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Search of human proteins with 21264337
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 3 [Homo sapiens]
(1544 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 3138 0.0
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 836 0.0
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 763 0.0
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 721 0.0
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 422 e-117
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 93 2e-18
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 93 2e-18
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 92 5e-18
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 90 2e-17
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 90 2e-17
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 89 3e-17
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 89 3e-17
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 89 3e-17
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 88 7e-17
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 88 7e-17
gi|23510413 sorting nexin 26 [Homo sapiens] 88 7e-17
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 87 1e-16
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 87 2e-16
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 87 2e-16
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 86 3e-16
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 85 5e-16
gi|187608516 centaurin, beta 2 [Homo sapiens] 85 5e-16
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 85 5e-16
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 85 5e-16
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 85 6e-16
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 84 1e-15
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 84 1e-15
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 83 2e-15
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 83 2e-15
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 83 2e-15
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
[Homo sapiens]
Length = 1544
Score = 3138 bits (8137), Expect = 0.0
Identities = 1544/1544 (100%), Positives = 1544/1544 (100%)
Query: 1 MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILR 60
MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILR
Sbjct: 1 MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILR 60
Query: 61 LLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPAL 120
LLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPAL
Sbjct: 61 LLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPAL 120
Query: 121 GGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSS 180
GGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSS
Sbjct: 121 GGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSS 180
Query: 181 QISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLE 240
QISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLE
Sbjct: 181 QISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLE 240
Query: 241 AREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQ 300
AREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQ
Sbjct: 241 AREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQ 300
Query: 301 GNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFR 360
GNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFR
Sbjct: 301 GNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFR 360
Query: 361 TESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELA 420
TESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELA
Sbjct: 361 TESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELA 420
Query: 421 LYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQE 480
LYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQE
Sbjct: 421 LYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQE 480
Query: 481 AVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISK 540
AVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISK
Sbjct: 481 AVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISK 540
Query: 541 VQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRL 600
VQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRL
Sbjct: 541 VQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRL 600
Query: 601 GLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGL 660
GLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGL
Sbjct: 601 GLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGL 660
Query: 661 LPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFAS 720
LPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFAS
Sbjct: 661 LPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFAS 720
Query: 721 ENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTS 780
ENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTS
Sbjct: 721 ENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTS 780
Query: 781 AVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGP 840
AVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGP
Sbjct: 781 AVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGP 840
Query: 841 GPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGG 900
GPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGG
Sbjct: 841 GPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGG 900
Query: 901 AAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRD 960
AAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRD
Sbjct: 901 AAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRD 960
Query: 961 ARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVI 1020
ARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVI
Sbjct: 961 ARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVI 1020
Query: 1021 GCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQEL 1080
GCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQEL
Sbjct: 1021 GCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQEL 1080
Query: 1081 IDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSP 1140
IDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSP
Sbjct: 1081 IDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSP 1140
Query: 1141 TLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCS 1200
TLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCS
Sbjct: 1141 TLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCS 1200
Query: 1201 ASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLK 1260
ASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLK
Sbjct: 1201 ASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLK 1260
Query: 1261 EKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSI 1320
EKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSI
Sbjct: 1261 EKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSI 1320
Query: 1321 LKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLS 1380
LKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLS
Sbjct: 1321 LKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLS 1380
Query: 1381 MFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLT 1440
MFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLT
Sbjct: 1381 MFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLT 1440
Query: 1441 SQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETT 1500
SQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETT
Sbjct: 1441 SQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETT 1500
Query: 1501 AGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT 1544
AGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT
Sbjct: 1501 AGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT 1544
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
[Homo sapiens]
Length = 1704
Score = 836 bits (2159), Expect = 0.0
Identities = 482/1179 (40%), Positives = 686/1179 (58%), Gaps = 64/1179 (5%)
Query: 260 SPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMY 319
S ++ S ISPYA F + + + SGWLDKLSPQG +FQ+R+V+F+G S+ Y
Sbjct: 457 SGNADSSAVSSQAISPYACFYGASAK--KVKSGWLDKLSPQGKRMFQKRWVKFDGLSISY 514
Query: 320 FGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLK 379
+ ++K+ + KG+IPL+AI R DNKF+V+T QR FVFR E E +R+ W S L + LK
Sbjct: 515 YNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALK 574
Query: 380 EQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIEL 439
Q L + P + G LELRG+KAK+F LS + L K+EQ F G+GI I +
Sbjct: 575 SQSLTSQSQAVVTPE--KCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPM 632
Query: 440 QGCSVRE---TKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIW 496
+V++ T +SF+++TP+R FSFTAE+ +Q W A+Q+++ ETLSDYEVAEKIW
Sbjct: 633 NVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIW 692
Query: 497 SNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIV 556
N +NR CADC + PDWA++NL VVICK+CAGQHR+LG SKV+SLK+D S+WSNE++
Sbjct: 693 FNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELI 752
Query: 557 QLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQL 616
+LFIV+GN RAN FWAG L E LH D+ R FI++KY+ G FRK +L
Sbjct: 753 ELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEEL 812
Query: 617 LQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPA-PDGSCPGLLPSDP---------- 665
+ALCAAV +P++L+ M L F G + P S P LL
Sbjct: 813 NKALCAAVVKPDVLETMALL-----FSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLY 867
Query: 666 -------------SPGVYNEVVVRATY-SGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVL 711
S GV ++ ++T+ FLY +P S + S ++ + + WCVL
Sbjct: 868 HNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAP-SAASKLSSEKKLLEETNKKWCVL 926
Query: 712 -GAALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTD 770
G L + ++ S P I +++CL + F FE+ L R+ FG +
Sbjct: 927 EGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAE 986
Query: 771 GADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGD 830
+ + WT A+ K F PL L +G+L+ + A W G+ +
Sbjct: 987 TSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKD----CHALDQWRKGWFAMDKS 1042
Query: 831 HLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLD 890
L C D +HLRRLQE+++ + +K + L+LVE GRTLY+ G +LD
Sbjct: 1043 SLHFCLQM---QEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLD 1099
Query: 891 FTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARS 950
FT W+ AI AAG G LQ+QQ+S+ D+PIIV++CI+FVTQ+GL + +Y+K G
Sbjct: 1100 FTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHI 1159
Query: 951 LRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKN 1010
LL F++DARS KLR G+H +EDVT LK F ++DD + + L P W A +
Sbjct: 1160 SELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDK 1219
Query: 1011 QRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRG 1070
+R++KY I LP VNR TLA +I HLYRVQKC+ +N M NLAL+F+ +FQT G+
Sbjct: 1220 ERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQT 1279
Query: 1071 EHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLP 1130
EV V+++LI+ Y+ +F++ DQV Q+D+E S IT WKD Q+SQAGDL++EVY+E++ P
Sbjct: 1280 SEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEP 1339
Query: 1131 DNCVTLKVSPTLTAEELTNQVLEMRGTAAGM-DLWVTFEIREHGELERPLHPKEKVLEQA 1189
D + +++SP + AEELTN +L ++ D+W TFE+ E+ ELERPLH KE VLEQ
Sbjct: 1340 DCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQV 1399
Query: 1190 LQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPR-------VGLLRCREEPPRLL-G 1241
L+W L EP SA L++K+ A I+ S R G+L+ +EEP ++L G
Sbjct: 1400 LRWSSLAEPGSAYLVVKRFLTADT------IKHCSDRSTLGSIKEGILKIKEEPSKILSG 1453
Query: 1242 SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKM 1301
++FQ+R+F+LR L L K+ KSSK ++ + L K Y G++KK+KPPT WG T EK
Sbjct: 1454 NKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKH 1513
Query: 1302 HLYLSCTDEDEMWDWTTSILKAQHD-DQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSG 1360
H +L C +W TSI AQH+ D P + S K G +PL+PI+ +
Sbjct: 1514 HWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQ-HEGN 1572
Query: 1361 ATLLSAN-QTLRRLHNRRTLSMFFPMKSSQGSVEEQEEL 1398
ATL N ++ R R LS +S S++E+ +
Sbjct: 1573 ATLARKNIESARAELERLRLSEKCDKESVDSSLKERASM 1611
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/58 (39%), Positives = 35/58 (60%)
Query: 6 DLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILRLLQ 63
++DI +L +++LEQY F G T + L+++GIS TGHR+RIL+ LQ
Sbjct: 8 NVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQ 65
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
isoform c [Homo sapiens]
Length = 1450
Score = 763 bits (1971), Expect = 0.0
Identities = 510/1468 (34%), Positives = 733/1468 (49%), Gaps = 161/1468 (10%)
Query: 7 LDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILR-LLQTG 65
L +A WL +HLEQY F +HGL A +GL L +G+ GHR+RIL LL+
Sbjct: 9 LSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRILAGLLRAH 68
Query: 66 TEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRP--------GL- 116
T SP+PAP+ P +PVP R +F PAT P GL
Sbjct: 69 T---------------SPAPAPRPTP-RPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLP 112
Query: 117 ------------------SPALGGPGVSRSPEPSPRP------PPLPTSSSEQSSALNTV 152
+P+ P P P+ R PP+P + ++
Sbjct: 113 AAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLP 172
Query: 153 EMMPNSIYFGLDSRGRAQAAQD-----KAPDSSQISAPTPALRPTTGTVHIMDPGCLYYG 207
S+ L S + Q+ + + P P P P + Y
Sbjct: 173 TKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYD 232
Query: 208 VQPVGTPGAPDR--------------RESRGVCQGRAEHRLSRQDLEAREDAGYASLELP 253
P PGAP R R R LS D E+ +A +P
Sbjct: 233 EVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVP 292
Query: 254 GDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLL-SGWLDKLSPQGNYVFQRRFVQF 312
S + ++ P + +TP++ +GWLDK PQG+Y++Q+R+V+
Sbjct: 293 NGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRL 352
Query: 313 NGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCS 372
+ L YF S+KD + K I + I + D KF+VIT R F FR ES+ +R W
Sbjct: 353 DTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQ 412
Query: 373 TLQSCLKEQR---------LLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYK 423
LQ + EQR LLG P QP R G LELRG K K++ A+ ++ LYK
Sbjct: 413 ALQQAMAEQRARARLSSAYLLGVPGSEQPDR---AGSLELRGFKNKLYVAVVGDKVQLYK 469
Query: 424 SEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVT 483
+ + + LGIGI FI++ +V+E RSFDL TP+R FSF+A+S ++ W A+Q A+
Sbjct: 470 NLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIA 529
Query: 484 ETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQS 543
E LS EVAE+IW+ NR CADCG+ +PDWA++NL VVICK+CAG+HR LG+G+SKV+S
Sbjct: 530 EALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRS 589
Query: 544 LKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLF 603
LK+D VW+ +++LF+ LGN NRFWA +PP E L P ++P R + KYR G +
Sbjct: 590 LKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKY 649
Query: 604 RKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAP------- 653
R+ HP + + +L +ALCAAV +L + L C + F G+ P AP
Sbjct: 650 RRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAE 705
Query: 654 ---------------DGSCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPR 698
P L P Y+ V+ ++SGFLY + + K R
Sbjct: 706 QAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDR 763
Query: 699 RGRDAPPRLWCVLG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFEL 757
R R+ R WCVLG L F +E + P I+ +IVCL V PP T F +FE+
Sbjct: 764 RAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDT---HGFEHTFEV 820
Query: 758 ILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAP 817
G R+ FG + A+ W + K F P LL RLGRL ++ A
Sbjct: 821 YTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQ 880
Query: 818 GLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVET 877
W S L G L GP E+ + LR+LQE+S+ ++ + LVLVE
Sbjct: 881 EGWFS----LSGSELRAVFPEGP----CEEPLQLRKLQELSIQGDSE----NQVLVLVER 928
Query: 878 GRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRL 937
RTLY+QGE RLDF W AI AA G L EQQ+ DIP+IV C+ ++TQ GL
Sbjct: 929 RRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTS 988
Query: 938 EGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLL 997
EG+YRK G +++ RLL R+DARSV L+ GE V+DV+ LKRF R+L D + +
Sbjct: 989 EGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQR 1048
Query: 998 PRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLAL 1057
W EA+E+ + +++ +Y++++ LP VNR T+ LI HLY VQ + NQM NLA+
Sbjct: 1049 LTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAI 1108
Query: 1058 LFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS--- 1114
+F P++FQTDG+ RV+++LI+ Y+ VF +D +++ + E++ I + +
Sbjct: 1109 VFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGT 1168
Query: 1115 -QAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREH 1172
AGD I VY+E++ + +KV ++TAEELT ++L+ R D W FE+ E
Sbjct: 1169 QHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNER 1228
Query: 1173 GELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRC 1232
E ERPLH EKVL + L++KK +A L+ R + G+++
Sbjct: 1229 EEAERPLHFAEKVLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKF 1283
Query: 1233 REEPPRLLG-----SRFQERFFLLRGRCLLLLKEKKSS-----------KPEREWPLEGA 1276
RE+ LLG F +R+F+L CL L KE +S +PE+EWP++
Sbjct: 1284 RED-RSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSL 1342
Query: 1277 KVYLGIRKKLKPPTPWGFTLI-----LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPV 1331
KVYLG++KKL+PPT WGFT++ EK YL C + E+ +W + L QHD
Sbjct: 1343 KVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWP 1402
Query: 1332 VLRRHSSSDLARQKFGTMPLLPIRGDDS 1359
S + + G++ L+P+RG ++
Sbjct: 1403 SEPSRVSRAVPEVRLGSVSLIPLRGSEN 1430
Score = 35.4 bits (80), Expect = 0.43
Identities = 39/134 (29%), Positives = 50/134 (37%), Gaps = 37/134 (27%)
Query: 1426 STTREWTVKPENPLTSQKSLDQP--FLSKSSTLGQEERPPEP----------PPGPPSKS 1473
+TT + + P+ ++S P F + S+ PP P PP PP
Sbjct: 104 TTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTG 163
Query: 1474 SPQARGSL----EEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSP-TGLPTQTPGFP 1528
P+ SL EE LL LSS P PQS P + LP P P
Sbjct: 164 PPRLLVSLPTKEEESLLPSLSS-----------------PPQPQSEEPLSTLPQGPPQPP 206
Query: 1529 TQPPCTSSPPSSQP 1542
+ PPC PP P
Sbjct: 207 SPPPC---PPEIPP 217
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform a [Homo sapiens]
Length = 1205
Score = 721 bits (1860), Expect = 0.0
Identities = 433/1136 (38%), Positives = 624/1136 (54%), Gaps = 92/1136 (8%)
Query: 286 LTPLL-SGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSK 344
+TP++ +GWLDK PQG+Y++Q+R+V+ + L YF S+KD + K I + I +
Sbjct: 80 VTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIG 139
Query: 345 DNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQR---------LLGHPRPPQPPRP 395
D KF+VIT R F FR ES+ +R W LQ + EQR LLG P QP R
Sbjct: 140 DQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDR- 198
Query: 396 LRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL 455
G LELRG K K++ A+ ++ LYK+ + + LGIGI FI++ +V+E RSFDL
Sbjct: 199 --AGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLT 256
Query: 456 TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWA 515
TP+R FSF+A+S ++ W A+Q A+ E LS EVAE+IW+ NR CADCG+ +PDWA
Sbjct: 257 TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWA 316
Query: 516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTL 575
++NL VVICK+CAG+HR LG+G+SKV+SLK+D VW+ +++LF+ LGN NRFWA +
Sbjct: 317 SINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANV 376
Query: 576 PPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQ 635
PP E L P ++P R + KYR G +R+ HP + + +L +ALCAAV +L +
Sbjct: 377 PPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQAL 436
Query: 636 LLC---VEAFEGEEPWFPPAP----------------------DGSCPGLLPSDPSPGVY 670
L C + F G+ P AP P L P Y
Sbjct: 437 LGCGAGINCFSGD----PEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHY 492
Query: 671 NEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLG-AALEMFASENSPEPLSL 729
+ V+ ++SGFLY + + K RR R+ R WCVLG L F +E + P
Sbjct: 493 SVVLPTVSHSGFLYKTASAGKL--LQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGE 550
Query: 730 IQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPL 789
I+ +IVCL V PP T F +FE+ G R+ FG + A+ W + K F P
Sbjct: 551 IRASEIVCLAVPPPDT---HGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPP 607
Query: 790 SCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMV 849
LL RLGRL ++ A W S L G L GP E+ +
Sbjct: 608 LAEDLLARDFERLGRLPYKAGLSLQRAQEGWFS----LSGSELRAVFPEGP----CEEPL 659
Query: 850 HLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGL 909
LR+LQE+S+ ++ + LVLVE RTLY+QGE RLDF W AI AA G L
Sbjct: 660 QLRKLQELSIQGDSE----NQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL 715
Query: 910 QEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPG 969
EQQ+ DIP+IV C+ ++TQ GL EG+YRK G +++ RLL R+DARSV L+ G
Sbjct: 716 SEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEG 775
Query: 970 EHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRR 1029
E V+DV+ LKRF R+L D + + W EA+E+ + +++ +Y++++ LP VNR
Sbjct: 776 EQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 835
Query: 1030 TLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFD 1089
T+ LI HLY VQ + NQM NLA++F P++FQTDG+ RV+++LI+ Y+ VF
Sbjct: 836 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFS 895
Query: 1090 IDSDQVAQIDLEVSLITTWKDVQLS----QAGDLIMEVYIEQQLPDNCVTLKVSPTLTAE 1145
+D +++ + E++ I + + AGD I VY+E++ + +KV ++TAE
Sbjct: 896 VDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAE 955
Query: 1146 ELTNQVLEMRGTA-AGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLL 1204
ELT ++L+ R D W FE+ E E ERPLH EKVL + L+
Sbjct: 956 ELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLP-----ILHGLGTDSHLV 1010
Query: 1205 LKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLG-----SRFQERFFLLRGRCLLLL 1259
+KK +A L+ R + G+++ RE+ LLG F +R+F+L CL L
Sbjct: 1011 VKKHQAMEAMLLYLASRVGDTKHGMMKFRED-RSLLGLGLPSGGFHDRYFILNSSCLRLY 1069
Query: 1260 KEKKSS-----------KPEREWPLEGAKVYLGIRKKLKPPTPWGFTLI-----LEKMHL 1303
KE +S +PE+EWP++ KVYLG++KKL+PPT WGFT++ EK
Sbjct: 1070 KEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQW 1129
Query: 1304 YLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDS 1359
YL C + E+ +W + L QHD S + + G++ L+P+RG ++
Sbjct: 1130 YLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSEN 1185
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform d [Homo sapiens]
Length = 1133
Score = 422 bits (1086), Expect = e-117
Identities = 278/785 (35%), Positives = 406/785 (51%), Gaps = 68/785 (8%)
Query: 616 LLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAPDG----------------- 655
L++ALCAAV +L + L C + F G+ P AP
Sbjct: 356 LIEALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAEQAGQTLQMEFLR 411
Query: 656 -----SCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCV 710
P L P Y+ V+ ++SGFLY + + K RR R+ R WCV
Sbjct: 412 NNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDRRAREEFSRRWCV 469
Query: 711 LG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGT 769
LG L F +E + P I+ +IVCL V PP T F +FE+ G R+ FG
Sbjct: 470 LGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHG---FEHTFEVYTEGERLYLFGL 526
Query: 770 DGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRG 829
+ A+ W + K F P LL RLGRL ++ A W S L G
Sbjct: 527 ESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFS----LSG 582
Query: 830 DHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRL 889
L GP E+ + LR+LQE+S+ ++ + LVLVE RTLY+QGE RL
Sbjct: 583 SELRAVFPEGPC----EEPLQLRKLQELSIQGDSEN----QVLVLVERRRTLYIQGERRL 634
Query: 890 DFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARAR 949
DF W AI AA G L EQQ+ DIP+IV C+ ++TQ GL EG+YRK G ++
Sbjct: 635 DFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSK 694
Query: 950 SLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQK 1009
+ RLL R+DARSV L+ GE V+DV+ LKRF R+L D + + W EA+E+ +
Sbjct: 695 TQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDE 754
Query: 1010 NQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069
+++ +Y++++ LP VNR T+ LI HLY VQ + NQM NLA++F P++FQTDG+
Sbjct: 755 EEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQ 814
Query: 1070 GEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS----QAGDLIMEVYI 1125
RV+++LI+ Y+ VF +D +++ + E++ I + + AGD I VY+
Sbjct: 815 DYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYL 874
Query: 1126 EQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREHGELERPLHPKEK 1184
E++ + +KV ++TAEELT ++L+ R D W FE+ E E ERPLH EK
Sbjct: 875 EEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEK 934
Query: 1185 VLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLG--- 1241
VL + L++KK +A L+ R + G+++ RE+ LLG
Sbjct: 935 VLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFRED-RSLLGLGL 988
Query: 1242 --SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLI-- 1297
F +R+F+L CL L KE +S +PE+EWP++ KVYLG++KKL+PPT WGFT++
Sbjct: 989 PSGGFHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHE 1048
Query: 1298 ---LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPI 1354
EK YL C + E+ +W + L QHD S + + G++ L+P+
Sbjct: 1049 TEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPL 1108
Query: 1355 RGDDS 1359
RG ++
Sbjct: 1109 RGSEN 1113
Score = 261 bits (666), Expect = 5e-69
Identities = 131/282 (46%), Positives = 185/282 (65%), Gaps = 13/282 (4%)
Query: 286 LTPLL-SGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSK 344
+TP++ +GWLDK PQG+Y++Q+R+V+ + L YF S+KD + K I + I +
Sbjct: 80 VTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIG 139
Query: 345 DNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQR---------LLGHPRPPQPPRP 395
D KF+VIT R F FR ES+ +R W LQ + EQR LLG P QP R
Sbjct: 140 DQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDR- 198
Query: 396 LRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL 455
G LELRG K K++ A+ ++ LYK+ + + LGIGI FI++ +V+E RSFDL
Sbjct: 199 --AGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLT 256
Query: 456 TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWA 515
TP+R FSF+A+S ++ W A+Q A+ E LS EVAE+IW+ NR CADCG+ +PDWA
Sbjct: 257 TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWA 316
Query: 516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQ 557
++NL VVICK+CAG+HR LG+G+SKV+SLK+D VW+ +++
Sbjct: 317 SINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 92.8 bits (229), Expect = 2e-18
Identities = 79/257 (30%), Positives = 113/257 (43%), Gaps = 52/257 (20%)
Query: 437 IELQGCSVRET--KSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAE- 493
+ L C VR + + FDL+T +R + F AE ++W + LQ + E LS + E
Sbjct: 337 LTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEP 396
Query: 494 -------------------------KIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCA 528
++ S N QC DCG++ P W + NLGV+ C QC+
Sbjct: 397 SAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCS 456
Query: 529 GQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATP- 587
G HR LG S++QSL LD + +E++ L + +GN N LP G P A
Sbjct: 457 GVHRELGVRFSRMQSLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESD 514
Query: 588 -GPRGEFISRKYRLGLFRK---PHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAF- 642
G R ++I KY F + P PQ +L A+C N L +EAF
Sbjct: 515 MGTRRDYIMAKYVEHRFARRCTPEPQ-----RLWTAIC----------NRDLLSVLEAFA 559
Query: 643 EGEEPWFP-PAPDGSCP 658
G++ P P PD P
Sbjct: 560 NGQDFGQPLPGPDAQAP 576
Score = 37.7 bits (86), Expect = 0.087
Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 1459 EERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPT 1518
E+ PP P S++ Q E+SSL ET LGSP+ SS SP
Sbjct: 740 EDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSPLEP 799
Query: 1519 GLPTQTPGFP----TQPPCTSSP 1537
G P+Q P +PP TS P
Sbjct: 800 GDPSQAPPNSEEGLREPPGTSRP 822
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 92.8 bits (229), Expect = 2e-18
Identities = 79/257 (30%), Positives = 113/257 (43%), Gaps = 52/257 (20%)
Query: 437 IELQGCSVRET--KSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAE- 493
+ L C VR + + FDL+T +R + F AE ++W + LQ + E LS + E
Sbjct: 346 LTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEP 405
Query: 494 -------------------------KIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCA 528
++ S N QC DCG++ P W + NLGV+ C QC+
Sbjct: 406 SAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCS 465
Query: 529 GQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATP- 587
G HR LG S++QSL LD + +E++ L + +GN N LP G P A
Sbjct: 466 GVHRELGVRFSRMQSLTLDL-LGPSELL-LALNMGNTSFNEVMEAQLPSHGGPKPSAESD 523
Query: 588 -GPRGEFISRKYRLGLFRK---PHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAF- 642
G R ++I KY F + P PQ +L A+C N L +EAF
Sbjct: 524 MGTRRDYIMAKYVEHRFARRCTPEPQ-----RLWTAIC----------NRDLLSVLEAFA 568
Query: 643 EGEEPWFP-PAPDGSCP 658
G++ P P PD P
Sbjct: 569 NGQDFGQPLPGPDAQAP 585
Score = 37.7 bits (86), Expect = 0.087
Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 1459 EERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPT 1518
E+ PP P S++ Q E+SSL ET LGSP+ SS SP
Sbjct: 749 EDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSPLEP 808
Query: 1519 GLPTQTPGFP----TQPPCTSSP 1537
G P+Q P +PP TS P
Sbjct: 809 GDPSQAPPNSEEGLREPPGTSRP 831
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 91.7 bits (226), Expect = 5e-18
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 22/198 (11%)
Query: 443 SVRETKSRSFDLLTPH---RCFSFTAESGGARQSWAAALQEAVTETLSDYEVA------- 492
S E SF+ + + + F A + R+ W ++Q + +L A
Sbjct: 598 SATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLG 657
Query: 493 --------EKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSL 544
+ + + R N C DC + PDWA++NLG ++C +C+G HR LG+ +S+V+SL
Sbjct: 658 NQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSL 717
Query: 545 KLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFR 604
LD W E++ + +GN AN W G L PDA + +I KY LF
Sbjct: 718 DLDD--WPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFL 775
Query: 605 KPHP--QYPDHSQLLQAL 620
P P P QLL+A+
Sbjct: 776 APLPSSDVPLGQQLLRAV 793
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 89.7 bits (221), Expect = 2e-17
Identities = 54/182 (29%), Positives = 87/182 (47%), Gaps = 20/182 (10%)
Query: 443 SVRETKSRSFDLL---TPHRCFSFTAESGGARQSWAAALQEAV---------------TE 484
S + + +F+ L + + + F A S R +W A++ + T+
Sbjct: 511 SAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTD 570
Query: 485 TLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSL 544
+ S+ + I + + N C DCG+ P WA++NLG +IC +C+G HR LG+ +S+V+SL
Sbjct: 571 SQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSL 630
Query: 545 KLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFR 604
LD W E+ + +GND ANR W D++ R +I KY LF
Sbjct: 631 DLDD--WPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFL 688
Query: 605 KP 606
P
Sbjct: 689 AP 690
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 89.7 bits (221), Expect = 2e-17
Identities = 51/161 (31%), Positives = 81/161 (50%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C DC
Sbjct: 287 FKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDC 346
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+LG+ +S+V+SL+LD W E+ ++ +GND A
Sbjct: 347 ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 404
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ ++T + +I KY LF P P
Sbjct: 405 NSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLP 445
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 89.4 bits (220), Expect = 3e-17
Identities = 51/161 (31%), Positives = 80/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C DC
Sbjct: 400 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDC 459
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+LG+ +S+V+SL+LD W E+ ++ +GND A
Sbjct: 460 ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 517
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 89.0 bits (219), Expect = 3e-17
Identities = 51/159 (32%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 463 FTAESGGARQSWAAALQEAV---------------TETLSDYEVAEKIWSNRANRQCADC 507
F A S R +W A++ + T++ S+ + I + + N C DC
Sbjct: 890 FEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDC 949
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
G+ P WA++NLG +IC +C+G HR LG+ +S+V+SL LD W E+ + +GND A
Sbjct: 950 GAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIGNDTA 1007
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKP 606
NR W D++ R +I KY LF P
Sbjct: 1008 NRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAP 1046
Score = 33.9 bits (76), Expect = 1.3
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 19/89 (21%)
Query: 54 HRKRILRLLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQR 113
HR+ L + + G +P P+ SPAP A P +PV PA +R
Sbjct: 71 HRQDALWISTSSAGTGGAEP-------PALSPAP-ASPARPV-----------SPAPGRR 111
Query: 114 PGLSPALGGPGVSRSPEPSPRPPPLPTSS 142
L GP +S P P+P PTSS
Sbjct: 112 LSLWAVPPGPPLSGGLSPDPKPGGAPTSS 140
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 89.0 bits (219), Expect = 3e-17
Identities = 51/161 (31%), Positives = 80/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C DC
Sbjct: 400 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDC 459
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+LG+ +S+V+SL+LD W E+ ++ +GND A
Sbjct: 460 ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 517
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 518 NSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLP 558
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 87.8 bits (216), Expect = 7e-17
Identities = 54/168 (32%), Positives = 86/168 (51%), Gaps = 4/168 (2%)
Query: 899 GGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFR 958
G G G + + +PI+++ + V HGL EG+YRK GA R+ L +
Sbjct: 1692 GVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQ 1751
Query: 959 RDARSVKLRPGEHF-VEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYK 1017
D +VKL E+F + +T LK++ REL +P+ + + A ELP+K ++L
Sbjct: 1752 TDPAAVKL---ENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIY 1808
Query: 1018 DVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQ 1065
V+ LP N +L LI HL +V +N+M LA++FAP + +
Sbjct: 1809 AVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLR 1856
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 87.8 bits (216), Expect = 7e-17
Identities = 54/168 (32%), Positives = 86/168 (51%), Gaps = 4/168 (2%)
Query: 899 GGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFR 958
G G G + + +PI+++ + V HGL EG+YRK GA R+ L +
Sbjct: 1692 GVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQ 1751
Query: 959 RDARSVKLRPGEHF-VEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYK 1017
D +VKL E+F + +T LK++ REL +P+ + + A ELP+K ++L
Sbjct: 1752 TDPAAVKL---ENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIY 1808
Query: 1018 DVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQ 1065
V+ LP N +L LI HL +V +N+M LA++FAP + +
Sbjct: 1809 AVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLR 1856
Score = 34.3 bits (77), Expect = 0.96
Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 6/65 (9%)
Query: 1478 RGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSP 1537
RGS EE L E S+ E AG G+ P +P P P G PT P+ P ++P
Sbjct: 1990 RGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCP-GAPT-----PSPLPTVAAP 2043
Query: 1538 PSSQP 1542
P +P
Sbjct: 2044 PRRRP 2048
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 87.8 bits (216), Expect = 7e-17
Identities = 55/165 (33%), Positives = 93/165 (56%), Gaps = 7/165 (4%)
Query: 906 GTGLQEQQMSRG-DIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSV 964
G L E + G D+P ++ C F+ HG+ ++G+YR G + RL EF D+ +
Sbjct: 314 GCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEF--DSERI 370
Query: 965 KLRPGEHFVED---VTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIG 1021
G F++D V+ K +FREL +P+ + +L ++ EA +P + +RL + DVI
Sbjct: 371 PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQ 430
Query: 1022 CLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQT 1066
LP + RTL L+ HL R+ + +A M RNLA+++AP++ ++
Sbjct: 431 QLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRS 475
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 87.4 bits (215), Expect = 1e-16
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C DC
Sbjct: 400 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDC 459
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G H +LG+ +S+V+SL+LD W E+ ++ +GND A
Sbjct: 460 ETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 517
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 86.7 bits (213), Expect = 2e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 906 GTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVK 965
G LQ+ + IP+ V+ C+ F+ GL EG+YR G + + +F +D ++
Sbjct: 1261 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1319
Query: 966 LRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPR 1025
L E V V LK FF +L DP+ L P EAA++P K +RL K+++
Sbjct: 1320 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1379
Query: 1026 VNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTD 1067
VN +I HL RV + +N M NL++ F P++ + D
Sbjct: 1380 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1421
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 86.7 bits (213), Expect = 2e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 906 GTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVK 965
G LQ+ + IP+ V+ C+ F+ GL EG+YR G + + +F +D ++
Sbjct: 1260 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1318
Query: 966 LRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPR 1025
L E V V LK FF +L DP+ L P EAA++P K +RL K+++
Sbjct: 1319 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1378
Query: 1026 VNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTD 1067
VN +I HL RV + +N M NL++ F P++ + D
Sbjct: 1379 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1420
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 85.9 bits (211), Expect = 3e-16
Identities = 60/214 (28%), Positives = 97/214 (45%), Gaps = 42/214 (19%)
Query: 438 ELQGCSVRETKSRS----FDLLTPHRCFSFTAESGGARQSWAAALQEAV----------- 482
+L+ CSV+ + F++L+P + A+S RQ+W A+Q ++
Sbjct: 314 DLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSC 373
Query: 483 -------------------TET----LSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNL 519
T+T + V +++ S N QC DCG P WA++NL
Sbjct: 374 YSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINL 433
Query: 520 GVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGE 579
GV++C +C+G HR+LG SKV+SL LD+ W E+++L LGN N+ +
Sbjct: 434 GVLLCIECSGIHRSLGVHCSKVRSLTLDS--WEPELLKLMCELGNSAVNQIYEAQCEGAG 491
Query: 580 GLHPDATPGPRGE--FISRKYRLGLFRKPHPQYP 611
P A+ + + +I KY F + P P
Sbjct: 492 SRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAP 525
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 85.1 bits (209), Expect = 5e-16
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C DC
Sbjct: 423 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDC 482
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+LG +S+V+SL+LD W E+ ++ + ND A
Sbjct: 483 ETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDD--WPVELRKVMSSIVNDLA 540
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 85.1 bits (209), Expect = 5e-16
Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 44/203 (21%)
Query: 438 ELQGCSVRETKSRS----FDLLTPHRCFSFTAESGGARQSWAAALQEAVTETL------- 486
+L+ C+V+ + F++++P + A+S RQ+W A+Q ++
Sbjct: 312 DLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDES 371
Query: 487 ---------------SDYEVAEKIWSNRA----------NRQCADCGSSRPDWAAVNLGV 521
S E EK+ + N C DCG + P WA++NLG+
Sbjct: 372 EKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGI 431
Query: 522 VICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFW------AGTL 575
+C +C+G HR+LG SKV+SL LDT W E+++L LGND NR + G
Sbjct: 432 TLCIECSGIHRSLGVHFSKVRSLTLDT--WEPELLKLMCELGNDVINRVYEANVEKMGIK 489
Query: 576 PPGEGLHPDATPGPRGEFISRKY 598
P G + R +++ RK+
Sbjct: 490 KPQPGQRQEKEAYIRAKYVERKF 512
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 85.1 bits (209), Expect = 5e-16
Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A++ + +L E + + I + R N C DC
Sbjct: 515 FEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDC 574
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P+WA++NLG ++C +C+G HR LG+ +S+V+SL LD W E++++ +GN+ A
Sbjct: 575 ETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDD--WPVELIKVMSSIGNELA 632
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W + D+T + +I KY LF P P
Sbjct: 633 NSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLP 673
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 85.1 bits (209), Expect = 5e-16
Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A++ + +L E + + I + R N C DC
Sbjct: 568 FEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDC 627
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P+WA++NLG ++C +C+G HR LG+ +S+V+SL LD W E++++ +GN+ A
Sbjct: 628 ETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDD--WPVELIKVMSSIGNELA 685
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W + D+T + +I KY LF P P
Sbjct: 686 NSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLP 726
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 84.7 bits (208), Expect = 6e-16
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETLSDYEVA---------------EKIWSNRANRQCADC 507
F A + R +W A+Q + +L E + + I + R N C D
Sbjct: 423 FEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDY 482
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+LG+ +S+V+SL+LD W E+ ++ +GND A
Sbjct: 483 ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDD--WPVELRKVMSSIGNDLA 540
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLP 581
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 84.0 bits (206), Expect = 1e-15
Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETL---------------SDYEVAEKIWSNRANRQCADC 507
F A + R +W A+Q + +L S+ + I + R N C DC
Sbjct: 423 FEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDC 482
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+ G+ +S+V+SL+LD W E+ ++ +GN+ A
Sbjct: 483 ETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDD--WPVELRKVMSSIGNELA 540
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLP 581
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 84.0 bits (206), Expect = 1e-15
Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 463 FTAESGGARQSWAAALQEAVTETL---------------SDYEVAEKIWSNRANRQCADC 507
F A + R +W A+Q + +L S+ + I + R N C DC
Sbjct: 423 FEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDC 482
Query: 508 GSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRA 567
+ P WA++NLGV++C +C+G HR+ G+ +S+V+SL+LD W E+ ++ +GN+ A
Sbjct: 483 ETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDD--WPVELRKVMSSIGNELA 540
Query: 568 NRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608
N W G+ +T + +I KY LF P P
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLP 581
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sapiens]
Length = 731
Score = 82.8 bits (203), Expect = 2e-15
Identities = 65/209 (31%), Positives = 102/209 (48%), Gaps = 26/209 (12%)
Query: 906 GTGLQEQQMSRGD-IPIIVDACISFVTQHGLRLEGVYRKGG--ARARSLRLLAEFRR--- 959
G L+ GD +P + CI+ V + GL ++G+YR G A + LR L + R
Sbjct: 522 GCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVT 581
Query: 960 -DARSV-KLRPGEHFVED-----------VTDTLKRFFRELDDPVTSARLLPRWREAAEL 1006
D R V +PG+ D VT LK F REL P+ LLP +R A L
Sbjct: 582 SDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALAL 641
Query: 1007 PQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVF-- 1064
+ Q L + +++IG +P+ N TL L+ HL RV + N+M NL ++F P++F
Sbjct: 642 SESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRP 701
Query: 1065 --QTDGRGEHEV---RVLQELIDGYISVF 1088
+T H + +++Q ++ + S+F
Sbjct: 702 EQETSDPAAHALYPGQLVQLMLTNFTSLF 730
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sapiens]
Length = 547
Score = 82.8 bits (203), Expect = 2e-15
Identities = 65/209 (31%), Positives = 102/209 (48%), Gaps = 26/209 (12%)
Query: 906 GTGLQEQQMSRGD-IPIIVDACISFVTQHGLRLEGVYRKGG--ARARSLRLLAEFRR--- 959
G L+ GD +P + CI+ V + GL ++G+YR G A + LR L + R
Sbjct: 338 GCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVT 397
Query: 960 -DARSV-KLRPGEHFVED-----------VTDTLKRFFRELDDPVTSARLLPRWREAAEL 1006
D R V +PG+ D VT LK F REL P+ LLP +R A L
Sbjct: 398 SDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALAL 457
Query: 1007 PQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVF-- 1064
+ Q L + +++IG +P+ N TL L+ HL RV + N+M NL ++F P++F
Sbjct: 458 SESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRP 517
Query: 1065 --QTDGRGEHEV---RVLQELIDGYISVF 1088
+T H + +++Q ++ + S+F
Sbjct: 518 EQETSDPAAHALYPGQLVQLMLTNFTSLF 546
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sapiens]
Length = 890
Score = 82.8 bits (203), Expect = 2e-15
Identities = 54/164 (32%), Positives = 91/164 (55%), Gaps = 5/164 (3%)
Query: 906 GTGLQEQ-QMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSV 964
G LQE Q S ++P ++ +C FV ++G+ ++G+YR G + +L EF + R
Sbjct: 19 GCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESE-RKP 76
Query: 965 KLRPGEHF--VEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGC 1022
LR + + V+ K +FREL DP+ + RL ++ EA + + +RL K +V+
Sbjct: 77 DLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRE 136
Query: 1023 LPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQT 1066
LP N RTL L+ HL + +A M RNLA+++AP++ ++
Sbjct: 137 LPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,440,001
Number of Sequences: 37866
Number of extensions: 4307415
Number of successful extensions: 42467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 267
Number of HSP's successfully gapped in prelim test: 990
Number of HSP's that attempted gapping in prelim test: 27577
Number of HSP's gapped (non-prelim): 12770
length of query: 1544
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1429
effective length of database: 13,892,928
effective search space: 19852994112
effective search space used: 19852994112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.