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Search of human proteins with 212549736
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|212549736 anaphase-promoting complex subunit 7 isoform a
[Homo sapiens]
(599 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 1178 0.0
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 1049 0.0
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 68 2e-11
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 68 2e-11
gi|83415184 transmembrane and tetratricopeptide repeat containin... 63 9e-10
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 54 3e-07
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 54 3e-07
gi|118402596 cell division cycle protein 23 [Homo sapiens] 46 1e-04
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 45 2e-04
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 45 2e-04
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 45 2e-04
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 43 7e-04
gi|224809432 transmembrane and tetratricopeptide repeat containi... 43 0.001
gi|118766328 transmembrane and tetratricopeptide repeat containi... 40 0.008
gi|118766330 transmembrane and tetratricopeptide repeat containi... 40 0.008
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens] 37 0.052
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 37 0.068
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 36 0.088
gi|215422388 death-domain associated protein isoform a [Homo sap... 36 0.088
gi|215422366 death-domain associated protein isoform b [Homo sap... 36 0.088
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear... 36 0.088
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear... 36 0.088
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 36 0.12
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 36 0.12
gi|254281232 zinc finger and SCAN domain containing 12 [Homo sap... 35 0.15
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 35 0.20
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 35 0.20
gi|27881484 zinc finger CCCH-type containing 7B [Homo sapiens] 35 0.20
gi|70980549 programmed cell death 11 [Homo sapiens] 35 0.26
gi|93277096 limbin [Homo sapiens] 35 0.26
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 1178 bits (3047), Expect = 0.0
Identities = 599/599 (100%), Positives = 599/599 (100%)
Query: 1 MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL 60
MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL
Sbjct: 1 MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL 60
Query: 61 LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST 120
LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST
Sbjct: 61 LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST 120
Query: 121 GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK 180
GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK
Sbjct: 121 GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK 180
Query: 181 KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI 240
KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI
Sbjct: 181 KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI 240
Query: 241 KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML 300
KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML
Sbjct: 241 KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML 300
Query: 301 DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY 360
DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY
Sbjct: 301 DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY 360
Query: 361 LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS 420
LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS
Sbjct: 361 LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS 420
Query: 421 NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV 480
NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV
Sbjct: 421 NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV 480
Query: 481 KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP 540
KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP
Sbjct: 481 KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP 540
Query: 541 NDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ 599
NDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ
Sbjct: 541 NDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ 599
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 1049 bits (2713), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL 60
MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL
Sbjct: 1 MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL 60
Query: 61 LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST 120
LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST
Sbjct: 61 LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST 120
Query: 121 GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK 180
GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK
Sbjct: 121 GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK 180
Query: 181 KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI 240
KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI
Sbjct: 181 KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI 240
Query: 241 KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML 300
KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML
Sbjct: 241 KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML 300
Query: 301 DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY 360
DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY
Sbjct: 301 DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY 360
Query: 361 LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS 420
LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS
Sbjct: 361 LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS 420
Query: 421 NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV 480
NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV
Sbjct: 421 NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV 480
Query: 481 KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIAL 536
KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIAL
Sbjct: 481 KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIAL 536
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 68.2 bits (165), Expect = 2e-11
Identities = 67/318 (21%), Positives = 129/318 (40%), Gaps = 8/318 (2%)
Query: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLF 332
+L + YF + + F + + ++ Y ++GM++Y L + + L L
Sbjct: 507 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 566
Query: 333 NISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEA 392
++ E W +G + + A+ +AIQ++ N A L G + +A
Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 626
Query: 393 IIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCL 452
+ FR AIR+ P + + GL Y A + + K L N Q+ LL + +
Sbjct: 627 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM---HFQKALDINPQSSVLLCHIGV 683
Query: 453 EDPVTQ--EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRN-ALANQSDC 509
+ EKA L+KA+ P +A +L +KY+ + L +
Sbjct: 684 VQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKES 743
Query: 510 VLHRILGDFLVAVNEYQEAMDQYSIALSLDPN--DQKSLEGMQKMEKEESPTDATQEEDV 567
+++ ++G + + A+ +S A+ LDP + + E + K + TQEE +
Sbjct: 744 LVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 803
Query: 568 DDMEGSGEEGDLEGSDSE 585
+ S E + D++
Sbjct: 804 MGTDESQESSMTDADDTQ 821
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 68.2 bits (165), Expect = 2e-11
Identities = 67/318 (21%), Positives = 129/318 (40%), Gaps = 8/318 (2%)
Query: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLF 332
+L + YF + + F + + ++ Y ++GM++Y L + + L L
Sbjct: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
Query: 333 NISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEA 392
++ E W +G + + A+ +AIQ++ N A L G + +A
Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620
Query: 393 IIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCL 452
+ FR AIR+ P + + GL Y A + + K L N Q+ LL + +
Sbjct: 621 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM---HFQKALDINPQSSVLLCHIGV 677
Query: 453 EDPVTQ--EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRN-ALANQSDC 509
+ EKA L+KA+ P +A +L +KY+ + L +
Sbjct: 678 VQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKES 737
Query: 510 VLHRILGDFLVAVNEYQEAMDQYSIALSLDPN--DQKSLEGMQKMEKEESPTDATQEEDV 567
+++ ++G + + A+ +S A+ LDP + + E + K + TQEE +
Sbjct: 738 LVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797
Query: 568 DDMEGSGEEGDLEGSDSE 585
+ S E + D++
Sbjct: 798 MGTDESQESSMTDADDTQ 815
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 62.8 bits (151), Expect = 9e-10
Identities = 93/433 (21%), Positives = 160/433 (36%), Gaps = 54/433 (12%)
Query: 161 GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVA 220
G+ + K++ AN K G+ + ++ Y+ L+ P A+ L +L+ AE
Sbjct: 367 GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAK 426
Query: 221 SMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSL----EKK----SLLRDNVD 272
+Q P ++RA+ + +L EKK +LL+D++
Sbjct: 427 MYYQRALQLHPQ------------------HNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
Query: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGM-------DVYGYLLAREGRLEDVE 325
AD Y +F++A+ + IK + YG L G E
Sbjct: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
Query: 326 NLGCRLFNISDQHAEPWVVSGC-------HSFYSKRYSRALYLGAKAIQLNSNSVQALLL 378
+ +S H V G +S + Y RAL + KA + L
Sbjct: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA--------EILSP 580
Query: 379 KGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLG 438
GA N GR +EA+ ++EA L P + + L + +EA M N++
Sbjct: 581 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEET 640
Query: 439 ANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVK----KAELLSREQKYED 494
+ LL+ + + +KA +DKAL +P K + + K L + +
Sbjct: 641 GCLECYRLLSAIYSKQE-NHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDK 699
Query: 495 GIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKME 553
R A+ N +G +Y A Y AL L P+ + E + K++
Sbjct: 700 AFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLD 759
Query: 554 KEESPTDATQEED 566
+ E +E+D
Sbjct: 760 RLEKRLQEVREKD 772
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 54.3 bits (129), Expect = 3e-07
Identities = 79/375 (21%), Positives = 135/375 (36%), Gaps = 16/375 (4%)
Query: 175 LANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMT---MNVIQTVP 231
L N+YK+ GQ + ++ Y+ LR P +D + L + V ++ ++ +Q P
Sbjct: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
Query: 232 NL----DWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDN 287
+L L +KA + + C L+ + +L ++ G+
Sbjct: 145 DLYCVRSDLGNLLKALGRLEE-------AKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 197
Query: 288 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGC 347
++ FE+A LDP + G +L + R ++S HA C
Sbjct: 198 WLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLAC 257
Query: 348 HSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRL 407
+ A+ +AI+L + A AL+ G V EA + A+RL P
Sbjct: 258 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 317
Query: 408 DCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDK 467
D L +I EA+ + + A + LA+V + QE A +
Sbjct: 318 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQE-ALMHYKE 376
Query: 468 ALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQ 526
A+ P + A L Q + + A+ N + H L
Sbjct: 377 AIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIP 436
Query: 527 EAMDQYSIALSLDPN 541
EA+ Y AL L P+
Sbjct: 437 EAIASYRTALKLKPD 451
Score = 47.4 bits (111), Expect = 4e-05
Identities = 56/209 (26%), Positives = 88/209 (42%), Gaps = 21/209 (10%)
Query: 343 VVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRL 402
++S H F +R R+ + AI+ N +A G + G++QEAI H+R A+RL
Sbjct: 50 LLSSIH-FQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL 108
Query: 403 APCRLDCYEGLIECYLASNSIR---EAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQE 459
P +D Y L +A+ + +A V A L L L L+ E
Sbjct: 109 KPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNL----LKALGRLE 164
Query: 460 KAKTLLDKALTQRPDYIKA-------VVKKAELLSREQKYEDGIALLRNALANQSDCVLH 512
+AK KA+ +P++ A + E+ +E + L N L D ++
Sbjct: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFL----DAYIN 220
Query: 513 RILGDFLVAVNEYQEAMDQYSIALSLDPN 541
LG+ L + A+ Y ALSL PN
Sbjct: 221 --LGNVLKEARIFDRAVAAYLRALSLSPN 247
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/147 (23%), Positives = 62/147 (42%)
Query: 270 NVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGC 329
+ D L +LA++ G+ + +V + +A + P +L ++G+L++
Sbjct: 316 HADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYK 375
Query: 330 RLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRV 389
IS A+ + G + AL +AIQ+N A + ++ G +
Sbjct: 376 EAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI 435
Query: 390 QEAIIHFREAIRLAPCRLDCYEGLIEC 416
EAI +R A++L P D Y L C
Sbjct: 436 PEAIASYRTALKLKPDFPDAYCNLAHC 462
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 54.3 bits (129), Expect = 3e-07
Identities = 79/375 (21%), Positives = 135/375 (36%), Gaps = 16/375 (4%)
Query: 175 LANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMT---MNVIQTVP 231
L N+YK+ GQ + ++ Y+ LR P +D + L + V ++ ++ +Q P
Sbjct: 95 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 154
Query: 232 NL----DWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDN 287
+L L +KA + + C L+ + +L ++ G+
Sbjct: 155 DLYCVRSDLGNLLKALGRLEE-------AKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 207
Query: 288 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGC 347
++ FE+A LDP + G +L + R ++S HA C
Sbjct: 208 WLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLAC 267
Query: 348 HSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRL 407
+ A+ +AI+L + A AL+ G V EA + A+RL P
Sbjct: 268 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 327
Query: 408 DCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDK 467
D L +I EA+ + + A + LA+V + QE A +
Sbjct: 328 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQE-ALMHYKE 386
Query: 468 ALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQ 526
A+ P + A L Q + + A+ N + H L
Sbjct: 387 AIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIP 446
Query: 527 EAMDQYSIALSLDPN 541
EA+ Y AL L P+
Sbjct: 447 EAIASYRTALKLKPD 461
Score = 47.4 bits (111), Expect = 4e-05
Identities = 56/209 (26%), Positives = 88/209 (42%), Gaps = 21/209 (10%)
Query: 343 VVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRL 402
++S H F +R R+ + AI+ N +A G + G++QEAI H+R A+RL
Sbjct: 60 LLSSIH-FQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL 118
Query: 403 APCRLDCYEGLIECYLASNSIR---EAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQE 459
P +D Y L +A+ + +A V A L L L L+ E
Sbjct: 119 KPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNL----LKALGRLE 174
Query: 460 KAKTLLDKALTQRPDYIKA-------VVKKAELLSREQKYEDGIALLRNALANQSDCVLH 512
+AK KA+ +P++ A + E+ +E + L N L D ++
Sbjct: 175 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFL----DAYIN 230
Query: 513 RILGDFLVAVNEYQEAMDQYSIALSLDPN 541
LG+ L + A+ Y ALSL PN
Sbjct: 231 --LGNVLKEARIFDRAVAAYLRALSLSPN 257
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/147 (23%), Positives = 62/147 (42%)
Query: 270 NVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGC 329
+ D L +LA++ G+ + +V + +A + P +L ++G+L++
Sbjct: 326 HADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYK 385
Query: 330 RLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRV 389
IS A+ + G + AL +AIQ+N A + ++ G +
Sbjct: 386 EAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI 445
Query: 390 QEAIIHFREAIRLAPCRLDCYEGLIEC 416
EAI +R A++L P D Y L C
Sbjct: 446 PEAIASYRTALKLKPDFPDAYCNLAHC 472
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/201 (23%), Positives = 79/201 (39%), Gaps = 10/201 (4%)
Query: 225 NVIQTVPNLDWLSV---WIKAYAFVHTGDNSRAISTICSLEKKSLLRD-----NVDLLGS 276
N+I L +LS+ W+K + H + I +L+K L D + ++
Sbjct: 211 NLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEE--ALQKYQNLIDVGFSKSSYIVSQ 268
Query: 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISD 336
+A Y D ++ F + + DPY I+ MD + LL ++ L L I
Sbjct: 269 IAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDK 328
Query: 337 QHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHF 396
E V G + ++ +A +A++LN + A L G M AI +
Sbjct: 329 YRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAY 388
Query: 397 REAIRLAPCRLDCYEGLIECY 417
R AI + + GL + Y
Sbjct: 389 RHAIEVNKRDYRAWYGLGQTY 409
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/171 (23%), Positives = 77/171 (45%), Gaps = 16/171 (9%)
Query: 313 YLLAREGRLED----VENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAK---- 364
Y + REG +E +ENLG L + Q+A+ + +S+ R+ + K
Sbjct: 255 YYVCREGDIEKASTKLENLGNTLDAMEPQNAQ--LFYNITLAFSRTCGRSQLILQKIQTL 312
Query: 365 ---AIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASN 421
A LN + G + GRV+EA+ ++ A+ L + G I+C L
Sbjct: 313 LERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEG 372
Query: 422 SIREA---MVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKAL 469
+++A + N + +++G +A+ + L A + ++ QE+ LL+ L
Sbjct: 373 QLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVL 423
Score = 34.3 bits (77), Expect = 0.34
Identities = 34/143 (23%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 406 RLDCYEGLIECYLASNSIREAM-VMANNVYKTLGANAQTLTLLATVCLEDPVTQ-EKAKT 463
RL + LI+ + + EA V+ + +++ G + + +A L E+A +
Sbjct: 616 RLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALS 675
Query: 464 LLDKALTQRPDYIKAVVKKAELLSREQK----YEDGIALLRNALANQSDCVLHRILGDFL 519
+L ++P +I+A K A++ + +K Y + +AN +L LGD
Sbjct: 676 ILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLL---LGDAY 732
Query: 520 VAVNEYQEAMDQYSIALSLDPND 542
+ + E +EA+ Y AL+ +P D
Sbjct: 733 MNILEPEEAIVAYEQALNQNPKD 755
Score = 32.7 bits (73), Expect = 0.98
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 133 PSEIEVKYKMAECYTMLKQDKDA-IAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTS 191
P IE + KMA+ Y ++DK I I R P+ ++L + Y + ++ +
Sbjct: 685 PYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVA 744
Query: 192 YKEVLRQCP 200
Y++ L Q P
Sbjct: 745 YEQALNQNP 753
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 10/168 (5%)
Query: 386 MGRVQEAIIHFREAIRLAP-----CRLDCYEGLIECYLASNS--IREAMVMANNVYKTLG 438
+ +V+EA+ F E IRL P C+ + Y +NS I+ AM V K
Sbjct: 414 LDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFP 473
Query: 439 ANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAEL-LSREQKYEDGIA 497
A+ L A L D KA + DK + PD V K L L +Q + G+
Sbjct: 474 RCAEGYALYAQ-ALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLE 532
Query: 498 LLRNALANQSDC-VLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQK 544
L+ A+ + C + +G V ++A+D ++ A++L ++ +
Sbjct: 533 LISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEME 580
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 44.7 bits (104), Expect = 2e-04
Identities = 52/211 (24%), Positives = 99/211 (46%), Gaps = 21/211 (9%)
Query: 242 AYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLAD---LYFRAG--DNKNSVLK-FE 295
AY + +G AI ++L++ DL+ ++ Y + G D KN+ L FE
Sbjct: 150 AYVLIGSGLYDEAIRHF-----STMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFE 204
Query: 296 QAQM--LDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSK 353
+++ L+P + + +L+ GR+ + N + + A + G F S+
Sbjct: 205 LSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISE 263
Query: 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGL 413
Y+ A ++++LN N A+L KG + G ++EAI F+EA++ +D Y+ L
Sbjct: 264 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 323
Query: 414 IECY-------LASNSIREAMVMANNVYKTL 437
+ Y A+ S ++A+++ N +TL
Sbjct: 324 GQAYRELGNFEAATESFQKALLLNQNHVQTL 354
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/114 (29%), Positives = 49/114 (42%), Gaps = 27/114 (23%)
Query: 364 KAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSI 423
KA+ LN N VQ L L+G L + G +QEA+ +F+ ++L P C ++A
Sbjct: 342 KALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQF 401
Query: 424 REAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIK 477
E G AQT V L DP+ +KA P+Y+K
Sbjct: 402 YE------------GIKAQT-----KVMLNDPLPGQKAS----------PEYLK 428
Score = 34.7 bits (78), Expect = 0.26
Identities = 42/198 (21%), Positives = 81/198 (40%), Gaps = 15/198 (7%)
Query: 353 KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP-CRLDCYE 411
K AL+ ++ I L + + + L +GR+ EA+ +AI+L P RL +
Sbjct: 196 KNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHR 255
Query: 412 GLI-----ECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLD 466
G + + A ++++ + N + + + LT L++ + K
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKN--QPIAMLYKGLTFFHRGLLKEAIESFK------ 307
Query: 467 KALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEY 525
+AL Q+ D+I A + +E + AL NQ+ ++ G L
Sbjct: 308 EALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSL 367
Query: 526 QEAMDQYSIALSLDPNDQ 543
QEA+ + L L+P ++
Sbjct: 368 QEALKNFKRCLQLEPYNE 385
Score = 33.1 bits (74), Expect = 0.75
Identities = 23/90 (25%), Positives = 39/90 (43%)
Query: 452 LEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVL 511
L D E A L + +T PD + ++AE+LS + + + L A+ Q L
Sbjct: 192 LHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARL 251
Query: 512 HRILGDFLVAVNEYQEAMDQYSIALSLDPN 541
+R G +Y A + + +L L+ N
Sbjct: 252 YRHRGTLYFISEDYATAHEDFQQSLELNKN 281
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 43.1 bits (100), Expect = 7e-04
Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 7/95 (7%)
Query: 350 FYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDC 409
F S+ Y+ A ++++LN N A+L KG + G ++EAI F+EA++ +D
Sbjct: 207 FISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDA 266
Query: 410 YEGLIECY-------LASNSIREAMVMANNVYKTL 437
Y+ L + Y A+ S ++A+++ N +TL
Sbjct: 267 YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTL 301
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/114 (29%), Positives = 49/114 (42%), Gaps = 27/114 (23%)
Query: 364 KAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSI 423
KA+ LN N VQ L L+G L + G +QEA+ +F+ ++L P C ++A
Sbjct: 289 KALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQF 348
Query: 424 REAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIK 477
E G AQT V L DP+ +KA P+Y+K
Sbjct: 349 YE------------GIKAQT-----KVMLNDPLPGQKAS----------PEYLK 375
Score = 31.2 bits (69), Expect = 2.8
Identities = 37/168 (22%), Positives = 70/168 (41%), Gaps = 15/168 (8%)
Query: 383 LRNMGRVQEAIIHFREAIRLAP-CRLDCYEGLI-----ECYLASNSIREAMVMANNVYKT 436
L +GR+ EA+ +AI+L P RL + G + + A ++++ + N +
Sbjct: 173 LSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKN--QP 230
Query: 437 LGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGI 496
+ + LT L++ + K +AL Q+ D+I A + +E
Sbjct: 231 IAMLYKGLTFFHRGLLKEAIESFK------EALKQKVDFIDAYKSLGQAYRELGNFEAAT 284
Query: 497 ALLRNA-LANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQ 543
+ A L NQ+ ++ G L QEA+ + L L+P ++
Sbjct: 285 ESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNE 332
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/197 (20%), Positives = 87/197 (44%), Gaps = 15/197 (7%)
Query: 365 AIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGL----------- 413
A+++N N+ + G AL N + A+ +F +A + P + + +
Sbjct: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
Query: 414 --IECYLASNSIREAMVMANNVYKTLGANAQTLTL-LATVCLEDPVTQEKAKTLLDKALT 470
E Y+ + S+ ++ + N + + LA + + E+A L +A++
Sbjct: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAIS 557
Query: 471 QRPDYIKAVVKKAELLSREQK-YEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAM 529
RPD+ +A + + ELL + K + A L+ ++++ L L + + E EA+
Sbjct: 558 MRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEAL 617
Query: 530 DQYSIALSLDPNDQKSL 546
++ AL L+P + +L
Sbjct: 618 KNFNRALELNPKHKLAL 634
Score = 33.9 bits (76), Expect = 0.44
Identities = 40/201 (19%), Positives = 75/201 (37%), Gaps = 4/201 (1%)
Query: 294 FEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSK 353
+ QA + P + G LL + + + + + +A+ W K
Sbjct: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
Query: 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQ---EAIIHFREAIRLAPCRLDCY 410
+ AL +A++LN AL ++ G V+ EA I P + Y
Sbjct: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
Query: 411 EGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALT 470
L + EA + K L A+ ++ + + KA +L++ L
Sbjct: 672 FNLGMLAMDDKKDNEAEIWMKKAIK-LQADFRSALFNLALLYSQTAKELKALPILEELLR 730
Query: 471 QRPDYIKAVVKKAELLSREQK 491
PD+IK ++ K ++L ++K
Sbjct: 731 YYPDHIKGLILKGDILMNQKK 751
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 39.7 bits (91), Expect = 0.008
Identities = 61/289 (21%), Positives = 105/289 (36%), Gaps = 44/289 (15%)
Query: 253 RAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYG 312
R+ ++C L K + ++ +LAD G+ ++ + +A L+P + M+ G
Sbjct: 472 RSALSVCPLNAKV----HYNIGKNLAD----KGNQTAAIRYYREAVRLNPKYVHAMNNLG 523
Query: 313 YLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNS 372
+L L++ E L I A W+ G KR+ A AI+
Sbjct: 524 NILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKY 583
Query: 373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANN 432
G ++ R +A+ +R A L P E LA N++
Sbjct: 584 PDCYYNLGRLYADLNRHVDALNAWRNATVLKP----------EHSLAWNNM--------- 624
Query: 433 VYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKY 492
+ L++ +A+ + +AL P+ + A +L + QKY
Sbjct: 625 ----------------IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKY 668
Query: 493 EDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP 540
++ AL A+ AN + H L A Y I+L LDP
Sbjct: 669 KESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDP 717
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 39.7 bits (91), Expect = 0.008
Identities = 61/289 (21%), Positives = 105/289 (36%), Gaps = 44/289 (15%)
Query: 253 RAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYG 312
R+ ++C L K + ++ +LAD G+ ++ + +A L+P + M+ G
Sbjct: 491 RSALSVCPLNAKV----HYNIGKNLAD----KGNQTAAIRYYREAVRLNPKYVHAMNNLG 542
Query: 313 YLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNS 372
+L L++ E L I A W+ G KR+ A AI+
Sbjct: 543 NILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKY 602
Query: 373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANN 432
G ++ R +A+ +R A L P E LA N++
Sbjct: 603 PDCYYNLGRLYADLNRHVDALNAWRNATVLKP----------EHSLAWNNM--------- 643
Query: 433 VYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKY 492
+ L++ +A+ + +AL P+ + A +L + QKY
Sbjct: 644 ----------------IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKY 687
Query: 493 EDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP 540
++ AL A+ AN + H L A Y I+L LDP
Sbjct: 688 KESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDP 736
>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
Length = 858
Score = 37.0 bits (84), Expect = 0.052
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDC-VLHRILGD 517
E+AK L +ALT PD ++ + +LSR +LR+A+ QS C + LG+
Sbjct: 762 EEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGE 821
Query: 518 FLVAVNEYQEAMDQYSIALSLD 539
L A + + A+D + AL L+
Sbjct: 822 VLQAQGQNEAAVDCFLTALELE 843
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 36.6 bits (83), Expect = 0.068
Identities = 28/116 (24%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 448 ATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQS 507
A CL + ++A L Q P+ I A++ KA + ++ Y +A + AL
Sbjct: 135 ACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNP 194
Query: 508 DC--VLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDA 561
C + +G V +N+ ++A +S AL L+ +L G+ +E D+
Sbjct: 195 GCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADS 250
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 36.2 bits (82), Expect = 0.088
Identities = 17/56 (30%), Positives = 31/56 (55%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQ 594
D + E ++ E+EE TD+ +EED++ M+ E+ + E + EAA D ++
Sbjct: 439 DDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 494
Score = 30.4 bits (67), Expect = 4.9
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDME--GSGEEGDLEGSDSEAA 587
D D + + ++ E+EE +AT E+ +D+E G+E D E + E A
Sbjct: 436 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEA 486
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 36.2 bits (82), Expect = 0.088
Identities = 17/56 (30%), Positives = 31/56 (55%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQ 594
D + E ++ E+EE TD+ +EED++ M+ E+ + E + EAA D ++
Sbjct: 439 DDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 494
Score = 30.4 bits (67), Expect = 4.9
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDME--GSGEEGDLEGSDSEAA 587
D D + + ++ E+EE +AT E+ +D+E G+E D E + E A
Sbjct: 436 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEA 486
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 36.2 bits (82), Expect = 0.088
Identities = 17/56 (30%), Positives = 31/56 (55%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQ 594
D + E ++ E+EE TD+ +EED++ M+ E+ + E + EAA D ++
Sbjct: 451 DDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506
Score = 30.4 bits (67), Expect = 4.9
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 539 DPNDQKSLEGMQKMEKEESPTDATQEEDVDDME--GSGEEGDLEGSDSEAA 587
D D + + ++ E+EE +AT E+ +D+E G+E D E + E A
Sbjct: 448 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEA 498
>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 36.2 bits (82), Expect = 0.088
Identities = 24/94 (25%), Positives = 48/94 (51%), Gaps = 14/94 (14%)
Query: 519 LVAVNEYQEA----MDQYSIALSLDPNDQKSLEG---MQKMEKEESPTDATQEEDVDDME 571
++ +N+YQE+ + Q + + DP DQ++ + + ++KEE + E+D ++ +
Sbjct: 145 VINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENED 204
Query: 572 GSGEEGDLEGSDSEAAQWAD-------QEQWFGM 598
G EE D E + E + D +E+ FG+
Sbjct: 205 GEEEELDEEEDEDEDVEGDDDKDEVSEEEEEFGL 238
>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 36.2 bits (82), Expect = 0.088
Identities = 24/94 (25%), Positives = 48/94 (51%), Gaps = 14/94 (14%)
Query: 519 LVAVNEYQEA----MDQYSIALSLDPNDQKSLEG---MQKMEKEESPTDATQEEDVDDME 571
++ +N+YQE+ + Q + + DP DQ++ + + ++KEE + E+D ++ +
Sbjct: 145 VINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENED 204
Query: 572 GSGEEGDLEGSDSEAAQWAD-------QEQWFGM 598
G EE D E + E + D +E+ FG+
Sbjct: 205 GEEEELDEEEDEDEDVEGDDDKDEVSEEEEEFGL 238
>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
[Homo sapiens]
Length = 438
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/162 (20%), Positives = 68/162 (41%), Gaps = 23/162 (14%)
Query: 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGL 413
RY A + + ++++S + AL ++G L +++A+ F +A+R+AP D +
Sbjct: 135 RYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAP---DHEKAC 191
Query: 414 IECYLASNSIREAMVMANNVYK-------------TLGANAQTLTLLATVCLEDPVTQEK 460
I C A +++ N +K LG + + A + K
Sbjct: 192 IACRNA-KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSK 250
Query: 461 AKTLLD------KALTQRPDYIKAVVKKAELLSREQKYEDGI 496
+ L D A+ YIKA +++A+ ++YE+ +
Sbjct: 251 LRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAV 292
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/162 (20%), Positives = 68/162 (41%), Gaps = 23/162 (14%)
Query: 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGL 413
RY A + + ++++S + AL ++G L +++A+ F +A+R+AP D +
Sbjct: 191 RYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAP---DHEKAC 247
Query: 414 IECYLASNSIREAMVMANNVYK-------------TLGANAQTLTLLATVCLEDPVTQEK 460
I C A +++ N +K LG + + A + K
Sbjct: 248 IACRNA-KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSK 306
Query: 461 AKTLLD------KALTQRPDYIKAVVKKAELLSREQKYEDGI 496
+ L D A+ YIKA +++A+ ++YE+ +
Sbjct: 307 LRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAV 348
Score = 29.6 bits (65), Expect = 8.3
Identities = 49/226 (21%), Positives = 93/226 (41%), Gaps = 22/226 (9%)
Query: 337 QHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHF 396
+ AE + G + K Y+ A KAI + + + A L +GR +EA+
Sbjct: 26 REAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDA 85
Query: 397 REAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTL-----GANAQTLTLLATVC 451
++++RL + + +C+L S+ AM + + L A AQ A
Sbjct: 86 QQSVRLDDSFVRGHLREGKCHL---SLGNAMAACRSFQRALELDHKNAQAQQEFKNANAV 142
Query: 452 LEDPVTQE---------KAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNA 502
+E E K +D+AL P + + KAE L+ +Y + ++ +
Sbjct: 143 MEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDI 202
Query: 503 L---ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKS 545
L + +D + R G L + ++A+ + AL + P+ +K+
Sbjct: 203 LRMDSTNADALYVR--GLCLYYEDCIEKAVQFFVQALRMAPDHEKA 246
>gi|254281232 zinc finger and SCAN domain containing 12 [Homo
sapiens]
Length = 611
Score = 35.4 bits (80), Expect = 0.15
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 16/158 (10%)
Query: 434 YKTLGANAQTLTLLATVCLE--DPVTQEKAKTL----LDKALTQRPDYIKAVVKKAELLS 487
Y+ + L+ L +C + P T K + L L++ LT P+ ++A V++ S
Sbjct: 54 YQETSGPREALSRLRELCHQWLRPETHTKEQILELLVLEQFLTILPEELQAWVQEQHPES 113
Query: 488 REQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLE 547
E+ + + L + D G+ + QE Q ++ L + SL+
Sbjct: 114 GEE-----VVTVLEDLERELDEP-----GEQVSVHTGEQEMFLQETVRLRKEGEPSMSLQ 163
Query: 548 GMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSE 585
M+ K ESP +Q+E V D+E E G+L+ SE
Sbjct: 164 SMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEVSE 201
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
sapiens]
Length = 504
Score = 35.0 bits (79), Expect = 0.20
Identities = 54/243 (22%), Positives = 97/243 (39%), Gaps = 26/243 (10%)
Query: 179 YKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSV 238
+KK + PS KE Q + D + L S ++ T I + + + V
Sbjct: 128 FKKVLKSNPSENEEKEAQSQL-IKSDEMQRLRSQALNAFGSGDYTA-AIAFLDKILEVCV 185
Query: 239 W------IKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVL 292
W ++A F+ G+ +AIS + + K L DN + ++ LY++ GD++ S+
Sbjct: 186 WDAELRELRAECFIKEGEPRKAISDLKAASK--LKNDNTEAFYKISTLYYQLGDHELSLS 243
Query: 293 KFEQAQMLDPYLIKGMDVYGYL------------LAREGRLEDVENLGCRLFNISDQHAE 340
+ + LD + Y + L R+GR D + + AE
Sbjct: 244 EVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAE 303
Query: 341 PWVVSG---CHSF-YSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHF 396
V S CH F ++ A+ + ++ +Q+ ++V AL + A EAI +
Sbjct: 304 YTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDY 363
Query: 397 REA 399
A
Sbjct: 364 ETA 366
Score = 30.4 bits (67), Expect = 4.9
Identities = 46/274 (16%), Positives = 108/274 (39%), Gaps = 31/274 (11%)
Query: 312 GYLLAREGRLEDVEN-----LGCRLFNISDQHAEPWVVSG----------CHSFYSKRYS 356
G+LL ++G+L++ E+ L ++ A+ ++ ++F S Y+
Sbjct: 112 GHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYT 171
Query: 357 RALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIEC 416
A+ K +++ + L+ G ++AI + A +L + + +
Sbjct: 172 AAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTL 231
Query: 417 Y-------LASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQE----KAKTLL 465
Y L+ + +RE + + + + Q L + + + ++ A +
Sbjct: 232 YYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKY 291
Query: 466 DKALTQRPDYIKAVVKKAELL----SREQKYEDGIALLRNALANQSDCV-LHRILGDFLV 520
+ + P + V+ E + S+++K + I + L + D V + + +
Sbjct: 292 ESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYL 351
Query: 521 AVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEK 554
Y EA+ Y A + NDQ+ EG++K ++
Sbjct: 352 IEEMYDEAIQDYETAQEHNENDQQIREGLEKAQR 385
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 35.0 bits (79), Expect = 0.20
Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 10/121 (8%)
Query: 351 YSKR--YSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLD 408
Y+K+ Y +A G K + L + + K AAL + R +EA + E ++
Sbjct: 48 YAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQ 107
Query: 409 CYEGL--IECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLD 466
EGL +E LA M N+Y+ L ++ +T TLL+ DP +E + L +
Sbjct: 108 LKEGLQNMEARLAERKFMNPFNMP-NLYQKLESDPRTRTLLS-----DPTYRELIEQLRN 161
Query: 467 K 467
K
Sbjct: 162 K 162
>gi|27881484 zinc finger CCCH-type containing 7B [Homo sapiens]
Length = 977
Score = 35.0 bits (79), Expect = 0.20
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 9/95 (9%)
Query: 306 KGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVV--------SGCHSFYSKRYSR 357
+G D++ ++ ++ +E L + SDQ A P + + C+ F Y +
Sbjct: 42 EGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACY-FTMGLYEK 100
Query: 358 ALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEA 392
AL KA+ L+S S++AL K AL +GR +EA
Sbjct: 101 ALEDSEKALGLDSESIRALFRKARALNELGRHKEA 135
>gi|70980549 programmed cell death 11 [Homo sapiens]
Length = 1871
Score = 34.7 bits (78), Expect = 0.26
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Query: 237 SVWIKAYAFVHTGDNSRAISTICSLEKKSL-LRDNVDLLGSLADLYFRAGDNKNSVLKFE 295
+VWIK AF+ + A + + L +++VD++ A L F+ GD + + FE
Sbjct: 1726 AVWIKYGAFLLRRSQAAASHRVLQRALECLPSKEHVDVIAKFAQLEFQLGDAERAKAIFE 1785
Query: 296 QAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNIS 335
P VY + + G +DV ++ R+ ++S
Sbjct: 1786 NTLSTYPKRTDVWSVYIDMTIKHGSQKDVRDIFERVIHLS 1825
>gi|93277096 limbin [Homo sapiens]
Length = 1308
Score = 34.7 bits (78), Expect = 0.26
Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 23/162 (14%)
Query: 430 ANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLS-R 488
A+ V + L N Q + +L++ EDP + +A L+ A R D A+L + R
Sbjct: 351 ADGVNEDLSLNDQMIDILSS---EDPGSMLQALEELEIATLNRAD--------ADLEACR 399
Query: 489 EQKYEDGIALLRNALANQ---SDCVLHRILG----DFLVAVNEYQEAMDQYSIALSLDPN 541
Q +D IALL L + S V ++ FL+ NE QE D+ +AL+ + +
Sbjct: 400 TQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECD 459
Query: 542 DQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSD 583
LE +KME + EE + ++ +GE +E S+
Sbjct: 460 ----LETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSN 497
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,460,442
Number of Sequences: 37866
Number of extensions: 831125
Number of successful extensions: 4633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 4096
Number of HSP's gapped (non-prelim): 437
length of query: 599
length of database: 18,247,518
effective HSP length: 108
effective length of query: 491
effective length of database: 14,157,990
effective search space: 6951573090
effective search space used: 6951573090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.