Search of human proteins with 209969686

Search of human proteins with 209969686

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209969686 GRAM domain containing 1A isoform 2 [Homo sapiens]
         (713 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209969686 GRAM domain containing 1A isoform 2 [Homo sapiens]      1438   0.0  
gi|92110010 GRAM domain containing 1A isoform 1 [Homo sapiens]       1425   0.0  
gi|144227752 GRAM domain containing 1B [Homo sapiens]                 602   e-172
gi|187936935 GRAM domain containing 1C [Homo sapiens]                 439   e-123
gi|226443022 GRAM domain containing 3 isoform 4 [Homo sapiens]        105   1e-22
gi|226443028 GRAM domain containing 3 isoform 5 [Homo sapiens]        105   2e-22
gi|226443011 GRAM domain containing 3 isoform 1 [Homo sapiens]        105   2e-22
gi|226443007 GRAM domain containing 3 isoform 2 [Homo sapiens]        105   2e-22
gi|226443017 GRAM domain containing 3 isoform 3 [Homo sapiens]        100   4e-21
gi|60593095 GRAM domain containing 2 [Homo sapiens]                    92   2e-18
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho...    65   3e-10
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso...    62   2e-09
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso...    62   2e-09
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso...    59   2e-08
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso...    59   2e-08
gi|156231067 TBC1 domain family, member 8 [Homo sapiens]               48   3e-05
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    39   0.013
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ...    39   0.022
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ...    39   0.022
gi|46560555 transmembrane protein 132E [Homo sapiens]                  38   0.029
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa...    37   0.049
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa...    37   0.049
gi|151101459 SAPS domain family, member 1 [Homo sapiens]               37   0.049
gi|154146199 sal-like 3 [Homo sapiens]                                 37   0.064
gi|38201677 teashirt family zinc finger 1 [Homo sapiens]               37   0.064
gi|163310725 ER degradation enhancer, mannosidase alpha-like 3 [...    37   0.064
gi|223468617 family with sequence similarity 75, member C1 [Homo...    37   0.083
gi|29789008 Huntingtin interacting protein C isoform 2 [Homo sap...    36   0.11 
gi|72534686 Huntingtin interacting protein C isoform 1 [Homo sap...    36   0.11 
gi|56549117 dynamin 1 isoform 2 [Homo sapiens]                         36   0.14 

>gi|209969686 GRAM domain containing 1A isoform 2 [Homo sapiens]
          Length = 713

 Score = 1438 bits (3722), Expect = 0.0
 Identities = 713/713 (100%), Positives = 713/713 (100%)

Query: 1   MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST 60
           MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST
Sbjct: 1   MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST 60

Query: 61  QSLGSRNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLS 120
           QSLGSRNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLS
Sbjct: 61  QSLGSRNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLS 120

Query: 121 ENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRC 180
           ENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRC
Sbjct: 121 ENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRC 180

Query: 181 FLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGD 240
           FLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGD
Sbjct: 181 FLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGD 240

Query: 241 VIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASS 300
           VIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASS
Sbjct: 241 VIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASS 300

Query: 301 SQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLS 360
           SQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLS
Sbjct: 301 SQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLS 360

Query: 361 GRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTI 420
           GRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTI
Sbjct: 361 GRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTI 420

Query: 421 PISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARN 480
           PISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARN
Sbjct: 421 PISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARN 480

Query: 481 KARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARG 540
           KARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARG
Sbjct: 481 KARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARG 540

Query: 541 LLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSA 600
           LLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSA
Sbjct: 541 LLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSA 600

Query: 601 LVLISIVLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQK 660
           LVLISIVLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQK
Sbjct: 601 LVLISIVLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQK 660

Query: 661 QFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS 713
           QFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS
Sbjct: 661 QFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS 713


>gi|92110010 GRAM domain containing 1A isoform 1 [Homo sapiens]
          Length = 724

 Score = 1425 bits (3689), Expect = 0.0
 Identities = 713/724 (98%), Positives = 713/724 (98%), Gaps = 11/724 (1%)

Query: 1   MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST 60
           MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST
Sbjct: 1   MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST 60

Query: 61  QSLGSRNFIRNSK-------MLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL 113
           QSLGSRNFIRNSK       MLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL
Sbjct: 61  QSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL 120

Query: 114 QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS 173
           QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS
Sbjct: 121 QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS 180

Query: 174 FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG 233
           FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG
Sbjct: 181 FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG 240

Query: 234 TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD 293
           TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD
Sbjct: 241 TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD 300

Query: 294 SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA 353
           SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA
Sbjct: 301 SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA 360

Query: 354 ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR 413
           ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR
Sbjct: 361 ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR 420

Query: 414 RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC 473
           RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC
Sbjct: 421 RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC 480

Query: 474 ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE 533
           ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE
Sbjct: 481 ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE 540

Query: 534 GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP 593
           GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP
Sbjct: 541 GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP 600

Query: 594 GAGIPSALVLISIV----LIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA 649
           GAGIPSALVLISIV    LIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA
Sbjct: 601 GAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA 660

Query: 650 TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD 709
           TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD
Sbjct: 661 TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD 720

Query: 710 DSFS 713
           DSFS
Sbjct: 721 DSFS 724


>gi|144227752 GRAM domain containing 1B [Homo sapiens]
          Length = 738

 Score =  602 bits (1553), Expect = e-172
 Identities = 339/731 (46%), Positives = 460/731 (62%), Gaps = 49/731 (6%)

Query: 4   TTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPG-TMVEKGSDSSSEKGGVPGTP---- 58
           T  +S RSTP+ SP LRKR +      P P+ + G TMVEKGSD SS+K   P TP    
Sbjct: 9   TASNSNRSTPACSPILRKRSR-----SPTPQNQDGDTMVEKGSDHSSDKS--PSTPEQGV 61

Query: 59  --STQSLGSRNFIRNSK-------MLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQR 109
             S  S   R+  +NSK       +LSPTYKQRNEDFRKLF +LP+ ERLIVDYSCALQR
Sbjct: 62  QRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQR 121

Query: 110 EILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKH 169
           +ILLQGRLYLSENWICFYSNIFRWET ++++LK++  + KEKTA+LIPNAIQ+CT+SEKH
Sbjct: 122 DILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKH 181

Query: 170 FFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSP-LQ 228
           FFTSFGARDR ++++FRLWQNALLEK L P+ELWH VHQCYG+ELGLTS+DEDYV P   
Sbjct: 182 FFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDD 241

Query: 229 LNGLGTPKEVG-DVIALSDITSSGAADRSQEPSPVGSRRGHVTPNL-SRASSDADHGAEE 286
            N +G  +E+  +   ++D +S  + +   + SP   ++      L S  SS+A    + 
Sbjct: 242 FNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDG 301

Query: 287 DKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSST 346
              E+   + D S  + +    +    E  +   P     LD   +E++ T+ S+ SS T
Sbjct: 302 LPLEEEALEGDGSLEKEL--AIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSD-SSDT 358

Query: 347 GEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSG 406
            +E ++ A   DLSGR  +N VF+   ++L  +LF++SPF + F++Q +F+D+   PW  
Sbjct: 359 HDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKK 418

Query: 407 DSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYF 466
           +   +Q RV+ YTI ++NPL PK+A+V ETQT+++   ++   V+D+EVLT  +PY DYF
Sbjct: 419 EENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYF 478

Query: 467 YTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKA 526
           YT +RY +  +ARNK+RLRVS+E+RYRKQPW LVK+ IEKN WSG+EDYF HLE ELAK 
Sbjct: 479 YTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKT 538

Query: 527 EKLSLEE----GGKDARGLLSGLRRRKRPLSWRAHGDGPQ---------HPDPDPCARAG 573
           E   L E      K+     + +RRRKRP    AH   P           P  +      
Sbjct: 539 ESTYLAEMHRQSPKEKASKTTTVRRRKRP---HAHLRVPHLEEVMSPVTTPTDEDVGHRI 595

Query: 574 IHTSGSLSSRFSEPSVDQGPGAGIPSALVL-----ISIVLIILIALNVLLFYRLWSLERT 628
            H +GS  +R        G      S L+L     I   L++L+ LN++LFY+LW LE T
Sbjct: 596 KHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYT 655

Query: 629 AHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSL 688
             T  +W  L L + + PQ+ TEWA++L  Q+++H  E+ KWR+I+++SV LLD+MK SL
Sbjct: 656 TQTLTAWQGLRLQE-RLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSL 714

Query: 689 EKLHQGITVSD 699
             L  GI   D
Sbjct: 715 INLQNGIRSRD 725


>gi|187936935 GRAM domain containing 1C [Homo sapiens]
          Length = 662

 Score =  439 bits (1128), Expect = e-123
 Identities = 261/623 (41%), Positives = 370/623 (59%), Gaps = 42/623 (6%)

Query: 76  SPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWET 135
           S TYK RNE++R+ F+ LP+ ERLI DY+CALQR+ILLQGRLYLSENW+CFYSNIFRWET
Sbjct: 61  SSTYKDRNEEYRRQFTHLPDTERLIADYACALQRDILLQGRLYLSENWLCFYSNIFRWET 120

Query: 136 TISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEK 195
           TISI LK +T + KEKTA+LIPNAIQI TESEK FFTSFGARDR +L IFRLWQN LL+K
Sbjct: 121 TISIALKNITFMTKEKTARLIPNAIQIVTESEKFFFTSFGARDRSYLSIFRLWQNVLLDK 180

Query: 196 TLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADR 255
           +L+ +E W L+ Q YG+ELGL +E+ + +S L +  +  P+  G     S +  SG  D 
Sbjct: 181 SLTRQEFWQLLQQNYGTELGLNAEEMENLS-LSIEDV-QPRSPG----RSSLDDSGERDE 234

Query: 256 SQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKE--EQVDSQPDASSSQTVTPVAEPPST 313
               S         + ++SR S          K    + +SQ +  + +++ P  E   T
Sbjct: 235 KLSKS-----ISFTSESISRVSETESFDGNSSKGGLGKEESQNEKQTKKSLLPTLEKKLT 289

Query: 314 EPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGA 373
                        LDL  +E L  D S++S S  EE        DL GRL IN +FH+ A
Sbjct: 290 RVPSKS-------LDLNKNEYLSLDKSSTSDSVDEE---NVPEKDLHGRLFINRIFHISA 339

Query: 374 ERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASV 433
           +R+ ++LF+ S F+Q F       DV  +PW+ +    Q R +TYTI +++PL  K  + 
Sbjct: 340 DRMFELLFTSSRFMQKFASSRNIIDVVSTPWTAELGGDQLRTMTYTIVLNSPLTGKCTAA 399

Query: 434 VETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYR 493
            E QTL++   +A   +VDSEVLT  +PY DYFYT +RYCI+  ++ K RLRVS++++YR
Sbjct: 400 TEKQTLYKESREARFYLVDSEVLTHDVPYHDYFYTVNRYCIIRSSKQKCRLRVSTDLKYR 459

Query: 494 KQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKL---SLEEGGKDARGLLSGLRRRKR 550
           KQPW LVKSLIEKNSWS +EDYF  LE +L   E +   ++E+ GK     L+GLRRR+R
Sbjct: 460 KQPWGLVKSLIEKNSWSSLEDYFKQLESDLLIEESVLNQAIEDPGK-----LTGLRRRRR 514

Query: 551 PLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLII 610
             + R     P+          G+   G ++ +  E            + +V++SI +++
Sbjct: 515 TFN-RTAETVPKLSSQHSSGDVGLGAKGDITGKKKEMENYN------VTLIVVMSIFVLL 567

Query: 611 LIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKW 670
           L+ LNV LF +L  +E   H  +S++ L L + K    A++     A   Q +  + H+ 
Sbjct: 568 LVLLNVTLFLKLSKIE---HAAQSFYRLRLQEEKSLNLASDMVS-RAETIQKNKDQAHRL 623

Query: 671 RQILRASVELLDEMKFSLEKLHQ 693
           + +LR S+ +L+++K SL  L +
Sbjct: 624 KGVLRDSIVMLEQLKSSLIMLQK 646


>gi|226443022 GRAM domain containing 3 isoform 4 [Homo sapiens]
          Length = 440

 Score =  105 bits (263), Expect = 1e-22
 Identities = 64/179 (35%), Positives = 93/179 (51%), Gaps = 5/179 (2%)

Query: 6   PHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGS 65
           PH  R TP +         +  P+    + +       G+  +S+K        T+S   
Sbjct: 45  PHLWRRTPQTRRKSLAYAHIFSPNLCFIQDQESKSSFDGASLASDKNDC----KTESKND 100

Query: 66  RNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWIC 125
               R     S  YK  N  F KLF  +P  E L   ++CALQ+EIL QG+L++SENWIC
Sbjct: 101 PKTERKKSSSSSQYKA-NMHFHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWIC 159

Query: 126 FYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLI 184
           F+S +F  +T ISI    VT +KK KTA L+PNA+ I T ++++ F S  +RD  + L+
Sbjct: 160 FHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL 218


>gi|226443028 GRAM domain containing 3 isoform 5 [Homo sapiens]
          Length = 416

 Score =  105 bits (261), Expect = 2e-22
 Identities = 59/159 (37%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 28  PSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKMLSPTYKQ--RNED 85
           PS     P+   ++   S SS +   +    +     S+N  +  +  S +  Q   N  
Sbjct: 36  PSVEADSPDQKKIISLWSKSSFDGASLASDKNDCKTESKNDPKTERKKSSSSSQYKANMH 95

Query: 86  FRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVT 145
           F KLF  +P  E L   ++CALQ+EIL QG+L++SENWICF+S +F  +T ISI    VT
Sbjct: 96  FHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVT 155

Query: 146 CLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLI 184
            +KK KTA L+PNA+ I T ++++ F S  +RD  + L+
Sbjct: 156 LIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL 194


>gi|226443011 GRAM domain containing 3 isoform 1 [Homo sapiens]
          Length = 447

 Score =  105 bits (261), Expect = 2e-22
 Identities = 59/159 (37%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 28  PSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKMLSPTYKQ--RNED 85
           PS     P+   ++   S SS +   +    +     S+N  +  +  S +  Q   N  
Sbjct: 67  PSVEADSPDQKKIISLWSKSSFDGASLASDKNDCKTESKNDPKTERKKSSSSSQYKANMH 126

Query: 86  FRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVT 145
           F KLF  +P  E L   ++CALQ+EIL QG+L++SENWICF+S +F  +T ISI    VT
Sbjct: 127 FHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVT 186

Query: 146 CLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLI 184
            +KK KTA L+PNA+ I T ++++ F S  +RD  + L+
Sbjct: 187 LIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL 225


>gi|226443007 GRAM domain containing 3 isoform 2 [Homo sapiens]
          Length = 432

 Score =  105 bits (261), Expect = 2e-22
 Identities = 59/159 (37%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 28  PSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKMLSPTYKQ--RNED 85
           PS     P+   ++   S SS +   +    +     S+N  +  +  S +  Q   N  
Sbjct: 52  PSVEADSPDQKKIISLWSKSSFDGASLASDKNDCKTESKNDPKTERKKSSSSSQYKANMH 111

Query: 86  FRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVT 145
           F KLF  +P  E L   ++CALQ+EIL QG+L++SENWICF+S +F  +T ISI    VT
Sbjct: 112 FHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVT 171

Query: 146 CLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLI 184
            +KK KTA L+PNA+ I T ++++ F S  +RD  + L+
Sbjct: 172 LIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL 210


>gi|226443017 GRAM domain containing 3 isoform 3 [Homo sapiens]
          Length = 328

 Score =  100 bits (250), Expect = 4e-21
 Identities = 49/102 (48%), Positives = 69/102 (67%)

Query: 83  NEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLK 142
           N  F KLF  +P  E L   ++CALQ+EIL QG+L++SENWICF+S +F  +T ISI   
Sbjct: 5   NMHFHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAF 64

Query: 143 EVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLI 184
            VT +KK KTA L+PNA+ I T ++++ F S  +RD  + L+
Sbjct: 65  SVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLL 106


>gi|60593095 GRAM domain containing 2 [Homo sapiens]
          Length = 354

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 50/127 (39%), Positives = 79/127 (62%), Gaps = 3/127 (2%)

Query: 78  TYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTI 137
           T  + N+ + KLF  +P  E ++   SCALQR+ LLQGRLY+S NW+CF++++F  +  +
Sbjct: 66  TLNKYNQQYHKLFKDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKV 125

Query: 138 SIQLKEVTCLKKEKTAKLIPNAIQICTE-SEKHFFTSFGARDRCFLLIFRLWQN--ALLE 194
            I +  V  +KK K A+L+PN + I T  S+K+ F S  +RD  + L+ R+  +     +
Sbjct: 126 VIPVVSVQMIKKHKMARLLPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSK 185

Query: 195 KTLSPRE 201
           K+LS RE
Sbjct: 186 KSLSVRE 192


>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
           sapiens]
          Length = 1266

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 39/110 (35%), Positives = 66/110 (60%), Gaps = 3/110 (2%)

Query: 79  YKQRNEDFRKLFSKLPEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFRWETTI 137
           +K+    F +LF  +PE E+L+  YSC+  + ++  QG +YLS N +CFYS +   E  +
Sbjct: 141 FKEAIVKFHRLFG-MPEEEKLVNYYSCSYWKGKVPRQGWMYLSINHLCFYSFLMGREAKL 199

Query: 138 SIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRL 187
            I+  ++T L+K  T  L+P+ I++ T S +HFF+ F   +  F L+ +L
Sbjct: 200 VIRWVDITQLEKNATL-LLPDVIKVSTRSSEHFFSVFLNINETFKLMEQL 248



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/107 (28%), Positives = 61/107 (57%), Gaps = 6/107 (5%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQ---REILLQGRLYLSENWICFYSNIFRWETT 136
           + ++E +R LF +LP+ E+L     C L     ++ + G++++S N+ICF S       +
Sbjct: 289 RAKSERYRALF-RLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENL-CS 346

Query: 137 ISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLL 183
           + I L+EVT ++K  ++ ++P+ + I T +   F  +   +DR FL+
Sbjct: 347 LIIPLREVTIVEKADSSSVLPSPLSISTRNRMTFLFA-NLKDRDFLV 392


>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 632

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/109 (36%), Positives = 64/109 (58%), Gaps = 5/109 (4%)

Query: 86  FRKLFSKLPEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFRWETTISIQLKEV 144
           F K F  LPE E+L+  YSC+  +  +  QG LYLS N++ FYS +   E  + I   EV
Sbjct: 147 FEKCFG-LPEKEKLVTYYSCSYWKGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEV 205

Query: 145 TCLKKEKTAKLI-PNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNAL 192
           +  K EKT+ +I   +I +C++ E H+F+ F   ++ +LL+ +L   A+
Sbjct: 206 S--KLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQLANYAI 252



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 5/73 (6%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQ---REILLQGRLYLSENWICFYSNIFRWETT 136
           +  +E F   F +LP+ E L   + C L          G++ +SEN+ICF S     + +
Sbjct: 281 RAHSEQFNAFF-RLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGN-QCS 338

Query: 137 ISIQLKEVTCLKK 149
           + I L+EV  + K
Sbjct: 339 VIIPLREVLAIDK 351


>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1120

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 40/109 (36%), Positives = 64/109 (58%), Gaps = 5/109 (4%)

Query: 86  FRKLFSKLPEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFRWETTISIQLKEV 144
           F K F  LPE E+L+  YSC+  +  +  QG LYLS N++ FYS +   E  + I   EV
Sbjct: 147 FEKCFG-LPEKEKLVTYYSCSYWKGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEV 205

Query: 145 TCLKKEKTAKLI-PNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNAL 192
           +  K EKT+ +I   +I +C++ E H+F+ F   ++ +LL+ +L   A+
Sbjct: 206 S--KLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQLANYAI 252



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 5/73 (6%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQ---REILLQGRLYLSENWICFYSNIFRWETT 136
           +  +E F   F +LP+ E L   + C L          G++ +SEN+ICF S     + +
Sbjct: 281 RAHSEQFNAFF-RLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGN-QCS 338

Query: 137 ISIQLKEVTCLKK 149
           + I L+EV  + K
Sbjct: 339 VIIPLREVLAIDK 351


>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 1233

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 34/97 (35%), Positives = 57/97 (58%), Gaps = 3/97 (3%)

Query: 79  YKQRNEDFRKLFSKLPEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFRWETTI 137
           +K+     RK F  +PE E+L+  YSC+  +  +  QG LYL+ N +CFYS +   E ++
Sbjct: 137 FKEAELKMRKQFG-MPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSL 195

Query: 138 SIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSF 174
            +Q  ++T L+K  T  L P +I++ T  ++ FF+ F
Sbjct: 196 VVQWVDITRLEKNATL-LFPESIRVDTRDQELFFSMF 231



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 34/107 (31%), Positives = 61/107 (57%), Gaps = 6/107 (5%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQ---REILLQGRLYLSENWICFYSNIFRWETT 136
           + +NE +R  F +LP  ERL    SC L     ++ + G++++S N+ICF S        
Sbjct: 284 RAKNECYRATF-RLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASK-EEDACH 341

Query: 137 ISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLL 183
           + I L+EVT ++K  ++ ++P+ + I T+S+  F  +   +DR FL+
Sbjct: 342 LIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFA-NLKDRDFLV 387


>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1250

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 34/97 (35%), Positives = 57/97 (58%), Gaps = 3/97 (3%)

Query: 79  YKQRNEDFRKLFSKLPEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFRWETTI 137
           +K+     RK F  +PE E+L+  YSC+  +  +  QG LYL+ N +CFYS +   E ++
Sbjct: 137 FKEAELKMRKQFG-MPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSL 195

Query: 138 SIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSF 174
            +Q  ++T L+K  T  L P +I++ T  ++ FF+ F
Sbjct: 196 VVQWVDITRLEKNATL-LFPESIRVDTRDQELFFSMF 231



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 34/107 (31%), Positives = 61/107 (57%), Gaps = 6/107 (5%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQ---REILLQGRLYLSENWICFYSNIFRWETT 136
           + +NE +R  F +LP  ERL    SC L     ++ + G++++S N+ICF S        
Sbjct: 284 RAKNECYRATF-RLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASK-EEDACH 341

Query: 137 ISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLL 183
           + I L+EVT ++K  ++ ++P+ + I T+S+  F  +   +DR FL+
Sbjct: 342 LIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFA-NLKDRDFLV 387


>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
          Length = 1140

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 35/116 (30%), Positives = 61/116 (52%), Gaps = 10/116 (8%)

Query: 80  KQRNEDFRKLFSKL------PEAERLIVDYSCALQR-EILLQGRLYLSENWICFYSNIFR 132
           ++  E FR+   K       PEAE+L+  YSC   +  +  QG LYLS N +CFYS    
Sbjct: 134 EEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYLSINHLCFYSFFLG 193

Query: 133 WETTISIQLKEVTCLKKEKTAKL-IPNAIQICTESEKHFFTSFGARDRCFLLIFRL 187
            E  + +   ++   K E+T+ + + + I+I T++++  F+ F   D  F ++ +L
Sbjct: 194 KELKLVVPWVDIQ--KLERTSNVFLTDTIRITTQNKERDFSMFLNLDEVFKVMEQL 247



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 24/187 (12%)

Query: 80  KQRNEDFRKLFSKLPEAERLIVDYSCALQREIL---LQGRLYLSENWICFYSNIFRWETT 136
           + +NE FR  F +LP  E+L     C+L          GR++ S+++ICF S        
Sbjct: 281 RAQNEFFRAFF-RLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGC-CK 338

Query: 137 ISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKT 196
           I + L+EV  ++K +   L+P+ I +   S K  F     RDR          ++L+E  
Sbjct: 339 IILPLREVVSIEKMEDTSLLPHPIIVSIRS-KVAFQFIELRDR----------DSLVEAL 387

Query: 197 LSPRELWHLVHQCYGSELGLTSEDEDYVS-PLQLNGLGTPKEVGDVIALSDITSSGAADR 255
           L+  +  H  H  +      TS D+D  S       + +    GD   L  ++S  + + 
Sbjct: 388 LARLKQVHANHPVHYD----TSADDDMASLVFHSTSMCSDHRFGD---LEMMSSQNSEES 440

Query: 256 SQEPSPV 262
            +E SP+
Sbjct: 441 EKEKSPL 447


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 36/138 (26%), Positives = 55/138 (39%), Gaps = 21/138 (15%)

Query: 233 GTPKEVGDVIALSDITSSGAADRSQEP----SPVGSRRGHVTPNLSRASSDADHGAEEDK 288
           GT   + D + LSD   S +    ++P    +P  + +    P  S  SS A+  +  D 
Sbjct: 418 GTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 477

Query: 289 EEQVDSQPDASSS--------QTVTPVAEPPSTEPTQPDGPTTL---------GPLDLLP 331
           +   DS+ ++SSS        +T  P  EPP+T   Q D   T          GP    P
Sbjct: 478 DSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEP 537

Query: 332 SEELLTDTSNSSSSTGEE 349
                    +S S+T +E
Sbjct: 538 PRRHPESKGSSDSATSQE 555


>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
            sapiens]
          Length = 5033

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 8/61 (13%)

Query: 1    MFDTTPHSGRSTPSSSPSLRKRLQL------LPPSRPPPEPEPGTMVEKGSDSSSEKGGV 54
            M DTTP +   TP  SP L+++L +      LPP  P PEPEP    EK    + EK  V
Sbjct: 4452 MGDTTP-AEPPTPEGSPILKRKLGVDGVEEELPPE-PEPEPEPELEPEKADAENGEKEEV 4509

Query: 55   P 55
            P
Sbjct: 4510 P 4510


>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
            sapiens]
          Length = 5038

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 8/61 (13%)

Query: 1    MFDTTPHSGRSTPSSSPSLRKRLQL------LPPSRPPPEPEPGTMVEKGSDSSSEKGGV 54
            M DTTP +   TP  SP L+++L +      LPP  P PEPEP    EK    + EK  V
Sbjct: 4457 MGDTTP-AEPPTPEGSPILKRKLGVDGVEEELPPE-PEPEPEPELEPEKADAENGEKEEV 4514

Query: 55   P 55
            P
Sbjct: 4515 P 4515


>gi|46560555 transmembrane protein 132E [Homo sapiens]
          Length = 984

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 28/105 (26%), Positives = 39/105 (37%), Gaps = 1/105 (0%)

Query: 258 EPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQ 317
           E SP         P        +   ++   + QV  + D SS  +    AE P++ PT 
Sbjct: 859 ELSPPAGNPLETVPAFCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQAEDPASSPTS 918

Query: 318 PDGPTTLGPLDLLPSEELLTDT-SNSSSSTGEEADLAALLPDLSG 361
                       LPSEEL  D+         EE DL    PD++G
Sbjct: 919 KRKRVKFTTFTTLPSEELAYDSVPAGEEDEEEEEDLGWGCPDVAG 963


>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
           sapiens]
          Length = 518

 Score = 37.4 bits (85), Expect = 0.049
 Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 9/82 (10%)

Query: 285 EEDKEEQV---DSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDL-----LPSEELL 336
           E+D E +    D  P +  S+  TP +E  ++E  QP  P   G   +     L S   L
Sbjct: 77  EQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHL 136

Query: 337 TDTSNS-SSSTGEEADLAALLP 357
            D +   S+S+GEEAD  +LLP
Sbjct: 137 DDAAKMPSASSGEEADAGSLLP 158


>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
           sapiens]
          Length = 559

 Score = 37.4 bits (85), Expect = 0.049
 Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 9/82 (10%)

Query: 285 EEDKEEQV---DSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDL-----LPSEELL 336
           E+D E +    D  P +  S+  TP +E  ++E  QP  P   G   +     L S   L
Sbjct: 118 EQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHL 177

Query: 337 TDTSNS-SSSTGEEADLAALLP 357
            D +   S+S+GEEAD  +LLP
Sbjct: 178 DDAAKMPSASSGEEADAGSLLP 199


>gi|151101459 SAPS domain family, member 1 [Homo sapiens]
          Length = 881

 Score = 37.4 bits (85), Expect = 0.049
 Identities = 40/146 (27%), Positives = 59/146 (40%), Gaps = 19/146 (13%)

Query: 204 HLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVG 263
           +L+  CY   +    +DE+     +  G G           SD    GA   SQ     G
Sbjct: 607 NLLEICYKDRIQQFDDDEEEEDEEEAQGSGE----------SD-GEDGAWQGSQLAR--G 653

Query: 264 SRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTT 323
           +R G      S  S+D++   EED+EE+ D +    +++        PS  P QP GP+ 
Sbjct: 654 ARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGP-QPPGPSW 712

Query: 324 LGPLDLLPSEELLTDTSNSSSSTGEE 349
               D +P     TD   S   +GEE
Sbjct: 713 TATFDPVP-----TDAPTSPRVSGEE 733


>gi|154146199 sal-like 3 [Homo sapiens]
          Length = 1300

 Score = 37.0 bits (84), Expect = 0.064
 Identities = 35/107 (32%), Positives = 43/107 (40%), Gaps = 13/107 (12%)

Query: 231 GLGTPKEVGDVIALSDITSSGAADRS-QEPSPVGSRRGHVTPNLSRASSDADHGAEE--- 286
           GL  P  V      +D  S+  A RS Q PSP  S    ++P L+   S     AE    
Sbjct: 527 GLQLPPTVPGAHGYADSPSATPASRSPQRPSPASSECASLSPGLNHVESGVSATAESPQS 586

Query: 287 -------DKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDG-PTTLG 325
                   K E V S P  ++     PV    S  PT  DG PT+LG
Sbjct: 587 LLGGPPLTKAEPV-SLPCTNARAGDAPVGAQASAAPTSVDGAPTSLG 632


>gi|38201677 teashirt family zinc finger 1 [Homo sapiens]
          Length = 1032

 Score = 37.0 bits (84), Expect = 0.064
 Identities = 29/91 (31%), Positives = 39/91 (42%), Gaps = 1/91 (1%)

Query: 269 VTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLD 328
           V  NL   S  +    +  K     S  DAS  ++  P   PP T P    GPTT  P  
Sbjct: 74  VYANLFSESCWSSLALDLKKSGSTTSTNDASQKESSAPTPTPP-TCPVSTTGPTTSTPST 132

Query: 329 LLPSEELLTDTSNSSSSTGEEADLAALLPDL 359
              S    + T+++SSS+G +   AAL   L
Sbjct: 133 SCSSSTSHSSTTSTSSSSGYDWHQAALAKTL 163


>gi|163310725 ER degradation enhancer, mannosidase alpha-like 3
           [Homo sapiens]
          Length = 932

 Score = 37.0 bits (84), Expect = 0.064
 Identities = 25/99 (25%), Positives = 49/99 (49%), Gaps = 7/99 (7%)

Query: 211 GSELGLTSEDEDYVSP--LQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGH 268
           G ++  +S++ D V     + N L +  E    ++L+D+ ++ +   S++ S       H
Sbjct: 817 GEQISSSSQEVDLVDQESSEENSLNSHPES---LSLADMDNAASISPSEQTS--NPTENH 871

Query: 269 VTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPV 307
            T NL+   +D D+  +E  E + DS P+ S  + V P+
Sbjct: 872 ETTNLNGECTDLDNQLQEQSETEEDSNPNVSWGKKVQPI 910


>gi|223468617 family with sequence similarity 75, member C1 [Homo
           sapiens]
          Length = 1188

 Score = 36.6 bits (83), Expect = 0.083
 Identities = 75/275 (27%), Positives = 94/275 (34%), Gaps = 53/275 (19%)

Query: 201 ELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEP- 259
           E W L+ Q   S LG   E  D+    QL+G   P EVG        T  GA+  S EP 
Sbjct: 105 ETWDLLSQLQ-SLLGPHLEKGDFG---QLSGPDPPGEVGKR------TPDGASRSSHEPM 154

Query: 260 -------SPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPS 312
                  SP+ S           AS+               SQP   S     P  EPP+
Sbjct: 155 EDAAPIVSPLASPDPRTKHPQDLASTPPPGPMTTSVSSLSASQPPEPSLLLERPSPEPPA 214

Query: 313 TEPTQPDGPTTLG-----PLDLLP----SEELLTDTSNSS---------SSTGEEADLAA 354
             P  P  P  L      P    P       LLT +   S          S     DLAA
Sbjct: 215 LFPHPPHTPDPLACSPPPPKGFTPPPLRDSTLLTPSHCDSVALPLDTVPQSLSPREDLAA 274

Query: 355 LLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQ---CKFTDVTLSPWSGDSKCH 411
            +P +SG  L  S   V A    Q            +QQ    +  D T+SP        
Sbjct: 275 SVPAISG--LGGSNSQVSALSWSQETTKTWCIFNSSVQQDHLSRQRDTTMSP-------- 324

Query: 412 QRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQA 446
              +L    P+S+ LGP+S   + +   FR  P A
Sbjct: 325 ---LLFQAQPLSH-LGPESQPFISSTPQFRPTPMA 355


>gi|29789008 Huntingtin interacting protein C isoform 2 [Homo
           sapiens]
          Length = 858

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 16/100 (16%)

Query: 7   HSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSS-----EKGGVP----GT 57
           H    +PS S S  + L   PPS  PP+       E GS+ SS     E GG      G+
Sbjct: 694 HKRSHSPSGSESEEEELP--PPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGS 751

Query: 58  PSTQSLGSRNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAE 97
           PS+  LG+ + +R +K      K+R        S  PE+E
Sbjct: 752 PSSHLLGADHGLRKAKKPKKKTKKRRHK-----SNSPESE 786


>gi|72534686 Huntingtin interacting protein C isoform 1 [Homo
           sapiens]
          Length = 871

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 16/100 (16%)

Query: 7   HSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSS-----EKGGVP----GT 57
           H    +PS S S  + L   PPS  PP+       E GS+ SS     E GG      G+
Sbjct: 707 HKRSHSPSGSESEEEELP--PPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGS 764

Query: 58  PSTQSLGSRNFIRNSKMLSPTYKQRNEDFRKLFSKLPEAE 97
           PS+  LG+ + +R +K      K+R        S  PE+E
Sbjct: 765 PSSHLLGADHGLRKAKKPKKKTKKRRHK-----SNSPESE 799


>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
          Length = 851

 Score = 35.8 bits (81), Expect = 0.14
 Identities = 20/53 (37%), Positives = 29/53 (54%), Gaps = 6/53 (11%)

Query: 8   SGRSTPSSSPSLRKRLQLLPPSRPPPE-PEPGTMVEKGSDSSSEKGGVPGTPS 59
           +GR +P+SSP+ ++R   +PP+RP    P PG        + S  GG P  PS
Sbjct: 770 AGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGP-----PPAGSALGGAPPVPS 817


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,509,074
Number of Sequences: 37866
Number of extensions: 1641556
Number of successful extensions: 12730
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 11784
Number of HSP's gapped (non-prelim): 1079
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.