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Search of human proteins with 209969678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 821 0.0
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 564 e-161
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 559 e-159
gi|118402582 cell division cycle 20 [Homo sapiens] 258 9e-69
gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho... 175 7e-44
gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H... 140 2e-33
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 85 1e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 79 7e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 79 1e-14
gi|32189425 WD repeat domain 69 [Homo sapiens] 77 3e-14
gi|16554629 WD repeat domain 5 [Homo sapiens] 76 5e-14
gi|16554627 WD repeat domain 5 [Homo sapiens] 76 5e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 76 5e-14
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 75 1e-13
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 75 1e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 74 2e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 74 3e-13
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 74 3e-13
gi|23199987 WD repeat domain 5B [Homo sapiens] 73 4e-13
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 72 7e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 72 9e-13
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 71 2e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 71 2e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 71 2e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 71 2e-12
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 71 2e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 70 3e-12
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 70 3e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 70 3e-12
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 70 3e-12
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 821 bits (2120), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN
Sbjct: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
Query: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS
Sbjct: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
Query: 121 TPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG 180
TPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG
Sbjct: 121 TPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG 180
Query: 181 HTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLA 240
HTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLA
Sbjct: 181 HTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLA 240
Query: 241 SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 300
SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT
Sbjct: 241 SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 300
Query: 301 GQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYL 360
GQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYL
Sbjct: 301 GQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYL 360
Query: 361 AMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 404
AMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
Sbjct: 361 AMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 404
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 564 bits (1454), Expect = e-161
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA
Sbjct: 219 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 278
Query: 190 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL
Sbjct: 279 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 338
Query: 250 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 309
VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT
Sbjct: 339 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398
Query: 310 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 369
GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI
Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 458
Query: 370 VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 404
VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
Sbjct: 459 VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 493
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 559 bits (1440), Expect = e-159
Identities = 275/278 (98%), Positives = 275/278 (98%), Gaps = 3/278 (1%)
Query: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA
Sbjct: 219 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 278
Query: 190 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL
Sbjct: 279 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 338
Query: 250 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 309
VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT
Sbjct: 339 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398
Query: 310 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 369
GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI
Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 458
Query: 370 VTGAGDETLRFWNVFSKTRSTK---ESVSVLNLFTRIR 404
VTGAGDETLRFWNVFSKTRSTK ESVSVLNLFTRIR
Sbjct: 459 VTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 496
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 258 bits (658), Expect = 9e-69
Identities = 123/259 (47%), Positives = 167/259 (64%), Gaps = 5/259 (1%)
Query: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
+ +L + G+ ++SV W + GN +AVGT VQ+WD K+L + H+ARVG+L+
Sbjct: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275
Query: 190 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
WN+ LSSGSR I D+R L GH QEVCGL+W+ D + LASGGNDN +
Sbjct: 276 WNSYILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
Query: 250 VW----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQ 305
VW P+Q +T+H AVKA+AW P Q +LA+GGGT+DR IR WN +G L
Sbjct: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394
Query: 306 CIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPD 365
+D SQVC++ WS H EL+S HG++QNQ+++WKYP++ +VA+L GH+ RVL L MSPD
Sbjct: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454
Query: 366 GEAIVTGAGDETLRFWNVF 384
G + + A DETLR W F
Sbjct: 455 GATVASAAADETLRLWRCF 473
Score = 45.4 bits (106), Expect = 9e-05
Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 142 SVTSVGWSE-RGNLVAVG--THKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLS 196
+V +V W + N++A G T ++IW+ +G LS ++ H+ +V ++ W+ ++L
Sbjct: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELI 415
Query: 197 SG---SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 253
SG +++++++ + P + L+GH V L S D +AS D L +W
Sbjct: 416 SGHGFAQNQLVIWK---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Query: 254 SSLSPVQQ 261
L P ++
Sbjct: 473 FELDPARR 480
>gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo
sapiens]
Length = 515
Score = 175 bits (443), Expect = 7e-44
Identities = 96/254 (37%), Positives = 139/254 (54%), Gaps = 10/254 (3%)
Query: 135 DLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 194
DLS+ + ++SV W + G +AVGT +G VQ+WD K+L + GH + VGAL+WN
Sbjct: 268 DLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
Query: 195 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254
LSSGSR + D+R Q H+Q VC LKWS D +LL+SG +D L +W H
Sbjct: 328 LSSGSRLGRVYHHDVRV--AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHD 385
Query: 255 SLSPVQ----QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 310
+ Q + AVKA+ W P Q G+LA GGG D + + G+ +Q T
Sbjct: 386 PGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTN 445
Query: 311 SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIV 370
SQ+C+L W E+ + G +N + VW P++++ +GH RVL+LA+SPD +
Sbjct: 446 SQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVF 501
Query: 371 TGAGDETLRFWNVF 384
+ A D T WN +
Sbjct: 502 SAAADGTASVWNCY 515
>gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo
sapiens]
Length = 477
Score = 140 bits (354), Expect = 2e-33
Identities = 85/252 (33%), Positives = 121/252 (48%), Gaps = 44/252 (17%)
Query: 135 DLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 194
DLS+ + ++SV W + G +AVGT +G VQ+WD K+L + GH + VGAL+WN
Sbjct: 268 DLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFI 327
Query: 195 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254
LSSGSR + D+R Q H+Q VC LKWS D +LL+SG +D L +W
Sbjct: 328 LSSGSRLGRVYHHDVRV--AQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW--- 382
Query: 255 SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQ 312
PH G A GQPL+ I T +
Sbjct: 383 ---------------------PHDPGASAQ----------------GQPLKVITQSTAVK 405
Query: 313 VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 372
+C+L W E+ + G +N + VW P++++ GH RVL+LA+SPD + +
Sbjct: 406 ICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLALSPDQTRVFSA 465
Query: 373 AGDETLRFWNVF 384
A D T WN +
Sbjct: 466 AADGTASVWNCY 477
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 84.7 bits (208), Expect = 1e-16
Identities = 77/272 (28%), Positives = 114/272 (41%), Gaps = 52/272 (19%)
Query: 155 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLS-SGSRDRMILQRDIRTPP 213
VA + G V+IWD AG+ +L GHT V L W + L S S+DR I
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
Query: 214 LQSERRLQGHRQEVCGLKWSTDHQL----------------------------------- 238
L R LQGH V + STD+ L
Sbjct: 279 LC--RTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 239 -------LASGGNDNKLLVWNHSS-LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTAD 290
L SG +D L +W+ + P+ + T H A + + +SP ++AS + D
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR-IVASA--SFD 393
Query: 291 RCIRFWNTLTGQPLQCIDTG-SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAK 349
+ I+ W+ TG+ L + + V +AWS + LVS G S + + VW +
Sbjct: 394 KSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVS--GSSDSTLKVWDVKAQKLAMD 451
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 381
L GH+ V + SPDG+ + +G D+ LR W
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 75.5 bits (184), Expect = 8e-14
Identities = 79/311 (25%), Positives = 121/311 (38%), Gaps = 59/311 (18%)
Query: 129 TVTRLCDLSVEGDSVT---------SVGWSERGNLVAVGTHKGFVQIWDAAAGKKLS-ML 178
T R DLS E T S+ WS G +A G G + +WD + GK++ L
Sbjct: 136 TTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL 195
Query: 179 EGHTARVGALAW-------NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 231
GH+ + L+W ++S S+D + D T + ER L GH Q V L+
Sbjct: 196 AGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD--TTAGRCERILTGHTQSVTCLR 253
Query: 232 WSTDHQLLASGGNDNKLLVWNH----------------SSLSPVQQYTEHLAAVKAIAWS 275
W D LL S D + VW ++++ Y A + S
Sbjct: 254 WGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEAS 312
Query: 276 PHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNL-AWS----KHANELVSTHG 330
+ L S +R + +N + GQ + + +GS L WS K ++ H
Sbjct: 313 VNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQ 372
Query: 331 YSQNQIL------------------VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 372
NQ+L +W + +A L GH V +A S D +V+G
Sbjct: 373 ALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSG 432
Query: 373 AGDETLRFWNV 383
+ D TL+ W+V
Sbjct: 433 SSDSTLKVWDV 443
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/111 (36%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
+ V +S +VA + +++WD GK L+ L GH A V +AW+A+ L SGS
Sbjct: 375 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 434
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
D + D++ L + L GH EV + WS D Q +ASGG D L +W
Sbjct: 435 DSTLKVWDVKAQKLAMD--LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 66.2 bits (160), Expect = 5e-11
Identities = 70/263 (26%), Positives = 114/263 (43%), Gaps = 18/263 (6%)
Query: 130 VTRLCDLSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGA 187
VTR C S+EG S V SV +S G +A G+ V+ WD + +GH V +
Sbjct: 103 VTR-CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 188 LAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-----QLLA 240
++W+ + +L+SG ++ IL D T Q R L GH + + GL W H + +A
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 241 SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 300
S D + +W+ ++ + T H +V + W GLL S + DR I+ W
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG--GDGLLYS--ASQDRTIKVWRAHD 276
Query: 301 GQPLQCID-TGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLY 359
G + + G V +A S + + T + + V + +L +
Sbjct: 277 GVLCRTLQGHGHWVNTMALS--TDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
Query: 360 LAMSPDGEAIVTGAGDETLRFWN 382
L E +V+G+ D TL W+
Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWS 357
Score = 42.7 bits (99), Expect = 6e-04
Identities = 17/40 (42%), Positives = 29/40 (72%)
Query: 348 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 387
+ L GHS V+ +A SP G+ + +G+GD T+RFW++ ++T
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET 147
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 79.0 bits (193), Expect = 7e-15
Identities = 71/238 (29%), Positives = 116/238 (48%), Gaps = 14/238 (5%)
Query: 148 WSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE--QLSSGSRDRMIL 205
+S G+L A + V++WD A K L +L+GH V ++++ + QL+SG D+ ++
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 206 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV---QQY 262
D+++ Q R L GHR + +S LA+G D+ + +W+ ++P Q
Sbjct: 131 LWDVQSG--QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL 188
Query: 263 TEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPL-QCIDTGSQVCNLAWSKH 321
H A + + +S GLLASG D+ I W T L Q + V ++A+S
Sbjct: 189 EGHSANISCLCYSAS--GLLASGSW--DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Query: 322 ANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLR 379
L S GYS+ + VW + + L G A +PDG+ +V+GA D+T R
Sbjct: 245 ELWLASA-GYSR-MVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 69.3 bits (168), Expect = 6e-12
Identities = 61/258 (23%), Positives = 116/258 (44%), Gaps = 12/258 (4%)
Query: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
V R+ G V S +S G ++ G+ G V W+ +G+ L L GHT V
Sbjct: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
Query: 190 WNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNK 247
++ + +S S D + D+ + R L+GH++ V + +S D + LASGG D +
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKR 128
Query: 248 LLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPL--- 304
+++W+ S ++ H ++++ +SP + L G+ D + W+ P
Sbjct: 129 VMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT---GSWDSTVHIWDLRMVTPAVSH 185
Query: 305 QCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP 364
Q ++ S N++ ++ + G I +WK + + + +L GH V +A SP
Sbjct: 186 QALEGHS--ANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Query: 365 DGEAIVTGAGDETLRFWN 382
D + + ++ W+
Sbjct: 244 DELWLASAGYSRMVKVWD 261
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
H EV +S D Q+L +G D + W S + + H VK +SP H L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH-LF 78
Query: 283 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQ-VCNLAWSKHANELVSTHGYSQNQILVWKY 341
AS + D +R W+ + L+ + + V +++S + +L S G ++++W
Sbjct: 79 ASA--SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS--GGWDKRVMLWDV 134
Query: 342 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
S + L GH + SP + TG+ D T+ W++
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/130 (26%), Positives = 55/130 (42%), Gaps = 10/130 (7%)
Query: 259 VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCID--TGS-QVCN 315
V+ + +H V + A+SP LL G+ D C+ W T +GQ L + TG + C
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLT---GSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
Query: 316 LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGD 375
+ H S + +W + L GH V ++ SPD + +G D
Sbjct: 71 FSPDGHLFASASC----DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
Query: 376 ETLRFWNVFS 385
+ + W+V S
Sbjct: 127 KRVMLWDVQS 136
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 78.6 bits (192), Expect = 1e-14
Identities = 59/222 (26%), Positives = 105/222 (47%), Gaps = 12/222 (5%)
Query: 165 QIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQG 222
+I D +L +L GH+ V +++ ++ L S S D + ++T +G
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKG 583
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
H V ++S SGG+D +W P++ + HLA V + P+ + +
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 283 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVWK 340
G+ADR +R W+ L G ++ I TG + + +L +S + L + G + ++L+W
Sbjct: 644 T---GSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLAT--GATDGRVLLWD 697
Query: 341 YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 382
V +L GH+ V L S DGE + +G+ D T+R W+
Sbjct: 698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/241 (24%), Positives = 97/241 (40%), Gaps = 15/241 (6%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDR 202
+T+V ++ +L+A G V++W K S+ + A + + S D
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQ---------ASDLSLIDKESDD- 522
Query: 203 MILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 262
+L+R + + L GH V G +S D L S D + +W+ + + + Y
Sbjct: 523 -VLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 263 TEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHA 322
H V +SP+ + ++ G DR R W T QPL+ I G H
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGH---DRVARLWATDHYQPLR-IFAGHLADVNCTRFHP 637
Query: 323 NELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 382
N G + + +W + V TGH + L SP+G + TGA D + W+
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 383 V 383
+
Sbjct: 698 I 698
Score = 38.5 bits (88), Expect = 0.011
Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSR 200
+ S+ +S G +A G G V +WD G + L+GHT V +L + + E L+SGS
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM 731
Query: 201 DRMI 204
D +
Sbjct: 732 DNTV 735
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 77.0 bits (188), Expect = 3e-14
Identities = 50/233 (21%), Positives = 107/233 (45%), Gaps = 8/233 (3%)
Query: 152 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDI 209
G+ +A G+ ++W GK GHTA + L++N + +++GS D DI
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 210 RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAV 269
+ + L+GH E+ L ++T + +G D+ ++VW+ + V H A +
Sbjct: 207 QNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 270 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTH 329
+ +++ +L G+ D+ + W+ G+ + + + + +L++T
Sbjct: 265 SSASFNWDCSLILT---GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 330 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 382
+ ++ + +AKL GH + ++ +P G ++TG+ D+T R W+
Sbjct: 322 S-ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 67.8 bits (164), Expect = 2e-11
Identities = 52/242 (21%), Positives = 113/242 (46%), Gaps = 10/242 (4%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLSSGSR 200
+ + ++ + LVA G+ ++WD G+++ L GH+A + +L++N +++ +GS
Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF 239
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D ++ D T + L GH E+ ++ D L+ +G D +W+ ++ V
Sbjct: 240 DHTVVVWDADTG--RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWS 319
T H + + + L+A+ +AD R ++ T + + ++ ++ ++++
Sbjct: 298 TLTGHDDEILDSCFD-YTGKLIATA--SADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
Query: 320 KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLR 379
N L++ G S +W + + L GH+ + A + G ++TG+ D T R
Sbjct: 355 PQGNHLLT--GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Query: 380 FW 381
W
Sbjct: 413 IW 414
Score = 48.9 bits (115), Expect = 8e-06
Identities = 30/118 (25%), Positives = 56/118 (47%), Gaps = 4/118 (3%)
Query: 136 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-- 193
L+ D + + G L+A + G +I+ AA K ++ LEGH + +++N +
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 194 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
L +GS D+ D +T Q + L+GH E+ ++ ++ +G DN +W
Sbjct: 359 HLLTGSSDKTARIWDAQTG--QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 44.3 bits (103), Expect = 2e-04
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 4/75 (5%)
Query: 131 TRLCDLSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGAL 188
TR C +EG ++ + ++ +GN + G+ +IWDA G+ L +LEGHT + +
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC 393
Query: 189 AWN--AEQLSSGSRD 201
A+N + +GS+D
Sbjct: 394 AFNYKGNIVITGSKD 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 76.3 bits (186), Expect = 5e-14
Identities = 62/249 (24%), Positives = 112/249 (44%), Gaps = 18/249 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
++ V WS NL+ + ++IWD ++GK L L+GH+ V +N + + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D + D++T + + L H V + ++ D L+ S D +W+ +S ++
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 261 Q-YTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 319
+ V + +SP+ +LA+ T D ++ W+ G +C+ T + N +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKG---KCLKTYTGHKNEKYC 261
Query: 320 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 373
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 374 -GDETLRFW 381
D+T++ W
Sbjct: 322 ENDKTIKLW 330
Score = 71.2 bits (173), Expect = 2e-12
Identities = 75/314 (23%), Positives = 134/314 (42%), Gaps = 38/314 (12%)
Query: 110 PQTEDRRLQPS----------TPEKKGL---FTVTRLCDLSVEGDSVTSVGWSERGNLVA 156
P+TE R QP+ TP K FT L+ +V+SV +S G +A
Sbjct: 8 PETEAARAQPTPSSSATQSKPTPVKPNYALKFT------LAGHTKAVSSVKFSPNGEWLA 61
Query: 157 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPL 214
+ ++IW A GK + GH + +AW+++ L S S D+ + D+ +
Sbjct: 62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-- 119
Query: 215 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAW 274
+ + L+GH V ++ L+ SG D + +W+ + ++ H V A+ +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 275 SPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLAWSKHANELVSTHGYS 332
+ +++S + D R W+T +GQ L+ + D V + +S + +++
Sbjct: 180 NRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA--ATL 234
Query: 333 QNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 389
N + +W Y + TGH Y + G+ IV+G+ D + WN+
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-----Q 289
Query: 390 TKESVSVLNLFTRI 403
TKE V L T +
Sbjct: 290 TKEIVQKLQGHTDV 303
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 76.3 bits (186), Expect = 5e-14
Identities = 62/249 (24%), Positives = 112/249 (44%), Gaps = 18/249 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
++ V WS NL+ + ++IWD ++GK L L+GH+ V +N + + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D + D++T + + L H V + ++ D L+ S D +W+ +S ++
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 261 Q-YTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 319
+ V + +SP+ +LA+ T D ++ W+ G +C+ T + N +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKG---KCLKTYTGHKNEKYC 261
Query: 320 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 373
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 374 -GDETLRFW 381
D+T++ W
Sbjct: 322 ENDKTIKLW 330
Score = 71.2 bits (173), Expect = 2e-12
Identities = 75/314 (23%), Positives = 134/314 (42%), Gaps = 38/314 (12%)
Query: 110 PQTEDRRLQPS----------TPEKKGL---FTVTRLCDLSVEGDSVTSVGWSERGNLVA 156
P+TE R QP+ TP K FT L+ +V+SV +S G +A
Sbjct: 8 PETEAARAQPTPSSSATQSKPTPVKPNYALKFT------LAGHTKAVSSVKFSPNGEWLA 61
Query: 157 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPL 214
+ ++IW A GK + GH + +AW+++ L S S D+ + D+ +
Sbjct: 62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-- 119
Query: 215 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAW 274
+ + L+GH V ++ L+ SG D + +W+ + ++ H V A+ +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 275 SPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLAWSKHANELVSTHGYS 332
+ +++S + D R W+T +GQ L+ + D V + +S + +++
Sbjct: 180 NRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA--ATL 234
Query: 333 QNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 389
N + +W Y + TGH Y + G+ IV+G+ D + WN+
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-----Q 289
Query: 390 TKESVSVLNLFTRI 403
TKE V L T +
Sbjct: 290 TKEIVQKLQGHTDV 303
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.3 bits (186), Expect = 5e-14
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 12/220 (5%)
Query: 168 DAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQ 225
D AG ++ +L GH V + + A+ L S S D I D+ + + QGH
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS--FTNTVLYQGHAY 385
Query: 226 EVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASG 285
V L S ASG +D +W+ P++ Y HLA V + + P+ + L
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT-- 443
Query: 286 GGTADRCIRFWNTLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVWKYPS 343
G+ D+ +R W+ G ++ TG + V +LA+S + L S ++ +W S
Sbjct: 444 -GSTDKTVRLWSAQQGNSVRLF-TGHRGPVLSLAFSPNGKYLASAG--EDQRLKLWDLAS 499
Query: 344 LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
T +L GH+ + L SPD I + + D ++R W++
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 57.0 bits (136), Expect = 3e-08
Identities = 47/184 (25%), Positives = 82/184 (44%), Gaps = 18/184 (9%)
Query: 156 AVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPP 213
A G+H ++W L + GH A V + + N+ L++GS D+ + R
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV--RLWSAQQ 457
Query: 214 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 273
S R GHR V L +S + + LAS G D +L +W+ +S + ++ H + ++
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 274 WSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQ 333
+SP GL+AS + D +R W D + C+ ++ELV +
Sbjct: 518 FSP-DSGLIAS--ASMDNSVRVW-----------DIRNTYCSAPADGSSSELVGVYTGQM 563
Query: 334 NQIL 337
+ +L
Sbjct: 564 SNVL 567
Score = 56.6 bits (135), Expect = 4e-08
Identities = 45/168 (26%), Positives = 67/168 (39%), Gaps = 4/168 (2%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 279
L+GH V ++ D L S D + W+ S + Y H V + SP+
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS- 396
Query: 280 GLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 339
L G+ DR R W+ PL+ I G H N G + + +W
Sbjct: 397 --LYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
Query: 340 KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 387
V TGH VL LA SP+G+ + + D+ L+ W++ S T
Sbjct: 454 SAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT 501
Score = 55.8 bits (133), Expect = 7e-08
Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 4/112 (3%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSR 200
V V + N +A G+ V++W A G + + GH V +LA+ N + L+S
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
D+ + D+ + L E L+GH + L +S D L+AS DN + VW+
Sbjct: 489 DQRLKLWDLASGTLYKE--LRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 35.4 bits (80), Expect = 0.093
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
V S+ +S G +A +++WD A+G L GHT + +L ++ + ++S S
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASM 530
Query: 201 DRMILQRDIR 210
D + DIR
Sbjct: 531 DNSVRVWDIR 540
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 75.1 bits (183), Expect = 1e-13
Identities = 66/263 (25%), Positives = 111/263 (42%), Gaps = 15/263 (5%)
Query: 128 FTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM-LEGHTA 183
+T ++ + + V + ++ GN VA G I++ + ++S L GHT
Sbjct: 85 YTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTG 144
Query: 184 RVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASG 242
+ + + Q+ + S D DI T Q GH +V L S D + SG
Sbjct: 145 YLSCCRFLDDSQIVTSSGDTTCALWDIETA--QQTTTFTGHSGDVMSLSLSPDMRTFVSG 202
Query: 243 GNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 302
D +W+ Q +T H++ + A+++ P+ + A G+ D R ++ Q
Sbjct: 203 ACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGY---AFATGSDDATCRLFDLRADQ 259
Query: 303 PLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLY 359
L + +C + A+SK L++ GY VW + L GH RV
Sbjct: 260 ELLLYSHDNIICGITSVAFSKSGRLLLA--GYDDFNCNVWDTLKGDRAGVLAGHDNRVSC 317
Query: 360 LAMSPDGEAIVTGAGDETLRFWN 382
L ++ DG A+ TG+ D LR WN
Sbjct: 318 LGVTDDGMAVATGSWDSFLRIWN 340
Score = 62.0 bits (149), Expect = 9e-10
Identities = 40/171 (23%), Positives = 74/171 (43%), Gaps = 3/171 (1%)
Query: 214 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 273
+++ R L+GH ++ + W D +LL S D KL++W+ + + + + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCA 104
Query: 274 WSPHQHGLLASGGGTADRC-IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYS 332
++P G + GG + C I T G + L+ + ++
Sbjct: 105 YAP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG 162
Query: 333 QNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
+W + Q TGHS V+ L++SPD V+GA D + + W++
Sbjct: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI 213
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 74.7 bits (182), Expect = 1e-13
Identities = 61/251 (24%), Positives = 110/251 (43%), Gaps = 19/251 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + + S
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D+ + D T +++++ H + W +++ AS D + V P++
Sbjct: 287 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIK 343
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 319
+ H V AI W P LLAS + D ++ W+ + + ++ + WS
Sbjct: 344 TFQGHTNEVNAIKWDP-TGNLLAS--CSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Query: 320 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 371
+AN ++++ + + + +W + LT H V +A SPDG + +
Sbjct: 401 PTGPGTNNPNANLMLASASF-DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459
Query: 372 GAGDETLRFWN 382
G+ D+ + WN
Sbjct: 460 GSFDKCVHIWN 470
Score = 49.7 bits (117), Expect = 5e-06
Identities = 47/222 (21%), Positives = 93/222 (41%), Gaps = 17/222 (7%)
Query: 163 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 222
F+ W+ + S TAR+ WN + S+ +++L+ IR + + +
Sbjct: 173 FICAWNPVSDLLASGSGDSTARI----WNLSENSTSGSTQLVLRHCIR----EGGQDVPS 224
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
++ +V L W+++ LLA+G D +W + +H + A+ W+ + +L
Sbjct: 225 NK-DVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282
Query: 283 ASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQILVWKY 341
++G D+ W+ TG+ Q S ++ W + N S + I V K
Sbjct: 283 SAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NTFASCS--TDMCIHVCKL 336
Query: 342 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
+ GH+ V + P G + + + D TL+ W++
Sbjct: 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSM 378
Score = 43.1 bits (100), Expect = 4e-04
Identities = 35/179 (19%), Positives = 65/179 (36%), Gaps = 36/179 (20%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSR 200
+ V ++ W GNL+A + ++IW + L+ H + + W+
Sbjct: 350 NEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP-------- 401
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
T P G + +LAS D+ + +W+ +
Sbjct: 402 ----------TGP---------------GTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 319
T+H V ++A+SP L G+ D+C+ WNT TG + + + W+
Sbjct: 437 TLTKHQEPVYSVAFSPDGRYL---ASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWN 492
Score = 34.3 bits (77), Expect = 0.21
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 389
L GH V A +P + + +G+GD T R WN+ + S
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTS 204
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 73.9 bits (180), Expect = 2e-13
Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 30/264 (11%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSG 198
DSV + + G L+A + +++WD + + + GH V ++A N + + S
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA 210
Query: 199 SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSP 258
SRD+ I +++T + GHR+ V ++ + D L+AS ND + VW ++
Sbjct: 211 SRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC 268
Query: 259 VQQYTEHLAAVKAIAWSPHQHGLLASG-----------------GGTADRCIRFWNTLTG 301
+ EH V+ I+W+P S G+ D+ I+ W+ TG
Sbjct: 269 KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328
Query: 302 QPLQCIDTGSQVCNLAWSK----HANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRV 357
L + V + W + H+ + VW Y + + L H + V
Sbjct: 329 MCLMTL-----VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383
Query: 358 LYLAMSPDGEAIVTGAGDETLRFW 381
L +VTG+ D+T++ W
Sbjct: 384 TSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 50.4 bits (119), Expect = 3e-06
Identities = 45/171 (26%), Positives = 77/171 (45%), Gaps = 12/171 (7%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 279
L GHR V + + ++ S D + VW++ + + H +V+ I++ H
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSG 162
Query: 280 GLLASGGGTADRCIRFWNTLTGQPLQCIDT----GSQVCNLAWSKHANELVSTHGYSQNQ 335
LLAS +AD I+ W+ Q +CI T V ++A + + +VS
Sbjct: 163 KLLASC--SADMTIKLWDF---QGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS--RDKT 215
Query: 336 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 386
I +W+ + V TGH V + + DG I + + D+T+R W V +K
Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
Score = 47.8 bits (112), Expect = 2e-05
Identities = 46/228 (20%), Positives = 93/228 (40%), Gaps = 28/228 (12%)
Query: 178 LEGHTARVGALAWNA--EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 235
L GH + V + ++ + S S D I D T ER L+GH V + +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--ERTLKGHTDSVQDISFDHS 161
Query: 236 HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF 295
+LLAS D + +W+ ++ H V ++A P+ ++++ + D+ I+
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA---SRDKTIKM 218
Query: 296 WNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSY 355
W TG ++ + + L+++ Q + VW + A+L H +
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT-VRVWVVATKECKAELREHEH 277
Query: 356 RVLYLAMSPD--------------------GEAIVTGAGDETLRFWNV 383
V ++ +P+ G +++G+ D+T++ W+V
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 3e-13
Identities = 59/250 (23%), Positives = 105/250 (42%), Gaps = 9/250 (3%)
Query: 129 TVTRLCDLSVEGDSVTSVGWSER-GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGA 187
T +L ++ +V+S+ + G L+A G V +W + L GHT+ V +
Sbjct: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68
Query: 188 LAWNA--EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGND 245
+ N E + +GS+ I D+ + R L GH+ +C L + + +ASG D
Sbjct: 69 VRLNTPEELIVAGSQSGSIRVWDLEAAKIL--RTLMGHKANICSLDFHPYGEFVASGSQD 126
Query: 246 NKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQ 305
+ +W+ V +Y H AV+ + +SP L ++ D ++ W+ G+ +
Sbjct: 127 TNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD---DHTVKLWDLTAGKMMS 183
Query: 306 CIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPD 365
+ N+ H NE + G S I W V+ + G V + +PD
Sbjct: 184 EFPGHTGPVNVV-EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPD 242
Query: 366 GEAIVTGAGD 375
G + +G D
Sbjct: 243 GCCLYSGCQD 252
Score = 57.0 bits (136), Expect = 3e-08
Identities = 36/148 (24%), Positives = 74/148 (50%), Gaps = 6/148 (4%)
Query: 237 QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 296
+LLA+GG+D ++ +W+ + + + T H + V+++ + + ++A G+ IR W
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVA---GSQSGSIRVW 90
Query: 297 NTLTGQPLQCI-DTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSY 355
+ + L+ + + +C+L + + + S G I +W V + GHS
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVAS--GSQDTNIKLWDIRRKGCVFRYRGHSQ 148
Query: 356 RVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V L SPDG+ + + A D T++ W++
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDL 176
Score = 38.1 bits (87), Expect = 0.014
Identities = 28/129 (21%), Positives = 50/129 (38%), Gaps = 5/129 (3%)
Query: 259 VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC-IRFWNTLTGQPLQCIDTGSQVCNLA 317
+Q+ H + V ++ LLA+GG D C + W+ + + +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGG---DDCRVNLWSINKPNCIMSLTGHTSPVESV 69
Query: 318 WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDET 377
EL+ G I VW + + L GH + L P GE + +G+ D
Sbjct: 70 RLNTPEELIVA-GSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTN 128
Query: 378 LRFWNVFSK 386
++ W++ K
Sbjct: 129 IKLWDIRRK 137
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 73.6 bits (179), Expect = 3e-13
Identities = 80/338 (23%), Positives = 138/338 (40%), Gaps = 28/338 (8%)
Query: 66 ENEKSPSQNRKAKDATSD-------NGKDGLAYSALLKNELLGAGIEKVQDPQ--TEDRR 116
E E+ +Q R A+ A +D N D + + L + K+ T+ R
Sbjct: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 117 LQPSTPEKKGL----FTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG 172
L ++ + K + +T ++ + + V + ++ GN VA G I++
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 173 K---KLSM-LEGHTARVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEV 227
+ ++S L GHT + + + Q+ + S D DI T Q GH +V
Sbjct: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDV 187
Query: 228 CGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGG 287
L + D +L SG D +W+ Q +T H + + AI + P+ + A G
Sbjct: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN---AFATG 244
Query: 288 TADRCIRFWNTLTGQPLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSL 344
+ D R ++ Q L + +C + ++SK L++ GY VW
Sbjct: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFNCNVWDALKA 302
Query: 345 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 382
+ L GH RV L ++ DG A+ TG+ D L+ WN
Sbjct: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 19/179 (10%)
Query: 214 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 273
+++ R L+GH ++ + W TD +LL S D KL++W+ + + V + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 274 WSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQ 333
++P +A GG D +N T + G+ + + H L
Sbjct: 105 YAP-SGNYVACGG--LDNICSIYNLKTRE-------GNVRVSRELAGHTGYLSCCRFLDD 154
Query: 334 NQIL---------VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
NQI+ +W + Q TGH+ V+ L+++PD V+GA D + + W+V
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 73.2 bits (178), Expect = 4e-13
Identities = 68/277 (24%), Positives = 122/277 (44%), Gaps = 19/277 (6%)
Query: 134 CDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE 193
C L ++V+SV +S G +A + + IW A GK L GH + +AW+++
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 194 --QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
+L S S D+ + D+R+ + + L+GH V ++ L+ SG D + +W
Sbjct: 95 SSRLVSASDDKTLKLWDVRSG--KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 252 NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DT 309
+ ++ + H V A+ ++ L+ S G+ D R W+ +GQ L+ + D
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFN-CSGSLIVS--GSYDGLCRIWDAASGQCLKTLVDDD 209
Query: 310 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDG 366
V + +S + +++ N + +W Y + TGH Y + G
Sbjct: 210 NPPVSFVKFSPNGKYILT--ATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG 267
Query: 367 EAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRI 403
+ IV+G+ D + WN+ TKE V L T +
Sbjct: 268 KWIVSGSEDNLVYIWNL-----QTKEIVQKLQGHTDV 299
Score = 67.4 bits (163), Expect = 2e-11
Identities = 57/249 (22%), Positives = 109/249 (43%), Gaps = 18/249 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 200
++ V WS + + + +++WD +GK L L+GH+ V +N + + SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D + +++T + + L H V + ++ L+ SG D +W+ +S ++
Sbjct: 146 DETVKIWEVKTG--KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 261 QYTEH-LAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 319
+ V + +SP+ +L + T D ++ W+ G+ C+ T + N +
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTA---TLDNTLKLWDYSRGR---CLKTYTGHKNEKYC 257
Query: 320 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 373
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAL 317
Query: 374 -GDETLRFW 381
D+T++ W
Sbjct: 318 ENDKTIKLW 326
Score = 55.1 bits (131), Expect = 1e-07
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 21/173 (12%)
Query: 136 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSML---EGHTARVGALAWNA 192
LS D V++V ++ G+L+ G++ G +IWDAA+G+ L L + + N
Sbjct: 163 LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNG 222
Query: 193 EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE---------VCGLKWSTDHQLLASGG 243
+ + + + D + D + + GH+ E V G KW + SG
Sbjct: 223 KYILTATLDNTLKLWDYSRG--RCLKTYTGHKNEKYCIFANFSVTGGKW------IVSGS 274
Query: 244 NDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 296
DN + +WN + VQ+ H V + A P ++ L+AS D+ I+ W
Sbjct: 275 EDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 72.4 bits (176), Expect = 7e-13
Identities = 66/263 (25%), Positives = 109/263 (41%), Gaps = 15/263 (5%)
Query: 128 FTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM-LEGHTA 183
+T ++ + + V + ++ GN VA G I++ + + K+S L HT
Sbjct: 85 YTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTG 144
Query: 184 RVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASG 242
+ + + + + S D DI T Q + GH + L S D L SG
Sbjct: 145 YLSCCRFLDDNNIVTSSGDTTCALWDIETG--QQKTVFVGHTGDCMSLAVSPDFNLFISG 202
Query: 243 GNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 302
D +W+ + Q +T H + + AI + P+ + G+ D R ++ Q
Sbjct: 203 ACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICT---GSDDASCRLFDLRADQ 259
Query: 303 PLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLY 359
L C S +C + A+S L + GY VW +V L+GH RV
Sbjct: 260 ELICFSHESIICGITSVAFSLSGRLLFA--GYDDFNCNVWDSMKSERVGILSGHDNRVSC 317
Query: 360 LAMSPDGEAIVTGAGDETLRFWN 382
L ++ DG A+ TG+ D L+ WN
Sbjct: 318 LGVTADGMAVATGSWDSFLKIWN 340
Score = 62.0 bits (149), Expect = 9e-10
Identities = 44/176 (25%), Positives = 76/176 (43%), Gaps = 13/176 (7%)
Query: 214 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 273
+++ R L+GH ++ + W+TD +LL S D KL+VW+ + + V + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 274 WSPHQHGLLASGGGTADRC------IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVS 327
++P G + GG + C R N + L C N +V+
Sbjct: 105 YAP--SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL---DDNNIVT 159
Query: 328 THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
+ G +W + Q GH+ + LA+SPD ++GA D + + W+V
Sbjct: 160 SSG--DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 72.0 bits (175), Expect = 9e-13
Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 19/228 (8%)
Query: 162 GFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRL- 220
G V++W + + ++ +EGHT RV + W+ G+ R R L+++ +
Sbjct: 303 GSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT---CYDRSWRLWDLEAQEEIL 359
Query: 221 --QGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 278
+GH V + + D L +GG D VW+ + + HL + I +SP+
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
Query: 279 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSK-----HANELVSTHGYSQ 333
+ + G+ D + W+ + +C+ T NL H N L++ G
Sbjct: 420 YHIAT---GSGDNTCKVWDL---RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT--GAYD 471
Query: 334 NQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 381
N +W +P + + L GH +V+ L +S DG+ I T + D T + W
Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 55.5 bits (132), Expect = 9e-08
Identities = 66/337 (19%), Positives = 118/337 (35%), Gaps = 70/337 (20%)
Query: 66 ENEKSPSQNRKAKDATSDNGKDGLAYSAL-LKNELLGAGIEKVQDPQTEDRRLQPSTPEK 124
++EKS + + G + L + L + N L ++++ E+ RL PE
Sbjct: 151 DDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRL-----EEARLHKEIPET 205
Query: 125 ----------KGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK 174
K L ++ C + ++ +S ++A G ++W
Sbjct: 206 TRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNL 265
Query: 175 LSMLEGHTARVGALAWNAEQLSSGSRDRMILQR-----DIRTPPLQSERR---LQGHRQE 226
L L GH VGA+ ++ + S + L ++ L S+ ++GH
Sbjct: 266 LHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVR 325
Query: 227 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG 286
V + W + L + D +W+ + + H V IA+ HQ G LA G
Sbjct: 326 VARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAF--HQDGSLAGTG 383
Query: 287 GTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQ 346
G D R W+ TG+ + ++
Sbjct: 384 GL-DAFGRVWDLRTGRCIMFLE-------------------------------------- 404
Query: 347 VAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
GH + + SP+G I TG+GD T + W++
Sbjct: 405 -----GHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
Score = 54.3 bits (129), Expect = 2e-07
Identities = 39/146 (26%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 136 LSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--N 191
L EG S V + + + G+L G F ++WD G+ + LEGH + + + N
Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418
Query: 192 AEQLSSGSRDRMILQRDIRTPPLQSERR----LQGHRQEVCGLKWSTDH-QLLASGGNDN 246
+++GS D D+R +RR + H+ V G+K+ H L +G DN
Sbjct: 419 GYHIATGSGDNTCKVWDLR------QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472
Query: 247 KLLVWNHSSLSPVQQYTEHLAAVKAI 272
+W H SP++ H V +
Sbjct: 473 TAKIWTHPGWSPLKTLAGHEGKVMGL 498
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 200
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 299 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 355
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 319
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 356 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 320 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 371
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 413 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 372 GAGDETLRFWNVFS 385
G+ D+ + WN S
Sbjct: 472 GSFDKCVHIWNTQS 485
Score = 52.4 bits (124), Expect = 7e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 163 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 222
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 185 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 231
Query: 223 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 278
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 290
Query: 279 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 337
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 291 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 344
Query: 338 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 13/133 (9%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE------- 193
+ V ++ W G L+A + ++IW + L+ H + + W+
Sbjct: 362 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 421
Query: 194 ----QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
L+S S D + DI L H++ V + +S D + LASG D +
Sbjct: 422 NSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479
Query: 250 VWNHSSLSPVQQY 262
+WN S + V Y
Sbjct: 480 IWNTQSGNLVHSY 492
Score = 33.5 bits (75), Expect = 0.35
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
L GH V A +P + + +G+GD T R WN+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 210
Score = 32.3 bits (72), Expect = 0.78
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
L+GH EV W+ LLASG D+ +WN
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 200
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 299 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 355
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 319
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 356 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 320 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 371
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 413 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 372 GAGDETLRFWNVFS 385
G+ D+ + WN S
Sbjct: 472 GSFDKCVHIWNTQS 485
Score = 52.4 bits (124), Expect = 7e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 163 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 222
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 185 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 231
Query: 223 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 278
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 290
Query: 279 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 337
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 291 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 344
Query: 338 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 13/133 (9%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE------- 193
+ V ++ W G L+A + ++IW + L+ H + + W+
Sbjct: 362 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 421
Query: 194 ----QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
L+S S D + DI L H++ V + +S D + LASG D +
Sbjct: 422 NSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479
Query: 250 VWNHSSLSPVQQY 262
+WN S + V Y
Sbjct: 480 IWNTQSGNLVHSY 492
Score = 33.5 bits (75), Expect = 0.35
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
L GH V A +P + + +G+GD T R WN+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 210
Score = 32.3 bits (72), Expect = 0.78
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
L+GH EV W+ LLASG D+ +WN
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 200
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 350 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 319
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 407 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 320 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 371
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 464 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 372 GAGDETLRFWNVFS 385
G+ D+ + WN S
Sbjct: 523 GSFDKCVHIWNTQS 536
Score = 52.4 bits (124), Expect = 7e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 163 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 222
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 236 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 282
Query: 223 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 278
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 341
Query: 279 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 337
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 342 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 395
Query: 338 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 13/133 (9%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE------- 193
+ V ++ W G L+A + ++IW + L+ H + + W+
Sbjct: 413 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 472
Query: 194 ----QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
L+S S D + DI L H++ V + +S D + LASG D +
Sbjct: 473 NSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
Query: 250 VWNHSSLSPVQQY 262
+WN S + V Y
Sbjct: 531 IWNTQSGNLVHSY 543
Score = 33.5 bits (75), Expect = 0.35
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
L GH V A +P + + +G+GD T R WN+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 261
Score = 32.3 bits (72), Expect = 0.78
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
L+GH EV W+ LLASG D+ +WN
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 200
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 260
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 350 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
Query: 261 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 319
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 407 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 320 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 371
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 464 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 372 GAGDETLRFWNVFS 385
G+ D+ + WN S
Sbjct: 523 GSFDKCVHIWNTQS 536
Score = 52.4 bits (124), Expect = 7e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 163 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 222
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 236 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 282
Query: 223 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 278
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 341
Query: 279 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 337
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 342 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 395
Query: 338 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 13/133 (9%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE------- 193
+ V ++ W G L+A + ++IW + L+ H + + W+
Sbjct: 413 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 472
Query: 194 ----QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
L+S S D + DI L H++ V + +S D + LASG D +
Sbjct: 473 NSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
Query: 250 VWNHSSLSPVQQY 262
+WN S + V Y
Sbjct: 531 IWNTQSGNLVHSY 543
Score = 33.5 bits (75), Expect = 0.35
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 350 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
L GH V A +P + + +G+GD T R WN+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 261
Score = 32.3 bits (72), Expect = 0.78
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 220 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
L+GH EV W+ LLASG D+ +WN
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/111 (36%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 143 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 200
+ V +S +VA + +++WD GK L+ L GH A V +AW+A+ L SGS
Sbjct: 83 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 142
Query: 201 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
D + D++ L + L GH EV + WS D Q +ASGG D L +W
Sbjct: 143 DSTLKVWDVKAQKLAMD--LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 65.5 bits (158), Expect = 8e-11
Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 7/145 (4%)
Query: 239 LASGGNDNKLLVWNHSS-LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 297
L SG +D L +W+ + P+ + T H A + + +SP ++AS + D+ I+ W+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR-IVASA--SFDKSIKLWD 108
Query: 298 TLTGQPLQCIDTG-SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 356
TG+ L + + V +AWS + LVS G S + + VW + L GH+
Sbjct: 109 GRTGKYLASLRGHVAAVYQIAWSADSRLLVS--GSSDSTLKVWDVKAQKLAMDLPGHADE 166
Query: 357 VLYLAMSPDGEAIVTGAGDETLRFW 381
V + SPDG+ + +G D+ LR W
Sbjct: 167 VYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 64.3 bits (155), Expect = 2e-10
Identities = 44/134 (32%), Positives = 67/134 (50%), Gaps = 8/134 (5%)
Query: 166 IWDAAAGKK-LSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQG 222
+W A KK L+ + GH A + + ++ + ++S S D+ I D RT + L+G
Sbjct: 63 LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS--LRG 120
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
H V + WS D +LL SG +D+ L VW+ + H V A+ WSP +
Sbjct: 121 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ-RV 179
Query: 283 ASGGGTADRCIRFW 296
ASGG D+C+R W
Sbjct: 180 ASGG--KDKCLRIW 191
Score = 38.9 bits (89), Expect = 0.008
Identities = 18/65 (27%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 142 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGS 199
+V + WS L+ G+ +++WD A K L GH V A+ W + ++++SG
Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 183
Query: 200 RDRMI 204
+D+ +
Sbjct: 184 KDKCL 188
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 70.5 bits (171), Expect = 3e-12
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 18/248 (7%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSR 200
D+VT V +S G+L+A G+ V+IW + ++ HTA V ++ + ++ S
Sbjct: 24 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS---- 79
Query: 201 DRMILQRDIRTPPLQSERR------LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254
+ D +T + + R L H V K+S D +L+ S +D + +W+ S
Sbjct: 80 --FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 255 SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVC 314
S V Y EH V + + P + A+G D ++ W+ T + LQ S
Sbjct: 138 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAG---MDNTVKVWDVRTHRLLQHYQLHSAAV 194
Query: 315 N-LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 373
N L++ N L++ S +IL L + L GH +A S GE +G
Sbjct: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRL--LYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 374 GDETLRFW 381
DE + W
Sbjct: 253 SDEQVMVW 260
Score = 48.9 bits (115), Expect = 8e-06
Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 6/143 (4%)
Query: 245 DNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW-NTLTGQP 303
D+ L+VW+ S ++T H AV + +SP H LLASG + D+ +R W + G+
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH-LLASG--SRDKTVRIWVPNVKGES 58
Query: 304 LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 363
+ V ++ + V+ + VW + L+ H V S
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 116
Query: 364 PDGEAIVTGAGDETLRFWNVFSK 386
PDG IV+ + D+T++ W+ S+
Sbjct: 117 PDGRLIVSASDDKTVKLWDKSSR 139
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/172 (21%), Positives = 64/172 (37%), Gaps = 6/172 (3%)
Query: 213 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAI 272
P R GH+ V + +S LLASG D + +W + + H A V+++
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 71
Query: 273 AWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLA-WSKHANELVSTHGY 331
+ + + + D+ ++ W T + L + A +S +VS
Sbjct: 72 HFCSDGQSFVTA---SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS-- 126
Query: 332 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
+ +W S V H V Y+ P G I D T++ W+V
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 43.1 bits (100), Expect = 4e-04
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 4/114 (3%)
Query: 140 GDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSS 197
G VT V + G +A V++WD + L + H+A V L++ + L +
Sbjct: 149 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 208
Query: 198 GSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
S D + D+ L L GH+ + +S + ASGG+D +++VW
Sbjct: 209 ASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 37.4 bits (85), Expect = 0.024
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 336 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRST 390
++VW ++ + TGH V + SP G + +G+ D+T+R W K ST
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 70.5 bits (171), Expect = 3e-12
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 18/248 (7%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSR 200
D+VT V +S G+L+A G+ V+IW + ++ HTA V ++ + ++ S
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS---- 117
Query: 201 DRMILQRDIRTPPLQSERR------LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254
+ D +T + + R L H V K+S D +L+ S +D + +W+ S
Sbjct: 118 --FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 255 SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVC 314
S V Y EH V + + P + A+G D ++ W+ T + LQ S
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAG---MDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 315 N-LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 373
N L++ N L++ S +IL L + L GH +A S GE +G
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRL--LYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 374 GDETLRFW 381
DE + W
Sbjct: 291 SDEQVMVW 298
Score = 67.0 bits (162), Expect = 3e-11
Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 6/171 (3%)
Query: 217 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSP 276
ER +GHR V + +S + + LASG D+ L+VW+ S ++T H AV + +SP
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 277 HQHGLLASGGGTADRCIRFW-NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQ 335
H LLAS G+ D+ +R W + G+ + V ++ + V+
Sbjct: 72 SGH-LLAS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKT 126
Query: 336 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 386
+ VW + L+ H V SPDG IV+ + D+T++ W+ S+
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 53.1 bits (126), Expect = 4e-07
Identities = 44/194 (22%), Positives = 77/194 (39%), Gaps = 8/194 (4%)
Query: 191 NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLV 250
N +QL+SGS D ++ ++ P R GH+ V + +S LLASG D + +
Sbjct: 30 NTKQLASGSMDSCLMVWHMK--PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRI 87
Query: 251 WNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 310
W + + H A V+++ + + + + D+ ++ W T + L +
Sbjct: 88 WVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTA---SDDKTVKVWATHRQKFLFSLSQH 144
Query: 311 SQVCNLA-WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 369
A +S +VS + +W S V H V Y+ P G I
Sbjct: 145 INWVRCAKFSPDGRLIVSAS--DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 370 VTGAGDETLRFWNV 383
D T++ W+V
Sbjct: 203 AAAGMDNTVKVWDV 216
Score = 43.1 bits (100), Expect = 4e-04
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 4/114 (3%)
Query: 140 GDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSS 197
G VT V + G +A V++WD + L + H+A V L++ + L +
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 198 GSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
S D + D+ L L GH+ + +S + ASGG+D +++VW
Sbjct: 247 ASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 37.7 bits (86), Expect = 0.019
Identities = 18/61 (29%), Positives = 30/61 (49%)
Query: 330 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 389
G + ++VW ++ + TGH V + SP G + +G+ D+T+R W K S
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 390 T 390
T
Sbjct: 97 T 97
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 70.5 bits (171), Expect = 3e-12
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 18/248 (7%)
Query: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSR 200
D+VT V +S G+L+A G+ V+IW + ++ HTA V ++ + ++ S
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS---- 117
Query: 201 DRMILQRDIRTPPLQSERR------LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 254
+ D +T + + R L H V K+S D +L+ S +D + +W+ S
Sbjct: 118 --FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 255 SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVC 314
S V Y EH V + + P + A+G D ++ W+ T + LQ S
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAG---MDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 315 N-LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 373
N L++ N L++ S +IL L + L GH +A S GE +G
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRL--LYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 374 GDETLRFW 381
DE + W
Sbjct: 291 SDEQVMVW 298
Score = 67.0 bits (162), Expect = 3e-11
Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 6/171 (3%)
Query: 217 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSP 276
ER +GHR V + +S + + LASG D+ L+VW+ S ++T H AV + +SP
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 277 HQHGLLASGGGTADRCIRFW-NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQ 335
H LLAS G+ D+ +R W + G+ + V ++ + V+
Sbjct: 72 SGH-LLAS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKT 126
Query: 336 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 386
+ VW + L+ H V SPDG IV+ + D+T++ W+ S+
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 53.1 bits (126), Expect = 4e-07
Identities = 44/194 (22%), Positives = 77/194 (39%), Gaps = 8/194 (4%)
Query: 191 NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLV 250
N +QL+SGS D ++ ++ P R GH+ V + +S LLASG D + +
Sbjct: 30 NTKQLASGSMDSCLMVWHMK--PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRI 87
Query: 251 WNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 310
W + + H A V+++ + + + + D+ ++ W T + L +
Sbjct: 88 WVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTA---SDDKTVKVWATHRQKFLFSLSQH 144
Query: 311 SQVCNLA-WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 369
A +S +VS + +W S V H V Y+ P G I
Sbjct: 145 INWVRCAKFSPDGRLIVSAS--DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 370 VTGAGDETLRFWNV 383
D T++ W+V
Sbjct: 203 AAAGMDNTVKVWDV 216
Score = 43.1 bits (100), Expect = 4e-04
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 4/114 (3%)
Query: 140 GDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSS 197
G VT V + G +A V++WD + L + H+A V L++ + L +
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 198 GSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 251
S D + D+ L L GH+ + +S + ASGG+D +++VW
Sbjct: 247 ASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 37.7 bits (86), Expect = 0.019
Identities = 18/61 (29%), Positives = 30/61 (49%)
Query: 330 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 389
G + ++VW ++ + TGH V + SP G + +G+ D+T+R W K S
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 390 T 390
T
Sbjct: 97 T 97
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 70.1 bits (170), Expect = 3e-12
Identities = 67/271 (24%), Positives = 120/271 (44%), Gaps = 17/271 (6%)
Query: 124 KKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTA 183
KK + ++RL + D+V +SE G +A +Q++ A G+KL ++ H
Sbjct: 600 KKNITNLSRLV-VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 658
Query: 184 RVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLAS 241
V A++ + +++ S D+ + + T L + C S+ H LLA+
Sbjct: 659 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 718
Query: 242 GGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG 301
G +D L +W+ + H +V +SP LLAS +AD ++ W+ +
Sbjct: 719 GSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK-LLASC--SADGTLKLWDATSA 775
Query: 302 QPLQCIDTGSQVCNLAWSKHANELV------STHGY-----SQNQILVWKYPSLTQVAKL 350
+ I+ NL + E++ S G ++N+I +W S ++VA
Sbjct: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADC 835
Query: 351 TGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 381
GH V + SPDG + +T + D+T+R W
Sbjct: 836 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 866
Score = 53.5 bits (127), Expect = 3e-07
Identities = 41/182 (22%), Positives = 80/182 (43%), Gaps = 6/182 (3%)
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
H V +S D Q +AS G D L V+ + + + H V A+S +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 283 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLA-WSKHANELVSTHGYSQNQILVWKY 341
+ D+ ++ WN++TG+ + D S+ N ++ ++ L+ G S + +W
Sbjct: 674 TC---SVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 342 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFT 401
+ GH+ V + SPD + + + + D TL+ W+ S + ++S++V F
Sbjct: 731 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS--ANERKSINVKQFFL 788
Query: 402 RI 403
+
Sbjct: 789 NL 790
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/164 (25%), Positives = 69/164 (42%), Gaps = 12/164 (7%)
Query: 223 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282
H++ V ++++ D + L S +D ++ VWN L H VK + L
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ-LDKCIFLRGHQETVKDFRLLKNSRLLS 1017
Query: 283 ASGGGTADRCIRFWNTLTG---QPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 339
S GT ++ WN +TG + C C++ S A + ST + +W
Sbjct: 1018 WSFDGT----VKVWNIITGNKEKDFVCHQGTVLSCDI--SHDATKFSSTS--ADKTAKIW 1069
Query: 340 KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
+ L + +L GH+ V A S D + TG + +R WNV
Sbjct: 1070 SFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV 1113
Score = 45.8 bits (107), Expect = 7e-05
Identities = 43/160 (26%), Positives = 74/160 (46%), Gaps = 21/160 (13%)
Query: 162 GFVQIWDAAAGKKLSMLEGHTARVGA--LAWNAEQLSSGSRDRM--ILQRDIRTPPLQSE 217
G V++W+ G K H V + ++ +A + SS S D+ I D+ P
Sbjct: 1022 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---- 1077
Query: 218 RRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS------LSPVQQ--YTEHLAAV 269
L+GH V +S D LLA+G ++ ++ +WN S+ +P+ + H V
Sbjct: 1078 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1137
Query: 270 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 309
+ +SP L+++GG I++WN +TG+ Q T
Sbjct: 1138 TDLCFSPDGKMLISAGG-----YIKWWNVVTGESSQTFYT 1172
Score = 37.0 bits (84), Expect = 0.032
Identities = 55/222 (24%), Positives = 85/222 (38%), Gaps = 46/222 (20%)
Query: 164 VQIWDAAAGKKLSMLEGH--TARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQ 221
+Q+W+ K + L GH T + L N+ +L S S D + +I T E+
Sbjct: 984 IQVWNWQLDKCI-FLRGHQETVKDFRLLKNS-RLLSWSFDGTVKVWNIITG--NKEKDFV 1039
Query: 222 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGL 281
H+ V S D +S D +W+ L P+ + H V+ A+S L
Sbjct: 1040 CHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-L 1098
Query: 282 LASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKY 341
LA+G + IR WN G+ L S+ E +THG W
Sbjct: 1099 LATGDDNGE--IRIWNVSNGELLHLCAPLSE-----------EGAATHGG-------W-- 1136
Query: 342 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 383
V L SPDG+ +++ G +++WNV
Sbjct: 1137 ---------------VTDLCFSPDGKMLISAGG--YIKWWNV 1161
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,214,131
Number of Sequences: 37866
Number of extensions: 747563
Number of successful extensions: 4244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 2189
Number of HSP's gapped (non-prelim): 1189
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.