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Search of human proteins with 208022653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 909 0.0
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 835 0.0
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 451 e-127
gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 301 1e-81
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 101 2e-21
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 97 4e-20
gi|4885259 myostatin [Homo sapiens] 94 2e-19
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 93 6e-19
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 89 8e-18
gi|4504699 inhibin beta A precursor [Homo sapiens] 88 1e-17
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 87 2e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 87 3e-17
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 87 3e-17
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 87 3e-17
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 87 3e-17
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 87 3e-17
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 84 2e-16
gi|13899338 activin beta E [Homo sapiens] 75 2e-13
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 73 6e-13
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 69 9e-12
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 69 1e-11
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 66 6e-11
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 66 6e-11
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 63 5e-10
gi|153792495 growth differentiation factor 15 [Homo sapiens] 62 1e-09
gi|239757187 PREDICTED: similar to growth differentiation factor... 62 1e-09
gi|110349792 growth differentiation factor 1 [Homo sapiens] 62 1e-09
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 60 4e-09
gi|222352098 nodal precursor [Homo sapiens] 55 1e-07
gi|7705308 growth differentiation factor 2 [Homo sapiens] 52 8e-07
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 909 bits (2350), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
Sbjct: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
Query: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV 120
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV
Sbjct: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV 120
Query: 121 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 180
VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
Sbjct: 121 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 180
Query: 181 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 240
RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
Sbjct: 181 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 240
Query: 241 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 300
HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
Sbjct: 241 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 300
Query: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
Sbjct: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
Query: 361 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 420
KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
Sbjct: 361 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 420
Query: 421 YIGKTPKIEQLSNMIVKSCKCS 442
YIGKTPKIEQLSNMIVKSCKCS
Sbjct: 421 YIGKTPKIEQLSNMIVKSCKCS 442
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 835 bits (2158), Expect = 0.0
Identities = 413/442 (93%), Positives = 414/442 (93%), Gaps = 28/442 (6%)
Query: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
Sbjct: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
Query: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV 120
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE
Sbjct: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE----- 115
Query: 121 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 180
+AIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
Sbjct: 116 -----------------------NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 152
Query: 181 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 240
RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
Sbjct: 153 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 212
Query: 241 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 300
HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
Sbjct: 213 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 272
Query: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
Sbjct: 273 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 332
Query: 361 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 420
KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
Sbjct: 333 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 392
Query: 421 YIGKTPKIEQLSNMIVKSCKCS 442
YIGKTPKIEQLSNMIVKSCKCS
Sbjct: 393 YIGKTPKIEQLSNMIVKSCKCS 414
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 451 bits (1161), Expect = e-127
Identities = 232/441 (52%), Positives = 295/441 (66%), Gaps = 41/441 (9%)
Query: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65
L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP
Sbjct: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
Query: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE---TVCPVVT 122
+V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM VCP
Sbjct: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
Query: 123 TPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRL 182
T ++ RF+VS++EKN +NL +AEFRV R+
Sbjct: 128 TS-------------------------------KVFRFNVSSVEKNRTNLFRAEFRVLRV 156
Query: 183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHK 242
NP ++ EQRIEL+QIL+ D QRYI K + TR EWLSFDVTD V EWL +
Sbjct: 157 PNPSSKRNEQRIELFQILR-PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRR 215
Query: 243 DRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKN 302
+ NLG +IS+HCPC TF P N I+ N E +E +F G+D + GD +K K+
Sbjct: 216 ESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK---KQK 271
Query: 303 SGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK 361
PHL+LM++P +RL++ Q +RKKRALD YCFRN+++NCC+RPLYIDF++DLGWK
Sbjct: 272 DHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK 331
Query: 362 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY 421
W+HEPKGY ANFC+G CPYL S+DT HS VL LYNT+NPEASASPCCV QDLEPLTILYY
Sbjct: 332 WVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391
Query: 422 IGKTPKIEQLSNMIVKSCKCS 442
+G+TPK+EQLSNM+VKSCKCS
Sbjct: 392 VGRTPKVEQLSNMVVKSCKCS 412
>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
Length = 390
Score = 301 bits (770), Expect = 1e-81
Identities = 183/429 (42%), Positives = 245/429 (57%), Gaps = 69/429 (16%)
Query: 18 ALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPP-EDYPEPEEVPPEVISIYNSTRD 76
A LSTC T+DM+ RKRIEAIRGQILSKL+L SPP + P +P V+++YNSTRD
Sbjct: 27 AAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRD 86
Query: 77 LLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQS 136
+ + +A E E + +YYAKEV ++ M ET + S S+
Sbjct: 87 ----RVAGESAEPEPE-PEADYYAKEVTRVLMV-----ETHNEIYDKFKQSTHSI----- 131
Query: 137 QVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASN---LVKAEFRVFRLQNPKARVPEQR 193
+ F+ S + + L +AE R+ RL K +V EQ
Sbjct: 132 --------------------YMFFNTSELREAVPEPVLLSRAELRLLRL---KLKV-EQH 167
Query: 194 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 253
+ELYQ ++ + RY+ ++++ EWLSFDVT V +WL GF++S H
Sbjct: 168 VELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAH 222
Query: 254 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLML 313
C C ++ L+ I+G +T GD TI + P LLLM
Sbjct: 223 CSC-----------DSRDNTLQV---DINGFTTGRRGDLATIHGMNR------PFLLLMA 262
Query: 314 LPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANF 373
P R + Q++R + RALD YCF + + NCC+R LYIDF++DLGWKWIHEPKGY+ANF
Sbjct: 263 TPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF 321
Query: 374 CAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSN 433
C G CPY+WS DTQ+S+VL+LYN NP ASA+PCCV Q LEPL I+YY+G+ PK+EQLSN
Sbjct: 322 CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSN 381
Query: 434 MIVKSCKCS 442
MIV+SCKCS
Sbjct: 382 MIVRSCKCS 390
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 101 bits (251), Expect = 2e-21
Identities = 84/304 (27%), Positives = 141/304 (46%), Gaps = 31/304 (10%)
Query: 150 FYRPYF--RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQ--RIELYQILKSKDL 205
F+ P + R RFD+S + + + + AEFR+++ + R + RI +YQ+L+
Sbjct: 146 FFHPRYHHREFRFDLSKIPEGEA-VTAAEFRIYK-DYIRERFDNETFRISVYQVLQEHLG 203
Query: 206 TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFV-PSNN 264
+DS+ + EG WL FD+T + W+ + NLG ++S+ + P
Sbjct: 204 RESDLFLLDSRTLWASEEG-WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLA 262
Query: 265 YIIPNKSEELEARF--AGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ 322
+I + + F A T + + T R +N KTP L + E+
Sbjct: 263 GLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENS 322
Query: 323 QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 381
+++R+ C LY+ F RDLGW+ WI P+GY A +C G C +
Sbjct: 323 SSDQRQA---------------CKKHELYVSF-RDLGWQDWIIAPEGYAAYYCEGECAFP 366
Query: 382 WSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVK 437
+S T H+ V +L + INPE PCC L +++LY+ + I ++ NM+V+
Sbjct: 367 LNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVR 426
Query: 438 SCKC 441
+C C
Sbjct: 427 ACGC 430
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 96.7 bits (239), Expect = 4e-20
Identities = 101/426 (23%), Positives = 154/426 (36%), Gaps = 112/426 (26%)
Query: 36 RIEAIRGQILSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAA 88
R+E+I+ QILSKL+L P E + PP +++ +++ D LQ
Sbjct: 75 RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP-------- 126
Query: 89 CERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPP 148
E ++EY+A I M ++ P V T LC + P
Sbjct: 127 -EDFLEEDEYHATTETVISM-----AQETDPAVQTDGSP-----------LCCHFHFSPK 169
Query: 149 TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP 208
+ + ++KA+ V+ VP QIL+ K LT
Sbjct: 170 VMF------------------TKVLKAQLWVYLRP-----VPRPATVYLQILRLKPLTGE 206
Query: 209 T--------QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCC 257
+R+I + +K G W S D +H W N G +I+ P
Sbjct: 207 GTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDP-- 264
Query: 258 TFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSY 317
SG + S G P + L +L
Sbjct: 265 -------------------------------SGTDLAVTSLGPGAEGLHPFMELRVL--- 290
Query: 318 RLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGA 377
+ +R +R L + + CC PL +DF+ GW WI PK Y AN+C+G
Sbjct: 291 -----ENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQ 344
Query: 378 CPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIV 436
C Y++ H+ L NP SA PCC + P+ +LY+ K I ++ M+V
Sbjct: 345 CEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVV 401
Query: 437 KSCKCS 442
C CS
Sbjct: 402 DRCGCS 407
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 94.4 bits (233), Expect = 2e-19
Identities = 98/412 (23%), Positives = 162/412 (39%), Gaps = 93/412 (22%)
Query: 36 RIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSD 95
RIEAI+ QILSKL+L + P ++V +++ R+L+ + +R + + D
Sbjct: 52 RIEAIKIQILSKLRLETAPNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108
Query: 96 EEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYF 155
++Y+A T ++T P+ S D + +P
Sbjct: 109 DDYHA---------------TTETIITMPTES----------------DFLMQVDGKPKC 137
Query: 156 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKS-KDLTSPTQRYID 214
+F S ++ N +VKA+ ++ P +++ +++K KD T RY
Sbjct: 138 CFFKFS-SKIQYN--KVVKAQLWIYL--RPVETPTTVFVQILRLIKPMKDGT----RYTG 188
Query: 215 SKVVK---TRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKS 271
+ +K G W S DV + WL + NLG +I +
Sbjct: 189 IRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKA--------------LDENG 234
Query: 272 EELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRA 331
+L F G G P L ++ T +R +R
Sbjct: 235 HDLAVTFPG-------------------PGEDGLNPFL--------EVKVTDTPKRSRRD 267
Query: 332 LDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRV 391
+ + CC PL +DF+ GW WI PK Y AN+C+G C +++ H+
Sbjct: 268 FGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH- 325
Query: 392 LSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKCS 442
L + NP SA PCC + P+ +LY+ GK I ++ M+V C CS
Sbjct: 326 --LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 92.8 bits (229), Expect = 6e-19
Identities = 69/270 (25%), Positives = 118/270 (43%), Gaps = 53/270 (19%)
Query: 194 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 253
I +YQ+L+ +D++VV EG WL FD+T + W+ N+G ++S
Sbjct: 274 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMGLQLS-- 330
Query: 254 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNS 303
++ + R AG+ G + + +++TR +S
Sbjct: 331 ------------VVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASS 378
Query: 304 GKTPHLLLMLLPSYRLESQQTNRRKKRALDAA-------YCFRNVQDNCCLRPLYIDFKR 356
+ QQ+ R ++ D A Y ++ C LY+ F+
Sbjct: 379 RRR---------------QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQ- 422
Query: 357 DLGWK-WIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQD 412
DLGW+ WI PKGY AN+C G C + ++ T H+ V +L + +NPE PCC
Sbjct: 423 DLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTK 482
Query: 413 LEPLTILYYIGKTPKI-EQLSNMIVKSCKC 441
L +++LY+ + I ++ NM+V++C C
Sbjct: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 89.0 bits (219), Expect = 8e-18
Identities = 77/283 (27%), Positives = 125/283 (44%), Gaps = 45/283 (15%)
Query: 172 LVKAEFRVFRLQNPKARVPEQ----RIELYQILKSKDLTS--PTQRYIDSKVVKTRAEGE 225
+ AE +VFR Q A RI +Y+I+K S P R +D+++V A
Sbjct: 145 ITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-R 203
Query: 226 WLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCTFVPSNNYIIPNKSEELEARFAGIDGT 284
W SFDVT AV W N GF + + H V + I + E ++ I
Sbjct: 204 WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPL 263
Query: 285 STYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDN 344
D K P ++ E +Q ++++ L + +
Sbjct: 264 LVTFGHDGKGH-------------------PLHKREKRQAKHKQRKRL---------KSS 295
Query: 345 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS---SDTQHSRVLSLYNTINP 400
C PLY+DF D+GW WI P GY+A +C G CP+ + + T H+ V +L N++N
Sbjct: 296 CKRHPLYVDFS-DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS 354
Query: 401 EASASPCCVSQDLEPLTILYYIGKTPKI--EQLSNMIVKSCKC 441
+ + CCV +L +++L Y+ + K+ + +M+V+ C C
Sbjct: 355 KIPKA-CCVPTELSAISML-YLDENEKVVLKNYQDMVVEGCGC 395
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 88.2 bits (217), Expect = 1e-17
Identities = 84/312 (26%), Positives = 139/312 (44%), Gaps = 44/312 (14%)
Query: 156 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQR--IELYQILKSKDLTSPT---- 209
+ + F++S + S + +AE +F L+ PKA + I L+Q K + T
Sbjct: 134 KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEA 192
Query: 210 ----------QRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTF 259
+ + KVV R + W F V+ ++ L +L +I+ C C
Sbjct: 193 EEVGLKGERSELLLSEKVVDAR-KSTWHVFPVSSSIQRLLDQGKSSLDVRIA--CEQCQE 249
Query: 260 VPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRL 319
++ ++ K ++ E +G G + + +K P L+L R
Sbjct: 250 SGASLVLLGKKKKKEE------EGEGKKKGGGEGGAGADEEKEQSHRPFLMLQA----RQ 299
Query: 320 ESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 378
+RR++R L+ C V + CC + ++ FK D+GW WI P GY+AN+C G C
Sbjct: 300 SEDHPHRRRRRGLE---CDGKV-NICCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGEC 354
Query: 379 P-----YLWSSDTQHSRVLSLYNT--INPEASASPCCVSQDLEPLTILYY-IGKTPKIEQ 430
P SS + HS V++ Y +P A+ CCV L P+++LYY G+ +
Sbjct: 355 PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKD 414
Query: 431 LSNMIVKSCKCS 442
+ NMIV+ C CS
Sbjct: 415 IQNMIVEECGCS 426
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/306 (23%), Positives = 130/306 (42%), Gaps = 42/306 (13%)
Query: 152 RPYFRIVRFDVSAMEKNASNLVKAEFRVFR-LQNPKARVPEQRIELYQILKSKDLTSPTQ 210
R +++ RFD++ + + + AEFR+++ N + +I +YQI+K
Sbjct: 174 RRHYKEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADL 232
Query: 211 RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNK 270
+D++ + G WL FD+T + W+ + NLG ++
Sbjct: 233 FLLDTRKAQALDVG-WLVFDITVTSNHWVINPQNNLGLQLCAET--------------GD 277
Query: 271 SEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLE 320
+ + AG+ G + + ++S R N K + +
Sbjct: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQN-------RNKSS 330
Query: 321 SQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP 379
S Q + R D Y + C LY+ F RDLGW+ WI P+GY A +C G C
Sbjct: 331 SHQDSSRMSSVGD--YNTSEQKQACKKHELYVSF-RDLGWQDWIIAPEGYAAFYCDGECS 387
Query: 380 YLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMI 435
+ ++ T H+ V +L + + P+ PCC L +++LY+ + I ++ NM+
Sbjct: 388 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV 447
Query: 436 VKSCKC 441
V+SC C
Sbjct: 448 VRSCGC 453
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 87.0 bits (214), Expect = 3e-17
Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 43/313 (13%)
Query: 142 YLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQ 198
+L+ IP T FR + F++S++ +N + AE R+FR Q P RI +Y+
Sbjct: 125 HLENIPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 199 ILKSKDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HC 254
++K P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHL 241
Query: 255 PCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLL 314
+ I + +A + D + TR++ + ++P
Sbjct: 242 HQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP------- 294
Query: 315 PSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANF 373
+ SQ+ ++ K NC LY+DF D+GW WI P GY A +
Sbjct: 295 ---KHHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFY 336
Query: 374 CAGACPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-- 428
C G CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+
Sbjct: 337 CHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVL 394
Query: 429 EQLSNMIVKSCKC 441
+ M+V+ C C
Sbjct: 395 KNYQEMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 87.0 bits (214), Expect = 3e-17
Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 43/313 (13%)
Query: 142 YLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQ 198
+L+ IP T FR + F++S++ +N + AE R+FR Q P RI +Y+
Sbjct: 125 HLENIPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 199 ILKSKDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HC 254
++K P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHL 241
Query: 255 PCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLL 314
+ I + +A + D + TR++ + ++P
Sbjct: 242 HQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP------- 294
Query: 315 PSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANF 373
+ SQ+ ++ K NC LY+DF D+GW WI P GY A +
Sbjct: 295 ---KHHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFY 336
Query: 374 CAGACPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-- 428
C G CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+
Sbjct: 337 CHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVL 394
Query: 429 EQLSNMIVKSCKC 441
+ M+V+ C C
Sbjct: 395 KNYQEMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 87.0 bits (214), Expect = 3e-17
Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 43/313 (13%)
Query: 142 YLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQ 198
+L+ IP T FR + F++S++ +N + AE R+FR Q P RI +Y+
Sbjct: 125 HLENIPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 199 ILKSKDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HC 254
++K P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHL 241
Query: 255 PCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLL 314
+ I + +A + D + TR++ + ++P
Sbjct: 242 HQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP------- 294
Query: 315 PSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANF 373
+ SQ+ ++ K NC LY+DF D+GW WI P GY A +
Sbjct: 295 ---KHHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFY 336
Query: 374 CAGACPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-- 428
C G CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+
Sbjct: 337 CHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVL 394
Query: 429 EQLSNMIVKSCKC 441
+ M+V+ C C
Sbjct: 395 KNYQEMVVEGCGC 407
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 87.0 bits (214), Expect = 3e-17
Identities = 75/298 (25%), Positives = 130/298 (43%), Gaps = 28/298 (9%)
Query: 153 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 212
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
Query: 213 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 272
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
Query: 273 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 328
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
Query: 329 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 384
D + Q C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 287 G-IFDDVHGSHGRQV-CRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
Query: 385 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 441
T H+ + SL + + P+A CC L ++LYY I + NM+VK+C C
Sbjct: 344 ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 87.0 bits (214), Expect = 3e-17
Identities = 74/298 (24%), Positives = 129/298 (43%), Gaps = 28/298 (9%)
Query: 153 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 212
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
Query: 213 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 272
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
Query: 273 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 328
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
Query: 329 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 384
D + + C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 287 GIFDDVRGS--HGRQVCRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
Query: 385 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 441
T H+ + SL + + P A CC L ++LYY I + NM+VK+C C
Sbjct: 344 ATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 84.3 bits (207), Expect = 2e-16
Identities = 80/302 (26%), Positives = 135/302 (44%), Gaps = 50/302 (16%)
Query: 172 LVKAEFRVFRLQNPKARV---PEQRIELYQILKSKDLTSPTQRY---IDSKVVKTRAEGE 225
++ AE R++ L + +++I ++++L+SK + + ++ T +E
Sbjct: 140 VIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSE-- 197
Query: 226 WLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG---ID 282
W +FDVTDA+ W K + ++ +H I +K +E E +G ID
Sbjct: 198 WETFDVTDAIRRW--QKSGSSTHQLEVH-------------IESKHDEAEDASSGRLEID 242
Query: 283 GTSTYT--------SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALD- 333
++ S DQ + K +++ + H L L + L+S + ++ L
Sbjct: 243 TSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQM 302
Query: 334 --------AAYCFRNVQDNCCLR-PLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWS 383
A RN + N C R PLYIDFK ++GW WI P GY A C G C Y +
Sbjct: 303 RSNIIYDSTARIRRNAKGNYCKRTPLYIDFK-EIGWDSWIIAPPGYEAYECRGVCNYPLA 361
Query: 384 ---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVKSC 439
+ T+H+ + +L + N + ++ CCV LEP++ILY G + M V C
Sbjct: 362 EHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSEC 421
Query: 440 KC 441
C
Sbjct: 422 GC 423
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 74.7 bits (182), Expect = 2e-13
Identities = 42/106 (39%), Positives = 64/106 (60%), Gaps = 10/106 (9%)
Query: 345 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC-PYLWSSD----TQHSRVLSLYNTI 398
CC R Y+DF+ +LGW+ WI +P+GY N+C+G C P+L S + HS V SL
Sbjct: 247 CCRRDHYVDFQ-ELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKAN 305
Query: 399 NPEASASPCCVSQDLEPLTILY--YIGKTPKIEQLSNMIVKSCKCS 442
NP +++ CCV PL++LY + G K + + +M+V++C CS
Sbjct: 306 NPWPASTSCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 72.8 bits (177), Expect = 6e-13
Identities = 80/315 (25%), Positives = 125/315 (39%), Gaps = 41/315 (13%)
Query: 160 FDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVK 219
FDVS++ +A +V AE RV R +P++ +L + + R + S+ +
Sbjct: 143 FDVSSLN-DADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAE 201
Query: 220 TRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFA 279
W +FDV DA+ F + L VPS P L +
Sbjct: 202 PLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGP-VPS-----PLALRRLGFGWP 255
Query: 280 GIDGTSTYTSGDQKTIKSTRKKNS-----GKTPHLLLMLLPSYRLESQQTN--------- 325
G G++ T++K S L L S L T
Sbjct: 256 GGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIG 315
Query: 326 --RRKKRALDAAYCF------------RNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYN 370
RR++ AL R + C +PL++DFK +LGW WI P Y
Sbjct: 316 GRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFK-ELGWDDWIIAPLDYE 374
Query: 371 ANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPK 427
A C G C + S T H+ + +L N++ P+A+ + CCV L P++ILY
Sbjct: 375 AYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNV 434
Query: 428 I-EQLSNMIVKSCKC 441
+ +Q +M+V++C C
Sbjct: 435 VYKQYEDMVVEACGC 449
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 68.9 bits (167), Expect = 9e-12
Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 9/124 (7%)
Query: 326 RRKKRALDAAYCFRNVQDN---CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 381
RR++ A + + R+ + + C +PL+++FK +LGW WI P Y A C G C +
Sbjct: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFK-ELGWDDWIIAPLEYEAYHCEGVCDFP 390
Query: 382 WSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVK 437
S T H+ + +L N+++P ++ CCV L P++ILY G +Q +M+V+
Sbjct: 391 LRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVE 450
Query: 438 SCKC 441
SC C
Sbjct: 451 SCGC 454
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 68.6 bits (166), Expect = 1e-11
Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 10/127 (7%)
Query: 324 TNRRKKRALDAAYC----FRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 378
+ RRK+RA A +N++ C + L+++FK D+GW WI P Y A C G C
Sbjct: 375 SQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLC 433
Query: 379 PYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNM 434
+ S T H+ + +L N+++PE++ CCV L P++IL+ + +Q +M
Sbjct: 434 EFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
Query: 435 IVKSCKC 441
+V+SC C
Sbjct: 494 VVESCGC 500
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 66.2 bits (160), Expect = 6e-11
Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 133 SRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRV-FRLQNPKARVPE 191
SR L G+L +R + D++ + + A EF + F + + ++P+
Sbjct: 173 SRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKE--NEEFLIGFNITSKGRQLPK 230
Query: 192 QRI---ELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGF 248
+R+ E Y ++ + D + S + R +F T V +W H L
Sbjct: 231 RRLPFPEPYILVYANDAAISEPESVVSSLQGHR------NFP-TGTVPKWDSHIRAALSI 283
Query: 249 KISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPH 308
+ +P N +P + + + T Q KS KK K PH
Sbjct: 284 ERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPH 343
Query: 309 LLLMLLPSYRLESQQTNR-RKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEP 366
L + + Q + R+K+ ++ NC R L +DF D+GW +WI P
Sbjct: 344 RKSQTL---QFDEQTLKKARRKQWIEPR--------NCARRYLKVDFA-DIGWSEWIISP 391
Query: 367 KGYNANFCAGACPYLWSSD---TQHSRVLSLYNTIN-PEASASPCCVSQDLEPLTILYY- 421
K ++A +C+GAC + + H+ + S+ + PCCV + + L+IL++
Sbjct: 392 KSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFD 451
Query: 422 IGKTPKIEQLSNMIVKSCKC 441
K ++ NM V+SC C
Sbjct: 452 ENKNVVLKVYPNMTVESCAC 471
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 66.2 bits (160), Expect = 6e-11
Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 345 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS-----SDTQHSRVLSLY--N 396
CC + ++DF R++GW WI +P+GY NFC G CP + + + H+ VL+L N
Sbjct: 247 CCRQEFFVDF-REIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN 305
Query: 397 TINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS 442
T CCV PL++LYY + ++ + +M+V++C CS
Sbjct: 306 TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 63.2 bits (152), Expect = 5e-10
Identities = 37/107 (34%), Positives = 62/107 (57%), Gaps = 11/107 (10%)
Query: 345 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP-YL----WSSDTQHSRVLSLYNT- 397
CC + +IDF R +GW WI P GY N+C G+CP YL S+ + H+ V++ Y
Sbjct: 303 CCRQQFFIDF-RLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361
Query: 398 -INPEASASPCCVSQDLEPLTILYYIGKTPKIEQ-LSNMIVKSCKCS 442
+NP + + CC+ L +++LY+ + +++ + NMIV+ C C+
Sbjct: 362 GLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 172 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 225
Query: 361 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 419
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 226 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 285
Query: 420 YYIGKTPKIEQLSNMIVKSCKC 441
++ +++ K C C
Sbjct: 286 QKTDTGVSLQTYDDLLAKDCHC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 134 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 187
Query: 361 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 419
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 188 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 247
Query: 420 YYIGKTPKIEQLSNMIVKSCKC 441
++ +++ K C C
Sbjct: 248 QKTDTGVSLQTYDDLLAKDCHC 269
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 61.6 bits (148), Expect = 1e-09
Identities = 34/106 (32%), Positives = 55/106 (51%), Gaps = 10/106 (9%)
Query: 345 CCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGAC--PYLWSSD-----TQHSRVLSLYN 396
C R LY+ F R++GW +W+ P+G+ AN+C G C P S H+ + +L +
Sbjct: 267 CRARRLYVSF-REVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
Query: 397 TINPEASASPCCVSQDLEPLTILYYIGK-TPKIEQLSNMIVKSCKC 441
P A+ PCCV L P+++L++ + Q +M+V C C
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 60.1 bits (144), Expect = 4e-09
Identities = 38/128 (29%), Positives = 65/128 (50%), Gaps = 7/128 (5%)
Query: 319 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGA 377
L Q + +KR + ++ C L+I+F RDLGW KWI PKG+ AN+C G
Sbjct: 238 LNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINF-RDLGWHKWIIAPKGFMANYCHGE 296
Query: 378 CPY---LWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSN 433
CP+ + + + ++ + +L + ++PE + C+ L P+++LY I +
Sbjct: 297 CPFSLTISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPISMLYQDNNDNVILRHYED 355
Query: 434 MIVKSCKC 441
M+V C C
Sbjct: 356 MVVDECGC 363
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 352 IDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPC 407
+DF +GW WI PK YNA C G CP + T H+ + SL P S C
Sbjct: 254 VDFNL-IGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTC 312
Query: 408 CVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKC 441
C +PL++LY ++ +MIV+ C C
Sbjct: 313 CAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGC 346
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 52.4 bits (124), Expect = 8e-07
Identities = 63/276 (22%), Positives = 113/276 (40%), Gaps = 45/276 (16%)
Query: 194 IELYQILKSKDL---TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHH---KDRN-L 246
+ +Y +L D + T+ ++ S+ ++ W + +V+ AV W+ K +N L
Sbjct: 170 VVIYDVLDGTDAWDSATETKTFLVSQDIQDEG---WETLEVSSAVKRWVRSDSTKSKNKL 226
Query: 247 GFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKT 306
+ H C + + +P S L + ++ ++SG ++T R+ S +
Sbjct: 227 EVTVESHRKGCDTLDIS---VPPGSRNLPFF---VVFSNDHSSGTKETRLELREMISHEQ 280
Query: 307 PHLLLMLLPSYRLESQQTNR---------------RKKRALDAAYCFRNVQDNCCLRPLY 351
+L L E+ +++ R+KR+ A +C L
Sbjct: 281 ESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAG-------SHCQKTSLR 333
Query: 352 IDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPC 407
++F+ D+GW WI PK Y A C G C + + D T+H+ V +L + P C
Sbjct: 334 VNFE-DIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKAC 392
Query: 408 CVSQDLEPLTILYY--IGKTPKIEQLSNMIVKSCKC 441
CV L P+++LY +G M V C C
Sbjct: 393 CVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,561,035
Number of Sequences: 37866
Number of extensions: 798223
Number of successful extensions: 2443
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2333
Number of HSP's gapped (non-prelim): 90
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.