Search of human proteins with 207113195

Search of human proteins with 207113195

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|207113195 erythrocyte membrane protein band 4.1-like 2
isoform b [Homo sapiens]
         (673 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...  1337   0.0  
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...  1337   0.0  
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...  1217   0.0  
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   582   e-166
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   582   e-166
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   578   e-165
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   536   e-152
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   536   e-152
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   512   e-145
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   310   2e-84
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   292   8e-79
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...   273   4e-73
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   273   4e-73
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   267   3e-71
gi|117500790 FERM domain containing 3 [Homo sapiens]                  254   1e-67
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   250   3e-66
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]         249   4e-66
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        246   4e-65
gi|34916000 FERM domain containing 7 [Homo sapiens]                   236   7e-62
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   225   1e-58
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   225   1e-58
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   160   4e-39
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...   150   3e-36
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...   150   3e-36
gi|4505257 moesin [Homo sapiens]                                      139   1e-32
gi|161702986 ezrin [Homo sapiens]                                     138   1e-32
gi|21614499 ezrin [Homo sapiens]                                      138   1e-32
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...   133   6e-31
gi|4506467 radixin [Homo sapiens]                                     131   2e-30
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                  128   1e-29

>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 1337 bits (3461), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
           MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60

Query: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
           RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120

Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
           EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180

Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
           QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240

Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
           QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300

Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
           PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360

Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
           FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420

Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
           LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480

Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
           AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540

Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
           RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600

Query: 601 KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV 660
           KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV
Sbjct: 601 KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV 660

Query: 661 VHKETELAEEGED 673
           VHKETELAEEGED
Sbjct: 661 VHKETELAEEGED 673


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 1337 bits (3461), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
           MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60

Query: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
           RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120

Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
           EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180

Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
           QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240

Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
           QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300

Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
           PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360

Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
           FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420

Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
           LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480

Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
           AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540

Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
           RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600

Query: 601 KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV 660
           KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV
Sbjct: 601 KAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVV 660

Query: 661 VHKETELAEEGED 673
           VHKETELAEEGED
Sbjct: 661 VHKETELAEEGED 673


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score = 1217 bits (3150), Expect = 0.0
 Identities = 611/611 (100%), Positives = 611/611 (100%)

Query: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
           MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1   MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60

Query: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
           RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61  RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120

Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
           EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180

Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
           QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240

Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
           QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300

Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
           PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360

Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
           FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420

Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
           LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480

Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
           AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540

Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
           RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600

Query: 601 KAPHLQLIEGK 611
           KAPHLQLIEGK
Sbjct: 601 KAPHLQLIEGK 611



 Score =  126 bits (316), Expect = 7e-29
 Identities = 63/63 (100%), Positives = 63/63 (100%)

Query: 611  KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
            KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE
Sbjct: 943  KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002

Query: 671  GED 673
            GED
Sbjct: 1003 GED 1005


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  582 bits (1499), Expect = e-166
 Identities = 286/440 (65%), Positives = 353/440 (80%), Gaps = 5/440 (1%)

Query: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREE 175
           E  P+++ + +  A    +    +    KEE+    ++   + +       E+  KE+E 
Sbjct: 10  ESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEF 69

Query: 176 KVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLE 235
             +  ++  LE    + +    +++  K  ++  K+ KK K++QCKV LLDG+EY+CD+E
Sbjct: 70  AARAAKQ--LEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVE 127

Query: 236 KHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVK 295
           K ++GQVLFDKVCEHLNLLEKDYFGL ++++  QKNWLDPAKEIK+Q+R+  W F+FNVK
Sbjct: 128 KRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVK 187

Query: 296 FYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGS 355
           FYPPDP+QL+EDITRY+LCLQLR DI SGRLPCSFVT ALLGSYT+Q+ELGDYDP+E GS
Sbjct: 188 FYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS 247

Query: 356 IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
             +SEF+FAP  TKELE+KV ELHK+HRG++PA+A+  FLENAK+LSMYGVDLHHAKDSE
Sbjct: 248 DYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSE 307

Query: 416 GVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKL 475
           GV+I LGVCA+GLLIY+DRLRINRFAWPK+LKISYKR+NFYIK+RP E EQFESTIGFKL
Sbjct: 308 GVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKL 367

Query: 476 PNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRP 535
           PNHRAAKRLWKVCVEHHTF+RL+ PE PPK KFLTLGSKFRYSGRTQAQTR+AS LIDRP
Sbjct: 368 PNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRP 426

Query: 536 APHFERTSSKR--VSRSLDG 553
           AP+FER+SSKR  +SRSLDG
Sbjct: 427 APYFERSSSKRYTMSRSLDG 446



 Score =  115 bits (287), Expect = 2e-25
 Identities = 74/148 (50%), Positives = 88/148 (59%), Gaps = 15/148 (10%)

Query: 537  PHFERTSSKRVSRSLDG-APIGVMDQSLMKDFPGAAGEISAY---------GPGLVSIAV 586
            PHFE ++ K  + S    +P GV  +   K+ P    E             G  L    +
Sbjct: 944  PHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVL 1003

Query: 587  VQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIRE 646
            +       E  S T   H+     KTVKGGISETRIEKRIVITGD DIDHDQALAQAI+E
Sbjct: 1004 MSAQTITSETTSTTTTTHIT----KTVKGGISETRIEKRIVITGDADIDHDQALAQAIKE 1059

Query: 647  AREQHPDMSVTRVVVHKETELA-EEGED 673
            A+EQHPDMSVT+VVVHKETE+  E+GED
Sbjct: 1060 AKEQHPDMSVTKVVVHKETEITPEDGED 1087


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  582 bits (1499), Expect = e-166
 Identities = 295/460 (64%), Positives = 350/460 (76%), Gaps = 25/460 (5%)

Query: 156 PSVSKVEMQPTELVSKEREEKVKETQEDKLEG-GAAKRETKEVQTNELKAEKASQKVTKK 214
           P  +  E  P++  ++  E+ +   ++D  E  G ++R T        KA+K+ QK+ KK
Sbjct: 40  PEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPS------KAQKSPQKIAKK 93

Query: 215 TKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
            K+  C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKDYFGL F ++  QKNWLD
Sbjct: 94  YKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153

Query: 275 PAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
           P+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQLR DI +GRLPCSFVTHA
Sbjct: 154 PSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHA 213

Query: 335 LLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQF 394
           LLGSY +QAELGDYD EEH    +SE +FAP QT+ELEE++ ELHKT+RG++P +A+  F
Sbjct: 214 LLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHF 273

Query: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
           LENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRINRFAWPKILKISYKRSN
Sbjct: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333

Query: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSK 514
           FYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RLVSPE PPK  FL +GSK
Sbjct: 334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSK 392

Query: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAPIGVMDQSLMKDFPGAAG 572
           FRYSGRTQAQTRQAS LIDRPAP FER+SSKR  +SRSLDGA             P +  
Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEF---------SRPASVS 443

Query: 573 EISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQ 606
           E    GP         +  G+R      EVR+PTK   L+
Sbjct: 444 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELK 483



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)

Query: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
           A EI +  P +    +        E  S +   H+     KTVKGG SETRIEKRI+ITG
Sbjct: 777 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 832

Query: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
           D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E  D
Sbjct: 833 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 875



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)

Query: 1   MTTEVGSVSEVKKDS----SQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQ 56
           MTTE G  SEVKK       Q    A    P   A +   +++  E+    Q    AE  
Sbjct: 1   MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60

Query: 57  SSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEE 116
             +     EK+ SE+ G+S    P  K QKS   +        K+   A+    +LD  E
Sbjct: 61  LDM----EEKDYSEADGLSERTTP-SKAQKSPQKIA-------KKYKSAICRVTLLDASE 108

Query: 117 PLPEEQRQAKG 127
              E ++  +G
Sbjct: 109 YECEVEKHGRG 119


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  578 bits (1491), Expect = e-165
 Identities = 287/420 (68%), Positives = 334/420 (79%), Gaps = 18/420 (4%)

Query: 198 QTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKD 257
           +T   KA+K+ QK+ KK K+  C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKD
Sbjct: 15  RTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKD 74

Query: 258 YFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQL 317
           YFGL F ++  QKNWLDP+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQL
Sbjct: 75  YFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQL 134

Query: 318 RQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAE 377
           R DI +GRLPCSFVTHALLGSY +QAELGDYD EEH    +SE +FAP QT+ELEE++ E
Sbjct: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194

Query: 378 LHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRI 437
           LHKT+RG++P +A+  FLENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRI
Sbjct: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254

Query: 438 NRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL 497
           NRFAWPKILKISYKRSNFYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RL
Sbjct: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314

Query: 498 VSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAP 555
           VSPE PPK  FL +GSKFRYSGRTQAQTRQAS LIDRPAP FER+SSKR  +SRSLDGA 
Sbjct: 315 VSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE 373

Query: 556 IGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQLIE 609
                       P +  E    GP         +  G+R      EVR+PTK   L+ ++
Sbjct: 374 F---------SRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLD 424



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)

Query: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
           A EI +  P +    +        E  S +   H+     KTVKGG SETRIEKRI+ITG
Sbjct: 675 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 730

Query: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
           D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E  D
Sbjct: 731 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 773


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  536 bits (1380), Expect = e-152
 Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)

Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
           + CKV+LLD T Y C +EKHAKGQ L  +VCEHLNLLE+DYFGL   ++   K WLD AK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
           EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
           SYT+Q+ELGDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
           AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
           K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300

Query: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
           SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+  
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356

Query: 578 GPGLVSIAVVQDGDGRREV 596
             G V+   V D   ++ V
Sbjct: 357 -QGQVAEGGVLDASAKKTV 374



 Score =  107 bits (267), Expect = 4e-23
 Identities = 51/60 (85%), Positives = 57/60 (95%)

Query: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
           KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 582 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  536 bits (1380), Expect = e-152
 Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)

Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
           + CKV+LLD T Y C +EKHAKGQ L  +VCEHLNLLE+DYFGL   ++   K WLD AK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
           EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
           SYT+Q+ELGDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
           AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
           K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300

Query: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
           SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+  
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356

Query: 578 GPGLVSIAVVQDGDGRREV 596
             G V+   V D   ++ V
Sbjct: 357 -QGQVAEGGVLDASAKKTV 374



 Score =  110 bits (276), Expect = 3e-24
 Identities = 63/103 (61%), Positives = 71/103 (68%), Gaps = 10/103 (9%)

Query: 578 GPGLVSIAVVQDGDGRREVRS--PTKAPHLQLIEGKT--------VKGGISETRIEKRIV 627
           GP LV    V   D    V+S  PTK   +   E KT        VKGGISETRIEKRIV
Sbjct: 486 GPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIV 545

Query: 628 ITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
           ITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 546 ITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score =  512 bits (1319), Expect = e-145
 Identities = 296/611 (48%), Positives = 384/611 (62%), Gaps = 78/611 (12%)

Query: 1   MTTEVGSVSEVKKDSSQL---GTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQS 57
           MTTE   V+E +    Q    G +A     +E  + +  Q++   +    Q   A+   +
Sbjct: 1   MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60

Query: 58  SLRRQ--KREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKE 115
                  K ++ TSESRG+SR    +LK+ KS    V+++ G + E           DKE
Sbjct: 61  PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQ---VSEEEGKEVES----------DKE 107

Query: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKE---EKPSVSKVEMQPTELVSKE 172
           +    E  Q + +      ++  +K  +   +P +  +   +  S+S  E QP +     
Sbjct: 108 KG---EGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQ----- 159

Query: 173 REEKVKETQEDKLEGGAAKRETKEVQTNE----LKAE---KASQKVTKKTKTVQCKVTLL 225
             E+++E  + +++ G    E  +++  E     KAE   KASQK  +K + + CKV+LL
Sbjct: 160 --EELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLL 217

Query: 226 DGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRN 285
           D T Y C +E                                    WLD AKEIK+Q+R 
Sbjct: 218 DDTVYECVVE-----------------------------------TWLDSAKEIKKQVRG 242

Query: 286 LPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
           +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLGSYT+Q+EL
Sbjct: 243 VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302

Query: 346 GDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405
           GDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLENAK+LSMYG
Sbjct: 303 GDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYG 362

Query: 406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE 465
           VDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+IK+RP E E
Sbjct: 363 VDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 422

Query: 466 QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQT 525
           Q+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRYSGRTQAQT
Sbjct: 423 QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQT 482

Query: 526 RQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIA 585
           RQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+    G V+  
Sbjct: 483 RQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT---QGQVAEG 537

Query: 586 VVQDGDGRREV 596
            V D   ++ V
Sbjct: 538 GVLDASAKKTV 548



 Score =  107 bits (267), Expect = 4e-23
 Identities = 51/60 (85%), Positives = 57/60 (95%)

Query: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
           KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 716 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  310 bits (795), Expect = 2e-84
 Identities = 164/363 (45%), Positives = 232/363 (63%), Gaps = 12/363 (3%)

Query: 194 TKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNL 253
           T  V+ +EL  ++   +V        C + LLD T  +  + KH +GQVL D V +HL+L
Sbjct: 12  TYNVRASELARDRQHTEVV-------CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64

Query: 254 LEKDYFGL-LFQESPEQKNWLDPAKEIKRQL-RNLPWLFTFNVKFYPPDPSQLTEDITRY 311
            E+DYFGL L  +S +   WLDP K I++QL R  P+   F VKF+  DP++L E+ TRY
Sbjct: 65  TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRY 124

Query: 312 FLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL 371
              LQ++QDI +GRLPC   T ALL S+ +Q+ELGDYD  E+ S  LS++ F P Q ++ 
Sbjct: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184

Query: 372 EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431
           E+++A+LH+ H GLSPA+A+  +L  A+ L +YGV+ H+A+D    +I +GV + G+LIY
Sbjct: 185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIY 244

Query: 432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEH 491
           K+R+R+N F W KI+KIS+K   F+I++R    E  E+ +GF + N+RA K LWK CVEH
Sbjct: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304

Query: 492 HTFYRLVSPEQPPK---AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS 548
           HTF+RL  P  P K   A + TLGSKFRY GRT+ Q+ Q           F R+ SK ++
Sbjct: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA 364

Query: 549 RSL 551
           R L
Sbjct: 365 RKL 367


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  292 bits (747), Expect = 8e-79
 Identities = 153/337 (45%), Positives = 215/337 (63%), Gaps = 7/337 (2%)

Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
           + C+V+LLDGT+ S DL K AKGQ LFD++  HL+L+E DYFGL F +S +  +WLD  K
Sbjct: 43  ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTK 102

Query: 278 EIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALL 336
            IK+Q++   P+     VKFY  +P+ L E++TRY   LQL+QDI SG+L C F T   L
Sbjct: 103 SIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQL 162

Query: 337 GSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLE 396
            +Y LQAELGDYD  EH    +SEF+F P QT+E+E  + E  K +RG +PAQA++ +L 
Sbjct: 163 AAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLN 222

Query: 397 NAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFY 456
            AK L MYGVD+H  K  +G D  LG+   G+L+++   +I  F WPKI ++ +K++   
Sbjct: 223 KAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLT 282

Query: 457 IKV--RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPP--KAKFLTLG 512
           + V     + ++ E T  F+L + +A K LWK  VEHH F+RL  P Q    ++ F+ LG
Sbjct: 283 LVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLG 342

Query: 513 SKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSR 549
           S+FRYSG+T+ QT + +    R +  FER  SKR SR
Sbjct: 343 SRFRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYSR 377


>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score =  273 bits (698), Expect = 4e-73
 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)

Query: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
           T+ C+V LLDGTE S DL KHAKGQ LFD++  HL+L+E DYFGL F +S +  +WLD A
Sbjct: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143

Query: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
           K IK+Q++  P +   F VK+Y  +P+ L E+ TRY   LQLR DI SG+L C + T   
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203

Query: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
           L +  LQAELG+ +  EH    +SEF+F P QT+ +E  + +  K  RG SPAQA+  +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263

Query: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
             AK L MYGVD+H  +  +G +  LG+   G+LI++   +I  F WPKI K+ +K+S  
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323

Query: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
            + V   + +  + E T  F+L + R  K LWK  VEHH F+RL +P   +  ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383

Query: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
           GS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  273 bits (698), Expect = 4e-73
 Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)

Query: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
           T+ C+V LLDGTE S DL KHAKGQ LFD++  HL+L+E DYFGL F +S +  +WLD A
Sbjct: 84  TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143

Query: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
           K IK+Q++  P +   F VK+Y  +P+ L E+ TRY   LQLR DI SG+L C + T   
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203

Query: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
           L +  LQAELG+ +  EH    +SEF+F P QT+ +E  + +  K  RG SPAQA+  +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263

Query: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
             AK L MYGVD+H  +  +G +  LG+   G+LI++   +I  F WPKI K+ +K+S  
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323

Query: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
            + V   + +  + E T  F+L + R  K LWK  VEHH F+RL +P   +  ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383

Query: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
           GS+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score =  267 bits (682), Expect = 3e-71
 Identities = 149/350 (42%), Positives = 207/350 (59%), Gaps = 11/350 (3%)

Query: 212 TKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
           T   K V  K+ +LD T+ + ++ + A G+VL D VC HLNL+E DYFGL F +  +   
Sbjct: 34  TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV 93

Query: 272 WLDPAKEIKRQLRNLPWLFT-FNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
           WLD  K I +Q+R    +   F VKF+PPD +QL E++TRY   LQ++QD+A GRL C+ 
Sbjct: 94  WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCND 153

Query: 331 VTHALLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSP 387
            + ALL S+ +Q+E+GD+D     EH    L++ ++ P Q   LE+K+ E H  H G +P
Sbjct: 154 TSAALLISHIVQSEIGDFDEALDREH----LAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208

Query: 388 AQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILK 447
           A++D Q LE A+RL MYG+ LH AKD EG  I L V   G+L+++   +IN F W K+ K
Sbjct: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268

Query: 448 ISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKA 506
           +S+KR  F IK+RP     ++ T+ F + +    K  WK+CVEHH F+RL   P+  PK 
Sbjct: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328

Query: 507 KFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS-RSLDGAP 555
              + GS FR+SGRTQ Q              FER  SK  S RSL   P
Sbjct: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP 378


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score =  254 bits (650), Expect = 1e-67
 Identities = 135/352 (38%), Positives = 203/352 (57%), Gaps = 10/352 (2%)

Query: 208 SQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESP 267
           S  V   ++ ++C + LLD +E SC +++  KGQ L D +C + +LLEKDYFG+ + +  
Sbjct: 22  SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81

Query: 268 EQKNWLDPAKEIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRL 326
           +Q++WL+P K I +Q++ + P+   F VKFYP +P ++ E++TRY L LQ+++DI  GRL
Sbjct: 82  KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141

Query: 327 PCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGL 385
            CSF   A LG+  +QAELGDYDP+EH    +SEF+  P Q+++LE K+ E+HK   RG 
Sbjct: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201

Query: 386 SPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKI 445
           SP  A+   L  A  L  YGVD H  KDS G    LG  A G ++++   RI+   WP +
Sbjct: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261

Query: 446 LKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQ--- 502
            K+ ++   FY+       ++ ++ + F      A K LWK  VE+  FY+     Q   
Sbjct: 262 CKLKFEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKT 318

Query: 503 PPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERT--SSKRVSRSLD 552
              +K    GS+FRYSG+   +  +AS+ I R  P   R   +  R S SL+
Sbjct: 319 VSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  250 bits (639), Expect = 3e-66
 Identities = 145/358 (40%), Positives = 205/358 (57%), Gaps = 20/358 (5%)

Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
           K +  +V LLD T    D+E    GQVL  +V + LNL+E DYFG+ FQ +     WL+P
Sbjct: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101

Query: 276 AKEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
            K I RQ+R     +    VKF+PPDP QL E+ TRY   LQL++D+   RL C+  T A
Sbjct: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161

Query: 335 LLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQAD 391
           LL S+ LQ+E+GDYD     EH  ++    ++ P Q   LE K+ E H+ H G +PA++D
Sbjct: 162 LLTSHLLQSEIGDYDETLDREHLKVN----EYLPGQQHCLE-KILEFHQKHVGQTPAESD 216

Query: 392 SQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYK 451
            Q LE A++L MYG+  H A D EG  I+L V   G+L+++   +IN F W K+ K+S+K
Sbjct: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276

Query: 452 RSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKAKFLT 510
           R  F IK+ P     ++ T+ F L +    K  WK+CVE+HTF+RL+  P+   KA F +
Sbjct: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFS 336

Query: 511 LGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFP 568
            GS FRYSGRTQ Q      L+D    +F+ +  KR+      +      ++L  D P
Sbjct: 337 RGSSFRYSGRTQKQ------LVD----YFKDSGMKRIPYERRHSKTHTSVRALTADLP 384


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score =  249 bits (637), Expect = 4e-66
 Identities = 132/327 (40%), Positives = 192/327 (58%), Gaps = 7/327 (2%)

Query: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
           C V LLD +EY+C +++ AKGQ LFD +C HLNLLEKDYFG+ F +  +Q++WL+  K +
Sbjct: 19  CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78

Query: 280 KRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
            +QLR+ P +   F VKFYP DP+ L E+ITRY + LQ+++D+  GRL C     ALL +
Sbjct: 79  VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138

Query: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGLSPAQADSQFLEN 397
           Y LQAE+GDYD  +H     S+FQF P  +++LE K+AE+HKT   G +PA ++  FL  
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198

Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
           A+ L  YGVD H  KD  G    L     G ++ +   R++   W ++ K+ ++   FY+
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258

Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTL---GSK 514
            V  ++ E+ +  + +  P   A K LWK  +E+  FY+L    Q        L   GS+
Sbjct: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316

Query: 515 FRYSGRTQAQTRQASTLIDRPAPHFER 541
           FRYSGR   +  ++S  I R  P   R
Sbjct: 317 FRYSGRVAKEVMESSAKIKREPPEIHR 343


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  246 bits (629), Expect = 4e-65
 Identities = 135/340 (39%), Positives = 202/340 (59%), Gaps = 16/340 (4%)

Query: 220 CKVTLLDGTEYSCD-----LEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
           C+V LLD ++ +       ++K  KG V+ D V  H+NL+E DYFGL + +   Q  WLD
Sbjct: 13  CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLD 72

Query: 275 PAKEIK--RQLRNL--PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
           PAK +   ++L N   P+   F +KFY  DP +L E+ITRY   LQ++QD+  GRLPC  
Sbjct: 73  PAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPV 132

Query: 331 VTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQA 390
            T A LG+Y +Q+ELGDYDP +H +  +SE++F P Q +ELEE +  +HKT  G  P++A
Sbjct: 133 NTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEA 192

Query: 391 DSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISY 450
           +  +L  AK L MYGVDLH        +  LG+   G+++YK++ ++ ++ WP+I K+ +
Sbjct: 193 ELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHF 252

Query: 451 KRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE----QPPKA 506
           K + F ++V   +    E++  F+  +  A K LWK  VEHHTF+R+   E        +
Sbjct: 253 KETQFELRVLGKDCN--ETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLS 310

Query: 507 KFLTLGSKFRYSGRTQAQ-TRQASTLIDRPAPHFERTSSK 545
           KF ++  K RYSGRT  Q +R  S  + RP  +  R+ SK
Sbjct: 311 KFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSK 350


>gi|34916000 FERM domain containing 7 [Homo sapiens]
          Length = 714

 Score =  236 bits (601), Expect = 7e-62
 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)

Query: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
           KV  LD ++    +++ + G+ LF+  C HLNL EK+YFGL F        WL+  K I 
Sbjct: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64

Query: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339
           +Q++N   + F F VKF+P DP  L E++TRY   LQ+++D+A GRLPCS    AL+ S+
Sbjct: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124

Query: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399
            LQ+ELGD+  EE     L++ ++ P Q   LE K+   H+ H G SPA++D   L+ A+
Sbjct: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182

Query: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459
           +L MYG+  H A D EG+ I L V   G+L+ +   +IN F W KI K+S+KR +F IK+
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242

Query: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518
               L   + T+ F + +  A K  WK CVE+H F+RL   P+  PK    + GS FRYS
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302

Query: 519 GRTQAQ 524
           GRTQ Q
Sbjct: 303 GRTQRQ 308


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  225 bits (573), Expect = 1e-58
 Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)

Query: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256
           ++T+EL  EK   +V        C +  LDG   +  + K   GQVL D V  HL + EK
Sbjct: 15  IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67

Query: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314
           +YFGL   + S +   WL+ +K I++QL+   P    F V+F+ PDP+ L ++ TR+   
Sbjct: 68  EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127

Query: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374
           LQL+ DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   K
Sbjct: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187

Query: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434
           V  LH+ H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  
Sbjct: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247

Query: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494
           +  + + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF
Sbjct: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307

Query: 495 Y---RLVSPEQPPKAKFLTLGSK 514
           +   +L+  E+   +++ T+GS+
Sbjct: 308 FQAKKLLPQEKNVLSQYWTMGSR 330


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  225 bits (573), Expect = 1e-58
 Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)

Query: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256
           ++T+EL  EK   +V        C +  LDG   +  + K   GQVL D V  HL + EK
Sbjct: 15  IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67

Query: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314
           +YFGL   + S +   WL+ +K I++QL+   P    F V+F+ PDP+ L ++ TR+   
Sbjct: 68  EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127

Query: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374
           LQL+ DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   K
Sbjct: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187

Query: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434
           V  LH+ H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  
Sbjct: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247

Query: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494
           +  + + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF
Sbjct: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307

Query: 495 Y---RLVSPEQPPKAKFLTLGSK 514
           +   +L+  E+   +++ T+GS+
Sbjct: 308 FQAKKLLPQEKNVLSQYWTMGSR 330


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score =  160 bits (405), Expect = 4e-39
 Identities = 101/307 (32%), Positives = 154/307 (50%), Gaps = 18/307 (5%)

Query: 202 LKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGL 261
           LK ++  +        +  ++ LL+       L   + GQ   + V + L L E  YF L
Sbjct: 7   LKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSL 66

Query: 262 LFQESPEQKNWLDPAKEIKRQLRNL---PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLR 318
            +     Q+ W+D  K +K+QL      P ++ F V FY P  SQL ++ITRY   LQL+
Sbjct: 67  WYYNKQNQRRWVDLEKPLKKQLDKYALEPTVY-FGVVFYVPSVSQLQQEITRYQYYLQLK 125

Query: 319 QDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPT----QTKELEE- 373
           +DI  G +PC+      L    +QA+ GD+D  E     L +F   P       K LEE 
Sbjct: 126 KDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDF-LQKFALFPVGWLQDEKVLEEA 184

Query: 374 --KVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLI- 430
             KVA LH+ +RGL+   A+  +++  +R+  YG + + AKDS+G DI +G C  G+ + 
Sbjct: 185 TQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVK 244

Query: 431 YKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVE 490
           +K+      F W  I  +S+ +S F +     EL   E TI F+  +   AK +W++CV 
Sbjct: 245 HKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVA 299

Query: 491 HHTFYRL 497
            H FYRL
Sbjct: 300 RHKFYRL 306


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
           isoform 4 [Homo sapiens]
          Length = 737

 Score =  150 bits (380), Expect = 3e-36
 Identities = 72/198 (36%), Positives = 116/198 (58%), Gaps = 3/198 (1%)

Query: 320 DIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELH 379
           DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   KV  LH
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61

Query: 380 KTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR 439
           + H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  +  + 
Sbjct: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121

Query: 440 FAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY---R 496
           + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF+   +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181

Query: 497 LVSPEQPPKAKFLTLGSK 514
           L+  E+   +++ T+GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score =  150 bits (380), Expect = 3e-36
 Identities = 72/198 (36%), Positives = 116/198 (58%), Gaps = 3/198 (1%)

Query: 320 DIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELH 379
           DI  GRL C   +  +L SY +Q+  GDY+   H    LS+  F P Q ++   KV  LH
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61

Query: 380 KTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR 439
           + H GL  ++A+S ++  A+ L  YGV+LH  +D   +D+ +G+ + G+ +Y+  +  + 
Sbjct: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121

Query: 440 FAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY---R 496
           + W  ILKIS+KR  F+I  R  + E  E  + F + N+R+ K LWK CVEHHTF+   +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181

Query: 497 LVSPEQPPKAKFLTLGSK 514
           L+  E+   +++ T+GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  139 bits (349), Expect = 1e-32
 Identities = 95/294 (32%), Positives = 150/294 (51%), Gaps = 19/294 (6%)

Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
           KT+  +VT +D  E    ++ +  G+ LFD+V + + L E  +FGL +Q++     WL  
Sbjct: 3   KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61

Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
            K++  Q   +  P LF F  KFYP D S+ L +DIT+    LQ+++ I +  + C   T
Sbjct: 62  NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121

Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRG 384
             LL SY +Q++ GD++ E H S  L+  +  P +  E         EE++   H+ HRG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181

Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
           +    A  ++L+ A+ L MYGV+    K+ +G ++ LGV A GL IY+   R+     F 
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241

Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
           W +I  IS+    F IK    +   F     F  P  R  KR+  +C+ +H  Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 28/143 (19%), Positives = 69/143 (48%), Gaps = 8/143 (5%)

Query: 81  WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
           +++++K  T+ V      ++   QA  E+     E  + E +++ +  AE+  +K +  K
Sbjct: 291 YMRRRKPDTIEV------QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREK 344

Query: 141 VEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTN 200
            E+ E    + ++ K +  ++E Q    +  E+E K  +++ +KL     ++E +E +  
Sbjct: 345 EELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKL--AKERQEAEEAKEA 402

Query: 201 ELKAEKASQKVTKKTKTVQCKVT 223
            L+A +  +K  ++      ++T
Sbjct: 403 LLQASRDQKKTQEQLALEMAELT 425


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  138 bits (348), Expect = 1e-32
 Identities = 94/294 (31%), Positives = 148/294 (50%), Gaps = 19/294 (6%)

Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
           K +  +VT +D  E    ++ +  G+ LFD+V + + L E  YFGL + ++     WL  
Sbjct: 3   KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
            K++  Q   +  P  F F  KFYP D ++ L +DIT+    LQ+++ I S  + C   T
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
             LLGSY +QA+ GDY+ E H S  LS  +  P +          + E+++   H  HRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
           +    A  ++L+ A+ L MYG++    K+ +G D+ LGV A GL IY+   ++     F 
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
           W +I  IS+    F IK    +   F     F  P  R  KR+ ++C+ +H  Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)

Query: 21  DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
           + TK+  +E++E  Q      EE K +Q   A   ++      R KE  E + + +    
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410

Query: 81  WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
            +K Q+     +A+          A++EE    KE+ + E Q +AK   +++ + K+E+ 
Sbjct: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464

Query: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
           + +    P        VS   + S+     +PT   ++   E +++ + E+K    A K 
Sbjct: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524

Query: 193 ETKEVQTNELKAEKASQKVTKK 214
           E  + Q   L +E +  +   K
Sbjct: 525 ERVQRQLLTLSSELSQARDENK 546



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)

Query: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
           R+ K D  E+    Q++K + +EEK    K+ +    + E +  E V +E+E+ ++E +E
Sbjct: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346

Query: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
             L     + +TK+ +    +  + + ++ ++ K  Q +   L+    +      +LE+ 
Sbjct: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406

Query: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
           A  Q+   K  E L     +Y     L +E+  +K      W   AKE +  L       
Sbjct: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463

Query: 291 TFNVKFYPPDPSQLTEDIT 309
              +   PP P  + E ++
Sbjct: 464 HLVMTAPPPPPPPVYEPVS 482


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  138 bits (348), Expect = 1e-32
 Identities = 94/294 (31%), Positives = 148/294 (50%), Gaps = 19/294 (6%)

Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
           K +  +VT +D  E    ++ +  G+ LFD+V + + L E  YFGL + ++     WL  
Sbjct: 3   KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
            K++  Q   +  P  F F  KFYP D ++ L +DIT+    LQ+++ I S  + C   T
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
             LLGSY +QA+ GDY+ E H S  LS  +  P +          + E+++   H  HRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
           +    A  ++L+ A+ L MYG++    K+ +G D+ LGV A GL IY+   ++     F 
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
           W +I  IS+    F IK    +   F     F  P  R  KR+ ++C+ +H  Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)

Query: 21  DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
           + TK+  +E++E  Q      EE K +Q   A   ++      R KE  E + + +    
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410

Query: 81  WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
            +K Q+     +A+          A++EE    KE+ + E Q +AK   +++ + K+E+ 
Sbjct: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464

Query: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
           + +    P        VS   + S+     +PT   ++   E +++ + E+K    A K 
Sbjct: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524

Query: 193 ETKEVQTNELKAEKASQKVTKK 214
           E  + Q   L +E +  +   K
Sbjct: 525 ERVQRQLLTLSSELSQARDENK 546



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)

Query: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
           R+ K D  E+    Q++K + +EEK    K+ +    + E +  E V +E+E+ ++E +E
Sbjct: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346

Query: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
             L     + +TK+ +    +  + + ++ ++ K  Q +   L+    +      +LE+ 
Sbjct: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406

Query: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
           A  Q+   K  E L     +Y     L +E+  +K      W   AKE +  L       
Sbjct: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463

Query: 291 TFNVKFYPPDPSQLTEDIT 309
              +   PP P  + E ++
Sbjct: 464 HLVMTAPPPPPPPVYEPVS 482


>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
           [Homo sapiens]
          Length = 1187

 Score =  133 bits (334), Expect = 6e-31
 Identities = 89/290 (30%), Positives = 140/290 (48%), Gaps = 24/290 (8%)

Query: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
           ++ LLD     C L   + GQ   + V + L L E  YFGL F    +Q  W++  K +K
Sbjct: 24  RIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLK 83

Query: 281 RQL---RNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
           + L    N P LF F V FY P+ S L ++ TRY   LQ+++D+  GRL C+      L 
Sbjct: 84  KHLDKFANEPLLF-FGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLA 142

Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQT-------KELEEKVAELHKTHRGLSPAQA 390
              +QA+ GDY+  +     L E+   P          +EL +KVA+ HK H G+ PA+A
Sbjct: 143 GLAVQADFGDYNQFDSQDF-LREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEA 201

Query: 391 DSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR----FAWPKIL 446
           +  ++   +RL  +G ++   KD+ G  + LG+   G+ +   R RI R    + W  + 
Sbjct: 202 ELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV---RNRIGRQAVIYRWNDMG 258

Query: 447 KISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496
            I++ +S   +     EL   E T  F   +   AK + ++    H FY+
Sbjct: 259 NITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYK 303


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  131 bits (329), Expect = 2e-30
 Identities = 92/294 (31%), Positives = 149/294 (50%), Gaps = 19/294 (6%)

Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
           K +  +VT +D  E    ++ +  G+ LFD+V + + L E  +FGL + +S     WL  
Sbjct: 3   KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61

Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
            K++ +Q   +  P  F F  KF+P D S+ L ++IT+    LQ+++ I +  + C   T
Sbjct: 62  NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121

Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQ-------TKEL-EEKVAELHKTHRG 384
             LL SY +QA+ GDY+ E H    L+  +  P +       TKE  EE++   H+ HRG
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181

Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
           +    +  ++L+ A+ L MYGV+    K+ +G ++ LGV A GL IY+   ++     F 
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241

Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
           W +I  IS+    F IK    +   F     F  P  R  KR+  +C+ +H  Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 36/228 (15%)

Query: 8   VSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEE------EKGSQPPPAAESQSSLRR 61
           ++E +K+  +   +   E+ K++ E       + EE      E   +   A E    L +
Sbjct: 332 IAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEK 391

Query: 62  QKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEE 121
           ++R  E ++S  I++     +K Q+     +A+          A++EE    KEE   E 
Sbjct: 392 ERRAAEEAKS-AIAKQAADQMKNQEQLAAELAEFTAKI-----ALLEEAKKKKEEEATEW 445

Query: 122 QRQAKGDAEEMAQKKQEIKVEVKEEKPSV-------------SKEEKPSVSKVEMQPTEL 168
           Q +A    E++ + K+E+K  +    P                 +E  + +  E+    +
Sbjct: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505

Query: 169 VS-KEREEKVKETQEDK----------LEGGAAKRETKEVQTNELKAE 205
           ++ +  EE+V ETQ+++           E   A+ ETK+ Q + L AE
Sbjct: 506 MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAE 553



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 43/195 (22%), Positives = 82/195 (42%), Gaps = 22/195 (11%)

Query: 24  KEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLK 83
           + KP  + E QQ ++   EE+   Q   A       +R+  EKE              ++
Sbjct: 294 RRKPDTI-EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKER-----------IE 341

Query: 84  KQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEV 143
           ++K   +   K   ++    Q  +EEQ   K   L +E+++AK +AE + ++++      
Sbjct: 342 REKEELMERLKQIEEQTIKAQKELEEQT-RKALELDQERKRAKEEAERLEKERR----AA 396

Query: 144 KEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELK 203
           +E K +++K+    +   E    EL     +  + E  + K E      E  E Q     
Sbjct: 397 EEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKE-----EEATEWQHKAFA 451

Query: 204 AEKASQKVTKKTKTV 218
           A++  +K  ++ KTV
Sbjct: 452 AQEDLEKTKEELKTV 466



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 39/207 (18%), Positives = 79/207 (38%), Gaps = 15/207 (7%)

Query: 18  LGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRF 77
           L  D  +++ KE AE  + +    EE K +    AA+   +  +++   E +E       
Sbjct: 373 LELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKN--QEQLAAELAEFTAKIAL 430

Query: 78  IPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEE--QVLDKEEPLP----------EEQRQA 125
           +    KK++             +E  +   EE   V+    P P          E     
Sbjct: 431 LEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHD 490

Query: 126 KGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKL 185
           + +AE  A+   E  +  + E+  V++ +K    K ++Q       +  ++ K+TQ D L
Sbjct: 491 ENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVL 550

Query: 186 EGGAAKRETKEVQT-NELKAEKASQKV 211
                K    + +T  +++     Q++
Sbjct: 551 HAENVKAGRDKYKTLRQIRQGNTKQRI 577


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  128 bits (322), Expect = 1e-29
 Identities = 89/298 (29%), Positives = 150/298 (50%), Gaps = 22/298 (7%)

Query: 213 KKTKTVQCKVTLLDGT-EYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
           K+ KT   ++  +D   E++C+++   KG+ LFD VC  L L E  +FGL +    +   
Sbjct: 17  KQPKTFTVRIVTMDAEMEFNCEMKW--KGKDLFDLVCRTLGLRETWFFGLQYTIK-DTVA 73

Query: 272 WLDPAKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPC 328
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ+++ I   ++ C
Sbjct: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133

Query: 329 SFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHK 380
                 LL SY +QA+ GDYDP  H    L++ +  P +   L        EE++   + 
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193

Query: 381 THRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN-- 438
            HRG +  +A+ ++L+ A+ L MYGV+    ++ +G ++ LGV A GL IY    R+   
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253

Query: 439 -RFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
             F W +I  ISY    F IK    +++ F+    F     R  K + ++C+ +H  +
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,930,869
Number of Sequences: 37866
Number of extensions: 1341453
Number of successful extensions: 14444
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 930
Number of HSP's that attempted gapping in prelim test: 7066
Number of HSP's gapped (non-prelim): 4621
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.