Search of human proteins with 205360934

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205360934 fibronectin type III domain containing 3B [Homo
sapiens]
         (1204 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|205360934 fibronectin type III domain containing 3B [Homo sap...  2500   0.0  
gi|205360932 fibronectin type III domain containing 3B [Homo sap...  2500   0.0  
gi|118918395 fibronectin type III domain containing 3A isoform 1...  1202   0.0  
gi|118918397 fibronectin type III domain containing 3A isoform 2...  1153   0.0  
gi|110349719 titin isoform N2-A [Homo sapiens]                        162   2e-39
gi|110349717 titin isoform novex-2 [Homo sapiens]                     162   2e-39
gi|110349713 titin isoform novex-1 [Homo sapiens]                     162   2e-39
gi|110349715 titin isoform N2-B [Homo sapiens]                        162   2e-39
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   149   2e-35
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   148   3e-35
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   146   1e-34
gi|219842266 usherin isoform B [Homo sapiens]                         145   2e-34
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   145   2e-34
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   145   2e-34
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   135   3e-31
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   134   5e-31
gi|157311649 neogenin homolog 1 [Homo sapiens]                        129   1e-29
gi|119220552 sidekick 1 [Homo sapiens]                                128   3e-29
gi|222352127 sidekick 2 [Homo sapiens]                                117   9e-26
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   108   3e-23
gi|140560917 myomesin 1 isoform b [Homo sapiens]                      106   1e-22
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   105   3e-22
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...   100   1e-20
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]            96   2e-19
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    96   3e-19
gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]      95   4e-19
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...    95   4e-19
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...    95   4e-19
gi|140560919 myomesin 1 isoform a [Homo sapiens]                       95   4e-19
gi|83281200 protogenin [Homo sapiens]                                  95   5e-19

>gi|205360934 fibronectin type III domain containing 3B [Homo sapiens]
          Length = 1204

 Score = 2500 bits (6479), Expect = 0.0
 Identities = 1204/1204 (100%), Positives = 1204/1204 (100%)

Query: 1    MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC 60
            MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC
Sbjct: 1    MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC 60

Query: 61   IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120
            IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT
Sbjct: 61   IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120

Query: 121  HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180
            HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
Sbjct: 121  HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180

Query: 181  ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS 240
            ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS
Sbjct: 181  ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS 240

Query: 241  GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV 300
            GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV
Sbjct: 241  GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV 300

Query: 301  GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN 360
            GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN
Sbjct: 301  GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN 360

Query: 361  SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK 420
            SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK
Sbjct: 361  SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK 420

Query: 421  RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
            RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA
Sbjct: 421  RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480

Query: 481  PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR 540
            PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR
Sbjct: 481  PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR 540

Query: 541  STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
            STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG
Sbjct: 541  STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600

Query: 601  GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
            GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE
Sbjct: 601  GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660

Query: 661  SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV 720
            SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV
Sbjct: 661  SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV 720

Query: 721  YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD 780
            YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD
Sbjct: 721  YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD 780

Query: 781  GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF 840
            GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF
Sbjct: 781  GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF 840

Query: 841  NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI 900
            NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI
Sbjct: 841  NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI 900

Query: 901  LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960
            LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL
Sbjct: 901  LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
            PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL
Sbjct: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
            TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM
Sbjct: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080

Query: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
            KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG
Sbjct: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140

Query: 1141 AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY 1200
            AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY
Sbjct: 1141 AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY 1200

Query: 1201 FLMK 1204
            FLMK
Sbjct: 1201 FLMK 1204


>gi|205360932 fibronectin type III domain containing 3B [Homo sapiens]
          Length = 1204

 Score = 2500 bits (6479), Expect = 0.0
 Identities = 1204/1204 (100%), Positives = 1204/1204 (100%)

Query: 1    MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC 60
            MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC
Sbjct: 1    MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC 60

Query: 61   IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120
            IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT
Sbjct: 61   IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120

Query: 121  HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180
            HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
Sbjct: 121  HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180

Query: 181  ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS 240
            ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS
Sbjct: 181  ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS 240

Query: 241  GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV 300
            GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV
Sbjct: 241  GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV 300

Query: 301  GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN 360
            GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN
Sbjct: 301  GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN 360

Query: 361  SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK 420
            SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK
Sbjct: 361  SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK 420

Query: 421  RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
            RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA
Sbjct: 421  RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480

Query: 481  PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR 540
            PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR
Sbjct: 481  PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR 540

Query: 541  STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
            STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG
Sbjct: 541  STQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600

Query: 601  GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
            GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE
Sbjct: 601  GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660

Query: 661  SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV 720
            SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV
Sbjct: 661  SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV 720

Query: 721  YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD 780
            YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD
Sbjct: 721  YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD 780

Query: 781  GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF 840
            GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF
Sbjct: 781  GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF 840

Query: 841  NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI 900
            NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI
Sbjct: 841  NQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI 900

Query: 901  LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960
            LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL
Sbjct: 901  LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
            PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL
Sbjct: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
            TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM
Sbjct: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080

Query: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
            KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG
Sbjct: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140

Query: 1141 AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY 1200
            AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY
Sbjct: 1141 AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY 1200

Query: 1201 FLMK 1204
            FLMK
Sbjct: 1201 FLMK 1204


>gi|118918395 fibronectin type III domain containing 3A isoform 1
            [Homo sapiens]
          Length = 1198

 Score = 1202 bits (3111), Expect = 0.0
 Identities = 619/1206 (51%), Positives = 818/1206 (67%), Gaps = 29/1206 (2%)

Query: 13   LELPPLLNGEVAMMPH-LVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMS 71
            L+   +L+ +++++   +V+ D  QQVILVQVNPGE FTIR EDG  QCI GPA+VPMMS
Sbjct: 8    LDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMS 67

Query: 72   PNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHP 131
            PNGS+PPI+VPPGY  QVIED+ GVRRVVV PQ+PE +P S+       H   P     P
Sbjct: 68   PNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVP 126

Query: 132  HFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTYITREDQYSKPP 191
              +       Y PVTG GDM  Q+ PQ+     +YG+ +    +G S +  R+++ SK  
Sbjct: 127  TMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF--RDERSSKTY 183

Query: 192  H---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGGGSG---SGPGI 244
                KKLKDRQ  ++++++SPPSS  K  S    +NG  KG   G    GS    SG G 
Sbjct: 184  ERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGK 243

Query: 245  KKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSC 304
              T+          D++++E + E K  + +LS I KP  S+IQAR VVL+W+PP  L  
Sbjct: 244  GGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLIN 294

Query: 305  GPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362
            G     S P  Y YEV +S  G+DGKYK +Y GEE    L DL+PA DYH +V A YNS+
Sbjct: 295  GETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 354

Query: 363  KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRN 422
            KG+ SE   FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N++LEWDEGK N
Sbjct: 355  KGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGN 414

Query: 423  SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR 482
              F QC+ GSQK  K+TKL PAMG  FRL+ARND GTSG+S+EV+ YT G  P MP++P 
Sbjct: 415  GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV 474

Query: 483  LVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRST 542
            L +AGITW++LQWSKP G   +E I+Y LE++E+ +   F PKY GEDL  TVKNL+RST
Sbjct: 475  LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRST 534

Query: 543  QYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602
            +YKF++ A N+EGKS PSEV+  TT PD+PG P +P VKG + SH F + WDPPKDNGG+
Sbjct: 535  KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594

Query: 603  EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662
             I KY++E+ +G S  N+WE+ YSG+  E+    L PG  Y+LR  CIS GG S  SESL
Sbjct: 595  TINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653

Query: 663  PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE-DVASEVY 721
             V+T ++ PG C PPR+ GRPK KE+ L W  P  + G  +S YSVEM+  E D   EVY
Sbjct: 654  LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713

Query: 722  HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDG 781
             G E+ECTV +LLPG  Y FR+RA N  G+GP+S+  +ITTA GPP QCK P ++C    
Sbjct: 714  QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773

Query: 782  CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFN 841
            C  V WE P S+G D++EYRLEWG  E S+++ Y G    +EI+ L PA  Y CR+QA +
Sbjct: 774  CAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS 833

Query: 842  QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEIL 901
              GAGP+SE+V C TP S P  V+ L  + ++ ++    SPS CL ++WE+PC++GSEIL
Sbjct: 834  VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEIL 893

Query: 902  AYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960
            AY+ID GD  S+TVG  T +++ +L P+TTYRIRIQA+N +GAGPFS  IK KT+PLPP 
Sbjct: 894  AYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 953

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
            PPRLEC A   Q+LKLKWG+   KT + + I Y LQ+ED+N RF+S+YRGP HTYKVQRL
Sbjct: 954  PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRL 1013

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
             E T Y F IQA +EAGEGP S+ Y F+T KSVP  +KAP++ ++  + CEI WE +  M
Sbjct: 1014 NESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPM 1073

Query: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDT--SQEL 1138
            KGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R+C D+   Q+L
Sbjct: 1074 KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDL 1133

Query: 1139 SGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFIL 1198
             G +S +  F+ QR+E   + +  +++  + +  + +DEQ AA+I++ FA  SIL AFI+
Sbjct: 1134 VGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLFAFFSILIAFII 1192

Query: 1199 QYFLMK 1204
            QYF++K
Sbjct: 1193 QYFVIK 1198


>gi|118918397 fibronectin type III domain containing 3A isoform 2
            [Homo sapiens]
          Length = 1142

 Score = 1153 bits (2983), Expect = 0.0
 Identities = 593/1157 (51%), Positives = 783/1157 (67%), Gaps = 28/1157 (2%)

Query: 61   IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120
            + GPA+VPMMSPNGS+PPI+VPPGY  QVIED+ GVRRVVV PQ+PE +P S+       
Sbjct: 1    MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSP 59

Query: 121  HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180
            H   P     P  +       Y PVTG GDM  Q+ PQ+     +YG+ +    +G S +
Sbjct: 60   HPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF 118

Query: 181  ITREDQYSKPPH---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGG 236
              R+++ SK      KKLKDRQ  ++++++SPPSS  K  S    +NG  KG   G    
Sbjct: 119  --RDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINT 176

Query: 237  GSG---SGPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVV 293
            GS    SG G   T+          D++++E + E K  + +LS I KP  S+IQAR VV
Sbjct: 177  GSAKIKSGKGKGGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVV 227

Query: 294  LSWAPPVGLSCGPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
            L+W+PP  L  G     S P  Y YEV +S  G+DGKYK +Y GEE    L DL+PA DY
Sbjct: 228  LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287

Query: 352  HVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITN 411
            H +V A YNS+KG+ SE   FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N
Sbjct: 288  HAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQN 347

Query: 412  YLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTL 471
            ++LEWDEGK N  F QC+ GSQK  K+TKL PAMG  FRL+ARND GTSG+S+EV+ YT 
Sbjct: 348  FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTS 407

Query: 472  GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDL 531
            G  P MP++P L +AGITW++LQWSKP G   +E I+Y LE++E+ +   F PKY GEDL
Sbjct: 408  GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL 467

Query: 532  TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSV 591
              TVKNL+RST+YKF++ A N+EGKS PSEV+  TT PD+PG P +P VKG + SH F +
Sbjct: 468  AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKI 527

Query: 592  KWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
             WDPPKDNGG+ I KY++E+ +G S  N+WE+ YSG+  E+    L PG  Y+LR  CIS
Sbjct: 528  TWDPPKDNGGATINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCIS 586

Query: 652  TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             GG S  SESL V+T ++ PG C PPR+ GRPK KE+ L W  P  + G  +S YSVEM+
Sbjct: 587  DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 646

Query: 712  EPE-DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQC 770
              E D   EVY G E+ECTV +LLPG  Y FR+RA N  G+GP+S+  +ITTA GPP QC
Sbjct: 647  PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706

Query: 771  KAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPA 830
            K P ++C    C  V WE P S+G D++EYRLEWG  E S+++ Y G    +EI+ L PA
Sbjct: 707  KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPA 766

Query: 831  AQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW 890
              Y CR+QA +  GAGP+SE+V C TP S P  V+ L  + ++ ++    SPS CL ++W
Sbjct: 767  TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826

Query: 891  EEPCNNGSEILAYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
            E+PC++GSEILAY+ID GD  S+TVG  T +++ +L P+TTYRIRIQA+N +GAGPFS  
Sbjct: 827  EKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM 886

Query: 950  IKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
            IK KT+PLPP PPRLEC A   Q+LKLKWG+   KT + + I Y LQ+ED+N RF+S+YR
Sbjct: 887  IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR 946

Query: 1010 GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
            GP HTYKVQRL E T Y F IQA +EAGEGP S+ Y F+T KSVP  +KAP++ ++  + 
Sbjct: 947  GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006

Query: 1070 CEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACR 1129
            CEI WE +  MKGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R
Sbjct: 1007 CEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIR 1066

Query: 1130 RCLDT--SQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGF 1187
            +C D+   Q+L G +S +  F+ QR+E   + +  +++  + +  + +DEQ AA+I++ F
Sbjct: 1067 QCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLF 1125

Query: 1188 ATLSILFAFILQYFLMK 1204
            A  SIL AFI+QYF++K
Sbjct: 1126 AFFSILIAFIIQYFVIK 1142


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  162 bits (410), Expect = 2e-39
 Identities = 201/810 (24%), Positives = 324/810 (40%), Gaps = 96/810 (11%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P PP    +   +  S  L W  P D+G SKITNY++E          +        + K
Sbjct: 13784 PGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 13843

Query: 438   LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQ 494
              TKL P   Y FR+AA N  G  G   +    T       P  P RL  + IT   VTL 
Sbjct: 13844 ATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLT 13902

Query: 495   WSKPEGCSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
             W +P+      +  Y +E  + + D      K   +D T  VK L    +Y+FR+ A N 
Sbjct: 13903 WCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENL 13962

Query: 554   EGKSCPS---EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              G   PS   E ++     D P PP +P VK  V      + W  P+ +GG++I  Y++E
Sbjct: 13963 AGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIESYVIE 14021

Query: 611   ITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPV--RT 666
             +    ++  +W  VA     T++    L  G  Y  R   ++  G S+ SE S PV  R 
Sbjct: 14022 MLKTGTD--EWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCRE 14079

Query: 667   LSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP-- 724
                 P   R   V+   K+    L+W VP  + G  ++ Y VE  +      +       
Sbjct: 14080 KLYPPSPPRWLEVINITKNT-ADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVK 14138

Query: 725   ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDG 781
             + +CTV  L  G++Y FRV A N  G   Y+++ +   A      PG   A  +      
Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKR 14198

Query: 782   CVLVGWESPDSSGA-DISEYRLEWGEDEESLELIY------HGTDTRFEIRDLLPAAQYC 834
              V + WE P + G   I  Y +E    +E L   +       G D  F + D++   +  
Sbjct: 14199 HVDLKWEPPKNDGGRPIQRYVIE---KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQ 14255

Query: 835   CRLQAFNQAGAGPYSE---LVLCQTPASAPDPVSTLCVLEEEPLDAY-PDSPSACLVLNW 890
              +++A N+AG G  SE   ++  + P S P P          PLD +  D+    + + W
Sbjct: 14256 FQVRAENEAGVGHPSEPTEILSIEDPTSPPSP----------PLDLHVTDAGRKHIAIAW 14305

Query: 891   EEP-CNNGSEILAYTIDLGDT---------SITVGNTTMHVMKDLLPETTYRIRIQAINE 940
             + P  N GS I+ Y +++            S  + +    V + ++P+  Y +R++A+N 
Sbjct: 14306 KPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNA 14365

Query: 941   IGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH-----AAEDIVYTL 995
             IG    S+  +      P   P ++                  +TH       E +   +
Sbjct: 14366 IGVSEPSEISENVVAKDPDCKPTIDL-----------------ETHDIIVIEGEKLSIPV 14408

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLT---EFTCYSFRIQAASEAGEGPFS---ETYTFST 1049
                      +S ++         RLT   +       +  +  A  G ++   E    S 
Sbjct: 14409 PFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 14468

Query: 1050  TKSV-------PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQ 1101
             T S+       P   K  + + +  +SC++ WE      G P+ +Y+L+        Y  
Sbjct: 14469 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 14528

Query: 1102  VYKGE-EATFQISGLQTNTDYRFRVCACRR 1130
             V  GE + ++ +  L  N +Y FRV A  +
Sbjct: 14529 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 14558



 Score =  157 bits (396), Expect = 8e-38
 Identities = 220/917 (23%), Positives = 369/917 (40%), Gaps = 77/917 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D     +  +V  +   +V L+W PP+        G S   +Y V   +  R     
Sbjct: 21947 RVLDTPGPPQDLKVKEVTKTSVTLTWDPPL------LDGGSKIKNYIVEKRESTRKAYST 22000

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             +  +  +    +  L+    Y+ RV A      G  +E       S  P  P    L   
Sbjct: 22001 VATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDV 22060

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W+ P  D GS+I  Y++E  + K +  +  C         +T L     Y+F
Sbjct: 22061 TRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSF 22119

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT---LQWSKPEGCSPEEV 506
             R++A+N+ G S   Q  V     ++  +P A +L+    T +    L+   P    P   
Sbjct: 22120 RVSAQNEKGISDPRQLSVPVIAKDLV-IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPA 22178

Query: 507   ITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT 566
             +T+  +    +     + + T  +   T+K+  R     + +  +N+ G++  +  ++  
Sbjct: 22179 VTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVL 22238

Query: 567   TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
                D+PGPPT P+    VT+   ++ W PPK +GGS I  Y++E  D  +    W++  +
Sbjct: 22239 ---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRD--TSTTTWQIVSA 22293

Query: 627   GSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP-- 683
               A T      LK G  Y+ R    +  G S    S P    ++A    + P   G P  
Sbjct: 22294 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEP----TVAQYPFKVPGPPGTPVV 22349

Query: 684   ---KHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGT 737
                    + ++W+ P S+ G  V  Y +E  E   +     +    P+ +     L  G 
Sbjct: 22350 TLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGV 22409

Query: 738   VYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SS 793
              Y FRV A N  G G  S VSE   A     PPG+ +A  ++      V + W+ P    
Sbjct: 22410 EYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVT---RNSVTLQWKKPTYDG 22466

Query: 794   GADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRLQAFNQAG------ 844
             G+ I+ Y +E  E  E   +    T   DT FE+  L+   +Y  R+ A N AG      
Sbjct: 22467 GSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPS 22526

Query: 845   --AGPYSELVLCQTPASAPDP--VSTLCVLEEEPL----DAYPDSPSACLVLNWEEPCNN 896
                G  +       P  + DP    T+ V   E      D Y         +  ++  +N
Sbjct: 22527 ESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN 22586

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
              + +   + D   TS++V        KD +   +    ++A N  G    +  +K   RP
Sbjct: 22587 TARLEIKSTDFA-TSLSV--------KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY- 1015
              PP  P +  +    +   L W     +   ++ I Y ++  + ++   ++      T  
Sbjct: 22638 GPPEGP-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLS 22695

Query: 1016  -KVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
              KV +L E   Y+FRI A ++ G G    SE         VP   KAP VT +  +S  +
Sbjct: 22696 CKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIV 22755

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACR 1129
             +WE   S  G  +  Y+L+        + + +K    E   +++GL  N DY FRV A  
Sbjct: 22756 VWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA-- 22813

Query: 1130  RCLDTSQELSGAFSPSA 1146
                + +  LS    PSA
Sbjct: 22814 ---ENAAGLSEPSPPSA 22827



 Score =  156 bits (395), Expect = 1e-37
 Identities = 223/898 (24%), Positives = 352/898 (39%), Gaps = 90/898 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS++ A + VLSW  P         G +   +Y V   + G      +  S +  +  +
Sbjct: 28749 EVSSVSAESCVLSWGEP------KDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKV 28802

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L    +Y  RV +   +   K   S P+        P  P  P++ H S ++++++W+
Sbjct: 28803 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 28862

Query: 401   API-DNGSKITNYLLEWDEGKRNSGFRQ----CFFGSQKHCKLTKLCPAMGYTFRLAARN 455
              P  D GSKI  Y +E  E       ++    C    + + K+T L   + Y FR  A N
Sbjct: 28863 EPYHDGGSKIIGYWVEKKERNTILWVKENKVPCL---ECNYKVTGLVEGLEYQFRTYALN 28919

Query: 456   DIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE--- 512
               G S  S+        N    P  P +     + V+L WS P      +V+ Y +E   
Sbjct: 28920 AAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKP 28979

Query: 513   IQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPSEVLVCTTSPD 570
             + E  +       YT   D   TV  L     Y+FR+ A N  G  S  SE     T  D
Sbjct: 28980 VSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRD 29039

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKD------NGGSEILKYLLEITDGNSEANQWE-- 622
                PP   L       HG  V      D       GG    K +   T G+ E +  E  
Sbjct: 29040 EYAPPKAEL---DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIW--TKGDKELDLCEKV 29094

Query: 623   -VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
              + Y+G                K      +  G    + S+ V+ L  +PG C    V  
Sbjct: 29095 SLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTK--AVSVMVKVLD-SPGPCGKLTV-S 29150

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG--PELECTVGNLLPGTVY 739
             R   ++  L W +P  + G E++ Y VE  E   +   +  G  P L   V  L+    Y
Sbjct: 29151 RVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEY 29210

Query: 740   RFRVRALNDGGYGPYSDVSEIT-----TAAGPPGQCKAPCISCTPDGCVLVGWESPDSSG 794
              FRVRA+N  G G   +   I      T   PPG    P    T    +++ W  P+S G
Sbjct: 29211 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG---IPEEVGTGKEHIIIQWTKPESDG 29267

Query: 795   A-DISEYRLEWGEDEE----SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
               +IS Y ++  E +      +   Y   DTR ++  L+    Y  R+ A N AG    S
Sbjct: 29268 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 29327

Query: 850   E---LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTI 905
             E    + C+ P+  P P S   V+         D+    + L W +P  + G++I+ Y +
Sbjct: 29328 EASNFISCREPSYTPGPPSAPRVV---------DTTKHSISLAWTKPMYDGGTDIVGYVL 29378

Query: 906   DLGD----------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR 955
             ++ +          T+ T+ NT   V  DL     Y  R+ A+N  G   +S+ I A+  
Sbjct: 29379 EMQEKDTDQWYRVHTNATIRNTEFTV-PDLKMGQKYSFRVAAVNVKGMSEYSESI-AEIE 29436

Query: 956   PLPPLP-PRLECAAAGPQSLKLKWGDS-----NSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
             P+  +  P LE A    +++ ++ G S     +        I ++ Q  D   R I    
Sbjct: 29437 PVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTT 29496

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                    V ++  +    + I+A +++G+   +       T    P++K   V++   +S
Sbjct: 29497 ESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR---DS 29553

Query: 1070  CEILWETVPSMKGDPV-NYILQVLVGRESEYKQV-YKGEEATFQISGLQTNTDYRFRV 1125
               I WE      G PV NYI++        +K V  K  +  ++ISGL   T Y FRV
Sbjct: 29554 VTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 29611



 Score =  151 bits (382), Expect = 3e-36
 Identities = 213/899 (23%), Positives = 335/899 (37%), Gaps = 85/899 (9%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE--- 337
             +P+V ++ A A+ + W  P       H G S    Y V   ++       I++  E    
Sbjct: 28846 RPEVYHVSANAMSIRWEEPY------HDGGSKIIGYWVEKKERNT-----ILWVKENKVP 28894

Query: 338   -LECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSS 394
              LECN K   L    +Y  R YA+  +     SE           + P  P++   ++S+
Sbjct: 28895 CLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST 28954

Query: 395   LTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFR--QCFFG--SQKHCKLTKLCPAMGYTF 449
             ++L W AP  D GSK+  Y++E          R  +C +   S     +T L     Y F
Sbjct: 28955 VSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEF 29014

Query: 450   RLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPRL------VRAGITWVTLQWSKPE 499
             R+ A+N  G      E    V C      P+     RL      +RAG   V        
Sbjct: 29015 RVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVL---DAAV 29071

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             G  PE  I +T   +E +       +YTG+  T  +K   RS   K+ LT  N  G    
Sbjct: 29072 GGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAV 29131

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
             S ++    SP     P   L    VT    ++ W  P+++GG+EI  Y++E  +  S  N
Sbjct: 29132 SVMVKVLDSPG----PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRE-TSRLN 29186

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPP 677
                V        Y  T L     Y  R   ++  G     ES P+  R     P     P
Sbjct: 29187 WVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIP 29246

Query: 678   RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTVGNL 733
               +G  K + + ++W  P S+ G E+S Y V+  E + +     ++ Y   +    V +L
Sbjct: 29247 EEVGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSL 29305

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESP 790
             + G  Y+FRV A+N  G    S+ S   +   P   PG   AP +  T    + + W  P
Sbjct: 29306 MEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKP 29365

Query: 791   -DSSGADISEYRLEWGEDEESLELIYHGT----DTRFEIRDLLPAAQYCCRLQAFNQAGA 845
                 G DI  Y LE  E +       H      +T F + DL    +Y  R+ A N  G 
Sbjct: 29366 MYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGM 29425

Query: 846   GPYSELVLCQTPAS---------APDPVSTLCVLEEEPLDAYPD-SPSACLVLNWEEPCN 895
               YSE +    P           A D   T+ +     L      S     V+ W +   
Sbjct: 29426 SEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSK--- 29482

Query: 896   NGSEILAYTIDLGDTSI--TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                      IDL   +I  T  + ++ ++  +      +  I+A N+ G    +  +K  
Sbjct: 29483 -------QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVY 29535

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH 1013
               P P   P ++       S+ + W        A  +     + E   + F ++    S 
Sbjct: 29536 DTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK 29593

Query: 1014  T-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T Y++  L E T Y FR+   +  G G   ET        VP       V  +  ++  +
Sbjct: 29594 TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTL 29653

Query: 1073  LWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQ--ISGLQTNTDYRFRVCA 1127
              WE  P   G      Y+L+        + +V   +    +  ++ L     Y FR+ A
Sbjct: 29654 AWEK-PLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 29711



 Score =  151 bits (381), Expect = 4e-36
 Identities = 204/888 (22%), Positives = 355/888 (39%), Gaps = 68/888 (7%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P V+N+   ++ + W  PV       +G S    Y + + D+         K++      
Sbjct: 26676 PWVTNVTRESITVGWHEPVS------NGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHF 26729

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  +  +     Y  RVYA   +  G  S P        A E P   ++   SK+S++L 
Sbjct: 26730 K--VTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLS 26787

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W+ P  D GSKIT Y++E  +       +  F   ++    ++ L     Y FR+ ARN 
Sbjct: 26788 WQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNA 26847

Query: 457   IGTSGYSQEVV----CYTL--GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYT 510
             +G+     EVV    C     G +  +P     V       +++        P   I + 
Sbjct: 26848 VGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 26907

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
              + +E + + L   + T +  +  +K+  R     + L   N  G +  +   +     D
Sbjct: 26908 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT---IRVQILD 26964

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
             +PGPP  P+    VT+   ++ W PP D+GG++I  Y++E  +  S      V+      
Sbjct: 26965 KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRE-TSRVVWSMVSEHLEEC 27023

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQC--SESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
               T T +  G  Y  R   ++  G  +   S+S+  +   + PG    P V    K+  +
Sbjct: 27024 IITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKN-SM 27082

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPGTVYRFRV 743
              + W  P ++ G ++S Y +E  + +      V  E       + T   L   + Y++RV
Sbjct: 27083 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVT--GLTENSDYQYRV 27140

Query: 744   RALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISE 799
              A+N  G GP+S+ SE   AA    PPG      I+ +    + +GW  P    G+ ++ 
Sbjct: 27141 CAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTG 27200

Query: 800   YRLE--WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAGAG---PYSELV 852
             Y +E   GE+EE   +   G    T + + +L P   Y  R+ A N AG G     +E V
Sbjct: 27201 YVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPV 27260

Query: 853   LCQTPASAPD-------PVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
               +    AP+         S +    E+     P        + W +   N      Y+I
Sbjct: 27261 QAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSI 27320

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             +  D+S      ++  +  +    T +  +   N +G  P S  +  K    P    +L+
Sbjct: 27321 ENTDSS------SLLTIPQVTRNDTGKYILTIENGVGE-PKSSTVSVKVLDTPAACQKLQ 27373

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI--YRGPSHTYKVQRLTEF 1023
                    ++ L W D       +  I Y ++  D  KR  S+  ++  S ++K+  L+E 
Sbjct: 27374 VKHVSRGTVTLLW-DPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 27432

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             T + FR+ A +E G G   ET        VP  I+   +      S  + W T P   G 
Sbjct: 27433 TPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW-TKPDFDGG 27491

Query: 1084  PVNYILQVLVGRESEYKQVYK----GEEATFQISGLQTNTDYRFRVCA 1127
              V  I + +V R+ + +Q +      +    ++S L+  +   FRV A
Sbjct: 27492 SV--ITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFA 27537



 Score =  147 bits (372), Expect = 5e-35
 Identities = 194/806 (24%), Positives = 311/806 (38%), Gaps = 94/806 (11%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++S+TLQWK P  D GSKIT Y++E  E       +  F      
Sbjct: 22439 CDP--PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDT 22496

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPR-----LVR 485
             H ++T L     Y FR+ ARN  G      E    +      + P++   P+     +V 
Sbjct: 22497 HFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH 22556

Query: 486   AGITWV-----------TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG ++            T+QW K +              QE  N      K T    + +
Sbjct: 22557 AGESFKVDADIYGKPIPTIQWIKGD--------------QELSNTARLEIKSTDFATSLS 22602

Query: 535   VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD 594
             VK+  R     + L A N  G+     V V     DRPGPP  P+V   VT+   ++ W 
Sbjct: 22603 VKDAVRVDSGNYILKAKNVAGER---SVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWK 22659

Query: 595   PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT-EYTFTHLKPGTLYKLRACCISTG 653
             PP  +GGS+I+ Y++E  + +     W V  +   T     T L  G  Y  R   ++  
Sbjct: 22660 PPLQDGGSDIINYIVERRETSRLV--WTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKY 22717

Query: 654   GHSQCSESLPV--RTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV  +   + P   + P V    K   + + W+ PAS+ G E+  Y +E  
Sbjct: 22718 GVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI-VVWERPASDGGSEILGYVLEKR 22776

Query: 712   EPEDVASEVYHGP---ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP-- 766
             + E +     H     EL   V  L+    Y FRV A N  G    S  S    A  P  
Sbjct: 22777 DKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 22836

Query: 767   -PGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE---DEESLELIYHGTD-T 820
              PG    P +       V + W  P    G +I  Y +E  +    E ++     G + T
Sbjct: 22837 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 22896

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
               E+  LL   +Y  R+ A N+AG G ++++   ++ +    APD    L + +   + A
Sbjct: 22897 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRA 22956

Query: 878   -------YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT 930
                     P        + W +      +     +    TS+ + N   +          
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRY------DSGK 23010

Query: 931   YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSK 984
             Y + +    E  +G  S F+  +    P  P  L+       S+ + W      G S  K
Sbjct: 23011 YTLTL----ENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066

Query: 985   THAAEDIVYTLQLEDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              +  E      + E   K + ++      +++K+ +L E   Y FR+ A +E G G  ++
Sbjct: 23067 NYIVE------KREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 23120

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQ 1101
             T        VP       V  +  NS  + W T P   G    + YI+++      ++ +
Sbjct: 23121 TADPIKVAEVPQPPGKITVDDVTRNSVSLSW-TKPEHDGGSKIIQYIVEMQAKHSEKWSE 23179

Query: 1102  VYKGEEATFQISGLQTNTDYRFRVCA 1127
               + +     I+ L    +Y FRV A
Sbjct: 23180 CARVKSLQAVITNLTQGEEYLFRVVA 23205



 Score =  147 bits (372), Expect = 5e-35
 Identities = 204/794 (25%), Positives = 309/794 (38%), Gaps = 69/794 (8%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++++TL+WK P  D GSKIT Y++E  +       +  F    + 
Sbjct: 24603 CDP--PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLET 24660

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVR 485
                ++ L     Y FR+ ARN  G     S  S  +      + P     P+     +V 
Sbjct: 24661 EFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVH 24720

Query: 486   AGITWVT-----------LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG T+V            + WSK +G   EE     +EI           K T +  T  
Sbjct: 24721 AGETFVLEADIRGKPIPDVVWSK-DGKELEETAA-RMEI-----------KSTIQKTTLV 24767

Query: 535   VKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             VK+  R+   ++ L  SN  G KS P  V V     DRPGPP  PL    VT+    + W
Sbjct: 24768 VKDCIRTDGGQYILKLSNVGGTKSIPITVKVL----DRPGPPEGPLKVTGVTAEKCYLAW 24823

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTG 653
             +PP  +GG+ I  Y++E  +  S  +  +V+    A  Y  T L PG  Y  R   ++  
Sbjct: 24824 NPPLQDGGANISHYIIEKRE-TSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 24882

Query: 654   GHSQCSESLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV   +    PG    P V    K   V + W  P  + G E+  Y +E  
Sbjct: 24883 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMV-VTWARPVDDGGTEIEGYILEKR 24941

Query: 712   EPEDVASEVYHG---PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG--- 765
             + E V     +     +L   V  L  G  Y FRV A N  G G  S+ S    A     
Sbjct: 24942 DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALY 25001

Query: 766   PPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGE---DEESLELIYHGTD-T 820
             PPG    P ++ T    V + W  P    GA +  Y +E  E   DE +      G    
Sbjct: 25002 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGK 25061

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
             +F +  L    +Y  R+ A N  G G  + L   V+ Q     P+      + +   L A
Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121

Query: 878   YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQA 937
                      +    EP     +      D     +T  + TM V+ ++    + R  +  
Sbjct: 25122 SATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-SSFTMLVIDNVTRFDSGRYNLTL 25180

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQL 997
              N   +G  + F+  +    P  P  L        S+ L W        A        + 
Sbjct: 25181 EN--NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 25238

Query: 998   EDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT 1056
             E   K + +I       T++++ L E   Y FR+ A++E G G  +E  T    K   P 
Sbjct: 25239 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAE--TTEPVKVSEPP 25296

Query: 1057  IKAPRVTQLE--GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQIS 1113
             +   RVT ++   N+  I WE   S  G  +  Y++++      ++    + +     IS
Sbjct: 25297 LPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATIS 25356

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y FRV A
Sbjct: 25357 GLTAGEEYVFRVAA 25370



 Score =  146 bits (368), Expect = 1e-34
 Identities = 220/960 (22%), Positives = 387/960 (40%), Gaps = 137/960 (14%)

Query: 249   RRARSSPKSNDSDLQEYELEVKRVQD------ILSGIEKP------QVSNIQARAVVLSW 296
             R + +   +N +D  +Y L ++ V        ++  ++ P       V ++   + VLSW
Sbjct: 26239 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 26298

Query: 297   APPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVY 356
               P      P        +Y +   +  +     +  +   L   + +L+    Y+ RV 
Sbjct: 26299 DVPENDGGAPVK------NYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVS 26352

Query: 357   AMYN---SVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKI 409
                     +     E V  T      E P PP+   +   SK S++L W  P  D GS+I
Sbjct: 26353 GENEFGVGIPAETKEGVKIT------EKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRI 26406

Query: 410   TNYLLE-WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVC 468
              +Y++E  ++G++N  + +C      H  ++ L     Y FR+ A N  G S   + ++ 
Sbjct: 26407 VHYVVEALEKGQKN--WVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLP 26464

Query: 469   YTLG--------NIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
               +         ++   PS    VRAG     L+   P    P   +T + +    +   
Sbjct: 26465 VLIKEQLEPPEIDMKNFPSHTVYVRAGSN---LKVDIPISGKPLPKVTLSRDGVPLKATM 26521

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLV 580
              F+ + T E+LT  +K    +   ++ +TA+N+ G +   +  +     DRPGPPT P+V
Sbjct: 26522 RFNTEITAENLTINLKESVTADAGRYEITAANSSGTT---KAFINIVVLDRPGPPTGPVV 26578

Query: 581   KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPG 640
                +T    ++KW+PPK +GGS++  Y+L +    S A   EV+ + + T      L  G
Sbjct: 26579 ISDITEESVTLKWEPPKYDGGSQVTNYIL-LKRETSTAVWTEVSATVARTMMKVMKLTTG 26637

Query: 641   TLYKLRACCISTGGHSQCSES--LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
               Y+ R    +  G S   +S  + V+     PG    P V    + + + + W  P S 
Sbjct: 26638 EEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTR-ESITVGWHEPVSN 26696

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDGGYGPYS 755
              G  V  Y +EM +   +  +  +   +  T   V  +  G +Y FRV A N  G G  S
Sbjct: 26697 GGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 26756

Query: 756   DVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEY---RLEWGEDE 808
               SE      A  PP   +   IS      V + W+ P    G+ I+ Y   R +  +  
Sbjct: 26757 HPSEPVLAIDACEPPRNVRITDIS---KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGR 26813

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL- 867
              +     + T+T+F I  L   +QY  R+ A N  G+           P+    P++ + 
Sbjct: 26814 WTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGS--------ISNPSEVVGPITCID 26865

Query: 868   --------CVLEEEPLDAYPDSPSACL----------VLNW----EEPCNNGSEILAYTI 905
                       LE   +  Y    S  L           + W    +E   N    +  T 
Sbjct: 26866 SYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTT 26925

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             DL   SI + +       D L    Y ++++  N +G+   +  ++   +P PP  P +E
Sbjct: 26926 DL--ASILIKDA------DRLNSGCYELKLR--NAMGSASATIRVQILDKPGPPGGP-IE 26974

Query: 966   CAAAGPQSLKLKW----GDSNSK-TH------AAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
                   + + L W     D  +K TH          +V+++  E   +  I+       T
Sbjct: 26975 FKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIIT-------T 27027

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV----PPTIKAPRVTQLEGNSC 1070
              K+ +  E   Y FR++A ++ G G   E+ +     +     PP I  P VT++  NS 
Sbjct: 27028 TKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI--PEVTKITKNSM 27082

Query: 1071  EILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              ++W    +  G  ++ Y L+    +   + +V K    +   +++GL  N+DY++RVCA
Sbjct: 27083 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCA 27142



 Score =  145 bits (366), Expect = 2e-34
 Identities = 219/898 (24%), Positives = 343/898 (38%), Gaps = 89/898 (9%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             + P +SNI    + +SW PP      P +G         A++    + K  I     E  
Sbjct: 19492 DPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-----ERT 19546

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPEC----PFPPKLAHRSKSSL 395
                  L+  T+Y  RV A+  +  G  S+  S   ++  P+     P  PK+   ++SS+
Sbjct: 19547 LKATGLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFPKVYDTTRSSV 19605

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG---SQKHCKLTKLCPAMGYTFRL 451
             +L W  P  D GS I  YL+E      ++  R C       +   ++T L     Y FR+
Sbjct: 19606 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR-CNLPQNLQKTRFEVTGLMEDTQYQFRV 19664

Query: 452   AARNDIGTSG--------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
              A N IG S         Y ++++    G +        ++RAG   VT++   P    P
Sbjct: 19665 YAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG---VTMRLYVPVKGRP 19721

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVL 563
                IT++       +      K T  D     +N+ +    K+ LT  N+ GK    E  
Sbjct: 19722 PPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGK---KEYT 19778

Query: 564   VCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE- 622
             +     D PGPP    VK  ++     V W+PP  +GGS I+ Y+++  D  +E   W  
Sbjct: 19779 IVVKVLDTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRD--AERKSWST 19835

Query: 623   VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             V    S T +   +L+ G  Y  R    +  G     E+      S  PG     +V   
Sbjct: 19836 VTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSV 19895

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
              K     + W  P S+ G  +  Y V+    E+    V     L+ +  +L  G  Y FR
Sbjct: 19896 SK-SSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFR 19954

Query: 743   VRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS---E 799
             V A N+ G G     SEIT  A          +   PD C L    S       I     
Sbjct: 19955 VSAENENGEG---TPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPA 20011

Query: 800   YRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPAS 859
               + W + E+ L      TDTR  +     A      +    ++ AG Y+  +  +  A 
Sbjct: 20012 PSVSWKKGEDPL-----ATDTRVSVES--SAVNTTLIVYDCQKSDAGKYT--ITLKNVAG 20062

Query: 860   APDPVSTLCVLEEEPLDAYP----DSPSACLVLNWEEPCNN-GSEILAYTIDLGDT---- 910
               +   ++ V+ +  +   P    +  +  + L W  P ++ GSEI  Y ++  D+    
Sbjct: 20063 TKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNK 20122

Query: 911   ----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG---PFSQFIKAKTRPLPPLPPR 963
                 +  V  TT  V + L     Y  R+ A N+ G G        +      +P  PP 
Sbjct: 20123 WVTCASAVQKTTFRVTR-LHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPP 20181

Query: 964   LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT------YKV 1017
                      S+ L W D   KT  +    Y L+ ++RN     +++  + T      +KV
Sbjct: 20182 PNIVDVRHDSVSLTWTDP-KKTGGSPITGYHLEFKERNS---LLWKRANKTPIRMRDFKV 20237

Query: 1018  QRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWET 1076
               LTE   Y FR+ A + AG G P   +        + P  K P V  +  NS  ++W T
Sbjct: 20238 TGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK-PEVINITRNSVTLIW-T 20295

Query: 1077  VPSMKGDP--VNYILQVLVGRESEYKQVYKGE-----EATFQISGLQTNTDYRFRVCA 1127
              P   G      YI++    R+   K   K       E  F ++ L     Y FR+ A
Sbjct: 20296 EPKYDGGHKLTGYIVE---KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRA 20350



 Score =  145 bits (366), Expect = 2e-34
 Identities = 216/907 (23%), Positives = 353/907 (38%), Gaps = 111/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P+V +     ++++W  PV      + G S    Y +   ++         KI+ +  ++
Sbjct: 25593 PKVVHATKSTMLVTWQVPV------NDGGSRVIGYHLEYKERSSILWSKANKILIADTQM 25646

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCS---EPVSFTTHSCAPECPFPPKLAHRSKSSL 395
             +  +  L     Y  RVYA   +  G CS   EPV      C P  P  P++ + ++ S+
Sbjct: 25647 K--VSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDP--PGQPEVTNITRKSV 25701

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYTFRLAA 453
             +L+W  P  D G+KIT Y++E  E       +  +   Q+ + ++T+L     Y FR+ A
Sbjct: 25702 SLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFA 25761

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGITWVTLQWSKPEGCS 502
             RN   +     E     +      P  PR+           V+AG     L+ +      
Sbjct: 25762 RNAADSVSEPSESTGPIIVKDDVEP--PRVMMDVKFRDVIVVKAG---EVLKINADIAGR 25816

Query: 503   PEEVITYT---LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             P  VI++    +EI+E     +     T      TVK+  R    ++ LT  N  G    
Sbjct: 25817 PLPVISWAKDGIEIEERARTEIIS---TDNHTLLTVKDCIRRDTGQYVLTLKNVAGTR-- 25871

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V V     D+PGPP  PL    +T+   S+ W  P+++GG++I  Y++E  + +  A 
Sbjct: 25872 -SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLA- 25929

Query: 620   QWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
              W +       T    T L  G  Y  R   ++  G  +  ES+ ++ L        P  
Sbjct: 25930 -WTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTS 25988

Query: 679   VLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDV------ASEVYHGPELECTVG 731
             +      KE + L W  P S+ G E+S Y +E  E   +         VY   +L     
Sbjct: 25989 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVY---DLRVKST 26045

Query: 732   NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWE 788
              L  G  Y +RV A N  G    S+ S +  A  P   P     P I  +    + + W 
Sbjct: 26046 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWV 26105

Query: 789   SP-DSSGADISEYRLEW--GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGA 845
              P    GA I+ Y +E+   +D +    I     T + I  L   A+Y  R+++ N+ GA
Sbjct: 26106 KPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 26165

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN---------------- 889
                        P+ + DP       EEEPL          L++                 
Sbjct: 26166 ---------SDPSDSSDP-QIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPV 26215

Query: 890   ----WEEPCNNGSEILAYTIDLGD--TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
                 W +P +      AY +D  D  TS+T+ N   +          Y + IQ  N + A
Sbjct: 26216 PNVLWSKP-DTDLRTRAY-VDTTDSRTSLTIENANRN------DSGKYTLTIQ--NVLSA 26265

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
                +  +K    P P  P  +       +S  L W    +   A     +  + E   K 
Sbjct: 26266 ASLTLVVKVLDTPGP--PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKA 26323

Query: 1004  FISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRV 1062
             ++S+    +  +YKV  L E   Y FR+   +E G G  +ET         P   +   V
Sbjct: 26324 WVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGV 26383

Query: 1063  TQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             T +  +S  + W   P   G    V+Y+++ L   +  + +    +     +SGL+ N++
Sbjct: 26384 TSISKDSVSLTW-LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSE 26442

Query: 1121  YRFRVCA 1127
             Y FRV A
Sbjct: 26443 YFFRVFA 26449



 Score =  145 bits (365), Expect = 3e-34
 Identities = 217/907 (23%), Positives = 339/907 (37%), Gaps = 109/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG------ 335
             P  + I   ++V+ W  PV     P  G    Y  E       R  +  I+++       
Sbjct: 23429 PFATAISKDSMVIQWHEPVNNGGSPVIG----YHLE-------RKERNSILWTKVNKTII 23477

Query: 336   EELECNLKDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
              + +   ++L    +Y  RVYA  +    K S +         C P  P  P+     ++
Sbjct: 23478 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRN 23535

Query: 394   SLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRL 451
              +TLQW  P+ D GS IT Y++E  +       +  F    +    ++ L     Y FR+
Sbjct: 23536 EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 23595

Query: 452   AARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITWVTLQWSKPEGCS 502
              A+N  G     S  +  +       +P++   P+     +V AG T+   +        
Sbjct: 23596 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETF---RLEADVHGK 23652

Query: 503   PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSE 561
             P   I +    +E E       K T       VK+  R    ++ L ASN  G KS P  
Sbjct: 23653 PLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVN 23712

Query: 562   VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
             V V     DRPGPP  P+    VTS   S+ W PP  +GGS+I  Y++E  + +  A  W
Sbjct: 23713 VKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLA--W 23766

Query: 622   EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPR 678
              V  S   T     T L  G  Y  R   ++  G  +  ES PV  +   + PG  +   
Sbjct: 23767 TVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLE 23826

Query: 679   VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA---SEVYHGPELECTVGNLLP 735
             V    K   + + W+ P S+ G E+  Y VE  +   +           +L   V  L  
Sbjct: 23827 VTNIAKDS-MTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTE 23885

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESPD- 791
                Y FRV A N  G G  S  +    A  P   PG      I  T    + + W  P  
Sbjct: 23886 DHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIY 23945

Query: 792   SSGADISEYRLEWGE-DEESLELIYHGTD---TRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
               G++I  Y +E  + DEE  +++   T    TRFEI  L    +Y  R+ A N+ G G 
Sbjct: 23946 DGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE 24005

Query: 848   YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-------------------L 888
              +         S P  V     LE   LD   +     +V                   +
Sbjct: 24006 AT---------SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEI 24056

Query: 889   NWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
              W       ++ +     +  T +++ N       D      Y +++    E  +G  S 
Sbjct: 24057 TWSREEGEFTDKVQIEKGVNYTQLSIDNC------DRNDAGKYILKL----ENSSGSKSA 24106

Query: 949   FIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNK 1002
             F+  K    P  P  L        S  L W      G +  K +  +      + E   K
Sbjct: 24107 FVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID------KRESTRK 24160

Query: 1003  RFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR 1061
              + ++    S T +KV+ LTE   Y FR+ A +E G G   ET         P       
Sbjct: 24161 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 24220

Query: 1062  VTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             +T +   S  ++WE      G  V  Y++++      ++  V + +     ++GL +  +
Sbjct: 24221 LTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQE 24280

Query: 1121  YRFRVCA 1127
             Y+FRV A
Sbjct: 24281 YQFRVKA 24287



 Score =  145 bits (365), Expect = 3e-34
 Identities = 190/781 (24%), Positives = 303/781 (38%), Gaps = 90/781 (11%)

Query: 361   SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEG 419
             +V G+ SE +             P K+     +S+T+ W+ P +D G+ ++ Y++E  + 
Sbjct: 29815 NVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDA 29874

Query: 420   KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVV--CYTLGNIPQM 477
              R          ++   K T+L     Y FR+AA N  G   Y Q  V  C +   IP  
Sbjct: 29875 HRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 29934

Query: 478   PSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT-CTVK 536
             P   ++       +TL W  PE     +V  Y +E +E   D           +T     
Sbjct: 29935 PETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRST 29994

Query: 537   NLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
              L    +Y+ R+TA N  G    S PS+ +V       PG P  P V    T    S+ W
Sbjct: 29995 GLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVT-DTTRTSVSLAW 30053

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYS--GSATEYTFTHLKPGTLYKLRACCIS 651
               P+D GGS++  YL+E+     + ++W    +      EYT THL  G  Y+ R    +
Sbjct: 30054 SVPEDEGGSKVTGYLIEMQ--KVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACN 30111

Query: 652   TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDVPASESGCEVSEYSVEM 710
              GG  + +E          PG  +   +L  P ++ +   +  +   + G  V   ++ +
Sbjct: 30112 AGGPGEPAE---------VPGTVKVTEMLEYPDYELDERYQEGIFVRQGG--VIRLTIPI 30160

Query: 711   T-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---------- 759
               +P  +      G ++          T     ++  + G  G Y  V E          
Sbjct: 30161 KGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYI 30220

Query: 760   ----ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELI 814
                 I +   P G  +   I       V V W  P D  GADI  Y L   E  E  +  
Sbjct: 30221 KVRVIGSPNSPEGPLEYDDIQVR---SVRVSWRPPADDGGADILGYIL---ERREVPKAA 30274

Query: 815   YHGTDTRFE-----IRDLLPAAQYCCRLQAFNQAGAG---PYSELVLCQTPASAPDPVST 866
             ++  D+R       ++ L    +Y  R+ A NQ G        E V  +TP + P+P S 
Sbjct: 30275 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSN 30334

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTSI--------TVGNT 917
                   E LD    S S    L+W  P ++ GS +  Y I+  +TS         T   T
Sbjct: 30335 ----PPEVLDVTKSSVS----LSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 30386

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTR-PLPPLPPRLECAAAGPQS 973
             TM+ +  L+P+  Y+ RI A N++G     P S+ +  K     P  P  LE  +    S
Sbjct: 30387 TMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDS 30446

Query: 974   LKLKWGDSNSKTHAAEDI----VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
             + L+W     +    ++I    V   Q  D   +  +  R     + +  L E T Y FR
Sbjct: 30447 VTLQW--EKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFR 30504

Query: 1030  IQAASEAG-EGPFSETYTFST--TKSVPPTIK------APRVTQLEGNSCEILWETVPSM 1080
             + A +E G   P     +  T  T    P I+        ++ +    SC+I+   +P +
Sbjct: 30505 VFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDI 30564

Query: 1081  K 1081
             K
Sbjct: 30565 K 30565



 Score =  144 bits (363), Expect = 5e-34
 Identities = 208/860 (24%), Positives = 341/860 (39%), Gaps = 95/860 (11%)

Query: 350   DYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSK 408
             +Y  R+YA+  +     S+P  + T     + P  P++   +KS+++L W  P  D GSK
Sbjct: 19161 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 19220

Query: 409   ITNYLLE-----WDEGKR-NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGY 462
             I  Y +E      D+  R N+   Q     Q+    T L     Y FR  AR  +  S  
Sbjct: 19221 IIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEEKAQYQFRAIARTAVNISPP 19277

Query: 463   SQ--EVVCYTLGNIPQMPSAPRL-VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND 519
             S+  + V     N+P     PR+ +   +  +    +    C    V    +     + D
Sbjct: 19278 SEPSDPVTILAENVP-----PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 19332

Query: 520   N-LFHP----KYTGEDLTCTVK--NLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDR 571
               L  P    K   +   CT++  ++ R     + +TA N+ G KS   ++ V     D+
Sbjct: 19333 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL----DK 19388

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP    +    +     + W+PP ++GGSEI  Y+++  +  S  N  +V+ +   T 
Sbjct: 19389 PGPPASVKINKMYSDRAM-LSWEPPLEDGGSEITNYIVDKRE-TSRPNWAQVSATVPITS 19446

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH 689
              +   L  G  Y+ R C  +  G      +E    +     PG+C PP V+       + 
Sbjct: 19447 CSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPP-VISNITKDHMT 19505

Query: 690   LEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECTVG--NLLPGTVYRFRVRAL 746
             + W  PA + G  ++ Y +E  E + V  ++V   P +E T+    L  GT Y FRV A+
Sbjct: 19506 VSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAI 19565

Query: 747   NDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL 802
             N  G G  SD S+   A     PPG    P +  T    V + W  P    G+ I  Y +
Sbjct: 19566 NKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLV 19625

Query: 803   EWGEDEES----LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
             E    +        L  +   TRFE+  L+   QY  R+ A N+ G   YS+      P+
Sbjct: 19626 EVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG---YSD------PS 19676

Query: 859   SAPDP--VSTLCVLEEEPLDA-----------------YPDSPSACLVLNWEEPCNNGSE 899
               PD      + +  E  LDA                  P        + W +P  N  +
Sbjct: 19677 DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD 19736

Query: 900   ILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
              +   +D+  T         +V K       Y + ++  N  G   ++  +K    P PP
Sbjct: 19737 RIG--LDIKSTDFDTFLRCENVNK--YDAGKYILTLE--NSCGKKEYTIVVKVLDTPGPP 19790

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED-RNKRFISIYRGPSHT-YKV 1017
             +   +        S  + W +       +  I Y +Q  D   K + ++    S T ++V
Sbjct: 19791 V--NVTVKEISKDSAYVTW-EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRV 19847

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETV 1077
               L E   Y FR+ A +E G G   ET         P  +   +V  +  +SC I W+  
Sbjct: 19848 ANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKP 19907

Query: 1078  PSMKGDP-VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQ 1136
              S  G   + Y++  L   E+++++V K     +    L    +Y FRV A        +
Sbjct: 19908 HSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA--------E 19958

Query: 1137  ELSGAFSPSAAFVLQRSEVM 1156
               +G  +PS   V+ R +V+
Sbjct: 19959 NENGEGTPSEITVVARDDVV 19978



 Score =  144 bits (363), Expect = 5e-34
 Identities = 211/906 (23%), Positives = 353/906 (38%), Gaps = 106/906 (11%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKII---YSGEE 337
             KP + N+ +  + L+W  PV      + G S    + V   ++      K+     SG E
Sbjct: 27762 KPVIYNVTSDGMSLTWDAPV------YDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 27815

Query: 338   LECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTL 397
                    L    DY  RVYA  ++   S S+P  FT      + P  P     ++ ++TL
Sbjct: 27816 YRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITL 27873

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
             +W  P+ D GSKI  Y +E  +G  N  + +C F     C+  +T L P   Y FR+ AR
Sbjct: 27874 KWNPPLRDGGSKIVGYSIEKRQG--NERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIAR 27931

Query: 455   NDIGT---SGYSQEVVCYTLGNIPQMPS-APR-----LVRAGITWVTLQWSKPEGCSPEE 505
             N +GT      S  ++     N+P +    P      ++++G +      +  +G     
Sbjct: 27932 NAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIK--ALVQGRPVPR 27989

Query: 506   VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             V  +   ++ ++  N+      G   +  V++  R  +  + + A N  G S  +E+ V 
Sbjct: 27990 VTWFKDGVEIEKRMNMEITDVLGST-SLFVRDATRDHRGVYTVEAKNASG-SAKAEIKVK 28047

Query: 566   TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VA 624
                 D PG    P+    +T    ++ WD P ++G + I  Y++E  + +  A  W  + 
Sbjct: 28048 VQ--DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLA--WALIE 28103

Query: 625   YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV-----RTLSIAPGQCRPPRV 679
                 A  YT   L  G  Y+ R   ++  G  +  +S PV      T+  APG   P  +
Sbjct: 28104 DKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI 28163

Query: 680   LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV--ASEVYHGP--ELECTVGNLLP 735
              G      + L W  P S+ G E+ +Y +E  E +       +   P  E    V  L  
Sbjct: 28164 TG----NSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTE 28219

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESP-D 791
             G  Y F V A N  G GP S +S +        PPG      ++ T    V + W  P  
Sbjct: 28220 GNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVF 28279

Query: 792   SSGADISEYRLEWGEDEESLELIYHGTD------TRFEIRDLLPAAQYCCRLQAFNQAGA 845
               G +I  Y +E  + +      +H  +      TR+ + DL    +Y  R+ A N AG 
Sbjct: 28280 DGGMEIIGYIIEMCKADLG---DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 28336

Query: 846   GPYSEL---VLCQTPASAPDPVSTLCVLEEEPLD---------AYPDSPSACLVLNWEEP 893
             G   E+   +      +AP+        +   +          AY   P+   V  W +P
Sbjct: 28337 GDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAV--WSKP 28394

Query: 894   CNNGSEILAYTIDLGDT----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
              +N    L+   D+  T    ++TV N   +          Y + ++  N  G+   +  
Sbjct: 28395 DSN----LSLRADIHTTDSFSTLTVENCNRN------DAGKYTLTVE--NNSGSKSITFT 28442

Query: 950   IKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDRNKRFI 1005
             +K    P PP P   +    G  S  L W     D  ++ H      Y ++  + ++R  
Sbjct: 28443 VKVLDTPGPPGPITFKDVTRG--SATLMWDAPLLDGGARIHH-----YVVEKREASRRSW 28495

Query: 1006  SIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRV 1062
              +   +     +KV  L E   Y FR+ A +E G G P+        T+   P  +   V
Sbjct: 28496 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLD-V 28554

Query: 1063  TQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDY 1121
                  +S  + W       G  +  Y+L++       + +    ++ TF +  L   T+Y
Sbjct: 28555 VDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEY 28614

Query: 1122  RFRVCA 1127
              FRV A
Sbjct: 28615 EFRVKA 28620



 Score =  143 bits (360), Expect = 1e-33
 Identities = 217/889 (24%), Positives = 336/889 (37%), Gaps = 142/889 (15%)

Query: 336   EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCA-----PECPFPPKLAHR 390
             E  +C++  L    +Y  RV A     K  C  PV             P  P       R
Sbjct: 15250 ERSKCDITGLLEGQEYKFRVIAKN---KFGCGPPVEIGPILAVDPLGPPTSPERLTYTER 15306

Query: 391   SKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPA 444
             +KS++TL WK P  NG S I  Y++E    KR          +++ C  T      L   
Sbjct: 15307 TKSTITLDWKEPRSNGGSPIQGYIIE----KRRHDKPDFERVNKRLCPTTSFLVENLDEH 15362

Query: 445   MGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQMPSAPRLVRA----------------- 486
               Y FR+ A N+IG S  S  + V      +P        VR                  
Sbjct: 15363 QMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADV 15422

Query: 487   -GITWVTLQWSKPEGC--SPEEVITYTLE--IQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
              G+    ++WSK E     P + +  T E   + +    L  PK   ED           
Sbjct: 15423 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED----------- 15471

Query: 542   TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
              +  + +TASN  G    +   V     DRP PP R L    + +    + WD P DNGG
Sbjct: 15472 -KGTYTVTASNRLGSVFRN---VHVEVYDRPSPP-RNLAVTDIKAESCYLTWDAPLDNGG 15526

Query: 602   SEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHS-QC- 658
             SEI  Y+++  D + +  +W EV  +     Y    L P   Y+ R   ++  G S +C 
Sbjct: 15527 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECK 15586

Query: 659   SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVA 717
             S+ + ++     PG    P+VL R K   + + W  P    G  ++ Y +E  E      
Sbjct: 15587 SDKVVIQDPYRLPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYWLEKREEGSPYW 15645

Query: 718   SEVYHGP-------ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG---PP 767
             S V   P        +E  V  LL G  Y+FR  A+N  G GP S+ S+   A     PP
Sbjct: 15646 SRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPP 15705

Query: 768   GQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGT 818
             G    P +       + +GW+ P    G+ I  Y +E        W    E  +LI   T
Sbjct: 15706 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI---T 15762

Query: 819   DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAY 878
                  + +L    +Y  R++A N+AG    S+    + PA+          ++EEP    
Sbjct: 15763 TCECVVPNLKELRKYRFRVKAVNEAGESEPSD-TTGEIPATD---------IQEEPEVFI 15812

Query: 879   PDSPSACLVLNWEEPCNNGSEILAYTIDLG---------------------------DTS 911
                   CLV      C  GS+I    +  G                           D  
Sbjct: 15813 DIGAQDCLV------CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQ 15866

Query: 912   I-TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAG 970
             + T  N+++ ++ +     T +  I A N+ G    +  +K    P PP   ++     G
Sbjct: 15867 LETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRG 15926

Query: 971   PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRI 1030
                L  K  D +        ++    ++ +    ++   G S T+ V  L     Y FR+
Sbjct: 15927 SCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG-STTFVVPDLLSEQQYFFRV 15985

Query: 1031  QAASEAGEGPFSETYTFSTTKS----VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV- 1085
             +A +  G GP  ET   +T +       P IK  ++  +  N+  + W+   +  G PV 
Sbjct: 15986 RAENRFGIGPPVETIQRTTARDPIYPPDPPIKL-KIGLITKNTVHLSWKPPKNDGGSPVT 16044

Query: 1086  NYILQVLV-----GRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
             +YI++ L       ++  ++Q  K   EE  F +  L    +Y FRV A
Sbjct: 16045 HYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 16093



 Score =  142 bits (359), Expect = 1e-33
 Identities = 209/893 (23%), Positives = 365/893 (40%), Gaps = 77/893 (8%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             ++++   + +L+W PP         G S   +Y V       +  +K+  + ++      
Sbjct: 13792 ITDVTNESCLLTWNPP------RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKAT 13845

Query: 344   DLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
              L P  +Y  RV A  MY   +   + P++       P  P   + +  +K ++TL W  
Sbjct: 13846 KLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCE 13905

Query: 402   PIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHC--KLTKLCPAMGYTFRLAARNDIG 458
             P D+G S IT Y +E  +   +   R C     K    ++  L     Y FR+ A N  G
Sbjct: 13906 PDDDGGSPITGYWVERLDPDTDKWVR-CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAG 13964

Query: 459   T---SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                 S  ++ ++     + P  P  P +   G T V L W+KPE     ++ +Y +E+ +
Sbjct: 13965 PGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLK 14024

Query: 516   DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV---LVCTTSPDRP 572
                D               +  L    +Y FR+ A N  G+S PSE    ++C      P
Sbjct: 14025 TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPP 14084

Query: 573   GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
              PP R L    +T +   +KW  P+ +GGS I  Y++E  D   +  Q  V  +   T+ 
Sbjct: 14085 SPP-RWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQ-TVDTTVKDTKC 14142

Query: 633   TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPGQCRPPRVLG--RPKHKE 687
             T T L  G+LY  R    +  G S  +E   S+  +     PG   PP  L       + 
Sbjct: 14143 TVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPG---PPYALAVVDVTKRH 14199

Query: 688   VHLEWDVPASESGCEVSEYSVEMTE---PEDVASEVYHGPELECTVGNLLPGTVYRFRVR 744
             V L+W+ P ++ G  +  Y +E  E      V +    GP+    V +++ GT  +F+VR
Sbjct: 14200 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 14259

Query: 745   ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC---VLVGWESPDSSGAD-ISEY 800
             A N+ G G  S+ +EI +   P      P      D     + + W+ P+ +G   I  Y
Sbjct: 14260 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 14319

Query: 801   RLEW---GEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
              +E    G ++          D +F++ + ++P  +Y  R++A N  G    SE+   V+
Sbjct: 14320 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 14379

Query: 854   CQTPASAPD---PVSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
              + P   P        + V+E E L    P        ++W +   +G E+ A       
Sbjct: 14380 AKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHK---DGKEVKA------S 14430

Query: 910   TSITVGNTTMHVMKDL-LPETT------YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPP 962
               +T+ N   H+   L +P++       Y I ++  N++G+   S  I  K   LP    
Sbjct: 14431 DRLTMKND--HISAHLEVPKSVRADAGIYTITLE--NKLGSATAS--INVKVIGLPGPCK 14484

Query: 963   RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR-FISIYRGPSH-TYKVQRL 1020
              ++ +     S KL W +          + Y L+  +  +R +I +  G +  ++ V+ L
Sbjct: 14485 DIKASDITKSSCKLTW-EPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDL 14543

Query: 1021  TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCE---ILWETV 1077
                  Y FR++A ++ G G + E       +        P   ++   + E   I W+  
Sbjct: 14544 IPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP 14603

Query: 1078  PSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
                 G  +  YI++ +   E  +K+  +      T+   GL+   +Y+FRV A
Sbjct: 14604 LYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRA 14656



 Score =  142 bits (359), Expect = 1e-33
 Identities = 212/900 (23%), Positives = 347/900 (38%), Gaps = 98/900 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +++ + +   +LSW PP+        G S   +Y V   +  R    ++  +     C++
Sbjct: 19396 KINKMYSDRAMLSWEPPL------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSV 19449

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
             + L    +Y  R+ A   Y       +EP         P    PP +++ +K  +T+ WK
Sbjct: 19450 EKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWK 19509

Query: 401   APIDN-GSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              P D+ GS IT YLLE        W +  R           ++  K T L     Y FR+
Sbjct: 19510 PPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-------ERTLKATGLQEGTEYEFRV 19562

Query: 452   AARNDIG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
              A N  G    S  S+          P  P+ P++     + V+L W KP       +I 
Sbjct: 19563 TAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIG 19622

Query: 509   YTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             Y +E++  ++DN        ++L  T   V  L   TQY+FR+ A N  G S PS+V   
Sbjct: 19623 YLVEVKRADSDNWVRCNLP-QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDK 19681

Query: 566   TTSPDRPGPPTRPL---------VKGPVTSHGF-SVKWDPPKDNGGSEILKYLLEITDGN 615
                 D   PP   L         ++  VT   +  VK  PP             +IT   
Sbjct: 19682 HYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP------------KITWSK 19729

Query: 616   SEAN-QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQC 674
                N +  +     +T++  T L+   + K  A        + C +      + +     
Sbjct: 19730 PNVNLRDRIGLDIKSTDFD-TFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 19788

Query: 675   RPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---- 729
              P  V  +   K+  ++ W+ P  + G  +  Y V   +  D   + +     EC+    
Sbjct: 19789 PPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV---QKRDAERKSWSTVTTECSKTSF 19845

Query: 730   -VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE 788
              V NL  G  Y FRV A N+ G G   +  +   A+  PG      +         +GW+
Sbjct: 19846 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWK 19905

Query: 789   SPDSSGAD-ISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
              P S G   I  Y +++  +E   + +      ++  +DL    +Y  R+ A N+ G G 
Sbjct: 19906 KPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGT 19965

Query: 848   YSEL-VLCQTPASAPD----PVSTLCVLEEE--------PLDAYPDSPSACLVLNWEEPC 894
              SE+ V+ +    APD     +  LC L +E        P+   P +PS    ++W++  
Sbjct: 19966 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP-APS----VSWKK-- 20018

Query: 895   NNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
               G + LA    +   S  V NTT+ ++ D       +  I   N  G    +  IK   
Sbjct: 20019 --GEDPLATDTRVSVESSAV-NTTL-IVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVG 20074

Query: 955   RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED--RNKRFISIYRGPS 1012
             +P  P  P ++      +++ LKW         +E   Y L+  D   NK          
Sbjct: 20075 KPGIPTGP-IKFDEVTAEAMTLKWAPPKD-DGGSEITNYILEKRDSVNNKWVTCASAVQK 20132

Query: 1013  HTYKVQRLTEFTCYSFRIQAASE--AGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC 1070
              T++V RL E   Y+FR+ A ++   GEG  SE         VP     P +  +  +S 
Sbjct: 20133 TTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSV 20192

Query: 1071  EILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              + W       G P+  Y L+        +K+  K       F+++GL    +Y FRV A
Sbjct: 20193 SLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMA 20252



 Score =  142 bits (358), Expect = 2e-33
 Identities = 226/946 (23%), Positives = 363/946 (38%), Gaps = 128/946 (13%)

Query: 260   SDLQEYELEVKRVQDILSG------IEKPQV-------SNIQARAVVLSWAPPVGLSCGP 306
             SD  +Y + +K V     G      + KP +         + A A+ L WAPP       
Sbjct: 20048 SDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPP------K 20101

Query: 307   HSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYA--MYNSVKG 364
               G S   +Y +   D   +       + ++    +  L    +Y  RV A   Y   +G
Sbjct: 20102 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEG 20161

Query: 365   SCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNS 423
               SEP+        P+ P PP +      S++L W  P   G S IT Y LE+ E  RNS
Sbjct: 20162 LKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE--RNS 20219

Query: 424   GFRQCFFGS---QKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
                +    +    +  K+T L   + Y FR+ A N  G    S         +    P  
Sbjct: 20220 LLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK 20279

Query: 481   PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTG-EDLTCTVKNLK 539
             P ++      VTL W++P+     ++  Y +E ++  + +     +    +   TV +L 
Sbjct: 20280 PEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLV 20339

Query: 540   RSTQYKFRLTASNTEGK-SCPSE---VLVCTTSPDRPGPPTRPLVKGPVTS--------H 587
                +Y+FR+ A NT G  S PSE    ++C    + P     P +K  +T         +
Sbjct: 20340 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLN 20399

Query: 588   GFSVKWDP-PKDN---GGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP-G 640
               S+   P PK +    G +I    +        ++   + Y+    A EYT T   P G
Sbjct: 20400 AISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459

Query: 641   TLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESG 700
             T                  E + V  L + PG   P  +      K   L W  P  + G
Sbjct: 20460 TKV----------------EHVKVTVLDV-PGPPGPVEISNVSAEKAT-LTWTPPLEDGG 20501

Query: 701   CEVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGP--YSD 756
               +  Y +E  E   +   V       C      L+ G  Y FRV A+N  G G    S+
Sbjct: 20502 SPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSE 20561

Query: 757   VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIY 815
               ++    GPPG  + P +S        V W+ P D  G++I+ Y +E  E ++SL  + 
Sbjct: 20562 PVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE-KKSLRWVR 20620

Query: 816   H----GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLC 868
                   +D R ++  L   + Y  R+ A N+AG GP SE    VL +  A  P P S   
Sbjct: 20621 AIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPH 20680

Query: 869   VLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID---------LGDTSITVGNTT 918
             V          D+      L W +P  + G EI  Y ++         + DT+ T    T
Sbjct: 20681 VT---------DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 20731

Query: 919   MHVMKDLLPETTYRIRIQAINEIGAG-----PFSQFIKAKTRPLPPLPPRLECAAAGPQS 973
               V+ DL  +  Y  RI AIN+ G G     P  + ++ +      + P  E  A   ++
Sbjct: 20732 QFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVERE------MAPDFELDAELRRT 20785

Query: 974   LKLKWGDS-----NSKTHAAEDIVYT---LQLEDRNKRFISIYRGPSHTYK-VQRLTEFT 1024
             L ++ G S       K   A ++ +T   + L++R     +I    S T   +     + 
Sbjct: 20786 LVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNR----ANIENTESFTLLIIPECNRYD 20841

Query: 1025  CYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP 1084
                F +   + AG+      +        P  +   R T +  +S  + W+ +P + G  
Sbjct: 20842 TGKFVMTIENPAGK---KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWD-LPLIDGGS 20897

Query: 1085  --VNYILQVLVGRESEYK-QVYKGEEATFQISGLQTNTDYRFRVCA 1127
                NYI++        Y     K  + T++++GL    +Y FRV A
Sbjct: 20898 RITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMA 20943



 Score =  142 bits (358), Expect = 2e-33
 Identities = 222/931 (23%), Positives = 360/931 (38%), Gaps = 93/931 (9%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S      +  ++  +V LSW PP+        G +   +Y V   +  R     
Sbjct: 25194 RVLDSPSAPVNLTIREVKKDSVTLSWEPPL------IDGGAKITNYIVEKRETTRKAYAT 25247

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPP-- 385
             I  +  +    +++L+    Y+ RV A       +    +EPV  +      E P PP  
Sbjct: 25248 ITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVS------EPPLPPGR 25301

Query: 386   -KLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
               L   ++++ T++W+ P  D GSKIT Y++E  + K +  +  C         ++ L  
Sbjct: 25302 VTLVDVTRNTATIKWEKPESDGGSKITGYVVEM-QTKGSEKWSTCTQVKTLEATISGLTA 25360

Query: 444   AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA--PRLVRAGITWVTLQWSKPEGC 501
                Y FR+AA N+ G S   Q  V     +I   PS   P           L+   P   
Sbjct: 25361 GEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKG 25420

Query: 502   SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPS 560
              P+  + +  + Q  +     +   +    + ++K   +     + L  SN+ G  + P 
Sbjct: 25421 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 25480

Query: 561   EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQ 620
              ++V     DRPGPP  P+    V+    ++ W+PP+ +GG +I  Y++E  +  S    
Sbjct: 25481 TIIVL----DRPGPPG-PIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTS--TT 25533

Query: 621   WEVAYSGSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
             W +     A T      L  G+ Y+ R C  +  G S  SES  V    +A     PP  
Sbjct: 25534 WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV----VAEYPFSPPGP 25589

Query: 680   LGRPK-----HKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTV 730
              G PK        + + W VP ++ G  V  Y +E  E   +    A+++    + +  V
Sbjct: 25590 PGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIA-DTQMKV 25648

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGW 787
               L  G +Y +RV A N  G G  S   E   A     PPGQ   P ++      V + W
Sbjct: 25649 SGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQ---PEVTNITRKSVSLKW 25705

Query: 788   ESPD-SSGADISEYRLEWGE--DEESLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQA 843
               P    GA I+ Y +E  E  D   L+  Y    +T FE+ +L    +Y  R+ A N A
Sbjct: 25706 SKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAA 25765

Query: 844   GAGPYSELVLCQTPASAPDPV------------STLCVLEEEPLDAYPDSPSACL-VLNW 890
              +   SE      P    D V              + V   E L    D     L V++W
Sbjct: 25766 DS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 25823

Query: 891   EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
                  +G EI           I+  N T+  +KD +   T +  +   N  G    +   
Sbjct: 25824 ---AKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNC 25877

Query: 951   KAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
             K   +P PP  P LE      +   L WG       A  D  Y ++  + +    +I  G
Sbjct: 25878 KVLDKPGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADID-YYIVEKRETSHLAWTICEG 25935

Query: 1011  PSH--TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK--SVPPTIKAPRVTQLE 1066
                  + KV +L +   Y FR+   ++ G G   E+         +VP    +  +T + 
Sbjct: 25936 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 25995

Query: 1067  GNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKGEEATFQI--SGLQTNTDYRF 1123
               S  + W    S  G  ++ YI++        + +V K      ++  +GL+   +Y +
Sbjct: 25996 KESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEY 26055

Query: 1124  RVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             RV A        +  +G   PS    L R+E
Sbjct: 26056 RVYA--------ENAAGLSLPSETSPLIRAE 26078



 Score =  141 bits (355), Expect = 4e-33
 Identities = 217/905 (23%), Positives = 352/905 (38%), Gaps = 95/905 (10%)

Query: 292   VVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
             +V+SW PP+        G S   +Y +   + G+D    +  +  +  C +  L    DY
Sbjct: 16929 MVISWKPPLD------DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDY 16982

Query: 352   HVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKI 409
               R++A  +Y       S+ +        P+ P  P +   +K S  + W  P D G  I
Sbjct: 16983 IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPI 17042

Query: 410   TNYLLEWDE--GKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG---TSGYSQ 464
             TNY+LE  E   KR +   +         ++  L     Y FR++A N+IG    S  S+
Sbjct: 17043 TNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSK 17102

Query: 465   EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
              V        P  P  P  +      V L W  P      +++ Y +E Q+  ++     
Sbjct: 17103 PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRA 17162

Query: 525   KYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP------ 575
              +T E    T   V  L+    YKFR+ A N  G+S P+ V       DR  PP      
Sbjct: 17163 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDA 17222

Query: 576   ----TRPLVKGPVTSHGFSVKWDP-PKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
                  + +  G        +K  P PK       + +  E  D  ++A + +V   GS  
Sbjct: 17223 NMAREQHIKVGDTLRLSAIIKGVPFPK-------VTWKKEDRDAPTKA-RIDVTPVGSKL 17274

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI-APGQCRPPRVL--GRPKHKE 687
             E      + G +Y L      T  +   S+++ V+ L +  PG   PPR L     +   
Sbjct: 17275 EIRNAAHEDGGIYSL------TVENPAGSKTVSVKVLVLDKPG---PPRDLEVSEIRKDS 17325

Query: 688   VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH-----GPELECTVGNLLPGTVYRFR 742
              +L W  P  + G  ++ Y VE     DVAS  +        +      +L  G  Y FR
Sbjct: 17326 CYLTWKEPLDDGGSVITNYVVER---RDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFR 17382

Query: 743   VRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             V A N  G GP+ +  +   A     PPG  K           V + W  PD   G+ I+
Sbjct: 17383 VAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT 17442

Query: 799   EYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAG-PYSEL-VLC 854
              Y +E+ ++E + + I   T T  E  +  L     Y  R++A N  G G P + + + C
Sbjct: 17443 GYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIEC 17501

Query: 855   QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP----CNNGSEILA---YTIDL 907
             Q     P     + ++E   + A        ++     P      +GSEI     YT++ 
Sbjct: 17502 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVET 17561

Query: 908   GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECA 967
              + S      ++  +K+ L   T   +I   N  G+   +  +     P PP  P +   
Sbjct: 17562 DNFS------SVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP-INIL 17614

Query: 968   AAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLED-RNKRFISIYRGPSHT-YKVQRLTEFT 1024
                P+ + + W     K      ++ Y ++ +D R   +  +  G S T  K+  L +  
Sbjct: 17615 DVTPEHMTISW--QPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGC 17672

Query: 1025  CYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKG 1082
              Y FR++A ++ G G P   T T +  K  PP+    P VT +  N+  + W    S  G
Sbjct: 17673 EYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGG 17732

Query: 1083  DPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
              P+            ++ +V K    +  F+++GL     Y FRV A        + L+G
Sbjct: 17733 SPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFA--------ENLAG 17784

Query: 1141  AFSPS 1145
                PS
Sbjct: 17785 LSKPS 17789



 Score =  140 bits (353), Expect = 7e-33
 Identities = 167/655 (25%), Positives = 264/655 (40%), Gaps = 55/655 (8%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
             KP V ++   +V L+W  P       H G +   SY + +   G D   ++       + 
Sbjct: 13989 KPTVKDVGKTSVRLNWTKP------EHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQH 14042

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTL 397
              L  L    +Y  RV A+  + +   SEP            P PP+   + + +K++  L
Sbjct: 14043 LLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADL 14102

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
             +W  P  D GS ITNY++E  + +R              C +T L     Y FR+AA N 
Sbjct: 14103 KWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENA 14162

Query: 457   IGTSGYSQ---EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             IG S Y++    V+       P  P A  +V      V L+W  P+      +  Y +E 
Sbjct: 14163 IGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEK 14222

Query: 514   QEDENDNLFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
             +E          K  G D    V ++   T+ +F++ A N  G   PSE     +  D  
Sbjct: 14223 KERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPT 14282

Query: 573   GPPTRPLVKGPVTSHG---FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
              PP+ PL    VT  G    ++ W PP+ NGGS I+ Y +E+    +E  +W    S   
Sbjct: 14283 SPPSPPLDLH-VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTE--KWMRVNSRPI 14339

Query: 630   TEYTF---THLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK 686
              +  F     + P   Y LR   ++  G S+ SE +    ++  P  C+P   +    H 
Sbjct: 14340 KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSE-ISENVVAKDP-DCKP--TIDLETHD 14395

Query: 687   EVHLEWD---VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR--- 740
              + +E +   +P       V   S      E  AS+         +    +P +V     
Sbjct: 14396 IIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAG 14455

Query: 741   -FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
              + +   N  G    S   ++    GP    KA  I  T   C L  WE P+   G  I 
Sbjct: 14456 IYTITLENKLGSATASINVKVIGLPGPCKDIKASDI--TKSSCKLT-WEPPEFDGGTPIL 14512

Query: 799   EYRLEWGEDEESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
              Y LE  E      +     + +  + ++DL+P  +Y  R++A N+ G G Y EL   V+
Sbjct: 14513 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 14572

Query: 854   CQTPASAPDPVSTLCVLEEEPLDAYPDSPSA-CLVLNWEEPC-NNGSEILAYTID 906
              Q P   PDP          P+D    +P+A  + + W+ P  + GS+I+ Y I+
Sbjct: 14573 AQDPKQPPDP----------PVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIE 14617



 Score =  140 bits (352), Expect = 9e-33
 Identities = 225/902 (24%), Positives = 350/902 (38%), Gaps = 115/902 (12%)

Query: 257   SNDSDLQEYELEVKRVQDILSG------IEKPQV------SNIQARAVVLSWAPPVGLSC 304
             S  SD   Y L+++     +SG      I +P         +I   +V L+W PP     
Sbjct: 13457 SERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGG 13516

Query: 305   GPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKG 364
              P +G      Y V   +  R    K++    +LE  + DL    +Y  +V A      G
Sbjct: 13517 SPLTG------YVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPG 13570

Query: 365   S---CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGK 420
                   EPV+ +T +  P+ P   K   R+ +S+ L W  P  D GS+I  Y++E     
Sbjct: 13571 EPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVE----- 13625

Query: 421   RNSGFRQCFFGSQK-----------HCKLTKLCPAMGYTFRLAARNDIGTSGYS---QEV 466
                   +C  GS K             ++T L     Y +R+ A N  G S  S   +E+
Sbjct: 13626 ------RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEI 13679

Query: 467   VCYTLGNIPQMPSAPRLVRAGIT---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFH 523
                     P++    +L+ AG+T      ++        PE  IT+T      + D    
Sbjct: 13680 QAVDTQEAPEIFLDVKLL-AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRIT 13738

Query: 524   PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
              +   +  T T+ + KRS    + + A N  G++     +V     D+PGPP    +   
Sbjct: 13739 IENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRAT---AVVEVNVLDKPGPPAAFDITD- 13794

Query: 584   VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTL 642
             VT+    + W+PP+D+GGS+I  Y++E    +SE   W +++ +   T +  T L P   
Sbjct: 13795 VTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV--WHKLSSTVKDTNFKATKLIPNKE 13852

Query: 643   YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE--------VHLEWDV 694
             Y  R    +  G  +  ++ P+     A  Q  PP   G P   E        V L W  
Sbjct: 13853 YIFRVAAENMYGVGEPVQASPI----TAKYQFDPP---GPPTRLEPSDITKDAVTLTWCE 13905

Query: 695   PASESGCEVSEYSVEMTEPE-DVASEVYHGPELECT--VGNLLPGTVYRFRVRALNDGGY 751
             P  + G  ++ Y VE  +P+ D        P  + T  V  L     YRFRV A N  G 
Sbjct: 13906 PDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGP 13965

Query: 752   GPYSDVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE- 806
             G  S  +E   I     PP     P +       V + W  P+   GA I  Y +E  + 
Sbjct: 13966 GKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKT 14025

Query: 807   -DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE---LVLCQTPASAPD 862
               +E + +      T+  +  L+   +Y  R++A N+AG    SE    VLC+     P 
Sbjct: 14026 GTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPS 14085

Query: 863   PVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTIDLGDTSITVGNTTMHV 921
             P   L V+      A          L W  P  + GS I  Y ++  D       T    
Sbjct: 14086 PPRWLEVINITKNTA---------DLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 14136

Query: 922   MKD-------LLPETTYRIRIQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAG 970
             +KD       L   + Y  R+ A N IG   +++    + AK     P PP  L      
Sbjct: 14137 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVT 14196

Query: 971   PQSLKLKWGDSNSKTHAAEDIV-YTLQLEDR-NKRFISIYR--GPSHTYKVQRLTEFTCY 1026
              + + LKW     K      I  Y ++ ++R   R++   +  GP   ++V  + E T  
Sbjct: 14197 KRHVDLKW--EPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 14254

Query: 1027  SFRIQAASEAGEGPFS---ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
              F+++A +EAG G  S   E  +     S P       VT        I W+      G 
Sbjct: 14255 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 14314

Query: 1084  PV 1085
             P+
Sbjct: 14315 PI 14316



 Score =  140 bits (352), Expect = 9e-33
 Identities = 224/898 (24%), Positives = 357/898 (39%), Gaps = 91/898 (10%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             + +I    V L+W  P       H G S    Y +    KG D ++  I + + LEC ++
Sbjct: 20973 IMDITKSTVSLAWPKP------KHDGGSKITGYVIEAQRKGSD-QWTHITTVKGLECVVR 21025

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSE--PVSFTTHSCAPECPFP---PKLAHRSKSSLTLQ 398
             +L    +Y  +V A+ ++ + +  E  PV     +  PE        KL   +K+   ++
Sbjct: 21026 NLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVI-AKAGDNIK 21084

Query: 399   WKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAAR 454
              + P+    K T   + W +G    K+          +     + +   +    + L AR
Sbjct: 21085 VEIPVLGRPKPT---VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTAR 21141

Query: 455   NDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             N +G  G   +V+   + +IP  P+ P +       +VT  W  PE      +  Y +E+
Sbjct: 21142 NIVGEVG---DVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 21198

Query: 514   QEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLVCTTSPDR 571
             ++ ++        T    T     L    +Y+FR+ A N  G      S  +V       
Sbjct: 21199 RQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKV 21258

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP  P V   VT    ++ W  P  +GGS IL Y +E  + N    Q           
Sbjct: 21259 PGPPGTPQVTA-VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 21317

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIA--PGQCRPPRVLGRPKHKEV 688
             +  + L  G  Y+ R    +  G S+ S+ S P+  L     PG+   P  L   +H  V
Sbjct: 21318 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK---PVPLNITRHT-V 21373

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRA 745
              L+W  P    G +++ Y VE  +  +   + +   +  E E TV  L     Y FRV A
Sbjct: 21374 TLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIA 21433

Query: 746   LNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY---R 801
              N  G   P S+ S+  T        K        D  +L   E+     AD+S      
Sbjct: 21434 KNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLE-ADVSGRPPPT 21492

Query: 802   LEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP 861
             +EW +D + LE    GT  + EI+     A +   L   +       +  +    P    
Sbjct: 21493 MEWSKDGKELE----GT-AKLEIK----IADFSTNLVNKDSTRRDSGAYTLTATNPGGFA 21543

Query: 862   DPVSTLCVLE-----EEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTS---- 911
               +  + VL+     E PL     +   C VL+W  P ++G ++I  Y +   +TS    
Sbjct: 21544 KHIFNVKVLDRPGPPEGPLAVTEVTSEKC-VLSWFPPLDDGGAKIDHYIVQKRETSRLAW 21602

Query: 912   ----ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPPLPPRL- 964
                   V  T + V K LL    Y  R+ A+N+ G G    S+ + A     PP PP+  
Sbjct: 21603 TNVASEVQVTKLKVTK-LLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNP 21661

Query: 965   ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKRFISIYRGPSHTYK 1016
             E       S+ + WG  +S    +E I Y ++  D+        NK+ ++  R     YK
Sbjct: 21662 EVTTITKDSMVVCWGHPDSDG-GSEIINYIVERRDKAGQRWIKCNKKTLTDLR-----YK 21715

Query: 1017  VQRLTEFTCYSFRIQAASEAG---EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEIL 1073
             V  LTE   Y FRI A + AG     P S  Y    T   P     PRV     +S  I 
Sbjct: 21716 VSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIA 21775

Query: 1074  WETVPSMKGDPV-NYILQVLVGRESEYKQVY--KGEEAT-FQISGLQTNTDYRFRVCA 1127
             W       G  +  Y++++ +  E E++ V    G +AT + I+GL  N +Y+ R+ A
Sbjct: 21776 WNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 21833



 Score =  139 bits (351), Expect = 1e-32
 Identities = 213/920 (23%), Positives = 344/920 (37%), Gaps = 85/920 (9%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE 317
             N    +EY + VK V D         V  I   +  ++W PP+        G S   +Y 
Sbjct: 19770 NSCGKKEYTIVVK-VLDTPGPPVNVTVKEISKDSAYVTWEPPI------IDGGSPIINYV 19822

Query: 318   VALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC 377
             V   D  R     +     +    + +L     Y  RV+A      G   E       S 
Sbjct: 19823 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 19882

Query: 378   APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQK 434
              P      K+   SKSS ++ WK P  D GS+I  Y++++  +E K    +++       
Sbjct: 19883 TPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK----WQRVMKSLSL 19938

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIP----QMPSAPRLVRAGITW 490
                   L     YTFR++A N+ G  G   E+      ++      +   P L       
Sbjct: 19939 QYSAKDLTEGKEYTFRVSAENENG-EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKEN 19997

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
                +   P    P   +++         D     + +  + T  V + ++S   K+ +T 
Sbjct: 19998 SNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITL 20057

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G     E  +      +PG PT P+    VT+   ++KW PPKD+GGSEI  Y+LE
Sbjct: 20058 KNVAGTK---EGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILE 20114

Query: 611   ITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTL 667
               D  S  N+W    S    T +  T L  G  Y  R    +  G  +  +S P+  R  
Sbjct: 20115 KRD--SVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHP 20172

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPEL- 726
                P    PP ++   +H  V L W  P    G  ++ Y +E  E   +  +  +   + 
Sbjct: 20173 FDVPDAPPPPNIVD-VRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIR 20231

Query: 727   --ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDG 781
               +  V  L  G  Y FRV A+N  G G  S  SE   A     PPG  K   I+ T + 
Sbjct: 20232 MRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG--KPEVINITRNS 20289

Query: 782   CVLVGWESPDSSGADISEYRLEWGE-DEESLELIYHGT--DTRFEIRDLLPAAQYCCRLQ 838
               L+  E     G  ++ Y +E  +   +S     H    +  F + DL+   +Y  R++
Sbjct: 20290 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 20349

Query: 839   AFNQAGA----GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN----W 890
             A N AGA       +E ++C+    AP       VL+    D         +VLN     
Sbjct: 20350 AKNTAGAISAPSESTETIICKDEYEAP-----TIVLDPTIKDGLTIKAGDTIVLNAISIL 20404

Query: 891   EEPCNNGSEILAYTIDLGDTSIT----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPF 946
              +P    S   A   D+  + IT       ++M  +K    +      I A N  G    
Sbjct: 20405 GKPLPKSSWSKAGK-DIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK-- 20461

Query: 947   SQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAED-----IVYTL 995
              + +K     +P  P  +E +    +   L W      G S  K++  E      +++T+
Sbjct: 20462 VEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTV 20521

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
               ED            S  +   +L +   Y FR+ A +  G+G    SE          
Sbjct: 20522 VSEDIQ----------SCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGP 20571

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATF 1110
             P   + P V+ +  N+  + W+      G  +  Y ++    +   + +  K    +   
Sbjct: 20572 PGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 20631

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             +++GLQ  + Y FRV A  R
Sbjct: 20632 KVTGLQEGSTYEFRVSAENR 20651



 Score =  136 bits (343), Expect = 1e-31
 Identities = 209/842 (24%), Positives = 320/842 (38%), Gaps = 80/842 (9%)

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWK 400
             DL     Y  RV A      G   E +  TT       P PP   K+   +K+++ L WK
Sbjct: 15974 DLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWK 16033

Query: 401   API-DNGSKITNYLLE---WDE-GKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
              P  D GS +T+Y++E   WD  G +   +RQC     +  + T   L     Y FR+ A
Sbjct: 16034 PPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 16093

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR----------------AGITWVTLQWSK 497
              N  G S  S  V        P MP +  L                   G+ + TL W K
Sbjct: 16094 VNAAGVSKPSATVGPCDCQR-PDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFK 16152

Query: 498   PEGCSPE--EVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
                  P+  E + Y   + +   D+           TCT  +   +RS    + +TA N 
Sbjct: 16153 APPKKPDNKEPVLYDTHVNKLVVDD-----------TCTLVIPQSRRSDTGLYTITAVNN 16201

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITD 613
              G +     L       RPGPP  P+    V++   ++ W PPKD+GGS+I  Y++E  +
Sbjct: 16202 LGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKRE 16258

Query: 614   GNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIA 670
              N +   W  V+       YT   L  G  Y  R    +  G  +  +S P   R L   
Sbjct: 16259 ANRKT--WVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSV 16316

Query: 671   PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT 729
             PG    P V    ++  + + W+ P  + G  V+ Y +EM +        V   P    T
Sbjct: 16317 PGAPDKPTVSSVTRN-SMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMT 16375

Query: 730   VG------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP--PGQCKAPCISCTPDG 781
             +G       L+ G+ Y+FRV A+N  G GP S  S+  TA  P  P     P ++     
Sbjct: 16376 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKS 16435

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGTD-----TRFEIRDLLPAAQYCC 835
                + W  P    G+ ++ Y +E+   EE  E    G D     T+  +  L   A Y  
Sbjct: 16436 SADLEWSPPLKDGGSKVTGYIVEY--KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKF 16493

Query: 836   RLQAFNQAGAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP 893
             R++A N AG G   E+  + +       P   L     + +  +       +  ++ + P
Sbjct: 16494 RVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPP 16553

Query: 894   CNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                   +   T+    T  T   ++  V+K+          + A NE G    +  +   
Sbjct: 16554 PTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 16613

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKW-GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPS 1012
               P P   P L       +S KL W    +       + V   +  DR       Y    
Sbjct: 16614 DVPGPVGTPFLAHNLTN-ESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTR 16672

Query: 1013  HTYKVQRLTEFTCYSFRIQAASEAGEGPF---SETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                 VQ L +   Y FRI A +  G GPF   SE        +VP   +   V ++  N+
Sbjct: 16673 QNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNT 16732

Query: 1070  CEILWETVPSMKG--DPVNYILQV-LVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRV 1125
               + W   P   G  + +NY+L+  L+G E  +K          + + GL+    Y +RV
Sbjct: 16733 VTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 16791

Query: 1126  CA 1127
              A
Sbjct: 16792 SA 16793



 Score =  136 bits (343), Expect = 1e-31
 Identities = 208/839 (24%), Positives = 321/839 (38%), Gaps = 83/839 (9%)

Query: 342   LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQ 398
             + DL     Y+ RV A+     G   EP        A E P PP+   +   SKSS  L 
Sbjct: 28509 VNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLA 28565

Query: 399   WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
             W  P  D GS+IT YLLE  + K +  + +     Q    + +L     Y FR+ A+ND 
Sbjct: 28566 WLKPDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND- 28623

Query: 458   GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCS------PEEVITY 509
               +GYS+    ++   I +    P     GIT   +T +   P          P   +T+
Sbjct: 28624 --AGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTW 28681

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
              LE    +  +      T +  T TVK+  R    ++ LT  NT G    S  +V     
Sbjct: 28682 KLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI--- 28738

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-S 628
              RPGP T P+    V++    + W  PKD GG+EI  Y++E  +  + A  W++  S   
Sbjct: 28739 GRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTA--WQLVNSSVK 28796

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
              T+   THL     Y  R    +  G S+  ES P+    IA     PP    RP+   V
Sbjct: 28797 RTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPI----IAEHPFVPPSAPTRPEVYHV 28852

Query: 689   -----HLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT--VGNLLPGTVYR 740
                   + W+ P  + G ++  Y VE  E   +   +    P LEC   V  L+ G  Y+
Sbjct: 28853 SANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQ 28912

Query: 741   FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISE 799
             FR  ALN  G    S+ S    A  P      P ++      V + W +P    G+ +  
Sbjct: 28913 FRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVG 28972

Query: 800   YRLEWGE-----DEESLELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAG--------A 845
             Y +E        D   L+  Y   +D  F +  L     Y  R+ A N AG         
Sbjct: 28973 YIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST 29032

Query: 846   GPYSELVLCQTPASAP---------DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN 896
             GP    V C+   + P           + T+    +  LDA         ++ W +   +
Sbjct: 29033 GP----VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKII-WTK--GD 29085

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
                 L   + L  T    G     V+K      + +  +   N  G    S  +K    P
Sbjct: 29086 KELDLCEKVSLQYT----GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG--PSHT 1014
              P    +L  +    +   L W     +   AE   Y ++  + ++    I  G  P+ +
Sbjct: 29142 GP--CGKLTVSRVTQEKCTLAW-SLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLS 29198

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEG--PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             Y V RL +   Y FR++A ++ G G    SE      + ++P     P           I
Sbjct: 29199 YVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIII 29258

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQV---YKGEEATFQISGLQTNTDYRFRVCA 1127
              W    S  G+ + NY++     +   + +V   Y   +   +++ L    DY+FRV A
Sbjct: 29259 QWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTA 29317



 Score =  136 bits (342), Expect = 1e-31
 Identities = 223/927 (24%), Positives = 346/927 (37%), Gaps = 101/927 (10%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKP-QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSY 316
             N S   + E++VK VQD    +  P + +NI    + L W  P+   C P +       Y
Sbjct: 28035 NASGSAKAEIKVK-VQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT------HY 28087

Query: 317   EVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTT 374
              +   +  R     I    E        L    +Y  RV A+     G    S+PV    
Sbjct: 28088 IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQI 28147

Query: 375   HSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-- 431
                 P+ P  P+ ++ + +S+TL W  P  D GS+I  Y+LE  E K     +       
Sbjct: 28148 QYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPI 28207

Query: 432   SQKHCKLTKLCPAMGYTFRLAARNDIGT---SGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
             S+   K+T L     Y F + A N  G    SG S+ + C    N P  P+  ++     
Sbjct: 28208 SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSK 28267

Query: 489   TWVTLQWSKPEGCSPEEVITYTLEI-QEDENDNLFHPKYTGE---DLTCTVKNLKRSTQY 544
             T V+L+WSKP      E+I Y +E+ + D  D  +H K   E       TV +L+   +Y
Sbjct: 28268 TTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD--WH-KVNAEACVKTRYTVTDLQAGEEY 28324

Query: 545   KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVK-------- 592
             KFR++A N  GK    EV     + DR   P   +      +H    G S++        
Sbjct: 28325 KFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGR 28384

Query: 593   ------WDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
                   W  P  N     L+  +  TD  S     E      A +YT T           
Sbjct: 28385 PTPTAVWSKPDSNLS---LRADIHTTDSFSTLTV-ENCNRNDAGKYTLT----------- 28429

Query: 647   ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEY 706
                 +  G    + ++ V      PG    P            L WD P  + G  +  Y
Sbjct: 28430 --VENNSGSKSITFTVKVLDTPGPPG----PITFKDVTRGSATLMWDAPLLDGGARIHHY 28483

Query: 707   SVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGPYSDVSEIT 761
              VE  E    + +V      +CT     V +L  G  Y FRV A+N+ G G   ++ E  
Sbjct: 28484 VVEKREASRRSWQVI---SEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPI 28540

Query: 762   TAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL-IYHGTD 819
              A   P   +   +  T     ++ W  PD   G+ I+ Y LE  +      +   H   
Sbjct: 28541 VATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ 28600

Query: 820   TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE------LVLCQTPASAPDPVSTLCVLEEE 873
               F +  L+   +Y  R++A N AG   YSE       V+ + P    +P + L  +  +
Sbjct: 28601 LTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEPQI--EPTADLTGITNQ 28655

Query: 874   PLDAYPDSPSACLVLNWEEPCNNGS----EILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
              +     SP    V     P    +    E+     D    + T   TT+ V KD +   
Sbjct: 28656 LITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV-KDSMRGD 28714

Query: 930   TYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
             + R  +   N  G   FS  +    RP P   P +E ++   +S  L WG+         
Sbjct: 28715 SGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGEPKDGGGTEI 28773

Query: 990   DIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTF 1047
                   + E     +  +      T  KV  LT++  YSFR+ + +  G   P       
Sbjct: 28774 TNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPII 28833

Query: 1048  STTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGE 1106
             +    VPP+    P V  +  N+  I WE       D  + I+   V ++     ++  E
Sbjct: 28834 AEHPFVPPSAPTRPEVYHVSANAMSIRWE---EPYHDGGSKIIGYWVEKKERNTILWVKE 28890

Query: 1107  ------EATFQISGLQTNTDYRFRVCA 1127
                   E  ++++GL    +Y+FR  A
Sbjct: 28891 NKVPCLECNYKVTGLVEGLEYQFRTYA 28917



 Score =  135 bits (341), Expect = 2e-31
 Identities = 234/959 (24%), Positives = 370/959 (38%), Gaps = 149/959 (15%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             +KP VS++   ++ ++W  P      P +G         +   K R  +  I      + 
Sbjct: 16321 DKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK-RVNRDPIKAMTLGVS 16379

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT--HSCAPECPFPPKLAHRSKSSLTL 397
               +  L   +DY  RVYA+  +  G  S P    T     AP  P  PK+   +KSS  L
Sbjct: 16380 YKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADL 16439

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLC-----PAMGYTFRL 451
             +W  P+ D GSK+T Y++E+ E     G  +   G  K  + TKL          Y FR+
Sbjct: 16440 EWSPPLKDGGSKVTGYIVEYKE----EGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRV 16495

Query: 452   AARN--DIGTSGYSQEVVCYTLGNIP---QMPSAPR---LVRAG-----ITWV------T 492
              A N   IG  G   +V+      +    Q+ ++ R   +V AG     I +V      T
Sbjct: 16496 RAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPT 16555

Query: 493   LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN 552
             + W+  E   P+E    T  I                  +  +KN +RS Q  + L A N
Sbjct: 16556 VTWNMNERTLPQEATIETTAISS----------------SMVIKNCQRSHQGVYSLLAKN 16599

Query: 553   TEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT 612
               G+    +  +     D PGP   P +   +T+    + W  P+D+GGS I  Y++E  
Sbjct: 16600 EAGER---KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKR 16656

Query: 613   DGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLS 668
             +  S+   W  V Y+ +    T   L  G  Y  R      I  G   + SE+L +R   
Sbjct: 16657 E--SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPI 16714

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP---- 724
               P +     V    K+  V L W+ P  + G E+  Y   + E   + +E +H      
Sbjct: 16715 TVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINY---VLESRLIGTEKFHKVTNDN 16770

Query: 725   --ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT---- 778
                 + TV  L  G  Y +RV A+N  G G  S  ++       P  CK      T    
Sbjct: 16771 LLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTK-------PITCKDELAPPTLHLD 16823

Query: 779   -PDGCVLVGWESPDSSG--ADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCC 835
               D   +   E+   +G  +   + ++ W +DE  +       D R  I+   PA     
Sbjct: 16824 FRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVL-----EDDRTHIK-TTPATLALE 16877

Query: 836   RLQAFNQAGAGPYSELV---------LCQT-----PASAPDPVSTLCVLEEEPLDAYPDS 881
             +++A  ++ +G Y  +V          CQ      P     PVS            + + 
Sbjct: 16878 KIKA-KRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVS------------FDEV 16924

Query: 882   PSACLVLNWEEPCNN-GSEILAYTIDLGDTSITV--------GNTTMHVMKDLLPETTYR 932
                 +V++W+ P ++ GS+I  Y I+  +    V          TT  V K LL    Y 
Sbjct: 16925 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSK-LLEGKDYI 16983

Query: 933   IRIQAINEIGAGP--FSQFIKAKTR-PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
              RI A N  G      S  +KAK R  +P  P +         S  + W    +K H   
Sbjct: 16984 FRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTW----NKPHDGG 17039

Query: 990   DIVYTLQLEDR---NKRFISIYRGPSHTY---KVQRLTEFTCYSFRIQAASEAGEG---P 1040
               +    LE R   +KR+  + + P H Y   +V  L E   Y FR+ A +E G G   P
Sbjct: 17040 KPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSP 17099

Query: 1041  FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              S+        + P     P       NS ++ W+      G  +  YI++     + E+
Sbjct: 17100 PSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEW 17159

Query: 1100  KQVYKGEEA----TFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             ++     E+     ++++GL+    Y+FRV A    ++ + E   A  P    V  R E
Sbjct: 17160 RRANHTPESCPETKYKVTGLRDGQTYKFRVLA----VNAAGESDPAHVPEPVLVKDRLE 17214



 Score =  135 bits (340), Expect = 2e-31
 Identities = 228/931 (24%), Positives = 358/931 (38%), Gaps = 118/931 (12%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
             K  V ++   +V LSW  P       H G S    Y V +  K  + K+      + L+ 
Sbjct: 23136 KITVDDVTRNSVSLSWTKP------EHDGGSKIIQYIVEMQAKHSE-KWSECARVKSLQA 23188

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL-----AHRSKSSL 395
              + +L    +Y  RV A+  + KG  S+P S      A +    P +     ++  +   
Sbjct: 23189 VITNLTQGEEYLFRVVAV--NEKGR-SDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQ 23245

Query: 396   TLQWKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              L+ + PI    K T   + W +     K+ +              + +     G  + +
Sbjct: 23246 DLKIEVPISGRPKPT---ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 23302

Query: 452   AARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYT 510
                N +G    S E+V  TL   P  P  P +        +TL W+ P      ++  Y 
Sbjct: 23303 TVANVVGQKTASIEIV--TLDK-PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYI 23359

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS--CPSEVLVCTTS 568
             ++ ++           T    T  V  LK  T+Y+FR+ A N  G+S    S+ +V    
Sbjct: 23360 VQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 23419

Query: 569   PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS----EANQWEVA 624
                PGPP  P     ++     ++W  P +NGGS ++ Y LE  + NS    + N+  + 
Sbjct: 23420 YKEPGPPGTPFATA-ISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII- 23477

Query: 625   YSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
                  T++   +L+ G  Y+ R      +  G  S+ SE    R     PG   P  V  
Sbjct: 23478 ---HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMV-- 23532

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTV 738
               K  E+ L+W  P  + G  ++ Y VE  +  D   + +   +  E + TV  L     
Sbjct: 23533 --KRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQR 23590

Query: 739   YRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWES----PD 791
             Y FRV A N  G    S  S+ T       + + P IS  P   D  V+   E+     D
Sbjct: 23591 YEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEAD 23648

Query: 792   SSGADISEYRLEW----GEDEESLELIYHGTDTR--FEIRDLL--PAAQYCCRLQAFNQA 843
               G  +    +EW     E EES       TD +    ++D +     QY   L+A N A
Sbjct: 23649 VHGKPLPT--IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI--LRASNVA 23704

Query: 844   GAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEIL 901
             G+  +   V +   P     PV    V  E+              L W  P  +G S+I 
Sbjct: 23705 GSKSFPVNVKVLDRPGPPEGPVQVTGVTSEK------------CSLTWSPPLQDGGSDIS 23752

Query: 902   AYTIDLGDTS-----ITVGNTTMHVMK--DLLPETTYRIRIQAINEIGAG-PFSQFIKAK 953
              Y ++  +TS     +       + +K   LL    Y  RI A+N+ G G P        
Sbjct: 23753 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 23812

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKR 1003
               P  LP  P  LE       S+ + W   +S    +E I Y ++  DR        NKR
Sbjct: 23813 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDG-GSEIIGYIVEKRDRSGIRWIKCNKR 23871

Query: 1004  FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSV----PPTIK 1058
              I+  R      +V  LTE   Y FR+ A + AG G P   T  +     V    PPT  
Sbjct: 23872 RITDLR-----LRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPT-- 23924

Query: 1059  APRVTQLEGNSCEILW-ETVPSMKGDPVNYILQVLVGRESEYKQV--YKGEEAT-FQISG 1114
                +     NS  + W + +     + + Y++++    E E++ V    G   T F+IS 
Sbjct: 23925 NAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK 23984

Query: 1115  LQTNTDYRFRVCACRRC-LDTSQELSGAFSP 1144
             L  + +Y+ RVCA  +  L  +  + G   P
Sbjct: 23985 LTEHQEYKIRVCALNKVGLGEATSVPGTVKP 24015



 Score =  135 bits (340), Expect = 2e-31
 Identities = 181/709 (25%), Positives = 289/709 (40%), Gaps = 74/709 (10%)

Query: 466   VVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
             +   TLG  P  P  P R        V L W  PE     E+  Y++E +E    N    
Sbjct: 27649 ITVITLGP-PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMV 27707

Query: 525   KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP--SEVLVCTTSPDRPGPPTRPLVKG 582
               +    T  V NL +  +Y+FR+ A N  G S P  S ++V       PGPP +P++  
Sbjct: 27708 CSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 27767

Query: 583   PVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTL 642
              VTS G S+ WD P  +GGSE+  + +E  + NS   Q       S  EY  T L  G  
Sbjct: 27768 -VTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLD 27826

Query: 643   YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPAS 697
             Y+ R    ++ G S  S+     TL+++P    PP   G P + +V      L+W+ P  
Sbjct: 27827 YQFRVYAENSAGLSSPSDPSKF-TLAVSPVD--PP---GTPDYIDVTRETITLKWNPPLR 27880

Query: 698   ESGCEVSEYSVEMTEPED--VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
             + G ++  YS+E  +  +  V        E + TV  L PG  Y FR+ A N    G  S
Sbjct: 27881 DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARN--AVGTIS 27938

Query: 756   DVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWESPDSS----GADISEYRLEWGEDE 808
               S+ +       +   P +   P   DG ++   ES        G  +   R+ W +D 
Sbjct: 27939 PPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP--RVTWFKDG 27996

Query: 809   ESLE--LIYHGTD----TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ-TPASAP 861
               +E  +    TD    T   +RD     +    ++A N +G+      V  Q TP    
Sbjct: 27997 VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 28056

Query: 862   DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVG----- 915
              P+    +  E+            + L W+ P N+G + I  Y I+  +TS         
Sbjct: 28057 GPIRFTNITGEK------------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIED 28104

Query: 916   --NTTMHVMKDLLPETTYRIRIQAINEIGAG-PF-SQFIKAKTR-PLPPLPPRLECAAAG 970
                   +    L+    Y+ R+ A+N+ G G P  S  + A+ +  +P  P   E +   
Sbjct: 28105 KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNIT 28164

Query: 971   PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY--RGPSHT-YKVQRLTEFTCYS 1027
               S+ L W    S   +        + E ++ R++ +   R  S T +KV  LTE   Y 
Sbjct: 28165 GNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYE 28224

Query: 1028  FRIQAASEAGEGPFSETYTFSTTKSV-----PPTIKAPRVTQLEGNSCEILWETVPSMKG 1082
             F + A + AG GP S        +       PPT+   +VT     +  + W + P   G
Sbjct: 28225 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTV--VKVTDTSKTTVSLEW-SKPVFDG 28281

Query: 1083  --DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCA 1127
               + + YI+++      ++ +V      +  + ++ LQ   +Y+FRV A
Sbjct: 28282 GMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 28330



 Score =  133 bits (335), Expect = 9e-31
 Identities = 209/942 (22%), Positives = 351/942 (37%), Gaps = 109/942 (11%)

Query: 243   GIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGL 302
             G++ T R +  +       L+   +  +   D+      P + +++  +V L+W  P   
Sbjct: 20143 GMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKT 20202

Query: 303   SCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362
                P +G    +    +L  K R  K  I       +  +  L    +Y  RV A+  + 
Sbjct: 20203 GGSPITGYHLEFKERNSLLWK-RANKTPI----RMRDFKVTGLTEGLEYEFRVMAINLAG 20257

Query: 363   KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKR 421
              G  S P          + P  P++ + +++S+TL W  P  D G K+T Y++E  +   
Sbjct: 20258 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPS 20317

Query: 422   NSGFR-------QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYT 470
              S  +       +C F       +T L     Y FR+ A+N  G     S  ++ ++C  
Sbjct: 20318 KSWMKANHVNVPECAF------TVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKD 20371

Query: 471   LGNIPQMPSAPRL-----VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPK 525
                 P +   P +     ++AG T V    S      P+   +++   ++    ++    
Sbjct: 20372 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKS--SWSKAGKDIRPSDITQIT 20429

Query: 526   YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
              T      T+K   R    ++ +TA+N  G        V  T  D PGPP  P+    V+
Sbjct: 20430 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH---VKVTVLDVPGPPG-PVEISNVS 20485

Query: 586   SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYK 644
             +   ++ W PP ++GGS I  Y+LE  +  +    W V      +  +  T L  G  Y 
Sbjct: 20486 AEKATLTWTPPLEDGGSPIKSYILEKRE--TSRLLWTVVSEDIQSCRHVATKLIQGNEYI 20543

Query: 645   LRACCISTGGHSQCSESLPVRTLSI--APGQCRPPRVLGRPKHKEVHLEWDVPASESGCE 702
              R   ++  G  +  +S PV+ +     PG    P V    K+    + W  P  + G E
Sbjct: 20544 FRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTAT-VSWKRPVDDGGSE 20602

Query: 703   VSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             ++ Y VE  E +    V +      +L C V  L  G+ Y FRV A N  G GP S+ S+
Sbjct: 20603 ITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASD 20662

Query: 760   ---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLE--------WGED 807
                +  AA PPG    P ++ T      + W  P    G +I+ Y +E        W +D
Sbjct: 20663 SVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKD 20722

Query: 808   EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL 867
                  L      T+F + DL    +Y  R+ A N AG G          PA  PD    +
Sbjct: 20723 TTGTAL----RITQFVVPDLQTKEKYNFRISAINDAGVG---------EPAVIPD----V 20765

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS--ITVGNTTMHVMKDL 925
              ++E E    +         L        G  I  +    G  +  +T     +++    
Sbjct: 20766 EIVEREMAPDFELDAELRRTL----VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRA 20821

Query: 926   LPETTYRIRIQAINEIG--------------AGPFSQFIKAKTRPLPPLPPRLECAAAGP 971
               E T    +  I E                AG  S F+  +    P     L       
Sbjct: 20822 NIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITK 20881

Query: 972   QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH--TYKVQRLTEFTCYSFR 1029
              S+ L W D       +    Y ++  +  ++  S      H  TYKV  L+E   Y FR
Sbjct: 20882 DSVTLHW-DLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 20940

Query: 1030  IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYI 1088
             + A +E G G  +ET         P    +  +  +  ++  + W       G  +  Y+
Sbjct: 20941 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 21000

Query: 1089  LQ-------------VLVGRESEYKQVYKGEEATFQISGLQT 1117
             ++              + G E   + + +GEE TFQ+  + +
Sbjct: 21001 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNS 21042



 Score =  130 bits (327), Expect = 8e-30
 Identities = 183/802 (22%), Positives = 305/802 (38%), Gaps = 105/802 (13%)

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             ++   TL W  P  D G++IT+Y++E  E  R +              +T+L     Y F
Sbjct: 29153 TQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIF 29212

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
             R+ A N  G      S+ +V      IP  P  P  V  G   + +QW+KPE     E+ 
Sbjct: 29213 RVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEIS 29272

Query: 508   TYTLEIQEDENDNL--FHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV--- 562
              Y ++ +E ++      +  Y   D    V +L     Y+FR+TA N  G S PSE    
Sbjct: 29273 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNF 29332

Query: 563   LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
             + C      PGPP+ P V    T H  S+ W  P  +GG++I+ Y+LE+ +   + +QW 
Sbjct: 29333 ISCREPSYTPGPPSAPRVVD-TTKHSISLAWTKPMYDGGTDIVGYVLEMQE--KDTDQWY 29389

Query: 623   VAYSGSA---TEYTFTHLKPGTLYKLRACCISTGGHSQCSESL----PVRTLSIAPGQCR 675
               ++ +    TE+T   LK G  Y  R   ++  G S+ SES+    PV  + I      
Sbjct: 29390 RVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEI------ 29443

Query: 676   PPRVLGRPKHKEVHLEWDVP----ASESG-----CEVSEYSVEMTEPEDVASEVYHGPEL 726
             P   L     K V +          S SG        S+  +++     + +   +   +
Sbjct: 29444 PDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI 29503

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V     G   ++ + A N  G       + +      PG C +  +       V + 
Sbjct: 29504 VDKVNRYDAG---KYTIEAENQSGK---KSATVLVKVYDTPGPCPSVKVKEVSRDSVTIT 29557

Query: 787   WESPD-SSGADISEYRLEWGEDEESLELIYHGTD----TRFEIRDLLPAAQYCCRLQAFN 841
             WE P    GA ++ Y +E  + E ++      T     T + I  L+    Y  R+   N
Sbjct: 29558 WEIPTIDGGAPVNNYIVE--KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPEN 29615

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEI 900
               G G   E       +  P   + L V+         D   + + L WE+P  + GS +
Sbjct: 29616 IYGIGEPCETSDAVLVSEVPLVPAKLEVV---------DVTKSTVTLAWEKPLYDGGSRL 29666

Query: 901   LAYTIDLGDTS-------ITVGNTTM-HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA 952
               Y ++            +T+  T + H +  L     Y  RI+A NE G     + + A
Sbjct: 29667 TGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTA 29726

Query: 953   KT----RPLPPL----------------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV 992
              T    R LP +                P  L    AG       W  + SK   +E + 
Sbjct: 29727 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 29786

Query: 993   YTL--QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
                  ++     R  +I     +T +++ +T  T  + ++    + G             
Sbjct: 29787 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG------------- 29833

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG-EEA 1108
                PPT    ++ +++  S  I WE      G P++ Y+++        +  V +    +
Sbjct: 29834 ---PPTGPI-KIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS 29889

Query: 1109  TFQISGLQTNTDYRFRVCACRR 1130
             TF+ + L    +Y FRV A  R
Sbjct: 29890 TFKFTRLTEGNEYVFRVAATNR 29911



 Score =  130 bits (326), Expect = 1e-29
 Identities = 226/960 (23%), Positives = 367/960 (38%), Gaps = 129/960 (13%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKG-RDGKYKIIYSGEELE 339
             KP V++I   A  +SW  P      P +G    Y     ++ K  R  K  I     +L+
Sbjct: 17709 KPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREVTGKWVRVNKTPIA----DLK 17761

Query: 340   CNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLT 396
               +  L     Y  RV+A      S     S+P+        P  P  PKL  +S+ +  
Sbjct: 17762 FRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD 17821

Query: 397   LQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGY 447
             L W  P+ D GS I  Y++E        W+   ++   RQC F      ++  L     Y
Sbjct: 17822 LVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAF------RVPGLIEGNEY 17875

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---------VRAGITWVTLQWSKP 498
              FR+ A N +G  G  +E+    +      P    L         VR G T   L   K 
Sbjct: 17876 RFRIKAANIVG-EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKG 17934

Query: 499   EGCSPEEVITYTLE----IQEDENDNLFHPKYTGEDLT---CTVKNLKRSTQYKFRLTAS 551
                 PE  IT+T E    ++E   D +       +DL      +K   R+   K+ ++A 
Sbjct: 17935 R---PEPDITWTKEGKVLVREKRVDLI-------QDLPRVELQIKEAVRADHGKYIISAK 17984

Query: 552   NTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEI 611
             N+ G +  S ++      DRPGP     V   VT    ++ W+ P DNGGSEI  +++E 
Sbjct: 17985 NSSGHAQGSAIVNVL---DRPGPCQNLKVTN-VTKENCTISWENPLDNGGSEITNFIVEY 18040

Query: 612   TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES-LPVRTLSIA 670
                N +   W +  S         +L     Y  R C  +  G     E+  P+  ++  
Sbjct: 18041 RKPNQKG--WSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPI 18098

Query: 671   PGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHG--PEL 726
                  P  +    K K  V+L+W  P  + G     Y VE   +  D    V+ G   E 
Sbjct: 18099 DRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 18158

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V   +   +Y FRV+  N+GG   +    E+          + P +     G + V 
Sbjct: 18159 HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKE----DLQKPVLDLKLSGVLTVK 18214

Query: 787   WESPDSSGADISEY---RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                     A +       + W +D+++ +L       R +I     ++++   L    ++
Sbjct: 18215 AGDTIRLEAGVRGKPFPEVAWTKDKDATDLT---RSPRVKIDTRADSSKF--SLTKAKRS 18269

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEE-------EPLDAYPDSPSACLVLNWEEPCNN 896
               G Y  +V     A +    +T+ VL++       + +D   D  + C    W+ P ++
Sbjct: 18270 DGGKY--VVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVC----WDPPEDD 18323

Query: 897   GS-EILAYTIDLGDTSITVGNTTMHVMKDLLPETT---------YRIRIQAINEIGAGP- 945
             G  EI  Y ++  +T   V +T    +  L P TT         Y  R++A N+IG GP 
Sbjct: 18324 GGCEIQNYILEKCETKRMVWSTYSATV--LTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 18381

Query: 946   -FSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
               S+ + AKT   +P  P PP  E      + + + W         +    +  + E  +
Sbjct: 18382 TESKPVIAKTKYDKPGRPDPP--EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 18439

Query: 1002  KRFISIYRG--PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV-----P 1054
              R++ + +   P    KVQ L     Y FR++A +E G G  S        K       P
Sbjct: 18440 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGP 18499

Query: 1055  PTIKAPRVTQLEGNSCEILWETVPSMKGDP-VNYILQVL-----VGRESEYKQVYKGEEA 1108
             PT    RV     +S  + W       G P + Y++++         +  +K+     + 
Sbjct: 18500 PT--NFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 18557

Query: 1109  T---FQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSL 1164
                 F ++ L  N +Y FRVCA  +  +    EL  A  P    +L+  E+ L   M  L
Sbjct: 18558 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASMRKL 18615



 Score =  129 bits (325), Expect = 1e-29
 Identities = 204/922 (22%), Positives = 356/922 (38%), Gaps = 76/922 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S     +V+ I   +V ++W PP+        G S   +Y V   +  R     
Sbjct: 23029 RVLDTPSPPVNLKVTEITKDSVSITWEPPL------LDGGSKIKNYIVEKREATRKSYAA 23082

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             ++ +  +    +  L+    Y+ RV A      G  ++       +  P+ P    +   
Sbjct: 23083 VVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDV 23142

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W  P  D GSKI  Y++E  + K +  + +C         +T L     Y F
Sbjct: 23143 TRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLF 23201

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVI 507
             R+ A N+ G S      V     ++   P       +    V   L+   P    P+  I
Sbjct: 23202 RVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI 23261

Query: 508   TYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             T+T +    +     +   + +  T ++K   +    ++ +T +N  G+   S  +V   
Sbjct: 23262 TWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL- 23320

Query: 568   SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG 627
               D+P PP  P+    V++   ++ W+PP   GG +I  Y+++  D  +    W+V  + 
Sbjct: 23321 --DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD--TTTTVWDVVSAT 23376

Query: 628   SA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP--- 683
              A T    T LK GT Y+ R    +  G S   ES P+    +A    + P   G P   
Sbjct: 23377 VARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI----VAQYPYKEPGPPGTPFAT 23432

Query: 684   --KHKEVHLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPG 736
                   + ++W  P +  G  V  Y +E  E        V   + H  + +    NL  G
Sbjct: 23433 AISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ--NLEEG 23490

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
               Y FRV A N  G G  S  SE   A  P      P         + + W  P    G+
Sbjct: 23491 IEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGS 23550

Query: 796   DISEYRLEWGE--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELV 852
              I+ Y +E  +  D   ++  +    +T+F +  L    +Y  R+ A N AGA       
Sbjct: 23551 MITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGA------- 23603

Query: 853   LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE----EPCNNGSEILAYTIDLG 908
                 P+ +  P++    +E   +   P      +V   E    E   +G  +       G
Sbjct: 23604 -ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 23662

Query: 909   DTSI------TVGNT---TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
             D  I       + NT    + ++KD +     +  ++A N  G+  F   +K   RP PP
Sbjct: 23663 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 23722

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLEDRNKRFISIYRGP--SHTYK 1016
               P ++      +   L W  S        DI  Y ++  + ++   ++      +++ K
Sbjct: 23723 EGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLK 23779

Query: 1017  VQRLTEFTCYSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
             V +L E   Y FRI A ++ G G   E+          +P   K+  VT +  +S  + W
Sbjct: 23780 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 23839

Query: 1075  ETVPSMKG-DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCACRRC 1131
                 S  G + + YI++        + +  K    +   +++GL  + +Y FRV A    
Sbjct: 23840 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA---- 23895

Query: 1132  LDTSQELSGAFSPSAAFVLQRS 1153
                 +  +G   PS A V  ++
Sbjct: 23896 ----ENAAGVGEPSPATVYYKA 23913



 Score =  129 bits (323), Expect = 2e-29
 Identities = 206/920 (22%), Positives = 363/920 (39%), Gaps = 81/920 (8%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EELEC 340
             P+V+ I   ++ + W+ P+       SG      Y +   DK   G +K++     +   
Sbjct: 27072 PEVTKITKNSMTVVWSRPIADGGSDISG------YFLEKRDKKSLGWFKVLKETIRDTRQ 27125

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTL 397
              +  L   +DY  RV A+  + +G  SEP  F   +   + P PP   ++A  +KSS+TL
Sbjct: 27126 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITL 27185

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
              W  P+ D GS +T Y++E  +G+          G  +  +  ++ L P + Y FR++A 
Sbjct: 27186 GWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAV 27245

Query: 455   NDIGTSG---YSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVITY 509
             N  G       ++ V    +   P++     L  + I      +Q   P    P   +T+
Sbjct: 27246 NCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTW 27305

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
               + +   +D  +  + T      T+  + R+   K+ LT  N  G+  P    V     
Sbjct: 27306 RKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE--PKSSTVSVKVL 27363

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV-AYSGS 628
             D P    +  VK  V+    ++ WDPP  +GGS I+ Y++E  D       W V ++  S
Sbjct: 27364 DTPAACQKLQVKH-VSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRT--WSVVSHKCS 27420

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQ-CSESLPVRTLSIAPGQCRPPRVLGRPKHKE 687
             +T +    L   T +  R    +  G  + C  + PV+   + P   R   +    K   
Sbjct: 27421 STSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEV-PAPIRDLSMKDSTK-TS 27478

Query: 688   VHLEWDVPASESGCEVSEYSVEMT-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V L W  P  + G  ++EY VE   + E   S        E  V  L   +V  FRV A 
Sbjct: 27479 VILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAK 27538

Query: 747   NDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGE 806
             N+ G      +  IT         K   I+   D   + G +     G ++       G+
Sbjct: 27539 NEKGLSDPVTIGPITV--------KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGK 27590

Query: 807   DEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPV 864
              + S+  +  G   +    +R      +    ++   +   G Y+ ++L         P+
Sbjct: 27591 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT-VILDNAVCRIAVPI 27649

Query: 865   STLCV----LEEEPLDAYPDSPSACLVLNWEEPCNNGS-EILAYTIDLGDTSIT------ 913
             + + +      + P+  + +  +  ++L+W+ P +NG  EI  Y+I+  +TS T      
Sbjct: 27650 TVITLGPPSKPKGPI-RFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVC 27708

Query: 914   --VGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTR---PLPPLPPRLEC 966
               V  TT  V  +L+ +  Y+ R++A N  G      S  I AK +   P PP  P +  
Sbjct: 27709 SSVARTTFKV-PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 27767

Query: 967   AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEF 1023
               +    + L W D+      +E   + ++ ++RN    + ++        Y+   L E 
Sbjct: 27768 VTS--DGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 27824

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
               Y FR+ A + AG    S+   F+   S       P    +   +  + W   P   G 
Sbjct: 27825 LDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP-PLRDGG 27883

Query: 1084  P--VNYILQVLVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
                V Y ++   G E   +  +    E  + ++GL     Y FR+ A        +   G
Sbjct: 27884 SKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA--------RNAVG 27935

Query: 1141  AFSPSAAFVLQRSEVMLTGD 1160
               SP +    Q S +++T D
Sbjct: 27936 TISPPS----QSSGIIMTRD 27951



 Score =  128 bits (322), Expect = 3e-29
 Identities = 231/931 (24%), Positives = 352/931 (37%), Gaps = 155/931 (16%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+ SNI   ++ L+WA P         G S    Y +   +K      K+I      E  
Sbjct: 28158 PEPSNITGNSITLTWARPES------DGGSEIQQYILERREKKSTRWVKVISKRPISETR 28211

Query: 342   LK--DLRPATDYHVRVYAMYNSVKG---------SCSEPVSFTTHSCAPECPFPPKLAHR 390
              K   L    +Y   V A   +  G          C EPV+       P  P   K+   
Sbjct: 28212 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVN------PPGPPTVVKVTDT 28265

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYT 448
             SK++++L+W  P+ D G +I  Y++E  +       +       K    +T L     Y 
Sbjct: 28266 SKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYK 28325

Query: 449   FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGIT-------- 489
             FR++A N  G  G S EV   T+  + ++ +AP L           VRAG +        
Sbjct: 28326 FRVSAINGAG-KGDSCEVTG-TIKAVDRL-TAPELDIDANFKQTHVVRAGASIRLFIAYQ 28382

Query: 490   ---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKF 546
                  T  WSKP+           L ++ D +        T    T TV+N  R+   K+
Sbjct: 28383 GRPTPTAVWSKPDS---------NLSLRADIHT-------TDSFSTLTVENCNRNDAGKY 28426

Query: 547   RLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
              LT  N  G KS    V V     D PGPP  P+    VT    ++ WD P  +GG+ I 
Sbjct: 28427 TLTVENNSGSKSITFTVKVL----DTPGPP-GPITFKDVTRGSATLMWDAPLLDGGARIH 28481

Query: 606   KYLLEITDGNSEANQWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLP 663
              Y++E  + +  +  W+V  S   T   F    L  G  Y  R   ++  G     E   
Sbjct: 28482 HYVVEKREASRRS--WQV-ISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYG---VGEPYE 28535

Query: 664   VRTLSIAPGQCRPPR---VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASE 719
             +    +A  Q  PPR   V+   K   V L W  P  + G  ++ Y +EM +   D   E
Sbjct: 28536 MPEPIVATEQPAPPRRLDVVDTSKSSAV-LAWLKPDHDGGSRITGYLLEMRQKGSDFWVE 28594

Query: 720   VYHGPELECTVGNLLPGTVYRFRVRALNDGGYG-----------------PYSDVSEITT 762
               H  +L  TV  L+  T Y FRV+A ND GY                  P +D++ IT 
Sbjct: 28595 AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN 28654

Query: 763   -----AAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHG 817
                   AG P     P IS  P     V W+        + E RL   ++ + + +    
Sbjct: 28655 QLITCKAGSPFTIDVP-ISGRP--APKVTWK--------LEEMRL---KETDRVSITTTK 28700

Query: 818   TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDA 877
               T   ++D +        L   N AG   +S  V+       P PV+        P++ 
Sbjct: 28701 DRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV---IGRPGPVT-------GPIEV 28750

Query: 878   YPDSPSACLVLNWEEPCN-NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT------ 930
                S  +C VL+W EP +  G+EI  Y ++  ++  T        +K    + T      
Sbjct: 28751 SSVSAESC-VLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYM 28809

Query: 931   -YRIRIQAINEIGAG-PFSQFIKAKTRPL--PPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              Y  R+ + N  G   P          P   P  P R E       ++ ++W +      
Sbjct: 28810 EYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRW-EEPYHDG 28868

Query: 987   AAEDIVYTLQLEDRNK-RFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              ++ I Y ++ ++RN   ++   + P     YKV  L E   Y FR  A + AG    SE
Sbjct: 28869 GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASE 28928

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQ----VLVGRES 1097
                    ++       P VT +  ++  ++W + P+  G    V YI++      VG   
Sbjct: 28929 ASRPIMAQNPVDAPGRPEVTDVTRSTVSLIW-SAPAYDGGSKVVGYIIERKPVSEVGDGR 28987

Query: 1098  EYKQVYK-GEEATFQISGLQTNTDYRFRVCA 1127
               K  Y    +  F ++ L     Y FRV A
Sbjct: 28988 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLA 29018



 Score =  128 bits (321), Expect = 4e-29
 Identities = 204/914 (22%), Positives = 339/914 (37%), Gaps = 102/914 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             +V D  +  +K QV ++    V L W PP+        G S   +Y +   D  +     
Sbjct: 27361 KVLDTPAACQKLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWSV 27414

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---L 387
             + +        L DL   T +  RV A  N +     EP   T    A E P P +   +
Sbjct: 27415 VSHKCSSTSFKLIDLSEKTPFFFRVLAE-NEI--GIGEPCETTEPVKAAEVPAPIRDLSM 27471

Query: 388   AHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
                +K+S+ L W  P  D GS IT Y++E  +GK    +           ++++L     
Sbjct: 27472 KDSTKTSVILSWTKPDFDGGSVITEYVVE-RKGKGEQTWSHAGISKTCEIEVSQLKEQSV 27530

Query: 447   YTFRLAARNDIGTSG-------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPE 499
               FR+ A+N+ G S          +E++     ++  +P A   VR G     +    P 
Sbjct: 27531 LEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHN---VHLELPY 27587

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
                P+  I++  +    +         T   +T ++KN K+    K+ +   N     C 
Sbjct: 27588 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV---CR 27644

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V +   +   P  P  P+    + +    + WD P+DNGG EI  Y +E  +  S+ N
Sbjct: 27645 IAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE-TSQTN 27703

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
                V  S + T +   +L     Y+ R    +  G SQ      V ++ +A  Q R P  
Sbjct: 27704 WKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL----VSSIIVAKHQFRIPGP 27759

Query: 680   LGRPKHKEV-----HLEWDVPASESGCEVSEYSVEMTEP-----EDVASEVYHGPELECT 729
              G+P    V      L WD P  + G EV+ + VE  E      + V +    G E   T
Sbjct: 27760 PGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRAT 27819

Query: 730   VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES 789
                L+ G  Y+FRV A N  G    SD S+ T A  P      P         + + W  
Sbjct: 27820 --GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP 27877

Query: 790   P-DSSGADISEYRLEWGEDEESLEL--IYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAG 846
             P    G+ I  Y +E  +  E          ++ ++ +  L P  +Y  R+ A N  G  
Sbjct: 27878 PLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT- 27936

Query: 847   PYSELVLCQTPASAPDPVSTLCVLEEE---PLDAYPDSPSACLVLNWEEPC--------- 894
                         S P   S + +  +E   P+  +       L++   E           
Sbjct: 27937 -----------ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGR 27985

Query: 895   --------NNGSEI-----LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEI 941
                      +G EI     +  T  LG TS+ V        +D   +      ++A N  
Sbjct: 27986 PVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFV--------RDATRDHRGVYTVEAKNAS 28037

Query: 942   GAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
             G+      +K +  P   + P       G +     W D+      A    Y ++  + +
Sbjct: 28038 GSAKAEIKVKVQDTPGKVVGPIRFTNITGEK--MTLWWDAPLNDGCAPITHYIIEKRETS 28095

Query: 1002  KRFISIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PF-SETYTFSTTKSVPPTI 1057
             +   ++   +  + +Y   +L     Y FR+ A ++ G G P  S+        +VP   
Sbjct: 28096 RLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAP 28155

Query: 1058  KAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG---EEATFQIS 1113
               P  + + GNS  + W    S  G  +  YIL+    + + + +V       E  F+++
Sbjct: 28156 GIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVT 28215

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y F V A
Sbjct: 28216 GLTEGNEYEFHVMA 28229



 Score =  126 bits (317), Expect = 1e-28
 Identities = 220/925 (23%), Positives = 347/925 (37%), Gaps = 120/925 (12%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             + S+I   +  L+W PP         G +    Y +   + GR     ++    +L   +
Sbjct: 14487 KASDITKSSCKLTWEPP------EFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTV 14540

Query: 343   KDLRPATDYHVRVYAMYNSVKGS----CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             KDL P  +Y  RV A+ N V G        PV        P+ P   ++ + +  ++T+ 
Sbjct: 14541 KDLIPNGEYFFRVKAV-NKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTIT 14599

Query: 399   WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG------YTFRL 451
             WK P+ D GSKI  Y++E    K    +++C     +H        A G      Y FR+
Sbjct: 14600 WKPPLYDGGSKIMGYIIE-KIAKGEERWKRC----NEHLVPILTYTAKGLEEGKEYQFRV 14654

Query: 452   AARNDIGTSGYSQ--------------EVVCYTLGNIPQMPS-APRLVRAGITWVTLQWS 496
              A N  G S  S+              +V+  T   + +    A     +G  + T+ W 
Sbjct: 14655 RAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWI 14714

Query: 497   KPEG-CSPEEVITYTL--------EIQEDE------NDNLFHPKYTGEDLTCTVKNLKRS 541
             K E    PEE+             E+QE+E         L        +    V++  R 
Sbjct: 14715 KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRP 14774

Query: 542   TQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
                 + +   N  G    P  V V     D PGPP    V   +       KW+PP D+G
Sbjct: 14775 DHGLYMIKVENDHGIAKAPCTVSVL----DTPGPPIN-FVFEDIRKTSVLCKWEPPLDDG 14829

Query: 601   GSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
             GSEI+ Y LE  D     ++W V  S     +Y+ T L  G  Y  R    +  G     
Sbjct: 14830 GSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPC 14889

Query: 660   ESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYSVEMTEPE 714
              S P+    +A     PP    +P  ++V      ++W+ P  ++G  +  Y +E  E  
Sbjct: 14890 VSKPL----VAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEP-KDNGSPILGYWLEKREVN 14944

Query: 715   DVA-SEVYHG--PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPG 768
                 S V       L+  V  LL G  Y FRV A N  G G +S  S+  TA     PPG
Sbjct: 14945 STHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPG 15004

Query: 769   QCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL--------EWGEDEESLELIYHGTD 819
                 P ++ T    + + WE P  + G +I  Y +        EW    E +  +     
Sbjct: 15005 P-PIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKV----- 15058

Query: 820   TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPASAPDPVSTLCVLEEEPLDA 877
              ++ ++++   A Y  R+ A N AG GP  E   V    P   P     + V     + A
Sbjct: 15059 RQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMA 15118

Query: 878   YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTY 931
                     +V     P         +T + G+          VG  +  ++KD L +   
Sbjct: 15119 GKTLRIPAVVTGRPVPTK------VWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHG 15172

Query: 932   RIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
             R  I A N  G+   +  ++    P P L   L+      +   L W D       +E  
Sbjct: 15173 RYVITATNSCGSKFAAARVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPED-DGGSEIT 15229

Query: 992   VYTLQLEDRNKRFISIYRGPSHTYK----VQRLTEFTCYSFRIQAASEAGEGPFSETYTF 1047
              + ++ +D     +  +R P  T +    +  L E   Y FR+ A ++ G GP  E    
Sbjct: 15230 GFIIERKDAK---MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPI 15286

Query: 1048  STTKSVPPTIKAPRVTQLEGNSCEIL--WETVPSMKGDPV-NYILQVLVGRESEYKQVYK 1104
                  + P     R+T  E     I   W+   S  G P+  YI++     + ++++V K
Sbjct: 15287 LAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNK 15346

Query: 1105  G--EEATFQISGLQTNTDYRFRVCA 1127
                   +F +  L  +  Y FRV A
Sbjct: 15347 RLCPTTSFLVENLDEHQMYEFRVKA 15371



 Score =  126 bits (316), Expect = 1e-28
 Identities = 195/799 (24%), Positives = 300/799 (37%), Gaps = 105/799 (13%)

Query: 391   SKSSLTLQWKAPIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +K  + + WK P+D+ GSKITNY++E  E  ++         ++  CK++KL     Y F
Sbjct: 16925 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIF 16984

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKP-EGCSPEEV 506
             R+ A N  G S    S  +       +P  P  P +         + W+KP +G  P  +
Sbjct: 16985 RIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP--I 17042

Query: 507   ITYTLEIQEDEN-------DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG---K 556
               Y LE +E  +        +  HP YT       V +L    QY+FR++A N  G    
Sbjct: 17043 TNYILEKRETMSKRWARVTKDPIHP-YT----KFRVPDLLEGCQYEFRVSAENEIGIGDP 17097

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
             S PS+ +       +P PP  P      T +   + W PP+ +GGS+IL Y++E      
Sbjct: 17098 SPPSKPVFAKDPIAKPSPPVNPEAI-DTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 17156

Query: 617   EANQWEVA----YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPG 672
             E  +W  A     S   T+Y  T L+ G  YK R   ++  G    S+   V    +   
Sbjct: 17157 E--EWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKD 17211

Query: 673   QCRPPRV-----LGRPKHKEVHLEWDVPASESGC---EVSEYSVEMTEPEDVASEVYH-G 723
             +  PP +     + R +H +V     + A   G    +V+    +   P     +V   G
Sbjct: 17212 RLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVG 17271

Query: 724   PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCV 783
              +LE        G +Y   V   N  G    S    +    GPP   +   I    D C 
Sbjct: 17272 SKLEIRNAAHEDGGIYSLTVE--NPAGSKTVSVKVLVLDKPGPPRDLEVSEI--RKDSCY 17327

Query: 784   LVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFN 841
             L   E  D  G+ I+ Y +E  +   +       T  +     + L    QY  R+ A N
Sbjct: 17328 LTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAEN 17387

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEE--EPLDA-YPDSPSACLVLNWEEP-CNNG 897
             Q G GP+ E          P P+  L  L     P D  + D     + L W +P  + G
Sbjct: 17388 QYGRGPFVE---------TPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGG 17438

Query: 898   SEILAYTIDLGDTSI-------TVGNTTMHVMKDLLPETTYRIRIQAINEIGAG-PFSQF 949
             S I  Y ++  +          TV N    V+  L    TYR R++A N +G G P +  
Sbjct: 17439 SPITGYLVEYQEEGTQDWIKFKTVTNLEC-VVTGLQQGKTYRFRVKAENIVGLGLPDTTI 17497

Query: 950   -IKAKTRPLPP-----------------LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
              I+ + + +PP                    R      G      KW    S+    E  
Sbjct: 17498 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEH- 17556

Query: 992   VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK 1051
              YT++ ++            S    ++         ++I  ++ AG           T  
Sbjct: 17557 -YTVETDNF-----------SSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVL 17601

Query: 1052  SVPPTIKAP-RVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
              VP     P  +  +      I W+      G PV NYI++    R+  +  V  G   T
Sbjct: 17602 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 17661

Query: 1110  -FQISGLQTNTDYRFRVCA 1127
               +I  LQ   +Y FRV A
Sbjct: 17662 KLKIPHLQKGCEYVFRVRA 17680



 Score =  125 bits (315), Expect = 2e-28
 Identities = 151/597 (25%), Positives = 233/597 (39%), Gaps = 48/597 (8%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS I+  +  L+W  P+        G S   +Y V   D        +  + ++     
Sbjct: 17317 EVSEIRKDSCYLTWKEPLD------DGGSVITNYVVERRDVASAQWSPLSATSKKKSHFA 17370

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR---SKSSLTLQW 399
             K L     Y  RV A     +G   E             P PPK  H     K+ ++L W
Sbjct: 17371 KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVW 17430

Query: 400   KAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
               P  D GS IT YL+E+ E +    + +    +   C +T L     Y FR+ A N +G
Sbjct: 17431 NKPDRDGGSPITGYLVEYQE-EGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVG 17489

Query: 459   TS--GYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCSPEEVITYTLEIQ 514
                   +  + C      P +    +L+   +     T+++       P     +T +  
Sbjct: 17490 LGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGS 17549

Query: 515   EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGP 574
             E + D  +  +        T+KN  R    ++++T SN  G      V V  T  D PGP
Sbjct: 17550 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKT---VAVHLTVLDVPGP 17606

Query: 575   PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA-TEYT 633
             PT P+    VT    ++ W PPKD+GGS ++ Y++E  D  +  + W V  SGS+ T+  
Sbjct: 17607 PTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQD--TRKDTWGVVSSGSSKTKLK 17664

Query: 634   FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV----- 688
               HL+ G  Y  R    +  G     +S P    ++A  +  PP   G+P   ++     
Sbjct: 17665 IPHLQKGCEYVFRVRAENKIGVGPPLDSTP----TVAKHKFSPPSPPGKPVVTDITENAA 17720

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP--ELECTVGNLLPGTVYRFRVRAL 746
              + W +P S+ G  ++ Y +E  E       V   P  +L+  V  L  G  Y FRV A 
Sbjct: 17721 TVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 17780

Query: 747   NDGGY---GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRL 802
             N  G     P SD  +      PPG    P +         + W  P    G+ I  Y +
Sbjct: 17781 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVV 17840

Query: 803   E--------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL 851
             E        W    +  ELI       F +  L+   +Y  R++A N  G G   EL
Sbjct: 17841 ECQKPGTAQWNRINKD-ELI---RQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 17893



 Score =  125 bits (313), Expect = 3e-28
 Identities = 187/810 (23%), Positives = 304/810 (37%), Gaps = 46/810 (5%)

Query: 351   YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKI 409
             + VR    Y       SEP+        P  P  P+     K  + +QW  P  D G++I
Sbjct: 29212 FRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEI 29271

Query: 410   TNYLLEWDEGK--RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQE-- 465
             +NYL++  E K  R +   + +       K+T L     Y FR+ A N  G S  S+   
Sbjct: 29272 SNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASN 29331

Query: 466   -VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLF-- 522
              + C      P  PSAPR+V      ++L W+KP      +++ Y LE+QE + D  +  
Sbjct: 29332 FISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRV 29391

Query: 523   HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPL--- 579
             H   T  +   TV +LK   +Y FR+ A N +G S  SE +      +R   P   L   
Sbjct: 29392 HTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADD 29451

Query: 580   VKGPVTSH-GFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
             +K  VT   G S++           ++ +  +  D  S A         +   Y+   + 
Sbjct: 29452 LKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA------IIDTTESYSLLIVD 29505

Query: 639   PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
                 Y      I     S    +  +  +   PG C P   +       V + W++P  +
Sbjct: 29506 KVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPC-PSVKVKEVSRDSVTITWEIPTID 29564

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGP 753
              G  V+ Y VE  E    A   +     +C+     +  L+ GT+Y FRV   N  G G 
Sbjct: 29565 GGAPVNNYIVEKRE---AAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE 29621

Query: 754   YSDVSE-ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEW---GEDE 808
               + S+ +  +  P    K   +  T    V + WE P    G+ ++ Y LE    G + 
Sbjct: 29622 PCETSDAVLVSEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGTER 29680

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPD-PVSTL 867
                 +    T     +  L    QY  R++A N+ G     E V   T       P   L
Sbjct: 29681 WMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDL 29740

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLP 927
               + ++ +      P   ++     P    S   A +       +TV  T   V K  + 
Sbjct: 29741 STMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTV-ETHTKVAKLTIR 29799

Query: 928   ETTYRIRIQAINEIG--AGPFSQFIKA--KTRPLPPLPPRLECAAAGPQSLKLKWGDSNS 983
             ETT R   +   E+    G  S+ IK     +P PP  P ++       S+ + W     
Sbjct: 29800 ETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEIDATSITISWEPPEL 29858

Query: 984   KTHAAEDIVYTLQLEDRNKRFISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPF- 1041
                A        Q +     ++ +    +  T+K  RLTE   Y FR+ A +  G G + 
Sbjct: 29859 DGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYL 29918

Query: 1042  -SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              SE     ++  +P   +  ++  +  +   + W       G  V  YI++    R   +
Sbjct: 29919 QSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 29978

Query: 1100  KQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
              +V K       ++ +GL    +Y  RV A
Sbjct: 29979 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTA 30008



 Score =  122 bits (307), Expect = 2e-27
 Identities = 153/606 (25%), Positives = 230/606 (37%), Gaps = 68/606 (11%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             + P PP+   +    K S  L W+ PI D G+K+ NY+++  E  R +        S+  
Sbjct: 24114 DTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTS 24173

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW 495
              K+  L     Y FR+ A N+ G     + V        P  P    L     T  +L W
Sbjct: 24174 FKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMW 24233

Query: 496   SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
              KPE      V+ Y +E+Q    +         E   C   V  L    +Y+FR+ A N 
Sbjct: 24234 EKPEHDGGSRVLGYVVEMQPKGTEKW---SIVAESKVCNAVVTGLSSGQEYQFRVKAYNE 24290

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVKWDPPKDNGGSEILKYLL 609
             +GKS P  + V   + D      +P +K P  ++    G  +K + P        + +  
Sbjct: 24291 KGKSDPRVLGVPVIAKDLT---IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISW-- 24345

Query: 610   EITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS-TGGHSQCSESLPVRTLS 668
              + DG        V    +AT  T  H+K G         ++ T      +E+L V  L 
Sbjct: 24346 -VKDGEPLKQTTRVNVEETATS-TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 24403

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC 728
               PG    P          V + W+ PA   GC++S Y VE  +       +        
Sbjct: 24404 -KPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVART 24462

Query: 729   TVG--NLLPGTVYRFRVRALNDGGYGPYSDVSEITTA-----AGPPGQCKAPCISCTPDG 781
             T+    L  GT Y+FR+ A N  G     D   +         GPPG    P ++     
Sbjct: 24463 TIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPG---TPFVTSISKD 24519

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRL 837
              +LV W  P +  G  I  Y LE  E    L +  + T   DT+F+   L    +Y  ++
Sbjct: 24520 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 24579

Query: 838   QAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV------LNWE 891
              A N  G G              P  VS  C +  +P D  P  P A ++      L W+
Sbjct: 24580 SAENIVGIG-------------KPSKVSE-CFVARDPCDP-PGRPEAIVITRNNVTLKWK 24624

Query: 892   EPC-NNGSEILAYTIDLGD--------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
             +P  + GS+I  Y ++  D         S T    T   +  L+ +  Y  R+ A N   
Sbjct: 24625 KPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARN--A 24682

Query: 943   AGPFSQ 948
             AG FS+
Sbjct: 24683 AGNFSE 24688



 Score =  121 bits (304), Expect = 3e-27
 Identities = 199/899 (22%), Positives = 328/899 (36%), Gaps = 99/899 (11%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+ + A    L+W PP+        G +    Y +   +  R    ++    + L   +
Sbjct: 24810 KVTGVTAEKCYLAWNPPL------QDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKV 24863

Query: 343   KDLRPATDYHVRVYAM--YNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L P  +Y  RV A+  Y   +   S PV+       P  P  P+++  +K S+ + W 
Sbjct: 24864 TKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWA 24923

Query: 401   APIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPAMGYTFRLAARNDI 457
              P+D+ G++I  Y+LE    K    + +C   +    +L  T L     Y FR+AA N  
Sbjct: 24924 RPVDDGGTEIEGYILE-KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAA 24982

Query: 458   GTSGYSQEVVCYTLGNI---PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
             G    S+  V Y   +    P  PS P++     + V+L WSKP       V  Y +E++
Sbjct: 24983 GVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVK 25042

Query: 515   EDEND--NLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
             E   D      P    +    TV  LK +T+Y FR+ A N+EG   P+ +     + +R 
Sbjct: 25043 EAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERI 25102

Query: 573   GPPTRPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
              PP   L   ++  V                 S  L+  + I        +WE A  G  
Sbjct: 25103 EPPEIELDADLRKVVVLR-------------ASATLRLFVTIKGRPEPEVKWEKA-EGIL 25148

Query: 630   TE-------YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             T+        +FT L    + +  +   +    +          + +      P  +  R
Sbjct: 25149 TDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR 25208

Query: 683   PKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPG 736
                K+ V L W+ P  + G +++ Y VE  E      + Y      CT     + NL  G
Sbjct: 25209 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRE---TTRKAYATITNNCTKTTFRIENLQEG 25265

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS-SGA 795
               Y FRV A N+ G G  ++ +E    + PP       +         + WE P+S  G+
Sbjct: 25266 CSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGS 25325

Query: 796   DISEYRLEW-GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVL- 853
              I+ Y +E   +  E              I  L    +Y  R+ A N+ G     +L + 
Sbjct: 25326 KITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVP 25385

Query: 854   -----CQTPASAPDPVSTLCVLEEEPLD---AYPDSPSACLVLNWEEPCNNGSEILAYTI 905
                   +   S   P  T  V   E L     +   P A   +NW +      E     +
Sbjct: 25386 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQA--TVNWRKDGQTLKETTRVNV 25443

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                 T       T   +K+   E      +   N  G+      I    RP PP P R++
Sbjct: 25444 SSSKT------VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRID 25497

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFT 1024
               +    S+ + W                 + E  +  +  + +  + T  K+ RLT  +
Sbjct: 25498 EVSC--DSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGS 25555

Query: 1025  CYSFRIQAASEAGEGPFSET------YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
              Y FR+ A +  G+  +SE+      Y FS     P     P+V     ++  + W+   
Sbjct: 25556 EYQFRVCAENRYGKSSYSESSAVVAEYPFSP----PGPPGTPKVVHATKSTMLVTWQV-- 25609

Query: 1079  SMKGDPVNYILQVLVGRESEYKQ----------VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  PVN     ++G   EYK+               +   ++SGL     Y +RV A
Sbjct: 25610 -----PVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYA 25663



 Score =  119 bits (298), Expect = 2e-26
 Identities = 205/920 (22%), Positives = 336/920 (36%), Gaps = 106/920 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D    +   +VS++   +  +SWAPP       + G S    Y V   +  R     
Sbjct: 18694 RVLDTPGPVSDLKVSDVTKTSCHVSWAPP------ENDGGSQVTHYIVEKREADRKTWST 18747

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKL 387
             +    ++   ++ +L P  +Y+ RV A+      V     +PV  +     P+ P   ++
Sbjct: 18748 VTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEV 18807

Query: 388   AHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPA 444
                +K+S TL W  P+ D G+KI  Y+  + E ++ +  R   +   K   L  T L   
Sbjct: 18808 TEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPAD-RWTEYSVVKDLSLVVTGLKEG 18866

Query: 445   MGYTFRLAARNDIGTSGYSQEVVCYTLGN--IPQMPSAPRLVRA-------------GIT 489
               Y FR+AARN +G S   +    Y      +P     P  +               G  
Sbjct: 18867 KKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKP 18926

Query: 490   WVTLQWSKPEGCSPEEVITYT-LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRL 548
               T +W K E    +EV+T + L + + ++ ++             +K++ R     + L
Sbjct: 18927 HPTCKWKKGE----DEVVTSSHLAVHKADSSSIL-----------IIKDVTRKDSGYYSL 18971

Query: 549   TASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYL 608
             TA N+ G       +V     D PGPP  P     + +   S+ W  P ++GGS I  Y+
Sbjct: 18972 TAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYI 19028

Query: 609   LEITDGNSEANQWEVAY-SGSATEYTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVR 665
             +E  D       W  A  S + T      L PG  Y  R    +  G S+   S  +  +
Sbjct: 19029 VEKCD--VSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQ 19086

Query: 666   TLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-----SEV 720
                  P + +  RV  +     + + WD P S+ G  +  Y +E  E   +        +
Sbjct: 19087 FPFGVPSEPKNARVT-KVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL 19145

Query: 721   YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISC 777
                 E  C    L+ G  Y FR+ ALN  G  P S  +E  TA     PPG  K   I  
Sbjct: 19146 VRSTEYPC--AGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPG--KPEVIDV 19201

Query: 778   TPDGCVLVGWESPDSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLP 829
             T     L+        G+ I  Y +E        W     +   I       +    L  
Sbjct: 19202 TKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEE 19258

Query: 830   AAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN 889
              AQY  R  A       P         P+   DPV+ L       +D      S   V  
Sbjct: 19259 KAQYQFRAIARTAVNISP---------PSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 19309

Query: 890   WEEPCNNGS------EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR--------I 935
                 C + +        +++  D G          M + ++L     + +         I
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKD-GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTI 19368

Query: 936   QAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
              A N  G+   +  +K   +P PP   ++    +    L  +    +  +     IV   
Sbjct: 19369 TAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKR 19428

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
             +    N   +S    P  +  V++L E   Y FRI A ++ G G   F+E          
Sbjct: 19429 ETSRPNWAQVSA-TVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDP 19487

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGE--EATF 1110
             P     P ++ +  +   + W+      G P+  Y+L+    +   + +V +    E T 
Sbjct: 19488 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTL 19547

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             + +GLQ  T+Y FRV A  +
Sbjct: 19548 KATGLQEGTEYEFRVTAINK 19567



 Score =  118 bits (295), Expect = 4e-26
 Identities = 187/845 (22%), Positives = 322/845 (38%), Gaps = 110/845 (13%)

Query: 351   YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKI 409
             Y ++V   +   K  C+  V  T     P  P         K+S+  +W+ P+D+G S+I
Sbjct: 14779 YMIKVENDHGIAKAPCTVSVLDT-----PGPPINFVFEDIRKTSVLCKWEPPLDDGGSEI 14833

Query: 410   TNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTSG--YSQE 465
              NY LE  +  +          + +HCK  +TKL     Y FR+ A N  G      S+ 
Sbjct: 14834 INYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP 14893

Query: 466   VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP- 524
             +V       P  P  P +       + ++W++P+  +   ++ Y LE +E  + +     
Sbjct: 14894 LVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLEKREVNSTHWSRVN 14952

Query: 525   KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVK 581
             K     L   V  L     Y FR+ A N  G    S PS+          PGPP   +  
Sbjct: 14953 KSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTD 15012

Query: 582   GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP 639
                T+    ++W+PP  NGG EI+ Y ++     +  N+W           +YT   ++ 
Sbjct: 15013 TSSTT--IELEWEPPAFNGGGEIVGYFVDKQLVGT--NEWSRCTEKMIKVRQYTVKEIRE 15068

Query: 640   GTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHL----EWDVP 695
             G  YKLR   ++  G     E+ PV   ++A  Q  P   L       + +       +P
Sbjct: 15069 GADYKLRVSAVNAAGEGPPGETQPV---TVAEPQEPPAVELDVSVKGGIQIMAGKTLRIP 15125

Query: 696   ASESGCEV-----SEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
             A  +G  V     ++   E+ +   V   V  G + E  + + L     R+ + A N  G
Sbjct: 15126 AVVTGRPVPTKVWTKEEGELDKDRVVIDNV--GTKSELIIKDALRKDHGRYVITATNSCG 15183

Query: 751   YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE------ 803
                 +   E+    GP    K P +  T     L+ W  P D  G++I+ + +E      
Sbjct: 15184 SKFAAARVEVFDVPGPVLDLK-PVV--TNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 15240

Query: 804   --WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPAS 859
               W +  E+         ++ +I  LL   +Y  R+ A N+ G GP  E+  +L   P  
Sbjct: 15241 HTWRQPIETER-------SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 15293

Query: 860   APDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTI--------DLGDT 910
              P     L          Y +   + + L+W+EP  N GS I  Y I        D    
Sbjct: 15294 PPTSPERL---------TYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERV 15344

Query: 911   SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA--KTRPLPPL-------- 960
             +  +  TT  ++++L     Y  R++A+NEIG    S  +    +   +PP         
Sbjct: 15345 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVR 15404

Query: 961   ----------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
                       P  +     G    K++W  + +      D +   + E        + R 
Sbjct: 15405 GDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE--------VSRS 15456

Query: 1011  PSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
              + T   + +       ++ + A++  G   F   +     +  PP   A  VT ++  S
Sbjct: 15457 EAKTELSIPKAVREDKGTYTVTASNRLG-SVFRNVHVEVYDRPSPPRNLA--VTDIKAES 15513

Query: 1070  CEILWETVPSMKGDPVNYIL---QVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRV 1125
             C + W+      G  + + +   +    +++E+++V     E  + I  L  N  Y FRV
Sbjct: 15514 CYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRV 15573

Query: 1126  CACRR 1130
              A  +
Sbjct: 15574 RAVNK 15578



 Score =  118 bits (295), Expect = 4e-26
 Identities = 181/757 (23%), Positives = 289/757 (38%), Gaps = 115/757 (15%)

Query: 378   APECPFPP-KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             AP  P PP  ++     + +L W  P+ D GS ITNY++E  +  R          ++  
Sbjct: 18991 APGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTS 19050

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
             C++ KL P   Y FR+ A N  G S    S ++V      +P  P   R+ +     + +
Sbjct: 19051 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFV 19110

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTA 550
              W +P+      +I Y +E    E ++L   K     +  T      L    +Y FR+ A
Sbjct: 19111 AWDRPDSDGGSPIIGYLIE--RKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYA 19168

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G S PS+     T+     PP +P V   VT    S+ W  PK +GGS+I+ Y +E
Sbjct: 19169 LNKAGSSPPSKPTEYVTARMPVDPPGKPEVI-DVTKSTVSLIWARPKHDGGSKIIGYFVE 19227

Query: 611   I--TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTL 667
                  G+         +     EYT T L+    Y+ RA   +    S  SE S PV  L
Sbjct: 19228 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 19287

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE 727
             +    +  PPR+      K       +   ++G  V   +    +P    S    G  L+
Sbjct: 19288 A----ENVPPRIDLSVAMK------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337

Query: 728   CTVG-------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA----------GPPGQC 770
                G       NL   T+  F V   + G Y   ++ S  + +A          GPP   
Sbjct: 19338 PAEGIKMAMQRNLC--TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASV 19395

Query: 771   KAPCISCTPDGCVLVGWESP-DSSGADISEY--------RLEWGEDEESLELIYHGTDTR 821
             K   I+       ++ WE P +  G++I+ Y        R  W +   ++ +      T 
Sbjct: 19396 K---INKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI------TS 19446

Query: 822   FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDS 881
               +  L+   +Y  R+ A N+ G G               DPV T   + + P     D 
Sbjct: 19447 CSVEKLIEGHEYQFRICAENKYGVG---------------DPVFTEPAIAKNPY----DP 19487

Query: 882   PSAC------------LVLNWEEPCNN-GSEILAYTIDLGDTSITVGNTTMHVMKDLLPE 928
             P  C            + ++W+ P ++ GS I  Y ++  +T     N T    K ++  
Sbjct: 19488 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV--NWTKVNRKPIIER 19545

Query: 929   ----------TTYRIRIQAINEIGAGPFSQFIK---AKTRPLPPLPPRL-ECAAAGPQSL 974
                       T Y  R+ AIN+ G G  S   K   A+    PP PP   +       S+
Sbjct: 19546 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSV 19605

Query: 975   KLKWGDS--NSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQ 1031
              L WG    +  +     +V   + +  N    ++ +    T ++V  L E T Y FR+ 
Sbjct: 19606 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 19665

Query: 1032  AASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGN 1068
             A ++ G    S+       K  P  I  P   +L+ +
Sbjct: 19666 AVNKIGYSDPSDV----PDKHYPKDILIPPEGELDAD 19698



 Score =  118 bits (295), Expect = 4e-26
 Identities = 173/749 (23%), Positives = 277/749 (36%), Gaps = 83/749 (11%)

Query: 433   QKHCKLTKLCPAMGYTFRLAARNDIG--------TSGYSQEVVCYTLGNIPQMPSAP-RL 483
             + H K+ KL      T R     D G         +G + E +   + + P  P+ P ++
Sbjct: 29788 ETHTKVAKL------TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI 29841

Query: 484   VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQ 543
                  T +T+ W  PE      +  Y +E ++           +    T     L    +
Sbjct: 29842 DEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNE 29901

Query: 544   YKFRLTASNTEG--KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y FR+ A+N  G      SEV+ C +S   PGPP   L    V+  G ++ W PP+D+GG
Sbjct: 29902 YVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPP-ETLQIFDVSRDGMTLTWYPPEDDGG 29960

Query: 602   SEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE- 660
             S++  Y++E  +  ++          + T Y  T L  G  Y+ R   I+  G  + S  
Sbjct: 29961 SQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRP 30020

Query: 661   SLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED--- 715
             S P+  +     PG+ + PRV    +   V L W VP  E G +V+ Y +EM + +    
Sbjct: 30021 SKPIVAMDPIAPPGKPQNPRVTDTTR-TSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEW 30079

Query: 716   VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCI 775
                        E T+ +L  G  YRFRV A N GG G  ++V         PG  K   +
Sbjct: 30080 TKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEV---------PGTVKVTEM 30130

Query: 776   SCTPD---------------GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDT 820
                PD               G V+            I ++  E  +  +   +    T T
Sbjct: 30131 LEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHT 30190

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGA-GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYP 879
                I++          L   N+ G    Y ++ +  +P S   P+             Y 
Sbjct: 30191 ELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLE------------YD 30238

Query: 880   DSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVGNT-------TMHVMKDLLPETTY 931
             D     + ++W  P ++G ++IL Y ++  +       T       T  V+K L     Y
Sbjct: 30239 DIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEY 30298

Query: 932   RIRIQAINEIGAGP---FSQFIKAKTRPLPPLPPRL--ECAAAGPQSLKLKWGDSNSKTH 986
               R+ A N+ G        + +  KT   PP PP    E       S+ L W        
Sbjct: 30299 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGG 30358

Query: 987   AAEDIVYTLQLEDRNKRFISIYRGPSHT--YKVQRLTEFTCYSFRIQAASEAG---EGPF 1041
             +     Y  + E    +++   +    T  Y V  L     Y FRI A ++ G     P 
Sbjct: 30359 SRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPA 30418

Query: 1042  SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYK 1100
             SE          P       +  +  +S  + WE      G  +  Y ++     +S +K
Sbjct: 30419 SEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWK 30478

Query: 1101  QVYKG--EEATFQISGLQTNTDYRFRVCA 1127
             +  K   ++  F I GL   T+Y FRV A
Sbjct: 30479 KSNKERIKDKQFTIGGLLEATEYEFRVFA 30507



 Score =  117 bits (292), Expect = 9e-26
 Identities = 190/802 (23%), Positives = 298/802 (37%), Gaps = 63/802 (7%)

Query: 368   EPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNS 423
             EP   T    A E P PP    +   +KS+++L W  P  D GSKIT Y++E  + K + 
Sbjct: 20951 EPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIE-AQRKGSD 21009

Query: 424   GFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAP 481
              +          C +  L     YTF++ A N  G S    S+ V+      +P++    
Sbjct: 21010 QWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRG 21069

Query: 482   RLVRAGITWV--TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLK 539
                +  I      ++   P    P+  +T+    Q  +     + + T       +    
Sbjct: 21070 IYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECV 21129

Query: 540   RSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDN 599
             RS    + LTA N  G+    +V+      D PGPPT P+    V+S   +  WDPP+++
Sbjct: 21130 RSDSGPYPLTARNIVGEV--GDVITIQVH-DIPGPPTGPIKFDEVSSDFVTFSWDPPEND 21186

Query: 600   GGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC-----ISTG 653
             GG  I  Y++E+    +++  W E+A +   T Y  T L  G  Y+ R        +  G
Sbjct: 21187 GGVPISNYVVEMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPG 21244

Query: 654   GHSQC-SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE 712
               S C   + P +     PG    P+V    K   + + W  P S+ G  +  Y VE  E
Sbjct: 21245 ITSACIVANYPFK----VPGPPGTPQVTAVTK-DSMTISWHEPLSDGGSPILGYHVERKE 21299

Query: 713   PEDVASEVYHGPELECTV---GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQ 769
                +  +      +   +     L  G  Y FRV A N  G    S  SE   A  P   
Sbjct: 21300 RNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDP 21359

Query: 770   CKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL---IYHGTDTRFEIR 825
                P         V + W  P+ + G  I+ Y +E  +      L     +  +  F + 
Sbjct: 21360 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 21419

Query: 826   DLLPAAQYCCRLQAFNQAGA----GPYSELVLCQTPASAPDP------VSTLCVLEEEPL 875
              L   A Y  R+ A N AGA       S+ + C+    AP          T+ +   E  
Sbjct: 21420 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAF 21479

Query: 876   DAYPD-SPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR 934
                 D S      + W +            I + D S  + N      KD     +    
Sbjct: 21480 RLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVN------KDSTRRDSGAYT 21533

Query: 935   IQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
             + A N  G       +K   RP PP  P L       +   L W        A  D    
Sbjct: 21534 LTATNPGGFAKHIFNVKVLDRPGPPEGP-LAVTEVTSEKCVLSWFPPLDDGGAKIDHYIV 21592

Query: 995   LQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
              + E     + ++      T  KV +L +   Y FR+ A ++ G G P       +    
Sbjct: 21593 QKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPY 21652

Query: 1053  VPP-TIKAPRVTQLEGNSCEILWETVPSMKG-DPVNYILQVLVGRESEYKQVYKGEEAT- 1109
              PP   K P VT +  +S  + W    S  G + +NYI++    R+   ++  K  + T 
Sbjct: 21653 GPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVE---RRDKAGQRWIKCNKKTL 21709

Query: 1110  ----FQISGLQTNTDYRFRVCA 1127
                 +++SGL    +Y FR+ A
Sbjct: 21710 TDLRYKVSGLTEGHEYEFRIMA 21731



 Score =  117 bits (292), Expect = 9e-26
 Identities = 209/903 (23%), Positives = 342/903 (37%), Gaps = 101/903 (11%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             PQV+ +   ++ +SW  P+     P  G      Y V    K R+G      S   +  N
Sbjct: 21265 PQVTAVTKDSMTISWHEPLSDGGSPILG------YHV--ERKERNGILWQTVSKALVPGN 21316

Query: 342   LKDLRPATD---YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +      TD   Y  RV A   + K   S+P          + P  P   + ++ ++TL+
Sbjct: 21317 IFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLK 21376

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRLAARND 456
             W  P    G KIT+Y++E  +       +  F    +    ++ L     Y FR+ A+N 
Sbjct: 21377 WAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNA 21436

Query: 457   IGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITW-----------VTLQWS 496
              G     S  S  + C      P++    +     +++AG  +            T++WS
Sbjct: 21437 AGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS 21496

Query: 497   KPEGCSPEEVITYTLEIQ-EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
             K      E   T  LEI+  D + NL +            K+  R     + LTA+N  G
Sbjct: 21497 KD---GKELEGTAKLEIKIADFSTNLVN------------KDSTRRDSGAYTLTATNPGG 21541

Query: 556   KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
              +   + +      DRPGPP  PL    VTS    + W PP D+GG++I  Y+++  +  
Sbjct: 21542 FA---KHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRE-T 21597

Query: 616   SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQ 673
             S      VA     T+   T L  G  Y  R   ++  G  +  ES PV  ++    P  
Sbjct: 21598 SRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDP 21657

Query: 674   CRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTV 730
              + P V    K   V + W  P S+ G E+  Y VE  +      +        +L   V
Sbjct: 21658 PKNPEVTTITKDSMV-VCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKV 21716

Query: 731   GNLLPGTVYRFRVRALNDGGY------GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVL 784
               L  G  Y FR+ A N  G        P+    +     GPPG    P +  T    + 
Sbjct: 21717 SGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSIS 21773

Query: 785   VGWESP-DSSGADISEYRLEWG---EDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQA 839
             + W  P    G++I+ Y +E     EDE  +     G   T + I  L    +Y  R+ A
Sbjct: 21774 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 21833

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSE 899
              N  G G   E  L      A D +    +  +  L       + C +  +       + 
Sbjct: 21834 MNSEGLG---EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAP 21890

Query: 900   ILAYTIDLGDT--SITVGNTTMHVMKDLLPETTYRI---RIQAINEIGAGPFSQFIKAKT 954
              + +  D G++    ++ +T+ + +  L+     R    +     E  +G  S F+  + 
Sbjct: 21891 EVKWARDHGESLDKASIESTSSYTL--LIVGNVNRFDSGKYILTVENSSGSKSAFVNVRV 21948

Query: 955   RPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
                P  P  L+       S+ L W      G S  K +  E      + E   K + ++ 
Sbjct: 21949 LDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE------KRESTRKAYSTVA 22002

Query: 1009  RGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE- 1066
                  T +KV +L E   Y FR+ A +E G G  +E  T  + K+    +   ++T ++ 
Sbjct: 22003 TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE--TAESVKASERPLPPGKITLMDV 22060

Query: 1067  -GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFR 1124
               NS  + WE      G  +  YI+++      ++      +     I+GL    +Y FR
Sbjct: 22061 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFR 22120

Query: 1125  VCA 1127
             V A
Sbjct: 22121 VSA 22123



 Score =  115 bits (288), Expect = 3e-25
 Identities = 177/727 (24%), Positives = 291/727 (40%), Gaps = 108/727 (14%)

Query: 384   PPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFR--QCFFGSQKHC--KL 438
             P +++  S  S  L W  P D G ++ITNY++E    KR SG    Q    S K    K+
Sbjct: 28747 PIEVSSVSAESCVLSWGEPKDGGGTEITNYIVE----KRESGTTAWQLVNSSVKRTQIKV 28802

Query: 439   TKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS 496
             T L   M Y+FR+++ N  G S    S  ++       P  P+ P +       ++++W 
Sbjct: 28803 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 28862

Query: 497   KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTE 554
             +P      ++I Y +E +++ N  L+  +     L C  K   L    +Y+FR  A N  
Sbjct: 28863 EPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAA 28921

Query: 555   GKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE---- 610
             G S  SE      + +    P RP V   VT    S+ W  P  +GGS+++ Y++E    
Sbjct: 28922 GVSKASEASRPIMAQNPVDAPGRPEVTD-VTRSTVSLIWSAPAYDGGSKVVGYIIERKPV 28980

Query: 611   --ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGH-SQCSESLPVRTL 667
               + DG      + +    S   +T T L  G  Y+ R    +  G  S+ SES      
Sbjct: 28981 SEVGDGRWLKCNYTIV---SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST----- 29032

Query: 668   SIAPGQCR----PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE--------- 714
                P  CR    PP+        +  L  D+    +G ++   +    +PE         
Sbjct: 29033 --GPVTCRDEYAPPKA-----ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGD 29085

Query: 715   ---DVASEV---YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPG 768
                D+  +V   Y G      +         ++ +   N  G    S + ++  + GP G
Sbjct: 29086 KELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCG 29145

Query: 769   QCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT--DTRFEIR 825
             +     +  T + C L  W  P +  GA+I+ Y +E  E      +I  G      + + 
Sbjct: 29146 KLTVSRV--TQEKCTLA-WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVT 29202

Query: 826   DLLPAAQYCCRLQAFNQAGAGP--YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPS 883
              L+   +Y  R++A N+ G G    SE ++ +   + P P      + EE       +  
Sbjct: 29203 RLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG----IPEEV-----GTGK 29253

Query: 884   ACLVLNWEEP-CNNGSEILAYTIDLGDTS----------ITVGNTTMHVMKDLLPETTYR 932
               +++ W +P  + G+EI  Y +D  +              V +T + V   L+    Y+
Sbjct: 29254 EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTS-LMEGCDYQ 29312

Query: 933   IRIQAINEIG---AGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              R+ A+N  G       S FI  +     P PP  PR+        S+ L W  +     
Sbjct: 29313 FRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV--VDTTKHSISLAW--TKPMYD 29368

Query: 987   AAEDIV-YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTC--------YSFRIQAASEAG 1037
                DIV Y L++++++      YR   HT    R TEFT         YSFR+ A +  G
Sbjct: 29369 GGTDIVGYVLEMQEKDTD--QWYR--VHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 29424

Query: 1038  EGPFSET 1044
                +SE+
Sbjct: 29425 MSEYSES 29431



 Score =  114 bits (284), Expect = 7e-25
 Identities = 219/964 (22%), Positives = 367/964 (38%), Gaps = 124/964 (12%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             EKP+VSN+      +SW  PV        G S    Y V   +K      + I +   +L
Sbjct: 20576 EKPEVSNVTKNTATVSWKRPVD------DGGSEITGYHVERREKKSLRWVRAIKTPVSDL 20629

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH---RSKSSL 395
              C +  L+  + Y  RV A   +  G  SE         A   P PP   H    +K S 
Sbjct: 20630 RCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSA 20689

Query: 396   TLQWKAP-IDNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
             +L W  P  D G +IT Y++E        W +    +  R   F       +  L     
Sbjct: 20690 SLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQF------VVPDLQTKEK 20743

Query: 447   YTFRLAARNDIGTSGYSQ----EVVCYTLGNIPQMPSAPR---LVRAGITWVTLQWSKPE 499
             Y FR++A ND G    +     E+V   +    ++ +  R   +VRAG++   ++   P 
Sbjct: 20744 YNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLS---IRIFVPI 20800

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQY---KFRLTASNTEGK 556
                P   +T+T      +N NL +        + T+  +    +Y   KF +T  N  GK
Sbjct: 20801 KGRPAPEVTWT-----KDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK 20855

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
                    V     D PGP    L    +T    ++ WD P  +GGS I  Y++E  +   
Sbjct: 20856 KSG---FVNVRVLDTPGPVLN-LRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATR 20911

Query: 617   EANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
             ++           T Y  T L  G  Y  R    +  G  + +E+      S AP     
Sbjct: 20912 KSYSTATTKCHKCT-YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS 20970

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLP 735
               ++   K   V L W  P  + G +++ Y +E   +  D  + +     LEC V NL  
Sbjct: 20971 LNIMDITK-STVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 21029

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             G  Y F+V A+N  G     +   +        Q   P +        LV  ++ D+   
Sbjct: 21030 GEEYTFQVMAVNSAGRSAPRESRPVIVKE----QTMLPELDLRGIYQKLVIAKAGDNIKV 21085

Query: 796   DI-----SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
             +I      +  + W + ++ L+         FE      A      +    ++ +GPY  
Sbjct: 21086 EIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVRSDSGPYP- 21137

Query: 851   LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP-------SACLVLNWEEPCNNGS-EILA 902
                  T  +    V  +  ++   +   P  P       S  +  +W+ P N+G   I  
Sbjct: 21138 ----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISN 21193

Query: 903   YTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKA 952
             Y +++  T        + TV  TT    + L     Y+ R++A N  G GP   S  I A
Sbjct: 21194 YVVEMRQTDSTTWVELATTVIRTTYKATR-LTTGLEYQFRVKAQNRYGVGPGITSACIVA 21252

Query: 953   KTRPLPPLPPRL-ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIY 1008
                   P PP   +  A    S+ + W +  S    +  + Y ++ ++RN    + +S  
Sbjct: 21253 NYPFKVPGPPGTPQVTAVTKDSMTISWHEPLS-DGGSPILGYHVERKERNGILWQTVSKA 21311

Query: 1009  RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEG 1067
               P + +K   LT+   Y FR+ A + AG+  P   +        + P  K P    +  
Sbjct: 21312 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK-PVPLNITR 21370

Query: 1068  NSCEILWETVPSMKGDPV-NYILQ---VLVGR--ESEYKQVYKGEEATFQISGLQTNTDY 1121
             ++  + W       G  + +YI++   +  GR  ++ +  + + E   F +SGL  +  Y
Sbjct: 21371 HTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE---FTVSGLTEDAAY 21427

Query: 1122  RFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAA 1181
              FRV A        +  +GA SP +    + S+ +   D   ++ PK+K     D +F  
Sbjct: 21428 EFRVIA--------KNAAGAISPPS----EPSDAITCRD--DVEAPKIK----VDVKFKD 21469

Query: 1182  IIVL 1185
              ++L
Sbjct: 21470 TVIL 21473



 Score =  113 bits (283), Expect = 1e-24
 Identities = 196/861 (22%), Positives = 330/861 (38%), Gaps = 95/861 (11%)

Query: 325   RDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMY---NSVKGSCSEPVSFTTHSCAPEC 381
             R  K  ++Y   +    +  L    DY  RV A+    NS     S  +S    S  P  
Sbjct: 29288 RVNKDYVVY---DTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGP 29344

Query: 382   PFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK 440
             P  P++   +K S++L W  P+ D G+ I  Y+LE  E   +  +R     + ++ + T 
Sbjct: 29345 PSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 29404

Query: 441   LCPAMG--YTFRLAARNDIGTSGYSQ---EVVCYTLGNIPQMPSAPRL-----VRAGITW 490
                 MG  Y+FR+AA N  G S YS+   E+       IP +  A  L     +RAG   
Sbjct: 29405 PDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG--- 29461

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              +L+        P  VIT++ +  +  +  +     T       V  + R    K+ + A
Sbjct: 29462 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT--TESYSLLIVDKVNRYDAGKYTIEA 29519

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  GK   +   V     D PGP     VK  V+    ++ W+ P  +GG+ +  Y++E
Sbjct: 29520 ENQSGKKSAT---VLVKVYDTPGPCPSVKVK-EVSRDSVTITWEIPTIDGGAPVNNYIVE 29575

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC---CISTGGHSQCSESLPVRTL 667
               +    A +  V    S T Y  + L  GT+Y  R         G   + S+++ V  +
Sbjct: 29576 KREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV 29634

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP--EDVASEVYHGPE 725
              + P +     V        V L W+ P  + G  ++ Y +E  +   E     V   P 
Sbjct: 29635 PLVPAKLEVVDVT----KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPT 29690

Query: 726   -LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT------ 778
              LE TV +L  G  Y FR+RA N+ G    S+  E  TA         P I  +      
Sbjct: 29691 VLEHTVTSLNEGEQYLFRIRAQNEKGV---SEPRETVTAVTVQDLRVLPTIDLSTMPQKT 29747

Query: 779   ---PDG-----CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD--LL 828
                P G      + +    P ++    +  +L    + E + +  H    +  IR+  + 
Sbjct: 29748 IHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR---ESERVTVETHTKVAKLTIRETTIR 29804

Query: 829   PAAQYCCRLQAFNQAGAGPYS-ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV 887
                +Y   L+  N  G    + ++++   P     P+        + +DA        + 
Sbjct: 29805 DTGEYTLELK--NVTGTTSETIKVIILDKPGPPTGPIKI------DEIDA------TSIT 29850

Query: 888   LNWEEP-CNNGSEILAYTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAI 938
             ++WE P  + G+ +  Y ++  D         S +V  +T    + L     Y  R+ A 
Sbjct: 29851 ISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTR-LTEGNEYVFRVAAT 29909

Query: 939   NEIGAGPF--SQFIKAKTRPLPPLPPR-LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
             N  G G +  S+ I+ ++    P PP  L+        + L W        +        
Sbjct: 29910 NRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE 29969

Query: 996   QLEDRNKRFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
             + E R  R++ + + P     Y+   LTE   Y  R+ A +  G G P   +        
Sbjct: 29970 RKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDP 30029

Query: 1053  VPPTIKA--PRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQ--VYKGEE 1107
             + P  K   PRVT     S  + W       G  V  Y++++    + E+ +      + 
Sbjct: 30030 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKI 30089

Query: 1108  ATFQISGLQTNTDYRFRVCAC 1128
               + ++ L    +YRFRV AC
Sbjct: 30090 REYTLTHLPQGAEYRFRVLAC 30110



 Score =  112 bits (281), Expect = 2e-24
 Identities = 187/798 (23%), Positives = 293/798 (36%), Gaps = 83/798 (10%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P PP+   ++   K S  L WK P+D+G S ITNY++E  +   ++ +      S+K   
Sbjct: 17310 PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKKSH 17368

Query: 438   LTK-LCPAMGYTFRLAARNDIGTSGYSQE---VVCYTLGNIPQMPSAPRLVRAGITWVTL 493
               K L     Y FR+AA N  G   + +    +      + P  P     V    T V+L
Sbjct: 17369 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 17428

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
              W+KP+      +  Y +E QE+   +    K T  +L C V  L++   Y+FR+ A N 
Sbjct: 17429 VWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAENI 17487

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTR---PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              G   P   +          P       L++G V   G +V++            K+   
Sbjct: 17488 VGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-- 17545

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              TDG SE    E         YT       ++  ++ C     G  Q + S    + ++A
Sbjct: 17546 -TDG-SEIKTDE--------HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVA 17595

Query: 671   --------PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVY 721
                     PG    P  +     + + + W  P  + G  V  Y VE  +  +D    V 
Sbjct: 17596 VHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVS 17655

Query: 722   HGP-ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISC 777
              G  + +  + +L  G  Y FRVRA N  G GP  D S  T A     PP     P ++ 
Sbjct: 17656 SGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLD-STPTVAKHKFSPPSPPGKPVVTD 17714

Query: 778   TPDGCVLVGWESPDSSGAD-ISEYRLEWGEDEESLELIYHG--TDTRFEIRDLLPAAQYC 834
               +    V W  P S G   I+ Y +E  E       +      D +F +  L     Y 
Sbjct: 17715 ITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 17774

Query: 835   CRLQAFNQAGAG---PYSELVLCQTPASAPDPVSTLCVLEEEPLDA-YPDSPSACLVLNW 890
              R+ A N AG     P S+ +    P   P P          P++    D       L W
Sbjct: 17775 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGP----------PINPKLKDKSRETADLVW 17824

Query: 891   EEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKD------------LLPETTYRIRIQA 937
              +P ++G S IL Y ++         N    + KD            L+    YR RI+A
Sbjct: 17825 TKPLSDGGSPILGYVVECQKPGTAQWN---RINKDELIRQCAFRVPGLIEGNEYRFRIKA 17881

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGD-----SNSKTHAAEDIV 992
              N +G G   +  ++        PP +E        + ++ G      +  K     DI 
Sbjct: 17882 ANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDIT 17941

Query: 993   YTLQ--LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             +T +  +  R KR   I   P    +++         + I A + +G    S        
Sbjct: 17942 WTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGS---AIVNV 17998

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
                P   +  +VT +   +C I WE      G  + N+I++     +  +  V       
Sbjct: 17999 LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 18058

Query: 1110  FQISGLQTNTDYRFRVCA 1127
                + L  N +Y FRVCA
Sbjct: 18059 LIKANLLANNEYYFRVCA 18076



 Score =  112 bits (279), Expect = 3e-24
 Identities = 202/906 (22%), Positives = 332/906 (36%), Gaps = 95/906 (10%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             + P+V+ +    + + W PP       + G      Y +   +K       +  S   E 
Sbjct: 18400 DPPEVTKVSKEEMTVVWNPP------EYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPER 18453

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSL 395
                +++L P  +Y  RV A      G  S P          E P PP   ++   +K S+
Sbjct: 18454 RMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSI 18513

Query: 396   TLQWKAPI-DNGSKITNYLLEWD----EGKRNSGFRQCFFGSQ---KHCKLTKLCPAMGY 447
             TL W  P+ D G+ I  Y++E      +   + G+++C   +Q   K   +T L     Y
Sbjct: 18514 TLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEY 18573

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR--------LVRAG--ITWVTLQWSK 497
              FR+ A+N +G    ++         I + P            +VRAG  I    +   +
Sbjct: 18574 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 18633

Query: 498   PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS 557
             P        +     +++ + D +    +        + N  R    K+ LT  N  G+ 
Sbjct: 18634 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFL------VIPNSTRDDSGKYSLTLVNPAGEK 18687

Query: 558   CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
                 V V     D PGP +  L    VT     V W PP+++GGS++  Y++E  +  ++
Sbjct: 18688 A---VFVNVRVLDTPGPVS-DLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKRE--AD 18741

Query: 618   ANQWE-VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP-GQCR 675
                W  V      T +  T+L PG  Y  R   ++  G    ++ +P   L+  P  +  
Sbjct: 18742 RKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTD-VPKPVLASDPLSEPD 18800

Query: 676   PPRVL--GRPKHKEVHLEWDVPASESGCEVSEYSV---EMTEPEDVASEVYHGPELECTV 730
             PPR L           L W  P  + G ++  Y     E  +P D  +E     +L   V
Sbjct: 18801 PPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVV 18860

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE-- 788
               L  G  Y+FRV A N  G     +   +  A     Q   P I       +  G +  
Sbjct: 18861 TGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA---KEQLLPPKILMPEQITIKAGKKLR 18917

Query: 789   -SPDSSGADISEYRLEWGEDE--ESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQA 843
                   G      + + GEDE   S  L  H  D+     I+D+         L A N +
Sbjct: 18918 IEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 18977

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILA 902
             G       V+       P P          P D       AC  L+W  P  + GS I  
Sbjct: 18978 GTDTQKIKVVVMDAPGPPQP----------PFDISDIDADAC-SLSWHIPLEDGGSNITN 19026

Query: 903   YTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAK 953
             Y ++  D S         +V  T+  V K L+P   Y  R++A N  G + P +      
Sbjct: 19027 YIVEKCDVSRGDWVTALASVTKTSCRVGK-LIPGQEYIFRVRAENRFGISEPLTSPKMVA 19085

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN-----KRFIS 1006
               P  +P  P            + + W D       +  I Y ++ ++RN     K   +
Sbjct: 19086 QFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLIERKERNSLLWVKANDT 19144

Query: 1007  IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
             + R  S  Y    L E   YSFRI A ++AG  P S+   + T +        P V  + 
Sbjct: 19145 LVR--STEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVT 19202

Query: 1067  GNSCEILWETVPSMKGDP-VNYILQVLVGRESEYKQV----YKGEEATFQISGLQTNTDY 1121
              ++  ++W       G   + Y ++       ++ +     ++  +  +  +GL+    Y
Sbjct: 19203 KSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQY 19262

Query: 1122  RFRVCA 1127
             +FR  A
Sbjct: 19263 QFRAIA 19268



 Score =  109 bits (273), Expect = 1e-23
 Identities = 207/916 (22%), Positives = 353/916 (38%), Gaps = 89/916 (9%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             V  ++  +  L W PP+        G +   +Y +   +  R     +     +    ++
Sbjct: 24124 VKEVRKDSAFLVWEPPI------IDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVE 24177

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
             +L     Y+ RV A      G   E V     +  P  P    L   S++S +L W+ P 
Sbjct: 24178 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 24237

Query: 404   -DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTS 460
              D GS++  Y++E          +       K C   +T L     Y FR+ A N+ G S
Sbjct: 24238 HDGGSRVLGYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS 24294

Query: 461   G---YSQEVVCYTLGNIP--QMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                     V+   L   P  ++P     ++AG     L+   P    P   I++  + + 
Sbjct: 24295 DPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAG---EDLKIEIPVIGRPRPNISWVKDGEP 24351

Query: 516   DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              +     + + T       +K   +    K+ +TA+N+ G +  +  ++     ++PGPP
Sbjct: 24352 LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL---EKPGPP 24408

Query: 576   TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VAYSGSATEYTF 634
               P+    V++    + W+PP   GG +I  Y++E  D  +    W  V+ + + T    
Sbjct: 24409 VGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRD--TTTTTWHMVSATVARTTIKI 24466

Query: 635   THLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEW 692
             T LK GT Y+ R    +  G S    S+++ V+     PG    P V    K  ++ ++W
Sbjct: 24467 TKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISK-DQMLVQW 24525

Query: 693   DVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDG 749
               P ++ G ++  Y +E  E   +     +   ++ T      L  G  Y F+V A N  
Sbjct: 24526 HEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIV 24585

Query: 750   GYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWG 805
             G G  S VSE   A     PPG+ +A  I+      V + W+ P    G+ I+ Y +E  
Sbjct: 24586 GIGKPSKVSECFVARDPCDPPGRPEAIVIT---RNNVTLKWKKPAYDGGSKITGYIVEKK 24642

Query: 806   E--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAG--------AGPYSELVLC 854
             +  D   ++  +    +T F +  L+   +Y  R+ A N AG        +G  +     
Sbjct: 24643 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEI 24702

Query: 855   QTPASAPDP----VSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
               P ++ DP    V  +   E   L+A     P   +V  W +   +G E L  T    +
Sbjct: 24703 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVV--WSK---DGKE-LEETAARME 24756

Query: 910   TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAA 969
                T+  TT+ V+KD +     +  ++  N  G       +K   RP PP  P L+    
Sbjct: 24757 IKSTIQKTTL-VVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP-LKVTGV 24814

Query: 970   GPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH----TYKVQRLTEFTC 1025
               +   L W   N         +    +E R    +S  +  +      YKV +L     
Sbjct: 24815 TAEKCYLAW---NPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNE 24871

Query: 1026  YSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             Y FR+ A ++ G G   E+   T       P     P V+ +  +S  + W       G 
Sbjct: 24872 YIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGT 24931

Query: 1084  PV-NYILQVLVGRESEYKQVYKGEEAT-----FQISGLQTNTDYRFRVCACRRCLDTSQE 1137
              +  YIL+    R+ E  +  K  + T      +++GL     Y FRV A        + 
Sbjct: 24932 EIEGYILE---KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAA--------EN 24980

Query: 1138  LSGAFSPSAAFVLQRS 1153
              +G   PS   V  R+
Sbjct: 24981 AAGVGEPSEPSVFYRA 24996



 Score =  109 bits (272), Expect = 2e-23
 Identities = 217/913 (23%), Positives = 347/913 (38%), Gaps = 114/913 (12%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+N+      +SW  P  L  G     +F   Y      K     + I+ S        
Sbjct: 18009 KVTNVTKENCTISWENP--LDNGGSEITNFIVEYR-----KPNQKGWSIVASDVTKRLIK 18061

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
              +L    +Y+ RV A      G   E   P+        P  P    +A + K+ + L+W
Sbjct: 18062 ANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKW 18121

Query: 400   KAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK--HCKLTKLCPAMGYTFRLAARND 456
             + P  D GS   +Y +E    K +  + +   GS K  H  + +      Y FR+  +N+
Sbjct: 18122 RRPDYDGGSPNLSYHVE-RRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 18180

Query: 457   IGTSGY--SQEVVCYTLGNIPQMP---SAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
              G S +  ++EVV       P +    S    V+AG T + L+        PE  + +T 
Sbjct: 18181 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDT-IRLEAGVRGKPFPE--VAWTK 18237

Query: 512   EIQEDENDNLFHPKYT----GEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +  +D  D    P+       +    ++   KRS   K+ +TA+NT G    S V   T 
Sbjct: 18238 D--KDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG----SFVAYATV 18291

Query: 568   SP-DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
             +  D+PGP  R L    V+S   +V WDPP+D+GG EI  Y+LE  +  ++   W   YS
Sbjct: 18292 NVLDKPGP-VRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCE--TKRMVWS-TYS 18347

Query: 627   GSATE--YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPRVLGR 682
              +      T T L  G  Y  R    +  G    +ES PV  +T    PG+  PP V  +
Sbjct: 18348 ATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-K 18406

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVY 739
                +E+ + W+ P  + G  ++ Y +E  E      V       PE    V NLLP   Y
Sbjct: 18407 VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEY 18466

Query: 740   RFRVRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
             +FRV+A N+ G G  S  S    A     PPG      +  T    + +GW  P    GA
Sbjct: 18467 QFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGA 18526

Query: 796   DISEYRLE-------------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQ 842
              I  Y +E             W     + +L+       F +  L    +Y  R+ A NQ
Sbjct: 18527 PIIGYVVEMRPKIADASPDEGWKRCNAAAQLV----RKEFTVTSLDENQEYEFRVCAQNQ 18582

Query: 843   AGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
              G G          PA   + +    +LE   +D   D+    LV+        G  I  
Sbjct: 18583 VGIG---------RPAELKEAIKPKEILEPPEIDL--DASMRKLVI-----VRAGCPIRL 18626

Query: 903   YTIDLGDTS-------ITVGNTTMHVMKDL--------LPETTY----RIRIQAINEIGA 943
             + I  G  +       + + N       DL        +P +T     +  +  +N   A
Sbjct: 18627 FAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP--A 18684

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
             G  + F+  +    P     L+ +     S  + W    +   +        + E   K 
Sbjct: 18685 GEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT 18744

Query: 1004  FISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG---PFSETYTFSTTKSVPPTIKA 1059
             + ++      T + V  L     Y FR+ A +E G G      +    S   S P   + 
Sbjct: 18745 WSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRK 18804

Query: 1060  PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE-----YKQVYKGEEATFQISG 1114
               VT++  NS  + W  +P ++         +   RE E     + +    ++ +  ++G
Sbjct: 18805 LEVTEMTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG 18862

Query: 1115  LQTNTDYRFRVCA 1127
             L+    Y+FRV A
Sbjct: 18863 LKEGKKYKFRVAA 18875



 Score =  108 bits (271), Expect = 2e-23
 Identities = 153/654 (23%), Positives = 249/654 (38%), Gaps = 100/654 (15%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGS--QKH 435
             P PP+   +      S  L W AP+DNG S+IT+Y+++  +  R     +    +  +K 
Sbjct: 15498 PSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKR 15557

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSGY--SQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
               + KL P   Y FR+ A N  G S    S +VV      +P  P  P+++      + +
Sbjct: 15558 YGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLV 15617

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFH------PKYTGEDLTCTVKNLKRSTQYKFR 547
              W+ P       +  Y LE +E+ +            K   + +   V  L    +Y+FR
Sbjct: 15618 SWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFR 15677

Query: 548   LTASNTEGKSCPSEVLVCTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEI 604
               A N  G   PSE      + D    PGPP+ P VK   T    S+ W PP  +GGS I
Sbjct: 15678 AMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDK-TKSSISLGWKPPAKDGGSPI 15736

Query: 605   LKYLLEITDGNSEANQWEVAYSG----SATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
               Y++E+ +  +    W+         +  E    +LK    Y+ R   ++  G S+ S+
Sbjct: 15737 KGYIVEMQEEGT--TDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSD 15794

Query: 661   S---LPVRTLSIAP-----------------GQCRPPRVL-GRPKHKEVHLEWDVPA-SE 698
             +   +P   +   P                  Q R P V+ GRP  K     W+    ++
Sbjct: 15795 TTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKS---SWEFDGKAK 15851

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVS 758
                +   + +    PED   E      +   +         ++ + A N  G    +   
Sbjct: 15852 KAMKDGVHDI----PEDAQLETAENSSV-IIIPECKRSHTGKYSITAKNKAGQKTANCRV 15906

Query: 759   EITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGAD-ISEYRLEWG--EDEESLELIY 815
             ++    GPP   K   +S    G   + W+ PD  G D I  Y +E    + +   ++  
Sbjct: 15907 KVMDVPGPPKDLK---VSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNP 15963

Query: 816   HGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPL 875
                 T F + DLL   QY  R++A N+ G GP  E +   T   A DP+           
Sbjct: 15964 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT---ARDPI----------- 16009

Query: 876   DAYPDSPSACLV----------LNWEEPCNNG-SEILAYTIDL--GDTSITVGNT----- 917
               YP  P   L           L+W+ P N+G S +  Y ++    D + T         
Sbjct: 16010 --YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCN 16067

Query: 918   ------TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                       ++DL+    Y  R++A+N  G    S  +       P +PP ++
Sbjct: 16068 KRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 16121



 Score =  103 bits (256), Expect = 1e-21
 Identities = 216/952 (22%), Positives = 362/952 (38%), Gaps = 106/952 (11%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             +KP V ++ + ++++ W  P   +  P  G       EV  +   R  K  +      L+
Sbjct: 14907 DKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLE-KREVNSTHWSRVNKSLL----NALK 14960

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVS-FTTHS-CAPECPFPPKLAHRSKSSLTL 397
              N+  L     Y  RV A   +  G  S P    T H   +P  P  P++   S +++ L
Sbjct: 14961 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIEL 15020

Query: 398   QWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPAMGYTFRL 451
             +W+ P  NG  +I  Y ++    K+  G  +    ++K  K+ +     +     Y  R+
Sbjct: 15021 EWEPPAFNGGGEIVGYFVD----KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 15076

Query: 452   AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---VRAGITWV---TLQWSKPEGCSPEE 505
             +A N  G  G   E    T+   PQ P A  L   V+ GI  +   TL+        P  
Sbjct: 15077 SAVNAAG-EGPPGETQPVTVAE-PQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVP 15134

Query: 506   VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
                +T E  E + D +      G      +K+  R    ++ +TA+N    SC S+    
Sbjct: 15135 TKVWTKEEGELDKDRVVIDN-VGTKSELIIKDALRKDHGRYVITATN----SCGSKFAAA 15189

Query: 566   TTSP-DRPGPPTRPLVKGPVTSHGFSV-KWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
                  D PGP     +K  VT+    +  W  P+D+GGSEI  +++E  D  ++ + W  
Sbjct: 15190 RVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKD--AKMHTWRQ 15245

Query: 624   AYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP 683
                   ++   T L  G  YK R    +  G     E  P+  +        P R+    
Sbjct: 15246 PIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTE 15305

Query: 684   KHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGTVY 739
             + K  + L+W  P S  G  +  Y +E    +    E  +    P     V NL    +Y
Sbjct: 15306 RTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMY 15365

Query: 740   RFRVRALND-GGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS 798
              FRV+A+N+ G   P   ++ +      P   K   +S   D  + V    P    AD++
Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLR-LSVRGD-TIKVKAGEPVHIPADVT 15423

Query: 799   EY---RLEWGEDEESL------------ELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                  ++EW ++E  +            E+      T   I   +   +    + A N+ 
Sbjct: 15424 GLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRL 15483

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILA 902
             G+   +  V        P P   L V + +    Y         L W+ P +N GSEI  
Sbjct: 15484 GSVFRNVHV---EVYDRPSPPRNLAVTDIKAESCY---------LTWDAPLDNGGSEITH 15531

Query: 903   YTIDLGDTS------ITVGNTTM---HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
             Y ID  D S        V NT +   + +  L+P   Y  R++A+N+ G     +  K  
Sbjct: 15532 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVV 15591

Query: 954   TR-----PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
              +     P PP  P++     G  S+ + W        +     +  + E+ +  +  + 
Sbjct: 15592 IQDPYRLPGPPGKPKVLARTKG--SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVS 15649

Query: 1009  RGP-------SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS---VPPTIK 1058
             R P          + V RL E   Y FR  A + AG GP SE             P    
Sbjct: 15650 RAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPS 15709

Query: 1059  APRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEE----ATFQIS 1113
              P V     +S  + W+      G P+  YI+++     +++K+V + ++        + 
Sbjct: 15710 CPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVP 15769

Query: 1114  GLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLD 1165
              L+    YRFRV A     ++    +    P A  + +  EV +  D+G+ D
Sbjct: 15770 NLKELRKYRFRVKAVNEAGESEPSDTTGEIP-ATDIQEEPEVFI--DIGAQD 15818



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 204/939 (21%), Positives = 334/939 (35%), Gaps = 131/939 (13%)

Query: 286   NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEEL------- 338
             ++ A+    +  PP  L+    +       +E   +D GR  +  +I   E L       
Sbjct: 14174 SVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKA 14233

Query: 339   ------ECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH- 389
                   +CN +  D+   T+   +V A   +  G  SEP    +       P PP   H 
Sbjct: 14234 GKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV 14293

Query: 390   --RSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK------ 440
                 +  + + WK P  NG S I  Y +E            C  G++K  ++        
Sbjct: 14294 TDAGRKHIAIAWKPPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNSRPIKDL 14342

Query: 441   -------LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT- 492
                    + P   Y  R+ A N IG S  S E+    +   P       L    I  +  
Sbjct: 14343 KFKVEEGVVPDKEYVLRVRAVNAIGVSEPS-EISENVVAKDPDCKPTIDLETHDIIVIEG 14401

Query: 493   --LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
               L    P    P   +++  + +E +  +    K         V    R+    + +T 
Sbjct: 14402 EKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITL 14461

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G +  S  +     P     P + +    +T     + W+PP+ +GG+ IL Y+LE
Sbjct: 14462 ENKLGSATASINVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
               +         V    +   +T   L P   Y  R   ++  G  +  E L    ++  
Sbjct: 14518 RREA-GRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE-LKNPVIAQD 14575

Query: 671   PGQCRPPRV---LGRPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGP 724
             P Q   P V   +  P  + + + W  P  + G ++  Y +E     E        +  P
Sbjct: 14576 PKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 14635

Query: 725   ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKA------------ 772
              L  T   L  G  Y+FRVRA N  G    S  +  T A  P    K             
Sbjct: 14636 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGD 14695

Query: 773   -------------PCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEE---------S 810
                          P I+   D  V+V  E    +   +   + E  E+E          S
Sbjct: 14696 EIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLS 14755

Query: 811   LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
             ++    G +++  +RD L        ++  N  G             A AP  VS L   
Sbjct: 14756 IDNSKKG-ESQLRVRDSLRPDHGLYMIKVENDHGI------------AKAPCTVSVLDTP 14802

Query: 871   EEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTS------ITVGNTTMHV-- 921
                    + D     ++  WE P ++ GSEI+ YT++  D +      I V +T  H   
Sbjct: 14803 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY 14862

Query: 922   -MKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPP-LPPRLECAAAGPQSLKLK 977
              +  L+    Y  R++A N  G GP   S+ + AK    PP  P +         S+ +K
Sbjct: 14863 SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVK 14922

Query: 978   WGDSNSKTHAAEDIVYTLQLEDRNKRFIS-IYRGPSHTYK--VQRLTEFTCYSFRIQAAS 1034
             W +   K + +  + Y L+  + N    S + +   +  K  V  L E   Y FR+ A +
Sbjct: 14923 WNE--PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAEN 14980

Query: 1035  EAGEGPFSETYTFSTTKS--VPPTIKAPRVTQLEGNSCEILWETVPSMK--GDPVNYILQ 1090
              AG G FS      T      PP    PRVT     + E+ WE  P+    G+ V Y + 
Sbjct: 14981 AAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEP-PAFNGGGEIVGYFVD 15039

Query: 1091  VLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
               +   +E+ +  +   +   + +  ++   DY+ RV A
Sbjct: 15040 KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA 15078



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 90/306 (29%), Positives = 137/306 (44%), Gaps = 22/306 (7%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +  +IQ R+V +SW PP         G +    Y +   +  +   Y I          +
Sbjct: 30236 EYDDIQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLVV 30289

Query: 343   KDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPF-PPKLAHRSKSSLTLQ 398
             K L+   +YH RV A      S      EPV+  T    PE P  PP++   +KSS++L 
Sbjct: 30290 KGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLS 30349

Query: 399   WKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W  P D+G S++T Y +E  E   +   R      +     +T L P   Y FR+ A+ND
Sbjct: 30350 WSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQND 30409

Query: 457   IG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             +G   TS  S+ VVC    + P  P    ++      VTLQW KPE    +E++ Y +E 
Sbjct: 30410 VGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEY 30469

Query: 514   QEDENDNLFHP--KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC----TT 567
             ++   D+ +    K   +D   T+  L  +T+Y+FR+ A N  G S P    +      T
Sbjct: 30470 RQS-GDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLT 30528

Query: 568   SPDRPG 573
             S + PG
Sbjct: 30529 SGEAPG 30534



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 188/836 (22%), Positives = 298/836 (35%), Gaps = 141/836 (16%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPIDN-GSKITNYLLE--------WDEGKRNSGFRQ 427
             + P PPK   ++  ++ S  L WK P D+ G +I  Y++E        W +   + G   
Sbjct: 15910 DVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG--- 15966

Query: 428   CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-VRA 486
                       +  L     Y FR+ A N  G  G   E +  T    P  P  P + ++ 
Sbjct: 15967 -----STTFVVPDLLSEQQYFFRVRAENRFGI-GPPVETIQRTTARDPIYPPDPPIKLKI 16020

Query: 487   GI---TWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP------KYTGEDLTCTVKN 537
             G+     V L W  P+      V  Y +E    +             K   E+L  TV++
Sbjct: 16021 GLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 16080

Query: 538   LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVK----- 592
             L    +Y+FR+ A N  G S PS  +          PP+  L +      G +V      
Sbjct: 16081 LVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKI 16140

Query: 593   ---------W--DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGT 641
                      W   PPK     E + Y       ++  N+  V  + +           G 
Sbjct: 16141 KGVPFPTLTWFKAPPKKPDNKEPVLY-------DTHVNKLVVDDTCTLVIPQSRRSDTG- 16192

Query: 642   LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
             LY + A           S+ + +  L   PG    P         ++ L W  P  + G 
Sbjct: 16193 LYTITA----VNNLGTASKEMRLNVLG-RPGPPVGPIKFESVSADQMTLSWFPPKDDGGS 16247

Query: 702   EVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             +++ Y +E  E              EC  T+  LL G  Y FR+ A N  G G   D SE
Sbjct: 16248 KITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLD-SE 16306

Query: 760   ITTAA---GPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE--------- 806
               TA      PG    P +S      + V WE P+   G+ ++ Y LE  +         
Sbjct: 16307 PETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 16366

Query: 807   DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
             + + ++ +  G    +++  L+  + Y  R+ A N AG GP S   L   PA+A DP++ 
Sbjct: 16367 NRDPIKAMTLGVS--YKVTGLIEGSDYQFRVYAINAAGVGPAS---LPSDPATARDPIAP 16421

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTIDL---GDTSITVGNT----- 917
                    P     D   +   L W  P  + GS++  Y ++    G      G       
Sbjct: 16422 ----PGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 16477

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTRPLPPLPP------------ 962
             T  V+  L     Y+ R++A+N  G    G  +  I+ K R + P               
Sbjct: 16478 TKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVH 16537

Query: 963   -----RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKV 1017
                  R+    +G     + W + N +T   E  + T  +              S   K 
Sbjct: 16538 AGGVIRIIAYVSGKPPPTVTW-NMNERTLPQEATIETTAISS------------SMVIKN 16584

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVT-QLEGNSCEILWET 1076
              + +    YS  + A +EAGE    +         VP  +  P +   L   SC++ W +
Sbjct: 16585 CQRSHQGVYS--LLAKNEAGE---RKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 16639

Query: 1077  VPSMKGDPV-NYILQVLVGRESEYKQ----VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  G P+ NY+++    RES+ +      Y        + GL     Y FR+ A
Sbjct: 16640 PEDDGGSPITNYVIE---KRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAA 16692



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 217/939 (23%), Positives = 341/939 (36%), Gaps = 118/939 (12%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             +V D+   +   +V+      V L+W  P+        G S    Y V   D  R     
Sbjct: 13085 KVIDVPGPVRNLEVTETFDGEVSLAWEEPLT------DGGSKIIGYVVERRDIKRKTWVL 13138

Query: 331   IIYSGEELECNLKDLRPA-TDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPK 386
                  E  E  +  L+    +Y  RV A      G   E   PV   +    P  P    
Sbjct: 13139 ATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVT 13198

Query: 387   LAHRSKSSLTLQWKAP-IDNGSKITNYLLEW-DEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
             +   ++  ++L W+ P  D G++ITNY++E  D+                   +T +   
Sbjct: 13199 ITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEG 13258

Query: 445   MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQWSKP--E 499
               Y+FR+ A+N IG    S       + +  + PS P  L  +  T   V L+W  P  +
Sbjct: 13259 QEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKD 13318

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
             G SP  ++ Y +E  E+  DN          +LT  V  L++  +Y +R++A N  G S 
Sbjct: 13319 GGSP--ILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSD 13376

Query: 559   PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
             PSE+L   T+ D    PT  L        G  V    P        +  L+  T      
Sbjct: 13377 PSEILGPLTADDAFVEPTMDL---SAFKDGLEVIVPNP--------ITILVPSTGYPRPT 13425

Query: 619   NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQ-----CSESLPVRTLS----- 668
               W     G     T   +K  TL       IS    S            V+T+S     
Sbjct: 13426 ATW---CFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDV 13482

Query: 669   --IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE--PEDVASEVYHGP 724
               IA          G      VHL W+ P  + G  ++ Y VE  E   +     +    
Sbjct: 13483 NVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT 13542

Query: 725   ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---ITTAAGPPGQCKAPCISCTPDG 781
             +LE TV +L+ G  Y F+V A N  G G  + V E   ++T A  P   +          
Sbjct: 13543 DLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN 13602

Query: 782   CVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLPAAQ 832
              + + W+ P +  G+ I  Y +E        W    E +       +T+ E+  L     
Sbjct: 13603 SIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPV------AETKMEVTGLEEGKW 13656

Query: 833   YCCRLQAFNQAGAG----PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL 888
             Y  R++A N+ GA     P  E+    T   AP+    + +L    + A         V 
Sbjct: 13657 YAYRVKALNRQGASKPSRPTEEIQAVDT-QEAPEIFLDVKLLAGLTVKAGTKIELPATVT 13715

Query: 889   NWEEPCNNGSEILAYTIDLGDTSITVGN----TTMHVMKDLLPETTYRIRIQAINEIGAG 944
                EP    ++  A  I   D  IT+ N    +T+ ++     +T   I I+A+N  G  
Sbjct: 13716 GKPEPKITWTK--ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRA 13772

Query: 945   PFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDR 1000
                  +    +P P  P   +      +S  L W     D  SK         T  + +R
Sbjct: 13773 TAVVEVNVLDKPGP--PAAFDITDVTNESCLLTWNPPRDDGGSK--------ITNYVVER 13822

Query: 1001  NKRFISIYRGPSHT-----YKVQRLTEFTCYSFRIQAASEAGEG------PFSETYTFST 1049
                   ++   S T     +K  +L     Y FR+ A +  G G      P +  Y F  
Sbjct: 13823 RATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDP 13882

Query: 1050  TKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--GE 1106
                 PPT   P  + +  ++  + W       G P+  Y ++ L     ++ +  K   +
Sbjct: 13883 PG--PPTRLEP--SDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVK 13938

Query: 1107  EATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPS 1145
             + T+++ GL     YRFRV A        + L+G   PS
Sbjct: 13939 DTTYRVKGLTNKKKYRFRVLA--------ENLAGPGKPS 13969



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 195/897 (21%), Positives = 325/897 (36%), Gaps = 83/897 (9%)

Query: 286   NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC--NLK 343
             +I+  +V+  W PP+        G S   +Y +   DK +     I+ +     C  ++ 
Sbjct: 14812 DIRKTSVLCKWEPPLD------DGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVT 14865

Query: 344   DLRPATDYHVRVYAMYNSVKGS--CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
              L    +Y  RV A      G    S+P+        P+ P  P +   + +S+ ++W  
Sbjct: 14866 KLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNE 14925

Query: 402   PIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
             P DNGS I  Y LE  E      S   +    + K   +  L   + Y FR+ A N  G 
Sbjct: 14926 PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALK-ANVDGLLEGLTYVFRVCAENAAGP 14984

Query: 460   SGYSQEVVCYTLGN--IPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ-ED 516
               +S      T  +   P  P  PR+     T + L+W  P      E++ Y ++ Q   
Sbjct: 14985 GKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVG 15044

Query: 517   ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
              N+     +   +    TVK ++    YK R++A N  G+  P E    T +  +  PP 
Sbjct: 15045 TNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQE-PPA 15103

Query: 577   RPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
               L   VKG +          P    G     K   +  +G  + ++  +   G+ +E  
Sbjct: 15104 VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTK-EEGELDKDRVVIDNVGTKSEL- 15161

Query: 634   FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQC--RPPRVLGRPKHKEVH 689
                +    L K     + T  +S C        + +   PG      P V  R   K   
Sbjct: 15162 ---IIKDALRKDHGRYVITATNS-CGSKFAAARVEVFDVPGPVLDLKPVVTNR---KMCL 15214

Query: 690   LEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP----ELECTVGNLLPGTVYRFRVRA 745
             L W  P  + G E++ + +E    +D     +  P      +C +  LL G  Y+FRV A
Sbjct: 15215 LNWSDPEDDGGSEITGFIIER---KDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIA 15271

Query: 746   LNDGGYGPYSDVSEITTA--AGPPGQCKAPCISCTPDGCVLVGWESPDSS-GADISEYRL 802
              N  G GP  ++  I      GPP   +    +      + + W+ P S+ G+ I  Y +
Sbjct: 15272 KNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYII 15331

Query: 803   E-WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPA 858
             E    D+   E +       T F + +L     Y  R++A N+ G + P   L +     
Sbjct: 15332 EKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDD 15391

Query: 859   SAPDPV--------STLCVLEEEPLDAYPDSPSACL-VLNW---EEPCNNGSEILAYTID 906
               P  +         T+ V   EP+    D     +  + W   E      ++ L  T +
Sbjct: 15392 EVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKE 15451

Query: 907   LGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLEC 966
               + S +   T + + K  + E      + A N +G+   +  ++   RP P  P  L  
Sbjct: 15452 --EVSRSEAKTELSIPK-AVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSP--PRNLAV 15506

Query: 967   AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFIS----IYRGPSHTYKVQRLTE 1022
                  +S  L W D+      +E   Y +   D +++               Y + +L  
Sbjct: 15507 TDIKAESCYLTW-DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIP 15565

Query: 1023  FTCYSFRIQAASEAG--EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
                Y FR++A ++ G  +   S+         +P     P+V      S  + W      
Sbjct: 15566 NGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDN 15625

Query: 1081  KGDPV-NYILQ---------VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
              G P+  Y L+           V R    K   KG E  F +  L     Y+FR  A
Sbjct: 15626 GGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVE--FNVPRLLEGVKYQFRAMA 15680



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 143/644 (22%), Positives = 251/644 (38%), Gaps = 65/644 (10%)

Query: 527   TGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
             T E  +  +   K+  + ++++   N  GK+   E  +     D PGP  R L       
Sbjct: 13048 TAEQTSFRILEAKKGDKGRYKIVLQNKHGKA---EGFINLKVIDVPGP-VRNLEVTETFD 13103

Query: 587   HGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHL-KPGTLYK 644
                S+ W+ P  +GGS+I+ Y++E  D   +   W +A     + E+T T L K G  Y 
Sbjct: 13104 GEVSLAWEEPLTDGGSKIIGYVVERRD--IKRKTWVLATDRAESCEFTVTGLQKGGVEYL 13161

Query: 645   LRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPR--VLGRPKHKEVHLEWDVPASES 699
              R      + TG   +    +  R+    PG   PP    +       V L W+ P  + 
Sbjct: 13162 FRVSARNRVGTGEPVETDNPVEARSKYDVPG---PPLNVTITDVNRFGVSLTWEPPEYDG 13218

Query: 700   GCEVSEYSVEMTEPEDV---ASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSD 756
             G E++ Y +E+ +   +    +      +L  TV +++ G  Y FRVRA N  G G  S 
Sbjct: 13219 GAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSA 13278

Query: 757   VSEITTAAGPPGQCKAPCISCTPD---GCVLVGWESP-DSSGADISEY---RLEWGEDEE 809
              +     A P  +   P    + D     V + WE P    G+ I  Y   R E G+D  
Sbjct: 13279 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 13338

Query: 810   ---SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASA-PDPVS 865
                +++L+    +  +++  L    +Y  R+ A N+AG    SE++   T   A  +P  
Sbjct: 13339 IRCNMKLV---PELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTM 13395

Query: 866   TLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDL 925
              L    ++ L+    +P   LV +   P    +    +   + +T   V   T+    +L
Sbjct: 13396 DLSAF-KDGLEVIVPNPITILVPSTGYP--RPTATWCFGDKVLETGDRVKMKTLSAYAEL 13452

Query: 926   L-------PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW 978
             +        +  Y ++++   +  +G     + A+    P  P  L+       S+ L W
Sbjct: 13453 VISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR----PSAPKELKFGDITKDSVHLTW 13508

Query: 979   ------GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
                   G S    +  E    + +   +   F++        + V  L +   Y F++ A
Sbjct: 13509 EPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT-----DLEFTVPDLVQGKEYLFKVCA 13563

Query: 1033  ASEAGEGP---FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
              ++ G G      E    ST  +VP   +  +      NS  + W+   +  G  +   +
Sbjct: 13564 RNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYI 13623

Query: 1090  QVLVGRESEYKQVYKGE---EATFQISGLQTNTDYRFRVCACRR 1130
                  R S+ K V  GE   E   +++GL+    Y +RV A  R
Sbjct: 13624 VERCPRGSD-KWVACGEPVAETKMEVTGLEEGKWYAYRVKALNR 13666



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 66/238 (27%), Positives = 107/238 (44%), Gaps = 17/238 (7%)

Query: 535   VKNLKRSTQY-KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             +KN++R T   K+++  SN  G     + ++     D+P  PT P+V   +  +   + W
Sbjct: 30688 MKNVQRKTHAGKYKVQLSNVFGTV---DAILDVEIQDKPDKPTGPIVIEALLKNSAVISW 30744

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCIST 652
              PP D+GGS I  Y++E  +   E  +W++  S  S T     +L     Y  R    +T
Sbjct: 30745 KPPADDGGSWITNYVVEKCEA-KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNT 30803

Query: 653   GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYS 707
              G    S+ L V ++ I       P   G+P    V      + W  PAS+ G ++  Y 
Sbjct: 30804 FG---ISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYY 30860

Query: 708   VEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 762
             +E  E +    ++       E   +V NL+ G  Y FRV+  N GG   +S++SE  T
Sbjct: 30861 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT 30918



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 171/823 (20%), Positives = 290/823 (35%), Gaps = 78/823 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG--EELE 339
             P+V +    ++ L+W  P+      + G +    Y + + +K  D  Y++  +      E
Sbjct: 29348 PRVVDTTKHSISLAWTKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 29401

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP-KLAHRSKSSLTLQ 398
               + DL+    Y  RV A+  +VKG      S            P  +LA   K ++T++
Sbjct: 29402 FTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIR 29459

Query: 399   WKAPIDNGSKITNY---LLEWDEGKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
               A +     ++     ++ W +   +   R     ++ +  L   K+       + + A
Sbjct: 29460 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 29519

Query: 454   RNDIGTSGYSQEVVCY-TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE 512
              N  G    +  V  Y T G  P +    ++       VT+ W  P       V  Y +E
Sbjct: 29520 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWEIPTIDGGAPVNNYIVE 29575

Query: 513   IQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
              +E                   +  L   T Y FR+   N  G   P E        + P
Sbjct: 29576 KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVP 29635

Query: 573   GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
               P + L    VT    ++ W+ P  +GGS +  Y+LE     +E     V    +  E+
Sbjct: 29636 LVPAK-LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 29694

Query: 633   TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPG---QCRPPRVL----GR 682
             T T L  G  Y  R    +  G S+  E   ++ V+ L + P       P + +    GR
Sbjct: 29695 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGR 29754

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
             P    + +    P + S         ++ E E V  E  H    + T+          + 
Sbjct: 29755 PVELVIPIAGRPPPAASWFFAGS---KLRESERVTVET-HTKVAKLTIRETTIRDTGEYT 29810

Query: 743   VRALNDGGYGPYSDVSEITTAAGPP-GQCKAPCISCTPDGCVLVGWESPD-SSGADISEY 800
             +   N  G    +    I    GPP G  K   I  T    + + WE P+   GA +S Y
Sbjct: 29811 LELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDAT---SITISWEPPELDGGAPLSGY 29867

Query: 801   RLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY--SELVLCQT 856
              +E  +      L +    T + F+   L    +Y  R+ A N+ G G Y  SE++ C++
Sbjct: 29868 VVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS 29927

Query: 857   PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID----LGDTS 911
                 P P  TL +          D     + L W  P  + GS++  Y ++      D  
Sbjct: 29928 SIRIPGPPETLQIF---------DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 29978

Query: 912   ITVGNT----TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR------PLPPLP 961
             + V       T +    L     Y  R+ AIN  G+G  S+  K          P  P  
Sbjct: 29979 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQN 30038

Query: 962   PRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLT 1021
             PR+        SL     +    +     ++   +++       +        Y +  L 
Sbjct: 30039 PRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLP 30098

Query: 1022  EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQ 1064
             +   Y FR+ A +  G G  +E         VP T+K   + +
Sbjct: 30099 QGAEYRFRVLACNAGGPGEPAE---------VPGTVKVTEMLE 30132



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 195/894 (21%), Positives = 321/894 (35%), Gaps = 81/894 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+V ++   +V LSW+ P        +G       E +     R  K +I  +       
Sbjct: 30336 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERK-ETSTDKWVRHNKTQITTT----MYT 30390

Query: 342   LKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  L P  +Y  R+ A  +   S     SEPV        P  P   ++   SK S+TLQ
Sbjct: 30391 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 30450

Query: 399   WKAP-IDNGSKITNYLLEW----DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
             W+ P  D G +I  Y +E+    D   + S   +      K   +  L  A  Y FR+ A
Sbjct: 30451 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFA 30507

Query: 454   RNDIGTSGYSQEVVCY----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
              N+ G S   +  +      T G  P +    + V   +        +  G    ++  Y
Sbjct: 30508 ENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWY 30567

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
                 +E      +     G   T TV   ++  +  +   A+N  G+   S  L+   +P
Sbjct: 30568 RFG-KELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP 30626

Query: 570   D-RPGPPTRPLVKGPVTS----HGFSVKWDPPKDNG--GSEILKYLLEITDGNSEANQWE 622
                PG P +    G V S    H   +    P      G ++L+    IT  N+E     
Sbjct: 30627 QFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEH---- 30682

Query: 623   VAYSGSATEYTFTHLKPGTLY------KLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
                        +THL    +       K +    +  G       + ++     P +   
Sbjct: 30683 -----------YTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD---KPDKPTG 30728

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE---CTVGNL 733
             P V+         + W  PA + G  ++ Y VE  E ++ A        +    C + NL
Sbjct: 30729 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 30788

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISC-TPDGCVLVGWES 789
                  Y FRV A N  G     +VS +     P   PG    P I+  T D CV V W+ 
Sbjct: 30789 TENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCV-VAWKP 30847

Query: 790   PDS-SGADISEYRLEWGEDEESLELIYHGTDTR---FEIRDLLPAAQYCCRLQAFNQAGA 845
             P S  GA I  Y LE  E +++  +     + R   F +++L+   +Y  R++  N  G 
Sbjct: 30848 PASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGE 30907

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEE-EPLDAYPDSPS--ACLVLNWEEPC----NNGS 898
               +SE+    TP S   P+      EE   L+    S +   C V    +P       G 
Sbjct: 30908 SEWSEISEPITPKS-DVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGK 30966

Query: 899   EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP 958
             EI+A  +         G   + ++  +  +     +++A N+ G+   +  ++ +     
Sbjct: 30967 EIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKI 31025

Query: 959   PLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQ----LEDRNKRFISIYRGPSHT 1014
              LP  LE   A   +L+ +            D V T Q    L D N  +  I      +
Sbjct: 31026 HLPKTLEGMGA-VHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS 31084

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
                    E     F +  A     G   +T        VP   +  +V+ +  +S  + W
Sbjct: 31085 LVFPNGVERKDAGFYVVCAKNR-FGIDQKTVELDVA-DVPDPPRGVKVSDVSRDSVNLTW 31142

Query: 1075  ETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                 S  G  + NYI++        + +V +  E  + +  L   T Y+FRV A
Sbjct: 31143 TEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIA 31196



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 141/629 (22%), Positives = 239/629 (37%), Gaps = 64/629 (10%)

Query: 446   GYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITW--VTLQWSKPEGCSP 503
             G  + L A N  G+  +   V      + P  P  P  V  G+T    +L WS P     
Sbjct: 23693 GGQYILRASNVAGSKSFPVNVKVL---DRPGPPEGPVQV-TGVTSEKCSLTWSPPLQDGG 23748

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTEGKSCPSE 561
              ++  Y +E  + E   L       E +T ++K   L    +Y FR+ A N  G   P E
Sbjct: 23749 SDISHYVVE--KRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLE 23806

Query: 562   VL-VCTTSPD-RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
                V   +P   PGPP + L    +     +V W+ P  +GGSEI+ Y++E  D +    
Sbjct: 23807 SAPVLMKNPFVLPGPP-KSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI-- 23863

Query: 620   QWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLPVRTLS---IAPGQC 674
             +W        T+     T L     Y+ R    +  G  + S +            PG  
Sbjct: 23864 RWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPP 23923

Query: 675   RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPE-LECT---V 730
                 ++   K+  + L W  P  + G E+  Y VE+ + ++   ++      L  T   +
Sbjct: 23924 TNAHIVDTTKNS-ITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEI 23982

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD---GCVLVGW 787
               L     Y+ RV ALN  G G   + + +     P  + +AP +    +   G V+   
Sbjct: 23983 SKLTEHQEYKIRVCALNKVGLG---EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAG 24039

Query: 788   ESP----DSSGADISE--YRLEWGE--DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA 839
              S        G    E  +  E GE  D+  +E   + T    +  D   A +Y  +L+ 
Sbjct: 24040 GSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLEN 24099

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGS 898
                  +G  S  V  +     P P   L V E     A+         L WE P  + G+
Sbjct: 24100 ----SSGSKSAFVTVKV-LDTPGPPQNLAVKEVRKDSAF---------LVWEPPIIDGGA 24145

Query: 899   EILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIK 951
             ++  Y ID  +++        +  + T   +++L     Y  R+ A NE G G   + + 
Sbjct: 24146 KVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVD 24205

Query: 952   AKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR-NKRFISIYR 1009
             A     PP PP ++        S  L W +       +  + Y ++++ +  +++  +  
Sbjct: 24206 AVKAAEPPSPPGKVTLTDVSQTSASLMW-EKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE 24264

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGE 1038
                    V  L+    Y FR++A +E G+
Sbjct: 24265 SKVCNAVVTGLSSGQEYQFRVKAYNEKGK 24293



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 38/292 (13%)

Query: 888   LNWEEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKDLLPE------------TTYRIR 934
             L WEEP  +G S+I+ Y ++  D    +   T  +  D                  Y  R
Sbjct: 13108 LAWEEPLTDGGSKIIGYVVERRD----IKRKTWVLATDRAESCEFTVTGLQKGGVEYLFR 13163

Query: 935   IQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAED 990
             + A N +G G   +    ++A+++   P PP  +         + L W +       AE 
Sbjct: 13164 VSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTW-EPPEYDGGAEI 13222

Query: 991   IVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG------PF 1041
               Y ++L D+           R    +  V  + E   YSFR++A +  G G      PF
Sbjct: 13223 TNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPF 13282

Query: 1042  SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLV-GRESEY 1099
              +        S P  + +   TQ   +S ++ WE      G P+  YI++    G+++  
Sbjct: 13283 VKVADPIERPSPPVNLTSSDQTQ---SSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWI 13339

Query: 1100  KQVYK-GEEATFQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFV 1149
             +   K   E T++++GL+    Y +RV A  +  +    E+ G  +   AFV
Sbjct: 13340 RCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFV 13391



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 28/75 (37%), Positives = 36/75 (48%), Gaps = 1/75 (1%)

Query: 688   VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V+L W  PAS+ G +++ Y VE      +    V    E   TV NL   T Y+FRV A 
Sbjct: 31138 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 31197

Query: 747   NDGGYGPYSDVSEIT 761
             N  G    S+ SE T
Sbjct: 31198 NKFGLSKPSEPSEPT 31212



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 3/91 (3%)

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             D P PP R +    V+    ++ W  P  +GGS+I  Y++E     + A +W        
Sbjct: 31120 DVPDPP-RGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE--KCATTAERWLRVGQARE 31176

Query: 630   TEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             T YT  +L   T Y+ R    +  G S+ SE
Sbjct: 31177 TRYTVINLFGKTSYQFRVIAENKFGLSKPSE 31207



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 379   PECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P+ P   K++  S+ S+ L W  P  D GSKITNY++   E    +  R    G  +  +
Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIV---EKCATTAERWLRVGQARETR 31178

Query: 438   LT--KLCPAMGYTFRLAARNDIGTSGYSQ 464
              T   L     Y FR+ A N  G S  S+
Sbjct: 31179 YTVINLFGKTSYQFRVIAENKFGLSKPSE 31207



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 1/101 (0%)

Query: 461   GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
             G  Q+ V   + ++P  P   ++       V L W++P      ++  Y +E      + 
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 31167

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
                     E    TV NL   T Y+FR+ A N  G S PSE
Sbjct: 31168 WLRVGQARET-RYTVINLFGKTSYQFRVIAENKFGLSKPSE 31207


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  162 bits (410), Expect = 2e-39
 Identities = 201/810 (24%), Positives = 324/810 (40%), Gaps = 96/810 (11%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
            P PP    +   +  S  L W  P D+G SKITNY++E          +        + K
Sbjct: 7479 PGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 7538

Query: 438  LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQ 494
             TKL P   Y FR+AA N  G  G   +    T       P  P RL  + IT   VTL 
Sbjct: 7539 ATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLT 7597

Query: 495  WSKPEGCSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
            W +P+      +  Y +E  + + D      K   +D T  VK L    +Y+FR+ A N 
Sbjct: 7598 WCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENL 7657

Query: 554  EGKSCPS---EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             G   PS   E ++     D P PP +P VK  V      + W  P+ +GG++I  Y++E
Sbjct: 7658 AGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIESYVIE 7716

Query: 611  ITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPV--RT 666
            +    ++  +W  VA     T++    L  G  Y  R   ++  G S+ SE S PV  R 
Sbjct: 7717 MLKTGTD--EWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCRE 7774

Query: 667  LSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP-- 724
                P   R   V+   K+    L+W VP  + G  ++ Y VE  +      +       
Sbjct: 7775 KLYPPSPPRWLEVINITKNT-ADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVK 7833

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDG 781
            + +CTV  L  G++Y FRV A N  G   Y+++ +   A      PG   A  +      
Sbjct: 7834 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKR 7893

Query: 782  CVLVGWESPDSSGA-DISEYRLEWGEDEESLELIY------HGTDTRFEIRDLLPAAQYC 834
             V + WE P + G   I  Y +E    +E L   +       G D  F + D++   +  
Sbjct: 7894 HVDLKWEPPKNDGGRPIQRYVIE---KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQ 7950

Query: 835  CRLQAFNQAGAGPYSE---LVLCQTPASAPDPVSTLCVLEEEPLDAY-PDSPSACLVLNW 890
             +++A N+AG G  SE   ++  + P S P P          PLD +  D+    + + W
Sbjct: 7951 FQVRAENEAGVGHPSEPTEILSIEDPTSPPSP----------PLDLHVTDAGRKHIAIAW 8000

Query: 891  EEP-CNNGSEILAYTIDLGDT---------SITVGNTTMHVMKDLLPETTYRIRIQAINE 940
            + P  N GS I+ Y +++            S  + +    V + ++P+  Y +R++A+N 
Sbjct: 8001 KPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNA 8060

Query: 941  IGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH-----AAEDIVYTL 995
            IG    S+  +      P   P ++                  +TH       E +   +
Sbjct: 8061 IGVSEPSEISENVVAKDPDCKPTIDL-----------------ETHDIIVIEGEKLSIPV 8103

Query: 996  QLEDRNKRFISIYRGPSHTYKVQRLT---EFTCYSFRIQAASEAGEGPFS---ETYTFST 1049
                     +S ++         RLT   +       +  +  A  G ++   E    S 
Sbjct: 8104 PFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 8163

Query: 1050 TKSV-------PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQ 1101
            T S+       P   K  + + +  +SC++ WE      G P+ +Y+L+        Y  
Sbjct: 8164 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8223

Query: 1102 VYKGE-EATFQISGLQTNTDYRFRVCACRR 1130
            V  GE + ++ +  L  N +Y FRV A  +
Sbjct: 8224 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8253



 Score =  157 bits (396), Expect = 8e-38
 Identities = 220/917 (23%), Positives = 369/917 (40%), Gaps = 77/917 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D     +  +V  +   +V L+W PP+        G S   +Y V   +  R     
Sbjct: 15642 RVLDTPGPPQDLKVKEVTKTSVTLTWDPPL------LDGGSKIKNYIVEKRESTRKAYST 15695

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             +  +  +    +  L+    Y+ RV A      G  +E       S  P  P    L   
Sbjct: 15696 VATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDV 15755

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W+ P  D GS+I  Y++E  + K +  +  C         +T L     Y+F
Sbjct: 15756 TRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSF 15814

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT---LQWSKPEGCSPEEV 506
             R++A+N+ G S   Q  V     ++  +P A +L+    T +    L+   P    P   
Sbjct: 15815 RVSAQNEKGISDPRQLSVPVIAKDLV-IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPA 15873

Query: 507   ITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT 566
             +T+  +    +     + + T  +   T+K+  R     + +  +N+ G++  +  ++  
Sbjct: 15874 VTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVL 15933

Query: 567   TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
                D+PGPPT P+    VT+   ++ W PPK +GGS I  Y++E  D  +    W++  +
Sbjct: 15934 ---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRD--TSTTTWQIVSA 15988

Query: 627   GSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP-- 683
               A T      LK G  Y+ R    +  G S    S P    ++A    + P   G P  
Sbjct: 15989 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEP----TVAQYPFKVPGPPGTPVV 16044

Query: 684   ---KHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGT 737
                    + ++W+ P S+ G  V  Y +E  E   +     +    P+ +     L  G 
Sbjct: 16045 TLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGV 16104

Query: 738   VYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SS 793
              Y FRV A N  G G  S VSE   A     PPG+ +A  ++      V + W+ P    
Sbjct: 16105 EYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVT---RNSVTLQWKKPTYDG 16161

Query: 794   GADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRLQAFNQAG------ 844
             G+ I+ Y +E  E  E   +    T   DT FE+  L+   +Y  R+ A N AG      
Sbjct: 16162 GSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPS 16221

Query: 845   --AGPYSELVLCQTPASAPDP--VSTLCVLEEEPL----DAYPDSPSACLVLNWEEPCNN 896
                G  +       P  + DP    T+ V   E      D Y         +  ++  +N
Sbjct: 16222 ESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN 16281

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
              + +   + D   TS++V        KD +   +    ++A N  G    +  +K   RP
Sbjct: 16282 TARLEIKSTDFA-TSLSV--------KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 16332

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY- 1015
              PP  P +  +    +   L W     +   ++ I Y ++  + ++   ++      T  
Sbjct: 16333 GPPEGP-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLS 16390

Query: 1016  -KVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
              KV +L E   Y+FRI A ++ G G    SE         VP   KAP VT +  +S  +
Sbjct: 16391 CKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIV 16450

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACR 1129
             +WE   S  G  +  Y+L+        + + +K    E   +++GL  N DY FRV A  
Sbjct: 16451 VWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA-- 16508

Query: 1130  RCLDTSQELSGAFSPSA 1146
                + +  LS    PSA
Sbjct: 16509 ---ENAAGLSEPSPPSA 16522



 Score =  156 bits (395), Expect = 1e-37
 Identities = 223/898 (24%), Positives = 352/898 (39%), Gaps = 90/898 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS++ A + VLSW  P         G +   +Y V   + G      +  S +  +  +
Sbjct: 22444 EVSSVSAESCVLSWGEP------KDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKV 22497

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L    +Y  RV +   +   K   S P+        P  P  P++ H S ++++++W+
Sbjct: 22498 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22557

Query: 401   API-DNGSKITNYLLEWDEGKRNSGFRQ----CFFGSQKHCKLTKLCPAMGYTFRLAARN 455
              P  D GSKI  Y +E  E       ++    C    + + K+T L   + Y FR  A N
Sbjct: 22558 EPYHDGGSKIIGYWVEKKERNTILWVKENKVPCL---ECNYKVTGLVEGLEYQFRTYALN 22614

Query: 456   DIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE--- 512
               G S  S+        N    P  P +     + V+L WS P      +V+ Y +E   
Sbjct: 22615 AAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKP 22674

Query: 513   IQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPSEVLVCTTSPD 570
             + E  +       YT   D   TV  L     Y+FR+ A N  G  S  SE     T  D
Sbjct: 22675 VSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRD 22734

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKD------NGGSEILKYLLEITDGNSEANQWE-- 622
                PP   L       HG  V      D       GG    K +   T G+ E +  E  
Sbjct: 22735 EYAPPKAEL---DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIW--TKGDKELDLCEKV 22789

Query: 623   -VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
              + Y+G                K      +  G    + S+ V+ L  +PG C    V  
Sbjct: 22790 SLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTK--AVSVMVKVLD-SPGPCGKLTV-S 22845

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG--PELECTVGNLLPGTVY 739
             R   ++  L W +P  + G E++ Y VE  E   +   +  G  P L   V  L+    Y
Sbjct: 22846 RVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22905

Query: 740   RFRVRALNDGGYGPYSDVSEIT-----TAAGPPGQCKAPCISCTPDGCVLVGWESPDSSG 794
              FRVRA+N  G G   +   I      T   PPG    P    T    +++ W  P+S G
Sbjct: 22906 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG---IPEEVGTGKEHIIIQWTKPESDG 22962

Query: 795   A-DISEYRLEWGEDEE----SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
               +IS Y ++  E +      +   Y   DTR ++  L+    Y  R+ A N AG    S
Sbjct: 22963 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 23022

Query: 850   E---LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTI 905
             E    + C+ P+  P P S   V+         D+    + L W +P  + G++I+ Y +
Sbjct: 23023 EASNFISCREPSYTPGPPSAPRVV---------DTTKHSISLAWTKPMYDGGTDIVGYVL 23073

Query: 906   DLGD----------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR 955
             ++ +          T+ T+ NT   V  DL     Y  R+ A+N  G   +S+ I A+  
Sbjct: 23074 EMQEKDTDQWYRVHTNATIRNTEFTV-PDLKMGQKYSFRVAAVNVKGMSEYSESI-AEIE 23131

Query: 956   PLPPLP-PRLECAAAGPQSLKLKWGDS-----NSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
             P+  +  P LE A    +++ ++ G S     +        I ++ Q  D   R I    
Sbjct: 23132 PVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTT 23191

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                    V ++  +    + I+A +++G+   +       T    P++K   V++   +S
Sbjct: 23192 ESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR---DS 23248

Query: 1070  CEILWETVPSMKGDPV-NYILQVLVGRESEYKQV-YKGEEATFQISGLQTNTDYRFRV 1125
               I WE      G PV NYI++        +K V  K  +  ++ISGL   T Y FRV
Sbjct: 23249 VTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23306



 Score =  151 bits (382), Expect = 3e-36
 Identities = 213/899 (23%), Positives = 335/899 (37%), Gaps = 85/899 (9%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE--- 337
             +P+V ++ A A+ + W  P       H G S    Y V   ++       I++  E    
Sbjct: 22541 RPEVYHVSANAMSIRWEEPY------HDGGSKIIGYWVEKKERNT-----ILWVKENKVP 22589

Query: 338   -LECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSS 394
              LECN K   L    +Y  R YA+  +     SE           + P  P++   ++S+
Sbjct: 22590 CLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST 22649

Query: 395   LTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFR--QCFFG--SQKHCKLTKLCPAMGYTF 449
             ++L W AP  D GSK+  Y++E          R  +C +   S     +T L     Y F
Sbjct: 22650 VSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEF 22709

Query: 450   RLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPRL------VRAGITWVTLQWSKPE 499
             R+ A+N  G      E    V C      P+     RL      +RAG   V        
Sbjct: 22710 RVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVL---DAAV 22766

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             G  PE  I +T   +E +       +YTG+  T  +K   RS   K+ LT  N  G    
Sbjct: 22767 GGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAV 22826

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
             S ++    SP     P   L    VT    ++ W  P+++GG+EI  Y++E  +  S  N
Sbjct: 22827 SVMVKVLDSPG----PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRE-TSRLN 22881

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPP 677
                V        Y  T L     Y  R   ++  G     ES P+  R     P     P
Sbjct: 22882 WVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIP 22941

Query: 678   RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTVGNL 733
               +G  K + + ++W  P S+ G E+S Y V+  E + +     ++ Y   +    V +L
Sbjct: 22942 EEVGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSL 23000

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESP 790
             + G  Y+FRV A+N  G    S+ S   +   P   PG   AP +  T    + + W  P
Sbjct: 23001 MEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKP 23060

Query: 791   -DSSGADISEYRLEWGEDEESLELIYHGT----DTRFEIRDLLPAAQYCCRLQAFNQAGA 845
                 G DI  Y LE  E +       H      +T F + DL    +Y  R+ A N  G 
Sbjct: 23061 MYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGM 23120

Query: 846   GPYSELVLCQTPAS---------APDPVSTLCVLEEEPLDAYPD-SPSACLVLNWEEPCN 895
               YSE +    P           A D   T+ +     L      S     V+ W +   
Sbjct: 23121 SEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSK--- 23177

Query: 896   NGSEILAYTIDLGDTSI--TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                      IDL   +I  T  + ++ ++  +      +  I+A N+ G    +  +K  
Sbjct: 23178 -------QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVY 23230

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH 1013
               P P   P ++       S+ + W        A  +     + E   + F ++    S 
Sbjct: 23231 DTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK 23288

Query: 1014  T-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T Y++  L E T Y FR+   +  G G   ET        VP       V  +  ++  +
Sbjct: 23289 TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTL 23348

Query: 1073  LWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQ--ISGLQTNTDYRFRVCA 1127
              WE  P   G      Y+L+        + +V   +    +  ++ L     Y FR+ A
Sbjct: 23349 AWEK-PLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 23406



 Score =  151 bits (381), Expect = 4e-36
 Identities = 204/888 (22%), Positives = 355/888 (39%), Gaps = 68/888 (7%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P V+N+   ++ + W  PV       +G S    Y + + D+         K++      
Sbjct: 20371 PWVTNVTRESITVGWHEPVS------NGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHF 20424

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  +  +     Y  RVYA   +  G  S P        A E P   ++   SK+S++L 
Sbjct: 20425 K--VTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLS 20482

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W+ P  D GSKIT Y++E  +       +  F   ++    ++ L     Y FR+ ARN 
Sbjct: 20483 WQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNA 20542

Query: 457   IGTSGYSQEVV----CYTL--GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYT 510
             +G+     EVV    C     G +  +P     V       +++        P   I + 
Sbjct: 20543 VGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 20602

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
              + +E + + L   + T +  +  +K+  R     + L   N  G +  +   +     D
Sbjct: 20603 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT---IRVQILD 20659

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
             +PGPP  P+    VT+   ++ W PP D+GG++I  Y++E  +  S      V+      
Sbjct: 20660 KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRE-TSRVVWSMVSEHLEEC 20718

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQC--SESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
               T T +  G  Y  R   ++  G  +   S+S+  +   + PG    P V    K+  +
Sbjct: 20719 IITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKN-SM 20777

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPGTVYRFRV 743
              + W  P ++ G ++S Y +E  + +      V  E       + T   L   + Y++RV
Sbjct: 20778 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVT--GLTENSDYQYRV 20835

Query: 744   RALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISE 799
              A+N  G GP+S+ SE   AA    PPG      I+ +    + +GW  P    G+ ++ 
Sbjct: 20836 CAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTG 20895

Query: 800   YRLE--WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAGAG---PYSELV 852
             Y +E   GE+EE   +   G    T + + +L P   Y  R+ A N AG G     +E V
Sbjct: 20896 YVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPV 20955

Query: 853   LCQTPASAPD-------PVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
               +    AP+         S +    E+     P        + W +   N      Y+I
Sbjct: 20956 QAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSI 21015

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             +  D+S      ++  +  +    T +  +   N +G  P S  +  K    P    +L+
Sbjct: 21016 ENTDSS------SLLTIPQVTRNDTGKYILTIENGVGE-PKSSTVSVKVLDTPAACQKLQ 21068

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI--YRGPSHTYKVQRLTEF 1023
                    ++ L W D       +  I Y ++  D  KR  S+  ++  S ++K+  L+E 
Sbjct: 21069 VKHVSRGTVTLLW-DPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21127

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             T + FR+ A +E G G   ET        VP  I+   +      S  + W T P   G 
Sbjct: 21128 TPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW-TKPDFDGG 21186

Query: 1084  PVNYILQVLVGRESEYKQVYK----GEEATFQISGLQTNTDYRFRVCA 1127
              V  I + +V R+ + +Q +      +    ++S L+  +   FRV A
Sbjct: 21187 SV--ITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFA 21232



 Score =  147 bits (372), Expect = 5e-35
 Identities = 194/806 (24%), Positives = 311/806 (38%), Gaps = 94/806 (11%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++S+TLQWK P  D GSKIT Y++E  E       +  F      
Sbjct: 16134 CDP--PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDT 16191

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPR-----LVR 485
             H ++T L     Y FR+ ARN  G      E    +      + P++   P+     +V 
Sbjct: 16192 HFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH 16251

Query: 486   AGITWV-----------TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG ++            T+QW K +              QE  N      K T    + +
Sbjct: 16252 AGESFKVDADIYGKPIPTIQWIKGD--------------QELSNTARLEIKSTDFATSLS 16297

Query: 535   VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD 594
             VK+  R     + L A N  G+     V V     DRPGPP  P+V   VT+   ++ W 
Sbjct: 16298 VKDAVRVDSGNYILKAKNVAGER---SVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWK 16354

Query: 595   PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT-EYTFTHLKPGTLYKLRACCISTG 653
             PP  +GGS+I+ Y++E  + +     W V  +   T     T L  G  Y  R   ++  
Sbjct: 16355 PPLQDGGSDIINYIVERRETSRLV--WTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKY 16412

Query: 654   GHSQCSESLPV--RTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV  +   + P   + P V    K   + + W+ PAS+ G E+  Y +E  
Sbjct: 16413 GVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI-VVWERPASDGGSEILGYVLEKR 16471

Query: 712   EPEDVASEVYHGP---ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP-- 766
             + E +     H     EL   V  L+    Y FRV A N  G    S  S    A  P  
Sbjct: 16472 DKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 16531

Query: 767   -PGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE---DEESLELIYHGTD-T 820
              PG    P +       V + W  P    G +I  Y +E  +    E ++     G + T
Sbjct: 16532 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 16591

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
               E+  LL   +Y  R+ A N+AG G ++++   ++ +    APD    L + +   + A
Sbjct: 16592 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRA 16651

Query: 878   -------YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT 930
                     P        + W +      +     +    TS+ + N   +          
Sbjct: 16652 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRY------DSGK 16705

Query: 931   YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSK 984
             Y + +    E  +G  S F+  +    P  P  L+       S+ + W      G S  K
Sbjct: 16706 YTLTL----ENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16761

Query: 985   THAAEDIVYTLQLEDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              +  E      + E   K + ++      +++K+ +L E   Y FR+ A +E G G  ++
Sbjct: 16762 NYIVE------KREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 16815

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQ 1101
             T        VP       V  +  NS  + W T P   G    + YI+++      ++ +
Sbjct: 16816 TADPIKVAEVPQPPGKITVDDVTRNSVSLSW-TKPEHDGGSKIIQYIVEMQAKHSEKWSE 16874

Query: 1102  VYKGEEATFQISGLQTNTDYRFRVCA 1127
               + +     I+ L    +Y FRV A
Sbjct: 16875 CARVKSLQAVITNLTQGEEYLFRVVA 16900



 Score =  147 bits (372), Expect = 5e-35
 Identities = 204/794 (25%), Positives = 309/794 (38%), Gaps = 69/794 (8%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++++TL+WK P  D GSKIT Y++E  +       +  F    + 
Sbjct: 18298 CDP--PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLET 18355

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVR 485
                ++ L     Y FR+ ARN  G     S  S  +      + P     P+     +V 
Sbjct: 18356 EFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVH 18415

Query: 486   AGITWVT-----------LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG T+V            + WSK +G   EE     +EI           K T +  T  
Sbjct: 18416 AGETFVLEADIRGKPIPDVVWSK-DGKELEETAA-RMEI-----------KSTIQKTTLV 18462

Query: 535   VKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             VK+  R+   ++ L  SN  G KS P  V V     DRPGPP  PL    VT+    + W
Sbjct: 18463 VKDCIRTDGGQYILKLSNVGGTKSIPITVKVL----DRPGPPEGPLKVTGVTAEKCYLAW 18518

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTG 653
             +PP  +GG+ I  Y++E  +  S  +  +V+    A  Y  T L PG  Y  R   ++  
Sbjct: 18519 NPPLQDGGANISHYIIEKRE-TSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18577

Query: 654   GHSQCSESLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV   +    PG    P V    K   V + W  P  + G E+  Y +E  
Sbjct: 18578 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMV-VTWARPVDDGGTEIEGYILEKR 18636

Query: 712   EPEDVASEVYHG---PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG--- 765
             + E V     +     +L   V  L  G  Y FRV A N  G G  S+ S    A     
Sbjct: 18637 DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALY 18696

Query: 766   PPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGE---DEESLELIYHGTD-T 820
             PPG    P ++ T    V + W  P    GA +  Y +E  E   DE +      G    
Sbjct: 18697 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGK 18756

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
             +F +  L    +Y  R+ A N  G G  + L   V+ Q     P+      + +   L A
Sbjct: 18757 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 18816

Query: 878   YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQA 937
                      +    EP     +      D     +T  + TM V+ ++    + R  +  
Sbjct: 18817 SATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-SSFTMLVIDNVTRFDSGRYNLTL 18875

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQL 997
              N   +G  + F+  +    P  P  L        S+ L W        A        + 
Sbjct: 18876 EN--NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 18933

Query: 998   EDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT 1056
             E   K + +I       T++++ L E   Y FR+ A++E G G  +E  T    K   P 
Sbjct: 18934 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAE--TTEPVKVSEPP 18991

Query: 1057  IKAPRVTQLE--GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQIS 1113
             +   RVT ++   N+  I WE   S  G  +  Y++++      ++    + +     IS
Sbjct: 18992 LPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATIS 19051

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y FRV A
Sbjct: 19052 GLTAGEEYVFRVAA 19065



 Score =  146 bits (368), Expect = 1e-34
 Identities = 220/960 (22%), Positives = 387/960 (40%), Gaps = 137/960 (14%)

Query: 249   RRARSSPKSNDSDLQEYELEVKRVQD------ILSGIEKP------QVSNIQARAVVLSW 296
             R + +   +N +D  +Y L ++ V        ++  ++ P       V ++   + VLSW
Sbjct: 19934 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 19993

Query: 297   APPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVY 356
               P      P        +Y +   +  +     +  +   L   + +L+    Y+ RV 
Sbjct: 19994 DVPENDGGAPVK------NYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVS 20047

Query: 357   AMYN---SVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKI 409
                     +     E V  T      E P PP+   +   SK S++L W  P  D GS+I
Sbjct: 20048 GENEFGVGIPAETKEGVKIT------EKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRI 20101

Query: 410   TNYLLE-WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVC 468
              +Y++E  ++G++N  + +C      H  ++ L     Y FR+ A N  G S   + ++ 
Sbjct: 20102 VHYVVEALEKGQKN--WVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLP 20159

Query: 469   YTLG--------NIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
               +         ++   PS    VRAG     L+   P    P   +T + +    +   
Sbjct: 20160 VLIKEQLEPPEIDMKNFPSHTVYVRAGSN---LKVDIPISGKPLPKVTLSRDGVPLKATM 20216

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLV 580
              F+ + T E+LT  +K    +   ++ +TA+N+ G +   +  +     DRPGPPT P+V
Sbjct: 20217 RFNTEITAENLTINLKESVTADAGRYEITAANSSGTT---KAFINIVVLDRPGPPTGPVV 20273

Query: 581   KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPG 640
                +T    ++KW+PPK +GGS++  Y+L +    S A   EV+ + + T      L  G
Sbjct: 20274 ISDITEESVTLKWEPPKYDGGSQVTNYIL-LKRETSTAVWTEVSATVARTMMKVMKLTTG 20332

Query: 641   TLYKLRACCISTGGHSQCSES--LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
               Y+ R    +  G S   +S  + V+     PG    P V    + + + + W  P S 
Sbjct: 20333 EEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTR-ESITVGWHEPVSN 20391

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDGGYGPYS 755
              G  V  Y +EM +   +  +  +   +  T   V  +  G +Y FRV A N  G G  S
Sbjct: 20392 GGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 20451

Query: 756   DVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEY---RLEWGEDE 808
               SE      A  PP   +   IS      V + W+ P    G+ I+ Y   R +  +  
Sbjct: 20452 HPSEPVLAIDACEPPRNVRITDIS---KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGR 20508

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL- 867
              +     + T+T+F I  L   +QY  R+ A N  G+           P+    P++ + 
Sbjct: 20509 WTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGS--------ISNPSEVVGPITCID 20560

Query: 868   --------CVLEEEPLDAYPDSPSACL----------VLNW----EEPCNNGSEILAYTI 905
                       LE   +  Y    S  L           + W    +E   N    +  T 
Sbjct: 20561 SYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTT 20620

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             DL   SI + +       D L    Y ++++  N +G+   +  ++   +P PP  P +E
Sbjct: 20621 DL--ASILIKDA------DRLNSGCYELKLR--NAMGSASATIRVQILDKPGPPGGP-IE 20669

Query: 966   CAAAGPQSLKLKW----GDSNSK-TH------AAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
                   + + L W     D  +K TH          +V+++  E   +  I+       T
Sbjct: 20670 FKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIIT-------T 20722

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV----PPTIKAPRVTQLEGNSC 1070
              K+ +  E   Y FR++A ++ G G   E+ +     +     PP I  P VT++  NS 
Sbjct: 20723 TKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI--PEVTKITKNSM 20777

Query: 1071  EILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              ++W    +  G  ++ Y L+    +   + +V K    +   +++GL  N+DY++RVCA
Sbjct: 20778 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCA 20837



 Score =  145 bits (366), Expect = 2e-34
 Identities = 219/898 (24%), Positives = 343/898 (38%), Gaps = 89/898 (9%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             + P +SNI    + +SW PP      P +G         A++    + K  I     E  
Sbjct: 13187 DPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-----ERT 13241

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPEC----PFPPKLAHRSKSSL 395
                  L+  T+Y  RV A+  +  G  S+  S   ++  P+     P  PK+   ++SS+
Sbjct: 13242 LKATGLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13300

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG---SQKHCKLTKLCPAMGYTFRL 451
             +L W  P  D GS I  YL+E      ++  R C       +   ++T L     Y FR+
Sbjct: 13301 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR-CNLPQNLQKTRFEVTGLMEDTQYQFRV 13359

Query: 452   AARNDIGTSG--------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
              A N IG S         Y ++++    G +        ++RAG   VT++   P    P
Sbjct: 13360 YAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG---VTMRLYVPVKGRP 13416

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVL 563
                IT++       +      K T  D     +N+ +    K+ LT  N+ GK    E  
Sbjct: 13417 PPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGK---KEYT 13473

Query: 564   VCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE- 622
             +     D PGPP    VK  ++     V W+PP  +GGS I+ Y+++  D  +E   W  
Sbjct: 13474 IVVKVLDTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRD--AERKSWST 13530

Query: 623   VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             V    S T +   +L+ G  Y  R    +  G     E+      S  PG     +V   
Sbjct: 13531 VTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSV 13590

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
              K     + W  P S+ G  +  Y V+    E+    V     L+ +  +L  G  Y FR
Sbjct: 13591 SK-SSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFR 13649

Query: 743   VRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS---E 799
             V A N+ G G     SEIT  A          +   PD C L    S       I     
Sbjct: 13650 VSAENENGEG---TPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPA 13706

Query: 800   YRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPAS 859
               + W + E+ L      TDTR  +     A      +    ++ AG Y+  +  +  A 
Sbjct: 13707 PSVSWKKGEDPL-----ATDTRVSVES--SAVNTTLIVYDCQKSDAGKYT--ITLKNVAG 13757

Query: 860   APDPVSTLCVLEEEPLDAYP----DSPSACLVLNWEEPCNN-GSEILAYTIDLGDT---- 910
               +   ++ V+ +  +   P    +  +  + L W  P ++ GSEI  Y ++  D+    
Sbjct: 13758 TKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNK 13817

Query: 911   ----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG---PFSQFIKAKTRPLPPLPPR 963
                 +  V  TT  V + L     Y  R+ A N+ G G        +      +P  PP 
Sbjct: 13818 WVTCASAVQKTTFRVTR-LHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPP 13876

Query: 964   LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT------YKV 1017
                      S+ L W D   KT  +    Y L+ ++RN     +++  + T      +KV
Sbjct: 13877 PNIVDVRHDSVSLTWTDP-KKTGGSPITGYHLEFKERNS---LLWKRANKTPIRMRDFKV 13932

Query: 1018  QRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWET 1076
               LTE   Y FR+ A + AG G P   +        + P  K P V  +  NS  ++W T
Sbjct: 13933 TGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK-PEVINITRNSVTLIW-T 13990

Query: 1077  VPSMKGDP--VNYILQVLVGRESEYKQVYKGE-----EATFQISGLQTNTDYRFRVCA 1127
              P   G      YI++    R+   K   K       E  F ++ L     Y FR+ A
Sbjct: 13991 EPKYDGGHKLTGYIVE---KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRA 14045



 Score =  145 bits (366), Expect = 2e-34
 Identities = 216/907 (23%), Positives = 353/907 (38%), Gaps = 111/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P+V +     ++++W  PV      + G S    Y +   ++         KI+ +  ++
Sbjct: 19288 PKVVHATKSTMLVTWQVPV------NDGGSRVIGYHLEYKERSSILWSKANKILIADTQM 19341

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCS---EPVSFTTHSCAPECPFPPKLAHRSKSSL 395
             +  +  L     Y  RVYA   +  G CS   EPV      C P  P  P++ + ++ S+
Sbjct: 19342 K--VSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDP--PGQPEVTNITRKSV 19396

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYTFRLAA 453
             +L+W  P  D G+KIT Y++E  E       +  +   Q+ + ++T+L     Y FR+ A
Sbjct: 19397 SLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFA 19456

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGITWVTLQWSKPEGCS 502
             RN   +     E     +      P  PR+           V+AG     L+ +      
Sbjct: 19457 RNAADSVSEPSESTGPIIVKDDVEP--PRVMMDVKFRDVIVVKAG---EVLKINADIAGR 19511

Query: 503   PEEVITYT---LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             P  VI++    +EI+E     +     T      TVK+  R    ++ LT  N  G    
Sbjct: 19512 PLPVISWAKDGIEIEERARTEIIS---TDNHTLLTVKDCIRRDTGQYVLTLKNVAGTR-- 19566

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V V     D+PGPP  PL    +T+   S+ W  P+++GG++I  Y++E  + +  A 
Sbjct: 19567 -SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLA- 19624

Query: 620   QWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
              W +       T    T L  G  Y  R   ++  G  +  ES+ ++ L        P  
Sbjct: 19625 -WTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTS 19683

Query: 679   VLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDV------ASEVYHGPELECTVG 731
             +      KE + L W  P S+ G E+S Y +E  E   +         VY   +L     
Sbjct: 19684 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVY---DLRVKST 19740

Query: 732   NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWE 788
              L  G  Y +RV A N  G    S+ S +  A  P   P     P I  +    + + W 
Sbjct: 19741 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWV 19800

Query: 789   SP-DSSGADISEYRLEW--GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGA 845
              P    GA I+ Y +E+   +D +    I     T + I  L   A+Y  R+++ N+ GA
Sbjct: 19801 KPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 19860

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN---------------- 889
                        P+ + DP       EEEPL          L++                 
Sbjct: 19861 ---------SDPSDSSDP-QIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPV 19910

Query: 890   ----WEEPCNNGSEILAYTIDLGD--TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
                 W +P +      AY +D  D  TS+T+ N   +          Y + IQ  N + A
Sbjct: 19911 PNVLWSKP-DTDLRTRAY-VDTTDSRTSLTIENANRN------DSGKYTLTIQ--NVLSA 19960

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
                +  +K    P P  P  +       +S  L W    +   A     +  + E   K 
Sbjct: 19961 ASLTLVVKVLDTPGP--PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKA 20018

Query: 1004  FISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRV 1062
             ++S+    +  +YKV  L E   Y FR+   +E G G  +ET         P   +   V
Sbjct: 20019 WVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGV 20078

Query: 1063  TQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             T +  +S  + W   P   G    V+Y+++ L   +  + +    +     +SGL+ N++
Sbjct: 20079 TSISKDSVSLTW-LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSE 20137

Query: 1121  YRFRVCA 1127
             Y FRV A
Sbjct: 20138 YFFRVFA 20144



 Score =  145 bits (365), Expect = 3e-34
 Identities = 217/907 (23%), Positives = 339/907 (37%), Gaps = 109/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG------ 335
             P  + I   ++V+ W  PV     P  G    Y  E       R  +  I+++       
Sbjct: 17124 PFATAISKDSMVIQWHEPVNNGGSPVIG----YHLE-------RKERNSILWTKVNKTII 17172

Query: 336   EELECNLKDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
              + +   ++L    +Y  RVYA  +    K S +         C P  P  P+     ++
Sbjct: 17173 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRN 17230

Query: 394   SLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRL 451
              +TLQW  P+ D GS IT Y++E  +       +  F    +    ++ L     Y FR+
Sbjct: 17231 EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17290

Query: 452   AARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITWVTLQWSKPEGCS 502
              A+N  G     S  +  +       +P++   P+     +V AG T+   +        
Sbjct: 17291 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETF---RLEADVHGK 17347

Query: 503   PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSE 561
             P   I +    +E E       K T       VK+  R    ++ L ASN  G KS P  
Sbjct: 17348 PLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVN 17407

Query: 562   VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
             V V     DRPGPP  P+    VTS   S+ W PP  +GGS+I  Y++E  + +  A  W
Sbjct: 17408 VKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLA--W 17461

Query: 622   EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPR 678
              V  S   T     T L  G  Y  R   ++  G  +  ES PV  +   + PG  +   
Sbjct: 17462 TVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLE 17521

Query: 679   VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA---SEVYHGPELECTVGNLLP 735
             V    K   + + W+ P S+ G E+  Y VE  +   +           +L   V  L  
Sbjct: 17522 VTNIAKDS-MTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTE 17580

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESPD- 791
                Y FRV A N  G G  S  +    A  P   PG      I  T    + + W  P  
Sbjct: 17581 DHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIY 17640

Query: 792   SSGADISEYRLEWGE-DEESLELIYHGTD---TRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
               G++I  Y +E  + DEE  +++   T    TRFEI  L    +Y  R+ A N+ G G 
Sbjct: 17641 DGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE 17700

Query: 848   YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-------------------L 888
              +         S P  V     LE   LD   +     +V                   +
Sbjct: 17701 AT---------SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEI 17751

Query: 889   NWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
              W       ++ +     +  T +++ N       D      Y +++    E  +G  S 
Sbjct: 17752 TWSREEGEFTDKVQIEKGVNYTQLSIDNC------DRNDAGKYILKL----ENSSGSKSA 17801

Query: 949   FIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNK 1002
             F+  K    P  P  L        S  L W      G +  K +  +      + E   K
Sbjct: 17802 FVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID------KRESTRK 17855

Query: 1003  RFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR 1061
              + ++    S T +KV+ LTE   Y FR+ A +E G G   ET         P       
Sbjct: 17856 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17915

Query: 1062  VTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             +T +   S  ++WE      G  V  Y++++      ++  V + +     ++GL +  +
Sbjct: 17916 LTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQE 17975

Query: 1121  YRFRVCA 1127
             Y+FRV A
Sbjct: 17976 YQFRVKA 17982



 Score =  145 bits (365), Expect = 3e-34
 Identities = 190/781 (24%), Positives = 303/781 (38%), Gaps = 90/781 (11%)

Query: 361   SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEG 419
             +V G+ SE +             P K+     +S+T+ W+ P +D G+ ++ Y++E  + 
Sbjct: 23510 NVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDA 23569

Query: 420   KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVV--CYTLGNIPQM 477
              R          ++   K T+L     Y FR+AA N  G   Y Q  V  C +   IP  
Sbjct: 23570 HRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 23629

Query: 478   PSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT-CTVK 536
             P   ++       +TL W  PE     +V  Y +E +E   D           +T     
Sbjct: 23630 PETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRST 23689

Query: 537   NLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
              L    +Y+ R+TA N  G    S PS+ +V       PG P  P V    T    S+ W
Sbjct: 23690 GLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVT-DTTRTSVSLAW 23748

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYS--GSATEYTFTHLKPGTLYKLRACCIS 651
               P+D GGS++  YL+E+     + ++W    +      EYT THL  G  Y+ R    +
Sbjct: 23749 SVPEDEGGSKVTGYLIEMQ--KVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACN 23806

Query: 652   TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDVPASESGCEVSEYSVEM 710
              GG  + +E          PG  +   +L  P ++ +   +  +   + G  V   ++ +
Sbjct: 23807 AGGPGEPAE---------VPGTVKVTEMLEYPDYELDERYQEGIFVRQGG--VIRLTIPI 23855

Query: 711   T-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---------- 759
               +P  +      G ++          T     ++  + G  G Y  V E          
Sbjct: 23856 KGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYI 23915

Query: 760   ----ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELI 814
                 I +   P G  +   I       V V W  P D  GADI  Y L   E  E  +  
Sbjct: 23916 KVRVIGSPNSPEGPLEYDDIQVR---SVRVSWRPPADDGGADILGYIL---ERREVPKAA 23969

Query: 815   YHGTDTRFE-----IRDLLPAAQYCCRLQAFNQAGAG---PYSELVLCQTPASAPDPVST 866
             ++  D+R       ++ L    +Y  R+ A NQ G        E V  +TP + P+P S 
Sbjct: 23970 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSN 24029

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTSI--------TVGNT 917
                   E LD    S S    L+W  P ++ GS +  Y I+  +TS         T   T
Sbjct: 24030 ----PPEVLDVTKSSVS----LSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 24081

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTR-PLPPLPPRLECAAAGPQS 973
             TM+ +  L+P+  Y+ RI A N++G     P S+ +  K     P  P  LE  +    S
Sbjct: 24082 TMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDS 24141

Query: 974   LKLKWGDSNSKTHAAEDI----VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
             + L+W     +    ++I    V   Q  D   +  +  R     + +  L E T Y FR
Sbjct: 24142 VTLQW--EKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFR 24199

Query: 1030  IQAASEAG-EGPFSETYTFST--TKSVPPTIK------APRVTQLEGNSCEILWETVPSM 1080
             + A +E G   P     +  T  T    P I+        ++ +    SC+I+   +P +
Sbjct: 24200 VFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDI 24259

Query: 1081  K 1081
             K
Sbjct: 24260 K 24260



 Score =  144 bits (363), Expect = 5e-34
 Identities = 208/860 (24%), Positives = 341/860 (39%), Gaps = 95/860 (11%)

Query: 350   DYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSK 408
             +Y  R+YA+  +     S+P  + T     + P  P++   +KS+++L W  P  D GSK
Sbjct: 12856 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 12915

Query: 409   ITNYLLE-----WDEGKR-NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGY 462
             I  Y +E      D+  R N+   Q     Q+    T L     Y FR  AR  +  S  
Sbjct: 12916 IIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEEKAQYQFRAIARTAVNISPP 12972

Query: 463   SQ--EVVCYTLGNIPQMPSAPRL-VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND 519
             S+  + V     N+P     PR+ +   +  +    +    C    V    +     + D
Sbjct: 12973 SEPSDPVTILAENVP-----PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 13027

Query: 520   N-LFHP----KYTGEDLTCTVK--NLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDR 571
               L  P    K   +   CT++  ++ R     + +TA N+ G KS   ++ V     D+
Sbjct: 13028 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL----DK 13083

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP    +    +     + W+PP ++GGSEI  Y+++  +  S  N  +V+ +   T 
Sbjct: 13084 PGPPASVKINKMYSDRAM-LSWEPPLEDGGSEITNYIVDKRE-TSRPNWAQVSATVPITS 13141

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH 689
              +   L  G  Y+ R C  +  G      +E    +     PG+C PP V+       + 
Sbjct: 13142 CSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPP-VISNITKDHMT 13200

Query: 690   LEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECTVG--NLLPGTVYRFRVRAL 746
             + W  PA + G  ++ Y +E  E + V  ++V   P +E T+    L  GT Y FRV A+
Sbjct: 13201 VSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAI 13260

Query: 747   NDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL 802
             N  G G  SD S+   A     PPG    P +  T    V + W  P    G+ I  Y +
Sbjct: 13261 NKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLV 13320

Query: 803   EWGEDEES----LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
             E    +        L  +   TRFE+  L+   QY  R+ A N+ G   YS+      P+
Sbjct: 13321 EVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG---YSD------PS 13371

Query: 859   SAPDP--VSTLCVLEEEPLDA-----------------YPDSPSACLVLNWEEPCNNGSE 899
               PD      + +  E  LDA                  P        + W +P  N  +
Sbjct: 13372 DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD 13431

Query: 900   ILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
              +   +D+  T         +V K       Y + ++  N  G   ++  +K    P PP
Sbjct: 13432 RIG--LDIKSTDFDTFLRCENVNK--YDAGKYILTLE--NSCGKKEYTIVVKVLDTPGPP 13485

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED-RNKRFISIYRGPSHT-YKV 1017
             +   +        S  + W +       +  I Y +Q  D   K + ++    S T ++V
Sbjct: 13486 V--NVTVKEISKDSAYVTW-EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRV 13542

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETV 1077
               L E   Y FR+ A +E G G   ET         P  +   +V  +  +SC I W+  
Sbjct: 13543 ANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKP 13602

Query: 1078  PSMKGDP-VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQ 1136
              S  G   + Y++  L   E+++++V K     +    L    +Y FRV A        +
Sbjct: 13603 HSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA--------E 13653

Query: 1137  ELSGAFSPSAAFVLQRSEVM 1156
               +G  +PS   V+ R +V+
Sbjct: 13654 NENGEGTPSEITVVARDDVV 13673



 Score =  144 bits (363), Expect = 5e-34
 Identities = 211/906 (23%), Positives = 353/906 (38%), Gaps = 106/906 (11%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKII---YSGEE 337
             KP + N+ +  + L+W  PV      + G S    + V   ++      K+     SG E
Sbjct: 21457 KPVIYNVTSDGMSLTWDAPV------YDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 21510

Query: 338   LECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTL 397
                    L    DY  RVYA  ++   S S+P  FT      + P  P     ++ ++TL
Sbjct: 21511 YRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITL 21568

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
             +W  P+ D GSKI  Y +E  +G  N  + +C F     C+  +T L P   Y FR+ AR
Sbjct: 21569 KWNPPLRDGGSKIVGYSIEKRQG--NERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIAR 21626

Query: 455   NDIGT---SGYSQEVVCYTLGNIPQMPS-APR-----LVRAGITWVTLQWSKPEGCSPEE 505
             N +GT      S  ++     N+P +    P      ++++G +      +  +G     
Sbjct: 21627 NAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIK--ALVQGRPVPR 21684

Query: 506   VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             V  +   ++ ++  N+      G   +  V++  R  +  + + A N  G S  +E+ V 
Sbjct: 21685 VTWFKDGVEIEKRMNMEITDVLGST-SLFVRDATRDHRGVYTVEAKNASG-SAKAEIKVK 21742

Query: 566   TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VA 624
                 D PG    P+    +T    ++ WD P ++G + I  Y++E  + +  A  W  + 
Sbjct: 21743 VQ--DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLA--WALIE 21798

Query: 625   YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV-----RTLSIAPGQCRPPRV 679
                 A  YT   L  G  Y+ R   ++  G  +  +S PV      T+  APG   P  +
Sbjct: 21799 DKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI 21858

Query: 680   LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV--ASEVYHGP--ELECTVGNLLP 735
              G      + L W  P S+ G E+ +Y +E  E +       +   P  E    V  L  
Sbjct: 21859 TG----NSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTE 21914

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESP-D 791
             G  Y F V A N  G GP S +S +        PPG      ++ T    V + W  P  
Sbjct: 21915 GNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVF 21974

Query: 792   SSGADISEYRLEWGEDEESLELIYHGTD------TRFEIRDLLPAAQYCCRLQAFNQAGA 845
               G +I  Y +E  + +      +H  +      TR+ + DL    +Y  R+ A N AG 
Sbjct: 21975 DGGMEIIGYIIEMCKADLG---DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 22031

Query: 846   GPYSEL---VLCQTPASAPDPVSTLCVLEEEPLD---------AYPDSPSACLVLNWEEP 893
             G   E+   +      +AP+        +   +          AY   P+   V  W +P
Sbjct: 22032 GDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAV--WSKP 22089

Query: 894   CNNGSEILAYTIDLGDT----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
              +N    L+   D+  T    ++TV N   +          Y + ++  N  G+   +  
Sbjct: 22090 DSN----LSLRADIHTTDSFSTLTVENCNRN------DAGKYTLTVE--NNSGSKSITFT 22137

Query: 950   IKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDRNKRFI 1005
             +K    P PP P   +    G  S  L W     D  ++ H      Y ++  + ++R  
Sbjct: 22138 VKVLDTPGPPGPITFKDVTRG--SATLMWDAPLLDGGARIHH-----YVVEKREASRRSW 22190

Query: 1006  SIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRV 1062
              +   +     +KV  L E   Y FR+ A +E G G P+        T+   P  +   V
Sbjct: 22191 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLD-V 22249

Query: 1063  TQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDY 1121
                  +S  + W       G  +  Y+L++       + +    ++ TF +  L   T+Y
Sbjct: 22250 VDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEY 22309

Query: 1122  RFRVCA 1127
              FRV A
Sbjct: 22310 EFRVKA 22315



 Score =  143 bits (360), Expect = 1e-33
 Identities = 217/889 (24%), Positives = 336/889 (37%), Gaps = 142/889 (15%)

Query: 336  EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCA-----PECPFPPKLAHR 390
            E  +C++  L    +Y  RV A     K  C  PV             P  P       R
Sbjct: 8945 ERSKCDITGLLEGQEYKFRVIAKN---KFGCGPPVEIGPILAVDPLGPPTSPERLTYTER 9001

Query: 391  SKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPA 444
            +KS++TL WK P  NG S I  Y++E    KR          +++ C  T      L   
Sbjct: 9002 TKSTITLDWKEPRSNGGSPIQGYIIE----KRRHDKPDFERVNKRLCPTTSFLVENLDEH 9057

Query: 445  MGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQMPSAPRLVRA----------------- 486
              Y FR+ A N+IG S  S  + V      +P        VR                  
Sbjct: 9058 QMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADV 9117

Query: 487  -GITWVTLQWSKPEGC--SPEEVITYTLE--IQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
             G+    ++WSK E     P + +  T E   + +    L  PK   ED           
Sbjct: 9118 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED----------- 9166

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             +  + +TASN  G    +   V     DRP PP R L    + +    + WD P DNGG
Sbjct: 9167 -KGTYTVTASNRLGSVFRN---VHVEVYDRPSPP-RNLAVTDIKAESCYLTWDAPLDNGG 9221

Query: 602  SEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHS-QC- 658
            SEI  Y+++  D + +  +W EV  +     Y    L P   Y+ R   ++  G S +C 
Sbjct: 9222 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECK 9281

Query: 659  SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVA 717
            S+ + ++     PG    P+VL R K   + + W  P    G  ++ Y +E  E      
Sbjct: 9282 SDKVVIQDPYRLPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYWLEKREEGSPYW 9340

Query: 718  SEVYHGP-------ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG---PP 767
            S V   P        +E  V  LL G  Y+FR  A+N  G GP S+ S+   A     PP
Sbjct: 9341 SRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPP 9400

Query: 768  GQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGT 818
            G    P +       + +GW+ P    G+ I  Y +E        W    E  +LI   T
Sbjct: 9401 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI---T 9457

Query: 819  DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAY 878
                 + +L    +Y  R++A N+AG    S+    + PA+          ++EEP    
Sbjct: 9458 TCECVVPNLKELRKYRFRVKAVNEAGESEPSD-TTGEIPATD---------IQEEPEVFI 9507

Query: 879  PDSPSACLVLNWEEPCNNGSEILAYTIDLG---------------------------DTS 911
                  CLV      C  GS+I    +  G                           D  
Sbjct: 9508 DIGAQDCLV------CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQ 9561

Query: 912  I-TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAG 970
            + T  N+++ ++ +     T +  I A N+ G    +  +K    P PP   ++     G
Sbjct: 9562 LETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRG 9621

Query: 971  PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRI 1030
               L  K  D +        ++    ++ +    ++   G S T+ V  L     Y FR+
Sbjct: 9622 SCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG-STTFVVPDLLSEQQYFFRV 9680

Query: 1031 QAASEAGEGPFSETYTFSTTKS----VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV- 1085
            +A +  G GP  ET   +T +       P IK  ++  +  N+  + W+   +  G PV 
Sbjct: 9681 RAENRFGIGPPVETIQRTTARDPIYPPDPPIKL-KIGLITKNTVHLSWKPPKNDGGSPVT 9739

Query: 1086 NYILQVLV-----GRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
            +YI++ L       ++  ++Q  K   EE  F +  L    +Y FRV A
Sbjct: 9740 HYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9788



 Score =  142 bits (359), Expect = 1e-33
 Identities = 209/893 (23%), Positives = 365/893 (40%), Gaps = 77/893 (8%)

Query: 284  VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
            ++++   + +L+W PP         G S   +Y V       +  +K+  + ++      
Sbjct: 7487 ITDVTNESCLLTWNPP------RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKAT 7540

Query: 344  DLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L P  +Y  RV A  MY   +   + P++       P  P   + +  +K ++TL W  
Sbjct: 7541 KLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCE 7600

Query: 402  PIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHC--KLTKLCPAMGYTFRLAARNDIG 458
            P D+G S IT Y +E  +   +   R C     K    ++  L     Y FR+ A N  G
Sbjct: 7601 PDDDGGSPITGYWVERLDPDTDKWVR-CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAG 7659

Query: 459  T---SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                S  ++ ++     + P  P  P +   G T V L W+KPE     ++ +Y +E+ +
Sbjct: 7660 PGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLK 7719

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV---LVCTTSPDRP 572
               D               +  L    +Y FR+ A N  G+S PSE    ++C      P
Sbjct: 7720 TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPP 7779

Query: 573  GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
             PP R L    +T +   +KW  P+ +GGS I  Y++E  D   +  Q  V  +   T+ 
Sbjct: 7780 SPP-RWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQ-TVDTTVKDTKC 7837

Query: 633  TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPGQCRPPRVLG--RPKHKE 687
            T T L  G+LY  R    +  G S  +E   S+  +     PG   PP  L       + 
Sbjct: 7838 TVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPG---PPYALAVVDVTKRH 7894

Query: 688  VHLEWDVPASESGCEVSEYSVEMTE---PEDVASEVYHGPELECTVGNLLPGTVYRFRVR 744
            V L+W+ P ++ G  +  Y +E  E      V +    GP+    V +++ GT  +F+VR
Sbjct: 7895 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7954

Query: 745  ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC---VLVGWESPDSSGAD-ISEY 800
            A N+ G G  S+ +EI +   P      P      D     + + W+ P+ +G   I  Y
Sbjct: 7955 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 8014

Query: 801  RLEW---GEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             +E    G ++          D +F++ + ++P  +Y  R++A N  G    SE+   V+
Sbjct: 8015 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 8074

Query: 854  CQTPASAPD---PVSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
             + P   P        + V+E E L    P        ++W +   +G E+ A       
Sbjct: 8075 AKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHK---DGKEVKA------S 8125

Query: 910  TSITVGNTTMHVMKDL-LPETT------YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPP 962
              +T+ N   H+   L +P++       Y I ++  N++G+   S  I  K   LP    
Sbjct: 8126 DRLTMKND--HISAHLEVPKSVRADAGIYTITLE--NKLGSATAS--INVKVIGLPGPCK 8179

Query: 963  RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR-FISIYRGPSH-TYKVQRL 1020
             ++ +     S KL W +          + Y L+  +  +R +I +  G +  ++ V+ L
Sbjct: 8180 DIKASDITKSSCKLTW-EPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDL 8238

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCE---ILWETV 1077
                 Y FR++A ++ G G + E       +        P   ++   + E   I W+  
Sbjct: 8239 IPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP 8298

Query: 1078 PSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
                G  +  YI++ +   E  +K+  +      T+   GL+   +Y+FRV A
Sbjct: 8299 LYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRA 8351



 Score =  142 bits (359), Expect = 1e-33
 Identities = 212/900 (23%), Positives = 347/900 (38%), Gaps = 98/900 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +++ + +   +LSW PP+        G S   +Y V   +  R    ++  +     C++
Sbjct: 13091 KINKMYSDRAMLSWEPPL------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSV 13144

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
             + L    +Y  R+ A   Y       +EP         P    PP +++ +K  +T+ WK
Sbjct: 13145 EKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWK 13204

Query: 401   APIDN-GSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              P D+ GS IT YLLE        W +  R           ++  K T L     Y FR+
Sbjct: 13205 PPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-------ERTLKATGLQEGTEYEFRV 13257

Query: 452   AARNDIG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
              A N  G    S  S+          P  P+ P++     + V+L W KP       +I 
Sbjct: 13258 TAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIG 13317

Query: 509   YTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             Y +E++  ++DN        ++L  T   V  L   TQY+FR+ A N  G S PS+V   
Sbjct: 13318 YLVEVKRADSDNWVRCNLP-QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDK 13376

Query: 566   TTSPDRPGPPTRPL---------VKGPVTSHGF-SVKWDPPKDNGGSEILKYLLEITDGN 615
                 D   PP   L         ++  VT   +  VK  PP             +IT   
Sbjct: 13377 HYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP------------KITWSK 13424

Query: 616   SEAN-QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQC 674
                N +  +     +T++  T L+   + K  A        + C +      + +     
Sbjct: 13425 PNVNLRDRIGLDIKSTDFD-TFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13483

Query: 675   RPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---- 729
              P  V  +   K+  ++ W+ P  + G  +  Y V   +  D   + +     EC+    
Sbjct: 13484 PPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV---QKRDAERKSWSTVTTECSKTSF 13540

Query: 730   -VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE 788
              V NL  G  Y FRV A N+ G G   +  +   A+  PG      +         +GW+
Sbjct: 13541 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWK 13600

Query: 789   SPDSSGAD-ISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
              P S G   I  Y +++  +E   + +      ++  +DL    +Y  R+ A N+ G G 
Sbjct: 13601 KPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGT 13660

Query: 848   YSEL-VLCQTPASAPD----PVSTLCVLEEE--------PLDAYPDSPSACLVLNWEEPC 894
              SE+ V+ +    APD     +  LC L +E        P+   P +PS    ++W++  
Sbjct: 13661 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP-APS----VSWKK-- 13713

Query: 895   NNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
               G + LA    +   S  V NTT+ ++ D       +  I   N  G    +  IK   
Sbjct: 13714 --GEDPLATDTRVSVESSAV-NTTL-IVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVG 13769

Query: 955   RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED--RNKRFISIYRGPS 1012
             +P  P  P ++      +++ LKW         +E   Y L+  D   NK          
Sbjct: 13770 KPGIPTGP-IKFDEVTAEAMTLKWAPPKD-DGGSEITNYILEKRDSVNNKWVTCASAVQK 13827

Query: 1013  HTYKVQRLTEFTCYSFRIQAASE--AGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC 1070
              T++V RL E   Y+FR+ A ++   GEG  SE         VP     P +  +  +S 
Sbjct: 13828 TTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSV 13887

Query: 1071  EILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              + W       G P+  Y L+        +K+  K       F+++GL    +Y FRV A
Sbjct: 13888 SLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMA 13947



 Score =  142 bits (358), Expect = 2e-33
 Identities = 226/946 (23%), Positives = 363/946 (38%), Gaps = 128/946 (13%)

Query: 260   SDLQEYELEVKRVQDILSG------IEKPQV-------SNIQARAVVLSWAPPVGLSCGP 306
             SD  +Y + +K V     G      + KP +         + A A+ L WAPP       
Sbjct: 13743 SDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPP------K 13796

Query: 307   HSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYA--MYNSVKG 364
               G S   +Y +   D   +       + ++    +  L    +Y  RV A   Y   +G
Sbjct: 13797 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEG 13856

Query: 365   SCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNS 423
               SEP+        P+ P PP +      S++L W  P   G S IT Y LE+ E  RNS
Sbjct: 13857 LKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE--RNS 13914

Query: 424   GFRQCFFGS---QKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
                +    +    +  K+T L   + Y FR+ A N  G    S         +    P  
Sbjct: 13915 LLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK 13974

Query: 481   PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTG-EDLTCTVKNLK 539
             P ++      VTL W++P+     ++  Y +E ++  + +     +    +   TV +L 
Sbjct: 13975 PEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLV 14034

Query: 540   RSTQYKFRLTASNTEGK-SCPSE---VLVCTTSPDRPGPPTRPLVKGPVTS--------H 587
                +Y+FR+ A NT G  S PSE    ++C    + P     P +K  +T         +
Sbjct: 14035 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLN 14094

Query: 588   GFSVKWDP-PKDN---GGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP-G 640
               S+   P PK +    G +I    +        ++   + Y+    A EYT T   P G
Sbjct: 14095 AISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14154

Query: 641   TLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESG 700
             T                  E + V  L + PG   P  +      K   L W  P  + G
Sbjct: 14155 TKV----------------EHVKVTVLDV-PGPPGPVEISNVSAEKAT-LTWTPPLEDGG 14196

Query: 701   CEVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGP--YSD 756
               +  Y +E  E   +   V       C      L+ G  Y FRV A+N  G G    S+
Sbjct: 14197 SPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSE 14256

Query: 757   VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIY 815
               ++    GPPG  + P +S        V W+ P D  G++I+ Y +E  E ++SL  + 
Sbjct: 14257 PVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE-KKSLRWVR 14315

Query: 816   H----GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLC 868
                   +D R ++  L   + Y  R+ A N+AG GP SE    VL +  A  P P S   
Sbjct: 14316 AIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPH 14375

Query: 869   VLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID---------LGDTSITVGNTT 918
             V          D+      L W +P  + G EI  Y ++         + DT+ T    T
Sbjct: 14376 VT---------DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14426

Query: 919   MHVMKDLLPETTYRIRIQAINEIGAG-----PFSQFIKAKTRPLPPLPPRLECAAAGPQS 973
               V+ DL  +  Y  RI AIN+ G G     P  + ++ +      + P  E  A   ++
Sbjct: 14427 QFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVERE------MAPDFELDAELRRT 14480

Query: 974   LKLKWGDS-----NSKTHAAEDIVYT---LQLEDRNKRFISIYRGPSHTYK-VQRLTEFT 1024
             L ++ G S       K   A ++ +T   + L++R     +I    S T   +     + 
Sbjct: 14481 LVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNR----ANIENTESFTLLIIPECNRYD 14536

Query: 1025  CYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP 1084
                F +   + AG+      +        P  +   R T +  +S  + W+ +P + G  
Sbjct: 14537 TGKFVMTIENPAGK---KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWD-LPLIDGGS 14592

Query: 1085  --VNYILQVLVGRESEYK-QVYKGEEATFQISGLQTNTDYRFRVCA 1127
                NYI++        Y     K  + T++++GL    +Y FRV A
Sbjct: 14593 RITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMA 14638



 Score =  142 bits (358), Expect = 2e-33
 Identities = 222/931 (23%), Positives = 360/931 (38%), Gaps = 93/931 (9%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S      +  ++  +V LSW PP+        G +   +Y V   +  R     
Sbjct: 18889 RVLDSPSAPVNLTIREVKKDSVTLSWEPPL------IDGGAKITNYIVEKRETTRKAYAT 18942

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPP-- 385
             I  +  +    +++L+    Y+ RV A       +    +EPV  +      E P PP  
Sbjct: 18943 ITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVS------EPPLPPGR 18996

Query: 386   -KLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
               L   ++++ T++W+ P  D GSKIT Y++E  + K +  +  C         ++ L  
Sbjct: 18997 VTLVDVTRNTATIKWEKPESDGGSKITGYVVEM-QTKGSEKWSTCTQVKTLEATISGLTA 19055

Query: 444   AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA--PRLVRAGITWVTLQWSKPEGC 501
                Y FR+AA N+ G S   Q  V     +I   PS   P           L+   P   
Sbjct: 19056 GEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKG 19115

Query: 502   SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPS 560
              P+  + +  + Q  +     +   +    + ++K   +     + L  SN+ G  + P 
Sbjct: 19116 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 19175

Query: 561   EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQ 620
              ++V     DRPGPP  P+    V+    ++ W+PP+ +GG +I  Y++E  +  S    
Sbjct: 19176 TIIVL----DRPGPPG-PIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTS--TT 19228

Query: 621   WEVAYSGSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
             W +     A T      L  G+ Y+ R C  +  G S  SES  V    +A     PP  
Sbjct: 19229 WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV----VAEYPFSPPGP 19284

Query: 680   LGRPK-----HKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTV 730
              G PK        + + W VP ++ G  V  Y +E  E   +    A+++    + +  V
Sbjct: 19285 PGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIA-DTQMKV 19343

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGW 787
               L  G +Y +RV A N  G G  S   E   A     PPGQ   P ++      V + W
Sbjct: 19344 SGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQ---PEVTNITRKSVSLKW 19400

Query: 788   ESPD-SSGADISEYRLEWGE--DEESLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQA 843
               P    GA I+ Y +E  E  D   L+  Y    +T FE+ +L    +Y  R+ A N A
Sbjct: 19401 SKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAA 19460

Query: 844   GAGPYSELVLCQTPASAPDPV------------STLCVLEEEPLDAYPDSPSACL-VLNW 890
              +   SE      P    D V              + V   E L    D     L V++W
Sbjct: 19461 DS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19518

Query: 891   EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
                  +G EI           I+  N T+  +KD +   T +  +   N  G    +   
Sbjct: 19519 ---AKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNC 19572

Query: 951   KAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
             K   +P PP  P LE      +   L WG       A  D  Y ++  + +    +I  G
Sbjct: 19573 KVLDKPGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADID-YYIVEKRETSHLAWTICEG 19630

Query: 1011  PSH--TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK--SVPPTIKAPRVTQLE 1066
                  + KV +L +   Y FR+   ++ G G   E+         +VP    +  +T + 
Sbjct: 19631 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19690

Query: 1067  GNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKGEEATFQI--SGLQTNTDYRF 1123
               S  + W    S  G  ++ YI++        + +V K      ++  +GL+   +Y +
Sbjct: 19691 KESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEY 19750

Query: 1124  RVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             RV A        +  +G   PS    L R+E
Sbjct: 19751 RVYA--------ENAAGLSLPSETSPLIRAE 19773



 Score =  141 bits (355), Expect = 4e-33
 Identities = 217/905 (23%), Positives = 352/905 (38%), Gaps = 95/905 (10%)

Query: 292   VVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
             +V+SW PP+        G S   +Y +   + G+D    +  +  +  C +  L    DY
Sbjct: 10624 MVISWKPPLD------DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDY 10677

Query: 352   HVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKI 409
               R++A  +Y       S+ +        P+ P  P +   +K S  + W  P D G  I
Sbjct: 10678 IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPI 10737

Query: 410   TNYLLEWDE--GKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG---TSGYSQ 464
             TNY+LE  E   KR +   +         ++  L     Y FR++A N+IG    S  S+
Sbjct: 10738 TNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSK 10797

Query: 465   EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
              V        P  P  P  +      V L W  P      +++ Y +E Q+  ++     
Sbjct: 10798 PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRA 10857

Query: 525   KYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP------ 575
              +T E    T   V  L+    YKFR+ A N  G+S P+ V       DR  PP      
Sbjct: 10858 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDA 10917

Query: 576   ----TRPLVKGPVTSHGFSVKWDP-PKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
                  + +  G        +K  P PK       + +  E  D  ++A + +V   GS  
Sbjct: 10918 NMAREQHIKVGDTLRLSAIIKGVPFPK-------VTWKKEDRDAPTKA-RIDVTPVGSKL 10969

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI-APGQCRPPRVL--GRPKHKE 687
             E      + G +Y L      T  +   S+++ V+ L +  PG   PPR L     +   
Sbjct: 10970 EIRNAAHEDGGIYSL------TVENPAGSKTVSVKVLVLDKPG---PPRDLEVSEIRKDS 11020

Query: 688   VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH-----GPELECTVGNLLPGTVYRFR 742
              +L W  P  + G  ++ Y VE     DVAS  +        +      +L  G  Y FR
Sbjct: 11021 CYLTWKEPLDDGGSVITNYVVER---RDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFR 11077

Query: 743   VRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             V A N  G GP+ +  +   A     PPG  K           V + W  PD   G+ I+
Sbjct: 11078 VAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT 11137

Query: 799   EYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAG-PYSEL-VLC 854
              Y +E+ ++E + + I   T T  E  +  L     Y  R++A N  G G P + + + C
Sbjct: 11138 GYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIEC 11196

Query: 855   QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP----CNNGSEILA---YTIDL 907
             Q     P     + ++E   + A        ++     P      +GSEI     YT++ 
Sbjct: 11197 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVET 11256

Query: 908   GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECA 967
              + S      ++  +K+ L   T   +I   N  G+   +  +     P PP  P +   
Sbjct: 11257 DNFS------SVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP-INIL 11309

Query: 968   AAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLED-RNKRFISIYRGPSHT-YKVQRLTEFT 1024
                P+ + + W     K      ++ Y ++ +D R   +  +  G S T  K+  L +  
Sbjct: 11310 DVTPEHMTISW--QPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGC 11367

Query: 1025  CYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKG 1082
              Y FR++A ++ G G P   T T +  K  PP+    P VT +  N+  + W    S  G
Sbjct: 11368 EYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGG 11427

Query: 1083  DPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
              P+            ++ +V K    +  F+++GL     Y FRV A        + L+G
Sbjct: 11428 SPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFA--------ENLAG 11479

Query: 1141  AFSPS 1145
                PS
Sbjct: 11480 LSKPS 11484



 Score =  140 bits (353), Expect = 7e-33
 Identities = 167/655 (25%), Positives = 264/655 (40%), Gaps = 55/655 (8%)

Query: 281  KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
            KP V ++   +V L+W  P       H G +   SY + +   G D   ++       + 
Sbjct: 7684 KPTVKDVGKTSVRLNWTKP------EHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQH 7737

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTL 397
             L  L    +Y  RV A+  + +   SEP            P PP+   + + +K++  L
Sbjct: 7738 LLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADL 7797

Query: 398  QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
            +W  P  D GS ITNY++E  + +R              C +T L     Y FR+AA N 
Sbjct: 7798 KWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENA 7857

Query: 457  IGTSGYSQ---EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
            IG S Y++    V+       P  P A  +V      V L+W  P+      +  Y +E 
Sbjct: 7858 IGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEK 7917

Query: 514  QEDENDNLFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
            +E          K  G D    V ++   T+ +F++ A N  G   PSE     +  D  
Sbjct: 7918 KERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPT 7977

Query: 573  GPPTRPLVKGPVTSHG---FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             PP+ PL    VT  G    ++ W PP+ NGGS I+ Y +E+    +E  +W    S   
Sbjct: 7978 SPPSPPLDLH-VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTE--KWMRVNSRPI 8034

Query: 630  TEYTF---THLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK 686
             +  F     + P   Y LR   ++  G S+ SE +    ++  P  C+P   +    H 
Sbjct: 8035 KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSE-ISENVVAKDP-DCKP--TIDLETHD 8090

Query: 687  EVHLEWD---VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR--- 740
             + +E +   +P       V   S      E  AS+         +    +P +V     
Sbjct: 8091 IIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAG 8150

Query: 741  -FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             + +   N  G    S   ++    GP    KA  I  T   C L  WE P+   G  I 
Sbjct: 8151 IYTITLENKLGSATASINVKVIGLPGPCKDIKASDI--TKSSCKLT-WEPPEFDGGTPIL 8207

Query: 799  EYRLEWGEDEESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             Y LE  E      +     + +  + ++DL+P  +Y  R++A N+ G G Y EL   V+
Sbjct: 8208 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8267

Query: 854  CQTPASAPDPVSTLCVLEEEPLDAYPDSPSA-CLVLNWEEPC-NNGSEILAYTID 906
             Q P   PDP          P+D    +P+A  + + W+ P  + GS+I+ Y I+
Sbjct: 8268 AQDPKQPPDP----------PVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIE 8312



 Score =  140 bits (352), Expect = 9e-33
 Identities = 225/902 (24%), Positives = 350/902 (38%), Gaps = 115/902 (12%)

Query: 257  SNDSDLQEYELEVKRVQDILSG------IEKPQV------SNIQARAVVLSWAPPVGLSC 304
            S  SD   Y L+++     +SG      I +P         +I   +V L+W PP     
Sbjct: 7152 SERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGG 7211

Query: 305  GPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKG 364
             P +G      Y V   +  R    K++    +LE  + DL    +Y  +V A      G
Sbjct: 7212 SPLTG------YVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPG 7265

Query: 365  S---CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGK 420
                  EPV+ +T +  P+ P   K   R+ +S+ L W  P  D GS+I  Y++E     
Sbjct: 7266 EPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVE----- 7320

Query: 421  RNSGFRQCFFGSQK-----------HCKLTKLCPAMGYTFRLAARNDIGTSGYS---QEV 466
                  +C  GS K             ++T L     Y +R+ A N  G S  S   +E+
Sbjct: 7321 ------RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEI 7374

Query: 467  VCYTLGNIPQMPSAPRLVRAGIT---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFH 523
                    P++    +L+ AG+T      ++        PE  IT+T      + D    
Sbjct: 7375 QAVDTQEAPEIFLDVKLL-AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRIT 7433

Query: 524  PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
             +   +  T T+ + KRS    + + A N  G++     +V     D+PGPP    +   
Sbjct: 7434 IENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRAT---AVVEVNVLDKPGPPAAFDITD- 7489

Query: 584  VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTL 642
            VT+    + W+PP+D+GGS+I  Y++E    +SE   W +++ +   T +  T L P   
Sbjct: 7490 VTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV--WHKLSSTVKDTNFKATKLIPNKE 7547

Query: 643  YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE--------VHLEWDV 694
            Y  R    +  G  +  ++ P+     A  Q  PP   G P   E        V L W  
Sbjct: 7548 YIFRVAAENMYGVGEPVQASPI----TAKYQFDPP---GPPTRLEPSDITKDAVTLTWCE 7600

Query: 695  PASESGCEVSEYSVEMTEPE-DVASEVYHGPELECT--VGNLLPGTVYRFRVRALNDGGY 751
            P  + G  ++ Y VE  +P+ D        P  + T  V  L     YRFRV A N  G 
Sbjct: 7601 PDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGP 7660

Query: 752  GPYSDVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE- 806
            G  S  +E   I     PP     P +       V + W  P+   GA I  Y +E  + 
Sbjct: 7661 GKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKT 7720

Query: 807  -DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE---LVLCQTPASAPD 862
              +E + +      T+  +  L+   +Y  R++A N+AG    SE    VLC+     P 
Sbjct: 7721 GTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPS 7780

Query: 863  PVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTIDLGDTSITVGNTTMHV 921
            P   L V+      A          L W  P  + GS I  Y ++  D       T    
Sbjct: 7781 PPRWLEVINITKNTA---------DLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 7831

Query: 922  MKD-------LLPETTYRIRIQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAG 970
            +KD       L   + Y  R+ A N IG   +++    + AK     P PP  L      
Sbjct: 7832 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVT 7891

Query: 971  PQSLKLKWGDSNSKTHAAEDIV-YTLQLEDR-NKRFISIYR--GPSHTYKVQRLTEFTCY 1026
             + + LKW     K      I  Y ++ ++R   R++   +  GP   ++V  + E T  
Sbjct: 7892 KRHVDLKW--EPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 7949

Query: 1027 SFRIQAASEAGEGPFS---ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             F+++A +EAG G  S   E  +     S P       VT        I W+      G 
Sbjct: 7950 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 8009

Query: 1084 PV 1085
            P+
Sbjct: 8010 PI 8011



 Score =  140 bits (352), Expect = 9e-33
 Identities = 224/898 (24%), Positives = 357/898 (39%), Gaps = 91/898 (10%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             + +I    V L+W  P       H G S    Y +    KG D ++  I + + LEC ++
Sbjct: 14668 IMDITKSTVSLAWPKP------KHDGGSKITGYVIEAQRKGSD-QWTHITTVKGLECVVR 14720

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSE--PVSFTTHSCAPECPFP---PKLAHRSKSSLTLQ 398
             +L    +Y  +V A+ ++ + +  E  PV     +  PE        KL   +K+   ++
Sbjct: 14721 NLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVI-AKAGDNIK 14779

Query: 399   WKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAAR 454
              + P+    K T   + W +G    K+          +     + +   +    + L AR
Sbjct: 14780 VEIPVLGRPKPT---VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTAR 14836

Query: 455   NDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             N +G  G   +V+   + +IP  P+ P +       +VT  W  PE      +  Y +E+
Sbjct: 14837 NIVGEVG---DVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 14893

Query: 514   QEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLVCTTSPDR 571
             ++ ++        T    T     L    +Y+FR+ A N  G      S  +V       
Sbjct: 14894 RQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKV 14953

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP  P V   VT    ++ W  P  +GGS IL Y +E  + N    Q           
Sbjct: 14954 PGPPGTPQVTA-VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 15012

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIA--PGQCRPPRVLGRPKHKEV 688
             +  + L  G  Y+ R    +  G S+ S+ S P+  L     PG+   P  L   +H  V
Sbjct: 15013 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK---PVPLNITRHT-V 15068

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRA 745
              L+W  P    G +++ Y VE  +  +   + +   +  E E TV  L     Y FRV A
Sbjct: 15069 TLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIA 15128

Query: 746   LNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY---R 801
              N  G   P S+ S+  T        K        D  +L   E+     AD+S      
Sbjct: 15129 KNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLE-ADVSGRPPPT 15187

Query: 802   LEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP 861
             +EW +D + LE    GT  + EI+     A +   L   +       +  +    P    
Sbjct: 15188 MEWSKDGKELE----GT-AKLEIK----IADFSTNLVNKDSTRRDSGAYTLTATNPGGFA 15238

Query: 862   DPVSTLCVLE-----EEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTS---- 911
               +  + VL+     E PL     +   C VL+W  P ++G ++I  Y +   +TS    
Sbjct: 15239 KHIFNVKVLDRPGPPEGPLAVTEVTSEKC-VLSWFPPLDDGGAKIDHYIVQKRETSRLAW 15297

Query: 912   ----ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPPLPPRL- 964
                   V  T + V K LL    Y  R+ A+N+ G G    S+ + A     PP PP+  
Sbjct: 15298 TNVASEVQVTKLKVTK-LLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNP 15356

Query: 965   ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKRFISIYRGPSHTYK 1016
             E       S+ + WG  +S    +E I Y ++  D+        NK+ ++  R     YK
Sbjct: 15357 EVTTITKDSMVVCWGHPDSDG-GSEIINYIVERRDKAGQRWIKCNKKTLTDLR-----YK 15410

Query: 1017  VQRLTEFTCYSFRIQAASEAG---EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEIL 1073
             V  LTE   Y FRI A + AG     P S  Y    T   P     PRV     +S  I 
Sbjct: 15411 VSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIA 15470

Query: 1074  WETVPSMKGDPV-NYILQVLVGRESEYKQVY--KGEEAT-FQISGLQTNTDYRFRVCA 1127
             W       G  +  Y++++ +  E E++ V    G +AT + I+GL  N +Y+ R+ A
Sbjct: 15471 WNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15528



 Score =  139 bits (351), Expect = 1e-32
 Identities = 213/920 (23%), Positives = 344/920 (37%), Gaps = 85/920 (9%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE 317
             N    +EY + VK V D         V  I   +  ++W PP+        G S   +Y 
Sbjct: 13465 NSCGKKEYTIVVK-VLDTPGPPVNVTVKEISKDSAYVTWEPPI------IDGGSPIINYV 13517

Query: 318   VALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC 377
             V   D  R     +     +    + +L     Y  RV+A      G   E       S 
Sbjct: 13518 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13577

Query: 378   APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQK 434
              P      K+   SKSS ++ WK P  D GS+I  Y++++  +E K    +++       
Sbjct: 13578 TPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK----WQRVMKSLSL 13633

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIP----QMPSAPRLVRAGITW 490
                   L     YTFR++A N+ G  G   E+      ++      +   P L       
Sbjct: 13634 QYSAKDLTEGKEYTFRVSAENENG-EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKEN 13692

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
                +   P    P   +++         D     + +  + T  V + ++S   K+ +T 
Sbjct: 13693 SNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITL 13752

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G     E  +      +PG PT P+    VT+   ++KW PPKD+GGSEI  Y+LE
Sbjct: 13753 KNVAGTK---EGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILE 13809

Query: 611   ITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTL 667
               D  S  N+W    S    T +  T L  G  Y  R    +  G  +  +S P+  R  
Sbjct: 13810 KRD--SVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHP 13867

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPEL- 726
                P    PP ++   +H  V L W  P    G  ++ Y +E  E   +  +  +   + 
Sbjct: 13868 FDVPDAPPPPNIVD-VRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIR 13926

Query: 727   --ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDG 781
               +  V  L  G  Y FRV A+N  G G  S  SE   A     PPG  K   I+ T + 
Sbjct: 13927 MRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG--KPEVINITRNS 13984

Query: 782   CVLVGWESPDSSGADISEYRLEWGE-DEESLELIYHGT--DTRFEIRDLLPAAQYCCRLQ 838
               L+  E     G  ++ Y +E  +   +S     H    +  F + DL+   +Y  R++
Sbjct: 13985 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 14044

Query: 839   AFNQAGA----GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN----W 890
             A N AGA       +E ++C+    AP       VL+    D         +VLN     
Sbjct: 14045 AKNTAGAISAPSESTETIICKDEYEAP-----TIVLDPTIKDGLTIKAGDTIVLNAISIL 14099

Query: 891   EEPCNNGSEILAYTIDLGDTSIT----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPF 946
              +P    S   A   D+  + IT       ++M  +K    +      I A N  G    
Sbjct: 14100 GKPLPKSSWSKAGK-DIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK-- 14156

Query: 947   SQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAED-----IVYTL 995
              + +K     +P  P  +E +    +   L W      G S  K++  E      +++T+
Sbjct: 14157 VEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTV 14216

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
               ED            S  +   +L +   Y FR+ A +  G+G    SE          
Sbjct: 14217 VSEDIQ----------SCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGP 14266

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATF 1110
             P   + P V+ +  N+  + W+      G  +  Y ++    +   + +  K    +   
Sbjct: 14267 PGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 14326

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             +++GLQ  + Y FRV A  R
Sbjct: 14327 KVTGLQEGSTYEFRVSAENR 14346



 Score =  136 bits (343), Expect = 1e-31
 Identities = 209/842 (24%), Positives = 320/842 (38%), Gaps = 80/842 (9%)

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWK 400
             DL     Y  RV A      G   E +  TT       P PP   K+   +K+++ L WK
Sbjct: 9669  DLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWK 9728

Query: 401   API-DNGSKITNYLLE---WDE-GKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
              P  D GS +T+Y++E   WD  G +   +RQC     +  + T   L     Y FR+ A
Sbjct: 9729  PPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9788

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR----------------AGITWVTLQWSK 497
              N  G S  S  V        P MP +  L                   G+ + TL W K
Sbjct: 9789  VNAAGVSKPSATVGPCDCQR-PDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFK 9847

Query: 498   PEGCSPE--EVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
                  P+  E + Y   + +   D+           TCT  +   +RS    + +TA N 
Sbjct: 9848  APPKKPDNKEPVLYDTHVNKLVVDD-----------TCTLVIPQSRRSDTGLYTITAVNN 9896

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITD 613
              G +     L       RPGPP  P+    V++   ++ W PPKD+GGS+I  Y++E  +
Sbjct: 9897  LGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKRE 9953

Query: 614   GNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIA 670
              N +   W  V+       YT   L  G  Y  R    +  G  +  +S P   R L   
Sbjct: 9954  ANRKT--WVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSV 10011

Query: 671   PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT 729
             PG    P V    ++  + + W+ P  + G  V+ Y +EM +        V   P    T
Sbjct: 10012 PGAPDKPTVSSVTRN-SMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMT 10070

Query: 730   VG------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP--PGQCKAPCISCTPDG 781
             +G       L+ G+ Y+FRV A+N  G GP S  S+  TA  P  P     P ++     
Sbjct: 10071 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKS 10130

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGTD-----TRFEIRDLLPAAQYCC 835
                + W  P    G+ ++ Y +E+   EE  E    G D     T+  +  L   A Y  
Sbjct: 10131 SADLEWSPPLKDGGSKVTGYIVEY--KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKF 10188

Query: 836   RLQAFNQAGAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP 893
             R++A N AG G   E+  + +       P   L     + +  +       +  ++ + P
Sbjct: 10189 RVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPP 10248

Query: 894   CNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                   +   T+    T  T   ++  V+K+          + A NE G    +  +   
Sbjct: 10249 PTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10308

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKW-GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPS 1012
               P P   P L       +S KL W    +       + V   +  DR       Y    
Sbjct: 10309 DVPGPVGTPFLAHNLTN-ESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTR 10367

Query: 1013  HTYKVQRLTEFTCYSFRIQAASEAGEGPF---SETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                 VQ L +   Y FRI A +  G GPF   SE        +VP   +   V ++  N+
Sbjct: 10368 QNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNT 10427

Query: 1070  CEILWETVPSMKG--DPVNYILQV-LVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRV 1125
               + W   P   G  + +NY+L+  L+G E  +K          + + GL+    Y +RV
Sbjct: 10428 VTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10486

Query: 1126  CA 1127
              A
Sbjct: 10487 SA 10488



 Score =  136 bits (343), Expect = 1e-31
 Identities = 208/839 (24%), Positives = 321/839 (38%), Gaps = 83/839 (9%)

Query: 342   LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQ 398
             + DL     Y+ RV A+     G   EP        A E P PP+   +   SKSS  L 
Sbjct: 22204 VNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLA 22260

Query: 399   WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
             W  P  D GS+IT YLLE  + K +  + +     Q    + +L     Y FR+ A+ND 
Sbjct: 22261 WLKPDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND- 22318

Query: 458   GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCS------PEEVITY 509
               +GYS+    ++   I +    P     GIT   +T +   P          P   +T+
Sbjct: 22319 --AGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTW 22376

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
              LE    +  +      T +  T TVK+  R    ++ LT  NT G    S  +V     
Sbjct: 22377 KLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI--- 22433

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-S 628
              RPGP T P+    V++    + W  PKD GG+EI  Y++E  +  + A  W++  S   
Sbjct: 22434 GRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTA--WQLVNSSVK 22491

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
              T+   THL     Y  R    +  G S+  ES P+    IA     PP    RP+   V
Sbjct: 22492 RTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPI----IAEHPFVPPSAPTRPEVYHV 22547

Query: 689   -----HLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT--VGNLLPGTVYR 740
                   + W+ P  + G ++  Y VE  E   +   +    P LEC   V  L+ G  Y+
Sbjct: 22548 SANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQ 22607

Query: 741   FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISE 799
             FR  ALN  G    S+ S    A  P      P ++      V + W +P    G+ +  
Sbjct: 22608 FRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVG 22667

Query: 800   YRLEWGE-----DEESLELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAG--------A 845
             Y +E        D   L+  Y   +D  F +  L     Y  R+ A N AG         
Sbjct: 22668 YIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST 22727

Query: 846   GPYSELVLCQTPASAP---------DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN 896
             GP    V C+   + P           + T+    +  LDA         ++ W +   +
Sbjct: 22728 GP----VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKII-WTK--GD 22780

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
                 L   + L  T    G     V+K      + +  +   N  G    S  +K    P
Sbjct: 22781 KELDLCEKVSLQYT----GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 22836

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG--PSHT 1014
              P    +L  +    +   L W     +   AE   Y ++  + ++    I  G  P+ +
Sbjct: 22837 GP--CGKLTVSRVTQEKCTLAW-SLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLS 22893

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEG--PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             Y V RL +   Y FR++A ++ G G    SE      + ++P     P           I
Sbjct: 22894 YVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIII 22953

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQV---YKGEEATFQISGLQTNTDYRFRVCA 1127
              W    S  G+ + NY++     +   + +V   Y   +   +++ L    DY+FRV A
Sbjct: 22954 QWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTA 23012



 Score =  136 bits (342), Expect = 1e-31
 Identities = 223/927 (24%), Positives = 346/927 (37%), Gaps = 101/927 (10%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKP-QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSY 316
             N S   + E++VK VQD    +  P + +NI    + L W  P+   C P +       Y
Sbjct: 21730 NASGSAKAEIKVK-VQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT------HY 21782

Query: 317   EVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTT 374
              +   +  R     I    E        L    +Y  RV A+     G    S+PV    
Sbjct: 21783 IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQI 21842

Query: 375   HSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-- 431
                 P+ P  P+ ++ + +S+TL W  P  D GS+I  Y+LE  E K     +       
Sbjct: 21843 QYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPI 21902

Query: 432   SQKHCKLTKLCPAMGYTFRLAARNDIGT---SGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
             S+   K+T L     Y F + A N  G    SG S+ + C    N P  P+  ++     
Sbjct: 21903 SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSK 21962

Query: 489   TWVTLQWSKPEGCSPEEVITYTLEI-QEDENDNLFHPKYTGE---DLTCTVKNLKRSTQY 544
             T V+L+WSKP      E+I Y +E+ + D  D  +H K   E       TV +L+   +Y
Sbjct: 21963 TTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD--WH-KVNAEACVKTRYTVTDLQAGEEY 22019

Query: 545   KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVK-------- 592
             KFR++A N  GK    EV     + DR   P   +      +H    G S++        
Sbjct: 22020 KFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGR 22079

Query: 593   ------WDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
                   W  P  N     L+  +  TD  S     E      A +YT T           
Sbjct: 22080 PTPTAVWSKPDSNLS---LRADIHTTDSFSTLTV-ENCNRNDAGKYTLT----------- 22124

Query: 647   ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEY 706
                 +  G    + ++ V      PG    P            L WD P  + G  +  Y
Sbjct: 22125 --VENNSGSKSITFTVKVLDTPGPPG----PITFKDVTRGSATLMWDAPLLDGGARIHHY 22178

Query: 707   SVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGPYSDVSEIT 761
              VE  E    + +V      +CT     V +L  G  Y FRV A+N+ G G   ++ E  
Sbjct: 22179 VVEKREASRRSWQVI---SEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPI 22235

Query: 762   TAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL-IYHGTD 819
              A   P   +   +  T     ++ W  PD   G+ I+ Y LE  +      +   H   
Sbjct: 22236 VATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ 22295

Query: 820   TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE------LVLCQTPASAPDPVSTLCVLEEE 873
               F +  L+   +Y  R++A N AG   YSE       V+ + P    +P + L  +  +
Sbjct: 22296 LTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEPQI--EPTADLTGITNQ 22350

Query: 874   PLDAYPDSPSACLVLNWEEPCNNGS----EILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
              +     SP    V     P    +    E+     D    + T   TT+ V KD +   
Sbjct: 22351 LITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV-KDSMRGD 22409

Query: 930   TYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
             + R  +   N  G   FS  +    RP P   P +E ++   +S  L WG+         
Sbjct: 22410 SGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGEPKDGGGTEI 22468

Query: 990   DIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTF 1047
                   + E     +  +      T  KV  LT++  YSFR+ + +  G   P       
Sbjct: 22469 TNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPII 22528

Query: 1048  STTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGE 1106
             +    VPP+    P V  +  N+  I WE       D  + I+   V ++     ++  E
Sbjct: 22529 AEHPFVPPSAPTRPEVYHVSANAMSIRWE---EPYHDGGSKIIGYWVEKKERNTILWVKE 22585

Query: 1107  ------EATFQISGLQTNTDYRFRVCA 1127
                   E  ++++GL    +Y+FR  A
Sbjct: 22586 NKVPCLECNYKVTGLVEGLEYQFRTYA 22612



 Score =  135 bits (341), Expect = 2e-31
 Identities = 234/959 (24%), Positives = 370/959 (38%), Gaps = 149/959 (15%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             +KP VS++   ++ ++W  P      P +G         +   K R  +  I      + 
Sbjct: 10016 DKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK-RVNRDPIKAMTLGVS 10074

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT--HSCAPECPFPPKLAHRSKSSLTL 397
               +  L   +DY  RVYA+  +  G  S P    T     AP  P  PK+   +KSS  L
Sbjct: 10075 YKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADL 10134

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLC-----PAMGYTFRL 451
             +W  P+ D GSK+T Y++E+ E     G  +   G  K  + TKL          Y FR+
Sbjct: 10135 EWSPPLKDGGSKVTGYIVEYKE----EGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRV 10190

Query: 452   AARN--DIGTSGYSQEVVCYTLGNIP---QMPSAPR---LVRAG-----ITWV------T 492
              A N   IG  G   +V+      +    Q+ ++ R   +V AG     I +V      T
Sbjct: 10191 RAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPT 10250

Query: 493   LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN 552
             + W+  E   P+E    T  I                  +  +KN +RS Q  + L A N
Sbjct: 10251 VTWNMNERTLPQEATIETTAISS----------------SMVIKNCQRSHQGVYSLLAKN 10294

Query: 553   TEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT 612
               G+    +  +     D PGP   P +   +T+    + W  P+D+GGS I  Y++E  
Sbjct: 10295 EAGER---KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKR 10351

Query: 613   DGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLS 668
             +  S+   W  V Y+ +    T   L  G  Y  R      I  G   + SE+L +R   
Sbjct: 10352 E--SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPI 10409

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP---- 724
               P +     V    K+  V L W+ P  + G E+  Y   + E   + +E +H      
Sbjct: 10410 TVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINY---VLESRLIGTEKFHKVTNDN 10465

Query: 725   --ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT---- 778
                 + TV  L  G  Y +RV A+N  G G  S  ++       P  CK      T    
Sbjct: 10466 LLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTK-------PITCKDELAPPTLHLD 10518

Query: 779   -PDGCVLVGWESPDSSG--ADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCC 835
               D   +   E+   +G  +   + ++ W +DE  +       D R  I+   PA     
Sbjct: 10519 FRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVL-----EDDRTHIK-TTPATLALE 10572

Query: 836   RLQAFNQAGAGPYSELV---------LCQT-----PASAPDPVSTLCVLEEEPLDAYPDS 881
             +++A  ++ +G Y  +V          CQ      P     PVS            + + 
Sbjct: 10573 KIKA-KRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVS------------FDEV 10619

Query: 882   PSACLVLNWEEPCNN-GSEILAYTIDLGDTSITV--------GNTTMHVMKDLLPETTYR 932
                 +V++W+ P ++ GS+I  Y I+  +    V          TT  V K LL    Y 
Sbjct: 10620 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSK-LLEGKDYI 10678

Query: 933   IRIQAINEIGAGP--FSQFIKAKTR-PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
              RI A N  G      S  +KAK R  +P  P +         S  + W    +K H   
Sbjct: 10679 FRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTW----NKPHDGG 10734

Query: 990   DIVYTLQLEDR---NKRFISIYRGPSHTY---KVQRLTEFTCYSFRIQAASEAGEG---P 1040
               +    LE R   +KR+  + + P H Y   +V  L E   Y FR+ A +E G G   P
Sbjct: 10735 KPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSP 10794

Query: 1041  FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              S+        + P     P       NS ++ W+      G  +  YI++     + E+
Sbjct: 10795 PSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEW 10854

Query: 1100  KQVYKGEEA----TFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             ++     E+     ++++GL+    Y+FRV A    ++ + E   A  P    V  R E
Sbjct: 10855 RRANHTPESCPETKYKVTGLRDGQTYKFRVLA----VNAAGESDPAHVPEPVLVKDRLE 10909



 Score =  135 bits (340), Expect = 2e-31
 Identities = 228/931 (24%), Positives = 358/931 (38%), Gaps = 118/931 (12%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
             K  V ++   +V LSW  P       H G S    Y V +  K  + K+      + L+ 
Sbjct: 16831 KITVDDVTRNSVSLSWTKP------EHDGGSKIIQYIVEMQAKHSE-KWSECARVKSLQA 16883

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL-----AHRSKSSL 395
              + +L    +Y  RV A+  + KG  S+P S      A +    P +     ++  +   
Sbjct: 16884 VITNLTQGEEYLFRVVAV--NEKGR-SDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQ 16940

Query: 396   TLQWKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              L+ + PI    K T   + W +     K+ +              + +     G  + +
Sbjct: 16941 DLKIEVPISGRPKPT---ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16997

Query: 452   AARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYT 510
                N +G    S E+V  TL   P  P  P +        +TL W+ P      ++  Y 
Sbjct: 16998 TVANVVGQKTASIEIV--TLDK-PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYI 17054

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS--CPSEVLVCTTS 568
             ++ ++           T    T  V  LK  T+Y+FR+ A N  G+S    S+ +V    
Sbjct: 17055 VQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 17114

Query: 569   PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS----EANQWEVA 624
                PGPP  P     ++     ++W  P +NGGS ++ Y LE  + NS    + N+  + 
Sbjct: 17115 YKEPGPPGTPFATA-ISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII- 17172

Query: 625   YSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
                  T++   +L+ G  Y+ R      +  G  S+ SE    R     PG   P  V  
Sbjct: 17173 ---HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMV-- 17227

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTV 738
               K  E+ L+W  P  + G  ++ Y VE  +  D   + +   +  E + TV  L     
Sbjct: 17228 --KRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQR 17285

Query: 739   YRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWES----PD 791
             Y FRV A N  G    S  S+ T       + + P IS  P   D  V+   E+     D
Sbjct: 17286 YEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEAD 17343

Query: 792   SSGADISEYRLEW----GEDEESLELIYHGTDTR--FEIRDLL--PAAQYCCRLQAFNQA 843
               G  +    +EW     E EES       TD +    ++D +     QY   L+A N A
Sbjct: 17344 VHGKPLPT--IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI--LRASNVA 17399

Query: 844   GAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEIL 901
             G+  +   V +   P     PV    V  E+              L W  P  +G S+I 
Sbjct: 17400 GSKSFPVNVKVLDRPGPPEGPVQVTGVTSEK------------CSLTWSPPLQDGGSDIS 17447

Query: 902   AYTIDLGDTS-----ITVGNTTMHVMK--DLLPETTYRIRIQAINEIGAG-PFSQFIKAK 953
              Y ++  +TS     +       + +K   LL    Y  RI A+N+ G G P        
Sbjct: 17448 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 17507

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKR 1003
               P  LP  P  LE       S+ + W   +S    +E I Y ++  DR        NKR
Sbjct: 17508 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDG-GSEIIGYIVEKRDRSGIRWIKCNKR 17566

Query: 1004  FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSV----PPTIK 1058
              I+  R      +V  LTE   Y FR+ A + AG G P   T  +     V    PPT  
Sbjct: 17567 RITDLR-----LRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPT-- 17619

Query: 1059  APRVTQLEGNSCEILW-ETVPSMKGDPVNYILQVLVGRESEYKQV--YKGEEAT-FQISG 1114
                +     NS  + W + +     + + Y++++    E E++ V    G   T F+IS 
Sbjct: 17620 NAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK 17679

Query: 1115  LQTNTDYRFRVCACRRC-LDTSQELSGAFSP 1144
             L  + +Y+ RVCA  +  L  +  + G   P
Sbjct: 17680 LTEHQEYKIRVCALNKVGLGEATSVPGTVKP 17710



 Score =  135 bits (340), Expect = 2e-31
 Identities = 181/709 (25%), Positives = 289/709 (40%), Gaps = 74/709 (10%)

Query: 466   VVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
             +   TLG  P  P  P R        V L W  PE     E+  Y++E +E    N    
Sbjct: 21344 ITVITLGP-PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMV 21402

Query: 525   KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP--SEVLVCTTSPDRPGPPTRPLVKG 582
               +    T  V NL +  +Y+FR+ A N  G S P  S ++V       PGPP +P++  
Sbjct: 21403 CSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21462

Query: 583   PVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTL 642
              VTS G S+ WD P  +GGSE+  + +E  + NS   Q       S  EY  T L  G  
Sbjct: 21463 -VTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLD 21521

Query: 643   YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPAS 697
             Y+ R    ++ G S  S+     TL+++P    PP   G P + +V      L+W+ P  
Sbjct: 21522 YQFRVYAENSAGLSSPSDPSKF-TLAVSPVD--PP---GTPDYIDVTRETITLKWNPPLR 21575

Query: 698   ESGCEVSEYSVEMTEPED--VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
             + G ++  YS+E  +  +  V        E + TV  L PG  Y FR+ A N    G  S
Sbjct: 21576 DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARN--AVGTIS 21633

Query: 756   DVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWESPDSS----GADISEYRLEWGEDE 808
               S+ +       +   P +   P   DG ++   ES        G  +   R+ W +D 
Sbjct: 21634 PPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP--RVTWFKDG 21691

Query: 809   ESLE--LIYHGTD----TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ-TPASAP 861
               +E  +    TD    T   +RD     +    ++A N +G+      V  Q TP    
Sbjct: 21692 VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21751

Query: 862   DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVG----- 915
              P+    +  E+            + L W+ P N+G + I  Y I+  +TS         
Sbjct: 21752 GPIRFTNITGEK------------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIED 21799

Query: 916   --NTTMHVMKDLLPETTYRIRIQAINEIGAG-PF-SQFIKAKTR-PLPPLPPRLECAAAG 970
                   +    L+    Y+ R+ A+N+ G G P  S  + A+ +  +P  P   E +   
Sbjct: 21800 KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNIT 21859

Query: 971   PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY--RGPSHT-YKVQRLTEFTCYS 1027
               S+ L W    S   +        + E ++ R++ +   R  S T +KV  LTE   Y 
Sbjct: 21860 GNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYE 21919

Query: 1028  FRIQAASEAGEGPFSETYTFSTTKSV-----PPTIKAPRVTQLEGNSCEILWETVPSMKG 1082
             F + A + AG GP S        +       PPT+   +VT     +  + W + P   G
Sbjct: 21920 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTV--VKVTDTSKTTVSLEW-SKPVFDG 21976

Query: 1083  --DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCA 1127
               + + YI+++      ++ +V      +  + ++ LQ   +Y+FRV A
Sbjct: 21977 GMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 22025



 Score =  133 bits (335), Expect = 9e-31
 Identities = 209/942 (22%), Positives = 351/942 (37%), Gaps = 109/942 (11%)

Query: 243   GIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGL 302
             G++ T R +  +       L+   +  +   D+      P + +++  +V L+W  P   
Sbjct: 13838 GMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKT 13897

Query: 303   SCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362
                P +G    +    +L  K R  K  I       +  +  L    +Y  RV A+  + 
Sbjct: 13898 GGSPITGYHLEFKERNSLLWK-RANKTPI----RMRDFKVTGLTEGLEYEFRVMAINLAG 13952

Query: 363   KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKR 421
              G  S P          + P  P++ + +++S+TL W  P  D G K+T Y++E  +   
Sbjct: 13953 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPS 14012

Query: 422   NSGFR-------QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYT 470
              S  +       +C F       +T L     Y FR+ A+N  G     S  ++ ++C  
Sbjct: 14013 KSWMKANHVNVPECAF------TVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKD 14066

Query: 471   LGNIPQMPSAPRL-----VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPK 525
                 P +   P +     ++AG T V    S      P+   +++   ++    ++    
Sbjct: 14067 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKS--SWSKAGKDIRPSDITQIT 14124

Query: 526   YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
              T      T+K   R    ++ +TA+N  G        V  T  D PGPP  P+    V+
Sbjct: 14125 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH---VKVTVLDVPGPPG-PVEISNVS 14180

Query: 586   SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYK 644
             +   ++ W PP ++GGS I  Y+LE  +  +    W V      +  +  T L  G  Y 
Sbjct: 14181 AEKATLTWTPPLEDGGSPIKSYILEKRE--TSRLLWTVVSEDIQSCRHVATKLIQGNEYI 14238

Query: 645   LRACCISTGGHSQCSESLPVRTLSI--APGQCRPPRVLGRPKHKEVHLEWDVPASESGCE 702
              R   ++  G  +  +S PV+ +     PG    P V    K+    + W  P  + G E
Sbjct: 14239 FRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTAT-VSWKRPVDDGGSE 14297

Query: 703   VSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             ++ Y VE  E +    V +      +L C V  L  G+ Y FRV A N  G GP S+ S+
Sbjct: 14298 ITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASD 14357

Query: 760   ---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLE--------WGED 807
                +  AA PPG    P ++ T      + W  P    G +I+ Y +E        W +D
Sbjct: 14358 SVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKD 14417

Query: 808   EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL 867
                  L      T+F + DL    +Y  R+ A N AG G          PA  PD    +
Sbjct: 14418 TTGTAL----RITQFVVPDLQTKEKYNFRISAINDAGVG---------EPAVIPD----V 14460

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS--ITVGNTTMHVMKDL 925
              ++E E    +         L        G  I  +    G  +  +T     +++    
Sbjct: 14461 EIVEREMAPDFELDAELRRTL----VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRA 14516

Query: 926   LPETTYRIRIQAINEIG--------------AGPFSQFIKAKTRPLPPLPPRLECAAAGP 971
               E T    +  I E                AG  S F+  +    P     L       
Sbjct: 14517 NIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITK 14576

Query: 972   QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH--TYKVQRLTEFTCYSFR 1029
              S+ L W D       +    Y ++  +  ++  S      H  TYKV  L+E   Y FR
Sbjct: 14577 DSVTLHW-DLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 14635

Query: 1030  IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYI 1088
             + A +E G G  +ET         P    +  +  +  ++  + W       G  +  Y+
Sbjct: 14636 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 14695

Query: 1089  LQ-------------VLVGRESEYKQVYKGEEATFQISGLQT 1117
             ++              + G E   + + +GEE TFQ+  + +
Sbjct: 14696 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNS 14737



 Score =  130 bits (327), Expect = 8e-30
 Identities = 183/802 (22%), Positives = 305/802 (38%), Gaps = 105/802 (13%)

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             ++   TL W  P  D G++IT+Y++E  E  R +              +T+L     Y F
Sbjct: 22848 TQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIF 22907

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
             R+ A N  G      S+ +V      IP  P  P  V  G   + +QW+KPE     E+ 
Sbjct: 22908 RVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEIS 22967

Query: 508   TYTLEIQEDENDNL--FHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV--- 562
              Y ++ +E ++      +  Y   D    V +L     Y+FR+TA N  G S PSE    
Sbjct: 22968 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNF 23027

Query: 563   LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
             + C      PGPP+ P V    T H  S+ W  P  +GG++I+ Y+LE+ +   + +QW 
Sbjct: 23028 ISCREPSYTPGPPSAPRVVD-TTKHSISLAWTKPMYDGGTDIVGYVLEMQE--KDTDQWY 23084

Query: 623   VAYSGSA---TEYTFTHLKPGTLYKLRACCISTGGHSQCSESL----PVRTLSIAPGQCR 675
               ++ +    TE+T   LK G  Y  R   ++  G S+ SES+    PV  + I      
Sbjct: 23085 RVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEI------ 23138

Query: 676   PPRVLGRPKHKEVHLEWDVP----ASESG-----CEVSEYSVEMTEPEDVASEVYHGPEL 726
             P   L     K V +          S SG        S+  +++     + +   +   +
Sbjct: 23139 PDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI 23198

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V     G   ++ + A N  G       + +      PG C +  +       V + 
Sbjct: 23199 VDKVNRYDAG---KYTIEAENQSGK---KSATVLVKVYDTPGPCPSVKVKEVSRDSVTIT 23252

Query: 787   WESPD-SSGADISEYRLEWGEDEESLELIYHGTD----TRFEIRDLLPAAQYCCRLQAFN 841
             WE P    GA ++ Y +E  + E ++      T     T + I  L+    Y  R+   N
Sbjct: 23253 WEIPTIDGGAPVNNYIVE--KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPEN 23310

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEI 900
               G G   E       +  P   + L V+         D   + + L WE+P  + GS +
Sbjct: 23311 IYGIGEPCETSDAVLVSEVPLVPAKLEVV---------DVTKSTVTLAWEKPLYDGGSRL 23361

Query: 901   LAYTIDLGDTS-------ITVGNTTM-HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA 952
               Y ++            +T+  T + H +  L     Y  RI+A NE G     + + A
Sbjct: 23362 TGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTA 23421

Query: 953   KT----RPLPPL----------------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV 992
              T    R LP +                P  L    AG       W  + SK   +E + 
Sbjct: 23422 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 23481

Query: 993   YTL--QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
                  ++     R  +I     +T +++ +T  T  + ++    + G             
Sbjct: 23482 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG------------- 23528

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG-EEA 1108
                PPT    ++ +++  S  I WE      G P++ Y+++        +  V +    +
Sbjct: 23529 ---PPTGPI-KIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS 23584

Query: 1109  TFQISGLQTNTDYRFRVCACRR 1130
             TF+ + L    +Y FRV A  R
Sbjct: 23585 TFKFTRLTEGNEYVFRVAATNR 23606



 Score =  130 bits (326), Expect = 1e-29
 Identities = 226/960 (23%), Positives = 367/960 (38%), Gaps = 129/960 (13%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKG-RDGKYKIIYSGEELE 339
             KP V++I   A  +SW  P      P +G    Y     ++ K  R  K  I     +L+
Sbjct: 11404 KPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREVTGKWVRVNKTPIA----DLK 11456

Query: 340   CNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLT 396
               +  L     Y  RV+A      S     S+P+        P  P  PKL  +S+ +  
Sbjct: 11457 FRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD 11516

Query: 397   LQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGY 447
             L W  P+ D GS I  Y++E        W+   ++   RQC F      ++  L     Y
Sbjct: 11517 LVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAF------RVPGLIEGNEY 11570

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---------VRAGITWVTLQWSKP 498
              FR+ A N +G  G  +E+    +      P    L         VR G T   L   K 
Sbjct: 11571 RFRIKAANIVG-EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKG 11629

Query: 499   EGCSPEEVITYTLE----IQEDENDNLFHPKYTGEDLT---CTVKNLKRSTQYKFRLTAS 551
                 PE  IT+T E    ++E   D +       +DL      +K   R+   K+ ++A 
Sbjct: 11630 R---PEPDITWTKEGKVLVREKRVDLI-------QDLPRVELQIKEAVRADHGKYIISAK 11679

Query: 552   NTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEI 611
             N+ G +  S ++      DRPGP     V   VT    ++ W+ P DNGGSEI  +++E 
Sbjct: 11680 NSSGHAQGSAIVNVL---DRPGPCQNLKVTN-VTKENCTISWENPLDNGGSEITNFIVEY 11735

Query: 612   TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES-LPVRTLSIA 670
                N +   W +  S         +L     Y  R C  +  G     E+  P+  ++  
Sbjct: 11736 RKPNQKG--WSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPI 11793

Query: 671   PGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHG--PEL 726
                  P  +    K K  V+L+W  P  + G     Y VE   +  D    V+ G   E 
Sbjct: 11794 DRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11853

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V   +   +Y FRV+  N+GG   +    E+          + P +     G + V 
Sbjct: 11854 HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKE----DLQKPVLDLKLSGVLTVK 11909

Query: 787   WESPDSSGADISEY---RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                     A +       + W +D+++ +L       R +I     ++++   L    ++
Sbjct: 11910 AGDTIRLEAGVRGKPFPEVAWTKDKDATDLT---RSPRVKIDTRADSSKF--SLTKAKRS 11964

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEE-------EPLDAYPDSPSACLVLNWEEPCNN 896
               G Y  +V     A +    +T+ VL++       + +D   D  + C    W+ P ++
Sbjct: 11965 DGGKY--VVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVC----WDPPEDD 12018

Query: 897   GS-EILAYTIDLGDTSITVGNTTMHVMKDLLPETT---------YRIRIQAINEIGAGP- 945
             G  EI  Y ++  +T   V +T    +  L P TT         Y  R++A N+IG GP 
Sbjct: 12019 GGCEIQNYILEKCETKRMVWSTYSATV--LTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 12076

Query: 946   -FSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
               S+ + AKT   +P  P PP  E      + + + W         +    +  + E  +
Sbjct: 12077 TESKPVIAKTKYDKPGRPDPP--EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 12134

Query: 1002  KRFISIYRG--PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV-----P 1054
              R++ + +   P    KVQ L     Y FR++A +E G G  S        K       P
Sbjct: 12135 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGP 12194

Query: 1055  PTIKAPRVTQLEGNSCEILWETVPSMKGDP-VNYILQVL-----VGRESEYKQVYKGEEA 1108
             PT    RV     +S  + W       G P + Y++++         +  +K+     + 
Sbjct: 12195 PT--NFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12252

Query: 1109  T---FQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSL 1164
                 F ++ L  N +Y FRVCA  +  +    EL  A  P    +L+  E+ L   M  L
Sbjct: 12253 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASMRKL 12310



 Score =  129 bits (325), Expect = 1e-29
 Identities = 204/922 (22%), Positives = 356/922 (38%), Gaps = 76/922 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S     +V+ I   +V ++W PP+        G S   +Y V   +  R     
Sbjct: 16724 RVLDTPSPPVNLKVTEITKDSVSITWEPPL------LDGGSKIKNYIVEKREATRKSYAA 16777

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             ++ +  +    +  L+    Y+ RV A      G  ++       +  P+ P    +   
Sbjct: 16778 VVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDV 16837

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W  P  D GSKI  Y++E  + K +  + +C         +T L     Y F
Sbjct: 16838 TRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLF 16896

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVI 507
             R+ A N+ G S      V     ++   P       +    V   L+   P    P+  I
Sbjct: 16897 RVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI 16956

Query: 508   TYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             T+T +    +     +   + +  T ++K   +    ++ +T +N  G+   S  +V   
Sbjct: 16957 TWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL- 17015

Query: 568   SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG 627
               D+P PP  P+    V++   ++ W+PP   GG +I  Y+++  D  +    W+V  + 
Sbjct: 17016 --DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD--TTTTVWDVVSAT 17071

Query: 628   SA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP--- 683
              A T    T LK GT Y+ R    +  G S   ES P+    +A    + P   G P   
Sbjct: 17072 VARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI----VAQYPYKEPGPPGTPFAT 17127

Query: 684   --KHKEVHLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPG 736
                   + ++W  P +  G  V  Y +E  E        V   + H  + +    NL  G
Sbjct: 17128 AISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ--NLEEG 17185

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
               Y FRV A N  G G  S  SE   A  P      P         + + W  P    G+
Sbjct: 17186 IEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGS 17245

Query: 796   DISEYRLEWGE--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELV 852
              I+ Y +E  +  D   ++  +    +T+F +  L    +Y  R+ A N AGA       
Sbjct: 17246 MITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGA------- 17298

Query: 853   LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE----EPCNNGSEILAYTIDLG 908
                 P+ +  P++    +E   +   P      +V   E    E   +G  +       G
Sbjct: 17299 -ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 17357

Query: 909   DTSI------TVGNT---TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
             D  I       + NT    + ++KD +     +  ++A N  G+  F   +K   RP PP
Sbjct: 17358 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17417

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLEDRNKRFISIYRGP--SHTYK 1016
               P ++      +   L W  S        DI  Y ++  + ++   ++      +++ K
Sbjct: 17418 EGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLK 17474

Query: 1017  VQRLTEFTCYSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
             V +L E   Y FRI A ++ G G   E+          +P   K+  VT +  +S  + W
Sbjct: 17475 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 17534

Query: 1075  ETVPSMKG-DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCACRRC 1131
                 S  G + + YI++        + +  K    +   +++GL  + +Y FRV A    
Sbjct: 17535 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA---- 17590

Query: 1132  LDTSQELSGAFSPSAAFVLQRS 1153
                 +  +G   PS A V  ++
Sbjct: 17591 ----ENAAGVGEPSPATVYYKA 17608



 Score =  129 bits (323), Expect = 2e-29
 Identities = 206/920 (22%), Positives = 363/920 (39%), Gaps = 81/920 (8%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EELEC 340
             P+V+ I   ++ + W+ P+       SG      Y +   DK   G +K++     +   
Sbjct: 20767 PEVTKITKNSMTVVWSRPIADGGSDISG------YFLEKRDKKSLGWFKVLKETIRDTRQ 20820

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTL 397
              +  L   +DY  RV A+  + +G  SEP  F   +   + P PP   ++A  +KSS+TL
Sbjct: 20821 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITL 20880

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
              W  P+ D GS +T Y++E  +G+          G  +  +  ++ L P + Y FR++A 
Sbjct: 20881 GWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAV 20940

Query: 455   NDIGTSG---YSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVITY 509
             N  G       ++ V    +   P++     L  + I      +Q   P    P   +T+
Sbjct: 20941 NCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTW 21000

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
               + +   +D  +  + T      T+  + R+   K+ LT  N  G+  P    V     
Sbjct: 21001 RKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE--PKSSTVSVKVL 21058

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV-AYSGS 628
             D P    +  VK  V+    ++ WDPP  +GGS I+ Y++E  D       W V ++  S
Sbjct: 21059 DTPAACQKLQVKH-VSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRT--WSVVSHKCS 21115

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQ-CSESLPVRTLSIAPGQCRPPRVLGRPKHKE 687
             +T +    L   T +  R    +  G  + C  + PV+   + P   R   +    K   
Sbjct: 21116 STSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEV-PAPIRDLSMKDSTK-TS 21173

Query: 688   VHLEWDVPASESGCEVSEYSVEMT-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V L W  P  + G  ++EY VE   + E   S        E  V  L   +V  FRV A 
Sbjct: 21174 VILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAK 21233

Query: 747   NDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGE 806
             N+ G      +  IT         K   I+   D   + G +     G ++       G+
Sbjct: 21234 NEKGLSDPVTIGPITV--------KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGK 21285

Query: 807   DEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPV 864
              + S+  +  G   +    +R      +    ++   +   G Y+ ++L         P+
Sbjct: 21286 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT-VILDNAVCRIAVPI 21344

Query: 865   STLCV----LEEEPLDAYPDSPSACLVLNWEEPCNNGS-EILAYTIDLGDTSIT------ 913
             + + +      + P+  + +  +  ++L+W+ P +NG  EI  Y+I+  +TS T      
Sbjct: 21345 TVITLGPPSKPKGPI-RFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVC 21403

Query: 914   --VGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTR---PLPPLPPRLEC 966
               V  TT  V  +L+ +  Y+ R++A N  G      S  I AK +   P PP  P +  
Sbjct: 21404 SSVARTTFKV-PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21462

Query: 967   AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEF 1023
               +    + L W D+      +E   + ++ ++RN    + ++        Y+   L E 
Sbjct: 21463 VTS--DGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 21519

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
               Y FR+ A + AG    S+   F+   S       P    +   +  + W   P   G 
Sbjct: 21520 LDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP-PLRDGG 21578

Query: 1084  P--VNYILQVLVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
                V Y ++   G E   +  +    E  + ++GL     Y FR+ A        +   G
Sbjct: 21579 SKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA--------RNAVG 21630

Query: 1141  AFSPSAAFVLQRSEVMLTGD 1160
               SP +    Q S +++T D
Sbjct: 21631 TISPPS----QSSGIIMTRD 21646



 Score =  128 bits (322), Expect = 3e-29
 Identities = 231/931 (24%), Positives = 352/931 (37%), Gaps = 155/931 (16%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+ SNI   ++ L+WA P         G S    Y +   +K      K+I      E  
Sbjct: 21853 PEPSNITGNSITLTWARPES------DGGSEIQQYILERREKKSTRWVKVISKRPISETR 21906

Query: 342   LK--DLRPATDYHVRVYAMYNSVKG---------SCSEPVSFTTHSCAPECPFPPKLAHR 390
              K   L    +Y   V A   +  G          C EPV+       P  P   K+   
Sbjct: 21907 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVN------PPGPPTVVKVTDT 21960

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYT 448
             SK++++L+W  P+ D G +I  Y++E  +       +       K    +T L     Y 
Sbjct: 21961 SKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYK 22020

Query: 449   FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGIT-------- 489
             FR++A N  G  G S EV   T+  + ++ +AP L           VRAG +        
Sbjct: 22021 FRVSAINGAG-KGDSCEVTG-TIKAVDRL-TAPELDIDANFKQTHVVRAGASIRLFIAYQ 22077

Query: 490   ---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKF 546
                  T  WSKP+           L ++ D +        T    T TV+N  R+   K+
Sbjct: 22078 GRPTPTAVWSKPDS---------NLSLRADIHT-------TDSFSTLTVENCNRNDAGKY 22121

Query: 547   RLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
              LT  N  G KS    V V     D PGPP  P+    VT    ++ WD P  +GG+ I 
Sbjct: 22122 TLTVENNSGSKSITFTVKVL----DTPGPP-GPITFKDVTRGSATLMWDAPLLDGGARIH 22176

Query: 606   KYLLEITDGNSEANQWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLP 663
              Y++E  + +  +  W+V  S   T   F    L  G  Y  R   ++  G     E   
Sbjct: 22177 HYVVEKREASRRS--WQV-ISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYG---VGEPYE 22230

Query: 664   VRTLSIAPGQCRPPR---VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASE 719
             +    +A  Q  PPR   V+   K   V L W  P  + G  ++ Y +EM +   D   E
Sbjct: 22231 MPEPIVATEQPAPPRRLDVVDTSKSSAV-LAWLKPDHDGGSRITGYLLEMRQKGSDFWVE 22289

Query: 720   VYHGPELECTVGNLLPGTVYRFRVRALNDGGYG-----------------PYSDVSEITT 762
               H  +L  TV  L+  T Y FRV+A ND GY                  P +D++ IT 
Sbjct: 22290 AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN 22349

Query: 763   -----AAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHG 817
                   AG P     P IS  P     V W+        + E RL   ++ + + +    
Sbjct: 22350 QLITCKAGSPFTIDVP-ISGRP--APKVTWK--------LEEMRL---KETDRVSITTTK 22395

Query: 818   TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDA 877
               T   ++D +        L   N AG   +S  V+       P PV+        P++ 
Sbjct: 22396 DRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV---IGRPGPVT-------GPIEV 22445

Query: 878   YPDSPSACLVLNWEEPCN-NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT------ 930
                S  +C VL+W EP +  G+EI  Y ++  ++  T        +K    + T      
Sbjct: 22446 SSVSAESC-VLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYM 22504

Query: 931   -YRIRIQAINEIGAG-PFSQFIKAKTRPL--PPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              Y  R+ + N  G   P          P   P  P R E       ++ ++W +      
Sbjct: 22505 EYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRW-EEPYHDG 22563

Query: 987   AAEDIVYTLQLEDRNK-RFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              ++ I Y ++ ++RN   ++   + P     YKV  L E   Y FR  A + AG    SE
Sbjct: 22564 GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASE 22623

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQ----VLVGRES 1097
                    ++       P VT +  ++  ++W + P+  G    V YI++      VG   
Sbjct: 22624 ASRPIMAQNPVDAPGRPEVTDVTRSTVSLIW-SAPAYDGGSKVVGYIIERKPVSEVGDGR 22682

Query: 1098  EYKQVYK-GEEATFQISGLQTNTDYRFRVCA 1127
               K  Y    +  F ++ L     Y FRV A
Sbjct: 22683 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLA 22713



 Score =  128 bits (321), Expect = 4e-29
 Identities = 204/914 (22%), Positives = 339/914 (37%), Gaps = 102/914 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             +V D  +  +K QV ++    V L W PP+        G S   +Y +   D  +     
Sbjct: 21056 KVLDTPAACQKLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWSV 21109

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---L 387
             + +        L DL   T +  RV A  N +     EP   T    A E P P +   +
Sbjct: 21110 VSHKCSSTSFKLIDLSEKTPFFFRVLAE-NEI--GIGEPCETTEPVKAAEVPAPIRDLSM 21166

Query: 388   AHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
                +K+S+ L W  P  D GS IT Y++E  +GK    +           ++++L     
Sbjct: 21167 KDSTKTSVILSWTKPDFDGGSVITEYVVE-RKGKGEQTWSHAGISKTCEIEVSQLKEQSV 21225

Query: 447   YTFRLAARNDIGTSG-------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPE 499
               FR+ A+N+ G S          +E++     ++  +P A   VR G     +    P 
Sbjct: 21226 LEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHN---VHLELPY 21282

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
                P+  I++  +    +         T   +T ++KN K+    K+ +   N     C 
Sbjct: 21283 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV---CR 21339

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V +   +   P  P  P+    + +    + WD P+DNGG EI  Y +E  +  S+ N
Sbjct: 21340 IAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE-TSQTN 21398

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
                V  S + T +   +L     Y+ R    +  G SQ      V ++ +A  Q R P  
Sbjct: 21399 WKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL----VSSIIVAKHQFRIPGP 21454

Query: 680   LGRPKHKEV-----HLEWDVPASESGCEVSEYSVEMTEP-----EDVASEVYHGPELECT 729
              G+P    V      L WD P  + G EV+ + VE  E      + V +    G E   T
Sbjct: 21455 PGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRAT 21514

Query: 730   VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES 789
                L+ G  Y+FRV A N  G    SD S+ T A  P      P         + + W  
Sbjct: 21515 --GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP 21572

Query: 790   P-DSSGADISEYRLEWGEDEESLEL--IYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAG 846
             P    G+ I  Y +E  +  E          ++ ++ +  L P  +Y  R+ A N  G  
Sbjct: 21573 PLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT- 21631

Query: 847   PYSELVLCQTPASAPDPVSTLCVLEEE---PLDAYPDSPSACLVLNWEEPC--------- 894
                         S P   S + +  +E   P+  +       L++   E           
Sbjct: 21632 -----------ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGR 21680

Query: 895   --------NNGSEI-----LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEI 941
                      +G EI     +  T  LG TS+ V        +D   +      ++A N  
Sbjct: 21681 PVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFV--------RDATRDHRGVYTVEAKNAS 21732

Query: 942   GAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
             G+      +K +  P   + P       G +     W D+      A    Y ++  + +
Sbjct: 21733 GSAKAEIKVKVQDTPGKVVGPIRFTNITGEK--MTLWWDAPLNDGCAPITHYIIEKRETS 21790

Query: 1002  KRFISIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PF-SETYTFSTTKSVPPTI 1057
             +   ++   +  + +Y   +L     Y FR+ A ++ G G P  S+        +VP   
Sbjct: 21791 RLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAP 21850

Query: 1058  KAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG---EEATFQIS 1113
               P  + + GNS  + W    S  G  +  YIL+    + + + +V       E  F+++
Sbjct: 21851 GIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVT 21910

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y F V A
Sbjct: 21911 GLTEGNEYEFHVMA 21924



 Score =  126 bits (317), Expect = 1e-28
 Identities = 220/925 (23%), Positives = 347/925 (37%), Gaps = 120/925 (12%)

Query: 283  QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
            + S+I   +  L+W PP         G +    Y +   + GR     ++    +L   +
Sbjct: 8182 KASDITKSSCKLTWEPP------EFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTV 8235

Query: 343  KDLRPATDYHVRVYAMYNSVKGS----CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
            KDL P  +Y  RV A+ N V G        PV        P+ P   ++ + +  ++T+ 
Sbjct: 8236 KDLIPNGEYFFRVKAV-NKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTIT 8294

Query: 399  WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG------YTFRL 451
            WK P+ D GSKI  Y++E    K    +++C     +H        A G      Y FR+
Sbjct: 8295 WKPPLYDGGSKIMGYIIE-KIAKGEERWKRC----NEHLVPILTYTAKGLEEGKEYQFRV 8349

Query: 452  AARNDIGTSGYSQ--------------EVVCYTLGNIPQMPS-APRLVRAGITWVTLQWS 496
             A N  G S  S+              +V+  T   + +    A     +G  + T+ W 
Sbjct: 8350 RAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWI 8409

Query: 497  KPEG-CSPEEVITYTL--------EIQEDE------NDNLFHPKYTGEDLTCTVKNLKRS 541
            K E    PEE+             E+QE+E         L        +    V++  R 
Sbjct: 8410 KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRP 8469

Query: 542  TQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
                + +   N  G    P  V V     D PGPP    V   +       KW+PP D+G
Sbjct: 8470 DHGLYMIKVENDHGIAKAPCTVSVL----DTPGPPIN-FVFEDIRKTSVLCKWEPPLDDG 8524

Query: 601  GSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
            GSEI+ Y LE  D     ++W V  S     +Y+ T L  G  Y  R    +  G     
Sbjct: 8525 GSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPC 8584

Query: 660  ESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYSVEMTEPE 714
             S P+    +A     PP    +P  ++V      ++W+ P  ++G  +  Y +E  E  
Sbjct: 8585 VSKPL----VAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEP-KDNGSPILGYWLEKREVN 8639

Query: 715  DVA-SEVYHG--PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPG 768
                S V       L+  V  LL G  Y FRV A N  G G +S  S+  TA     PPG
Sbjct: 8640 STHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPG 8699

Query: 769  QCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL--------EWGEDEESLELIYHGTD 819
                P ++ T    + + WE P  + G +I  Y +        EW    E +  +     
Sbjct: 8700 P-PIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKV----- 8753

Query: 820  TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPASAPDPVSTLCVLEEEPLDA 877
             ++ ++++   A Y  R+ A N AG GP  E   V    P   P     + V     + A
Sbjct: 8754 RQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMA 8813

Query: 878  YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTY 931
                    +V     P         +T + G+          VG  +  ++KD L +   
Sbjct: 8814 GKTLRIPAVVTGRPVPTK------VWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHG 8867

Query: 932  RIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
            R  I A N  G+   +  ++    P P L   L+      +   L W D       +E  
Sbjct: 8868 RYVITATNSCGSKFAAARVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPED-DGGSEIT 8924

Query: 992  VYTLQLEDRNKRFISIYRGPSHTYK----VQRLTEFTCYSFRIQAASEAGEGPFSETYTF 1047
             + ++ +D     +  +R P  T +    +  L E   Y FR+ A ++ G GP  E    
Sbjct: 8925 GFIIERKDAK---MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPI 8981

Query: 1048 STTKSVPPTIKAPRVTQLEGNSCEIL--WETVPSMKGDPV-NYILQVLVGRESEYKQVYK 1104
                 + P     R+T  E     I   W+   S  G P+  YI++     + ++++V K
Sbjct: 8982 LAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNK 9041

Query: 1105 G--EEATFQISGLQTNTDYRFRVCA 1127
                  +F +  L  +  Y FRV A
Sbjct: 9042 RLCPTTSFLVENLDEHQMYEFRVKA 9066



 Score =  126 bits (316), Expect = 1e-28
 Identities = 195/799 (24%), Positives = 300/799 (37%), Gaps = 105/799 (13%)

Query: 391   SKSSLTLQWKAPIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +K  + + WK P+D+ GSKITNY++E  E  ++         ++  CK++KL     Y F
Sbjct: 10620 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIF 10679

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKP-EGCSPEEV 506
             R+ A N  G S    S  +       +P  P  P +         + W+KP +G  P  +
Sbjct: 10680 RIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP--I 10737

Query: 507   ITYTLEIQEDEN-------DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG---K 556
               Y LE +E  +        +  HP YT       V +L    QY+FR++A N  G    
Sbjct: 10738 TNYILEKRETMSKRWARVTKDPIHP-YT----KFRVPDLLEGCQYEFRVSAENEIGIGDP 10792

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
             S PS+ +       +P PP  P      T +   + W PP+ +GGS+IL Y++E      
Sbjct: 10793 SPPSKPVFAKDPIAKPSPPVNPEAI-DTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10851

Query: 617   EANQWEVA----YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPG 672
             E  +W  A     S   T+Y  T L+ G  YK R   ++  G    S+   V    +   
Sbjct: 10852 E--EWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKD 10906

Query: 673   QCRPPRV-----LGRPKHKEVHLEWDVPASESGC---EVSEYSVEMTEPEDVASEVYH-G 723
             +  PP +     + R +H +V     + A   G    +V+    +   P     +V   G
Sbjct: 10907 RLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVG 10966

Query: 724   PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCV 783
              +LE        G +Y   V   N  G    S    +    GPP   +   I    D C 
Sbjct: 10967 SKLEIRNAAHEDGGIYSLTVE--NPAGSKTVSVKVLVLDKPGPPRDLEVSEI--RKDSCY 11022

Query: 784   LVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFN 841
             L   E  D  G+ I+ Y +E  +   +       T  +     + L    QY  R+ A N
Sbjct: 11023 LTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAEN 11082

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEE--EPLDA-YPDSPSACLVLNWEEP-CNNG 897
             Q G GP+ E          P P+  L  L     P D  + D     + L W +P  + G
Sbjct: 11083 QYGRGPFVE---------TPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGG 11133

Query: 898   SEILAYTIDLGDTSI-------TVGNTTMHVMKDLLPETTYRIRIQAINEIGAG-PFSQF 949
             S I  Y ++  +          TV N    V+  L    TYR R++A N +G G P +  
Sbjct: 11134 SPITGYLVEYQEEGTQDWIKFKTVTNLEC-VVTGLQQGKTYRFRVKAENIVGLGLPDTTI 11192

Query: 950   -IKAKTRPLPP-----------------LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
              I+ + + +PP                    R      G      KW    S+    E  
Sbjct: 11193 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEH- 11251

Query: 992   VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK 1051
              YT++ ++            S    ++         ++I  ++ AG           T  
Sbjct: 11252 -YTVETDNF-----------SSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVL 11296

Query: 1052  SVPPTIKAP-RVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
              VP     P  +  +      I W+      G PV NYI++    R+  +  V  G   T
Sbjct: 11297 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11356

Query: 1110  -FQISGLQTNTDYRFRVCA 1127
               +I  LQ   +Y FRV A
Sbjct: 11357 KLKIPHLQKGCEYVFRVRA 11375



 Score =  125 bits (315), Expect = 2e-28
 Identities = 151/597 (25%), Positives = 233/597 (39%), Gaps = 48/597 (8%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS I+  +  L+W  P+        G S   +Y V   D        +  + ++     
Sbjct: 11012 EVSEIRKDSCYLTWKEPLD------DGGSVITNYVVERRDVASAQWSPLSATSKKKSHFA 11065

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR---SKSSLTLQW 399
             K L     Y  RV A     +G   E             P PPK  H     K+ ++L W
Sbjct: 11066 KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVW 11125

Query: 400   KAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
               P  D GS IT YL+E+ E +    + +    +   C +T L     Y FR+ A N +G
Sbjct: 11126 NKPDRDGGSPITGYLVEYQE-EGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVG 11184

Query: 459   TS--GYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCSPEEVITYTLEIQ 514
                   +  + C      P +    +L+   +     T+++       P     +T +  
Sbjct: 11185 LGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGS 11244

Query: 515   EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGP 574
             E + D  +  +        T+KN  R    ++++T SN  G      V V  T  D PGP
Sbjct: 11245 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKT---VAVHLTVLDVPGP 11301

Query: 575   PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA-TEYT 633
             PT P+    VT    ++ W PPKD+GGS ++ Y++E  D  +  + W V  SGS+ T+  
Sbjct: 11302 PTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQD--TRKDTWGVVSSGSSKTKLK 11359

Query: 634   FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV----- 688
               HL+ G  Y  R    +  G     +S P    ++A  +  PP   G+P   ++     
Sbjct: 11360 IPHLQKGCEYVFRVRAENKIGVGPPLDSTP----TVAKHKFSPPSPPGKPVVTDITENAA 11415

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP--ELECTVGNLLPGTVYRFRVRAL 746
              + W +P S+ G  ++ Y +E  E       V   P  +L+  V  L  G  Y FRV A 
Sbjct: 11416 TVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 11475

Query: 747   NDGGY---GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRL 802
             N  G     P SD  +      PPG    P +         + W  P    G+ I  Y +
Sbjct: 11476 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVV 11535

Query: 803   E--------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL 851
             E        W    +  ELI       F +  L+   +Y  R++A N  G G   EL
Sbjct: 11536 ECQKPGTAQWNRINKD-ELI---RQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 11588



 Score =  125 bits (313), Expect = 3e-28
 Identities = 187/810 (23%), Positives = 304/810 (37%), Gaps = 46/810 (5%)

Query: 351   YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKI 409
             + VR    Y       SEP+        P  P  P+     K  + +QW  P  D G++I
Sbjct: 22907 FRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEI 22966

Query: 410   TNYLLEWDEGK--RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQE-- 465
             +NYL++  E K  R +   + +       K+T L     Y FR+ A N  G S  S+   
Sbjct: 22967 SNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASN 23026

Query: 466   -VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLF-- 522
              + C      P  PSAPR+V      ++L W+KP      +++ Y LE+QE + D  +  
Sbjct: 23027 FISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRV 23086

Query: 523   HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPL--- 579
             H   T  +   TV +LK   +Y FR+ A N +G S  SE +      +R   P   L   
Sbjct: 23087 HTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADD 23146

Query: 580   VKGPVTSH-GFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
             +K  VT   G S++           ++ +  +  D  S A         +   Y+   + 
Sbjct: 23147 LKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA------IIDTTESYSLLIVD 23200

Query: 639   PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
                 Y      I     S    +  +  +   PG C P   +       V + W++P  +
Sbjct: 23201 KVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPC-PSVKVKEVSRDSVTITWEIPTID 23259

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGP 753
              G  V+ Y VE  E    A   +     +C+     +  L+ GT+Y FRV   N  G G 
Sbjct: 23260 GGAPVNNYIVEKRE---AAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE 23316

Query: 754   YSDVSE-ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEW---GEDE 808
               + S+ +  +  P    K   +  T    V + WE P    G+ ++ Y LE    G + 
Sbjct: 23317 PCETSDAVLVSEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGTER 23375

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPD-PVSTL 867
                 +    T     +  L    QY  R++A N+ G     E V   T       P   L
Sbjct: 23376 WMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDL 23435

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLP 927
               + ++ +      P   ++     P    S   A +       +TV  T   V K  + 
Sbjct: 23436 STMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTV-ETHTKVAKLTIR 23494

Query: 928   ETTYRIRIQAINEIG--AGPFSQFIKA--KTRPLPPLPPRLECAAAGPQSLKLKWGDSNS 983
             ETT R   +   E+    G  S+ IK     +P PP  P ++       S+ + W     
Sbjct: 23495 ETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEIDATSITISWEPPEL 23553

Query: 984   KTHAAEDIVYTLQLEDRNKRFISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPF- 1041
                A        Q +     ++ +    +  T+K  RLTE   Y FR+ A +  G G + 
Sbjct: 23554 DGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYL 23613

Query: 1042  -SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              SE     ++  +P   +  ++  +  +   + W       G  V  YI++    R   +
Sbjct: 23614 QSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23673

Query: 1100  KQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
              +V K       ++ +GL    +Y  RV A
Sbjct: 23674 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTA 23703



 Score =  122 bits (307), Expect = 2e-27
 Identities = 153/606 (25%), Positives = 230/606 (37%), Gaps = 68/606 (11%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             + P PP+   +    K S  L W+ PI D G+K+ NY+++  E  R +        S+  
Sbjct: 17809 DTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTS 17868

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW 495
              K+  L     Y FR+ A N+ G     + V        P  P    L     T  +L W
Sbjct: 17869 FKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMW 17928

Query: 496   SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
              KPE      V+ Y +E+Q    +         E   C   V  L    +Y+FR+ A N 
Sbjct: 17929 EKPEHDGGSRVLGYVVEMQPKGTEKW---SIVAESKVCNAVVTGLSSGQEYQFRVKAYNE 17985

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVKWDPPKDNGGSEILKYLL 609
             +GKS P  + V   + D      +P +K P  ++    G  +K + P        + +  
Sbjct: 17986 KGKSDPRVLGVPVIAKDLT---IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISW-- 18040

Query: 610   EITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS-TGGHSQCSESLPVRTLS 668
              + DG        V    +AT  T  H+K G         ++ T      +E+L V  L 
Sbjct: 18041 -VKDGEPLKQTTRVNVEETATS-TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 18098

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC 728
               PG    P          V + W+ PA   GC++S Y VE  +       +        
Sbjct: 18099 -KPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVART 18157

Query: 729   TVG--NLLPGTVYRFRVRALNDGGYGPYSDVSEITTA-----AGPPGQCKAPCISCTPDG 781
             T+    L  GT Y+FR+ A N  G     D   +         GPPG    P ++     
Sbjct: 18158 TIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPG---TPFVTSISKD 18214

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRL 837
              +LV W  P +  G  I  Y LE  E    L +  + T   DT+F+   L    +Y  ++
Sbjct: 18215 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18274

Query: 838   QAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV------LNWE 891
              A N  G G              P  VS  C +  +P D  P  P A ++      L W+
Sbjct: 18275 SAENIVGIG-------------KPSKVSE-CFVARDPCDP-PGRPEAIVITRNNVTLKWK 18319

Query: 892   EPC-NNGSEILAYTIDLGD--------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
             +P  + GS+I  Y ++  D         S T    T   +  L+ +  Y  R+ A N   
Sbjct: 18320 KPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARN--A 18377

Query: 943   AGPFSQ 948
             AG FS+
Sbjct: 18378 AGNFSE 18383



 Score =  121 bits (304), Expect = 3e-27
 Identities = 199/899 (22%), Positives = 328/899 (36%), Gaps = 99/899 (11%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+ + A    L+W PP+        G +    Y +   +  R    ++    + L   +
Sbjct: 18505 KVTGVTAEKCYLAWNPPL------QDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKV 18558

Query: 343   KDLRPATDYHVRVYAM--YNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L P  +Y  RV A+  Y   +   S PV+       P  P  P+++  +K S+ + W 
Sbjct: 18559 TKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWA 18618

Query: 401   APIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPAMGYTFRLAARNDI 457
              P+D+ G++I  Y+LE    K    + +C   +    +L  T L     Y FR+AA N  
Sbjct: 18619 RPVDDGGTEIEGYILE-KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAA 18677

Query: 458   GTSGYSQEVVCYTLGNI---PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
             G    S+  V Y   +    P  PS P++     + V+L WSKP       V  Y +E++
Sbjct: 18678 GVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVK 18737

Query: 515   EDEND--NLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
             E   D      P    +    TV  LK +T+Y FR+ A N+EG   P+ +     + +R 
Sbjct: 18738 EAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERI 18797

Query: 573   GPPTRPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
              PP   L   ++  V                 S  L+  + I        +WE A  G  
Sbjct: 18798 EPPEIELDADLRKVVVLR-------------ASATLRLFVTIKGRPEPEVKWEKA-EGIL 18843

Query: 630   TE-------YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             T+        +FT L    + +  +   +    +          + +      P  +  R
Sbjct: 18844 TDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR 18903

Query: 683   PKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPG 736
                K+ V L W+ P  + G +++ Y VE  E      + Y      CT     + NL  G
Sbjct: 18904 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRE---TTRKAYATITNNCTKTTFRIENLQEG 18960

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS-SGA 795
               Y FRV A N+ G G  ++ +E    + PP       +         + WE P+S  G+
Sbjct: 18961 CSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGS 19020

Query: 796   DISEYRLEW-GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVL- 853
              I+ Y +E   +  E              I  L    +Y  R+ A N+ G     +L + 
Sbjct: 19021 KITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVP 19080

Query: 854   -----CQTPASAPDPVSTLCVLEEEPLD---AYPDSPSACLVLNWEEPCNNGSEILAYTI 905
                   +   S   P  T  V   E L     +   P A   +NW +      E     +
Sbjct: 19081 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQA--TVNWRKDGQTLKETTRVNV 19138

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                 T       T   +K+   E      +   N  G+      I    RP PP P R++
Sbjct: 19139 SSSKT------VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRID 19192

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFT 1024
               +    S+ + W                 + E  +  +  + +  + T  K+ RLT  +
Sbjct: 19193 EVSC--DSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGS 19250

Query: 1025  CYSFRIQAASEAGEGPFSET------YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
              Y FR+ A +  G+  +SE+      Y FS     P     P+V     ++  + W+   
Sbjct: 19251 EYQFRVCAENRYGKSSYSESSAVVAEYPFSP----PGPPGTPKVVHATKSTMLVTWQV-- 19304

Query: 1079  SMKGDPVNYILQVLVGRESEYKQ----------VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  PVN     ++G   EYK+               +   ++SGL     Y +RV A
Sbjct: 19305 -----PVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYA 19358



 Score =  119 bits (298), Expect = 2e-26
 Identities = 205/920 (22%), Positives = 336/920 (36%), Gaps = 106/920 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D    +   +VS++   +  +SWAPP       + G S    Y V   +  R     
Sbjct: 12389 RVLDTPGPVSDLKVSDVTKTSCHVSWAPP------ENDGGSQVTHYIVEKREADRKTWST 12442

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKL 387
             +    ++   ++ +L P  +Y+ RV A+      V     +PV  +     P+ P   ++
Sbjct: 12443 VTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEV 12502

Query: 388   AHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPA 444
                +K+S TL W  P+ D G+KI  Y+  + E ++ +  R   +   K   L  T L   
Sbjct: 12503 TEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPAD-RWTEYSVVKDLSLVVTGLKEG 12561

Query: 445   MGYTFRLAARNDIGTSGYSQEVVCYTLGN--IPQMPSAPRLVRA-------------GIT 489
               Y FR+AARN +G S   +    Y      +P     P  +               G  
Sbjct: 12562 KKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKP 12621

Query: 490   WVTLQWSKPEGCSPEEVITYT-LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRL 548
               T +W K E    +EV+T + L + + ++ ++             +K++ R     + L
Sbjct: 12622 HPTCKWKKGE----DEVVTSSHLAVHKADSSSIL-----------IIKDVTRKDSGYYSL 12666

Query: 549   TASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYL 608
             TA N+ G       +V     D PGPP  P     + +   S+ W  P ++GGS I  Y+
Sbjct: 12667 TAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYI 12723

Query: 609   LEITDGNSEANQWEVAY-SGSATEYTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVR 665
             +E  D       W  A  S + T      L PG  Y  R    +  G S+   S  +  +
Sbjct: 12724 VEKCD--VSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQ 12781

Query: 666   TLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-----SEV 720
                  P + +  RV  +     + + WD P S+ G  +  Y +E  E   +        +
Sbjct: 12782 FPFGVPSEPKNARVT-KVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL 12840

Query: 721   YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISC 777
                 E  C    L+ G  Y FR+ ALN  G  P S  +E  TA     PPG  K   I  
Sbjct: 12841 VRSTEYPC--AGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPG--KPEVIDV 12896

Query: 778   TPDGCVLVGWESPDSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLP 829
             T     L+        G+ I  Y +E        W     +   I       +    L  
Sbjct: 12897 TKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEE 12953

Query: 830   AAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN 889
              AQY  R  A       P         P+   DPV+ L       +D      S   V  
Sbjct: 12954 KAQYQFRAIARTAVNISP---------PSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 13004

Query: 890   WEEPCNNGS------EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR--------I 935
                 C + +        +++  D G          M + ++L     + +         I
Sbjct: 13005 GTNVCLDATVFGKPMPTVSWKKD-GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTI 13063

Query: 936   QAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
              A N  G+   +  +K   +P PP   ++    +    L  +    +  +     IV   
Sbjct: 13064 TAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKR 13123

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
             +    N   +S    P  +  V++L E   Y FRI A ++ G G   F+E          
Sbjct: 13124 ETSRPNWAQVSA-TVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDP 13182

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGE--EATF 1110
             P     P ++ +  +   + W+      G P+  Y+L+    +   + +V +    E T 
Sbjct: 13183 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTL 13242

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             + +GLQ  T+Y FRV A  +
Sbjct: 13243 KATGLQEGTEYEFRVTAINK 13262



 Score =  118 bits (295), Expect = 4e-26
 Identities = 187/845 (22%), Positives = 322/845 (38%), Gaps = 110/845 (13%)

Query: 351  YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKI 409
            Y ++V   +   K  C+  V  T     P  P         K+S+  +W+ P+D+G S+I
Sbjct: 8474 YMIKVENDHGIAKAPCTVSVLDT-----PGPPINFVFEDIRKTSVLCKWEPPLDDGGSEI 8528

Query: 410  TNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTSG--YSQE 465
             NY LE  +  +          + +HCK  +TKL     Y FR+ A N  G      S+ 
Sbjct: 8529 INYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP 8588

Query: 466  VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP- 524
            +V       P  P  P +       + ++W++P+  +   ++ Y LE +E  + +     
Sbjct: 8589 LVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLEKREVNSTHWSRVN 8647

Query: 525  KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVK 581
            K     L   V  L     Y FR+ A N  G    S PS+          PGPP   +  
Sbjct: 8648 KSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTD 8707

Query: 582  GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP 639
               T+    ++W+PP  NGG EI+ Y ++     +  N+W           +YT   ++ 
Sbjct: 8708 TSSTT--IELEWEPPAFNGGGEIVGYFVDKQLVGT--NEWSRCTEKMIKVRQYTVKEIRE 8763

Query: 640  GTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHL----EWDVP 695
            G  YKLR   ++  G     E+ PV   ++A  Q  P   L       + +       +P
Sbjct: 8764 GADYKLRVSAVNAAGEGPPGETQPV---TVAEPQEPPAVELDVSVKGGIQIMAGKTLRIP 8820

Query: 696  ASESGCEV-----SEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
            A  +G  V     ++   E+ +   V   V  G + E  + + L     R+ + A N  G
Sbjct: 8821 AVVTGRPVPTKVWTKEEGELDKDRVVIDNV--GTKSELIIKDALRKDHGRYVITATNSCG 8878

Query: 751  YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE------ 803
                +   E+    GP    K P +  T     L+ W  P D  G++I+ + +E      
Sbjct: 8879 SKFAAARVEVFDVPGPVLDLK-PVV--TNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 8935

Query: 804  --WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPAS 859
              W +  E+         ++ +I  LL   +Y  R+ A N+ G GP  E+  +L   P  
Sbjct: 8936 HTWRQPIETER-------SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 8988

Query: 860  APDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTI--------DLGDT 910
             P     L          Y +   + + L+W+EP  N GS I  Y I        D    
Sbjct: 8989 PPTSPERL---------TYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERV 9039

Query: 911  SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA--KTRPLPPL-------- 960
            +  +  TT  ++++L     Y  R++A+NEIG    S  +    +   +PP         
Sbjct: 9040 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVR 9099

Query: 961  ----------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
                      P  +     G    K++W  + +      D +   + E        + R 
Sbjct: 9100 GDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE--------VSRS 9151

Query: 1011 PSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
             + T   + +       ++ + A++  G   F   +     +  PP   A  VT ++  S
Sbjct: 9152 EAKTELSIPKAVREDKGTYTVTASNRLG-SVFRNVHVEVYDRPSPPRNLA--VTDIKAES 9208

Query: 1070 CEILWETVPSMKGDPVNYIL---QVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRV 1125
            C + W+      G  + + +   +    +++E+++V     E  + I  L  N  Y FRV
Sbjct: 9209 CYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRV 9268

Query: 1126 CACRR 1130
             A  +
Sbjct: 9269 RAVNK 9273



 Score =  118 bits (295), Expect = 4e-26
 Identities = 181/757 (23%), Positives = 289/757 (38%), Gaps = 115/757 (15%)

Query: 378   APECPFPP-KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             AP  P PP  ++     + +L W  P+ D GS ITNY++E  +  R          ++  
Sbjct: 12686 APGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTS 12745

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
             C++ KL P   Y FR+ A N  G S    S ++V      +P  P   R+ +     + +
Sbjct: 12746 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFV 12805

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTA 550
              W +P+      +I Y +E    E ++L   K     +  T      L    +Y FR+ A
Sbjct: 12806 AWDRPDSDGGSPIIGYLIE--RKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYA 12863

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G S PS+     T+     PP +P V   VT    S+ W  PK +GGS+I+ Y +E
Sbjct: 12864 LNKAGSSPPSKPTEYVTARMPVDPPGKPEVI-DVTKSTVSLIWARPKHDGGSKIIGYFVE 12922

Query: 611   I--TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTL 667
                  G+         +     EYT T L+    Y+ RA   +    S  SE S PV  L
Sbjct: 12923 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12982

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE 727
             +    +  PPR+      K       +   ++G  V   +    +P    S    G  L+
Sbjct: 12983 A----ENVPPRIDLSVAMK------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 13032

Query: 728   CTVG-------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA----------GPPGQC 770
                G       NL   T+  F V   + G Y   ++ S  + +A          GPP   
Sbjct: 13033 PAEGIKMAMQRNLC--TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASV 13090

Query: 771   KAPCISCTPDGCVLVGWESP-DSSGADISEY--------RLEWGEDEESLELIYHGTDTR 821
             K   I+       ++ WE P +  G++I+ Y        R  W +   ++ +      T 
Sbjct: 13091 K---INKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI------TS 13141

Query: 822   FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDS 881
               +  L+   +Y  R+ A N+ G G               DPV T   + + P     D 
Sbjct: 13142 CSVEKLIEGHEYQFRICAENKYGVG---------------DPVFTEPAIAKNPY----DP 13182

Query: 882   PSAC------------LVLNWEEPCNN-GSEILAYTIDLGDTSITVGNTTMHVMKDLLPE 928
             P  C            + ++W+ P ++ GS I  Y ++  +T     N T    K ++  
Sbjct: 13183 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV--NWTKVNRKPIIER 13240

Query: 929   ----------TTYRIRIQAINEIGAGPFSQFIK---AKTRPLPPLPPRL-ECAAAGPQSL 974
                       T Y  R+ AIN+ G G  S   K   A+    PP PP   +       S+
Sbjct: 13241 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13300

Query: 975   KLKWGDS--NSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQ 1031
              L WG    +  +     +V   + +  N    ++ +    T ++V  L E T Y FR+ 
Sbjct: 13301 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 13360

Query: 1032  AASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGN 1068
             A ++ G    S+       K  P  I  P   +L+ +
Sbjct: 13361 AVNKIGYSDPSDV----PDKHYPKDILIPPEGELDAD 13393



 Score =  118 bits (295), Expect = 4e-26
 Identities = 173/749 (23%), Positives = 277/749 (36%), Gaps = 83/749 (11%)

Query: 433   QKHCKLTKLCPAMGYTFRLAARNDIG--------TSGYSQEVVCYTLGNIPQMPSAP-RL 483
             + H K+ KL      T R     D G         +G + E +   + + P  P+ P ++
Sbjct: 23483 ETHTKVAKL------TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI 23536

Query: 484   VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQ 543
                  T +T+ W  PE      +  Y +E ++           +    T     L    +
Sbjct: 23537 DEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNE 23596

Query: 544   YKFRLTASNTEG--KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y FR+ A+N  G      SEV+ C +S   PGPP   L    V+  G ++ W PP+D+GG
Sbjct: 23597 YVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPP-ETLQIFDVSRDGMTLTWYPPEDDGG 23655

Query: 602   SEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE- 660
             S++  Y++E  +  ++          + T Y  T L  G  Y+ R   I+  G  + S  
Sbjct: 23656 SQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRP 23715

Query: 661   SLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED--- 715
             S P+  +     PG+ + PRV    +   V L W VP  E G +V+ Y +EM + +    
Sbjct: 23716 SKPIVAMDPIAPPGKPQNPRVTDTTR-TSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEW 23774

Query: 716   VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCI 775
                        E T+ +L  G  YRFRV A N GG G  ++V         PG  K   +
Sbjct: 23775 TKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEV---------PGTVKVTEM 23825

Query: 776   SCTPD---------------GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDT 820
                PD               G V+            I ++  E  +  +   +    T T
Sbjct: 23826 LEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHT 23885

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGA-GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYP 879
                I++          L   N+ G    Y ++ +  +P S   P+             Y 
Sbjct: 23886 ELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLE------------YD 23933

Query: 880   DSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVGNT-------TMHVMKDLLPETTY 931
             D     + ++W  P ++G ++IL Y ++  +       T       T  V+K L     Y
Sbjct: 23934 DIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEY 23993

Query: 932   RIRIQAINEIGAGP---FSQFIKAKTRPLPPLPPRL--ECAAAGPQSLKLKWGDSNSKTH 986
               R+ A N+ G        + +  KT   PP PP    E       S+ L W        
Sbjct: 23994 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGG 24053

Query: 987   AAEDIVYTLQLEDRNKRFISIYRGPSHT--YKVQRLTEFTCYSFRIQAASEAG---EGPF 1041
             +     Y  + E    +++   +    T  Y V  L     Y FRI A ++ G     P 
Sbjct: 24054 SRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPA 24113

Query: 1042  SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYK 1100
             SE          P       +  +  +S  + WE      G  +  Y ++     +S +K
Sbjct: 24114 SEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWK 24173

Query: 1101  QVYKG--EEATFQISGLQTNTDYRFRVCA 1127
             +  K   ++  F I GL   T+Y FRV A
Sbjct: 24174 KSNKERIKDKQFTIGGLLEATEYEFRVFA 24202



 Score =  117 bits (292), Expect = 9e-26
 Identities = 190/802 (23%), Positives = 298/802 (37%), Gaps = 63/802 (7%)

Query: 368   EPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNS 423
             EP   T    A E P PP    +   +KS+++L W  P  D GSKIT Y++E  + K + 
Sbjct: 14646 EPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIE-AQRKGSD 14704

Query: 424   GFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAP 481
              +          C +  L     YTF++ A N  G S    S+ V+      +P++    
Sbjct: 14705 QWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRG 14764

Query: 482   RLVRAGITWV--TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLK 539
                +  I      ++   P    P+  +T+    Q  +     + + T       +    
Sbjct: 14765 IYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECV 14824

Query: 540   RSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDN 599
             RS    + LTA N  G+    +V+      D PGPPT P+    V+S   +  WDPP+++
Sbjct: 14825 RSDSGPYPLTARNIVGEV--GDVITIQVH-DIPGPPTGPIKFDEVSSDFVTFSWDPPEND 14881

Query: 600   GGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC-----ISTG 653
             GG  I  Y++E+    +++  W E+A +   T Y  T L  G  Y+ R        +  G
Sbjct: 14882 GGVPISNYVVEMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPG 14939

Query: 654   GHSQC-SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE 712
               S C   + P +     PG    P+V    K   + + W  P S+ G  +  Y VE  E
Sbjct: 14940 ITSACIVANYPFK----VPGPPGTPQVTAVTK-DSMTISWHEPLSDGGSPILGYHVERKE 14994

Query: 713   PEDVASEVYHGPELECTV---GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQ 769
                +  +      +   +     L  G  Y FRV A N  G    S  SE   A  P   
Sbjct: 14995 RNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDP 15054

Query: 770   CKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL---IYHGTDTRFEIR 825
                P         V + W  P+ + G  I+ Y +E  +      L     +  +  F + 
Sbjct: 15055 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 15114

Query: 826   DLLPAAQYCCRLQAFNQAGA----GPYSELVLCQTPASAPDP------VSTLCVLEEEPL 875
              L   A Y  R+ A N AGA       S+ + C+    AP          T+ +   E  
Sbjct: 15115 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAF 15174

Query: 876   DAYPD-SPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR 934
                 D S      + W +            I + D S  + N      KD     +    
Sbjct: 15175 RLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVN------KDSTRRDSGAYT 15228

Query: 935   IQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
             + A N  G       +K   RP PP  P L       +   L W        A  D    
Sbjct: 15229 LTATNPGGFAKHIFNVKVLDRPGPPEGP-LAVTEVTSEKCVLSWFPPLDDGGAKIDHYIV 15287

Query: 995   LQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
              + E     + ++      T  KV +L +   Y FR+ A ++ G G P       +    
Sbjct: 15288 QKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPY 15347

Query: 1053  VPP-TIKAPRVTQLEGNSCEILWETVPSMKG-DPVNYILQVLVGRESEYKQVYKGEEAT- 1109
              PP   K P VT +  +S  + W    S  G + +NYI++    R+   ++  K  + T 
Sbjct: 15348 GPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVE---RRDKAGQRWIKCNKKTL 15404

Query: 1110  ----FQISGLQTNTDYRFRVCA 1127
                 +++SGL    +Y FR+ A
Sbjct: 15405 TDLRYKVSGLTEGHEYEFRIMA 15426



 Score =  117 bits (292), Expect = 9e-26
 Identities = 209/903 (23%), Positives = 342/903 (37%), Gaps = 101/903 (11%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             PQV+ +   ++ +SW  P+     P  G      Y V    K R+G      S   +  N
Sbjct: 14960 PQVTAVTKDSMTISWHEPLSDGGSPILG------YHV--ERKERNGILWQTVSKALVPGN 15011

Query: 342   LKDLRPATD---YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +      TD   Y  RV A   + K   S+P          + P  P   + ++ ++TL+
Sbjct: 15012 IFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLK 15071

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRLAARND 456
             W  P    G KIT+Y++E  +       +  F    +    ++ L     Y FR+ A+N 
Sbjct: 15072 WAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNA 15131

Query: 457   IGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITW-----------VTLQWS 496
              G     S  S  + C      P++    +     +++AG  +            T++WS
Sbjct: 15132 AGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS 15191

Query: 497   KPEGCSPEEVITYTLEIQ-EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
             K      E   T  LEI+  D + NL +            K+  R     + LTA+N  G
Sbjct: 15192 KD---GKELEGTAKLEIKIADFSTNLVN------------KDSTRRDSGAYTLTATNPGG 15236

Query: 556   KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
              +   + +      DRPGPP  PL    VTS    + W PP D+GG++I  Y+++  +  
Sbjct: 15237 FA---KHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRE-T 15292

Query: 616   SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQ 673
             S      VA     T+   T L  G  Y  R   ++  G  +  ES PV  ++    P  
Sbjct: 15293 SRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDP 15352

Query: 674   CRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTV 730
              + P V    K   V + W  P S+ G E+  Y VE  +      +        +L   V
Sbjct: 15353 PKNPEVTTITKDSMV-VCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKV 15411

Query: 731   GNLLPGTVYRFRVRALNDGGY------GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVL 784
               L  G  Y FR+ A N  G        P+    +     GPPG    P +  T    + 
Sbjct: 15412 SGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSIS 15468

Query: 785   VGWESP-DSSGADISEYRLEWG---EDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQA 839
             + W  P    G++I+ Y +E     EDE  +     G   T + I  L    +Y  R+ A
Sbjct: 15469 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15528

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSE 899
              N  G G   E  L      A D +    +  +  L       + C +  +       + 
Sbjct: 15529 MNSEGLG---EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAP 15585

Query: 900   ILAYTIDLGDT--SITVGNTTMHVMKDLLPETTYRI---RIQAINEIGAGPFSQFIKAKT 954
              + +  D G++    ++ +T+ + +  L+     R    +     E  +G  S F+  + 
Sbjct: 15586 EVKWARDHGESLDKASIESTSSYTL--LIVGNVNRFDSGKYILTVENSSGSKSAFVNVRV 15643

Query: 955   RPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
                P  P  L+       S+ L W      G S  K +  E      + E   K + ++ 
Sbjct: 15644 LDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE------KRESTRKAYSTVA 15697

Query: 1009  RGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE- 1066
                  T +KV +L E   Y FR+ A +E G G  +E  T  + K+    +   ++T ++ 
Sbjct: 15698 TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE--TAESVKASERPLPPGKITLMDV 15755

Query: 1067  -GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFR 1124
               NS  + WE      G  +  YI+++      ++      +     I+GL    +Y FR
Sbjct: 15756 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFR 15815

Query: 1125  VCA 1127
             V A
Sbjct: 15816 VSA 15818



 Score =  115 bits (288), Expect = 3e-25
 Identities = 177/727 (24%), Positives = 291/727 (40%), Gaps = 108/727 (14%)

Query: 384   PPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFR--QCFFGSQKHC--KL 438
             P +++  S  S  L W  P D G ++ITNY++E    KR SG    Q    S K    K+
Sbjct: 22442 PIEVSSVSAESCVLSWGEPKDGGGTEITNYIVE----KRESGTTAWQLVNSSVKRTQIKV 22497

Query: 439   TKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS 496
             T L   M Y+FR+++ N  G S    S  ++       P  P+ P +       ++++W 
Sbjct: 22498 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22557

Query: 497   KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTE 554
             +P      ++I Y +E +++ N  L+  +     L C  K   L    +Y+FR  A N  
Sbjct: 22558 EPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAA 22616

Query: 555   GKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE---- 610
             G S  SE      + +    P RP V   VT    S+ W  P  +GGS+++ Y++E    
Sbjct: 22617 GVSKASEASRPIMAQNPVDAPGRPEVTD-VTRSTVSLIWSAPAYDGGSKVVGYIIERKPV 22675

Query: 611   --ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGH-SQCSESLPVRTL 667
               + DG      + +    S   +T T L  G  Y+ R    +  G  S+ SES      
Sbjct: 22676 SEVGDGRWLKCNYTIV---SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST----- 22727

Query: 668   SIAPGQCR----PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE--------- 714
                P  CR    PP+        +  L  D+    +G ++   +    +PE         
Sbjct: 22728 --GPVTCRDEYAPPKA-----ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGD 22780

Query: 715   ---DVASEV---YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPG 768
                D+  +V   Y G      +         ++ +   N  G    S + ++  + GP G
Sbjct: 22781 KELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCG 22840

Query: 769   QCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT--DTRFEIR 825
             +     +  T + C L  W  P +  GA+I+ Y +E  E      +I  G      + + 
Sbjct: 22841 KLTVSRV--TQEKCTLA-WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVT 22897

Query: 826   DLLPAAQYCCRLQAFNQAGAGP--YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPS 883
              L+   +Y  R++A N+ G G    SE ++ +   + P P      + EE       +  
Sbjct: 22898 RLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG----IPEEV-----GTGK 22948

Query: 884   ACLVLNWEEP-CNNGSEILAYTIDLGDTS----------ITVGNTTMHVMKDLLPETTYR 932
               +++ W +P  + G+EI  Y +D  +              V +T + V   L+    Y+
Sbjct: 22949 EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTS-LMEGCDYQ 23007

Query: 933   IRIQAINEIG---AGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              R+ A+N  G       S FI  +     P PP  PR+        S+ L W  +     
Sbjct: 23008 FRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV--VDTTKHSISLAW--TKPMYD 23063

Query: 987   AAEDIV-YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTC--------YSFRIQAASEAG 1037
                DIV Y L++++++      YR   HT    R TEFT         YSFR+ A +  G
Sbjct: 23064 GGTDIVGYVLEMQEKDTD--QWYR--VHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 23119

Query: 1038  EGPFSET 1044
                +SE+
Sbjct: 23120 MSEYSES 23126



 Score =  114 bits (284), Expect = 7e-25
 Identities = 219/964 (22%), Positives = 367/964 (38%), Gaps = 124/964 (12%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             EKP+VSN+      +SW  PV        G S    Y V   +K      + I +   +L
Sbjct: 14271 EKPEVSNVTKNTATVSWKRPVD------DGGSEITGYHVERREKKSLRWVRAIKTPVSDL 14324

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH---RSKSSL 395
              C +  L+  + Y  RV A   +  G  SE         A   P PP   H    +K S 
Sbjct: 14325 RCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSA 14384

Query: 396   TLQWKAP-IDNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
             +L W  P  D G +IT Y++E        W +    +  R   F       +  L     
Sbjct: 14385 SLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQF------VVPDLQTKEK 14438

Query: 447   YTFRLAARNDIGTSGYSQ----EVVCYTLGNIPQMPSAPR---LVRAGITWVTLQWSKPE 499
             Y FR++A ND G    +     E+V   +    ++ +  R   +VRAG++   ++   P 
Sbjct: 14439 YNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLS---IRIFVPI 14495

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQY---KFRLTASNTEGK 556
                P   +T+T      +N NL +        + T+  +    +Y   KF +T  N  GK
Sbjct: 14496 KGRPAPEVTWT-----KDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK 14550

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
                    V     D PGP    L    +T    ++ WD P  +GGS I  Y++E  +   
Sbjct: 14551 KSG---FVNVRVLDTPGPVLN-LRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATR 14606

Query: 617   EANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
             ++           T Y  T L  G  Y  R    +  G  + +E+      S AP     
Sbjct: 14607 KSYSTATTKCHKCT-YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS 14665

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLP 735
               ++   K   V L W  P  + G +++ Y +E   +  D  + +     LEC V NL  
Sbjct: 14666 LNIMDITK-STVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14724

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             G  Y F+V A+N  G     +   +        Q   P +        LV  ++ D+   
Sbjct: 14725 GEEYTFQVMAVNSAGRSAPRESRPVIVKE----QTMLPELDLRGIYQKLVIAKAGDNIKV 14780

Query: 796   DI-----SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
             +I      +  + W + ++ L+         FE      A      +    ++ +GPY  
Sbjct: 14781 EIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVRSDSGPYP- 14832

Query: 851   LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP-------SACLVLNWEEPCNNGS-EILA 902
                  T  +    V  +  ++   +   P  P       S  +  +W+ P N+G   I  
Sbjct: 14833 ----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISN 14888

Query: 903   YTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKA 952
             Y +++  T        + TV  TT    + L     Y+ R++A N  G GP   S  I A
Sbjct: 14889 YVVEMRQTDSTTWVELATTVIRTTYKATR-LTTGLEYQFRVKAQNRYGVGPGITSACIVA 14947

Query: 953   KTRPLPPLPPRL-ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIY 1008
                   P PP   +  A    S+ + W +  S    +  + Y ++ ++RN    + +S  
Sbjct: 14948 NYPFKVPGPPGTPQVTAVTKDSMTISWHEPLS-DGGSPILGYHVERKERNGILWQTVSKA 15006

Query: 1009  RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEG 1067
               P + +K   LT+   Y FR+ A + AG+  P   +        + P  K P    +  
Sbjct: 15007 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK-PVPLNITR 15065

Query: 1068  NSCEILWETVPSMKGDPV-NYILQ---VLVGR--ESEYKQVYKGEEATFQISGLQTNTDY 1121
             ++  + W       G  + +YI++   +  GR  ++ +  + + E   F +SGL  +  Y
Sbjct: 15066 HTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE---FTVSGLTEDAAY 15122

Query: 1122  RFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAA 1181
              FRV A        +  +GA SP +    + S+ +   D   ++ PK+K     D +F  
Sbjct: 15123 EFRVIA--------KNAAGAISPPS----EPSDAITCRD--DVEAPKIK----VDVKFKD 15164

Query: 1182  IIVL 1185
              ++L
Sbjct: 15165 TVIL 15168



 Score =  113 bits (283), Expect = 1e-24
 Identities = 196/861 (22%), Positives = 330/861 (38%), Gaps = 95/861 (11%)

Query: 325   RDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMY---NSVKGSCSEPVSFTTHSCAPEC 381
             R  K  ++Y   +    +  L    DY  RV A+    NS     S  +S    S  P  
Sbjct: 22983 RVNKDYVVY---DTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGP 23039

Query: 382   PFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK 440
             P  P++   +K S++L W  P+ D G+ I  Y+LE  E   +  +R     + ++ + T 
Sbjct: 23040 PSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23099

Query: 441   LCPAMG--YTFRLAARNDIGTSGYSQ---EVVCYTLGNIPQMPSAPRL-----VRAGITW 490
                 MG  Y+FR+AA N  G S YS+   E+       IP +  A  L     +RAG   
Sbjct: 23100 PDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG--- 23156

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              +L+        P  VIT++ +  +  +  +     T       V  + R    K+ + A
Sbjct: 23157 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT--TESYSLLIVDKVNRYDAGKYTIEA 23214

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  GK   +   V     D PGP     VK  V+    ++ W+ P  +GG+ +  Y++E
Sbjct: 23215 ENQSGKKSAT---VLVKVYDTPGPCPSVKVK-EVSRDSVTITWEIPTIDGGAPVNNYIVE 23270

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC---CISTGGHSQCSESLPVRTL 667
               +    A +  V    S T Y  + L  GT+Y  R         G   + S+++ V  +
Sbjct: 23271 KREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV 23329

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP--EDVASEVYHGPE 725
              + P +     V        V L W+ P  + G  ++ Y +E  +   E     V   P 
Sbjct: 23330 PLVPAKLEVVDVT----KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPT 23385

Query: 726   -LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT------ 778
              LE TV +L  G  Y FR+RA N+ G    S+  E  TA         P I  +      
Sbjct: 23386 VLEHTVTSLNEGEQYLFRIRAQNEKGV---SEPRETVTAVTVQDLRVLPTIDLSTMPQKT 23442

Query: 779   ---PDG-----CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD--LL 828
                P G      + +    P ++    +  +L    + E + +  H    +  IR+  + 
Sbjct: 23443 IHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR---ESERVTVETHTKVAKLTIRETTIR 23499

Query: 829   PAAQYCCRLQAFNQAGAGPYS-ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV 887
                +Y   L+  N  G    + ++++   P     P+        + +DA        + 
Sbjct: 23500 DTGEYTLELK--NVTGTTSETIKVIILDKPGPPTGPIKI------DEIDA------TSIT 23545

Query: 888   LNWEEP-CNNGSEILAYTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAI 938
             ++WE P  + G+ +  Y ++  D         S +V  +T    + L     Y  R+ A 
Sbjct: 23546 ISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTR-LTEGNEYVFRVAAT 23604

Query: 939   NEIGAGPF--SQFIKAKTRPLPPLPPR-LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
             N  G G +  S+ I+ ++    P PP  L+        + L W        +        
Sbjct: 23605 NRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE 23664

Query: 996   QLEDRNKRFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
             + E R  R++ + + P     Y+   LTE   Y  R+ A +  G G P   +        
Sbjct: 23665 RKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDP 23724

Query: 1053  VPPTIKA--PRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQ--VYKGEE 1107
             + P  K   PRVT     S  + W       G  V  Y++++    + E+ +      + 
Sbjct: 23725 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKI 23784

Query: 1108  ATFQISGLQTNTDYRFRVCAC 1128
               + ++ L    +YRFRV AC
Sbjct: 23785 REYTLTHLPQGAEYRFRVLAC 23805



 Score =  112 bits (281), Expect = 2e-24
 Identities = 187/798 (23%), Positives = 293/798 (36%), Gaps = 83/798 (10%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P PP+   ++   K S  L WK P+D+G S ITNY++E  +   ++ +      S+K   
Sbjct: 11005 PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKKSH 11063

Query: 438   LTK-LCPAMGYTFRLAARNDIGTSGYSQE---VVCYTLGNIPQMPSAPRLVRAGITWVTL 493
               K L     Y FR+AA N  G   + +    +      + P  P     V    T V+L
Sbjct: 11064 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 11123

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
              W+KP+      +  Y +E QE+   +    K T  +L C V  L++   Y+FR+ A N 
Sbjct: 11124 VWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAENI 11182

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTR---PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              G   P   +          P       L++G V   G +V++            K+   
Sbjct: 11183 VGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-- 11240

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              TDG SE    E         YT       ++  ++ C     G  Q + S    + ++A
Sbjct: 11241 -TDG-SEIKTDE--------HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVA 11290

Query: 671   --------PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVY 721
                     PG    P  +     + + + W  P  + G  V  Y VE  +  +D    V 
Sbjct: 11291 VHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVS 11350

Query: 722   HGP-ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISC 777
              G  + +  + +L  G  Y FRVRA N  G GP  D S  T A     PP     P ++ 
Sbjct: 11351 SGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLD-STPTVAKHKFSPPSPPGKPVVTD 11409

Query: 778   TPDGCVLVGWESPDSSGAD-ISEYRLEWGEDEESLELIYHG--TDTRFEIRDLLPAAQYC 834
               +    V W  P S G   I+ Y +E  E       +      D +F +  L     Y 
Sbjct: 11410 ITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 11469

Query: 835   CRLQAFNQAGAG---PYSELVLCQTPASAPDPVSTLCVLEEEPLDA-YPDSPSACLVLNW 890
              R+ A N AG     P S+ +    P   P P          P++    D       L W
Sbjct: 11470 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGP----------PINPKLKDKSRETADLVW 11519

Query: 891   EEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKD------------LLPETTYRIRIQA 937
              +P ++G S IL Y ++         N    + KD            L+    YR RI+A
Sbjct: 11520 TKPLSDGGSPILGYVVECQKPGTAQWN---RINKDELIRQCAFRVPGLIEGNEYRFRIKA 11576

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGD-----SNSKTHAAEDIV 992
              N +G G   +  ++        PP +E        + ++ G      +  K     DI 
Sbjct: 11577 ANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDIT 11636

Query: 993   YTLQ--LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             +T +  +  R KR   I   P    +++         + I A + +G    S        
Sbjct: 11637 WTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGS---AIVNV 11693

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
                P   +  +VT +   +C I WE      G  + N+I++     +  +  V       
Sbjct: 11694 LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11753

Query: 1110  FQISGLQTNTDYRFRVCA 1127
                + L  N +Y FRVCA
Sbjct: 11754 LIKANLLANNEYYFRVCA 11771



 Score =  112 bits (279), Expect = 3e-24
 Identities = 202/906 (22%), Positives = 332/906 (36%), Gaps = 95/906 (10%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             + P+V+ +    + + W PP       + G      Y +   +K       +  S   E 
Sbjct: 12095 DPPEVTKVSKEEMTVVWNPP------EYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPER 12148

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSL 395
                +++L P  +Y  RV A      G  S P          E P PP   ++   +K S+
Sbjct: 12149 RMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSI 12208

Query: 396   TLQWKAPI-DNGSKITNYLLEWD----EGKRNSGFRQCFFGSQ---KHCKLTKLCPAMGY 447
             TL W  P+ D G+ I  Y++E      +   + G+++C   +Q   K   +T L     Y
Sbjct: 12209 TLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEY 12268

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR--------LVRAG--ITWVTLQWSK 497
              FR+ A+N +G    ++         I + P            +VRAG  I    +   +
Sbjct: 12269 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 12328

Query: 498   PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS 557
             P        +     +++ + D +    +        + N  R    K+ LT  N  G+ 
Sbjct: 12329 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFL------VIPNSTRDDSGKYSLTLVNPAGEK 12382

Query: 558   CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
                 V V     D PGP +  L    VT     V W PP+++GGS++  Y++E  +  ++
Sbjct: 12383 A---VFVNVRVLDTPGPVS-DLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKRE--AD 12436

Query: 618   ANQWE-VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP-GQCR 675
                W  V      T +  T+L PG  Y  R   ++  G    ++ +P   L+  P  +  
Sbjct: 12437 RKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTD-VPKPVLASDPLSEPD 12495

Query: 676   PPRVL--GRPKHKEVHLEWDVPASESGCEVSEYSV---EMTEPEDVASEVYHGPELECTV 730
             PPR L           L W  P  + G ++  Y     E  +P D  +E     +L   V
Sbjct: 12496 PPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVV 12555

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE-- 788
               L  G  Y+FRV A N  G     +   +  A     Q   P I       +  G +  
Sbjct: 12556 TGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA---KEQLLPPKILMPEQITIKAGKKLR 12612

Query: 789   -SPDSSGADISEYRLEWGEDE--ESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQA 843
                   G      + + GEDE   S  L  H  D+     I+D+         L A N +
Sbjct: 12613 IEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12672

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILA 902
             G       V+       P P          P D       AC  L+W  P  + GS I  
Sbjct: 12673 GTDTQKIKVVVMDAPGPPQP----------PFDISDIDADAC-SLSWHIPLEDGGSNITN 12721

Query: 903   YTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAK 953
             Y ++  D S         +V  T+  V K L+P   Y  R++A N  G + P +      
Sbjct: 12722 YIVEKCDVSRGDWVTALASVTKTSCRVGK-LIPGQEYIFRVRAENRFGISEPLTSPKMVA 12780

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN-----KRFIS 1006
               P  +P  P            + + W D       +  I Y ++ ++RN     K   +
Sbjct: 12781 QFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLIERKERNSLLWVKANDT 12839

Query: 1007  IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
             + R  S  Y    L E   YSFRI A ++AG  P S+   + T +        P V  + 
Sbjct: 12840 LVR--STEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVT 12897

Query: 1067  GNSCEILWETVPSMKGDP-VNYILQVLVGRESEYKQV----YKGEEATFQISGLQTNTDY 1121
              ++  ++W       G   + Y ++       ++ +     ++  +  +  +GL+    Y
Sbjct: 12898 KSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQY 12957

Query: 1122  RFRVCA 1127
             +FR  A
Sbjct: 12958 QFRAIA 12963



 Score =  109 bits (273), Expect = 1e-23
 Identities = 207/916 (22%), Positives = 353/916 (38%), Gaps = 89/916 (9%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             V  ++  +  L W PP+        G +   +Y +   +  R     +     +    ++
Sbjct: 17819 VKEVRKDSAFLVWEPPI------IDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVE 17872

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
             +L     Y+ RV A      G   E V     +  P  P    L   S++S +L W+ P 
Sbjct: 17873 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17932

Query: 404   -DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTS 460
              D GS++  Y++E          +       K C   +T L     Y FR+ A N+ G S
Sbjct: 17933 HDGGSRVLGYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS 17989

Query: 461   G---YSQEVVCYTLGNIP--QMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                     V+   L   P  ++P     ++AG     L+   P    P   I++  + + 
Sbjct: 17990 DPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAG---EDLKIEIPVIGRPRPNISWVKDGEP 18046

Query: 516   DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              +     + + T       +K   +    K+ +TA+N+ G +  +  ++     ++PGPP
Sbjct: 18047 LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL---EKPGPP 18103

Query: 576   TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VAYSGSATEYTF 634
               P+    V++    + W+PP   GG +I  Y++E  D  +    W  V+ + + T    
Sbjct: 18104 VGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRD--TTTTTWHMVSATVARTTIKI 18161

Query: 635   THLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEW 692
             T LK GT Y+ R    +  G S    S+++ V+     PG    P V    K  ++ ++W
Sbjct: 18162 TKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISK-DQMLVQW 18220

Query: 693   DVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDG 749
               P ++ G ++  Y +E  E   +     +   ++ T      L  G  Y F+V A N  
Sbjct: 18221 HEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIV 18280

Query: 750   GYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWG 805
             G G  S VSE   A     PPG+ +A  I+      V + W+ P    G+ I+ Y +E  
Sbjct: 18281 GIGKPSKVSECFVARDPCDPPGRPEAIVIT---RNNVTLKWKKPAYDGGSKITGYIVEKK 18337

Query: 806   E--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAG--------AGPYSELVLC 854
             +  D   ++  +    +T F +  L+   +Y  R+ A N AG        +G  +     
Sbjct: 18338 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEI 18397

Query: 855   QTPASAPDP----VSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
               P ++ DP    V  +   E   L+A     P   +V  W +   +G E L  T    +
Sbjct: 18398 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVV--WSK---DGKE-LEETAARME 18451

Query: 910   TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAA 969
                T+  TT+ V+KD +     +  ++  N  G       +K   RP PP  P L+    
Sbjct: 18452 IKSTIQKTTL-VVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP-LKVTGV 18509

Query: 970   GPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH----TYKVQRLTEFTC 1025
               +   L W   N         +    +E R    +S  +  +      YKV +L     
Sbjct: 18510 TAEKCYLAW---NPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNE 18566

Query: 1026  YSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             Y FR+ A ++ G G   E+   T       P     P V+ +  +S  + W       G 
Sbjct: 18567 YIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGT 18626

Query: 1084  PV-NYILQVLVGRESEYKQVYKGEEAT-----FQISGLQTNTDYRFRVCACRRCLDTSQE 1137
              +  YIL+    R+ E  +  K  + T      +++GL     Y FRV A        + 
Sbjct: 18627 EIEGYILE---KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAA--------EN 18675

Query: 1138  LSGAFSPSAAFVLQRS 1153
              +G   PS   V  R+
Sbjct: 18676 AAGVGEPSEPSVFYRA 18691



 Score =  109 bits (272), Expect = 2e-23
 Identities = 217/913 (23%), Positives = 347/913 (38%), Gaps = 114/913 (12%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+N+      +SW  P  L  G     +F   Y      K     + I+ S        
Sbjct: 11704 KVTNVTKENCTISWENP--LDNGGSEITNFIVEYR-----KPNQKGWSIVASDVTKRLIK 11756

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
              +L    +Y+ RV A      G   E   P+        P  P    +A + K+ + L+W
Sbjct: 11757 ANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKW 11816

Query: 400   KAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK--HCKLTKLCPAMGYTFRLAARND 456
             + P  D GS   +Y +E    K +  + +   GS K  H  + +      Y FR+  +N+
Sbjct: 11817 RRPDYDGGSPNLSYHVE-RRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 11875

Query: 457   IGTSGY--SQEVVCYTLGNIPQMP---SAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
              G S +  ++EVV       P +    S    V+AG T + L+        PE  + +T 
Sbjct: 11876 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDT-IRLEAGVRGKPFPE--VAWTK 11932

Query: 512   EIQEDENDNLFHPKYT----GEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +  +D  D    P+       +    ++   KRS   K+ +TA+NT G    S V   T 
Sbjct: 11933 D--KDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG----SFVAYATV 11986

Query: 568   SP-DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
             +  D+PGP  R L    V+S   +V WDPP+D+GG EI  Y+LE  +  ++   W   YS
Sbjct: 11987 NVLDKPGP-VRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCE--TKRMVWS-TYS 12042

Query: 627   GSATE--YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPRVLGR 682
              +      T T L  G  Y  R    +  G    +ES PV  +T    PG+  PP V  +
Sbjct: 12043 ATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-K 12101

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVY 739
                +E+ + W+ P  + G  ++ Y +E  E      V       PE    V NLLP   Y
Sbjct: 12102 VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEY 12161

Query: 740   RFRVRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
             +FRV+A N+ G G  S  S    A     PPG      +  T    + +GW  P    GA
Sbjct: 12162 QFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGA 12221

Query: 796   DISEYRLE-------------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQ 842
              I  Y +E             W     + +L+       F +  L    +Y  R+ A NQ
Sbjct: 12222 PIIGYVVEMRPKIADASPDEGWKRCNAAAQLV----RKEFTVTSLDENQEYEFRVCAQNQ 12277

Query: 843   AGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
              G G          PA   + +    +LE   +D   D+    LV+        G  I  
Sbjct: 12278 VGIG---------RPAELKEAIKPKEILEPPEIDL--DASMRKLVI-----VRAGCPIRL 12321

Query: 903   YTIDLGDTS-------ITVGNTTMHVMKDL--------LPETTY----RIRIQAINEIGA 943
             + I  G  +       + + N       DL        +P +T     +  +  +N   A
Sbjct: 12322 FAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP--A 12379

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
             G  + F+  +    P     L+ +     S  + W    +   +        + E   K 
Sbjct: 12380 GEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT 12439

Query: 1004  FISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG---PFSETYTFSTTKSVPPTIKA 1059
             + ++      T + V  L     Y FR+ A +E G G      +    S   S P   + 
Sbjct: 12440 WSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRK 12499

Query: 1060  PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE-----YKQVYKGEEATFQISG 1114
               VT++  NS  + W  +P ++         +   RE E     + +    ++ +  ++G
Sbjct: 12500 LEVTEMTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG 12557

Query: 1115  LQTNTDYRFRVCA 1127
             L+    Y+FRV A
Sbjct: 12558 LKEGKKYKFRVAA 12570



 Score =  108 bits (271), Expect = 2e-23
 Identities = 153/654 (23%), Positives = 249/654 (38%), Gaps = 100/654 (15%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGS--QKH 435
            P PP+   +      S  L W AP+DNG S+IT+Y+++  +  R     +    +  +K 
Sbjct: 9193 PSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKR 9252

Query: 436  CKLTKLCPAMGYTFRLAARNDIGTSGY--SQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
              + KL P   Y FR+ A N  G S    S +VV      +P  P  P+++      + +
Sbjct: 9253 YGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLV 9312

Query: 494  QWSKPEGCSPEEVITYTLEIQEDENDNLFH------PKYTGEDLTCTVKNLKRSTQYKFR 547
             W+ P       +  Y LE +E+ +            K   + +   V  L    +Y+FR
Sbjct: 9313 SWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFR 9372

Query: 548  LTASNTEGKSCPSEVLVCTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEI 604
              A N  G   PSE      + D    PGPP+ P VK   T    S+ W PP  +GGS I
Sbjct: 9373 AMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDK-TKSSISLGWKPPAKDGGSPI 9431

Query: 605  LKYLLEITDGNSEANQWEVAYSG----SATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
              Y++E+ +  +    W+         +  E    +LK    Y+ R   ++  G S+ S+
Sbjct: 9432 KGYIVEMQEEGT--TDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSD 9489

Query: 661  S---LPVRTLSIAP-----------------GQCRPPRVL-GRPKHKEVHLEWDVPA-SE 698
            +   +P   +   P                  Q R P V+ GRP  K     W+    ++
Sbjct: 9490 TTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKS---SWEFDGKAK 9546

Query: 699  SGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVS 758
               +   + +    PED   E      +   +         ++ + A N  G    +   
Sbjct: 9547 KAMKDGVHDI----PEDAQLETAENSSV-IIIPECKRSHTGKYSITAKNKAGQKTANCRV 9601

Query: 759  EITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGAD-ISEYRLEWG--EDEESLELIY 815
            ++    GPP   K   +S    G   + W+ PD  G D I  Y +E    + +   ++  
Sbjct: 9602 KVMDVPGPPKDLK---VSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNP 9658

Query: 816  HGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPL 875
                T F + DLL   QY  R++A N+ G GP  E +   T   A DP+           
Sbjct: 9659 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT---ARDPI----------- 9704

Query: 876  DAYPDSPSACLV----------LNWEEPCNNG-SEILAYTIDL--GDTSITVGNT----- 917
              YP  P   L           L+W+ P N+G S +  Y ++    D + T         
Sbjct: 9705 --YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCN 9762

Query: 918  ------TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                      ++DL+    Y  R++A+N  G    S  +       P +PP ++
Sbjct: 9763 KRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 9816



 Score =  103 bits (256), Expect = 1e-21
 Identities = 216/952 (22%), Positives = 362/952 (38%), Gaps = 106/952 (11%)

Query: 280  EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
            +KP V ++ + ++++ W  P   +  P  G       EV  +   R  K  +      L+
Sbjct: 8602 DKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLE-KREVNSTHWSRVNKSLL----NALK 8655

Query: 340  CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVS-FTTHS-CAPECPFPPKLAHRSKSSLTL 397
             N+  L     Y  RV A   +  G  S P    T H   +P  P  P++   S +++ L
Sbjct: 8656 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIEL 8715

Query: 398  QWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPAMGYTFRL 451
            +W+ P  NG  +I  Y ++    K+  G  +    ++K  K+ +     +     Y  R+
Sbjct: 8716 EWEPPAFNGGGEIVGYFVD----KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 8771

Query: 452  AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---VRAGITWV---TLQWSKPEGCSPEE 505
            +A N  G  G   E    T+   PQ P A  L   V+ GI  +   TL+        P  
Sbjct: 8772 SAVNAAG-EGPPGETQPVTVAE-PQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVP 8829

Query: 506  VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
               +T E  E + D +      G      +K+  R    ++ +TA+N    SC S+    
Sbjct: 8830 TKVWTKEEGELDKDRVVIDN-VGTKSELIIKDALRKDHGRYVITATN----SCGSKFAAA 8884

Query: 566  TTSP-DRPGPPTRPLVKGPVTSHGFSV-KWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
                 D PGP     +K  VT+    +  W  P+D+GGSEI  +++E  D  ++ + W  
Sbjct: 8885 RVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKD--AKMHTWRQ 8940

Query: 624  AYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP 683
                  ++   T L  G  YK R    +  G     E  P+  +        P R+    
Sbjct: 8941 PIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTE 9000

Query: 684  KHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGTVY 739
            + K  + L+W  P S  G  +  Y +E    +    E  +    P     V NL    +Y
Sbjct: 9001 RTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMY 9060

Query: 740  RFRVRALND-GGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS 798
             FRV+A+N+ G   P   ++ +      P   K   +S   D  + V    P    AD++
Sbjct: 9061 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLR-LSVRGD-TIKVKAGEPVHIPADVT 9118

Query: 799  EY---RLEWGEDEESL------------ELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                 ++EW ++E  +            E+      T   I   +   +    + A N+ 
Sbjct: 9119 GLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRL 9178

Query: 844  GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILA 902
            G+   +  V        P P   L V + +    Y         L W+ P +N GSEI  
Sbjct: 9179 GSVFRNVHV---EVYDRPSPPRNLAVTDIKAESCY---------LTWDAPLDNGGSEITH 9226

Query: 903  YTIDLGDTS------ITVGNTTM---HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
            Y ID  D S        V NT +   + +  L+P   Y  R++A+N+ G     +  K  
Sbjct: 9227 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVV 9286

Query: 954  TR-----PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
             +     P PP  P++     G  S+ + W        +     +  + E+ +  +  + 
Sbjct: 9287 IQDPYRLPGPPGKPKVLARTKG--SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVS 9344

Query: 1009 RGP-------SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS---VPPTIK 1058
            R P          + V RL E   Y FR  A + AG GP SE             P    
Sbjct: 9345 RAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPS 9404

Query: 1059 APRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEE----ATFQIS 1113
             P V     +S  + W+      G P+  YI+++     +++K+V + ++        + 
Sbjct: 9405 CPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVP 9464

Query: 1114 GLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLD 1165
             L+    YRFRV A     ++    +    P A  + +  EV +  D+G+ D
Sbjct: 9465 NLKELRKYRFRVKAVNEAGESEPSDTTGEIP-ATDIQEEPEVFI--DIGAQD 9513



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 204/939 (21%), Positives = 334/939 (35%), Gaps = 131/939 (13%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEEL------- 338
            ++ A+    +  PP  L+    +       +E   +D GR  +  +I   E L       
Sbjct: 7869 SVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKA 7928

Query: 339  ------ECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH- 389
                  +CN +  D+   T+   +V A   +  G  SEP    +       P PP   H 
Sbjct: 7929 GKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV 7988

Query: 390  --RSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK------ 440
                +  + + WK P  NG S I  Y +E            C  G++K  ++        
Sbjct: 7989 TDAGRKHIAIAWKPPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNSRPIKDL 8037

Query: 441  -------LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT- 492
                   + P   Y  R+ A N IG S  S E+    +   P       L    I  +  
Sbjct: 8038 KFKVEEGVVPDKEYVLRVRAVNAIGVSEPS-EISENVVAKDPDCKPTIDLETHDIIVIEG 8096

Query: 493  --LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              L    P    P   +++  + +E +  +    K         V    R+    + +T 
Sbjct: 8097 EKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITL 8156

Query: 551  SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             N  G +  S  +     P     P + +    +T     + W+PP+ +GG+ IL Y+LE
Sbjct: 8157 ENKLGSATASINVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 8212

Query: 611  ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              +         V    +   +T   L P   Y  R   ++  G  +  E L    ++  
Sbjct: 8213 RREA-GRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE-LKNPVIAQD 8270

Query: 671  PGQCRPPRV---LGRPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGP 724
            P Q   P V   +  P  + + + W  P  + G ++  Y +E     E        +  P
Sbjct: 8271 PKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 8330

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKA------------ 772
             L  T   L  G  Y+FRVRA N  G    S  +  T A  P    K             
Sbjct: 8331 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGD 8390

Query: 773  -------------PCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEE---------S 810
                         P I+   D  V+V  E    +   +   + E  E+E          S
Sbjct: 8391 EIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLS 8450

Query: 811  LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
            ++    G +++  +RD L        ++  N  G             A AP  VS L   
Sbjct: 8451 IDNSKKG-ESQLRVRDSLRPDHGLYMIKVENDHGI------------AKAPCTVSVLDTP 8497

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTS------ITVGNTTMHV-- 921
                   + D     ++  WE P ++ GSEI+ YT++  D +      I V +T  H   
Sbjct: 8498 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY 8557

Query: 922  -MKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPP-LPPRLECAAAGPQSLKLK 977
             +  L+    Y  R++A N  G GP   S+ + AK    PP  P +         S+ +K
Sbjct: 8558 SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVK 8617

Query: 978  WGDSNSKTHAAEDIVYTLQLEDRNKRFIS-IYRGPSHTYK--VQRLTEFTCYSFRIQAAS 1034
            W +   K + +  + Y L+  + N    S + +   +  K  V  L E   Y FR+ A +
Sbjct: 8618 WNE--PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAEN 8675

Query: 1035 EAGEGPFSETYTFSTTKS--VPPTIKAPRVTQLEGNSCEILWETVPSMK--GDPVNYILQ 1090
             AG G FS      T      PP    PRVT     + E+ WE  P+    G+ V Y + 
Sbjct: 8676 AAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEP-PAFNGGGEIVGYFVD 8734

Query: 1091 VLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              +   +E+ +  +   +   + +  ++   DY+ RV A
Sbjct: 8735 KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA 8773



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 90/306 (29%), Positives = 137/306 (44%), Gaps = 22/306 (7%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +  +IQ R+V +SW PP         G +    Y +   +  +   Y I          +
Sbjct: 23931 EYDDIQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLVV 23984

Query: 343   KDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPF-PPKLAHRSKSSLTLQ 398
             K L+   +YH RV A      S      EPV+  T    PE P  PP++   +KSS++L 
Sbjct: 23985 KGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLS 24044

Query: 399   WKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W  P D+G S++T Y +E  E   +   R      +     +T L P   Y FR+ A+ND
Sbjct: 24045 WSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQND 24104

Query: 457   IG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             +G   TS  S+ VVC    + P  P    ++      VTLQW KPE    +E++ Y +E 
Sbjct: 24105 VGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEY 24164

Query: 514   QEDENDNLFHP--KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC----TT 567
             ++   D+ +    K   +D   T+  L  +T+Y+FR+ A N  G S P    +      T
Sbjct: 24165 RQS-GDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLT 24223

Query: 568   SPDRPG 573
             S + PG
Sbjct: 24224 SGEAPG 24229



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 188/836 (22%), Positives = 298/836 (35%), Gaps = 141/836 (16%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPIDN-GSKITNYLLE--------WDEGKRNSGFRQ 427
             + P PPK   ++  ++ S  L WK P D+ G +I  Y++E        W +   + G   
Sbjct: 9605  DVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG--- 9661

Query: 428   CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-VRA 486
                       +  L     Y FR+ A N  G  G   E +  T    P  P  P + ++ 
Sbjct: 9662  -----STTFVVPDLLSEQQYFFRVRAENRFGI-GPPVETIQRTTARDPIYPPDPPIKLKI 9715

Query: 487   GI---TWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP------KYTGEDLTCTVKN 537
             G+     V L W  P+      V  Y +E    +             K   E+L  TV++
Sbjct: 9716  GLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 9775

Query: 538   LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVK----- 592
             L    +Y+FR+ A N  G S PS  +          PP+  L +      G +V      
Sbjct: 9776  LVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKI 9835

Query: 593   ---------W--DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGT 641
                      W   PPK     E + Y       ++  N+  V  + +           G 
Sbjct: 9836  KGVPFPTLTWFKAPPKKPDNKEPVLY-------DTHVNKLVVDDTCTLVIPQSRRSDTG- 9887

Query: 642   LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
             LY + A           S+ + +  L   PG    P         ++ L W  P  + G 
Sbjct: 9888  LYTITA----VNNLGTASKEMRLNVLG-RPGPPVGPIKFESVSADQMTLSWFPPKDDGGS 9942

Query: 702   EVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             +++ Y +E  E              EC  T+  LL G  Y FR+ A N  G G   D SE
Sbjct: 9943  KITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLD-SE 10001

Query: 760   ITTAA---GPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE--------- 806
               TA      PG    P +S      + V WE P+   G+ ++ Y LE  +         
Sbjct: 10002 PETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 10061

Query: 807   DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
             + + ++ +  G    +++  L+  + Y  R+ A N AG GP S   L   PA+A DP++ 
Sbjct: 10062 NRDPIKAMTLGVS--YKVTGLIEGSDYQFRVYAINAAGVGPAS---LPSDPATARDPIAP 10116

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTIDL---GDTSITVGNT----- 917
                    P     D   +   L W  P  + GS++  Y ++    G      G       
Sbjct: 10117 ----PGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 10172

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTRPLPPLPP------------ 962
             T  V+  L     Y+ R++A+N  G    G  +  I+ K R + P               
Sbjct: 10173 TKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVH 10232

Query: 963   -----RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKV 1017
                  R+    +G     + W + N +T   E  + T  +              S   K 
Sbjct: 10233 AGGVIRIIAYVSGKPPPTVTW-NMNERTLPQEATIETTAISS------------SMVIKN 10279

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVT-QLEGNSCEILWET 1076
              + +    YS  + A +EAGE    +         VP  +  P +   L   SC++ W +
Sbjct: 10280 CQRSHQGVYS--LLAKNEAGE---RKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 10334

Query: 1077  VPSMKGDPV-NYILQVLVGRESEYKQ----VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  G P+ NY+++    RES+ +      Y        + GL     Y FR+ A
Sbjct: 10335 PEDDGGSPITNYVIE---KRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAA 10387



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 217/939 (23%), Positives = 341/939 (36%), Gaps = 118/939 (12%)

Query: 271  RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
            +V D+   +   +V+      V L+W  P+        G S    Y V   D  R     
Sbjct: 6780 KVIDVPGPVRNLEVTETFDGEVSLAWEEPLT------DGGSKIIGYVVERRDIKRKTWVL 6833

Query: 331  IIYSGEELECNLKDLRPA-TDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPK 386
                 E  E  +  L+    +Y  RV A      G   E   PV   +    P  P    
Sbjct: 6834 ATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVT 6893

Query: 387  LAHRSKSSLTLQWKAP-IDNGSKITNYLLEW-DEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
            +   ++  ++L W+ P  D G++ITNY++E  D+                   +T +   
Sbjct: 6894 ITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEG 6953

Query: 445  MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQWSKP--E 499
              Y+FR+ A+N IG    S       + +  + PS P  L  +  T   V L+W  P  +
Sbjct: 6954 QEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKD 7013

Query: 500  GCSPEEVITYTLEIQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
            G SP  ++ Y +E  E+  DN          +LT  V  L++  +Y +R++A N  G S 
Sbjct: 7014 GGSP--ILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSD 7071

Query: 559  PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
            PSE+L   T+ D    PT  L        G  V    P        +  L+  T      
Sbjct: 7072 PSEILGPLTADDAFVEPTMDL---SAFKDGLEVIVPNP--------ITILVPSTGYPRPT 7120

Query: 619  NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQ-----CSESLPVRTLS----- 668
              W     G     T   +K  TL       IS    S            V+T+S     
Sbjct: 7121 ATW---CFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDV 7177

Query: 669  --IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE--PEDVASEVYHGP 724
              IA          G      VHL W+ P  + G  ++ Y VE  E   +     +    
Sbjct: 7178 NVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT 7237

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---ITTAAGPPGQCKAPCISCTPDG 781
            +LE TV +L+ G  Y F+V A N  G G  + V E   ++T A  P   +          
Sbjct: 7238 DLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN 7297

Query: 782  CVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLPAAQ 832
             + + W+ P +  G+ I  Y +E        W    E +       +T+ E+  L     
Sbjct: 7298 SIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPV------AETKMEVTGLEEGKW 7351

Query: 833  YCCRLQAFNQAGAG----PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL 888
            Y  R++A N+ GA     P  E+    T   AP+    + +L    + A         V 
Sbjct: 7352 YAYRVKALNRQGASKPSRPTEEIQAVDT-QEAPEIFLDVKLLAGLTVKAGTKIELPATVT 7410

Query: 889  NWEEPCNNGSEILAYTIDLGDTSITVGN----TTMHVMKDLLPETTYRIRIQAINEIGAG 944
               EP    ++  A  I   D  IT+ N    +T+ ++     +T   I I+A+N  G  
Sbjct: 7411 GKPEPKITWTK--ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRA 7467

Query: 945  PFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDR 1000
                 +    +P P  P   +      +S  L W     D  SK         T  + +R
Sbjct: 7468 TAVVEVNVLDKPGP--PAAFDITDVTNESCLLTWNPPRDDGGSK--------ITNYVVER 7517

Query: 1001 NKRFISIYRGPSHT-----YKVQRLTEFTCYSFRIQAASEAGEG------PFSETYTFST 1049
                  ++   S T     +K  +L     Y FR+ A +  G G      P +  Y F  
Sbjct: 7518 RATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDP 7577

Query: 1050 TKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--GE 1106
                PPT   P  + +  ++  + W       G P+  Y ++ L     ++ +  K   +
Sbjct: 7578 PG--PPTRLEP--SDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVK 7633

Query: 1107 EATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPS 1145
            + T+++ GL     YRFRV A        + L+G   PS
Sbjct: 7634 DTTYRVKGLTNKKKYRFRVLA--------ENLAGPGKPS 7664



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 195/897 (21%), Positives = 325/897 (36%), Gaps = 83/897 (9%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC--NLK 343
            +I+  +V+  W PP+        G S   +Y +   DK +     I+ +     C  ++ 
Sbjct: 8507 DIRKTSVLCKWEPPLD------DGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVT 8560

Query: 344  DLRPATDYHVRVYAMYNSVKGS--CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L    +Y  RV A      G    S+P+        P+ P  P +   + +S+ ++W  
Sbjct: 8561 KLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNE 8620

Query: 402  PIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
            P DNGS I  Y LE  E      S   +    + K   +  L   + Y FR+ A N  G 
Sbjct: 8621 PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALK-ANVDGLLEGLTYVFRVCAENAAGP 8679

Query: 460  SGYSQEVVCYTLGN--IPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ-ED 516
              +S      T  +   P  P  PR+     T + L+W  P      E++ Y ++ Q   
Sbjct: 8680 GKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVG 8739

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             N+     +   +    TVK ++    YK R++A N  G+  P E    T +  +  PP 
Sbjct: 8740 TNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQE-PPA 8798

Query: 577  RPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
              L   VKG +          P    G     K   +  +G  + ++  +   G+ +E  
Sbjct: 8799 VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTK-EEGELDKDRVVIDNVGTKSEL- 8856

Query: 634  FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQC--RPPRVLGRPKHKEVH 689
               +    L K     + T  +S C        + +   PG      P V  R   K   
Sbjct: 8857 ---IIKDALRKDHGRYVITATNS-CGSKFAAARVEVFDVPGPVLDLKPVVTNR---KMCL 8909

Query: 690  LEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP----ELECTVGNLLPGTVYRFRVRA 745
            L W  P  + G E++ + +E    +D     +  P      +C +  LL G  Y+FRV A
Sbjct: 8910 LNWSDPEDDGGSEITGFIIER---KDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIA 8966

Query: 746  LNDGGYGPYSDVSEITTA--AGPPGQCKAPCISCTPDGCVLVGWESPDSS-GADISEYRL 802
             N  G GP  ++  I      GPP   +    +      + + W+ P S+ G+ I  Y +
Sbjct: 8967 KNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYII 9026

Query: 803  E-WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPA 858
            E    D+   E +       T F + +L     Y  R++A N+ G + P   L +     
Sbjct: 9027 EKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDD 9086

Query: 859  SAPDPV--------STLCVLEEEPLDAYPDSPSACL-VLNW---EEPCNNGSEILAYTID 906
              P  +         T+ V   EP+    D     +  + W   E      ++ L  T +
Sbjct: 9087 EVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKE 9146

Query: 907  LGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLEC 966
              + S +   T + + K  + E      + A N +G+   +  ++   RP P  P  L  
Sbjct: 9147 --EVSRSEAKTELSIPK-AVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSP--PRNLAV 9201

Query: 967  AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFIS----IYRGPSHTYKVQRLTE 1022
                 +S  L W D+      +E   Y +   D +++               Y + +L  
Sbjct: 9202 TDIKAESCYLTW-DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9260

Query: 1023 FTCYSFRIQAASEAG--EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
               Y FR++A ++ G  +   S+         +P     P+V      S  + W      
Sbjct: 9261 NGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDN 9320

Query: 1081 KGDPV-NYILQ---------VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
             G P+  Y L+           V R    K   KG E  F +  L     Y+FR  A
Sbjct: 9321 GGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVE--FNVPRLLEGVKYQFRAMA 9375



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 143/644 (22%), Positives = 251/644 (38%), Gaps = 65/644 (10%)

Query: 527  TGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
            T E  +  +   K+  + ++++   N  GK+   E  +     D PGP  R L       
Sbjct: 6743 TAEQTSFRILEAKKGDKGRYKIVLQNKHGKA---EGFINLKVIDVPGP-VRNLEVTETFD 6798

Query: 587  HGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHL-KPGTLYK 644
               S+ W+ P  +GGS+I+ Y++E  D   +   W +A     + E+T T L K G  Y 
Sbjct: 6799 GEVSLAWEEPLTDGGSKIIGYVVERRD--IKRKTWVLATDRAESCEFTVTGLQKGGVEYL 6856

Query: 645  LRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPR--VLGRPKHKEVHLEWDVPASES 699
             R      + TG   +    +  R+    PG   PP    +       V L W+ P  + 
Sbjct: 6857 FRVSARNRVGTGEPVETDNPVEARSKYDVPG---PPLNVTITDVNRFGVSLTWEPPEYDG 6913

Query: 700  GCEVSEYSVEMTEPEDV---ASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSD 756
            G E++ Y +E+ +   +    +      +L  TV +++ G  Y FRVRA N  G G  S 
Sbjct: 6914 GAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSA 6973

Query: 757  VSEITTAAGPPGQCKAPCISCTPD---GCVLVGWESP-DSSGADISEY---RLEWGEDEE 809
             +     A P  +   P    + D     V + WE P    G+ I  Y   R E G+D  
Sbjct: 6974 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 7033

Query: 810  ---SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASA-PDPVS 865
               +++L+    +  +++  L    +Y  R+ A N+AG    SE++   T   A  +P  
Sbjct: 7034 IRCNMKLV---PELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTM 7090

Query: 866  TLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDL 925
             L    ++ L+    +P   LV +   P    +    +   + +T   V   T+    +L
Sbjct: 7091 DLSAF-KDGLEVIVPNPITILVPSTGYP--RPTATWCFGDKVLETGDRVKMKTLSAYAEL 7147

Query: 926  L-------PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW 978
            +        +  Y ++++   +  +G     + A+    P  P  L+       S+ L W
Sbjct: 7148 VISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR----PSAPKELKFGDITKDSVHLTW 7203

Query: 979  ------GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
                  G S    +  E    + +   +   F++        + V  L +   Y F++ A
Sbjct: 7204 EPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT-----DLEFTVPDLVQGKEYLFKVCA 7258

Query: 1033 ASEAGEGP---FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
             ++ G G      E    ST  +VP   +  +      NS  + W+   +  G  +   +
Sbjct: 7259 RNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYI 7318

Query: 1090 QVLVGRESEYKQVYKGE---EATFQISGLQTNTDYRFRVCACRR 1130
                 R S+ K V  GE   E   +++GL+    Y +RV A  R
Sbjct: 7319 VERCPRGSD-KWVACGEPVAETKMEVTGLEEGKWYAYRVKALNR 7361



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 66/238 (27%), Positives = 107/238 (44%), Gaps = 17/238 (7%)

Query: 535   VKNLKRSTQY-KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             +KN++R T   K+++  SN  G     + ++     D+P  PT P+V   +  +   + W
Sbjct: 24383 MKNVQRKTHAGKYKVQLSNVFGTV---DAILDVEIQDKPDKPTGPIVIEALLKNSAVISW 24439

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCIST 652
              PP D+GGS I  Y++E  +   E  +W++  S  S T     +L     Y  R    +T
Sbjct: 24440 KPPADDGGSWITNYVVEKCEA-KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNT 24498

Query: 653   GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYS 707
              G    S+ L V ++ I       P   G+P    V      + W  PAS+ G ++  Y 
Sbjct: 24499 FG---ISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYY 24555

Query: 708   VEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 762
             +E  E +    ++       E   +V NL+ G  Y FRV+  N GG   +S++SE  T
Sbjct: 24556 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT 24613



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 171/823 (20%), Positives = 290/823 (35%), Gaps = 78/823 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG--EELE 339
             P+V +    ++ L+W  P+      + G +    Y + + +K  D  Y++  +      E
Sbjct: 23043 PRVVDTTKHSISLAWTKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 23096

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP-KLAHRSKSSLTLQ 398
               + DL+    Y  RV A+  +VKG      S            P  +LA   K ++T++
Sbjct: 23097 FTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIR 23154

Query: 399   WKAPIDNGSKITNY---LLEWDEGKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
               A +     ++     ++ W +   +   R     ++ +  L   K+       + + A
Sbjct: 23155 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 23214

Query: 454   RNDIGTSGYSQEVVCY-TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE 512
              N  G    +  V  Y T G  P +    ++       VT+ W  P       V  Y +E
Sbjct: 23215 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWEIPTIDGGAPVNNYIVE 23270

Query: 513   IQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
              +E                   +  L   T Y FR+   N  G   P E        + P
Sbjct: 23271 KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVP 23330

Query: 573   GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
               P + L    VT    ++ W+ P  +GGS +  Y+LE     +E     V    +  E+
Sbjct: 23331 LVPAK-LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 23389

Query: 633   TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPG---QCRPPRVL----GR 682
             T T L  G  Y  R    +  G S+  E   ++ V+ L + P       P + +    GR
Sbjct: 23390 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGR 23449

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
             P    + +    P + S         ++ E E V  E  H    + T+          + 
Sbjct: 23450 PVELVIPIAGRPPPAASWFFAGS---KLRESERVTVET-HTKVAKLTIRETTIRDTGEYT 23505

Query: 743   VRALNDGGYGPYSDVSEITTAAGPP-GQCKAPCISCTPDGCVLVGWESPD-SSGADISEY 800
             +   N  G    +    I    GPP G  K   I  T    + + WE P+   GA +S Y
Sbjct: 23506 LELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDAT---SITISWEPPELDGGAPLSGY 23562

Query: 801   RLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY--SELVLCQT 856
              +E  +      L +    T + F+   L    +Y  R+ A N+ G G Y  SE++ C++
Sbjct: 23563 VVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS 23622

Query: 857   PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID----LGDTS 911
                 P P  TL +          D     + L W  P  + GS++  Y ++      D  
Sbjct: 23623 SIRIPGPPETLQIF---------DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23673

Query: 912   ITVGNT----TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR------PLPPLP 961
             + V       T +    L     Y  R+ AIN  G+G  S+  K          P  P  
Sbjct: 23674 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQN 23733

Query: 962   PRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLT 1021
             PR+        SL     +    +     ++   +++       +        Y +  L 
Sbjct: 23734 PRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLP 23793

Query: 1022  EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQ 1064
             +   Y FR+ A +  G G  +E         VP T+K   + +
Sbjct: 23794 QGAEYRFRVLACNAGGPGEPAE---------VPGTVKVTEMLE 23827



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 195/894 (21%), Positives = 321/894 (35%), Gaps = 81/894 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+V ++   +V LSW+ P        +G       E +     R  K +I  +       
Sbjct: 24031 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERK-ETSTDKWVRHNKTQITTT----MYT 24085

Query: 342   LKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  L P  +Y  R+ A  +   S     SEPV        P  P   ++   SK S+TLQ
Sbjct: 24086 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 24145

Query: 399   WKAP-IDNGSKITNYLLEW----DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
             W+ P  D G +I  Y +E+    D   + S   +      K   +  L  A  Y FR+ A
Sbjct: 24146 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFA 24202

Query: 454   RNDIGTSGYSQEVVCY----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
              N+ G S   +  +      T G  P +    + V   +        +  G    ++  Y
Sbjct: 24203 ENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWY 24262

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
                 +E      +     G   T TV   ++  +  +   A+N  G+   S  L+   +P
Sbjct: 24263 RFG-KELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP 24321

Query: 570   D-RPGPPTRPLVKGPVTS----HGFSVKWDPPKDNG--GSEILKYLLEITDGNSEANQWE 622
                PG P +    G V S    H   +    P      G ++L+    IT  N+E     
Sbjct: 24322 QFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEH---- 24377

Query: 623   VAYSGSATEYTFTHLKPGTLY------KLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
                        +THL    +       K +    +  G       + ++     P +   
Sbjct: 24378 -----------YTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD---KPDKPTG 24423

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE---CTVGNL 733
             P V+         + W  PA + G  ++ Y VE  E ++ A        +    C + NL
Sbjct: 24424 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 24483

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISC-TPDGCVLVGWES 789
                  Y FRV A N  G     +VS +     P   PG    P I+  T D CV V W+ 
Sbjct: 24484 TENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCV-VAWKP 24542

Query: 790   PDS-SGADISEYRLEWGEDEESLELIYHGTDTR---FEIRDLLPAAQYCCRLQAFNQAGA 845
             P S  GA I  Y LE  E +++  +     + R   F +++L+   +Y  R++  N  G 
Sbjct: 24543 PASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGE 24602

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEE-EPLDAYPDSPS--ACLVLNWEEPC----NNGS 898
               +SE+    TP S   P+      EE   L+    S +   C V    +P       G 
Sbjct: 24603 SEWSEISEPITPKS-DVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGK 24661

Query: 899   EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP 958
             EI+A  +         G   + ++  +  +     +++A N+ G+   +  ++ +     
Sbjct: 24662 EIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKI 24720

Query: 959   PLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQ----LEDRNKRFISIYRGPSHT 1014
              LP  LE   A   +L+ +            D V T Q    L D N  +  I      +
Sbjct: 24721 HLPKTLEGMGA-VHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS 24779

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
                    E     F +  A     G   +T        VP   +  +V+ +  +S  + W
Sbjct: 24780 LVFPNGVERKDAGFYVVCAKNR-FGIDQKTVELDVA-DVPDPPRGVKVSDVSRDSVNLTW 24837

Query: 1075  ETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                 S  G  + NYI++        + +V +  E  + +  L   T Y+FRV A
Sbjct: 24838 TEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIA 24891



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 141/629 (22%), Positives = 239/629 (37%), Gaps = 64/629 (10%)

Query: 446   GYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITW--VTLQWSKPEGCSP 503
             G  + L A N  G+  +   V      + P  P  P  V  G+T    +L WS P     
Sbjct: 17388 GGQYILRASNVAGSKSFPVNVKVL---DRPGPPEGPVQV-TGVTSEKCSLTWSPPLQDGG 17443

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTEGKSCPSE 561
              ++  Y +E  + E   L       E +T ++K   L    +Y FR+ A N  G   P E
Sbjct: 17444 SDISHYVVE--KRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLE 17501

Query: 562   VL-VCTTSPD-RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
                V   +P   PGPP + L    +     +V W+ P  +GGSEI+ Y++E  D +    
Sbjct: 17502 SAPVLMKNPFVLPGPP-KSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI-- 17558

Query: 620   QWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLPVRTLS---IAPGQC 674
             +W        T+     T L     Y+ R    +  G  + S +            PG  
Sbjct: 17559 RWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPP 17618

Query: 675   RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPE-LECT---V 730
                 ++   K+  + L W  P  + G E+  Y VE+ + ++   ++      L  T   +
Sbjct: 17619 TNAHIVDTTKNS-ITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEI 17677

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD---GCVLVGW 787
               L     Y+ RV ALN  G G   + + +     P  + +AP +    +   G V+   
Sbjct: 17678 SKLTEHQEYKIRVCALNKVGLG---EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAG 17734

Query: 788   ESP----DSSGADISE--YRLEWGE--DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA 839
              S        G    E  +  E GE  D+  +E   + T    +  D   A +Y  +L+ 
Sbjct: 17735 GSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLEN 17794

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGS 898
                  +G  S  V  +     P P   L V E     A+         L WE P  + G+
Sbjct: 17795 ----SSGSKSAFVTVKV-LDTPGPPQNLAVKEVRKDSAF---------LVWEPPIIDGGA 17840

Query: 899   EILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIK 951
             ++  Y ID  +++        +  + T   +++L     Y  R+ A NE G G   + + 
Sbjct: 17841 KVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVD 17900

Query: 952   AKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR-NKRFISIYR 1009
             A     PP PP ++        S  L W +       +  + Y ++++ +  +++  +  
Sbjct: 17901 AVKAAEPPSPPGKVTLTDVSQTSASLMW-EKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE 17959

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGE 1038
                    V  L+    Y FR++A +E G+
Sbjct: 17960 SKVCNAVVTGLSSGQEYQFRVKAYNEKGK 17988



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 38/292 (13%)

Query: 888  LNWEEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKDLLPE------------TTYRIR 934
            L WEEP  +G S+I+ Y ++  D    +   T  +  D                  Y  R
Sbjct: 6803 LAWEEPLTDGGSKIIGYVVERRD----IKRKTWVLATDRAESCEFTVTGLQKGGVEYLFR 6858

Query: 935  IQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAED 990
            + A N +G G   +    ++A+++   P PP  +         + L W +       AE 
Sbjct: 6859 VSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTW-EPPEYDGGAEI 6917

Query: 991  IVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG------PF 1041
              Y ++L D+           R    +  V  + E   YSFR++A +  G G      PF
Sbjct: 6918 TNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPF 6977

Query: 1042 SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLV-GRESEY 1099
             +        S P  + +   TQ   +S ++ WE      G P+  YI++    G+++  
Sbjct: 6978 VKVADPIERPSPPVNLTSSDQTQ---SSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWI 7034

Query: 1100 KQVYK-GEEATFQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFV 1149
            +   K   E T++++GL+    Y +RV A  +  +    E+ G  +   AFV
Sbjct: 7035 RCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFV 7086



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 28/75 (37%), Positives = 36/75 (48%), Gaps = 1/75 (1%)

Query: 688   VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V+L W  PAS+ G +++ Y VE      +    V    E   TV NL   T Y+FRV A 
Sbjct: 24833 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24892

Query: 747   NDGGYGPYSDVSEIT 761
             N  G    S+ SE T
Sbjct: 24893 NKFGLSKPSEPSEPT 24907



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 3/91 (3%)

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             D P PP R +    V+    ++ W  P  +GGS+I  Y++E     + A +W        
Sbjct: 24815 DVPDPP-RGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE--KCATTAERWLRVGQARE 24871

Query: 630   TEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             T YT  +L   T Y+ R    +  G S+ SE
Sbjct: 24872 TRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24902



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 379   PECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P+ P   K++  S+ S+ L W  P  D GSKITNY++   E    +  R    G  +  +
Sbjct: 24817 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIV---EKCATTAERWLRVGQARETR 24873

Query: 438   LT--KLCPAMGYTFRLAARNDIGTSGYSQ 464
              T   L     Y FR+ A N  G S  S+
Sbjct: 24874 YTVINLFGKTSYQFRVIAENKFGLSKPSE 24902



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 1/101 (0%)

Query: 461   GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
             G  Q+ V   + ++P  P   ++       V L W++P      ++  Y +E      + 
Sbjct: 24803 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24862

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
                     E    TV NL   T Y+FR+ A N  G S PSE
Sbjct: 24863 WLRVGQARET-RYTVINLFGKTSYQFRVIAENKFGLSKPSE 24902


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  162 bits (410), Expect = 2e-39
 Identities = 201/810 (24%), Positives = 324/810 (40%), Gaps = 96/810 (11%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
            P PP    +   +  S  L W  P D+G SKITNY++E          +        + K
Sbjct: 7412 PGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 7471

Query: 438  LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQ 494
             TKL P   Y FR+AA N  G  G   +    T       P  P RL  + IT   VTL 
Sbjct: 7472 ATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLT 7530

Query: 495  WSKPEGCSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
            W +P+      +  Y +E  + + D      K   +D T  VK L    +Y+FR+ A N 
Sbjct: 7531 WCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENL 7590

Query: 554  EGKSCPS---EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             G   PS   E ++     D P PP +P VK  V      + W  P+ +GG++I  Y++E
Sbjct: 7591 AGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIESYVIE 7649

Query: 611  ITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPV--RT 666
            +    ++  +W  VA     T++    L  G  Y  R   ++  G S+ SE S PV  R 
Sbjct: 7650 MLKTGTD--EWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCRE 7707

Query: 667  LSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP-- 724
                P   R   V+   K+    L+W VP  + G  ++ Y VE  +      +       
Sbjct: 7708 KLYPPSPPRWLEVINITKNT-ADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVK 7766

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDG 781
            + +CTV  L  G++Y FRV A N  G   Y+++ +   A      PG   A  +      
Sbjct: 7767 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKR 7826

Query: 782  CVLVGWESPDSSGA-DISEYRLEWGEDEESLELIY------HGTDTRFEIRDLLPAAQYC 834
             V + WE P + G   I  Y +E    +E L   +       G D  F + D++   +  
Sbjct: 7827 HVDLKWEPPKNDGGRPIQRYVIE---KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQ 7883

Query: 835  CRLQAFNQAGAGPYSE---LVLCQTPASAPDPVSTLCVLEEEPLDAY-PDSPSACLVLNW 890
             +++A N+AG G  SE   ++  + P S P P          PLD +  D+    + + W
Sbjct: 7884 FQVRAENEAGVGHPSEPTEILSIEDPTSPPSP----------PLDLHVTDAGRKHIAIAW 7933

Query: 891  EEP-CNNGSEILAYTIDLGDT---------SITVGNTTMHVMKDLLPETTYRIRIQAINE 940
            + P  N GS I+ Y +++            S  + +    V + ++P+  Y +R++A+N 
Sbjct: 7934 KPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNA 7993

Query: 941  IGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH-----AAEDIVYTL 995
            IG    S+  +      P   P ++                  +TH       E +   +
Sbjct: 7994 IGVSEPSEISENVVAKDPDCKPTIDL-----------------ETHDIIVIEGEKLSIPV 8036

Query: 996  QLEDRNKRFISIYRGPSHTYKVQRLT---EFTCYSFRIQAASEAGEGPFS---ETYTFST 1049
                     +S ++         RLT   +       +  +  A  G ++   E    S 
Sbjct: 8037 PFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 8096

Query: 1050 TKSV-------PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQ 1101
            T S+       P   K  + + +  +SC++ WE      G P+ +Y+L+        Y  
Sbjct: 8097 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8156

Query: 1102 VYKGE-EATFQISGLQTNTDYRFRVCACRR 1130
            V  GE + ++ +  L  N +Y FRV A  +
Sbjct: 8157 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8186



 Score =  157 bits (396), Expect = 8e-38
 Identities = 220/917 (23%), Positives = 369/917 (40%), Gaps = 77/917 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D     +  +V  +   +V L+W PP+        G S   +Y V   +  R     
Sbjct: 15575 RVLDTPGPPQDLKVKEVTKTSVTLTWDPPL------LDGGSKIKNYIVEKRESTRKAYST 15628

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             +  +  +    +  L+    Y+ RV A      G  +E       S  P  P    L   
Sbjct: 15629 VATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDV 15688

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W+ P  D GS+I  Y++E  + K +  +  C         +T L     Y+F
Sbjct: 15689 TRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSF 15747

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT---LQWSKPEGCSPEEV 506
             R++A+N+ G S   Q  V     ++  +P A +L+    T +    L+   P    P   
Sbjct: 15748 RVSAQNEKGISDPRQLSVPVIAKDLV-IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPA 15806

Query: 507   ITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT 566
             +T+  +    +     + + T  +   T+K+  R     + +  +N+ G++  +  ++  
Sbjct: 15807 VTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVL 15866

Query: 567   TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
                D+PGPPT P+    VT+   ++ W PPK +GGS I  Y++E  D  +    W++  +
Sbjct: 15867 ---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRD--TSTTTWQIVSA 15921

Query: 627   GSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP-- 683
               A T      LK G  Y+ R    +  G S    S P    ++A    + P   G P  
Sbjct: 15922 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEP----TVAQYPFKVPGPPGTPVV 15977

Query: 684   ---KHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGT 737
                    + ++W+ P S+ G  V  Y +E  E   +     +    P+ +     L  G 
Sbjct: 15978 TLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGV 16037

Query: 738   VYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SS 793
              Y FRV A N  G G  S VSE   A     PPG+ +A  ++      V + W+ P    
Sbjct: 16038 EYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVT---RNSVTLQWKKPTYDG 16094

Query: 794   GADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRLQAFNQAG------ 844
             G+ I+ Y +E  E  E   +    T   DT FE+  L+   +Y  R+ A N AG      
Sbjct: 16095 GSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPS 16154

Query: 845   --AGPYSELVLCQTPASAPDP--VSTLCVLEEEPL----DAYPDSPSACLVLNWEEPCNN 896
                G  +       P  + DP    T+ V   E      D Y         +  ++  +N
Sbjct: 16155 ESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN 16214

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
              + +   + D   TS++V        KD +   +    ++A N  G    +  +K   RP
Sbjct: 16215 TARLEIKSTDFA-TSLSV--------KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 16265

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY- 1015
              PP  P +  +    +   L W     +   ++ I Y ++  + ++   ++      T  
Sbjct: 16266 GPPEGP-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLS 16323

Query: 1016  -KVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
              KV +L E   Y+FRI A ++ G G    SE         VP   KAP VT +  +S  +
Sbjct: 16324 CKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIV 16383

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACR 1129
             +WE   S  G  +  Y+L+        + + +K    E   +++GL  N DY FRV A  
Sbjct: 16384 VWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA-- 16441

Query: 1130  RCLDTSQELSGAFSPSA 1146
                + +  LS    PSA
Sbjct: 16442 ---ENAAGLSEPSPPSA 16455



 Score =  156 bits (395), Expect = 1e-37
 Identities = 223/898 (24%), Positives = 352/898 (39%), Gaps = 90/898 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS++ A + VLSW  P         G +   +Y V   + G      +  S +  +  +
Sbjct: 22377 EVSSVSAESCVLSWGEP------KDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKV 22430

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L    +Y  RV +   +   K   S P+        P  P  P++ H S ++++++W+
Sbjct: 22431 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22490

Query: 401   API-DNGSKITNYLLEWDEGKRNSGFRQ----CFFGSQKHCKLTKLCPAMGYTFRLAARN 455
              P  D GSKI  Y +E  E       ++    C    + + K+T L   + Y FR  A N
Sbjct: 22491 EPYHDGGSKIIGYWVEKKERNTILWVKENKVPCL---ECNYKVTGLVEGLEYQFRTYALN 22547

Query: 456   DIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE--- 512
               G S  S+        N    P  P +     + V+L WS P      +V+ Y +E   
Sbjct: 22548 AAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKP 22607

Query: 513   IQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPSEVLVCTTSPD 570
             + E  +       YT   D   TV  L     Y+FR+ A N  G  S  SE     T  D
Sbjct: 22608 VSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRD 22667

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKD------NGGSEILKYLLEITDGNSEANQWE-- 622
                PP   L       HG  V      D       GG    K +   T G+ E +  E  
Sbjct: 22668 EYAPPKAEL---DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIW--TKGDKELDLCEKV 22722

Query: 623   -VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
              + Y+G                K      +  G    + S+ V+ L  +PG C    V  
Sbjct: 22723 SLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTK--AVSVMVKVLD-SPGPCGKLTV-S 22778

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG--PELECTVGNLLPGTVY 739
             R   ++  L W +P  + G E++ Y VE  E   +   +  G  P L   V  L+    Y
Sbjct: 22779 RVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22838

Query: 740   RFRVRALNDGGYGPYSDVSEIT-----TAAGPPGQCKAPCISCTPDGCVLVGWESPDSSG 794
              FRVRA+N  G G   +   I      T   PPG    P    T    +++ W  P+S G
Sbjct: 22839 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG---IPEEVGTGKEHIIIQWTKPESDG 22895

Query: 795   A-DISEYRLEWGEDEE----SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
               +IS Y ++  E +      +   Y   DTR ++  L+    Y  R+ A N AG    S
Sbjct: 22896 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22955

Query: 850   E---LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTI 905
             E    + C+ P+  P P S   V+         D+    + L W +P  + G++I+ Y +
Sbjct: 22956 EASNFISCREPSYTPGPPSAPRVV---------DTTKHSISLAWTKPMYDGGTDIVGYVL 23006

Query: 906   DLGD----------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR 955
             ++ +          T+ T+ NT   V  DL     Y  R+ A+N  G   +S+ I A+  
Sbjct: 23007 EMQEKDTDQWYRVHTNATIRNTEFTV-PDLKMGQKYSFRVAAVNVKGMSEYSESI-AEIE 23064

Query: 956   PLPPLP-PRLECAAAGPQSLKLKWGDS-----NSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
             P+  +  P LE A    +++ ++ G S     +        I ++ Q  D   R I    
Sbjct: 23065 PVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTT 23124

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                    V ++  +    + I+A +++G+   +       T    P++K   V++   +S
Sbjct: 23125 ESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR---DS 23181

Query: 1070  CEILWETVPSMKGDPV-NYILQVLVGRESEYKQV-YKGEEATFQISGLQTNTDYRFRV 1125
               I WE      G PV NYI++        +K V  K  +  ++ISGL   T Y FRV
Sbjct: 23182 VTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23239



 Score =  151 bits (382), Expect = 3e-36
 Identities = 213/899 (23%), Positives = 335/899 (37%), Gaps = 85/899 (9%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE--- 337
             +P+V ++ A A+ + W  P       H G S    Y V   ++       I++  E    
Sbjct: 22474 RPEVYHVSANAMSIRWEEPY------HDGGSKIIGYWVEKKERNT-----ILWVKENKVP 22522

Query: 338   -LECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSS 394
              LECN K   L    +Y  R YA+  +     SE           + P  P++   ++S+
Sbjct: 22523 CLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST 22582

Query: 395   LTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFR--QCFFG--SQKHCKLTKLCPAMGYTF 449
             ++L W AP  D GSK+  Y++E          R  +C +   S     +T L     Y F
Sbjct: 22583 VSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEF 22642

Query: 450   RLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPRL------VRAGITWVTLQWSKPE 499
             R+ A+N  G      E    V C      P+     RL      +RAG   V        
Sbjct: 22643 RVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVL---DAAV 22699

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             G  PE  I +T   +E +       +YTG+  T  +K   RS   K+ LT  N  G    
Sbjct: 22700 GGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAV 22759

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
             S ++    SP     P   L    VT    ++ W  P+++GG+EI  Y++E  +  S  N
Sbjct: 22760 SVMVKVLDSPG----PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRE-TSRLN 22814

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPP 677
                V        Y  T L     Y  R   ++  G     ES P+  R     P     P
Sbjct: 22815 WVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIP 22874

Query: 678   RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTVGNL 733
               +G  K + + ++W  P S+ G E+S Y V+  E + +     ++ Y   +    V +L
Sbjct: 22875 EEVGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSL 22933

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESP 790
             + G  Y+FRV A+N  G    S+ S   +   P   PG   AP +  T    + + W  P
Sbjct: 22934 MEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKP 22993

Query: 791   -DSSGADISEYRLEWGEDEESLELIYHGT----DTRFEIRDLLPAAQYCCRLQAFNQAGA 845
                 G DI  Y LE  E +       H      +T F + DL    +Y  R+ A N  G 
Sbjct: 22994 MYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGM 23053

Query: 846   GPYSELVLCQTPAS---------APDPVSTLCVLEEEPLDAYPD-SPSACLVLNWEEPCN 895
               YSE +    P           A D   T+ +     L      S     V+ W +   
Sbjct: 23054 SEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSK--- 23110

Query: 896   NGSEILAYTIDLGDTSI--TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                      IDL   +I  T  + ++ ++  +      +  I+A N+ G    +  +K  
Sbjct: 23111 -------QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVY 23163

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH 1013
               P P   P ++       S+ + W        A  +     + E   + F ++    S 
Sbjct: 23164 DTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK 23221

Query: 1014  T-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T Y++  L E T Y FR+   +  G G   ET        VP       V  +  ++  +
Sbjct: 23222 TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTL 23281

Query: 1073  LWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQ--ISGLQTNTDYRFRVCA 1127
              WE  P   G      Y+L+        + +V   +    +  ++ L     Y FR+ A
Sbjct: 23282 AWEK-PLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 23339



 Score =  151 bits (381), Expect = 4e-36
 Identities = 204/888 (22%), Positives = 355/888 (39%), Gaps = 68/888 (7%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P V+N+   ++ + W  PV       +G S    Y + + D+         K++      
Sbjct: 20304 PWVTNVTRESITVGWHEPVS------NGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHF 20357

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  +  +     Y  RVYA   +  G  S P        A E P   ++   SK+S++L 
Sbjct: 20358 K--VTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLS 20415

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W+ P  D GSKIT Y++E  +       +  F   ++    ++ L     Y FR+ ARN 
Sbjct: 20416 WQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNA 20475

Query: 457   IGTSGYSQEVV----CYTL--GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYT 510
             +G+     EVV    C     G +  +P     V       +++        P   I + 
Sbjct: 20476 VGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 20535

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
              + +E + + L   + T +  +  +K+  R     + L   N  G +  +   +     D
Sbjct: 20536 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT---IRVQILD 20592

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
             +PGPP  P+    VT+   ++ W PP D+GG++I  Y++E  +  S      V+      
Sbjct: 20593 KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRE-TSRVVWSMVSEHLEEC 20651

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQC--SESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
               T T +  G  Y  R   ++  G  +   S+S+  +   + PG    P V    K+  +
Sbjct: 20652 IITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKN-SM 20710

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPGTVYRFRV 743
              + W  P ++ G ++S Y +E  + +      V  E       + T   L   + Y++RV
Sbjct: 20711 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVT--GLTENSDYQYRV 20768

Query: 744   RALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISE 799
              A+N  G GP+S+ SE   AA    PPG      I+ +    + +GW  P    G+ ++ 
Sbjct: 20769 CAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTG 20828

Query: 800   YRLE--WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAGAG---PYSELV 852
             Y +E   GE+EE   +   G    T + + +L P   Y  R+ A N AG G     +E V
Sbjct: 20829 YVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPV 20888

Query: 853   LCQTPASAPD-------PVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
               +    AP+         S +    E+     P        + W +   N      Y+I
Sbjct: 20889 QAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSI 20948

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             +  D+S      ++  +  +    T +  +   N +G  P S  +  K    P    +L+
Sbjct: 20949 ENTDSS------SLLTIPQVTRNDTGKYILTIENGVGE-PKSSTVSVKVLDTPAACQKLQ 21001

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI--YRGPSHTYKVQRLTEF 1023
                    ++ L W D       +  I Y ++  D  KR  S+  ++  S ++K+  L+E 
Sbjct: 21002 VKHVSRGTVTLLW-DPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21060

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             T + FR+ A +E G G   ET        VP  I+   +      S  + W T P   G 
Sbjct: 21061 TPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW-TKPDFDGG 21119

Query: 1084  PVNYILQVLVGRESEYKQVYK----GEEATFQISGLQTNTDYRFRVCA 1127
              V  I + +V R+ + +Q +      +    ++S L+  +   FRV A
Sbjct: 21120 SV--ITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFA 21165



 Score =  147 bits (372), Expect = 5e-35
 Identities = 194/806 (24%), Positives = 311/806 (38%), Gaps = 94/806 (11%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++S+TLQWK P  D GSKIT Y++E  E       +  F      
Sbjct: 16067 CDP--PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDT 16124

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPR-----LVR 485
             H ++T L     Y FR+ ARN  G      E    +      + P++   P+     +V 
Sbjct: 16125 HFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH 16184

Query: 486   AGITWV-----------TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG ++            T+QW K +              QE  N      K T    + +
Sbjct: 16185 AGESFKVDADIYGKPIPTIQWIKGD--------------QELSNTARLEIKSTDFATSLS 16230

Query: 535   VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD 594
             VK+  R     + L A N  G+     V V     DRPGPP  P+V   VT+   ++ W 
Sbjct: 16231 VKDAVRVDSGNYILKAKNVAGER---SVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWK 16287

Query: 595   PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT-EYTFTHLKPGTLYKLRACCISTG 653
             PP  +GGS+I+ Y++E  + +     W V  +   T     T L  G  Y  R   ++  
Sbjct: 16288 PPLQDGGSDIINYIVERRETSRLV--WTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKY 16345

Query: 654   GHSQCSESLPV--RTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV  +   + P   + P V    K   + + W+ PAS+ G E+  Y +E  
Sbjct: 16346 GVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI-VVWERPASDGGSEILGYVLEKR 16404

Query: 712   EPEDVASEVYHGP---ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP-- 766
             + E +     H     EL   V  L+    Y FRV A N  G    S  S    A  P  
Sbjct: 16405 DKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 16464

Query: 767   -PGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE---DEESLELIYHGTD-T 820
              PG    P +       V + W  P    G +I  Y +E  +    E ++     G + T
Sbjct: 16465 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 16524

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
               E+  LL   +Y  R+ A N+AG G ++++   ++ +    APD    L + +   + A
Sbjct: 16525 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRA 16584

Query: 878   -------YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT 930
                     P        + W +      +     +    TS+ + N   +          
Sbjct: 16585 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRY------DSGK 16638

Query: 931   YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSK 984
             Y + +    E  +G  S F+  +    P  P  L+       S+ + W      G S  K
Sbjct: 16639 YTLTL----ENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16694

Query: 985   THAAEDIVYTLQLEDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              +  E      + E   K + ++      +++K+ +L E   Y FR+ A +E G G  ++
Sbjct: 16695 NYIVE------KREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 16748

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQ 1101
             T        VP       V  +  NS  + W T P   G    + YI+++      ++ +
Sbjct: 16749 TADPIKVAEVPQPPGKITVDDVTRNSVSLSW-TKPEHDGGSKIIQYIVEMQAKHSEKWSE 16807

Query: 1102  VYKGEEATFQISGLQTNTDYRFRVCA 1127
               + +     I+ L    +Y FRV A
Sbjct: 16808 CARVKSLQAVITNLTQGEEYLFRVVA 16833



 Score =  147 bits (372), Expect = 5e-35
 Identities = 204/794 (25%), Positives = 309/794 (38%), Gaps = 69/794 (8%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++++TL+WK P  D GSKIT Y++E  +       +  F    + 
Sbjct: 18231 CDP--PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLET 18288

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVR 485
                ++ L     Y FR+ ARN  G     S  S  +      + P     P+     +V 
Sbjct: 18289 EFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVH 18348

Query: 486   AGITWVT-----------LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG T+V            + WSK +G   EE     +EI           K T +  T  
Sbjct: 18349 AGETFVLEADIRGKPIPDVVWSK-DGKELEETAA-RMEI-----------KSTIQKTTLV 18395

Query: 535   VKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             VK+  R+   ++ L  SN  G KS P  V V     DRPGPP  PL    VT+    + W
Sbjct: 18396 VKDCIRTDGGQYILKLSNVGGTKSIPITVKVL----DRPGPPEGPLKVTGVTAEKCYLAW 18451

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTG 653
             +PP  +GG+ I  Y++E  +  S  +  +V+    A  Y  T L PG  Y  R   ++  
Sbjct: 18452 NPPLQDGGANISHYIIEKRE-TSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18510

Query: 654   GHSQCSESLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV   +    PG    P V    K   V + W  P  + G E+  Y +E  
Sbjct: 18511 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMV-VTWARPVDDGGTEIEGYILEKR 18569

Query: 712   EPEDVASEVYHG---PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG--- 765
             + E V     +     +L   V  L  G  Y FRV A N  G G  S+ S    A     
Sbjct: 18570 DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALY 18629

Query: 766   PPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGE---DEESLELIYHGTD-T 820
             PPG    P ++ T    V + W  P    GA +  Y +E  E   DE +      G    
Sbjct: 18630 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGK 18689

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
             +F +  L    +Y  R+ A N  G G  + L   V+ Q     P+      + +   L A
Sbjct: 18690 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 18749

Query: 878   YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQA 937
                      +    EP     +      D     +T  + TM V+ ++    + R  +  
Sbjct: 18750 SATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-SSFTMLVIDNVTRFDSGRYNLTL 18808

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQL 997
              N   +G  + F+  +    P  P  L        S+ L W        A        + 
Sbjct: 18809 EN--NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 18866

Query: 998   EDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT 1056
             E   K + +I       T++++ L E   Y FR+ A++E G G  +E  T    K   P 
Sbjct: 18867 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAE--TTEPVKVSEPP 18924

Query: 1057  IKAPRVTQLE--GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQIS 1113
             +   RVT ++   N+  I WE   S  G  +  Y++++      ++    + +     IS
Sbjct: 18925 LPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATIS 18984

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y FRV A
Sbjct: 18985 GLTAGEEYVFRVAA 18998



 Score =  146 bits (368), Expect = 1e-34
 Identities = 220/960 (22%), Positives = 387/960 (40%), Gaps = 137/960 (14%)

Query: 249   RRARSSPKSNDSDLQEYELEVKRVQD------ILSGIEKP------QVSNIQARAVVLSW 296
             R + +   +N +D  +Y L ++ V        ++  ++ P       V ++   + VLSW
Sbjct: 19867 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 19926

Query: 297   APPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVY 356
               P      P        +Y +   +  +     +  +   L   + +L+    Y+ RV 
Sbjct: 19927 DVPENDGGAPVK------NYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVS 19980

Query: 357   AMYN---SVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKI 409
                     +     E V  T      E P PP+   +   SK S++L W  P  D GS+I
Sbjct: 19981 GENEFGVGIPAETKEGVKIT------EKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRI 20034

Query: 410   TNYLLE-WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVC 468
              +Y++E  ++G++N  + +C      H  ++ L     Y FR+ A N  G S   + ++ 
Sbjct: 20035 VHYVVEALEKGQKN--WVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLP 20092

Query: 469   YTLG--------NIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
               +         ++   PS    VRAG     L+   P    P   +T + +    +   
Sbjct: 20093 VLIKEQLEPPEIDMKNFPSHTVYVRAGSN---LKVDIPISGKPLPKVTLSRDGVPLKATM 20149

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLV 580
              F+ + T E+LT  +K    +   ++ +TA+N+ G +   +  +     DRPGPPT P+V
Sbjct: 20150 RFNTEITAENLTINLKESVTADAGRYEITAANSSGTT---KAFINIVVLDRPGPPTGPVV 20206

Query: 581   KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPG 640
                +T    ++KW+PPK +GGS++  Y+L +    S A   EV+ + + T      L  G
Sbjct: 20207 ISDITEESVTLKWEPPKYDGGSQVTNYIL-LKRETSTAVWTEVSATVARTMMKVMKLTTG 20265

Query: 641   TLYKLRACCISTGGHSQCSES--LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
               Y+ R    +  G S   +S  + V+     PG    P V    + + + + W  P S 
Sbjct: 20266 EEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTR-ESITVGWHEPVSN 20324

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDGGYGPYS 755
              G  V  Y +EM +   +  +  +   +  T   V  +  G +Y FRV A N  G G  S
Sbjct: 20325 GGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 20384

Query: 756   DVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEY---RLEWGEDE 808
               SE      A  PP   +   IS      V + W+ P    G+ I+ Y   R +  +  
Sbjct: 20385 HPSEPVLAIDACEPPRNVRITDIS---KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGR 20441

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL- 867
              +     + T+T+F I  L   +QY  R+ A N  G+           P+    P++ + 
Sbjct: 20442 WTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGS--------ISNPSEVVGPITCID 20493

Query: 868   --------CVLEEEPLDAYPDSPSACL----------VLNW----EEPCNNGSEILAYTI 905
                       LE   +  Y    S  L           + W    +E   N    +  T 
Sbjct: 20494 SYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTT 20553

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             DL   SI + +       D L    Y ++++  N +G+   +  ++   +P PP  P +E
Sbjct: 20554 DL--ASILIKDA------DRLNSGCYELKLR--NAMGSASATIRVQILDKPGPPGGP-IE 20602

Query: 966   CAAAGPQSLKLKW----GDSNSK-TH------AAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
                   + + L W     D  +K TH          +V+++  E   +  I+       T
Sbjct: 20603 FKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIIT-------T 20655

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV----PPTIKAPRVTQLEGNSC 1070
              K+ +  E   Y FR++A ++ G G   E+ +     +     PP I  P VT++  NS 
Sbjct: 20656 TKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI--PEVTKITKNSM 20710

Query: 1071  EILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              ++W    +  G  ++ Y L+    +   + +V K    +   +++GL  N+DY++RVCA
Sbjct: 20711 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCA 20770



 Score =  145 bits (366), Expect = 2e-34
 Identities = 219/898 (24%), Positives = 343/898 (38%), Gaps = 89/898 (9%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             + P +SNI    + +SW PP      P +G         A++    + K  I     E  
Sbjct: 13120 DPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-----ERT 13174

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPEC----PFPPKLAHRSKSSL 395
                  L+  T+Y  RV A+  +  G  S+  S   ++  P+     P  PK+   ++SS+
Sbjct: 13175 LKATGLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13233

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG---SQKHCKLTKLCPAMGYTFRL 451
             +L W  P  D GS I  YL+E      ++  R C       +   ++T L     Y FR+
Sbjct: 13234 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR-CNLPQNLQKTRFEVTGLMEDTQYQFRV 13292

Query: 452   AARNDIGTSG--------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
              A N IG S         Y ++++    G +        ++RAG   VT++   P    P
Sbjct: 13293 YAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG---VTMRLYVPVKGRP 13349

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVL 563
                IT++       +      K T  D     +N+ +    K+ LT  N+ GK    E  
Sbjct: 13350 PPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGK---KEYT 13406

Query: 564   VCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE- 622
             +     D PGPP    VK  ++     V W+PP  +GGS I+ Y+++  D  +E   W  
Sbjct: 13407 IVVKVLDTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRD--AERKSWST 13463

Query: 623   VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             V    S T +   +L+ G  Y  R    +  G     E+      S  PG     +V   
Sbjct: 13464 VTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSV 13523

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
              K     + W  P S+ G  +  Y V+    E+    V     L+ +  +L  G  Y FR
Sbjct: 13524 SK-SSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFR 13582

Query: 743   VRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS---E 799
             V A N+ G G     SEIT  A          +   PD C L    S       I     
Sbjct: 13583 VSAENENGEG---TPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPA 13639

Query: 800   YRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPAS 859
               + W + E+ L      TDTR  +     A      +    ++ AG Y+  +  +  A 
Sbjct: 13640 PSVSWKKGEDPL-----ATDTRVSVES--SAVNTTLIVYDCQKSDAGKYT--ITLKNVAG 13690

Query: 860   APDPVSTLCVLEEEPLDAYP----DSPSACLVLNWEEPCNN-GSEILAYTIDLGDT---- 910
               +   ++ V+ +  +   P    +  +  + L W  P ++ GSEI  Y ++  D+    
Sbjct: 13691 TKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNK 13750

Query: 911   ----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG---PFSQFIKAKTRPLPPLPPR 963
                 +  V  TT  V + L     Y  R+ A N+ G G        +      +P  PP 
Sbjct: 13751 WVTCASAVQKTTFRVTR-LHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPP 13809

Query: 964   LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT------YKV 1017
                      S+ L W D   KT  +    Y L+ ++RN     +++  + T      +KV
Sbjct: 13810 PNIVDVRHDSVSLTWTDP-KKTGGSPITGYHLEFKERNS---LLWKRANKTPIRMRDFKV 13865

Query: 1018  QRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWET 1076
               LTE   Y FR+ A + AG G P   +        + P  K P V  +  NS  ++W T
Sbjct: 13866 TGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK-PEVINITRNSVTLIW-T 13923

Query: 1077  VPSMKGDP--VNYILQVLVGRESEYKQVYKGE-----EATFQISGLQTNTDYRFRVCA 1127
              P   G      YI++    R+   K   K       E  F ++ L     Y FR+ A
Sbjct: 13924 EPKYDGGHKLTGYIVE---KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRA 13978



 Score =  145 bits (366), Expect = 2e-34
 Identities = 216/907 (23%), Positives = 353/907 (38%), Gaps = 111/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P+V +     ++++W  PV      + G S    Y +   ++         KI+ +  ++
Sbjct: 19221 PKVVHATKSTMLVTWQVPV------NDGGSRVIGYHLEYKERSSILWSKANKILIADTQM 19274

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCS---EPVSFTTHSCAPECPFPPKLAHRSKSSL 395
             +  +  L     Y  RVYA   +  G CS   EPV      C P  P  P++ + ++ S+
Sbjct: 19275 K--VSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDP--PGQPEVTNITRKSV 19329

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYTFRLAA 453
             +L+W  P  D G+KIT Y++E  E       +  +   Q+ + ++T+L     Y FR+ A
Sbjct: 19330 SLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFA 19389

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGITWVTLQWSKPEGCS 502
             RN   +     E     +      P  PR+           V+AG     L+ +      
Sbjct: 19390 RNAADSVSEPSESTGPIIVKDDVEP--PRVMMDVKFRDVIVVKAG---EVLKINADIAGR 19444

Query: 503   PEEVITYT---LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             P  VI++    +EI+E     +     T      TVK+  R    ++ LT  N  G    
Sbjct: 19445 PLPVISWAKDGIEIEERARTEIIS---TDNHTLLTVKDCIRRDTGQYVLTLKNVAGTR-- 19499

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V V     D+PGPP  PL    +T+   S+ W  P+++GG++I  Y++E  + +  A 
Sbjct: 19500 -SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLA- 19557

Query: 620   QWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
              W +       T    T L  G  Y  R   ++  G  +  ES+ ++ L        P  
Sbjct: 19558 -WTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTS 19616

Query: 679   VLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDV------ASEVYHGPELECTVG 731
             +      KE + L W  P S+ G E+S Y +E  E   +         VY   +L     
Sbjct: 19617 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVY---DLRVKST 19673

Query: 732   NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWE 788
              L  G  Y +RV A N  G    S+ S +  A  P   P     P I  +    + + W 
Sbjct: 19674 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWV 19733

Query: 789   SP-DSSGADISEYRLEW--GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGA 845
              P    GA I+ Y +E+   +D +    I     T + I  L   A+Y  R+++ N+ GA
Sbjct: 19734 KPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 19793

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN---------------- 889
                        P+ + DP       EEEPL          L++                 
Sbjct: 19794 ---------SDPSDSSDP-QIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPV 19843

Query: 890   ----WEEPCNNGSEILAYTIDLGD--TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
                 W +P +      AY +D  D  TS+T+ N   +          Y + IQ  N + A
Sbjct: 19844 PNVLWSKP-DTDLRTRAY-VDTTDSRTSLTIENANRN------DSGKYTLTIQ--NVLSA 19893

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
                +  +K    P P  P  +       +S  L W    +   A     +  + E   K 
Sbjct: 19894 ASLTLVVKVLDTPGP--PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKA 19951

Query: 1004  FISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRV 1062
             ++S+    +  +YKV  L E   Y FR+   +E G G  +ET         P   +   V
Sbjct: 19952 WVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGV 20011

Query: 1063  TQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             T +  +S  + W   P   G    V+Y+++ L   +  + +    +     +SGL+ N++
Sbjct: 20012 TSISKDSVSLTW-LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSE 20070

Query: 1121  YRFRVCA 1127
             Y FRV A
Sbjct: 20071 YFFRVFA 20077



 Score =  145 bits (365), Expect = 3e-34
 Identities = 217/907 (23%), Positives = 339/907 (37%), Gaps = 109/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG------ 335
             P  + I   ++V+ W  PV     P  G    Y  E       R  +  I+++       
Sbjct: 17057 PFATAISKDSMVIQWHEPVNNGGSPVIG----YHLE-------RKERNSILWTKVNKTII 17105

Query: 336   EELECNLKDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
              + +   ++L    +Y  RVYA  +    K S +         C P  P  P+     ++
Sbjct: 17106 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRN 17163

Query: 394   SLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRL 451
              +TLQW  P+ D GS IT Y++E  +       +  F    +    ++ L     Y FR+
Sbjct: 17164 EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17223

Query: 452   AARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITWVTLQWSKPEGCS 502
              A+N  G     S  +  +       +P++   P+     +V AG T+   +        
Sbjct: 17224 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETF---RLEADVHGK 17280

Query: 503   PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSE 561
             P   I +    +E E       K T       VK+  R    ++ L ASN  G KS P  
Sbjct: 17281 PLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVN 17340

Query: 562   VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
             V V     DRPGPP  P+    VTS   S+ W PP  +GGS+I  Y++E  + +  A  W
Sbjct: 17341 VKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLA--W 17394

Query: 622   EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPR 678
              V  S   T     T L  G  Y  R   ++  G  +  ES PV  +   + PG  +   
Sbjct: 17395 TVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLE 17454

Query: 679   VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA---SEVYHGPELECTVGNLLP 735
             V    K   + + W+ P S+ G E+  Y VE  +   +           +L   V  L  
Sbjct: 17455 VTNIAKDS-MTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTE 17513

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESPD- 791
                Y FRV A N  G G  S  +    A  P   PG      I  T    + + W  P  
Sbjct: 17514 DHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIY 17573

Query: 792   SSGADISEYRLEWGE-DEESLELIYHGTD---TRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
               G++I  Y +E  + DEE  +++   T    TRFEI  L    +Y  R+ A N+ G G 
Sbjct: 17574 DGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE 17633

Query: 848   YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-------------------L 888
              +         S P  V     LE   LD   +     +V                   +
Sbjct: 17634 AT---------SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEI 17684

Query: 889   NWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
              W       ++ +     +  T +++ N       D      Y +++    E  +G  S 
Sbjct: 17685 TWSREEGEFTDKVQIEKGVNYTQLSIDNC------DRNDAGKYILKL----ENSSGSKSA 17734

Query: 949   FIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNK 1002
             F+  K    P  P  L        S  L W      G +  K +  +      + E   K
Sbjct: 17735 FVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID------KRESTRK 17788

Query: 1003  RFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR 1061
              + ++    S T +KV+ LTE   Y FR+ A +E G G   ET         P       
Sbjct: 17789 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17848

Query: 1062  VTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             +T +   S  ++WE      G  V  Y++++      ++  V + +     ++GL +  +
Sbjct: 17849 LTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQE 17908

Query: 1121  YRFRVCA 1127
             Y+FRV A
Sbjct: 17909 YQFRVKA 17915



 Score =  145 bits (365), Expect = 3e-34
 Identities = 190/781 (24%), Positives = 303/781 (38%), Gaps = 90/781 (11%)

Query: 361   SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEG 419
             +V G+ SE +             P K+     +S+T+ W+ P +D G+ ++ Y++E  + 
Sbjct: 23443 NVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDA 23502

Query: 420   KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVV--CYTLGNIPQM 477
              R          ++   K T+L     Y FR+AA N  G   Y Q  V  C +   IP  
Sbjct: 23503 HRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 23562

Query: 478   PSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT-CTVK 536
             P   ++       +TL W  PE     +V  Y +E +E   D           +T     
Sbjct: 23563 PETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRST 23622

Query: 537   NLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
              L    +Y+ R+TA N  G    S PS+ +V       PG P  P V    T    S+ W
Sbjct: 23623 GLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVT-DTTRTSVSLAW 23681

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYS--GSATEYTFTHLKPGTLYKLRACCIS 651
               P+D GGS++  YL+E+     + ++W    +      EYT THL  G  Y+ R    +
Sbjct: 23682 SVPEDEGGSKVTGYLIEMQ--KVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACN 23739

Query: 652   TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDVPASESGCEVSEYSVEM 710
              GG  + +E          PG  +   +L  P ++ +   +  +   + G  V   ++ +
Sbjct: 23740 AGGPGEPAE---------VPGTVKVTEMLEYPDYELDERYQEGIFVRQGG--VIRLTIPI 23788

Query: 711   T-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---------- 759
               +P  +      G ++          T     ++  + G  G Y  V E          
Sbjct: 23789 KGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYI 23848

Query: 760   ----ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELI 814
                 I +   P G  +   I       V V W  P D  GADI  Y L   E  E  +  
Sbjct: 23849 KVRVIGSPNSPEGPLEYDDIQVR---SVRVSWRPPADDGGADILGYIL---ERREVPKAA 23902

Query: 815   YHGTDTRFE-----IRDLLPAAQYCCRLQAFNQAGAG---PYSELVLCQTPASAPDPVST 866
             ++  D+R       ++ L    +Y  R+ A NQ G        E V  +TP + P+P S 
Sbjct: 23903 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSN 23962

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTSI--------TVGNT 917
                   E LD    S S    L+W  P ++ GS +  Y I+  +TS         T   T
Sbjct: 23963 ----PPEVLDVTKSSVS----LSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 24014

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTR-PLPPLPPRLECAAAGPQS 973
             TM+ +  L+P+  Y+ RI A N++G     P S+ +  K     P  P  LE  +    S
Sbjct: 24015 TMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDS 24074

Query: 974   LKLKWGDSNSKTHAAEDI----VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
             + L+W     +    ++I    V   Q  D   +  +  R     + +  L E T Y FR
Sbjct: 24075 VTLQW--EKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFR 24132

Query: 1030  IQAASEAG-EGPFSETYTFST--TKSVPPTIK------APRVTQLEGNSCEILWETVPSM 1080
             + A +E G   P     +  T  T    P I+        ++ +    SC+I+   +P +
Sbjct: 24133 VFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDI 24192

Query: 1081  K 1081
             K
Sbjct: 24193 K 24193



 Score =  144 bits (363), Expect = 5e-34
 Identities = 208/860 (24%), Positives = 341/860 (39%), Gaps = 95/860 (11%)

Query: 350   DYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSK 408
             +Y  R+YA+  +     S+P  + T     + P  P++   +KS+++L W  P  D GSK
Sbjct: 12789 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 12848

Query: 409   ITNYLLE-----WDEGKR-NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGY 462
             I  Y +E      D+  R N+   Q     Q+    T L     Y FR  AR  +  S  
Sbjct: 12849 IIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEEKAQYQFRAIARTAVNISPP 12905

Query: 463   SQ--EVVCYTLGNIPQMPSAPRL-VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND 519
             S+  + V     N+P     PR+ +   +  +    +    C    V    +     + D
Sbjct: 12906 SEPSDPVTILAENVP-----PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 12960

Query: 520   N-LFHP----KYTGEDLTCTVK--NLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDR 571
               L  P    K   +   CT++  ++ R     + +TA N+ G KS   ++ V     D+
Sbjct: 12961 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL----DK 13016

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP    +    +     + W+PP ++GGSEI  Y+++  +  S  N  +V+ +   T 
Sbjct: 13017 PGPPASVKINKMYSDRAM-LSWEPPLEDGGSEITNYIVDKRE-TSRPNWAQVSATVPITS 13074

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH 689
              +   L  G  Y+ R C  +  G      +E    +     PG+C PP V+       + 
Sbjct: 13075 CSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPP-VISNITKDHMT 13133

Query: 690   LEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECTVG--NLLPGTVYRFRVRAL 746
             + W  PA + G  ++ Y +E  E + V  ++V   P +E T+    L  GT Y FRV A+
Sbjct: 13134 VSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAI 13193

Query: 747   NDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL 802
             N  G G  SD S+   A     PPG    P +  T    V + W  P    G+ I  Y +
Sbjct: 13194 NKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLV 13253

Query: 803   EWGEDEES----LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
             E    +        L  +   TRFE+  L+   QY  R+ A N+ G   YS+      P+
Sbjct: 13254 EVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG---YSD------PS 13304

Query: 859   SAPDP--VSTLCVLEEEPLDA-----------------YPDSPSACLVLNWEEPCNNGSE 899
               PD      + +  E  LDA                  P        + W +P  N  +
Sbjct: 13305 DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD 13364

Query: 900   ILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
              +   +D+  T         +V K       Y + ++  N  G   ++  +K    P PP
Sbjct: 13365 RIG--LDIKSTDFDTFLRCENVNK--YDAGKYILTLE--NSCGKKEYTIVVKVLDTPGPP 13418

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED-RNKRFISIYRGPSHT-YKV 1017
             +   +        S  + W +       +  I Y +Q  D   K + ++    S T ++V
Sbjct: 13419 V--NVTVKEISKDSAYVTW-EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRV 13475

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETV 1077
               L E   Y FR+ A +E G G   ET         P  +   +V  +  +SC I W+  
Sbjct: 13476 ANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKP 13535

Query: 1078  PSMKGDP-VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQ 1136
              S  G   + Y++  L   E+++++V K     +    L    +Y FRV A        +
Sbjct: 13536 HSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA--------E 13586

Query: 1137  ELSGAFSPSAAFVLQRSEVM 1156
               +G  +PS   V+ R +V+
Sbjct: 13587 NENGEGTPSEITVVARDDVV 13606



 Score =  144 bits (363), Expect = 5e-34
 Identities = 211/906 (23%), Positives = 353/906 (38%), Gaps = 106/906 (11%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKII---YSGEE 337
             KP + N+ +  + L+W  PV      + G S    + V   ++      K+     SG E
Sbjct: 21390 KPVIYNVTSDGMSLTWDAPV------YDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 21443

Query: 338   LECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTL 397
                    L    DY  RVYA  ++   S S+P  FT      + P  P     ++ ++TL
Sbjct: 21444 YRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITL 21501

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
             +W  P+ D GSKI  Y +E  +G  N  + +C F     C+  +T L P   Y FR+ AR
Sbjct: 21502 KWNPPLRDGGSKIVGYSIEKRQG--NERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIAR 21559

Query: 455   NDIGT---SGYSQEVVCYTLGNIPQMPS-APR-----LVRAGITWVTLQWSKPEGCSPEE 505
             N +GT      S  ++     N+P +    P      ++++G +      +  +G     
Sbjct: 21560 NAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIK--ALVQGRPVPR 21617

Query: 506   VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             V  +   ++ ++  N+      G   +  V++  R  +  + + A N  G S  +E+ V 
Sbjct: 21618 VTWFKDGVEIEKRMNMEITDVLGST-SLFVRDATRDHRGVYTVEAKNASG-SAKAEIKVK 21675

Query: 566   TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VA 624
                 D PG    P+    +T    ++ WD P ++G + I  Y++E  + +  A  W  + 
Sbjct: 21676 VQ--DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLA--WALIE 21731

Query: 625   YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV-----RTLSIAPGQCRPPRV 679
                 A  YT   L  G  Y+ R   ++  G  +  +S PV      T+  APG   P  +
Sbjct: 21732 DKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI 21791

Query: 680   LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV--ASEVYHGP--ELECTVGNLLP 735
              G      + L W  P S+ G E+ +Y +E  E +       +   P  E    V  L  
Sbjct: 21792 TG----NSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTE 21847

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESP-D 791
             G  Y F V A N  G GP S +S +        PPG      ++ T    V + W  P  
Sbjct: 21848 GNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVF 21907

Query: 792   SSGADISEYRLEWGEDEESLELIYHGTD------TRFEIRDLLPAAQYCCRLQAFNQAGA 845
               G +I  Y +E  + +      +H  +      TR+ + DL    +Y  R+ A N AG 
Sbjct: 21908 DGGMEIIGYIIEMCKADLG---DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 21964

Query: 846   GPYSEL---VLCQTPASAPDPVSTLCVLEEEPLD---------AYPDSPSACLVLNWEEP 893
             G   E+   +      +AP+        +   +          AY   P+   V  W +P
Sbjct: 21965 GDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAV--WSKP 22022

Query: 894   CNNGSEILAYTIDLGDT----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
              +N    L+   D+  T    ++TV N   +          Y + ++  N  G+   +  
Sbjct: 22023 DSN----LSLRADIHTTDSFSTLTVENCNRN------DAGKYTLTVE--NNSGSKSITFT 22070

Query: 950   IKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDRNKRFI 1005
             +K    P PP P   +    G  S  L W     D  ++ H      Y ++  + ++R  
Sbjct: 22071 VKVLDTPGPPGPITFKDVTRG--SATLMWDAPLLDGGARIHH-----YVVEKREASRRSW 22123

Query: 1006  SIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRV 1062
              +   +     +KV  L E   Y FR+ A +E G G P+        T+   P  +   V
Sbjct: 22124 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLD-V 22182

Query: 1063  TQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDY 1121
                  +S  + W       G  +  Y+L++       + +    ++ TF +  L   T+Y
Sbjct: 22183 VDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEY 22242

Query: 1122  RFRVCA 1127
              FRV A
Sbjct: 22243 EFRVKA 22248



 Score =  143 bits (360), Expect = 1e-33
 Identities = 217/889 (24%), Positives = 336/889 (37%), Gaps = 142/889 (15%)

Query: 336  EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCA-----PECPFPPKLAHR 390
            E  +C++  L    +Y  RV A     K  C  PV             P  P       R
Sbjct: 8878 ERSKCDITGLLEGQEYKFRVIAKN---KFGCGPPVEIGPILAVDPLGPPTSPERLTYTER 8934

Query: 391  SKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPA 444
            +KS++TL WK P  NG S I  Y++E    KR          +++ C  T      L   
Sbjct: 8935 TKSTITLDWKEPRSNGGSPIQGYIIE----KRRHDKPDFERVNKRLCPTTSFLVENLDEH 8990

Query: 445  MGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQMPSAPRLVRA----------------- 486
              Y FR+ A N+IG S  S  + V      +P        VR                  
Sbjct: 8991 QMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADV 9050

Query: 487  -GITWVTLQWSKPEGC--SPEEVITYTLE--IQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
             G+    ++WSK E     P + +  T E   + +    L  PK   ED           
Sbjct: 9051 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED----------- 9099

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             +  + +TASN  G    +   V     DRP PP R L    + +    + WD P DNGG
Sbjct: 9100 -KGTYTVTASNRLGSVFRN---VHVEVYDRPSPP-RNLAVTDIKAESCYLTWDAPLDNGG 9154

Query: 602  SEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHS-QC- 658
            SEI  Y+++  D + +  +W EV  +     Y    L P   Y+ R   ++  G S +C 
Sbjct: 9155 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECK 9214

Query: 659  SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVA 717
            S+ + ++     PG    P+VL R K   + + W  P    G  ++ Y +E  E      
Sbjct: 9215 SDKVVIQDPYRLPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYWLEKREEGSPYW 9273

Query: 718  SEVYHGP-------ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG---PP 767
            S V   P        +E  V  LL G  Y+FR  A+N  G GP S+ S+   A     PP
Sbjct: 9274 SRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPP 9333

Query: 768  GQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGT 818
            G    P +       + +GW+ P    G+ I  Y +E        W    E  +LI   T
Sbjct: 9334 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI---T 9390

Query: 819  DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAY 878
                 + +L    +Y  R++A N+AG    S+    + PA+          ++EEP    
Sbjct: 9391 TCECVVPNLKELRKYRFRVKAVNEAGESEPSD-TTGEIPATD---------IQEEPEVFI 9440

Query: 879  PDSPSACLVLNWEEPCNNGSEILAYTIDLG---------------------------DTS 911
                  CLV      C  GS+I    +  G                           D  
Sbjct: 9441 DIGAQDCLV------CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQ 9494

Query: 912  I-TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAG 970
            + T  N+++ ++ +     T +  I A N+ G    +  +K    P PP   ++     G
Sbjct: 9495 LETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRG 9554

Query: 971  PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRI 1030
               L  K  D +        ++    ++ +    ++   G S T+ V  L     Y FR+
Sbjct: 9555 SCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG-STTFVVPDLLSEQQYFFRV 9613

Query: 1031 QAASEAGEGPFSETYTFSTTKS----VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV- 1085
            +A +  G GP  ET   +T +       P IK  ++  +  N+  + W+   +  G PV 
Sbjct: 9614 RAENRFGIGPPVETIQRTTARDPIYPPDPPIKL-KIGLITKNTVHLSWKPPKNDGGSPVT 9672

Query: 1086 NYILQVLV-----GRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
            +YI++ L       ++  ++Q  K   EE  F +  L    +Y FRV A
Sbjct: 9673 HYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9721



 Score =  142 bits (359), Expect = 1e-33
 Identities = 209/893 (23%), Positives = 365/893 (40%), Gaps = 77/893 (8%)

Query: 284  VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
            ++++   + +L+W PP         G S   +Y V       +  +K+  + ++      
Sbjct: 7420 ITDVTNESCLLTWNPP------RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKAT 7473

Query: 344  DLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L P  +Y  RV A  MY   +   + P++       P  P   + +  +K ++TL W  
Sbjct: 7474 KLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCE 7533

Query: 402  PIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHC--KLTKLCPAMGYTFRLAARNDIG 458
            P D+G S IT Y +E  +   +   R C     K    ++  L     Y FR+ A N  G
Sbjct: 7534 PDDDGGSPITGYWVERLDPDTDKWVR-CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAG 7592

Query: 459  T---SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                S  ++ ++     + P  P  P +   G T V L W+KPE     ++ +Y +E+ +
Sbjct: 7593 PGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLK 7652

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV---LVCTTSPDRP 572
               D               +  L    +Y FR+ A N  G+S PSE    ++C      P
Sbjct: 7653 TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPP 7712

Query: 573  GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
             PP R L    +T +   +KW  P+ +GGS I  Y++E  D   +  Q  V  +   T+ 
Sbjct: 7713 SPP-RWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQ-TVDTTVKDTKC 7770

Query: 633  TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPGQCRPPRVLG--RPKHKE 687
            T T L  G+LY  R    +  G S  +E   S+  +     PG   PP  L       + 
Sbjct: 7771 TVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPG---PPYALAVVDVTKRH 7827

Query: 688  VHLEWDVPASESGCEVSEYSVEMTE---PEDVASEVYHGPELECTVGNLLPGTVYRFRVR 744
            V L+W+ P ++ G  +  Y +E  E      V +    GP+    V +++ GT  +F+VR
Sbjct: 7828 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7887

Query: 745  ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC---VLVGWESPDSSGAD-ISEY 800
            A N+ G G  S+ +EI +   P      P      D     + + W+ P+ +G   I  Y
Sbjct: 7888 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 7947

Query: 801  RLEW---GEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             +E    G ++          D +F++ + ++P  +Y  R++A N  G    SE+   V+
Sbjct: 7948 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 8007

Query: 854  CQTPASAPD---PVSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
             + P   P        + V+E E L    P        ++W +   +G E+ A       
Sbjct: 8008 AKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHK---DGKEVKA------S 8058

Query: 910  TSITVGNTTMHVMKDL-LPETT------YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPP 962
              +T+ N   H+   L +P++       Y I ++  N++G+   S  I  K   LP    
Sbjct: 8059 DRLTMKND--HISAHLEVPKSVRADAGIYTITLE--NKLGSATAS--INVKVIGLPGPCK 8112

Query: 963  RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR-FISIYRGPSH-TYKVQRL 1020
             ++ +     S KL W +          + Y L+  +  +R +I +  G +  ++ V+ L
Sbjct: 8113 DIKASDITKSSCKLTW-EPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDL 8171

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCE---ILWETV 1077
                 Y FR++A ++ G G + E       +        P   ++   + E   I W+  
Sbjct: 8172 IPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP 8231

Query: 1078 PSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
                G  +  YI++ +   E  +K+  +      T+   GL+   +Y+FRV A
Sbjct: 8232 LYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRA 8284



 Score =  142 bits (359), Expect = 1e-33
 Identities = 212/900 (23%), Positives = 347/900 (38%), Gaps = 98/900 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +++ + +   +LSW PP+        G S   +Y V   +  R    ++  +     C++
Sbjct: 13024 KINKMYSDRAMLSWEPPL------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSV 13077

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
             + L    +Y  R+ A   Y       +EP         P    PP +++ +K  +T+ WK
Sbjct: 13078 EKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWK 13137

Query: 401   APIDN-GSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              P D+ GS IT YLLE        W +  R           ++  K T L     Y FR+
Sbjct: 13138 PPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-------ERTLKATGLQEGTEYEFRV 13190

Query: 452   AARNDIG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
              A N  G    S  S+          P  P+ P++     + V+L W KP       +I 
Sbjct: 13191 TAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIG 13250

Query: 509   YTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             Y +E++  ++DN        ++L  T   V  L   TQY+FR+ A N  G S PS+V   
Sbjct: 13251 YLVEVKRADSDNWVRCNLP-QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDK 13309

Query: 566   TTSPDRPGPPTRPL---------VKGPVTSHGF-SVKWDPPKDNGGSEILKYLLEITDGN 615
                 D   PP   L         ++  VT   +  VK  PP             +IT   
Sbjct: 13310 HYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP------------KITWSK 13357

Query: 616   SEAN-QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQC 674
                N +  +     +T++  T L+   + K  A        + C +      + +     
Sbjct: 13358 PNVNLRDRIGLDIKSTDFD-TFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13416

Query: 675   RPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---- 729
              P  V  +   K+  ++ W+ P  + G  +  Y V   +  D   + +     EC+    
Sbjct: 13417 PPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV---QKRDAERKSWSTVTTECSKTSF 13473

Query: 730   -VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE 788
              V NL  G  Y FRV A N+ G G   +  +   A+  PG      +         +GW+
Sbjct: 13474 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWK 13533

Query: 789   SPDSSGAD-ISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
              P S G   I  Y +++  +E   + +      ++  +DL    +Y  R+ A N+ G G 
Sbjct: 13534 KPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGT 13593

Query: 848   YSEL-VLCQTPASAPD----PVSTLCVLEEE--------PLDAYPDSPSACLVLNWEEPC 894
              SE+ V+ +    APD     +  LC L +E        P+   P +PS    ++W++  
Sbjct: 13594 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP-APS----VSWKK-- 13646

Query: 895   NNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
               G + LA    +   S  V NTT+ ++ D       +  I   N  G    +  IK   
Sbjct: 13647 --GEDPLATDTRVSVESSAV-NTTL-IVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVG 13702

Query: 955   RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED--RNKRFISIYRGPS 1012
             +P  P  P ++      +++ LKW         +E   Y L+  D   NK          
Sbjct: 13703 KPGIPTGP-IKFDEVTAEAMTLKWAPPKD-DGGSEITNYILEKRDSVNNKWVTCASAVQK 13760

Query: 1013  HTYKVQRLTEFTCYSFRIQAASE--AGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC 1070
              T++V RL E   Y+FR+ A ++   GEG  SE         VP     P +  +  +S 
Sbjct: 13761 TTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSV 13820

Query: 1071  EILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              + W       G P+  Y L+        +K+  K       F+++GL    +Y FRV A
Sbjct: 13821 SLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMA 13880



 Score =  142 bits (358), Expect = 2e-33
 Identities = 226/946 (23%), Positives = 363/946 (38%), Gaps = 128/946 (13%)

Query: 260   SDLQEYELEVKRVQDILSG------IEKPQV-------SNIQARAVVLSWAPPVGLSCGP 306
             SD  +Y + +K V     G      + KP +         + A A+ L WAPP       
Sbjct: 13676 SDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPP------K 13729

Query: 307   HSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYA--MYNSVKG 364
               G S   +Y +   D   +       + ++    +  L    +Y  RV A   Y   +G
Sbjct: 13730 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEG 13789

Query: 365   SCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNS 423
               SEP+        P+ P PP +      S++L W  P   G S IT Y LE+ E  RNS
Sbjct: 13790 LKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE--RNS 13847

Query: 424   GFRQCFFGS---QKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
                +    +    +  K+T L   + Y FR+ A N  G    S         +    P  
Sbjct: 13848 LLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK 13907

Query: 481   PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTG-EDLTCTVKNLK 539
             P ++      VTL W++P+     ++  Y +E ++  + +     +    +   TV +L 
Sbjct: 13908 PEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLV 13967

Query: 540   RSTQYKFRLTASNTEGK-SCPSE---VLVCTTSPDRPGPPTRPLVKGPVTS--------H 587
                +Y+FR+ A NT G  S PSE    ++C    + P     P +K  +T         +
Sbjct: 13968 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLN 14027

Query: 588   GFSVKWDP-PKDN---GGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP-G 640
               S+   P PK +    G +I    +        ++   + Y+    A EYT T   P G
Sbjct: 14028 AISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14087

Query: 641   TLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESG 700
             T                  E + V  L + PG   P  +      K   L W  P  + G
Sbjct: 14088 TKV----------------EHVKVTVLDV-PGPPGPVEISNVSAEKAT-LTWTPPLEDGG 14129

Query: 701   CEVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGP--YSD 756
               +  Y +E  E   +   V       C      L+ G  Y FRV A+N  G G    S+
Sbjct: 14130 SPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSE 14189

Query: 757   VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIY 815
               ++    GPPG  + P +S        V W+ P D  G++I+ Y +E  E ++SL  + 
Sbjct: 14190 PVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE-KKSLRWVR 14248

Query: 816   H----GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLC 868
                   +D R ++  L   + Y  R+ A N+AG GP SE    VL +  A  P P S   
Sbjct: 14249 AIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPH 14308

Query: 869   VLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID---------LGDTSITVGNTT 918
             V          D+      L W +P  + G EI  Y ++         + DT+ T    T
Sbjct: 14309 VT---------DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14359

Query: 919   MHVMKDLLPETTYRIRIQAINEIGAG-----PFSQFIKAKTRPLPPLPPRLECAAAGPQS 973
               V+ DL  +  Y  RI AIN+ G G     P  + ++ +      + P  E  A   ++
Sbjct: 14360 QFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVERE------MAPDFELDAELRRT 14413

Query: 974   LKLKWGDS-----NSKTHAAEDIVYT---LQLEDRNKRFISIYRGPSHTYK-VQRLTEFT 1024
             L ++ G S       K   A ++ +T   + L++R     +I    S T   +     + 
Sbjct: 14414 LVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNR----ANIENTESFTLLIIPECNRYD 14469

Query: 1025  CYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP 1084
                F +   + AG+      +        P  +   R T +  +S  + W+ +P + G  
Sbjct: 14470 TGKFVMTIENPAGK---KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWD-LPLIDGGS 14525

Query: 1085  --VNYILQVLVGRESEYK-QVYKGEEATFQISGLQTNTDYRFRVCA 1127
                NYI++        Y     K  + T++++GL    +Y FRV A
Sbjct: 14526 RITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMA 14571



 Score =  142 bits (358), Expect = 2e-33
 Identities = 222/931 (23%), Positives = 360/931 (38%), Gaps = 93/931 (9%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S      +  ++  +V LSW PP+        G +   +Y V   +  R     
Sbjct: 18822 RVLDSPSAPVNLTIREVKKDSVTLSWEPPL------IDGGAKITNYIVEKRETTRKAYAT 18875

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPP-- 385
             I  +  +    +++L+    Y+ RV A       +    +EPV  +      E P PP  
Sbjct: 18876 ITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVS------EPPLPPGR 18929

Query: 386   -KLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
               L   ++++ T++W+ P  D GSKIT Y++E  + K +  +  C         ++ L  
Sbjct: 18930 VTLVDVTRNTATIKWEKPESDGGSKITGYVVEM-QTKGSEKWSTCTQVKTLEATISGLTA 18988

Query: 444   AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA--PRLVRAGITWVTLQWSKPEGC 501
                Y FR+AA N+ G S   Q  V     +I   PS   P           L+   P   
Sbjct: 18989 GEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKG 19048

Query: 502   SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPS 560
              P+  + +  + Q  +     +   +    + ++K   +     + L  SN+ G  + P 
Sbjct: 19049 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 19108

Query: 561   EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQ 620
              ++V     DRPGPP  P+    V+    ++ W+PP+ +GG +I  Y++E  +  S    
Sbjct: 19109 TIIVL----DRPGPPG-PIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTS--TT 19161

Query: 621   WEVAYSGSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
             W +     A T      L  G+ Y+ R C  +  G S  SES  V    +A     PP  
Sbjct: 19162 WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV----VAEYPFSPPGP 19217

Query: 680   LGRPK-----HKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTV 730
              G PK        + + W VP ++ G  V  Y +E  E   +    A+++    + +  V
Sbjct: 19218 PGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIA-DTQMKV 19276

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGW 787
               L  G +Y +RV A N  G G  S   E   A     PPGQ   P ++      V + W
Sbjct: 19277 SGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQ---PEVTNITRKSVSLKW 19333

Query: 788   ESPD-SSGADISEYRLEWGE--DEESLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQA 843
               P    GA I+ Y +E  E  D   L+  Y    +T FE+ +L    +Y  R+ A N A
Sbjct: 19334 SKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAA 19393

Query: 844   GAGPYSELVLCQTPASAPDPV------------STLCVLEEEPLDAYPDSPSACL-VLNW 890
              +   SE      P    D V              + V   E L    D     L V++W
Sbjct: 19394 DS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19451

Query: 891   EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
                  +G EI           I+  N T+  +KD +   T +  +   N  G    +   
Sbjct: 19452 ---AKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNC 19505

Query: 951   KAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
             K   +P PP  P LE      +   L WG       A  D  Y ++  + +    +I  G
Sbjct: 19506 KVLDKPGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADID-YYIVEKRETSHLAWTICEG 19563

Query: 1011  PSH--TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK--SVPPTIKAPRVTQLE 1066
                  + KV +L +   Y FR+   ++ G G   E+         +VP    +  +T + 
Sbjct: 19564 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19623

Query: 1067  GNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKGEEATFQI--SGLQTNTDYRF 1123
               S  + W    S  G  ++ YI++        + +V K      ++  +GL+   +Y +
Sbjct: 19624 KESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEY 19683

Query: 1124  RVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             RV A        +  +G   PS    L R+E
Sbjct: 19684 RVYA--------ENAAGLSLPSETSPLIRAE 19706



 Score =  141 bits (355), Expect = 4e-33
 Identities = 217/905 (23%), Positives = 352/905 (38%), Gaps = 95/905 (10%)

Query: 292   VVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
             +V+SW PP+        G S   +Y +   + G+D    +  +  +  C +  L    DY
Sbjct: 10557 MVISWKPPLD------DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDY 10610

Query: 352   HVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKI 409
               R++A  +Y       S+ +        P+ P  P +   +K S  + W  P D G  I
Sbjct: 10611 IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPI 10670

Query: 410   TNYLLEWDE--GKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG---TSGYSQ 464
             TNY+LE  E   KR +   +         ++  L     Y FR++A N+IG    S  S+
Sbjct: 10671 TNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSK 10730

Query: 465   EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
              V        P  P  P  +      V L W  P      +++ Y +E Q+  ++     
Sbjct: 10731 PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRA 10790

Query: 525   KYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP------ 575
              +T E    T   V  L+    YKFR+ A N  G+S P+ V       DR  PP      
Sbjct: 10791 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDA 10850

Query: 576   ----TRPLVKGPVTSHGFSVKWDP-PKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
                  + +  G        +K  P PK       + +  E  D  ++A + +V   GS  
Sbjct: 10851 NMAREQHIKVGDTLRLSAIIKGVPFPK-------VTWKKEDRDAPTKA-RIDVTPVGSKL 10902

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI-APGQCRPPRVL--GRPKHKE 687
             E      + G +Y L      T  +   S+++ V+ L +  PG   PPR L     +   
Sbjct: 10903 EIRNAAHEDGGIYSL------TVENPAGSKTVSVKVLVLDKPG---PPRDLEVSEIRKDS 10953

Query: 688   VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH-----GPELECTVGNLLPGTVYRFR 742
              +L W  P  + G  ++ Y VE     DVAS  +        +      +L  G  Y FR
Sbjct: 10954 CYLTWKEPLDDGGSVITNYVVER---RDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFR 11010

Query: 743   VRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             V A N  G GP+ +  +   A     PPG  K           V + W  PD   G+ I+
Sbjct: 11011 VAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT 11070

Query: 799   EYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAG-PYSEL-VLC 854
              Y +E+ ++E + + I   T T  E  +  L     Y  R++A N  G G P + + + C
Sbjct: 11071 GYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIEC 11129

Query: 855   QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP----CNNGSEILA---YTIDL 907
             Q     P     + ++E   + A        ++     P      +GSEI     YT++ 
Sbjct: 11130 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVET 11189

Query: 908   GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECA 967
              + S      ++  +K+ L   T   +I   N  G+   +  +     P PP  P +   
Sbjct: 11190 DNFS------SVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP-INIL 11242

Query: 968   AAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLED-RNKRFISIYRGPSHT-YKVQRLTEFT 1024
                P+ + + W     K      ++ Y ++ +D R   +  +  G S T  K+  L +  
Sbjct: 11243 DVTPEHMTISW--QPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGC 11300

Query: 1025  CYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKG 1082
              Y FR++A ++ G G P   T T +  K  PP+    P VT +  N+  + W    S  G
Sbjct: 11301 EYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGG 11360

Query: 1083  DPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
              P+            ++ +V K    +  F+++GL     Y FRV A        + L+G
Sbjct: 11361 SPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFA--------ENLAG 11412

Query: 1141  AFSPS 1145
                PS
Sbjct: 11413 LSKPS 11417



 Score =  140 bits (353), Expect = 7e-33
 Identities = 167/655 (25%), Positives = 264/655 (40%), Gaps = 55/655 (8%)

Query: 281  KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
            KP V ++   +V L+W  P       H G +   SY + +   G D   ++       + 
Sbjct: 7617 KPTVKDVGKTSVRLNWTKP------EHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQH 7670

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTL 397
             L  L    +Y  RV A+  + +   SEP            P PP+   + + +K++  L
Sbjct: 7671 LLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADL 7730

Query: 398  QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
            +W  P  D GS ITNY++E  + +R              C +T L     Y FR+AA N 
Sbjct: 7731 KWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENA 7790

Query: 457  IGTSGYSQ---EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
            IG S Y++    V+       P  P A  +V      V L+W  P+      +  Y +E 
Sbjct: 7791 IGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEK 7850

Query: 514  QEDENDNLFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
            +E          K  G D    V ++   T+ +F++ A N  G   PSE     +  D  
Sbjct: 7851 KERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPT 7910

Query: 573  GPPTRPLVKGPVTSHG---FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             PP+ PL    VT  G    ++ W PP+ NGGS I+ Y +E+    +E  +W    S   
Sbjct: 7911 SPPSPPLDLH-VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTE--KWMRVNSRPI 7967

Query: 630  TEYTF---THLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK 686
             +  F     + P   Y LR   ++  G S+ SE +    ++  P  C+P   +    H 
Sbjct: 7968 KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSE-ISENVVAKDP-DCKP--TIDLETHD 8023

Query: 687  EVHLEWD---VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR--- 740
             + +E +   +P       V   S      E  AS+         +    +P +V     
Sbjct: 8024 IIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAG 8083

Query: 741  -FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             + +   N  G    S   ++    GP    KA  I  T   C L  WE P+   G  I 
Sbjct: 8084 IYTITLENKLGSATASINVKVIGLPGPCKDIKASDI--TKSSCKLT-WEPPEFDGGTPIL 8140

Query: 799  EYRLEWGEDEESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             Y LE  E      +     + +  + ++DL+P  +Y  R++A N+ G G Y EL   V+
Sbjct: 8141 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8200

Query: 854  CQTPASAPDPVSTLCVLEEEPLDAYPDSPSA-CLVLNWEEPC-NNGSEILAYTID 906
             Q P   PDP          P+D    +P+A  + + W+ P  + GS+I+ Y I+
Sbjct: 8201 AQDPKQPPDP----------PVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIE 8245



 Score =  140 bits (352), Expect = 9e-33
 Identities = 225/902 (24%), Positives = 350/902 (38%), Gaps = 115/902 (12%)

Query: 257  SNDSDLQEYELEVKRVQDILSG------IEKPQV------SNIQARAVVLSWAPPVGLSC 304
            S  SD   Y L+++     +SG      I +P         +I   +V L+W PP     
Sbjct: 7085 SERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGG 7144

Query: 305  GPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKG 364
             P +G      Y V   +  R    K++    +LE  + DL    +Y  +V A      G
Sbjct: 7145 SPLTG------YVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPG 7198

Query: 365  S---CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGK 420
                  EPV+ +T +  P+ P   K   R+ +S+ L W  P  D GS+I  Y++E     
Sbjct: 7199 EPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVE----- 7253

Query: 421  RNSGFRQCFFGSQK-----------HCKLTKLCPAMGYTFRLAARNDIGTSGYS---QEV 466
                  +C  GS K             ++T L     Y +R+ A N  G S  S   +E+
Sbjct: 7254 ------RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEI 7307

Query: 467  VCYTLGNIPQMPSAPRLVRAGIT---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFH 523
                    P++    +L+ AG+T      ++        PE  IT+T      + D    
Sbjct: 7308 QAVDTQEAPEIFLDVKLL-AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRIT 7366

Query: 524  PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
             +   +  T T+ + KRS    + + A N  G++     +V     D+PGPP    +   
Sbjct: 7367 IENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRAT---AVVEVNVLDKPGPPAAFDITD- 7422

Query: 584  VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTL 642
            VT+    + W+PP+D+GGS+I  Y++E    +SE   W +++ +   T +  T L P   
Sbjct: 7423 VTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV--WHKLSSTVKDTNFKATKLIPNKE 7480

Query: 643  YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE--------VHLEWDV 694
            Y  R    +  G  +  ++ P+     A  Q  PP   G P   E        V L W  
Sbjct: 7481 YIFRVAAENMYGVGEPVQASPI----TAKYQFDPP---GPPTRLEPSDITKDAVTLTWCE 7533

Query: 695  PASESGCEVSEYSVEMTEPE-DVASEVYHGPELECT--VGNLLPGTVYRFRVRALNDGGY 751
            P  + G  ++ Y VE  +P+ D        P  + T  V  L     YRFRV A N  G 
Sbjct: 7534 PDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGP 7593

Query: 752  GPYSDVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE- 806
            G  S  +E   I     PP     P +       V + W  P+   GA I  Y +E  + 
Sbjct: 7594 GKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKT 7653

Query: 807  -DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE---LVLCQTPASAPD 862
              +E + +      T+  +  L+   +Y  R++A N+AG    SE    VLC+     P 
Sbjct: 7654 GTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPS 7713

Query: 863  PVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTIDLGDTSITVGNTTMHV 921
            P   L V+      A          L W  P  + GS I  Y ++  D       T    
Sbjct: 7714 PPRWLEVINITKNTA---------DLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 7764

Query: 922  MKD-------LLPETTYRIRIQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAG 970
            +KD       L   + Y  R+ A N IG   +++    + AK     P PP  L      
Sbjct: 7765 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVT 7824

Query: 971  PQSLKLKWGDSNSKTHAAEDIV-YTLQLEDR-NKRFISIYR--GPSHTYKVQRLTEFTCY 1026
             + + LKW     K      I  Y ++ ++R   R++   +  GP   ++V  + E T  
Sbjct: 7825 KRHVDLKW--EPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 7882

Query: 1027 SFRIQAASEAGEGPFS---ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             F+++A +EAG G  S   E  +     S P       VT        I W+      G 
Sbjct: 7883 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 7942

Query: 1084 PV 1085
            P+
Sbjct: 7943 PI 7944



 Score =  140 bits (352), Expect = 9e-33
 Identities = 224/898 (24%), Positives = 357/898 (39%), Gaps = 91/898 (10%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             + +I    V L+W  P       H G S    Y +    KG D ++  I + + LEC ++
Sbjct: 14601 IMDITKSTVSLAWPKP------KHDGGSKITGYVIEAQRKGSD-QWTHITTVKGLECVVR 14653

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSE--PVSFTTHSCAPECPFP---PKLAHRSKSSLTLQ 398
             +L    +Y  +V A+ ++ + +  E  PV     +  PE        KL   +K+   ++
Sbjct: 14654 NLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVI-AKAGDNIK 14712

Query: 399   WKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAAR 454
              + P+    K T   + W +G    K+          +     + +   +    + L AR
Sbjct: 14713 VEIPVLGRPKPT---VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTAR 14769

Query: 455   NDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             N +G  G   +V+   + +IP  P+ P +       +VT  W  PE      +  Y +E+
Sbjct: 14770 NIVGEVG---DVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 14826

Query: 514   QEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLVCTTSPDR 571
             ++ ++        T    T     L    +Y+FR+ A N  G      S  +V       
Sbjct: 14827 RQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKV 14886

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP  P V   VT    ++ W  P  +GGS IL Y +E  + N    Q           
Sbjct: 14887 PGPPGTPQVTA-VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 14945

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIA--PGQCRPPRVLGRPKHKEV 688
             +  + L  G  Y+ R    +  G S+ S+ S P+  L     PG+   P  L   +H  V
Sbjct: 14946 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK---PVPLNITRHT-V 15001

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRA 745
              L+W  P    G +++ Y VE  +  +   + +   +  E E TV  L     Y FRV A
Sbjct: 15002 TLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIA 15061

Query: 746   LNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY---R 801
              N  G   P S+ S+  T        K        D  +L   E+     AD+S      
Sbjct: 15062 KNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLE-ADVSGRPPPT 15120

Query: 802   LEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP 861
             +EW +D + LE    GT  + EI+     A +   L   +       +  +    P    
Sbjct: 15121 MEWSKDGKELE----GT-AKLEIK----IADFSTNLVNKDSTRRDSGAYTLTATNPGGFA 15171

Query: 862   DPVSTLCVLE-----EEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTS---- 911
               +  + VL+     E PL     +   C VL+W  P ++G ++I  Y +   +TS    
Sbjct: 15172 KHIFNVKVLDRPGPPEGPLAVTEVTSEKC-VLSWFPPLDDGGAKIDHYIVQKRETSRLAW 15230

Query: 912   ----ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPPLPPRL- 964
                   V  T + V K LL    Y  R+ A+N+ G G    S+ + A     PP PP+  
Sbjct: 15231 TNVASEVQVTKLKVTK-LLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNP 15289

Query: 965   ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKRFISIYRGPSHTYK 1016
             E       S+ + WG  +S    +E I Y ++  D+        NK+ ++  R     YK
Sbjct: 15290 EVTTITKDSMVVCWGHPDSDG-GSEIINYIVERRDKAGQRWIKCNKKTLTDLR-----YK 15343

Query: 1017  VQRLTEFTCYSFRIQAASEAG---EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEIL 1073
             V  LTE   Y FRI A + AG     P S  Y    T   P     PRV     +S  I 
Sbjct: 15344 VSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIA 15403

Query: 1074  WETVPSMKGDPV-NYILQVLVGRESEYKQVY--KGEEAT-FQISGLQTNTDYRFRVCA 1127
             W       G  +  Y++++ +  E E++ V    G +AT + I+GL  N +Y+ R+ A
Sbjct: 15404 WNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15461



 Score =  139 bits (351), Expect = 1e-32
 Identities = 213/920 (23%), Positives = 344/920 (37%), Gaps = 85/920 (9%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE 317
             N    +EY + VK V D         V  I   +  ++W PP+        G S   +Y 
Sbjct: 13398 NSCGKKEYTIVVK-VLDTPGPPVNVTVKEISKDSAYVTWEPPI------IDGGSPIINYV 13450

Query: 318   VALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC 377
             V   D  R     +     +    + +L     Y  RV+A      G   E       S 
Sbjct: 13451 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13510

Query: 378   APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQK 434
              P      K+   SKSS ++ WK P  D GS+I  Y++++  +E K    +++       
Sbjct: 13511 TPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK----WQRVMKSLSL 13566

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIP----QMPSAPRLVRAGITW 490
                   L     YTFR++A N+ G  G   E+      ++      +   P L       
Sbjct: 13567 QYSAKDLTEGKEYTFRVSAENENG-EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKEN 13625

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
                +   P    P   +++         D     + +  + T  V + ++S   K+ +T 
Sbjct: 13626 SNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITL 13685

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G     E  +      +PG PT P+    VT+   ++KW PPKD+GGSEI  Y+LE
Sbjct: 13686 KNVAGTK---EGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILE 13742

Query: 611   ITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTL 667
               D  S  N+W    S    T +  T L  G  Y  R    +  G  +  +S P+  R  
Sbjct: 13743 KRD--SVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHP 13800

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPEL- 726
                P    PP ++   +H  V L W  P    G  ++ Y +E  E   +  +  +   + 
Sbjct: 13801 FDVPDAPPPPNIVD-VRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIR 13859

Query: 727   --ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDG 781
               +  V  L  G  Y FRV A+N  G G  S  SE   A     PPG  K   I+ T + 
Sbjct: 13860 MRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG--KPEVINITRNS 13917

Query: 782   CVLVGWESPDSSGADISEYRLEWGE-DEESLELIYHGT--DTRFEIRDLLPAAQYCCRLQ 838
               L+  E     G  ++ Y +E  +   +S     H    +  F + DL+   +Y  R++
Sbjct: 13918 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13977

Query: 839   AFNQAGA----GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN----W 890
             A N AGA       +E ++C+    AP       VL+    D         +VLN     
Sbjct: 13978 AKNTAGAISAPSESTETIICKDEYEAP-----TIVLDPTIKDGLTIKAGDTIVLNAISIL 14032

Query: 891   EEPCNNGSEILAYTIDLGDTSIT----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPF 946
              +P    S   A   D+  + IT       ++M  +K    +      I A N  G    
Sbjct: 14033 GKPLPKSSWSKAGK-DIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK-- 14089

Query: 947   SQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAED-----IVYTL 995
              + +K     +P  P  +E +    +   L W      G S  K++  E      +++T+
Sbjct: 14090 VEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTV 14149

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
               ED            S  +   +L +   Y FR+ A +  G+G    SE          
Sbjct: 14150 VSEDIQ----------SCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGP 14199

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATF 1110
             P   + P V+ +  N+  + W+      G  +  Y ++    +   + +  K    +   
Sbjct: 14200 PGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 14259

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             +++GLQ  + Y FRV A  R
Sbjct: 14260 KVTGLQEGSTYEFRVSAENR 14279



 Score =  136 bits (343), Expect = 1e-31
 Identities = 209/842 (24%), Positives = 320/842 (38%), Gaps = 80/842 (9%)

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWK 400
             DL     Y  RV A      G   E +  TT       P PP   K+   +K+++ L WK
Sbjct: 9602  DLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWK 9661

Query: 401   API-DNGSKITNYLLE---WDE-GKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
              P  D GS +T+Y++E   WD  G +   +RQC     +  + T   L     Y FR+ A
Sbjct: 9662  PPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9721

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR----------------AGITWVTLQWSK 497
              N  G S  S  V        P MP +  L                   G+ + TL W K
Sbjct: 9722  VNAAGVSKPSATVGPCDCQR-PDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFK 9780

Query: 498   PEGCSPE--EVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
                  P+  E + Y   + +   D+           TCT  +   +RS    + +TA N 
Sbjct: 9781  APPKKPDNKEPVLYDTHVNKLVVDD-----------TCTLVIPQSRRSDTGLYTITAVNN 9829

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITD 613
              G +     L       RPGPP  P+    V++   ++ W PPKD+GGS+I  Y++E  +
Sbjct: 9830  LGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKRE 9886

Query: 614   GNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIA 670
              N +   W  V+       YT   L  G  Y  R    +  G  +  +S P   R L   
Sbjct: 9887  ANRKT--WVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSV 9944

Query: 671   PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT 729
             PG    P V    ++  + + W+ P  + G  V+ Y +EM +        V   P    T
Sbjct: 9945  PGAPDKPTVSSVTRN-SMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMT 10003

Query: 730   VG------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP--PGQCKAPCISCTPDG 781
             +G       L+ G+ Y+FRV A+N  G GP S  S+  TA  P  P     P ++     
Sbjct: 10004 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKS 10063

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGTD-----TRFEIRDLLPAAQYCC 835
                + W  P    G+ ++ Y +E+   EE  E    G D     T+  +  L   A Y  
Sbjct: 10064 SADLEWSPPLKDGGSKVTGYIVEY--KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKF 10121

Query: 836   RLQAFNQAGAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP 893
             R++A N AG G   E+  + +       P   L     + +  +       +  ++ + P
Sbjct: 10122 RVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPP 10181

Query: 894   CNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                   +   T+    T  T   ++  V+K+          + A NE G    +  +   
Sbjct: 10182 PTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10241

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKW-GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPS 1012
               P P   P L       +S KL W    +       + V   +  DR       Y    
Sbjct: 10242 DVPGPVGTPFLAHNLTN-ESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTR 10300

Query: 1013  HTYKVQRLTEFTCYSFRIQAASEAGEGPF---SETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                 VQ L +   Y FRI A +  G GPF   SE        +VP   +   V ++  N+
Sbjct: 10301 QNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNT 10360

Query: 1070  CEILWETVPSMKG--DPVNYILQV-LVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRV 1125
               + W   P   G  + +NY+L+  L+G E  +K          + + GL+    Y +RV
Sbjct: 10361 VTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10419

Query: 1126  CA 1127
              A
Sbjct: 10420 SA 10421



 Score =  136 bits (343), Expect = 1e-31
 Identities = 208/839 (24%), Positives = 321/839 (38%), Gaps = 83/839 (9%)

Query: 342   LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQ 398
             + DL     Y+ RV A+     G   EP        A E P PP+   +   SKSS  L 
Sbjct: 22137 VNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLA 22193

Query: 399   WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
             W  P  D GS+IT YLLE  + K +  + +     Q    + +L     Y FR+ A+ND 
Sbjct: 22194 WLKPDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND- 22251

Query: 458   GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCS------PEEVITY 509
               +GYS+    ++   I +    P     GIT   +T +   P          P   +T+
Sbjct: 22252 --AGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTW 22309

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
              LE    +  +      T +  T TVK+  R    ++ LT  NT G    S  +V     
Sbjct: 22310 KLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI--- 22366

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-S 628
              RPGP T P+    V++    + W  PKD GG+EI  Y++E  +  + A  W++  S   
Sbjct: 22367 GRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTA--WQLVNSSVK 22424

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
              T+   THL     Y  R    +  G S+  ES P+    IA     PP    RP+   V
Sbjct: 22425 RTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPI----IAEHPFVPPSAPTRPEVYHV 22480

Query: 689   -----HLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT--VGNLLPGTVYR 740
                   + W+ P  + G ++  Y VE  E   +   +    P LEC   V  L+ G  Y+
Sbjct: 22481 SANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQ 22540

Query: 741   FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISE 799
             FR  ALN  G    S+ S    A  P      P ++      V + W +P    G+ +  
Sbjct: 22541 FRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVG 22600

Query: 800   YRLEWGE-----DEESLELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAG--------A 845
             Y +E        D   L+  Y   +D  F +  L     Y  R+ A N AG         
Sbjct: 22601 YIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST 22660

Query: 846   GPYSELVLCQTPASAP---------DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN 896
             GP    V C+   + P           + T+    +  LDA         ++ W +   +
Sbjct: 22661 GP----VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKII-WTK--GD 22713

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
                 L   + L  T    G     V+K      + +  +   N  G    S  +K    P
Sbjct: 22714 KELDLCEKVSLQYT----GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 22769

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG--PSHT 1014
              P    +L  +    +   L W     +   AE   Y ++  + ++    I  G  P+ +
Sbjct: 22770 GP--CGKLTVSRVTQEKCTLAW-SLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLS 22826

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEG--PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             Y V RL +   Y FR++A ++ G G    SE      + ++P     P           I
Sbjct: 22827 YVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIII 22886

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQV---YKGEEATFQISGLQTNTDYRFRVCA 1127
              W    S  G+ + NY++     +   + +V   Y   +   +++ L    DY+FRV A
Sbjct: 22887 QWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTA 22945



 Score =  136 bits (342), Expect = 1e-31
 Identities = 223/927 (24%), Positives = 346/927 (37%), Gaps = 101/927 (10%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKP-QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSY 316
             N S   + E++VK VQD    +  P + +NI    + L W  P+   C P +       Y
Sbjct: 21663 NASGSAKAEIKVK-VQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT------HY 21715

Query: 317   EVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTT 374
              +   +  R     I    E        L    +Y  RV A+     G    S+PV    
Sbjct: 21716 IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQI 21775

Query: 375   HSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-- 431
                 P+ P  P+ ++ + +S+TL W  P  D GS+I  Y+LE  E K     +       
Sbjct: 21776 QYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPI 21835

Query: 432   SQKHCKLTKLCPAMGYTFRLAARNDIGT---SGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
             S+   K+T L     Y F + A N  G    SG S+ + C    N P  P+  ++     
Sbjct: 21836 SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSK 21895

Query: 489   TWVTLQWSKPEGCSPEEVITYTLEI-QEDENDNLFHPKYTGE---DLTCTVKNLKRSTQY 544
             T V+L+WSKP      E+I Y +E+ + D  D  +H K   E       TV +L+   +Y
Sbjct: 21896 TTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD--WH-KVNAEACVKTRYTVTDLQAGEEY 21952

Query: 545   KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVK-------- 592
             KFR++A N  GK    EV     + DR   P   +      +H    G S++        
Sbjct: 21953 KFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGR 22012

Query: 593   ------WDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
                   W  P  N     L+  +  TD  S     E      A +YT T           
Sbjct: 22013 PTPTAVWSKPDSNLS---LRADIHTTDSFSTLTV-ENCNRNDAGKYTLT----------- 22057

Query: 647   ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEY 706
                 +  G    + ++ V      PG    P            L WD P  + G  +  Y
Sbjct: 22058 --VENNSGSKSITFTVKVLDTPGPPG----PITFKDVTRGSATLMWDAPLLDGGARIHHY 22111

Query: 707   SVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGPYSDVSEIT 761
              VE  E    + +V      +CT     V +L  G  Y FRV A+N+ G G   ++ E  
Sbjct: 22112 VVEKREASRRSWQVI---SEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPI 22168

Query: 762   TAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL-IYHGTD 819
              A   P   +   +  T     ++ W  PD   G+ I+ Y LE  +      +   H   
Sbjct: 22169 VATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ 22228

Query: 820   TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE------LVLCQTPASAPDPVSTLCVLEEE 873
               F +  L+   +Y  R++A N AG   YSE       V+ + P    +P + L  +  +
Sbjct: 22229 LTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEPQI--EPTADLTGITNQ 22283

Query: 874   PLDAYPDSPSACLVLNWEEPCNNGS----EILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
              +     SP    V     P    +    E+     D    + T   TT+ V KD +   
Sbjct: 22284 LITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV-KDSMRGD 22342

Query: 930   TYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
             + R  +   N  G   FS  +    RP P   P +E ++   +S  L WG+         
Sbjct: 22343 SGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGEPKDGGGTEI 22401

Query: 990   DIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTF 1047
                   + E     +  +      T  KV  LT++  YSFR+ + +  G   P       
Sbjct: 22402 TNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPII 22461

Query: 1048  STTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGE 1106
             +    VPP+    P V  +  N+  I WE       D  + I+   V ++     ++  E
Sbjct: 22462 AEHPFVPPSAPTRPEVYHVSANAMSIRWE---EPYHDGGSKIIGYWVEKKERNTILWVKE 22518

Query: 1107  ------EATFQISGLQTNTDYRFRVCA 1127
                   E  ++++GL    +Y+FR  A
Sbjct: 22519 NKVPCLECNYKVTGLVEGLEYQFRTYA 22545



 Score =  135 bits (341), Expect = 2e-31
 Identities = 234/959 (24%), Positives = 370/959 (38%), Gaps = 149/959 (15%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             +KP VS++   ++ ++W  P      P +G         +   K R  +  I      + 
Sbjct: 9949  DKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK-RVNRDPIKAMTLGVS 10007

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT--HSCAPECPFPPKLAHRSKSSLTL 397
               +  L   +DY  RVYA+  +  G  S P    T     AP  P  PK+   +KSS  L
Sbjct: 10008 YKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADL 10067

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLC-----PAMGYTFRL 451
             +W  P+ D GSK+T Y++E+ E     G  +   G  K  + TKL          Y FR+
Sbjct: 10068 EWSPPLKDGGSKVTGYIVEYKE----EGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRV 10123

Query: 452   AARN--DIGTSGYSQEVVCYTLGNIP---QMPSAPR---LVRAG-----ITWV------T 492
              A N   IG  G   +V+      +    Q+ ++ R   +V AG     I +V      T
Sbjct: 10124 RAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPT 10183

Query: 493   LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN 552
             + W+  E   P+E    T  I                  +  +KN +RS Q  + L A N
Sbjct: 10184 VTWNMNERTLPQEATIETTAISS----------------SMVIKNCQRSHQGVYSLLAKN 10227

Query: 553   TEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT 612
               G+    +  +     D PGP   P +   +T+    + W  P+D+GGS I  Y++E  
Sbjct: 10228 EAGER---KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKR 10284

Query: 613   DGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLS 668
             +  S+   W  V Y+ +    T   L  G  Y  R      I  G   + SE+L +R   
Sbjct: 10285 E--SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPI 10342

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP---- 724
               P +     V    K+  V L W+ P  + G E+  Y   + E   + +E +H      
Sbjct: 10343 TVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINY---VLESRLIGTEKFHKVTNDN 10398

Query: 725   --ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT---- 778
                 + TV  L  G  Y +RV A+N  G G  S  ++       P  CK      T    
Sbjct: 10399 LLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTK-------PITCKDELAPPTLHLD 10451

Query: 779   -PDGCVLVGWESPDSSG--ADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCC 835
               D   +   E+   +G  +   + ++ W +DE  +       D R  I+   PA     
Sbjct: 10452 FRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVL-----EDDRTHIK-TTPATLALE 10505

Query: 836   RLQAFNQAGAGPYSELV---------LCQT-----PASAPDPVSTLCVLEEEPLDAYPDS 881
             +++A  ++ +G Y  +V          CQ      P     PVS            + + 
Sbjct: 10506 KIKA-KRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVS------------FDEV 10552

Query: 882   PSACLVLNWEEPCNN-GSEILAYTIDLGDTSITV--------GNTTMHVMKDLLPETTYR 932
                 +V++W+ P ++ GS+I  Y I+  +    V          TT  V K LL    Y 
Sbjct: 10553 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSK-LLEGKDYI 10611

Query: 933   IRIQAINEIGAGP--FSQFIKAKTR-PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
              RI A N  G      S  +KAK R  +P  P +         S  + W    +K H   
Sbjct: 10612 FRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTW----NKPHDGG 10667

Query: 990   DIVYTLQLEDR---NKRFISIYRGPSHTY---KVQRLTEFTCYSFRIQAASEAGEG---P 1040
               +    LE R   +KR+  + + P H Y   +V  L E   Y FR+ A +E G G   P
Sbjct: 10668 KPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSP 10727

Query: 1041  FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              S+        + P     P       NS ++ W+      G  +  YI++     + E+
Sbjct: 10728 PSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEW 10787

Query: 1100  KQVYKGEEA----TFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             ++     E+     ++++GL+    Y+FRV A    ++ + E   A  P    V  R E
Sbjct: 10788 RRANHTPESCPETKYKVTGLRDGQTYKFRVLA----VNAAGESDPAHVPEPVLVKDRLE 10842



 Score =  135 bits (340), Expect = 2e-31
 Identities = 228/931 (24%), Positives = 358/931 (38%), Gaps = 118/931 (12%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
             K  V ++   +V LSW  P       H G S    Y V +  K  + K+      + L+ 
Sbjct: 16764 KITVDDVTRNSVSLSWTKP------EHDGGSKIIQYIVEMQAKHSE-KWSECARVKSLQA 16816

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL-----AHRSKSSL 395
              + +L    +Y  RV A+  + KG  S+P S      A +    P +     ++  +   
Sbjct: 16817 VITNLTQGEEYLFRVVAV--NEKGR-SDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQ 16873

Query: 396   TLQWKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              L+ + PI    K T   + W +     K+ +              + +     G  + +
Sbjct: 16874 DLKIEVPISGRPKPT---ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16930

Query: 452   AARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYT 510
                N +G    S E+V  TL   P  P  P +        +TL W+ P      ++  Y 
Sbjct: 16931 TVANVVGQKTASIEIV--TLDK-PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYI 16987

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS--CPSEVLVCTTS 568
             ++ ++           T    T  V  LK  T+Y+FR+ A N  G+S    S+ +V    
Sbjct: 16988 VQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 17047

Query: 569   PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS----EANQWEVA 624
                PGPP  P     ++     ++W  P +NGGS ++ Y LE  + NS    + N+  + 
Sbjct: 17048 YKEPGPPGTPFATA-ISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII- 17105

Query: 625   YSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
                  T++   +L+ G  Y+ R      +  G  S+ SE    R     PG   P  V  
Sbjct: 17106 ---HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMV-- 17160

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTV 738
               K  E+ L+W  P  + G  ++ Y VE  +  D   + +   +  E + TV  L     
Sbjct: 17161 --KRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQR 17218

Query: 739   YRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWES----PD 791
             Y FRV A N  G    S  S+ T       + + P IS  P   D  V+   E+     D
Sbjct: 17219 YEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEAD 17276

Query: 792   SSGADISEYRLEW----GEDEESLELIYHGTDTR--FEIRDLL--PAAQYCCRLQAFNQA 843
               G  +    +EW     E EES       TD +    ++D +     QY   L+A N A
Sbjct: 17277 VHGKPLPT--IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI--LRASNVA 17332

Query: 844   GAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEIL 901
             G+  +   V +   P     PV    V  E+              L W  P  +G S+I 
Sbjct: 17333 GSKSFPVNVKVLDRPGPPEGPVQVTGVTSEK------------CSLTWSPPLQDGGSDIS 17380

Query: 902   AYTIDLGDTS-----ITVGNTTMHVMK--DLLPETTYRIRIQAINEIGAG-PFSQFIKAK 953
              Y ++  +TS     +       + +K   LL    Y  RI A+N+ G G P        
Sbjct: 17381 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 17440

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKR 1003
               P  LP  P  LE       S+ + W   +S    +E I Y ++  DR        NKR
Sbjct: 17441 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDG-GSEIIGYIVEKRDRSGIRWIKCNKR 17499

Query: 1004  FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSV----PPTIK 1058
              I+  R      +V  LTE   Y FR+ A + AG G P   T  +     V    PPT  
Sbjct: 17500 RITDLR-----LRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPT-- 17552

Query: 1059  APRVTQLEGNSCEILW-ETVPSMKGDPVNYILQVLVGRESEYKQV--YKGEEAT-FQISG 1114
                +     NS  + W + +     + + Y++++    E E++ V    G   T F+IS 
Sbjct: 17553 NAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK 17612

Query: 1115  LQTNTDYRFRVCACRRC-LDTSQELSGAFSP 1144
             L  + +Y+ RVCA  +  L  +  + G   P
Sbjct: 17613 LTEHQEYKIRVCALNKVGLGEATSVPGTVKP 17643



 Score =  135 bits (340), Expect = 2e-31
 Identities = 181/709 (25%), Positives = 289/709 (40%), Gaps = 74/709 (10%)

Query: 466   VVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
             +   TLG  P  P  P R        V L W  PE     E+  Y++E +E    N    
Sbjct: 21277 ITVITLGP-PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMV 21335

Query: 525   KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP--SEVLVCTTSPDRPGPPTRPLVKG 582
               +    T  V NL +  +Y+FR+ A N  G S P  S ++V       PGPP +P++  
Sbjct: 21336 CSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21395

Query: 583   PVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTL 642
              VTS G S+ WD P  +GGSE+  + +E  + NS   Q       S  EY  T L  G  
Sbjct: 21396 -VTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLD 21454

Query: 643   YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPAS 697
             Y+ R    ++ G S  S+     TL+++P    PP   G P + +V      L+W+ P  
Sbjct: 21455 YQFRVYAENSAGLSSPSDPSKF-TLAVSPVD--PP---GTPDYIDVTRETITLKWNPPLR 21508

Query: 698   ESGCEVSEYSVEMTEPED--VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
             + G ++  YS+E  +  +  V        E + TV  L PG  Y FR+ A N    G  S
Sbjct: 21509 DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARN--AVGTIS 21566

Query: 756   DVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWESPDSS----GADISEYRLEWGEDE 808
               S+ +       +   P +   P   DG ++   ES        G  +   R+ W +D 
Sbjct: 21567 PPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP--RVTWFKDG 21624

Query: 809   ESLE--LIYHGTD----TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ-TPASAP 861
               +E  +    TD    T   +RD     +    ++A N +G+      V  Q TP    
Sbjct: 21625 VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21684

Query: 862   DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVG----- 915
              P+    +  E+            + L W+ P N+G + I  Y I+  +TS         
Sbjct: 21685 GPIRFTNITGEK------------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIED 21732

Query: 916   --NTTMHVMKDLLPETTYRIRIQAINEIGAG-PF-SQFIKAKTR-PLPPLPPRLECAAAG 970
                   +    L+    Y+ R+ A+N+ G G P  S  + A+ +  +P  P   E +   
Sbjct: 21733 KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNIT 21792

Query: 971   PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY--RGPSHT-YKVQRLTEFTCYS 1027
               S+ L W    S   +        + E ++ R++ +   R  S T +KV  LTE   Y 
Sbjct: 21793 GNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYE 21852

Query: 1028  FRIQAASEAGEGPFSETYTFSTTKSV-----PPTIKAPRVTQLEGNSCEILWETVPSMKG 1082
             F + A + AG GP S        +       PPT+   +VT     +  + W + P   G
Sbjct: 21853 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTV--VKVTDTSKTTVSLEW-SKPVFDG 21909

Query: 1083  --DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCA 1127
               + + YI+++      ++ +V      +  + ++ LQ   +Y+FRV A
Sbjct: 21910 GMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 21958



 Score =  133 bits (335), Expect = 9e-31
 Identities = 209/942 (22%), Positives = 351/942 (37%), Gaps = 109/942 (11%)

Query: 243   GIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGL 302
             G++ T R +  +       L+   +  +   D+      P + +++  +V L+W  P   
Sbjct: 13771 GMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKT 13830

Query: 303   SCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362
                P +G    +    +L  K R  K  I       +  +  L    +Y  RV A+  + 
Sbjct: 13831 GGSPITGYHLEFKERNSLLWK-RANKTPI----RMRDFKVTGLTEGLEYEFRVMAINLAG 13885

Query: 363   KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKR 421
              G  S P          + P  P++ + +++S+TL W  P  D G K+T Y++E  +   
Sbjct: 13886 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPS 13945

Query: 422   NSGFR-------QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYT 470
              S  +       +C F       +T L     Y FR+ A+N  G     S  ++ ++C  
Sbjct: 13946 KSWMKANHVNVPECAF------TVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKD 13999

Query: 471   LGNIPQMPSAPRL-----VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPK 525
                 P +   P +     ++AG T V    S      P+   +++   ++    ++    
Sbjct: 14000 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKS--SWSKAGKDIRPSDITQIT 14057

Query: 526   YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
              T      T+K   R    ++ +TA+N  G        V  T  D PGPP  P+    V+
Sbjct: 14058 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH---VKVTVLDVPGPPG-PVEISNVS 14113

Query: 586   SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYK 644
             +   ++ W PP ++GGS I  Y+LE  +  +    W V      +  +  T L  G  Y 
Sbjct: 14114 AEKATLTWTPPLEDGGSPIKSYILEKRE--TSRLLWTVVSEDIQSCRHVATKLIQGNEYI 14171

Query: 645   LRACCISTGGHSQCSESLPVRTLSI--APGQCRPPRVLGRPKHKEVHLEWDVPASESGCE 702
              R   ++  G  +  +S PV+ +     PG    P V    K+    + W  P  + G E
Sbjct: 14172 FRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTAT-VSWKRPVDDGGSE 14230

Query: 703   VSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             ++ Y VE  E +    V +      +L C V  L  G+ Y FRV A N  G GP S+ S+
Sbjct: 14231 ITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASD 14290

Query: 760   ---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLE--------WGED 807
                +  AA PPG    P ++ T      + W  P    G +I+ Y +E        W +D
Sbjct: 14291 SVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKD 14350

Query: 808   EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL 867
                  L      T+F + DL    +Y  R+ A N AG G          PA  PD    +
Sbjct: 14351 TTGTAL----RITQFVVPDLQTKEKYNFRISAINDAGVG---------EPAVIPD----V 14393

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS--ITVGNTTMHVMKDL 925
              ++E E    +         L        G  I  +    G  +  +T     +++    
Sbjct: 14394 EIVEREMAPDFELDAELRRTL----VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRA 14449

Query: 926   LPETTYRIRIQAINEIG--------------AGPFSQFIKAKTRPLPPLPPRLECAAAGP 971
               E T    +  I E                AG  S F+  +    P     L       
Sbjct: 14450 NIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITK 14509

Query: 972   QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH--TYKVQRLTEFTCYSFR 1029
              S+ L W D       +    Y ++  +  ++  S      H  TYKV  L+E   Y FR
Sbjct: 14510 DSVTLHW-DLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 14568

Query: 1030  IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYI 1088
             + A +E G G  +ET         P    +  +  +  ++  + W       G  +  Y+
Sbjct: 14569 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 14628

Query: 1089  LQ-------------VLVGRESEYKQVYKGEEATFQISGLQT 1117
             ++              + G E   + + +GEE TFQ+  + +
Sbjct: 14629 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNS 14670



 Score =  130 bits (327), Expect = 8e-30
 Identities = 183/802 (22%), Positives = 305/802 (38%), Gaps = 105/802 (13%)

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             ++   TL W  P  D G++IT+Y++E  E  R +              +T+L     Y F
Sbjct: 22781 TQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIF 22840

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
             R+ A N  G      S+ +V      IP  P  P  V  G   + +QW+KPE     E+ 
Sbjct: 22841 RVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEIS 22900

Query: 508   TYTLEIQEDENDNL--FHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV--- 562
              Y ++ +E ++      +  Y   D    V +L     Y+FR+TA N  G S PSE    
Sbjct: 22901 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNF 22960

Query: 563   LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
             + C      PGPP+ P V    T H  S+ W  P  +GG++I+ Y+LE+ +   + +QW 
Sbjct: 22961 ISCREPSYTPGPPSAPRVVD-TTKHSISLAWTKPMYDGGTDIVGYVLEMQE--KDTDQWY 23017

Query: 623   VAYSGSA---TEYTFTHLKPGTLYKLRACCISTGGHSQCSESL----PVRTLSIAPGQCR 675
               ++ +    TE+T   LK G  Y  R   ++  G S+ SES+    PV  + I      
Sbjct: 23018 RVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEI------ 23071

Query: 676   PPRVLGRPKHKEVHLEWDVP----ASESG-----CEVSEYSVEMTEPEDVASEVYHGPEL 726
             P   L     K V +          S SG        S+  +++     + +   +   +
Sbjct: 23072 PDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI 23131

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V     G   ++ + A N  G       + +      PG C +  +       V + 
Sbjct: 23132 VDKVNRYDAG---KYTIEAENQSGK---KSATVLVKVYDTPGPCPSVKVKEVSRDSVTIT 23185

Query: 787   WESPD-SSGADISEYRLEWGEDEESLELIYHGTD----TRFEIRDLLPAAQYCCRLQAFN 841
             WE P    GA ++ Y +E  + E ++      T     T + I  L+    Y  R+   N
Sbjct: 23186 WEIPTIDGGAPVNNYIVE--KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPEN 23243

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEI 900
               G G   E       +  P   + L V+         D   + + L WE+P  + GS +
Sbjct: 23244 IYGIGEPCETSDAVLVSEVPLVPAKLEVV---------DVTKSTVTLAWEKPLYDGGSRL 23294

Query: 901   LAYTIDLGDTS-------ITVGNTTM-HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA 952
               Y ++            +T+  T + H +  L     Y  RI+A NE G     + + A
Sbjct: 23295 TGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTA 23354

Query: 953   KT----RPLPPL----------------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV 992
              T    R LP +                P  L    AG       W  + SK   +E + 
Sbjct: 23355 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 23414

Query: 993   YTL--QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
                  ++     R  +I     +T +++ +T  T  + ++    + G             
Sbjct: 23415 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG------------- 23461

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG-EEA 1108
                PPT    ++ +++  S  I WE      G P++ Y+++        +  V +    +
Sbjct: 23462 ---PPTGPI-KIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS 23517

Query: 1109  TFQISGLQTNTDYRFRVCACRR 1130
             TF+ + L    +Y FRV A  R
Sbjct: 23518 TFKFTRLTEGNEYVFRVAATNR 23539



 Score =  130 bits (326), Expect = 1e-29
 Identities = 226/960 (23%), Positives = 367/960 (38%), Gaps = 129/960 (13%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKG-RDGKYKIIYSGEELE 339
             KP V++I   A  +SW  P      P +G    Y     ++ K  R  K  I     +L+
Sbjct: 11337 KPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREVTGKWVRVNKTPIA----DLK 11389

Query: 340   CNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLT 396
               +  L     Y  RV+A      S     S+P+        P  P  PKL  +S+ +  
Sbjct: 11390 FRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD 11449

Query: 397   LQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGY 447
             L W  P+ D GS I  Y++E        W+   ++   RQC F      ++  L     Y
Sbjct: 11450 LVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAF------RVPGLIEGNEY 11503

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---------VRAGITWVTLQWSKP 498
              FR+ A N +G  G  +E+    +      P    L         VR G T   L   K 
Sbjct: 11504 RFRIKAANIVG-EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKG 11562

Query: 499   EGCSPEEVITYTLE----IQEDENDNLFHPKYTGEDLT---CTVKNLKRSTQYKFRLTAS 551
                 PE  IT+T E    ++E   D +       +DL      +K   R+   K+ ++A 
Sbjct: 11563 R---PEPDITWTKEGKVLVREKRVDLI-------QDLPRVELQIKEAVRADHGKYIISAK 11612

Query: 552   NTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEI 611
             N+ G +  S ++      DRPGP     V   VT    ++ W+ P DNGGSEI  +++E 
Sbjct: 11613 NSSGHAQGSAIVNVL---DRPGPCQNLKVTN-VTKENCTISWENPLDNGGSEITNFIVEY 11668

Query: 612   TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES-LPVRTLSIA 670
                N +   W +  S         +L     Y  R C  +  G     E+  P+  ++  
Sbjct: 11669 RKPNQKG--WSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPI 11726

Query: 671   PGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHG--PEL 726
                  P  +    K K  V+L+W  P  + G     Y VE   +  D    V+ G   E 
Sbjct: 11727 DRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11786

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V   +   +Y FRV+  N+GG   +    E+          + P +     G + V 
Sbjct: 11787 HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKE----DLQKPVLDLKLSGVLTVK 11842

Query: 787   WESPDSSGADISEY---RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                     A +       + W +D+++ +L       R +I     ++++   L    ++
Sbjct: 11843 AGDTIRLEAGVRGKPFPEVAWTKDKDATDLT---RSPRVKIDTRADSSKF--SLTKAKRS 11897

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEE-------EPLDAYPDSPSACLVLNWEEPCNN 896
               G Y  +V     A +    +T+ VL++       + +D   D  + C    W+ P ++
Sbjct: 11898 DGGKY--VVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVC----WDPPEDD 11951

Query: 897   GS-EILAYTIDLGDTSITVGNTTMHVMKDLLPETT---------YRIRIQAINEIGAGP- 945
             G  EI  Y ++  +T   V +T    +  L P TT         Y  R++A N+IG GP 
Sbjct: 11952 GGCEIQNYILEKCETKRMVWSTYSATV--LTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 12009

Query: 946   -FSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
               S+ + AKT   +P  P PP  E      + + + W         +    +  + E  +
Sbjct: 12010 TESKPVIAKTKYDKPGRPDPP--EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 12067

Query: 1002  KRFISIYRG--PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV-----P 1054
              R++ + +   P    KVQ L     Y FR++A +E G G  S        K       P
Sbjct: 12068 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGP 12127

Query: 1055  PTIKAPRVTQLEGNSCEILWETVPSMKGDP-VNYILQVL-----VGRESEYKQVYKGEEA 1108
             PT    RV     +S  + W       G P + Y++++         +  +K+     + 
Sbjct: 12128 PT--NFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12185

Query: 1109  T---FQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSL 1164
                 F ++ L  N +Y FRVCA  +  +    EL  A  P    +L+  E+ L   M  L
Sbjct: 12186 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASMRKL 12243



 Score =  129 bits (325), Expect = 1e-29
 Identities = 204/922 (22%), Positives = 356/922 (38%), Gaps = 76/922 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S     +V+ I   +V ++W PP+        G S   +Y V   +  R     
Sbjct: 16657 RVLDTPSPPVNLKVTEITKDSVSITWEPPL------LDGGSKIKNYIVEKREATRKSYAA 16710

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             ++ +  +    +  L+    Y+ RV A      G  ++       +  P+ P    +   
Sbjct: 16711 VVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDV 16770

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W  P  D GSKI  Y++E  + K +  + +C         +T L     Y F
Sbjct: 16771 TRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLF 16829

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVI 507
             R+ A N+ G S      V     ++   P       +    V   L+   P    P+  I
Sbjct: 16830 RVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI 16889

Query: 508   TYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             T+T +    +     +   + +  T ++K   +    ++ +T +N  G+   S  +V   
Sbjct: 16890 TWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL- 16948

Query: 568   SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG 627
               D+P PP  P+    V++   ++ W+PP   GG +I  Y+++  D  +    W+V  + 
Sbjct: 16949 --DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD--TTTTVWDVVSAT 17004

Query: 628   SA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP--- 683
              A T    T LK GT Y+ R    +  G S   ES P+    +A    + P   G P   
Sbjct: 17005 VARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI----VAQYPYKEPGPPGTPFAT 17060

Query: 684   --KHKEVHLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPG 736
                   + ++W  P +  G  V  Y +E  E        V   + H  + +    NL  G
Sbjct: 17061 AISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ--NLEEG 17118

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
               Y FRV A N  G G  S  SE   A  P      P         + + W  P    G+
Sbjct: 17119 IEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGS 17178

Query: 796   DISEYRLEWGE--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELV 852
              I+ Y +E  +  D   ++  +    +T+F +  L    +Y  R+ A N AGA       
Sbjct: 17179 MITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGA------- 17231

Query: 853   LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE----EPCNNGSEILAYTIDLG 908
                 P+ +  P++    +E   +   P      +V   E    E   +G  +       G
Sbjct: 17232 -ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 17290

Query: 909   DTSI------TVGNT---TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
             D  I       + NT    + ++KD +     +  ++A N  G+  F   +K   RP PP
Sbjct: 17291 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17350

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLEDRNKRFISIYRGP--SHTYK 1016
               P ++      +   L W  S        DI  Y ++  + ++   ++      +++ K
Sbjct: 17351 EGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLK 17407

Query: 1017  VQRLTEFTCYSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
             V +L E   Y FRI A ++ G G   E+          +P   K+  VT +  +S  + W
Sbjct: 17408 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 17467

Query: 1075  ETVPSMKG-DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCACRRC 1131
                 S  G + + YI++        + +  K    +   +++GL  + +Y FRV A    
Sbjct: 17468 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA---- 17523

Query: 1132  LDTSQELSGAFSPSAAFVLQRS 1153
                 +  +G   PS A V  ++
Sbjct: 17524 ----ENAAGVGEPSPATVYYKA 17541



 Score =  129 bits (323), Expect = 2e-29
 Identities = 206/920 (22%), Positives = 363/920 (39%), Gaps = 81/920 (8%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EELEC 340
             P+V+ I   ++ + W+ P+       SG      Y +   DK   G +K++     +   
Sbjct: 20700 PEVTKITKNSMTVVWSRPIADGGSDISG------YFLEKRDKKSLGWFKVLKETIRDTRQ 20753

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTL 397
              +  L   +DY  RV A+  + +G  SEP  F   +   + P PP   ++A  +KSS+TL
Sbjct: 20754 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITL 20813

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
              W  P+ D GS +T Y++E  +G+          G  +  +  ++ L P + Y FR++A 
Sbjct: 20814 GWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAV 20873

Query: 455   NDIGTSG---YSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVITY 509
             N  G       ++ V    +   P++     L  + I      +Q   P    P   +T+
Sbjct: 20874 NCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTW 20933

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
               + +   +D  +  + T      T+  + R+   K+ LT  N  G+  P    V     
Sbjct: 20934 RKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE--PKSSTVSVKVL 20991

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV-AYSGS 628
             D P    +  VK  V+    ++ WDPP  +GGS I+ Y++E  D       W V ++  S
Sbjct: 20992 DTPAACQKLQVKH-VSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRT--WSVVSHKCS 21048

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQ-CSESLPVRTLSIAPGQCRPPRVLGRPKHKE 687
             +T +    L   T +  R    +  G  + C  + PV+   + P   R   +    K   
Sbjct: 21049 STSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEV-PAPIRDLSMKDSTK-TS 21106

Query: 688   VHLEWDVPASESGCEVSEYSVEMT-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V L W  P  + G  ++EY VE   + E   S        E  V  L   +V  FRV A 
Sbjct: 21107 VILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAK 21166

Query: 747   NDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGE 806
             N+ G      +  IT         K   I+   D   + G +     G ++       G+
Sbjct: 21167 NEKGLSDPVTIGPITV--------KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGK 21218

Query: 807   DEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPV 864
              + S+  +  G   +    +R      +    ++   +   G Y+ ++L         P+
Sbjct: 21219 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT-VILDNAVCRIAVPI 21277

Query: 865   STLCV----LEEEPLDAYPDSPSACLVLNWEEPCNNGS-EILAYTIDLGDTSIT------ 913
             + + +      + P+  + +  +  ++L+W+ P +NG  EI  Y+I+  +TS T      
Sbjct: 21278 TVITLGPPSKPKGPI-RFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVC 21336

Query: 914   --VGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTR---PLPPLPPRLEC 966
               V  TT  V  +L+ +  Y+ R++A N  G      S  I AK +   P PP  P +  
Sbjct: 21337 SSVARTTFKV-PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21395

Query: 967   AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEF 1023
               +    + L W D+      +E   + ++ ++RN    + ++        Y+   L E 
Sbjct: 21396 VTS--DGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 21452

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
               Y FR+ A + AG    S+   F+   S       P    +   +  + W   P   G 
Sbjct: 21453 LDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP-PLRDGG 21511

Query: 1084  P--VNYILQVLVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
                V Y ++   G E   +  +    E  + ++GL     Y FR+ A        +   G
Sbjct: 21512 SKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA--------RNAVG 21563

Query: 1141  AFSPSAAFVLQRSEVMLTGD 1160
               SP +    Q S +++T D
Sbjct: 21564 TISPPS----QSSGIIMTRD 21579



 Score =  128 bits (322), Expect = 3e-29
 Identities = 231/931 (24%), Positives = 352/931 (37%), Gaps = 155/931 (16%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+ SNI   ++ L+WA P         G S    Y +   +K      K+I      E  
Sbjct: 21786 PEPSNITGNSITLTWARPES------DGGSEIQQYILERREKKSTRWVKVISKRPISETR 21839

Query: 342   LK--DLRPATDYHVRVYAMYNSVKG---------SCSEPVSFTTHSCAPECPFPPKLAHR 390
              K   L    +Y   V A   +  G          C EPV+       P  P   K+   
Sbjct: 21840 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVN------PPGPPTVVKVTDT 21893

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYT 448
             SK++++L+W  P+ D G +I  Y++E  +       +       K    +T L     Y 
Sbjct: 21894 SKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYK 21953

Query: 449   FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGIT-------- 489
             FR++A N  G  G S EV   T+  + ++ +AP L           VRAG +        
Sbjct: 21954 FRVSAINGAG-KGDSCEVTG-TIKAVDRL-TAPELDIDANFKQTHVVRAGASIRLFIAYQ 22010

Query: 490   ---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKF 546
                  T  WSKP+           L ++ D +        T    T TV+N  R+   K+
Sbjct: 22011 GRPTPTAVWSKPDS---------NLSLRADIHT-------TDSFSTLTVENCNRNDAGKY 22054

Query: 547   RLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
              LT  N  G KS    V V     D PGPP  P+    VT    ++ WD P  +GG+ I 
Sbjct: 22055 TLTVENNSGSKSITFTVKVL----DTPGPP-GPITFKDVTRGSATLMWDAPLLDGGARIH 22109

Query: 606   KYLLEITDGNSEANQWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLP 663
              Y++E  + +  +  W+V  S   T   F    L  G  Y  R   ++  G     E   
Sbjct: 22110 HYVVEKREASRRS--WQV-ISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYG---VGEPYE 22163

Query: 664   VRTLSIAPGQCRPPR---VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASE 719
             +    +A  Q  PPR   V+   K   V L W  P  + G  ++ Y +EM +   D   E
Sbjct: 22164 MPEPIVATEQPAPPRRLDVVDTSKSSAV-LAWLKPDHDGGSRITGYLLEMRQKGSDFWVE 22222

Query: 720   VYHGPELECTVGNLLPGTVYRFRVRALNDGGYG-----------------PYSDVSEITT 762
               H  +L  TV  L+  T Y FRV+A ND GY                  P +D++ IT 
Sbjct: 22223 AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN 22282

Query: 763   -----AAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHG 817
                   AG P     P IS  P     V W+        + E RL   ++ + + +    
Sbjct: 22283 QLITCKAGSPFTIDVP-ISGRP--APKVTWK--------LEEMRL---KETDRVSITTTK 22328

Query: 818   TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDA 877
               T   ++D +        L   N AG   +S  V+       P PV+        P++ 
Sbjct: 22329 DRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV---IGRPGPVT-------GPIEV 22378

Query: 878   YPDSPSACLVLNWEEPCN-NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT------ 930
                S  +C VL+W EP +  G+EI  Y ++  ++  T        +K    + T      
Sbjct: 22379 SSVSAESC-VLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYM 22437

Query: 931   -YRIRIQAINEIGAG-PFSQFIKAKTRPL--PPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              Y  R+ + N  G   P          P   P  P R E       ++ ++W +      
Sbjct: 22438 EYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRW-EEPYHDG 22496

Query: 987   AAEDIVYTLQLEDRNK-RFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              ++ I Y ++ ++RN   ++   + P     YKV  L E   Y FR  A + AG    SE
Sbjct: 22497 GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASE 22556

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQ----VLVGRES 1097
                    ++       P VT +  ++  ++W + P+  G    V YI++      VG   
Sbjct: 22557 ASRPIMAQNPVDAPGRPEVTDVTRSTVSLIW-SAPAYDGGSKVVGYIIERKPVSEVGDGR 22615

Query: 1098  EYKQVYK-GEEATFQISGLQTNTDYRFRVCA 1127
               K  Y    +  F ++ L     Y FRV A
Sbjct: 22616 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLA 22646



 Score =  128 bits (321), Expect = 4e-29
 Identities = 204/914 (22%), Positives = 339/914 (37%), Gaps = 102/914 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             +V D  +  +K QV ++    V L W PP+        G S   +Y +   D  +     
Sbjct: 20989 KVLDTPAACQKLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWSV 21042

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---L 387
             + +        L DL   T +  RV A  N +     EP   T    A E P P +   +
Sbjct: 21043 VSHKCSSTSFKLIDLSEKTPFFFRVLAE-NEI--GIGEPCETTEPVKAAEVPAPIRDLSM 21099

Query: 388   AHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
                +K+S+ L W  P  D GS IT Y++E  +GK    +           ++++L     
Sbjct: 21100 KDSTKTSVILSWTKPDFDGGSVITEYVVE-RKGKGEQTWSHAGISKTCEIEVSQLKEQSV 21158

Query: 447   YTFRLAARNDIGTSG-------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPE 499
               FR+ A+N+ G S          +E++     ++  +P A   VR G     +    P 
Sbjct: 21159 LEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHN---VHLELPY 21215

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
                P+  I++  +    +         T   +T ++KN K+    K+ +   N     C 
Sbjct: 21216 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV---CR 21272

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V +   +   P  P  P+    + +    + WD P+DNGG EI  Y +E  +  S+ N
Sbjct: 21273 IAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE-TSQTN 21331

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
                V  S + T +   +L     Y+ R    +  G SQ      V ++ +A  Q R P  
Sbjct: 21332 WKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL----VSSIIVAKHQFRIPGP 21387

Query: 680   LGRPKHKEV-----HLEWDVPASESGCEVSEYSVEMTEP-----EDVASEVYHGPELECT 729
              G+P    V      L WD P  + G EV+ + VE  E      + V +    G E   T
Sbjct: 21388 PGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRAT 21447

Query: 730   VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES 789
                L+ G  Y+FRV A N  G    SD S+ T A  P      P         + + W  
Sbjct: 21448 --GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP 21505

Query: 790   P-DSSGADISEYRLEWGEDEESLEL--IYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAG 846
             P    G+ I  Y +E  +  E          ++ ++ +  L P  +Y  R+ A N  G  
Sbjct: 21506 PLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT- 21564

Query: 847   PYSELVLCQTPASAPDPVSTLCVLEEE---PLDAYPDSPSACLVLNWEEPC--------- 894
                         S P   S + +  +E   P+  +       L++   E           
Sbjct: 21565 -----------ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGR 21613

Query: 895   --------NNGSEI-----LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEI 941
                      +G EI     +  T  LG TS+ V        +D   +      ++A N  
Sbjct: 21614 PVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFV--------RDATRDHRGVYTVEAKNAS 21665

Query: 942   GAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
             G+      +K +  P   + P       G +     W D+      A    Y ++  + +
Sbjct: 21666 GSAKAEIKVKVQDTPGKVVGPIRFTNITGEK--MTLWWDAPLNDGCAPITHYIIEKRETS 21723

Query: 1002  KRFISIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PF-SETYTFSTTKSVPPTI 1057
             +   ++   +  + +Y   +L     Y FR+ A ++ G G P  S+        +VP   
Sbjct: 21724 RLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAP 21783

Query: 1058  KAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG---EEATFQIS 1113
               P  + + GNS  + W    S  G  +  YIL+    + + + +V       E  F+++
Sbjct: 21784 GIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVT 21843

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y F V A
Sbjct: 21844 GLTEGNEYEFHVMA 21857



 Score =  126 bits (317), Expect = 1e-28
 Identities = 220/925 (23%), Positives = 347/925 (37%), Gaps = 120/925 (12%)

Query: 283  QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
            + S+I   +  L+W PP         G +    Y +   + GR     ++    +L   +
Sbjct: 8115 KASDITKSSCKLTWEPP------EFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTV 8168

Query: 343  KDLRPATDYHVRVYAMYNSVKGS----CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
            KDL P  +Y  RV A+ N V G        PV        P+ P   ++ + +  ++T+ 
Sbjct: 8169 KDLIPNGEYFFRVKAV-NKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTIT 8227

Query: 399  WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG------YTFRL 451
            WK P+ D GSKI  Y++E    K    +++C     +H        A G      Y FR+
Sbjct: 8228 WKPPLYDGGSKIMGYIIE-KIAKGEERWKRC----NEHLVPILTYTAKGLEEGKEYQFRV 8282

Query: 452  AARNDIGTSGYSQ--------------EVVCYTLGNIPQMPS-APRLVRAGITWVTLQWS 496
             A N  G S  S+              +V+  T   + +    A     +G  + T+ W 
Sbjct: 8283 RAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWI 8342

Query: 497  KPEG-CSPEEVITYTL--------EIQEDE------NDNLFHPKYTGEDLTCTVKNLKRS 541
            K E    PEE+             E+QE+E         L        +    V++  R 
Sbjct: 8343 KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRP 8402

Query: 542  TQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
                + +   N  G    P  V V     D PGPP    V   +       KW+PP D+G
Sbjct: 8403 DHGLYMIKVENDHGIAKAPCTVSVL----DTPGPPIN-FVFEDIRKTSVLCKWEPPLDDG 8457

Query: 601  GSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
            GSEI+ Y LE  D     ++W V  S     +Y+ T L  G  Y  R    +  G     
Sbjct: 8458 GSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPC 8517

Query: 660  ESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYSVEMTEPE 714
             S P+    +A     PP    +P  ++V      ++W+ P  ++G  +  Y +E  E  
Sbjct: 8518 VSKPL----VAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEP-KDNGSPILGYWLEKREVN 8572

Query: 715  DVA-SEVYHG--PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPG 768
                S V       L+  V  LL G  Y FRV A N  G G +S  S+  TA     PPG
Sbjct: 8573 STHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPG 8632

Query: 769  QCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL--------EWGEDEESLELIYHGTD 819
                P ++ T    + + WE P  + G +I  Y +        EW    E +  +     
Sbjct: 8633 P-PIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKV----- 8686

Query: 820  TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPASAPDPVSTLCVLEEEPLDA 877
             ++ ++++   A Y  R+ A N AG GP  E   V    P   P     + V     + A
Sbjct: 8687 RQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMA 8746

Query: 878  YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTY 931
                    +V     P         +T + G+          VG  +  ++KD L +   
Sbjct: 8747 GKTLRIPAVVTGRPVPTK------VWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHG 8800

Query: 932  RIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
            R  I A N  G+   +  ++    P P L   L+      +   L W D       +E  
Sbjct: 8801 RYVITATNSCGSKFAAARVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPED-DGGSEIT 8857

Query: 992  VYTLQLEDRNKRFISIYRGPSHTYK----VQRLTEFTCYSFRIQAASEAGEGPFSETYTF 1047
             + ++ +D     +  +R P  T +    +  L E   Y FR+ A ++ G GP  E    
Sbjct: 8858 GFIIERKDAK---MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPI 8914

Query: 1048 STTKSVPPTIKAPRVTQLEGNSCEIL--WETVPSMKGDPV-NYILQVLVGRESEYKQVYK 1104
                 + P     R+T  E     I   W+   S  G P+  YI++     + ++++V K
Sbjct: 8915 LAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNK 8974

Query: 1105 G--EEATFQISGLQTNTDYRFRVCA 1127
                  +F +  L  +  Y FRV A
Sbjct: 8975 RLCPTTSFLVENLDEHQMYEFRVKA 8999



 Score =  126 bits (316), Expect = 1e-28
 Identities = 195/799 (24%), Positives = 300/799 (37%), Gaps = 105/799 (13%)

Query: 391   SKSSLTLQWKAPIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +K  + + WK P+D+ GSKITNY++E  E  ++         ++  CK++KL     Y F
Sbjct: 10553 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIF 10612

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKP-EGCSPEEV 506
             R+ A N  G S    S  +       +P  P  P +         + W+KP +G  P  +
Sbjct: 10613 RIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP--I 10670

Query: 507   ITYTLEIQEDEN-------DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG---K 556
               Y LE +E  +        +  HP YT       V +L    QY+FR++A N  G    
Sbjct: 10671 TNYILEKRETMSKRWARVTKDPIHP-YT----KFRVPDLLEGCQYEFRVSAENEIGIGDP 10725

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
             S PS+ +       +P PP  P      T +   + W PP+ +GGS+IL Y++E      
Sbjct: 10726 SPPSKPVFAKDPIAKPSPPVNPEAI-DTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10784

Query: 617   EANQWEVA----YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPG 672
             E  +W  A     S   T+Y  T L+ G  YK R   ++  G    S+   V    +   
Sbjct: 10785 E--EWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKD 10839

Query: 673   QCRPPRV-----LGRPKHKEVHLEWDVPASESGC---EVSEYSVEMTEPEDVASEVYH-G 723
             +  PP +     + R +H +V     + A   G    +V+    +   P     +V   G
Sbjct: 10840 RLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVG 10899

Query: 724   PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCV 783
              +LE        G +Y   V   N  G    S    +    GPP   +   I    D C 
Sbjct: 10900 SKLEIRNAAHEDGGIYSLTVE--NPAGSKTVSVKVLVLDKPGPPRDLEVSEI--RKDSCY 10955

Query: 784   LVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFN 841
             L   E  D  G+ I+ Y +E  +   +       T  +     + L    QY  R+ A N
Sbjct: 10956 LTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAEN 11015

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEE--EPLDA-YPDSPSACLVLNWEEP-CNNG 897
             Q G GP+ E          P P+  L  L     P D  + D     + L W +P  + G
Sbjct: 11016 QYGRGPFVE---------TPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGG 11066

Query: 898   SEILAYTIDLGDTSI-------TVGNTTMHVMKDLLPETTYRIRIQAINEIGAG-PFSQF 949
             S I  Y ++  +          TV N    V+  L    TYR R++A N +G G P +  
Sbjct: 11067 SPITGYLVEYQEEGTQDWIKFKTVTNLEC-VVTGLQQGKTYRFRVKAENIVGLGLPDTTI 11125

Query: 950   -IKAKTRPLPP-----------------LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
              I+ + + +PP                    R      G      KW    S+    E  
Sbjct: 11126 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEH- 11184

Query: 992   VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK 1051
              YT++ ++            S    ++         ++I  ++ AG           T  
Sbjct: 11185 -YTVETDNF-----------SSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVL 11229

Query: 1052  SVPPTIKAP-RVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
              VP     P  +  +      I W+      G PV NYI++    R+  +  V  G   T
Sbjct: 11230 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11289

Query: 1110  -FQISGLQTNTDYRFRVCA 1127
               +I  LQ   +Y FRV A
Sbjct: 11290 KLKIPHLQKGCEYVFRVRA 11308



 Score =  125 bits (315), Expect = 2e-28
 Identities = 151/597 (25%), Positives = 233/597 (39%), Gaps = 48/597 (8%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS I+  +  L+W  P+        G S   +Y V   D        +  + ++     
Sbjct: 10945 EVSEIRKDSCYLTWKEPLD------DGGSVITNYVVERRDVASAQWSPLSATSKKKSHFA 10998

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR---SKSSLTLQW 399
             K L     Y  RV A     +G   E             P PPK  H     K+ ++L W
Sbjct: 10999 KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVW 11058

Query: 400   KAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
               P  D GS IT YL+E+ E +    + +    +   C +T L     Y FR+ A N +G
Sbjct: 11059 NKPDRDGGSPITGYLVEYQE-EGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVG 11117

Query: 459   TS--GYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCSPEEVITYTLEIQ 514
                   +  + C      P +    +L+   +     T+++       P     +T +  
Sbjct: 11118 LGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGS 11177

Query: 515   EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGP 574
             E + D  +  +        T+KN  R    ++++T SN  G      V V  T  D PGP
Sbjct: 11178 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKT---VAVHLTVLDVPGP 11234

Query: 575   PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA-TEYT 633
             PT P+    VT    ++ W PPKD+GGS ++ Y++E  D  +  + W V  SGS+ T+  
Sbjct: 11235 PTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQD--TRKDTWGVVSSGSSKTKLK 11292

Query: 634   FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV----- 688
               HL+ G  Y  R    +  G     +S P    ++A  +  PP   G+P   ++     
Sbjct: 11293 IPHLQKGCEYVFRVRAENKIGVGPPLDSTP----TVAKHKFSPPSPPGKPVVTDITENAA 11348

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP--ELECTVGNLLPGTVYRFRVRAL 746
              + W +P S+ G  ++ Y +E  E       V   P  +L+  V  L  G  Y FRV A 
Sbjct: 11349 TVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 11408

Query: 747   NDGGY---GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRL 802
             N  G     P SD  +      PPG    P +         + W  P    G+ I  Y +
Sbjct: 11409 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVV 11468

Query: 803   E--------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL 851
             E        W    +  ELI       F +  L+   +Y  R++A N  G G   EL
Sbjct: 11469 ECQKPGTAQWNRINKD-ELI---RQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 11521



 Score =  125 bits (313), Expect = 3e-28
 Identities = 187/810 (23%), Positives = 304/810 (37%), Gaps = 46/810 (5%)

Query: 351   YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKI 409
             + VR    Y       SEP+        P  P  P+     K  + +QW  P  D G++I
Sbjct: 22840 FRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEI 22899

Query: 410   TNYLLEWDEGK--RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQE-- 465
             +NYL++  E K  R +   + +       K+T L     Y FR+ A N  G S  S+   
Sbjct: 22900 SNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASN 22959

Query: 466   -VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLF-- 522
              + C      P  PSAPR+V      ++L W+KP      +++ Y LE+QE + D  +  
Sbjct: 22960 FISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRV 23019

Query: 523   HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPL--- 579
             H   T  +   TV +LK   +Y FR+ A N +G S  SE +      +R   P   L   
Sbjct: 23020 HTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADD 23079

Query: 580   VKGPVTSH-GFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
             +K  VT   G S++           ++ +  +  D  S A         +   Y+   + 
Sbjct: 23080 LKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA------IIDTTESYSLLIVD 23133

Query: 639   PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
                 Y      I     S    +  +  +   PG C P   +       V + W++P  +
Sbjct: 23134 KVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPC-PSVKVKEVSRDSVTITWEIPTID 23192

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGP 753
              G  V+ Y VE  E    A   +     +C+     +  L+ GT+Y FRV   N  G G 
Sbjct: 23193 GGAPVNNYIVEKRE---AAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE 23249

Query: 754   YSDVSE-ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEW---GEDE 808
               + S+ +  +  P    K   +  T    V + WE P    G+ ++ Y LE    G + 
Sbjct: 23250 PCETSDAVLVSEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGTER 23308

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPD-PVSTL 867
                 +    T     +  L    QY  R++A N+ G     E V   T       P   L
Sbjct: 23309 WMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDL 23368

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLP 927
               + ++ +      P   ++     P    S   A +       +TV  T   V K  + 
Sbjct: 23369 STMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTV-ETHTKVAKLTIR 23427

Query: 928   ETTYRIRIQAINEIG--AGPFSQFIKA--KTRPLPPLPPRLECAAAGPQSLKLKWGDSNS 983
             ETT R   +   E+    G  S+ IK     +P PP  P ++       S+ + W     
Sbjct: 23428 ETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEIDATSITISWEPPEL 23486

Query: 984   KTHAAEDIVYTLQLEDRNKRFISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPF- 1041
                A        Q +     ++ +    +  T+K  RLTE   Y FR+ A +  G G + 
Sbjct: 23487 DGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYL 23546

Query: 1042  -SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              SE     ++  +P   +  ++  +  +   + W       G  V  YI++    R   +
Sbjct: 23547 QSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23606

Query: 1100  KQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
              +V K       ++ +GL    +Y  RV A
Sbjct: 23607 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTA 23636



 Score =  122 bits (307), Expect = 2e-27
 Identities = 153/606 (25%), Positives = 230/606 (37%), Gaps = 68/606 (11%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             + P PP+   +    K S  L W+ PI D G+K+ NY+++  E  R +        S+  
Sbjct: 17742 DTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTS 17801

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW 495
              K+  L     Y FR+ A N+ G     + V        P  P    L     T  +L W
Sbjct: 17802 FKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMW 17861

Query: 496   SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
              KPE      V+ Y +E+Q    +         E   C   V  L    +Y+FR+ A N 
Sbjct: 17862 EKPEHDGGSRVLGYVVEMQPKGTEKW---SIVAESKVCNAVVTGLSSGQEYQFRVKAYNE 17918

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVKWDPPKDNGGSEILKYLL 609
             +GKS P  + V   + D      +P +K P  ++    G  +K + P        + +  
Sbjct: 17919 KGKSDPRVLGVPVIAKDLT---IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISW-- 17973

Query: 610   EITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS-TGGHSQCSESLPVRTLS 668
              + DG        V    +AT  T  H+K G         ++ T      +E+L V  L 
Sbjct: 17974 -VKDGEPLKQTTRVNVEETATS-TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 18031

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC 728
               PG    P          V + W+ PA   GC++S Y VE  +       +        
Sbjct: 18032 -KPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVART 18090

Query: 729   TVG--NLLPGTVYRFRVRALNDGGYGPYSDVSEITTA-----AGPPGQCKAPCISCTPDG 781
             T+    L  GT Y+FR+ A N  G     D   +         GPPG    P ++     
Sbjct: 18091 TIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPG---TPFVTSISKD 18147

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRL 837
              +LV W  P +  G  I  Y LE  E    L +  + T   DT+F+   L    +Y  ++
Sbjct: 18148 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18207

Query: 838   QAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV------LNWE 891
              A N  G G              P  VS  C +  +P D  P  P A ++      L W+
Sbjct: 18208 SAENIVGIG-------------KPSKVSE-CFVARDPCDP-PGRPEAIVITRNNVTLKWK 18252

Query: 892   EPC-NNGSEILAYTIDLGD--------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
             +P  + GS+I  Y ++  D         S T    T   +  L+ +  Y  R+ A N   
Sbjct: 18253 KPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARN--A 18310

Query: 943   AGPFSQ 948
             AG FS+
Sbjct: 18311 AGNFSE 18316



 Score =  121 bits (304), Expect = 3e-27
 Identities = 199/899 (22%), Positives = 328/899 (36%), Gaps = 99/899 (11%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+ + A    L+W PP+        G +    Y +   +  R    ++    + L   +
Sbjct: 18438 KVTGVTAEKCYLAWNPPL------QDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKV 18491

Query: 343   KDLRPATDYHVRVYAM--YNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L P  +Y  RV A+  Y   +   S PV+       P  P  P+++  +K S+ + W 
Sbjct: 18492 TKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWA 18551

Query: 401   APIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPAMGYTFRLAARNDI 457
              P+D+ G++I  Y+LE    K    + +C   +    +L  T L     Y FR+AA N  
Sbjct: 18552 RPVDDGGTEIEGYILE-KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAA 18610

Query: 458   GTSGYSQEVVCYTLGNI---PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
             G    S+  V Y   +    P  PS P++     + V+L WSKP       V  Y +E++
Sbjct: 18611 GVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVK 18670

Query: 515   EDEND--NLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
             E   D      P    +    TV  LK +T+Y FR+ A N+EG   P+ +     + +R 
Sbjct: 18671 EAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERI 18730

Query: 573   GPPTRPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
              PP   L   ++  V                 S  L+  + I        +WE A  G  
Sbjct: 18731 EPPEIELDADLRKVVVLR-------------ASATLRLFVTIKGRPEPEVKWEKA-EGIL 18776

Query: 630   TE-------YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             T+        +FT L    + +  +   +    +          + +      P  +  R
Sbjct: 18777 TDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR 18836

Query: 683   PKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPG 736
                K+ V L W+ P  + G +++ Y VE  E      + Y      CT     + NL  G
Sbjct: 18837 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRE---TTRKAYATITNNCTKTTFRIENLQEG 18893

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS-SGA 795
               Y FRV A N+ G G  ++ +E    + PP       +         + WE P+S  G+
Sbjct: 18894 CSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGS 18953

Query: 796   DISEYRLEW-GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVL- 853
              I+ Y +E   +  E              I  L    +Y  R+ A N+ G     +L + 
Sbjct: 18954 KITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVP 19013

Query: 854   -----CQTPASAPDPVSTLCVLEEEPLD---AYPDSPSACLVLNWEEPCNNGSEILAYTI 905
                   +   S   P  T  V   E L     +   P A   +NW +      E     +
Sbjct: 19014 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQA--TVNWRKDGQTLKETTRVNV 19071

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                 T       T   +K+   E      +   N  G+      I    RP PP P R++
Sbjct: 19072 SSSKT------VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRID 19125

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFT 1024
               +    S+ + W                 + E  +  +  + +  + T  K+ RLT  +
Sbjct: 19126 EVSC--DSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGS 19183

Query: 1025  CYSFRIQAASEAGEGPFSET------YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
              Y FR+ A +  G+  +SE+      Y FS     P     P+V     ++  + W+   
Sbjct: 19184 EYQFRVCAENRYGKSSYSESSAVVAEYPFSP----PGPPGTPKVVHATKSTMLVTWQV-- 19237

Query: 1079  SMKGDPVNYILQVLVGRESEYKQ----------VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  PVN     ++G   EYK+               +   ++SGL     Y +RV A
Sbjct: 19238 -----PVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYA 19291



 Score =  119 bits (298), Expect = 2e-26
 Identities = 205/920 (22%), Positives = 336/920 (36%), Gaps = 106/920 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D    +   +VS++   +  +SWAPP       + G S    Y V   +  R     
Sbjct: 12322 RVLDTPGPVSDLKVSDVTKTSCHVSWAPP------ENDGGSQVTHYIVEKREADRKTWST 12375

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKL 387
             +    ++   ++ +L P  +Y+ RV A+      V     +PV  +     P+ P   ++
Sbjct: 12376 VTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEV 12435

Query: 388   AHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPA 444
                +K+S TL W  P+ D G+KI  Y+  + E ++ +  R   +   K   L  T L   
Sbjct: 12436 TEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPAD-RWTEYSVVKDLSLVVTGLKEG 12494

Query: 445   MGYTFRLAARNDIGTSGYSQEVVCYTLGN--IPQMPSAPRLVRA-------------GIT 489
               Y FR+AARN +G S   +    Y      +P     P  +               G  
Sbjct: 12495 KKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKP 12554

Query: 490   WVTLQWSKPEGCSPEEVITYT-LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRL 548
               T +W K E    +EV+T + L + + ++ ++             +K++ R     + L
Sbjct: 12555 HPTCKWKKGE----DEVVTSSHLAVHKADSSSIL-----------IIKDVTRKDSGYYSL 12599

Query: 549   TASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYL 608
             TA N+ G       +V     D PGPP  P     + +   S+ W  P ++GGS I  Y+
Sbjct: 12600 TAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYI 12656

Query: 609   LEITDGNSEANQWEVAY-SGSATEYTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVR 665
             +E  D       W  A  S + T      L PG  Y  R    +  G S+   S  +  +
Sbjct: 12657 VEKCD--VSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQ 12714

Query: 666   TLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-----SEV 720
                  P + +  RV  +     + + WD P S+ G  +  Y +E  E   +        +
Sbjct: 12715 FPFGVPSEPKNARVT-KVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL 12773

Query: 721   YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISC 777
                 E  C    L+ G  Y FR+ ALN  G  P S  +E  TA     PPG  K   I  
Sbjct: 12774 VRSTEYPC--AGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPG--KPEVIDV 12829

Query: 778   TPDGCVLVGWESPDSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLP 829
             T     L+        G+ I  Y +E        W     +   I       +    L  
Sbjct: 12830 TKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEE 12886

Query: 830   AAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN 889
              AQY  R  A       P         P+   DPV+ L       +D      S   V  
Sbjct: 12887 KAQYQFRAIARTAVNISP---------PSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 12937

Query: 890   WEEPCNNGS------EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR--------I 935
                 C + +        +++  D G          M + ++L     + +         I
Sbjct: 12938 GTNVCLDATVFGKPMPTVSWKKD-GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTI 12996

Query: 936   QAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
              A N  G+   +  +K   +P PP   ++    +    L  +    +  +     IV   
Sbjct: 12997 TAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKR 13056

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
             +    N   +S    P  +  V++L E   Y FRI A ++ G G   F+E          
Sbjct: 13057 ETSRPNWAQVSA-TVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDP 13115

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGE--EATF 1110
             P     P ++ +  +   + W+      G P+  Y+L+    +   + +V +    E T 
Sbjct: 13116 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTL 13175

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             + +GLQ  T+Y FRV A  +
Sbjct: 13176 KATGLQEGTEYEFRVTAINK 13195



 Score =  118 bits (295), Expect = 4e-26
 Identities = 187/845 (22%), Positives = 322/845 (38%), Gaps = 110/845 (13%)

Query: 351  YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKI 409
            Y ++V   +   K  C+  V  T     P  P         K+S+  +W+ P+D+G S+I
Sbjct: 8407 YMIKVENDHGIAKAPCTVSVLDT-----PGPPINFVFEDIRKTSVLCKWEPPLDDGGSEI 8461

Query: 410  TNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTSG--YSQE 465
             NY LE  +  +          + +HCK  +TKL     Y FR+ A N  G      S+ 
Sbjct: 8462 INYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP 8521

Query: 466  VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP- 524
            +V       P  P  P +       + ++W++P+  +   ++ Y LE +E  + +     
Sbjct: 8522 LVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLEKREVNSTHWSRVN 8580

Query: 525  KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVK 581
            K     L   V  L     Y FR+ A N  G    S PS+          PGPP   +  
Sbjct: 8581 KSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTD 8640

Query: 582  GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP 639
               T+    ++W+PP  NGG EI+ Y ++     +  N+W           +YT   ++ 
Sbjct: 8641 TSSTT--IELEWEPPAFNGGGEIVGYFVDKQLVGT--NEWSRCTEKMIKVRQYTVKEIRE 8696

Query: 640  GTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHL----EWDVP 695
            G  YKLR   ++  G     E+ PV   ++A  Q  P   L       + +       +P
Sbjct: 8697 GADYKLRVSAVNAAGEGPPGETQPV---TVAEPQEPPAVELDVSVKGGIQIMAGKTLRIP 8753

Query: 696  ASESGCEV-----SEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
            A  +G  V     ++   E+ +   V   V  G + E  + + L     R+ + A N  G
Sbjct: 8754 AVVTGRPVPTKVWTKEEGELDKDRVVIDNV--GTKSELIIKDALRKDHGRYVITATNSCG 8811

Query: 751  YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE------ 803
                +   E+    GP    K P +  T     L+ W  P D  G++I+ + +E      
Sbjct: 8812 SKFAAARVEVFDVPGPVLDLK-PVV--TNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 8868

Query: 804  --WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPAS 859
              W +  E+         ++ +I  LL   +Y  R+ A N+ G GP  E+  +L   P  
Sbjct: 8869 HTWRQPIETER-------SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 8921

Query: 860  APDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTI--------DLGDT 910
             P     L          Y +   + + L+W+EP  N GS I  Y I        D    
Sbjct: 8922 PPTSPERL---------TYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERV 8972

Query: 911  SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA--KTRPLPPL-------- 960
            +  +  TT  ++++L     Y  R++A+NEIG    S  +    +   +PP         
Sbjct: 8973 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVR 9032

Query: 961  ----------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
                      P  +     G    K++W  + +      D +   + E        + R 
Sbjct: 9033 GDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE--------VSRS 9084

Query: 1011 PSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
             + T   + +       ++ + A++  G   F   +     +  PP   A  VT ++  S
Sbjct: 9085 EAKTELSIPKAVREDKGTYTVTASNRLG-SVFRNVHVEVYDRPSPPRNLA--VTDIKAES 9141

Query: 1070 CEILWETVPSMKGDPVNYIL---QVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRV 1125
            C + W+      G  + + +   +    +++E+++V     E  + I  L  N  Y FRV
Sbjct: 9142 CYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRV 9201

Query: 1126 CACRR 1130
             A  +
Sbjct: 9202 RAVNK 9206



 Score =  118 bits (295), Expect = 4e-26
 Identities = 181/757 (23%), Positives = 289/757 (38%), Gaps = 115/757 (15%)

Query: 378   APECPFPP-KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             AP  P PP  ++     + +L W  P+ D GS ITNY++E  +  R          ++  
Sbjct: 12619 APGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTS 12678

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
             C++ KL P   Y FR+ A N  G S    S ++V      +P  P   R+ +     + +
Sbjct: 12679 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFV 12738

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTA 550
              W +P+      +I Y +E    E ++L   K     +  T      L    +Y FR+ A
Sbjct: 12739 AWDRPDSDGGSPIIGYLIE--RKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYA 12796

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G S PS+     T+     PP +P V   VT    S+ W  PK +GGS+I+ Y +E
Sbjct: 12797 LNKAGSSPPSKPTEYVTARMPVDPPGKPEVI-DVTKSTVSLIWARPKHDGGSKIIGYFVE 12855

Query: 611   I--TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTL 667
                  G+         +     EYT T L+    Y+ RA   +    S  SE S PV  L
Sbjct: 12856 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12915

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE 727
             +    +  PPR+      K       +   ++G  V   +    +P    S    G  L+
Sbjct: 12916 A----ENVPPRIDLSVAMK------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 12965

Query: 728   CTVG-------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA----------GPPGQC 770
                G       NL   T+  F V   + G Y   ++ S  + +A          GPP   
Sbjct: 12966 PAEGIKMAMQRNLC--TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASV 13023

Query: 771   KAPCISCTPDGCVLVGWESP-DSSGADISEY--------RLEWGEDEESLELIYHGTDTR 821
             K   I+       ++ WE P +  G++I+ Y        R  W +   ++ +      T 
Sbjct: 13024 K---INKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI------TS 13074

Query: 822   FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDS 881
               +  L+   +Y  R+ A N+ G G               DPV T   + + P     D 
Sbjct: 13075 CSVEKLIEGHEYQFRICAENKYGVG---------------DPVFTEPAIAKNPY----DP 13115

Query: 882   PSAC------------LVLNWEEPCNN-GSEILAYTIDLGDTSITVGNTTMHVMKDLLPE 928
             P  C            + ++W+ P ++ GS I  Y ++  +T     N T    K ++  
Sbjct: 13116 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV--NWTKVNRKPIIER 13173

Query: 929   ----------TTYRIRIQAINEIGAGPFSQFIK---AKTRPLPPLPPRL-ECAAAGPQSL 974
                       T Y  R+ AIN+ G G  S   K   A+    PP PP   +       S+
Sbjct: 13174 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13233

Query: 975   KLKWGDS--NSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQ 1031
              L WG    +  +     +V   + +  N    ++ +    T ++V  L E T Y FR+ 
Sbjct: 13234 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 13293

Query: 1032  AASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGN 1068
             A ++ G    S+       K  P  I  P   +L+ +
Sbjct: 13294 AVNKIGYSDPSDV----PDKHYPKDILIPPEGELDAD 13326



 Score =  118 bits (295), Expect = 4e-26
 Identities = 173/749 (23%), Positives = 277/749 (36%), Gaps = 83/749 (11%)

Query: 433   QKHCKLTKLCPAMGYTFRLAARNDIG--------TSGYSQEVVCYTLGNIPQMPSAP-RL 483
             + H K+ KL      T R     D G         +G + E +   + + P  P+ P ++
Sbjct: 23416 ETHTKVAKL------TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI 23469

Query: 484   VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQ 543
                  T +T+ W  PE      +  Y +E ++           +    T     L    +
Sbjct: 23470 DEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNE 23529

Query: 544   YKFRLTASNTEG--KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y FR+ A+N  G      SEV+ C +S   PGPP   L    V+  G ++ W PP+D+GG
Sbjct: 23530 YVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPP-ETLQIFDVSRDGMTLTWYPPEDDGG 23588

Query: 602   SEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE- 660
             S++  Y++E  +  ++          + T Y  T L  G  Y+ R   I+  G  + S  
Sbjct: 23589 SQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRP 23648

Query: 661   SLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED--- 715
             S P+  +     PG+ + PRV    +   V L W VP  E G +V+ Y +EM + +    
Sbjct: 23649 SKPIVAMDPIAPPGKPQNPRVTDTTR-TSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEW 23707

Query: 716   VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCI 775
                        E T+ +L  G  YRFRV A N GG G  ++V         PG  K   +
Sbjct: 23708 TKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEV---------PGTVKVTEM 23758

Query: 776   SCTPD---------------GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDT 820
                PD               G V+            I ++  E  +  +   +    T T
Sbjct: 23759 LEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHT 23818

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGA-GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYP 879
                I++          L   N+ G    Y ++ +  +P S   P+             Y 
Sbjct: 23819 ELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLE------------YD 23866

Query: 880   DSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVGNT-------TMHVMKDLLPETTY 931
             D     + ++W  P ++G ++IL Y ++  +       T       T  V+K L     Y
Sbjct: 23867 DIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEY 23926

Query: 932   RIRIQAINEIGAGP---FSQFIKAKTRPLPPLPPRL--ECAAAGPQSLKLKWGDSNSKTH 986
               R+ A N+ G        + +  KT   PP PP    E       S+ L W        
Sbjct: 23927 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGG 23986

Query: 987   AAEDIVYTLQLEDRNKRFISIYRGPSHT--YKVQRLTEFTCYSFRIQAASEAG---EGPF 1041
             +     Y  + E    +++   +    T  Y V  L     Y FRI A ++ G     P 
Sbjct: 23987 SRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPA 24046

Query: 1042  SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYK 1100
             SE          P       +  +  +S  + WE      G  +  Y ++     +S +K
Sbjct: 24047 SEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWK 24106

Query: 1101  QVYKG--EEATFQISGLQTNTDYRFRVCA 1127
             +  K   ++  F I GL   T+Y FRV A
Sbjct: 24107 KSNKERIKDKQFTIGGLLEATEYEFRVFA 24135



 Score =  117 bits (292), Expect = 9e-26
 Identities = 190/802 (23%), Positives = 298/802 (37%), Gaps = 63/802 (7%)

Query: 368   EPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNS 423
             EP   T    A E P PP    +   +KS+++L W  P  D GSKIT Y++E  + K + 
Sbjct: 14579 EPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIE-AQRKGSD 14637

Query: 424   GFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAP 481
              +          C +  L     YTF++ A N  G S    S+ V+      +P++    
Sbjct: 14638 QWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRG 14697

Query: 482   RLVRAGITWV--TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLK 539
                +  I      ++   P    P+  +T+    Q  +     + + T       +    
Sbjct: 14698 IYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECV 14757

Query: 540   RSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDN 599
             RS    + LTA N  G+    +V+      D PGPPT P+    V+S   +  WDPP+++
Sbjct: 14758 RSDSGPYPLTARNIVGEV--GDVITIQVH-DIPGPPTGPIKFDEVSSDFVTFSWDPPEND 14814

Query: 600   GGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC-----ISTG 653
             GG  I  Y++E+    +++  W E+A +   T Y  T L  G  Y+ R        +  G
Sbjct: 14815 GGVPISNYVVEMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPG 14872

Query: 654   GHSQC-SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE 712
               S C   + P +     PG    P+V    K   + + W  P S+ G  +  Y VE  E
Sbjct: 14873 ITSACIVANYPFK----VPGPPGTPQVTAVTK-DSMTISWHEPLSDGGSPILGYHVERKE 14927

Query: 713   PEDVASEVYHGPELECTV---GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQ 769
                +  +      +   +     L  G  Y FRV A N  G    S  SE   A  P   
Sbjct: 14928 RNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDP 14987

Query: 770   CKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL---IYHGTDTRFEIR 825
                P         V + W  P+ + G  I+ Y +E  +      L     +  +  F + 
Sbjct: 14988 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 15047

Query: 826   DLLPAAQYCCRLQAFNQAGA----GPYSELVLCQTPASAPDP------VSTLCVLEEEPL 875
              L   A Y  R+ A N AGA       S+ + C+    AP          T+ +   E  
Sbjct: 15048 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAF 15107

Query: 876   DAYPD-SPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR 934
                 D S      + W +            I + D S  + N      KD     +    
Sbjct: 15108 RLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVN------KDSTRRDSGAYT 15161

Query: 935   IQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
             + A N  G       +K   RP PP  P L       +   L W        A  D    
Sbjct: 15162 LTATNPGGFAKHIFNVKVLDRPGPPEGP-LAVTEVTSEKCVLSWFPPLDDGGAKIDHYIV 15220

Query: 995   LQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
              + E     + ++      T  KV +L +   Y FR+ A ++ G G P       +    
Sbjct: 15221 QKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPY 15280

Query: 1053  VPP-TIKAPRVTQLEGNSCEILWETVPSMKG-DPVNYILQVLVGRESEYKQVYKGEEAT- 1109
              PP   K P VT +  +S  + W    S  G + +NYI++    R+   ++  K  + T 
Sbjct: 15281 GPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVE---RRDKAGQRWIKCNKKTL 15337

Query: 1110  ----FQISGLQTNTDYRFRVCA 1127
                 +++SGL    +Y FR+ A
Sbjct: 15338 TDLRYKVSGLTEGHEYEFRIMA 15359



 Score =  117 bits (292), Expect = 9e-26
 Identities = 209/903 (23%), Positives = 342/903 (37%), Gaps = 101/903 (11%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             PQV+ +   ++ +SW  P+     P  G      Y V    K R+G      S   +  N
Sbjct: 14893 PQVTAVTKDSMTISWHEPLSDGGSPILG------YHV--ERKERNGILWQTVSKALVPGN 14944

Query: 342   LKDLRPATD---YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +      TD   Y  RV A   + K   S+P          + P  P   + ++ ++TL+
Sbjct: 14945 IFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLK 15004

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRLAARND 456
             W  P    G KIT+Y++E  +       +  F    +    ++ L     Y FR+ A+N 
Sbjct: 15005 WAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNA 15064

Query: 457   IGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITW-----------VTLQWS 496
              G     S  S  + C      P++    +     +++AG  +            T++WS
Sbjct: 15065 AGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS 15124

Query: 497   KPEGCSPEEVITYTLEIQ-EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
             K      E   T  LEI+  D + NL +            K+  R     + LTA+N  G
Sbjct: 15125 KD---GKELEGTAKLEIKIADFSTNLVN------------KDSTRRDSGAYTLTATNPGG 15169

Query: 556   KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
              +   + +      DRPGPP  PL    VTS    + W PP D+GG++I  Y+++  +  
Sbjct: 15170 FA---KHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRE-T 15225

Query: 616   SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQ 673
             S      VA     T+   T L  G  Y  R   ++  G  +  ES PV  ++    P  
Sbjct: 15226 SRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDP 15285

Query: 674   CRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTV 730
              + P V    K   V + W  P S+ G E+  Y VE  +      +        +L   V
Sbjct: 15286 PKNPEVTTITKDSMV-VCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKV 15344

Query: 731   GNLLPGTVYRFRVRALNDGGY------GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVL 784
               L  G  Y FR+ A N  G        P+    +     GPPG    P +  T    + 
Sbjct: 15345 SGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSIS 15401

Query: 785   VGWESP-DSSGADISEYRLEWG---EDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQA 839
             + W  P    G++I+ Y +E     EDE  +     G   T + I  L    +Y  R+ A
Sbjct: 15402 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15461

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSE 899
              N  G G   E  L      A D +    +  +  L       + C +  +       + 
Sbjct: 15462 MNSEGLG---EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAP 15518

Query: 900   ILAYTIDLGDT--SITVGNTTMHVMKDLLPETTYRI---RIQAINEIGAGPFSQFIKAKT 954
              + +  D G++    ++ +T+ + +  L+     R    +     E  +G  S F+  + 
Sbjct: 15519 EVKWARDHGESLDKASIESTSSYTL--LIVGNVNRFDSGKYILTVENSSGSKSAFVNVRV 15576

Query: 955   RPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
                P  P  L+       S+ L W      G S  K +  E      + E   K + ++ 
Sbjct: 15577 LDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE------KRESTRKAYSTVA 15630

Query: 1009  RGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE- 1066
                  T +KV +L E   Y FR+ A +E G G  +E  T  + K+    +   ++T ++ 
Sbjct: 15631 TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE--TAESVKASERPLPPGKITLMDV 15688

Query: 1067  -GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFR 1124
               NS  + WE      G  +  YI+++      ++      +     I+GL    +Y FR
Sbjct: 15689 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFR 15748

Query: 1125  VCA 1127
             V A
Sbjct: 15749 VSA 15751



 Score =  115 bits (288), Expect = 3e-25
 Identities = 177/727 (24%), Positives = 291/727 (40%), Gaps = 108/727 (14%)

Query: 384   PPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFR--QCFFGSQKHC--KL 438
             P +++  S  S  L W  P D G ++ITNY++E    KR SG    Q    S K    K+
Sbjct: 22375 PIEVSSVSAESCVLSWGEPKDGGGTEITNYIVE----KRESGTTAWQLVNSSVKRTQIKV 22430

Query: 439   TKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS 496
             T L   M Y+FR+++ N  G S    S  ++       P  P+ P +       ++++W 
Sbjct: 22431 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22490

Query: 497   KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTE 554
             +P      ++I Y +E +++ N  L+  +     L C  K   L    +Y+FR  A N  
Sbjct: 22491 EPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAA 22549

Query: 555   GKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE---- 610
             G S  SE      + +    P RP V   VT    S+ W  P  +GGS+++ Y++E    
Sbjct: 22550 GVSKASEASRPIMAQNPVDAPGRPEVTD-VTRSTVSLIWSAPAYDGGSKVVGYIIERKPV 22608

Query: 611   --ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGH-SQCSESLPVRTL 667
               + DG      + +    S   +T T L  G  Y+ R    +  G  S+ SES      
Sbjct: 22609 SEVGDGRWLKCNYTIV---SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST----- 22660

Query: 668   SIAPGQCR----PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE--------- 714
                P  CR    PP+        +  L  D+    +G ++   +    +PE         
Sbjct: 22661 --GPVTCRDEYAPPKA-----ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGD 22713

Query: 715   ---DVASEV---YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPG 768
                D+  +V   Y G      +         ++ +   N  G    S + ++  + GP G
Sbjct: 22714 KELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCG 22773

Query: 769   QCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT--DTRFEIR 825
             +     +  T + C L  W  P +  GA+I+ Y +E  E      +I  G      + + 
Sbjct: 22774 KLTVSRV--TQEKCTLA-WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVT 22830

Query: 826   DLLPAAQYCCRLQAFNQAGAGP--YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPS 883
              L+   +Y  R++A N+ G G    SE ++ +   + P P      + EE       +  
Sbjct: 22831 RLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG----IPEEV-----GTGK 22881

Query: 884   ACLVLNWEEP-CNNGSEILAYTIDLGDTS----------ITVGNTTMHVMKDLLPETTYR 932
               +++ W +P  + G+EI  Y +D  +              V +T + V   L+    Y+
Sbjct: 22882 EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTS-LMEGCDYQ 22940

Query: 933   IRIQAINEIG---AGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              R+ A+N  G       S FI  +     P PP  PR+        S+ L W  +     
Sbjct: 22941 FRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV--VDTTKHSISLAW--TKPMYD 22996

Query: 987   AAEDIV-YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTC--------YSFRIQAASEAG 1037
                DIV Y L++++++      YR   HT    R TEFT         YSFR+ A +  G
Sbjct: 22997 GGTDIVGYVLEMQEKDTD--QWYR--VHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 23052

Query: 1038  EGPFSET 1044
                +SE+
Sbjct: 23053 MSEYSES 23059



 Score =  114 bits (284), Expect = 7e-25
 Identities = 219/964 (22%), Positives = 367/964 (38%), Gaps = 124/964 (12%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             EKP+VSN+      +SW  PV        G S    Y V   +K      + I +   +L
Sbjct: 14204 EKPEVSNVTKNTATVSWKRPVD------DGGSEITGYHVERREKKSLRWVRAIKTPVSDL 14257

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH---RSKSSL 395
              C +  L+  + Y  RV A   +  G  SE         A   P PP   H    +K S 
Sbjct: 14258 RCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSA 14317

Query: 396   TLQWKAP-IDNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
             +L W  P  D G +IT Y++E        W +    +  R   F       +  L     
Sbjct: 14318 SLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQF------VVPDLQTKEK 14371

Query: 447   YTFRLAARNDIGTSGYSQ----EVVCYTLGNIPQMPSAPR---LVRAGITWVTLQWSKPE 499
             Y FR++A ND G    +     E+V   +    ++ +  R   +VRAG++   ++   P 
Sbjct: 14372 YNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLS---IRIFVPI 14428

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQY---KFRLTASNTEGK 556
                P   +T+T      +N NL +        + T+  +    +Y   KF +T  N  GK
Sbjct: 14429 KGRPAPEVTWT-----KDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK 14483

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
                    V     D PGP    L    +T    ++ WD P  +GGS I  Y++E  +   
Sbjct: 14484 KSG---FVNVRVLDTPGPVLN-LRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATR 14539

Query: 617   EANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
             ++           T Y  T L  G  Y  R    +  G  + +E+      S AP     
Sbjct: 14540 KSYSTATTKCHKCT-YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS 14598

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLP 735
               ++   K   V L W  P  + G +++ Y +E   +  D  + +     LEC V NL  
Sbjct: 14599 LNIMDITK-STVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14657

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             G  Y F+V A+N  G     +   +        Q   P +        LV  ++ D+   
Sbjct: 14658 GEEYTFQVMAVNSAGRSAPRESRPVIVKE----QTMLPELDLRGIYQKLVIAKAGDNIKV 14713

Query: 796   DI-----SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
             +I      +  + W + ++ L+         FE      A      +    ++ +GPY  
Sbjct: 14714 EIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVRSDSGPYP- 14765

Query: 851   LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP-------SACLVLNWEEPCNNGS-EILA 902
                  T  +    V  +  ++   +   P  P       S  +  +W+ P N+G   I  
Sbjct: 14766 ----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISN 14821

Query: 903   YTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKA 952
             Y +++  T        + TV  TT    + L     Y+ R++A N  G GP   S  I A
Sbjct: 14822 YVVEMRQTDSTTWVELATTVIRTTYKATR-LTTGLEYQFRVKAQNRYGVGPGITSACIVA 14880

Query: 953   KTRPLPPLPPRL-ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIY 1008
                   P PP   +  A    S+ + W +  S    +  + Y ++ ++RN    + +S  
Sbjct: 14881 NYPFKVPGPPGTPQVTAVTKDSMTISWHEPLS-DGGSPILGYHVERKERNGILWQTVSKA 14939

Query: 1009  RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEG 1067
               P + +K   LT+   Y FR+ A + AG+  P   +        + P  K P    +  
Sbjct: 14940 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK-PVPLNITR 14998

Query: 1068  NSCEILWETVPSMKGDPV-NYILQ---VLVGR--ESEYKQVYKGEEATFQISGLQTNTDY 1121
             ++  + W       G  + +YI++   +  GR  ++ +  + + E   F +SGL  +  Y
Sbjct: 14999 HTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE---FTVSGLTEDAAY 15055

Query: 1122  RFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAA 1181
              FRV A        +  +GA SP +    + S+ +   D   ++ PK+K     D +F  
Sbjct: 15056 EFRVIA--------KNAAGAISPPS----EPSDAITCRD--DVEAPKIK----VDVKFKD 15097

Query: 1182  IIVL 1185
              ++L
Sbjct: 15098 TVIL 15101



 Score =  113 bits (283), Expect = 1e-24
 Identities = 196/861 (22%), Positives = 330/861 (38%), Gaps = 95/861 (11%)

Query: 325   RDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMY---NSVKGSCSEPVSFTTHSCAPEC 381
             R  K  ++Y   +    +  L    DY  RV A+    NS     S  +S    S  P  
Sbjct: 22916 RVNKDYVVY---DTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGP 22972

Query: 382   PFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK 440
             P  P++   +K S++L W  P+ D G+ I  Y+LE  E   +  +R     + ++ + T 
Sbjct: 22973 PSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23032

Query: 441   LCPAMG--YTFRLAARNDIGTSGYSQ---EVVCYTLGNIPQMPSAPRL-----VRAGITW 490
                 MG  Y+FR+AA N  G S YS+   E+       IP +  A  L     +RAG   
Sbjct: 23033 PDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG--- 23089

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              +L+        P  VIT++ +  +  +  +     T       V  + R    K+ + A
Sbjct: 23090 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT--TESYSLLIVDKVNRYDAGKYTIEA 23147

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  GK   +   V     D PGP     VK  V+    ++ W+ P  +GG+ +  Y++E
Sbjct: 23148 ENQSGKKSAT---VLVKVYDTPGPCPSVKVK-EVSRDSVTITWEIPTIDGGAPVNNYIVE 23203

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC---CISTGGHSQCSESLPVRTL 667
               +    A +  V    S T Y  + L  GT+Y  R         G   + S+++ V  +
Sbjct: 23204 KREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV 23262

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP--EDVASEVYHGPE 725
              + P +     V        V L W+ P  + G  ++ Y +E  +   E     V   P 
Sbjct: 23263 PLVPAKLEVVDVT----KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPT 23318

Query: 726   -LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT------ 778
              LE TV +L  G  Y FR+RA N+ G    S+  E  TA         P I  +      
Sbjct: 23319 VLEHTVTSLNEGEQYLFRIRAQNEKGV---SEPRETVTAVTVQDLRVLPTIDLSTMPQKT 23375

Query: 779   ---PDG-----CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD--LL 828
                P G      + +    P ++    +  +L    + E + +  H    +  IR+  + 
Sbjct: 23376 IHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR---ESERVTVETHTKVAKLTIRETTIR 23432

Query: 829   PAAQYCCRLQAFNQAGAGPYS-ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV 887
                +Y   L+  N  G    + ++++   P     P+        + +DA        + 
Sbjct: 23433 DTGEYTLELK--NVTGTTSETIKVIILDKPGPPTGPIKI------DEIDA------TSIT 23478

Query: 888   LNWEEP-CNNGSEILAYTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAI 938
             ++WE P  + G+ +  Y ++  D         S +V  +T    + L     Y  R+ A 
Sbjct: 23479 ISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTR-LTEGNEYVFRVAAT 23537

Query: 939   NEIGAGPF--SQFIKAKTRPLPPLPPR-LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
             N  G G +  S+ I+ ++    P PP  L+        + L W        +        
Sbjct: 23538 NRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE 23597

Query: 996   QLEDRNKRFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
             + E R  R++ + + P     Y+   LTE   Y  R+ A +  G G P   +        
Sbjct: 23598 RKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDP 23657

Query: 1053  VPPTIKA--PRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQ--VYKGEE 1107
             + P  K   PRVT     S  + W       G  V  Y++++    + E+ +      + 
Sbjct: 23658 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKI 23717

Query: 1108  ATFQISGLQTNTDYRFRVCAC 1128
               + ++ L    +YRFRV AC
Sbjct: 23718 REYTLTHLPQGAEYRFRVLAC 23738



 Score =  112 bits (281), Expect = 2e-24
 Identities = 187/798 (23%), Positives = 293/798 (36%), Gaps = 83/798 (10%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P PP+   ++   K S  L WK P+D+G S ITNY++E  +   ++ +      S+K   
Sbjct: 10938 PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKKSH 10996

Query: 438   LTK-LCPAMGYTFRLAARNDIGTSGYSQE---VVCYTLGNIPQMPSAPRLVRAGITWVTL 493
               K L     Y FR+AA N  G   + +    +      + P  P     V    T V+L
Sbjct: 10997 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 11056

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
              W+KP+      +  Y +E QE+   +    K T  +L C V  L++   Y+FR+ A N 
Sbjct: 11057 VWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAENI 11115

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTR---PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              G   P   +          P       L++G V   G +V++            K+   
Sbjct: 11116 VGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-- 11173

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              TDG SE    E         YT       ++  ++ C     G  Q + S    + ++A
Sbjct: 11174 -TDG-SEIKTDE--------HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVA 11223

Query: 671   --------PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVY 721
                     PG    P  +     + + + W  P  + G  V  Y VE  +  +D    V 
Sbjct: 11224 VHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVS 11283

Query: 722   HGP-ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISC 777
              G  + +  + +L  G  Y FRVRA N  G GP  D S  T A     PP     P ++ 
Sbjct: 11284 SGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLD-STPTVAKHKFSPPSPPGKPVVTD 11342

Query: 778   TPDGCVLVGWESPDSSGAD-ISEYRLEWGEDEESLELIYHG--TDTRFEIRDLLPAAQYC 834
               +    V W  P S G   I+ Y +E  E       +      D +F +  L     Y 
Sbjct: 11343 ITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 11402

Query: 835   CRLQAFNQAGAG---PYSELVLCQTPASAPDPVSTLCVLEEEPLDA-YPDSPSACLVLNW 890
              R+ A N AG     P S+ +    P   P P          P++    D       L W
Sbjct: 11403 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGP----------PINPKLKDKSRETADLVW 11452

Query: 891   EEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKD------------LLPETTYRIRIQA 937
              +P ++G S IL Y ++         N    + KD            L+    YR RI+A
Sbjct: 11453 TKPLSDGGSPILGYVVECQKPGTAQWN---RINKDELIRQCAFRVPGLIEGNEYRFRIKA 11509

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGD-----SNSKTHAAEDIV 992
              N +G G   +  ++        PP +E        + ++ G      +  K     DI 
Sbjct: 11510 ANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDIT 11569

Query: 993   YTLQ--LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             +T +  +  R KR   I   P    +++         + I A + +G    S        
Sbjct: 11570 WTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGS---AIVNV 11626

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
                P   +  +VT +   +C I WE      G  + N+I++     +  +  V       
Sbjct: 11627 LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11686

Query: 1110  FQISGLQTNTDYRFRVCA 1127
                + L  N +Y FRVCA
Sbjct: 11687 LIKANLLANNEYYFRVCA 11704



 Score =  112 bits (279), Expect = 3e-24
 Identities = 202/906 (22%), Positives = 332/906 (36%), Gaps = 95/906 (10%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             + P+V+ +    + + W PP       + G      Y +   +K       +  S   E 
Sbjct: 12028 DPPEVTKVSKEEMTVVWNPP------EYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPER 12081

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSL 395
                +++L P  +Y  RV A      G  S P          E P PP   ++   +K S+
Sbjct: 12082 RMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSI 12141

Query: 396   TLQWKAPI-DNGSKITNYLLEWD----EGKRNSGFRQCFFGSQ---KHCKLTKLCPAMGY 447
             TL W  P+ D G+ I  Y++E      +   + G+++C   +Q   K   +T L     Y
Sbjct: 12142 TLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEY 12201

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR--------LVRAG--ITWVTLQWSK 497
              FR+ A+N +G    ++         I + P            +VRAG  I    +   +
Sbjct: 12202 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 12261

Query: 498   PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS 557
             P        +     +++ + D +    +        + N  R    K+ LT  N  G+ 
Sbjct: 12262 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFL------VIPNSTRDDSGKYSLTLVNPAGEK 12315

Query: 558   CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
                 V V     D PGP +  L    VT     V W PP+++GGS++  Y++E  +  ++
Sbjct: 12316 A---VFVNVRVLDTPGPVS-DLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKRE--AD 12369

Query: 618   ANQWE-VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP-GQCR 675
                W  V      T +  T+L PG  Y  R   ++  G    ++ +P   L+  P  +  
Sbjct: 12370 RKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTD-VPKPVLASDPLSEPD 12428

Query: 676   PPRVL--GRPKHKEVHLEWDVPASESGCEVSEYSV---EMTEPEDVASEVYHGPELECTV 730
             PPR L           L W  P  + G ++  Y     E  +P D  +E     +L   V
Sbjct: 12429 PPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVV 12488

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE-- 788
               L  G  Y+FRV A N  G     +   +  A     Q   P I       +  G +  
Sbjct: 12489 TGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA---KEQLLPPKILMPEQITIKAGKKLR 12545

Query: 789   -SPDSSGADISEYRLEWGEDE--ESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQA 843
                   G      + + GEDE   S  L  H  D+     I+D+         L A N +
Sbjct: 12546 IEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12605

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILA 902
             G       V+       P P          P D       AC  L+W  P  + GS I  
Sbjct: 12606 GTDTQKIKVVVMDAPGPPQP----------PFDISDIDADAC-SLSWHIPLEDGGSNITN 12654

Query: 903   YTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAK 953
             Y ++  D S         +V  T+  V K L+P   Y  R++A N  G + P +      
Sbjct: 12655 YIVEKCDVSRGDWVTALASVTKTSCRVGK-LIPGQEYIFRVRAENRFGISEPLTSPKMVA 12713

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN-----KRFIS 1006
               P  +P  P            + + W D       +  I Y ++ ++RN     K   +
Sbjct: 12714 QFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLIERKERNSLLWVKANDT 12772

Query: 1007  IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
             + R  S  Y    L E   YSFRI A ++AG  P S+   + T +        P V  + 
Sbjct: 12773 LVR--STEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVT 12830

Query: 1067  GNSCEILWETVPSMKGDP-VNYILQVLVGRESEYKQV----YKGEEATFQISGLQTNTDY 1121
              ++  ++W       G   + Y ++       ++ +     ++  +  +  +GL+    Y
Sbjct: 12831 KSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQY 12890

Query: 1122  RFRVCA 1127
             +FR  A
Sbjct: 12891 QFRAIA 12896



 Score =  109 bits (273), Expect = 1e-23
 Identities = 207/916 (22%), Positives = 353/916 (38%), Gaps = 89/916 (9%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             V  ++  +  L W PP+        G +   +Y +   +  R     +     +    ++
Sbjct: 17752 VKEVRKDSAFLVWEPPI------IDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVE 17805

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
             +L     Y+ RV A      G   E V     +  P  P    L   S++S +L W+ P 
Sbjct: 17806 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17865

Query: 404   -DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTS 460
              D GS++  Y++E          +       K C   +T L     Y FR+ A N+ G S
Sbjct: 17866 HDGGSRVLGYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS 17922

Query: 461   G---YSQEVVCYTLGNIP--QMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                     V+   L   P  ++P     ++AG     L+   P    P   I++  + + 
Sbjct: 17923 DPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAG---EDLKIEIPVIGRPRPNISWVKDGEP 17979

Query: 516   DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              +     + + T       +K   +    K+ +TA+N+ G +  +  ++     ++PGPP
Sbjct: 17980 LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL---EKPGPP 18036

Query: 576   TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VAYSGSATEYTF 634
               P+    V++    + W+PP   GG +I  Y++E  D  +    W  V+ + + T    
Sbjct: 18037 VGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRD--TTTTTWHMVSATVARTTIKI 18094

Query: 635   THLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEW 692
             T LK GT Y+ R    +  G S    S+++ V+     PG    P V    K  ++ ++W
Sbjct: 18095 TKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISK-DQMLVQW 18153

Query: 693   DVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDG 749
               P ++ G ++  Y +E  E   +     +   ++ T      L  G  Y F+V A N  
Sbjct: 18154 HEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIV 18213

Query: 750   GYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWG 805
             G G  S VSE   A     PPG+ +A  I+      V + W+ P    G+ I+ Y +E  
Sbjct: 18214 GIGKPSKVSECFVARDPCDPPGRPEAIVIT---RNNVTLKWKKPAYDGGSKITGYIVEKK 18270

Query: 806   E--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAG--------AGPYSELVLC 854
             +  D   ++  +    +T F +  L+   +Y  R+ A N AG        +G  +     
Sbjct: 18271 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEI 18330

Query: 855   QTPASAPDP----VSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
               P ++ DP    V  +   E   L+A     P   +V  W +   +G E L  T    +
Sbjct: 18331 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVV--WSK---DGKE-LEETAARME 18384

Query: 910   TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAA 969
                T+  TT+ V+KD +     +  ++  N  G       +K   RP PP  P L+    
Sbjct: 18385 IKSTIQKTTL-VVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP-LKVTGV 18442

Query: 970   GPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH----TYKVQRLTEFTC 1025
               +   L W   N         +    +E R    +S  +  +      YKV +L     
Sbjct: 18443 TAEKCYLAW---NPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNE 18499

Query: 1026  YSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             Y FR+ A ++ G G   E+   T       P     P V+ +  +S  + W       G 
Sbjct: 18500 YIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGT 18559

Query: 1084  PV-NYILQVLVGRESEYKQVYKGEEAT-----FQISGLQTNTDYRFRVCACRRCLDTSQE 1137
              +  YIL+    R+ E  +  K  + T      +++GL     Y FRV A        + 
Sbjct: 18560 EIEGYILE---KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAA--------EN 18608

Query: 1138  LSGAFSPSAAFVLQRS 1153
              +G   PS   V  R+
Sbjct: 18609 AAGVGEPSEPSVFYRA 18624



 Score =  109 bits (272), Expect = 2e-23
 Identities = 217/913 (23%), Positives = 347/913 (38%), Gaps = 114/913 (12%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+N+      +SW  P  L  G     +F   Y      K     + I+ S        
Sbjct: 11637 KVTNVTKENCTISWENP--LDNGGSEITNFIVEYR-----KPNQKGWSIVASDVTKRLIK 11689

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
              +L    +Y+ RV A      G   E   P+        P  P    +A + K+ + L+W
Sbjct: 11690 ANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKW 11749

Query: 400   KAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK--HCKLTKLCPAMGYTFRLAARND 456
             + P  D GS   +Y +E    K +  + +   GS K  H  + +      Y FR+  +N+
Sbjct: 11750 RRPDYDGGSPNLSYHVE-RRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 11808

Query: 457   IGTSGY--SQEVVCYTLGNIPQMP---SAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
              G S +  ++EVV       P +    S    V+AG T + L+        PE  + +T 
Sbjct: 11809 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDT-IRLEAGVRGKPFPE--VAWTK 11865

Query: 512   EIQEDENDNLFHPKYT----GEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +  +D  D    P+       +    ++   KRS   K+ +TA+NT G    S V   T 
Sbjct: 11866 D--KDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG----SFVAYATV 11919

Query: 568   SP-DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
             +  D+PGP  R L    V+S   +V WDPP+D+GG EI  Y+LE  +  ++   W   YS
Sbjct: 11920 NVLDKPGP-VRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCE--TKRMVWS-TYS 11975

Query: 627   GSATE--YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPRVLGR 682
              +      T T L  G  Y  R    +  G    +ES PV  +T    PG+  PP V  +
Sbjct: 11976 ATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-K 12034

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVY 739
                +E+ + W+ P  + G  ++ Y +E  E      V       PE    V NLLP   Y
Sbjct: 12035 VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEY 12094

Query: 740   RFRVRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
             +FRV+A N+ G G  S  S    A     PPG      +  T    + +GW  P    GA
Sbjct: 12095 QFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGA 12154

Query: 796   DISEYRLE-------------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQ 842
              I  Y +E             W     + +L+       F +  L    +Y  R+ A NQ
Sbjct: 12155 PIIGYVVEMRPKIADASPDEGWKRCNAAAQLV----RKEFTVTSLDENQEYEFRVCAQNQ 12210

Query: 843   AGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
              G G          PA   + +    +LE   +D   D+    LV+        G  I  
Sbjct: 12211 VGIG---------RPAELKEAIKPKEILEPPEIDL--DASMRKLVI-----VRAGCPIRL 12254

Query: 903   YTIDLGDTS-------ITVGNTTMHVMKDL--------LPETTY----RIRIQAINEIGA 943
             + I  G  +       + + N       DL        +P +T     +  +  +N   A
Sbjct: 12255 FAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP--A 12312

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
             G  + F+  +    P     L+ +     S  + W    +   +        + E   K 
Sbjct: 12313 GEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT 12372

Query: 1004  FISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG---PFSETYTFSTTKSVPPTIKA 1059
             + ++      T + V  L     Y FR+ A +E G G      +    S   S P   + 
Sbjct: 12373 WSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRK 12432

Query: 1060  PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE-----YKQVYKGEEATFQISG 1114
               VT++  NS  + W  +P ++         +   RE E     + +    ++ +  ++G
Sbjct: 12433 LEVTEMTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG 12490

Query: 1115  LQTNTDYRFRVCA 1127
             L+    Y+FRV A
Sbjct: 12491 LKEGKKYKFRVAA 12503



 Score =  108 bits (271), Expect = 2e-23
 Identities = 153/654 (23%), Positives = 249/654 (38%), Gaps = 100/654 (15%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGS--QKH 435
            P PP+   +      S  L W AP+DNG S+IT+Y+++  +  R     +    +  +K 
Sbjct: 9126 PSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKR 9185

Query: 436  CKLTKLCPAMGYTFRLAARNDIGTSGY--SQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
              + KL P   Y FR+ A N  G S    S +VV      +P  P  P+++      + +
Sbjct: 9186 YGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLV 9245

Query: 494  QWSKPEGCSPEEVITYTLEIQEDENDNLFH------PKYTGEDLTCTVKNLKRSTQYKFR 547
             W+ P       +  Y LE +E+ +            K   + +   V  L    +Y+FR
Sbjct: 9246 SWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFR 9305

Query: 548  LTASNTEGKSCPSEVLVCTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEI 604
              A N  G   PSE      + D    PGPP+ P VK   T    S+ W PP  +GGS I
Sbjct: 9306 AMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDK-TKSSISLGWKPPAKDGGSPI 9364

Query: 605  LKYLLEITDGNSEANQWEVAYSG----SATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
              Y++E+ +  +    W+         +  E    +LK    Y+ R   ++  G S+ S+
Sbjct: 9365 KGYIVEMQEEGT--TDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSD 9422

Query: 661  S---LPVRTLSIAP-----------------GQCRPPRVL-GRPKHKEVHLEWDVPA-SE 698
            +   +P   +   P                  Q R P V+ GRP  K     W+    ++
Sbjct: 9423 TTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKS---SWEFDGKAK 9479

Query: 699  SGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVS 758
               +   + +    PED   E      +   +         ++ + A N  G    +   
Sbjct: 9480 KAMKDGVHDI----PEDAQLETAENSSV-IIIPECKRSHTGKYSITAKNKAGQKTANCRV 9534

Query: 759  EITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGAD-ISEYRLEWG--EDEESLELIY 815
            ++    GPP   K   +S    G   + W+ PD  G D I  Y +E    + +   ++  
Sbjct: 9535 KVMDVPGPPKDLK---VSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNP 9591

Query: 816  HGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPL 875
                T F + DLL   QY  R++A N+ G GP  E +   T   A DP+           
Sbjct: 9592 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT---ARDPI----------- 9637

Query: 876  DAYPDSPSACLV----------LNWEEPCNNG-SEILAYTIDL--GDTSITVGNT----- 917
              YP  P   L           L+W+ P N+G S +  Y ++    D + T         
Sbjct: 9638 --YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCN 9695

Query: 918  ------TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                      ++DL+    Y  R++A+N  G    S  +       P +PP ++
Sbjct: 9696 KRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 9749



 Score =  103 bits (256), Expect = 1e-21
 Identities = 216/952 (22%), Positives = 362/952 (38%), Gaps = 106/952 (11%)

Query: 280  EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
            +KP V ++ + ++++ W  P   +  P  G       EV  +   R  K  +      L+
Sbjct: 8535 DKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLE-KREVNSTHWSRVNKSLL----NALK 8588

Query: 340  CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVS-FTTHS-CAPECPFPPKLAHRSKSSLTL 397
             N+  L     Y  RV A   +  G  S P    T H   +P  P  P++   S +++ L
Sbjct: 8589 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIEL 8648

Query: 398  QWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPAMGYTFRL 451
            +W+ P  NG  +I  Y ++    K+  G  +    ++K  K+ +     +     Y  R+
Sbjct: 8649 EWEPPAFNGGGEIVGYFVD----KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 8704

Query: 452  AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---VRAGITWV---TLQWSKPEGCSPEE 505
            +A N  G  G   E    T+   PQ P A  L   V+ GI  +   TL+        P  
Sbjct: 8705 SAVNAAG-EGPPGETQPVTVAE-PQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVP 8762

Query: 506  VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
               +T E  E + D +      G      +K+  R    ++ +TA+N    SC S+    
Sbjct: 8763 TKVWTKEEGELDKDRVVIDN-VGTKSELIIKDALRKDHGRYVITATN----SCGSKFAAA 8817

Query: 566  TTSP-DRPGPPTRPLVKGPVTSHGFSV-KWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
                 D PGP     +K  VT+    +  W  P+D+GGSEI  +++E  D  ++ + W  
Sbjct: 8818 RVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKD--AKMHTWRQ 8873

Query: 624  AYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP 683
                  ++   T L  G  YK R    +  G     E  P+  +        P R+    
Sbjct: 8874 PIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTE 8933

Query: 684  KHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGTVY 739
            + K  + L+W  P S  G  +  Y +E    +    E  +    P     V NL    +Y
Sbjct: 8934 RTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMY 8993

Query: 740  RFRVRALND-GGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS 798
             FRV+A+N+ G   P   ++ +      P   K   +S   D  + V    P    AD++
Sbjct: 8994 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLR-LSVRGD-TIKVKAGEPVHIPADVT 9051

Query: 799  EY---RLEWGEDEESL------------ELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                 ++EW ++E  +            E+      T   I   +   +    + A N+ 
Sbjct: 9052 GLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRL 9111

Query: 844  GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILA 902
            G+   +  V        P P   L V + +    Y         L W+ P +N GSEI  
Sbjct: 9112 GSVFRNVHV---EVYDRPSPPRNLAVTDIKAESCY---------LTWDAPLDNGGSEITH 9159

Query: 903  YTIDLGDTS------ITVGNTTM---HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
            Y ID  D S        V NT +   + +  L+P   Y  R++A+N+ G     +  K  
Sbjct: 9160 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVV 9219

Query: 954  TR-----PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
             +     P PP  P++     G  S+ + W        +     +  + E+ +  +  + 
Sbjct: 9220 IQDPYRLPGPPGKPKVLARTKG--SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVS 9277

Query: 1009 RGP-------SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS---VPPTIK 1058
            R P          + V RL E   Y FR  A + AG GP SE             P    
Sbjct: 9278 RAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPS 9337

Query: 1059 APRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEE----ATFQIS 1113
             P V     +S  + W+      G P+  YI+++     +++K+V + ++        + 
Sbjct: 9338 CPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVP 9397

Query: 1114 GLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLD 1165
             L+    YRFRV A     ++    +    P A  + +  EV +  D+G+ D
Sbjct: 9398 NLKELRKYRFRVKAVNEAGESEPSDTTGEIP-ATDIQEEPEVFI--DIGAQD 9446



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 204/939 (21%), Positives = 334/939 (35%), Gaps = 131/939 (13%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEEL------- 338
            ++ A+    +  PP  L+    +       +E   +D GR  +  +I   E L       
Sbjct: 7802 SVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKA 7861

Query: 339  ------ECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH- 389
                  +CN +  D+   T+   +V A   +  G  SEP    +       P PP   H 
Sbjct: 7862 GKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV 7921

Query: 390  --RSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK------ 440
                +  + + WK P  NG S I  Y +E            C  G++K  ++        
Sbjct: 7922 TDAGRKHIAIAWKPPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNSRPIKDL 7970

Query: 441  -------LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT- 492
                   + P   Y  R+ A N IG S  S E+    +   P       L    I  +  
Sbjct: 7971 KFKVEEGVVPDKEYVLRVRAVNAIGVSEPS-EISENVVAKDPDCKPTIDLETHDIIVIEG 8029

Query: 493  --LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              L    P    P   +++  + +E +  +    K         V    R+    + +T 
Sbjct: 8030 EKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITL 8089

Query: 551  SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             N  G +  S  +     P     P + +    +T     + W+PP+ +GG+ IL Y+LE
Sbjct: 8090 ENKLGSATASINVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 8145

Query: 611  ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              +         V    +   +T   L P   Y  R   ++  G  +  E L    ++  
Sbjct: 8146 RREA-GRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE-LKNPVIAQD 8203

Query: 671  PGQCRPPRV---LGRPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGP 724
            P Q   P V   +  P  + + + W  P  + G ++  Y +E     E        +  P
Sbjct: 8204 PKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 8263

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKA------------ 772
             L  T   L  G  Y+FRVRA N  G    S  +  T A  P    K             
Sbjct: 8264 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGD 8323

Query: 773  -------------PCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEE---------S 810
                         P I+   D  V+V  E    +   +   + E  E+E          S
Sbjct: 8324 EIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLS 8383

Query: 811  LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
            ++    G +++  +RD L        ++  N  G             A AP  VS L   
Sbjct: 8384 IDNSKKG-ESQLRVRDSLRPDHGLYMIKVENDHGI------------AKAPCTVSVLDTP 8430

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTS------ITVGNTTMHV-- 921
                   + D     ++  WE P ++ GSEI+ YT++  D +      I V +T  H   
Sbjct: 8431 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY 8490

Query: 922  -MKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPP-LPPRLECAAAGPQSLKLK 977
             +  L+    Y  R++A N  G GP   S+ + AK    PP  P +         S+ +K
Sbjct: 8491 SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVK 8550

Query: 978  WGDSNSKTHAAEDIVYTLQLEDRNKRFIS-IYRGPSHTYK--VQRLTEFTCYSFRIQAAS 1034
            W +   K + +  + Y L+  + N    S + +   +  K  V  L E   Y FR+ A +
Sbjct: 8551 WNE--PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAEN 8608

Query: 1035 EAGEGPFSETYTFSTTKS--VPPTIKAPRVTQLEGNSCEILWETVPSMK--GDPVNYILQ 1090
             AG G FS      T      PP    PRVT     + E+ WE  P+    G+ V Y + 
Sbjct: 8609 AAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEP-PAFNGGGEIVGYFVD 8667

Query: 1091 VLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              +   +E+ +  +   +   + +  ++   DY+ RV A
Sbjct: 8668 KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA 8706



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 90/306 (29%), Positives = 137/306 (44%), Gaps = 22/306 (7%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +  +IQ R+V +SW PP         G +    Y +   +  +   Y I          +
Sbjct: 23864 EYDDIQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLVV 23917

Query: 343   KDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPF-PPKLAHRSKSSLTLQ 398
             K L+   +YH RV A      S      EPV+  T    PE P  PP++   +KSS++L 
Sbjct: 23918 KGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLS 23977

Query: 399   WKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W  P D+G S++T Y +E  E   +   R      +     +T L P   Y FR+ A+ND
Sbjct: 23978 WSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQND 24037

Query: 457   IG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             +G   TS  S+ VVC    + P  P    ++      VTLQW KPE    +E++ Y +E 
Sbjct: 24038 VGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEY 24097

Query: 514   QEDENDNLFHP--KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC----TT 567
             ++   D+ +    K   +D   T+  L  +T+Y+FR+ A N  G S P    +      T
Sbjct: 24098 RQS-GDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLT 24156

Query: 568   SPDRPG 573
             S + PG
Sbjct: 24157 SGEAPG 24162



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 188/836 (22%), Positives = 298/836 (35%), Gaps = 141/836 (16%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPIDN-GSKITNYLLE--------WDEGKRNSGFRQ 427
             + P PPK   ++  ++ S  L WK P D+ G +I  Y++E        W +   + G   
Sbjct: 9538  DVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG--- 9594

Query: 428   CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-VRA 486
                       +  L     Y FR+ A N  G  G   E +  T    P  P  P + ++ 
Sbjct: 9595  -----STTFVVPDLLSEQQYFFRVRAENRFGI-GPPVETIQRTTARDPIYPPDPPIKLKI 9648

Query: 487   GI---TWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP------KYTGEDLTCTVKN 537
             G+     V L W  P+      V  Y +E    +             K   E+L  TV++
Sbjct: 9649  GLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 9708

Query: 538   LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVK----- 592
             L    +Y+FR+ A N  G S PS  +          PP+  L +      G +V      
Sbjct: 9709  LVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKI 9768

Query: 593   ---------W--DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGT 641
                      W   PPK     E + Y       ++  N+  V  + +           G 
Sbjct: 9769  KGVPFPTLTWFKAPPKKPDNKEPVLY-------DTHVNKLVVDDTCTLVIPQSRRSDTG- 9820

Query: 642   LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
             LY + A           S+ + +  L   PG    P         ++ L W  P  + G 
Sbjct: 9821  LYTITA----VNNLGTASKEMRLNVLG-RPGPPVGPIKFESVSADQMTLSWFPPKDDGGS 9875

Query: 702   EVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             +++ Y +E  E              EC  T+  LL G  Y FR+ A N  G G   D SE
Sbjct: 9876  KITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLD-SE 9934

Query: 760   ITTAA---GPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE--------- 806
               TA      PG    P +S      + V WE P+   G+ ++ Y LE  +         
Sbjct: 9935  PETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 9994

Query: 807   DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
             + + ++ +  G    +++  L+  + Y  R+ A N AG GP S   L   PA+A DP++ 
Sbjct: 9995  NRDPIKAMTLGVS--YKVTGLIEGSDYQFRVYAINAAGVGPAS---LPSDPATARDPIAP 10049

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTIDL---GDTSITVGNT----- 917
                    P     D   +   L W  P  + GS++  Y ++    G      G       
Sbjct: 10050 ----PGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 10105

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTRPLPPLPP------------ 962
             T  V+  L     Y+ R++A+N  G    G  +  I+ K R + P               
Sbjct: 10106 TKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVH 10165

Query: 963   -----RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKV 1017
                  R+    +G     + W + N +T   E  + T  +              S   K 
Sbjct: 10166 AGGVIRIIAYVSGKPPPTVTW-NMNERTLPQEATIETTAISS------------SMVIKN 10212

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVT-QLEGNSCEILWET 1076
              + +    YS  + A +EAGE    +         VP  +  P +   L   SC++ W +
Sbjct: 10213 CQRSHQGVYS--LLAKNEAGE---RKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 10267

Query: 1077  VPSMKGDPV-NYILQVLVGRESEYKQ----VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  G P+ NY+++    RES+ +      Y        + GL     Y FR+ A
Sbjct: 10268 PEDDGGSPITNYVIE---KRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAA 10320



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 217/939 (23%), Positives = 341/939 (36%), Gaps = 118/939 (12%)

Query: 271  RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
            +V D+   +   +V+      V L+W  P+        G S    Y V   D  R     
Sbjct: 6713 KVIDVPGPVRNLEVTETFDGEVSLAWEEPLT------DGGSKIIGYVVERRDIKRKTWVL 6766

Query: 331  IIYSGEELECNLKDLRPA-TDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPK 386
                 E  E  +  L+    +Y  RV A      G   E   PV   +    P  P    
Sbjct: 6767 ATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVT 6826

Query: 387  LAHRSKSSLTLQWKAP-IDNGSKITNYLLEW-DEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
            +   ++  ++L W+ P  D G++ITNY++E  D+                   +T +   
Sbjct: 6827 ITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEG 6886

Query: 445  MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQWSKP--E 499
              Y+FR+ A+N IG    S       + +  + PS P  L  +  T   V L+W  P  +
Sbjct: 6887 QEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKD 6946

Query: 500  GCSPEEVITYTLEIQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
            G SP  ++ Y +E  E+  DN          +LT  V  L++  +Y +R++A N  G S 
Sbjct: 6947 GGSP--ILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSD 7004

Query: 559  PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
            PSE+L   T+ D    PT  L        G  V    P        +  L+  T      
Sbjct: 7005 PSEILGPLTADDAFVEPTMDL---SAFKDGLEVIVPNP--------ITILVPSTGYPRPT 7053

Query: 619  NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQ-----CSESLPVRTLS----- 668
              W     G     T   +K  TL       IS    S            V+T+S     
Sbjct: 7054 ATW---CFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDV 7110

Query: 669  --IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE--PEDVASEVYHGP 724
              IA          G      VHL W+ P  + G  ++ Y VE  E   +     +    
Sbjct: 7111 NVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT 7170

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---ITTAAGPPGQCKAPCISCTPDG 781
            +LE TV +L+ G  Y F+V A N  G G  + V E   ++T A  P   +          
Sbjct: 7171 DLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN 7230

Query: 782  CVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLPAAQ 832
             + + W+ P +  G+ I  Y +E        W    E +       +T+ E+  L     
Sbjct: 7231 SIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPV------AETKMEVTGLEEGKW 7284

Query: 833  YCCRLQAFNQAGAG----PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL 888
            Y  R++A N+ GA     P  E+    T   AP+    + +L    + A         V 
Sbjct: 7285 YAYRVKALNRQGASKPSRPTEEIQAVDT-QEAPEIFLDVKLLAGLTVKAGTKIELPATVT 7343

Query: 889  NWEEPCNNGSEILAYTIDLGDTSITVGN----TTMHVMKDLLPETTYRIRIQAINEIGAG 944
               EP    ++  A  I   D  IT+ N    +T+ ++     +T   I I+A+N  G  
Sbjct: 7344 GKPEPKITWTK--ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRA 7400

Query: 945  PFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDR 1000
                 +    +P P  P   +      +S  L W     D  SK         T  + +R
Sbjct: 7401 TAVVEVNVLDKPGP--PAAFDITDVTNESCLLTWNPPRDDGGSK--------ITNYVVER 7450

Query: 1001 NKRFISIYRGPSHT-----YKVQRLTEFTCYSFRIQAASEAGEG------PFSETYTFST 1049
                  ++   S T     +K  +L     Y FR+ A +  G G      P +  Y F  
Sbjct: 7451 RATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDP 7510

Query: 1050 TKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--GE 1106
                PPT   P  + +  ++  + W       G P+  Y ++ L     ++ +  K   +
Sbjct: 7511 PG--PPTRLEP--SDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVK 7566

Query: 1107 EATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPS 1145
            + T+++ GL     YRFRV A        + L+G   PS
Sbjct: 7567 DTTYRVKGLTNKKKYRFRVLA--------ENLAGPGKPS 7597



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 195/897 (21%), Positives = 325/897 (36%), Gaps = 83/897 (9%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC--NLK 343
            +I+  +V+  W PP+        G S   +Y +   DK +     I+ +     C  ++ 
Sbjct: 8440 DIRKTSVLCKWEPPLD------DGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVT 8493

Query: 344  DLRPATDYHVRVYAMYNSVKGS--CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L    +Y  RV A      G    S+P+        P+ P  P +   + +S+ ++W  
Sbjct: 8494 KLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNE 8553

Query: 402  PIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
            P DNGS I  Y LE  E      S   +    + K   +  L   + Y FR+ A N  G 
Sbjct: 8554 PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALK-ANVDGLLEGLTYVFRVCAENAAGP 8612

Query: 460  SGYSQEVVCYTLGN--IPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ-ED 516
              +S      T  +   P  P  PR+     T + L+W  P      E++ Y ++ Q   
Sbjct: 8613 GKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVG 8672

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             N+     +   +    TVK ++    YK R++A N  G+  P E    T +  +  PP 
Sbjct: 8673 TNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQE-PPA 8731

Query: 577  RPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
              L   VKG +          P    G     K   +  +G  + ++  +   G+ +E  
Sbjct: 8732 VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTK-EEGELDKDRVVIDNVGTKSEL- 8789

Query: 634  FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQC--RPPRVLGRPKHKEVH 689
               +    L K     + T  +S C        + +   PG      P V  R   K   
Sbjct: 8790 ---IIKDALRKDHGRYVITATNS-CGSKFAAARVEVFDVPGPVLDLKPVVTNR---KMCL 8842

Query: 690  LEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP----ELECTVGNLLPGTVYRFRVRA 745
            L W  P  + G E++ + +E    +D     +  P      +C +  LL G  Y+FRV A
Sbjct: 8843 LNWSDPEDDGGSEITGFIIER---KDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIA 8899

Query: 746  LNDGGYGPYSDVSEITTA--AGPPGQCKAPCISCTPDGCVLVGWESPDSS-GADISEYRL 802
             N  G GP  ++  I      GPP   +    +      + + W+ P S+ G+ I  Y +
Sbjct: 8900 KNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYII 8959

Query: 803  E-WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPA 858
            E    D+   E +       T F + +L     Y  R++A N+ G + P   L +     
Sbjct: 8960 EKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDD 9019

Query: 859  SAPDPV--------STLCVLEEEPLDAYPDSPSACL-VLNW---EEPCNNGSEILAYTID 906
              P  +         T+ V   EP+    D     +  + W   E      ++ L  T +
Sbjct: 9020 EVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKE 9079

Query: 907  LGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLEC 966
              + S +   T + + K  + E      + A N +G+   +  ++   RP P  P  L  
Sbjct: 9080 --EVSRSEAKTELSIPK-AVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSP--PRNLAV 9134

Query: 967  AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFIS----IYRGPSHTYKVQRLTE 1022
                 +S  L W D+      +E   Y +   D +++               Y + +L  
Sbjct: 9135 TDIKAESCYLTW-DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9193

Query: 1023 FTCYSFRIQAASEAG--EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
               Y FR++A ++ G  +   S+         +P     P+V      S  + W      
Sbjct: 9194 NGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDN 9253

Query: 1081 KGDPV-NYILQ---------VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
             G P+  Y L+           V R    K   KG E  F +  L     Y+FR  A
Sbjct: 9254 GGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVE--FNVPRLLEGVKYQFRAMA 9308



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 143/644 (22%), Positives = 251/644 (38%), Gaps = 65/644 (10%)

Query: 527  TGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
            T E  +  +   K+  + ++++   N  GK+   E  +     D PGP  R L       
Sbjct: 6676 TAEQTSFRILEAKKGDKGRYKIVLQNKHGKA---EGFINLKVIDVPGP-VRNLEVTETFD 6731

Query: 587  HGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHL-KPGTLYK 644
               S+ W+ P  +GGS+I+ Y++E  D   +   W +A     + E+T T L K G  Y 
Sbjct: 6732 GEVSLAWEEPLTDGGSKIIGYVVERRD--IKRKTWVLATDRAESCEFTVTGLQKGGVEYL 6789

Query: 645  LRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPR--VLGRPKHKEVHLEWDVPASES 699
             R      + TG   +    +  R+    PG   PP    +       V L W+ P  + 
Sbjct: 6790 FRVSARNRVGTGEPVETDNPVEARSKYDVPG---PPLNVTITDVNRFGVSLTWEPPEYDG 6846

Query: 700  GCEVSEYSVEMTEPEDV---ASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSD 756
            G E++ Y +E+ +   +    +      +L  TV +++ G  Y FRVRA N  G G  S 
Sbjct: 6847 GAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSA 6906

Query: 757  VSEITTAAGPPGQCKAPCISCTPD---GCVLVGWESP-DSSGADISEY---RLEWGEDEE 809
             +     A P  +   P    + D     V + WE P    G+ I  Y   R E G+D  
Sbjct: 6907 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 6966

Query: 810  ---SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASA-PDPVS 865
               +++L+    +  +++  L    +Y  R+ A N+AG    SE++   T   A  +P  
Sbjct: 6967 IRCNMKLV---PELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTM 7023

Query: 866  TLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDL 925
             L    ++ L+    +P   LV +   P    +    +   + +T   V   T+    +L
Sbjct: 7024 DLSAF-KDGLEVIVPNPITILVPSTGYP--RPTATWCFGDKVLETGDRVKMKTLSAYAEL 7080

Query: 926  L-------PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW 978
            +        +  Y ++++   +  +G     + A+    P  P  L+       S+ L W
Sbjct: 7081 VISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR----PSAPKELKFGDITKDSVHLTW 7136

Query: 979  ------GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
                  G S    +  E    + +   +   F++        + V  L +   Y F++ A
Sbjct: 7137 EPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT-----DLEFTVPDLVQGKEYLFKVCA 7191

Query: 1033 ASEAGEGP---FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
             ++ G G      E    ST  +VP   +  +      NS  + W+   +  G  +   +
Sbjct: 7192 RNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYI 7251

Query: 1090 QVLVGRESEYKQVYKGE---EATFQISGLQTNTDYRFRVCACRR 1130
                 R S+ K V  GE   E   +++GL+    Y +RV A  R
Sbjct: 7252 VERCPRGSD-KWVACGEPVAETKMEVTGLEEGKWYAYRVKALNR 7294



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 66/238 (27%), Positives = 107/238 (44%), Gaps = 17/238 (7%)

Query: 535   VKNLKRSTQY-KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             +KN++R T   K+++  SN  G     + ++     D+P  PT P+V   +  +   + W
Sbjct: 24316 MKNVQRKTHAGKYKVQLSNVFGTV---DAILDVEIQDKPDKPTGPIVIEALLKNSAVISW 24372

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCIST 652
              PP D+GGS I  Y++E  +   E  +W++  S  S T     +L     Y  R    +T
Sbjct: 24373 KPPADDGGSWITNYVVEKCEA-KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNT 24431

Query: 653   GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYS 707
              G    S+ L V ++ I       P   G+P    V      + W  PAS+ G ++  Y 
Sbjct: 24432 FG---ISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYY 24488

Query: 708   VEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 762
             +E  E +    ++       E   +V NL+ G  Y FRV+  N GG   +S++SE  T
Sbjct: 24489 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT 24546



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 171/823 (20%), Positives = 290/823 (35%), Gaps = 78/823 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG--EELE 339
             P+V +    ++ L+W  P+      + G +    Y + + +K  D  Y++  +      E
Sbjct: 22976 PRVVDTTKHSISLAWTKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 23029

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP-KLAHRSKSSLTLQ 398
               + DL+    Y  RV A+  +VKG      S            P  +LA   K ++T++
Sbjct: 23030 FTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIR 23087

Query: 399   WKAPIDNGSKITNY---LLEWDEGKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
               A +     ++     ++ W +   +   R     ++ +  L   K+       + + A
Sbjct: 23088 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 23147

Query: 454   RNDIGTSGYSQEVVCY-TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE 512
              N  G    +  V  Y T G  P +    ++       VT+ W  P       V  Y +E
Sbjct: 23148 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWEIPTIDGGAPVNNYIVE 23203

Query: 513   IQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
              +E                   +  L   T Y FR+   N  G   P E        + P
Sbjct: 23204 KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVP 23263

Query: 573   GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
               P + L    VT    ++ W+ P  +GGS +  Y+LE     +E     V    +  E+
Sbjct: 23264 LVPAK-LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 23322

Query: 633   TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPG---QCRPPRVL----GR 682
             T T L  G  Y  R    +  G S+  E   ++ V+ L + P       P + +    GR
Sbjct: 23323 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGR 23382

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
             P    + +    P + S         ++ E E V  E  H    + T+          + 
Sbjct: 23383 PVELVIPIAGRPPPAASWFFAGS---KLRESERVTVET-HTKVAKLTIRETTIRDTGEYT 23438

Query: 743   VRALNDGGYGPYSDVSEITTAAGPP-GQCKAPCISCTPDGCVLVGWESPD-SSGADISEY 800
             +   N  G    +    I    GPP G  K   I  T    + + WE P+   GA +S Y
Sbjct: 23439 LELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDAT---SITISWEPPELDGGAPLSGY 23495

Query: 801   RLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY--SELVLCQT 856
              +E  +      L +    T + F+   L    +Y  R+ A N+ G G Y  SE++ C++
Sbjct: 23496 VVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS 23555

Query: 857   PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID----LGDTS 911
                 P P  TL +          D     + L W  P  + GS++  Y ++      D  
Sbjct: 23556 SIRIPGPPETLQIF---------DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23606

Query: 912   ITVGNT----TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR------PLPPLP 961
             + V       T +    L     Y  R+ AIN  G+G  S+  K          P  P  
Sbjct: 23607 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQN 23666

Query: 962   PRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLT 1021
             PR+        SL     +    +     ++   +++       +        Y +  L 
Sbjct: 23667 PRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLP 23726

Query: 1022  EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQ 1064
             +   Y FR+ A +  G G  +E         VP T+K   + +
Sbjct: 23727 QGAEYRFRVLACNAGGPGEPAE---------VPGTVKVTEMLE 23760



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 195/894 (21%), Positives = 321/894 (35%), Gaps = 81/894 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+V ++   +V LSW+ P        +G       E +     R  K +I  +       
Sbjct: 23964 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERK-ETSTDKWVRHNKTQITTT----MYT 24018

Query: 342   LKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  L P  +Y  R+ A  +   S     SEPV        P  P   ++   SK S+TLQ
Sbjct: 24019 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 24078

Query: 399   WKAP-IDNGSKITNYLLEW----DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
             W+ P  D G +I  Y +E+    D   + S   +      K   +  L  A  Y FR+ A
Sbjct: 24079 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFA 24135

Query: 454   RNDIGTSGYSQEVVCY----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
              N+ G S   +  +      T G  P +    + V   +        +  G    ++  Y
Sbjct: 24136 ENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWY 24195

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
                 +E      +     G   T TV   ++  +  +   A+N  G+   S  L+   +P
Sbjct: 24196 RFG-KELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP 24254

Query: 570   D-RPGPPTRPLVKGPVTS----HGFSVKWDPPKDNG--GSEILKYLLEITDGNSEANQWE 622
                PG P +    G V S    H   +    P      G ++L+    IT  N+E     
Sbjct: 24255 QFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEH---- 24310

Query: 623   VAYSGSATEYTFTHLKPGTLY------KLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
                        +THL    +       K +    +  G       + ++     P +   
Sbjct: 24311 -----------YTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD---KPDKPTG 24356

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE---CTVGNL 733
             P V+         + W  PA + G  ++ Y VE  E ++ A        +    C + NL
Sbjct: 24357 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 24416

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISC-TPDGCVLVGWES 789
                  Y FRV A N  G     +VS +     P   PG    P I+  T D CV V W+ 
Sbjct: 24417 TENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCV-VAWKP 24475

Query: 790   PDS-SGADISEYRLEWGEDEESLELIYHGTDTR---FEIRDLLPAAQYCCRLQAFNQAGA 845
             P S  GA I  Y LE  E +++  +     + R   F +++L+   +Y  R++  N  G 
Sbjct: 24476 PASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGE 24535

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEE-EPLDAYPDSPS--ACLVLNWEEPC----NNGS 898
               +SE+    TP S   P+      EE   L+    S +   C V    +P       G 
Sbjct: 24536 SEWSEISEPITPKS-DVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGK 24594

Query: 899   EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP 958
             EI+A  +         G   + ++  +  +     +++A N+ G+   +  ++ +     
Sbjct: 24595 EIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKI 24653

Query: 959   PLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQ----LEDRNKRFISIYRGPSHT 1014
              LP  LE   A   +L+ +            D V T Q    L D N  +  I      +
Sbjct: 24654 HLPKTLEGMGA-VHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS 24712

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
                    E     F +  A     G   +T        VP   +  +V+ +  +S  + W
Sbjct: 24713 LVFPNGVERKDAGFYVVCAKNR-FGIDQKTVELDVA-DVPDPPRGVKVSDVSRDSVNLTW 24770

Query: 1075  ETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                 S  G  + NYI++        + +V +  E  + +  L   T Y+FRV A
Sbjct: 24771 TEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIA 24824



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 141/629 (22%), Positives = 239/629 (37%), Gaps = 64/629 (10%)

Query: 446   GYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITW--VTLQWSKPEGCSP 503
             G  + L A N  G+  +   V      + P  P  P  V  G+T    +L WS P     
Sbjct: 17321 GGQYILRASNVAGSKSFPVNVKVL---DRPGPPEGPVQV-TGVTSEKCSLTWSPPLQDGG 17376

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTEGKSCPSE 561
              ++  Y +E  + E   L       E +T ++K   L    +Y FR+ A N  G   P E
Sbjct: 17377 SDISHYVVE--KRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLE 17434

Query: 562   VL-VCTTSPD-RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
                V   +P   PGPP + L    +     +V W+ P  +GGSEI+ Y++E  D +    
Sbjct: 17435 SAPVLMKNPFVLPGPP-KSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI-- 17491

Query: 620   QWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLPVRTLS---IAPGQC 674
             +W        T+     T L     Y+ R    +  G  + S +            PG  
Sbjct: 17492 RWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPP 17551

Query: 675   RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPE-LECT---V 730
                 ++   K+  + L W  P  + G E+  Y VE+ + ++   ++      L  T   +
Sbjct: 17552 TNAHIVDTTKNS-ITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEI 17610

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD---GCVLVGW 787
               L     Y+ RV ALN  G G   + + +     P  + +AP +    +   G V+   
Sbjct: 17611 SKLTEHQEYKIRVCALNKVGLG---EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAG 17667

Query: 788   ESP----DSSGADISE--YRLEWGE--DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA 839
              S        G    E  +  E GE  D+  +E   + T    +  D   A +Y  +L+ 
Sbjct: 17668 GSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLEN 17727

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGS 898
                  +G  S  V  +     P P   L V E     A+         L WE P  + G+
Sbjct: 17728 ----SSGSKSAFVTVKV-LDTPGPPQNLAVKEVRKDSAF---------LVWEPPIIDGGA 17773

Query: 899   EILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIK 951
             ++  Y ID  +++        +  + T   +++L     Y  R+ A NE G G   + + 
Sbjct: 17774 KVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVD 17833

Query: 952   AKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR-NKRFISIYR 1009
             A     PP PP ++        S  L W +       +  + Y ++++ +  +++  +  
Sbjct: 17834 AVKAAEPPSPPGKVTLTDVSQTSASLMW-EKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE 17892

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGE 1038
                    V  L+    Y FR++A +E G+
Sbjct: 17893 SKVCNAVVTGLSSGQEYQFRVKAYNEKGK 17921



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 38/292 (13%)

Query: 888  LNWEEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKDLLPE------------TTYRIR 934
            L WEEP  +G S+I+ Y ++  D    +   T  +  D                  Y  R
Sbjct: 6736 LAWEEPLTDGGSKIIGYVVERRD----IKRKTWVLATDRAESCEFTVTGLQKGGVEYLFR 6791

Query: 935  IQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAED 990
            + A N +G G   +    ++A+++   P PP  +         + L W +       AE 
Sbjct: 6792 VSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTW-EPPEYDGGAEI 6850

Query: 991  IVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG------PF 1041
              Y ++L D+           R    +  V  + E   YSFR++A +  G G      PF
Sbjct: 6851 TNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPF 6910

Query: 1042 SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLV-GRESEY 1099
             +        S P  + +   TQ   +S ++ WE      G P+  YI++    G+++  
Sbjct: 6911 VKVADPIERPSPPVNLTSSDQTQ---SSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWI 6967

Query: 1100 KQVYK-GEEATFQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFV 1149
            +   K   E T++++GL+    Y +RV A  +  +    E+ G  +   AFV
Sbjct: 6968 RCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFV 7019



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 28/75 (37%), Positives = 36/75 (48%), Gaps = 1/75 (1%)

Query: 688   VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V+L W  PAS+ G +++ Y VE      +    V    E   TV NL   T Y+FRV A 
Sbjct: 24766 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24825

Query: 747   NDGGYGPYSDVSEIT 761
             N  G    S+ SE T
Sbjct: 24826 NKFGLSKPSEPSEPT 24840



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 3/91 (3%)

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             D P PP R +    V+    ++ W  P  +GGS+I  Y++E     + A +W        
Sbjct: 24748 DVPDPP-RGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE--KCATTAERWLRVGQARE 24804

Query: 630   TEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             T YT  +L   T Y+ R    +  G S+ SE
Sbjct: 24805 TRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24835



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 379   PECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P+ P   K++  S+ S+ L W  P  D GSKITNY++   E    +  R    G  +  +
Sbjct: 24750 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIV---EKCATTAERWLRVGQARETR 24806

Query: 438   LT--KLCPAMGYTFRLAARNDIGTSGYSQ 464
              T   L     Y FR+ A N  G S  S+
Sbjct: 24807 YTVINLFGKTSYQFRVIAENKFGLSKPSE 24835



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 1/101 (0%)

Query: 461   GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
             G  Q+ V   + ++P  P   ++       V L W++P      ++  Y +E      + 
Sbjct: 24736 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24795

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
                     E    TV NL   T Y+FR+ A N  G S PSE
Sbjct: 24796 WLRVGQARET-RYTVINLFGKTSYQFRVIAENKFGLSKPSE 24835


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  162 bits (410), Expect = 2e-39
 Identities = 201/810 (24%), Positives = 324/810 (40%), Gaps = 96/810 (11%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
            P PP    +   +  S  L W  P D+G SKITNY++E          +        + K
Sbjct: 7287 PGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 7346

Query: 438  LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQ 494
             TKL P   Y FR+AA N  G  G   +    T       P  P RL  + IT   VTL 
Sbjct: 7347 ATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLT 7405

Query: 495  WSKPEGCSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
            W +P+      +  Y +E  + + D      K   +D T  VK L    +Y+FR+ A N 
Sbjct: 7406 WCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENL 7465

Query: 554  EGKSCPS---EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             G   PS   E ++     D P PP +P VK  V      + W  P+ +GG++I  Y++E
Sbjct: 7466 AGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIESYVIE 7524

Query: 611  ITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPV--RT 666
            +    ++  +W  VA     T++    L  G  Y  R   ++  G S+ SE S PV  R 
Sbjct: 7525 MLKTGTD--EWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCRE 7582

Query: 667  LSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP-- 724
                P   R   V+   K+    L+W VP  + G  ++ Y VE  +      +       
Sbjct: 7583 KLYPPSPPRWLEVINITKNT-ADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVK 7641

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDG 781
            + +CTV  L  G++Y FRV A N  G   Y+++ +   A      PG   A  +      
Sbjct: 7642 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKR 7701

Query: 782  CVLVGWESPDSSGA-DISEYRLEWGEDEESLELIY------HGTDTRFEIRDLLPAAQYC 834
             V + WE P + G   I  Y +E    +E L   +       G D  F + D++   +  
Sbjct: 7702 HVDLKWEPPKNDGGRPIQRYVIE---KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQ 7758

Query: 835  CRLQAFNQAGAGPYSE---LVLCQTPASAPDPVSTLCVLEEEPLDAY-PDSPSACLVLNW 890
             +++A N+AG G  SE   ++  + P S P P          PLD +  D+    + + W
Sbjct: 7759 FQVRAENEAGVGHPSEPTEILSIEDPTSPPSP----------PLDLHVTDAGRKHIAIAW 7808

Query: 891  EEP-CNNGSEILAYTIDLGDT---------SITVGNTTMHVMKDLLPETTYRIRIQAINE 940
            + P  N GS I+ Y +++            S  + +    V + ++P+  Y +R++A+N 
Sbjct: 7809 KPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNA 7868

Query: 941  IGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH-----AAEDIVYTL 995
            IG    S+  +      P   P ++                  +TH       E +   +
Sbjct: 7869 IGVSEPSEISENVVAKDPDCKPTIDL-----------------ETHDIIVIEGEKLSIPV 7911

Query: 996  QLEDRNKRFISIYRGPSHTYKVQRLT---EFTCYSFRIQAASEAGEGPFS---ETYTFST 1049
                     +S ++         RLT   +       +  +  A  G ++   E    S 
Sbjct: 7912 PFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 7971

Query: 1050 TKSV-------PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQ 1101
            T S+       P   K  + + +  +SC++ WE      G P+ +Y+L+        Y  
Sbjct: 7972 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8031

Query: 1102 VYKGE-EATFQISGLQTNTDYRFRVCACRR 1130
            V  GE + ++ +  L  N +Y FRV A  +
Sbjct: 8032 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8061



 Score =  157 bits (396), Expect = 8e-38
 Identities = 220/917 (23%), Positives = 369/917 (40%), Gaps = 77/917 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D     +  +V  +   +V L+W PP+        G S   +Y V   +  R     
Sbjct: 15450 RVLDTPGPPQDLKVKEVTKTSVTLTWDPPL------LDGGSKIKNYIVEKRESTRKAYST 15503

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             +  +  +    +  L+    Y+ RV A      G  +E       S  P  P    L   
Sbjct: 15504 VATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDV 15563

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W+ P  D GS+I  Y++E  + K +  +  C         +T L     Y+F
Sbjct: 15564 TRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSF 15622

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT---LQWSKPEGCSPEEV 506
             R++A+N+ G S   Q  V     ++  +P A +L+    T +    L+   P    P   
Sbjct: 15623 RVSAQNEKGISDPRQLSVPVIAKDLV-IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPA 15681

Query: 507   ITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT 566
             +T+  +    +     + + T  +   T+K+  R     + +  +N+ G++  +  ++  
Sbjct: 15682 VTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVL 15741

Query: 567   TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
                D+PGPPT P+    VT+   ++ W PPK +GGS I  Y++E  D  +    W++  +
Sbjct: 15742 ---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRD--TSTTTWQIVSA 15796

Query: 627   GSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP-- 683
               A T      LK G  Y+ R    +  G S    S P    ++A    + P   G P  
Sbjct: 15797 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEP----TVAQYPFKVPGPPGTPVV 15852

Query: 684   ---KHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGT 737
                    + ++W+ P S+ G  V  Y +E  E   +     +    P+ +     L  G 
Sbjct: 15853 TLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGV 15912

Query: 738   VYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SS 793
              Y FRV A N  G G  S VSE   A     PPG+ +A  ++      V + W+ P    
Sbjct: 15913 EYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVT---RNSVTLQWKKPTYDG 15969

Query: 794   GADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRLQAFNQAG------ 844
             G+ I+ Y +E  E  E   +    T   DT FE+  L+   +Y  R+ A N AG      
Sbjct: 15970 GSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPS 16029

Query: 845   --AGPYSELVLCQTPASAPDP--VSTLCVLEEEPL----DAYPDSPSACLVLNWEEPCNN 896
                G  +       P  + DP    T+ V   E      D Y         +  ++  +N
Sbjct: 16030 ESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN 16089

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
              + +   + D   TS++V        KD +   +    ++A N  G    +  +K   RP
Sbjct: 16090 TARLEIKSTDFA-TSLSV--------KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 16140

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY- 1015
              PP  P +  +    +   L W     +   ++ I Y ++  + ++   ++      T  
Sbjct: 16141 GPPEGP-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLS 16198

Query: 1016  -KVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
              KV +L E   Y+FRI A ++ G G    SE         VP   KAP VT +  +S  +
Sbjct: 16199 CKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIV 16258

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACR 1129
             +WE   S  G  +  Y+L+        + + +K    E   +++GL  N DY FRV A  
Sbjct: 16259 VWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA-- 16316

Query: 1130  RCLDTSQELSGAFSPSA 1146
                + +  LS    PSA
Sbjct: 16317 ---ENAAGLSEPSPPSA 16330



 Score =  156 bits (395), Expect = 1e-37
 Identities = 223/898 (24%), Positives = 352/898 (39%), Gaps = 90/898 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS++ A + VLSW  P         G +   +Y V   + G      +  S +  +  +
Sbjct: 22252 EVSSVSAESCVLSWGEP------KDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKV 22305

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L    +Y  RV +   +   K   S P+        P  P  P++ H S ++++++W+
Sbjct: 22306 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22365

Query: 401   API-DNGSKITNYLLEWDEGKRNSGFRQ----CFFGSQKHCKLTKLCPAMGYTFRLAARN 455
              P  D GSKI  Y +E  E       ++    C    + + K+T L   + Y FR  A N
Sbjct: 22366 EPYHDGGSKIIGYWVEKKERNTILWVKENKVPCL---ECNYKVTGLVEGLEYQFRTYALN 22422

Query: 456   DIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE--- 512
               G S  S+        N    P  P +     + V+L WS P      +V+ Y +E   
Sbjct: 22423 AAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKP 22482

Query: 513   IQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPSEVLVCTTSPD 570
             + E  +       YT   D   TV  L     Y+FR+ A N  G  S  SE     T  D
Sbjct: 22483 VSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRD 22542

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKD------NGGSEILKYLLEITDGNSEANQWE-- 622
                PP   L       HG  V      D       GG    K +   T G+ E +  E  
Sbjct: 22543 EYAPPKAEL---DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIW--TKGDKELDLCEKV 22597

Query: 623   -VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
              + Y+G                K      +  G    + S+ V+ L  +PG C    V  
Sbjct: 22598 SLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTK--AVSVMVKVLD-SPGPCGKLTV-S 22653

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG--PELECTVGNLLPGTVY 739
             R   ++  L W +P  + G E++ Y VE  E   +   +  G  P L   V  L+    Y
Sbjct: 22654 RVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22713

Query: 740   RFRVRALNDGGYGPYSDVSEIT-----TAAGPPGQCKAPCISCTPDGCVLVGWESPDSSG 794
              FRVRA+N  G G   +   I      T   PPG    P    T    +++ W  P+S G
Sbjct: 22714 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG---IPEEVGTGKEHIIIQWTKPESDG 22770

Query: 795   A-DISEYRLEWGEDEE----SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
               +IS Y ++  E +      +   Y   DTR ++  L+    Y  R+ A N AG    S
Sbjct: 22771 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22830

Query: 850   E---LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTI 905
             E    + C+ P+  P P S   V+         D+    + L W +P  + G++I+ Y +
Sbjct: 22831 EASNFISCREPSYTPGPPSAPRVV---------DTTKHSISLAWTKPMYDGGTDIVGYVL 22881

Query: 906   DLGD----------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR 955
             ++ +          T+ T+ NT   V  DL     Y  R+ A+N  G   +S+ I A+  
Sbjct: 22882 EMQEKDTDQWYRVHTNATIRNTEFTV-PDLKMGQKYSFRVAAVNVKGMSEYSESI-AEIE 22939

Query: 956   PLPPLP-PRLECAAAGPQSLKLKWGDS-----NSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
             P+  +  P LE A    +++ ++ G S     +        I ++ Q  D   R I    
Sbjct: 22940 PVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTT 22999

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                    V ++  +    + I+A +++G+   +       T    P++K   V++   +S
Sbjct: 23000 ESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR---DS 23056

Query: 1070  CEILWETVPSMKGDPV-NYILQVLVGRESEYKQV-YKGEEATFQISGLQTNTDYRFRV 1125
               I WE      G PV NYI++        +K V  K  +  ++ISGL   T Y FRV
Sbjct: 23057 VTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23114



 Score =  151 bits (382), Expect = 3e-36
 Identities = 213/899 (23%), Positives = 335/899 (37%), Gaps = 85/899 (9%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE--- 337
             +P+V ++ A A+ + W  P       H G S    Y V   ++       I++  E    
Sbjct: 22349 RPEVYHVSANAMSIRWEEPY------HDGGSKIIGYWVEKKERNT-----ILWVKENKVP 22397

Query: 338   -LECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSS 394
              LECN K   L    +Y  R YA+  +     SE           + P  P++   ++S+
Sbjct: 22398 CLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST 22457

Query: 395   LTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFR--QCFFG--SQKHCKLTKLCPAMGYTF 449
             ++L W AP  D GSK+  Y++E          R  +C +   S     +T L     Y F
Sbjct: 22458 VSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEF 22517

Query: 450   RLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPRL------VRAGITWVTLQWSKPE 499
             R+ A+N  G      E    V C      P+     RL      +RAG   V        
Sbjct: 22518 RVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVL---DAAV 22574

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             G  PE  I +T   +E +       +YTG+  T  +K   RS   K+ LT  N  G    
Sbjct: 22575 GGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAV 22634

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
             S ++    SP     P   L    VT    ++ W  P+++GG+EI  Y++E  +  S  N
Sbjct: 22635 SVMVKVLDSPG----PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRE-TSRLN 22689

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPP 677
                V        Y  T L     Y  R   ++  G     ES P+  R     P     P
Sbjct: 22690 WVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIP 22749

Query: 678   RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTVGNL 733
               +G  K + + ++W  P S+ G E+S Y V+  E + +     ++ Y   +    V +L
Sbjct: 22750 EEVGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSL 22808

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESP 790
             + G  Y+FRV A+N  G    S+ S   +   P   PG   AP +  T    + + W  P
Sbjct: 22809 MEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKP 22868

Query: 791   -DSSGADISEYRLEWGEDEESLELIYHGT----DTRFEIRDLLPAAQYCCRLQAFNQAGA 845
                 G DI  Y LE  E +       H      +T F + DL    +Y  R+ A N  G 
Sbjct: 22869 MYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGM 22928

Query: 846   GPYSELVLCQTPAS---------APDPVSTLCVLEEEPLDAYPD-SPSACLVLNWEEPCN 895
               YSE +    P           A D   T+ +     L      S     V+ W +   
Sbjct: 22929 SEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSK--- 22985

Query: 896   NGSEILAYTIDLGDTSI--TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                      IDL   +I  T  + ++ ++  +      +  I+A N+ G    +  +K  
Sbjct: 22986 -------QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVY 23038

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH 1013
               P P   P ++       S+ + W        A  +     + E   + F ++    S 
Sbjct: 23039 DTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK 23096

Query: 1014  T-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T Y++  L E T Y FR+   +  G G   ET        VP       V  +  ++  +
Sbjct: 23097 TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTL 23156

Query: 1073  LWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQ--ISGLQTNTDYRFRVCA 1127
              WE  P   G      Y+L+        + +V   +    +  ++ L     Y FR+ A
Sbjct: 23157 AWEK-PLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 23214



 Score =  151 bits (381), Expect = 4e-36
 Identities = 204/888 (22%), Positives = 355/888 (39%), Gaps = 68/888 (7%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P V+N+   ++ + W  PV       +G S    Y + + D+         K++      
Sbjct: 20179 PWVTNVTRESITVGWHEPVS------NGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHF 20232

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  +  +     Y  RVYA   +  G  S P        A E P   ++   SK+S++L 
Sbjct: 20233 K--VTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLS 20290

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W+ P  D GSKIT Y++E  +       +  F   ++    ++ L     Y FR+ ARN 
Sbjct: 20291 WQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNA 20350

Query: 457   IGTSGYSQEVV----CYTL--GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYT 510
             +G+     EVV    C     G +  +P     V       +++        P   I + 
Sbjct: 20351 VGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 20410

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
              + +E + + L   + T +  +  +K+  R     + L   N  G +  +   +     D
Sbjct: 20411 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT---IRVQILD 20467

Query: 571   RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
             +PGPP  P+    VT+   ++ W PP D+GG++I  Y++E  +  S      V+      
Sbjct: 20468 KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRE-TSRVVWSMVSEHLEEC 20526

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQC--SESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
               T T +  G  Y  R   ++  G  +   S+S+  +   + PG    P V    K+  +
Sbjct: 20527 IITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKN-SM 20585

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPGTVYRFRV 743
              + W  P ++ G ++S Y +E  + +      V  E       + T   L   + Y++RV
Sbjct: 20586 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVT--GLTENSDYQYRV 20643

Query: 744   RALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISE 799
              A+N  G GP+S+ SE   AA    PPG      I+ +    + +GW  P    G+ ++ 
Sbjct: 20644 CAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTG 20703

Query: 800   YRLE--WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAGAG---PYSELV 852
             Y +E   GE+EE   +   G    T + + +L P   Y  R+ A N AG G     +E V
Sbjct: 20704 YVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPV 20763

Query: 853   LCQTPASAPD-------PVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
               +    AP+         S +    E+     P        + W +   N      Y+I
Sbjct: 20764 QAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSI 20823

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             +  D+S      ++  +  +    T +  +   N +G  P S  +  K    P    +L+
Sbjct: 20824 ENTDSS------SLLTIPQVTRNDTGKYILTIENGVGE-PKSSTVSVKVLDTPAACQKLQ 20876

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI--YRGPSHTYKVQRLTEF 1023
                    ++ L W D       +  I Y ++  D  KR  S+  ++  S ++K+  L+E 
Sbjct: 20877 VKHVSRGTVTLLW-DPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 20935

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             T + FR+ A +E G G   ET        VP  I+   +      S  + W T P   G 
Sbjct: 20936 TPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW-TKPDFDGG 20994

Query: 1084  PVNYILQVLVGRESEYKQVYK----GEEATFQISGLQTNTDYRFRVCA 1127
              V  I + +V R+ + +Q +      +    ++S L+  +   FRV A
Sbjct: 20995 SV--ITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFA 21040



 Score =  147 bits (372), Expect = 5e-35
 Identities = 194/806 (24%), Positives = 311/806 (38%), Gaps = 94/806 (11%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++S+TLQWK P  D GSKIT Y++E  E       +  F      
Sbjct: 15942 CDP--PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDT 15999

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQE----VVCYTLGNIPQMPSAPR-----LVR 485
             H ++T L     Y FR+ ARN  G      E    +      + P++   P+     +V 
Sbjct: 16000 HFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH 16059

Query: 486   AGITWV-----------TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG ++            T+QW K +              QE  N      K T    + +
Sbjct: 16060 AGESFKVDADIYGKPIPTIQWIKGD--------------QELSNTARLEIKSTDFATSLS 16105

Query: 535   VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD 594
             VK+  R     + L A N  G+     V V     DRPGPP  P+V   VT+   ++ W 
Sbjct: 16106 VKDAVRVDSGNYILKAKNVAGER---SVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWK 16162

Query: 595   PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT-EYTFTHLKPGTLYKLRACCISTG 653
             PP  +GGS+I+ Y++E  + +     W V  +   T     T L  G  Y  R   ++  
Sbjct: 16163 PPLQDGGSDIINYIVERRETSRLV--WTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKY 16220

Query: 654   GHSQCSESLPV--RTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV  +   + P   + P V    K   + + W+ PAS+ G E+  Y +E  
Sbjct: 16221 GVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI-VVWERPASDGGSEILGYVLEKR 16279

Query: 712   EPEDVASEVYHGP---ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP-- 766
             + E +     H     EL   V  L+    Y FRV A N  G    S  S    A  P  
Sbjct: 16280 DKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 16339

Query: 767   -PGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE---DEESLELIYHGTD-T 820
              PG    P +       V + W  P    G +I  Y +E  +    E ++     G + T
Sbjct: 16340 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 16399

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
               E+  LL   +Y  R+ A N+AG G ++++   ++ +    APD    L + +   + A
Sbjct: 16400 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRA 16459

Query: 878   -------YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT 930
                     P        + W +      +     +    TS+ + N   +          
Sbjct: 16460 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRY------DSGK 16513

Query: 931   YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSK 984
             Y + +    E  +G  S F+  +    P  P  L+       S+ + W      G S  K
Sbjct: 16514 YTLTL----ENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16569

Query: 985   THAAEDIVYTLQLEDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              +  E      + E   K + ++      +++K+ +L E   Y FR+ A +E G G  ++
Sbjct: 16570 NYIVE------KREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQ 16623

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQ 1101
             T        VP       V  +  NS  + W T P   G    + YI+++      ++ +
Sbjct: 16624 TADPIKVAEVPQPPGKITVDDVTRNSVSLSW-TKPEHDGGSKIIQYIVEMQAKHSEKWSE 16682

Query: 1102  VYKGEEATFQISGLQTNTDYRFRVCA 1127
               + +     I+ L    +Y FRV A
Sbjct: 16683 CARVKSLQAVITNLTQGEEYLFRVVA 16708



 Score =  147 bits (372), Expect = 5e-35
 Identities = 204/794 (25%), Positives = 309/794 (38%), Gaps = 69/794 (8%)

Query: 377   CAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QK 434
             C P  P  P+    +++++TL+WK P  D GSKIT Y++E  +       +  F    + 
Sbjct: 18106 CDP--PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLET 18163

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVR 485
                ++ L     Y FR+ ARN  G     S  S  +      + P     P+     +V 
Sbjct: 18164 EFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVH 18223

Query: 486   AGITWVT-----------LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
             AG T+V            + WSK +G   EE     +EI           K T +  T  
Sbjct: 18224 AGETFVLEADIRGKPIPDVVWSK-DGKELEETAA-RMEI-----------KSTIQKTTLV 18270

Query: 535   VKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             VK+  R+   ++ L  SN  G KS P  V V     DRPGPP  PL    VT+    + W
Sbjct: 18271 VKDCIRTDGGQYILKLSNVGGTKSIPITVKVL----DRPGPPEGPLKVTGVTAEKCYLAW 18326

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTG 653
             +PP  +GG+ I  Y++E  +  S  +  +V+    A  Y  T L PG  Y  R   ++  
Sbjct: 18327 NPPLQDGGANISHYIIEKRE-TSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18385

Query: 654   GHSQCSESLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
             G  +  ES PV   +    PG    P V    K   V + W  P  + G E+  Y +E  
Sbjct: 18386 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMV-VTWARPVDDGGTEIEGYILEKR 18444

Query: 712   EPEDVASEVYHG---PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG--- 765
             + E V     +     +L   V  L  G  Y FRV A N  G G  S+ S    A     
Sbjct: 18445 DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALY 18504

Query: 766   PPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGE---DEESLELIYHGTD-T 820
             PPG    P ++ T    V + W  P    GA +  Y +E  E   DE +      G    
Sbjct: 18505 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGK 18564

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLCVLEEEPLDA 877
             +F +  L    +Y  R+ A N  G G  + L   V+ Q     P+      + +   L A
Sbjct: 18565 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 18624

Query: 878   YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQA 937
                      +    EP     +      D     +T  + TM V+ ++    + R  +  
Sbjct: 18625 SATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-SSFTMLVIDNVTRFDSGRYNLTL 18683

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQL 997
              N   +G  + F+  +    P  P  L        S+ L W        A        + 
Sbjct: 18684 EN--NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 18741

Query: 998   EDRNKRFISIYRG-PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT 1056
             E   K + +I       T++++ L E   Y FR+ A++E G G  +E  T    K   P 
Sbjct: 18742 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAE--TTEPVKVSEPP 18799

Query: 1057  IKAPRVTQLE--GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQIS 1113
             +   RVT ++   N+  I WE   S  G  +  Y++++      ++    + +     IS
Sbjct: 18800 LPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATIS 18859

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y FRV A
Sbjct: 18860 GLTAGEEYVFRVAA 18873



 Score =  146 bits (368), Expect = 1e-34
 Identities = 220/960 (22%), Positives = 387/960 (40%), Gaps = 137/960 (14%)

Query: 249   RRARSSPKSNDSDLQEYELEVKRVQD------ILSGIEKP------QVSNIQARAVVLSW 296
             R + +   +N +D  +Y L ++ V        ++  ++ P       V ++   + VLSW
Sbjct: 19742 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 19801

Query: 297   APPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVY 356
               P      P        +Y +   +  +     +  +   L   + +L+    Y+ RV 
Sbjct: 19802 DVPENDGGAPVK------NYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVS 19855

Query: 357   AMYN---SVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKI 409
                     +     E V  T      E P PP+   +   SK S++L W  P  D GS+I
Sbjct: 19856 GENEFGVGIPAETKEGVKIT------EKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRI 19909

Query: 410   TNYLLE-WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVC 468
              +Y++E  ++G++N  + +C      H  ++ L     Y FR+ A N  G S   + ++ 
Sbjct: 19910 VHYVVEALEKGQKN--WVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLP 19967

Query: 469   YTLG--------NIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
               +         ++   PS    VRAG     L+   P    P   +T + +    +   
Sbjct: 19968 VLIKEQLEPPEIDMKNFPSHTVYVRAGSN---LKVDIPISGKPLPKVTLSRDGVPLKATM 20024

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLV 580
              F+ + T E+LT  +K    +   ++ +TA+N+ G +   +  +     DRPGPPT P+V
Sbjct: 20025 RFNTEITAENLTINLKESVTADAGRYEITAANSSGTT---KAFINIVVLDRPGPPTGPVV 20081

Query: 581   KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPG 640
                +T    ++KW+PPK +GGS++  Y+L +    S A   EV+ + + T      L  G
Sbjct: 20082 ISDITEESVTLKWEPPKYDGGSQVTNYIL-LKRETSTAVWTEVSATVARTMMKVMKLTTG 20140

Query: 641   TLYKLRACCISTGGHSQCSES--LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
               Y+ R    +  G S   +S  + V+     PG    P V    + + + + W  P S 
Sbjct: 20141 EEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTR-ESITVGWHEPVSN 20199

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDGGYGPYS 755
              G  V  Y +EM +   +  +  +   +  T   V  +  G +Y FRV A N  G G  S
Sbjct: 20200 GGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 20259

Query: 756   DVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEY---RLEWGEDE 808
               SE      A  PP   +   IS      V + W+ P    G+ I+ Y   R +  +  
Sbjct: 20260 HPSEPVLAIDACEPPRNVRITDIS---KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGR 20316

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL- 867
              +     + T+T+F I  L   +QY  R+ A N  G+           P+    P++ + 
Sbjct: 20317 WTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGS--------ISNPSEVVGPITCID 20368

Query: 868   --------CVLEEEPLDAYPDSPSACL----------VLNW----EEPCNNGSEILAYTI 905
                       LE   +  Y    S  L           + W    +E   N    +  T 
Sbjct: 20369 SYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTT 20428

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
             DL   SI + +       D L    Y ++++  N +G+   +  ++   +P PP  P +E
Sbjct: 20429 DL--ASILIKDA------DRLNSGCYELKLR--NAMGSASATIRVQILDKPGPPGGP-IE 20477

Query: 966   CAAAGPQSLKLKW----GDSNSK-TH------AAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
                   + + L W     D  +K TH          +V+++  E   +  I+       T
Sbjct: 20478 FKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIIT-------T 20530

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV----PPTIKAPRVTQLEGNSC 1070
              K+ +  E   Y FR++A ++ G G   E+ +     +     PP I  P VT++  NS 
Sbjct: 20531 TKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI--PEVTKITKNSM 20585

Query: 1071  EILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              ++W    +  G  ++ Y L+    +   + +V K    +   +++GL  N+DY++RVCA
Sbjct: 20586 TVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCA 20645



 Score =  145 bits (366), Expect = 2e-34
 Identities = 219/898 (24%), Positives = 343/898 (38%), Gaps = 89/898 (9%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             + P +SNI    + +SW PP      P +G         A++    + K  I     E  
Sbjct: 12995 DPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-----ERT 13049

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPEC----PFPPKLAHRSKSSL 395
                  L+  T+Y  RV A+  +  G  S+  S   ++  P+     P  PK+   ++SS+
Sbjct: 13050 LKATGLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13108

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG---SQKHCKLTKLCPAMGYTFRL 451
             +L W  P  D GS I  YL+E      ++  R C       +   ++T L     Y FR+
Sbjct: 13109 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR-CNLPQNLQKTRFEVTGLMEDTQYQFRV 13167

Query: 452   AARNDIGTSG--------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
              A N IG S         Y ++++    G +        ++RAG   VT++   P    P
Sbjct: 13168 YAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG---VTMRLYVPVKGRP 13224

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVL 563
                IT++       +      K T  D     +N+ +    K+ LT  N+ GK    E  
Sbjct: 13225 PPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGK---KEYT 13281

Query: 564   VCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE- 622
             +     D PGPP    VK  ++     V W+PP  +GGS I+ Y+++  D  +E   W  
Sbjct: 13282 IVVKVLDTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRD--AERKSWST 13338

Query: 623   VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             V    S T +   +L+ G  Y  R    +  G     E+      S  PG     +V   
Sbjct: 13339 VTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSV 13398

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
              K     + W  P S+ G  +  Y V+    E+    V     L+ +  +L  G  Y FR
Sbjct: 13399 SK-SSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFR 13457

Query: 743   VRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS---E 799
             V A N+ G G     SEIT  A          +   PD C L    S       I     
Sbjct: 13458 VSAENENGEG---TPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPA 13514

Query: 800   YRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPAS 859
               + W + E+ L      TDTR  +     A      +    ++ AG Y+  +  +  A 
Sbjct: 13515 PSVSWKKGEDPL-----ATDTRVSVES--SAVNTTLIVYDCQKSDAGKYT--ITLKNVAG 13565

Query: 860   APDPVSTLCVLEEEPLDAYP----DSPSACLVLNWEEPCNN-GSEILAYTIDLGDT---- 910
               +   ++ V+ +  +   P    +  +  + L W  P ++ GSEI  Y ++  D+    
Sbjct: 13566 TKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNK 13625

Query: 911   ----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG---PFSQFIKAKTRPLPPLPPR 963
                 +  V  TT  V + L     Y  R+ A N+ G G        +      +P  PP 
Sbjct: 13626 WVTCASAVQKTTFRVTR-LHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPP 13684

Query: 964   LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT------YKV 1017
                      S+ L W D   KT  +    Y L+ ++RN     +++  + T      +KV
Sbjct: 13685 PNIVDVRHDSVSLTWTDP-KKTGGSPITGYHLEFKERNS---LLWKRANKTPIRMRDFKV 13740

Query: 1018  QRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWET 1076
               LTE   Y FR+ A + AG G P   +        + P  K P V  +  NS  ++W T
Sbjct: 13741 TGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK-PEVINITRNSVTLIW-T 13798

Query: 1077  VPSMKGDP--VNYILQVLVGRESEYKQVYKGE-----EATFQISGLQTNTDYRFRVCA 1127
              P   G      YI++    R+   K   K       E  F ++ L     Y FR+ A
Sbjct: 13799 EPKYDGGHKLTGYIVE---KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRA 13853



 Score =  145 bits (366), Expect = 2e-34
 Identities = 216/907 (23%), Positives = 353/907 (38%), Gaps = 111/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR---DGKYKIIYSGEEL 338
             P+V +     ++++W  PV      + G S    Y +   ++         KI+ +  ++
Sbjct: 19096 PKVVHATKSTMLVTWQVPV------NDGGSRVIGYHLEYKERSSILWSKANKILIADTQM 19149

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCS---EPVSFTTHSCAPECPFPPKLAHRSKSSL 395
             +  +  L     Y  RVYA   +  G CS   EPV      C P  P  P++ + ++ S+
Sbjct: 19150 K--VSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDP--PGQPEVTNITRKSV 19204

Query: 396   TLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYTFRLAA 453
             +L+W  P  D G+KIT Y++E  E       +  +   Q+ + ++T+L     Y FR+ A
Sbjct: 19205 SLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFA 19264

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGITWVTLQWSKPEGCS 502
             RN   +     E     +      P  PR+           V+AG     L+ +      
Sbjct: 19265 RNAADSVSEPSESTGPIIVKDDVEP--PRVMMDVKFRDVIVVKAG---EVLKINADIAGR 19319

Query: 503   PEEVITYT---LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
             P  VI++    +EI+E     +     T      TVK+  R    ++ LT  N  G    
Sbjct: 19320 PLPVISWAKDGIEIEERARTEIIS---TDNHTLLTVKDCIRRDTGQYVLTLKNVAGTR-- 19374

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V V     D+PGPP  PL    +T+   S+ W  P+++GG++I  Y++E  + +  A 
Sbjct: 19375 -SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLA- 19432

Query: 620   QWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
              W +       T    T L  G  Y  R   ++  G  +  ES+ ++ L        P  
Sbjct: 19433 -WTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTS 19491

Query: 679   VLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDV------ASEVYHGPELECTVG 731
             +      KE + L W  P S+ G E+S Y +E  E   +         VY   +L     
Sbjct: 19492 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVY---DLRVKST 19548

Query: 732   NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWE 788
              L  G  Y +RV A N  G    S+ S +  A  P   P     P I  +    + + W 
Sbjct: 19549 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWV 19608

Query: 789   SP-DSSGADISEYRLEW--GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGA 845
              P    GA I+ Y +E+   +D +    I     T + I  L   A+Y  R+++ N+ GA
Sbjct: 19609 KPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 19668

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN---------------- 889
                        P+ + DP       EEEPL          L++                 
Sbjct: 19669 ---------SDPSDSSDP-QIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPV 19718

Query: 890   ----WEEPCNNGSEILAYTIDLGD--TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
                 W +P +      AY +D  D  TS+T+ N   +          Y + IQ  N + A
Sbjct: 19719 PNVLWSKP-DTDLRTRAY-VDTTDSRTSLTIENANRN------DSGKYTLTIQ--NVLSA 19768

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
                +  +K    P P  P  +       +S  L W    +   A     +  + E   K 
Sbjct: 19769 ASLTLVVKVLDTPGP--PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKA 19826

Query: 1004  FISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRV 1062
             ++S+    +  +YKV  L E   Y FR+   +E G G  +ET         P   +   V
Sbjct: 19827 WVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGV 19886

Query: 1063  TQLEGNSCEILWETVPSMKGDP--VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             T +  +S  + W   P   G    V+Y+++ L   +  + +    +     +SGL+ N++
Sbjct: 19887 TSISKDSVSLTW-LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSE 19945

Query: 1121  YRFRVCA 1127
             Y FRV A
Sbjct: 19946 YFFRVFA 19952



 Score =  145 bits (365), Expect = 3e-34
 Identities = 217/907 (23%), Positives = 339/907 (37%), Gaps = 109/907 (12%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG------ 335
             P  + I   ++V+ W  PV     P  G    Y  E       R  +  I+++       
Sbjct: 16932 PFATAISKDSMVIQWHEPVNNGGSPVIG----YHLE-------RKERNSILWTKVNKTII 16980

Query: 336   EELECNLKDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
              + +   ++L    +Y  RVYA  +    K S +         C P  P  P+     ++
Sbjct: 16981 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRN 17038

Query: 394   SLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRL 451
              +TLQW  P+ D GS IT Y++E  +       +  F    +    ++ L     Y FR+
Sbjct: 17039 EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17098

Query: 452   AARNDIGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITWVTLQWSKPEGCS 502
              A+N  G     S  +  +       +P++   P+     +V AG T+   +        
Sbjct: 17099 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETF---RLEADVHGK 17155

Query: 503   PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSE 561
             P   I +    +E E       K T       VK+  R    ++ L ASN  G KS P  
Sbjct: 17156 PLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVN 17215

Query: 562   VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
             V V     DRPGPP  P+    VTS   S+ W PP  +GGS+I  Y++E  + +  A  W
Sbjct: 17216 VKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLA--W 17269

Query: 622   EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPR 678
              V  S   T     T L  G  Y  R   ++  G  +  ES PV  +   + PG  +   
Sbjct: 17270 TVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLE 17329

Query: 679   VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA---SEVYHGPELECTVGNLLP 735
             V    K   + + W+ P S+ G E+  Y VE  +   +           +L   V  L  
Sbjct: 17330 VTNIAKDS-MTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTE 17388

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISCTPDGCVLVGWESPD- 791
                Y FRV A N  G G  S  +    A  P   PG      I  T    + + W  P  
Sbjct: 17389 DHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIY 17448

Query: 792   SSGADISEYRLEWGE-DEESLELIYHGTD---TRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
               G++I  Y +E  + DEE  +++   T    TRFEI  L    +Y  R+ A N+ G G 
Sbjct: 17449 DGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE 17508

Query: 848   YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-------------------L 888
              +         S P  V     LE   LD   +     +V                   +
Sbjct: 17509 AT---------SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEI 17559

Query: 889   NWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
              W       ++ +     +  T +++ N       D      Y +++    E  +G  S 
Sbjct: 17560 TWSREEGEFTDKVQIEKGVNYTQLSIDNC------DRNDAGKYILKL----ENSSGSKSA 17609

Query: 949   FIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNK 1002
             F+  K    P  P  L        S  L W      G +  K +  +      + E   K
Sbjct: 17610 FVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID------KRESTRK 17663

Query: 1003  RFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR 1061
              + ++    S T +KV+ LTE   Y FR+ A +E G G   ET         P       
Sbjct: 17664 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17723

Query: 1062  VTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
             +T +   S  ++WE      G  V  Y++++      ++  V + +     ++GL +  +
Sbjct: 17724 LTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQE 17783

Query: 1121  YRFRVCA 1127
             Y+FRV A
Sbjct: 17784 YQFRVKA 17790



 Score =  145 bits (365), Expect = 3e-34
 Identities = 190/781 (24%), Positives = 303/781 (38%), Gaps = 90/781 (11%)

Query: 361   SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEG 419
             +V G+ SE +             P K+     +S+T+ W+ P +D G+ ++ Y++E  + 
Sbjct: 23318 NVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDA 23377

Query: 420   KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVV--CYTLGNIPQM 477
              R          ++   K T+L     Y FR+AA N  G   Y Q  V  C +   IP  
Sbjct: 23378 HRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 23437

Query: 478   PSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT-CTVK 536
             P   ++       +TL W  PE     +V  Y +E +E   D           +T     
Sbjct: 23438 PETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRST 23497

Query: 537   NLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
              L    +Y+ R+TA N  G    S PS+ +V       PG P  P V    T    S+ W
Sbjct: 23498 GLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVT-DTTRTSVSLAW 23556

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYS--GSATEYTFTHLKPGTLYKLRACCIS 651
               P+D GGS++  YL+E+     + ++W    +      EYT THL  G  Y+ R    +
Sbjct: 23557 SVPEDEGGSKVTGYLIEMQ--KVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACN 23614

Query: 652   TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDVPASESGCEVSEYSVEM 710
              GG  + +E          PG  +   +L  P ++ +   +  +   + G  V   ++ +
Sbjct: 23615 AGGPGEPAE---------VPGTVKVTEMLEYPDYELDERYQEGIFVRQGG--VIRLTIPI 23663

Query: 711   T-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---------- 759
               +P  +      G ++          T     ++  + G  G Y  V E          
Sbjct: 23664 KGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYI 23723

Query: 760   ----ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELI 814
                 I +   P G  +   I       V V W  P D  GADI  Y L   E  E  +  
Sbjct: 23724 KVRVIGSPNSPEGPLEYDDIQVR---SVRVSWRPPADDGGADILGYIL---ERREVPKAA 23777

Query: 815   YHGTDTRFE-----IRDLLPAAQYCCRLQAFNQAGAG---PYSELVLCQTPASAPDPVST 866
             ++  D+R       ++ L    +Y  R+ A NQ G        E V  +TP + P+P S 
Sbjct: 23778 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSN 23837

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTSI--------TVGNT 917
                   E LD    S S    L+W  P ++ GS +  Y I+  +TS         T   T
Sbjct: 23838 ----PPEVLDVTKSSVS----LSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 23889

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTR-PLPPLPPRLECAAAGPQS 973
             TM+ +  L+P+  Y+ RI A N++G     P S+ +  K     P  P  LE  +    S
Sbjct: 23890 TMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDS 23949

Query: 974   LKLKWGDSNSKTHAAEDI----VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
             + L+W     +    ++I    V   Q  D   +  +  R     + +  L E T Y FR
Sbjct: 23950 VTLQW--EKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFR 24007

Query: 1030  IQAASEAG-EGPFSETYTFST--TKSVPPTIK------APRVTQLEGNSCEILWETVPSM 1080
             + A +E G   P     +  T  T    P I+        ++ +    SC+I+   +P +
Sbjct: 24008 VFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDI 24067

Query: 1081  K 1081
             K
Sbjct: 24068 K 24068



 Score =  144 bits (363), Expect = 5e-34
 Identities = 208/860 (24%), Positives = 341/860 (39%), Gaps = 95/860 (11%)

Query: 350   DYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSK 408
             +Y  R+YA+  +     S+P  + T     + P  P++   +KS+++L W  P  D GSK
Sbjct: 12664 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 12723

Query: 409   ITNYLLE-----WDEGKR-NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGY 462
             I  Y +E      D+  R N+   Q     Q+    T L     Y FR  AR  +  S  
Sbjct: 12724 IIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEEKAQYQFRAIARTAVNISPP 12780

Query: 463   SQ--EVVCYTLGNIPQMPSAPRL-VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND 519
             S+  + V     N+P     PR+ +   +  +    +    C    V    +     + D
Sbjct: 12781 SEPSDPVTILAENVP-----PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 12835

Query: 520   N-LFHP----KYTGEDLTCTVK--NLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDR 571
               L  P    K   +   CT++  ++ R     + +TA N+ G KS   ++ V     D+
Sbjct: 12836 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL----DK 12891

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP    +    +     + W+PP ++GGSEI  Y+++  +  S  N  +V+ +   T 
Sbjct: 12892 PGPPASVKINKMYSDRAM-LSWEPPLEDGGSEITNYIVDKRE-TSRPNWAQVSATVPITS 12949

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH 689
              +   L  G  Y+ R C  +  G      +E    +     PG+C PP V+       + 
Sbjct: 12950 CSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPP-VISNITKDHMT 13008

Query: 690   LEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECTVG--NLLPGTVYRFRVRAL 746
             + W  PA + G  ++ Y +E  E + V  ++V   P +E T+    L  GT Y FRV A+
Sbjct: 13009 VSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAI 13068

Query: 747   NDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL 802
             N  G G  SD S+   A     PPG    P +  T    V + W  P    G+ I  Y +
Sbjct: 13069 NKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLV 13128

Query: 803   EWGEDEES----LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
             E    +        L  +   TRFE+  L+   QY  R+ A N+ G   YS+      P+
Sbjct: 13129 EVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG---YSD------PS 13179

Query: 859   SAPDP--VSTLCVLEEEPLDA-----------------YPDSPSACLVLNWEEPCNNGSE 899
               PD      + +  E  LDA                  P        + W +P  N  +
Sbjct: 13180 DVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD 13239

Query: 900   ILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
              +   +D+  T         +V K       Y + ++  N  G   ++  +K    P PP
Sbjct: 13240 RIG--LDIKSTDFDTFLRCENVNK--YDAGKYILTLE--NSCGKKEYTIVVKVLDTPGPP 13293

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED-RNKRFISIYRGPSHT-YKV 1017
             +   +        S  + W +       +  I Y +Q  D   K + ++    S T ++V
Sbjct: 13294 V--NVTVKEISKDSAYVTW-EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRV 13350

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETV 1077
               L E   Y FR+ A +E G G   ET         P  +   +V  +  +SC I W+  
Sbjct: 13351 ANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKP 13410

Query: 1078  PSMKGDP-VNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQ 1136
              S  G   + Y++  L   E+++++V K     +    L    +Y FRV A        +
Sbjct: 13411 HSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA--------E 13461

Query: 1137  ELSGAFSPSAAFVLQRSEVM 1156
               +G  +PS   V+ R +V+
Sbjct: 13462 NENGEGTPSEITVVARDDVV 13481



 Score =  144 bits (363), Expect = 5e-34
 Identities = 211/906 (23%), Positives = 353/906 (38%), Gaps = 106/906 (11%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKII---YSGEE 337
             KP + N+ +  + L+W  PV      + G S    + V   ++      K+     SG E
Sbjct: 21265 KPVIYNVTSDGMSLTWDAPV------YDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 21318

Query: 338   LECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTL 397
                    L    DY  RVYA  ++   S S+P  FT      + P  P     ++ ++TL
Sbjct: 21319 YRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITL 21376

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
             +W  P+ D GSKI  Y +E  +G  N  + +C F     C+  +T L P   Y FR+ AR
Sbjct: 21377 KWNPPLRDGGSKIVGYSIEKRQG--NERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIAR 21434

Query: 455   NDIGT---SGYSQEVVCYTLGNIPQMPS-APR-----LVRAGITWVTLQWSKPEGCSPEE 505
             N +GT      S  ++     N+P +    P      ++++G +      +  +G     
Sbjct: 21435 NAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIK--ALVQGRPVPR 21492

Query: 506   VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             V  +   ++ ++  N+      G   +  V++  R  +  + + A N  G S  +E+ V 
Sbjct: 21493 VTWFKDGVEIEKRMNMEITDVLGST-SLFVRDATRDHRGVYTVEAKNASG-SAKAEIKVK 21550

Query: 566   TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VA 624
                 D PG    P+    +T    ++ WD P ++G + I  Y++E  + +  A  W  + 
Sbjct: 21551 VQ--DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLA--WALIE 21606

Query: 625   YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV-----RTLSIAPGQCRPPRV 679
                 A  YT   L  G  Y+ R   ++  G  +  +S PV      T+  APG   P  +
Sbjct: 21607 DKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI 21666

Query: 680   LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDV--ASEVYHGP--ELECTVGNLLP 735
              G      + L W  P S+ G E+ +Y +E  E +       +   P  E    V  L  
Sbjct: 21667 TG----NSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTE 21722

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESP-D 791
             G  Y F V A N  G GP S +S +        PPG      ++ T    V + W  P  
Sbjct: 21723 GNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVF 21782

Query: 792   SSGADISEYRLEWGEDEESLELIYHGTD------TRFEIRDLLPAAQYCCRLQAFNQAGA 845
               G +I  Y +E  + +      +H  +      TR+ + DL    +Y  R+ A N AG 
Sbjct: 21783 DGGMEIIGYIIEMCKADLG---DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 21839

Query: 846   GPYSEL---VLCQTPASAPDPVSTLCVLEEEPLD---------AYPDSPSACLVLNWEEP 893
             G   E+   +      +AP+        +   +          AY   P+   V  W +P
Sbjct: 21840 GDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAV--WSKP 21897

Query: 894   CNNGSEILAYTIDLGDT----SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
              +N    L+   D+  T    ++TV N   +          Y + ++  N  G+   +  
Sbjct: 21898 DSN----LSLRADIHTTDSFSTLTVENCNRN------DAGKYTLTVE--NNSGSKSITFT 21945

Query: 950   IKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDRNKRFI 1005
             +K    P PP P   +    G  S  L W     D  ++ H      Y ++  + ++R  
Sbjct: 21946 VKVLDTPGPPGPITFKDVTRG--SATLMWDAPLLDGGARIHH-----YVVEKREASRRSW 21998

Query: 1006  SIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRV 1062
              +   +     +KV  L E   Y FR+ A +E G G P+        T+   P  +   V
Sbjct: 21999 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLD-V 22057

Query: 1063  TQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDY 1121
                  +S  + W       G  +  Y+L++       + +    ++ TF +  L   T+Y
Sbjct: 22058 VDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEY 22117

Query: 1122  RFRVCA 1127
              FRV A
Sbjct: 22118 EFRVKA 22123



 Score =  143 bits (360), Expect = 1e-33
 Identities = 217/889 (24%), Positives = 336/889 (37%), Gaps = 142/889 (15%)

Query: 336  EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCA-----PECPFPPKLAHR 390
            E  +C++  L    +Y  RV A     K  C  PV             P  P       R
Sbjct: 8753 ERSKCDITGLLEGQEYKFRVIAKN---KFGCGPPVEIGPILAVDPLGPPTSPERLTYTER 8809

Query: 391  SKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPA 444
            +KS++TL WK P  NG S I  Y++E    KR          +++ C  T      L   
Sbjct: 8810 TKSTITLDWKEPRSNGGSPIQGYIIE----KRRHDKPDFERVNKRLCPTTSFLVENLDEH 8865

Query: 445  MGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQMPSAPRLVRA----------------- 486
              Y FR+ A N+IG S  S  + V      +P        VR                  
Sbjct: 8866 QMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADV 8925

Query: 487  -GITWVTLQWSKPEGC--SPEEVITYTLE--IQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
             G+    ++WSK E     P + +  T E   + +    L  PK   ED           
Sbjct: 8926 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED----------- 8974

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             +  + +TASN  G    +   V     DRP PP R L    + +    + WD P DNGG
Sbjct: 8975 -KGTYTVTASNRLGSVFRN---VHVEVYDRPSPP-RNLAVTDIKAESCYLTWDAPLDNGG 9029

Query: 602  SEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHS-QC- 658
            SEI  Y+++  D + +  +W EV  +     Y    L P   Y+ R   ++  G S +C 
Sbjct: 9030 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECK 9089

Query: 659  SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVA 717
            S+ + ++     PG    P+VL R K   + + W  P    G  ++ Y +E  E      
Sbjct: 9090 SDKVVIQDPYRLPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYWLEKREEGSPYW 9148

Query: 718  SEVYHGP-------ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG---PP 767
            S V   P        +E  V  LL G  Y+FR  A+N  G GP S+ S+   A     PP
Sbjct: 9149 SRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPP 9208

Query: 768  GQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGT 818
            G    P +       + +GW+ P    G+ I  Y +E        W    E  +LI   T
Sbjct: 9209 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI---T 9265

Query: 819  DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAY 878
                 + +L    +Y  R++A N+AG    S+    + PA+          ++EEP    
Sbjct: 9266 TCECVVPNLKELRKYRFRVKAVNEAGESEPSD-TTGEIPATD---------IQEEPEVFI 9315

Query: 879  PDSPSACLVLNWEEPCNNGSEILAYTIDLG---------------------------DTS 911
                  CLV      C  GS+I    +  G                           D  
Sbjct: 9316 DIGAQDCLV------CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQ 9369

Query: 912  I-TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAG 970
            + T  N+++ ++ +     T +  I A N+ G    +  +K    P PP   ++     G
Sbjct: 9370 LETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRG 9429

Query: 971  PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRI 1030
               L  K  D +        ++    ++ +    ++   G S T+ V  L     Y FR+
Sbjct: 9430 SCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG-STTFVVPDLLSEQQYFFRV 9488

Query: 1031 QAASEAGEGPFSETYTFSTTKS----VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV- 1085
            +A +  G GP  ET   +T +       P IK  ++  +  N+  + W+   +  G PV 
Sbjct: 9489 RAENRFGIGPPVETIQRTTARDPIYPPDPPIKL-KIGLITKNTVHLSWKPPKNDGGSPVT 9547

Query: 1086 NYILQVLV-----GRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
            +YI++ L       ++  ++Q  K   EE  F +  L    +Y FRV A
Sbjct: 9548 HYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9596



 Score =  142 bits (359), Expect = 1e-33
 Identities = 209/893 (23%), Positives = 365/893 (40%), Gaps = 77/893 (8%)

Query: 284  VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
            ++++   + +L+W PP         G S   +Y V       +  +K+  + ++      
Sbjct: 7295 ITDVTNESCLLTWNPP------RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKAT 7348

Query: 344  DLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L P  +Y  RV A  MY   +   + P++       P  P   + +  +K ++TL W  
Sbjct: 7349 KLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCE 7408

Query: 402  PIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHC--KLTKLCPAMGYTFRLAARNDIG 458
            P D+G S IT Y +E  +   +   R C     K    ++  L     Y FR+ A N  G
Sbjct: 7409 PDDDGGSPITGYWVERLDPDTDKWVR-CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAG 7467

Query: 459  T---SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                S  ++ ++     + P  P  P +   G T V L W+KPE     ++ +Y +E+ +
Sbjct: 7468 PGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLK 7527

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV---LVCTTSPDRP 572
               D               +  L    +Y FR+ A N  G+S PSE    ++C      P
Sbjct: 7528 TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPP 7587

Query: 573  GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
             PP R L    +T +   +KW  P+ +GGS I  Y++E  D   +  Q  V  +   T+ 
Sbjct: 7588 SPP-RWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQ-TVDTTVKDTKC 7645

Query: 633  TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPGQCRPPRVLG--RPKHKE 687
            T T L  G+LY  R    +  G S  +E   S+  +     PG   PP  L       + 
Sbjct: 7646 TVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPG---PPYALAVVDVTKRH 7702

Query: 688  VHLEWDVPASESGCEVSEYSVEMTE---PEDVASEVYHGPELECTVGNLLPGTVYRFRVR 744
            V L+W+ P ++ G  +  Y +E  E      V +    GP+    V +++ GT  +F+VR
Sbjct: 7703 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7762

Query: 745  ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC---VLVGWESPDSSGAD-ISEY 800
            A N+ G G  S+ +EI +   P      P      D     + + W+ P+ +G   I  Y
Sbjct: 7763 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 7822

Query: 801  RLEW---GEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             +E    G ++          D +F++ + ++P  +Y  R++A N  G    SE+   V+
Sbjct: 7823 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 7882

Query: 854  CQTPASAPD---PVSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
             + P   P        + V+E E L    P        ++W +   +G E+ A       
Sbjct: 7883 AKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHK---DGKEVKA------S 7933

Query: 910  TSITVGNTTMHVMKDL-LPETT------YRIRIQAINEIGAGPFSQFIKAKTRPLPPLPP 962
              +T+ N   H+   L +P++       Y I ++  N++G+   S  I  K   LP    
Sbjct: 7934 DRLTMKND--HISAHLEVPKSVRADAGIYTITLE--NKLGSATAS--INVKVIGLPGPCK 7987

Query: 963  RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR-FISIYRGPSH-TYKVQRL 1020
             ++ +     S KL W +          + Y L+  +  +R +I +  G +  ++ V+ L
Sbjct: 7988 DIKASDITKSSCKLTW-EPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDL 8046

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCE---ILWETV 1077
                 Y FR++A ++ G G + E       +        P   ++   + E   I W+  
Sbjct: 8047 IPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP 8106

Query: 1078 PSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
                G  +  YI++ +   E  +K+  +      T+   GL+   +Y+FRV A
Sbjct: 8107 LYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRA 8159



 Score =  142 bits (359), Expect = 1e-33
 Identities = 212/900 (23%), Positives = 347/900 (38%), Gaps = 98/900 (10%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +++ + +   +LSW PP+        G S   +Y V   +  R    ++  +     C++
Sbjct: 12899 KINKMYSDRAMLSWEPPL------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSV 12952

Query: 343   KDLRPATDYHVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
             + L    +Y  R+ A   Y       +EP         P    PP +++ +K  +T+ WK
Sbjct: 12953 EKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWK 13012

Query: 401   APIDN-GSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              P D+ GS IT YLLE        W +  R           ++  K T L     Y FR+
Sbjct: 13013 PPADDGGSPITGYLLEKRETQAVNWTKVNRKPII-------ERTLKATGLQEGTEYEFRV 13065

Query: 452   AARNDIG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
              A N  G    S  S+          P  P+ P++     + V+L W KP       +I 
Sbjct: 13066 TAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIG 13125

Query: 509   YTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
             Y +E++  ++DN        ++L  T   V  L   TQY+FR+ A N  G S PS+V   
Sbjct: 13126 YLVEVKRADSDNWVRCNLP-QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDK 13184

Query: 566   TTSPDRPGPPTRPL---------VKGPVTSHGF-SVKWDPPKDNGGSEILKYLLEITDGN 615
                 D   PP   L         ++  VT   +  VK  PP             +IT   
Sbjct: 13185 HYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP------------KITWSK 13232

Query: 616   SEAN-QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQC 674
                N +  +     +T++  T L+   + K  A        + C +      + +     
Sbjct: 13233 PNVNLRDRIGLDIKSTDFD-TFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13291

Query: 675   RPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---- 729
              P  V  +   K+  ++ W+ P  + G  +  Y V   +  D   + +     EC+    
Sbjct: 13292 PPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV---QKRDAERKSWSTVTTECSKTSF 13348

Query: 730   -VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE 788
              V NL  G  Y FRV A N+ G G   +  +   A+  PG      +         +GW+
Sbjct: 13349 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWK 13408

Query: 789   SPDSSGAD-ISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
              P S G   I  Y +++  +E   + +      ++  +DL    +Y  R+ A N+ G G 
Sbjct: 13409 KPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGT 13468

Query: 848   YSEL-VLCQTPASAPD----PVSTLCVLEEE--------PLDAYPDSPSACLVLNWEEPC 894
              SE+ V+ +    APD     +  LC L +E        P+   P +PS    ++W++  
Sbjct: 13469 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP-APS----VSWKK-- 13521

Query: 895   NNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
               G + LA    +   S  V NTT+ ++ D       +  I   N  G    +  IK   
Sbjct: 13522 --GEDPLATDTRVSVESSAV-NTTL-IVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVG 13577

Query: 955   RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLED--RNKRFISIYRGPS 1012
             +P  P  P ++      +++ LKW         +E   Y L+  D   NK          
Sbjct: 13578 KPGIPTGP-IKFDEVTAEAMTLKWAPPKD-DGGSEITNYILEKRDSVNNKWVTCASAVQK 13635

Query: 1013  HTYKVQRLTEFTCYSFRIQAASE--AGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC 1070
              T++V RL E   Y+FR+ A ++   GEG  SE         VP     P +  +  +S 
Sbjct: 13636 TTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSV 13695

Query: 1071  EILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              + W       G P+  Y L+        +K+  K       F+++GL    +Y FRV A
Sbjct: 13696 SLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMA 13755



 Score =  142 bits (358), Expect = 2e-33
 Identities = 226/946 (23%), Positives = 363/946 (38%), Gaps = 128/946 (13%)

Query: 260   SDLQEYELEVKRVQDILSG------IEKPQV-------SNIQARAVVLSWAPPVGLSCGP 306
             SD  +Y + +K V     G      + KP +         + A A+ L WAPP       
Sbjct: 13551 SDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPP------K 13604

Query: 307   HSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYA--MYNSVKG 364
               G S   +Y +   D   +       + ++    +  L    +Y  RV A   Y   +G
Sbjct: 13605 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEG 13664

Query: 365   SCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNS 423
               SEP+        P+ P PP +      S++L W  P   G S IT Y LE+ E  RNS
Sbjct: 13665 LKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE--RNS 13722

Query: 424   GFRQCFFGS---QKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
                +    +    +  K+T L   + Y FR+ A N  G    S         +    P  
Sbjct: 13723 LLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGK 13782

Query: 481   PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTG-EDLTCTVKNLK 539
             P ++      VTL W++P+     ++  Y +E ++  + +     +    +   TV +L 
Sbjct: 13783 PEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLV 13842

Query: 540   RSTQYKFRLTASNTEGK-SCPSE---VLVCTTSPDRPGPPTRPLVKGPVTS--------H 587
                +Y+FR+ A NT G  S PSE    ++C    + P     P +K  +T         +
Sbjct: 13843 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLN 13902

Query: 588   GFSVKWDP-PKDN---GGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP-G 640
               S+   P PK +    G +I    +        ++   + Y+    A EYT T   P G
Sbjct: 13903 AISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 13962

Query: 641   TLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESG 700
             T                  E + V  L + PG   P  +      K   L W  P  + G
Sbjct: 13963 TKV----------------EHVKVTVLDV-PGPPGPVEISNVSAEKAT-LTWTPPLEDGG 14004

Query: 701   CEVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGP--YSD 756
               +  Y +E  E   +   V       C      L+ G  Y FRV A+N  G G    S+
Sbjct: 14005 SPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSE 14064

Query: 757   VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIY 815
               ++    GPPG  + P +S        V W+ P D  G++I+ Y +E  E ++SL  + 
Sbjct: 14065 PVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE-KKSLRWVR 14123

Query: 816   H----GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VLCQTPASAPDPVSTLC 868
                   +D R ++  L   + Y  R+ A N+AG GP SE    VL +  A  P P S   
Sbjct: 14124 AIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPH 14183

Query: 869   VLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID---------LGDTSITVGNTT 918
             V          D+      L W +P  + G EI  Y ++         + DT+ T    T
Sbjct: 14184 VT---------DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14234

Query: 919   MHVMKDLLPETTYRIRIQAINEIGAG-----PFSQFIKAKTRPLPPLPPRLECAAAGPQS 973
               V+ DL  +  Y  RI AIN+ G G     P  + ++ +      + P  E  A   ++
Sbjct: 14235 QFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVERE------MAPDFELDAELRRT 14288

Query: 974   LKLKWGDS-----NSKTHAAEDIVYT---LQLEDRNKRFISIYRGPSHTYK-VQRLTEFT 1024
             L ++ G S       K   A ++ +T   + L++R     +I    S T   +     + 
Sbjct: 14289 LVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNR----ANIENTESFTLLIIPECNRYD 14344

Query: 1025  CYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP 1084
                F +   + AG+      +        P  +   R T +  +S  + W+ +P + G  
Sbjct: 14345 TGKFVMTIENPAGK---KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWD-LPLIDGGS 14400

Query: 1085  --VNYILQVLVGRESEYK-QVYKGEEATFQISGLQTNTDYRFRVCA 1127
                NYI++        Y     K  + T++++GL    +Y FRV A
Sbjct: 14401 RITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMA 14446



 Score =  142 bits (358), Expect = 2e-33
 Identities = 222/931 (23%), Positives = 360/931 (38%), Gaps = 93/931 (9%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S      +  ++  +V LSW PP+        G +   +Y V   +  R     
Sbjct: 18697 RVLDSPSAPVNLTIREVKKDSVTLSWEPPL------IDGGAKITNYIVEKRETTRKAYAT 18750

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPP-- 385
             I  +  +    +++L+    Y+ RV A       +    +EPV  +      E P PP  
Sbjct: 18751 ITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVS------EPPLPPGR 18804

Query: 386   -KLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
               L   ++++ T++W+ P  D GSKIT Y++E  + K +  +  C         ++ L  
Sbjct: 18805 VTLVDVTRNTATIKWEKPESDGGSKITGYVVEM-QTKGSEKWSTCTQVKTLEATISGLTA 18863

Query: 444   AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA--PRLVRAGITWVTLQWSKPEGC 501
                Y FR+AA N+ G S   Q  V     +I   PS   P           L+   P   
Sbjct: 18864 GEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKG 18923

Query: 502   SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK-SCPS 560
              P+  + +  + Q  +     +   +    + ++K   +     + L  SN+ G  + P 
Sbjct: 18924 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 18983

Query: 561   EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQ 620
              ++V     DRPGPP  P+    V+    ++ W+PP+ +GG +I  Y++E  +  S    
Sbjct: 18984 TIIVL----DRPGPPG-PIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTS--TT 19036

Query: 621   WEVAYSGSA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
             W +     A T      L  G+ Y+ R C  +  G S  SES  V    +A     PP  
Sbjct: 19037 WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV----VAEYPFSPPGP 19092

Query: 680   LGRPK-----HKEVHLEWDVPASESGCEVSEYSVEMTEPEDV----ASEVYHGPELECTV 730
              G PK        + + W VP ++ G  V  Y +E  E   +    A+++    + +  V
Sbjct: 19093 PGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIA-DTQMKV 19151

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGW 787
               L  G +Y +RV A N  G G  S   E   A     PPGQ   P ++      V + W
Sbjct: 19152 SGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQ---PEVTNITRKSVSLKW 19208

Query: 788   ESPD-SSGADISEYRLEWGE--DEESLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQA 843
               P    GA I+ Y +E  E  D   L+  Y    +T FE+ +L    +Y  R+ A N A
Sbjct: 19209 SKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAA 19268

Query: 844   GAGPYSELVLCQTPASAPDPV------------STLCVLEEEPLDAYPDSPSACL-VLNW 890
              +   SE      P    D V              + V   E L    D     L V++W
Sbjct: 19269 DS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19326

Query: 891   EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
                  +G EI           I+  N T+  +KD +   T +  +   N  G    +   
Sbjct: 19327 ---AKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNC 19380

Query: 951   KAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
             K   +P PP  P LE      +   L WG       A  D  Y ++  + +    +I  G
Sbjct: 19381 KVLDKPGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADID-YYIVEKRETSHLAWTICEG 19438

Query: 1011  PSH--TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK--SVPPTIKAPRVTQLE 1066
                  + KV +L +   Y FR+   ++ G G   E+         +VP    +  +T + 
Sbjct: 19439 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19498

Query: 1067  GNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKGEEATFQI--SGLQTNTDYRF 1123
               S  + W    S  G  ++ YI++        + +V K      ++  +GL+   +Y +
Sbjct: 19499 KESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEY 19558

Query: 1124  RVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             RV A        +  +G   PS    L R+E
Sbjct: 19559 RVYA--------ENAAGLSLPSETSPLIRAE 19581



 Score =  141 bits (355), Expect = 4e-33
 Identities = 217/905 (23%), Positives = 352/905 (38%), Gaps = 95/905 (10%)

Query: 292   VVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
             +V+SW PP+        G S   +Y +   + G+D    +  +  +  C +  L    DY
Sbjct: 10432 MVISWKPPLD------DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDY 10485

Query: 352   HVRVYA--MYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKI 409
               R++A  +Y       S+ +        P+ P  P +   +K S  + W  P D G  I
Sbjct: 10486 IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPI 10545

Query: 410   TNYLLEWDE--GKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG---TSGYSQ 464
             TNY+LE  E   KR +   +         ++  L     Y FR++A N+IG    S  S+
Sbjct: 10546 TNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSK 10605

Query: 465   EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
              V        P  P  P  +      V L W  P      +++ Y +E Q+  ++     
Sbjct: 10606 PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRA 10665

Query: 525   KYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP------ 575
              +T E    T   V  L+    YKFR+ A N  G+S P+ V       DR  PP      
Sbjct: 10666 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDA 10725

Query: 576   ----TRPLVKGPVTSHGFSVKWDP-PKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
                  + +  G        +K  P PK       + +  E  D  ++A + +V   GS  
Sbjct: 10726 NMAREQHIKVGDTLRLSAIIKGVPFPK-------VTWKKEDRDAPTKA-RIDVTPVGSKL 10777

Query: 631   EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI-APGQCRPPRVL--GRPKHKE 687
             E      + G +Y L      T  +   S+++ V+ L +  PG   PPR L     +   
Sbjct: 10778 EIRNAAHEDGGIYSL------TVENPAGSKTVSVKVLVLDKPG---PPRDLEVSEIRKDS 10828

Query: 688   VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH-----GPELECTVGNLLPGTVYRFR 742
              +L W  P  + G  ++ Y VE     DVAS  +        +      +L  G  Y FR
Sbjct: 10829 CYLTWKEPLDDGGSVITNYVVER---RDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFR 10885

Query: 743   VRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             V A N  G GP+ +  +   A     PPG  K           V + W  PD   G+ I+
Sbjct: 10886 VAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT 10945

Query: 799   EYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAG-PYSEL-VLC 854
              Y +E+ ++E + + I   T T  E  +  L     Y  R++A N  G G P + + + C
Sbjct: 10946 GYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIEC 11004

Query: 855   QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP----CNNGSEILA---YTIDL 907
             Q     P     + ++E   + A        ++     P      +GSEI     YT++ 
Sbjct: 11005 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVET 11064

Query: 908   GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECA 967
              + S      ++  +K+ L   T   +I   N  G+   +  +     P PP  P +   
Sbjct: 11065 DNFS------SVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP-INIL 11117

Query: 968   AAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLED-RNKRFISIYRGPSHT-YKVQRLTEFT 1024
                P+ + + W     K      ++ Y ++ +D R   +  +  G S T  K+  L +  
Sbjct: 11118 DVTPEHMTISW--QPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGC 11175

Query: 1025  CYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKG 1082
              Y FR++A ++ G G P   T T +  K  PP+    P VT +  N+  + W    S  G
Sbjct: 11176 EYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGG 11235

Query: 1083  DPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
              P+            ++ +V K    +  F+++GL     Y FRV A        + L+G
Sbjct: 11236 SPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFA--------ENLAG 11287

Query: 1141  AFSPS 1145
                PS
Sbjct: 11288 LSKPS 11292



 Score =  140 bits (353), Expect = 7e-33
 Identities = 167/655 (25%), Positives = 264/655 (40%), Gaps = 55/655 (8%)

Query: 281  KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
            KP V ++   +V L+W  P       H G +   SY + +   G D   ++       + 
Sbjct: 7492 KPTVKDVGKTSVRLNWTKP------EHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQH 7545

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTL 397
             L  L    +Y  RV A+  + +   SEP            P PP+   + + +K++  L
Sbjct: 7546 LLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADL 7605

Query: 398  QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
            +W  P  D GS ITNY++E  + +R              C +T L     Y FR+AA N 
Sbjct: 7606 KWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENA 7665

Query: 457  IGTSGYSQ---EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
            IG S Y++    V+       P  P A  +V      V L+W  P+      +  Y +E 
Sbjct: 7666 IGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEK 7725

Query: 514  QEDENDNLFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
            +E          K  G D    V ++   T+ +F++ A N  G   PSE     +  D  
Sbjct: 7726 KERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPT 7785

Query: 573  GPPTRPLVKGPVTSHG---FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             PP+ PL    VT  G    ++ W PP+ NGGS I+ Y +E+    +E  +W    S   
Sbjct: 7786 SPPSPPLDLH-VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTE--KWMRVNSRPI 7842

Query: 630  TEYTF---THLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK 686
             +  F     + P   Y LR   ++  G S+ SE +    ++  P  C+P   +    H 
Sbjct: 7843 KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSE-ISENVVAKDP-DCKP--TIDLETHD 7898

Query: 687  EVHLEWD---VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR--- 740
             + +E +   +P       V   S      E  AS+         +    +P +V     
Sbjct: 7899 IIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAG 7958

Query: 741  -FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADIS 798
             + +   N  G    S   ++    GP    KA  I  T   C L  WE P+   G  I 
Sbjct: 7959 IYTITLENKLGSATASINVKVIGLPGPCKDIKASDI--TKSSCKLT-WEPPEFDGGTPIL 8015

Query: 799  EYRLEWGEDEESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQAGAGPYSEL---VL 853
             Y LE  E      +     + +  + ++DL+P  +Y  R++A N+ G G Y EL   V+
Sbjct: 8016 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8075

Query: 854  CQTPASAPDPVSTLCVLEEEPLDAYPDSPSA-CLVLNWEEPC-NNGSEILAYTID 906
             Q P   PDP          P+D    +P+A  + + W+ P  + GS+I+ Y I+
Sbjct: 8076 AQDPKQPPDP----------PVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIE 8120



 Score =  140 bits (352), Expect = 9e-33
 Identities = 225/902 (24%), Positives = 350/902 (38%), Gaps = 115/902 (12%)

Query: 257  SNDSDLQEYELEVKRVQDILSG------IEKPQV------SNIQARAVVLSWAPPVGLSC 304
            S  SD   Y L+++     +SG      I +P         +I   +V L+W PP     
Sbjct: 6960 SERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGG 7019

Query: 305  GPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKG 364
             P +G      Y V   +  R    K++    +LE  + DL    +Y  +V A      G
Sbjct: 7020 SPLTG------YVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPG 7073

Query: 365  S---CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGK 420
                  EPV+ +T +  P+ P   K   R+ +S+ L W  P  D GS+I  Y++E     
Sbjct: 7074 EPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVE----- 7128

Query: 421  RNSGFRQCFFGSQK-----------HCKLTKLCPAMGYTFRLAARNDIGTSGYS---QEV 466
                  +C  GS K             ++T L     Y +R+ A N  G S  S   +E+
Sbjct: 7129 ------RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEI 7182

Query: 467  VCYTLGNIPQMPSAPRLVRAGIT---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFH 523
                    P++    +L+ AG+T      ++        PE  IT+T      + D    
Sbjct: 7183 QAVDTQEAPEIFLDVKLL-AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRIT 7241

Query: 524  PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
             +   +  T T+ + KRS    + + A N  G++     +V     D+PGPP    +   
Sbjct: 7242 IENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRAT---AVVEVNVLDKPGPPAAFDITD- 7297

Query: 584  VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTL 642
            VT+    + W+PP+D+GGS+I  Y++E    +SE   W +++ +   T +  T L P   
Sbjct: 7298 VTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV--WHKLSSTVKDTNFKATKLIPNKE 7355

Query: 643  YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE--------VHLEWDV 694
            Y  R    +  G  +  ++ P+     A  Q  PP   G P   E        V L W  
Sbjct: 7356 YIFRVAAENMYGVGEPVQASPI----TAKYQFDPP---GPPTRLEPSDITKDAVTLTWCE 7408

Query: 695  PASESGCEVSEYSVEMTEPE-DVASEVYHGPELECT--VGNLLPGTVYRFRVRALNDGGY 751
            P  + G  ++ Y VE  +P+ D        P  + T  V  L     YRFRV A N  G 
Sbjct: 7409 PDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGP 7468

Query: 752  GPYSDVSE---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE- 806
            G  S  +E   I     PP     P +       V + W  P+   GA I  Y +E  + 
Sbjct: 7469 GKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKT 7528

Query: 807  -DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE---LVLCQTPASAPD 862
              +E + +      T+  +  L+   +Y  R++A N+AG    SE    VLC+     P 
Sbjct: 7529 GTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPS 7588

Query: 863  PVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTIDLGDTSITVGNTTMHV 921
            P   L V+      A          L W  P  + GS I  Y ++  D       T    
Sbjct: 7589 PPRWLEVINITKNTA---------DLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 7639

Query: 922  MKD-------LLPETTYRIRIQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAG 970
            +KD       L   + Y  R+ A N IG   +++    + AK     P PP  L      
Sbjct: 7640 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVT 7699

Query: 971  PQSLKLKWGDSNSKTHAAEDIV-YTLQLEDR-NKRFISIYR--GPSHTYKVQRLTEFTCY 1026
             + + LKW     K      I  Y ++ ++R   R++   +  GP   ++V  + E T  
Sbjct: 7700 KRHVDLKW--EPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 7757

Query: 1027 SFRIQAASEAGEGPFS---ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             F+++A +EAG G  S   E  +     S P       VT        I W+      G 
Sbjct: 7758 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 7817

Query: 1084 PV 1085
            P+
Sbjct: 7818 PI 7819



 Score =  140 bits (352), Expect = 9e-33
 Identities = 224/898 (24%), Positives = 357/898 (39%), Gaps = 91/898 (10%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             + +I    V L+W  P       H G S    Y +    KG D ++  I + + LEC ++
Sbjct: 14476 IMDITKSTVSLAWPKP------KHDGGSKITGYVIEAQRKGSD-QWTHITTVKGLECVVR 14528

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSE--PVSFTTHSCAPECPFP---PKLAHRSKSSLTLQ 398
             +L    +Y  +V A+ ++ + +  E  PV     +  PE        KL   +K+   ++
Sbjct: 14529 NLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVI-AKAGDNIK 14587

Query: 399   WKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAAR 454
              + P+    K T   + W +G    K+          +     + +   +    + L AR
Sbjct: 14588 VEIPVLGRPKPT---VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTAR 14644

Query: 455   NDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             N +G  G   +V+   + +IP  P+ P +       +VT  W  PE      +  Y +E+
Sbjct: 14645 NIVGEVG---DVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 14701

Query: 514   QEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLVCTTSPDR 571
             ++ ++        T    T     L    +Y+FR+ A N  G      S  +V       
Sbjct: 14702 RQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKV 14761

Query: 572   PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATE 631
             PGPP  P V   VT    ++ W  P  +GGS IL Y +E  + N    Q           
Sbjct: 14762 PGPPGTPQVTA-VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 14820

Query: 632   YTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIA--PGQCRPPRVLGRPKHKEV 688
             +  + L  G  Y+ R    +  G S+ S+ S P+  L     PG+   P  L   +H  V
Sbjct: 14821 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK---PVPLNITRHT-V 14876

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRA 745
              L+W  P    G +++ Y VE  +  +   + +   +  E E TV  L     Y FRV A
Sbjct: 14877 TLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIA 14936

Query: 746   LNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY---R 801
              N  G   P S+ S+  T        K        D  +L   E+     AD+S      
Sbjct: 14937 KNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLE-ADVSGRPPPT 14995

Query: 802   LEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP 861
             +EW +D + LE    GT  + EI+     A +   L   +       +  +    P    
Sbjct: 14996 MEWSKDGKELE----GT-AKLEIK----IADFSTNLVNKDSTRRDSGAYTLTATNPGGFA 15046

Query: 862   DPVSTLCVLE-----EEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTS---- 911
               +  + VL+     E PL     +   C VL+W  P ++G ++I  Y +   +TS    
Sbjct: 15047 KHIFNVKVLDRPGPPEGPLAVTEVTSEKC-VLSWFPPLDDGGAKIDHYIVQKRETSRLAW 15105

Query: 912   ----ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPPLPPRL- 964
                   V  T + V K LL    Y  R+ A+N+ G G    S+ + A     PP PP+  
Sbjct: 15106 TNVASEVQVTKLKVTK-LLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNP 15164

Query: 965   ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKRFISIYRGPSHTYK 1016
             E       S+ + WG  +S    +E I Y ++  D+        NK+ ++  R     YK
Sbjct: 15165 EVTTITKDSMVVCWGHPDSDG-GSEIINYIVERRDKAGQRWIKCNKKTLTDLR-----YK 15218

Query: 1017  VQRLTEFTCYSFRIQAASEAG---EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEIL 1073
             V  LTE   Y FRI A + AG     P S  Y    T   P     PRV     +S  I 
Sbjct: 15219 VSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIA 15278

Query: 1074  WETVPSMKGDPV-NYILQVLVGRESEYKQVY--KGEEAT-FQISGLQTNTDYRFRVCA 1127
             W       G  +  Y++++ +  E E++ V    G +AT + I+GL  N +Y+ R+ A
Sbjct: 15279 WNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15336



 Score =  139 bits (351), Expect = 1e-32
 Identities = 213/920 (23%), Positives = 344/920 (37%), Gaps = 85/920 (9%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE 317
             N    +EY + VK V D         V  I   +  ++W PP+        G S   +Y 
Sbjct: 13273 NSCGKKEYTIVVK-VLDTPGPPVNVTVKEISKDSAYVTWEPPI------IDGGSPIINYV 13325

Query: 318   VALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC 377
             V   D  R     +     +    + +L     Y  RV+A      G   E       S 
Sbjct: 13326 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13385

Query: 378   APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQK 434
              P      K+   SKSS ++ WK P  D GS+I  Y++++  +E K    +++       
Sbjct: 13386 TPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK----WQRVMKSLSL 13441

Query: 435   HCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIP----QMPSAPRLVRAGITW 490
                   L     YTFR++A N+ G  G   E+      ++      +   P L       
Sbjct: 13442 QYSAKDLTEGKEYTFRVSAENENG-EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKEN 13500

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
                +   P    P   +++         D     + +  + T  V + ++S   K+ +T 
Sbjct: 13501 SNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITL 13560

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G     E  +      +PG PT P+    VT+   ++KW PPKD+GGSEI  Y+LE
Sbjct: 13561 KNVAGTK---EGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILE 13617

Query: 611   ITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTL 667
               D  S  N+W    S    T +  T L  G  Y  R    +  G  +  +S P+  R  
Sbjct: 13618 KRD--SVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHP 13675

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPEL- 726
                P    PP ++   +H  V L W  P    G  ++ Y +E  E   +  +  +   + 
Sbjct: 13676 FDVPDAPPPPNIVD-VRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIR 13734

Query: 727   --ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDG 781
               +  V  L  G  Y FRV A+N  G G  S  SE   A     PPG  K   I+ T + 
Sbjct: 13735 MRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG--KPEVINITRNS 13792

Query: 782   CVLVGWESPDSSGADISEYRLEWGE-DEESLELIYHGT--DTRFEIRDLLPAAQYCCRLQ 838
               L+  E     G  ++ Y +E  +   +S     H    +  F + DL+   +Y  R++
Sbjct: 13793 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13852

Query: 839   AFNQAGA----GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN----W 890
             A N AGA       +E ++C+    AP       VL+    D         +VLN     
Sbjct: 13853 AKNTAGAISAPSESTETIICKDEYEAP-----TIVLDPTIKDGLTIKAGDTIVLNAISIL 13907

Query: 891   EEPCNNGSEILAYTIDLGDTSIT----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPF 946
              +P    S   A   D+  + IT       ++M  +K    +      I A N  G    
Sbjct: 13908 GKPLPKSSWSKAGK-DIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK-- 13964

Query: 947   SQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAED-----IVYTL 995
              + +K     +P  P  +E +    +   L W      G S  K++  E      +++T+
Sbjct: 13965 VEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTV 14024

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
               ED            S  +   +L +   Y FR+ A +  G+G    SE          
Sbjct: 14025 VSEDIQ----------SCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGP 14074

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG--EEATF 1110
             P   + P V+ +  N+  + W+      G  +  Y ++    +   + +  K    +   
Sbjct: 14075 PGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 14134

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             +++GLQ  + Y FRV A  R
Sbjct: 14135 KVTGLQEGSTYEFRVSAENR 14154



 Score =  136 bits (343), Expect = 1e-31
 Identities = 209/842 (24%), Positives = 320/842 (38%), Gaps = 80/842 (9%)

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWK 400
             DL     Y  RV A      G   E +  TT       P PP   K+   +K+++ L WK
Sbjct: 9477  DLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWK 9536

Query: 401   API-DNGSKITNYLLE---WDE-GKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
              P  D GS +T+Y++E   WD  G +   +RQC     +  + T   L     Y FR+ A
Sbjct: 9537  PPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKA 9596

Query: 454   RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR----------------AGITWVTLQWSK 497
              N  G S  S  V        P MP +  L                   G+ + TL W K
Sbjct: 9597  VNAAGVSKPSATVGPCDCQR-PDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFK 9655

Query: 498   PEGCSPE--EVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
                  P+  E + Y   + +   D+           TCT  +   +RS    + +TA N 
Sbjct: 9656  APPKKPDNKEPVLYDTHVNKLVVDD-----------TCTLVIPQSRRSDTGLYTITAVNN 9704

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITD 613
              G +     L       RPGPP  P+    V++   ++ W PPKD+GGS+I  Y++E  +
Sbjct: 9705  LGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKRE 9761

Query: 614   GNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIA 670
              N +   W  V+       YT   L  G  Y  R    +  G  +  +S P   R L   
Sbjct: 9762  ANRKT--WVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSV 9819

Query: 671   PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT 729
             PG    P V    ++  + + W+ P  + G  V+ Y +EM +        V   P    T
Sbjct: 9820  PGAPDKPTVSSVTRN-SMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMT 9878

Query: 730   VG------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP--PGQCKAPCISCTPDG 781
             +G       L+ G+ Y+FRV A+N  G GP S  S+  TA  P  P     P ++     
Sbjct: 9879  LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKS 9938

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGTD-----TRFEIRDLLPAAQYCC 835
                + W  P    G+ ++ Y +E+   EE  E    G D     T+  +  L   A Y  
Sbjct: 9939  SADLEWSPPLKDGGSKVTGYIVEY--KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKF 9996

Query: 836   RLQAFNQAGAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP 893
             R++A N AG G   E+  + +       P   L     + +  +       +  ++ + P
Sbjct: 9997  RVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPP 10056

Query: 894   CNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
                   +   T+    T  T   ++  V+K+          + A NE G    +  +   
Sbjct: 10057 PTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10116

Query: 954   TRPLPPLPPRLECAAAGPQSLKLKW-GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPS 1012
               P P   P L       +S KL W    +       + V   +  DR       Y    
Sbjct: 10117 DVPGPVGTPFLAHNLTN-ESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTR 10175

Query: 1013  HTYKVQRLTEFTCYSFRIQAASEAGEGPF---SETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
                 VQ L +   Y FRI A +  G GPF   SE        +VP   +   V ++  N+
Sbjct: 10176 QNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNT 10235

Query: 1070  CEILWETVPSMKG--DPVNYILQV-LVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRV 1125
               + W   P   G  + +NY+L+  L+G E  +K          + + GL+    Y +RV
Sbjct: 10236 VTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10294

Query: 1126  CA 1127
              A
Sbjct: 10295 SA 10296



 Score =  136 bits (343), Expect = 1e-31
 Identities = 208/839 (24%), Positives = 321/839 (38%), Gaps = 83/839 (9%)

Query: 342   LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---LAHRSKSSLTLQ 398
             + DL     Y+ RV A+     G   EP        A E P PP+   +   SKSS  L 
Sbjct: 22012 VNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLA 22068

Query: 399   WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
             W  P  D GS+IT YLLE  + K +  + +     Q    + +L     Y FR+ A+ND 
Sbjct: 22069 WLKPDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND- 22126

Query: 458   GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCS------PEEVITY 509
               +GYS+    ++   I +    P     GIT   +T +   P          P   +T+
Sbjct: 22127 --AGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTW 22184

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
              LE    +  +      T +  T TVK+  R    ++ LT  NT G    S  +V     
Sbjct: 22185 KLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI--- 22241

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-S 628
              RPGP T P+    V++    + W  PKD GG+EI  Y++E  +  + A  W++  S   
Sbjct: 22242 GRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTA--WQLVNSSVK 22299

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV 688
              T+   THL     Y  R    +  G S+  ES P+    IA     PP    RP+   V
Sbjct: 22300 RTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPI----IAEHPFVPPSAPTRPEVYHV 22355

Query: 689   -----HLEWDVPASESGCEVSEYSVEMTEPEDVA-SEVYHGPELECT--VGNLLPGTVYR 740
                   + W+ P  + G ++  Y VE  E   +   +    P LEC   V  L+ G  Y+
Sbjct: 22356 SANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQ 22415

Query: 741   FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISE 799
             FR  ALN  G    S+ S    A  P      P ++      V + W +P    G+ +  
Sbjct: 22416 FRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVG 22475

Query: 800   YRLEWGE-----DEESLELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAG--------A 845
             Y +E        D   L+  Y   +D  F +  L     Y  R+ A N AG         
Sbjct: 22476 YIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST 22535

Query: 846   GPYSELVLCQTPASAP---------DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN 896
             GP    V C+   + P           + T+    +  LDA         ++ W +   +
Sbjct: 22536 GP----VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKII-WTK--GD 22588

Query: 897   GSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
                 L   + L  T    G     V+K      + +  +   N  G    S  +K    P
Sbjct: 22589 KELDLCEKVSLQYT----GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 22644

Query: 957   LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG--PSHT 1014
              P    +L  +    +   L W     +   AE   Y ++  + ++    I  G  P+ +
Sbjct: 22645 GP--CGKLTVSRVTQEKCTLAW-SLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLS 22701

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEG--PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             Y V RL +   Y FR++A ++ G G    SE      + ++P     P           I
Sbjct: 22702 YVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIII 22761

Query: 1073  LWETVPSMKGDPV-NYILQVLVGRESEYKQV---YKGEEATFQISGLQTNTDYRFRVCA 1127
              W    S  G+ + NY++     +   + +V   Y   +   +++ L    DY+FRV A
Sbjct: 22762 QWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTA 22820



 Score =  136 bits (342), Expect = 1e-31
 Identities = 223/927 (24%), Positives = 346/927 (37%), Gaps = 101/927 (10%)

Query: 258   NDSDLQEYELEVKRVQDILSGIEKP-QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSY 316
             N S   + E++VK VQD    +  P + +NI    + L W  P+   C P +       Y
Sbjct: 21538 NASGSAKAEIKVK-VQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT------HY 21590

Query: 317   EVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTT 374
              +   +  R     I    E        L    +Y  RV A+     G    S+PV    
Sbjct: 21591 IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQI 21650

Query: 375   HSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFG-- 431
                 P+ P  P+ ++ + +S+TL W  P  D GS+I  Y+LE  E K     +       
Sbjct: 21651 QYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPI 21710

Query: 432   SQKHCKLTKLCPAMGYTFRLAARNDIGT---SGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
             S+   K+T L     Y F + A N  G    SG S+ + C    N P  P+  ++     
Sbjct: 21711 SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSK 21770

Query: 489   TWVTLQWSKPEGCSPEEVITYTLEI-QEDENDNLFHPKYTGE---DLTCTVKNLKRSTQY 544
             T V+L+WSKP      E+I Y +E+ + D  D  +H K   E       TV +L+   +Y
Sbjct: 21771 TTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD--WH-KVNAEACVKTRYTVTDLQAGEEY 21827

Query: 545   KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVK-------- 592
             KFR++A N  GK    EV     + DR   P   +      +H    G S++        
Sbjct: 21828 KFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGR 21887

Query: 593   ------WDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
                   W  P  N     L+  +  TD  S     E      A +YT T           
Sbjct: 21888 PTPTAVWSKPDSNLS---LRADIHTTDSFSTLTV-ENCNRNDAGKYTLT----------- 21932

Query: 647   ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEY 706
                 +  G    + ++ V      PG    P            L WD P  + G  +  Y
Sbjct: 21933 --VENNSGSKSITFTVKVLDTPGPPG----PITFKDVTRGSATLMWDAPLLDGGARIHHY 21986

Query: 707   SVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGPYSDVSEIT 761
              VE  E    + +V      +CT     V +L  G  Y FRV A+N+ G G   ++ E  
Sbjct: 21987 VVEKREASRRSWQVI---SEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPI 22043

Query: 762   TAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL-IYHGTD 819
              A   P   +   +  T     ++ W  PD   G+ I+ Y LE  +      +   H   
Sbjct: 22044 VATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ 22103

Query: 820   TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE------LVLCQTPASAPDPVSTLCVLEEE 873
               F +  L+   +Y  R++A N AG   YSE       V+ + P    +P + L  +  +
Sbjct: 22104 LTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEPQI--EPTADLTGITNQ 22158

Query: 874   PLDAYPDSPSACLVLNWEEPCNNGS----EILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
              +     SP    V     P    +    E+     D    + T   TT+ V KD +   
Sbjct: 22159 LITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV-KDSMRGD 22217

Query: 930   TYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
             + R  +   N  G   FS  +    RP P   P +E ++   +S  L WG+         
Sbjct: 22218 SGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGEPKDGGGTEI 22276

Query: 990   DIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTF 1047
                   + E     +  +      T  KV  LT++  YSFR+ + +  G   P       
Sbjct: 22277 TNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPII 22336

Query: 1048  STTKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGE 1106
             +    VPP+    P V  +  N+  I WE       D  + I+   V ++     ++  E
Sbjct: 22337 AEHPFVPPSAPTRPEVYHVSANAMSIRWE---EPYHDGGSKIIGYWVEKKERNTILWVKE 22393

Query: 1107  ------EATFQISGLQTNTDYRFRVCA 1127
                   E  ++++GL    +Y+FR  A
Sbjct: 22394 NKVPCLECNYKVTGLVEGLEYQFRTYA 22420



 Score =  135 bits (341), Expect = 2e-31
 Identities = 234/959 (24%), Positives = 370/959 (38%), Gaps = 149/959 (15%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
             +KP VS++   ++ ++W  P      P +G         +   K R  +  I      + 
Sbjct: 9824  DKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK-RVNRDPIKAMTLGVS 9882

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT--HSCAPECPFPPKLAHRSKSSLTL 397
               +  L   +DY  RVYA+  +  G  S P    T     AP  P  PK+   +KSS  L
Sbjct: 9883  YKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADL 9942

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLC-----PAMGYTFRL 451
             +W  P+ D GSK+T Y++E+ E     G  +   G  K  + TKL          Y FR+
Sbjct: 9943  EWSPPLKDGGSKVTGYIVEYKE----EGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRV 9998

Query: 452   AARN--DIGTSGYSQEVVCYTLGNIP---QMPSAPR---LVRAG-----ITWV------T 492
              A N   IG  G   +V+      +    Q+ ++ R   +V AG     I +V      T
Sbjct: 9999  RAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPT 10058

Query: 493   LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN 552
             + W+  E   P+E    T  I                  +  +KN +RS Q  + L A N
Sbjct: 10059 VTWNMNERTLPQEATIETTAISS----------------SMVIKNCQRSHQGVYSLLAKN 10102

Query: 553   TEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT 612
               G+    +  +     D PGP   P +   +T+    + W  P+D+GGS I  Y++E  
Sbjct: 10103 EAGER---KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKR 10159

Query: 613   DGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLS 668
             +  S+   W  V Y+ +    T   L  G  Y  R      I  G   + SE+L +R   
Sbjct: 10160 E--SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPI 10217

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP---- 724
               P +     V    K+  V L W+ P  + G E+  Y   + E   + +E +H      
Sbjct: 10218 TVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINY---VLESRLIGTEKFHKVTNDN 10273

Query: 725   --ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT---- 778
                 + TV  L  G  Y +RV A+N  G G  S  ++       P  CK      T    
Sbjct: 10274 LLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTK-------PITCKDELAPPTLHLD 10326

Query: 779   -PDGCVLVGWESPDSSG--ADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCC 835
               D   +   E+   +G  +   + ++ W +DE  +       D R  I+   PA     
Sbjct: 10327 FRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVL-----EDDRTHIK-TTPATLALE 10380

Query: 836   RLQAFNQAGAGPYSELV---------LCQT-----PASAPDPVSTLCVLEEEPLDAYPDS 881
             +++A  ++ +G Y  +V          CQ      P     PVS            + + 
Sbjct: 10381 KIKA-KRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVS------------FDEV 10427

Query: 882   PSACLVLNWEEPCNN-GSEILAYTIDLGDTSITV--------GNTTMHVMKDLLPETTYR 932
                 +V++W+ P ++ GS+I  Y I+  +    V          TT  V K LL    Y 
Sbjct: 10428 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSK-LLEGKDYI 10486

Query: 933   IRIQAINEIGAGP--FSQFIKAKTR-PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAE 989
              RI A N  G      S  +KAK R  +P  P +         S  + W    +K H   
Sbjct: 10487 FRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTW----NKPHDGG 10542

Query: 990   DIVYTLQLEDR---NKRFISIYRGPSHTY---KVQRLTEFTCYSFRIQAASEAGEG---P 1040
               +    LE R   +KR+  + + P H Y   +V  L E   Y FR+ A +E G G   P
Sbjct: 10543 KPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSP 10602

Query: 1041  FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              S+        + P     P       NS ++ W+      G  +  YI++     + E+
Sbjct: 10603 PSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEW 10662

Query: 1100  KQVYKGEEA----TFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSE 1154
             ++     E+     ++++GL+    Y+FRV A    ++ + E   A  P    V  R E
Sbjct: 10663 RRANHTPESCPETKYKVTGLRDGQTYKFRVLA----VNAAGESDPAHVPEPVLVKDRLE 10717



 Score =  135 bits (340), Expect = 2e-31
 Identities = 228/931 (24%), Positives = 358/931 (38%), Gaps = 118/931 (12%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC 340
             K  V ++   +V LSW  P       H G S    Y V +  K  + K+      + L+ 
Sbjct: 16639 KITVDDVTRNSVSLSWTKP------EHDGGSKIIQYIVEMQAKHSE-KWSECARVKSLQA 16691

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL-----AHRSKSSL 395
              + +L    +Y  RV A+  + KG  S+P S      A +    P +     ++  +   
Sbjct: 16692 VITNLTQGEEYLFRVVAV--NEKGR-SDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQ 16748

Query: 396   TLQWKAPIDNGSKITNYLLEWDEG----KRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRL 451
              L+ + PI    K T   + W +     K+ +              + +     G  + +
Sbjct: 16749 DLKIEVPISGRPKPT---ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805

Query: 452   AARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYT 510
                N +G    S E+V  TL   P  P  P +        +TL W+ P      ++  Y 
Sbjct: 16806 TVANVVGQKTASIEIV--TLDK-PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYI 16862

Query: 511   LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS--CPSEVLVCTTS 568
             ++ ++           T    T  V  LK  T+Y+FR+ A N  G+S    S+ +V    
Sbjct: 16863 VQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 16922

Query: 569   PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS----EANQWEVA 624
                PGPP  P     ++     ++W  P +NGGS ++ Y LE  + NS    + N+  + 
Sbjct: 16923 YKEPGPPGTPFATA-ISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII- 16980

Query: 625   YSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
                  T++   +L+ G  Y+ R      +  G  S+ SE    R     PG   P  V  
Sbjct: 16981 ---HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMV-- 17035

Query: 682   RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTV 738
               K  E+ L+W  P  + G  ++ Y VE  +  D   + +   +  E + TV  L     
Sbjct: 17036 --KRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQR 17093

Query: 739   YRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWES----PD 791
             Y FRV A N  G    S  S+ T       + + P IS  P   D  V+   E+     D
Sbjct: 17094 YEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEAD 17151

Query: 792   SSGADISEYRLEW----GEDEESLELIYHGTDTR--FEIRDLL--PAAQYCCRLQAFNQA 843
               G  +    +EW     E EES       TD +    ++D +     QY   L+A N A
Sbjct: 17152 VHGKPLPT--IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI--LRASNVA 17207

Query: 844   GAGPYSELV-LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEIL 901
             G+  +   V +   P     PV    V  E+              L W  P  +G S+I 
Sbjct: 17208 GSKSFPVNVKVLDRPGPPEGPVQVTGVTSEK------------CSLTWSPPLQDGGSDIS 17255

Query: 902   AYTIDLGDTS-----ITVGNTTMHVMK--DLLPETTYRIRIQAINEIGAG-PFSQFIKAK 953
              Y ++  +TS     +       + +K   LL    Y  RI A+N+ G G P        
Sbjct: 17256 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 17315

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR--------NKR 1003
               P  LP  P  LE       S+ + W   +S    +E I Y ++  DR        NKR
Sbjct: 17316 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDG-GSEIIGYIVEKRDRSGIRWIKCNKR 17374

Query: 1004  FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSV----PPTIK 1058
              I+  R      +V  LTE   Y FR+ A + AG G P   T  +     V    PPT  
Sbjct: 17375 RITDLR-----LRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPT-- 17427

Query: 1059  APRVTQLEGNSCEILW-ETVPSMKGDPVNYILQVLVGRESEYKQV--YKGEEAT-FQISG 1114
                +     NS  + W + +     + + Y++++    E E++ V    G   T F+IS 
Sbjct: 17428 NAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK 17487

Query: 1115  LQTNTDYRFRVCACRRC-LDTSQELSGAFSP 1144
             L  + +Y+ RVCA  +  L  +  + G   P
Sbjct: 17488 LTEHQEYKIRVCALNKVGLGEATSVPGTVKP 17518



 Score =  135 bits (340), Expect = 2e-31
 Identities = 181/709 (25%), Positives = 289/709 (40%), Gaps = 74/709 (10%)

Query: 466   VVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP 524
             +   TLG  P  P  P R        V L W  PE     E+  Y++E +E    N    
Sbjct: 21152 ITVITLGP-PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMV 21210

Query: 525   KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP--SEVLVCTTSPDRPGPPTRPLVKG 582
               +    T  V NL +  +Y+FR+ A N  G S P  S ++V       PGPP +P++  
Sbjct: 21211 CSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21270

Query: 583   PVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTL 642
              VTS G S+ WD P  +GGSE+  + +E  + NS   Q       S  EY  T L  G  
Sbjct: 21271 -VTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLD 21329

Query: 643   YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPAS 697
             Y+ R    ++ G S  S+     TL+++P    PP   G P + +V      L+W+ P  
Sbjct: 21330 YQFRVYAENSAGLSSPSDPSKF-TLAVSPVD--PP---GTPDYIDVTRETITLKWNPPLR 21383

Query: 698   ESGCEVSEYSVEMTEPED--VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
             + G ++  YS+E  +  +  V        E + TV  L PG  Y FR+ A N    G  S
Sbjct: 21384 DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARN--AVGTIS 21441

Query: 756   DVSEITTAAGPPGQCKAPCISCTP---DGCVLVGWESPDSS----GADISEYRLEWGEDE 808
               S+ +       +   P +   P   DG ++   ES        G  +   R+ W +D 
Sbjct: 21442 PPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP--RVTWFKDG 21499

Query: 809   ESLE--LIYHGTD----TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ-TPASAP 861
               +E  +    TD    T   +RD     +    ++A N +G+      V  Q TP    
Sbjct: 21500 VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21559

Query: 862   DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVG----- 915
              P+    +  E+            + L W+ P N+G + I  Y I+  +TS         
Sbjct: 21560 GPIRFTNITGEK------------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIED 21607

Query: 916   --NTTMHVMKDLLPETTYRIRIQAINEIGAG-PF-SQFIKAKTR-PLPPLPPRLECAAAG 970
                   +    L+    Y+ R+ A+N+ G G P  S  + A+ +  +P  P   E +   
Sbjct: 21608 KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNIT 21667

Query: 971   PQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY--RGPSHT-YKVQRLTEFTCYS 1027
               S+ L W    S   +        + E ++ R++ +   R  S T +KV  LTE   Y 
Sbjct: 21668 GNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYE 21727

Query: 1028  FRIQAASEAGEGPFSETYTFSTTKSV-----PPTIKAPRVTQLEGNSCEILWETVPSMKG 1082
             F + A + AG GP S        +       PPT+   +VT     +  + W + P   G
Sbjct: 21728 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTV--VKVTDTSKTTVSLEW-SKPVFDG 21784

Query: 1083  --DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCA 1127
               + + YI+++      ++ +V      +  + ++ LQ   +Y+FRV A
Sbjct: 21785 GMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 21833



 Score =  133 bits (335), Expect = 9e-31
 Identities = 209/942 (22%), Positives = 351/942 (37%), Gaps = 109/942 (11%)

Query: 243   GIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGL 302
             G++ T R +  +       L+   +  +   D+      P + +++  +V L+W  P   
Sbjct: 13646 GMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKT 13705

Query: 303   SCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362
                P +G    +    +L  K R  K  I       +  +  L    +Y  RV A+  + 
Sbjct: 13706 GGSPITGYHLEFKERNSLLWK-RANKTPI----RMRDFKVTGLTEGLEYEFRVMAINLAG 13760

Query: 363   KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKR 421
              G  S P          + P  P++ + +++S+TL W  P  D G K+T Y++E  +   
Sbjct: 13761 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPS 13820

Query: 422   NSGFR-------QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT----SGYSQEVVCYT 470
              S  +       +C F       +T L     Y FR+ A+N  G     S  ++ ++C  
Sbjct: 13821 KSWMKANHVNVPECAF------TVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKD 13874

Query: 471   LGNIPQMPSAPRL-----VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPK 525
                 P +   P +     ++AG T V    S      P+   +++   ++    ++    
Sbjct: 13875 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKS--SWSKAGKDIRPSDITQIT 13932

Query: 526   YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
              T      T+K   R    ++ +TA+N  G        V  T  D PGPP  P+    V+
Sbjct: 13933 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH---VKVTVLDVPGPPG-PVEISNVS 13988

Query: 586   SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYK 644
             +   ++ W PP ++GGS I  Y+LE  +  +    W V      +  +  T L  G  Y 
Sbjct: 13989 AEKATLTWTPPLEDGGSPIKSYILEKRE--TSRLLWTVVSEDIQSCRHVATKLIQGNEYI 14046

Query: 645   LRACCISTGGHSQCSESLPVRTLSI--APGQCRPPRVLGRPKHKEVHLEWDVPASESGCE 702
              R   ++  G  +  +S PV+ +     PG    P V    K+    + W  P  + G E
Sbjct: 14047 FRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTAT-VSWKRPVDDGGSE 14105

Query: 703   VSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             ++ Y VE  E +    V +      +L C V  L  G+ Y FRV A N  G GP S+ S+
Sbjct: 14106 ITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASD 14165

Query: 760   ---ITTAAGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLE--------WGED 807
                +  AA PPG    P ++ T      + W  P    G +I+ Y +E        W +D
Sbjct: 14166 SVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKD 14225

Query: 808   EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTL 867
                  L      T+F + DL    +Y  R+ A N AG G          PA  PD    +
Sbjct: 14226 TTGTAL----RITQFVVPDLQTKEKYNFRISAINDAGVG---------EPAVIPD----V 14268

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS--ITVGNTTMHVMKDL 925
              ++E E    +         L        G  I  +    G  +  +T     +++    
Sbjct: 14269 EIVEREMAPDFELDAELRRTL----VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRA 14324

Query: 926   LPETTYRIRIQAINEIG--------------AGPFSQFIKAKTRPLPPLPPRLECAAAGP 971
               E T    +  I E                AG  S F+  +    P     L       
Sbjct: 14325 NIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITK 14384

Query: 972   QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH--TYKVQRLTEFTCYSFR 1029
              S+ L W D       +    Y ++  +  ++  S      H  TYKV  L+E   Y FR
Sbjct: 14385 DSVTLHW-DLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 14443

Query: 1030  IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYI 1088
             + A +E G G  +ET         P    +  +  +  ++  + W       G  +  Y+
Sbjct: 14444 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 14503

Query: 1089  LQ-------------VLVGRESEYKQVYKGEEATFQISGLQT 1117
             ++              + G E   + + +GEE TFQ+  + +
Sbjct: 14504 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNS 14545



 Score =  130 bits (327), Expect = 8e-30
 Identities = 183/802 (22%), Positives = 305/802 (38%), Gaps = 105/802 (13%)

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             ++   TL W  P  D G++IT+Y++E  E  R +              +T+L     Y F
Sbjct: 22656 TQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIF 22715

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
             R+ A N  G      S+ +V      IP  P  P  V  G   + +QW+KPE     E+ 
Sbjct: 22716 RVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEIS 22775

Query: 508   TYTLEIQEDENDNL--FHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV--- 562
              Y ++ +E ++      +  Y   D    V +L     Y+FR+TA N  G S PSE    
Sbjct: 22776 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNF 22835

Query: 563   LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
             + C      PGPP+ P V    T H  S+ W  P  +GG++I+ Y+LE+ +   + +QW 
Sbjct: 22836 ISCREPSYTPGPPSAPRVVD-TTKHSISLAWTKPMYDGGTDIVGYVLEMQE--KDTDQWY 22892

Query: 623   VAYSGSA---TEYTFTHLKPGTLYKLRACCISTGGHSQCSESL----PVRTLSIAPGQCR 675
               ++ +    TE+T   LK G  Y  R   ++  G S+ SES+    PV  + I      
Sbjct: 22893 RVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEI------ 22946

Query: 676   PPRVLGRPKHKEVHLEWDVP----ASESG-----CEVSEYSVEMTEPEDVASEVYHGPEL 726
             P   L     K V +          S SG        S+  +++     + +   +   +
Sbjct: 22947 PDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI 23006

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V     G   ++ + A N  G       + +      PG C +  +       V + 
Sbjct: 23007 VDKVNRYDAG---KYTIEAENQSGK---KSATVLVKVYDTPGPCPSVKVKEVSRDSVTIT 23060

Query: 787   WESPD-SSGADISEYRLEWGEDEESLELIYHGTD----TRFEIRDLLPAAQYCCRLQAFN 841
             WE P    GA ++ Y +E  + E ++      T     T + I  L+    Y  R+   N
Sbjct: 23061 WEIPTIDGGAPVNNYIVE--KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPEN 23118

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEI 900
               G G   E       +  P   + L V+         D   + + L WE+P  + GS +
Sbjct: 23119 IYGIGEPCETSDAVLVSEVPLVPAKLEVV---------DVTKSTVTLAWEKPLYDGGSRL 23169

Query: 901   LAYTIDLGDTS-------ITVGNTTM-HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA 952
               Y ++            +T+  T + H +  L     Y  RI+A NE G     + + A
Sbjct: 23170 TGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTA 23229

Query: 953   KT----RPLPPL----------------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV 992
              T    R LP +                P  L    AG       W  + SK   +E + 
Sbjct: 23230 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 23289

Query: 993   YTL--QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
                  ++     R  +I     +T +++ +T  T  + ++    + G             
Sbjct: 23290 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG------------- 23336

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQVYKG-EEA 1108
                PPT    ++ +++  S  I WE      G P++ Y+++        +  V +    +
Sbjct: 23337 ---PPTGPI-KIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS 23392

Query: 1109  TFQISGLQTNTDYRFRVCACRR 1130
             TF+ + L    +Y FRV A  R
Sbjct: 23393 TFKFTRLTEGNEYVFRVAATNR 23414



 Score =  130 bits (326), Expect = 1e-29
 Identities = 226/960 (23%), Positives = 367/960 (38%), Gaps = 129/960 (13%)

Query: 281   KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKG-RDGKYKIIYSGEELE 339
             KP V++I   A  +SW  P      P +G    Y     ++ K  R  K  I     +L+
Sbjct: 11212 KPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREVTGKWVRVNKTPIA----DLK 11264

Query: 340   CNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLT 396
               +  L     Y  RV+A      S     S+P+        P  P  PKL  +S+ +  
Sbjct: 11265 FRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD 11324

Query: 397   LQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGY 447
             L W  P+ D GS I  Y++E        W+   ++   RQC F      ++  L     Y
Sbjct: 11325 LVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAF------RVPGLIEGNEY 11378

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---------VRAGITWVTLQWSKP 498
              FR+ A N +G  G  +E+    +      P    L         VR G T   L   K 
Sbjct: 11379 RFRIKAANIVG-EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKG 11437

Query: 499   EGCSPEEVITYTLE----IQEDENDNLFHPKYTGEDLT---CTVKNLKRSTQYKFRLTAS 551
                 PE  IT+T E    ++E   D +       +DL      +K   R+   K+ ++A 
Sbjct: 11438 R---PEPDITWTKEGKVLVREKRVDLI-------QDLPRVELQIKEAVRADHGKYIISAK 11487

Query: 552   NTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEI 611
             N+ G +  S ++      DRPGP     V   VT    ++ W+ P DNGGSEI  +++E 
Sbjct: 11488 NSSGHAQGSAIVNVL---DRPGPCQNLKVTN-VTKENCTISWENPLDNGGSEITNFIVEY 11543

Query: 612   TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES-LPVRTLSIA 670
                N +   W +  S         +L     Y  R C  +  G     E+  P+  ++  
Sbjct: 11544 RKPNQKG--WSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPI 11601

Query: 671   PGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHG--PEL 726
                  P  +    K K  V+L+W  P  + G     Y VE   +  D    V+ G   E 
Sbjct: 11602 DRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11661

Query: 727   ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
                V   +   +Y FRV+  N+GG   +    E+          + P +     G + V 
Sbjct: 11662 HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKE----DLQKPVLDLKLSGVLTVK 11717

Query: 787   WESPDSSGADISEY---RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                     A +       + W +D+++ +L       R +I     ++++   L    ++
Sbjct: 11718 AGDTIRLEAGVRGKPFPEVAWTKDKDATDLT---RSPRVKIDTRADSSKF--SLTKAKRS 11772

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEE-------EPLDAYPDSPSACLVLNWEEPCNN 896
               G Y  +V     A +    +T+ VL++       + +D   D  + C    W+ P ++
Sbjct: 11773 DGGKY--VVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVC----WDPPEDD 11826

Query: 897   GS-EILAYTIDLGDTSITVGNTTMHVMKDLLPETT---------YRIRIQAINEIGAGP- 945
             G  EI  Y ++  +T   V +T    +  L P TT         Y  R++A N+IG GP 
Sbjct: 11827 GGCEIQNYILEKCETKRMVWSTYSATV--LTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 11884

Query: 946   -FSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
               S+ + AKT   +P  P PP  E      + + + W         +    +  + E  +
Sbjct: 11885 TESKPVIAKTKYDKPGRPDPP--EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 11942

Query: 1002  KRFISIYRG--PSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV-----P 1054
              R++ + +   P    KVQ L     Y FR++A +E G G  S        K       P
Sbjct: 11943 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGP 12002

Query: 1055  PTIKAPRVTQLEGNSCEILWETVPSMKGDP-VNYILQVL-----VGRESEYKQVYKGEEA 1108
             PT    RV     +S  + W       G P + Y++++         +  +K+     + 
Sbjct: 12003 PT--NFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12060

Query: 1109  T---FQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSL 1164
                 F ++ L  N +Y FRVCA  +  +    EL  A  P    +L+  E+ L   M  L
Sbjct: 12061 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASMRKL 12118



 Score =  129 bits (325), Expect = 1e-29
 Identities = 204/922 (22%), Positives = 356/922 (38%), Gaps = 76/922 (8%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D  S     +V+ I   +V ++W PP+        G S   +Y V   +  R     
Sbjct: 16532 RVLDTPSPPVNLKVTEITKDSVSITWEPPL------LDGGSKIKNYIVEKREATRKSYAA 16585

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR 390
             ++ +  +    +  L+    Y+ RV A      G  ++       +  P+ P    +   
Sbjct: 16586 VVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDV 16645

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +++S++L W  P  D GSKI  Y++E  + K +  + +C         +T L     Y F
Sbjct: 16646 TRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLF 16704

Query: 450   RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVI 507
             R+ A N+ G S      V     ++   P       +    V   L+   P    P+  I
Sbjct: 16705 RVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI 16764

Query: 508   TYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             T+T +    +     +   + +  T ++K   +    ++ +T +N  G+   S  +V   
Sbjct: 16765 TWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL- 16823

Query: 568   SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG 627
               D+P PP  P+    V++   ++ W+PP   GG +I  Y+++  D  +    W+V  + 
Sbjct: 16824 --DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD--TTTTVWDVVSAT 16879

Query: 628   SA-TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP--- 683
              A T    T LK GT Y+ R    +  G S   ES P+    +A    + P   G P   
Sbjct: 16880 VARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI----VAQYPYKEPGPPGTPFAT 16935

Query: 684   --KHKEVHLEWDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPG 736
                   + ++W  P +  G  V  Y +E  E        V   + H  + +    NL  G
Sbjct: 16936 AISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ--NLEEG 16993

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
               Y FRV A N  G G  S  SE   A  P      P         + + W  P    G+
Sbjct: 16994 IEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGS 17053

Query: 796   DISEYRLEWGE--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELV 852
              I+ Y +E  +  D   ++  +    +T+F +  L    +Y  R+ A N AGA       
Sbjct: 17054 MITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGA------- 17106

Query: 853   LCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE----EPCNNGSEILAYTIDLG 908
                 P+ +  P++    +E   +   P      +V   E    E   +G  +       G
Sbjct: 17107 -ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 17165

Query: 909   DTSI------TVGNT---TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
             D  I       + NT    + ++KD +     +  ++A N  G+  F   +K   RP PP
Sbjct: 17166 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17225

Query: 960   LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV-YTLQLEDRNKRFISIYRGP--SHTYK 1016
               P ++      +   L W  S        DI  Y ++  + ++   ++      +++ K
Sbjct: 17226 EGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLK 17282

Query: 1017  VQRLTEFTCYSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
             V +L E   Y FRI A ++ G G   E+          +P   K+  VT +  +S  + W
Sbjct: 17283 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 17342

Query: 1075  ETVPSMKG-DPVNYILQVLVGRESEYKQVYKGE--EATFQISGLQTNTDYRFRVCACRRC 1131
                 S  G + + YI++        + +  K    +   +++GL  + +Y FRV A    
Sbjct: 17343 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA---- 17398

Query: 1132  LDTSQELSGAFSPSAAFVLQRS 1153
                 +  +G   PS A V  ++
Sbjct: 17399 ----ENAAGVGEPSPATVYYKA 17416



 Score =  129 bits (323), Expect = 2e-29
 Identities = 206/920 (22%), Positives = 363/920 (39%), Gaps = 81/920 (8%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EELEC 340
             P+V+ I   ++ + W+ P+       SG      Y +   DK   G +K++     +   
Sbjct: 20575 PEVTKITKNSMTVVWSRPIADGGSDISG------YFLEKRDKKSLGWFKVLKETIRDTRQ 20628

Query: 341   NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSLTL 397
              +  L   +DY  RV A+  + +G  SEP  F   +   + P PP   ++A  +KSS+TL
Sbjct: 20629 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITL 20688

Query: 398   QWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAAR 454
              W  P+ D GS +T Y++E  +G+          G  +  +  ++ L P + Y FR++A 
Sbjct: 20689 GWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAV 20748

Query: 455   NDIGTSG---YSQEVVCYTLGNIPQMPSAPRLVRAGITWV--TLQWSKPEGCSPEEVITY 509
             N  G       ++ V    +   P++     L  + I      +Q   P    P   +T+
Sbjct: 20749 NCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTW 20808

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
               + +   +D  +  + T      T+  + R+   K+ LT  N  G+  P    V     
Sbjct: 20809 RKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE--PKSSTVSVKVL 20866

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV-AYSGS 628
             D P    +  VK  V+    ++ WDPP  +GGS I+ Y++E  D       W V ++  S
Sbjct: 20867 DTPAACQKLQVKH-VSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRT--WSVVSHKCS 20923

Query: 629   ATEYTFTHLKPGTLYKLRACCISTGGHSQ-CSESLPVRTLSIAPGQCRPPRVLGRPKHKE 687
             +T +    L   T +  R    +  G  + C  + PV+   + P   R   +    K   
Sbjct: 20924 STSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEV-PAPIRDLSMKDSTK-TS 20981

Query: 688   VHLEWDVPASESGCEVSEYSVEMT-EPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V L W  P  + G  ++EY VE   + E   S        E  V  L   +V  FRV A 
Sbjct: 20982 VILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAK 21041

Query: 747   NDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGE 806
             N+ G      +  IT         K   I+   D   + G +     G ++       G+
Sbjct: 21042 NEKGLSDPVTIGPITV--------KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGK 21093

Query: 807   DEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPV 864
              + S+  +  G   +    +R      +    ++   +   G Y+ ++L         P+
Sbjct: 21094 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT-VILDNAVCRIAVPI 21152

Query: 865   STLCV----LEEEPLDAYPDSPSACLVLNWEEPCNNGS-EILAYTIDLGDTSIT------ 913
             + + +      + P+  + +  +  ++L+W+ P +NG  EI  Y+I+  +TS T      
Sbjct: 21153 TVITLGPPSKPKGPI-RFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVC 21211

Query: 914   --VGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTR---PLPPLPPRLEC 966
               V  TT  V  +L+ +  Y+ R++A N  G      S  I AK +   P PP  P +  
Sbjct: 21212 SSVARTTFKV-PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21270

Query: 967   AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEF 1023
               +    + L W D+      +E   + ++ ++RN    + ++        Y+   L E 
Sbjct: 21271 VTS--DGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 21327

Query: 1024  TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
               Y FR+ A + AG    S+   F+   S       P    +   +  + W   P   G 
Sbjct: 21328 LDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP-PLRDGG 21386

Query: 1084  P--VNYILQVLVGRESEYKQVYKG-EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
                V Y ++   G E   +  +    E  + ++GL     Y FR+ A        +   G
Sbjct: 21387 SKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA--------RNAVG 21438

Query: 1141  AFSPSAAFVLQRSEVMLTGD 1160
               SP +    Q S +++T D
Sbjct: 21439 TISPPS----QSSGIIMTRD 21454



 Score =  128 bits (322), Expect = 3e-29
 Identities = 231/931 (24%), Positives = 352/931 (37%), Gaps = 155/931 (16%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+ SNI   ++ L+WA P         G S    Y +   +K      K+I      E  
Sbjct: 21661 PEPSNITGNSITLTWARPES------DGGSEIQQYILERREKKSTRWVKVISKRPISETR 21714

Query: 342   LK--DLRPATDYHVRVYAMYNSVKG---------SCSEPVSFTTHSCAPECPFPPKLAHR 390
              K   L    +Y   V A   +  G          C EPV+       P  P   K+   
Sbjct: 21715 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVN------PPGPPTVVKVTDT 21768

Query: 391   SKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQK-HCKLTKLCPAMGYT 448
             SK++++L+W  P+ D G +I  Y++E  +       +       K    +T L     Y 
Sbjct: 21769 SKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYK 21828

Query: 449   FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-----------VRAGIT-------- 489
             FR++A N  G  G S EV   T+  + ++ +AP L           VRAG +        
Sbjct: 21829 FRVSAINGAG-KGDSCEVTG-TIKAVDRL-TAPELDIDANFKQTHVVRAGASIRLFIAYQ 21885

Query: 490   ---WVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKF 546
                  T  WSKP+           L ++ D +        T    T TV+N  R+   K+
Sbjct: 21886 GRPTPTAVWSKPDS---------NLSLRADIHT-------TDSFSTLTVENCNRNDAGKY 21929

Query: 547   RLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
              LT  N  G KS    V V     D PGPP  P+    VT    ++ WD P  +GG+ I 
Sbjct: 21930 TLTVENNSGSKSITFTVKVL----DTPGPP-GPITFKDVTRGSATLMWDAPLLDGGARIH 21984

Query: 606   KYLLEITDGNSEANQWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLP 663
              Y++E  + +  +  W+V  S   T   F    L  G  Y  R   ++  G     E   
Sbjct: 21985 HYVVEKREASRRS--WQV-ISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYG---VGEPYE 22038

Query: 664   VRTLSIAPGQCRPPR---VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASE 719
             +    +A  Q  PPR   V+   K   V L W  P  + G  ++ Y +EM +   D   E
Sbjct: 22039 MPEPIVATEQPAPPRRLDVVDTSKSSAV-LAWLKPDHDGGSRITGYLLEMRQKGSDFWVE 22097

Query: 720   VYHGPELECTVGNLLPGTVYRFRVRALNDGGYG-----------------PYSDVSEITT 762
               H  +L  TV  L+  T Y FRV+A ND GY                  P +D++ IT 
Sbjct: 22098 AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN 22157

Query: 763   -----AAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHG 817
                   AG P     P IS  P     V W+        + E RL   ++ + + +    
Sbjct: 22158 QLITCKAGSPFTIDVP-ISGRP--APKVTWK--------LEEMRL---KETDRVSITTTK 22203

Query: 818   TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDA 877
               T   ++D +        L   N AG   +S  V+       P PV+        P++ 
Sbjct: 22204 DRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV---IGRPGPVT-------GPIEV 22253

Query: 878   YPDSPSACLVLNWEEPCN-NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETT------ 930
                S  +C VL+W EP +  G+EI  Y ++  ++  T        +K    + T      
Sbjct: 22254 SSVSAESC-VLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYM 22312

Query: 931   -YRIRIQAINEIGAG-PFSQFIKAKTRPL--PPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              Y  R+ + N  G   P          P   P  P R E       ++ ++W +      
Sbjct: 22313 EYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRW-EEPYHDG 22371

Query: 987   AAEDIVYTLQLEDRNK-RFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              ++ I Y ++ ++RN   ++   + P     YKV  L E   Y FR  A + AG    SE
Sbjct: 22372 GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASE 22431

Query: 1044  TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDP--VNYILQ----VLVGRES 1097
                    ++       P VT +  ++  ++W + P+  G    V YI++      VG   
Sbjct: 22432 ASRPIMAQNPVDAPGRPEVTDVTRSTVSLIW-SAPAYDGGSKVVGYIIERKPVSEVGDGR 22490

Query: 1098  EYKQVYK-GEEATFQISGLQTNTDYRFRVCA 1127
               K  Y    +  F ++ L     Y FRV A
Sbjct: 22491 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLA 22521



 Score =  128 bits (321), Expect = 4e-29
 Identities = 204/914 (22%), Positives = 339/914 (37%), Gaps = 102/914 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             +V D  +  +K QV ++    V L W PP+        G S   +Y +   D  +     
Sbjct: 20864 KVLDTPAACQKLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWSV 20917

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK---L 387
             + +        L DL   T +  RV A  N +     EP   T    A E P P +   +
Sbjct: 20918 VSHKCSSTSFKLIDLSEKTPFFFRVLAE-NEI--GIGEPCETTEPVKAAEVPAPIRDLSM 20974

Query: 388   AHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
                +K+S+ L W  P  D GS IT Y++E  +GK    +           ++++L     
Sbjct: 20975 KDSTKTSVILSWTKPDFDGGSVITEYVVE-RKGKGEQTWSHAGISKTCEIEVSQLKEQSV 21033

Query: 447   YTFRLAARNDIGTSG-------YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPE 499
               FR+ A+N+ G S          +E++     ++  +P A   VR G     +    P 
Sbjct: 21034 LEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHN---VHLELPY 21090

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
                P+  I++  +    +         T   +T ++KN K+    K+ +   N     C 
Sbjct: 21091 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV---CR 21147

Query: 560   SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
               V +   +   P  P  P+    + +    + WD P+DNGG EI  Y +E  +  S+ N
Sbjct: 21148 IAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE-TSQTN 21206

Query: 620   QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRV 679
                V  S + T +   +L     Y+ R    +  G SQ      V ++ +A  Q R P  
Sbjct: 21207 WKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL----VSSIIVAKHQFRIPGP 21262

Query: 680   LGRPKHKEV-----HLEWDVPASESGCEVSEYSVEMTEP-----EDVASEVYHGPELECT 729
              G+P    V      L WD P  + G EV+ + VE  E      + V +    G E   T
Sbjct: 21263 PGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRAT 21322

Query: 730   VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES 789
                L+ G  Y+FRV A N  G    SD S+ T A  P      P         + + W  
Sbjct: 21323 --GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNP 21380

Query: 790   P-DSSGADISEYRLEWGEDEESLEL--IYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAG 846
             P    G+ I  Y +E  +  E          ++ ++ +  L P  +Y  R+ A N  G  
Sbjct: 21381 PLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT- 21439

Query: 847   PYSELVLCQTPASAPDPVSTLCVLEEE---PLDAYPDSPSACLVLNWEEPC--------- 894
                         S P   S + +  +E   P+  +       L++   E           
Sbjct: 21440 -----------ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGR 21488

Query: 895   --------NNGSEI-----LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEI 941
                      +G EI     +  T  LG TS+ V        +D   +      ++A N  
Sbjct: 21489 PVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFV--------RDATRDHRGVYTVEAKNAS 21540

Query: 942   GAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
             G+      +K +  P   + P       G +     W D+      A    Y ++  + +
Sbjct: 21541 GSAKAEIKVKVQDTPGKVVGPIRFTNITGEK--MTLWWDAPLNDGCAPITHYIIEKRETS 21598

Query: 1002  KRFISIY--RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PF-SETYTFSTTKSVPPTI 1057
             +   ++   +  + +Y   +L     Y FR+ A ++ G G P  S+        +VP   
Sbjct: 21599 RLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAP 21658

Query: 1058  KAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKG---EEATFQIS 1113
               P  + + GNS  + W    S  G  +  YIL+    + + + +V       E  F+++
Sbjct: 21659 GIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVT 21718

Query: 1114  GLQTNTDYRFRVCA 1127
             GL    +Y F V A
Sbjct: 21719 GLTEGNEYEFHVMA 21732



 Score =  126 bits (317), Expect = 1e-28
 Identities = 220/925 (23%), Positives = 347/925 (37%), Gaps = 120/925 (12%)

Query: 283  QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
            + S+I   +  L+W PP         G +    Y +   + GR     ++    +L   +
Sbjct: 7990 KASDITKSSCKLTWEPP------EFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTV 8043

Query: 343  KDLRPATDYHVRVYAMYNSVKGS----CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
            KDL P  +Y  RV A+ N V G        PV        P+ P   ++ + +  ++T+ 
Sbjct: 8044 KDLIPNGEYFFRVKAV-NKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTIT 8102

Query: 399  WKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG------YTFRL 451
            WK P+ D GSKI  Y++E    K    +++C     +H        A G      Y FR+
Sbjct: 8103 WKPPLYDGGSKIMGYIIE-KIAKGEERWKRC----NEHLVPILTYTAKGLEEGKEYQFRV 8157

Query: 452  AARNDIGTSGYSQ--------------EVVCYTLGNIPQMPS-APRLVRAGITWVTLQWS 496
             A N  G S  S+              +V+  T   + +    A     +G  + T+ W 
Sbjct: 8158 RAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWI 8217

Query: 497  KPEG-CSPEEVITYTL--------EIQEDE------NDNLFHPKYTGEDLTCTVKNLKRS 541
            K E    PEE+             E+QE+E         L        +    V++  R 
Sbjct: 8218 KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRP 8277

Query: 542  TQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG 600
                + +   N  G    P  V V     D PGPP    V   +       KW+PP D+G
Sbjct: 8278 DHGLYMIKVENDHGIAKAPCTVSVL----DTPGPPIN-FVFEDIRKTSVLCKWEPPLDDG 8332

Query: 601  GSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
            GSEI+ Y LE  D     ++W V  S     +Y+ T L  G  Y  R    +  G     
Sbjct: 8333 GSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPC 8392

Query: 660  ESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYSVEMTEPE 714
             S P+    +A     PP    +P  ++V      ++W+ P  ++G  +  Y +E  E  
Sbjct: 8393 VSKPL----VAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEP-KDNGSPILGYWLEKREVN 8447

Query: 715  DVA-SEVYHG--PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPG 768
                S V       L+  V  LL G  Y FRV A N  G G +S  S+  TA     PPG
Sbjct: 8448 STHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPG 8507

Query: 769  QCKAPCISCTPDGCVLVGWESPD-SSGADISEYRL--------EWGEDEESLELIYHGTD 819
                P ++ T    + + WE P  + G +I  Y +        EW    E +  +     
Sbjct: 8508 P-PIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKV----- 8561

Query: 820  TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPASAPDPVSTLCVLEEEPLDA 877
             ++ ++++   A Y  R+ A N AG GP  E   V    P   P     + V     + A
Sbjct: 8562 RQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMA 8621

Query: 878  YPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTY 931
                    +V     P         +T + G+          VG  +  ++KD L +   
Sbjct: 8622 GKTLRIPAVVTGRPVPTK------VWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHG 8675

Query: 932  RIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
            R  I A N  G+   +  ++    P P L   L+      +   L W D       +E  
Sbjct: 8676 RYVITATNSCGSKFAAARVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPED-DGGSEIT 8732

Query: 992  VYTLQLEDRNKRFISIYRGPSHTYK----VQRLTEFTCYSFRIQAASEAGEGPFSETYTF 1047
             + ++ +D     +  +R P  T +    +  L E   Y FR+ A ++ G GP  E    
Sbjct: 8733 GFIIERKDAK---MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPI 8789

Query: 1048 STTKSVPPTIKAPRVTQLEGNSCEIL--WETVPSMKGDPV-NYILQVLVGRESEYKQVYK 1104
                 + P     R+T  E     I   W+   S  G P+  YI++     + ++++V K
Sbjct: 8790 LAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNK 8849

Query: 1105 G--EEATFQISGLQTNTDYRFRVCA 1127
                  +F +  L  +  Y FRV A
Sbjct: 8850 RLCPTTSFLVENLDEHQMYEFRVKA 8874



 Score =  126 bits (316), Expect = 1e-28
 Identities = 195/799 (24%), Positives = 300/799 (37%), Gaps = 105/799 (13%)

Query: 391   SKSSLTLQWKAPIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
             +K  + + WK P+D+ GSKITNY++E  E  ++         ++  CK++KL     Y F
Sbjct: 10428 TKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIF 10487

Query: 450   RLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKP-EGCSPEEV 506
             R+ A N  G S    S  +       +P  P  P +         + W+KP +G  P  +
Sbjct: 10488 RIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP--I 10545

Query: 507   ITYTLEIQEDEN-------DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG---K 556
               Y LE +E  +        +  HP YT       V +L    QY+FR++A N  G    
Sbjct: 10546 TNYILEKRETMSKRWARVTKDPIHP-YT----KFRVPDLLEGCQYEFRVSAENEIGIGDP 10600

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
             S PS+ +       +P PP  P      T +   + W PP+ +GGS+IL Y++E      
Sbjct: 10601 SPPSKPVFAKDPIAKPSPPVNPEAI-DTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10659

Query: 617   EANQWEVA----YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPG 672
             E  +W  A     S   T+Y  T L+ G  YK R   ++  G    S+   V    +   
Sbjct: 10660 E--EWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKD 10714

Query: 673   QCRPPRV-----LGRPKHKEVHLEWDVPASESGC---EVSEYSVEMTEPEDVASEVYH-G 723
             +  PP +     + R +H +V     + A   G    +V+    +   P     +V   G
Sbjct: 10715 RLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVG 10774

Query: 724   PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCV 783
              +LE        G +Y   V   N  G    S    +    GPP   +   I    D C 
Sbjct: 10775 SKLEIRNAAHEDGGIYSLTVE--NPAGSKTVSVKVLVLDKPGPPRDLEVSEI--RKDSCY 10830

Query: 784   LVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFE--IRDLLPAAQYCCRLQAFN 841
             L   E  D  G+ I+ Y +E  +   +       T  +     + L    QY  R+ A N
Sbjct: 10831 LTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAEN 10890

Query: 842   QAGAGPYSELVLCQTPASAPDPVSTLCVLEE--EPLDA-YPDSPSACLVLNWEEP-CNNG 897
             Q G GP+ E          P P+  L  L     P D  + D     + L W +P  + G
Sbjct: 10891 QYGRGPFVE---------TPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGG 10941

Query: 898   SEILAYTIDLGDTSI-------TVGNTTMHVMKDLLPETTYRIRIQAINEIGAG-PFSQF 949
             S I  Y ++  +          TV N    V+  L    TYR R++A N +G G P +  
Sbjct: 10942 SPITGYLVEYQEEGTQDWIKFKTVTNLEC-VVTGLQQGKTYRFRVKAENIVGLGLPDTTI 11000

Query: 950   -IKAKTRPLPP-----------------LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
              I+ + + +PP                    R      G      KW    S+    E  
Sbjct: 11001 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEH- 11059

Query: 992   VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTK 1051
              YT++ ++            S    ++         ++I  ++ AG           T  
Sbjct: 11060 -YTVETDNF-----------SSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVL 11104

Query: 1052  SVPPTIKAP-RVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
              VP     P  +  +      I W+      G PV NYI++    R+  +  V  G   T
Sbjct: 11105 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11164

Query: 1110  -FQISGLQTNTDYRFRVCA 1127
               +I  LQ   +Y FRV A
Sbjct: 11165 KLKIPHLQKGCEYVFRVRA 11183



 Score =  125 bits (315), Expect = 2e-28
 Identities = 151/597 (25%), Positives = 233/597 (39%), Gaps = 48/597 (8%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +VS I+  +  L+W  P+        G S   +Y V   D        +  + ++     
Sbjct: 10820 EVSEIRKDSCYLTWKEPLD------DGGSVITNYVVERRDVASAQWSPLSATSKKKSHFA 10873

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR---SKSSLTLQW 399
             K L     Y  RV A     +G   E             P PPK  H     K+ ++L W
Sbjct: 10874 KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVW 10933

Query: 400   KAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
               P  D GS IT YL+E+ E +    + +    +   C +T L     Y FR+ A N +G
Sbjct: 10934 NKPDRDGGSPITGYLVEYQE-EGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVG 10992

Query: 459   TS--GYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQWSKPEGCSPEEVITYTLEIQ 514
                   +  + C      P +    +L+   +     T+++       P     +T +  
Sbjct: 10993 LGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGS 11052

Query: 515   EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGP 574
             E + D  +  +        T+KN  R    ++++T SN  G      V V  T  D PGP
Sbjct: 11053 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKT---VAVHLTVLDVPGP 11109

Query: 575   PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA-TEYT 633
             PT P+    VT    ++ W PPKD+GGS ++ Y++E  D  +  + W V  SGS+ T+  
Sbjct: 11110 PTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQD--TRKDTWGVVSSGSSKTKLK 11167

Query: 634   FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV----- 688
               HL+ G  Y  R    +  G     +S P    ++A  +  PP   G+P   ++     
Sbjct: 11168 IPHLQKGCEYVFRVRAENKIGVGPPLDSTP----TVAKHKFSPPSPPGKPVVTDITENAA 11223

Query: 689   HLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP--ELECTVGNLLPGTVYRFRVRAL 746
              + W +P S+ G  ++ Y +E  E       V   P  +L+  V  L  G  Y FRV A 
Sbjct: 11224 TVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 11283

Query: 747   NDGGY---GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRL 802
             N  G     P SD  +      PPG    P +         + W  P    G+ I  Y +
Sbjct: 11284 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVV 11343

Query: 803   E--------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL 851
             E        W    +  ELI       F +  L+   +Y  R++A N  G G   EL
Sbjct: 11344 ECQKPGTAQWNRINKD-ELI---RQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 11396



 Score =  125 bits (313), Expect = 3e-28
 Identities = 187/810 (23%), Positives = 304/810 (37%), Gaps = 46/810 (5%)

Query: 351   YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAP-IDNGSKI 409
             + VR    Y       SEP+        P  P  P+     K  + +QW  P  D G++I
Sbjct: 22715 FRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEI 22774

Query: 410   TNYLLEWDEGK--RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQE-- 465
             +NYL++  E K  R +   + +       K+T L     Y FR+ A N  G S  S+   
Sbjct: 22775 SNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASN 22834

Query: 466   -VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLF-- 522
              + C      P  PSAPR+V      ++L W+KP      +++ Y LE+QE + D  +  
Sbjct: 22835 FISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRV 22894

Query: 523   HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPL--- 579
             H   T  +   TV +LK   +Y FR+ A N +G S  SE +      +R   P   L   
Sbjct: 22895 HTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADD 22954

Query: 580   VKGPVTSH-GFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
             +K  VT   G S++           ++ +  +  D  S A         +   Y+   + 
Sbjct: 22955 LKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA------IIDTTESYSLLIVD 23008

Query: 639   PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
                 Y      I     S    +  +  +   PG C P   +       V + W++P  +
Sbjct: 23009 KVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPC-PSVKVKEVSRDSVTITWEIPTID 23067

Query: 699   SGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPGTVYRFRVRALNDGGYGP 753
              G  V+ Y VE  E    A   +     +C+     +  L+ GT+Y FRV   N  G G 
Sbjct: 23068 GGAPVNNYIVEKRE---AAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE 23124

Query: 754   YSDVSE-ITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEW---GEDE 808
               + S+ +  +  P    K   +  T    V + WE P    G+ ++ Y LE    G + 
Sbjct: 23125 PCETSDAVLVSEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGTER 23183

Query: 809   ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPD-PVSTL 867
                 +    T     +  L    QY  R++A N+ G     E V   T       P   L
Sbjct: 23184 WMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDL 23243

Query: 868   CVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLP 927
               + ++ +      P   ++     P    S   A +       +TV  T   V K  + 
Sbjct: 23244 STMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTV-ETHTKVAKLTIR 23302

Query: 928   ETTYRIRIQAINEIG--AGPFSQFIKA--KTRPLPPLPPRLECAAAGPQSLKLKWGDSNS 983
             ETT R   +   E+    G  S+ IK     +P PP  P ++       S+ + W     
Sbjct: 23303 ETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEIDATSITISWEPPEL 23361

Query: 984   KTHAAEDIVYTLQLEDRNKRFISIYRGPSH-TYKVQRLTEFTCYSFRIQAASEAGEGPF- 1041
                A        Q +     ++ +    +  T+K  RLTE   Y FR+ A +  G G + 
Sbjct: 23362 DGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYL 23421

Query: 1042  -SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEY 1099
              SE     ++  +P   +  ++  +  +   + W       G  V  YI++    R   +
Sbjct: 23422 QSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23481

Query: 1100  KQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
              +V K       ++ +GL    +Y  RV A
Sbjct: 23482 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTA 23511



 Score =  122 bits (307), Expect = 2e-27
 Identities = 153/606 (25%), Positives = 230/606 (37%), Gaps = 68/606 (11%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             + P PP+   +    K S  L W+ PI D G+K+ NY+++  E  R +        S+  
Sbjct: 17617 DTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTS 17676

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW 495
              K+  L     Y FR+ A N+ G     + V        P  P    L     T  +L W
Sbjct: 17677 FKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMW 17736

Query: 496   SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT--VKNLKRSTQYKFRLTASNT 553
              KPE      V+ Y +E+Q    +         E   C   V  L    +Y+FR+ A N 
Sbjct: 17737 EKPEHDGGSRVLGYVVEMQPKGTEKW---SIVAESKVCNAVVTGLSSGQEYQFRVKAYNE 17793

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSH----GFSVKWDPPKDNGGSEILKYLL 609
             +GKS P  + V   + D      +P +K P  ++    G  +K + P        + +  
Sbjct: 17794 KGKSDPRVLGVPVIAKDLT---IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISW-- 17848

Query: 610   EITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS-TGGHSQCSESLPVRTLS 668
              + DG        V    +AT  T  H+K G         ++ T      +E+L V  L 
Sbjct: 17849 -VKDGEPLKQTTRVNVEETATS-TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 17906

Query: 669   IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC 728
               PG    P          V + W+ PA   GC++S Y VE  +       +        
Sbjct: 17907 -KPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVART 17965

Query: 729   TVG--NLLPGTVYRFRVRALNDGGYGPYSDVSEITTA-----AGPPGQCKAPCISCTPDG 781
             T+    L  GT Y+FR+ A N  G     D   +         GPPG    P ++     
Sbjct: 17966 TIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPG---TPFVTSISKD 18022

Query: 782   CVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT---DTRFEIRDLLPAAQYCCRL 837
              +LV W  P +  G  I  Y LE  E    L +  + T   DT+F+   L    +Y  ++
Sbjct: 18023 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18082

Query: 838   QAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV------LNWE 891
              A N  G G              P  VS  C +  +P D  P  P A ++      L W+
Sbjct: 18083 SAENIVGIG-------------KPSKVSE-CFVARDPCDP-PGRPEAIVITRNNVTLKWK 18127

Query: 892   EPC-NNGSEILAYTIDLGD--------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
             +P  + GS+I  Y ++  D         S T    T   +  L+ +  Y  R+ A N   
Sbjct: 18128 KPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARN--A 18185

Query: 943   AGPFSQ 948
             AG FS+
Sbjct: 18186 AGNFSE 18191



 Score =  121 bits (304), Expect = 3e-27
 Identities = 199/899 (22%), Positives = 328/899 (36%), Gaps = 99/899 (11%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+ + A    L+W PP+        G +    Y +   +  R    ++    + L   +
Sbjct: 18313 KVTGVTAEKCYLAWNPPL------QDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKV 18366

Query: 343   KDLRPATDYHVRVYAM--YNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWK 400
               L P  +Y  RV A+  Y   +   S PV+       P  P  P+++  +K S+ + W 
Sbjct: 18367 TKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWA 18426

Query: 401   APIDN-GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPAMGYTFRLAARNDI 457
              P+D+ G++I  Y+LE    K    + +C   +    +L  T L     Y FR+AA N  
Sbjct: 18427 RPVDDGGTEIEGYILE-KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAA 18485

Query: 458   GTSGYSQEVVCYTLGNI---PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
             G    S+  V Y   +    P  PS P++     + V+L WSKP       V  Y +E++
Sbjct: 18486 GVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVK 18545

Query: 515   EDEND--NLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
             E   D      P    +    TV  LK +T+Y FR+ A N+EG   P+ +     + +R 
Sbjct: 18546 EAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERI 18605

Query: 573   GPPTRPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
              PP   L   ++  V                 S  L+  + I        +WE A  G  
Sbjct: 18606 EPPEIELDADLRKVVVLR-------------ASATLRLFVTIKGRPEPEVKWEKA-EGIL 18651

Query: 630   TE-------YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR 682
             T+        +FT L    + +  +   +    +          + +      P  +  R
Sbjct: 18652 TDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR 18711

Query: 683   PKHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT-----VGNLLPG 736
                K+ V L W+ P  + G +++ Y VE  E      + Y      CT     + NL  G
Sbjct: 18712 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRE---TTRKAYATITNNCTKTTFRIENLQEG 18768

Query: 737   TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS-SGA 795
               Y FRV A N+ G G  ++ +E    + PP       +         + WE P+S  G+
Sbjct: 18769 CSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGS 18828

Query: 796   DISEYRLEW-GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVL- 853
              I+ Y +E   +  E              I  L    +Y  R+ A N+ G     +L + 
Sbjct: 18829 KITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVP 18888

Query: 854   -----CQTPASAPDPVSTLCVLEEEPLD---AYPDSPSACLVLNWEEPCNNGSEILAYTI 905
                   +   S   P  T  V   E L     +   P A   +NW +      E     +
Sbjct: 18889 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQA--TVNWRKDGQTLKETTRVNV 18946

Query: 906   DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                 T       T   +K+   E      +   N  G+      I    RP PP P R++
Sbjct: 18947 SSSKT------VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRID 19000

Query: 966   CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFT 1024
               +    S+ + W                 + E  +  +  + +  + T  K+ RLT  +
Sbjct: 19001 EVSC--DSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGS 19058

Query: 1025  CYSFRIQAASEAGEGPFSET------YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
              Y FR+ A +  G+  +SE+      Y FS     P     P+V     ++  + W+   
Sbjct: 19059 EYQFRVCAENRYGKSSYSESSAVVAEYPFSP----PGPPGTPKVVHATKSTMLVTWQV-- 19112

Query: 1079  SMKGDPVNYILQVLVGRESEYKQ----------VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  PVN     ++G   EYK+               +   ++SGL     Y +RV A
Sbjct: 19113 -----PVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYA 19166



 Score =  119 bits (298), Expect = 2e-26
 Identities = 205/920 (22%), Positives = 336/920 (36%), Gaps = 106/920 (11%)

Query: 271   RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
             RV D    +   +VS++   +  +SWAPP       + G S    Y V   +  R     
Sbjct: 12197 RVLDTPGPVSDLKVSDVTKTSCHVSWAPP------ENDGGSQVTHYIVEKREADRKTWST 12250

Query: 331   IIYSGEELECNLKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKL 387
             +    ++   ++ +L P  +Y+ RV A+      V     +PV  +     P+ P   ++
Sbjct: 12251 VTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEV 12310

Query: 388   AHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKL--TKLCPA 444
                +K+S TL W  P+ D G+KI  Y+  + E ++ +  R   +   K   L  T L   
Sbjct: 12311 TEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPAD-RWTEYSVVKDLSLVVTGLKEG 12369

Query: 445   MGYTFRLAARNDIGTSGYSQEVVCYTLGN--IPQMPSAPRLVRA-------------GIT 489
               Y FR+AARN +G S   +    Y      +P     P  +               G  
Sbjct: 12370 KKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKP 12429

Query: 490   WVTLQWSKPEGCSPEEVITYT-LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRL 548
               T +W K E    +EV+T + L + + ++ ++             +K++ R     + L
Sbjct: 12430 HPTCKWKKGE----DEVVTSSHLAVHKADSSSIL-----------IIKDVTRKDSGYYSL 12474

Query: 549   TASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYL 608
             TA N+ G       +V     D PGPP  P     + +   S+ W  P ++GGS I  Y+
Sbjct: 12475 TAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYI 12531

Query: 609   LEITDGNSEANQWEVAY-SGSATEYTFTHLKPGTLYKLRACCISTGGHSQ--CSESLPVR 665
             +E  D       W  A  S + T      L PG  Y  R    +  G S+   S  +  +
Sbjct: 12532 VEKCD--VSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQ 12589

Query: 666   TLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVA-----SEV 720
                  P + +  RV  +     + + WD P S+ G  +  Y +E  E   +        +
Sbjct: 12590 FPFGVPSEPKNARVT-KVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL 12648

Query: 721   YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISC 777
                 E  C    L+ G  Y FR+ ALN  G  P S  +E  TA     PPG  K   I  
Sbjct: 12649 VRSTEYPC--AGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPG--KPEVIDV 12704

Query: 778   TPDGCVLVGWESPDSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLP 829
             T     L+        G+ I  Y +E        W     +   I       +    L  
Sbjct: 12705 TKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI---PQEEYTATGLEE 12761

Query: 830   AAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN 889
              AQY  R  A       P         P+   DPV+ L       +D      S   V  
Sbjct: 12762 KAQYQFRAIARTAVNISP---------PSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 12812

Query: 890   WEEPCNNGS------EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR--------I 935
                 C + +        +++  D G          M + ++L     + +         I
Sbjct: 12813 GTNVCLDATVFGKPMPTVSWKKD-GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTI 12871

Query: 936   QAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
              A N  G+   +  +K   +P PP   ++    +    L  +    +  +     IV   
Sbjct: 12872 TAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKR 12931

Query: 996   QLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGP--FSETYTFSTTKSV 1053
             +    N   +S    P  +  V++L E   Y FRI A ++ G G   F+E          
Sbjct: 12932 ETSRPNWAQVSA-TVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDP 12990

Query: 1054  PPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGE--EATF 1110
             P     P ++ +  +   + W+      G P+  Y+L+    +   + +V +    E T 
Sbjct: 12991 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTL 13050

Query: 1111  QISGLQTNTDYRFRVCACRR 1130
             + +GLQ  T+Y FRV A  +
Sbjct: 13051 KATGLQEGTEYEFRVTAINK 13070



 Score =  118 bits (295), Expect = 4e-26
 Identities = 187/845 (22%), Positives = 322/845 (38%), Gaps = 110/845 (13%)

Query: 351  YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNG-SKI 409
            Y ++V   +   K  C+  V  T     P  P         K+S+  +W+ P+D+G S+I
Sbjct: 8282 YMIKVENDHGIAKAPCTVSVLDT-----PGPPINFVFEDIRKTSVLCKWEPPLDDGGSEI 8336

Query: 410  TNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTSG--YSQE 465
             NY LE  +  +          + +HCK  +TKL     Y FR+ A N  G      S+ 
Sbjct: 8337 INYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP 8396

Query: 466  VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP- 524
            +V       P  P  P +       + ++W++P+  +   ++ Y LE +E  + +     
Sbjct: 8397 LVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLEKREVNSTHWSRVN 8455

Query: 525  KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK---SCPSEVLVCTTSPDRPGPPTRPLVK 581
            K     L   V  L     Y FR+ A N  G    S PS+          PGPP   +  
Sbjct: 8456 KSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTD 8515

Query: 582  GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLKP 639
               T+    ++W+PP  NGG EI+ Y ++     +  N+W           +YT   ++ 
Sbjct: 8516 TSSTT--IELEWEPPAFNGGGEIVGYFVDKQLVGT--NEWSRCTEKMIKVRQYTVKEIRE 8571

Query: 640  GTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHL----EWDVP 695
            G  YKLR   ++  G     E+ PV   ++A  Q  P   L       + +       +P
Sbjct: 8572 GADYKLRVSAVNAAGEGPPGETQPV---TVAEPQEPPAVELDVSVKGGIQIMAGKTLRIP 8628

Query: 696  ASESGCEV-----SEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
            A  +G  V     ++   E+ +   V   V  G + E  + + L     R+ + A N  G
Sbjct: 8629 AVVTGRPVPTKVWTKEEGELDKDRVVIDNV--GTKSELIIKDALRKDHGRYVITATNSCG 8686

Query: 751  YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLE------ 803
                +   E+    GP    K P +  T     L+ W  P D  G++I+ + +E      
Sbjct: 8687 SKFAAARVEVFDVPGPVLDLK-PVV--TNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 8743

Query: 804  --WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL--VLCQTPAS 859
              W +  E+         ++ +I  LL   +Y  R+ A N+ G GP  E+  +L   P  
Sbjct: 8744 HTWRQPIETER-------SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 8796

Query: 860  APDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTI--------DLGDT 910
             P     L          Y +   + + L+W+EP  N GS I  Y I        D    
Sbjct: 8797 PPTSPERL---------TYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERV 8847

Query: 911  SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA--KTRPLPPL-------- 960
            +  +  TT  ++++L     Y  R++A+NEIG    S  +    +   +PP         
Sbjct: 8848 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVR 8907

Query: 961  ----------PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRG 1010
                      P  +     G    K++W  + +      D +   + E        + R 
Sbjct: 8908 GDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE--------VSRS 8959

Query: 1011 PSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
             + T   + +       ++ + A++  G   F   +     +  PP   A  VT ++  S
Sbjct: 8960 EAKTELSIPKAVREDKGTYTVTASNRLG-SVFRNVHVEVYDRPSPPRNLA--VTDIKAES 9016

Query: 1070 CEILWETVPSMKGDPVNYIL---QVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRV 1125
            C + W+      G  + + +   +    +++E+++V     E  + I  L  N  Y FRV
Sbjct: 9017 CYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRV 9076

Query: 1126 CACRR 1130
             A  +
Sbjct: 9077 RAVNK 9081



 Score =  118 bits (295), Expect = 4e-26
 Identities = 181/757 (23%), Positives = 289/757 (38%), Gaps = 115/757 (15%)

Query: 378   APECPFPP-KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH 435
             AP  P PP  ++     + +L W  P+ D GS ITNY++E  +  R          ++  
Sbjct: 12494 APGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTS 12553

Query: 436   CKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
             C++ KL P   Y FR+ A N  G S    S ++V      +P  P   R+ +     + +
Sbjct: 12554 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFV 12613

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKNLKRSTQYKFRLTA 550
              W +P+      +I Y +E    E ++L   K     +  T      L    +Y FR+ A
Sbjct: 12614 AWDRPDSDGGSPIIGYLIE--RKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYA 12671

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  G S PS+     T+     PP +P V   VT    S+ W  PK +GGS+I+ Y +E
Sbjct: 12672 LNKAGSSPPSKPTEYVTARMPVDPPGKPEVI-DVTKSTVSLIWARPKHDGGSKIIGYFVE 12730

Query: 611   I--TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTL 667
                  G+         +     EYT T L+    Y+ RA   +    S  SE S PV  L
Sbjct: 12731 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12790

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE 727
             +    +  PPR+      K       +   ++G  V   +    +P    S    G  L+
Sbjct: 12791 A----ENVPPRIDLSVAMK------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 12840

Query: 728   CTVG-------NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA----------GPPGQC 770
                G       NL   T+  F V   + G Y   ++ S  + +A          GPP   
Sbjct: 12841 PAEGIKMAMQRNLC--TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASV 12898

Query: 771   KAPCISCTPDGCVLVGWESP-DSSGADISEY--------RLEWGEDEESLELIYHGTDTR 821
             K   I+       ++ WE P +  G++I+ Y        R  W +   ++ +      T 
Sbjct: 12899 K---INKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI------TS 12949

Query: 822   FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDS 881
               +  L+   +Y  R+ A N+ G G               DPV T   + + P     D 
Sbjct: 12950 CSVEKLIEGHEYQFRICAENKYGVG---------------DPVFTEPAIAKNPY----DP 12990

Query: 882   PSAC------------LVLNWEEPCNN-GSEILAYTIDLGDTSITVGNTTMHVMKDLLPE 928
             P  C            + ++W+ P ++ GS I  Y ++  +T     N T    K ++  
Sbjct: 12991 PGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV--NWTKVNRKPIIER 13048

Query: 929   ----------TTYRIRIQAINEIGAGPFSQFIK---AKTRPLPPLPPRL-ECAAAGPQSL 974
                       T Y  R+ AIN+ G G  S   K   A+    PP PP   +       S+
Sbjct: 13049 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSV 13108

Query: 975   KLKWGDS--NSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQ 1031
              L WG    +  +     +V   + +  N    ++ +    T ++V  L E T Y FR+ 
Sbjct: 13109 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 13168

Query: 1032  AASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGN 1068
             A ++ G    S+       K  P  I  P   +L+ +
Sbjct: 13169 AVNKIGYSDPSDV----PDKHYPKDILIPPEGELDAD 13201



 Score =  118 bits (295), Expect = 4e-26
 Identities = 173/749 (23%), Positives = 277/749 (36%), Gaps = 83/749 (11%)

Query: 433   QKHCKLTKLCPAMGYTFRLAARNDIG--------TSGYSQEVVCYTLGNIPQMPSAP-RL 483
             + H K+ KL      T R     D G         +G + E +   + + P  P+ P ++
Sbjct: 23291 ETHTKVAKL------TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI 23344

Query: 484   VRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQ 543
                  T +T+ W  PE      +  Y +E ++           +    T     L    +
Sbjct: 23345 DEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNE 23404

Query: 544   YKFRLTASNTEG--KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y FR+ A+N  G      SEV+ C +S   PGPP   L    V+  G ++ W PP+D+GG
Sbjct: 23405 YVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPP-ETLQIFDVSRDGMTLTWYPPEDDGG 23463

Query: 602   SEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE- 660
             S++  Y++E  +  ++          + T Y  T L  G  Y+ R   I+  G  + S  
Sbjct: 23464 SQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRP 23523

Query: 661   SLPVRTLS--IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED--- 715
             S P+  +     PG+ + PRV    +   V L W VP  E G +V+ Y +EM + +    
Sbjct: 23524 SKPIVAMDPIAPPGKPQNPRVTDTTR-TSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEW 23582

Query: 716   VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCI 775
                        E T+ +L  G  YRFRV A N GG G  ++V         PG  K   +
Sbjct: 23583 TKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEV---------PGTVKVTEM 23633

Query: 776   SCTPD---------------GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDT 820
                PD               G V+            I ++  E  +  +   +    T T
Sbjct: 23634 LEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHT 23693

Query: 821   RFEIRDLLPAAQYCCRLQAFNQAGA-GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYP 879
                I++          L   N+ G    Y ++ +  +P S   P+             Y 
Sbjct: 23694 ELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLE------------YD 23741

Query: 880   DSPSACLVLNWEEPCNNG-SEILAYTIDLGDTSITVGNT-------TMHVMKDLLPETTY 931
             D     + ++W  P ++G ++IL Y ++  +       T       T  V+K L     Y
Sbjct: 23742 DIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEY 23801

Query: 932   RIRIQAINEIGAGP---FSQFIKAKTRPLPPLPPRL--ECAAAGPQSLKLKWGDSNSKTH 986
               R+ A N+ G        + +  KT   PP PP    E       S+ L W        
Sbjct: 23802 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGG 23861

Query: 987   AAEDIVYTLQLEDRNKRFISIYRGPSHT--YKVQRLTEFTCYSFRIQAASEAG---EGPF 1041
             +     Y  + E    +++   +    T  Y V  L     Y FRI A ++ G     P 
Sbjct: 23862 SRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPA 23921

Query: 1042  SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYK 1100
             SE          P       +  +  +S  + WE      G  +  Y ++     +S +K
Sbjct: 23922 SEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWK 23981

Query: 1101  QVYKG--EEATFQISGLQTNTDYRFRVCA 1127
             +  K   ++  F I GL   T+Y FRV A
Sbjct: 23982 KSNKERIKDKQFTIGGLLEATEYEFRVFA 24010



 Score =  117 bits (292), Expect = 9e-26
 Identities = 190/802 (23%), Positives = 298/802 (37%), Gaps = 63/802 (7%)

Query: 368   EPVSFTTHSCAPECPFPP---KLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNS 423
             EP   T    A E P PP    +   +KS+++L W  P  D GSKIT Y++E  + K + 
Sbjct: 14454 EPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIE-AQRKGSD 14512

Query: 424   GFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAP 481
              +          C +  L     YTF++ A N  G S    S+ V+      +P++    
Sbjct: 14513 QWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRG 14572

Query: 482   RLVRAGITWV--TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLK 539
                +  I      ++   P    P+  +T+    Q  +     + + T       +    
Sbjct: 14573 IYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECV 14632

Query: 540   RSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDN 599
             RS    + LTA N  G+    +V+      D PGPPT P+    V+S   +  WDPP+++
Sbjct: 14633 RSDSGPYPLTARNIVGEV--GDVITIQVH-DIPGPPTGPIKFDEVSSDFVTFSWDPPEND 14689

Query: 600   GGSEILKYLLEITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACC-----ISTG 653
             GG  I  Y++E+    +++  W E+A +   T Y  T L  G  Y+ R        +  G
Sbjct: 14690 GGVPISNYVVEMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPG 14747

Query: 654   GHSQC-SESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE 712
               S C   + P +     PG    P+V    K   + + W  P S+ G  +  Y VE  E
Sbjct: 14748 ITSACIVANYPFK----VPGPPGTPQVTAVTK-DSMTISWHEPLSDGGSPILGYHVERKE 14802

Query: 713   PEDVASEVYHGPELECTV---GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQ 769
                +  +      +   +     L  G  Y FRV A N  G    S  SE   A  P   
Sbjct: 14803 RNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDP 14862

Query: 770   CKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGEDEESLEL---IYHGTDTRFEIR 825
                P         V + W  P+ + G  I+ Y +E  +      L     +  +  F + 
Sbjct: 14863 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 14922

Query: 826   DLLPAAQYCCRLQAFNQAGA----GPYSELVLCQTPASAPDP------VSTLCVLEEEPL 875
              L   A Y  R+ A N AGA       S+ + C+    AP          T+ +   E  
Sbjct: 14923 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAF 14982

Query: 876   DAYPD-SPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR 934
                 D S      + W +            I + D S  + N      KD     +    
Sbjct: 14983 RLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVN------KDSTRRDSGAYT 15036

Query: 935   IQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
             + A N  G       +K   RP PP  P L       +   L W        A  D    
Sbjct: 15037 LTATNPGGFAKHIFNVKVLDRPGPPEGP-LAVTEVTSEKCVLSWFPPLDDGGAKIDHYIV 15095

Query: 995   LQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
              + E     + ++      T  KV +L +   Y FR+ A ++ G G P       +    
Sbjct: 15096 QKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPY 15155

Query: 1053  VPP-TIKAPRVTQLEGNSCEILWETVPSMKG-DPVNYILQVLVGRESEYKQVYKGEEAT- 1109
              PP   K P VT +  +S  + W    S  G + +NYI++    R+   ++  K  + T 
Sbjct: 15156 GPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVE---RRDKAGQRWIKCNKKTL 15212

Query: 1110  ----FQISGLQTNTDYRFRVCA 1127
                 +++SGL    +Y FR+ A
Sbjct: 15213 TDLRYKVSGLTEGHEYEFRIMA 15234



 Score =  117 bits (292), Expect = 9e-26
 Identities = 209/903 (23%), Positives = 342/903 (37%), Gaps = 101/903 (11%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             PQV+ +   ++ +SW  P+     P  G      Y V    K R+G      S   +  N
Sbjct: 14768 PQVTAVTKDSMTISWHEPLSDGGSPILG------YHV--ERKERNGILWQTVSKALVPGN 14819

Query: 342   LKDLRPATD---YHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +      TD   Y  RV A   + K   S+P          + P  P   + ++ ++TL+
Sbjct: 14820 IFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLK 14879

Query: 399   WKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGS-QKHCKLTKLCPAMGYTFRLAARND 456
             W  P    G KIT+Y++E  +       +  F    +    ++ L     Y FR+ A+N 
Sbjct: 14880 WAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNA 14939

Query: 457   IGT----SGYSQEVVCYTLGNIPQMPSAPR-----LVRAGITW-----------VTLQWS 496
              G     S  S  + C      P++    +     +++AG  +            T++WS
Sbjct: 14940 AGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS 14999

Query: 497   KPEGCSPEEVITYTLEIQ-EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
             K      E   T  LEI+  D + NL +            K+  R     + LTA+N  G
Sbjct: 15000 KD---GKELEGTAKLEIKIADFSTNLVN------------KDSTRRDSGAYTLTATNPGG 15044

Query: 556   KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
              +   + +      DRPGPP  PL    VTS    + W PP D+GG++I  Y+++  +  
Sbjct: 15045 FA---KHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRE-T 15100

Query: 616   SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQ 673
             S      VA     T+   T L  G  Y  R   ++  G  +  ES PV  ++    P  
Sbjct: 15101 SRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDP 15160

Query: 674   CRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTV 730
              + P V    K   V + W  P S+ G E+  Y VE  +      +        +L   V
Sbjct: 15161 PKNPEVTTITKDSMV-VCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKV 15219

Query: 731   GNLLPGTVYRFRVRALNDGGY------GPYSDVSEITTAAGPPGQCKAPCISCTPDGCVL 784
               L  G  Y FR+ A N  G        P+    +     GPPG    P +  T    + 
Sbjct: 15220 SGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSIS 15276

Query: 785   VGWESP-DSSGADISEYRLEWG---EDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQA 839
             + W  P    G++I+ Y +E     EDE  +     G   T + I  L    +Y  R+ A
Sbjct: 15277 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15336

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSE 899
              N  G G   E  L      A D +    +  +  L       + C +  +       + 
Sbjct: 15337 MNSEGLG---EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAP 15393

Query: 900   ILAYTIDLGDT--SITVGNTTMHVMKDLLPETTYRI---RIQAINEIGAGPFSQFIKAKT 954
              + +  D G++    ++ +T+ + +  L+     R    +     E  +G  S F+  + 
Sbjct: 15394 EVKWARDHGESLDKASIESTSSYTL--LIVGNVNRFDSGKYILTVENSSGSKSAFVNVRV 15451

Query: 955   RPLPPLPPRLECAAAGPQSLKLKW------GDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
                P  P  L+       S+ L W      G S  K +  E      + E   K + ++ 
Sbjct: 15452 LDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE------KRESTRKAYSTVA 15505

Query: 1009  RGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE- 1066
                  T +KV +L E   Y FR+ A +E G G  +E  T  + K+    +   ++T ++ 
Sbjct: 15506 TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE--TAESVKASERPLPPGKITLMDV 15563

Query: 1067  -GNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFR 1124
               NS  + WE      G  +  YI+++      ++      +     I+GL    +Y FR
Sbjct: 15564 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFR 15623

Query: 1125  VCA 1127
             V A
Sbjct: 15624 VSA 15626



 Score =  115 bits (288), Expect = 3e-25
 Identities = 177/727 (24%), Positives = 291/727 (40%), Gaps = 108/727 (14%)

Query: 384   PPKLAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFR--QCFFGSQKHC--KL 438
             P +++  S  S  L W  P D G ++ITNY++E    KR SG    Q    S K    K+
Sbjct: 22250 PIEVSSVSAESCVLSWGEPKDGGGTEITNYIVE----KRESGTTAWQLVNSSVKRTQIKV 22305

Query: 439   TKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS 496
             T L   M Y+FR+++ N  G S    S  ++       P  P+ P +       ++++W 
Sbjct: 22306 THLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE 22365

Query: 497   KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTE 554
             +P      ++I Y +E +++ N  L+  +     L C  K   L    +Y+FR  A N  
Sbjct: 22366 EPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAA 22424

Query: 555   GKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE---- 610
             G S  SE      + +    P RP V   VT    S+ W  P  +GGS+++ Y++E    
Sbjct: 22425 GVSKASEASRPIMAQNPVDAPGRPEVTD-VTRSTVSLIWSAPAYDGGSKVVGYIIERKPV 22483

Query: 611   --ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGH-SQCSESLPVRTL 667
               + DG      + +    S   +T T L  G  Y+ R    +  G  S+ SES      
Sbjct: 22484 SEVGDGRWLKCNYTIV---SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSEST----- 22535

Query: 668   SIAPGQCR----PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE--------- 714
                P  CR    PP+        +  L  D+    +G ++   +    +PE         
Sbjct: 22536 --GPVTCRDEYAPPKA-----ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGD 22588

Query: 715   ---DVASEV---YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPG 768
                D+  +V   Y G      +         ++ +   N  G    S + ++  + GP G
Sbjct: 22589 KELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCG 22648

Query: 769   QCKAPCISCTPDGCVLVGWESP-DSSGADISEYRLEWGEDEESLELIYHGT--DTRFEIR 825
             +     +  T + C L  W  P +  GA+I+ Y +E  E      +I  G      + + 
Sbjct: 22649 KLTVSRV--TQEKCTLA-WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVT 22705

Query: 826   DLLPAAQYCCRLQAFNQAGAGP--YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPS 883
              L+   +Y  R++A N+ G G    SE ++ +   + P P      + EE       +  
Sbjct: 22706 RLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG----IPEEV-----GTGK 22756

Query: 884   ACLVLNWEEP-CNNGSEILAYTIDLGDTS----------ITVGNTTMHVMKDLLPETTYR 932
               +++ W +P  + G+EI  Y +D  +              V +T + V   L+    Y+
Sbjct: 22757 EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTS-LMEGCDYQ 22815

Query: 933   IRIQAINEIG---AGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
              R+ A+N  G       S FI  +     P PP  PR+        S+ L W  +     
Sbjct: 22816 FRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRV--VDTTKHSISLAW--TKPMYD 22871

Query: 987   AAEDIV-YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTC--------YSFRIQAASEAG 1037
                DIV Y L++++++      YR   HT    R TEFT         YSFR+ A +  G
Sbjct: 22872 GGTDIVGYVLEMQEKDTD--QWYR--VHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 22927

Query: 1038  EGPFSET 1044
                +SE+
Sbjct: 22928 MSEYSES 22934



 Score =  114 bits (284), Expect = 7e-25
 Identities = 219/964 (22%), Positives = 367/964 (38%), Gaps = 124/964 (12%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             EKP+VSN+      +SW  PV        G S    Y V   +K      + I +   +L
Sbjct: 14079 EKPEVSNVTKNTATVSWKRPVD------DGGSEITGYHVERREKKSLRWVRAIKTPVSDL 14132

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH---RSKSSL 395
              C +  L+  + Y  RV A   +  G  SE         A   P PP   H    +K S 
Sbjct: 14133 RCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSA 14192

Query: 396   TLQWKAP-IDNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG 446
             +L W  P  D G +IT Y++E        W +    +  R   F       +  L     
Sbjct: 14193 SLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQF------VVPDLQTKEK 14246

Query: 447   YTFRLAARNDIGTSGYSQ----EVVCYTLGNIPQMPSAPR---LVRAGITWVTLQWSKPE 499
             Y FR++A ND G    +     E+V   +    ++ +  R   +VRAG++   ++   P 
Sbjct: 14247 YNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLS---IRIFVPI 14303

Query: 500   GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQY---KFRLTASNTEGK 556
                P   +T+T      +N NL +        + T+  +    +Y   KF +T  N  GK
Sbjct: 14304 KGRPAPEVTWT-----KDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK 14358

Query: 557   SCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS 616
                    V     D PGP    L    +T    ++ WD P  +GGS I  Y++E  +   
Sbjct: 14359 KSG---FVNVRVLDTPGPVLN-LRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATR 14414

Query: 617   EANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
             ++           T Y  T L  G  Y  R    +  G  + +E+      S AP     
Sbjct: 14415 KSYSTATTKCHKCT-YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS 14473

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLP 735
               ++   K   V L W  P  + G +++ Y +E   +  D  + +     LEC V NL  
Sbjct: 14474 LNIMDITK-STVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14532

Query: 736   GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             G  Y F+V A+N  G     +   +        Q   P +        LV  ++ D+   
Sbjct: 14533 GEEYTFQVMAVNSAGRSAPRESRPVIVKE----QTMLPELDLRGIYQKLVIAKAGDNIKV 14588

Query: 796   DI-----SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
             +I      +  + W + ++ L+         FE      A      +    ++ +GPY  
Sbjct: 14589 EIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVRSDSGPYP- 14640

Query: 851   LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP-------SACLVLNWEEPCNNGS-EILA 902
                  T  +    V  +  ++   +   P  P       S  +  +W+ P N+G   I  
Sbjct: 14641 ----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISN 14696

Query: 903   YTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP--FSQFIKA 952
             Y +++  T        + TV  TT    + L     Y+ R++A N  G GP   S  I A
Sbjct: 14697 YVVEMRQTDSTTWVELATTVIRTTYKATR-LTTGLEYQFRVKAQNRYGVGPGITSACIVA 14755

Query: 953   KTRPLPPLPPRL-ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNK---RFISIY 1008
                   P PP   +  A    S+ + W +  S    +  + Y ++ ++RN    + +S  
Sbjct: 14756 NYPFKVPGPPGTPQVTAVTKDSMTISWHEPLS-DGGSPILGYHVERKERNGILWQTVSKA 14814

Query: 1009  RGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEG 1067
               P + +K   LT+   Y FR+ A + AG+  P   +        + P  K P    +  
Sbjct: 14815 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGK-PVPLNITR 14873

Query: 1068  NSCEILWETVPSMKGDPV-NYILQ---VLVGR--ESEYKQVYKGEEATFQISGLQTNTDY 1121
             ++  + W       G  + +YI++   +  GR  ++ +  + + E   F +SGL  +  Y
Sbjct: 14874 HTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE---FTVSGLTEDAAY 14930

Query: 1122  RFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAA 1181
              FRV A        +  +GA SP +    + S+ +   D   ++ PK+K     D +F  
Sbjct: 14931 EFRVIA--------KNAAGAISPPS----EPSDAITCRD--DVEAPKIK----VDVKFKD 14972

Query: 1182  IIVL 1185
              ++L
Sbjct: 14973 TVIL 14976



 Score =  113 bits (283), Expect = 1e-24
 Identities = 196/861 (22%), Positives = 330/861 (38%), Gaps = 95/861 (11%)

Query: 325   RDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMY---NSVKGSCSEPVSFTTHSCAPEC 381
             R  K  ++Y   +    +  L    DY  RV A+    NS     S  +S    S  P  
Sbjct: 22791 RVNKDYVVY---DTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGP 22847

Query: 382   PFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK 440
             P  P++   +K S++L W  P+ D G+ I  Y+LE  E   +  +R     + ++ + T 
Sbjct: 22848 PSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 22907

Query: 441   LCPAMG--YTFRLAARNDIGTSGYSQ---EVVCYTLGNIPQMPSAPRL-----VRAGITW 490
                 MG  Y+FR+AA N  G S YS+   E+       IP +  A  L     +RAG   
Sbjct: 22908 PDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG--- 22964

Query: 491   VTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              +L+        P  VIT++ +  +  +  +     T       V  + R    K+ + A
Sbjct: 22965 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT--TESYSLLIVDKVNRYDAGKYTIEA 23022

Query: 551   SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              N  GK   +   V     D PGP     VK  V+    ++ W+ P  +GG+ +  Y++E
Sbjct: 23023 ENQSGKKSAT---VLVKVYDTPGPCPSVKVK-EVSRDSVTITWEIPTIDGGAPVNNYIVE 23078

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC---CISTGGHSQCSESLPVRTL 667
               +    A +  V    S T Y  + L  GT+Y  R         G   + S+++ V  +
Sbjct: 23079 KREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV 23137

Query: 668   SIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP--EDVASEVYHGPE 725
              + P +     V        V L W+ P  + G  ++ Y +E  +   E     V   P 
Sbjct: 23138 PLVPAKLEVVDVT----KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPT 23193

Query: 726   -LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCT------ 778
              LE TV +L  G  Y FR+RA N+ G    S+  E  TA         P I  +      
Sbjct: 23194 VLEHTVTSLNEGEQYLFRIRAQNEKGV---SEPRETVTAVTVQDLRVLPTIDLSTMPQKT 23250

Query: 779   ---PDG-----CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD--LL 828
                P G      + +    P ++    +  +L    + E + +  H    +  IR+  + 
Sbjct: 23251 IHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR---ESERVTVETHTKVAKLTIRETTIR 23307

Query: 829   PAAQYCCRLQAFNQAGAGPYS-ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV 887
                +Y   L+  N  G    + ++++   P     P+        + +DA        + 
Sbjct: 23308 DTGEYTLELK--NVTGTTSETIKVIILDKPGPPTGPIKI------DEIDA------TSIT 23353

Query: 888   LNWEEP-CNNGSEILAYTIDLGDT--------SITVGNTTMHVMKDLLPETTYRIRIQAI 938
             ++WE P  + G+ +  Y ++  D         S +V  +T    + L     Y  R+ A 
Sbjct: 23354 ISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTR-LTEGNEYVFRVAAT 23412

Query: 939   NEIGAGPF--SQFIKAKTRPLPPLPPR-LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTL 995
             N  G G +  S+ I+ ++    P PP  L+        + L W        +        
Sbjct: 23413 NRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE 23472

Query: 996   QLEDRNKRFISIYRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKS 1052
             + E R  R++ + + P     Y+   LTE   Y  R+ A +  G G P   +        
Sbjct: 23473 RKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDP 23532

Query: 1053  VPPTIKA--PRVTQLEGNSCEILWETVPSMKGDPVN-YILQVLVGRESEYKQ--VYKGEE 1107
             + P  K   PRVT     S  + W       G  V  Y++++    + E+ +      + 
Sbjct: 23533 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKI 23592

Query: 1108  ATFQISGLQTNTDYRFRVCAC 1128
               + ++ L    +YRFRV AC
Sbjct: 23593 REYTLTHLPQGAEYRFRVLAC 23613



 Score =  112 bits (281), Expect = 2e-24
 Identities = 187/798 (23%), Positives = 293/798 (36%), Gaps = 83/798 (10%)

Query: 382   PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P PP+   ++   K S  L WK P+D+G S ITNY++E  +   ++ +      S+K   
Sbjct: 10813 PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKKSH 10871

Query: 438   LTK-LCPAMGYTFRLAARNDIGTSGYSQE---VVCYTLGNIPQMPSAPRLVRAGITWVTL 493
               K L     Y FR+AA N  G   + +    +      + P  P     V    T V+L
Sbjct: 10872 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 10931

Query: 494   QWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
              W+KP+      +  Y +E QE+   +    K T  +L C V  L++   Y+FR+ A N 
Sbjct: 10932 VWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAENI 10990

Query: 554   EGKSCPSEVLVCTTSPDRPGPPTR---PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
              G   P   +          P       L++G V   G +V++            K+   
Sbjct: 10991 VGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-- 11048

Query: 611   ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              TDG SE    E         YT       ++  ++ C     G  Q + S    + ++A
Sbjct: 11049 -TDG-SEIKTDE--------HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVA 11098

Query: 671   --------PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVY 721
                     PG    P  +     + + + W  P  + G  V  Y VE  +  +D    V 
Sbjct: 11099 VHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVS 11158

Query: 722   HGP-ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA---GPPGQCKAPCISC 777
              G  + +  + +L  G  Y FRVRA N  G GP  D S  T A     PP     P ++ 
Sbjct: 11159 SGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLD-STPTVAKHKFSPPSPPGKPVVTD 11217

Query: 778   TPDGCVLVGWESPDSSGAD-ISEYRLEWGEDEESLELIYHG--TDTRFEIRDLLPAAQYC 834
               +    V W  P S G   I+ Y +E  E       +      D +F +  L     Y 
Sbjct: 11218 ITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 11277

Query: 835   CRLQAFNQAGAG---PYSELVLCQTPASAPDPVSTLCVLEEEPLDA-YPDSPSACLVLNW 890
              R+ A N AG     P S+ +    P   P P          P++    D       L W
Sbjct: 11278 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGP----------PINPKLKDKSRETADLVW 11327

Query: 891   EEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKD------------LLPETTYRIRIQA 937
              +P ++G S IL Y ++         N    + KD            L+    YR RI+A
Sbjct: 11328 TKPLSDGGSPILGYVVECQKPGTAQWN---RINKDELIRQCAFRVPGLIEGNEYRFRIKA 11384

Query: 938   INEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGD-----SNSKTHAAEDIV 992
              N +G G   +  ++        PP +E        + ++ G      +  K     DI 
Sbjct: 11385 ANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDIT 11444

Query: 993   YTLQ--LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             +T +  +  R KR   I   P    +++         + I A + +G    S        
Sbjct: 11445 WTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGS---AIVNV 11501

Query: 1051  KSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEAT 1109
                P   +  +VT +   +C I WE      G  + N+I++     +  +  V       
Sbjct: 11502 LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11561

Query: 1110  FQISGLQTNTDYRFRVCA 1127
                + L  N +Y FRVCA
Sbjct: 11562 LIKANLLANNEYYFRVCA 11579



 Score =  112 bits (279), Expect = 3e-24
 Identities = 202/906 (22%), Positives = 332/906 (36%), Gaps = 95/906 (10%)

Query: 280   EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EEL 338
             + P+V+ +    + + W PP       + G      Y +   +K       +  S   E 
Sbjct: 11903 DPPEVTKVSKEEMTVVWNPP------EYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPER 11956

Query: 339   ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP---KLAHRSKSSL 395
                +++L P  +Y  RV A      G  S P          E P PP   ++   +K S+
Sbjct: 11957 RMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSI 12016

Query: 396   TLQWKAPI-DNGSKITNYLLEWD----EGKRNSGFRQCFFGSQ---KHCKLTKLCPAMGY 447
             TL W  P+ D G+ I  Y++E      +   + G+++C   +Q   K   +T L     Y
Sbjct: 12017 TLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEY 12076

Query: 448   TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR--------LVRAG--ITWVTLQWSK 497
              FR+ A+N +G    ++         I + P            +VRAG  I    +   +
Sbjct: 12077 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 12136

Query: 498   PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKS 557
             P        +     +++ + D +    +        + N  R    K+ LT  N  G+ 
Sbjct: 12137 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFL------VIPNSTRDDSGKYSLTLVNPAGEK 12190

Query: 558   CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
                 V V     D PGP +  L    VT     V W PP+++GGS++  Y++E  +  ++
Sbjct: 12191 A---VFVNVRVLDTPGPVS-DLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKRE--AD 12244

Query: 618   ANQWE-VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP-GQCR 675
                W  V      T +  T+L PG  Y  R   ++  G    ++ +P   L+  P  +  
Sbjct: 12245 RKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTD-VPKPVLASDPLSEPD 12303

Query: 676   PPRVL--GRPKHKEVHLEWDVPASESGCEVSEYSV---EMTEPEDVASEVYHGPELECTV 730
             PPR L           L W  P  + G ++  Y     E  +P D  +E     +L   V
Sbjct: 12304 PPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVV 12363

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE-- 788
               L  G  Y+FRV A N  G     +   +  A     Q   P I       +  G +  
Sbjct: 12364 TGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA---KEQLLPPKILMPEQITIKAGKKLR 12420

Query: 789   -SPDSSGADISEYRLEWGEDE--ESLELIYHGTDTR--FEIRDLLPAAQYCCRLQAFNQA 843
                   G      + + GEDE   S  L  H  D+     I+D+         L A N +
Sbjct: 12421 IEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12480

Query: 844   GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILA 902
             G       V+       P P          P D       AC  L+W  P  + GS I  
Sbjct: 12481 GTDTQKIKVVVMDAPGPPQP----------PFDISDIDADAC-SLSWHIPLEDGGSNITN 12529

Query: 903   YTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAK 953
             Y ++  D S         +V  T+  V K L+P   Y  R++A N  G + P +      
Sbjct: 12530 YIVEKCDVSRGDWVTALASVTKTSCRVGK-LIPGQEYIFRVRAENRFGISEPLTSPKMVA 12588

Query: 954   TRP--LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN-----KRFIS 1006
               P  +P  P            + + W D       +  I Y ++ ++RN     K   +
Sbjct: 12589 QFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLIERKERNSLLWVKANDT 12647

Query: 1007  IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
             + R  S  Y    L E   YSFRI A ++AG  P S+   + T +        P V  + 
Sbjct: 12648 LVR--STEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVT 12705

Query: 1067  GNSCEILWETVPSMKGDP-VNYILQVLVGRESEYKQV----YKGEEATFQISGLQTNTDY 1121
              ++  ++W       G   + Y ++       ++ +     ++  +  +  +GL+    Y
Sbjct: 12706 KSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQY 12765

Query: 1122  RFRVCA 1127
             +FR  A
Sbjct: 12766 QFRAIA 12771



 Score =  109 bits (273), Expect = 1e-23
 Identities = 207/916 (22%), Positives = 353/916 (38%), Gaps = 89/916 (9%)

Query: 284   VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLK 343
             V  ++  +  L W PP+        G +   +Y +   +  R     +     +    ++
Sbjct: 17627 VKEVRKDSAFLVWEPPI------IDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVE 17680

Query: 344   DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
             +L     Y+ RV A      G   E V     +  P  P    L   S++S +L W+ P 
Sbjct: 17681 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17740

Query: 404   -DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTS 460
              D GS++  Y++E          +       K C   +T L     Y FR+ A N+ G S
Sbjct: 17741 HDGGSRVLGYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS 17797

Query: 461   G---YSQEVVCYTLGNIP--QMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE 515
                     V+   L   P  ++P     ++AG     L+   P    P   I++  + + 
Sbjct: 17798 DPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAG---EDLKIEIPVIGRPRPNISWVKDGEP 17854

Query: 516   DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              +     + + T       +K   +    K+ +TA+N+ G +  +  ++     ++PGPP
Sbjct: 17855 LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL---EKPGPP 17911

Query: 576   TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE-VAYSGSATEYTF 634
               P+    V++    + W+PP   GG +I  Y++E  D  +    W  V+ + + T    
Sbjct: 17912 VGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRD--TTTTTWHMVSATVARTTIKI 17969

Query: 635   THLKPGTLYKLRACCISTGGHSQ--CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEW 692
             T LK GT Y+ R    +  G S    S+++ V+     PG    P V    K  ++ ++W
Sbjct: 17970 TKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISK-DQMLVQW 18028

Query: 693   DVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECT---VGNLLPGTVYRFRVRALNDG 749
               P ++ G ++  Y +E  E   +     +   ++ T      L  G  Y F+V A N  
Sbjct: 18029 HEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIV 18088

Query: 750   GYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWG 805
             G G  S VSE   A     PPG+ +A  I+      V + W+ P    G+ I+ Y +E  
Sbjct: 18089 GIGKPSKVSECFVARDPCDPPGRPEAIVIT---RNNVTLKWKKPAYDGGSKITGYIVEKK 18145

Query: 806   E--DEESLELIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAG--------AGPYSELVLC 854
             +  D   ++  +    +T F +  L+   +Y  R+ A N AG        +G  +     
Sbjct: 18146 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEI 18205

Query: 855   QTPASAPDP----VSTLCVLEEEPLDA-YPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
               P ++ DP    V  +   E   L+A     P   +V  W +   +G E L  T    +
Sbjct: 18206 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVV--WSK---DGKE-LEETAARME 18259

Query: 910   TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAA 969
                T+  TT+ V+KD +     +  ++  N  G       +K   RP PP  P L+    
Sbjct: 18260 IKSTIQKTTL-VVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP-LKVTGV 18317

Query: 970   GPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSH----TYKVQRLTEFTC 1025
               +   L W   N         +    +E R    +S  +  +      YKV +L     
Sbjct: 18318 TAEKCYLAW---NPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNE 18374

Query: 1026  YSFRIQAASEAGEGPFSET--YTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             Y FR+ A ++ G G   E+   T       P     P V+ +  +S  + W       G 
Sbjct: 18375 YIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGT 18434

Query: 1084  PV-NYILQVLVGRESEYKQVYKGEEAT-----FQISGLQTNTDYRFRVCACRRCLDTSQE 1137
              +  YIL+    R+ E  +  K  + T      +++GL     Y FRV A        + 
Sbjct: 18435 EIEGYILE---KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAA--------EN 18483

Query: 1138  LSGAFSPSAAFVLQRS 1153
              +G   PS   V  R+
Sbjct: 18484 AAGVGEPSEPSVFYRA 18499



 Score =  109 bits (272), Expect = 2e-23
 Identities = 217/913 (23%), Positives = 347/913 (38%), Gaps = 114/913 (12%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +V+N+      +SW  P  L  G     +F   Y      K     + I+ S        
Sbjct: 11512 KVTNVTKENCTISWENP--LDNGGSEITNFIVEYR-----KPNQKGWSIVASDVTKRLIK 11564

Query: 343   KDLRPATDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
              +L    +Y+ RV A      G   E   P+        P  P    +A + K+ + L+W
Sbjct: 11565 ANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKW 11624

Query: 400   KAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK--HCKLTKLCPAMGYTFRLAARND 456
             + P  D GS   +Y +E    K +  + +   GS K  H  + +      Y FR+  +N+
Sbjct: 11625 RRPDYDGGSPNLSYHVE-RRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 11683

Query: 457   IGTSGY--SQEVVCYTLGNIPQMP---SAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
              G S +  ++EVV       P +    S    V+AG T + L+        PE  + +T 
Sbjct: 11684 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDT-IRLEAGVRGKPFPE--VAWTK 11740

Query: 512   EIQEDENDNLFHPKYT----GEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +  +D  D    P+       +    ++   KRS   K+ +TA+NT G    S V   T 
Sbjct: 11741 D--KDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG----SFVAYATV 11794

Query: 568   SP-DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
             +  D+PGP  R L    V+S   +V WDPP+D+GG EI  Y+LE  +  ++   W   YS
Sbjct: 11795 NVLDKPGP-VRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCE--TKRMVWS-TYS 11850

Query: 627   GSATE--YTFTHLKPGTLYKLRACCISTGGHSQCSESLPV--RTLSIAPGQCRPPRVLGR 682
              +      T T L  G  Y  R    +  G    +ES PV  +T    PG+  PP V  +
Sbjct: 11851 ATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-K 11909

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPED---VASEVYHGPELECTVGNLLPGTVY 739
                +E+ + W+ P  + G  ++ Y +E  E      V       PE    V NLLP   Y
Sbjct: 11910 VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEY 11969

Query: 740   RFRVRALNDGGYGPYSDVSEITTAAG---PPGQCKAPCISCTPDGCVLVGWESP-DSSGA 795
             +FRV+A N+ G G  S  S    A     PPG      +  T    + +GW  P    GA
Sbjct: 11970 QFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGA 12029

Query: 796   DISEYRLE-------------WGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQ 842
              I  Y +E             W     + +L+       F +  L    +Y  R+ A NQ
Sbjct: 12030 PIIGYVVEMRPKIADASPDEGWKRCNAAAQLV----RKEFTVTSLDENQEYEFRVCAQNQ 12085

Query: 843   AGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
              G G          PA   + +    +LE   +D   D+    LV+        G  I  
Sbjct: 12086 VGIG---------RPAELKEAIKPKEILEPPEIDL--DASMRKLVI-----VRAGCPIRL 12129

Query: 903   YTIDLGDTS-------ITVGNTTMHVMKDL--------LPETTY----RIRIQAINEIGA 943
             + I  G  +       + + N       DL        +P +T     +  +  +N   A
Sbjct: 12130 FAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP--A 12187

Query: 944   GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR 1003
             G  + F+  +    P     L+ +     S  + W    +   +        + E   K 
Sbjct: 12188 GEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT 12247

Query: 1004  FISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG---PFSETYTFSTTKSVPPTIKA 1059
             + ++      T + V  L     Y FR+ A +E G G      +    S   S P   + 
Sbjct: 12248 WSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRK 12307

Query: 1060  PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE-----YKQVYKGEEATFQISG 1114
               VT++  NS  + W  +P ++         +   RE E     + +    ++ +  ++G
Sbjct: 12308 LEVTEMTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG 12365

Query: 1115  LQTNTDYRFRVCA 1127
             L+    Y+FRV A
Sbjct: 12366 LKEGKKYKFRVAA 12378



 Score =  108 bits (271), Expect = 2e-23
 Identities = 153/654 (23%), Positives = 249/654 (38%), Gaps = 100/654 (15%)

Query: 382  PFPPK---LAHRSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGS--QKH 435
            P PP+   +      S  L W AP+DNG S+IT+Y+++  +  R     +    +  +K 
Sbjct: 9001 PSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKR 9060

Query: 436  CKLTKLCPAMGYTFRLAARNDIGTSGY--SQEVVCYTLGNIPQMPSAPRLVRAGITWVTL 493
              + KL P   Y FR+ A N  G S    S +VV      +P  P  P+++      + +
Sbjct: 9061 YGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLV 9120

Query: 494  QWSKPEGCSPEEVITYTLEIQEDENDNLFH------PKYTGEDLTCTVKNLKRSTQYKFR 547
             W+ P       +  Y LE +E+ +            K   + +   V  L    +Y+FR
Sbjct: 9121 SWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFR 9180

Query: 548  LTASNTEGKSCPSEVLVCTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEI 604
              A N  G   PSE      + D    PGPP+ P VK   T    S+ W PP  +GGS I
Sbjct: 9181 AMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDK-TKSSISLGWKPPAKDGGSPI 9239

Query: 605  LKYLLEITDGNSEANQWEVAYSG----SATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
              Y++E+ +  +    W+         +  E    +LK    Y+ R   ++  G S+ S+
Sbjct: 9240 KGYIVEMQEEGT--TDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSD 9297

Query: 661  S---LPVRTLSIAP-----------------GQCRPPRVL-GRPKHKEVHLEWDVPA-SE 698
            +   +P   +   P                  Q R P V+ GRP  K     W+    ++
Sbjct: 9298 TTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKS---SWEFDGKAK 9354

Query: 699  SGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVS 758
               +   + +    PED   E      +   +         ++ + A N  G    +   
Sbjct: 9355 KAMKDGVHDI----PEDAQLETAENSSV-IIIPECKRSHTGKYSITAKNKAGQKTANCRV 9409

Query: 759  EITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGAD-ISEYRLEWG--EDEESLELIY 815
            ++    GPP   K   +S    G   + W+ PD  G D I  Y +E    + +   ++  
Sbjct: 9410 KVMDVPGPPKDLK---VSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNP 9466

Query: 816  HGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPL 875
                T F + DLL   QY  R++A N+ G GP  E +   T   A DP+           
Sbjct: 9467 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT---ARDPI----------- 9512

Query: 876  DAYPDSPSACLV----------LNWEEPCNNG-SEILAYTIDL--GDTSITVGNT----- 917
              YP  P   L           L+W+ P N+G S +  Y ++    D + T         
Sbjct: 9513 --YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCN 9570

Query: 918  ------TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLE 965
                      ++DL+    Y  R++A+N  G    S  +       P +PP ++
Sbjct: 9571 KRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 9624



 Score =  103 bits (256), Expect = 1e-21
 Identities = 216/952 (22%), Positives = 362/952 (38%), Gaps = 106/952 (11%)

Query: 280  EKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE 339
            +KP V ++ + ++++ W  P   +  P  G       EV  +   R  K  +      L+
Sbjct: 8410 DKPIVEDVTSNSMLVKWNEPKD-NGSPILGYWLE-KREVNSTHWSRVNKSLL----NALK 8463

Query: 340  CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVS-FTTHS-CAPECPFPPKLAHRSKSSLTL 397
             N+  L     Y  RV A   +  G  S P    T H   +P  P  P++   S +++ L
Sbjct: 8464 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIEL 8523

Query: 398  QWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK-----LCPAMGYTFRL 451
            +W+ P  NG  +I  Y ++    K+  G  +    ++K  K+ +     +     Y  R+
Sbjct: 8524 EWEPPAFNGGGEIVGYFVD----KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 8579

Query: 452  AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL---VRAGITWV---TLQWSKPEGCSPEE 505
            +A N  G  G   E    T+   PQ P A  L   V+ GI  +   TL+        P  
Sbjct: 8580 SAVNAAG-EGPPGETQPVTVAE-PQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVP 8637

Query: 506  VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
               +T E  E + D +      G      +K+  R    ++ +TA+N    SC S+    
Sbjct: 8638 TKVWTKEEGELDKDRVVIDN-VGTKSELIIKDALRKDHGRYVITATN----SCGSKFAAA 8692

Query: 566  TTSP-DRPGPPTRPLVKGPVTSHGFSV-KWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
                 D PGP     +K  VT+    +  W  P+D+GGSEI  +++E  D  ++ + W  
Sbjct: 8693 RVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKD--AKMHTWRQ 8748

Query: 624  AYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP 683
                  ++   T L  G  YK R    +  G     E  P+  +        P R+    
Sbjct: 8749 PIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTE 8808

Query: 684  KHKE-VHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG---PELECTVGNLLPGTVY 739
            + K  + L+W  P S  G  +  Y +E    +    E  +    P     V NL    +Y
Sbjct: 8809 RTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMY 8868

Query: 740  RFRVRALND-GGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS 798
             FRV+A+N+ G   P   ++ +      P   K   +S   D  + V    P    AD++
Sbjct: 8869 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLR-LSVRGD-TIKVKAGEPVHIPADVT 8926

Query: 799  EY---RLEWGEDEESL------------ELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
                 ++EW ++E  +            E+      T   I   +   +    + A N+ 
Sbjct: 8927 GLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRL 8986

Query: 844  GAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN-GSEILA 902
            G+   +  V        P P   L V + +    Y         L W+ P +N GSEI  
Sbjct: 8987 GSVFRNVHV---EVYDRPSPPRNLAVTDIKAESCY---------LTWDAPLDNGGSEITH 9034

Query: 903  YTIDLGDTS------ITVGNTTM---HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAK 953
            Y ID  D S        V NT +   + +  L+P   Y  R++A+N+ G     +  K  
Sbjct: 9035 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVV 9094

Query: 954  TR-----PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIY 1008
             +     P PP  P++     G  S+ + W        +     +  + E+ +  +  + 
Sbjct: 9095 IQDPYRLPGPPGKPKVLARTKG--SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVS 9152

Query: 1009 RGP-------SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS---VPPTIK 1058
            R P          + V RL E   Y FR  A + AG GP SE             P    
Sbjct: 9153 RAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPS 9212

Query: 1059 APRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEE----ATFQIS 1113
             P V     +S  + W+      G P+  YI+++     +++K+V + ++        + 
Sbjct: 9213 CPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVP 9272

Query: 1114 GLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLD 1165
             L+    YRFRV A     ++    +    P A  + +  EV +  D+G+ D
Sbjct: 9273 NLKELRKYRFRVKAVNEAGESEPSDTTGEIP-ATDIQEEPEVFI--DIGAQD 9321



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 204/939 (21%), Positives = 334/939 (35%), Gaps = 131/939 (13%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEEL------- 338
            ++ A+    +  PP  L+    +       +E   +D GR  +  +I   E L       
Sbjct: 7677 SVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKA 7736

Query: 339  ------ECNLK--DLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH- 389
                  +CN +  D+   T+   +V A   +  G  SEP    +       P PP   H 
Sbjct: 7737 GKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV 7796

Query: 390  --RSKSSLTLQWKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTK------ 440
                +  + + WK P  NG S I  Y +E            C  G++K  ++        
Sbjct: 7797 TDAGRKHIAIAWKPPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNSRPIKDL 7845

Query: 441  -------LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVT- 492
                   + P   Y  R+ A N IG S  S E+    +   P       L    I  +  
Sbjct: 7846 KFKVEEGVVPDKEYVLRVRAVNAIGVSEPS-EISENVVAKDPDCKPTIDLETHDIIVIEG 7904

Query: 493  --LQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              L    P    P   +++  + +E +  +    K         V    R+    + +T 
Sbjct: 7905 EKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITL 7964

Query: 551  SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 610
             N  G +  S  +     P     P + +    +T     + W+PP+ +GG+ IL Y+LE
Sbjct: 7965 ENKLGSATASINVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 8020

Query: 611  ITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA 670
              +         V    +   +T   L P   Y  R   ++  G  +  E L    ++  
Sbjct: 8021 RREA-GRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE-LKNPVIAQD 8078

Query: 671  PGQCRPPRV---LGRPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGP 724
            P Q   P V   +  P  + + + W  P  + G ++  Y +E     E        +  P
Sbjct: 8079 PKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 8138

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKA------------ 772
             L  T   L  G  Y+FRVRA N  G    S  +  T A  P    K             
Sbjct: 8139 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGD 8198

Query: 773  -------------PCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEE---------S 810
                         P I+   D  V+V  E    +   +   + E  E+E          S
Sbjct: 8199 EIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLS 8258

Query: 811  LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
            ++    G +++  +RD L        ++  N  G             A AP  VS L   
Sbjct: 8259 IDNSKKG-ESQLRVRDSLRPDHGLYMIKVENDHGI------------AKAPCTVSVLDTP 8305

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNN-GSEILAYTIDLGDTS------ITVGNTTMHV-- 921
                   + D     ++  WE P ++ GSEI+ YT++  D +      I V +T  H   
Sbjct: 8306 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY 8365

Query: 922  -MKDLLPETTYRIRIQAINEIGAGP--FSQFIKAKTRPLPP-LPPRLECAAAGPQSLKLK 977
             +  L+    Y  R++A N  G GP   S+ + AK    PP  P +         S+ +K
Sbjct: 8366 SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVK 8425

Query: 978  WGDSNSKTHAAEDIVYTLQLEDRNKRFIS-IYRGPSHTYK--VQRLTEFTCYSFRIQAAS 1034
            W +   K + +  + Y L+  + N    S + +   +  K  V  L E   Y FR+ A +
Sbjct: 8426 WNE--PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAEN 8483

Query: 1035 EAGEGPFSETYTFSTTKS--VPPTIKAPRVTQLEGNSCEILWETVPSMK--GDPVNYILQ 1090
             AG G FS      T      PP    PRVT     + E+ WE  P+    G+ V Y + 
Sbjct: 8484 AAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEP-PAFNGGGEIVGYFVD 8542

Query: 1091 VLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
              +   +E+ +  +   +   + +  ++   DY+ RV A
Sbjct: 8543 KQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA 8581



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 90/306 (29%), Positives = 137/306 (44%), Gaps = 22/306 (7%)

Query: 283   QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNL 342
             +  +IQ R+V +SW PP         G +    Y +   +  +   Y I          +
Sbjct: 23739 EYDDIQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLVV 23792

Query: 343   KDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPF-PPKLAHRSKSSLTLQ 398
             K L+   +YH RV A      S      EPV+  T    PE P  PP++   +KSS++L 
Sbjct: 23793 KGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLS 23852

Query: 399   WKAPIDNG-SKITNYLLEWDEGKRNSGFRQCFFG-SQKHCKLTKLCPAMGYTFRLAARND 456
             W  P D+G S++T Y +E  E   +   R      +     +T L P   Y FR+ A+ND
Sbjct: 23853 WSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQND 23912

Query: 457   IG---TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEI 513
             +G   TS  S+ VVC    + P  P    ++      VTLQW KPE    +E++ Y +E 
Sbjct: 23913 VGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEY 23972

Query: 514   QEDENDNLFHP--KYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC----TT 567
             ++   D+ +    K   +D   T+  L  +T+Y+FR+ A N  G S P    +      T
Sbjct: 23973 RQS-GDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLT 24031

Query: 568   SPDRPG 573
             S + PG
Sbjct: 24032 SGEAPG 24037



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 188/836 (22%), Positives = 298/836 (35%), Gaps = 141/836 (16%)

Query: 380   ECPFPPK---LAHRSKSSLTLQWKAPIDN-GSKITNYLLE--------WDEGKRNSGFRQ 427
             + P PPK   ++  ++ S  L WK P D+ G +I  Y++E        W +   + G   
Sbjct: 9413  DVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCG--- 9469

Query: 428   CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL-VRA 486
                       +  L     Y FR+ A N  G  G   E +  T    P  P  P + ++ 
Sbjct: 9470  -----STTFVVPDLLSEQQYFFRVRAENRFGI-GPPVETIQRTTARDPIYPPDPPIKLKI 9523

Query: 487   GI---TWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP------KYTGEDLTCTVKN 537
             G+     V L W  P+      V  Y +E    +             K   E+L  TV++
Sbjct: 9524  GLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 9583

Query: 538   LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVK----- 592
             L    +Y+FR+ A N  G S PS  +          PP+  L +      G +V      
Sbjct: 9584  LVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKI 9643

Query: 593   ---------W--DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGT 641
                      W   PPK     E + Y       ++  N+  V  + +           G 
Sbjct: 9644  KGVPFPTLTWFKAPPKKPDNKEPVLY-------DTHVNKLVVDDTCTLVIPQSRRSDTG- 9695

Query: 642   LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
             LY + A           S+ + +  L   PG    P         ++ L W  P  + G 
Sbjct: 9696  LYTITA----VNNLGTASKEMRLNVLG-RPGPPVGPIKFESVSADQMTLSWFPPKDDGGS 9750

Query: 702   EVSEYSVEMTEPEDVASEVYHGPELEC--TVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
             +++ Y +E  E              EC  T+  LL G  Y FR+ A N  G G   D SE
Sbjct: 9751  KITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLD-SE 9809

Query: 760   ITTAA---GPPGQCKAPCISCTPDGCVLVGWESPD-SSGADISEYRLEWGE--------- 806
               TA      PG    P +S      + V WE P+   G+ ++ Y LE  +         
Sbjct: 9810  PETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 9869

Query: 807   DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
             + + ++ +  G    +++  L+  + Y  R+ A N AG GP S   L   PA+A DP++ 
Sbjct: 9870  NRDPIKAMTLGVS--YKVTGLIEGSDYQFRVYAINAAGVGPAS---LPSDPATARDPIAP 9924

Query: 867   LCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGSEILAYTIDL---GDTSITVGNT----- 917
                    P     D   +   L W  P  + GS++  Y ++    G      G       
Sbjct: 9925  ----PGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 9980

Query: 918   TMHVMKDLLPETTYRIRIQAINEIG---AGPFSQFIKAKTRPLPPLPP------------ 962
             T  V+  L     Y+ R++A+N  G    G  +  I+ K R + P               
Sbjct: 9981  TKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVH 10040

Query: 963   -----RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKV 1017
                  R+    +G     + W + N +T   E  + T  +              S   K 
Sbjct: 10041 AGGVIRIIAYVSGKPPPTVTW-NMNERTLPQEATIETTAISS------------SMVIKN 10087

Query: 1018  QRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVT-QLEGNSCEILWET 1076
              + +    YS  + A +EAGE    +         VP  +  P +   L   SC++ W +
Sbjct: 10088 CQRSHQGVYS--LLAKNEAGE---RKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 10142

Query: 1077  VPSMKGDPV-NYILQVLVGRESEYKQ----VYKGEEATFQISGLQTNTDYRFRVCA 1127
                  G P+ NY+++    RES+ +      Y        + GL     Y FR+ A
Sbjct: 10143 PEDDGGSPITNYVIE---KRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAA 10195



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 217/939 (23%), Positives = 341/939 (36%), Gaps = 118/939 (12%)

Query: 271  RVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK 330
            +V D+   +   +V+      V L+W  P+        G S    Y V   D  R     
Sbjct: 6588 KVIDVPGPVRNLEVTETFDGEVSLAWEEPLT------DGGSKIIGYVVERRDIKRKTWVL 6641

Query: 331  IIYSGEELECNLKDLRPA-TDYHVRVYAMYNSVKGSCSE---PVSFTTHSCAPECPFPPK 386
                 E  E  +  L+    +Y  RV A      G   E   PV   +    P  P    
Sbjct: 6642 ATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVT 6701

Query: 387  LAHRSKSSLTLQWKAP-IDNGSKITNYLLEW-DEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
            +   ++  ++L W+ P  D G++ITNY++E  D+                   +T +   
Sbjct: 6702 ITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEG 6761

Query: 445  MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITW--VTLQWSKP--E 499
              Y+FR+ A+N IG    S       + +  + PS P  L  +  T   V L+W  P  +
Sbjct: 6762 QEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKD 6821

Query: 500  GCSPEEVITYTLEIQEDENDNLFHPKYT-GEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
            G SP  ++ Y +E  E+  DN          +LT  V  L++  +Y +R++A N  G S 
Sbjct: 6822 GGSP--ILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSD 6879

Query: 559  PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
            PSE+L   T+ D    PT  L        G  V    P        +  L+  T      
Sbjct: 6880 PSEILGPLTADDAFVEPTMDL---SAFKDGLEVIVPNP--------ITILVPSTGYPRPT 6928

Query: 619  NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQ-----CSESLPVRTLS----- 668
              W     G     T   +K  TL       IS    S            V+T+S     
Sbjct: 6929 ATW---CFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDV 6985

Query: 669  --IAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE--PEDVASEVYHGP 724
              IA          G      VHL W+ P  + G  ++ Y VE  E   +     +    
Sbjct: 6986 NVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT 7045

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE---ITTAAGPPGQCKAPCISCTPDG 781
            +LE TV +L+ G  Y F+V A N  G G  + V E   ++T A  P   +          
Sbjct: 7046 DLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN 7105

Query: 782  CVLVGWESP-DSSGADISEYRLE--------WGEDEESLELIYHGTDTRFEIRDLLPAAQ 832
             + + W+ P +  G+ I  Y +E        W    E +       +T+ E+  L     
Sbjct: 7106 SIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPV------AETKMEVTGLEEGKW 7159

Query: 833  YCCRLQAFNQAGAG----PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL 888
            Y  R++A N+ GA     P  E+    T   AP+    + +L    + A         V 
Sbjct: 7160 YAYRVKALNRQGASKPSRPTEEIQAVDT-QEAPEIFLDVKLLAGLTVKAGTKIELPATVT 7218

Query: 889  NWEEPCNNGSEILAYTIDLGDTSITVGN----TTMHVMKDLLPETTYRIRIQAINEIGAG 944
               EP    ++  A  I   D  IT+ N    +T+ ++     +T   I I+A+N  G  
Sbjct: 7219 GKPEPKITWTK--ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRA 7275

Query: 945  PFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDR 1000
                 +    +P P  P   +      +S  L W     D  SK         T  + +R
Sbjct: 7276 TAVVEVNVLDKPGP--PAAFDITDVTNESCLLTWNPPRDDGGSK--------ITNYVVER 7325

Query: 1001 NKRFISIYRGPSHT-----YKVQRLTEFTCYSFRIQAASEAGEG------PFSETYTFST 1049
                  ++   S T     +K  +L     Y FR+ A +  G G      P +  Y F  
Sbjct: 7326 RATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDP 7385

Query: 1050 TKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--GE 1106
                PPT   P  + +  ++  + W       G P+  Y ++ L     ++ +  K   +
Sbjct: 7386 PG--PPTRLEP--SDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVK 7441

Query: 1107 EATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPS 1145
            + T+++ GL     YRFRV A        + L+G   PS
Sbjct: 7442 DTTYRVKGLTNKKKYRFRVLA--------ENLAGPGKPS 7472



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 195/897 (21%), Positives = 325/897 (36%), Gaps = 83/897 (9%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELEC--NLK 343
            +I+  +V+  W PP+        G S   +Y +   DK +     I+ +     C  ++ 
Sbjct: 8315 DIRKTSVLCKWEPPLD------DGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVT 8368

Query: 344  DLRPATDYHVRVYAMYNSVKGS--CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
             L    +Y  RV A      G    S+P+        P+ P  P +   + +S+ ++W  
Sbjct: 8369 KLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNE 8428

Query: 402  PIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
            P DNGS I  Y LE  E      S   +    + K   +  L   + Y FR+ A N  G 
Sbjct: 8429 PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALK-ANVDGLLEGLTYVFRVCAENAAGP 8487

Query: 460  SGYSQEVVCYTLGN--IPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ-ED 516
              +S      T  +   P  P  PR+     T + L+W  P      E++ Y ++ Q   
Sbjct: 8488 GKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVG 8547

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             N+     +   +    TVK ++    YK R++A N  G+  P E    T +  +  PP 
Sbjct: 8548 TNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQE-PPA 8606

Query: 577  RPL---VKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
              L   VKG +          P    G     K   +  +G  + ++  +   G+ +E  
Sbjct: 8607 VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTK-EEGELDKDRVVIDNVGTKSEL- 8664

Query: 634  FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI--APGQC--RPPRVLGRPKHKEVH 689
               +    L K     + T  +S C        + +   PG      P V  R   K   
Sbjct: 8665 ---IIKDALRKDHGRYVITATNS-CGSKFAAARVEVFDVPGPVLDLKPVVTNR---KMCL 8717

Query: 690  LEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP----ELECTVGNLLPGTVYRFRVRA 745
            L W  P  + G E++ + +E    +D     +  P      +C +  LL G  Y+FRV A
Sbjct: 8718 LNWSDPEDDGGSEITGFIIER---KDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIA 8774

Query: 746  LNDGGYGPYSDVSEITTA--AGPPGQCKAPCISCTPDGCVLVGWESPDSS-GADISEYRL 802
             N  G GP  ++  I      GPP   +    +      + + W+ P S+ G+ I  Y +
Sbjct: 8775 KNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYII 8834

Query: 803  E-WGEDEESLELIYHG--TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPA 858
            E    D+   E +       T F + +L     Y  R++A N+ G + P   L +     
Sbjct: 8835 EKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDD 8894

Query: 859  SAPDPV--------STLCVLEEEPLDAYPDSPSACL-VLNW---EEPCNNGSEILAYTID 906
              P  +         T+ V   EP+    D     +  + W   E      ++ L  T +
Sbjct: 8895 EVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKE 8954

Query: 907  LGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLEC 966
              + S +   T + + K  + E      + A N +G+   +  ++   RP P  P  L  
Sbjct: 8955 --EVSRSEAKTELSIPK-AVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSP--PRNLAV 9009

Query: 967  AAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFIS----IYRGPSHTYKVQRLTE 1022
                 +S  L W D+      +E   Y +   D +++               Y + +L  
Sbjct: 9010 TDIKAESCYLTW-DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9068

Query: 1023 FTCYSFRIQAASEAG--EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080
               Y FR++A ++ G  +   S+         +P     P+V      S  + W      
Sbjct: 9069 NGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDN 9128

Query: 1081 KGDPV-NYILQ---------VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
             G P+  Y L+           V R    K   KG E  F +  L     Y+FR  A
Sbjct: 9129 GGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVE--FNVPRLLEGVKYQFRAMA 9183



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 143/644 (22%), Positives = 251/644 (38%), Gaps = 65/644 (10%)

Query: 527  TGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
            T E  +  +   K+  + ++++   N  GK+   E  +     D PGP  R L       
Sbjct: 6551 TAEQTSFRILEAKKGDKGRYKIVLQNKHGKA---EGFINLKVIDVPGP-VRNLEVTETFD 6606

Query: 587  HGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHL-KPGTLYK 644
               S+ W+ P  +GGS+I+ Y++E  D   +   W +A     + E+T T L K G  Y 
Sbjct: 6607 GEVSLAWEEPLTDGGSKIIGYVVERRD--IKRKTWVLATDRAESCEFTVTGLQKGGVEYL 6664

Query: 645  LRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPR--VLGRPKHKEVHLEWDVPASES 699
             R      + TG   +    +  R+    PG   PP    +       V L W+ P  + 
Sbjct: 6665 FRVSARNRVGTGEPVETDNPVEARSKYDVPG---PPLNVTITDVNRFGVSLTWEPPEYDG 6721

Query: 700  GCEVSEYSVEMTEPEDV---ASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSD 756
            G E++ Y +E+ +   +    +      +L  TV +++ G  Y FRVRA N  G G  S 
Sbjct: 6722 GAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSA 6781

Query: 757  VSEITTAAGPPGQCKAPCISCTPD---GCVLVGWESP-DSSGADISEY---RLEWGEDEE 809
             +     A P  +   P    + D     V + WE P    G+ I  Y   R E G+D  
Sbjct: 6782 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 6841

Query: 810  ---SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASA-PDPVS 865
               +++L+    +  +++  L    +Y  R+ A N+AG    SE++   T   A  +P  
Sbjct: 6842 IRCNMKLV---PELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTM 6898

Query: 866  TLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDL 925
             L    ++ L+    +P   LV +   P    +    +   + +T   V   T+    +L
Sbjct: 6899 DLSAF-KDGLEVIVPNPITILVPSTGYP--RPTATWCFGDKVLETGDRVKMKTLSAYAEL 6955

Query: 926  L-------PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW 978
            +        +  Y ++++   +  +G     + A+    P  P  L+       S+ L W
Sbjct: 6956 VISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR----PSAPKELKFGDITKDSVHLTW 7011

Query: 979  ------GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
                  G S    +  E    + +   +   F++        + V  L +   Y F++ A
Sbjct: 7012 EPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVT-----DLEFTVPDLVQGKEYLFKVCA 7066

Query: 1033 ASEAGEGP---FSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
             ++ G G      E    ST  +VP   +  +      NS  + W+   +  G  +   +
Sbjct: 7067 RNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYI 7126

Query: 1090 QVLVGRESEYKQVYKGE---EATFQISGLQTNTDYRFRVCACRR 1130
                 R S+ K V  GE   E   +++GL+    Y +RV A  R
Sbjct: 7127 VERCPRGSD-KWVACGEPVAETKMEVTGLEEGKWYAYRVKALNR 7169



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 66/238 (27%), Positives = 107/238 (44%), Gaps = 17/238 (7%)

Query: 535   VKNLKRSTQY-KFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW 593
             +KN++R T   K+++  SN  G     + ++     D+P  PT P+V   +  +   + W
Sbjct: 24191 MKNVQRKTHAGKYKVQLSNVFGTV---DAILDVEIQDKPDKPTGPIVIEALLKNSAVISW 24247

Query: 594   DPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG-SATEYTFTHLKPGTLYKLRACCIST 652
              PP D+GGS I  Y++E  +   E  +W++  S  S T     +L     Y  R    +T
Sbjct: 24248 KPPADDGGSWITNYVVEKCEA-KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNT 24306

Query: 653   GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVH-----LEWDVPASESGCEVSEYS 707
              G    S+ L V ++ I       P   G+P    V      + W  PAS+ G ++  Y 
Sbjct: 24307 FG---ISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYY 24363

Query: 708   VEMTEPED---VASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 762
             +E  E +    ++       E   +V NL+ G  Y FRV+  N GG   +S++SE  T
Sbjct: 24364 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT 24421



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 171/823 (20%), Positives = 290/823 (35%), Gaps = 78/823 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG--EELE 339
             P+V +    ++ L+W  P+      + G +    Y + + +K  D  Y++  +      E
Sbjct: 22851 PRVVDTTKHSISLAWTKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 22904

Query: 340   CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP-KLAHRSKSSLTLQ 398
               + DL+    Y  RV A+  +VKG      S            P  +LA   K ++T++
Sbjct: 22905 FTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIR 22962

Query: 399   WKAPIDNGSKITNY---LLEWDEGKRNSGFRQCFFGSQKHCKLT--KLCPAMGYTFRLAA 453
               A +     ++     ++ W +   +   R     ++ +  L   K+       + + A
Sbjct: 22963 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 23022

Query: 454   RNDIGTSGYSQEVVCY-TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLE 512
              N  G    +  V  Y T G  P +    ++       VT+ W  P       V  Y +E
Sbjct: 23023 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWEIPTIDGGAPVNNYIVE 23078

Query: 513   IQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP 572
              +E                   +  L   T Y FR+   N  G   P E        + P
Sbjct: 23079 KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVP 23138

Query: 573   GPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEY 632
               P + L    VT    ++ W+ P  +GGS +  Y+LE     +E     V    +  E+
Sbjct: 23139 LVPAK-LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 23197

Query: 633   TFTHLKPGTLYKLRACCISTGGHSQCSE---SLPVRTLSIAPG---QCRPPRVL----GR 682
             T T L  G  Y  R    +  G S+  E   ++ V+ L + P       P + +    GR
Sbjct: 23198 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGR 23257

Query: 683   PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFR 742
             P    + +    P + S         ++ E E V  E  H    + T+          + 
Sbjct: 23258 PVELVIPIAGRPPPAASWFFAGS---KLRESERVTVET-HTKVAKLTIRETTIRDTGEYT 23313

Query: 743   VRALNDGGYGPYSDVSEITTAAGPP-GQCKAPCISCTPDGCVLVGWESPD-SSGADISEY 800
             +   N  G    +    I    GPP G  K   I  T    + + WE P+   GA +S Y
Sbjct: 23314 LELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDAT---SITISWEPPELDGGAPLSGY 23370

Query: 801   RLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY--SELVLCQT 856
              +E  +      L +    T + F+   L    +Y  R+ A N+ G G Y  SE++ C++
Sbjct: 23371 VVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS 23430

Query: 857   PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYTID----LGDTS 911
                 P P  TL +          D     + L W  P  + GS++  Y ++      D  
Sbjct: 23431 SIRIPGPPETLQIF---------DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRW 23481

Query: 912   ITVGNT----TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR------PLPPLP 961
             + V       T +    L     Y  R+ AIN  G+G  S+  K          P  P  
Sbjct: 23482 VRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQN 23541

Query: 962   PRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLT 1021
             PR+        SL     +    +     ++   +++       +        Y +  L 
Sbjct: 23542 PRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLP 23601

Query: 1022  EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQ 1064
             +   Y FR+ A +  G G  +E         VP T+K   + +
Sbjct: 23602 QGAEYRFRVLACNAGGPGEPAE---------VPGTVKVTEMLE 23635



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 195/894 (21%), Positives = 321/894 (35%), Gaps = 81/894 (9%)

Query: 282   PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
             P+V ++   +V LSW+ P        +G       E +     R  K +I  +       
Sbjct: 23839 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERK-ETSTDKWVRHNKTQITTT----MYT 23893

Query: 342   LKDLRPATDYHVRVYAMYN---SVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ 398
             +  L P  +Y  R+ A  +   S     SEPV        P  P   ++   SK S+TLQ
Sbjct: 23894 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 23953

Query: 399   WKAP-IDNGSKITNYLLEW----DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
             W+ P  D G +I  Y +E+    D   + S   +      K   +  L  A  Y FR+ A
Sbjct: 23954 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFA 24010

Query: 454   RNDIGTSGYSQEVVCY----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
              N+ G S   +  +      T G  P +    + V   +        +  G    ++  Y
Sbjct: 24011 ENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWY 24070

Query: 510   TLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
                 +E      +     G   T TV   ++  +  +   A+N  G+   S  L+   +P
Sbjct: 24071 RFG-KELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP 24129

Query: 570   D-RPGPPTRPLVKGPVTS----HGFSVKWDPPKDNG--GSEILKYLLEITDGNSEANQWE 622
                PG P +    G V S    H   +    P      G ++L+    IT  N+E     
Sbjct: 24130 QFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEH---- 24185

Query: 623   VAYSGSATEYTFTHLKPGTLY------KLRACCISTGGHSQCSESLPVRTLSIAPGQCRP 676
                        +THL    +       K +    +  G       + ++     P +   
Sbjct: 24186 -----------YTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD---KPDKPTG 24231

Query: 677   PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELE---CTVGNL 733
             P V+         + W  PA + G  ++ Y VE  E ++ A        +    C + NL
Sbjct: 24232 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 24291

Query: 734   LPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---PGQCKAPCISC-TPDGCVLVGWES 789
                  Y FRV A N  G     +VS +     P   PG    P I+  T D CV V W+ 
Sbjct: 24292 TENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCV-VAWKP 24350

Query: 790   PDS-SGADISEYRLEWGEDEESLELIYHGTDTR---FEIRDLLPAAQYCCRLQAFNQAGA 845
             P S  GA I  Y LE  E +++  +     + R   F +++L+   +Y  R++  N  G 
Sbjct: 24351 PASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGE 24410

Query: 846   GPYSELVLCQTPASAPDPVSTLCVLEE-EPLDAYPDSPS--ACLVLNWEEPC----NNGS 898
               +SE+    TP S   P+      EE   L+    S +   C V    +P       G 
Sbjct: 24411 SEWSEISEPITPKS-DVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGK 24469

Query: 899   EILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP 958
             EI+A  +         G   + ++  +  +     +++A N+ G+   +  ++ +     
Sbjct: 24470 EIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKI 24528

Query: 959   PLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQ----LEDRNKRFISIYRGPSHT 1014
              LP  LE   A   +L+ +            D V T Q    L D N  +  I      +
Sbjct: 24529 HLPKTLEGMGA-VHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS 24587

Query: 1015  YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
                    E     F +  A     G   +T        VP   +  +V+ +  +S  + W
Sbjct: 24588 LVFPNGVERKDAGFYVVCAKNR-FGIDQKTVELDVA-DVPDPPRGVKVSDVSRDSVNLTW 24645

Query: 1075  ETVPSMKGDPV-NYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                 S  G  + NYI++        + +V +  E  + +  L   T Y+FRV A
Sbjct: 24646 TEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIA 24699



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 141/629 (22%), Positives = 239/629 (37%), Gaps = 64/629 (10%)

Query: 446   GYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITW--VTLQWSKPEGCSP 503
             G  + L A N  G+  +   V      + P  P  P  V  G+T    +L WS P     
Sbjct: 17196 GGQYILRASNVAGSKSFPVNVKVL---DRPGPPEGPVQV-TGVTSEKCSLTWSPPLQDGG 17251

Query: 504   EEVITYTLEIQEDENDNLFHPKYTGEDLTCTVK--NLKRSTQYKFRLTASNTEGKSCPSE 561
              ++  Y +E  + E   L       E +T ++K   L    +Y FR+ A N  G   P E
Sbjct: 17252 SDISHYVVE--KRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLE 17309

Query: 562   VL-VCTTSPD-RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEAN 619
                V   +P   PGPP + L    +     +V W+ P  +GGSEI+ Y++E  D +    
Sbjct: 17310 SAPVLMKNPFVLPGPP-KSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI-- 17366

Query: 620   QWEVAYSGSATEYTF--THLKPGTLYKLRACCISTGGHSQCSESLPVRTLS---IAPGQC 674
             +W        T+     T L     Y+ R    +  G  + S +            PG  
Sbjct: 17367 RWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPP 17426

Query: 675   RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPE-LECT---V 730
                 ++   K+  + L W  P  + G E+  Y VE+ + ++   ++      L  T   +
Sbjct: 17427 TNAHIVDTTKNS-ITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEI 17485

Query: 731   GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD---GCVLVGW 787
               L     Y+ RV ALN  G G   + + +     P  + +AP +    +   G V+   
Sbjct: 17486 SKLTEHQEYKIRVCALNKVGLG---EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAG 17542

Query: 788   ESP----DSSGADISE--YRLEWGE--DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA 839
              S        G    E  +  E GE  D+  +E   + T    +  D   A +Y  +L+ 
Sbjct: 17543 GSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLEN 17602

Query: 840   FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC-NNGS 898
                  +G  S  V  +     P P   L V E     A+         L WE P  + G+
Sbjct: 17603 ----SSGSKSAFVTVKV-LDTPGPPQNLAVKEVRKDSAF---------LVWEPPIIDGGA 17648

Query: 899   EILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIK 951
             ++  Y ID  +++        +  + T   +++L     Y  R+ A NE G G   + + 
Sbjct: 17649 KVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVD 17708

Query: 952   AKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR-NKRFISIYR 1009
             A     PP PP ++        S  L W +       +  + Y ++++ +  +++  +  
Sbjct: 17709 AVKAAEPPSPPGKVTLTDVSQTSASLMW-EKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE 17767

Query: 1010  GPSHTYKVQRLTEFTCYSFRIQAASEAGE 1038
                    V  L+    Y FR++A +E G+
Sbjct: 17768 SKVCNAVVTGLSSGQEYQFRVKAYNEKGK 17796



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 38/292 (13%)

Query: 888  LNWEEPCNNG-SEILAYTIDLGDTSITVGNTTMHVMKDLLPE------------TTYRIR 934
            L WEEP  +G S+I+ Y ++  D    +   T  +  D                  Y  R
Sbjct: 6611 LAWEEPLTDGGSKIIGYVVERRD----IKRKTWVLATDRAESCEFTVTGLQKGGVEYLFR 6666

Query: 935  IQAINEIGAGPFSQF---IKAKTRPLPPLPP-RLECAAAGPQSLKLKWGDSNSKTHAAED 990
            + A N +G G   +    ++A+++   P PP  +         + L W +       AE 
Sbjct: 6667 VSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTW-EPPEYDGGAEI 6725

Query: 991  IVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG------PF 1041
              Y ++L D+           R    +  V  + E   YSFR++A +  G G      PF
Sbjct: 6726 TNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPF 6785

Query: 1042 SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLV-GRESEY 1099
             +        S P  + +   TQ   +S ++ WE      G P+  YI++    G+++  
Sbjct: 6786 VKVADPIERPSPPVNLTSSDQTQ---SSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWI 6842

Query: 1100 KQVYK-GEEATFQISGLQTNTDYRFRVCACRRC-LDTSQELSGAFSPSAAFV 1149
            +   K   E T++++GL+    Y +RV A  +  +    E+ G  +   AFV
Sbjct: 6843 RCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFV 6894



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 28/75 (37%), Positives = 36/75 (48%), Gaps = 1/75 (1%)

Query: 688   VHLEWDVPASESGCEVSEYSVE-MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRAL 746
             V+L W  PAS+ G +++ Y VE      +    V    E   TV NL   T Y+FRV A 
Sbjct: 24641 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24700

Query: 747   NDGGYGPYSDVSEIT 761
             N  G    S+ SE T
Sbjct: 24701 NKFGLSKPSEPSEPT 24715



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 3/91 (3%)

Query: 570   DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             D P PP R +    V+    ++ W  P  +GGS+I  Y++E     + A +W        
Sbjct: 24623 DVPDPP-RGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE--KCATTAERWLRVGQARE 24679

Query: 630   TEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             T YT  +L   T Y+ R    +  G S+ SE
Sbjct: 24680 TRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24710



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 379   PECPFPPKLAHRSKSSLTLQWKAPI-DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
             P+ P   K++  S+ S+ L W  P  D GSKITNY++   E    +  R    G  +  +
Sbjct: 24625 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIV---EKCATTAERWLRVGQARETR 24681

Query: 438   LT--KLCPAMGYTFRLAARNDIGTSGYSQ 464
              T   L     Y FR+ A N  G S  S+
Sbjct: 24682 YTVINLFGKTSYQFRVIAENKFGLSKPSE 24710



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 1/101 (0%)

Query: 461   GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
             G  Q+ V   + ++P  P   ++       V L W++P      ++  Y +E      + 
Sbjct: 24611 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24670

Query: 521   LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
                     E    TV NL   T Y+FR+ A N  G S PSE
Sbjct: 24671 WLRVGQARET-RYTVINLFGKTSYQFRVIAENKFGLSKPSE 24710


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  149 bits (376), Expect = 2e-35
 Identities = 172/724 (23%), Positives = 286/724 (39%), Gaps = 56/724 (7%)

Query: 284  VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE-VALSDKGRDGKYKIIYSGEELECNL 342
            V+   A +V L+W           SG S P +Y  +     G +G ++ +        ++
Sbjct: 327  VTETTATSVTLTW----------DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376

Query: 343  KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR--SKSSLTLQWK 400
              L P ++Y  RV A+ +  +G  SE V   T   AP  P P ++  R  S S++ +QW+
Sbjct: 377  GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQWE 435

Query: 401  APIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
             P +    +  Y + +    R   + + +    +     +  L P + Y+ R+ A   +G
Sbjct: 436  PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 495

Query: 459  TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEN 518
                S  +   T   +P  P+  +      T + L W  P     E +I Y L     E+
Sbjct: 496  DGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAED 552

Query: 519  DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP 578
            ++  H        + T+++LK  T Y+F+L A +  G    +  +   T+   P  P + 
Sbjct: 553  EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612

Query: 579  LVKGPVTSHGFSVKW-DPPKDNGGSEILKYLL--EITDGNSEANQWEVAYSGSATEYTFT 635
            ++   + S    V W  PP D+    I +Y +  E  DG           S   + +   
Sbjct: 613  VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 672

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR-VLGRPKHKE-VHLEWD 693
             L+  T Y++     +  G    S  + VRT    P    PPR V   P +   VH+ W 
Sbjct: 673  GLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG--PPRKVEVEPLNSTAVHVYWK 730

Query: 694  VPASES------GCEVSEYSVEMTEPED--VASEVYHGPELECTVGNLLPGTVYRFRVRA 745
            +P          G +V+   +E  EP    +  +V      E T+  L P T Y   V A
Sbjct: 731  LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAA 790

Query: 746  LNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWG 805
                G G  S    +TT    PG+     IS T     L+ W  P     ++  YRL++ 
Sbjct: 791  YTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYC 849

Query: 806  EDEESLE--LIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDP 863
              +E+    + +   D  F +  L     Y  RL A N+AG G   E  + +TP   P  
Sbjct: 850  RADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI-RTPEDLPSG 908

Query: 864  VSTLCVLEEEPLDAYPDS-PSACLVLNWEEP--CNNGSEILAYTIDLGDTSI-----TVG 915
                      P + +     ++   L W+ P        I++YT+   D +       + 
Sbjct: 909  F---------PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT 959

Query: 916  NTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL-PPRLECAAAGPQSL 974
              T   +  L P+TTY I+++A    G+GP S  I+++T P+  +       AAA   S+
Sbjct: 960  TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSV 1019

Query: 975  KLKW 978
             L W
Sbjct: 1020 LLSW 1023



 Score =  125 bits (314), Expect = 2e-28
 Identities = 167/719 (23%), Positives = 275/719 (38%), Gaps = 56/719 (7%)

Query: 457  IGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
            I + G  +     T+  +P+ P    +     T VTL W   +  + E V  Y ++ +  
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTW---DSGNSEPVTYYGIQYRAA 357

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
              +  F           ++  L   ++Y FR+ A N+ G+  PSE +   T    P  P 
Sbjct: 358  GTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPP 417

Query: 577  RPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTH 636
            R +    +++    V+W+PP++  G      +    D     N W    + +    T   
Sbjct: 418  RRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGS 477

Query: 637  LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR-PKHKEVHLEWDVP 695
            L PG  Y LR    +  G    S ++ V+T    P Q  P            + L W +P
Sbjct: 478  LLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSWLLP 535

Query: 696  ASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
              E    + E      E ED   +V   P    T+ +L P T+YRF++ A +D G G ++
Sbjct: 536  PQER-IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 756  DVSEITTAAGPPG--QCKAPCISCTPDGCVLVGWESP--DSSGADISEYRL--EWGEDEE 809
               E  TA   P     K  C+S      V V W  P  DS    I++Y +  E  + E+
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVS-MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 810  SLELIYHGTDTRFEIRDLLPA---AQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
                +  G        DL+      +Y   ++A    G GP S  VL +T    P     
Sbjct: 654  RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713

Query: 867  LCVLEEEPLDAYPDSPSACLVLNWEEPCNN-------GSEILAYTIDLGD-------TSI 912
               +E EPL+      S  + + W+ P  +       G ++    ++ G+         +
Sbjct: 714  --KVEVEPLN------STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765

Query: 913  TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 972
             +       +  L PETTY + + A    G G  S+     T    P  P +  +     
Sbjct: 766  MLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN 825

Query: 973  SLKLKWGDSNSKTHAAEDIVYTLQ---LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
            +  L+W     K    E + Y LQ    ++     I   +   H + V  L + T Y FR
Sbjct: 826  TALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTGLHKGTTYIFR 882

Query: 1030 IQAASEAGEGPFSETYTFSTTKSVPPTI-KAPRVTQLEGNSCEILWETVPSMKGDPVNYI 1088
            + A + AG G   E     T + +P    +   VT L  ++ E+ W+  P +       I
Sbjct: 883  LAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDP-PVLAERNGRII 940

Query: 1089 LQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPS 1145
               +V R+   +Q  +    +  F ++GL+ +T Y  +V A       + + SG  SPS
Sbjct: 941  SYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRA------WTSKGSGPLSPS 993



 Score =  123 bits (308), Expect = 1e-27
 Identities = 186/798 (23%), Positives = 285/798 (35%), Gaps = 81/798 (10%)

Query: 368  EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
            E  +  T    P+ P    +   + +S+TL W +   N   +T Y +++        F++
Sbjct: 308  EATAQVTVKALPKPPIDLVVTETTATSVTLTWDS--GNSEPVTYYGIQYRAAGTEGPFQE 365

Query: 428  CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAG 487
                +     +  L P   Y FR+ A N IG    S+ V   T    P  P  PR V+A 
Sbjct: 366  VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP--PRRVQAR 423

Query: 488  I---TWVTLQWSKPEGCSPEEVIT-YTLEIQEDEN--DNLFHPKYTGEDLTCTVKNLKRS 541
            +   + + +QW  PE   P  ++  Y +    D     N +H   T   L  TV +L   
Sbjct: 424  MLSASTMLVQWEPPE--EPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPG 481

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHG-FSVKWD-PPKDN 599
              Y  R+ A    G   PS  +   T    P  P     +  V S     + W  PP++ 
Sbjct: 482  ITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD--FQAEVESDTRIQLSWLLPPQER 539

Query: 600  GGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
                I+ Y L       E  Q +V +  +++ YT   LKP TLY+ +    S  G    +
Sbjct: 540  ----IIMYELVYWAAEDEDQQHKVTFDPTSS-YTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 660  ESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASES-GCEVSEYSV--EMTEPEDV 716
             ++  RT    P       +        V + W  P ++S    +++YSV  E  + ED 
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDR 654

Query: 717  ASEVYHGPELECTVGNLL---PGTVYRFRVRALNDGGYGPYSDVSEITT----AAGPPGQ 769
               V  G   E +  +L+     T YR  VRA  D G GP S    + T     +GPP +
Sbjct: 655  GRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRK 714

Query: 770  CKAPCISCTPDGCVLVGWESPDSS-------GADISEYRLEWGEDE--ESLELIYHGTDT 820
             +   ++ T    V V W+ P  S       G  ++  RLE GE      ++ +      
Sbjct: 715  VEVEPLNST---AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ 771

Query: 821  RFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPD 880
               I  L P   Y   + A+   G G  S+          P  V+T   +   P      
Sbjct: 772  ETTISGLTPETTYSVTVAAYTTKGDGARSK----------PKIVTTTGAVPGRPTMMIST 821

Query: 881  SPSACLVLNWEEPCNNGSEILAYTI------DLGDTSITVGNTTMH-VMKDLLPETTYRI 933
            +     +L W  P     E+L Y +      +    +I  G    H  +  L   TTY  
Sbjct: 822  TAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIF 881

Query: 934  RIQAINEIGAGP-FSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV 992
            R+ A N  G G  F + I+         P  L        + +L W            I 
Sbjct: 882  RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS 941

Query: 993  YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS 1052
            YT+   D N +           + +  L   T Y  +++A +  G GP S +    T   
Sbjct: 942  YTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPV 1001

Query: 1053 VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQ- 1111
                 K  RV      S  + WE   S K                 +K +Y G+      
Sbjct: 1002 EQVFAKNFRVAAAMKTSVLLSWEVPDSYKS-------------AVPFKILYNGQSVEVDG 1048

Query: 1112 ------ISGLQTNTDYRF 1123
                  I+ LQ NT+Y F
Sbjct: 1049 HSMRKLIADLQPNTEYSF 1066


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  148 bits (373), Expect = 3e-35
 Identities = 171/710 (24%), Positives = 285/710 (40%), Gaps = 65/710 (9%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVAL-SDKGRDGKYKIIYSGEELEC 340
            P V+   A ++ L+W           SG   P SY +     K  +  YK I        
Sbjct: 329  PVVTESTATSITLTW----------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 378

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPE-CPFPPKLAHRSKSSLTLQW 399
            ++  L P +DY  RV A+ N  +G  SEPV   T   AP   P   +    S +++ +QW
Sbjct: 379  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 400  KAPIDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
            K P +   +I  Y + +  D  +  + + +      +   +  L P   Y+ ++ A   I
Sbjct: 439  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498

Query: 458  GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDE 517
            G    S ++   T   +P  P   +      T + L W+ P     + +  Y L  ++ E
Sbjct: 499  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS---DTIANYELVYKDGE 555

Query: 518  NDNLFHPKYTGEDLTC-TVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
            +      + T E  T   ++ LK ++ Y FRL A + +G    +  +   T   +P  P 
Sbjct: 556  HGE--EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP 613

Query: 577  RPLVKGPVTSHGFSVKWDPP---KDNGGSEILKYLLEIT--DGNSEANQWEVAYSGSATE 631
            + +     +S    V W PP   K NG   I +Y ++ T  DG  +     +      T+
Sbjct: 614  QDISCTSPSSTSILVSWQPPPVEKQNG--IITEYSIKYTAVDGEDDKPHEILGIPSDTTK 671

Query: 632  YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVH 689
            Y    L+  T Y++     +  G    S S+ +RT    P    PPR +         V 
Sbjct: 672  YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG--PPRKVEVEAVNSTSVK 729

Query: 690  LEWDVPASES------GCEVSEYSVEMTEP--EDVASEVYHGPELECTVGNLLPGTVYRF 741
            + W  P          G +V    +E  EP  + +  +V      +  +  L P T Y  
Sbjct: 730  VSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSL 789

Query: 742  RVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYR 801
             V A    G G  S    ++T    PG+ +   I+ T     L+ W  P  +   +  YR
Sbjct: 790  TVTAYTTKGDGARSKPKLVSTTGAVPGKPRL-VINHTQMNTALIQWHPPVDTFGPLQGYR 848

Query: 802  LEWG-EDEESLELI-YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPAS 859
            L++G +D E L  + +   +  F   D+   A Y  RL A N+ G G   E+V      S
Sbjct: 849  LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMV---KEIS 903

Query: 860  APDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP--CNNGSEILAYTIDLGDTSITV-- 914
             P+ V T       P + + +  ++  V L+W+ P        I  YT+   D +I +  
Sbjct: 904  IPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 958

Query: 915  -------GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPL 957
                    +TTM  +  L P+TTY ++++A    G GP+S  ++ +T P+
Sbjct: 959  MEQLIVPADTTM-TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1007



 Score =  123 bits (309), Expect = 9e-28
 Identities = 175/774 (22%), Positives = 287/774 (37%), Gaps = 74/774 (9%)

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
            L D+R + +Y     +    +     E ++  T    P+ P  P +   + +S+TL W +
Sbjct: 291  LNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTWDS 345

Query: 402  PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
               N   ++ Y+++         +++    +     +  L P   Y FR+ A N+IG   
Sbjct: 346  --GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGP 403

Query: 462  YSQEVVCYTLGNIPQMPSAPRLVRAGI---TWVTLQWSKPE---GCSPEEVITYTLEIQE 515
             S+ V+  T    P   SAPR V+A +   T + +QW +PE   G      + YT++  +
Sbjct: 404  PSEPVLTQTSEQAPS--SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              N+ + H     +    T+ NL     Y  ++ A  + G    S  +   T    PG P
Sbjct: 462  HVNNWMKHN--VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 576  TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 635
                 + P +     + W PP+ +    I  Y L   DG     Q      G  T Y   
Sbjct: 520  LNFKAE-PESETSILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPG--TSYRLQ 573

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVHLEWD 693
             LKP +LY  R    S  G    +  +  RT+   P    PP+ +    P    + + W 
Sbjct: 574  GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQ 631

Query: 694  VPASES-GCEVSEYSVEMTE---PEDVASEVYHGPE--LECTVGNLLPGTVYRFRVRALN 747
             P  E     ++EYS++ T     +D   E+   P    +  +  L   T YR  V A  
Sbjct: 632  PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 691

Query: 748  DGGYGPYSDVSEITT----AAGPPGQCKAPCISCTPDGCVLVGWESPDSS-------GAD 796
            D G GP S    I T     +GPP + +   ++ T    V V W SP  +       G  
Sbjct: 692  DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS---VKVSWRSPVPNKQHGQIRGYQ 748

Query: 797  ISEYRLEWGED--EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLC 854
            +   R+E GE   +  L+ +         I  L P   Y   + A+   G G  S+    
Sbjct: 749  VHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSK---- 804

Query: 855  QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD----- 909
                  P  VST   +  +P      +     ++ W  P +    +  Y +  G      
Sbjct: 805  ------PKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEP 858

Query: 910  -TSITVGNTTMH-VMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP--LPP-LPPRL 964
             T++       H    D+    +Y  R+ A N++G G   + +K  + P  +P   P  L
Sbjct: 859  LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNL 916

Query: 965  ECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR---GPSHTYKVQRLT 1021
                    S++L W              YTL   D N   + + +       T  +  L 
Sbjct: 917  HSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLK 976

Query: 1022 EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWE 1075
              T Y  +++A +  G GP+S +  F T        K   V  +   S  + WE
Sbjct: 977  PDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWE 1030



 Score =  116 bits (291), Expect = 1e-25
 Identities = 169/758 (22%), Positives = 298/758 (39%), Gaps = 126/758 (16%)

Query: 457  IGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
            + T G  + +   T+  +P+ P  P +  +  T +TL W   +  +PE V  Y ++ +  
Sbjct: 305  MSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTW---DSGNPEPVSYYIIQHKPK 361

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             ++ L+           +V  L   + Y+FR+ A N  G+  PSE ++  TS   P    
Sbjct: 362  NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 421

Query: 577  RPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFT 635
            R +    ++S    V+W  P++  G +I  Y +  T D     N W       +   T  
Sbjct: 422  RDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDV 694
            +L P   Y ++    ++ G    S  + V T +  PGQ  P      P+ +  + L W  
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTP 538

Query: 695  PASESGCEVSEYSVEMTEPEDVASEVYHGPELECTV--------GNLLPGTVYRFRVRAL 746
            P S++   ++ Y +   + E       HG E   T+          L P ++Y FR+ A 
Sbjct: 539  PRSDT---IANYELVYKDGE-------HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAAR 588

Query: 747  NDGGYG-PYSDVSEITTAAGPPGQCKAPCISCTPDG--CVLVGWESP--DSSGADISEYR 801
            +  G G   +++S  T  + P        ISCT      +LV W+ P  +     I+EY 
Sbjct: 589  SPQGLGASTAEISARTMQSKP--SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYS 646

Query: 802  LEW----GEDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT 856
            +++    GED++  E++   +D T++ +  L    +Y   + A    G GP S  VL +T
Sbjct: 647  IKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRT 706

Query: 857  ----PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN-------GSEILAYTI 905
                P+  P  V    V             S  + ++W  P  N       G ++    +
Sbjct: 707  NEDVPSGPPRKVEVEAV------------NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRM 754

Query: 906  DLGD-------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP 958
            + G+         + + +    ++  L PET+Y + + A    G G  S+     T    
Sbjct: 755  ENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAV 814

Query: 959  PLPPRL----------------ECAAAGP-QSLKLKWGDSNSKTHAAEDIVYTLQLEDRN 1001
            P  PRL                     GP Q  +LK+G  + +       + TL+  ++ 
Sbjct: 815  PGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEP------LTTLEFSEKE 868

Query: 1002 KRFIS--IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKA 1059
              F +  I++G S             Y FR+ A ++ G G        S  + VP     
Sbjct: 869  DHFTATDIHKGAS-------------YVFRLSARNKVGFGE-EMVKEISIPEEVPTGF-- 912

Query: 1060 PRVTQLEG---NSCEILWETVPSMKGDPVNYILQ-VLVGRESE-----YKQVYKGEEATF 1110
            P+    EG    S ++ W+  P +  +    I +  L+ R+        +Q+    + T 
Sbjct: 913  PQNLHSEGTTSTSVQLSWQ--PPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTM 970

Query: 1111 QISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAF 1148
             ++GL+ +T Y  +V A       + +  G +SPS  F
Sbjct: 971  TLTGLKPDTTYDVKVRA------HTSKGPGPYSPSVQF 1002


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  146 bits (369), Expect = 1e-34
 Identities = 176/733 (24%), Positives = 290/733 (39%), Gaps = 65/733 (8%)

Query: 284  VSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYE-VALSDKGRDGKYKIIYSGEELECNL 342
            V+   A +V L+W           SG S P +Y  +     G +G ++ +        ++
Sbjct: 327  VTETTATSVTLTW----------DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI 376

Query: 343  KDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR--SKSSLTLQWK 400
              L P ++Y  RV A+ +  +G  SE V   T   AP  P P ++  R  S S++ +QW+
Sbjct: 377  GGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQWE 435

Query: 401  APIDNGSKITNYLLEWDEGKRN--SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
             P +    +  Y + +    R   + + +    +     +  L P + Y+ R+ A   +G
Sbjct: 436  PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 495

Query: 459  TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEN 518
                S  +   T   +P  P+  +      T + L W  P     E +I Y L     E+
Sbjct: 496  DGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAED 552

Query: 519  DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP 578
            ++  H        + T+++LK  T Y+F+L A +  G    +  +   T+   P  P + 
Sbjct: 553  EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612

Query: 579  LVKGPVTSHGFSVKW-DPPKDNGGSEILKYLL--EITDGNSEANQWEVAYSGSATEYTFT 635
            ++   + S    V W  PP D+    I +Y +  E  DG           S   + +   
Sbjct: 613  VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 672

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR-VLGRPKHKE-VHLEWD 693
             L+  T Y++     +  G    S  + VRT    P    PPR V   P +   VH+ W 
Sbjct: 673  GLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG--PPRKVEVEPLNSTAVHVYWK 730

Query: 694  VPASES------GCEVSEYSVEMTEP------EDVA-SEVYHGPE----LECTVGNLLPG 736
            +P          G +V+   +E  EP      +DV  +E    PE     E T+  L P 
Sbjct: 731  LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPE 790

Query: 737  TVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGAD 796
            T Y   V A    G G  S    +TT    PG+     IS T     L+ W  P     +
Sbjct: 791  TTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGE 849

Query: 797  ISEYRLEWGEDEESLE--LIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLC 854
            +  YRL++   +E+    + +   D  F +  L     Y  RL A N+AG G   E  + 
Sbjct: 850  LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI- 908

Query: 855  QTPASAPDPVSTLCVLEEEPLDAYPDS-PSACLVLNWEEP--CNNGSEILAYTIDLGDTS 911
            +TP   P            P + +     ++   L W+ P        I++YT+   D +
Sbjct: 909  RTPEDLPSGF---------PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDIN 959

Query: 912  I-----TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL-PPRLE 965
                   +   T   +  L P+TTY I+++A    G+GP S  I+++T P+  +      
Sbjct: 960  SQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFR 1019

Query: 966  CAAAGPQSLKLKW 978
             AAA   S+ L W
Sbjct: 1020 VAAAMKTSVLLSW 1032



 Score =  122 bits (305), Expect = 3e-27
 Identities = 189/808 (23%), Positives = 286/808 (35%), Gaps = 92/808 (11%)

Query: 368  EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
            E  +  T    P+ P    +   + +S+TL W +   N   +T Y +++        F++
Sbjct: 308  EATAQVTVKALPKPPIDLVVTETTATSVTLTWDS--GNSEPVTYYGIQYRAAGTEGPFQE 365

Query: 428  CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAG 487
                +     +  L P   Y FR+ A N IG    S+ V   T    P  P  PR V+A 
Sbjct: 366  VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP--PRRVQAR 423

Query: 488  I---TWVTLQWSKPEGCSPEEVIT-YTLEIQEDEN--DNLFHPKYTGEDLTCTVKNLKRS 541
            +   + + +QW  PE   P  ++  Y +    D     N +H   T   L  TV +L   
Sbjct: 424  MLSASTMLVQWEPPE--EPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPG 481

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHG-FSVKWD-PPKDN 599
              Y  R+ A    G   PS  +   T    P  P     +  V S     + W  PP++ 
Sbjct: 482  ITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD--FQAEVESDTRIQLSWLLPPQER 539

Query: 600  GGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCS 659
                I+ Y L       E  Q +V +  +++ YT   LKP TLY+ +    S  G    +
Sbjct: 540  ----IIMYELVYWAAEDEDQQHKVTFDPTSS-YTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 660  ESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASES-GCEVSEYSV--EMTEPEDV 716
             ++  RT    P       +        V + W  P ++S    +++YSV  E  + ED 
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDR 654

Query: 717  ASEVYHGPELECTVGNLL---PGTVYRFRVRALNDGGYGPYSDVSEITT----AAGPPGQ 769
               V  G   E +  +L+     T YR  VRA  D G GP S    + T     +GPP +
Sbjct: 655  GRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRK 714

Query: 770  CKAPCISCTPDGCVLVGWESPDSS-------GADISEYRLEWGEDEESLELIY------- 815
             +   ++ T    V V W+ P  S       G  ++  RLE GE    L +I        
Sbjct: 715  VEVEPLNST---AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR-GLPIIQDVMLAEA 770

Query: 816  -----HGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
                    D    I  L P   Y   + A+   G G  S+          P  V+T   +
Sbjct: 771  QWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSK----------PKIVTTTGAV 820

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI------DLGDTSITVGNTTMH-VMK 923
               P      +     +L W  P     E+L Y +      +    +I  G    H  + 
Sbjct: 821  PGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVT 880

Query: 924  DLLPETTYRIRIQAINEIGAGP-FSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSN 982
             L   TTY  R+ A N  G G  F + I+         P  L        + +L W    
Sbjct: 881  GLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPV 940

Query: 983  SKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFS 1042
                    I YT+   D N +           + +  L   T Y  +++A +  G GP S
Sbjct: 941  LAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLS 1000

Query: 1043 ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQV 1102
             +    T        K  RV      S  + WE   S K                 +K +
Sbjct: 1001 PSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKS-------------AVPFKIL 1047

Query: 1103 YKGEEATFQ-------ISGLQTNTDYRF 1123
            Y G+            I+ LQ NT+Y F
Sbjct: 1048 YNGQSVEVDGHSMRKLIADLQPNTEYSF 1075



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/728 (23%), Positives = 273/728 (37%), Gaps = 65/728 (8%)

Query: 457  IGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
            I + G  +     T+  +P+ P    +     T VTL W   +  + E V  Y ++ +  
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTW---DSGNSEPVTYYGIQYRAA 357

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
              +  F           ++  L   ++Y FR+ A N+ G+  PSE +   T    P  P 
Sbjct: 358  GTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPP 417

Query: 577  RPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTH 636
            R +    +++    V+W+PP++  G      +    D     N W    + +    T   
Sbjct: 418  RRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGS 477

Query: 637  LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR-PKHKEVHLEWDVP 695
            L PG  Y LR    +  G    S ++ V+T    P Q  P            + L W +P
Sbjct: 478  LLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSWLLP 535

Query: 696  ASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
              E    + E      E ED   +V   P    T+ +L P T+YRF++ A +D G G ++
Sbjct: 536  PQER-IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 756  DVSEITTAAGPPG--QCKAPCISCTPDGCVLVGWESP--DSSGADISEYRL--EWGEDEE 809
               E  TA   P     K  C+S      V V W  P  DS    I++Y +  E  + E+
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVS-MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 810  SLELIYHGTDTRFEIRDLLPA---AQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVST 866
                +  G        DL+      +Y   ++A    G GP S  VL +T    P     
Sbjct: 654  RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713

Query: 867  LCVLEEEPLDAYPDSPSACLVLNWE--EPCNNGSEILAYTID--------------LGDT 910
               +E EPL+      S  + + W+   P     +I  Y +               + D 
Sbjct: 714  --KVEVEPLN------STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765

Query: 911  SITVGNTTMHVMKD-------LLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPR 963
             +          +D       L PETTY + + A    G G  S+     T    P  P 
Sbjct: 766  MLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT 825

Query: 964  LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQ---LEDRNKRFISIYRGPSHTYKVQRL 1020
            +  +     +  L+W     K    E + Y LQ    ++     I   +   H + V  L
Sbjct: 826  MMISTTAMNTALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTGL 882

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTI-KAPRVTQLEGNSCEILWETVPS 1079
             + T Y FR+ A + AG G   E     T + +P    +   VT L  ++ E+ W+  P 
Sbjct: 883  HKGTTYIFRLAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDP-PV 940

Query: 1080 MKGDPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACRRCLDTSQE 1137
            +       I   +V R+   +Q  +    +  F ++GL+ +T Y  +V A       + +
Sbjct: 941  LAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRA------WTSK 994

Query: 1138 LSGAFSPS 1145
             SG  SPS
Sbjct: 995  GSGPLSPS 1002


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  145 bits (367), Expect = 2e-34
 Identities = 218/900 (24%), Positives = 342/900 (38%), Gaps = 107/900 (11%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK------IIYSG 335
            P      A +V+L+W  P      P+  +S    Y V   ++  D  +           G
Sbjct: 3971 PWAQATSAHSVLLNWTKPES----PNGIISH---YRVVYQERPDDPTFNSPTVHAFTVKG 4023

Query: 336  EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS-- 393
               + +L  L P T Y + V A  ++  G    P +      +        +  + ++  
Sbjct: 4024 TSHQAHLYGLEPFTTYRIGVVAANHA--GEILSPWTLIQTLESSPSGLRNFIVEQKENGR 4081

Query: 394  SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
            +L LQW  P+     I  Y +  D     SG  + F          +L P   YT  L A
Sbjct: 4082 ALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFL-------FRRLDPFTLYTLTLEA 4134

Query: 454  RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE----EVITY 509
                G + +S     +T    P    AP +     T V L WS+P   + +    EVI  
Sbjct: 4135 CTRAGCA-HSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRR 4193

Query: 510  TLE--------IQEDENDNLFHPKYTGEDLTCTVKN--LKRSTQYKFRLTASNTEGKSCP 559
              E        IQ DE   +   +Y  E  T    +  L+  TQ ++++   N+ G +C 
Sbjct: 4194 CFEGKAWGNQTIQADEK--IVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCS 4251

Query: 560  SEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
            S  +V T    P+   PP    V   +      + W PP+ + G  I  Y L+  +    
Sbjct: 4252 SWNVVRTLQAPPEGLSPPVISYVS--MNPQKLLISWIPPEQSNGI-IQSYRLQRNE---- 4304

Query: 618  ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQCR 675
               +  ++      YT   L P + Y       ++GG   CS S P  + TL  AP +  
Sbjct: 4305 -MLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGG---CSTSKPTSITTLEAAPSEVS 4360

Query: 676  PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
            PP  L      ++++ W  P  ++G ++++Y V     E +A     G  L   V +L P
Sbjct: 4361 PPD-LWAVSATQMNVCWSPPTVQNG-KITKYLVRYDNKESLA-----GQGLCLLVSHLQP 4413

Query: 736  GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             + Y F + A  +GG       S  T  A P     +P +  T    + + W+ P +   
Sbjct: 4414 YSQYNFSLVACTNGGCTASVSKSAWTMEALPENM-DSPTLQVTGSESIEITWKPPRNPNG 4472

Query: 796  DISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ 855
             I  Y L          ++Y G +TR+    L P  +Y   + A N  G G  S LV  +
Sbjct: 4473 QIRSYELR-----RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDR 4526

Query: 856  TPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD-----T 910
            T  SAP  +        EP       P   LV NW+ P     +I+ YT+ + +     T
Sbjct: 4527 TSPSAPSGM--------EPPKLQARGPQEILV-NWDPPVRTNGDIINYTLFIRELFERET 4577

Query: 911  SITVGNTT-------MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--- 960
             I   NTT        +++  L P   Y IRIQA   +G    S +   +T  + PL   
Sbjct: 4578 KIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQP 4636

Query: 961  PPRLEC--AAAGPQ-SLKLKWG---DSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
            PP LE   A  G Q ++ L W      N K    E     +  + R    + IY G S +
Sbjct: 4637 PPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTS 4696

Query: 1015 YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT-IKAPRVTQLEGNSCEIL 1073
            +    L  FT Y +++ A + AG+ P S  +T+  T   PP  ++AP    +      ++
Sbjct: 4697 FIDSELLPFTEYEYQVWAVNSAGKAPSS--WTWCRTGPAPPEGLRAPTFHVISSTQA-VV 4753

Query: 1074 WETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRV--CACRRC 1131
              + P      V+               + +G      + GLQ  T+Y   V  C C  C
Sbjct: 4754 NISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNC 4813



 Score =  126 bits (316), Expect = 1e-28
 Identities = 213/912 (23%), Positives = 345/912 (37%), Gaps = 127/912 (13%)

Query: 273  QDILSGIEKP---QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKY 329
            +D+  G+  P   ++ N++   +VL+W  P+  +         P  Y + L    R+G  
Sbjct: 3496 EDVPQGVSPPTWTKIDNLED-TIVLNWRKPIQSNG--------PIIYYILL----RNGIE 3542

Query: 330  KIIYSGEELECNLKD-LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLA 388
            +  + G  L  + K+ ++P  +Y  ++ A   +   + S+ V+ TT    PE   PP + 
Sbjct: 3543 R--FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQG-VPESILPPSIT 3599

Query: 389  HRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYT 448
              S  +L L W  P  +   I  Y +     +   G        ++   +T L P   Y+
Sbjct: 3600 ALSAVALHLSWSVPEKSNGVIKEYQIR----QVGKGLIHTDTTDRRQHTVTGLQPYTNYS 3655

Query: 449  FRLAARNDIGTSGYSQEVVCYTLGNIPQ-MPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
            F L A    G +  S+  +  TL   P+ +   PR +    T V L WS PE   P  ++
Sbjct: 3656 FTLTACTSAGCTS-SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPE--KPNGLV 3712

Query: 508  TYTLEIQEDENDNLFHPKYTG--EDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
            +   + Q   N NL    + G  E+   T KNL+ +++Y ++L      G S   + +V 
Sbjct: 3713 S---QYQLSRNGNLL---FLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQ 3766

Query: 566  T--TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
            T  ++P+   PP    V GP   +   V W PP        ++Y + + DG+     + V
Sbjct: 3767 TPMSTPEEIYPPYNITVIGP---YSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSV 3823

Query: 624  AYSGSATEYTFTHLKPGTLYKLR--ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
             +  S       +L P T Y++R  AC     G    S  + V+T   AP     P VL 
Sbjct: 3824 GHHQSTL---LENLTPFTQYEIRIQAC---QNGSCGVSSRMFVKTPEAAPMDLNSP-VLK 3876

Query: 682  RPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGPELECTVGNLL-PGT 737
                  + ++W  P   +G  ++ +        E E V      G       G+ L P T
Sbjct: 3877 ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFT 3936

Query: 738  VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
            +Y +RVRA N  G    S  S   T   PP    AP    T    VL+ W  P+S    I
Sbjct: 3937 LYEYRVRACNSKG-SVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGII 3995

Query: 798  SEYRLEWGE--DEESLE------LIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
            S YR+ + E  D+ +            GT  +  +  L P   Y   + A N AG    S
Sbjct: 3996 SHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILS 4054

Query: 850  ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
               L QT  S+P  +    V ++E            L+L W EP      I  Y I    
Sbjct: 4055 PWTLIQTLESSPSGLRNFIVEQKE--------NGRALLLQWSEPMRTNGVIKTYNIFSDG 4106

Query: 910  TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP----PLPPRLE 965
                 G     + + L P T Y + ++A    G         A + P P      PP  +
Sbjct: 4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC--------AHSAPQPLWTDEAPPDSQ 4158

Query: 966  CA----AAGPQSLKLKWGD-----------------------SNSKTHAAEDIVYTLQLE 998
             A    +    S++L W +                        N    A E IV+T    
Sbjct: 4159 LAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT 4218

Query: 999  DRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIK 1058
            +RN          +  Y    L  +T   ++I   + AG    S      T ++ P  + 
Sbjct: 4219 ERN----------TFMYNDTGLQPWTQCEYKIYTWNSAGH-TCSSWNVVRTLQAPPEGLS 4267

Query: 1059 APRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISG--LQ 1116
             P ++ +  N  ++L   +P    +  N I+Q    + +E    +  +  TF  +   L 
Sbjct: 4268 PPVISYVSMNPQKLLISWIPP---EQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELL 4324

Query: 1117 TNTDYRFRVCAC 1128
              + Y + + AC
Sbjct: 4325 PFSTYSYALQAC 4336



 Score =  123 bits (309), Expect = 9e-28
 Identities = 185/797 (23%), Positives = 306/797 (38%), Gaps = 78/797 (9%)

Query: 269  VKRVQDILSGIEKPQVS--NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRD 326
            V+ +Q    G+  P +S  ++  + +++SW PP               SY +  ++    
Sbjct: 4256 VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPP-------EQSNGIIQSYRLQRNEM--- 4305

Query: 327  GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCS--EPVSFTTHSCAPECPFP 384
              Y   +         ++L P + Y    YA+     G CS  +P S TT   AP    P
Sbjct: 4306 -LYPFSFDPVTFNYTDEELLPFSTYS---YALQACTSGGCSTSKPTSITTLEAAPSEVSP 4361

Query: 385  PKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
            P L   S + + + W  P     KIT YL+ +D  +  +G   C         ++ L P 
Sbjct: 4362 PDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLL-------VSHLQPY 4414

Query: 445  MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
              Y F L A  + G +  S     +T+  +P+   +P L   G   + + W  P   +P 
Sbjct: 4415 SQYNFSLVACTNGGCTA-SVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPR--NPN 4471

Query: 505  EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLV 564
              I  + E++ D         YTG +       L    +Y + +TASN++G    S ++ 
Sbjct: 4472 GQIR-SYELRRDGT-----IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVK 4524

Query: 565  CTTSPDRPG--PPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL---EITDGNSEAN 619
              TSP  P    P +   +GP       V WDPP    G +I+ Y L   E+ +  ++  
Sbjct: 4525 DRTSPSAPSGMEPPKLQARGP---QEILVNWDPPVRTNG-DIINYTLFIRELFERETKII 4580

Query: 620  QWEVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
                 ++    + Y    LKP   Y++R    +T G +  S+   ++T  IAP    PP 
Sbjct: 4581 HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQPPPH 4639

Query: 679  VLGRPK----HKEVHLEWDVPASESG----CEVSEYSVEMTEPEDVASEVYHGPELECTV 730
            +  +         V L W  P   +G     E+    +     +     +Y+G       
Sbjct: 4640 LEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699

Query: 731  GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP 790
              LLP T Y ++V A+N  G  P S  +   T   PP   +AP          +V   +P
Sbjct: 4700 SELLPFTEYEYQVWAVNSAGKAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAP 4758

Query: 791  DSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA---FNQAGAGP 847
                  +S YRL       +  ++  G  T+  +  L     Y   ++A   FN    GP
Sbjct: 4759 GKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGP 4818

Query: 848  YSELVLCQTPAS--APDPVSTLCVLEEEPLDAYPDSPSACL---VLNWEEPCNNGSEILA 902
             +EL     P S  +   + TL         + P  P+  +    L +   C   S  L 
Sbjct: 4819 TAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDS-ALP 4877

Query: 903  YTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG--AGPFSQFIKAKTRPLPPL 960
             T    +T  T G      +  L P TTY++R+ A NE+G  A  +  F   K  P    
Sbjct: 4878 CTPSQIETKYT-GLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRA 4936

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
            P  ++   +    + + W D+       ++ V T    D  +R   +Y G   T  + R 
Sbjct: 4937 PFSVD---SNLSVVCVNWSDTFLLNGQLKEYVLT----DGGRR---VYSGLDTTLYIPRT 4986

Query: 1021 TEFTCYSFRIQAASEAG 1037
             + T + F++   ++ G
Sbjct: 4987 ADKT-FFFQVICTTDEG 5002



 Score =  119 bits (298), Expect = 2e-26
 Identities = 196/881 (22%), Positives = 311/881 (35%), Gaps = 145/881 (16%)

Query: 333  YSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHR 390
            YSG   +   + L P T Y + + A     +  C  S P    T    P+    P +   
Sbjct: 4110 YSGLNRQFLFRRLDPFTLYTLTLEAC---TRAGCAHSAPQPLWTDEAPPDSQLAPTVHSV 4166

Query: 391  SKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFR 450
              +S+ L W  P++   KI  Y +           R+CF G     +  +    + +T  
Sbjct: 4167 KSTSVELSWSEPVNPNGKIIRYEV----------IRRCFEGKAWGNQTIQADEKIVFTEY 4216

Query: 451  LAARN-----DIGTSGYSQ-EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
               RN     D G   ++Q E   YT  +     S+  +VR      TLQ + PEG SP 
Sbjct: 4217 NTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVR------TLQ-APPEGLSPP 4269

Query: 505  EVITYTLEIQE--------------------DENDNLFHPKYTGEDLTCTVKNLKRSTQY 544
             +   ++  Q+                      N+ L+   +       T + L   + Y
Sbjct: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTY 4329

Query: 545  KFRLTASNTEGKSC--PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602
             + L A  + G S   P+ +     +P    PP        V++   +V W PP    G 
Sbjct: 4330 SYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDL----WAVSATQMNVCWSPPTVQNG- 4384

Query: 603  EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662
            +I KYL+   +  S A        G       +HL+P + Y       + GG +  S S 
Sbjct: 4385 KITKYLVRYDNKESLA--------GQGLCLLVSHLQPYSQYNFSLVACTNGGCT-ASVSK 4435

Query: 663  PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH 722
               T+   P     P  L     + + + W  P + +G ++  Y +         + VY 
Sbjct: 4436 SAWTMEALPENMDSP-TLQVTGSESIEITWKPPRNPNG-QIRSYELRRD-----GTIVYT 4488

Query: 723  GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC 782
            G E       L PG  Y + V A N  G G  S + +  T+   P   + P +       
Sbjct: 4489 GLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547

Query: 783  VLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTR-------FEIRDLLPAAQYCC 835
            +LV W+ P  +  DI  Y L   E  E    I H   T        + +  L P  +Y  
Sbjct: 4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEI 4607

Query: 836  RLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP---LDAYPDSPSACLVLNWEE 892
            R+QA    G    S+    QTP  AP       +++  P   +   P      + L W  
Sbjct: 4608 RIQACTTLGCAS-SDWTFIQTPEIAP-------LMQPPPHLEVQMAPGGFQPTVSLLWTG 4659

Query: 893  PCNNGSEILAYTI----------DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
            P     ++L Y +                I  G++T  +  +LLP T Y  ++ A+N  G
Sbjct: 4660 PLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAG 4719

Query: 943  AGPFSQFIKAKTRPLPPLPPR-------------LECAAAG-PQSLKLKWGDSNSKTHAA 988
              P S +   +T P PP   R             +  +A G P  +   +   +S  H A
Sbjct: 4720 KAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGA 4778

Query: 989  EDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASE---AGEGPFSETY 1045
            E +               +  G +    +  L  FT YS  ++A +      +GP +E  
Sbjct: 4779 ETV---------------LSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAE-- 4821

Query: 1046 TFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVG---------RE 1096
               T  + P  + +P++  L   +    W       G   +Y LQ  V            
Sbjct: 4822 -LRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTP 4880

Query: 1097 SEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQE 1137
            S+ +  Y G      + GLQ  T Y+ RV A      T+ E
Sbjct: 4881 SQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASE 4921



 Score =  116 bits (291), Expect = 1e-25
 Identities = 187/780 (23%), Positives = 303/780 (38%), Gaps = 75/780 (9%)

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
            L  L P  +Y V + A   +     S  ++ +T   AP+   PP +A    SSL L W  
Sbjct: 2019 LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLPSSLLLSWNP 2077

Query: 402  PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
            P      IT Y L  D        R  + GS+++  +T L     + F L+A   +G + 
Sbjct: 2078 PKKANGIITQYCLYMDG-------RLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTN 2130

Query: 462  YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND-N 520
             S  V+ YT    P+   +P L       + +QW +P   S   +  Y L +    +D  
Sbjct: 2131 -SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGI-LERYVLYMSNHTHDFT 2188

Query: 521  LFHPKYTGEDL--TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP 578
            ++   Y   +L     ++ +    +Y  +L A  T G    SE     T  D P     P
Sbjct: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC-TGGGCTVSEASEALTDEDIPEGVPAP 2247

Query: 579  LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
                  +   F+V W  P+   G  I  Y L + DG    N  E++Y      Y F    
Sbjct: 2248 KAHS-YSPDSFNVSWTEPEYPNGV-ITSYGLYL-DGILIHNSSELSYRA----YGFA--- 2297

Query: 639  PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
            P +L+  R    +  G +     +  RTL  AP +      +     ++ H+ W+ P   
Sbjct: 2298 PWSLHSFRVQACTAKGCA-LGPLVENRTLE-APPEGTVNVFVKTQGSRKAHVRWEAPFRP 2355

Query: 699  SGC---EVSEYSVEMTEPE-------DVASEVYHGPE--LECTVGNLLPGTVYRFRVRAL 746
            +G     V    +   +P        +V   +Y G E  L   +  L+P T Y  +V   
Sbjct: 2356 NGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNIS 2415

Query: 747  NDGGYGPYSDVSEITTAAGPPGQCKA---PCISCTPDGCVLVGWESPDSSGADIS-EYRL 802
            N  G    S +++  T A PPG       P +S      + V W +P  + A  S  Y+L
Sbjct: 2416 NSQG----SLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQL 2471

Query: 803  EWGEDEES---LELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
            +    + +   LEL  +      +E+ DL P  +Y  RL A N  G+  +S  +   T  
Sbjct: 2472 QMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSA-HSSWIPFMTAE 2530

Query: 859  SAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSI--TVGN 916
              P PV    +L         D  S  +++ W+ P  +   I  Y I L       T GN
Sbjct: 2531 DKPGPVVPPILL---------DVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGN 2581

Query: 917  TTMHVMKDLLPETTYRIRIQAINEIGAG--PFSQFIKAKTRPLPPLP---PRLECAAAGP 971
             T   +  L P T Y+ +++A    G    P SQ +      LP  P   P  E  +  P
Sbjct: 2582 VTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWT----LPGAPEGIPSPELFSDTP 2637

Query: 972  QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY----KVQRLTEFTCYS 1027
             S+ + W          E+     +++ + +    +    SH+     K   L+ +T Y 
Sbjct: 2638 TSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYE 2697

Query: 1028 FRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNY 1087
            +R+  ++  G    S     +T  S P  ++ P VT LE ++ ++ W+      GD ++Y
Sbjct: 2698 YRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSY 2757



 Score =  109 bits (273), Expect = 1e-23
 Identities = 194/856 (22%), Positives = 324/856 (37%), Gaps = 84/856 (9%)

Query: 279  IEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGK-YKIIYSGEE 337
            ++ P ++ + +R + + W  P  +S            Y + +S+   D   + +IY+  E
Sbjct: 2146 VDSPVLTVLDSRTIHIQWKQPRKIS-------GILERYVLYMSNHTHDFTIWSVIYNSTE 2198

Query: 338  L--ECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHRSKS 393
            L  +  L+ + P   Y +++ A      G C  SE     T    PE    PK    S  
Sbjct: 2199 LFQDHMLQYVLPGNKYLIKLGACTG---GGCTVSEASEALTDEDIPEGVPAPKAHSYSPD 2255

Query: 394  SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
            S  + W  P      IT+Y L  D    ++        S+   +     P   ++FR+ A
Sbjct: 2256 SFNVSWTEPEYPNGVITSYGLYLDGILIHNS-------SELSYRAYGFAPWSLHSFRVQA 2308

Query: 454  RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS---KPEGCSPEEVI-TY 509
                G +     V   TL   P+      +   G     ++W    +P G     V+ T 
Sbjct: 2309 CTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTG 2367

Query: 510  TLEIQEDEND----NLFHPKYTGED--LTCTVKNLKRSTQYKFRLTASNTEGK--SCPSE 561
               +    N+    N+    Y+GE+  L   +  L   T Y  ++  SN++G   + P  
Sbjct: 2368 IFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPIT 2427

Query: 562  VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
            + +   +PD   PP         T     V W  P  N      +Y L++  G+S     
Sbjct: 2428 IAMPPGAPDGVLPPRL----SSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFL 2483

Query: 622  EVAYSGSAT-EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVL 680
            E+  + SA+  Y  + L+P T Y  R    S G  S  S  +P  T    PG   PP +L
Sbjct: 2484 ELFSNPSASLSYEVSDLQPYTEYMFRLVA-SNGFGSAHSSWIPFMTAEDKPGPVVPPILL 2542

Query: 681  GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR 740
               K + + + W  P   +G  ++ Y++ +     + +    G    CTV +L P T Y+
Sbjct: 2543 D-VKSRMMLVTWQHPRKSNGV-ITHYNIYLHGRLYLRTP---GNVTNCTVMHLHPYTAYK 2597

Query: 741  FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS-- 798
            F+V A    G     +   + T  G P    +P +       V++ W+ P      +   
Sbjct: 2598 FQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENF 2657

Query: 799  --EYRLEWGEDEESLELIYHGTDTRF--EIRDLLPAAQYCCRLQAFNQAGAGPYSELVLC 854
              E R++  E+  +L  +      RF  +   L P  +Y  R+      G    S  V  
Sbjct: 2658 TIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEV 2717

Query: 855  QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV 914
             T  S P  V    V   EP DA        + + W+ P     +IL+Y I + D  IT+
Sbjct: 2718 TTRPSRPAGVQPPVVTVLEP-DA--------VQVTWKPPLIQNGDILSYEIHMPDPHITL 2768

Query: 915  GNTTMHVMKD----LLPETTYRIRIQAINEIGA--GPFSQFIKAKTRPLPPLPPRLECAA 968
             N T  V+      L+P T Y + I A +      G  ++ +       P +P  +   +
Sbjct: 2769 TNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS 2828

Query: 969  AGPQS---LKLKW---GDSNSKTHAAEDIVYTLQL-------EDRNKRFISIYRGPSHTY 1015
              P S   + + W      N      E +   +Q        ED N R+ +IY G    Y
Sbjct: 2829 VIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLN-RWHNIYSGTQWLY 2887

Query: 1016 KVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW- 1074
            + + L+ FT Y + +   +  G  P S   T +T   +P        + L   + ++ W 
Sbjct: 2888 EDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWA 2946

Query: 1075 -ETVPSMKGDPVNYIL 1089
              TV  ++G+   Y L
Sbjct: 2947 KPTVQDLQGEVEYYTL 2962



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 191/858 (22%), Positives = 320/858 (37%), Gaps = 97/858 (11%)

Query: 315  SYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT 374
            S + A++ +G D    ++Y G+E       L+P T+Y  RV A +             TT
Sbjct: 1893 STDSAVNCRGNDSI--LVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTT 1950

Query: 375  HSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLE-WDEG-----KRNSGFRQC 428
             +     P P ++   +  S+ + W  P+  G  I  Y+L+ + E      +  S   + 
Sbjct: 1951 GAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRG-VIEKYILKAYSEDSTRPPRMPSASAEF 2009

Query: 429  FFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
               S     LT L P   Y   L A    G +  S  +   T    PQ    P + ++  
Sbjct: 2010 VNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLP 2068

Query: 489  TWVTLQWSKPEGCSPEEVIT-YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFR 547
            + + L W+ P+      +IT Y L +    +  L    Y+G +   TV +L   T ++F 
Sbjct: 2069 SSLLLSWNPPK--KANGIITQYCLYM----DGRLI---YSGSEENYTVTDLAVFTPHQFL 2119

Query: 548  LTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
            L+A    G +  S VL+ T    P+    P    V   + S    ++W  P+   G  + 
Sbjct: 2120 LSACTHVGCTNSSWVLLYTAQLPPEHVDSP----VLTVLDSRTIHIQWKQPRKISGI-LE 2174

Query: 606  KYLLEITDGNSEANQWEVAYSGSA--TEYTFTHLKPGTLY--KLRACCISTGGHSQCSES 661
            +Y+L +++   +   W V Y+ +    ++   ++ PG  Y  KL AC   TGG    SE+
Sbjct: 2175 RYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC---TGGGCTVSEA 2231

Query: 662  LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVY 721
                T    P     P+          ++ W  P   +G  ++ Y + +         ++
Sbjct: 2232 SEALTDEDIPEGVPAPKAHSY-SPDSFNVSWTEPEYPNGV-ITSYGLYLD-----GILIH 2284

Query: 722  HGPELECTVGNLLPGTVYRFRVRALNDGG--YGPYSDVSEITTAAGPPGQCKAPCISCTP 779
            +  EL        P +++ FRV+A    G   GP   + E  T   PP       +    
Sbjct: 2285 NSSELSYRAYGFAPWSLHSFRVQACTAKGCALGP---LVENRTLEAPPEGTVNVFVKTQG 2341

Query: 780  DGCVLVGWESPDSSGADISEYRLEWG-------EDEESL----ELIYHGTDTRF--EIRD 826
                 V WE+P      ++   L  G        +  +L    +++Y G +T     I  
Sbjct: 2342 SRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDG 2401

Query: 827  LLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL 886
            L+P   Y  ++   N  G+   ++ +    P  APD      VL      A P S    L
Sbjct: 2402 LVPFTNYTVQVNISNSQGS-LITDPITIAMPPGAPDG-----VLPPRLSSATPTS----L 2451

Query: 887  VLNWEEPCNN---GSEILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQ 936
             + W  P  N   GS      +  GD++            +  + + DL P T Y  R+ 
Sbjct: 2452 QVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLV 2511

Query: 937  AINEIGAGPFS--QFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
            A N  G+   S   F+ A+ +P P +PP L       + + + W              Y 
Sbjct: 2512 ASNGFGSAHSSWIPFMTAEDKPGPVVPPIL--LDVKSRMMLVTWQHPRKSNGVITH--YN 2567

Query: 995  LQLEDRNKRFISIYRGPSHTYK--VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS 1052
            + L  R        R P +     V  L  +T Y F+++A +  G     E+ T  T   
Sbjct: 2568 IYLHGR-----LYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPG 2622

Query: 1053 VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY---KGEEAT 1109
             P  I +P +      S  I W+      G   N+ ++  V  + E   +    +     
Sbjct: 2623 APEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMR 2682

Query: 1110 F--QISGLQTNTDYRFRV 1125
            F  + S L   T Y +RV
Sbjct: 2683 FIDKTSALSPWTKYEYRV 2700



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 137/613 (22%), Positives = 230/613 (37%), Gaps = 54/613 (8%)

Query: 537  NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWD 594
            NLK    Y++R++A N+ G+     V   T    P    PPT   +          + W 
Sbjct: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDN--LEDTIVLNWR 3522

Query: 595  PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
             P  + G  I  Y + + +G        +++S       F        Y+L+AC ++  G
Sbjct: 3523 KPIQSNGPII--YYILLRNGIERFRGTSLSFSDKEGIQPFQEYS----YQLKACTVA--G 3574

Query: 655  HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE 714
             +  S+ +   T  + P    PP +        +HL W VP   +G  + EY +      
Sbjct: 3575 CATSSKVVAATTQGV-PESILPPSITAL-SAVALHLSWSVPEKSNGV-IKEYQIRQVGKG 3631

Query: 715  DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPC 774
             + ++       + TV  L P T Y F + A    G          T  A P G    P 
Sbjct: 3632 LIHTDT--TDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPR 3689

Query: 775  ISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYC 834
                    V + W  P+     +S+Y+L       +L  +    +  F  ++L P ++Y 
Sbjct: 3690 HIIINSTTVELYWSLPEKPNGLVSQYQL---SRNGNLLFLGGSEEQNFTDKNLEPNSRYT 3746

Query: 835  CRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC 894
             +L+     G    S+  + QTP S P+ +         P +     P +  V  W  P 
Sbjct: 3747 YKLEV-KTGGGSSASDDYIVQTPMSTPEEI-------YPPYNITVIGPYSIFVA-WIPPG 3797

Query: 895  NNGSEI-LAYTIDLGDTSIT-----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
                EI + Y + L D S+T     VG+    ++++L P T Y IRIQA      G  S+
Sbjct: 3798 ILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857

Query: 949  -FIKA-KTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAED-IVY--TLQLEDRNKR 1003
             F+K  +  P+    P L+  A G   +++KW           +  +Y     +E+ +  
Sbjct: 3858 MFVKTPEAAPMDLNSPVLK--ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVL 3915

Query: 1004 FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPP-TIKAPRV 1062
            F+          +   L  FT Y +R++A +   +G     ++ + T   PP    AP  
Sbjct: 3916 FVWSEGALEFMDEGDTLRPFTLYEYRVRACN--SKGSVESLWSLTQTLEAPPQDFPAPWA 3973

Query: 1063 TQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE--------YKQVYKGEEATFQISG 1114
                 +S  + W T P      +++   V   R  +        +    KG      + G
Sbjct: 3974 QATSAHSVLLNW-TKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYG 4032

Query: 1115 LQTNTDYRFRVCA 1127
            L+  T YR  V A
Sbjct: 4033 LEPFTTYRIGVVA 4045



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 134/633 (21%), Positives = 247/633 (39%), Gaps = 60/633 (9%)

Query: 526  YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
            Y G++ +     L+  T+Y +R+ AS+ EG S  S+     T+   P     P     + 
Sbjct: 1909 YQGKEQSVYEGGLQPFTEYLYRVIASH-EGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLN 1967

Query: 586  SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT--------FTHL 637
             +   V WD P   G  E  KY+L+     SE +        ++ E+          T L
Sbjct: 1968 GYSIEVTWDEPVVRGVIE--KYILK---AYSEDSTRPPRMPSASAEFVNTSNLTGILTGL 2022

Query: 638  KPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPAS 697
             P   Y +     +  G ++ S +L + T   AP + +PP     P    + L W+ P  
Sbjct: 2023 LPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPS--SLLLSWNPPKK 2080

Query: 698  ESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDV 757
             +G  +++Y + M         +Y G E   TV +L   T ++F + A    G    S V
Sbjct: 2081 ANGI-ITQYCLYMD-----GRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWV 2134

Query: 758  SEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLEL---I 814
              + TA  PP    +P ++      + + W+ P      +  Y L          +   I
Sbjct: 2135 L-LYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVI 2193

Query: 815  YHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEE 872
            Y+ T+   +  ++ +LP  +Y  +L A    G           T + A + ++   + E 
Sbjct: 2194 YNSTELFQDHMLQYVLPGNKYLIKLGACTGGGC----------TVSEASEALTDEDIPEG 2243

Query: 873  EPLD-AYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTY 931
             P   A+  SP +  V +W EP      I +Y + L    I   +   +      P + +
Sbjct: 2244 VPAPKAHSYSPDSFNV-SWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLH 2302

Query: 932  RIRIQAINEIGAGPFSQFIKAKTRPLPPLPP-RLECAAAGPQSLKLKWG----DSNSKTH 986
              R+QA    G       ++ +T   PP     +     G +   ++W      +   TH
Sbjct: 2303 SFRVQACTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTH 2361

Query: 987  AAEDI-VYTLQLEDRNKRFISI----YRGPSHTYKV--QRLTEFTCYSFRIQAASEAGEG 1039
            +     ++ +     N   +++    Y G      V    L  FT Y+ ++  ++  G  
Sbjct: 2362 SVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGS- 2420

Query: 1040 PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN--YILQVLVGRES 1097
              ++  T +     P  +  PR++     S +++W T P+    P +  Y LQ+  G  +
Sbjct: 2421 LITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWST-PARNNAPGSPRYQLQMRSGDST 2479

Query: 1098 E-YKQVYKGEEAT--FQISGLQTNTDYRFRVCA 1127
              + +++    A+  +++S LQ  T+Y FR+ A
Sbjct: 2480 HGFLELFSNPSASLSYEVSDLQPYTEYMFRLVA 2512



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 130/549 (23%), Positives = 202/549 (36%), Gaps = 49/549 (8%)

Query: 278  GIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE 337
            GI  P++ +    +V++SW PP        +GL   ++ E  +  KG++    ++     
Sbjct: 2626 GIPSPELFSDTPTSVIISWQPPTH-----PNGLVENFTIERRV--KGKEEVTTLVTLPRS 2678

Query: 338  LECNLKD----LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
                  D    L P T Y  RV         + S  V  TT    P    PP +      
Sbjct: 2679 HSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPD 2738

Query: 394  SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
            ++ + WK P+     I +Y +   +             SQK   +T L P   Y+  + A
Sbjct: 2739 AVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQK---VTHLIPFTNYSVTIVA 2795

Query: 454  RNDIGTSGY------SQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW---SKPEGCSPE 504
             +  G +GY      S      T   +PQ      ++    ++V + W   SKP G +  
Sbjct: 2796 CS--GGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLR 2853

Query: 505  -----EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
                   I   L     E+ N +H  Y+G       K L R T Y++ L   N+ G +  
Sbjct: 2854 YELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPS 2913

Query: 560  SEVLVCTTSPDRPGPPTRPL-VKGPVTSH-GFSVKWDPP--KDNGGSEILKYLLEITDGN 615
             EV V T +    G P R   +   V +H    V+W  P  +D  G E+  Y L  +   
Sbjct: 2914 REVTVTTLA----GLPERGANLTASVLNHTAIDVRWAKPTVQDLQG-EVEYYTLFWSSAT 2968

Query: 616  SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCR 675
            S  +   +        +   HLKP T Y +    +  G HS  S  L   T    P    
Sbjct: 2969 SNDS---LKILPDVNSHVIGHLKPNTEYWI-FISVFNGVHSINSAGLHATTCDGEPQGML 3024

Query: 676  PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
            PP V+       V + W  P++ +G  V+EYS+ +            G  +   + +L P
Sbjct: 3025 PPEVV-IINSTAVRVIWTSPSNPNGV-VTEYSIYVNNKLYKTGMNVPGSFI---LRDLSP 3079

Query: 736  GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
             T+Y  +V           S+ ++ITT    P     P I       + + W SP     
Sbjct: 3080 FTIYDIQVEVCTIYACVK-SNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNG 3138

Query: 796  DISEYRLEW 804
             I  Y L W
Sbjct: 3139 IILGYDLLW 3147



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 110/460 (23%), Positives = 164/460 (35%), Gaps = 55/460 (11%)

Query: 384  PPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
            PP+   +S S++ L W  P    +    Y L  D  +  +   Q  +  Q     T L P
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLD-TDLLP 1117

Query: 444  AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA----PRLVRAGITWVTLQWSKPE 499
               Y++ +   N  G    S   V  T    P +P        ++  G   VTL W+   
Sbjct: 1118 YTKYSYYIETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173

Query: 500  GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KS 557
              S   +  Y L              Y G + + T+ NL    +Y F + A  + G   S
Sbjct: 1174 NQSGP-IEKYILSCAPLAGGQPC-VSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHS 1231

Query: 558  CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL-------- 609
             P  V      P R  PP        ++S    V+W PP +  G  I++Y L        
Sbjct: 1232 LPITVTTAQAPPQRLSPPKMQ----KISSTELHVEWSPPAELNGI-IIRYELYMRRLRST 1286

Query: 610  -EITDGNSEANQ---W-----------EVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
             E T   S   Q   W           E A     T  T T L+P T Y+ R   ++  G
Sbjct: 1287 KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG 1346

Query: 655  HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE-SGCEVSEYSVEMTEP 713
             S  S  +  RT   AP    PP V     +  +++ W+ PA   +  +V  Y + M   
Sbjct: 1347 -SVSSAWVSERTGESAPVFMIPPSVFPLSSYS-LNISWEKPADNVTRGKVVGYDINMLSE 1404

Query: 714  ED-------VASEVYH---GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA 763
            +          S++ H     EL  TV  L P  +Y F +   N  G    +  +  T A
Sbjct: 1405 QSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLA 1464

Query: 764  AGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE 803
            A  P Q + P +       + + W  P+        Y+LE
Sbjct: 1465 AA-PAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 99/445 (22%), Positives = 165/445 (37%), Gaps = 41/445 (9%)

Query: 700  GCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
            GC  ++ +V     + +   VY G E     G L P T Y +RV A ++GG   YSD S 
Sbjct: 1890 GCLSTDSAVNCRGNDSIL--VYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSDWSR 1946

Query: 760  ITTAAGPPGQCKAPCISCTPDG-CVLVGWESPDSSGADISEYRLE-WGED--------EE 809
              T    P     P    + +G  + V W+ P   G  I +Y L+ + ED          
Sbjct: 1947 GRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRGV-IEKYILKAYSEDSTRPPRMPSA 2005

Query: 810  SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCV 869
            S E +     T   +  LLP   Y   L A   AG    S  +   TP  AP  V     
Sbjct: 2006 SAEFVNTSNLTGI-LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEV----- 2059

Query: 870  LEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
              + P+     S  + L+L+W  P      I  Y + +    I  G+   + + DL   T
Sbjct: 2060 --QPPV---AKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSGSEENYTVTDLAVFT 2114

Query: 930  TYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGDSNSKTH 986
             ++  + A   +G    S ++   T  LPP     P L       +++ ++W      + 
Sbjct: 2115 PHQFLLSACTHVGC-TNSSWVLLYTAQLPPEHVDSPVL--TVLDSRTIHIQWKQPRKISG 2171

Query: 987  AAEDIVYTLQLEDRNKRFISIYRGPSHTYK---VQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              E  V  +     +    S+    +  ++   +Q +     Y  ++ A +  G    SE
Sbjct: 2172 ILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT-GGGCTVSE 2230

Query: 1044 TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY 1103
                 T + +P  + AP+      +S  + W       G   +Y      G   +   ++
Sbjct: 2231 ASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSY------GLYLDGILIH 2284

Query: 1104 KGEEATFQISGLQTNTDYRFRVCAC 1128
               E +++  G    + + FRV AC
Sbjct: 2285 NSSELSYRAYGFAPWSLHSFRVQAC 2309



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 135/652 (20%), Positives = 230/652 (35%), Gaps = 73/652 (11%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
            P + ++++R ++++W  P        +G+   Y+  +        G+  +   G    C 
Sbjct: 2539 PILLDVKSRMMLVTWQHP-----RKSNGVITHYNIYL-------HGRLYLRTPGNVTNCT 2586

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC--APECPFPPKLAHRSKSSLTLQW 399
            +  L P T Y  +V A  +  KG    P S T  +   APE    P+L   + +S+ + W
Sbjct: 2587 VMHLHPYTAYKFQVEACTS--KGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISW 2644

Query: 400  KAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHC-----KLTKLCPAMGYTFRLAAR 454
            + P      + N+ +E    K            + H      K + L P   Y +R+   
Sbjct: 2645 QPPTHPNGLVENFTIE-RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMS 2703

Query: 455  NDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
               G +  S  V   T  + P     P +       V + W KP      ++++Y + + 
Sbjct: 2704 TLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTW-KPPLIQNGDILSYEIHMP 2762

Query: 515  EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA-SNTEG------KSCPSEVLVCTT 567
            +    ++     T   L+  V +L   T Y   + A S   G      +S P+ V    T
Sbjct: 2763 D---PHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPT 2819

Query: 568  SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE-------ITDGNSEANQ 620
             P   G    PL   P++     + W PP    G  +   LL         ++   + N+
Sbjct: 2820 VPQNVG----PLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNR 2875

Query: 621  WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP--GQCRPPR 678
            W   YSG+   Y    L   T Y+      ++ G +  S  + V TL+  P  G      
Sbjct: 2876 WHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTAS 2934

Query: 679  VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC-TVGNLLPGT 737
            VL    H  + + W  P  +      EY             +   P++    +G+L P T
Sbjct: 2935 VL---NHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNT 2991

Query: 738  VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
             Y   +   N G +   S     TT  G P     P +       V V W SP +    +
Sbjct: 2992 EYWIFISVFN-GVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVV 3050

Query: 798  SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTP 857
            +EY +          +   G+   F +RDL P   Y  +++              +C   
Sbjct: 3051 TEYSIYVNNKLYKTGMNVPGS---FILRDLSPFTIYDIQVE--------------VCTIY 3093

Query: 858  ASAPDPVSTLCVLEEEPLDAYPDS----PSACLVLNWEEPCNNGSEILAYTI 905
            A      + +  +E+ P D    +     S  L ++W  P      IL Y +
Sbjct: 3094 ACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 69/258 (26%), Positives = 109/258 (42%), Gaps = 39/258 (15%)

Query: 891  EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
            EE C++  E    TI  G       NT  +   +L P  TY  RI A N  G G  S+ +
Sbjct: 3441 EEMCSSAEE----TIHTGSV-----NTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAV 3490

Query: 951  KAKTR---PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI 1007
            +A+T+   P    PP          ++ L W        +   I+Y + L +  +RF   
Sbjct: 3491 RARTKEDVPQGVSPPTWTKIDNLEDTIVLNW---RKPIQSNGPIIYYILLRNGIERF--- 3544

Query: 1008 YRGPSHTYKVQR-LTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
             RG S ++  +  +  F  YS++++A + AG    S+    +TT+ VP +I  P +T L 
Sbjct: 3545 -RGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVA-ATTQGVPESILPPSITALS 3602

Query: 1067 GNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKG-------EEATFQISGLQTNT 1119
              +  + W       G          V +E + +QV KG       +     ++GLQ  T
Sbjct: 3603 AVALHLSWSVPEKSNG----------VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYT 3652

Query: 1120 DYRFRVCACRRCLDTSQE 1137
            +Y F + AC     TS E
Sbjct: 3653 NYSFTLTACTSAGCTSSE 3670



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 83/325 (25%), Positives = 126/325 (38%), Gaps = 54/325 (16%)

Query: 327  GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFP 384
            G+  + Y G E    + +L P   Y   V A      G C  S P++ TT    P+   P
Sbjct: 1192 GQPCVSYEGHETSATIWNLVPFAKYDFSVQAC---TSGGCLHSLPITVTTAQAPPQRLSP 1248

Query: 385  PKLAHRSKSSLTLQWKAPIDNGSKITNYLL-------------EWDEGKRNSGF------ 425
            PK+   S + L ++W  P +    I  Y L             E     ++SG+      
Sbjct: 1249 PKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSF 1308

Query: 426  -----RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
                        Q    +T L P   Y FR+ A N  G S  S  V   T  + P     
Sbjct: 1309 VESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIP 1367

Query: 481  PRLVRAGITWVTLQWSKP-EGCSPEEVITYTLEIQEDEN---------DNLFHPKYTGED 530
            P +       + + W KP +  +  +V+ Y + +  +++           L H     ++
Sbjct: 1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTA-KSQE 1426

Query: 531  LTCTVKNLKRSTQYKFRLTASNTEG----KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
            L+ TV+ LK    Y+F +T  N+ G     S   + L    +  RP     PLVKG + S
Sbjct: 1427 LSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRP-----PLVKG-INS 1480

Query: 587  HGFSVKWDPPKD-NGGSEILKYLLE 610
                +KW PP++ NG S I  Y LE
Sbjct: 1481 TTIHLKWFPPEELNGPSPI--YQLE 1503



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 99/445 (22%), Positives = 175/445 (39%), Gaps = 52/445 (11%)

Query: 277  SGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGE 336
            +G++ P V+ ++  AV ++W PP+ +  G         SYE+ + D           +  
Sbjct: 2725 AGVQPPVVTVLEPDAVQVTWKPPL-IQNGD------ILSYEIHMPDPHIT---LTNVTSA 2774

Query: 337  ELECNLKDLRPATDYHVRVYAMY--NSVKGSCSE--PVSFTTHSCAPECPFPPKLAHRSK 392
             L   +  L P T+Y V + A    N   G C+E  P   TTH   P+   P  +   S+
Sbjct: 2775 VLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSE 2834

Query: 393  SSLTLQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
            S + + W+ P   NG  +   LL          +  +  + +   + G+Q   +   L  
Sbjct: 2835 SYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSR 2894

Query: 444  AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
               Y + L   N +G +  S+EV   TL  +P+  +         T + ++W+KP     
Sbjct: 2895 FTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDL 2953

Query: 504  E-EVITYTL-EIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
            + EV  YTL       ND+L   K   +  +  + +LK +T+Y   ++  N    S  S 
Sbjct: 2954 QGEVEYYTLFWSSATSNDSL---KILPDVNSHVIGHLKPNTEYWIFISVFNGV-HSINSA 3009

Query: 562  VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
             L  TT    P     P V   + S    V W  P +  G  + +Y + +   N++  + 
Sbjct: 3010 GLHATTCDGEPQGMLPPEVV-IINSTAVRVIWTSPSNPNG-VVTEYSIYV---NNKLYKT 3064

Query: 622  EVAYSGSATEYTFTHLKPGTLYKLRA------CCISTGGHSQCSESLPVRTLSIAPGQCR 675
             +   GS   +    L P T+Y ++        C+ + G         + T+   P    
Sbjct: 3065 GMNVPGS---FILRDLSPFTIYDIQVEVCTIYACVKSNG-------TQITTVEDTPSDIP 3114

Query: 676  PPRVLGRPKHKEVHLEWDVPASESG 700
             P + G    + + ++W  P   +G
Sbjct: 3115 TPTIRGITS-RSLQIDWVSPRKPNG 3138



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 92/419 (21%), Positives = 146/419 (34%), Gaps = 56/419 (13%)

Query: 732  NLLPGTVYRFRVRALNDGGYGPYSDV-----SEITTAAGPPGQCKAPCISCTPDGCVLVG 786
            NL P   Y +R+ A N  G G    V      ++     PP   K   +  T    +++ 
Sbjct: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDT----IVLN 3520

Query: 787  WESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGA 845
            W  P  S   I  Y L     E      + GT   F  ++ + P  +Y  +L+A   AG 
Sbjct: 3521 WRKPIQSNGPIIYYILLRNGIER-----FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGC 3575

Query: 846  GPYSELVLCQT---PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
               S++V   T   P S   P  T                +  L L+W  P  +   I  
Sbjct: 3576 ATSSKVVAATTQGVPESILPPSITAL-------------SAVALHLSWSVPEKSNGVIKE 3622

Query: 903  YTIDLGDTSITVGNTT---MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
            Y I      +   +TT    H +  L P T Y   + A    G      F+    +  P 
Sbjct: 3623 YQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPE 3682

Query: 960  ---LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYK 1016
               + PR         +++L W    S       +V   QL  RN   + +       + 
Sbjct: 3683 GVWVTPR--HIIINSTTVELYW----SLPEKPNGLVSQYQL-SRNGNLLFLGGSEEQNFT 3735

Query: 1017 VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP-RVTQLEGNSCEILW- 1074
             + L   + Y+++++  +  G    S+ Y   T  S P  I  P  +T +   S  + W 
Sbjct: 3736 DKNLEPNSRYTYKLEVKTGGGSSA-SDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWI 3794

Query: 1075 ---ETVPSMKGDPVNYILQVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRVCACR 1129
                 +P +   PV Y   VL+   S     +  G   +  +  L   T Y  R+ AC+
Sbjct: 3795 PPGILIPEI---PVEY--NVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQ 3848



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 93/378 (24%), Positives = 144/378 (38%), Gaps = 51/378 (13%)

Query: 560  SEVLVCTTSPDRPGPPTRPLVKGPV-TSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
            + +L C+ +P +  PP     +G V +S   ++ W PP D+  +  L Y L + DG  E 
Sbjct: 1045 NNLLGCSKTPFQQPPP-----RGQVQSSSAINLSWSPP-DSPNAHWLTYSL-LRDG-FEI 1096

Query: 619  NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
               E  Y  S   +  T L P T Y       +  G ++ S ++  +T    P       
Sbjct: 1097 YTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLS 1155

Query: 679  VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV-YHGPELECTVGNLLPGT 737
             +       V L W   +++SG  + +Y +           V Y G E   T+ NL+P  
Sbjct: 1156 YIIPIGSDSVTLTWTTLSNQSG-PIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFA 1214

Query: 738  VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
             Y F V+A   GG   +S    +TTA  PP +   P +       + V W  P      I
Sbjct: 1215 KYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGII 1273

Query: 798  SEYRL---------EWGEDEESL-----------------ELIYHGTDTRFEIRDLLPAA 831
              Y L         E   +E  +                 E       T   I  L P  
Sbjct: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333

Query: 832  QYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE 891
            +Y  R+ A N AG+   S  V  +T  SAP  +    V    PL +Y       L ++WE
Sbjct: 1334 KYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSVF---PLSSY------SLNISWE 1383

Query: 892  EPCNN--GSEILAYTIDL 907
            +P +N    +++ Y I++
Sbjct: 1384 KPADNVTRGKVVGYDINM 1401



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 99/454 (21%), Positives = 161/454 (35%), Gaps = 69/454 (15%)

Query: 756  DVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRL-EWGEDEESLELI 814
            DV+ +   +  P Q   P         + + W  PDS  A    Y L   G +  + E  
Sbjct: 1043 DVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQ 1102

Query: 815  YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP 874
            Y  +   F   DLLP  +Y   ++  N  G+   S  V  +T    P+   TL  +    
Sbjct: 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGS-TRSVAVTYKTKPGVPEGNLTLSYIIPIG 1161

Query: 875  LDAYPDSPSACLVLNWEEPCNNGSEILAYTIDL-----GDTSITV-GNTTMHVMKDLLPE 928
             D+        + L W    N    I  Y +       G   ++  G+ T   + +L+P 
Sbjct: 1162 SDS--------VTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPF 1213

Query: 929  TTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGD----- 980
              Y   +QA    G    S  I   T   PP    PP+++  ++    L ++W       
Sbjct: 1214 AKYDFSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISS--TELHVEWSPPAELN 1270

Query: 981  --------------SNSKTHAAEDIVYTLQ--------LEDRNKRFISIYRGPSHTYKVQ 1018
                          S  +T + E  V+           +E  N+  +   + P     + 
Sbjct: 1271 GIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL---KPPQTMTTIT 1327

Query: 1019 RLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
             L  +T Y FR+ A + AG    S   +  T +S P  +  P V  L   S  I WE   
Sbjct: 1328 GLEPYTKYEFRVLAVNMAGSVS-SAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386

Query: 1079 S--MKGDPVNYILQVLVGRE---------SEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                +G  V Y + +L  +          S+     K +E ++ + GL+    Y F +  
Sbjct: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446

Query: 1128 CRR--CLDTSQELSGAFSPSAAFVLQRSEVMLTG 1159
            C    C+ ++   SGA    AA   Q    ++ G
Sbjct: 1447 CNSVGCVTSA---SGAGQTLAAAPAQLRPPLVKG 1477



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 92/481 (19%), Positives = 168/481 (34%), Gaps = 51/481 (10%)

Query: 649  CISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYS 707
            C+ +  H   +  L     S  P Q  PPR  G+ +    ++L W  P S +   ++ YS
Sbjct: 1035 CVPSASHLDVNNLLGC---SKTPFQQPPPR--GQVQSSSAINLSWSPPDSPNAHWLT-YS 1088

Query: 708  VEMTEPEDVASEVYHGPELECTVG-NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP 766
            +     E   +E  +   ++  +  +LLP T Y + +   N  G      V+  T    P
Sbjct: 1089 LLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVP 1148

Query: 767  PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELI-YHGTDTRFEIR 825
             G      I       V + W +  +    I +Y L           + Y G +T   I 
Sbjct: 1149 EGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIW 1208

Query: 826  DLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP-----DPVSTLCVLEEEPLDAYPD 880
            +L+P A+Y   +QA    G      L +  T A AP      P        E  ++  P 
Sbjct: 1209 NLVPFAKYDFSVQACTSGGC--LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPP 1266

Query: 881  SPSACLVLNWE----------EPCNNGSEILAYT--------IDLGDTSITVGNTTMHVM 922
            +    +++ +E          E  +  S +   +        ++  + +      TM  +
Sbjct: 1267 AELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTI 1326

Query: 923  KDLLPETTYRIRIQAINEIGAGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWG 979
              L P T Y  R+ A+N  G+   S ++  +T    P+  +PP +        SL + W 
Sbjct: 1327 TGLEPYTKYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSV--FPLSSYSLNISWE 1383

Query: 980  DSNSKTHAAEDIVYTLQLEDRN----------KRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
                     + + Y + +               + +   +    +Y V+ L  +  Y F 
Sbjct: 1384 KPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFT 1443

Query: 1030 IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
            I   +  G    S +    T  + P  ++ P V  +   +  + W     + G    Y L
Sbjct: 1444 ITLCNSVG-CVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502

Query: 1090 Q 1090
            +
Sbjct: 1503 E 1503



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 52/186 (27%), Positives = 73/186 (39%), Gaps = 23/186 (12%)

Query: 345  LRPATDYHVRVYAMYNSVKGSCSEP-VSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
            L P T Y  RV A+  ++ GS S   VS  T   AP    PP +   S  SL + W+ P 
Sbjct: 1329 LEPYTKYEFRVLAV--NMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386

Query: 404  DN--GSKITNYLLEW--DEGKRNS---GFRQCFFGSQKH---CKLTKLCPAMGYTFRLAA 453
            DN    K+  Y +    ++  + S    F Q    ++       +  L P   Y F +  
Sbjct: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446

Query: 454  RNDIG----TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
             N +G     SG  Q     TL   P     P +     T + L+W  PE  +    I Y
Sbjct: 1447 CNSVGCVTSASGAGQ-----TLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPI-Y 1500

Query: 510  TLEIQE 515
             LE +E
Sbjct: 1501 QLERRE 1506


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  145 bits (367), Expect = 2e-34
 Identities = 173/719 (24%), Positives = 285/719 (39%), Gaps = 74/719 (10%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVAL-SDKGRDGKYKIIYSGEELEC 340
            P V+   A ++ L+W           SG   P SY +     K  +  YK I        
Sbjct: 329  PVVTESTATSITLTW----------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 378

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPE-CPFPPKLAHRSKSSLTLQW 399
            ++  L P +DY  RV A+ N  +G  SEPV   T   AP   P   +    S +++ +QW
Sbjct: 379  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 400  KAPIDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
            K P +   +I  Y + +  D  +  + + +      +   +  L P   Y+ ++ A   I
Sbjct: 439  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498

Query: 458  GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDE 517
            G    S ++   T   +P  P   +      T + L W+ P     + +  Y L  ++ E
Sbjct: 499  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS---DTIANYELVYKDGE 555

Query: 518  NDNLFHPKYTGEDLTC-TVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
            +      + T E  T   ++ LK ++ Y FRL A + +G    +  +   T   +P  P 
Sbjct: 556  HGE--EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP 613

Query: 577  RPLVKGPVTSHGFSVKWDPP---KDNGGSEILKYLLEIT--DGNSEANQWEVAYSGSATE 631
            + +     +S    V W PP   K NG   I +Y ++ T  DG  +     +      T+
Sbjct: 614  QDISCTSPSSTSILVSWQPPPVEKQNG--IITEYSIKYTAVDGEDDKPHEILGIPSDTTK 671

Query: 632  YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVH 689
            Y    L+  T Y++     +  G    S S+ +RT    P    PPR +         V 
Sbjct: 672  YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG--PPRKVEVEAVNSTSVK 729

Query: 690  LEWDVPASES------GCEVSEYSVEMTEPE-----------DVASEVYHGPELECTVGN 732
            + W  P          G +V    +E  EP+           D   E     E +  +  
Sbjct: 730  VSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISG 789

Query: 733  LLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS 792
            L P T Y   V A    G G  S    ++T    PG+ +   I+ T     L+ W  P  
Sbjct: 790  LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL-VINHTQMNTALIQWHPPVD 848

Query: 793  SGADISEYRLEWG-EDEESLELI-YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
            +   +  YRL++G +D E L  + +   +  F   D+   A Y  RL A N+ G G   E
Sbjct: 849  TFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EE 906

Query: 851  LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP--CNNGSEILAYTIDL 907
            +V      S P+ V T       P + + +  ++  V L+W+ P        I  YT+  
Sbjct: 907  MV---KEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 958

Query: 908  GDTSITV---------GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPL 957
             D +I +          +TTM  +  L P+TTY ++++A    G GP+S  ++ +T P+
Sbjct: 959  RDINIPLLPMEQLIVPADTTM-TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1016



 Score =  120 bits (302), Expect = 6e-27
 Identities = 176/783 (22%), Positives = 290/783 (37%), Gaps = 83/783 (10%)

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
            L D+R + +Y     +    +     E ++  T    P+ P  P +   + +S+TL W +
Sbjct: 291  LNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTWDS 345

Query: 402  PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
               N   ++ Y+++         +++    +     +  L P   Y FR+ A N+IG   
Sbjct: 346  --GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGP 403

Query: 462  YSQEVVCYTLGNIPQMPSAPRLVRAGI---TWVTLQWSKPE---GCSPEEVITYTLEIQE 515
             S+ V+  T    P   SAPR V+A +   T + +QW +PE   G      + YT++  +
Sbjct: 404  PSEPVLTQTSEQAPS--SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              N+ + H     +    T+ NL     Y  ++ A  + G    S  +   T    PG P
Sbjct: 462  HVNNWMKHN--VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 576  TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 635
                 + P +     + W PP+ +    I  Y L   DG     Q      G  T Y   
Sbjct: 520  LNFKAE-PESETSILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPG--TSYRLQ 573

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVHLEWD 693
             LKP +LY  R    S  G    +  +  RT+   P    PP+ +    P    + + W 
Sbjct: 574  GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQ 631

Query: 694  VPASES-GCEVSEYSVEMTE---PEDVASEVYHGPE--LECTVGNLLPGTVYRFRVRALN 747
             P  E     ++EYS++ T     +D   E+   P    +  +  L   T YR  V A  
Sbjct: 632  PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 691

Query: 748  DGGYGPYSDVSEITT----AAGPPGQCKAPCISCTPDGCVLVGWESPDSS-------GAD 796
            D G GP S    I T     +GPP + +   ++ T    V V W SP  +       G  
Sbjct: 692  DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS---VKVSWRSPVPNKQHGQIRGYQ 748

Query: 797  ISEYRLEWGEDE-ESLELIYHGTDTRFEIRD----------LLPAAQYCCRLQAFNQAGA 845
            +   R+E GE + + +       D ++E  D          L P   Y   + A+   G 
Sbjct: 749  VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGD 808

Query: 846  GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
            G  S+          P  VST   +  +P      +     ++ W  P +    +  Y +
Sbjct: 809  GARSK----------PKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRL 858

Query: 906  DLGD------TSITVGNTTMH-VMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP-- 956
              G       T++       H    D+    +Y  R+ A N++G G   + +K  + P  
Sbjct: 859  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEE 916

Query: 957  LPP-LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR---GPS 1012
            +P   P  L        S++L W              YTL   D N   + + +      
Sbjct: 917  VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 976

Query: 1013 HTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T  +  L   T Y  +++A +  G GP+S +  F T        K   V  +   S  +
Sbjct: 977  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLL 1036

Query: 1073 LWE 1075
             WE
Sbjct: 1037 SWE 1039



 Score =  118 bits (295), Expect = 4e-26
 Identities = 174/767 (22%), Positives = 298/767 (38%), Gaps = 135/767 (17%)

Query: 457  IGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
            + T G  + +   T+  +P+ P  P +  +  T +TL W   +  +PE V  Y ++ +  
Sbjct: 305  MSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTW---DSGNPEPVSYYIIQHKPK 361

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             ++ L+           +V  L   + Y+FR+ A N  G+  PSE ++  TS   P    
Sbjct: 362  NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 421

Query: 577  RPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFT 635
            R +    ++S    V+W  P++  G +I  Y +  T D     N W       +   T  
Sbjct: 422  RDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDV 694
            +L P   Y ++    ++ G    S  + V T +  PGQ  P      P+ +  + L W  
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTP 538

Query: 695  PASESGCEVSEYSVEMTEPEDVASEVYHGPELECTV--------GNLLPGTVYRFRVRAL 746
            P S++   ++ Y +   + E       HG E   T+          L P ++Y FR+ A 
Sbjct: 539  PRSDT---IANYELVYKDGE-------HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAAR 588

Query: 747  NDGGYG-PYSDVSEITTAAGPPGQCKAPCISCTPDG--CVLVGWESP--DSSGADISEYR 801
            +  G G   +++S  T  + P        ISCT      +LV W+ P  +     I+EY 
Sbjct: 589  SPQGLGASTAEISARTMQSKP--SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYS 646

Query: 802  LEW----GEDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT 856
            +++    GED++  E++   +D T++ +  L    +Y   + A    G GP S  VL +T
Sbjct: 647  IKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRT 706

Query: 857  ----PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN--GSEILAYTID---- 906
                P+  P  V    V             S  + ++W  P  N    +I  Y +     
Sbjct: 707  NEDVPSGPPRKVEVEAV------------NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRM 754

Query: 907  ---------------LGDTSITVGNTTMH--VMKDLLPETTYRIRIQAINEIGAGPFSQF 949
                           L D      +TT H  ++  L PET+Y + + A    G G  S+ 
Sbjct: 755  ENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKP 814

Query: 950  IKAKTRPLPPLPPRL----------------ECAAAGP-QSLKLKWGDSNSKTHAAEDIV 992
                T    P  PRL                     GP Q  +LK+G  + +       +
Sbjct: 815  KLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEP------L 868

Query: 993  YTLQLEDRNKRFIS--IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             TL+  ++   F +  I++G S             Y FR+ A ++ G G        S  
Sbjct: 869  TTLEFSEKEDHFTATDIHKGAS-------------YVFRLSARNKVGFGE-EMVKEISIP 914

Query: 1051 KSVPPTIKAPRVTQLEG---NSCEILWETVPSMKGDPVNYILQ-VLVGRESE-----YKQ 1101
            + VP     P+    EG    S ++ W+  P +  +    I +  L+ R+        +Q
Sbjct: 915  EEVPTGF--PQNLHSEGTTSTSVQLSWQ--PPVLAERNGIITKYTLLYRDINIPLLPMEQ 970

Query: 1102 VYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAF 1148
            +    + T  ++GL+ +T Y  +V A       + +  G +SPS  F
Sbjct: 971  LIVPADTTMTLTGLKPDTTYDVKVRA------HTSKGPGPYSPSVQF 1011


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  145 bits (367), Expect = 2e-34
 Identities = 173/719 (24%), Positives = 285/719 (39%), Gaps = 74/719 (10%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVAL-SDKGRDGKYKIIYSGEELEC 340
            P V+   A ++ L+W           SG   P SY +     K  +  YK I        
Sbjct: 316  PVVTESTATSITLTW----------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 365

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPE-CPFPPKLAHRSKSSLTLQW 399
            ++  L P +DY  RV A+ N  +G  SEPV   T   AP   P   +    S +++ +QW
Sbjct: 366  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425

Query: 400  KAPIDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
            K P +   +I  Y + +  D  +  + + +      +   +  L P   Y+ ++ A   I
Sbjct: 426  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485

Query: 458  GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDE 517
            G    S ++   T   +P  P   +      T + L W+ P     + +  Y L  ++ E
Sbjct: 486  GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS---DTIANYELVYKDGE 542

Query: 518  NDNLFHPKYTGEDLTC-TVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
            +      + T E  T   ++ LK ++ Y FRL A + +G    +  +   T   +P  P 
Sbjct: 543  HGE--EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP 600

Query: 577  RPLVKGPVTSHGFSVKWDPP---KDNGGSEILKYLLEIT--DGNSEANQWEVAYSGSATE 631
            + +     +S    V W PP   K NG   I +Y ++ T  DG  +     +      T+
Sbjct: 601  QDISCTSPSSTSILVSWQPPPVEKQNG--IITEYSIKYTAVDGEDDKPHEILGIPSDTTK 658

Query: 632  YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVH 689
            Y    L+  T Y++     +  G    S S+ +RT    P    PPR +         V 
Sbjct: 659  YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG--PPRKVEVEAVNSTSVK 716

Query: 690  LEWDVPASES------GCEVSEYSVEMTEPE-----------DVASEVYHGPELECTVGN 732
            + W  P          G +V    +E  EP+           D   E     E +  +  
Sbjct: 717  VSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISG 776

Query: 733  LLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS 792
            L P T Y   V A    G G  S    ++T    PG+ +   I+ T     L+ W  P  
Sbjct: 777  LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL-VINHTQMNTALIQWHPPVD 835

Query: 793  SGADISEYRLEWG-EDEESLELI-YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
            +   +  YRL++G +D E L  + +   +  F   D+   A Y  RL A N+ G G   E
Sbjct: 836  TFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EE 893

Query: 851  LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV-LNWEEP--CNNGSEILAYTIDL 907
            +V      S P+ V T       P + + +  ++  V L+W+ P        I  YT+  
Sbjct: 894  MV---KEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 945

Query: 908  GDTSITV---------GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPL 957
             D +I +          +TTM  +  L P+TTY ++++A    G GP+S  ++ +T P+
Sbjct: 946  RDINIPLLPMEQLIVPADTTM-TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1003



 Score =  120 bits (302), Expect = 6e-27
 Identities = 176/783 (22%), Positives = 290/783 (37%), Gaps = 83/783 (10%)

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
            L D+R + +Y     +    +     E ++  T    P+ P  P +   + +S+TL W +
Sbjct: 278  LNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTWDS 332

Query: 402  PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
               N   ++ Y+++         +++    +     +  L P   Y FR+ A N+IG   
Sbjct: 333  --GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGP 390

Query: 462  YSQEVVCYTLGNIPQMPSAPRLVRAGI---TWVTLQWSKPE---GCSPEEVITYTLEIQE 515
             S+ V+  T    P   SAPR V+A +   T + +QW +PE   G      + YT++  +
Sbjct: 391  PSEPVLTQTSEQAPS--SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 448

Query: 516  DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP 575
              N+ + H     +    T+ NL     Y  ++ A  + G    S  +   T    PG P
Sbjct: 449  HVNNWMKHN--VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 506

Query: 576  TRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 635
                 + P +     + W PP+ +    I  Y L   DG     Q      G  T Y   
Sbjct: 507  LNFKAE-PESETSILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPG--TSYRLQ 560

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKHKEVHLEWD 693
             LKP +LY  R    S  G    +  +  RT+   P    PP+ +    P    + + W 
Sbjct: 561  GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQ 618

Query: 694  VPASES-GCEVSEYSVEMTE---PEDVASEVYHGPE--LECTVGNLLPGTVYRFRVRALN 747
             P  E     ++EYS++ T     +D   E+   P    +  +  L   T YR  V A  
Sbjct: 619  PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 678

Query: 748  DGGYGPYSDVSEITT----AAGPPGQCKAPCISCTPDGCVLVGWESPDSS-------GAD 796
            D G GP S    I T     +GPP + +   ++ T    V V W SP  +       G  
Sbjct: 679  DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS---VKVSWRSPVPNKQHGQIRGYQ 735

Query: 797  ISEYRLEWGEDE-ESLELIYHGTDTRFEIRD----------LLPAAQYCCRLQAFNQAGA 845
            +   R+E GE + + +       D ++E  D          L P   Y   + A+   G 
Sbjct: 736  VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGD 795

Query: 846  GPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI 905
            G  S+          P  VST   +  +P      +     ++ W  P +    +  Y +
Sbjct: 796  GARSK----------PKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRL 845

Query: 906  DLGD------TSITVGNTTMH-VMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP-- 956
              G       T++       H    D+    +Y  R+ A N++G G   + +K  + P  
Sbjct: 846  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEE 903

Query: 957  LPP-LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR---GPS 1012
            +P   P  L        S++L W              YTL   D N   + + +      
Sbjct: 904  VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 963

Query: 1013 HTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEI 1072
             T  +  L   T Y  +++A +  G GP+S +  F T        K   V  +   S  +
Sbjct: 964  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLL 1023

Query: 1073 LWE 1075
             WE
Sbjct: 1024 SWE 1026



 Score =  118 bits (295), Expect = 4e-26
 Identities = 174/767 (22%), Positives = 298/767 (38%), Gaps = 135/767 (17%)

Query: 457  IGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
            + T G  + +   T+  +P+ P  P +  +  T +TL W   +  +PE V  Y ++ +  
Sbjct: 292  MSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTW---DSGNPEPVSYYIIQHKPK 348

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPT 576
             ++ L+           +V  L   + Y+FR+ A N  G+  PSE ++  TS   P    
Sbjct: 349  NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 408

Query: 577  RPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFT 635
            R +    ++S    V+W  P++  G +I  Y +  T D     N W       +   T  
Sbjct: 409  RDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467

Query: 636  HLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHK-EVHLEWDV 694
            +L P   Y ++    ++ G    S  + V T +  PGQ  P      P+ +  + L W  
Sbjct: 468  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTP 525

Query: 695  PASESGCEVSEYSVEMTEPEDVASEVYHGPELECTV--------GNLLPGTVYRFRVRAL 746
            P S++   ++ Y +   + E       HG E   T+          L P ++Y FR+ A 
Sbjct: 526  PRSDT---IANYELVYKDGE-------HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAAR 575

Query: 747  NDGGYG-PYSDVSEITTAAGPPGQCKAPCISCTPDG--CVLVGWESP--DSSGADISEYR 801
            +  G G   +++S  T  + P        ISCT      +LV W+ P  +     I+EY 
Sbjct: 576  SPQGLGASTAEISARTMQSKP--SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYS 633

Query: 802  LEW----GEDEESLELIYHGTD-TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT 856
            +++    GED++  E++   +D T++ +  L    +Y   + A    G GP S  VL +T
Sbjct: 634  IKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRT 693

Query: 857  ----PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNN--GSEILAYTID---- 906
                P+  P  V    V             S  + ++W  P  N    +I  Y +     
Sbjct: 694  NEDVPSGPPRKVEVEAV------------NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRM 741

Query: 907  ---------------LGDTSITVGNTTMH--VMKDLLPETTYRIRIQAINEIGAGPFSQF 949
                           L D      +TT H  ++  L PET+Y + + A    G G  S+ 
Sbjct: 742  ENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKP 801

Query: 950  IKAKTRPLPPLPPRL----------------ECAAAGP-QSLKLKWGDSNSKTHAAEDIV 992
                T    P  PRL                     GP Q  +LK+G  + +       +
Sbjct: 802  KLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEP------L 855

Query: 993  YTLQLEDRNKRFIS--IYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT 1050
             TL+  ++   F +  I++G S             Y FR+ A ++ G G        S  
Sbjct: 856  TTLEFSEKEDHFTATDIHKGAS-------------YVFRLSARNKVGFGE-EMVKEISIP 901

Query: 1051 KSVPPTIKAPRVTQLEG---NSCEILWETVPSMKGDPVNYILQ-VLVGRESE-----YKQ 1101
            + VP     P+    EG    S ++ W+  P +  +    I +  L+ R+        +Q
Sbjct: 902  EEVPTGF--PQNLHSEGTTSTSVQLSWQ--PPVLAERNGIITKYTLLYRDINIPLLPMEQ 957

Query: 1102 VYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSAAF 1148
            +    + T  ++GL+ +T Y  +V A       + +  G +SPS  F
Sbjct: 958  LIVPADTTMTLTGLKPDTTYDVKVRA------HTSKGPGPYSPSVQF 998


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  135 bits (339), Expect = 3e-31
 Identities = 170/723 (23%), Positives = 280/723 (38%), Gaps = 90/723 (12%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVA-LSDKGRDGKYKIIYSGEELEC 340
            P V+   A ++ ++W           SG   P SY V     K +DG Y+I         
Sbjct: 325  PMVTENTATSITITW----------DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 374

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAP-ECPFPPKLAHRSKSSLTLQW 399
            ++  L P ++Y + V A+ +  +G  SE V   T   AP   P   +    S +++ +QW
Sbjct: 375  SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 434

Query: 400  KAPIDNGSKITNYLLEWD-EGKRNSGFRQCFFGSQKHCKLTKLCPAMG-------YTFRL 451
            + P++    I  Y + +  E +   G        QKH     L   +G       YT R+
Sbjct: 435  EEPVEPNGLIRGYRVYYTMEPEHPVG------NWQKHNVDDSLLTTVGSLLEDETYTVRV 488

Query: 452  AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
             A   +G    S  +   T   +P  P   R      T +TL WS P     E +I Y L
Sbjct: 489  LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYEL 545

Query: 512  EIQEDENDNLFHPKYTGEDLTCT----VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
              +E +     H +  G     T    V++LK +T+Y FRL A + +G    + V+   T
Sbjct: 546  LFREGD-----HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600

Query: 568  SPDRPGPPTRPLVKGPVTSHGFSVKW-DPPKDNGGSEILKYLLEITD-GNSEANQWEV-A 624
               +P  P + +    V S    V W  PP +     ++ Y +     G+ +    EV  
Sbjct: 601  LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG 660

Query: 625  YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP- 683
               + T+     L+  T Y++     +  G    S  + VRT    P    PPR +    
Sbjct: 661  IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS--APPRKVEAEA 718

Query: 684  -KHKEVHLEWDVPA-SESGCEVSEYSVEMTEPEDVAS-------EVYHGPELECTVGNLL 734
                 + + W  PA      ++  Y V     E   +       +V      E  + NL 
Sbjct: 719  LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQ 778

Query: 735  PGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISC--TPDGCVLVGWESPDS 792
            P T Y   V A    G G  S    + T     G+   P +S   TP+G +L  WE P  
Sbjct: 779  PETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGR---PTLSVQQTPEGSLLARWEPPAG 835

Query: 793  SGAD-ISEYRLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
            +  D +  YRL++G ++ +    L +  ++ R+    +   A Y  RL A ++ G G  +
Sbjct: 836  TAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEA 895

Query: 850  ELVLC---QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW--EEPCNNGSEILAYT 904
              VL     TP   P           + L+A  ++ +  ++L W    P      I+ YT
Sbjct: 896  AEVLSIPEDTPRGHP-----------QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 944

Query: 905  IDLGD-------------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIK 951
            + + +              +   G      ++ L P+T Y ++++A    G GPFS  ++
Sbjct: 945  VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1004

Query: 952  AKT 954
             +T
Sbjct: 1005 YRT 1007



 Score =  108 bits (271), Expect = 2e-23
 Identities = 174/736 (23%), Positives = 272/736 (36%), Gaps = 83/736 (11%)

Query: 461  GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
            G  + V   T+ ++P+ P  P +     T +T+ W   +  +P+ V  Y +E +    D 
Sbjct: 305  GVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSKSQDG 361

Query: 521  LFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTR 577
             +  K   ED+T T   +  L  +++Y+  ++A N+ G+  PSE +V  T    P    R
Sbjct: 362  PYQIK---EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPR 418

Query: 578  PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFTH 636
             +    +++    V+W+ P +  G  I  Y +  T +       W+      +   T   
Sbjct: 419  NVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477

Query: 637  LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPA 696
            L     Y +R    ++ G    S+ + V+T    PGQ    R   R     + L W  P 
Sbjct: 478  LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPR 536

Query: 697  SESGCEVSEYSVEMTEPEDVASEV--YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPY 754
             ES   + +Y +   E  D   EV     P     V +L P T Y FR+ A +  G G +
Sbjct: 537  QES---IIKYELLFRE-GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAF 592

Query: 755  SDVSEITT----AAGPPGQCKAPCISCTPDGCVLVGWESP---DSSGADIS---EYRLEW 804
            + V    T     + PP   K   +  T    +LV W  P     +GA +     YR   
Sbjct: 593  TPVVRQRTLQSKPSAPPQDVKCVSVRST---AILVSWRPPPPETHNGALVGYSVRYRPLG 649

Query: 805  GEDEESLELI-YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDP 863
             ED E  E+     T T+  +  L    QY     A  + G GP S  V+ +T    P  
Sbjct: 650  SEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSA 709

Query: 864  VSTLCVLEEEPLDAYPDSPSACLVLNWEEPC--NNGSEILAYTIDL------------GD 909
                  +E E L+A     +A  VL W  P       +I  Y +                
Sbjct: 710  PPR--KVEAEALNA-----TAIRVL-WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 761

Query: 910  TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAA 969
              + + +    V+ +L PET Y I + A    G G  S+     T+      P L     
Sbjct: 762  KDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT 821

Query: 970  GPQSLKLKWGDSNSKTHAAEDIV--YTLQL--EDRNKRFISIYRGPSHTYKVQRLTEFTC 1025
               SL  +W         AED V  Y LQ   ED        +      Y    + +   
Sbjct: 822  PEGSLLARW---EPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 878

Query: 1026 YSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC--EILWETVPSMKGD 1083
            Y FR+ A S  G G        S  +  P     P++ +  GN+    +L   +P +  +
Sbjct: 879  YVFRLAARSRGGLGE-EAAEVLSIPEDTPR--GHPQILEAAGNASAGTVLLRWLPPVPAE 935

Query: 1084 PVNYILQVLV----------GRESEYKQVYK-GEEATFQISGLQTNTDYRFRVCACRRCL 1132
                I++  V           RE+E     + G E    + GL+ +T Y  +V A  R  
Sbjct: 936  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTR-- 993

Query: 1133 DTSQELSGAFSPSAAF 1148
                   G FSP   +
Sbjct: 994  ----RGPGPFSPPVRY 1005



 Score =  105 bits (261), Expect = 3e-22
 Identities = 164/722 (22%), Positives = 268/722 (37%), Gaps = 86/722 (11%)

Query: 264  EYELEVKRVQDILSGIEKPQV-------------SNIQAR-----AVVLSWAPPVGLSCG 305
            EYE+ V  V  I  G     V              N+QAR      +++ W  PV     
Sbjct: 384  EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV----- 438

Query: 306  PHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGS 365
              +GL   Y     +  +   G ++     + L   +  L     Y VRV A  +   G 
Sbjct: 439  EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498

Query: 366  CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGF 425
             S+P+   T    P  P   +   RS++S+TL W  P      I  Y L + EG      
Sbjct: 499  LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKYELLFREGDHGREV 556

Query: 426  RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLV 484
             + F  +  +  +  L P   Y FRLAAR+  G   ++  V   TL + P  P    + V
Sbjct: 557  GRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615

Query: 485  RAGITWVTLQWSKPEGCSPE----EVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKN 537
                T + + W  P    PE     ++ Y++  +   +++    +  G   T T   ++ 
Sbjct: 616  SVRSTAILVSWRPP---PPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEA 672

Query: 538  LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPP- 596
            L++ TQY+    A    G    S  +V  T  D P  P R +    + +    V W  P 
Sbjct: 673  LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPA 732

Query: 597  --KDNG---GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
              + +G   G ++    +E  +        +V  +  A E   T+L+P T Y +     +
Sbjct: 733  PGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA-DAQEMVITNLQPETAYSITVAAYT 791

Query: 652  TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
              G    S+   V T     G  RP   + +     +   W+ PA  +  +V  Y ++  
Sbjct: 792  MKGDGARSKPKVVVTKGAVLG--RPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFG 849

Query: 712  EPEDVASEVYHGPELE--CTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEI-----TTAA 764
              +         P  E   T   +  G  Y FR+ A + GG G   + +E+      T  
Sbjct: 850  REDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG--EEAAEVLSIPEDTPR 907

Query: 765  GPPGQCKAPCISCTPDGCVLVGWESP---DSSGADISEYRLEWGE--------DEESLEL 813
            G P   +A        G VL+ W  P   + +GA I +Y +   E        + E    
Sbjct: 908  GHPQILEA--AGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARETELPAA 964

Query: 814  IYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT---PASAPDPVSTLCVL 870
               G +    ++ L P   Y  +++A  + G GP+S  V  +T      +P       ++
Sbjct: 965  AEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIM 1024

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV-GNTTMHVMKDLLPET 929
            +              ++L+WE P N  S    Y I     ++ V G TT  ++  L P T
Sbjct: 1025 K------------TSVLLSWEFPDNYNSP-TPYKIQYNGLTLDVDGRTTKKLITHLKPHT 1071

Query: 930  TY 931
             Y
Sbjct: 1072 FY 1073



 Score =  101 bits (252), Expect = 4e-21
 Identities = 165/769 (21%), Positives = 277/769 (36%), Gaps = 75/769 (9%)

Query: 368  EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
            E V+  T    P+ P  P +   + +S+T+ W +   N   ++ Y++E+    ++  ++ 
Sbjct: 308  EAVAQITVKSLPKAPGTPMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQI 365

Query: 428  CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAG 487
                +     +  L P   Y   ++A N IG    S+ VV  T    P   SAPR V+A 
Sbjct: 366  KEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--SAPRNVQAR 423

Query: 488  I---TWVTLQWSKP---EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
            +   T + +QW +P    G      + YT+E +    +   H     + L  TV +L   
Sbjct: 424  MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN--VDDSLLTTVGSLLED 481

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
              Y  R+ A  + G    S+ +   T    PG P     +   +    ++ W PP+    
Sbjct: 482  ETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPRQES- 539

Query: 602  SEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
              I+KY L   +G+      EV  +    T Y    LKP T Y  R    S  G    + 
Sbjct: 540  --IIKYELLFREGDHGR---EVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 594

Query: 661  SLPVRTLSIAPGQCRPPRVLG--RPKHKEVHLEWDVPASES------GCEVSEYSVEMTE 712
             +  RTL   P    PP+ +     +   + + W  P  E+      G  V    +   +
Sbjct: 595  VVRQRTLQSKPSA--PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSED 652

Query: 713  PEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT----AAGPPG 768
            PE            +  +  L   T YR    A  + G GP S    + T     + PP 
Sbjct: 653  PEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPR 712

Query: 769  QCKAPCISCTPDGCVLVGWESPDSS-------GADISEYRLEWGEDE--ESLELIYHGTD 819
            + +A  ++ T    + V W SP          G  +   R+E  E      ++ +     
Sbjct: 713  KVEAEALNAT---AIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADA 769

Query: 820  TRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYP 879
                I +L P   Y   + A+   G G  S+          P  V T   +   P  +  
Sbjct: 770  QEMVITNLQPETAYSITVAAYTMKGDGARSK----------PKVVVTKGAVLGRPTLSVQ 819

Query: 880  DSPSACLVLNWEEPCNNGSE-ILAYTIDLGDTSITVGNTT-------MHVMKDLLPETTY 931
             +P   L+  WE P     + +L Y +  G    T   T         +    +    TY
Sbjct: 820  QTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATY 879

Query: 932  RIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAA--AGPQSLKLKWGDSNSKTHAAE 989
              R+ A +  G G  +  + +     P   P++  AA  A   ++ L+W           
Sbjct: 880  VFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGA 939

Query: 990  DIVYTLQLED--------RNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPF 1041
             + YT+ + +          +   +   G  +   +Q L   T Y  +++A +  G GPF
Sbjct: 940  IVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPF 999

Query: 1042 SETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQ 1090
            S    + T      + K  +V  +   S  + WE  P     P  Y +Q
Sbjct: 1000 SPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWE-FPDNYNSPTPYKIQ 1047


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  134 bits (337), Expect = 5e-31
 Identities = 172/732 (23%), Positives = 280/732 (38%), Gaps = 99/732 (13%)

Query: 282  PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVA-LSDKGRDGKYKIIYSGEELEC 340
            P V+   A ++ ++W           SG   P SY V     K +DG Y+I         
Sbjct: 338  PMVTENTATSITITW----------DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 387

Query: 341  NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAP-ECPFPPKLAHRSKSSLTLQW 399
            ++  L P ++Y + V A+ +  +G  SE V   T   AP   P   +    S +++ +QW
Sbjct: 388  SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 447

Query: 400  KAPIDNGSKITNYLLEWD-EGKRNSGFRQCFFGSQKHCKLTKLCPAMG-------YTFRL 451
            + P++    I  Y + +  E +   G        QKH     L   +G       YT R+
Sbjct: 448  EEPVEPNGLIRGYRVYYTMEPEHPVG------NWQKHNVDDSLLTTVGSLLEDETYTVRV 501

Query: 452  AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
             A   +G    S  +   T   +P  P   R      T +TL WS P     E +I Y L
Sbjct: 502  LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYEL 558

Query: 512  EIQEDENDNLFHPKYTGEDLTCT----VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
              +E +     H +  G     T    V++LK +T+Y FRL A + +G    + V+   T
Sbjct: 559  LFREGD-----HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 613

Query: 568  SPDRPGPPTRPLVKGPVTSHGFSVKW-DPPKDNGGSEILKYLLEITD-GNSEANQWEV-A 624
               +P  P + +    V S    V W  PP +     ++ Y +     G+ +    EV  
Sbjct: 614  LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG 673

Query: 625  YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRP- 683
               + T+     L+  T Y++     +  G    S  + VRT    P    PPR +    
Sbjct: 674  IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS--APPRKVEAEA 731

Query: 684  -KHKEVHLEWDVPA-SESGCEVSEYSVEMTEPE----------------DVASEVYHGPE 725
                 + + W  PA      ++  Y V     E                D   E     E
Sbjct: 732  LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791

Query: 726  LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISC--TPDGCV 783
             E  + NL P T Y   V A    G G  S    + T     G+   P +S   TP+G +
Sbjct: 792  YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGR---PTLSVQQTPEGSL 848

Query: 784  LVGWESPDSSGAD-ISEYRLEWGEDEES--LELIYHGTDTRFEIRDLLPAAQYCCRLQAF 840
            L  WE P  +  D +  YRL++G ++ +    L +  ++ R+    +   A Y  RL A 
Sbjct: 849  LARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAAR 908

Query: 841  NQAGAGPYSELVLC---QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW--EEPCN 895
            ++ G G  +  VL     TP   P           + L+A  ++ +  ++L W    P  
Sbjct: 909  SRGGLGEEAAEVLSIPEDTPRGHP-----------QILEAAGNASAGTVLLRWLPPVPAE 957

Query: 896  NGSEILAYTIDLGD-------------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
                I+ YT+ + +              +   G      ++ L P+T Y ++++A    G
Sbjct: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG 1017

Query: 943  AGPFSQFIKAKT 954
             GPFS  ++ +T
Sbjct: 1018 PGPFSPPVRYRT 1029



 Score =  108 bits (270), Expect = 3e-23
 Identities = 177/745 (23%), Positives = 274/745 (36%), Gaps = 92/745 (12%)

Query: 461  GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
            G  + V   T+ ++P+ P  P +     T +T+ W   +  +P+ V  Y +E +    D 
Sbjct: 318  GVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSKSQDG 374

Query: 521  LFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTR 577
             +  K   ED+T T   +  L  +++Y+  ++A N+ G+  PSE +V  T    P    R
Sbjct: 375  PYQIK---EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPR 431

Query: 578  PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFTH 636
             +    +++    V+W+ P +  G  I  Y +  T +       W+      +   T   
Sbjct: 432  NVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 490

Query: 637  LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPA 696
            L     Y +R    ++ G    S+ + V+T    PGQ    R   R     + L W  P 
Sbjct: 491  LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPR 549

Query: 697  SESGCEVSEYSVEMTEPEDVASEV--YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPY 754
             ES   + +Y +   E  D   EV     P     V +L P T Y FR+ A +  G G +
Sbjct: 550  QES---IIKYELLFRE-GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAF 605

Query: 755  SDVSEITT----AAGPPGQCKAPCISCTPDGCVLVGWESP---DSSGADIS---EYRLEW 804
            + V    T     + PP   K   +  T    +LV W  P     +GA +     YR   
Sbjct: 606  TPVVRQRTLQSKPSAPPQDVKCVSVRST---AILVSWRPPPPETHNGALVGYSVRYRPLG 662

Query: 805  GEDEESLELI-YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDP 863
             ED E  E+     T T+  +  L    QY     A  + G GP S  V+ +T    P  
Sbjct: 663  SEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSA 722

Query: 864  VSTLCVLEEEPLDAYPDSPSACLVLNWEEPC--NNGSEILAYTID--------------- 906
                  +E E L+A     +A  VL W  P       +I  Y +                
Sbjct: 723  PPR--KVEAEALNA-----TAIRVL-WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 774

Query: 907  ----LGDTSITVGNTTMH--VMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960
                L D      +T  +  V+ +L PET Y I + A    G G  S+     T+     
Sbjct: 775  KDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLG 834

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV--YTLQL--EDRNKRFISIYRGPSHTYK 1016
             P L        SL  +W         AED V  Y LQ   ED        +      Y 
Sbjct: 835  RPTLSVQQTPEGSLLARW---EPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYT 891

Query: 1017 VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC--EILW 1074
               + +   Y FR+ A S  G G        S  +  P     P++ +  GN+    +L 
Sbjct: 892  ASGVHKGATYVFRLAARSRGGLGE-EAAEVLSIPEDTPR--GHPQILEAAGNASAGTVLL 948

Query: 1075 ETVPSMKGDPVNYILQVLV----------GRESEYKQVYK-GEEATFQISGLQTNTDYRF 1123
              +P +  +    I++  V           RE+E     + G E    + GL+ +T Y  
Sbjct: 949  RWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDL 1008

Query: 1124 RVCACRRCLDTSQELSGAFSPSAAF 1148
            +V A  R         G FSP   +
Sbjct: 1009 QVRAHTR------RGPGPFSPPVRY 1027



 Score =  102 bits (255), Expect = 2e-21
 Identities = 167/731 (22%), Positives = 269/731 (36%), Gaps = 95/731 (12%)

Query: 264  EYELEVKRVQDILSGIEKPQV-------------SNIQAR-----AVVLSWAPPVGLSCG 305
            EYE+ V  V  I  G     V              N+QAR      +++ W  PV     
Sbjct: 397  EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV----- 451

Query: 306  PHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGS 365
              +GL   Y     +  +   G ++     + L   +  L     Y VRV A  +   G 
Sbjct: 452  EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 511

Query: 366  CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGF 425
             S+P+   T    P  P   +   RS++S+TL W  P      I  Y L + EG      
Sbjct: 512  LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKYELLFREGDHGREV 569

Query: 426  RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLV 484
             + F  +  +  +  L P   Y FRLAAR+  G   ++  V   TL + P  P    + V
Sbjct: 570  GRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628

Query: 485  RAGITWVTLQWSKPEGCSPE----EVITYTLEIQEDENDNLFHPKYTGEDLTCT---VKN 537
                T + + W  P    PE     ++ Y++  +   +++    +  G   T T   ++ 
Sbjct: 629  SVRSTAILVSWRPP---PPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEA 685

Query: 538  LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPP- 596
            L++ TQY+    A    G    S  +V  T  D P  P R +    + +    V W  P 
Sbjct: 686  LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPA 745

Query: 597  --KDNG---GSEILKYLLE---------ITDGNSEANQWEVAYSGSATEYTFTHLKPGTL 642
              + +G   G ++    +E         I D      QWE     +  E   T+L+P T 
Sbjct: 746  PGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETD-DTAEYEMVITNLQPETA 804

Query: 643  YKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCE 702
            Y +     +  G    S+   V T     G  RP   + +     +   W+ PA  +  +
Sbjct: 805  YSITVAAYTMKGDGARSKPKVVVTKGAVLG--RPTLSVQQTPEGSLLARWEPPAGTAEDQ 862

Query: 703  VSEYSVEMTEPEDVASEVYHGPELE--CTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEI 760
            V  Y ++    +         P  E   T   +  G  Y FR+ A + GG G   + +E+
Sbjct: 863  VLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG--EEAAEV 920

Query: 761  -----TTAAGPPGQCKAPCISCTPDGCVLVGWESP---DSSGADISEYRLEWGE------ 806
                  T  G P   +A        G VL+ W  P   + +GA I +Y +   E      
Sbjct: 921  LSIPEDTPRGHPQILEA--AGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGP 977

Query: 807  --DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT---PASAP 861
              + E       G +    ++ L P   Y  +++A  + G GP+S  V  +T      +P
Sbjct: 978  ARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSP 1037

Query: 862  DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV-GNTTMH 920
                   +++              ++L+WE P N  S    Y I     ++ V G TT  
Sbjct: 1038 KNFKVKMIMK------------TSVLLSWEFPDNYNSP-TPYKIQYNGLTLDVDGRTTKK 1084

Query: 921  VMKDLLPETTY 931
            ++  L P T Y
Sbjct: 1085 LITHLKPHTFY 1095



 Score =  100 bits (249), Expect = 8e-21
 Identities = 168/778 (21%), Positives = 279/778 (35%), Gaps = 84/778 (10%)

Query: 368  EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
            E V+  T    P+ P  P +   + +S+T+ W +   N   ++ Y++E+    ++  ++ 
Sbjct: 321  EAVAQITVKSLPKAPGTPMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQI 378

Query: 428  CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAG 487
                +     +  L P   Y   ++A N IG    S+ VV  T    P   SAPR V+A 
Sbjct: 379  KEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--SAPRNVQAR 436

Query: 488  I---TWVTLQWSKP---EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
            +   T + +QW +P    G      + YT+E +    +   H     + L  TV +L   
Sbjct: 437  MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHN--VDDSLLTTVGSLLED 494

Query: 542  TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
              Y  R+ A  + G    S+ +   T    PG P     +   +    ++ W PP+    
Sbjct: 495  ETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPRQES- 552

Query: 602  SEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
              I+KY L   +G+      EV  +    T Y    LKP T Y  R    S  G    + 
Sbjct: 553  --IIKYELLFREGDHGR---EVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 607

Query: 661  SLPVRTLSIAPGQCRPPRVLG--RPKHKEVHLEWDVPASES------GCEVSEYSVEMTE 712
             +  RTL   P    PP+ +     +   + + W  P  E+      G  V    +   +
Sbjct: 608  VVRQRTLQSKPSA--PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSED 665

Query: 713  PEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT----AAGPPG 768
            PE            +  +  L   T YR    A  + G GP S    + T     + PP 
Sbjct: 666  PEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPR 725

Query: 769  QCKAPCISCTPDGCVLVGWESPDSS-------GADISEYRLEWGE--------DEESLEL 813
            + +A  ++ T    + V W SP          G  +   R+E  E        D    + 
Sbjct: 726  KVEAEALNAT---AIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADA 782

Query: 814  IYHGTDT---RFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVL 870
             +   DT      I +L P   Y   + A+   G G  S+          P  V T   +
Sbjct: 783  QWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK----------PKVVVTKGAV 832

Query: 871  EEEPLDAYPDSPSACLVLNWEEPCNNGSE-ILAYTIDLGDTSITVGNTT-------MHVM 922
               P  +   +P   L+  WE P     + +L Y +  G    T   T         +  
Sbjct: 833  LGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTA 892

Query: 923  KDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAA--AGPQSLKLKWGD 980
              +    TY  R+ A +  G G  +  + +     P   P++  AA  A   ++ L+W  
Sbjct: 893  SGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLP 952

Query: 981  SNSKTHAAEDIVYTLQLED--------RNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
                      + YT+ + +          +   +   G  +   +Q L   T Y  +++A
Sbjct: 953  PVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRA 1012

Query: 1033 ASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQ 1090
             +  G GPFS    + T      + K  +V  +   S  + WE  P     P  Y +Q
Sbjct: 1013 HTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWE-FPDNYNSPTPYKIQ 1069


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  129 bits (325), Expect = 1e-29
 Identities = 156/660 (23%), Positives = 258/660 (39%), Gaps = 69/660 (10%)

Query: 449  FRLAARNDIGTSGYSQEVVC--YTLGNIPQMPSAPRLVRAGIT---WVTLQW----SKPE 499
            ++  A ND+G +    +++   +       +PSAPR V A +    ++ L W    S P 
Sbjct: 408  YQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467

Query: 500  GCSPEEVITYTLE-IQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
            G +    + YT E I  +  +N  HP     ++  T++NL  +T Y FR+ A N  G   
Sbjct: 468  GDNLTYSVFYTKEGIARERVENTSHPG----EMQVTIQNLMPATVYIFRVMAQNKHGSGE 523

Query: 559  PSEVLVCTTSPD----RPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDG 614
             S  L   T P+     P P  R     P +    +V W+ P  +G  EI  Y L   + 
Sbjct: 524  SSAPLRVETQPEVQLPGPAPNLRAYAASPTS---ITVTWETPV-SGNGEIQNYKLYYMEK 579

Query: 615  NSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQC 674
             ++  Q       S+  YT   LK  T Y  R    +  G    +  + VRTLS  P   
Sbjct: 580  GTDKEQ---DVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAA 636

Query: 675  RPPRVLGRPKHKEVHLEWD--VPASESGCEVSEYSV---EMTEPEDVASEVYHGPELECT 729
                 L     K + + W    PA+++G +++ Y +   + +   DV   +  G +L   
Sbjct: 637  PQNLSLEVRNSKSIMIHWQPPAPATQNG-QITGYKIRYRKASRKSDVTETLVSGTQLSQL 695

Query: 730  VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD-----GCVL 784
            +  L  GT Y FRV AL   G GP +D     T      + + P +  +         ++
Sbjct: 696  IEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIV 755

Query: 785  VGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRF-EIRDLLPAAQYCCRLQAFNQA 843
            V W  P++    +  Y + +G      + I      R+  I +L P++ Y   L+AFN  
Sbjct: 756  VSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNV 815

Query: 844  GAG----------PYSE-----LVLCQTPAS-APDPVSTLCVLEEEPLDAYPDSPSACLV 887
            G G          P+++     L +   P +  PDP   +  +  +      D+      
Sbjct: 816  GEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWA 875

Query: 888  LNWEEPCNNGSEILAYTIDL-----GDTSITVGNTTM--HVMKDLLPETTYRIRIQAINE 940
             N        ++   YT+        +T     N T   +++  L P T Y   +     
Sbjct: 876  DNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKG 935

Query: 941  IGAGPFSQFIKAKTRPLPPLPPRLECAAAG----PQSLKLKW---GDSNSKTHAAEDIVY 993
              +  +S      T  L P  P  +         P+++ + W    ++N K      I Y
Sbjct: 936  RRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKI-TGYIIYY 994

Query: 994  TLQLE-DRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS 1052
            +  +  + +   I    G   T+++Q LT  T Y F+IQA +  G GP SE   F T K+
Sbjct: 995  STDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA 1054



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/622 (22%), Positives = 232/622 (37%), Gaps = 66/622 (10%)

Query: 285  SNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKD 344
            S +  R + L+W  P      PH G +  YS         R+      + GE ++  +++
Sbjct: 448  SLVSTRFIKLTWRTPAS---DPH-GDNLTYSVFYTKEGIARERVENTSHPGE-MQVTIQN 502

Query: 345  LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFP---PKLAH--RSKSSLTLQW 399
            L PAT Y  RV A      G  S P+   T    PE   P   P L     S +S+T+ W
Sbjct: 503  LMPATVYIFRVMAQNKHGSGESSAPLRVETQ---PEVQLPGPAPNLRAYAASPTSITVTW 559

Query: 400  KAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
            + P+    +I NY L + E  + +   Q    S     +  L     Y+FR+ A N  G 
Sbjct: 560  ETPVSGNGEIQNYKLYYME--KGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGP 617

Query: 460  SGYSQEVVCYTLGNIPQ-MPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT-YTLEIQE-D 516
               + +V   TL ++P   P    L       + + W  P   +    IT Y +  ++  
Sbjct: 618  GVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKAS 677

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDR----- 571
               ++     +G  L+  ++ L R T+Y FR+ A    G    ++ L   T         
Sbjct: 678  RKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETR 737

Query: 572  -PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSAT 630
             P  P+   V+  VTS    V W PP +N    +  Y +    G+  A   +V Y     
Sbjct: 738  VPEVPSSLHVRPLVTS--IVVSWTPP-ENQNIVVRGYAIGYGIGSPHAQTIKVDY--KQR 792

Query: 631  EYTFTHLKPGTLYKLRACCISTGG-------------HSQCSE------SLPVRTLSIAP 671
             YT  +L P + Y +     +  G             H+  SE      + P   +   P
Sbjct: 793  YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVP-DP 851

Query: 672  GQCRPPRVLGRP--KHKEVHLEW---DVPASESGCEVSEYSV--EMTEPEDVASEVYHGP 724
                PP  +      H  + + W    +P  +   +   Y+V  +   P +   +  +  
Sbjct: 852  TPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANAT 911

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDG--- 781
             L   V  L P T+Y F V          +S  +  TT    P          + +G   
Sbjct: 912  TLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPK 971

Query: 782  CVLVGWESPDSSGADISEYRLEWGEDEES------LELIYHGTDTRFEIRDLLPAAQYCC 835
             ++V W+ P  +   I+ Y + +  D  +      +E +  G     +I++L     Y  
Sbjct: 972  TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVV-GNRLTHQIQELTLDTPYYF 1030

Query: 836  RLQAFNQAGAGPYSELVLCQTP 857
            ++QA N  G GP SE V  +TP
Sbjct: 1031 KIQARNSKGMGPMSEAVQFRTP 1052



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 136/622 (21%), Positives = 225/622 (36%), Gaps = 87/622 (13%)

Query: 395  LTLQWKAPIDN--GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLA 452
            + L W+ P  +  G  +T  +    EG             +    +  L PA  Y FR+ 
Sbjct: 455  IKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVM 514

Query: 453  ARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL--VRAGITWVTLQWSKPEGCSPEEVITYT 510
            A+N  G+   S  +   T   +     AP L    A  T +T+ W  P   + E +  Y 
Sbjct: 515  AQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGE-IQNYK 573

Query: 511  LEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
            L   E   D       +    T  +  LK+ T+Y FR+ A N  G    +  +   T  D
Sbjct: 574  LYYMEKGTDKEQDVDVSSHSYT--INGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSD 631

Query: 571  RPGPPTRPLVKGPVTSHGFSVKWDPPKD-NGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
             P    + L      S    + W PP       +I  Y +     + +++  E   SG+ 
Sbjct: 632  VPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQ 691

Query: 630  TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG----RPKH 685
                   L  GT Y  R   ++  G    ++ L   T      + R P V      RP  
Sbjct: 692  LSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLV 751

Query: 686  KEVHLEWDVPASESGCEVSEYSVE--MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRV 743
              + + W  P +++   V  Y++   +  P     +V +  +   T+ NL P + Y   +
Sbjct: 752  TSIVVSWTPPENQN-IVVRGYAIGYGIGSPHAQTIKVDY-KQRYYTIENLDPSSHYVITL 809

Query: 744  RALNDGGYG----------PYSDVSEIT--------------TAAGPPGQCKAPCISCTP 779
            +A N+ G G          P++D SE+               T   PP   +A  +S   
Sbjct: 810  KAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILS--- 866

Query: 780  DGCVLVGWESPD----SSGADISEYRLEWG---------EDEESLELIYHGT----DTRF 822
               + + W            D   Y + W          ++  +  L Y  T    +T +
Sbjct: 867  HDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLY 926

Query: 823  EIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP 882
            E   ++   +   R   ++    G   ELV    P S P  V T+   E +P        
Sbjct: 927  EFSVMVTKGR---RSSTWSMTAHGTTFELV----PTSPPKDV-TVVSKEGKP-------- 970

Query: 883  SACLVLNWEEPCNNGSEILAYTI--------DLGDTSI--TVGNTTMHVMKDLLPETTYR 932
               +++NW+ P     +I  Y I        ++ D  I   VGN   H +++L  +T Y 
Sbjct: 971  -KTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYY 1029

Query: 933  IRIQAINEIGAGPFSQFIKAKT 954
             +IQA N  G GP S+ ++ +T
Sbjct: 1030 FKIQARNSKGMGPMSEAVQFRT 1051



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 76/280 (27%), Positives = 125/280 (44%), Gaps = 31/280 (11%)

Query: 874  PLDAYPDSPSACLV------LNWEEPCNNG-SEILAYTIDLGDTSIT---VGNTT----M 919
            PL + P    A LV      L W  P ++   + L Y++      I    V NT+    M
Sbjct: 437  PLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEM 496

Query: 920  HV-MKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLP---PRLECAAAGPQSLK 975
             V +++L+P T Y  R+ A N+ G+G  S  ++ +T+P   LP   P L   AA P S+ 
Sbjct: 497  QVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSIT 556

Query: 976  LKWGDSNSKTHAAEDI-VYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
            + W    S     ++  +Y ++     ++ + +    SH+Y +  L ++T YSFR+ A +
Sbjct: 557  VTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDV---SSHSYTINGLKKYTEYSFRVVAYN 613

Query: 1035 EAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE---GNSCEILWE--TVPSMKGDPVNYIL 1089
            + G G  +      T   VP    AP+   LE     S  I W+     +  G    Y +
Sbjct: 614  KHGPGVSTPDVAVRTLSDVPSA--APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKI 671

Query: 1090 QV-LVGRESEYKQ-VYKGEEATFQISGLQTNTDYRFRVCA 1127
            +     R+S+  + +  G + +  I GL   T+Y FRV A
Sbjct: 672  RYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 67/295 (22%), Positives = 123/295 (41%), Gaps = 31/295 (10%)

Query: 787  WESP--DSSGADI--SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQ 842
            W +P  D  G ++  S +  + G   E +E   H  + +  I++L+PA  Y  R+ A N+
Sbjct: 459  WRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK 518

Query: 843  AGAGPYSELVLCQTPASA--PDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI 900
             G+G  S  +  +T      P P   L         AY  SP++ + + WE P +   EI
Sbjct: 519  HGSGESSAPLRVETQPEVQLPGPAPNL--------RAYAASPTS-ITVTWETPVSGNGEI 569

Query: 901  LAYTI---DLG-----DTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKA 952
              Y +   + G     D  ++  + T++ +K     T Y  R+ A N+ G G  +  +  
Sbjct: 570  QNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKY---TEYSFRVVAYNKHGPGVSTPDVAV 626

Query: 953  KTRPLPP--LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFI---SI 1007
            +T    P   P  L       +S+ + W      T   +   Y ++    +++     ++
Sbjct: 627  RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL 686

Query: 1008 YRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRV 1062
              G   +  ++ L   T Y+FR+ A +  G GP ++  +  T +S     + P V
Sbjct: 687  VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEV 741



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 49/181 (27%), Positives = 74/181 (40%), Gaps = 7/181 (3%)

Query: 952  AKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHA---AEDIVYTLQLEDRNKRFISIY 1008
            A T PLP  P  +  +    + +KL W    S  H       + YT +   R +   + +
Sbjct: 433  ATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSH 492

Query: 1009 RGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP--RVTQLE 1066
             G      +Q L   T Y FR+ A ++ G G  S      T   V     AP  R     
Sbjct: 493  PGEMQV-TIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAAS 551

Query: 1067 GNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVC 1126
              S  + WET  S  G+  NY L  +  + ++ +Q       ++ I+GL+  T+Y FRV 
Sbjct: 552  PTSITVTWETPVSGNGEIQNYKLYYM-EKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVV 610

Query: 1127 A 1127
            A
Sbjct: 611  A 611


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  128 bits (322), Expect = 3e-29
 Identities = 220/917 (23%), Positives = 352/917 (38%), Gaps = 122/917 (13%)

Query: 289  ARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE-CNLKDLRP 347
            + AVVLSW  P         G S    Y V LS+     K  +   G E+    +  L P
Sbjct: 683  SHAVVLSWVRPF-------DGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTP 735

Query: 348  ATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECP--FPPK---LAHRSKSSLTLQWKAP 402
            A  Y  RV A+    +G  S     T+    PE P   PPK    + R+  S+ +QW+ P
Sbjct: 736  ARTYQFRVCAVNEVGRGQYSAE---TSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPP 792

Query: 403  --IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQK--HCKLTKLCPAMGYTFRLAARNDIG 458
               ++   +  Y+L +        ++Q    S +  +C +T L     Y  ++AA N  G
Sbjct: 793  PETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAG 852

Query: 459  TSGYSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPE-----------------G 500
               +S+ V  YTL  +P  P       A   T +   W+ P                   
Sbjct: 853  LGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA 912

Query: 501  CSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPS 560
             +PE V   T+          FH  + G      + NLK+ T Y   +    T G   PS
Sbjct: 913  DAPEAVTVVTIAPD-------FHGVHHGH-----ITNLKKFTAYFTSVLCFTTPGDGPPS 960

Query: 561  EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQ 620
               +  T  D+PG     L    +      V W  P +  G  I  Y +         ++
Sbjct: 961  TPQLVWTQEDKPGAVGH-LSFTEILDTSLKVSWQEPLEKNGI-ITGYQISWEVYGRNDSR 1018

Query: 621  WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVL 680
                 + +  EY    L   T Y +    ++  G    + S      +I+ G   PP + 
Sbjct: 1019 LTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSS------TISSGV--PPDLP 1070

Query: 681  GRPKH--------KEVHLEWDVPASESGCEVSEYSVE-----MTEPEDVAS--EVYHGPE 725
            G P +        +   L++  P  +    +S + VE     + + E+  +  E  + P+
Sbjct: 1071 GAPSNLVISNISPRSATLQFR-PGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129

Query: 726  LECT-VGNLLPGTVYRFRVRALNDGGYGPYSDVSEI--TTAAGPPGQCKAPCISCTPDGC 782
             +   + NL P T YRFR++ +N  G  PYS  S +  T  A P     +  +    +  
Sbjct: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189

Query: 783  VLVGWES-PDSSGADISE---YRLE-WGEDEES---LELIYHGTDTRFEIRDLLPAAQYC 834
            + + W   PDS      E   YR++ W  D +S    +++    +  F I +L    +Y 
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249

Query: 835  CRLQAFNQAGAGPYSELVLCQT----PASAPDPVSTLCVLEEEPL---DAYPDSPSACLV 887
             ++QAFN  GAGP+SE+V  +T    P++AP+ VS   V   + L    + P+     L+
Sbjct: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309

Query: 888  LNWEEPCNNGSEILAYTIDLGD---TSITVGNTTMH-VMKDLLPETTYRIRIQAINEIGA 943
            L        G +IL    DL     + I  GN T   ++  L     Y +++ A   IG 
Sbjct: 1310 L--------GYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGN 1361

Query: 944  G-PFSQFIKAKTRPLPPLPP-RLECAAAGPQSLKLKW--GDSNSKTHAAEDIVYTLQLED 999
            G P +  I  +T+   P PP RL        S+++ W   +  +       I Y L    
Sbjct: 1362 GVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSS 1421

Query: 1000 RNKRFISIYRGPS-HTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIK 1058
             +  F ++  G +   +    L   + Y FR+ A +  G G   E    +T K   P   
Sbjct: 1422 PH-TFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPA-- 1478

Query: 1059 APR---VTQLEGNSCEILWETVPSMKG-DPVNY----ILQVLVGRESEYKQVYKGEEATF 1110
             PR   V Q E  +  +  + VP   G  P+ Y    + ++  G    Y      E    
Sbjct: 1479 PPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATAC 1538

Query: 1111 QISGLQTNTDYRFRVCA 1127
             +  L+  T Y+ R+ A
Sbjct: 1539 VVDRLRPFTSYKLRLKA 1555



 Score =  105 bits (261), Expect = 3e-22
 Identities = 193/822 (23%), Positives = 303/822 (36%), Gaps = 98/822 (11%)

Query: 311  SFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPV 370
            S  Y  +   SD       +++    E E  +++L    +Y +++ A      G  SE V
Sbjct: 1208 SVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVV 1267

Query: 371  SFTTHSCAPECPFPPKLAHRSKSS--LTLQWKAPIDN-------GSKITNYLLEWDEGKR 421
               T    P    P  ++  + SS  + L W +  +        G KI     + D   R
Sbjct: 1268 RGRTRESVPSAA-PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPR 1326

Query: 422  NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCY-TLGNIPQMPSA 480
            +   R     S     L K    + Y  ++ A   IG    S  ++   T  + P  P  
Sbjct: 1327 SHIVRGNHTQSALLAGLRKF---VLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVR 1383

Query: 481  PRLVRAGITWVTLQWSKPE---GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKN 537
                   +T V + W  PE   G      I Y L               T    T T  +
Sbjct: 1384 LVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT--D 1441

Query: 538  LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP-DRPGPPTRPLV-KGPVTSHGFSVKWDP 595
            L   + Y FRL+A   +G   P E  V TT   +RP PP   LV +  VT+    ++W P
Sbjct: 1442 LAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVP 1501

Query: 596  PKDNGGSEILKYLLEITD-GNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
              D G S I  + +++ +    E   +  + S  AT      L+P T YKLR    +  G
Sbjct: 1502 GSD-GASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560

Query: 655  HSQ-CSESLPVRTLSIAPGQCRPPRVLGRPKH--KEVHLEWDVPASES------GCEVSE 705
             S   SE+  V TL   PG+  PP  +    H    V ++W  P  ES      G  +  
Sbjct: 1561 DSDFSSETEAVTTLQDVPGE--PPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYY 1618

Query: 706  YSVEM-----TEPEDVASEVYHGPELE----------------CTVGNLLPGTVYRFRVR 744
              +E      TE + + + +    EL                 C + +L     Y   + 
Sbjct: 1619 RELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMT 1678

Query: 745  ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP--DGCVLVGWESP--DSSGADISEY 800
            A N  G  P S   E+      P       +  TP     + V W+ P  +S   +I  Y
Sbjct: 1679 AYNIIGESPASAPVEVFVGEAAPAMAPQN-VQVTPLTASQLEVTWDPPPPESQNGNIQGY 1737

Query: 801  RLEWGE-----DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ 855
            ++ + E     + E +++++   +    +++L    +Y   + AFN AG GP S+    +
Sbjct: 1738 KIYYWEADSQNETEKMKVLFL-PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGR 1796

Query: 856  TPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVG 915
            T  +AP   S L         A+ +  S  L ++W EP      +  Y +     +   G
Sbjct: 1797 THQAAPGAPSFL---------AFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQG 1847

Query: 916  NT---TMHV---------MKDLLPETTYRIRIQAINEIGAGPFSQF-IKAKTRPLPPLPP 962
             +   T+ V         ++DL    TY  R+QA   I  GP  Q  I A      P  P
Sbjct: 1848 VSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA-RTITYGPELQANITAGPAEGSPGSP 1906

Query: 963  RLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGP----SHTYKVQ 1018
            R          L L+W + +S        V   +  D     + +   P    S+T  + 
Sbjct: 1907 RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLD 1966

Query: 1019 RLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP 1060
            +L +   Y FR+ A +EAG G  S   T     +V   ++AP
Sbjct: 1967 KLRQGVTYEFRVVAVNEAGYGEPSNPST-----AVSAQVEAP 2003



 Score =  100 bits (248), Expect = 1e-20
 Identities = 207/974 (21%), Positives = 349/974 (35%), Gaps = 113/974 (11%)

Query: 276  LSGIEKPQVSNIQARAVVLS-----WAPPV-----GLSCGPHSGLSFPYSYEVALSDKGR 325
            L G+      N+Q  AV  +     W PP      G++ G +  L++P     A++    
Sbjct: 865  LQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQG-YKLLAWPADAPEAVTVVTI 923

Query: 326  DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP 385
               +  ++ G     ++ +L+  T Y   V        G  S P    T    P      
Sbjct: 924  APDFHGVHHG-----HITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHL 978

Query: 386  KLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH-CKLTKLCPA 444
                   +SL + W+ P++    IT Y + W+   RN         S  H  K+  L   
Sbjct: 979  SFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSL 1038

Query: 445  MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGIT--WVTLQWSKPEGC 501
              YT  +AA   +GT   +   +  + G  P +P AP  LV + I+    TLQ+ +P   
Sbjct: 1039 TTYTIDVAAVTAVGTGLVTSSTI--SSGVPPDLPGAPSNLVISNISPRSATLQF-RPGYD 1095

Query: 502  SPEEVITYTLEIQ------EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
                +  + +E Q      E+E   L+  +   +     + NL   T Y+FR+   N  G
Sbjct: 1096 GKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVG 1155

Query: 556  KS--CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKD---NGGSEILKYLLE 610
             S   PS  ++ T        PT   V+   +     ++W P  D   NG  E + Y ++
Sbjct: 1156 PSPYSPSSRVIQTLQAPPDVAPTSVTVR-TASETSLRLRWVPLPDSQYNGNPESVGYRIK 1214

Query: 611  ITDGNSEANQW-EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI 669
                + +++   +V       E+T   L+    Y+L+    +  G    SE +  RT   
Sbjct: 1215 YWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRES 1274

Query: 670  APGQCRPPRVLGRPKHKEVHLEW-DVPASESGCEVSEYSV----EMTEPEDVASEVYHGP 724
             P               ++ L W  VP  +    +  Y +    +  +PE  +  V    
Sbjct: 1275 VPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNH 1334

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSD--VSEITT--AAGPPGQCKAPCISCTPD 780
                 +  L    +Y  +V A    G G  S   + E T   A GPP +   P +  T  
Sbjct: 1335 TQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS- 1393

Query: 781  GCVLVGWESPDSSGADISEYRLEW---GEDEESLELIYHGTDTR-FEIRDLLPAAQYCCR 836
              V + W+ P+     I  Y++ +        +   +  G   R F   DL P + Y  R
Sbjct: 1394 --VRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFR 1451

Query: 837  LQAFNQAGAG-PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCN 895
            L A  + G G P    V+       P P   L V + E         +  L L W    +
Sbjct: 1452 LSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVT-------ARSLRLQWVPGSD 1504

Query: 896  NGSEILAYTIDLGD---------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPF 946
              S I  +T+ + +         +S      T  V+  L P T+Y++R++A N+IG   F
Sbjct: 1505 GASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDF 1564

Query: 947  SQFIKAKT--RPLPPLPP-RLECAAAGPQSLKLKW------------------------- 978
            S   +A T  + +P  PP  +        S+ ++W                         
Sbjct: 1565 SSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYE 1624

Query: 979  -GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAG 1037
             G           I    +L  ++          S   ++  L ++  Y   + A +  G
Sbjct: 1625 AGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIG 1684

Query: 1038 EGPFS---ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP--SMKGDPVNYIL--- 1089
            E P S   E +      ++ P  +  +VT L  +  E+ W+  P  S  G+   Y +   
Sbjct: 1685 ESPASAPVEVFVGEAAPAMAP--QNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYW 1742

Query: 1090 QVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRC-----LDTSQELSGAFSP 1144
            +     E+E  +V    E   ++  L ++T Y   + A          D  Q  +   +P
Sbjct: 1743 EADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP 1802

Query: 1145 SAAFVLQRSEVMLT 1158
             A   L  SE+  T
Sbjct: 1803 GAPSFLAFSEITST 1816



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 183/839 (21%), Positives = 304/839 (36%), Gaps = 101/839 (12%)

Query: 316  YEVALSDKGR-DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT 374
            Y+++    GR D +     +    E  ++ L   T Y + V A+  +  G+     S  +
Sbjct: 1005 YQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAV--TAVGTGLVTSSTIS 1062

Query: 375  HSCAPECPFPPK---LAHRSKSSLTLQWKAPIDNGSKITNYLLEW------DEGKRNSGF 425
                P+ P  P    +++ S  S TLQ++   D  + I+ +++E       DE +  + +
Sbjct: 1063 SGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLY 1122

Query: 426  RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQMPSAPRLV 484
             +      +  ++  L P   Y FR+   N +G S YS    V  TL   P +      V
Sbjct: 1123 EEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV 1182

Query: 485  RAG------ITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT--CTVK 536
            R        + WV L  S+  G +PE V  Y ++    +  +    +   + L    T++
Sbjct: 1183 RTASETSLRLRWVPLPDSQYNG-NPESV-GYRIKYWRSDLQSSAVAQVVSDRLEREFTIE 1240

Query: 537  NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD-- 594
             L+   +Y+ ++ A N  G    SEV+   T    P      +    V+S    + W   
Sbjct: 1241 ELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSV 1300

Query: 595  PPKDNGGSEI-LKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTG 653
            P +D  G  +  K L    D + E     +             L+   LY+L+    +  
Sbjct: 1301 PEQDQNGLILGYKILFRAKDLDPEPRS-HIVRGNHTQSALLAGLRKFVLYELQVLAFTRI 1359

Query: 654  GHSQCSESLPV-RTLSIAPGQCRPPRVLGRPKHK--EVHLEWDVPASESGCEVS---EYS 707
            G+   S  L + RT   APG   PP  L  P+ +   V + W  P   +G  +     Y 
Sbjct: 1360 GNGVPSTPLILERTKDDAPG---PPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416

Query: 708  VEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA--- 764
            +  + P    +        + T  +L P + Y FR+ A    G+G   + + ITT     
Sbjct: 1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRER 1476

Query: 765  -GPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY------RLEWGEDEESLELIYHG 817
              PP +   P    T     L  W  P S GA    Y       L  GE +     I H 
Sbjct: 1477 PAPPRELLVPQAEVTARSLRLQ-WV-PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHE 1534

Query: 818  TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP--- 874
              T   +  L P   Y  RL+A N  G   +S         S  + V+TL  +  EP   
Sbjct: 1535 A-TACVVDRLRPFTSYKLRLKATNDIGDSDFS---------SETEAVTTLQDVPGEPPGS 1584

Query: 875  LDAYPDSPSACLVLNWEEPCNN-------GSEI----LAYTIDLGDTSITVGN------- 916
            + A P + S+ L+  W+ P +        G  I    L Y    G  + T+ N       
Sbjct: 1585 VSATPHTTSSVLI-QWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAE 1643

Query: 917  ---------------TTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL- 960
                           +TM  +  L     Y + + A N IG  P S  ++       P  
Sbjct: 1644 LTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAM 1703

Query: 961  -PPRLECAAAGPQSLKLKWG----DSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY 1015
             P  ++        L++ W     +S +       I Y           + +   P    
Sbjct: 1704 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVV 1763

Query: 1016 KVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW 1074
            +++ LT  T Y   I A + AG+GP S+     T ++ P        +++   +  + W
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSW 1822



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 144/617 (23%), Positives = 224/617 (36%), Gaps = 75/617 (12%)

Query: 287  IQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLR 346
            ++  +V + W PP        +G+   Y     L+         +       +    DL 
Sbjct: 1389 VRLTSVRIVWQPPE-----EPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLA 1443

Query: 347  PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK-----LAHRSKSSLTLQWKA 401
            P + Y  R+ A      G   E    TT     E P PP+      A  +  SL LQW  
Sbjct: 1444 PESAYIFRLSAKTRQGWGEPLEATVITTEK--RERPAPPRELLVPQAEVTARSLRLQWVP 1501

Query: 402  PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKH----CKLTKLCPAMGYTFRLAARNDI 457
              D  S I  + ++  E  R  G  Q +  S  H    C + +L P   Y  RL A NDI
Sbjct: 1502 GSDGASPIRYFTMQVRELPR--GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDI 1559

Query: 458  GTSGYSQEVVCYT-LGNIP-QMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT----YTL 511
            G S +S E    T L ++P + P +        + V +QW  P   S   ++     Y  
Sbjct: 1560 GDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYR 1619

Query: 512  EIQED----------ENDNLFHPKYTGED-----------LTCTVKNLKRSTQYKFRLTA 550
            E++ +          +N    H + T +              C + +LK+  +Y+  +TA
Sbjct: 1620 ELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTA 1679

Query: 551  SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPP---KDNGGSEILKY 607
             N  G+S  S  +        P    + +   P+T+    V WDPP     NG  +  K 
Sbjct: 1680 YNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKI 1739

Query: 608  LLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTL 667
                 D  +E  + +V +          +L   T Y +     +  G    S+    RT 
Sbjct: 1740 YYWEADSQNETEKMKVLFLPEPV-VRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH 1798

Query: 668  SIAPGQCRPPRVLGRPK--HKEVHLEWDVPASESGCEVSEYSVEMTEP--------EDVA 717
              APG    P  L   +     +++ W  PA+ +G  +  Y V + EP        + V 
Sbjct: 1799 QAAPG---APSFLAFSEITSTTLNVSWGEPAAANGI-LQGYRV-VYEPLAPVQGVSKVVT 1853

Query: 718  SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT--AAGPPGQCKAPCI 775
             EV    +    V +L  G  Y FRV+A     YGP    + IT   A G PG  +   +
Sbjct: 1854 VEVRGNWQRWLKVRDLTKGVTYFFRVQA-RTITYGPELQ-ANITAGPAEGSPGSPRDVLV 1911

Query: 776  SCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESL------ELIYHGTDTRFEIRDLLP 829
            + +     L  W    S     + Y +E    +E L      ++    T     +  L  
Sbjct: 1912 TKSASELTL-QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQ 1970

Query: 830  AAQYCCRLQAFNQAGAG 846
               Y  R+ A N+AG G
Sbjct: 1971 GVTYEFRVVAVNEAGYG 1987



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 128/531 (24%), Positives = 193/531 (36%), Gaps = 72/531 (13%)

Query: 285  SNIQARAVVLSWAPPVGLSCGPHSGLSFPY-SYEVALSDKGRDGKYKIIYSGEELECNLK 343
            + + AR++ L W P      G        Y + +V    +G    Y    S E   C + 
Sbjct: 1488 AEVTARSLRLQWVP------GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVD 1541

Query: 344  DLRPATDYHVRVYAMYNSVKGS--CSEPVSFTTHSCAP-ECPFPPKLAHRSKSSLTLQWK 400
             LRP T Y +R+ A  N +  S   SE  + TT    P E P        + SS+ +QW+
Sbjct: 1542 RLRPFTSYKLRLKAT-NDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQ 1600

Query: 401  APIDN-------GSKITNYLLEWDEGK------------------RNSGFRQCFFGSQKH 435
             P D        G +I    LE++ G                     S F+     S   
Sbjct: 1601 PPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTST 1660

Query: 436  -CKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQM-PSAPRLVRAGITWVTL 493
             C+LT L     Y   + A N IG S  S  V  +     P M P   ++     + + +
Sbjct: 1661 MCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEV 1720

Query: 494  QWSKPEGCSPEEVIT-YTLEIQEDENDN-------LFHPKYTGEDLTCTVKNLKRSTQYK 545
             W  P   S    I  Y +   E ++ N       LF P     +    +KNL   T+Y 
Sbjct: 1721 TWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLP-----EPVVRLKNLTSHTKYL 1775

Query: 546  FRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKW-DPPKDNG---G 601
              ++A N  G    S+     T    PG P+  L    +TS   +V W +P   NG   G
Sbjct: 1776 VSISAFNAAGDGPKSDPQQGRTHQAAPGAPSF-LAFSEITSTTLNVSWGEPAAANGILQG 1834

Query: 602  SEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY--KLRACCISTGGHSQCS 659
              ++   L    G S+    EV  +          L  G  Y  +++A  I+ G   Q +
Sbjct: 1835 YRVVYEPLAPVQGVSKVVTVEVRGNWQRW-LKVRDLTKGVTYFFRVQARTITYGPELQAN 1893

Query: 660  ESLPVRTLSIAPGQCRPPR-VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVAS 718
                  T   A G    PR VL      E+ L+W           + Y +E    ++   
Sbjct: 1894 I-----TAGPAEGSPGSPRDVLVTKSASELTLQW-TEGHSGDTPTTGYVIEARPSDEGLW 1947

Query: 719  EVY------HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA 763
            +++             ++  L  G  Y FRV A+N+ GYG  S+ S   +A
Sbjct: 1948 DMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSA 1998


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  117 bits (292), Expect = 9e-26
 Identities = 203/882 (23%), Positives = 333/882 (37%), Gaps = 99/882 (11%)

Query: 269  VKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGK 328
            V+  +D+   +     S I   ++ +SW  P     G  +G+     Y ++  +  R   
Sbjct: 888  VRTHEDVPGPVGHLSFSEILDTSLKVSWQEP-----GEKNGILT--GYRISWEEYNRTNT 940

Query: 329  YKIIY-SGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPK- 386
                Y     LE  +  L   T Y + V AM +  +G  S   S  +    PE P PP  
Sbjct: 941  RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVS--ASTISSGVPPELPGPPTN 998

Query: 387  --LAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGS------QKHCKL 438
              +++    S+TLQ++   D  + I+ +L+E   G    G               +  ++
Sbjct: 999  LGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058

Query: 439  TKLCPAMGYTFRLAARNDIGTSGYSQEV-VCYTLGNIPQM-PSAPRLVRAGITWVTLQWS 496
              L P   Y+FR+   N +GTS  SQ      TL   P M P+   L  A  T + L+W 
Sbjct: 1059 PDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWM 1118

Query: 497  K-PE---GCSPEEVITYTLEIQEDENDN--LFHPKYTGEDLTCTVKNLKRSTQYKFRLTA 550
              PE     +PE V  Y ++    +     L H      +   T+++L+  T+Y+ ++ A
Sbjct: 1119 PLPEMEYNGNPESV-GYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQA 1177

Query: 551  SNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD--PPKDNGGSEI-LKY 607
             N  G    S+ +V  T    P      +     TS    V+W   P  D  G  +  K 
Sbjct: 1178 FNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237

Query: 608  LLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST-GGHSQCSESLPVRT 666
            + +  D +++   W V    S+     T L    LY+++    +  G  S     +  RT
Sbjct: 1238 MYKEKDSDTQPRFWLVE-GNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT 1296

Query: 667  LSIAPGQCRPPRVLGRPKHK--EVHLEWDVPASESGCEVS---EYSVEMTEPEDVASEVY 721
            L   PG   PP  +  P+ +   V L W  PA+ +G  ++    + +  T       EV 
Sbjct: 1297 LDDVPG---PPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVL 1353

Query: 722  HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPD- 780
                 + T   L P +VY FR+ A    G+G  ++   +TT      Q  +  +    D 
Sbjct: 1354 APSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDV 1413

Query: 781  --GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTD-----TRFEIRDLLPAAQY 833
                VL+ WE P S G     Y      +  S     H        + F +  L P   Y
Sbjct: 1414 RARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSY 1472

Query: 834  CCRLQAFNQAGAGPYSE-LVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEE 892
              R++A N  G   +SE      T  +APD   T+       L   P + ++ L+  W+ 
Sbjct: 1473 KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-------LSVTPHTTTSVLI-RWQP 1524

Query: 893  PCNN-------GSEI----LAYTIDLGDTSITVGN--------TTMHVMKDLL-PETT-- 930
            P  +       G  I    L Y    G T   + N        T+M+ M++L  P  T  
Sbjct: 1525 PAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584

Query: 931  ----------YRIRIQAINEIGAGPFSQFIKAKTRPLPPL--PPRLECAAAGPQSLKLKW 978
                      Y IR+   N +G GP S   +       P   P  +    A    L + W
Sbjct: 1585 ELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTW 1644

Query: 979  -----GDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAA 1033
                    N      +   +  Q  +  +R  +++    ++ K++ LT +T Y   + A 
Sbjct: 1645 EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA-ENSVKLKNLTGYTAYMVSVAAF 1703

Query: 1034 SEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWE 1075
            + AG+GP S      T ++ P    + + ++L   S  + WE
Sbjct: 1704 NAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745



 Score =  115 bits (287), Expect = 3e-25
 Identities = 193/833 (23%), Positives = 312/833 (37%), Gaps = 94/833 (11%)

Query: 294  LSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKY--KIIYSGEELECNLKDLRPATDY 351
            L W P   +    ++G      Y++  S     GK    ++    E +  ++DL   T+Y
Sbjct: 1115 LRWMPLPEME---YNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEY 1171

Query: 352  HVRVYAMYNSVKGSCSEPVSFTTHSCAPEC-PFPPKLAHRSKSSLTLQWKA--PIDNGSK 408
             V+V A      G  S+ V   T    P   P        + SS+ ++W      D    
Sbjct: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231

Query: 409  ITNYLLEWDEGKRNSGFRQCFF----GSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQ 464
            +  Y + + E  ++S  +  F+     S +  +LT L   + Y  ++ A   IG    S 
Sbjct: 1232 VLGYKVMYKE--KDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH 1289

Query: 465  EVVCY-TLGNIPQMPSAPRLVRAGITWVTLQW---SKPEGCSPEEVITYTLEIQEDENDN 520
              +   TL ++P  P          T V L W   + P G      IT+ L         
Sbjct: 1290 PPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTAT 1349

Query: 521  LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP-DRPGPPTRPL 579
            +     +    T T   LK  + Y FR+TA   +G    +E LV TT   DRP PP+RP+
Sbjct: 1350 VEVLAPSARQYTAT--GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM 1407

Query: 580  VKGP-VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV---AYSGSATEYTFT 635
            V+   V +    + W+P  D G S +  Y ++  +  S   +W +   + S +A+ +   
Sbjct: 1408 VQQEDVRARSVLLSWEPGSD-GLSPVRYYTIQTRELPS--GRWALHSASVSHNASSFIVD 1464

Query: 636  HLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIAPGQCRPPRVLGRPKHK--EVHLEW 692
             LKP T YK R    +  G S+ SE S  + TL  AP +   P +L    H    V + W
Sbjct: 1465 RLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA--PTILSVTPHTTTSVLIRW 1522

Query: 693  DVPASES--------GCEVSEYSVE---------MTEPEDVASEV--------YHGPEL- 726
              PA +              E   E         +  P    +E+           P L 
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582

Query: 727  ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVL-V 785
            +  + NL     Y  R+   N  G GP S   E+      P       +        L V
Sbjct: 1583 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 1642

Query: 786  GWESP--DSSGADISEYRLEWGEDE-----ESLELIYHGTDTRFEIRDLLPAAQYCCRLQ 838
             WE P  DS   DI  Y++ + E +     E ++ ++   ++  ++++L     Y   + 
Sbjct: 1643 TWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENS-VKLKNLTGYTAYMVSVA 1701

Query: 839  AFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGS 898
            AFN AG GP S     QT  +AP   S++          + +  +  + ++WE P     
Sbjct: 1702 AFNAAGDGPRSTPTQGQTQQAAPSAPSSV---------KFSELTTTSVNVSWEAPQFPNG 1752

Query: 899  EILAYT--------IDLGDTSITV---GNTTMHV-MKDLLPETTYRIRIQAINEIGAGPF 946
             +  Y         +D     +TV   GN+ + + +KDL    TYR RI+A         
Sbjct: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812

Query: 947  SQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFIS 1006
               +        P PP +        ++ + W   +         V   +  D     I 
Sbjct: 1813 EANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDIL 1872

Query: 1007 IYRGP----SHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVP 1054
            I   P    S+T+ +  L     Y FR+ A ++ G G P S + +    K+ P
Sbjct: 1873 IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925



 Score =  112 bits (280), Expect = 2e-24
 Identities = 188/830 (22%), Positives = 297/830 (35%), Gaps = 118/830 (14%)

Query: 378  APECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK 437
            APE P    L+   + ++ L W  P D  S +  Y+LE  E              +    
Sbjct: 592  APEHPVAT-LSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSV 650

Query: 438  LTK-LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGIT--WVTLQ 494
              K L PA  Y FRL A ND+G   +S++    +L   P       ++ +G T   + +Q
Sbjct: 651  TVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQ 710

Query: 495  WSKP-----EGCSPEEVITYTL----------EIQEDENDNLFHPKYTGEDLTCTVKNLK 539
            W  P      G     +I Y L           I + + +NL             +++L 
Sbjct: 711  WQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLL------------LEDLI 758

Query: 540  RSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKD- 598
              T Y+  + A N+ G    S  +   T    P  P   +      S      W+ P   
Sbjct: 759  IWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQ 818

Query: 599  --NGGSEILKYLL-------EITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACC 649
              NG ++  K +        E+T   +  N  +  + G  +      LK  T Y     C
Sbjct: 819  FINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSG-----LKKFTEYFTSVLC 873

Query: 650  ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV-----HLEWDVPASESGCEVS 704
             +T G    S    VRT    PG       +G     E+      + W  P  ++G  ++
Sbjct: 874  FTTPGDGPRSTPQLVRTHEDVPGP------VGHLSFSEILDTSLKVSWQEPGEKNGI-LT 926

Query: 705  EYSVEMTEPEDVASEVYH---GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEIT 761
             Y +   E     + V H      LE  V  L   T Y   V A+   G G    VS  T
Sbjct: 927  GYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG---QVSAST 983

Query: 762  TAAGPPGQCKAPC----ISCTPDGCVLVGWESPDSSGADISEYRLEW-----GEDEESLE 812
             ++G P +   P     IS      V + +         IS + +E      GE EE L 
Sbjct: 984  ISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLL 1043

Query: 813  L--IYHGTDTR-FEIRDLLPAAQYCCRLQAFNQAGAGPYSE-----LVLCQTPASAPDPV 864
            +  + +  D R  E+ DL P   Y  R++  N  G  P S+       L   P  AP  V
Sbjct: 1044 IHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANV 1103

Query: 865  STLCVLEEEPLDAYPDSPSACLVLNW----EEPCNNGSEILAYTIDLGDTSITVGNTTMH 920
            S     E              L L W    E   N   E + Y I     S   G T  H
Sbjct: 1104 SLRTASETS------------LWLRWMPLPEMEYNGNPESVGYKIKYS-RSDGHGKTLSH 1150

Query: 921  VMKDLLPE----------TTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--PPRLECAA 968
            V++D +            T YR+++QA N IG+GP+SQ +  +TR   P   P  +   A
Sbjct: 1151 VVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALA 1210

Query: 969  AGPQSLKLKWGD----SNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFT 1024
                S+ ++W +      +       ++Y  +  D   RF  +    S + ++  L ++ 
Sbjct: 1211 TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYV 1270

Query: 1025 CYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGD 1083
             Y  ++ A +  G+G P        T   VP         ++   S  ++W+   +  G 
Sbjct: 1271 LYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330

Query: 1084 PVNYILQVLVG---RESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRR 1130
             + Y +   +      +   +V       +  +GL+  + Y FR+ A  R
Sbjct: 1331 ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 1380



 Score =  105 bits (263), Expect = 2e-22
 Identities = 203/887 (22%), Positives = 339/887 (38%), Gaps = 114/887 (12%)

Query: 290  RAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPAT 349
            +++++ W PP        +G+   Y     L+      ++K I   +     L+DL   T
Sbjct: 705  QSIMIQWQPPPE---SHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWT 761

Query: 350  DYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQ--WKAP----- 402
            +Y + V A  ++  G  S  V+  T    P  P P  +   + +S T++  W AP     
Sbjct: 762  NYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVP-PGNVHAEATNSTTIRFTWNAPSPQFI 820

Query: 403  --IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
              I+ G K+  +  E +E       R  F  S            +G+   L    +  TS
Sbjct: 821  NGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIH----------VGFVSGLKKFTEYFTS 870

Query: 461  GYSQEVVCYTL-GNIPQMPSAPRLVRAGI----------------TWVTLQWSKPEGCSP 503
                 V+C+T  G+ P+  S P+LVR                   T + + W +P G   
Sbjct: 871  -----VLCFTTPGDGPR--STPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP-GEKN 922

Query: 504  EEVITYTLEIQEDENDNLFHPKYTGE-DLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 562
              +  Y +  +E    N     Y     L   V  L   T Y   + A  ++G+   S  
Sbjct: 923  GILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAS 982

Query: 563  LVCT-TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN-SEANQ 620
             + +   P+ PGPPT   +   +     ++++ P  D G + I ++L+E   G   E  +
Sbjct: 983  TISSGVPPELPGPPTNLGISN-IGPRSVTLQFRPGYD-GKTSISRWLVEAQVGVVGEGEE 1040

Query: 621  W----EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE-SLPVRTLSIAPGQCR 675
            W    +++    A       L P T Y  R   ++  G S  S+ S  ++TL   P    
Sbjct: 1041 WLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAP 1100

Query: 676  PPRVLGRPKHKEVHLEW-DVPASE--SGCEVSEYSVEMTEPEDVASEVYH----GPELEC 728
                L       + L W  +P  E     E   Y ++ +  +     + H      E + 
Sbjct: 1101 ANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDY 1160

Query: 729  TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPP--GQCKAPCISCTPDGCVLVG 786
            T+ +L   T YR +V+A N  G GP+S      T    P  G      ++ T    +LV 
Sbjct: 1161 TIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSS-MLVR 1219

Query: 787  W-ESPDSS-GADISEYRLEWGEDEESLE----LIYHGTDTRFEIRDLLPAAQYCCRLQAF 840
            W E P++     +  Y++ + E +   +    L+   +    ++  L     Y  ++ AF
Sbjct: 1220 WSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAF 1279

Query: 841  NQAGAG-PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSE 899
             + G G P    +L +T    P P   +          +P+  +  + L W+ P      
Sbjct: 1280 TRIGDGSPSHPPILERTLDDVPGPPMGIL---------FPEVRTTSVRLIWQPPAAPNGI 1330

Query: 900  ILAYTIDLGDTSITVGNTTMHVMKD---------LLPETTYRIRIQAINEIGAGPFSQFI 950
            ILAY I     + T    T+ V+           L PE+ Y  RI A    G G  ++ +
Sbjct: 1331 ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390

Query: 951  KAKT----RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDR-NKRFI 1005
               T    RP PP  P ++      +S+ L W   +          YT+Q  +  + R+ 
Sbjct: 1391 VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR--YYTIQTRELPSGRWA 1448

Query: 1006 SIYRGPSH---TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP-- 1060
                  SH   ++ V RL  FT Y FR++A ++ G+  FSE     TT    P  +AP  
Sbjct: 1449 LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD-EAPTI 1507

Query: 1061 -RVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQ-VYKG 1105
              VT     S  I W+     K      I  +L+G    Y++ +Y+G
Sbjct: 1508 LSVTPHTTTSVLIRWQPPAEDK------INGILLGFRIRYRELLYEG 1548


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  108 bits (270), Expect = 3e-23
 Identities = 158/644 (24%), Positives = 253/644 (39%), Gaps = 67/644 (10%)

Query: 339  ECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPE-CPFPPKLAHRSKSSLTL 397
            + N+ DL PA+ Y +R+Y+     +   S+ ++ +T   AP+  P    L   +  S+ +
Sbjct: 1006 QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQV 1065

Query: 398  QWKAP---IDNGSKITNYLLEWDEGKRNSGFRQCFF-----GSQKHCKLTKLCPAMGYTF 449
             WKAP   + NG  I  Y + + E    S  +         G  +   L  L     Y  
Sbjct: 1066 TWKAPKKELQNG-VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124

Query: 450  RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA-GIT--WVTLQWSKPEGCSPEEV 506
             + A N  GT   S E+   TL ++P  P  P  VRA  IT     + WS+P    P   
Sbjct: 1125 VVQAFNRAGTGPSSSEINATTLEDVPSQP--PENVRALSITSDVAVISWSEP----PRST 1178

Query: 507  ITYTLEIQEDENDNLFHPKYTGE--DLTCT-----VKNLKRSTQYKFRLTASNTEGKSCP 559
            +   L+       +L+     GE  ++T T     ++ +++ T Y  ++ A    G    
Sbjct: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238

Query: 560  SEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPP-KDNGGSEILKYLLEITD-GNSE 617
            S VL   T  D PGPP   +   P ++    V W PP K NG   I KY +  +  G+ +
Sbjct: 1239 SSVLYIQTKEDVPGPPA-GIKAVPSSASSVVVSWLPPTKPNG--VIRKYTIFCSSPGSGQ 1295

Query: 618  ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP- 676
                E   S     Y   HL  G  Y L    +++ G    SE + +     AP +    
Sbjct: 1296 PAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISF 1355

Query: 677  PRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT-EPEDVASEV-YHGPELECTVGNLL 734
               +  P  K+V L    P +  G      +V+ T + ED A  V   G  L  T G LL
Sbjct: 1356 GGTVTTPWMKDVRL----PCNSVGDPAP--AVKWTKDSEDSAIPVSMDGHRLIHTNGTLL 1409

Query: 735  PGTVYR-----FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES 789
               V       +   A N GG+    D   +      P       +S T    + + W  
Sbjct: 1410 LRAVKAEDSGYYTCTATNTGGF----DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIP 1465

Query: 790  PDSSGADISEYRLEWGED--EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGP 847
             D+ G+ I  + L++  D  EE  ++    ++  F++  L     Y  +L A N  G+G 
Sbjct: 1466 GDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525

Query: 848  YSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL-NWEEPCNNGSEILAYTID 906
             SE++  +T    P         +++ L  + +S  A L L  W    N G  I A  ++
Sbjct: 1526 ISEIIEAKTHGREPS------FSKDQHLFTHINSTHARLNLQGWN---NGGCPITAIVLE 1576

Query: 907  LGD------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG 944
                       +   ++    + +L   T Y +R++A N  G G
Sbjct: 1577 YRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1620



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 175/747 (23%), Positives = 283/747 (37%), Gaps = 91/747 (12%)

Query: 380  ECPFPPKLAHRSKS--SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQC---FFGSQK 434
            E P PP+L  R     S+ L+W    D  S IT + +E+     +  F+Q       +  
Sbjct: 946  EPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTIN 1005

Query: 435  HCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQ 494
               +  L PA  Y+ R+ + N IG S  S+E+   T    P  P     ++  +T  ++Q
Sbjct: 1006 QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQP-VTSQSIQ 1064

Query: 495  --WSKPEGCSPEEVIT-YTLEIQEDENDN-----LFHPKYTGEDLTCTVKNLKRSTQYKF 546
              W  P+      VI  Y +  +E+   +     +   K TG+    T+ NLK+  QY  
Sbjct: 1065 VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124

Query: 547  RLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILK 606
             + A N  G    S  +  TT  D P  P   +    +TS    + W  P  +  + +LK
Sbjct: 1125 VVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK 1184

Query: 607  YLLEITDGNSEANQWEVAYSGSAT--EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV 664
                I        +W    + + T        ++  T Y ++    +  G    S  L +
Sbjct: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYI 1244

Query: 665  RTLSIAPGQCRPPRVLGRPKH-KEVHLEWDVPASESGCEVSEYSVEMTEP---EDVASEV 720
            +T    PG   P  +   P     V + W  P   +G  + +Y++  + P   +   SE 
Sbjct: 1245 QTKEDVPGP--PAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEY 1301

Query: 721  YHGPE-LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTP 779
               PE L   + +L  G  Y   V A+   G G  S+   I  A       KAP    + 
Sbjct: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG------KAPAKIISF 1355

Query: 780  DGCVLVGW----ESPDSSGADISEYRLEWGEDEESL---------ELIYHGTDTRFEIRD 826
             G V   W      P +S  D +   ++W +D E            LI+           
Sbjct: 1356 GGTVTTPWMKDVRLPCNSVGDPAP-AVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVK 1414

Query: 827  LLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL 886
               +  Y C   A N  G       +L Q P   PD          +P      + ++ +
Sbjct: 1415 AEDSGYYTC--TATNTGGFDTIIVNLLVQVP---PD----------QPRLTVSKTSASSI 1459

Query: 887  VLNWEEPCNNGSEI----LAYTIDLGD--TSITVGNTTMHVMKDLLP-ETTYRIRIQAIN 939
             L W    N GS I    L Y++D  +    + + ++      D L   T Y++++ A N
Sbjct: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519

Query: 940  EIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI-------- 991
             +G+G  S+ I+AKT    P       + +  Q L   +   NS THA  ++        
Sbjct: 1520 SVGSGRISEIIEAKTHGREP-------SFSKDQHL---FTHINS-THARLNLQGWNNGGC 1568

Query: 992  -VYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTF 1047
             +  + LE R K    +  +    S    +  L E T Y  R++A + AG G  +ET  F
Sbjct: 1569 PITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG--NETAQF 1626

Query: 1048 STTKSVPPTIKAPRVTQLEGNSCEILW 1074
            +T      TI   +  Q EG+  + L+
Sbjct: 1627 ATLDYDGSTIPPIKSAQGEGDDVKKLF 1653



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 49/220 (22%), Positives = 84/220 (38%), Gaps = 17/220 (7%)

Query: 924  DLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAA--AGPQSLKLKWGDS 981
            DL P + Y IR+ + N+IG    S+ +   T    P  P ++        QS+++ W   
Sbjct: 1011 DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAP 1070

Query: 982  NSKTHAAEDIVYTLQLEDRNKRFISIYR-------GPSHTYKVQRLTEFTCYSFRIQAAS 1034
              +        Y +   + +      Y        G S  Y +  L +F  Y   +QA +
Sbjct: 1071 KKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFN 1130

Query: 1035 EAGEGPFSETYTFSTTKSVP-PTIKAPRVTQLEGNSCEILWETVPS------MKGDPVNY 1087
             AG GP S     +T + VP    +  R   +  +   I W   P       +KG  V +
Sbjct: 1131 RAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1190

Query: 1088 ILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
                + G   E + +    E   ++ G++  T+Y  +V A
Sbjct: 1191 WSLYVDGEWGEMQNITTTRERV-ELRGMEKFTNYSVQVLA 1229



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 36/170 (21%), Positives = 69/170 (40%), Gaps = 16/170 (9%)

Query: 958  PPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR----FISIYRGPSH 1013
            PP PP LE      +S+ L+W    ++      I+    +E +NK     F    R  S 
Sbjct: 947  PPDPPELEIREVKARSMNLRW----TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISP 1002

Query: 1014 TYKVQRLTEF---TCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSC 1070
            T     + +    + YS R+ + ++ G    S+  T ST ++ P     P    L+  + 
Sbjct: 1003 TINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPD--GPPMDVTLQPVTS 1060

Query: 1071 EILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTD 1120
            + +  T  + K +  N +++   G +  Y++   G    + I  ++   D
Sbjct: 1061 QSIQVTWKAPKKELQNGVIR---GYQIGYRENSPGSNGQYSIVEMKATGD 1107


>gi|140560917 myomesin 1 isoform b [Homo sapiens]
          Length = 1589

 Score =  106 bits (265), Expect = 1e-22
 Identities = 138/541 (25%), Positives = 208/541 (38%), Gaps = 83/541 (15%)

Query: 378  APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHC 436
            AP  P   K    +K  + + WK P +D GS I  Y ++  E   +S + QC     K  
Sbjct: 509  APAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDS-WSQCNDTPVKFA 567

Query: 437  K--LTKLCPAMGYTFRLAARNDIG---TSGYSQEVVCY---------------------- 469
            +  +T L     Y FR+ A N +G    S  S+ V                         
Sbjct: 568  RFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIV 627

Query: 470  -----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE--DENDNLF 522
                 + G +P  P+   +  A  ++V L W KP G    E I Y +E  E   EN    
Sbjct: 628  TEEEPSEGIVPGPPTDLSVTEATRSYVVLSW-KPPGQRGHEGIMYFVEKCEAGTENWQRV 686

Query: 523  HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP--LV 580
            + +   +     + +L     Y FR+  SN+ G   PSE    T   D+   P  P  ++
Sbjct: 687  NTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKII 746

Query: 581  KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLK 638
                T     V W+  KD    E++ Y +E +   S   +WE   +     + +T   L 
Sbjct: 747  PSRNTDTSVVVSWEESKD--AKELVGYYIEASVAGS--GKWEPCNNNPVKGSRFTCHGLV 802

Query: 639  PGTLYKLRACCISTGG---HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVP 695
             G  Y  R   ++  G   +SQ SE++ V+  +IAP                + L W  P
Sbjct: 803  TGQSYIFRVRAVNAAGLSEYSQDSEAIEVKA-AIAPPSPPCDITCLESFRDSMVLGWKQP 861

Query: 696  ASESGCEVSEYSVEMTEPEDVASEVYHGPELECT------VGNLLPGTVYRFRVRALNDG 749
                G E++ Y V   E  D     +    ++        + NL    VY+F+V A+N  
Sbjct: 862  DKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMA 921

Query: 750  GYGPYSDVSE-------ITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSG-------- 794
            G G  S VSE            GPP   K  C     D  VL  W+ P  SG        
Sbjct: 922  GLGAPSAVSECFKCEEWTIAVPGPPHSLK--CSEVRKDSLVL-QWKPPVHSGRTPVTGYF 978

Query: 795  ADISEYRL---EW-GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSE 850
             D+ E +    +W G +E +++ +Y       ++R L     Y  R++A NQAG G  S+
Sbjct: 979  VDLKEAKAKEDQWRGLNEAAIKNVY------LKVRGLKEGVSYVFRVRAINQAGVGKPSD 1032

Query: 851  L 851
            L
Sbjct: 1033 L 1033



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 122/484 (25%), Positives = 185/484 (38%), Gaps = 55/484 (11%)

Query: 382  PFPP---KLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCK- 437
            P PP    +   ++S + L WK P   G +   Y +E  E    +  R       K  + 
Sbjct: 638  PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRF 697

Query: 438  -LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLV---RAGITWVTL 493
             L  L     Y FR+   N  G    S+      +G+   +P AP  +   R   T V +
Sbjct: 698  ALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVV 757

Query: 494  QWSKPEGCSPEEVITYTLEIQ-------EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKF 546
             W   E    +E++ Y +E         E  N+N       G   TC    L     Y F
Sbjct: 758  SWE--ESKDAKELVGYYIEASVAGSGKWEPCNNN----PVKGSRFTC--HGLVTGQSYIF 809

Query: 547  RLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVK--WDPPKDNGGSEI 604
            R+ A N  G S  S+            PP+ P     + S   S+   W  P   GG+EI
Sbjct: 810  RVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEI 869

Query: 605  LKYLL---EITDGNSEANQWEVAYSGSATE--YTFTHLKPGTLYKLRACCISTGG---HS 656
              Y +   E+ DG     +W  A   + +E  Y  ++LK   +Y+ +   ++  G    S
Sbjct: 870  TGYYVNYREVIDG--VPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPS 927

Query: 657  QCSESLPVRTLSIA-PGQCRPPRVL--GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP 713
              SE       +IA PG   PP  L     +   + L+W  P       V+ Y V++ E 
Sbjct: 928  AVSECFKCEEWTIAVPG---PPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEA 984

Query: 714  EDVASEVYHG------PELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPP 767
            +    + + G        +   V  L  G  Y FRVRA+N  G G  SD++    A   P
Sbjct: 985  K-AKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVAETRP 1043

Query: 768  GQCKAPCISCTPDGCVLVGWE----SPDSSGADISEYRLEWGEDEESLELIYHGTDTRFE 823
            G  K   ++   DG + + +E    +P S  +   +Y     ED   LE+   G  T+  
Sbjct: 1044 G-TKEVVVNVDDDGVISLNFECDKMTPKSEFSWSKDYVST--EDSPRLEVESKGNKTKMT 1100

Query: 824  IRDL 827
             +DL
Sbjct: 1101 FKDL 1104



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 145/600 (24%), Positives = 225/600 (37%), Gaps = 109/600 (18%)

Query: 526  YTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTRPL-VKGP 583
            ++GE  T T  +L +  +  + +     E  +   + V V     +  G P  PL VK  
Sbjct: 460  WSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCL 519

Query: 584  VTSHGFSV-KWDPPKDNGGSEILKYLLEI----TDGNSEANQWEVAYSGSATEYTFTHLK 638
              +  + +  W  P  +GGS IL Y ++     TD  S+ N   V ++     +  T L 
Sbjct: 520  EANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFA----RFPVTGLI 575

Query: 639  PGTLYKLRACCISTGGHSQCSE-SLPVRTLS----------------------------- 668
             G  Y  R   ++  G    S  S PV  L                              
Sbjct: 576  EGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEG 635

Query: 669  IAPGQCRPPRVLG--RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPEL 726
            I PG   PP  L         V L W  P  + G E   Y VE  E     +E +     
Sbjct: 636  IVPG---PPTDLSVTEATRSYVVLSWK-PPGQRGHEGIMYFVEKCE---AGTENWQRVNT 688

Query: 727  ECTVGN-------LLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAP---CIS 776
            E  V +       L  G  Y FRVR  N  G G  S+ +E+T         KAP     S
Sbjct: 689  ELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPS 748

Query: 777  CTPDGCVLVGWESPDSSGADISEYRLEW-----GEDEESLELIYHGTDTRFEIRDLLPAA 831
               D  V+V WE       ++  Y +E      G+ E        G+  RF    L+   
Sbjct: 749  RNTDTSVVVSWEE-SKDAKELVGYYIEASVAGSGKWEPCNNNPVKGS--RFTCHGLVTGQ 805

Query: 832  QYCCRLQAFNQAGAGPYS---ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVL 888
             Y  R++A N AG   YS   E +  +   + P P   +  LE     ++ DS    +VL
Sbjct: 806  SYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLE-----SFRDS----MVL 856

Query: 889  NWEEPCN-NGSEILAYTIDLGDT-----------SITVGNTTMHVMKDLLPETTYRIRIQ 936
             W++P    G+EI  Y ++  +            ++   +   + + +L     Y+ ++ 
Sbjct: 857  GWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVA 916

Query: 937  AINEIGAGP---FSQFIKAK--TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
            A+N  G G     S+  K +  T  +P  P  L+C+     SL L+W       H+    
Sbjct: 917  AMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQW---KPPVHSGRTP 973

Query: 992  V--YTLQLEDRNKRFISIYRGPSHT------YKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
            V  Y + L++   +    +RG +         KV+ L E   Y FR++A ++AG G  S+
Sbjct: 974  VTGYFVDLKEAKAKEDQ-WRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSD 1032



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/584 (22%), Positives = 219/584 (37%), Gaps = 90/584 (15%)

Query: 619  NQW-EVAYSGSATEYTFTHLKPGT--LYKLRACCISTGGH-SQCSESLPVRTLS--IAPG 672
            ++W +  +SG     TF+HL      LY +R   +  G +  Q S  + VR     I   
Sbjct: 453  SKWVQTLWSGERATLTFSHLNKEDEGLYTIR---VRMGEYYEQYSAYVFVRDADAEIEGA 509

Query: 673  QCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVYHGPE--LEC 728
               P  V     +K+ + + W  PA + G  +  Y ++  E   D  S+    P      
Sbjct: 510  PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569

Query: 729  TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---------------------- 766
             V  L+ G  Y FRVRA+N  G G  S VSE   A  P                      
Sbjct: 570  PVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTE 629

Query: 767  --------PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE----WGEDEESLELI 814
                    PG      ++      V++ W+ P   G +   Y +E      E+ + +   
Sbjct: 630  EEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTE 689

Query: 815  YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP 874
                  RF + DL     YC R++  N AG G  SE       A+    V     + + P
Sbjct: 690  LPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSE-------ATEVTVVGDKLDIPKAP 742

Query: 875  LDAYPD-SPSACLVLNWEEPCNNGSEILAYTID-----------LGDTSITVGNTTMHVM 922
                P  +    +V++WEE   +  E++ Y I+             +  +     T H  
Sbjct: 743  GKIIPSRNTDTSVVVSWEE-SKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCH-- 799

Query: 923  KDLLPETTYRIRIQAINEIGAGPFSQ---FIKAKTRPLPPLPP-RLECAAAGPQSLKLKW 978
              L+   +Y  R++A+N  G   +SQ    I+ K    PP PP  + C  +   S+ L W
Sbjct: 800  -GLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGW 858

Query: 979  GDSNSKTHAAEDIVYTLQLED------RNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
               + K   AE   Y +   +         R  ++       YK+  L E   Y F++ A
Sbjct: 859  KQPD-KIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAA 917

Query: 1033 ASEAGEG-PFSETYTFST---TKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN-- 1086
             + AG G P + +  F     T +VP    + + +++  +S  + W+        PV   
Sbjct: 918  MNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGY 977

Query: 1087 -YILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCA 1127
               L+    +E +++ + +   +    ++ GL+    Y FRV A
Sbjct: 978  FVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRA 1021



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 14/178 (7%)

Query: 291  AVVLSWAPPVGLSCGPHSGLSFPYSYEV-ALSDKGRDGKYKIIYSGEELECNLKDLRPAT 349
            ++VL W  P  +     +G    Y   +  +  K R+   K +    E    + +L+   
Sbjct: 853  SMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAV---SEEAYKISNLKENM 909

Query: 350  DYHVRVYAMYNSVKGSCSEPVS-FTTHSCAPECPFPP---KLAHRSKSSLTLQWKAPIDN 405
             Y  +V AM  +  G+ S     F         P PP   K +   K SL LQWK P+ +
Sbjct: 910  VYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHS 969

Query: 406  G-SKITNYLLEWDEGKRNS----GFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIG 458
            G + +T Y ++  E K       G  +       + K+  L   + Y FR+ A N  G
Sbjct: 970  GRTPVTGYFVDLKEAKAKEDQWRGLNEAAI-KNVYLKVRGLKEGVSYVFRVRAINQAG 1026


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo
            sapiens]
          Length = 1250

 Score =  105 bits (261), Expect = 3e-22
 Identities = 134/546 (24%), Positives = 221/546 (40%), Gaps = 62/546 (11%)

Query: 546  FRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
            ++  A N+ G +C +  L        P  PTR +   P++S    V W+ P+ +   +I+
Sbjct: 403  YQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHS-EQII 460

Query: 606  KYLLEITDGNSEAN-QWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV 664
             + L         N +++ A +   TE     L+P T Y+      S  G S+ S    V
Sbjct: 461  GFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALV 520

Query: 665  RTLSIAPGQCRPPRVLGRPKHKEVHLEW-DVPASESGCEVSEYSVE--MTEPEDVASEVY 721
             TL   P    P   L  P   ++ + W  +P S S  +V +Y +E  + + + + S   
Sbjct: 521  HTLDDVPSAA-PQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEV 579

Query: 722  HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAG--------PPGQCKAP 773
             G E +  + +L P  VYR R+ A    G+G  S      T +          P + K  
Sbjct: 580  RGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQ 639

Query: 774  CISCTPDGCVLVGWESPDSSGADISEYRLEW----GEDEESLELIYHGTDTR-------- 821
                +    ++V W+ P      IS Y+L W     E+E + + +  G   +        
Sbjct: 640  AKMES----LVVSWQPPPHP-TQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVR 694

Query: 822  -------FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTP-ASAPD-PVSTLCVLEE 872
                   +E+  L+P   Y  +L AFN+   G Y+ +   +T  A APD P+     L  
Sbjct: 695  LKKKVKQYELTQLVPGRLYEVKLVAFNKHEDG-YAAVWKGKTEKAPAPDMPIQRGPPLPP 753

Query: 873  EPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI-----DLGDTSITVGNTTMH---VMKD 924
              + A  +S S  + L W++P     +I+ YT+      L + S+    T+     ++  
Sbjct: 754  AHVHAESNS-STSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDILIGG 812

Query: 925  LLPETTYRIRIQAINEIGAGPFSQFIKAKTRP-LPPLPPR-LECAAAGPQSLKLKWGDSN 982
            L P T Y   +Q+      GPF   ++  T P  P  PP  L  +   P +++L W    
Sbjct: 813  LKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPP- 871

Query: 983  SKTHAAEDIVYTLQLEDRNKR------FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEA 1036
              T    +IV  L L   N         +   +G   + +V  L   T Y F++ A +E 
Sbjct: 872  --TEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEV 929

Query: 1037 GEGPFS 1042
            G GPFS
Sbjct: 930  GPGPFS 935



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 128/555 (23%), Positives = 209/555 (37%), Gaps = 71/555 (12%)

Query: 446 GYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEE 505
           GY ++  A N  G +  +  +       +P  P+         + V + W +PE  S E+
Sbjct: 401 GY-YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHS-EQ 458

Query: 506 VITYTLEIQEDEN-DNLFHPKYTGEDLT-CTVKNLKRSTQYKFRLTASNTEGKSCPSEVL 563
           +I ++L  Q+    DN+ +      D T   V++L+ +T Y+F + A +  G S  S   
Sbjct: 459 IIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518

Query: 564 VCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDP-PKDNGGSEILKYLLEITDGNSEANQWE 622
           +  T  D P    +  +  P  S    V W P P      +++KY +E   G  E   + 
Sbjct: 519 LVHTLDDVPSAAPQLSLSSPNPSD-IRVAWLPLPPSLSNGQVVKYKIEYGLGK-EDQIFS 576

Query: 623 VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI---APGQCRPPRV 679
               G+ T+     L+P  +Y++R    +  G    S+ +  RT S+   +     P  +
Sbjct: 577 TEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAEL 636

Query: 680 LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGN------- 732
             + K + + + W  P   +  ++S Y +   E    A E  +G  L    G+       
Sbjct: 637 KVQAKMESLVVSWQPPPHPT--QISGYKLYWREVG--AEEEANGDRLPGGRGDQAWDVGP 692

Query: 733 --------------LLPGTVYRFRVRALN--DGGYG----------PYSDVSEITTAAGP 766
                         L+PG +Y  ++ A N  + GY           P  D+        P
Sbjct: 693 VRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLP 752

Query: 767 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE---WGEDEESLELIYHGTDTRFE 823
           P    A   S T    + + W+ PD +   I  Y +    WG    SL   Y  +     
Sbjct: 753 PAHVHAESNSSTS---IWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809

Query: 824 IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPS 883
           I  L P  +Y   +Q+      GP+  +V   T    PD  ST        L   P +PS
Sbjct: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERST---LPDRPST----PPSDLRLSPLTPS 862

Query: 884 ACLVLNWEEPCNNGSEILAYTIDLGDTSI----------TVGNTTMHVMKDLLPETTYRI 933
             + L+W  P     EI+ Y I                 T GN     +  L  +T Y  
Sbjct: 863 T-VRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFF 921

Query: 934 RIQAINEIGAGPFSQ 948
           ++ A  E+G GPFS+
Sbjct: 922 KMGARTEVGPGPFSR 936



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 107/514 (20%), Positives = 188/514 (36%), Gaps = 46/514 (8%)

Query: 379 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDE--GKRNSGFRQCFFGSQKHC 436
           P  P        S S++ + W+ P  +  +I  + L + +  G  N  ++          
Sbjct: 429 PSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTEL 488

Query: 437 KLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMP-----SAPRLVRAGITWV 491
           ++  L P   Y F + A + +G S  S   + +TL ++P        S+P      + W+
Sbjct: 489 QVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548

Query: 492 TLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTAS 551
            L    P   S  +V+ Y +E    + D +F  +  G +    + +L+ +  Y+ R++A 
Sbjct: 549 PL----PPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAG 604

Query: 552 NTEGKSCPSEVLVCTTSP--DRPGPPTRPL-VKGPVTSHGFSVKWDPPKDNGGSEILKYL 608
              G   PS+ +   T    ++   P  P  +K         V W PP         K  
Sbjct: 605 TAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLY 664

Query: 609 LEITDGNSEAN-----------QWEVA---YSGSATEYTFTHLKPGTLYKLRACCIST-- 652
                   EAN            W+V          +Y  T L PG LY+++    +   
Sbjct: 665 WREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHE 724

Query: 653 GGHSQC----SESLPVRTLSIAPGQCRPPRVLGRPKHKE--VHLEWDVPASESGCEVSEY 706
            G++      +E  P   + I  G   PP  +    +    + L W  P   +  ++  Y
Sbjct: 725 DGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTT-VKIVNY 783

Query: 707 SVEMTE--PEDVASEVYHGPELE-CTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA 763
           +V  +     + +   Y+    E   +G L P T Y F V++      GP+  V E +T 
Sbjct: 784 TVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTL 843

Query: 764 AGPPGQCKAPC-ISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLE-----LIYHG 817
              P    +   +S      V + W  P     +I EY + +  +    E     L   G
Sbjct: 844 PDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQG 903

Query: 818 TDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL 851
                E+  L    +Y  ++ A  + G GP+S L
Sbjct: 904 NIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRL 937



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 105/504 (20%), Positives = 193/504 (38%), Gaps = 62/504 (12%)

Query: 676  PPRVLGRP-KHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVY----HGPELECTV 730
            P RV   P     V + W+ P   S  ++  +S+   +   + +  Y    +    E  V
Sbjct: 432  PTRVTATPLSSSAVLVAWERPEMHSE-QIIGFSLHYQKARGMDNVEYQFAVNNDTTELQV 490

Query: 731  GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWES- 789
             +L P T Y F V A +  G    S  + + T    P       +S      + V W   
Sbjct: 491  RDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPL 550

Query: 790  -PDSSGADISEYRLEWG--EDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAG 846
             P  S   + +Y++E+G  ++++       G +T+  +  L P   Y  R+ A   AG G
Sbjct: 551  PPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFG 610

Query: 847  PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI- 905
              S+ +  +TP+     +     +   P +    +    LV++W+ P  + ++I  Y + 
Sbjct: 611  APSQWMHHRTPS-----MHNQSHVPFAPAELKVQAKMESLVVSWQPP-PHPTQISGYKLY 664

Query: 906  -----------------DLGDTSITVGNTTM------HVMKDLLPETTYRIRIQAINEIG 942
                               GD +  VG   +      + +  L+P   Y +++ A N+  
Sbjct: 665  WREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHE 724

Query: 943  AGPFSQFIKAKTRPLP----------PLPP-RLECAAAGPQSLKLKWGDSNSKTHAAEDI 991
             G ++   K KT   P          PLPP  +   +    S+ L+W   +  T   + +
Sbjct: 725  DG-YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTT--VKIV 781

Query: 992  VYTLQLED---RNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFS 1048
             YT++      RN   ++ Y        +  L  FT Y F +Q+     +GPF      S
Sbjct: 782  NYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841

Query: 1049 TTKSVPPTIKAP-RVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQ----VY 1103
            T    P T  +  R++ L  ++  + W       G+ V Y++           Q      
Sbjct: 842  TLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTT 901

Query: 1104 KGEEATFQISGLQTNTDYRFRVCA 1127
            +G   + ++ GL+++T Y F++ A
Sbjct: 902  QGNIFSAEVHGLESDTRYFFKMGA 925



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 102/393 (25%), Positives = 164/393 (41%), Gaps = 56/393 (14%)

Query: 269 VKRVQDILSGIEKPQVSNIQARAVVLSWAP-PVGLSCGPHSGLSFPYSYEVALSDKGRDG 327
           V  + D+ S   +  +S+     + ++W P P  LS    +G    Y  E  L  +  D 
Sbjct: 520 VHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLS----NGQVVKYKIEYGLGKE--DQ 573

Query: 328 KYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPEC--PFPP 385
            +     G E +  L  L+P   Y VR+ A   +  G+ S+ +   T S   +   PF P
Sbjct: 574 IFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAP 633

Query: 386 -KLAHRSK-SSLTLQWKAPIDNGSKITNYLLEWDE--------GKRNSGFRQCFFGSQ-- 433
            +L  ++K  SL + W+ P  + ++I+ Y L W E        G R  G R    G Q  
Sbjct: 634 AELKVQAKMESLVVSWQPP-PHPTQISGYKLYWREVGAEEEANGDRLPGGR----GDQAW 688

Query: 434 -----------KHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYT-LGNIPQMP--S 479
                      K  +LT+L P   Y  +L A N     GY+      T     P MP   
Sbjct: 689 DVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNK-HEDGYAAVWKGKTEKAPAPDMPIQR 747

Query: 480 APRLVRAGI-------TWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKY---TGE 529
            P L  A +       T + L+W KP+  +  +++ YT+        N     Y   +GE
Sbjct: 748 GPPLPPAHVHAESNSSTSIWLRWKKPD-FTTVKIVNYTVRFSPWGLRNASLVTYYTSSGE 806

Query: 530 DLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGF 589
           D+   +  LK  T+Y+F + +   +       V+  +T PDRP  P   L   P+T    
Sbjct: 807 DIL--IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTV 864

Query: 590 SVKWDPPKDNGGSEILKYLLEITDGNSE-ANQW 621
            + W PP +  G EI++YL+  +  +++  +QW
Sbjct: 865 RLHWCPPTEPNG-EIVEYLILYSSNHTQPEHQW 896



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 116/523 (22%), Positives = 186/523 (35%), Gaps = 67/523 (12%)

Query: 287 IQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDG-KYKIIYSGEELECNLKDL 345
           + + AV+++W  P   S      + F   Y+ A   +G D  +Y+   + +  E  ++DL
Sbjct: 440 LSSSAVLVAWERPEMHS---EQIIGFSLHYQKA---RGMDNVEYQFAVNNDTTELQVRDL 493

Query: 346 RPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQW--KAPI 403
            P TDY   V A         S P    T    P       L+  + S + + W    P 
Sbjct: 494 EPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPS 553

Query: 404 DNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYS 463
            +  ++  Y +E+  GK +  F     G++    L  L P   Y  R++A    G    S
Sbjct: 554 LSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS 613

Query: 464 QEVVCYT--LGNIPQMPSAPR--LVRAGITWVTLQWSKPEGCSPEEVITYTL---EIQED 516
           Q +   T  + N   +P AP    V+A +  + + W  P    P ++  Y L   E+  +
Sbjct: 614 QWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPP--HPTQISGYKLYWREVGAE 671

Query: 517 ENDNLFH-PKYTGEDL--TCTVKNLKRSTQYKF-----------RLTASNTEGKSCPSEV 562
           E  N    P   G+       V+  K+  QY+            +L A N   K      
Sbjct: 672 EEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFN---KHEDGYA 728

Query: 563 LVCTTSPDRPGPPTRPLVKGPV-----------TSHGFSVKWDPPKDNGGSEILKYLLEI 611
            V     ++   P  P+ +GP            +S    ++W  P D    +I+ Y +  
Sbjct: 729 AVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKP-DFTTVKIVNYTVRF 787

Query: 612 TDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP 671
           +            Y+ S  +     LKP T Y+                 +   TL   P
Sbjct: 788 SPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRP 847

Query: 672 GQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSE----YSVEMTEPEDVASEVYHGPELE 727
                   L       V L W  P   +G E+ E    YS   T+PE       H   L 
Sbjct: 848 STPPSDLRLSPLTPSTVRLHWCPPTEPNG-EIVEYLILYSSNHTQPE-------HQWTLL 899

Query: 728 CTVGNLLPGTV--------YRFRVRALNDGGYGPYSDVSEITT 762
            T GN+    V        Y F++ A  + G GP+S + ++ T
Sbjct: 900 TTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
            sapiens]
          Length = 2299

 Score =  100 bits (248), Expect = 1e-20
 Identities = 173/748 (23%), Positives = 280/748 (37%), Gaps = 101/748 (13%)

Query: 267  LEVKRVQDILSG-IEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGR 325
            +EV   QDI  G +      +I + A+ +SW PP        +GL F Y   + L    R
Sbjct: 1044 IEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPA-----QPNGLVF-YYVSLILQQTPR 1097

Query: 326  DGKYKIIYSGEELECNLKDLRPATDYHVRVY-AMYNSVKGSCSEPVSFTTHSCAPEC-PF 383
              +  ++    E      +L   TDY +++  +       + +  +   T    PE  P 
Sbjct: 1098 HVRPPLVTY--ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPI 1155

Query: 384  PPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
                 + S +S+ L W  P+     I +Y L       N  F      S  +  L +L P
Sbjct: 1156 INTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSF----ITSDNYIILEELSP 1211

Query: 444  AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAP-RLVRAGITWVTLQWSKPEGCS 502
               Y+F  AAR   G  G S  +  YT  ++P  P     L+     +V L+WS P    
Sbjct: 1212 FTLYSFFAAARTRKGL-GPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS-PSPLP 1269

Query: 503  PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 562
               V  Y+ +I E E D +++   +G      +  L+  + Y  R++A    G       
Sbjct: 1270 GGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSN 1329

Query: 563  LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
            +V  T+ +      + +     +     VKWDPPK   G  I +Y++ +     E N  +
Sbjct: 1330 VVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGI-ITQYMVTV-----ERNSTK 1383

Query: 623  VAYSGSATEYTFTHLKPGTLY--KLRACCIS-TGGHSQCSESLPVRTLSIAPGQC----- 674
            V  S     YTF  L   T Y  K+RA   +  G  S C  S    T+   P        
Sbjct: 1384 V--SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDV 1441

Query: 675  ----------RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGP 724
                      RP  +LG  ++ ++  +         C+  E S E  E + +   +Y   
Sbjct: 1442 QSTSATLTWIRPDTILGYFQNYKITTQ----LRAQKCKEWE-SEECVEYQKI-QYLYEAH 1495

Query: 725  ELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPP-GQCKAPCISCTPDGCV 783
              E TV  L     YRF+V A  + GYG  S+     T  GPP G  +   +  T    +
Sbjct: 1496 LTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSI 1555

Query: 784  LVGWESP-----------DSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQ 832
             + W  P           D    D  E+ + + +  E  + I        EI+DL    +
Sbjct: 1556 SISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTI--------EIKDLEIFTR 1607

Query: 833  YCCRLQAFNQAGAGPY------SELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL 886
            Y   + AF    +  Y      +E+++    ++  DP + +           PD  +   
Sbjct: 1608 YSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNM------TFQKIPDEVTKFQ 1661

Query: 887  VLNWEEPCNNGS----EILAYTIDLGDTSITVGNTT---------MHVMKDLLPETTYRI 933
            +        NG+    + L Y  D   T++ + N +         + +++ L    TY I
Sbjct: 1662 LTFLPPSQPNGNIQVYQALVYRED-DPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNI 1720

Query: 934  RIQAINEIGAGP-----FSQFIKAKTRP 956
             + A+N  GAGP      +  IKA  RP
Sbjct: 1721 SVYAVNSAGAGPKVPMRITMDIKAPARP 1748



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 159/665 (23%), Positives = 258/665 (38%), Gaps = 77/665 (11%)

Query: 476  QMPSAPRLVR---AGITWVTLQWSKPEGCSPEEVIT-YTLEIQEDENDNLFHPKYTGEDL 531
            Q+PS+ +++       + + L W  PE   P   IT YT+   E + +  F  + T  D 
Sbjct: 567  QVPSSIKIINYKNISSSSILLYWDPPE--YPNGKITHYTIYAMELDTNRAF--QITTIDN 622

Query: 532  TCTVKNLKRSTQYKFRLTASNTEGKSCPSEV--LVCTTSPDRPGPPTRPLVKGPVTSHGF 589
            +  +  LK+ T+YK R+ AS   G+S  SE   +   TS D P    + +    VT+   
Sbjct: 623  SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEI 682

Query: 590  SVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACC 649
             +KW PP+   G  I+ Y  E+   N +    +   + S T+    +L+P TLY +    
Sbjct: 683  RLKWSPPEKPNGI-IIAY--EVLYKNIDTLYMK---NTSTTDIILRNLRPHTLYNISVRS 736

Query: 650  ISTGGH-SQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSV 708
             +  GH +Q S  L VRT    P               E+ L +  P+S +G  + +Y++
Sbjct: 737  YTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGI-IQKYTI 795

Query: 709  EMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYG----PYSDVSEITTAA 764
             +           +   L   +  L   T Y   V A    G G    P S ++E     
Sbjct: 796  YLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 855

Query: 765  GPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEI 824
             PP       +S      V + W+ P      I  Y + +  +  SL+ I + T+T  E+
Sbjct: 856  SPPQDFSVKQLSGV---TVKLSWQPPLEPNGIILYYTV-YVWNRSSLKTI-NVTETSLEL 910

Query: 825  RDLLPAAQYCCRLQAFNQAGAG-PYSELVLCQTPASAPDPVSTLCVLEEEPLDA-YPDSP 882
             DL    +Y   + A  + G G   S ++  QTP  AP          + P D  Y +  
Sbjct: 911  SDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAP---------SDPPKDVYYANLS 961

Query: 883  SACLVLNWEEPCNNGSEILAYTIDLGDTSIT-VGNTTMH-------------VMKDLLPE 928
            S+ ++L W  P      I  Y++   +TS T + N T+H             ++  L   
Sbjct: 962  SSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIF 1021

Query: 929  TTYRIRIQAINEIGAG-PFSQFIKAKTRPLPP--LPPRLECAAAGPQSLKLKWGDSNSKT 985
            + Y   + A   +G G   S  I+  T    P      L   +    ++ + W       
Sbjct: 1022 SYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN 1081

Query: 986  HAAEDIVYTLQLEDRNKRFISIYRGPSHTYK----VQRLTEFTCYSFRIQAASEAGEGPF 1041
                   Y   +  +  R +   R P  TY+       L ++T Y  +I  ++E G   F
Sbjct: 1082 GLV--FYYVSLILQQTPRHV---RPPLVTYERSIYFDNLEKYTDYILKITPSTEKG---F 1133

Query: 1042 SETYT----FSTTKSVPPTIKAPRVT---QLEGNSCEILWETVPSMKGDPVNYILQVLVG 1094
            S+TYT      T + VP T  +P +     L   S  + W+      G  ++Y L  L G
Sbjct: 1134 SDTYTAQLYIKTEEDVPET--SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL-TLQG 1190

Query: 1095 RESEY 1099
                Y
Sbjct: 1191 PNENY 1195



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 199/934 (21%), Positives = 351/934 (37%), Gaps = 103/934 (11%)

Query: 246  KTERRARSSPKSNDSDL-QEYELEVKRVQDIL-SGIEKPQVSNIQARAVVLSWAPPVGLS 303
            K + R  +S    +S L +E ++ V+  +D   S  +  +V ++ A  + L W+PP    
Sbjct: 634  KYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPE--- 690

Query: 304  CGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYH--VRVYAMY-- 359
                +G+    +YEV    K  D  Y  + +    +  L++LRP T Y+  VR Y  +  
Sbjct: 691  --KPNGIII--AYEVLY--KNIDTLY--MKNTSTTDIILRNLRPHTLYNISVRSYTRFGH 742

Query: 360  -NSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSS--LTLQWKAPIDNGSKITNYLLEW 416
             N V    S   S T    APE      + +++ SS  + L +  P      I  Y +  
Sbjct: 743  GNQVSSLLSVRTSETVPDSAPE-----NITYKNISSGEIELSFLPPSSPNGIIQKYTIYL 797

Query: 417  DEGKRNSGFRQCFFGSQKHCKLTKLCPAMG-YTFRLAARNDIGTSGYSQEVVCYTLGNIP 475
               KR++G  +    +    +  K+      Y   ++A    G    S  +   T  + P
Sbjct: 798  ---KRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAP 854

Query: 476  QMPSAPRLVR--AGITWVTLQWSKPEGCSPEEVITY-TLEIQEDENDNLFHPKYTGEDLT 532
              P     V+  +G+T V L W  P    P  +I Y T+ +    +    +   T  +L+
Sbjct: 855  DSPPQDFSVKQLSGVT-VKLSWQPP--LEPNGIILYYTVYVWNRSSLKTINVTETSLELS 911

Query: 533  CTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPD-RPGPPTRPLVKGPVTSHGFSV 591
                +L  + +Y   +TAS   G       ++   +P+  P  P + +    ++S    +
Sbjct: 912  ----DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967

Query: 592  KWDPP-KDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTF-THLKPGTLYKLRACC 649
             W PP K NG  +        T G    N      +      T  T +   T++      
Sbjct: 968  FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027

Query: 650  I----STGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEV-----HLEWDVPASESG 700
            +    S G  ++ S+ + V T      Q  P   +G   ++ +     ++ W  PA  +G
Sbjct: 1028 LTASTSVGNGNKSSDIIEVYT-----DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNG 1082

Query: 701  CEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGP-YSDVSE 759
                  S+ + +            E      NL   T Y  ++    + G+   Y+    
Sbjct: 1083 LVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLY 1142

Query: 760  ITTAAGPPGQCKAPCISCTPD---GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYH 816
            I T    P    +P I+   +     VL+ W+ P      I  Y L      E+   I  
Sbjct: 1143 IKTEEDVPET--SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFIT- 1199

Query: 817  GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP-DPVSTLCVLEEEPL 875
             +D    + +L P   Y     A  + G GP S ++   T  S P  P   L ++     
Sbjct: 1200 -SDNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLI----- 1252

Query: 876  DAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV-------GNTTMHVMKDLLPE 928
                +  S  + L W      G  +  Y+  + +            G  T   +  L P 
Sbjct: 1253 ----NCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPV 1308

Query: 929  TTYRIRIQAINEIGAG-PFSQFIKAKTRP-LPPLPPRLECAAAGPQSLKLKWGDSNSKTH 986
            +TY IR+ A  ++G G  FS  +K  T+  +P +   ++C A   QS+ +KW        
Sbjct: 1309 STYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANG 1368

Query: 987  AAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYT 1046
                 + T++   RN   +S      H Y   +L   T Y F+++A++ AGEG  S  + 
Sbjct: 1369 IITQYMVTVE---RNSTKVS---PQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422

Query: 1047 FSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRES--------- 1097
             +  ++VP        + ++  S  + W    ++ G   NY +   +  +          
Sbjct: 1423 STLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEEC 1482

Query: 1098 -EYKQV---YKGEEATFQISGLQTNTDYRFRVCA 1127
             EY+++   Y+       + GL+    YRF+V A
Sbjct: 1483 VEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAA 1516



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 152/741 (20%), Positives = 276/741 (37%), Gaps = 115/741 (15%)

Query: 336  EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSL 395
            + LE  L +L P T Y ++V A  ++  G  S+P  F T   AP       +   + S++
Sbjct: 112  DSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAV 171

Query: 396  TLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARN 455
             L W  P     KIT++ +                 S KH                 AR+
Sbjct: 172  KLIWYLPRQPNGKITSFKI-----------------SVKH-----------------ARS 197

Query: 456  DIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEG--CSPEEVITYTLEI 513
             I     S  V     G +P+             W T   S   G    P      +  +
Sbjct: 198  GIVVKDVSIRVEDILTGKLPECNENSE----SFLWSTASPSPTLGRVTPPSRTTHSSSTL 253

Query: 514  QEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPG 573
             ++E  +++      E ++  V +L+  T Y F ++A+ TE     S ++   T    P 
Sbjct: 254  TQNEISSVWK-----EPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIV--RTPESVPE 306

Query: 574  PPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
             P +  V G +T   FS+ WDPP    G     Y +E+   +       +  S    ++ 
Sbjct: 307  GPPQNCVTGNITGKSFSILWDPPTIVTGK--FSYRVELYGPSGRI----LDNSTKDLKFA 360

Query: 634  FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWD 693
            FT+L P T+Y +     ++ G    S ++ V T    PG     + L   +  +V + W 
Sbjct: 361  FTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPGAVFDLQ-LAEVESTQVRITWK 418

Query: 694  VPASESGCEVSEYSVEMTEPED---------VASEVYHGPELECTVGNLLPGTVYRFRVR 744
             P   +G  +++Y V++  PE            +  Y    +   + N++   V      
Sbjct: 419  KPRQPNGI-INQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMV------ 471

Query: 745  ALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEW 804
             L +G     SD+  + T             +  PD        + D +   ++  R ++
Sbjct: 472  GLYEGSAEMSSDLHSLATF----------IYNSHPDKNFPARNRAEDQTSPVVTT-RNQY 520

Query: 805  GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPV 864
              D  + +L Y        IR L+P  ++   + AF   G GP + L + +T    P  +
Sbjct: 521  ITDIAAEQLSY-------VIRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSI 572

Query: 865  STLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI---DLGDTSITVGNTTM-- 919
              +          Y +  S+ ++L W+ P     +I  YTI   +L DT+     TT+  
Sbjct: 573  KII---------NYKNISSSSILLYWDPPEYPNGKITHYTIYAMEL-DTNRAFQITTIDN 622

Query: 920  -HVMKDLLPETTYRIRIQAINEIGAGPFSQ----FIKAKTRPLPPLPPRLECAAAGPQSL 974
              ++  L   T Y++R+ A   +G    S+    F++         P  +E        +
Sbjct: 623  SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEI 682

Query: 975  KLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
            +LKW    S       I+   ++  +N   + +    +    ++ L   T Y+  +++ +
Sbjct: 683  RLKW----SPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYT 738

Query: 1035 EAGEG-PFSETYTFSTTKSVP 1054
              G G   S   +  T+++VP
Sbjct: 739  RFGHGNQVSSLLSVRTSETVP 759



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 179/892 (20%), Positives = 316/892 (35%), Gaps = 74/892 (8%)

Query: 267  LEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRD 326
            L V+  Q + S I+     NI + +++L W PP      P+  ++    Y + L D  R 
Sbjct: 560  LSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEY----PNGKITHYTIYAMEL-DTNRA 614

Query: 327  GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEP--VSFTTHSCAPEC-PF 383
             +   I    +    +  L+  T Y +RV A  +  + S SE   +   T    PE  P 
Sbjct: 615  FQITTI----DNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQ 670

Query: 384  PPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
              ++   +   + L+W  P     K    ++ ++   +N         S     L  L P
Sbjct: 671  DVEVIDVTADEIRLKWSPP----EKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRP 726

Query: 444  AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
               Y   + +    G       ++           +   +    I+   ++ S     SP
Sbjct: 727  HTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSP 786

Query: 504  EEVIT-YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 562
              +I  YT+ ++    +           LT  +K LK+ TQY   ++AS  +G+   S  
Sbjct: 787  NGIIQKYTIYLKRSNGNE--ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAP 844

Query: 563  LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNS--EANQ 620
            +   T  D P  P +      ++     + W PP +  G  IL Y + + + +S    N 
Sbjct: 845  ISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGI-ILYYTVYVWNRSSLKTINV 903

Query: 621  WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVL 680
             E +   S  +Y   +    T           G     S  +  +T   AP         
Sbjct: 904  TETSLELSDLDYNVEYSAYVT------ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957

Query: 681  GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTV-- 738
                   + L W  P+  +G  +  YSV          + +   E+     N+   T+  
Sbjct: 958  ANLSSSSIILFWTPPSKPNGI-IQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIID 1016

Query: 739  -------YRFRVRALNDGGYG-PYSDVSEITTAAGPP----GQCKAPCISCTPDGCVLVG 786
                   Y F + A    G G   SD+ E+ T    P    G      IS T    + V 
Sbjct: 1017 KLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISST---AINVS 1073

Query: 787  WESPDSSGADISEY---RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
            W  P      +  Y    L+         L+ +     F+  +L     Y  ++    + 
Sbjct: 1074 WVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFD--NLEKYTDYILKITPSTEK 1131

Query: 844  G-AGPYSELVLCQTPASAPDPVSTLCVLEEEP-LDAYPDSPSACLVLNWEEPCNNGSEIL 901
            G +  Y+  +  +T    P         E  P ++ + +  S  ++L+W+ P      I+
Sbjct: 1132 GFSDTYTAQLYIKTEEDVP---------ETSPIINTFKNLSSTSVLLSWDPPVKPNGAII 1182

Query: 902  AYTIDL---GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFS--QFIKAKTRP 956
            +Y + L    +    + +    ++++L P T Y     A    G GP S   F   ++ P
Sbjct: 1183 SYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP 1242

Query: 957  LPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYK 1016
            L P P  L         + LKW  S       +   + +   + +  +     G     K
Sbjct: 1243 LAP-PQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAK 1301

Query: 1017 VQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWE 1075
            +  L   + YS R+ A ++ G G  FS    F+T +SVP  ++  +       S  + W+
Sbjct: 1302 LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD 1361

Query: 1076 TVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
              P  K + +  I Q +V  E    +V   ++  +    L  NT Y F+V A
Sbjct: 1362 --PPKKANGI--ITQYMVTVERNSTKV-SPQDHMYTFIKLLANTSYVFKVRA 1408



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 150/711 (21%), Positives = 260/711 (36%), Gaps = 70/711 (9%)

Query: 438  LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITW--VTLQW 495
            +T L P   Y F ++A      +GY    +  T  ++P+ P     V   IT    ++ W
Sbjct: 270  VTHLRPYTTYLFEVSAATT--EAGYIDSTIVRTPESVPEGPPQ-NCVTGNITGKSFSILW 326

Query: 496  SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
              P   + +   +Y +E+       L +   + +DL     NL   T Y   + A  + G
Sbjct: 327  DPPTIVTGK--FSYRVELYGPSGRILDN---STKDLKFAFTNLTPFTMYDVYIAAETSAG 381

Query: 556  KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
                S + V T  PD PG     L    V S    + W  P+   G  I +Y +++    
Sbjct: 382  TGPKSNISVFTP-PDVPGA-VFDLQLAEVESTQVRITWKKPRQPNGI-INQYRVKVLVPE 438

Query: 616  SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCR 675
            +         +G+  EY    + P  +  +        G ++ S  L      I      
Sbjct: 439  TGIILENTLLTGN-NEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNS--- 494

Query: 676  PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE---DVASEVYHGPELECTVGN 732
                         H + + PA  +  E     V  T  +   D+A+E     +L   +  
Sbjct: 495  -------------HPDKNFPA-RNRAEDQTSPVVTTRNQYITDIAAE-----QLSYVIRR 535

Query: 733  LLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS 792
            L+P T +   V A    G GP + +S + T    P   K           +L+ W+ P+ 
Sbjct: 536  LVPFTEHMISVSAFTIMGEGPPTVLS-VRTRQQVPSSIKIINYKNISSSSILLYWDPPEY 594

Query: 793  SGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL- 851
                I+ Y +   E + +        D  F I  L    +Y  R+ A    G    SE  
Sbjct: 595  PNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEEN 654

Query: 852  -VLCQT----PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTI- 905
             +  +T    P S+P  V  + V  +E            + L W  P      I+AY + 
Sbjct: 655  DIFVRTSEDEPESSPQDVEVIDVTADE------------IRLKWSPPEKPNGIIIAYEVL 702

Query: 906  --DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG-PFSQFIKAKTRPLPP--L 960
              ++    +   +TT  ++++L P T Y I +++    G G   S  +  +T    P   
Sbjct: 703  YKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSA 762

Query: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
            P  +         ++L +   +S     +   YT+ L+  N          S T  ++ L
Sbjct: 763  PENITYKNISSGEIELSFLPPSSPNGIIQK--YTIYLKRSNGNEERTINTTSLTQNIKVL 820

Query: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP-RVTQLEGNSCEILWETVPS 1079
             ++T Y   + A++  GEG  S   +  T +  P +      V QL G + ++ W+  P 
Sbjct: 821  KKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ--PP 878

Query: 1080 MKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRR 1130
            ++ + +     V V   S  K +    E + ++S L  N +Y   V A  R
Sbjct: 879  LEPNGIILYYTVYVWNRSSLKTI-NVTETSLELSDLDYNVEYSAYVTASTR 928



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 146/668 (21%), Positives = 243/668 (36%), Gaps = 122/668 (18%)

Query: 535  VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWD 594
            V N+   T+Y   +++ +T   S  + ++  TT+  +PGPP   L    V S G  + W+
Sbjct: 21   VSNVVPGTRYDITISSISTTYTSPVTRIV--TTNVTKPGPPVF-LAGERVGSAGILLSWN 77

Query: 595  -PPKDNGGSEILKYLLEITDGNSEANQW------EVAYSGSATEYTFTHLKPGTLYKLRA 647
             PP  NG   I+ Y+++      E   W      +V     + E   T+L PGT Y+++ 
Sbjct: 78   TPPNPNG--RIISYIVKY----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131

Query: 648  CCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--------------RPKHKEVHLEWD 693
               ++ G    S+    +T   APG+     V                +P  K    +  
Sbjct: 132  AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKIS 191

Query: 694  VPASESGCEVSEYSVEM------------------------------------------- 710
            V  + SG  V + S+ +                                           
Sbjct: 192  VKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSS 251

Query: 711  TEPEDVASEVYHGPELECTVGNLLPGTVYRFRV-RALNDGGYGPYSDV-SEITTAAGPPG 768
            T  ++  S V+  P +   V +L P T Y F V  A  + GY   + V +  +   GPP 
Sbjct: 252  TLTQNEISSVWKEP-ISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQ 310

Query: 769  QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE-WGEDEESLELIYHGTDTRFEIRDL 827
             C    I+        + W+ P       S YR+E +G     L+      D +F   +L
Sbjct: 311  NCVTGNIT---GKSFSILWDPPTIVTGKFS-YRVELYGPSGRILD--NSTKDLKFAFTNL 364

Query: 828  LPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV 887
             P   Y   + A   AG GP S + +  TP   P  V  L + E E         S  + 
Sbjct: 365  TPFTMYDVYIAAETSAGTGPKSNISVF-TPPDVPGAVFDLQLAEVE---------STQVR 414

Query: 888  LNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIR---IQAINEIGAG 944
            + W++P      I  Y +                 K L+PET   +    +   NE    
Sbjct: 415  ITWKKPRQPNGIINQYRV-----------------KVLVPETGIILENTLLTGNNEYIND 457

Query: 945  PFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSN-----SKTHAAEDIVYTLQLED 999
            P +  I     P+  L       ++   SL     +S+        + AED   T  +  
Sbjct: 458  PMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAED--QTSPVVT 515

Query: 1000 RNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKA 1059
               ++I+       +Y ++RL  FT +   + A +  GEGP     +  T + VP +IK 
Sbjct: 516  TRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSSIKI 574

Query: 1060 PRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNT 1119
                 +  +S  + W+      G   +Y +  +    +   Q+   +  +F I+GL+  T
Sbjct: 575  INYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDN-SFLITGLKKYT 633

Query: 1120 DYRFRVCA 1127
             Y+ RV A
Sbjct: 634  KYKMRVAA 641



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 112/477 (23%), Positives = 170/477 (35%), Gaps = 66/477 (13%)

Query: 628  SATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG--RPKH 685
            S T+   +++ PGT Y +    IST   S  +    V T    PG   PP  L   R   
Sbjct: 15   SETQVDVSNVVPGTRYDITISSISTTYTSPVTRI--VTTNVTKPG---PPVFLAGERVGS 69

Query: 686  KEVHLEWDVPASESGCEVSEYSVEMTEP----EDVASEVYHGPE-LECTVGNLLPGTVYR 740
              + L W+ P + +G  +S Y V+  E     + V ++V   P+ LE  + NL PGT Y 
Sbjct: 70   AGILLSWNTPPNPNGRIIS-YIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYE 128

Query: 741  FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEY 800
             +V A N  G G +SD     TA   PG+     +       V + W  P      I+ +
Sbjct: 129  IKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSF 188

Query: 801  RLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCC--RLQAFNQAGAGPYSELVLCQTPA 858
            ++        + +     D    + D+L      C    ++F  + A P   L     P+
Sbjct: 189  KISVKHARSGIVV----KDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244

Query: 859  SAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTT 918
                  STL   E   +              W+EP +                       
Sbjct: 245  RTTHSSSTLTQNEISSV--------------WKEPIS----------------------- 267

Query: 919  MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAG--PQSLKL 976
              V+  L P TTY   + A     AG     I      +P  PP+  C       +S  +
Sbjct: 268  -FVVTHLRPYTTYLFEVSAAT-TEAGYIDSTIVRTPESVPEGPPQ-NCVTGNITGKSFSI 324

Query: 977  KWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEA 1036
             W   +  T       Y ++L   + R +         +    LT FT Y   I A + A
Sbjct: 325  LW---DPPTIVTGKFSYRVELYGPSGRILD-NSTKDLKFAFTNLTPFTMYDVYIAAETSA 380

Query: 1037 GEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLV 1093
            G GP S    F T   VP  +   ++ ++E     I W+      G    Y ++VLV
Sbjct: 381  GTGPKSNISVF-TPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLV 436



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 175/882 (19%), Positives = 302/882 (34%), Gaps = 114/882 (12%)

Query: 286  NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDL 345
            NI  ++  + W PP        + ++  +SY V L   G  G+  +  S ++L+    +L
Sbjct: 316  NITGKSFSILWDPP--------TIVTGKFSYRVELY--GPSGRI-LDNSTKDLKFAFTNL 364

Query: 346  RPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDN 405
             P T Y V + A  ++  G  S  +S  T    P   F  +LA    + + + WK P   
Sbjct: 365  TPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQP 423

Query: 406  GSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQE 465
               I  Y                        ++  L P  G           G + Y  +
Sbjct: 424  NGIINQY------------------------RVKVLVPETGIILENTLLT--GNNEYIND 457

Query: 466  VVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP-EEVITYTLEIQEDEN------ 518
                        P AP +V      V L     E  S    + T+      D+N      
Sbjct: 458  ------------PMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNR 505

Query: 519  -----------DNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
                        N +      E L+  ++ L   T++   ++A    G+  P+ + V T 
Sbjct: 506  AEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTR 565

Query: 568  SPDRPGPPTRPLVKGP-VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS 626
               +  P +  ++    ++S    + WDPP+   G +I  Y +   + ++          
Sbjct: 566  ---QQVPSSIKIINYKNISSSSILLYWDPPEYPNG-KITHYTIYAMELDTNRAFQITTID 621

Query: 627  GSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES--LPVRTLSIAPGQCRPPRVLGRPK 684
             S   +  T LK  T YK+R    +  G S  SE   + VRT    P        +    
Sbjct: 622  NS---FLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVT 678

Query: 685  HKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVR 744
              E+ L+W  P   +G  ++ Y V     + +  +  +    +  + NL P T+Y   VR
Sbjct: 679  ADEIRLKWSPPEKPNGIIIA-YEVLYKNIDTLYMK--NTSTTDIILRNLRPHTLYNISVR 735

Query: 745  ALNDGGYGPY--SDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRL 802
            +    G+G    S +S  T+   P    +         G + + +  P S    I +Y +
Sbjct: 736  SYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTI 795

Query: 803  EWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPD 862
                   + E   + T     I+ L    QY   + A    G G  S  +   T   APD
Sbjct: 796  YLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 855

Query: 863  PVSTLCVLEEEPLDAYPDSPSACLV-LNWEEPCNNGSEILAYTIDLGDTS----ITVGNT 917
                       P D      S   V L+W+ P      IL YT+ + + S    I V  T
Sbjct: 856  ---------SPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTET 906

Query: 918  TMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP--LPPLPPR-LECAAAGPQSL 974
            ++  + DL     Y   + A    G G     I +   P   P  PP+ +  A     S+
Sbjct: 907  SLE-LSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSI 965

Query: 975  KLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYK---------VQRLTEFTC 1025
             L W   +      +   Y++   + +  F+  +     T           + +LT F+ 
Sbjct: 966  ILFWTPPSKPNGIIQ--YYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSY 1023

Query: 1026 YSFRIQAASEAGEG-PFSETYTFSTTKSVPPTIKAPRVTQ-LEGNSCEILWETVPSMKGD 1083
            Y+F + A++  G G   S+     T + +P         + +   +  + W       G 
Sbjct: 1024 YTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGL 1083

Query: 1084 PVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRV 1125
               Y+  +L       +      E +     L+  TDY  ++
Sbjct: 1084 VFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKI 1125



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 97/441 (21%), Positives = 157/441 (35%), Gaps = 76/441 (17%)

Query: 425 FRQCFFG-SQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRL 483
           F   F G S+    ++ + P   Y   +++   I T+ Y+  V      N+ + P  P  
Sbjct: 7   FLLLFIGTSETQVDVSNVVPGTRYDITISS---ISTT-YTSPVTRIVTTNVTK-PGPPVF 61

Query: 484 V---RAGITWVTLQWSKPEGCSPEEVITYTLEIQED---ENDNLFHPKYTGEDLTCTVKN 537
           +   R G   + L W+ P   +   +I+Y ++ +E            +   + L   + N
Sbjct: 62  LAGERVGSAGILLSWNTPPNPNGR-IISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTN 120

Query: 538 LKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGP--------------------PTR 577
           L   T Y+ ++ A N+ G    S+  +  T+   PG                     P +
Sbjct: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQ 180

Query: 578 PLVKGPVTSHGFSVKWDPP----KDNG--GSEILKYLLEITDGNSEANQWEVA------- 624
           P   G +TS   SVK        KD      +IL   L   + NSE+  W  A       
Sbjct: 181 P--NGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLG 238

Query: 625 ---------YSGSA-------------TEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662
                    +S S                +  THL+P T Y       +T   +   +S 
Sbjct: 239 RVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATT--EAGYIDST 296

Query: 663 PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH 722
            VRT    P       V G    K   + WD P   +G     Y VE+  P     +   
Sbjct: 297 IVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTG--KFSYRVELYGPSGRILD-NS 353

Query: 723 GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC 782
             +L+    NL P T+Y   + A    G GP S++S + T    PG      ++      
Sbjct: 354 TKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNIS-VFTPPDVPGAVFDLQLAEVESTQ 412

Query: 783 VLVGWESPDSSGADISEYRLE 803
           V + W+ P      I++YR++
Sbjct: 413 VRITWKKPRQPNGIINQYRVK 433



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 73/332 (21%), Positives = 123/332 (37%), Gaps = 82/332 (24%)

Query: 813  LIYHGT-DTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLE 871
            L++ GT +T+ ++ +++P  +Y   + + +     P + +V   T  + P P   L    
Sbjct: 9    LLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVT--TNVTKPGPPVFL---- 62

Query: 872  EEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD---------TSITVGNTTMHVM 922
                 A     SA ++L+W  P N    I++Y +   +         T +     ++ V+
Sbjct: 63   -----AGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVL 117

Query: 923  -KDLLPETTYRIRIQAINEIGAGPFSQ-FIKAKTRPLPPLPPRLECAAAGPQSLKLKW-- 978
              +L P TTY I++ A N  G G FS  F+       P     L   A    ++KL W  
Sbjct: 118  LTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYL 177

Query: 979  -GDSNSK--------THAAEDIV---YTLQLED-----------RNKRFISIYRGPSHT- 1014
                N K         HA   IV    ++++ED            ++ F+     PS T 
Sbjct: 178  PRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTL 237

Query: 1015 ------------------------------YKVQRLTEFTCYSFRIQAASEAGEGPFSET 1044
                                          + V  L  +T Y F + AA+   E  + ++
Sbjct: 238  GRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATT--EAGYIDS 295

Query: 1045 YTFSTTKSVPPTIKAPRVT-QLEGNSCEILWE 1075
                T +SVP       VT  + G S  ILW+
Sbjct: 296  TIVRTPESVPEGPPQNCVTGNITGKSFSILWD 327


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 152/662 (22%), Positives = 245/662 (37%), Gaps = 67/662 (10%)

Query: 449  FRLAARNDIGTSGYSQEVVCY--TLGNIPQMPSAPR---LVRAGITWVTLQWSKP-EGCS 502
            ++  A N+ G +  S +++     + +   +PSAPR    V     +V L W  P E   
Sbjct: 398  YQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKG 457

Query: 503  PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 562
              +  T     + D  +   +    G  L  TV NLK    Y FR+ A N  G    S+ 
Sbjct: 458  NIQTFTVFFSREGDNRERALNTTQPGS-LQLTVGNLKPEAMYTFRVVAYNEWGPGESSQP 516

Query: 563  LVCTTSPDRPGP-PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
            +   T P+   P P   L     +     + W+PP    G  +  Y L  T+ ++   Q 
Sbjct: 517  IKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGP-VQGYRLFCTEVSTGKEQ- 574

Query: 622  EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
             +   G +  Y    LK  T Y LR    +  G    ++ + V TLS  P        L 
Sbjct: 575  NIEVDGLS--YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLE 632

Query: 682  RPKHKEVHLEWDVPAS--ESGCEVSEYSVEMTEPEDVAS-EVYHGPELECTVGNLLPGTV 738
                + + + W  P S  ++G  ++ Y +   +       E      L      L  G+ 
Sbjct: 633  VVNSRSIKVSWLPPPSGTQNGF-ITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQ 691

Query: 739  YRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAP----CISCTPD-GCVLVGWESPDSS 793
            Y F+V A+   G GP S+     T      + + P     +   P   C+++ W  P + 
Sbjct: 692  YSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNP 751

Query: 794  GADISEYRLEWGEDEESLELIYHGTDTRF-EIRDLLPAAQYCCRLQAFNQAGAG-PYSEL 851
               +  Y + +G      E +   +  R+  I  L  ++ Y   L+AFN AG G P  E 
Sbjct: 752  NIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811

Query: 852  VLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLV---------------LNWEE---P 893
               ++     DPV    +L++ P    PD  +  L                ++W +   P
Sbjct: 812  ATTRSITDPTDPVDYYPLLDDFPTSV-PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVP 870

Query: 894  CNNG-SEILAYTIDLGDTSITVG--------NTTMHVMKDLLPETTYRIRIQAINEIGAG 944
             N   SE+  YT+    TS +           +  +    L P T Y   +       + 
Sbjct: 871  KNQKTSEVRLYTVRWR-TSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSS 929

Query: 945  PFSQFIKAKTRPLPPLPPRLECAA----AGPQSLKLKWG---DSNSKTHAAEDIVYTLQ- 996
             +S    A T    P     +         P+++ + W    ++N K   A  + YTL  
Sbjct: 930  TWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKI-TAYILFYTLDK 988

Query: 997  ---LEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSV 1053
               ++D     IS   G   T+++  L   T Y FRIQA +  G GP S+   F T K  
Sbjct: 989  NIPIDDWIMETIS---GDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045

Query: 1054 PP 1055
             P
Sbjct: 1046 HP 1047



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 138/632 (21%), Positives = 226/632 (35%), Gaps = 92/632 (14%)

Query: 287  IQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGE--ELECNLKD 344
            + +R V LSW PP        +       + V  S +G D + + + + +   L+  + +
Sbjct: 440  VSSRFVRLSWRPPAEAKGNIQT-------FTVFFSREG-DNRERALNTTQPGSLQLTVGN 491

Query: 345  LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH-----RSKSSLTLQW 399
            L+P   Y  RV A      G  S+P+   T    PE   P  + +      S +S+ + W
Sbjct: 492  LKPEAMYTFRVVAYNEWGPGESSQPIKVATQ---PELQVPGPVENLQAVSTSPTSILITW 548

Query: 400  KAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT 459
            + P      +  Y L   E   ++G  Q         KL  L     Y+ R  A N  G 
Sbjct: 549  EPPAYANGPVQGYRLFCTE--VSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGP 606

Query: 460  SGYSQEVVCYTLGNIPQMPSAPRLVRAGIT---WVTLQWSKPEGCSPEEVIT-YTL---- 511
               + ++   TL ++P  P  P+ V   +     + + W  P   +    IT Y +    
Sbjct: 607  GVSTDDITVVTLSDVPSAP--PQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRK 664

Query: 512  -----EIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT 566
                 E++  E +NL++  +TG         L++ +QY F+++A    G   PS      
Sbjct: 665  TTRRGEMETLEPNNLWY-LFTG---------LEKGSQYSFQVSAMTVNGTGPPSNWYTAE 714

Query: 567  TSP---DRPGPPTRP--LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
            T     D    P +P  L   P T +   + W PP  N    +  Y++    G+  A   
Sbjct: 715  TPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPL-NPNIVVRGYIIGYGVGSPYAE-- 770

Query: 622  EVAYSGSATEYTFTHLKPGTLYKLRACCISTGG----------------------HSQCS 659
             V        Y+   L+  + Y +     +  G                      +    
Sbjct: 771  TVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLL 830

Query: 660  ESLPVRTLSIAPGQCRPPRVLG-RPKHKEVHLEW---DVPASESGCEVSEYSVEMTEPED 715
            +  P     ++     P  V      H  V + W    VP ++   EV  Y+V       
Sbjct: 831  DDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRW-RTSF 889

Query: 716  VASEVYHGPE---LECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKA 772
             AS  Y   +   L  T   L P T+Y F V    +     +S  +  TT    P     
Sbjct: 890  SASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPK 949

Query: 773  PCISCTPDG---CVLVGWESPDSSGADISEYRLEWGED-----EESLELIYHGTDTRFEI 824
                 T +G    V+V W+ P  +   I+ Y L +  D     ++ +     G     +I
Sbjct: 950  DLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQI 1009

Query: 825  RDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT 856
             DL     Y  R+QA N  G GP S+ +L +T
Sbjct: 1010 MDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 131/626 (20%), Positives = 217/626 (34%), Gaps = 87/626 (13%)

Query: 391  SKSSLTLQWKAPIDNGSKITNYLLEWD-EGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTF 449
            S   + L W+ P +    I  + + +  EG                  +  L P   YTF
Sbjct: 441  SSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTF 500

Query: 450  RLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA---GITWVTLQWSKPEGCSP--E 504
            R+ A N+ G    SQ +   T   + Q+P     ++A     T + + W  P   +   +
Sbjct: 501  RVVAYNEWGPGESSQPIKVATQPEL-QVPGPVENLQAVSTSPTSILITWEPPAYANGPVQ 559

Query: 505  EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLV 564
                +  E+   +  N+       + L+  ++ LK+ T+Y  R  A N  G    ++ + 
Sbjct: 560  GYRLFCTEVSTGKEQNI-----EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDIT 614

Query: 565  CTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPP---KDNGGSEILKYLLEITDGNSEANQW 621
              T  D P  P + +    V S    V W PP     NG     K     T    E    
Sbjct: 615  VVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETL 674

Query: 622  EVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE----SLPVRTLSIAPGQCRPP 677
            E     +   Y FT L+ G+ Y  +   ++  G    S       P   L  +    +P 
Sbjct: 675  E----PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPS 730

Query: 678  RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV-YHGPELECTVGNLLPG 736
             +  RP+   + + W  P + +   V  Y +        A  V     +   ++  L   
Sbjct: 731  SLHVRPQTNCIIMSWTPPLNPN-IVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESS 789

Query: 737  TVYRFRVRALNDGG----------------------YGPYSD-----VSEITTAAGPPGQ 769
            + Y   ++A N+ G                      Y P  D     V +++T   PP  
Sbjct: 790  SHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVG 849

Query: 770  CKAPCISCTPDGCVLVGWES----PDSSGADISEYRLEWGEDEESLELIYHGTDT---RF 822
             +A  ++ T D  V V W       +   +++  Y + W     S    Y   DT    +
Sbjct: 850  VQA--VALTHD-AVRVSWADNSVPKNQKTSEVRLYTVRW-RTSFSASAKYKSEDTTSLSY 905

Query: 823  EIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT----PASAPDPVSTLCVLEEEPLDAY 878
                L P   Y   +       +  +S      T    P SAP  + T+   E +P    
Sbjct: 906  TATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDL-TVITREGKP---- 960

Query: 879  PDSPSACLVLNWEEPCNNGSEILAYTIDLG-DTSITV---------GNTTMHVMKDLLPE 928
                   ++++W+ P     +I AY +    D +I +         G+   H + DL  +
Sbjct: 961  -----RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLD 1015

Query: 929  TTYRIRIQAINEIGAGPFSQFIKAKT 954
            T Y  RIQA N  G GP S  I  +T
Sbjct: 1016 TMYYFRIQARNSKGVGPLSDPILFRT 1041



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 33/134 (24%), Positives = 54/134 (40%), Gaps = 8/134 (5%)

Query: 345  LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS----SLTLQWK 400
            L+P T Y   V    N    + S     TT+  AP    P  L   ++     ++ + W+
Sbjct: 910  LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSA-PKDLTVITREGKPRAVIVSWQ 968

Query: 401  APIDNGSKITNYLLEWDEGKR---NSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
             P++   KIT Y+L +   K    +    +   G +   ++  L     Y FR+ ARN  
Sbjct: 969  PPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSK 1028

Query: 458  GTSGYSQEVVCYTL 471
            G    S  ++  TL
Sbjct: 1029 GVGPLSDPILFRTL 1042


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 162/739 (21%), Positives = 268/739 (36%), Gaps = 80/739 (10%)

Query: 283  QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELE-CN 341
            ++ +++AR + L W      +  P +G    Y  E        D   +      +L    
Sbjct: 892  EIKDVKARTITLRWTMGFDGN-SPITG----YDIECKNKSDSWDSAQRTKDVSPQLNSAT 946

Query: 342  LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHR---SKSSLTLQ 398
            + D+ P++ Y +R+YA     K   S  ++ T    AP+   PP+  H    S  S+ + 
Sbjct: 947  IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD--GPPQEVHLEPISSQSIRVT 1004

Query: 399  WKAP---IDNGSKITNYLLEWDEGKRNSGFRQCFF-----GSQKHCKLTKLCPAMGYTFR 450
            WKAP   + NG  I  Y + + E      F+         G  +   L  L     Y   
Sbjct: 1005 WKAPKKHLQNGI-IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063

Query: 451  LAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA--------GITWVTLQWSKPEGCS 502
            + A N  GT   SQE++  TL ++P  P  P  V+A         I+W TL      G  
Sbjct: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYP--PENVQAIATSPESISISWSTLSKEALNGIL 1121

Query: 503  PEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 562
                + Y   + + E   + +   T   L   +  L++ T Y  ++ A    G    SE 
Sbjct: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSL--ELDGLEKYTNYSIQVLAFTRAGDGVRSEQ 1179

Query: 563  LVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWE 622
            +   T  D PGPP          S  F V W PP    G  I KY +  +         E
Sbjct: 1180 IFTRTKEDVPGPPAGVKAAAASASMVF-VSWLPPLKLNGI-IRKYTVFCSHPYPTVIS-E 1236

Query: 623  VAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRP-PRVLG 681
               S  +  Y   +L     Y +    +++ G    SE + V  L+ AP +       + 
Sbjct: 1237 FEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVT 1296

Query: 682  RPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV-YHGPELECTVGNLLPGTVYR 740
             P  K++ L    P    G + S     M +     S V   G     + G+ +  TV  
Sbjct: 1297 TPWMKDIVL----PCKAVG-DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV-- 1349

Query: 741  FRVRALNDGGYGPYSDVSEITTAAG----------PPGQCKAPCISCTPDGCVLVGWESP 790
                   D GY  YS ++     +           PP Q +   +S T    + + W   
Sbjct: 1350 ----KAEDSGY--YSCIANNNWGSDEIILNLQVQVPPDQPRL-TVSKTTSSSITLSWLPG 1402

Query: 791  DSSGADISEYRLEWGED--EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
            D+ G+ I  Y L++ ED  E+        ++  + + +L     Y   L A N  G G  
Sbjct: 1403 DNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRI 1462

Query: 849  SELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL-VLNWEEPCNNGSEILAYTIDL 907
            SE++  +T    P         +E+ L A  ++    L ++ W +    G  I ++T++ 
Sbjct: 1463 SEIIEAKTLGKEPQ------FSKEQELFASINTTRVRLNLIGWND---GGCPITSFTLEY 1513

Query: 908  GDTSITVGNTTM-------HVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960
                 TV  T         +++ DL   T Y ++++  N  G                 +
Sbjct: 1514 RPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573

Query: 961  PPRLECAAAGPQSLKLKWG 979
            PP ++      + L    G
Sbjct: 1574 PPLIKSVVQNEEGLTTNEG 1592



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 144/594 (24%), Positives = 226/594 (38%), Gaps = 49/594 (8%)

Query: 491  VTLQWSKP-EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDL-TCTVKNLKRSTQYKFRL 548
            +TL+W+   +G SP        + + D  D+    K     L + T+ ++  S+ Y  R+
Sbjct: 901  ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960

Query: 549  TASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILK-- 606
             A N  GKS PS  L  T     P  P + +   P++S    V W  PK +  + I++  
Sbjct: 961  YAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020

Query: 607  ---YLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP 663
               Y    T GN + N   V  SG +  YT  +L   T Y L     +  G    S+ + 
Sbjct: 1021 QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080

Query: 664  VRTLSIAPGQCRPPRVLG--RPKHKEVHLEWDVPASES------GCEVSEYSVEMT-EPE 714
              TL   P    PP  +       + + + W   + E+      G  V  ++  M  E  
Sbjct: 1081 TTTLEDVPSY--PPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELG 1138

Query: 715  DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT---AAGPPGQCK 771
            ++ +     P LE  +  L   T Y  +V A    G G  S+     T     GPP   K
Sbjct: 1139 EIKNITTTQPSLE--LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK 1196

Query: 772  APCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIR--DLLP 829
            A   S +    V V W  P      I +Y +       ++   +  +   F  R  +L  
Sbjct: 1197 AAAASAS---MVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSR 1253

Query: 830  AAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLN 889
              QY   + A   AG G  SE++  +  A AP  + T       P     D    C  + 
Sbjct: 1254 NRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW--MKDIVLPCKAVG 1311

Query: 890  WEEPC------NNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
               P       +NG+  L  TID G  SI    +   +++ +  E +      A N  G+
Sbjct: 1312 DPSPAVKWMKDSNGTPSLV-TID-GRRSIFSNGS--FIIRTVKAEDSGYYSCIANNNWGS 1367

Query: 944  GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKW--GDSNSKTHAAEDIVYTLQLEDRN 1001
                + I      +PP  PRL  +     S+ L W  GD+   +     + Y+   ED +
Sbjct: 1368 ---DEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS---EDNS 1421

Query: 1002 KRFISIYRGPS-HTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVP 1054
            +++ S    PS  +Y+++ L   T Y F + A +  G G  SE     T    P
Sbjct: 1422 EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEP 1475



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 91/415 (21%), Positives = 154/415 (37%), Gaps = 47/415 (11%)

Query: 676  PPRV-LGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH----GPELE-CT 729
            PP + +   K + + L W +   +    ++ Y +E     D            P+L   T
Sbjct: 888  PPEIEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSAT 946

Query: 730  VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT-AAGPPGQCKAPCISCTPDGCVLVGWE 788
            + ++ P + Y  R+ A N  G    S+   IT   A P G  +   +       + V W+
Sbjct: 947  IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWK 1006

Query: 789  SPDS--SGADISEYRLEWGEDEESLELIYH-------GTDTRFEIRDLLPAAQYCCRLQA 839
            +P        I  Y++ + E        ++       G    + + +L    QY   +QA
Sbjct: 1007 APKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066

Query: 840  FNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW----EEPCN 895
             N+AG GP S+ ++  T    P           E + A   SP + + ++W    +E  N
Sbjct: 1067 CNRAGTGPSSQEIITTTLEDVPS-------YPPENVQAIATSPES-ISISWSTLSKEALN 1118

Query: 896  N---GSEILAYTI----DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
                G  ++ +      +LG+            +  L   T Y I++ A    G G  S+
Sbjct: 1119 GILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178

Query: 949  FIKAKTRPLPPLPPR-LECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI 1007
             I  +T+   P PP  ++ AAA    + + W              YT+         IS 
Sbjct: 1179 QIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRK--YTVFCSHPYPTVISE 1236

Query: 1008 YRGP--SHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP 1060
            +     S +Y++  L+    YS  + A + AG G  SE  T      V P  KAP
Sbjct: 1237 FEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT------VEPLAKAP 1285



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 64/305 (20%), Positives = 122/305 (40%), Gaps = 40/305 (13%)

Query: 833  YCCRLQAFNQAGAGPYSELVLC-QTPASAPD-PVSTLCVL---EEEPLDAYPDSPSACLV 887
            Y C++   N  GA     + L  + PA     P +TL      +E    A+ + P   ++
Sbjct: 764  YLCKVS--NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKP---II 818

Query: 888  LNWEEPCN----NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGA 943
            + WE+         +  L  T ++G+  I+    T+ ++  +  ++ +     AIN  G 
Sbjct: 819  VRWEKEDRIINPEMARYLVSTKEVGEEVIS----TLQILPTVREDSGF-FSCHAINSYGE 873

Query: 944  GPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG---DSNSKTHAAEDIVYTLQLEDR 1000
                + I   T   PP PP +E      +++ L+W    D NS         Y ++ +++
Sbjct: 874  ---DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITG-----YDIECKNK 925

Query: 1001 NKRFISIYRGPSHTYKVQRLT-----EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPP 1055
            +  + S  R    + ++   T       + YS R+ A +  G+   S   T +  ++ P 
Sbjct: 926  SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD 985

Query: 1056 TIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGL 1115
                P+   LE  S + +  T  + K    N I++   G +  Y++   G    F I  +
Sbjct: 986  --GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIR---GYQIGYREYSTGGNFQFNIISV 1040

Query: 1116 QTNTD 1120
             T+ D
Sbjct: 1041 DTSGD 1045


>gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]
          Length = 1326

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 137/565 (24%), Positives = 215/565 (38%), Gaps = 70/565 (12%)

Query: 511  LEIQEDENDNLFHPKYTGEDLTC-TVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSP 569
            +E+ E+E  ++      GED    T+ N  R       L   N  G +  +  L      
Sbjct: 646  MEVTEEERVSMER----GEDQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVL--- 698

Query: 570  DRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSA 629
            DRP PP   +    ++     +KW  PKDNGG  + ++++E      ++        G  
Sbjct: 699  DRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKV 758

Query: 630  TEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQ-CRPPRVLGRPKHKEV 688
            T ++   ++ G  Y+ R   +++ G S      P+ T  +  G    PP    +P+  +V
Sbjct: 759  TNFSTNKVEEGKAYQFRILAVNSEGVSD-----PLETEEVFAGNPIEPPGFASQPQVTDV 813

Query: 689  HLE-----WDVPASESGCEVSEYSVEMTEPED-----VASEVYHGPELECTVGNLLPGTV 738
              E     W+ P  + G  V  Y VE  +        V  +   G +  CTV  LL  T 
Sbjct: 814  TKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQGTK--CTVDGLLEDTE 871

Query: 739  YRFRVRALNDGGYGPYSDVSEITTA---AGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
            Y FRV A+N  G G  S  S    A     PPG  +   +S + +  + + W  P + G 
Sbjct: 872  YEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDSSNSSISLAWREP-AEGD 930

Query: 796  DISEYRLEW-GED--EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSEL- 851
              S Y LE   ED  E S       + T + +  L+   +Y  R++A N+AG G   EL 
Sbjct: 931  PPSGYILEMRAEDTKEWSKCTKIPISGTCYTVGGLIERQKYFFRIRAVNEAGVGEPVELD 990

Query: 852  --VLCQTPASAPD--------------PVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCN 895
              V    P +AP                 + LC+       A+  SP   ++   +    
Sbjct: 991  KGVRAMPPPAAPKFDLSARLKSHMVVRAGTALCIHA-----AFSGSPPPDVIWQKDGVPT 1045

Query: 896  NGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTR 955
             G E +  T     +   + +T             YRI +Q  NE G   +   ++    
Sbjct: 1046 KGRETI--TKSKNHSQFLINSTKRS------DSGVYRILLQ--NEFGEARYDIHVRVADF 1095

Query: 956  PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKR--FISIYRGPSH 1013
            P PP   RL      P ++ L W  S       E   Y +   D +    + +  R  S+
Sbjct: 1096 PRPPTNLRL--FEEVPNTVTLTWNHSPDVQEDGE-AHYIIMKRDASTATWYTAAERVFSN 1152

Query: 1014 TYKVQRLTEFTCYSFRIQAASEAGE 1038
             Y V  L     Y FR+ A +E G+
Sbjct: 1153 KYTVTGLLPGRKYYFRVVARNEIGD 1177



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 106/490 (21%), Positives = 187/490 (38%), Gaps = 55/490 (11%)

Query: 675  RPPRVLGRPKHKE-----VHLEWDVPASESGCEVSEYSVE---MTEPEDVASEVYHGPEL 726
            RP    GR +  E     VH++W  P    G  V+++ VE   + +   +      G   
Sbjct: 700  RPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKVT 759

Query: 727  ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA--AGPPGQCKAPCISCTPDGCVL 784
              +   +  G  Y+FR+ A+N  G     +  E+       PPG    P ++      V 
Sbjct: 760  NFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFASQPQVTDVTKEAVT 819

Query: 785  VGWESP-DSSGADISEYRLEWGEDEESLELIYHGTD---TRFEIRDLLPAAQYCCRLQAF 840
            + W +P    GA +  Y +E  +   +L +  +      T+  +  LL   +Y  R+ A 
Sbjct: 820  ITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQGTKCTVDGLLEDTEYEFRVIAV 879

Query: 841  NQAGAGPYS---ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNG 897
            N+AG G  S     V+ + P   P  V  L V          DS ++ + L W EP   G
Sbjct: 880  NKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHV---------SDSSNSSISLAWREPAE-G 929

Query: 898  SEILAYTIDLGD---------TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
                 Y +++           T I +  T  + +  L+    Y  RI+A+NE G G   +
Sbjct: 930  DPPSGYILEMRAEDTKEWSKCTKIPISGTC-YTVGGLIERQKYFFRIRAVNEAGVGEPVE 988

Query: 949  FIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAA------EDIVYTLQLEDRNK 1002
              K      PP  P+ + +A     + ++ G +    HAA       D+++         
Sbjct: 989  LDKGVRAMPPPAAPKFDLSARLKSHMVVRAGTALC-IHAAFSGSPPPDVIWQKDGVPTKG 1047

Query: 1003 RFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR 1061
            R  +I +  +H+ + +          +RI   +E GE  +      +     P  +   R
Sbjct: 1048 R-ETITKSKNHSQFLINSTKRSDSGVYRILLQNEFGEARYDIHVRVADFPRPPTNL---R 1103

Query: 1062 VTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQ----ISGLQT 1117
            + +   N+  + W   P ++ D   +   +++ R++     Y   E  F     ++GL  
Sbjct: 1104 LFEEVPNTVTLTWNHSPDVQEDGEAH--YIIMKRDASTATWYTAAERVFSNKYTVTGLLP 1161

Query: 1118 NTDYRFRVCA 1127
               Y FRV A
Sbjct: 1162 GRKYYFRVVA 1171



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 68/255 (26%), Positives = 107/255 (41%), Gaps = 23/255 (9%)

Query: 373 TTHSCAPECPFPPK----LAHRSKSSLTLQWKAPIDNGSK-ITNYLLEWDEGKRNSGFRQ 427
           T H    + P PP+        S S + ++WKAP DNG + +T +++E    +R  G + 
Sbjct: 692 TLHLSVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVE----RRAVGKKS 747

Query: 428 CFFGSQKHCKLT-----KLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSA 480
                +   K+T     K+     Y FR+ A N  G S    ++EV        P   S 
Sbjct: 748 WIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFASQ 807

Query: 481 PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHP--KYTGEDLTCTVKNL 538
           P++       VT+ W+ P       V+ Y +E +  +  NL+ P  K   +   CTV  L
Sbjct: 808 PQVTDVTKEAVTITWNAPTQDGGAPVLGYIVE-RRKKGSNLWVPVNKDPIQGTKCTVDGL 866

Query: 539 KRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPP--TRPLVKGPVTSHGFSVKWDPP 596
              T+Y+FR+ A N  G   PS       + D   PP   + L     ++   S+ W  P
Sbjct: 867 LEDTEYEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDSSNSSISLAWREP 926

Query: 597 KDNGGSEILKYLLEI 611
            +  G     Y+LE+
Sbjct: 927 AE--GDPPSGYILEM 939



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 93/406 (22%), Positives = 153/406 (37%), Gaps = 54/406 (13%)

Query: 281  KPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSG-EELE 339
            +PQV+++   AV ++W  P      P  G      Y V    KG +    +     +  +
Sbjct: 807  QPQVTDVTKEAVTITWNAPTQDGGAPVLG------YIVERRKKGSNLWVPVNKDPIQGTK 860

Query: 340  CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL------AHRSKS 393
            C +  L   T+Y  RV A+  +  G  S P S      A +   PP L      +  S S
Sbjct: 861  CTVDGLLEDTEYEFRVIAVNKAGPGQPSVPSSSVV---AKDPVKPPGLVQDLHVSDSSNS 917

Query: 394  SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMG------- 446
            S++L W+ P + G   + Y+LE    +    + +C         ++  C  +G       
Sbjct: 918  SISLAWREPAE-GDPPSGYILEM-RAEDTKEWSKC-----TKIPISGTCYTVGGLIERQK 970

Query: 447  YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR-----------LVRAGITWVTLQW 495
            Y FR+ A N+ G  G   E+        P  P+AP+           +VRAG        
Sbjct: 971  YFFRIRAVNEAGV-GEPVELDKGVRAMPP--PAAPKFDLSARLKSHMVVRAGTALCI--H 1025

Query: 496  SKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
            +   G  P +VI     +     + +   K   + L   + + KRS    +R+   N  G
Sbjct: 1026 AAFSGSPPPDVIWQKDGVPTKGRETITKSKNHSQFL---INSTKRSDSGVYRILLQNEFG 1082

Query: 556  KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGN 615
            +   +   +     D P PPT   +   V  +  ++ W+   D        Y++   D  
Sbjct: 1083 E---ARYDIHVRVADFPRPPTNLRLFEEV-PNTVTLTWNHSPDVQEDGEAHYIIMKRDA- 1137

Query: 616  SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSES 661
            S A  +  A    + +YT T L PG  Y  R    +  G S+  +S
Sbjct: 1138 STATWYTAAERVFSNKYTVTGLLPGRKYYFRVVARNEIGDSEPLDS 1183



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 49/207 (23%), Positives = 80/207 (38%), Gaps = 12/207 (5%)

Query: 933  IRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQSLKLKWG--DSNSKTHAAED 990
            I ++  N+ G+   +  +    RP PP   R+E        + +KW     N      + 
Sbjct: 678  ILLKLKNDHGSATATLHLSVLDRPKPP-QGRVEFLELSGSCVHMKWKAPKDNGGRPVTQF 736

Query: 991  IVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTFST 1049
            IV    +  ++   I    G    +   ++ E   Y FRI A +  G   P      F+ 
Sbjct: 737  IVERRAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAG 796

Query: 1050 TKSVPPTIKA-PRVTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--- 1104
                PP   + P+VT +   +  I W       G PV  YI++      + +  V K   
Sbjct: 797  NPIEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPI 856

Query: 1105 -GEEATFQISGLQTNTDYRFRVCACRR 1130
             G + T  + GL  +T+Y FRV A  +
Sbjct: 857  QGTKCT--VDGLLEDTEYEFRVIAVNK 881


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 94/357 (26%), Positives = 150/357 (42%), Gaps = 41/357 (11%)

Query: 752  GPYSDVSEITTAAGP--PGQCKAPCISCTPDGCVLVGWES--PDSSGADISEYRLEWGED 807
            G    V++IT  + P  PG    P ++      + + W+S  PD     + EY+ +    
Sbjct: 309  GVIEAVAQITVKSLPKAPG---TPMVTENTATSITITWDSGNPDPVSYYVIEYKSK--SQ 363

Query: 808  EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT----PASAPDP 863
            +   ++    T TR+ I  L P ++Y   + A N  G GP SE V+ +T    PASAP  
Sbjct: 364  DGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN 423

Query: 864  VSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLG-DTSITVGNTTMHVM 922
            V    +             +  +++ WEEP      I  Y +    +    VGN   H +
Sbjct: 424  VQARML------------SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 471

Query: 923  KD--------LLPETTYRIRIQAINEIGAGPFSQFIKAKTRP-LPPLPPRLECAAAGPQS 973
             D        LL + TY +R+ A   +G GP S  I+ KT+  +P  P  L   A    S
Sbjct: 472  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 531

Query: 974  LKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAA 1033
            + L W     ++    ++++    E  + R +     P+ +Y V+ L   T Y+FR+ A 
Sbjct: 532  ITLSWSPPRQESIIKYELLFR---EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR 588

Query: 1034 SEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQ 1090
            S  G G F+      T +S+ P  K  +V  +   S  + WE  P     P  Y +Q
Sbjct: 589  SPQGLGAFTPVVRQRTLQSISP--KNFKVKMIMKTSVLLSWE-FPDNYNSPTPYKIQ 642



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 94/380 (24%), Positives = 156/380 (41%), Gaps = 27/380 (7%)

Query: 461 GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
           G  + V   T+ ++P+ P  P +     T +T+ W   +  +P+ V  Y +E +    D 
Sbjct: 309 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSKSQDG 365

Query: 521 LFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTR 577
            +  K   ED+T T   +  L  +++Y+  ++A N+ G+  PSE +V  T    P    R
Sbjct: 366 PYQIK---EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPR 422

Query: 578 PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFTH 636
            +    +++    V+W+ P +  G  I  Y +  T +       W+      +   T   
Sbjct: 423 NVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 481

Query: 637 LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPA 696
           L     Y +R    ++ G    S+ + V+T    PGQ    R   R     + L W  P 
Sbjct: 482 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPR 540

Query: 697 SESGCEVSEYSVEMTEPEDVASEV--YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPY 754
            ES   + +Y +   E  D   EV     P     V +L P T Y FR+ A +  G G +
Sbjct: 541 QES---IIKYELLFRE-GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAF 596

Query: 755 SD-VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLEL 813
           +  V + T  +  P   K   I  T    VL+ WE PD+  +  + Y++++      L L
Sbjct: 597 TPVVRQRTLQSISPKNFKVKMIMKT---SVLLSWEFPDNYNSP-TPYKIQY----NGLTL 648

Query: 814 IYHGTDTRFEIRDLLPAAQY 833
              G  T+  I  L P   Y
Sbjct: 649 DVDGRTTKKLITHLKPHTFY 668



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 94/383 (24%), Positives = 147/383 (38%), Gaps = 64/383 (16%)

Query: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVA-LSDKGRDGKYKIIYSGEELEC 340
           P V+   A ++ ++W           SG   P SY V     K +DG Y+I         
Sbjct: 329 PMVTENTATSITITW----------DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 378

Query: 341 NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAP-ECPFPPKLAHRSKSSLTLQW 399
           ++  L P ++Y + V A+ +  +G  SE V   T   AP   P   +    S +++ +QW
Sbjct: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438

Query: 400 KAPIDNGSKITNYLLEWD-EGKRNSGFRQCFFGSQKHCKLTKLCPAMG-------YTFRL 451
           + P++    I  Y + +  E +   G        QKH     L   +G       YT R+
Sbjct: 439 EEPVEPNGLIRGYRVYYTMEPEHPVG------NWQKHNVDDSLLTTVGSLLEDETYTVRV 492

Query: 452 AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
            A   +G    S  +   T   +P  P   R      T +TL WS P     E +I Y L
Sbjct: 493 LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYEL 549

Query: 512 EIQEDENDNLFHPKYTGEDLTCT----VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +E +     H +  G     T    V++LK +T+Y FRL A + +G    +       
Sbjct: 550 LFREGD-----HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFT------- 597

Query: 568 SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS- 626
                 P  R      ++   F VK         S +L +  E  D  +    +++ Y+ 
Sbjct: 598 ------PVVRQRTLQSISPKNFKVKMIMKT----SVLLSW--EFPDNYNSPTPYKIQYNG 645

Query: 627 ------GSATEYTFTHLKPGTLY 643
                 G  T+   THLKP T Y
Sbjct: 646 LTLDVDGRTTKKLITHLKPHTFY 668



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 82/336 (24%), Positives = 135/336 (40%), Gaps = 25/336 (7%)

Query: 368 EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
           E V+  T    P+ P  P +   + +S+T+ W +   N   ++ Y++E+    ++  ++ 
Sbjct: 312 EAVAQITVKSLPKAPGTPMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQI 369

Query: 428 CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA- 486
               +     +  L P   Y   ++A N IG    S+ VV  T    P   SAPR V+A 
Sbjct: 370 KEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP--ASAPRNVQAR 427

Query: 487 --GITWVTLQWS---KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
               T + +QW    +P G      + YT+E +    +  +      + L  TV +L   
Sbjct: 428 MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN--WQKHNVDDSLLTTVGSLLED 485

Query: 542 TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y  R+ A  + G    S+ +   T    PG P   L     +    ++ W PP+    
Sbjct: 486 ETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN-LRAEARSETSITLSWSPPRQ--- 541

Query: 602 SEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             I+KY L   +G+   +  EV  +    T Y    LKP T Y  R    S  G    + 
Sbjct: 542 ESIIKYELLFREGD---HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 598

Query: 661 SLPVRTL-SIAPGQCRPPRVLGRPKHKEVHLEWDVP 695
            +  RTL SI+P   +   ++       V L W+ P
Sbjct: 599 VVRQRTLQSISPKNFKVKMIM----KTSVLLSWEFP 630



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 75/307 (24%), Positives = 113/307 (36%), Gaps = 42/307 (13%)

Query: 264 EYELEVKRVQDILSGIEKPQV-------------SNIQAR-----AVVLSWAPPVGLSCG 305
           EYE+ V  V  I  G     V              N+QAR      +++ W  PV     
Sbjct: 388 EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV----- 442

Query: 306 PHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGS 365
             +GL   Y     +  +   G ++     + L   +  L     Y VRV A  +   G 
Sbjct: 443 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502

Query: 366 CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGF 425
            S+P+   T    P  P   +   RS++S+TL W  P      I  Y L + EG      
Sbjct: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKYELLFREGDHGREV 560

Query: 426 RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR 485
            + F  +  +  +  L P   Y FRLAAR+  G   ++  V   TL +I       +++ 
Sbjct: 561 GRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 619

Query: 486 AGITWVTLQWSKPEGC---SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRST 542
              T V L W  P+     +P ++    L +  D           G      + +LK  T
Sbjct: 620 K--TSVLLSWEFPDNYNSPTPYKIQYNGLTLDVD-----------GRTTKKLITHLKPHT 666

Query: 543 QYKFRLT 549
            Y F LT
Sbjct: 667 FYNFVLT 673



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 56/235 (23%), Positives = 98/235 (41%), Gaps = 18/235 (7%)

Query: 917  TTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--PPRLECAAAGPQSL 974
            TT + +  L P + Y I + A+N IG GP S+ +  +T    P   P  ++       ++
Sbjct: 375  TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 434

Query: 975  KLKWGDSNSKTHAAED--IVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
             ++W +            + YT++ E     +       S    V  L E   Y+ R+ A
Sbjct: 435  IVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 494

Query: 1033 ASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVL 1092
             +  G+GP S+     T + VP      R       S  + W   P  +   + Y    L
Sbjct: 495  FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS--PPRQESIIKY---EL 549

Query: 1093 VGRESEY-KQVYKGEEAT--FQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSP 1144
            + RE ++ ++V +  + T  + +  L+ NT+Y FR+ A       S +  GAF+P
Sbjct: 550  LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA------RSPQGLGAFTP 598


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 94/357 (26%), Positives = 150/357 (42%), Gaps = 41/357 (11%)

Query: 752  GPYSDVSEITTAAGP--PGQCKAPCISCTPDGCVLVGWES--PDSSGADISEYRLEWGED 807
            G    V++IT  + P  PG    P ++      + + W+S  PD     + EY+ +    
Sbjct: 305  GVIEAVAQITVKSLPKAPG---TPMVTENTATSITITWDSGNPDPVSYYVIEYKSK--SQ 359

Query: 808  EESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT----PASAPDP 863
            +   ++    T TR+ I  L P ++Y   + A N  G GP SE V+ +T    PASAP  
Sbjct: 360  DGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN 419

Query: 864  VSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLG-DTSITVGNTTMHVM 922
            V    +             +  +++ WEEP      I  Y +    +    VGN   H +
Sbjct: 420  VQARML------------SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 467

Query: 923  KD--------LLPETTYRIRIQAINEIGAGPFSQFIKAKTRP-LPPLPPRLECAAAGPQS 973
             D        LL + TY +R+ A   +G GP S  I+ KT+  +P  P  L   A    S
Sbjct: 468  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 527

Query: 974  LKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAA 1033
            + L W     ++    ++++    E  + R +     P+ +Y V+ L   T Y+FR+ A 
Sbjct: 528  ITLSWSPPRQESIIKYELLFR---EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR 584

Query: 1034 SEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQ 1090
            S  G G F+      T +S+ P  K  +V  +   S  + WE  P     P  Y +Q
Sbjct: 585  SPQGLGAFTPVVRQRTLQSISP--KNFKVKMIMKTSVLLSWE-FPDNYNSPTPYKIQ 638



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 94/380 (24%), Positives = 156/380 (41%), Gaps = 27/380 (7%)

Query: 461 GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 520
           G  + V   T+ ++P+ P  P +     T +T+ W   +  +P+ V  Y +E +    D 
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSKSQDG 361

Query: 521 LFHPKYTGEDLTCT---VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTR 577
            +  K   ED+T T   +  L  +++Y+  ++A N+ G+  PSE +V  T    P    R
Sbjct: 362 PYQIK---EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPR 418

Query: 578 PLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT-DGNSEANQWEVAYSGSATEYTFTH 636
            +    +++    V+W+ P +  G  I  Y +  T +       W+      +   T   
Sbjct: 419 NVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477

Query: 637 LKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPA 696
           L     Y +R    ++ G    S+ + V+T    PGQ    R   R     + L W  P 
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR-SETSITLSWSPPR 536

Query: 697 SESGCEVSEYSVEMTEPEDVASEV--YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPY 754
            ES   + +Y +   E  D   EV     P     V +L P T Y FR+ A +  G G +
Sbjct: 537 QES---IIKYELLFRE-GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAF 592

Query: 755 SD-VSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLEL 813
           +  V + T  +  P   K   I  T    VL+ WE PD+  +  + Y++++      L L
Sbjct: 593 TPVVRQRTLQSISPKNFKVKMIMKT---SVLLSWEFPDNYNSP-TPYKIQY----NGLTL 644

Query: 814 IYHGTDTRFEIRDLLPAAQY 833
              G  T+  I  L P   Y
Sbjct: 645 DVDGRTTKKLITHLKPHTFY 664



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 94/383 (24%), Positives = 147/383 (38%), Gaps = 64/383 (16%)

Query: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVA-LSDKGRDGKYKIIYSGEELEC 340
           P V+   A ++ ++W           SG   P SY V     K +DG Y+I         
Sbjct: 325 PMVTENTATSITITW----------DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 374

Query: 341 NLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAP-ECPFPPKLAHRSKSSLTLQW 399
           ++  L P ++Y + V A+ +  +G  SE V   T   AP   P   +    S +++ +QW
Sbjct: 375 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 434

Query: 400 KAPIDNGSKITNYLLEWD-EGKRNSGFRQCFFGSQKHCKLTKLCPAMG-------YTFRL 451
           + P++    I  Y + +  E +   G        QKH     L   +G       YT R+
Sbjct: 435 EEPVEPNGLIRGYRVYYTMEPEHPVG------NWQKHNVDDSLLTTVGSLLEDETYTVRV 488

Query: 452 AARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTL 511
            A   +G    S  +   T   +P  P   R      T +TL WS P     E +I Y L
Sbjct: 489 LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYEL 545

Query: 512 EIQEDENDNLFHPKYTGEDLTCT----VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTT 567
             +E +     H +  G     T    V++LK +T+Y FRL A + +G    +       
Sbjct: 546 LFREGD-----HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFT------- 593

Query: 568 SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYS- 626
                 P  R      ++   F VK         S +L +  E  D  +    +++ Y+ 
Sbjct: 594 ------PVVRQRTLQSISPKNFKVKMIMKT----SVLLSW--EFPDNYNSPTPYKIQYNG 641

Query: 627 ------GSATEYTFTHLKPGTLY 643
                 G  T+   THLKP T Y
Sbjct: 642 LTLDVDGRTTKKLITHLKPHTFY 664



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 82/336 (24%), Positives = 135/336 (40%), Gaps = 25/336 (7%)

Query: 368 EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQ 427
           E V+  T    P+ P  P +   + +S+T+ W +   N   ++ Y++E+    ++  ++ 
Sbjct: 308 EAVAQITVKSLPKAPGTPMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQI 365

Query: 428 CFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA- 486
               +     +  L P   Y   ++A N IG    S+ VV  T    P   SAPR V+A 
Sbjct: 366 KEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP--ASAPRNVQAR 423

Query: 487 --GITWVTLQWS---KPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRS 541
               T + +QW    +P G      + YT+E +    +  +      + L  TV +L   
Sbjct: 424 MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN--WQKHNVDDSLLTTVGSLLED 481

Query: 542 TQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGG 601
             Y  R+ A  + G    S+ +   T    PG P   L     +    ++ W PP+    
Sbjct: 482 ETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN-LRAEARSETSITLSWSPPRQ--- 537

Query: 602 SEILKYLLEITDGNSEANQWEVAYS-GSATEYTFTHLKPGTLYKLRACCISTGGHSQCSE 660
             I+KY L   +G+   +  EV  +    T Y    LKP T Y  R    S  G    + 
Sbjct: 538 ESIIKYELLFREGD---HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 594

Query: 661 SLPVRTL-SIAPGQCRPPRVLGRPKHKEVHLEWDVP 695
            +  RTL SI+P   +   ++       V L W+ P
Sbjct: 595 VVRQRTLQSISPKNFKVKMIM----KTSVLLSWEFP 626



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 75/307 (24%), Positives = 113/307 (36%), Gaps = 42/307 (13%)

Query: 264 EYELEVKRVQDILSGIEKPQV-------------SNIQAR-----AVVLSWAPPVGLSCG 305
           EYE+ V  V  I  G     V              N+QAR      +++ W  PV     
Sbjct: 384 EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV----- 438

Query: 306 PHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGS 365
             +GL   Y     +  +   G ++     + L   +  L     Y VRV A  +   G 
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498

Query: 366 CSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGF 425
            S+P+   T    P  P   +   RS++S+TL W  P      I  Y L + EG      
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKYELLFREGDHGREV 556

Query: 426 RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVR 485
            + F  +  +  +  L P   Y FRLAAR+  G   ++  V   TL +I       +++ 
Sbjct: 557 GRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 615

Query: 486 AGITWVTLQWSKPEGC---SPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRST 542
              T V L W  P+     +P ++    L +  D           G      + +LK  T
Sbjct: 616 K--TSVLLSWEFPDNYNSPTPYKIQYNGLTLDVD-----------GRTTKKLITHLKPHT 662

Query: 543 QYKFRLT 549
            Y F LT
Sbjct: 663 FYNFVLT 669



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 56/235 (23%), Positives = 98/235 (41%), Gaps = 18/235 (7%)

Query: 917  TTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--PPRLECAAAGPQSL 974
            TT + +  L P + Y I + A+N IG GP S+ +  +T    P   P  ++       ++
Sbjct: 371  TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 430

Query: 975  KLKWGDSNSKTHAAED--IVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQA 1032
             ++W +            + YT++ E     +       S    V  L E   Y+ R+ A
Sbjct: 431  IVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 490

Query: 1033 ASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVL 1092
             +  G+GP S+     T + VP      R       S  + W   P  +   + Y    L
Sbjct: 491  FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS--PPRQESIIKY---EL 545

Query: 1093 VGRESEY-KQVYKGEEAT--FQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSP 1144
            + RE ++ ++V +  + T  + +  L+ NT+Y FR+ A       S +  GAF+P
Sbjct: 546  LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA------RSPQGLGAFTP 594


>gi|140560919 myomesin 1 isoform a [Homo sapiens]
          Length = 1685

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 156/665 (23%), Positives = 246/665 (36%), Gaps = 120/665 (18%)

Query: 378  APECPFPPKLAHRSKSSLTLQWKAP-IDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHC 436
            AP  P   K    +K  + + WK P +D GS I  Y ++  E   +S + QC     K  
Sbjct: 509  APAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDS-WSQCNDTPVKFA 567

Query: 437  K--LTKLCPAMGYTFRLAARNDIG---TSGYSQEVVCY---------------------- 469
            +  +T L     Y FR+ A N +G    S  S+ V                         
Sbjct: 568  RFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIV 627

Query: 470  -----TLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQE--DENDNLF 522
                 + G +P  P+   +  A  ++V L W KP G    E I Y +E  E   EN    
Sbjct: 628  TEEEPSEGIVPGPPTDLSVTEATRSYVVLSW-KPPGQRGHEGIMYFVEKCEAGTENWQRV 686

Query: 523  HPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP--LV 580
            + +   +     + +L     Y FR+  SN+ G   PSE    T   D+   P  P  ++
Sbjct: 687  NTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKII 746

Query: 581  KGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSG--SATEYTFTHLK 638
                T     V W+  KD    E++ Y +E +   S   +WE   +     + +T   L 
Sbjct: 747  PSRNTDTSVVVSWEESKD--AKELVGYYIEASVAGS--GKWEPCNNNPVKGSRFTCHGLV 802

Query: 639  PGTLYKLRACCISTGG---HSQCSESLPVRTL---SIAPGQCRPPRVLGRPKHKEVHLEW 692
             G  Y  R   ++  G   +SQ SE++ V+      ++P  C  P +   P         
Sbjct: 803  TGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGGGVSPDVC--PALSDEPG-------- 852

Query: 693  DVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALND---- 748
                + S   V E S    + + +     + P L  +  NL    V +       +    
Sbjct: 853  --GLTASRGRVHEASPPTFQKDALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPP 910

Query: 749  ------GGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS-SGADISEYR 801
                   G      + + T  A P   C   C+    D  VL GW+ PD   GA+I+ Y 
Sbjct: 911  PQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVL-GWKQPDKIGGAEITGYY 969

Query: 802  LEWGEDEESLELIYHGTDTR------FEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ 855
            + + E  + +   +   + +      ++I +L     Y  ++ A N AG G         
Sbjct: 970  VNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLG--------- 1020

Query: 856  TPASAPDPVSTLCVLEEEPLDAYPDSPSA---------CLVLNWEEPCNNG-SEILAYTI 905
                AP  VS  C   EE   A P  P +          LVL W+ P ++G + +  Y +
Sbjct: 1021 ----APSAVSE-CFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFV 1075

Query: 906  DL-----------GDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF---IK 951
            DL           G     + N  + V + L    +Y  R++AIN+ G G  S     + 
Sbjct: 1076 DLKEAKAKEDQWRGLNEAAIKNVYLKV-RGLKEGVSYVFRVRAINQAGVGKPSDLAGPVV 1134

Query: 952  AKTRP 956
            A+TRP
Sbjct: 1135 AETRP 1139



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 141/649 (21%), Positives = 229/649 (35%), Gaps = 110/649 (16%)

Query: 475  PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLT-C 533
            P  P   + + A   ++ + W +P       ++ Y ++  E   D+      T       
Sbjct: 510  PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569

Query: 534  TVKNLKRSTQYKFRLTASNTEGKSCPS---------------------------EVLVCT 566
             V  L     Y FR+ A N  G   PS                           +++V  
Sbjct: 570  PVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTE 629

Query: 567  TSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
              P     PGPPT   V     S+   + W PP   G   I+ ++ +   G     +   
Sbjct: 630  EEPSEGIVPGPPTDLSVTEATRSY-VVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNT 688

Query: 624  AYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSI------APGQCRPP 677
                 +  +    L  G  Y  R  C ++ G  + SE+  V  +        APG+  P 
Sbjct: 689  ELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIP- 747

Query: 678  RVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEP-----EDVASEVYHGPELECTVGN 732
                R     V + W+   S+   E+  Y +E +       E   +    G    C    
Sbjct: 748  ---SRNTDTSVVVSWE--ESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCH--G 800

Query: 733  LLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDS 792
            L+ G  Y FRVRA+N  G   YS  SE        G         +PD C  +   S + 
Sbjct: 801  LVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGG------GVSPDVCPAL---SDEP 851

Query: 793  SGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELV 852
             G   S  R+         +    G+      +  LP++      Q   Q      SE V
Sbjct: 852  GGLTASRGRVHEASPPTFQKDALLGSKPN---KPSLPSSS-----QNLGQTEVSKVSETV 903

Query: 853  LCQ-TPA---SAPDPVSTLCVLEEEPLDAYPDSPS--ACL-------VLNWEEPCN-NGS 898
              + TP    +AP   S    L+++   A P  P    CL       VL W++P    G+
Sbjct: 904  QEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVLGWKQPDKIGGA 963

Query: 899  EILAYTIDLGDT-----------SITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGP-- 945
            EI  Y ++  +            ++   +   + + +L     Y+ ++ A+N  G G   
Sbjct: 964  EITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPS 1023

Query: 946  -FSQFIKAK--TRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIV--YTLQLEDR 1000
              S+  K +  T  +P  P  L+C+     SL L+W       H+    V  Y + L++ 
Sbjct: 1024 AVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQW---KPPVHSGRTPVTGYFVDLKEA 1080

Query: 1001 NKRFISIYRGPSHT------YKVQRLTEFTCYSFRIQAASEAGEGPFSE 1043
              +    +RG +         KV+ L E   Y FR++A ++AG G  S+
Sbjct: 1081 KAKEDQ-WRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSD 1128



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/582 (23%), Positives = 209/582 (35%), Gaps = 81/582 (13%)

Query: 292  VVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN-----LKDLR 346
            VVLSW PP       H G+     Y V   + G +   ++     EL        L DL 
Sbjct: 654  VVLSWKPPGQRG---HEGIM----YFVEKCEAGTENWQRV---NTELPVKSPRFALFDLA 703

Query: 347  PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKL---AHRSKSSLTLQWKAPI 403
                Y  RV    ++  G  SE    T      + P  P     +  + +S+ + W+   
Sbjct: 704  EGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESK 763

Query: 404  DNGSKITNYLLEWD---EGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
            D   ++  Y +E      GK          GS+  C    L     Y FR+ A N  G S
Sbjct: 764  D-AKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCH--GLVTGQSYIFRVRAVNAAGLS 820

Query: 461  GYSQEV----VCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQED 516
             YSQ+     V   +G        P L             +P G +      +       
Sbjct: 821  EYSQDSEAIEVKAAIGGGVSPDVCPALS-----------DEPGGLTASRGRVHEASPPTF 869

Query: 517  ENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNT----------EGKSCPSEVLVCT 566
            + D L   K     L  + +NL ++   K   T              +GKS  S+ L   
Sbjct: 870  QKDALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKS-KSDPLKKK 928

Query: 567  TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL---EITDGNSEANQWEV 623
            T    P PP   +           + W  P   GG+EI  Y +   E+ DG     +W  
Sbjct: 929  TDRAPPSPPC-DITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDG--VPGKWRE 985

Query: 624  AYSGSATE--YTFTHLKPGTLYKLRACCISTGG---HSQCSESLPVRTLSIA-PGQCRPP 677
            A   + +E  Y  ++LK   +Y+ +   ++  G    S  SE       +IA PG   PP
Sbjct: 986  ANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPG---PP 1042

Query: 678  RVL--GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHG------PELECT 729
              L     +   + L+W  P       V+ Y V++ E +    + + G        +   
Sbjct: 1043 HSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAK-AKEDQWRGLNEAAIKNVYLK 1101

Query: 730  VGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWE- 788
            V  L  G  Y FRVRA+N  G G  SD++    A   PG  K   ++   DG + + +E 
Sbjct: 1102 VRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVAETRPG-TKEVVVNVDDDGVISLNFEC 1160

Query: 789  ---SPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDL 827
               +P S  +   +Y     ED   LE+   G  T+   +DL
Sbjct: 1161 DKMTPKSEFSWSKDYVST--EDSPRLEVESKGNKTKMTFKDL 1200



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 89/386 (23%), Positives = 141/386 (36%), Gaps = 70/386 (18%)

Query: 619 NQW-EVAYSGSATEYTFTHLKPGT--LYKLRACCISTGGH-SQCSESLPVRTLS--IAPG 672
           ++W +  +SG     TF+HL      LY +R   +  G +  Q S  + VR     I   
Sbjct: 453 SKWVQTLWSGERATLTFSHLNKEDEGLYTIR---VRMGEYYEQYSAYVFVRDADAEIEGA 509

Query: 673 QCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYSVEMTEP-EDVASEVYHGPE--LEC 728
              P  V     +K+ + + W  PA + G  +  Y ++  E   D  S+    P      
Sbjct: 510 PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569

Query: 729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP---------------------- 766
            V  L+ G  Y FRVRA+N  G G  S VSE   A  P                      
Sbjct: 570 PVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTE 629

Query: 767 --------PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE----WGEDEESLELI 814
                   PG      ++      V++ W+ P   G +   Y +E      E+ + +   
Sbjct: 630 EEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTE 689

Query: 815 YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP 874
                 RF + DL     YC R++  N AG G  SE       A+    V     + + P
Sbjct: 690 LPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSE-------ATEVTVVGDKLDIPKAP 742

Query: 875 LDAYPD-SPSACLVLNWEEPCNNGSEILAYTID-----------LGDTSITVGNTTMHVM 922
               P  +    +V++WEE   +  E++ Y I+             +  +     T H  
Sbjct: 743 GKIIPSRNTDTSVVVSWEE-SKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCH-- 799

Query: 923 KDLLPETTYRIRIQAINEIGAGPFSQ 948
             L+   +Y  R++A+N  G   +SQ
Sbjct: 800 -GLVTGQSYIFRVRAVNAAGLSEYSQ 824



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 72/341 (21%), Positives = 124/341 (36%), Gaps = 63/341 (18%)

Query: 886  LVLNWEEPC-NNGSEILAYTID---LGDTSITVGNTT-----MHVMKDLLPETTYRIRIQ 936
            ++++W++P  + GS IL Y ID   +G  S +  N T        +  L+   +Y  R++
Sbjct: 526  IIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVR 585

Query: 937  AINEIGAGPFSQF------------IKAKTRP-------------------LPPLPPRLE 965
            A+N++G G  S+              + K+RP                   +P  P  L 
Sbjct: 586  AVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDLS 645

Query: 966  CAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRN----KRFISIYRGPSHTYKVQRLT 1021
               A    + L W     + H  E I+Y ++  +      +R  +     S  + +  L 
Sbjct: 646  VTEATRSYVVLSWKPPGQRGH--EGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLA 703

Query: 1022 EFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPR---VTQLEGNSCEILWETVP 1078
            E   Y FR++ ++ AG G  SE    +         KAP     ++    S  + WE   
Sbjct: 704  EGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESK 763

Query: 1079 SMKGDPVNYILQVLVGRESEYKQVYKG--EEATFQISGLQTNTDYRFRVCACR------- 1129
              K + V Y ++  V    +++       + + F   GL T   Y FRV A         
Sbjct: 764  DAK-ELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEY 822

Query: 1130 ----RCLDTSQELSGAFSPSAAFVLQRSEVMLTGDMGSLDD 1166
                  ++    + G  SP     L      LT   G + +
Sbjct: 823  SQDSEAIEVKAAIGGGVSPDVCPALSDEPGGLTASRGRVHE 863


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 119/501 (23%), Positives = 189/501 (37%), Gaps = 36/501 (7%)

Query: 379 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEW--DEGKRNSGFRQCFFGSQKHC 436
           P  P+       S S++ L W+ P+ N  K+  Y + +   EG  N  ++        H 
Sbjct: 419 PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478

Query: 437 KLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS 496
            +  L PA  YTF + A   +G S  S  V   TL ++P  P    L     T + + W 
Sbjct: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWL 538

Query: 497 K-PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG 555
             P      +V+ Y L  +    +++   +  G      ++ LK  + Y  R+TA+   G
Sbjct: 539 PIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVG 598

Query: 556 KSCPSEVLVCTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEIT 612
               S V     +P       P +  L   P+     SV+W    ++  + I  Y L   
Sbjct: 599 LG-ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAA-IQGYKLYYK 656

Query: 613 DGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLP----VR 665
           +   + N   +        YT + L P   Y +R      I  G  +  + S P    VR
Sbjct: 657 EEGQQEN-GPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVR 715

Query: 666 TLSIAPGQCRPPRVLGRPKH--KEVHLEWDVPASESGCEVSEYSVEMTEP--EDVASEVY 721
              + P    PP  L    +    + L W  PA  +  ++  Y++       ++ +  +Y
Sbjct: 716 DRMVPPPP--PPHHLYAKANTSSSIFLHWRRPAF-TAAQIINYTIRCNPVGLQNASLVLY 772

Query: 722 -HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT----AAGPPGQCKAPCIS 776
               E    V  L P T Y F VR   D    P+S V   +T     AGPP   K   I 
Sbjct: 773 LQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIE 832

Query: 777 CTPDGCVLVGWESPDSSGADISEYRLEWGEDE-----ESLELIYHGTDTRFEIRDLLPAA 831
              D   LV W+ PD     ++ Y + +   +     E   L   G  T   + +L+   
Sbjct: 833 ---DDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGN 889

Query: 832 QYCCRLQAFNQAGAGPYSELV 852
            Y  ++ A N+ G GP+S  V
Sbjct: 890 VYIVKISASNEVGEGPFSNSV 910



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 118/536 (22%), Positives = 207/536 (38%), Gaps = 56/536 (10%)

Query: 546  FRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
            ++  A N++G       L    S DRP  P     +  ++S    + W+ P  N   +++
Sbjct: 393  YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAE-TMSSSAILLAWERPLYNS-DKVI 450

Query: 606  KYLLEITDGNSEANQ-WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPV 664
             Y +         N+ ++V      T Y    L+P + Y          G SQ S+ +  
Sbjct: 451  AYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQ 510

Query: 665  RTLSIAPGQCRPPRV-LGRPKHKEVHLEW-DVPASESGCEVSEYSVEMTEPEDVASEVYH 722
             TL   P   RPP + L      ++ + W  +PA     +V  Y +      + + +V  
Sbjct: 511  NTLEDVP--LRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLE 568

Query: 723  --GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSD-VSEITTAAGPPGQCKAPCISCTP 779
              G   E  +  L P +VY  R+ A    G G  S   S  T  A      K+P +   P
Sbjct: 569  LPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEP 628

Query: 780  DGC--VLVGWESPDSSGADISEYRLEWGED--EESLELIYHGTDTRFEIRDLLPAAQYCC 835
              C  + V W+      A I  Y+L + E+  +E+  +     D  + +  L P  +Y  
Sbjct: 629  LNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHV 688

Query: 836  RLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSP---------SACL 886
            RL A+N    G  ++  +  TP          CV   + +   P  P         S+ +
Sbjct: 689  RLLAYNNIDDGYQADQTV-STPG---------CVSVRDRMVPPPPPPHHLYAKANTSSSI 738

Query: 887  VLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHV--------MKDLLPETTYRIRIQAI 938
             L+W  P    ++I+ YTI      +   +  +++        ++ L P T Y   ++  
Sbjct: 739  FLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLH 798

Query: 939  NEIGAGPFSQFIKAKTRPLPPLPPRL--ECAAAGPQSLKLKWGDSNSKTHAAEDIV--YT 994
             +  + P+S  +   T P  P  P +  +       +  + W   +      E +V  YT
Sbjct: 799  VDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGP----ETVVTRYT 854

Query: 995  LQLEDRNKRFIS-----IYRGPSHTYKV-QRLTEFTCYSFRIQAASEAGEGPFSET 1044
            +    R K +I+     ++R  + T  + + L     Y  +I A++E GEGPFS +
Sbjct: 855  ILYASR-KAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNS 909



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 71/312 (22%), Positives = 127/312 (40%), Gaps = 30/312 (9%)

Query: 866  TLCVLEEEPLDAY----PDSPSACLVLNWEEPCNNGSEILAYTIDL--------GDTSIT 913
            T+ + E+ P   Y        S+ ++L WE P  N  +++AY++           +  + 
Sbjct: 411  TVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVV 470

Query: 914  VGNTTMH-VMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT-RPLPPLPPRLECAAAGP 971
            +GN T H ++ DL P + Y   I A   +GA   S  +   T   +P  PP +   +  P
Sbjct: 471  IGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSP 530

Query: 972  QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR--GPSHTYKVQRLTEFTCYSFR 1029
              + + W    +K    + ++Y L      +  I +    G +H Y ++ L   + Y  R
Sbjct: 531  TDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVR 590

Query: 1030 IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQ--LEGNSC---EILW----ETVPSM 1080
            I AA+  G G  S   +  T K+   ++KAP+  +  LE  +C    + W    E   ++
Sbjct: 591  ITAATRVGLGESSVWTSHRTPKAT--SVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAI 648

Query: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSG 1140
            +G  + Y  +   G++         ++  + +SGL     Y  R+ A     D  Q    
Sbjct: 649  QGYKLYYKEE---GQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQT 705

Query: 1141 AFSPSAAFVLQR 1152
              +P    V  R
Sbjct: 706  VSTPGCVSVRDR 717



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 120/528 (22%), Positives = 194/528 (36%), Gaps = 79/528 (14%)

Query: 478 PSAPRLVRA---GITWVTLQWSKPEGCSPEEVITYTLEIQEDEN-DNLFHPKYTGEDLT- 532
           PSAP  V A     + + L W +P   S ++VI Y++   + E  +N  +    G D T 
Sbjct: 419 PSAPYNVHAETMSSSAILLAWERPLYNS-DKVIAYSVHYMKAEGLNNEEYQVVIGNDTTH 477

Query: 533 CTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRP-GPPTRPLVKGPVTSHGFSV 591
             + +L+ ++ Y F + A    G S  S+ +   T  D P  PP   L     T     +
Sbjct: 478 YIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTD--ILI 535

Query: 592 KWDP-PKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 650
            W P P      +++ Y L        + Q  +   G+  EY    LKP ++Y +R    
Sbjct: 536 SWLPIPAKYRRGQVVLYRLSFRLSTENSIQ-VLELPGTTHEYLLEGLKPDSVYLVRITAA 594

Query: 651 STGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLE----------WDVPASESG 700
           +  G  + S     RT      +         PK  E+HLE          W     ++ 
Sbjct: 595 TRVGLGESSVWTSHRTPKATSVKA--------PKSPELHLEPLNCTTISVRWQQDVEDTA 646

Query: 701 CEVSEYSVEMTEPEDVASEVYHGP------ELECTVGNLLPGTVYRFRVRALN--DGGYG 752
             +  Y +   E      +  +GP      +L  T+  L P   Y  R+ A N  D GY 
Sbjct: 647 A-IQGYKLYYKEE----GQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQ 701

Query: 753 PYSDVS---------EITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE 803
               VS          +     PP    A          + + W  P  + A I  Y + 
Sbjct: 702 ADQTVSTPGCVSVRDRMVPPPPPPHHLYA---KANTSSSIFLHWRRPAFTAAQIINYTIR 758

Query: 804 W---GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASA 860
               G    SL L    ++T   ++ L P  +Y   ++      + P+S +V   T   A
Sbjct: 759 CNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEA 818

Query: 861 P--DPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV---- 914
           P   PV     L E+             +++W+ P    + +  YTI        +    
Sbjct: 819 PAGPPVGVKVTLIEDDT----------ALVSWKPPDGPETVVTRYTILYASRKAWIAGEW 868

Query: 915 ------GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRP 956
                 G  TM ++++L+    Y ++I A NE+G GPFS  ++    P
Sbjct: 869 QVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLP 916



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 121/535 (22%), Positives = 195/535 (36%), Gaps = 53/535 (9%)

Query: 257 SNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSY 316
           S  S L    L V   +D  S         + + A++L+W  P+      +S     YS 
Sbjct: 400 SQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLY-----NSDKVIAYSV 454

Query: 317 EVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHS 376
               ++   + +Y+++   +     + DL PA++Y   + A         S+ V+  T  
Sbjct: 455 HYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLE 514

Query: 377 CAPECPFPPKLAHRSKSSLTLQWKAPID---NGSKITNYLLEWDEGKRNSGFRQCFFGSQ 433
             P  P    L  RS + + + W  PI       ++  Y L +     NS       G+ 
Sbjct: 515 DVPLRPPEISLTSRSPTDILISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTT 573

Query: 434 KHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPS--APR-----LVRA 486
               L  L P   Y  R+ A   +G      E   +T    P+  S  AP+     L   
Sbjct: 574 HEYLLEGLKPDSVYLVRITAATRVGLG----ESSVWTSHRTPKATSVKAPKSPELHLEPL 629

Query: 487 GITWVTLQWSK--PEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQY 544
             T ++++W +   +  + +    Y  E  + EN  +F      +DL  T+  L    +Y
Sbjct: 630 NCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIF---LDTKDLLYTLSGLDPRRKY 686

Query: 545 KFRLTASNTEGKSCPSEVLV----CTTSPDR---PGPPTRPLVKGPVTSHGFSVKWDPPK 597
             RL A N       ++  V    C +  DR   P PP   L     TS    + W  P 
Sbjct: 687 HVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPA 746

Query: 598 DNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQ 657
               ++I+ Y +       +     +    S T      L+P T Y+           S 
Sbjct: 747 FT-AAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSP 805

Query: 658 CSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASES-----GCE--VSEYSVEM 710
            S  +   TL  AP         G P   +V L  D  A  S     G E  V+ Y++  
Sbjct: 806 WSPVVYHSTLPEAPA--------GPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILY 857

Query: 711 TEPED-VASE--VYH--GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEI 760
              +  +A E  V H  G      + NL+ G VY  ++ A N+ G GP+S+  E+
Sbjct: 858 ASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVEL 912



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 76/371 (20%), Positives = 136/371 (36%), Gaps = 38/371 (10%)

Query: 783  VLVGWESPDSSGADISEYRLEW----GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQ 838
            +L+ WE P  +   +  Y + +    G + E  +++     T + I DL PA+ Y   + 
Sbjct: 435  ILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIV 494

Query: 839  AFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEE-PCN-N 896
            A+   GA   S+ V   T    P     + +    P D         ++++W   P    
Sbjct: 495  AYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTD---------ILISWLPIPAKYR 545

Query: 897  GSEILAYTIDLG---DTSITV----GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
              +++ Y +      + SI V    G T  ++++ L P++ Y +RI A   +G G  S +
Sbjct: 546  RGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVW 605

Query: 950  IKAKTRPLP----PLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFI 1005
               +T        P  P L        ++ ++W      T A +      + E + +   
Sbjct: 606  TSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGP 665

Query: 1006 SIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTT-------KSVPPTIK 1058
                     Y +  L     Y  R+ A +   +G +    T ST        + VPP   
Sbjct: 666  IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDG-YQADQTVSTPGCVSVRDRMVPPPPP 724

Query: 1059 APRVTQLEGNSCEIL--WETVPSMKGDPVNYILQVL-VGRESEYKQVY-KGEEATFQISG 1114
               +      S  I   W          +NY ++   VG ++    +Y +  E    + G
Sbjct: 725  PHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQG 784

Query: 1115 LQTNTDYRFRV 1125
            L+ NT Y F V
Sbjct: 785  LEPNTKYEFAV 795


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,656,436
Number of Sequences: 37866
Number of extensions: 3024867
Number of successful extensions: 21570
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 13567
Number of HSP's gapped (non-prelim): 3172
length of query: 1204
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1090
effective length of database: 13,930,794
effective search space: 15184565460
effective search space used: 15184565460
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.