Guide to the Human Genome
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Search of human proteins with 205277423

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205277423 immunoglobulin superfamily, member 9 isoform b
[Homo sapiens]
         (1163 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom...  2379   0.0  
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom...  2365   0.0  
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]     733   0.0  
gi|118572606 hemicentin 1 [Homo sapiens]                              135   2e-31
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   134   5e-31
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   134   5e-31
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           130   9e-30
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   125   3e-28
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   125   3e-28
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   125   3e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        124   5e-28
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   122   2e-27
gi|222352127 sidekick 2 [Homo sapiens]                                120   1e-26
gi|157311649 neogenin homolog 1 [Homo sapiens]                        120   1e-26
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   117   5e-26
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   117   5e-26
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   117   5e-26
gi|109150416 peroxidasin [Homo sapiens]                               117   5e-26
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   115   2e-25
gi|83281200 protogenin [Homo sapiens]                                 115   2e-25
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   115   2e-25
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...   113   1e-24
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   111   5e-24
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     110   6e-24
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      110   6e-24
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   110   6e-24
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   110   8e-24
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    108   3e-23
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    108   3e-23
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   108   3e-23

>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
            sapiens]
          Length = 1163

 Score = 2379 bits (6166), Expect = 0.0
 Identities = 1163/1163 (100%), Positives = 1163/1163 (100%)

Query: 1    MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
            MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1    MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60

Query: 61   GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
            GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61   GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120

Query: 121  DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
            DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121  DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180

Query: 181  QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
            QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181  QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240

Query: 241  SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
            SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241  SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300

Query: 301  CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360
            CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT
Sbjct: 301  CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360

Query: 361  EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
            EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL
Sbjct: 361  EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420

Query: 421  LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480
            LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA
Sbjct: 421  LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480

Query: 481  TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540
            TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD
Sbjct: 481  TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540

Query: 541  WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600
            WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP
Sbjct: 541  WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600

Query: 601  PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660
            PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG
Sbjct: 601  PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660

Query: 661  TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720
            TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL
Sbjct: 661  TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720

Query: 721  AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780
            AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG
Sbjct: 721  AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780

Query: 781  SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840
            SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG
Sbjct: 781  SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840

Query: 841  PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900
            PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP
Sbjct: 841  PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900

Query: 901  LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960
            LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS
Sbjct: 901  LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960

Query: 961  PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020
            PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP
Sbjct: 961  PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020

Query: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080
            PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM
Sbjct: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080

Query: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140
            ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR
Sbjct: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140

Query: 1141 DATRARLPAYRQPVPHPEQATLL 1163
            DATRARLPAYRQPVPHPEQATLL
Sbjct: 1141 DATRARLPAYRQPVPHPEQATLL 1163


>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
            sapiens]
          Length = 1179

 Score = 2365 bits (6128), Expect = 0.0
 Identities = 1162/1179 (98%), Positives = 1162/1179 (98%), Gaps = 16/1179 (1%)

Query: 1    MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
            MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1    MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60

Query: 61   GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
            GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61   GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120

Query: 121  DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
            DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121  DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180

Query: 181  QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
            QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181  QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240

Query: 241  SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
            SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241  SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300

Query: 301  CVPSNGLLHPPSASAYLTVLC----------------MPGVIRCPVRANPPLLFVSWTKD 344
            CVPSNGLLHPPSASAYLTVL                 MPGVIRCPVRANPPLLFVSWTKD
Sbjct: 301  CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360

Query: 345  GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 404
            GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF
Sbjct: 361  GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420

Query: 405  IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 464
            IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA
Sbjct: 421  IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480

Query: 465  HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 524
            HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS
Sbjct: 481  HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540

Query: 525  VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584
            VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL
Sbjct: 541  VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600

Query: 585  SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 644
            SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG
Sbjct: 601  SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660

Query: 645  RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 704
            RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV
Sbjct: 661  RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720

Query: 705  YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 764
            YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI
Sbjct: 721  YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780

Query: 765  FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 824
            FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL
Sbjct: 781  FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840

Query: 825  PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 884
            PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI
Sbjct: 841  PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900

Query: 885  EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 944
            EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR
Sbjct: 901  EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960

Query: 945  CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1004
            CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS
Sbjct: 961  CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020

Query: 1005 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1064
            LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT
Sbjct: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080

Query: 1065 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1124
            SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA
Sbjct: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140

Query: 1125 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1163
            RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Sbjct: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179


>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
          Length = 1349

 Score =  733 bits (1891), Expect = 0.0
 Identities = 437/1026 (42%), Positives = 568/1026 (55%), Gaps = 85/1026 (8%)

Query: 1    MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55
            M+W +   + S++ ++G    G    + E   V  RAGESVVL CD++ P  G+PP +V+
Sbjct: 1    MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60

Query: 56   EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115
            EW +FG  +PIFI+FG Y P +DP+Y GR  L   ASL++E +R EDQGWYEC+V  LDQ
Sbjct: 61   EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120

Query: 116  HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175
                D F NGSWVHLT+N+PP F ETPP  +E +E   +T+ C A G+P P VTW   G 
Sbjct: 121  QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178

Query: 176  DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235
             LG   G+ QV +G+L +  V R   G YTC+A S +G A H T LLV GPP IV PP+N
Sbjct: 179  LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237

Query: 236  STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295
             TVN SQD  L C AEAYP NLTY+W+  + NV+  + L+ RVRIL+DG+L +   +P+D
Sbjct: 238  ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297

Query: 296  AGCYTCVPSNGLLHPPSASAYLTV------LCMP----------GVIRCPVRANPPLLFV 339
            +G YTCVPSN L   PSASAYLTV      L MP          G IRCPV A PP   V
Sbjct: 298  SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357

Query: 340  SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
             W KDG+ LQ++K  GW+   +GS+ I    E+ALG Y+C PYN+LGT G S   R++LK
Sbjct: 358  KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417

Query: 400  APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 459
             PP F   P  EY QE GRELLIPC+A GDP PV++W KVG+  + +     + SL  R 
Sbjct: 418  DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477

Query: 460  LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 519
            L+KE HG WEC A+N V  +  ST++ V+GTSPH   +V V      ANVSWEPG+DGGY
Sbjct: 478  LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537

Query: 520  LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 579
             Q FSVW     KR     HDW+SL VP G + LLV  L+P T YQFSVLAQNKLG+  F
Sbjct: 538  EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593

Query: 580  SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 639
            SE+V       P T   P +  T       PPR L+A RT +GVLL W PP      +D 
Sbjct: 594  SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646

Query: 640  YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 699
            Y++E R  ++ WE+LD  + GTE E     L +D  YEFR++A     +S+PSN A VS+
Sbjct: 647  YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705

Query: 700  SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 759
            +  +++P        L +PVLAG+V  +CFL  A+L S LA C +N++R  + +RK+   
Sbjct: 706  T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760

Query: 760  DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 799
            DPPL  +   KS  +P + G  SP+S+  L+        QG P              SL 
Sbjct: 761  DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820

Query: 800  QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 859
            +       +   S       +    P+E I RGPDGRFVM P    P  +S R +  P  
Sbjct: 821  KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880

Query: 860  PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 904
                +   F  S         P  +      ++P++       PPPA      P  L GP
Sbjct: 881  EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940

Query: 905  GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 955
            G L   L        P  R  +    +  L   SP     PP Y+     P SS + SP 
Sbjct: 941  GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000

Query: 956  TPPVSP 961
             P   P
Sbjct: 1001 LPTEGP 1006



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%)

Query: 777  LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 828
            L S SP  V         V S   S++   P  T  P  HP  P   G       LPL  
Sbjct: 970  LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029

Query: 829  ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 876
               G     P GR  F  G    P +  P +    +  E   P   L R    +S   P+
Sbjct: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089

Query: 877  GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930
              P  L +E        SP   P  APP+      P+   +S    R  +     P L  
Sbjct: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149

Query: 931  PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 977
            P PA P  +       +DTR      +      P  SPR+      SL   V+     + 
Sbjct: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203

Query: 978  PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1026
               + L+  T       R R  PGLL  A    +T Q     S  R S      PS +  
Sbjct: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263

Query: 1027 AGGSYLSPAPGDTS 1040
            +G     PA G T+
Sbjct: 1264 SGSPSYRPAMGFTT 1277



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%)

Query: 599  LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 650
            LPP ++P  L P  GL     PRG+     PP    VP    G + LE  +G  G     
Sbjct: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110

Query: 651  WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 706
              V  P  A  +   + P    G ++       +        ++P      ST GL+   
Sbjct: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167

Query: 707  SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 762
            +R   P   P+P           L   VL    +S L    L+ R  +     R R  P 
Sbjct: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227

Query: 763  LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 814
            L+     + A  S +    P +V+  +       S  QS   G P+  P        + +
Sbjct: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282

Query: 815  PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 874
            P PP   GP P  P     D   V G T +    R+G E   P TP   L  S       
Sbjct: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334

Query: 875  PSGAPQP 881
            P+ A  P
Sbjct: 1335 PAPATSP 1341


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  135 bits (341), Expect = 2e-31
 Identities = 135/509 (26%), Positives = 214/509 (42%), Gaps = 61/509 (11%)

Query: 20   GRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDP 79
            G  +P  ++V+     ++    D +PP       VI WLR G  L         +PR+  
Sbjct: 3624 GTDEPRDITVLRNRQVTLECKSDAVPPP------VITWLRNGERLQA-------TPRV-- 3668

Query: 80   DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ 139
                R+ L  G  LQI    + D   Y C    +      +         LTVN PP  +
Sbjct: 3669 ----RI-LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-------LTVNVPPNIK 3716

Query: 140  ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVER 198
              P +++ +     V L C+A G P P +TW+  G  L     +  + +NG L I+    
Sbjct: 3717 GGPQSLVILLNKSTV-LECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHV 3775

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258
              +G Y C A++  G+      L V  PP I   P N TV  +   +LAC A   P   +
Sbjct: 3776 TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP-KPS 3834

Query: 259  YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------L 307
             +W + N ++ ++ + Q   R+L  GSL +++   DD   Y C  +NG           +
Sbjct: 3835 INW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV 3893

Query: 308  LHPPS----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS 363
              PPS     + +L     P VI C   +  P   + WTK+G  L L +  G+   + G+
Sbjct: 3894 QVPPSIADEPTDFLVTKHAPAVITC-TASGVPFPSIHWTKNGIRL-LPRGDGYRILSSGA 3951

Query: 364  LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
            + I     +  G Y+C   N+ G+A       V    PP    +P E +   +   +L+P
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHV--HEPPVIQPQPSELHV-ILNNPILLP 4008

Query: 424  CSAQGDPPPVVSWTKVGRGL----QGQAQVDSNSSLILRPLTKEAHGHWECSASN----A 475
            C A G P P ++W K G  +    +  A + S    I R + ++A G + C A N    A
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDA-GTYMCVAQNPAGTA 4067

Query: 476  VARVATSTNVYVLGTSPHVVTNVSVVALP 504
            + ++  +  V  +  SPH+   V  V  P
Sbjct: 4068 LGKIKLNVQVPPV-ISPHLKEYVIAVDKP 4095



 Score =  127 bits (319), Expect = 6e-29
 Identities = 107/378 (28%), Positives = 168/378 (44%), Gaps = 30/378 (7%)

Query: 128  VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQV 186
            V L V+ PP  Q  P + L V    P+ L C A G+P P +TW+  G ++   G+    +
Sbjct: 3980 VTLHVHEPPVIQPQP-SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038

Query: 187  QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
             +G L+I R  R  +G Y C A +  G+A    +L V  PPVI    K   +   + ++L
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITL 4098

Query: 247  ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
            +C A+  P     +W +D   +        R R+L  GSL++   QP DAG YTC+ +N 
Sbjct: 4099 SCEADGLPPP-DITWHKDGRAIVE----SIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN- 4152

Query: 307  LLHPPSASAYLTVLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQL 350
            +    S S  LTV   P                 ++ C V    P   ++W KD   L  
Sbjct: 4153 VAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWKKD-NVLLA 4210

Query: 351  DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410
            +    ++    G LI+     +  G Y+C   N+ G    +    + +   P F E P +
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE--DTHTVSLTVHVLPTFTELPGD 4268

Query: 411  EYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ-AQVDSNSSLILRPLTKEAHGHWE 469
                + G +L + C A G P P ++WT     +      V+ +S L++  ++KE  G + 
Sbjct: 4269 VSLNK-GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYV 4327

Query: 470  CSASNAVARVATSTNVYV 487
            C+A N+V  V     VYV
Sbjct: 4328 CTAENSVGFVKAIGFVYV 4345



 Score =  124 bits (311), Expect = 5e-28
 Identities = 100/363 (27%), Positives = 168/363 (46%), Gaps = 31/363 (8%)

Query: 152  EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211
            +P+TL C A G P P +TW   G+ + +   Q  + +G+L+I  V+ G +G YTC A++ 
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV 4153

Query: 212  EGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHI 271
             GS++ +T+L V  PP I     + TVN +    L C A+  P     +W +DN+    +
Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP-AINWKKDNV---LL 4209

Query: 272  SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL---LHPPSASAYL--TVLCMPG-- 324
            + L  +      G L L     +D+G YTCV +N      H  S + ++  T   +PG  
Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDV 4269

Query: 325  ------VIRCPVRANP-PLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALGNEDALG 375
                   +R   +A   PL  ++WT +   +    D   G S+     L+I   +++  G
Sbjct: 4270 SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE-----LVIERVSKEDSG 4324

Query: 376  EYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVS 435
             Y CT  NS+G      +  V +K PP F       + + +G   ++ C  +GDP P + 
Sbjct: 4325 TYVCTAENSVGFV--KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQ 4382

Query: 436  WTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPH 493
            W + G  ++   ++    N SL +     E  G + C A+N    V  S ++ +   SP 
Sbjct: 4383 WNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL--QSPP 4440

Query: 494  VVT 496
            ++T
Sbjct: 4441 IIT 4443



 Score =  123 bits (308), Expect = 1e-27
 Identities = 110/424 (25%), Positives = 173/424 (40%), Gaps = 41/424 (9%)

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
            R R+    SLQI  ++  D G Y C    +         ++ +   LTV+ PP+ + T  
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG-------SSSTSTKLTVHVPPRIRSTE- 4175

Query: 144  AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN-GTLRIRRVERGSSG 202
                V E     L CVA G P P + WK     L    G+   +  G L +  V    SG
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG 4235

Query: 203  VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
             YTC A++  G  TH   L V   P     P + ++N  + + L+C A   P       F
Sbjct: 4236 FYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF 4295

Query: 263  QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL-----------LHPP 311
             +NI   H   +     ++++          +D+G Y C   N +             PP
Sbjct: 4296 NNNIIPAHFDSVNGHSELVIE------RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349

Query: 312  S-----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
                   S ++  L    ++ C V+ +P    + W + G  +++       Q   GSL I
Sbjct: 4350 VFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISH--RIRQLGNGSLAI 4406

Query: 367  -ALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425
                NEDA G+Y+C   N  G    S    + L++PP     P E      G ++++ C 
Sbjct: 4407 YGTVNEDA-GDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVIN-AGGKIILNCQ 4462

Query: 426  AQGDPPPVVSWTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATST 483
            A G+P P ++W++ G  +    +V+  SN+SL +    KE    +EC A N +  V    
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522

Query: 484  NVYV 487
             V V
Sbjct: 4523 PVIV 4526



 Score =  110 bits (274), Expect = 1e-23
 Identities = 113/446 (25%), Positives = 180/446 (40%), Gaps = 47/446 (10%)

Query: 92  SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEVQE 150
           +L I  + + D+G+YEC        I       G +     V+ PP   + P  V  V  
Sbjct: 483 NLDIAKVTLSDEGFYEC--------IAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT-VTP 533

Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKD--LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
            E   L C+   +   ++TW+   +D  L +      + N +L ++ V+   +G Y C  
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593

Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV 268
           SS  GS+  +  L V  PP + V PKN +     +VS+ C A  YP     +W  +++ +
Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP-KPKIAWTVNDMFI 652

Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LLHPPS----A 313
                   R R+  DG+L +    P DAG Y C+ SN             +  P      
Sbjct: 653 VG----SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708

Query: 314 SAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA 373
           S  L  L    V+ C     PP   V W K    L+   F        G L I    +  
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQ-VKWFKGDLELRPSTFL-IIDPLLGLLKIQETQDLD 766

Query: 374 LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPV 433
            G+Y+C   N  G A       V   +PP FI+ P  +   E+G  + +PC  QG P P 
Sbjct: 767 AGDYTCVAINEAGRATGKITLDV--GSPPVFIQEP-ADVSMEIGSNVTLPCYVQGYPEPT 823

Query: 434 VSWTKVGR--------GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
           + W ++           +   +Q+ + +  IL  L     G + C A N   ++ + T V
Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILN-LWASDKGTYICEAENQFGKIQSETTV 882

Query: 486 YVLG-TSPHVVTNVSVVALPKGANVS 510
            V G  +P +  + SV  + +G  ++
Sbjct: 883 TVTGLVAPLIGISPSVANVIEGQQLT 908



 Score =  107 bits (266), Expect = 9e-23
 Identities = 110/432 (25%), Positives = 176/432 (40%), Gaps = 55/432 (12%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-----LTVNSPPQFQET 141
            L  G  L I   +V + G Y C              AN +  H     +TV+ PP  + +
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMA------------ANTAGDHKKEFEVTVHVPPTIKSS 1831

Query: 142  PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERG 199
              +   V + +PV L+C+A G P P +TW    + +   QG +++Q+    L+I +    
Sbjct: 1832 GLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE 1891

Query: 200  SSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPK--NSTVNASQDVSLACHAEAYPANL 257
             +G YTC A++  G      QL V  PP +    K  N TV  S  V L C A   P  +
Sbjct: 1892 DAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPV 1951

Query: 258  TYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGL--------- 307
              +W++DN     +      +  L  G  + + + Q  DAG Y CV  N           
Sbjct: 1952 -ITWYKDN----RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006

Query: 308  -LH-PPSASAYLTVLCMPGVIRCPVR-----ANPPLLFVSWTKDGKALQLDKFPGWSQGT 360
             +H  PS S    ++ +  V+  PVR        P   ++W KDG    +  F    Q  
Sbjct: 2007 QVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNGLQVL 2062

Query: 361  EGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 418
             G  I+AL +      G Y+C   N+ G        RV +   P  I   ++     + +
Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV---PPNIMGEEQNVSVLISQ 2119

Query: 419  ELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASNA 475
             + + C +   PPP ++W K G  L    G +  ++ S L +     +  G + C A+N 
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNV 2179

Query: 476  VARVATSTNVYV 487
              +   + NV +
Sbjct: 2180 AGKTEKNYNVNI 2191



 Score =  106 bits (264), Expect = 1e-22
 Identities = 132/499 (26%), Positives = 193/499 (38%), Gaps = 62/499 (12%)

Query: 25   EVVSVVG-RAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
            E +SVV  R G SV L C+    +   P  VI W + G ++       +           
Sbjct: 3064 ESLSVVNVREGTSVSLECE----SNAVPPPVITWYKNGRMITESTHVEI----------- 3108

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
               L  G  L I+   V D G Y CR      ++   D  N    HL V  PP  +    
Sbjct: 3109 ---LADGQMLHIKKAEVSDTGQYVCRAI----NVAGRDDKN---FHLNVYVPPSIEGPER 3158

Query: 144  AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNG--TLRIRRVERGS 200
             V+      PVTL C A G P P + W    K +      +V++ +G   L+I R +   
Sbjct: 3159 EVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218

Query: 201  SGVYTCQASSTEGSATHATQLLVLGPPVIVVP--PKNSTVNASQDVSLACHAEAYPANLT 258
            SG YTC AS+ EG A     L +  PP +     P + +V   ++V L C+A   P  L 
Sbjct: 3219 SGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL- 3277

Query: 259  YSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------G 306
              W +D   +   S    R+R+  +GS L +      D G YTCV +N            
Sbjct: 3278 IQWLKDGKPI--ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335

Query: 307  LLHPPS-------ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
            +   P+       A   +T++     I C     PP   ++W K+G  L L         
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQ-INWLKNGLPLPLSSHIRLLAA 3394

Query: 360  TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-IERPKEEYFQEVGR 418
             +   I+     D +  Y+C   N  G        +V   APP        EE     G 
Sbjct: 3395 GQVIRIVRAQVSD-VAVYTCVASNRAGVDNKHYNLQVF--APPNMDNSMGTEEITVLKGS 3451

Query: 419  ELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-SNSSLILRPLTKEAH--GHWECSASNA 475
               + C   G P P ++W + G+ L   A +  S   ++L+ L  E    G + C ASN 
Sbjct: 3452 STSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511

Query: 476  VARVATSTNVYVLGTSPHV 494
               V+    + VL   PH+
Sbjct: 3512 AGEVSKHFILKVL-EPPHI 3529



 Score =  105 bits (261), Expect = 3e-22
 Identities = 135/510 (26%), Positives = 206/510 (40%), Gaps = 81/510 (15%)

Query: 24   PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
            PE +SVV +   SV L C+    A   PL  I W + G+  P+ +     S RI      
Sbjct: 2393 PENISVVEK--NSVSLTCE----ASGIPLPSITWFKDGW--PVSLS---NSVRI------ 2435

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ-ETP 142
               L  G  L++    +ED G Y C V        E+    G    L+V  PP    E  
Sbjct: 2436 ---LSGGRMLRLMQTTMEDAGQYTCVV---RNAAGEERKIFG----LSVLVPPHIVGENT 2485

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSS 201
               ++V+E + VTL C   G+P+P +TW   G+ L + +    +  G  L+I  V+   +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545

Query: 202  GVYTCQASSTEGSATHATQLLVLGPPVIV-----VPPKNSTVNASQDVSLACHAEAYPAN 256
            G YTC ASS  G  + +  L V   P I        P++ TV  +   SL C A +YP  
Sbjct: 2546 GRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP- 2604

Query: 257  LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSN---GLLHPPS 312
             T +WF+D   +         +RIL  G +L++L  Q D+AG Y+CV +N    ++    
Sbjct: 2605 ATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660

Query: 313  ASAYLTVLCMPGVIRCP--------VRANP-----------PLLFVSWTKDGKALQLDKF 353
               Y+  +   G +  P        ++ N            P   +SW KDG+ L+ D  
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720

Query: 354  PGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEY 412
               +     +L I        G Y+C   N    AG   +   V ++ PP+F +  +   
Sbjct: 2721 VNIAANGH-TLQIKEAQISDTGRYTCVASN---IAGEDELDFDVNIQVPPSFQKLWEIGN 2776

Query: 413  FQEVGRE-----------LLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILR 458
              + GR            + + C     PPP ++W K G  L    +V        L + 
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIP 2836

Query: 459  PLTKEAHGHWECSASNAVARVATSTNVYVL 488
                E  G + C A N     +   +V VL
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866



 Score =  104 bits (260), Expect = 4e-22
 Identities = 113/414 (27%), Positives = 164/414 (39%), Gaps = 42/414 (10%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
            L +G  + IE  ++ D G Y+C              A   +  L V+  P    +   V 
Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAI-------NSAGATELFYSLQVHVAPSISGSNNMVA 2022

Query: 147  EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVY 204
             V    PV L C ARG P P +TW   G  +      +QV +G   L +   +   +G Y
Sbjct: 2023 VVVN-NPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
            TC A +  G       L V  PP I+   +N +V  SQ V L C ++A P   T +W +D
Sbjct: 2082 TCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP-TLTWLKD 2140

Query: 265  NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
                 H    +P + I  + S L++   Q  D G YTC  +N            +  PP+
Sbjct: 2141 G----HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN 2196

Query: 313  --ASAYLTVLCMPG----VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---WSQGTEGS 363
               S  LT L +       + C     PP   + W K G  +  D        S G +  
Sbjct: 2197 IGGSDELTQLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQ 2255

Query: 364  LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
            + IA  ++ AL  YSC   N  GTA      +V ++           E     G+ + + 
Sbjct: 2256 ISIAEKSDAAL--YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE 2313

Query: 424  CSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474
            C  QG PPP V+W K G  L   +G   +D    L L+ +     G + C A N
Sbjct: 2314 CEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN 2367



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 124/497 (24%), Positives = 193/497 (38%), Gaps = 63/497 (12%)

Query: 22   GKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDY 81
            G  E+  +    G  + L C+    +G PP ++I W + G            SP +  D 
Sbjct: 2199 GSDELTQLTVIEGNLISLLCE---SSGIPPPNLI-WKKKG------------SPVLT-DS 2241

Query: 82   VGRVR-LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQE 140
            +GRVR L  G  LQI      D   Y C V        + ++    ++  T+ +      
Sbjct: 2242 MGRVRILSGGRQLQISIAEKSDAALYSC-VASNVAGTAKKEYNLQVYIRPTITN----SG 2296

Query: 141  TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERG 199
            + P  + V   + ++L C  +G P P VTW   G  L + +G   +  G  L+++ +   
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356

Query: 200  SSGVYTCQASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPAN 256
             +G Y C A +  G       L V  PP I+     P+N +V     VSL C A   P  
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416

Query: 257  LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             + +WF+D   V     L   VRIL  G  LRL+ T  +DAG YTCV  N          
Sbjct: 2417 -SITWFKDGWPV----SLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471

Query: 316  YLTVLCMPGVI------------------RCPVRANPPLLFVSWTKDGKALQLDKFPGWS 357
             L+VL  P ++                   C V  N P+  ++W KDG+ LQ D+     
Sbjct: 2472 -LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHKDGQPLQEDEA---H 2526

Query: 358  QGTEGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI--ERPKEEYF 413
                G   + + N      G Y+C   +  G    S    V +    A +  +   E+  
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586

Query: 414  QEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWEC 470
              +     + C A   PP  ++W K G  L+    +       +L +    ++  G + C
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646

Query: 471  SASNAVARVATSTNVYV 487
             A+N    +     V V
Sbjct: 2647 VATNEAGEMIKHYEVKV 2663



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 105/416 (25%), Positives = 165/416 (39%), Gaps = 55/416 (13%)

Query: 128  VHLTVNSPPQ-------FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQ- 179
            V LTV   P+         +  P  + V   E VTL C  +  P P +TW    + +   
Sbjct: 1064 VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPF 1123

Query: 180  GQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN 239
                  + +G+++I       SG+Y C A++  G+ T A +L V  PP I   PK+  V 
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ 1183

Query: 240  ASQDVSLACHAEAYPANLTYSWFQDNINVF-----HISRLQPRVRILVDGSLRLLATQPD 294
              Q V + C+A+  P  +  +W +    +      H+S          DG+L +    P 
Sbjct: 1184 VGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVSN--------PDGTLSIDQATPS 1234

Query: 295  DAGCYTCVPSNGL-------------------LHPPSASAYLTVLCMPGV-IRCPVRANP 334
            DAG YTCV +N                     L PP  + +   +    +   CP +  P
Sbjct: 1235 DAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP 1294

Query: 335  PLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPV 393
                + W  +G+ L   + PG S   +G+ L+IA       GEY C   N  GT      
Sbjct: 1295 KPT-IKWLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYN 1352

Query: 394  TRVLLKAPPAFIERPKEEYFQEVGRELL-IPCSAQGDPPPVVSWTKVGRGLQGQAQVDS- 451
             +V    PP   ++ +      +  +L  + C  +G P P++ W K    +   + + + 
Sbjct: 1353 LKV--HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410

Query: 452  NSSLILR--PLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN----VSVV 501
            N+  IL+    T E  G + C A N         N+ VL     + TN    VSVV
Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVV 1466



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 100/375 (26%), Positives = 155/375 (41%), Gaps = 35/375 (9%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP---AVL 146
            G +LQI   +V D G Y C +        +  F+      LTV  PP  ++      +V+
Sbjct: 3017 GRTLQIIRAKVSDGGEYTC-IAINQAGESKKKFS------LTVYVPPSIKDHDSESLSVV 3069

Query: 147  EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSGVYT 205
             V+E   V+L C +   P P +TW   G+ + +    ++      L I++ E   +G Y 
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYV 3129

Query: 206  CQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA-SQDVSLACHAEAYPANLTYSWFQD 264
            C+A +  G       L V  PP I  P +   V   S  V+L C A   P   T +W ++
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPP-TIAWLKN 3188

Query: 265  NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
            +  + +   L+  VRIL  GS L++  +Q  D+G YTC+ SN            +  PPS
Sbjct: 3189 HKRIENSDSLE--VRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPS 3246

Query: 313  AS-----AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
             +     + ++VL    V + C     P  L + W KDGK +   +         GS + 
Sbjct: 3247 VAGAEIPSDVSVLLGENVELVCNANGIPTPL-IQWLKDGKPIASGETERIRVSANGSTLN 3305

Query: 367  ALGN-EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425
              G      G+Y+C   N  G         V +       +   E+    V   + I C 
Sbjct: 3306 IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECR 3365

Query: 426  AQGDPPPVVSWTKVG 440
            A G PPP ++W K G
Sbjct: 3366 ATGTPPPQINWLKNG 3380



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 116/415 (27%), Positives = 167/415 (40%), Gaps = 52/415 (12%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS-WVHLTVNSPPQFQETPP-AVLE 147
            G  LQ+     ED G Y C        I  ++    S    L V  PP    +     + 
Sbjct: 3488 GMVLQLLKAETEDSGKYTC--------IASNEAGEVSKHFILKVLEPPHINGSEEHEEIS 3539

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVYT 205
            V    P+ L C+A G P P +TW   G+ L Q   QVQ   G   LRI   +   +G YT
Sbjct: 3540 VIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRISTAQVEDTGRYT 3598

Query: 206  CQASSTEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
            C ASS  G       + V  PP I     P++ TV  ++ V+L C ++A P  +  +W +
Sbjct: 3599 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLR 3657

Query: 264  DNINVFHISRLQ--PRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320
            +        RLQ  PRVRIL  G  L++      D   YTCV SN +    +    LTV 
Sbjct: 3658 NG------ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTREFILTVN 3710

Query: 321  CMPG----------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
              P                 V+ C +    P   ++W KDG A+       +S    G L
Sbjct: 3711 VPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITWRKDG-AVLAGNHARYSILENGFL 3768

Query: 365  IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
             I   +    G Y C   N+ GT       +V    PP+    P       V  +  + C
Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV--HVPPSIAPGP-TNMTVIVNVQTTLAC 3825

Query: 425  SAQGDPPPVVSWTKVGRGL-----QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474
             A G P P ++W K G  L     Q   ++ S+ SL++   + +    +EC+ +N
Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 121/503 (24%), Positives = 192/503 (38%), Gaps = 61/503 (12%)

Query: 27   VSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID-------- 78
            ++  GRA   + L     P   + P  V   +     LP ++Q G   P I         
Sbjct: 775  INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEPTIKWRRLDNMP 833

Query: 79   ----PDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFAN-GSWVHLTVN 133
                P  V  +   +  +L I  L   D+G Y C          E+ F    S   +TV 
Sbjct: 834  IFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA--------ENQFGKIQSETTVTVT 885

Query: 134  S-PPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTL 191
                      P+V  V E + +TL C +  G+P+P   W      L Q        +G+L
Sbjct: 886  GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSL 945

Query: 192  RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAE 251
             I RV+    G YTC AS+  G+    T ++V   P I    +  +      V+L C A 
Sbjct: 946  HIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKAS 1005

Query: 252  AYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPP 311
              P   +  W +       IS    +     DGSL +++   +++G Y C  +N   +  
Sbjct: 1006 GNP-KPSVIWSKKG---ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-A 1060

Query: 312  SASAYLTVLCMPGV------------------------IRCPVRANPPLLFVSWTKDGKA 347
                 LTV   P V                        + C V++ PP + ++W K+ + 
Sbjct: 1061 KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-ITWAKETQL 1119

Query: 348  LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
            +     P  +    GS+ I        G Y C   N  G    +   ++ +  PP     
Sbjct: 1120 IS-PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV--TQAVKLNVHVPPKIQRG 1176

Query: 408  PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDS-NSSLILRPLTKEA 464
            PK    Q VG+ + IPC+AQG P PV++W+K G  +   G+  V + + +L +   T   
Sbjct: 1177 PKHLKVQ-VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235

Query: 465  HGHWECSASNAVARVATSTNVYV 487
             G + C A+N      T   ++V
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHV 1258



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 109/439 (24%), Positives = 170/439 (38%), Gaps = 49/439 (11%)

Query: 84  RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
           R+R     SL+++ ++  D G Y C V         +  ++ + V LTV  PP+    P 
Sbjct: 567 RIRTLANLSLELKSVKFNDAGEYHCMV-------SSEGGSSAASVFLTVQEPPKVTVMPK 619

Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
                   E V++ C A G P P + W +    +          +GTL I+      +G+
Sbjct: 620 NQSFTGGSE-VSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGI 678

Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
           Y C AS++ G+    + L  +  P ++V      V       + C     P      WF+
Sbjct: 679 YGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP-QVKWFK 737

Query: 264 DNINVFHISRLQPRVRILVD---GSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV- 319
            ++       L+P   +++D   G L++  TQ  DAG YTCV  N       A+  +T+ 
Sbjct: 738 GDL------ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAIN---EAGRATGKITLD 788

Query: 320 -------LCMPGVIRCPVRANPPL-LFVSWTKDG--KALQLDKFP---------GWSQGT 360
                  +  P  +   + +N  L  +V    +   K  +LD  P           SQ  
Sbjct: 789 VGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLR 848

Query: 361 EGSLIIALGNEDALGEYSCTPYNSLG-TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
            G+L I        G Y C   N  G     + VT   L AP   I        +  G++
Sbjct: 849 TGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE--GQQ 906

Query: 420 LLIPCS-AQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
           L +PC+   G+P P   W K    L       V S+ SL +  +  +  G + C ASN  
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966

Query: 477 A--RVATSTNVYVLGTSPH 493
                 TS  V+VL T  H
Sbjct: 967 GTNNKTTSVVVHVLPTIQH 985



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 33/322 (10%)

Query: 82   VGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQET 141
            +G+   +    L +E + +ED G+Y C     +    ED       V LTV+  P F E 
Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTC---VANNAAGEDTHT----VSLTVHVLPTFTEL 4265

Query: 142  PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSS 201
            P  V  + + E + L C A G PLP +TW      +      V   +  L I RV +  S
Sbjct: 4266 PGDV-SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN-GHSELVIERVSKEDS 4323

Query: 202  GVYTCQASSTEGSATHATQLLVLGPPVIVVP-PKNSTVNASQDVSLACHAEAYPANLTYS 260
            G Y C A ++ G       + V  PPV     P N       +  L C  +  P   T  
Sbjct: 4324 GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP-TIQ 4382

Query: 261  WFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLH 309
            W +  +++     +  R+R L +GSL +  T  +DAG YTCV +N            L  
Sbjct: 4383 WNRKGVDI----EISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS 4438

Query: 310  PP--SASAYLTVLCMPG--VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
            PP  +     TV+   G  ++ C     P    ++W++ G ++  D     +  +  SL 
Sbjct: 4439 PPIITLEPVETVINAGGKIILNCQATGEPQPT-ITWSRQGHSISWD--DRVNVLSNNSLY 4495

Query: 366  IALGNEDALGEYSCTPYNSLGT 387
            IA   ++   E+ C   N +G+
Sbjct: 4496 IADAQKEDTSEFECVARNLMGS 4517



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 107/467 (22%), Positives = 166/467 (35%), Gaps = 70/467 (14%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP-PAV 145
            +  G  L++     ED G Y C+   +          +  + ++ V  PP    T  P  
Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAG-------TSQKYFNIDVLVPPTIIGTNFPNE 1462

Query: 146  LEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV--QNGTLRIRRVERGSSGV 203
            + V     V L C  +G+P P + W   GK L  G   V++  +   L ++   R   G 
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGR 1522

Query: 204  YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVS--------LACHAEAYPA 255
            Y C  S+  G      +L       I +PP     N + D+S        L C     P 
Sbjct: 1523 YQCTVSNAAGKQAKDIKL------TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPM 1576

Query: 256  NLTYSWFQDNINVFHISRLQPRVRILVDGS--LRLLATQPDDAGCYTCVPSN-------- 305
                +W++D   +   S+      + +D    L +   Q  D+  YTC  +N        
Sbjct: 1577 P-AITWYKDGQPIMSSSQ-----ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKS 1630

Query: 306  ---GLLHPPSASAYL-------TVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFP 354
                +  PP     L        V+     + C    NP P+L  +W KDG  ++ +   
Sbjct: 1631 FHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL--TWLKDGVPVKANDNI 1688

Query: 355  GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEYF 413
                G +  L I    E   G+Y C    +   AG   +   V +  PPA     +  YF
Sbjct: 1689 RIEAGGK-KLEIMSAQEIDRGQYICV---ATSVAGEKEIKYEVDVLVPPAIEGGDETSYF 1744

Query: 414  QEVGRELL-IPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWE 469
              +   LL + C   G PPP + W K G+ +    G   + +   L++        G + 
Sbjct: 1745 IVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYR 1804

Query: 470  CSASNAV--------ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508
            C A+N            V     +   G S  VV     VAL   AN
Sbjct: 1805 CMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 108/415 (26%), Positives = 166/415 (40%), Gaps = 51/415 (12%)

Query: 151 LEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQAS 209
           L+P  + C    S LP     +R G  LG  Q   +  +  L I +V     G Y C A 
Sbjct: 444 LQPGQIPCSV-DSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAV 502

Query: 210 STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC-HAEAYPANLTYSWFQDNINV 268
           S+ G+    T   V  PP ++  P N TV   +   L C    A   NLT+     ++ +
Sbjct: 503 SSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562

Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHPPSASAYLTVLCMPGVIR 327
                   R+R L + SL L + + +DAG Y C V S G     +AS +LTV   P V  
Sbjct: 563 AE----PARIRTLANLSLELKSVKFNDAGEYHCMVSSEG--GSSAASVFLTVQEPPKVTV 616

Query: 328 CPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372
            P                    P   ++WT +   + +     +   ++G+L I      
Sbjct: 617 MPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND--MFIVGSHRYRMTSDGTLFIKNAAPK 674

Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432
             G Y C   NS GT   +   R  ++AP   +   + E    +G   ++ C   G PPP
Sbjct: 675 DAGIYGCLASNSAGTDKQNSTLR-YIEAPKLMV--VQSELLVALGDITVMECKTSGIPPP 731

Query: 433 VVSWTKVGRGLQGQAQVDSNSSLILRPL--------TKEAH-GHWECSASNAVARVATST 483
            V W K      G  ++  ++ LI+ PL        T++   G + C A N   R AT  
Sbjct: 732 QVKWFK------GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGK 784

Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVW----YTPLAKRP 534
               +G+ P  +   + V++  G+NV+  P +  GY +    W      P+  RP
Sbjct: 785 ITLDVGSPPVFIQEPADVSMEIGSNVTL-PCYVQGYPEPTIKWRRLDNMPIFSRP 838



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 128/550 (23%), Positives = 204/550 (37%), Gaps = 98/550 (17%)

Query: 17   GADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPR 76
            G    G PE V+V+  +  S+V      PPA       I W + G  L       +    
Sbjct: 2575 GVGSDGNPEDVTVILNSPTSLVCEAYSYPPA------TITWFKDGTPLESNRNIRI---- 2624

Query: 77   IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS-- 134
                      L  G +LQI   + ++ G Y C            + A     H  V    
Sbjct: 2625 ----------LPGGRTLQILNAQEDNAGRYSCVA---------TNEAGEMIKHYEVKVYI 2665

Query: 135  PPQFQE-------TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
            PP   +         P  ++++    +TL C A   P   ++W   G+ L          
Sbjct: 2666 PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA 2725

Query: 188  NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPV---------IVVPPKNST 237
            NG TL+I+  +   +G YTC AS+  G       + +  PP          ++   +N  
Sbjct: 2726 NGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE 2785

Query: 238  ---VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQP 293
               V  +  +SL C   A P   T +W++D     H      +V IL  G  L++   + 
Sbjct: 2786 AKDVIINNPISLYCETNAAPPP-TLTWYKDG----HPLTSSDKVLILPGGRVLQIPRAKV 2840

Query: 294  DDAGCYTCVPSNG-----------LLHPPSASAY-------LTVLCMPGVIRCPVRANPP 335
            +DAG YTCV  N            +L PP            +TVL     +   + +  P
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSP 2900

Query: 336  LLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA-LGEYSCTPYNSLGTAGPSPVT 394
                SW KDG+ L  D    +   + G ++  L  +   +G Y C   N+ G+A      
Sbjct: 2901 APRNSWQKDGQPLLEDDHHKFL--SNGRILQILNTQITDIGRYVCVAENTAGSA--KKYF 2956

Query: 395  RVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454
             + +  PP+ I    E     V   + + C   G PPP +SW      L+ +  +  N++
Sbjct: 2957 NLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW------LKNEQPIKLNTN 3010

Query: 455  LILRPLTKEAH---------GHWECSASNAV--ARVATSTNVYV-LGTSPHVVTNVSVVA 502
             ++ P  +            G + C A N    ++   S  VYV      H   ++SVV 
Sbjct: 3011 TLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN 3070

Query: 503  LPKGANVSWE 512
            + +G +VS E
Sbjct: 3071 VREGTSVSLE 3080



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 33/215 (15%)

Query: 34   GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
            G + +L C++       P   I+W R G               +D +   R+R     SL
Sbjct: 4364 GGNAILNCEVKGD----PTPTIQWNRKG---------------VDIEISHRIRQLGNGSL 4404

Query: 94   QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
             I G   ED G Y C V   +  + E   +      LT+ SPP     P   + +     
Sbjct: 4405 AIYGTVNEDAGDYTC-VATNEAGVVERSMS------LTLQSPPIITLEPVETV-INAGGK 4456

Query: 154  VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
            + L C A G P P +TW  +G  +        + N +L I   ++  +  + C A +  G
Sbjct: 4457 IILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516

Query: 214  SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
            S      +LV  P ++ V    S  +A +  S+ C
Sbjct: 4517 S------VLVRVPVIVQVHGGFSQWSAWRACSVTC 4545


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  134 bits (337), Expect = 5e-31
 Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  L C   RG P P + WK     +   + ++ ++ G L I   
Sbjct: 151 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 209

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G+YTC  ++  G   +   +L V   P  +  P N  V   + V   C  +  P 
Sbjct: 210 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 269

Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
             T  W +D+ ++       PR R  I  D +LR+  T   D G Y C+  N +     A
Sbjct: 270 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 320

Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356
           SA LTV   P  V+R               C  + NP P +F  W K+G    L  FP  
Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 376

Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405
            Q           G L I        G Y C   T   S+       VT VL   PP  I
Sbjct: 377 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 436

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462
            +        V    L+ C A GDP PV+SW K G    G   +A +    +L ++ L  
Sbjct: 437 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496

Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509
              G + C A+++    + S  + V  +   +  N  +  LP                 +
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 556

Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569
           SW+PG  G       +    +      + + W ++A  V      V GL+P+T Y F V 
Sbjct: 557 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 612

Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619
           A N  G     P S+ V +       +P A G+   ++   L    G V VR       T
Sbjct: 613 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 664

Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674
           P  V + W   +  P+ + GY +      G Q +  W+ LD  V  TE   ++  L K V
Sbjct: 665 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 722

Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734
            YE ++  +   F    S +  V T+         + P   PQ V    VG      ++V
Sbjct: 723 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 774



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  V+ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 46  PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       G Y C A +  G A   +A+  + L        P +  V A +
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              L C         T  W +D +    I   + R+ I   G L +  T+  DAG YTCV
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 220

Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347
            +N +    S  A LTV   P  +R P+                   P   V W KD   
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 280

Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
           L   ++       + +L I        G Y C   N +G    S    V  +APP F+ R
Sbjct: 281 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 335

Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457
           P+++   + GR +  PC  +G+P P V W K G          +    +  V     L +
Sbjct: 336 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394

Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517
             + +   G++ C A      +     + V      +      + L   AN +     DG
Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 449

Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567
             L +      PL          W+            A       L +  L+      ++
Sbjct: 450 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503

Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627
            +A +  G   +S ++     G      +     +++P P S P+  V   T   V L W
Sbjct: 504 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 558

Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685
            P          Y++E   +  S  W+ +   V    T   V GL  + +Y F + A   
Sbjct: 559 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 616

Query: 686 SFVSDPS 692
             +SDPS
Sbjct: 617 QGLSDPS 623



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%)

Query: 29  VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
           VV  AGE  +L C   PP G P    I W +                RID D   R+ + 
Sbjct: 158 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 199

Query: 89  KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
           +G  L I   R  D G Y C    +      D         LTV   P F   P   + +
Sbjct: 200 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 253

Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
           +E E V  RC  +G P P V WK    DL +G+  ++  + TLRI++      G Y C A
Sbjct: 254 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 311

Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
            +  G    +  L V  PP  VV P++  V   + V+  C  +  P    +   + + N 
Sbjct: 312 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 371

Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
           +F     QP  R  V   G L +   Q  DAG Y C     +  +L       +  LT  
Sbjct: 372 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431

Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
             P +++ P                    PL  +SW K+G      + P  +   +G+L 
Sbjct: 432 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 490

Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
           I        G Y+C   +S G    S V  V
Sbjct: 491 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 521



 Score = 37.4 bits (85), Expect = 0.084
 Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%)

Query: 23  KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80
           +P  + + G A +++ + G  LL   A   PL VI WL+ GF  P            DP 
Sbjct: 431 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 479

Query: 81  YVGRVRLQKGASLQIEGLRVEDQGWYEC 108
              R  +Q+  +LQI+ LR+ D G Y C
Sbjct: 480 ---RATIQEQGTLQIKNLRISDTGTYTC 504


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  134 bits (337), Expect = 5e-31
 Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  L C   RG P P + WK     +   + ++ ++ G L I   
Sbjct: 135 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G+YTC  ++  G   +   +L V   P  +  P N  V   + V   C  +  P 
Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253

Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
             T  W +D+ ++       PR R  I  D +LR+  T   D G Y C+  N +     A
Sbjct: 254 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 304

Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356
           SA LTV   P  V+R               C  + NP P +F  W K+G    L  FP  
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 360

Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405
            Q           G L I        G Y C   T   S+       VT VL   PP  I
Sbjct: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462
            +        V    L+ C A GDP PV+SW K G    G   +A +    +L ++ L  
Sbjct: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480

Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509
              G + C A+++    + S  + V  +   +  N  +  LP                 +
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540

Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569
           SW+PG  G       +    +      + + W ++A  V      V GL+P+T Y F V 
Sbjct: 541 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 596

Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619
           A N  G     P S+ V +       +P A G+   ++   L    G V VR       T
Sbjct: 597 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 648

Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674
           P  V + W   +  P+ + GY +      G Q +  W+ LD  V  TE   ++  L K V
Sbjct: 649 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 706

Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734
            YE ++  +   F    S +  V T+         + P   PQ V    VG      ++V
Sbjct: 707 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 758



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  V+ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 30  PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       G Y C A +  G A   +A+  + L        P +  V A +
Sbjct: 89  SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              L C         T  W +D +    I   + R+ I   G L +  T+  DAG YTCV
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 204

Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347
            +N +    S  A LTV   P  +R P+                   P   V W KD   
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264

Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
           L   ++       + +L I        G Y C   N +G    S    V  +APP F+ R
Sbjct: 265 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 319

Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457
           P+++   + GR +  PC  +G+P P V W K G          +    +  V     L +
Sbjct: 320 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378

Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517
             + +   G++ C A      +     + V      +      + L   AN +     DG
Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 433

Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567
             L +      PL          W+            A       L +  L+      ++
Sbjct: 434 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487

Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627
            +A +  G   +S ++     G      +     +++P P S P+  V   T   V L W
Sbjct: 488 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 542

Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685
            P          Y++E   +  S  W+ +   V    T   V GL  + +Y F + A   
Sbjct: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 600

Query: 686 SFVSDPS 692
             +SDPS
Sbjct: 601 QGLSDPS 607



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%)

Query: 29  VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
           VV  AGE  +L C   PP G P    I W +                RID D   R+ + 
Sbjct: 142 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 183

Query: 89  KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
           +G  L I   R  D G Y C    +      D         LTV   P F   P   + +
Sbjct: 184 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 237

Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
           +E E V  RC  +G P P V WK    DL +G+  ++  + TLRI++      G Y C A
Sbjct: 238 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 295

Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
            +  G    +  L V  PP  VV P++  V   + V+  C  +  P    +   + + N 
Sbjct: 296 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 355

Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
           +F     QP  R  V   G L +   Q  DAG Y C     +  +L       +  LT  
Sbjct: 356 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415

Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
             P +++ P                    PL  +SW K+G      + P  +   +G+L 
Sbjct: 416 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 474

Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
           I        G Y+C   +S G    S V  V
Sbjct: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 505



 Score = 37.4 bits (85), Expect = 0.084
 Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%)

Query: 23  KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80
           +P  + + G A +++ + G  LL   A   PL VI WL+ GF  P            DP 
Sbjct: 415 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 463

Query: 81  YVGRVRLQKGASLQIEGLRVEDQGWYEC 108
              R  +Q+  +LQI+ LR+ D G Y C
Sbjct: 464 ---RATIQEQGTLQIKNLRISDTGTYTC 488


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  130 bits (326), Expect = 9e-30
 Identities = 178/725 (24%), Positives = 282/725 (38%), Gaps = 108/725 (14%)

Query: 154 VTLRCVARGSP-LPHVTWKLRGKDL--GQGQGQVQVQNGTLRIRRV-----ERGSSGVYT 205
           V L C A     +P + WK  G  L  G  + + Q+ NG+L I+ +      +   G+Y 
Sbjct: 57  VLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQ 116

Query: 206 CQASSTEGSA--THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
           C+AS  +  +  +   ++ V GP   +   ++ T      V L C     P   T  W +
Sbjct: 117 CEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMP-TIHWQK 175

Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMP 323
           +  ++  I     RV +L  G+L++   QP D G Y C   N         A + +L  P
Sbjct: 176 NQQDLTPIPG-DSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDP 234

Query: 324 G----------------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTE 361
           G                      V+ C V   PP  F +W +  + +QL +   +S    
Sbjct: 235 GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF-TWLRGEEVIQL-RSKKYSLLGG 292

Query: 362 GSLIIALGNEDALGEYSC-TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
            +L+I+   +D  G Y+C   Y +   +  + +T   +  PP F+  P   Y  E   ++
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELT---VLVPPWFLNHPSNLYAYE-SMDI 348

Query: 421 LIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478
              C+  G P P V+W K G  +      Q+   S+L +  + K   G ++C A N    
Sbjct: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGN 408

Query: 479 VATSTNVY----------VLGTSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWY 527
             TS  +           VL ++P  V  V V+   +   +SW P  +  G +Q F+V++
Sbjct: 409 AQTSAQLIVPKPAIPSSSVLPSAPRDV--VPVLVSSRFVRLSWRPPAEAKGNIQTFTVFF 466

Query: 528 TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAP 587
           +      +R  +         G+  L V  L+P   Y F V+A N+ G G  S+ +  A 
Sbjct: 467 SREGDNRERALN-----TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521

Query: 588 EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQ 646
           +           P  ++P P+     L AV T P  +L+ W+PP      + GY L   +
Sbjct: 522 Q-----------PELQVPGPV---ENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTE 567

Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNT---------A 695
            S G E  +  V G   +L   GL K   Y  R +A+   G  VS    T         A
Sbjct: 568 VSTGKE-QNIEVDGLSYKL--EGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA 624

Query: 696 NVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRK 755
                 LEV  SR+     LP P  +G   G            + G  +  R+  RR   
Sbjct: 625 PPQNVSLEVVNSRSIKVSWLPPP--SGTQNG-----------FITGYKIRHRKTTRRGEM 671

Query: 756 RLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHP 815
              +   L +  TG        GS     V+ + + G+  PS   +    +     S  P
Sbjct: 672 ETLEPNNLWYLFTGLEK-----GSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726

Query: 816 DPPSS 820
           D PSS
Sbjct: 727 DQPSS 731



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 187/772 (24%), Positives = 286/772 (37%), Gaps = 118/772 (15%)

Query: 28  SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGF-LLPIFIQFGLYSPRIDPDYVGRVR 86
           SV    G++V+L C+++      P+  I W +    L PI            P     V 
Sbjct: 148 SVTAFMGDTVLLKCEVIGE----PMPTIHWQKNQQDLTPI------------PGDSRVVV 191

Query: 87  LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP------QFQE 140
           L  GA LQI  L+  D G Y C         P      G+   + + S P       F +
Sbjct: 192 LPSGA-LQISRLQPGDIGIYRCSA-----RNPASS-RTGNEAEVRILSDPGLHRQLYFLQ 244

Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVER 198
            P  V+ ++  + V L C   G P P  TW LRG+++ Q + +     G   L I  V  
Sbjct: 245 RPSNVVAIEGKDAV-LECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNVTD 302

Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258
             SG+YTC  +    + + + +L VL PP  +  P N     S D+   C     P   T
Sbjct: 303 DDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP-T 361

Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN---------GLLH 309
            +W ++   V      Q    I+   +LR+L     D G Y CV  N          L+ 
Sbjct: 362 VNWMKNGDVVIPSDYFQ----IVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417

Query: 310 PPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKA---LQL----------DKFPGW 356
           P  A    +VL        PV  +   + +SW    +A   +Q           ++    
Sbjct: 418 PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERAL 477

Query: 357 SQGTEGSLIIALGN--EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQ 414
           +    GSL + +GN   +A+  +    YN  G    S   +V  + P   +  P E   Q
Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ-PELQVPGPVEN-LQ 535

Query: 415 EVG---RELLI----PCSAQGDPPPVVSW----TKVGRGLQGQAQVDSNSSLILRPLTKE 463
            V      +LI    P  A G   PV  +    T+V  G +   +VD   S  L  L K 
Sbjct: 536 AVSTSPTSILITWEPPAYANG---PVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKF 591

Query: 464 AHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSV-VALPKGANVSWEP---GFD 516
                   A N      ++ ++ V+  S        NVS+ V   +   VSW P   G  
Sbjct: 592 TEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQ 651

Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576
            G++  + + +    +R +      +    P    +L   GL+  +QY F V A    G+
Sbjct: 652 NGFITGYKIRHRKTTRRGE------METLEPNNLWYLFT-GLEKGSQYSFQVSAMTVNGT 704

Query: 577 GPFSE-IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
           GP S       PE          L  +++P     P  L        +++ W PP     
Sbjct: 705 GPPSNWYTAETPEN--------DLDESQVP---DQPSSLHVRPQTNCIIMSWTPPLNPNI 753

Query: 636 RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVS--DP 691
            + GY++    GS   E +   V   +    +  L     Y   L AF  AG  V   + 
Sbjct: 754 VVRGYIIGYGVGSPYAETV--RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811

Query: 692 SNTANVS--TSGLEVYPSRTQLPGLLPQ---PVLAGV-VGGVCFLGVAVLVS 737
           + T +++  T  ++ YP     P  +P    P+L  V V  V     AV VS
Sbjct: 812 ATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVS 863



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 114/537 (21%), Positives = 175/537 (32%), Gaps = 104/537 (19%)

Query: 557  GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616
            GL+P+T Y+FSV+      S  +S    +      T  AAP   P ++         +  
Sbjct: 909  GLKPNTMYEFSVMVTKNRRSSTWSMTAHAT-----TYEAAPTSAPKDLTV-------ITR 956

Query: 617  VRTPRGVLLHWDPPELVPKRLDGYV----LEGRQGSQGWEVLDPAVAGTETELLVPGLIK 672
               PR V++ W PP     ++  Y+    L+       W  +   ++G      +  L  
Sbjct: 957  EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDW--IMETISGDRLTHQIMDLNL 1014

Query: 673  DVLYEFRL--------------VAFAGSFVSDPSNTAN-----------------VSTSG 701
            D +Y FR+              + F    V  P   AN                 +  S 
Sbjct: 1015 DTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRST 1074

Query: 702  LEVYPSRTQLP---GLLPQPVLAGVVGGVCFLGV-AVLVSILAGCLLNRRRAARRRRKRL 757
            L   P     P    + PQ     +V  V  +GV  VLV ++   +  RR +A++R+KR 
Sbjct: 1075 LNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRA 1134

Query: 758  RQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDP 817
                            P          +  ++      P+ R S +      TP  H   
Sbjct: 1135 THSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQS 1194

Query: 818  PSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSP-- 875
             +  G         G D          +      R  A  R P  +L    D  S++P  
Sbjct: 1195 ETQLGSKSTSH--SGQDTE-----EAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAV 1247

Query: 876  -SGAPQPLCIEDISPVAPPPAAPPSPLPG-PGPLLQYLSLPFFREMNVD----------- 922
             S  P P         A  P   PSP  G P P      +P F  ++VD           
Sbjct: 1248 VSAIPVPTL-----ESAQYPGILPSPTCGYPHPQFTLRPVP-FPTLSVDRGFGAGRSQSV 1301

Query: 923  GDWPPLEEPS--PAAPPDYMDTRRCPTSSF----------LRS---PETPP----VSPRE 963
             + P  ++P   P + P++  +   P+ +           LRS   P  PP    + P+ 
Sbjct: 1302 SEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKV 1361

Query: 964  SLPGAVVGAGATAEPPYTALADWTL----RERLLPGLLPAAPRGSLTSQSSGRGSAS 1016
                 +   G T    +   A   L    R  LLP  +P AP  S  S      SA+
Sbjct: 1362 PYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSAN 1418



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 24/96 (25%), Positives = 43/96 (44%), Gaps = 4/96 (4%)

Query: 490  TSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPV 548
            ++P  +T ++    P+   VSW+P  +  G +  + ++YT     P     DW+   +  
Sbjct: 946  SAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPI---DDWIMETISG 1002

Query: 549  GAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584
                  +  L   T Y F + A+N  G GP S+ +L
Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPIL 1038


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  125 bits (313), Expect = 3e-28
 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)

Query: 29   VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
            VVG A   +VL C +       P   I W R G +L      QF                
Sbjct: 2400 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2440

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
             ++G  LQ++ L   D G Y C            + A  + V   + +++ P  +  PPA
Sbjct: 2441 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2490

Query: 145  VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
            V  V   +   L C A G P P V+W+     L     + ++   G+LRI+ V    +G 
Sbjct: 2491 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549

Query: 204  YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
            Y C AS++ GS      L VL PP I   P N T+ A     L C A   P  L   W  
Sbjct: 2550 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2609

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
                 F +   Q   R+L   +L L A  P D+  + CV SN +          +H P  
Sbjct: 2610 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667

Query: 314  SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
             A     +   +  P V+ C      P   VSW+K G  L   +  G+     G+L I  
Sbjct: 2668 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2725

Query: 369  GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
                  G Y+C+  NS G A       V L    + + +P     + V   E+L+PC A 
Sbjct: 2726 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781

Query: 428  GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
            G P P ++W K G  +      QV     L +   + E  G++ C A N+       T +
Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841

Query: 486  YVLGTSPHVVTN 497
             V    P V+ N
Sbjct: 2842 VV--QVPPVIEN 2851



 Score =  116 bits (290), Expect = 1e-25
 Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%)

Query: 128  VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
            V LTV + P  +  P  V  V E E V L C A G P P +TW+  G ++  G     + 
Sbjct: 2749 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2807

Query: 188  NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
             G LRI       +G Y C A ++ GSA   T+L+V  PPVI     + +        L 
Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2867

Query: 248  CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
            C A   P  N+T  W +D   V   S  + +  I   G L +   +  DAG YTC   N 
Sbjct: 2868 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2922

Query: 307  LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
             +       +LT+L +P                  +RC  R +P    + WT + + +  
Sbjct: 2923 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2979

Query: 351  DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
                G S+   GS +   A+  ED+ G Y C   N +G      V+ V +K  P      
Sbjct: 2980 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 3033

Query: 409  KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
                 + VG  + + C  +GDP P + W K G  L+G        N SL +    ++  G
Sbjct: 3034 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 3093

Query: 467  HWECSASNAVARVATSTNVYVLGTSP 492
             ++C A N +  VA    + VL ++P
Sbjct: 3094 RYQCLAENEMG-VAKKVVILVLQSAP 3118



 Score =  108 bits (270), Expect = 3e-23
 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)

Query: 24   PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
            P VV  V  A E V+L C+    A   P   I W + G  +   +               
Sbjct: 2763 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2802

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
              ++  G  L+I     ED G Y C        I ++   +      L V  PP  +   
Sbjct: 2803 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2853

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
            P  L   E     L C ARGSP P++TW   G+ +   +G+  +Q +G L ++ +E   +
Sbjct: 2854 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2912

Query: 202  GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
            G YTC A +  G A     L +L  PV    P + ++     + L C A   P       
Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972

Query: 262  FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
              D      +S            +L+  A   +D+G Y C   N +    + S       
Sbjct: 2973 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 3026

Query: 315  --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
                    +YL V  + G I+  C VR +P +  + W KDG  L+        Q   GSL
Sbjct: 3027 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 3082

Query: 365  IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
             I     D  G Y C   N +G A    V  ++L++ P F   P++   +  G ++ + C
Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3139

Query: 425  SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
             A G+P P + W + G+ L+   ++ +  + SL L  +     G ++C A N +      
Sbjct: 3140 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3199

Query: 483  TNVYVLG 489
              + V G
Sbjct: 3200 AFLVVRG 3206



 Score =  108 bits (269), Expect = 4e-23
 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
            L +G  LQI+  +V D G Y C    +     +D        ++ +  PP FQ       
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1550

Query: 140  ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
                     E    V E +E+    P  L C     P P +TW    + L  G     +Q
Sbjct: 1551 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1610

Query: 188  NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
             G  L+I  V   ++G Y+C+AS+  G      +LLVL PPVI+       +  TVNAS 
Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1670

Query: 243  DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
             VSL C A   P   T SW Q+ +         PR+++L DG  L++   +  DA  Y C
Sbjct: 1671 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725

Query: 302  VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
            V  N            +  PP  +      +T +    V + C V A+P    V+W KD 
Sbjct: 1726 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1784

Query: 346  KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
            +AL L +      GT  +L +        G Y+C   N+ G      + ++ +  PPAF 
Sbjct: 1785 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1841

Query: 406  ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
            + P+   +     VG + ++ C     P P V+W K G+ L   Q    +     L ++ 
Sbjct: 1842 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1901

Query: 460  LTKEAHGHWECSASNAVARVATSTNVYV 487
                  G + C  SN       +  + V
Sbjct: 1902 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1929



 Score =  106 bits (264), Expect = 1e-22
 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)

Query: 34   GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
            G+ V L C+     G+PP  V  WL+ G            SP +  D    +R    G S
Sbjct: 2041 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 2083

Query: 93   LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
            L ++GLR  D G Y C       H P  + A    V++ V  PP  ++       L  + 
Sbjct: 2084 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2136

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
             E VT+ C  RGSP  HV+W   G  L   Q  +   +G TLRI +V+   +G++TC A+
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196

Query: 210  STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
            S  G A     L V  PPV+  V    +  V     V L C A   P  L  SW +D   
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2255

Query: 268  VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
            +   S  Q         SL+L A    D+G Y+CV  +            ++ PP    S
Sbjct: 2256 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308

Query: 315  AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
               T L +    P  + C  +  P    ++W KDG+A  L +    S+ T       L  
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2360

Query: 371  EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
             DA G Y+C   +  G    S   RV ++APP  +  P+   F  VG    +L++ CS +
Sbjct: 2361 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2415

Query: 428  GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
             +P P ++W + G  LQ  A     +    L L+ L+    G + C+A NA    + +  
Sbjct: 2416 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475

Query: 485  VYVLGTSPHVVTNVSVVALPKGANVS 510
            V +     H V  +   + P   NVS
Sbjct: 2476 VEI-----HTVPTIR--SGPPAVNVS 2494



 Score =  103 bits (257), Expect = 1e-21
 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)

Query: 26   VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
            V  V   A  +V L C    PA   P+  I WL+ G  LP        SPR+        
Sbjct: 1661 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1703

Query: 86   RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
             L+ G  LQ+    V D   Y C        + E+   +   +  L V  PP+      E
Sbjct: 1704 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754

Query: 141  TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
               A+L       V+L C     P P VTW    + L  G+ +V +  GT  L++ R   
Sbjct: 1755 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1809

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
              SG+YTC+A +  G      QL VL PP     P+       V       L+C  +A P
Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869

Query: 255  ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
               T +W++D   +     L  R + L  G  L +   Q  D G Y+C  SN        
Sbjct: 1870 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1924

Query: 306  --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
                         P       V   P V+ C V +  P   V+W KD   ++     G  
Sbjct: 1925 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1983

Query: 357  SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
            S+G  G L ++       G Y+C   N+   A    V  VL+ AP         E+    
Sbjct: 1984 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 2040

Query: 417  GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
            G+E+ + C A G PPP V+W K G  L GQ             SL+L+ L     G + C
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099

Query: 471  SASNAVARVATSTNVYVL 488
             A N     A    V VL
Sbjct: 2100 VAHNPAGEDARLHTVNVL 2117



 Score =  102 bits (253), Expect = 3e-21
 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
            G  L +   ++  +G Y C    +  +  +D       + L V+ PPQ      PP  + 
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 1078

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
            V +    TL C A G P P VTW+  G+ +G   G Q+Q Q  +L + R +   +G Y+C
Sbjct: 1079 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138

Query: 207  QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
             A +  G A    +L VL PP ++    P  N T      ++L C A   P      WF+
Sbjct: 1139 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1197

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
                V   S  +    +     L++  TQ  D+G Y+C+ SN            +L PPS
Sbjct: 1198 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1254

Query: 313  -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
                     + VL      + C V  +P P L  +W KDG+ L   +        +G L+
Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1310

Query: 366  IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
              L  N  + G YSC   N++G         VLL AP       +   EE    V   + 
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1369

Query: 422  IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
            + C A   P P ++W K G   +    +        L +    KE  G + C  +N +  
Sbjct: 1370 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1429

Query: 479  VATSTNVYVL 488
               + +V VL
Sbjct: 1430 AVKNYHVEVL 1439



 Score =  101 bits (252), Expect = 4e-21
 Identities = 121/434 (27%), Positives = 177/434 (40%), Gaps = 59/434 (13%)

Query: 91   ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
            A LQ++   V D G Y C    L+Q    +   N     L V   P F       L V+E
Sbjct: 933  ALLQVDRADVWDAGHYTCEA--LNQAGRSEKHYN-----LNVWVAPVFPLRESHTLTVRE 985

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
              P +L C  RG P P ++W+  G+ L G+G G   V      L + + +    G YTC+
Sbjct: 986  GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045

Query: 208  ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
             S+  G+++   QL V  PP I  P +  T V+  QD   +L C+A   P   T +W +D
Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1104

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
               V     LQ + +     SL +   Q    G Y+CV  N            +L PP  
Sbjct: 1105 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161

Query: 314  SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
               L         L  P  + C     PP   + W +  + +     PG     E + ++
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1211

Query: 367  ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
            A G         E   G YSC   N  G A  +    VL+  PP+      EE  + + G
Sbjct: 1212 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1269

Query: 418  RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
            +   + C+  G P P ++W K GR L +G A   S   ++L+ L     + GH+ C A+N
Sbjct: 1270 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329

Query: 475  AVARVATSTNVYVL 488
            AV        + VL
Sbjct: 1330 AVGEKTKHFQLSVL 1343



 Score =  100 bits (249), Expect = 8e-21
 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)

Query: 88  QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
           + G  L+I G  V D+G Y+C V F        DF       L V++PP  +       +
Sbjct: 269 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 321

Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
            V E   V L C ARG P P++TW   G  L      V  + G  L++ R +   +GVYT
Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381

Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
           C+AS+  G+A  AT+L V  PP I      P      A + V+L C A  +P+  T SW 
Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 440

Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
            + + V   +      R+  DGS LRL +     +G Y+CV S+                
Sbjct: 441 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 496

Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
             LL         T++  P  + C   +  P+  + W ++G+ A +L      SQGT  +
Sbjct: 497 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 553

Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
           L I     D  G ++C   N  GTAG      V  +  P  +E P  +Y          P
Sbjct: 554 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 613

Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
            +          A   PP V  W   G  L G+      +  +  PL  E       G +
Sbjct: 614 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672

Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
            C+A+N          + VL   P++       A+ + A+V+ E    G      S W+ 
Sbjct: 673 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 729

Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
               +  +    W+ + V V    L +   Q      +  +A N  GS      + ++ P
Sbjct: 730 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 785

Query: 588 EGLPTTPAAPG 598
             +   P+ PG
Sbjct: 786 PRITLPPSLPG 796



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 131/517 (25%), Positives = 201/517 (38%), Gaps = 77/517 (14%)

Query: 13  VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
           V+    + +  P+++   G    + ++G  L  P  A   P+  I+WL+ G         
Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 536

Query: 71  GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
                R   +  G     +G +L I+ + ++  G + C+          +    G+ V +
Sbjct: 537 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 584

Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
           +V+      E  P VLEV         +        C   V RG    P P +   W   
Sbjct: 585 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 639

Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
           G   G+  G     +    L+I +V+    G+YTC A++  G +     L VL PP I  
Sbjct: 640 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 699

Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
            P N  V  +  V+L C A   P     SWF+ +  V         V + VDG  LR+  
Sbjct: 700 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 754

Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
            Q  DAG Y CV SN         GL ++ P        L  P ++  PVR        P
Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 814

Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
              + W KDG  +     PG      G  L +A       G YSC   +++G      V 
Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 874

Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
           +V +  PP+ +   +E     V  E + + C +   PPPV+SW K GR L+ +  V  ++
Sbjct: 875 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 930

Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
              L  + +      GH+ C A N   R     N+ V
Sbjct: 931 DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)

Query: 16   QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
            Q A  R  P  VSVV        L C+     G+PP   + W R G   P+  + GL   
Sbjct: 1066 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1114

Query: 76   RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
                      +LQ +G SL +E  +    G Y C    L                L+V  
Sbjct: 1115 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1157

Query: 135  PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
            PP+      P   +      P+TL C A G P P + W    + +  G+    +  G  L
Sbjct: 1158 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1217

Query: 192  RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
            ++ + +   SG+Y+C AS+  G A     + VL PP I        +     Q   L C+
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277

Query: 250  AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
               +P     +WF+D       +  HIS          DG L ++L      AG Y+C+ 
Sbjct: 1278 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1327

Query: 304  SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
            +N +    +    L+VL  P ++            V  N P+  +           +W K
Sbjct: 1328 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386

Query: 344  DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            DG   +  +      GT G  I+    EDA G+Y+C   N LG A  +    VL+  PP+
Sbjct: 1387 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1443

Query: 404  FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
                    E   +E   +V   L + C +   PPP + W K G+ +    + QV     L
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1503

Query: 456  I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
            + ++P      G + C A+N         NV +
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 114/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
            G  L+IE  ++ D G Y C            + A  + +   L VN PP+    P     
Sbjct: 747  GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 797

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
            V    PV L C A G+P P + W   G  +   G   +QV  G   L +       SG Y
Sbjct: 798  VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
            +C A S  G       L V  PP I+    N +V A++ V+L C + A P  +  SW++D
Sbjct: 858  SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 916

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSN---------------G 306
                     L+PR  + +     LL        DAG YTC   N                
Sbjct: 917  G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA 970

Query: 307  LLHPPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
             + P   S  LTV    P  + C  R   P   +SW KDG+ L     PG   G +    
Sbjct: 971  PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 1024

Query: 363  -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
               ++ LG       G Y+C   N +G +       V +    A    P  +        
Sbjct: 1025 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 1084

Query: 420  LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
              + C+A G PPP V+W + G+  G +   Q+ +    +     + AH G + C A N  
Sbjct: 1085 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1144

Query: 477  ARVATSTNVYVL 488
             R      + VL
Sbjct: 1145 GRAERKFELSVL 1156



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 189/772 (24%), Positives = 269/772 (34%), Gaps = 158/772 (20%)

Query: 145 VLEVQELEPVTLR-------CVARGSPLPHVTWKL--RGKDLGQGQGQVQVQNGTLRIRR 195
           VLE++ L  V L        C   G+P P VTW+     + L    G   ++ G+L +  
Sbjct: 4   VLEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLAS 63

Query: 196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAY 253
           V    SG Y CQA++  GS +   +L+V  PP I    + + V+  A Q ++L C A  +
Sbjct: 64  VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123

Query: 254 P---------ANLT--------YSW-----------FQDNINVFHISRLQP----RVRIL 281
           P         A L         Y W             D     H  R+QP    R    
Sbjct: 124 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183

Query: 282 VDGSLRLLATQPDDAGCYTCVPSNGLLHPPS------ASAYLTVLCMPGV---IRCPVRA 332
             GS +  A        +   P+     PP+      A A   VL + G    ++C   +
Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC-WTS 242

Query: 333 NPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPS 391
             P   V WTKD + + L   P      +G ++   G+     G Y C  ++  G     
Sbjct: 243 GVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 301

Query: 392 PVTRVLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV 449
              RV   APP  I    E     V  + L+   C A+G P P ++W K G  L    +V
Sbjct: 302 FQLRV--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV 358

Query: 450 ---DSNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALP 504
                   L L        G + C ASNAV  A  AT  +VYV  T         VV   
Sbjct: 359 VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418

Query: 505 KGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY 564
            G  V+ E    G      S W           HH+     +PV  ++      +   + 
Sbjct: 419 AGRPVALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLET 456

Query: 565 QFSVL---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621
             SVL   +  +  SG +S  V S+P G      +      ++PP L    GL  V T  
Sbjct: 457 DGSVLRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIV 512

Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYE 677
           G      P EL P +  G  +   Q    G    E+    VA   T L +  +  D    
Sbjct: 513 G-----QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD---- 562

Query: 678 FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVS 737
                 +G F    +N A  + + +EV       PG+L  P+      G    G     S
Sbjct: 563 -----HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSS 611

Query: 738 ILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPS 797
             A C                 DPP+          P   G  SP S             
Sbjct: 612 FPAAC-----------------DPPVHRGWGAHPKPPLVEGWCSPGS------------- 641

Query: 798 LRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849
                LWG+P G P  +  PP    PL +E +    +G +    T  A + +
Sbjct: 642 -----LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 684



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
            R +LQ G SL I     +D G Y+C        + E++      V + V  S P FQ   
Sbjct: 3074 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3123

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
            P  + V+  + V LRC A G P P + W   G+ L   +    + +G+L +  VE G +G
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183

Query: 203  VYTCQASSTEGSATHATQLLVLGPP 227
             Y C A +  GSAT    L+V G P
Sbjct: 3184 TYDCVAHNLLGSATARAFLVVRGEP 3208



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%)

Query: 93   LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
            LQI   + ED G Y C V   L + +           H+ V  PP   +  P     V E
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 1457

Query: 148  VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
            V+      +TL C +   P P + W   G+ +      QV  +   L+I+  +   SG Y
Sbjct: 1458 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1517

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
             C A++  G       +L+  PP+       S                     +  +   
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577

Query: 245  SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
             L C   A P     +W++++  +         V +L  G  L++   + ++AG Y+C  
Sbjct: 1578 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1632

Query: 304  SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
            SN            +L PP            +TV     V ++CP   N P+  +SW ++
Sbjct: 1633 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1691

Query: 345  GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            G  L     P      +G ++ ++         Y C   N  G+A      RV  + PP 
Sbjct: 1692 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1747

Query: 404  FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
                  E+    +   + +PC     P P V+W K  + L    +V       +L L   
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807

Query: 461  TKEAHGHWECSASNAVAR 478
                 G + C A NA  R
Sbjct: 1808 RLSDSGMYTCEALNAAGR 1825


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  125 bits (313), Expect = 3e-28
 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)

Query: 29   VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
            VVG A   +VL C +       P   I W R G +L      QF                
Sbjct: 3591 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 3631

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
             ++G  LQ++ L   D G Y C            + A  + V   + +++ P  +  PPA
Sbjct: 3632 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 3681

Query: 145  VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
            V  V   +   L C A G P P V+W+     L     + ++   G+LRI+ V    +G 
Sbjct: 3682 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740

Query: 204  YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
            Y C AS++ GS      L VL PP I   P N T+ A     L C A   P  L   W  
Sbjct: 3741 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 3800

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
                 F +   Q   R+L   +L L A  P D+  + CV SN +          +H P  
Sbjct: 3801 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858

Query: 314  SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
             A     +   +  P V+ C      P   VSW+K G  L   +  G+     G+L I  
Sbjct: 3859 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 3916

Query: 369  GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
                  G Y+C+  NS G A       V L    + + +P     + V   E+L+PC A 
Sbjct: 3917 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972

Query: 428  GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
            G P P ++W K G  +      QV     L +   + E  G++ C A N+       T +
Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032

Query: 486  YVLGTSPHVVTN 497
             V    P V+ N
Sbjct: 4033 VV--QVPPVIEN 4042



 Score =  116 bits (290), Expect = 1e-25
 Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%)

Query: 128  VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
            V LTV + P  +  P  V  V E E V L C A G P P +TW+  G ++  G     + 
Sbjct: 3940 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 3998

Query: 188  NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
             G LRI       +G Y C A ++ GSA   T+L+V  PPVI     + +        L 
Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 4058

Query: 248  CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
            C A   P  N+T  W +D   V   S  + +  I   G L +   +  DAG YTC   N 
Sbjct: 4059 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 4113

Query: 307  LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
             +       +LT+L +P                  +RC  R +P    + WT + + +  
Sbjct: 4114 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 4170

Query: 351  DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
                G S+   GS +   A+  ED+ G Y C   N +G      V+ V +K  P      
Sbjct: 4171 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 4224

Query: 409  KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
                 + VG  + + C  +GDP P + W K G  L+G        N SL +    ++  G
Sbjct: 4225 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 4284

Query: 467  HWECSASNAVARVATSTNVYVLGTSP 492
             ++C A N +  VA    + VL ++P
Sbjct: 4285 RYQCLAENEMG-VAKKVVILVLQSAP 4309



 Score =  113 bits (283), Expect = 9e-25
 Identities = 140/526 (26%), Positives = 199/526 (37%), Gaps = 102/526 (19%)

Query: 34   GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
            G S +L C      GRPP   + W R G   P+ ++ G            R R      L
Sbjct: 800  GRSALLACRA---TGRPP-PTVTWRR-GDGQPLGLRLGAGRG-------SRSRQPDSGVL 847

Query: 94   QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
              E +  EDQ  Y C    +   +  +     + + +T ++PPQ   + P V  V E +P
Sbjct: 848  FFESVAPEDQAPYVCEARNVFGKVQAE-----ARLIVTGHAPPQIASSAPTV-RVLEGQP 901

Query: 154  VTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
            V+L C+   G PLP   W   G+ L  G       +G+L + R  +  +G Y+C A++T 
Sbjct: 902  VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA 961

Query: 213  GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV---- 268
            GS     +L+V  PP I     +   N     SL C A   PA  T +W ++   +    
Sbjct: 962  GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP-TITWTKETNALTSRG 1020

Query: 269  --FHISR------LQPRVR--------------------------------------ILV 282
              +++S+       QP  +                                      +L 
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP 1080

Query: 283  DGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSAS---AYLTVLCMPGV-IR 327
             GSLRL   Q  D+G Y C  SN           G+  PP        L VL    + + 
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140

Query: 328  CPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG 386
            C    NP P L  SW+KDG  LQ        +G +GS+  A       G Y C   NS G
Sbjct: 1141 CVAEGNPEPQL--SWSKDGVVLQ-------GRGPQGSVHFAAIRTSDAGRYRCEASNSAG 1191

Query: 387  TAGPSPVTRVLLKAPPAFIERPKEEYFQEV-GRELLIPCSAQGDPPPVVSWTK--VGRGL 443
                    RVL   PP +         + V G    +PC A+G P P V+W K      L
Sbjct: 1192 VDAWEVELRVL--EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPL 1249

Query: 444  QGQ--AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
             GQ    V    SL L  ++    G +EC A+N V   +    + V
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295



 Score =  108 bits (271), Expect = 2e-23
 Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%)

Query: 28   SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
            +V G AG+S+ L CD    A   P+  I WL+   L+ + + +  Y   +    VG  RL
Sbjct: 1309 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364

Query: 88   -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
              +G SL    ++  D G Y CR         + DF      HL V +PP       A  
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 1416

Query: 147  EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
            EV  L    V L+C   G P P V W    + +  G   +QVQ     LRI     G  G
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476

Query: 203  VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
             Y C A S  G      QL V  PP I    +   V   +D  V L C A   P  N+T 
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 1535

Query: 260  SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308
             WF+D   +   +++   V       L+L   Q  DAG YTC  SN            + 
Sbjct: 1536 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591

Query: 309  HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360
             PP+             V   P  + C  R +P P L  SW  +G  L + +       T
Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 1647

Query: 361  EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
            +GS++ +    E + G YSC   +  G A       V +  P   +     +    VG+ 
Sbjct: 1648 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 1706

Query: 420  LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
            L +PC A G P P + W + GR    L G       ++L +  +  +  G + C A+N  
Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766

Query: 477  ARVATSTNVYVLG 489
                    V V G
Sbjct: 1767 GTAGAEVEVSVHG 1779



 Score =  108 bits (270), Expect = 3e-23
 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)

Query: 24   PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
            P VV  V  A E V+L C+    A   P   I W + G  +   +               
Sbjct: 3954 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 3993

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
              ++  G  L+I     ED G Y C        I ++   +      L V  PP  +   
Sbjct: 3994 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 4044

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
            P  L   E     L C ARGSP P++TW   G+ +   +G+  +Q +G L ++ +E   +
Sbjct: 4045 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 4103

Query: 202  GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
            G YTC A +  G A     L +L  PV    P + ++     + L C A   P       
Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163

Query: 262  FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
              D      +S            +L+  A   +D+G Y C   N +    + S       
Sbjct: 4164 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 4217

Query: 315  --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
                    +YL V  + G I+  C VR +P +  + W KDG  L+        Q   GSL
Sbjct: 4218 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 4273

Query: 365  IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
             I     D  G Y C   N +G A    V  ++L++ P F   P++   +  G ++ + C
Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 4330

Query: 425  SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
             A G+P P + W + G+ L+   ++ +  + SL L  +     G ++C A N +      
Sbjct: 4331 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 4390

Query: 483  TNVYVLG 489
              + V G
Sbjct: 4391 AFLVVRG 4397



 Score =  108 bits (269), Expect = 4e-23
 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
            L +G  LQI+  +V D G Y C    +     +D        ++ +  PP FQ       
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 2741

Query: 140  ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
                     E    V E +E+    P  L C     P P +TW    + L  G     +Q
Sbjct: 2742 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 2801

Query: 188  NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
             G  L+I  V   ++G Y+C+AS+  G      +LLVL PPVI+       +  TVNAS 
Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 2861

Query: 243  DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
             VSL C A   P   T SW Q+ +         PR+++L DG  L++   +  DA  Y C
Sbjct: 2862 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916

Query: 302  VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
            V  N            +  PP  +      +T +    V + C V A+P    V+W KD 
Sbjct: 2917 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 2975

Query: 346  KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
            +AL L +      GT  +L +        G Y+C   N+ G      + ++ +  PPAF 
Sbjct: 2976 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 3032

Query: 406  ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
            + P+   +     VG + ++ C     P P V+W K G+ L   Q    +     L ++ 
Sbjct: 3033 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 3092

Query: 460  LTKEAHGHWECSASNAVARVATSTNVYV 487
                  G + C  SN       +  + V
Sbjct: 3093 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 3120



 Score =  106 bits (264), Expect = 1e-22
 Identities = 111/419 (26%), Positives = 166/419 (39%), Gaps = 45/419 (10%)

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
            R+ +    +L I+G+  ED G Y C+          +   +   V L    PP       
Sbjct: 653  RIHVDAQGTLIIQGVAPEDAGNYSCQA-------TNEVGTDQETVTLYYTDPPSVSAVNA 705

Query: 144  AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSG 202
             VL V   E   L C A G P P V W   G ++    +G     +G LRI   +   +G
Sbjct: 706  VVL-VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGKLRIPAAQERDAG 761

Query: 203  VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
             YTC+A +  G A+   QL V   P +   P++ TV   +   LAC A   P   T +W 
Sbjct: 762  TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTWR 820

Query: 263  QDNINVFHI---SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-------------- 305
            + +     +   +    R R    G L   +  P+D   Y C   N              
Sbjct: 821  RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 880

Query: 306  GLLHPPSASAYLTVLCMPGV---IRCPVRANPPLLFVSWTKDGKALQLDKFPG--WSQGT 360
            G   P  AS+  TV  + G    + C V A  PL    W KDG+ L     PG   S   
Sbjct: 881  GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP----PGSRHSIRA 936

Query: 361  EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
            +GSL +    ++  G YSC   N+ G+        ++++ PP  I      +    G   
Sbjct: 937  DGSLHLDRALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPR-IHPTATHHITNEGVPA 993

Query: 421  LIPCSAQGDPPPVVSWTKVGRGLQGQA---QVDSNSSLILRPLTKEAHGHWECSASNAV 476
             +PC A G P P ++WTK    L  +     V    +L++   + +  G + C+A+N V
Sbjct: 994  SLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052



 Score =  106 bits (264), Expect = 1e-22
 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)

Query: 34   GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
            G+ V L C+     G+PP  V  WL+ G            SP +  D    +R    G S
Sbjct: 3232 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 3274

Query: 93   LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
            L ++GLR  D G Y C       H P  + A    V++ V  PP  ++       L  + 
Sbjct: 3275 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 3327

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
             E VT+ C  RGSP  HV+W   G  L   Q  +   +G TLRI +V+   +G++TC A+
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387

Query: 210  STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
            S  G A     L V  PPV+  V    +  V     V L C A   P  L  SW +D   
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 3446

Query: 268  VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
            +   S  Q         SL+L A    D+G Y+CV  +            ++ PP    S
Sbjct: 3447 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499

Query: 315  AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
               T L +    P  + C  +  P    ++W KDG+A  L +    S+ T       L  
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 3551

Query: 371  EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
             DA G Y+C   +  G    S   RV ++APP  +  P+   F  VG    +L++ CS +
Sbjct: 3552 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 3606

Query: 428  GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
             +P P ++W + G  LQ  A     +    L L+ L+    G + C+A NA    + +  
Sbjct: 3607 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666

Query: 485  VYVLGTSPHVVTNVSVVALPKGANVS 510
            V +     H V  +   + P   NVS
Sbjct: 3667 VEI-----HTVPTIR--SGPPAVNVS 3685



 Score =  103 bits (257), Expect = 1e-21
 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)

Query: 26   VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
            V  V   A  +V L C    PA   P+  I WL+ G  LP        SPR+        
Sbjct: 2852 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 2894

Query: 86   RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
             L+ G  LQ+    V D   Y C        + E+   +   +  L V  PP+      E
Sbjct: 2895 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945

Query: 141  TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
               A+L       V+L C     P P VTW    + L  G+ +V +  GT  L++ R   
Sbjct: 2946 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 3000

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
              SG+YTC+A +  G      QL VL PP     P+       V       L+C  +A P
Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060

Query: 255  ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
               T +W++D   +     L  R + L  G  L +   Q  D G Y+C  SN        
Sbjct: 3061 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 3115

Query: 306  --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
                         P       V   P V+ C V +  P   V+W KD   ++     G  
Sbjct: 3116 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 3174

Query: 357  SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
            S+G  G L ++       G Y+C   N+   A    V  VL+ AP         E+    
Sbjct: 3175 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 3231

Query: 417  GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
            G+E+ + C A G PPP V+W K G  L GQ             SL+L+ L     G + C
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290

Query: 471  SASNAVARVATSTNVYVL 488
             A N     A    V VL
Sbjct: 3291 VAHNPAGEDARLHTVNVL 3308



 Score =  103 bits (256), Expect = 1e-21
 Identities = 120/434 (27%), Positives = 175/434 (40%), Gaps = 59/434 (13%)

Query: 91   ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
            A LQ++   V D G Y C       H  E  +    WV       P F       L V+E
Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 2176

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
              P +L C  RG P P ++W+  G+ L G+G G   V      L + + +    G YTC+
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236

Query: 208  ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
             S+  G+++   QL V  PP I  P +  T V+  QD   +L C+A   P   T +W +D
Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 2295

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
               V     LQ + +     SL +   Q    G Y+CV  N            +L PP  
Sbjct: 2296 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352

Query: 314  SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
               L         L  P  + C     PP   + W +  + +     PG     E + ++
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 2402

Query: 367  ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
            A G         E   G YSC   N  G A  +    VL+  PP+      EE  + + G
Sbjct: 2403 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 2460

Query: 418  RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
            +   + C+  G P P ++W K GR L +G A   S   ++L+ L     + GH+ C A+N
Sbjct: 2461 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520

Query: 475  AVARVATSTNVYVL 488
            AV        + VL
Sbjct: 2521 AVGEKTKHFQLSVL 2534



 Score =  102 bits (254), Expect = 2e-21
 Identities = 221/888 (24%), Positives = 320/888 (36%), Gaps = 153/888 (17%)

Query: 14   ISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
            +  G  G  +    +  G A    VLG  + PP  +P   V++ L    L    +  G  
Sbjct: 1089 VQVGDSGHYECTASNPAGSASHRYVLGVQV-PPQVQPGPRVLKVLVGEALDLNCVAEGNP 1147

Query: 74   SPRIDPDYVGRVRLQKG--ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHL 130
             P++     G V   +G   S+    +R  D G Y C           +     +W V L
Sbjct: 1148 EPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA--------SNSAGVDAWEVEL 1199

Query: 131  TVNSPPQF-QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKL--RGKDLGQGQGQVQVQ 187
             V  PP +  +    +LE    E  +L C ARG+P P VTW+     + L    G   ++
Sbjct: 1200 RVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE 1259

Query: 188  NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVS 245
             G+L +  V    SG Y CQA++  GS +   +L+V  PP I    + + V+  A Q ++
Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319

Query: 246  LACHAEAYPANLTYSWFQDNINV----------FHISRLQPRVRILVD--GSLRLLATQP 293
            L C A  +P      W +D   V          + +   Q     L+D   SL     Q 
Sbjct: 1320 LECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378

Query: 294  DDAGCYTCVPSNG-----------LLHPPS---ASAYLTVLCMPGV---IRCPVRANPPL 336
             D+G Y+C   N            +L PPS   A A   VL + G    ++C   +  P 
Sbjct: 1379 GDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC-WTSGVPT 1437

Query: 337  LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPSPVTR 395
              V WTKD + + L   P      +G ++   G+     G Y C  ++  G        R
Sbjct: 1438 PQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLR 1496

Query: 396  VLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV---D 450
            V   APP  I    E     V  + L+   C A+G P P ++W K G  L    +V    
Sbjct: 1497 V--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR 1553

Query: 451  SNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508
                L L        G + C ASNAV  A  AT  +VYV  T         VV    G  
Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP 1613

Query: 509  VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
            V+ E    G      S W           HH+     +PV  ++      +   +   SV
Sbjct: 1614 VALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLETDGSV 1651

Query: 569  L---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLL 625
            L   +  +  SG +S  V S+P G      +      ++PP L    GL  V T  G   
Sbjct: 1652 LRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIVG--- 1704

Query: 626  HWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLV 681
               P EL P +  G  +   Q    G    E+    VA   T L +  +  D        
Sbjct: 1705 --QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD-------- 1753

Query: 682  AFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAG 741
              +G F    +N A  + + +EV       PG+L  P+      G    G     S  A 
Sbjct: 1754 -HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSSFPAA 1806

Query: 742  CLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQS 801
            C                 DPP+          P   G  SP S                 
Sbjct: 1807 C-----------------DPPVHRGWGAHPKPPLVEGWCSPGS----------------- 1832

Query: 802  LLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849
             LWG+P G P  +  PP    PL +E +    +G +    T  A + +
Sbjct: 1833 -LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 1875



 Score =  102 bits (253), Expect = 3e-21
 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
            G  L +   ++  +G Y C    +  +  +D       + L V+ PPQ      PP  + 
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 2269

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
            V +    TL C A G P P VTW+  G+ +G   G Q+Q Q  +L + R +   +G Y+C
Sbjct: 2270 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329

Query: 207  QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
             A +  G A    +L VL PP ++    P  N T      ++L C A   P      WF+
Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 2388

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
                V   S  +    +     L++  TQ  D+G Y+C+ SN            +L PPS
Sbjct: 2389 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 2445

Query: 313  -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
                     + VL      + C V  +P P L  +W KDG+ L   +        +G L+
Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 2501

Query: 366  IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
              L  N  + G YSC   N++G         VLL AP       +   EE    V   + 
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 2560

Query: 422  IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
            + C A   P P ++W K G   +    +        L +    KE  G + C  +N +  
Sbjct: 2561 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 2620

Query: 479  VATSTNVYVL 488
               + +V VL
Sbjct: 2621 AVKNYHVEVL 2630



 Score =  100 bits (249), Expect = 8e-21
 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)

Query: 88   QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
            + G  L+I G  V D+G Y+C V F        DF       L V++PP  +       +
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 1512

Query: 147  EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
             V E   V L C ARG P P++TW   G  L      V  + G  L++ R +   +GVYT
Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 1572

Query: 206  CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
            C+AS+  G+A  AT+L V  PP I      P      A + V+L C A  +P+  T SW 
Sbjct: 1573 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 1631

Query: 263  QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
             + + V   +      R+  DGS LRL +     +G Y+CV S+                
Sbjct: 1632 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 1687

Query: 306  -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
              LL         T++  P  + C   +  P+  + W ++G+ A +L      SQGT  +
Sbjct: 1688 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 1744

Query: 364  LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
            L I     D  G ++C   N  GTAG      V  +  P  +E P  +Y          P
Sbjct: 1745 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 1804

Query: 424  CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
             +          A   PP V  W   G  L G+      +  +  PL  E       G +
Sbjct: 1805 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 1863

Query: 469  ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
             C+A+N          + VL   P++       A+ + A+V+ E    G      S W+ 
Sbjct: 1864 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 1920

Query: 529  PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
                +  +    W+ + V V    L +   Q      +  +A N  GS      + ++ P
Sbjct: 1921 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 1976

Query: 588  EGLPTTPAAPG 598
              +   P+ PG
Sbjct: 1977 PRITLPPSLPG 1987



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%)

Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
           +P+ + C    S LP      RG+  LG+ +   +  N +  I R  +   G Y C A S
Sbjct: 442 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500

Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
             G+     Q++V  PP  +VP  N TV+  +   L+C    EA P NLT  W +D    
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 553

Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324
               R+ P    RV  L D SL +    P D G Y CV SN       AS +L V   P 
Sbjct: 554 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 609

Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367
           V                + C   +  P   +SW+++ +ALQ D         +G+LII  
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 666

Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427
           +  EDA G YSC   N +GT      T  L    P  +          VG E ++ C A 
Sbjct: 667 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 722

Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
           G PPP V W + G  +    +  S+  L +    +   G + C A N +   +    + V
Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782

Query: 488 LGTSPHV 494
            G +P +
Sbjct: 783 -GHAPQL 788



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%)

Query: 14  ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
           +S+   GR K ++V            +V    GE+ VL C +L   G  P + + W+R  
Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 552

Query: 62  FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
                         R+ P   GRV      SL+I G+   D G Y+C             
Sbjct: 553 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 590

Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
            ANG   + V L V   PQ      +    Q +E V + C A G P PH++W    + L 
Sbjct: 591 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 648

Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
           Q   ++ V   GTL I+ V    +G Y+CQA++  G+      L    PP +        
Sbjct: 649 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708

Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
           V   ++  L C A   P      W++  + +     L P       G LR+ A Q  DAG
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 761

Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341
            YTC   N  L   SA   L V                L    ++ C     PP   V+W
Sbjct: 762 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 819

Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
            + DG+ L L    G      Q   G L       +    Y C   N  G         V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879

Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453
              APP            E G+ + +PC    G P P   W K GR L    +  + ++ 
Sbjct: 880 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 938

Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502
           SL L    +E  G + C A+N          + V        T+ H +TN  V A
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 993



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 112/392 (28%), Positives = 153/392 (39%), Gaps = 65/392 (16%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH---LTVNSPPQFQETPP 143
            L    SL++  ++V D G YEC                GS  H   L V  PPQ Q   P
Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTA----------SNPAGSASHRYVLGVQVPPQVQ-PGP 1126

Query: 144  AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
             VL+V   E + L CVA G+P P ++W   G  L QG+G      G++    +    +G 
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGRG----PQGSVHFAAIRTSDAGR 1181

Query: 204  YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAYPANLTYSW 261
            Y C+AS++ G      +L VL PP       +  +   A ++ SL C A   P       
Sbjct: 1182 YRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241

Query: 262  FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLC 321
               +    H    QP V +L +GSL L +  P D+G Y C  +N  +   S  A L V  
Sbjct: 1242 KGPSSEPLH---GQPGVAVLEEGSLFLASVSPADSGDYECQATNE-VGSTSRRAKLVVYV 1297

Query: 322  MPGVIRCPVRANP-----------------PLLFVSWTKDGKALQLDKFP------GWSQ 358
             P +     +AN                  P+  + W KD    QL   P      GW  
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA---QLVGVPLGWAGYGWDL 1354

Query: 359  G----------TEG-SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI-E 406
            G           EG SL      E   G YSC   N  GTA       +L+  PP+ +  
Sbjct: 1355 GWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD--FHLLVLTPPSVLGA 1412

Query: 407  RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTK 438
               +E     G ++ + C   G P P V WTK
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
            G  L+IE  ++ D G Y C            + A  + +   L VN PP+    P     
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 1988

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
            V    PV L C A G+P P + W   G  +   G   +QV  G   L +       SG Y
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
            +C A S  G       L V  PP I+    N +V A++ V+L C + A P  +  SW++D
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 2107

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309
                     L+PR  + +     LL        DAG YTC   N   H            
Sbjct: 2108 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 2161

Query: 310  ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
               P   S  LTV    P  + C  R   P   +SW KDG+ L     PG   G +    
Sbjct: 2162 PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 2215

Query: 363  -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
               ++ LG       G Y+C   N +G +       V +    A    P  +        
Sbjct: 2216 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 2275

Query: 420  LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
              + C+A G PPP V+W + G+  G +   Q+ +    +     + AH G + C A N  
Sbjct: 2276 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 2335

Query: 477  ARVATSTNVYVL 488
             R      + VL
Sbjct: 2336 GRAERKFELSVL 2347



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)

Query: 16   QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
            Q A  R  P  VSVV        L C+     G+PP   + W R G   P+  + GL   
Sbjct: 2257 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 2305

Query: 76   RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
                      +LQ +G SL +E  +    G Y C    L                L+V  
Sbjct: 2306 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 2348

Query: 135  PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
            PP+      P   +      P+TL C A G P P + W    + +  G+    +  G  L
Sbjct: 2349 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 2408

Query: 192  RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
            ++ + +   SG+Y+C AS+  G A     + VL PP I        +     Q   L C+
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468

Query: 250  AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
               +P     +WF+D       +  HIS          DG L ++L      AG Y+C+ 
Sbjct: 2469 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 2518

Query: 304  SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
            +N +    +    L+VL  P ++            V  N P+  +           +W K
Sbjct: 2519 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577

Query: 344  DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            DG   +  +      GT G  I+    EDA G+Y+C   N LG A  +    VL+  PP+
Sbjct: 2578 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 2634

Query: 404  FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
                    E   +E   +V   L + C +   PPP + W K G+ +    + QV     L
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 2694

Query: 456  I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
            + ++P      G + C A+N         NV +
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 96/344 (27%), Positives = 141/344 (40%), Gaps = 50/344 (14%)

Query: 188  NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
            +G+LR+ +V+ G SG Y C AS+  GSA+H   L V  PP +   P+   V   + + L 
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140

Query: 248  CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG- 306
            C AE  P     SW +D +       LQ R      GS+   A +  DAG Y C  SN  
Sbjct: 1141 CVAEGNP-EPQLSWSKDGV------VLQGRG---PQGSVHFAAIRTSDAGRYRCEASNSA 1190

Query: 307  ----------LLHPPSASAYLTVLCMPGV------IRCPVRANPPLLFVSWTKDGKALQL 350
                      +L PP   A  T   +  V      + CP R  P    V+W K   +  L
Sbjct: 1191 GVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ-VTWRKGPSSEPL 1249

Query: 351  DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410
               PG +   EGSL +A  +    G+Y C   N +G+   S   ++++  PP+  E  ++
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPSIREDGRK 1307

Query: 411  EYFQEV-GRELLIPCSAQGDPPPVVSWTK-----------VGRG-------LQGQAQVDS 451
                 + G+ L + C A G P P + W K            G G       + G   +D 
Sbjct: 1308 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367

Query: 452  NSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495
              SL    + +   G + C A N         ++ VL T P V+
Sbjct: 1368 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL-TPPSVL 1410



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%)

Query: 13   VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
            V+    + +  P+++   G    + ++G  L  P  A   P+  I+WL+ G         
Sbjct: 1677 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 1727

Query: 71   GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
                 R   +  G     +G +L I+ + ++  G + C+          +    G+ V +
Sbjct: 1728 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 1775

Query: 131  TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
            +V+      E  P VLEV         +        C   V RG    P P +   W   
Sbjct: 1776 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 1830

Query: 174  GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
            G   G+  G     +    L+I +V+    G+YTC A++  G +     L VL PP I  
Sbjct: 1831 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 1890

Query: 232  PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
             P N  V  +  V+L C A   P     SWF+ +  V         V + VDG  LR+  
Sbjct: 1891 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 1945

Query: 291  TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
             Q  DAG Y CV SN         GL ++ P        L  P ++  PVR        P
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 2005

Query: 336  LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
               + W KDG  +     PG      G  L +A       G YSC   +++G      V 
Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 2065

Query: 395  RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
            +V +  PP+ +   +E     V  E + + C +   PPPV+SW K GR L+ +  V  ++
Sbjct: 2066 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 2121

Query: 454  SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
               L  + +      GH+ C A N         N+ V
Sbjct: 2122 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 131/490 (26%), Positives = 187/490 (38%), Gaps = 110/490 (22%)

Query: 29   VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
            V+   GE  VL C+    +G PP  VI W R G  +                    +   
Sbjct: 707  VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 742

Query: 89   KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
            +G+S   L+I   +  D G Y CR       + E   A+   + L V   PQ  E P  V
Sbjct: 743  EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 795

Query: 146  LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
              V+      L C A G P P VTW+       G  LG G+G    Q  +G L    V  
Sbjct: 796  T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 854

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
                 Y C+A +  G      +L+V G  PP I        V   Q VSL C   A    
Sbjct: 855  EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914

Query: 257  LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310
                W +D         L P  R  I  DGSL L     + AG Y+CV +N  G  H   
Sbjct: 915  PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 968

Query: 311  -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
                       P+A+ ++T   +P  + C V +  P   ++WTK+  AL   + P ++  
Sbjct: 969  ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 1026

Query: 360  TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
             EG+L+IA  +    G Y CT  N++G +       V   A   ++       ++E G  
Sbjct: 1027 KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYV-------WEEYG-- 1077

Query: 420  LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARV 479
             L+P                            + SL L  +     GH+EC+ASN     
Sbjct: 1078 -LLP----------------------------SGSLRLAQVQVGDSGHYECTASNP---A 1105

Query: 480  ATSTNVYVLG 489
             ++++ YVLG
Sbjct: 1106 GSASHRYVLG 1115



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
            R +LQ G SL I     +D G Y+C        + E++      V + V  S P FQ   
Sbjct: 4265 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 4314

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
            P  + V+  + V LRC A G P P + W   G+ L   +    + +G+L +  VE G +G
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374

Query: 203  VYTCQASSTEGSATHATQLLVLGPP 227
             Y C A +  GSAT    L+V G P
Sbjct: 4375 TYDCVAHNLLGSATARAFLVVRGEP 4399



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%)

Query: 93   LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
            LQI   + ED G Y C V   L + +           H+ V  PP   +  P     V E
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 2648

Query: 148  VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
            V+      +TL C +   P P + W   G+ +      QV  +   L+I+  +   SG Y
Sbjct: 2649 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 2708

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
             C A++  G       +L+  PP+       S                     +  +   
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768

Query: 245  SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
             L C   A P     +W++++  +         V +L  G  L++   + ++AG Y+C  
Sbjct: 2769 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 2823

Query: 304  SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
            SN            +L PP            +TV     V ++CP   N P+  +SW ++
Sbjct: 2824 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 2882

Query: 345  GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            G  L     P      +G ++ ++         Y C   N  G+A      RV  + PP 
Sbjct: 2883 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 2938

Query: 404  FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
                  E+    +   + +PC     P P V+W K  + L    +V       +L L   
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998

Query: 461  TKEAHGHWECSASNAVAR 478
                 G + C A NA  R
Sbjct: 2999 RLSDSGMYTCEALNAAGR 3016


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  125 bits (313), Expect = 3e-28
 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)

Query: 29   VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
            VVG A   +VL C +       P   I W R G +L      QF                
Sbjct: 2309 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2349

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
             ++G  LQ++ L   D G Y C            + A  + V   + +++ P  +  PPA
Sbjct: 2350 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2399

Query: 145  VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
            V  V   +   L C A G P P V+W+     L     + ++   G+LRI+ V    +G 
Sbjct: 2400 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458

Query: 204  YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
            Y C AS++ GS      L VL PP I   P N T+ A     L C A   P  L   W  
Sbjct: 2459 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2518

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
                 F +   Q   R+L   +L L A  P D+  + CV SN +          +H P  
Sbjct: 2519 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576

Query: 314  SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
             A     +   +  P V+ C      P   VSW+K G  L   +  G+     G+L I  
Sbjct: 2577 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2634

Query: 369  GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
                  G Y+C+  NS G A       V L    + + +P     + V   E+L+PC A 
Sbjct: 2635 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690

Query: 428  GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
            G P P ++W K G  +      QV     L +   + E  G++ C A N+       T +
Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750

Query: 486  YVLGTSPHVVTN 497
             V    P V+ N
Sbjct: 2751 VV--QVPPVIEN 2760



 Score =  118 bits (295), Expect = 4e-26
 Identities = 110/386 (28%), Positives = 162/386 (41%), Gaps = 37/386 (9%)

Query: 128  VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
            V LTV + P  +  P  V  V E E V L C A G P P +TW+  G ++  G     + 
Sbjct: 2658 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2716

Query: 188  NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
             G LRI       +G Y C A ++ GSA   T+L+V  PPVI     + +        L 
Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2776

Query: 248  CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
            C A   P  N+T  W +D   V   S  + +  I   G L +   +  DAG YTC   N 
Sbjct: 2777 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2831

Query: 307  LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
             +       +LT+L +P                  +RC  R +P    + WT + + +  
Sbjct: 2832 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2888

Query: 351  DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
                G S+   GS +   A+  ED+ G Y C   N +G      V+ V +K  P      
Sbjct: 2889 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 2942

Query: 409  KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
                 + VG  + + C  +GDP P + W K G  L+G        N SL +R   ++  G
Sbjct: 2943 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAG 3002

Query: 467  HWECSASNAVARVATSTNVYVLGTSP 492
             ++C A N +  VA    + VL ++P
Sbjct: 3003 RYQCLAENEMG-VAKKVVILVLQSAP 3027



 Score =  108 bits (271), Expect = 2e-23
 Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%)

Query: 28  SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
           +V G AG+S+ L CD    A   P+  I WL+   L+ + + +  Y   +    VG  RL
Sbjct: 27  NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82

Query: 88  -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
             +G SL    ++  D G Y CR         + DF      HL V +PP       A  
Sbjct: 83  LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 134

Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
           EV  L    V L+C   G P P V W    + +  G   +QVQ     LRI     G  G
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194

Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
            Y C A S  G      QL V  PP I    +   V   +D  V L C A   P  N+T 
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 253

Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308
            WF+D   +   +++   V       L+L   Q  DAG YTC  SN            + 
Sbjct: 254 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309

Query: 309 HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360
            PP+             V   P  + C  R +P P L  SW  +G  L + +       T
Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 365

Query: 361 EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
           +GS++ +    E + G YSC   +  G A       V +  P   +     +    VG+ 
Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 424

Query: 420 LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
           L +PC A G P P + W + GR    L G       ++L +  +  +  G + C A+N  
Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484

Query: 477 ARVATSTNVYVLG 489
                   V V G
Sbjct: 485 GTAGAEVEVSVHG 497



 Score =  108 bits (271), Expect = 2e-23
 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)

Query: 24   PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
            P VV  V  A E V+L C+    A   P   I W + G  +   +               
Sbjct: 2672 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2711

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
              ++  G  L+I     ED G Y C        I ++   +      L V  PP  +   
Sbjct: 2712 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2762

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
            P  L   E     L C ARGSP P++TW   G+ +   +G+  +Q +G L ++ +E   +
Sbjct: 2763 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2821

Query: 202  GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
            G YTC A +  G A     L +L  PV    P + ++     + L C A   P       
Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881

Query: 262  FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
              D      +S            +L+  A   +D+G Y C   N +    + S       
Sbjct: 2882 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 2935

Query: 315  --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
                    +YL V  + G I+  C VR +P +  + W KDG  L+        Q   GSL
Sbjct: 2936 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 2991

Query: 365  IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
             I     D  G Y C   N +G A    V  ++L++ P F   P++   +  G ++ + C
Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3048

Query: 425  SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
             A G+P P + W + G+ L+   ++ +  + SL L  +     G ++C A N +      
Sbjct: 3049 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3108

Query: 483  TNVYVLG 489
              + V G
Sbjct: 3109 AFLVVRG 3115



 Score =  108 bits (269), Expect = 4e-23
 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)

Query: 87   LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
            L +G  LQI+  +V D G Y C    +     +D        ++ +  PP FQ       
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1459

Query: 140  ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
                     E    V E +E+    P  L C     P P +TW    + L  G     +Q
Sbjct: 1460 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1519

Query: 188  NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
             G  L+I  V   ++G Y+C+AS+  G      +LLVL PPVI+       +  TVNAS 
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1579

Query: 243  DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
             VSL C A   P   T SW Q+ +         PR+++L DG  L++   +  DA  Y C
Sbjct: 1580 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634

Query: 302  VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
            V  N            +  PP  +      +T +    V + C V A+P    V+W KD 
Sbjct: 1635 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1693

Query: 346  KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
            +AL L +      GT  +L +        G Y+C   N+ G      + ++ +  PPAF 
Sbjct: 1694 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1750

Query: 406  ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
            + P+   +     VG + ++ C     P P V+W K G+ L   Q    +     L ++ 
Sbjct: 1751 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1810

Query: 460  LTKEAHGHWECSASNAVARVATSTNVYV 487
                  G + C  SN       +  + V
Sbjct: 1811 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1838



 Score =  106 bits (264), Expect = 1e-22
 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)

Query: 34   GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
            G+ V L C+     G+PP  V  WL+ G            SP +  D    +R    G S
Sbjct: 1950 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 1992

Query: 93   LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
            L ++GLR  D G Y C       H P  + A    V++ V  PP  ++       L  + 
Sbjct: 1993 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2045

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
             E VT+ C  RGSP  HV+W   G  L   Q  +   +G TLRI +V+   +G++TC A+
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105

Query: 210  STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
            S  G A     L V  PPV+  V    +  V     V L C A   P  L  SW +D   
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2164

Query: 268  VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
            +   S  Q         SL+L A    D+G Y+CV  +            ++ PP    S
Sbjct: 2165 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217

Query: 315  AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
               T L +    P  + C  +  P    ++W KDG+A  L +    S+ T       L  
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2269

Query: 371  EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
             DA G Y+C   +  G    S   RV ++APP  +  P+   F  VG    +L++ CS +
Sbjct: 2270 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2324

Query: 428  GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
             +P P ++W + G  LQ  A     +    L L+ L+    G + C+A NA    + +  
Sbjct: 2325 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384

Query: 485  VYVLGTSPHVVTNVSVVALPKGANVS 510
            V +     H V  +   + P   NVS
Sbjct: 2385 VEI-----HTVPTIR--SGPPAVNVS 2403



 Score =  103 bits (257), Expect = 1e-21
 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)

Query: 26   VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
            V  V   A  +V L C    PA   P+  I WL+ G  LP        SPR+        
Sbjct: 1570 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1612

Query: 86   RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
             L+ G  LQ+    V D   Y C        + E+   +   +  L V  PP+      E
Sbjct: 1613 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663

Query: 141  TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
               A+L       V+L C     P P VTW    + L  G+ +V +  GT  L++ R   
Sbjct: 1664 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1718

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
              SG+YTC+A +  G      QL VL PP     P+       V       L+C  +A P
Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778

Query: 255  ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
               T +W++D   +     L  R + L  G  L +   Q  D G Y+C  SN        
Sbjct: 1779 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1833

Query: 306  --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
                         P       V   P V+ C V +  P   V+W KD   ++     G  
Sbjct: 1834 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1892

Query: 357  SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
            S+G  G L ++       G Y+C   N+   A    V  VL+ AP         E+    
Sbjct: 1893 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 1949

Query: 417  GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
            G+E+ + C A G PPP V+W K G  L GQ             SL+L+ L     G + C
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008

Query: 471  SASNAVARVATSTNVYVL 488
             A N     A    V VL
Sbjct: 2009 VAHNPAGEDARLHTVNVL 2026



 Score =  102 bits (254), Expect = 2e-21
 Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 59/434 (13%)

Query: 91   ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
            A LQ++   V D G Y C       H  E  +    WV       P F       L V+E
Sbjct: 842  ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 894

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
              P  L C  RG P P ++W+  G+ L G+G G   V      L + + +    G YTC+
Sbjct: 895  GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954

Query: 208  ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
             S+  G+++   QL V  PP I  P +  T V+  QD   +L C+A   P   T +W +D
Sbjct: 955  CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1013

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
               V     LQ + +     SL +   Q    G Y+CV  N            +L PP  
Sbjct: 1014 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070

Query: 314  SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
               L         L  P  + C     PP   + W +  + +     PG     E + ++
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1120

Query: 367  ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
            A G         E   G YSC   N  G A  +    VL+  PP+      EE  + + G
Sbjct: 1121 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1178

Query: 418  RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
            +   + C+  G P P ++W K GR L +G A   S   ++L+ L     + GH+ C A+N
Sbjct: 1179 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238

Query: 475  AVARVATSTNVYVL 488
            AV        + VL
Sbjct: 1239 AVGEKTKHFQLSVL 1252



 Score =  102 bits (253), Expect = 3e-21
 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
            G  L +   ++  +G Y C    +  +  +D       + L V+ PPQ      PP  + 
Sbjct: 935  GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 987

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
            V +    TL C A G P P VTW+  G+ +G   G Q+Q Q  +L + R +   +G Y+C
Sbjct: 988  VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047

Query: 207  QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
             A +  G A    +L VL PP ++    P  N T      ++L C A   P      WF+
Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1106

Query: 264  DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
                V   S  +    +     L++  TQ  D+G Y+C+ SN            +L PPS
Sbjct: 1107 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1163

Query: 313  -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
                     + VL      + C V  +P P L  +W KDG+ L   +        +G L+
Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1219

Query: 366  IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
              L  N  + G YSC   N++G         VLL AP       +   EE    V   + 
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1278

Query: 422  IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
            + C A   P P ++W K G   +    +        L +    KE  G + C  +N +  
Sbjct: 1279 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1338

Query: 479  VATSTNVYVL 488
               + +V VL
Sbjct: 1339 AVKNYHVEVL 1348



 Score =  100 bits (249), Expect = 8e-21
 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)

Query: 88  QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
           + G  L+I G  V D+G Y+C V F        DF       L V++PP  +       +
Sbjct: 178 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 230

Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
            V E   V L C ARG P P++TW   G  L      V  + G  L++ R +   +GVYT
Sbjct: 231 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 290

Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
           C+AS+  G+A  AT+L V  PP I      P      A + V+L C A  +P+  T SW 
Sbjct: 291 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 349

Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
            + + V   +      R+  DGS LRL +     +G Y+CV S+                
Sbjct: 350 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405

Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
             LL         T++  P  + C   +  P+  + W ++G+ A +L      SQGT  +
Sbjct: 406 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 462

Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
           L I     D  G ++C   N  GTAG      V  +  P  +E P  +Y          P
Sbjct: 463 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 522

Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
            +          A   PP V  W   G  L G+      +  +  PL  E       G +
Sbjct: 523 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 581

Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
            C+A+N          + VL   P++       A+ + A+V+ E    G      S W+ 
Sbjct: 582 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 638

Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
               +  +    W+ + V V    L +   Q      +  +A N  GS      + ++ P
Sbjct: 639 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 694

Query: 588 EGLPTTPAAPG 598
             +   P+ PG
Sbjct: 695 PRITLPPSLPG 705



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)

Query: 16   QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
            Q A  R  P  VSVV        L C+     G+PP   + W R G   P+  + GL   
Sbjct: 975  QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1023

Query: 76   RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
                      +LQ +G SL +E  +    G Y C    L                L+V  
Sbjct: 1024 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1066

Query: 135  PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
            PP+      P   +      P+TL C A G P P + W    + +  G+    +  G  L
Sbjct: 1067 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1126

Query: 192  RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
            ++ + +   SG+Y+C AS+  G A     + VL PP I        +     Q   L C+
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186

Query: 250  AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
               +P     +WF+D       +  HIS          DG L ++L      AG Y+C+ 
Sbjct: 1187 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1236

Query: 304  SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
            +N +    +    L+VL  P ++            V  N P+  +           +W K
Sbjct: 1237 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295

Query: 344  DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            DG   +  +      GT G  I+    EDA G+Y+C   N LG A  +    VL+  PP+
Sbjct: 1296 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1352

Query: 404  F------IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
                    E   +E   +V   L + C +   PPP + W K G+ +    + QV     L
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1412

Query: 456  I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
            + ++P      G + C A+N         NV +
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)

Query: 90   GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
            G  L+IE  ++ D G Y C            + A  + +   L VN PP+    P     
Sbjct: 656  GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 706

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
            V    PV L C A G+P P + W   G  +   G   +QV  G   L +       SG Y
Sbjct: 707  VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
            +C A S  G       L V  PP I+    N +V A++ V+L C + A P  +  SW++D
Sbjct: 767  SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 825

Query: 265  NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309
                     L+PR  + +     LL        DAG YTC   N   H            
Sbjct: 826  G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 879

Query: 310  ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
               P   S  LTV    P  + C  R   P   +SW KDG+ L     PG   G +    
Sbjct: 880  PVFPLRESHTLTVREGHPTRLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 933

Query: 363  -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
               ++ LG       G Y+C   N +G +       V +    A    P  +        
Sbjct: 934  VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 993

Query: 420  LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
              + C+A G PPP V+W + G+  G +   Q+ +    +     + AH G + C A N  
Sbjct: 994  ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1053

Query: 477  ARVATSTNVYVL 488
             R      + VL
Sbjct: 1054 GRAERKFELSVL 1065



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%)

Query: 13  VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
           V+    + +  P+++   G    + ++G  L  P  A   P+  I+WL+ G         
Sbjct: 395 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 445

Query: 71  GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
                R   +  G     +G +L I+ + ++  G + C+          +    G+ V +
Sbjct: 446 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 493

Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
           +V+      E  P VLEV         +        C   V RG    P P +   W   
Sbjct: 494 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 548

Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
           G   G+  G     +    L+I +V+    G+YTC A++  G +     L VL PP I  
Sbjct: 549 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 608

Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
            P N  V  +  V+L C A   P     SWF+ +  V         V + VDG  LR+  
Sbjct: 609 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 663

Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
            Q  DAG Y CV SN         GL ++ P        L  P ++  PVR        P
Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 723

Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
              + W KDG  +     PG      G  L +A       G YSC   +++G      V 
Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 783

Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
           +V +  PP+ +   +E     V  E + + C +   PPPV+SW K GR L+ +  V  ++
Sbjct: 784 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 839

Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
              L  + +      GH+ C A N         N+ V
Sbjct: 840 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)

Query: 84   RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
            R +LQ G SL I     +D G Y+C        + E++      V + V  S P FQ   
Sbjct: 2983 RHQLQNG-SLTIRRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3032

Query: 143  PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
            P  + V+  + V LRC A G P P + W   G+ L   +    + +G+L +  VE G +G
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092

Query: 203  VYTCQASSTEGSATHATQLLVLGPP 227
             Y C A +  GSAT    L+V G P
Sbjct: 3093 TYDCVAHNLLGSATARAFLVVRGEP 3117



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 97/438 (22%), Positives = 159/438 (36%), Gaps = 70/438 (15%)

Query: 93   LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP-AVLEVQE 150
            LQI   + ED G Y C V   L + +           H+ V  PP   +  P A + V+E
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLAEVGVKE 1366

Query: 151  LEP-----VTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
            ++      +TL C +   P P + W   G+ +      QV  +   L+I+  +   SG Y
Sbjct: 1367 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1426

Query: 205  TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
             C A++  G       +L+  PP+       S                     +  +   
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486

Query: 245  SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
             L C   A P     +W++++  +         V +L  G  L++   + ++AG Y+C  
Sbjct: 1487 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1541

Query: 304  SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
            SN            +L PP            +TV     V ++CP   N P+  +SW ++
Sbjct: 1542 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1600

Query: 345  GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
            G  L     P      +G ++ ++         Y C   N  G+A      RV  + PP 
Sbjct: 1601 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1656

Query: 404  FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
                  E+    +   + +PC     P P V+W K  + L    +V       +L L   
Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716

Query: 461  TKEAHGHWECSASNAVAR 478
                 G + C A NA  R
Sbjct: 1717 RLSDSGMYTCEALNAAGR 1734


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  124 bits (311), Expect = 5e-28
 Identities = 141/499 (28%), Positives = 204/499 (40%), Gaps = 83/499 (16%)

Query: 29   VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
            V+   GE  VL C+    +G PP  VI W R G  +                    +   
Sbjct: 590  VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 625

Query: 89   KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
            +G+S   L+I   +  D G Y CR       + E   A+   + L V   PQ  E P  V
Sbjct: 626  EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 678

Query: 146  LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
              V+      L C A G P P VTW+       G  LG G+G    Q  +G L    V  
Sbjct: 679  T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737

Query: 199  GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
                 Y C+A +  G      +L+V G  PP I        V   Q VSL C   A    
Sbjct: 738  EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797

Query: 257  LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310
                W +D         L P  R  I  DGSL L     + AG Y+CV +N  G  H   
Sbjct: 798  PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851

Query: 311  -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
                       P+A+ ++T   +P  + C V +  P   ++WTK+  AL   + P ++  
Sbjct: 852  ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 909

Query: 360  TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE------EYF 413
             EG+L+IA  +    G Y CT  N++G +  S   R+ +   P              +  
Sbjct: 910  KEGTLLIAQPSAQDAGAYVCTATNTVGFS--SQEMRLSVNTKPRIHMNGSRNANVPLQVT 967

Query: 414  QEVGRELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWEC 470
             + G E+ + C A+G PPP+V+WTK  R    +  +  +  + SL L  +     GH+EC
Sbjct: 968  AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027

Query: 471  SASNAVARVATSTNVYVLG 489
            +ASN      ++++ YVLG
Sbjct: 1028 TASNP---AGSASHRYVLG 1043



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%)

Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
           +P+ + C    S LP      RG+  LG+ +   +  N +  I R  +   G Y C A S
Sbjct: 325 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383

Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
             G+     Q++V  PP  +VP  N TV+  +   L+C    EA P NLT  W +D    
Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 436

Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324
               R+ P    RV  L D SL +    P D G Y CV SN       AS +L V   P 
Sbjct: 437 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 492

Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367
           V                + C   +  P   +SW+++ +ALQ D         +G+LII  
Sbjct: 493 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 549

Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427
           +  EDA G YSC   N +GT      T  L    P  +          VG E ++ C A 
Sbjct: 550 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605

Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
           G PPP V W + G  +    +  S+  L +    +   G + C A N +   +    + V
Sbjct: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665

Query: 488 LGTSPHV 494
            G +P +
Sbjct: 666 -GHAPQL 671



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%)

Query: 14  ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
           +S+   GR K ++V            +V    GE+ VL C +L   G  P + + W+R  
Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 435

Query: 62  FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
                         R+ P   GRV      SL+I G+   D G Y+C             
Sbjct: 436 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 473

Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
            ANG   + V L V   PQ      +    Q +E V + C A G P PH++W    + L 
Sbjct: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 531

Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
           Q   ++ V   GTL I+ V    +G Y+CQA++  G+      L    PP +        
Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591

Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
           V   ++  L C A   P      W++  + +     L P       G LR+ A Q  DAG
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 644

Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341
            YTC   N  L   SA   L V                L    ++ C     PP   V+W
Sbjct: 645 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 702

Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
            + DG+ L L    G      Q   G L       +    Y C   N  G         V
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762

Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453
              APP            E G+ + +PC    G P P   W K GR L    +  + ++ 
Sbjct: 763 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821

Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502
           SL L    +E  G + C A+N          + V        T+ H +TN  V A
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 876



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 36/105 (34%), Positives = 54/105 (51%), Gaps = 7/105 (6%)

Query: 128  VHLTVNSPPQFQ------ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
            + L+VN+ P+           P  +  +  E VTL C A+GSP P VTW    + +    
Sbjct: 942  MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001

Query: 182  GQVQV-QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG 225
             +  +  +G+LR+ +V+ G SG Y C AS+  GSA+H   L V G
Sbjct: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
            sapiens]
          Length = 1386

 Score =  122 bits (306), Expect = 2e-27
 Identities = 268/1142 (23%), Positives = 402/1142 (35%), Gaps = 203/1142 (17%)

Query: 28   SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
            +VV   GE  VL C  +PP G P   V  W + G  L               +  GR+ +
Sbjct: 174  NVVVAVGEPAVLEC--VPPRGHPEPSV-SWRKDGARLK--------------EEEGRITI 216

Query: 88   QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLE 147
            + G  +    L+  D G Y C    +            +   + V   P F   P   + 
Sbjct: 217  RGGKLMMSHTLK-SDAGMYVCVASNMAGE------RESAAAEVMVLERPSFLRRPVNQVV 269

Query: 148  VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207
            + +  PVT  C  +G P P + W+    +L  G+ +++  + +L I  V     G YTC 
Sbjct: 270  LADA-PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDH-SLWIGHVSAEDEGTYTCV 327

Query: 208  ASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
            A ++ G A  +  L V  PP +V  P++      + V+  C  +  P    + W ++   
Sbjct: 328  AENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF-WQKEGSQ 386

Query: 268  V--FHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC--------VPSNGLLHPPSAS- 314
            V  F    LQP  R  V   G L + A Q  DAG Y C        + +  LL    AS 
Sbjct: 387  VLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASL 446

Query: 315  -----------AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 362
                       A  T++    V + C V  NP    V W KDG+ LQ D    +     G
Sbjct: 447  DGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPS-VRWKKDGQWLQGDDLQ-FKTMANG 504

Query: 363  SLIIALGNEDALGEYSCTPYNSLGTA------------GPSPVTRVLLKAPPAFIERPKE 410
            +L IA   E  +G YSC   +S G A            G SP       +PP     P +
Sbjct: 505  TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG---APSQ 561

Query: 411  EYFQEVGRELLI----PCSAQG-----------DPPPVVSWTKVGRGLQGQAQVDSNSSL 455
                E+ +  +     P    G            P    +W  V  G+Q +    S    
Sbjct: 562  PVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSG--- 618

Query: 456  ILRPLT-----KEAHGHWECSASNAVARVATSTNVYVLGTSPH----------------- 493
             L+P T       A G W  S  + V     S  V    +SP                  
Sbjct: 619  -LQPNTIYLFLVRAVGAWGLSEPSPV-----SEPVRTQDSSPSRPVEDPWRGQQGLAEVA 672

Query: 494  VVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHL 553
            V     +V  P+   VSW        +Q F V +      P+      + L  P   + +
Sbjct: 673  VRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAG--PEGGSWTMLDLQSPSQQSTV 730

Query: 554  LVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612
            L  GL P TQ Q  V AQ + G G  S  +  S PE  P+                 PP+
Sbjct: 731  L-RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS----------------GPPQ 773

Query: 613  GLVAVRTPRG---VLLHWDPPELVPKRLDGYVLEGR---QGSQGWEVLDPAVAGTETELL 666
            G+       G   + + W+PP  +P + +G + E +    G++    L+ + AG     +
Sbjct: 774  GVAVALGGDGNSSITVSWEPP--LPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAM 831

Query: 667  VPGLIKDVLYEFRLVAFAGSFVSDPSNTANVS-------TSGLEVYPS-RTQLPGLLPQP 718
            + GL+  +LY   + A   + V  PS    V          GLEV      +L  +L +P
Sbjct: 832  LRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREP 891

Query: 719  VLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALG 778
                  G  C    A+L+ + A          RR++++        F+ T   + P + G
Sbjct: 892  AFLAGSGAAC---GALLLGLCAALYW------RRKQRKELSHYTASFAYTPAVSFPHSEG 942

Query: 779  SGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFV 838
                 S   + L  +P   L  S  W  P+ +PS   +P  S    P  P    PD R+ 
Sbjct: 943  LSGASSRPPMGLGPAPYSWLADS--WPHPSRSPSAQ-EPRGS--CCPSNP---DPDDRYY 994

Query: 839  MGPTVAAPQERSGREQAEPR--------TPAQRLARSFDCS-SSSPSG--------APQP 881
                ++    ++ R  A P          PA    ++F       PSG        AP  
Sbjct: 995  NEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPE 1054

Query: 882  LCIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930
                D             PV  P    P  LP P P  + LS     E  ++G   P EE
Sbjct: 1055 WSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCE-LSCLEGPEEELEGSSEP-EE 1112

Query: 931  PSPAAPPDYMDTRRCPTSSFLRSP---ETPPVSPRESLPGAVVGAGATAEPPYTALADWT 987
              P  P     T    +   L +P   ETP  +P            +  +PP        
Sbjct: 1113 WCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPH 1172

Query: 988  LRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPE 1047
            L +  +P  +P  P   L+      G          A  A   +LSP+P  +++ ++   
Sbjct: 1173 LHQ--MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGR 1230

Query: 1048 RW 1049
             W
Sbjct: 1231 TW 1232



 Score =  118 bits (296), Expect = 3e-26
 Identities = 153/596 (25%), Positives = 240/596 (40%), Gaps = 90/596 (15%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F+++P  V+ V   EP  L CV  RG P P V+W+  G  L + +G++ ++ G L +   
Sbjct: 168 FRQSPGNVV-VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226

Query: 197 ERGSSGVYTCQASSTEGS-ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G+Y C AS+  G   + A +++VL  P  +  P N  V A   V+  C  +  P 
Sbjct: 227 LKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
                W +++  +        R  I  D SL +     +D G YTCV  N  +    AS 
Sbjct: 287 P-RLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENS-VGRAEASG 339

Query: 316 YLTV-------------LCMPG---VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---- 355
            L+V             +  PG     +C  + NPP   + W K+G  + L  FP     
Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPA-IFWQKEGSQVLL--FPSQSLQ 396

Query: 356 ----WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV----LLKAPPAFIER 407
               +S    G L I        G Y C   +  G+     +  +    L   PP  ++ 
Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG 456

Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQG---QAQVDSNSSLILRPLTKEA 464
           P  +    +G  + +PC   G+P P V W K G+ LQG   Q +  +N +L +  + +  
Sbjct: 457 PANQTL-VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMD 515

Query: 465 HGHWECSASNAVARVATSTNVYV---LGTSPHVVTNVS----------VVALPKGA-NVS 510
            G + C A ++      S  + +    G SP   T  S          V  + K +  ++
Sbjct: 516 MGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575

Query: 511 WEPGFDGGYLQRFSV--WYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
           W+P    G      V   ++P A       + W ++A  V      V GLQP+T Y F V
Sbjct: 576 WKPNPQTGAAVTSYVIEAFSPAA------GNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629

Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL--VAVRT------- 619
            A    G    S +     E + T  ++P  P   +  P    +GL  VAVR        
Sbjct: 630 RAVGAWGLSEPSPV----SEPVRTQDSSPSRP---VEDPWRGQQGLAEVAVRLQEPIVLG 682

Query: 620 PRGVLLHW---DPPELVPKRLDGYVLEGRQGSQGWEVLD---PAVAGTETELLVPG 669
           PR + + W    P +LV      + + G +G   W +LD   P+   T    L PG
Sbjct: 683 PRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGG-SWTMLDLQSPSQQSTVLRGLPPG 737



 Score =  117 bits (292), Expect = 8e-26
 Identities = 156/621 (25%), Positives = 244/621 (39%), Gaps = 72/621 (11%)

Query: 118 PEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDL 177
           P D   NGS V    ++ P+  E PP +L V   EP TL C A G P P++ W   G  +
Sbjct: 47  PGDPSLNGSRVG-PEDAMPRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYKNGARV 104

Query: 178 GQGQ-----GQVQVQNGTLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLG 225
              +      ++ + +G L   R+  G       GVYTC A +  G+A   +A+  + + 
Sbjct: 105 ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL 164

Query: 226 PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS 285
                  P N  V   +   L C         + SW +D      +   + R+ I   G 
Sbjct: 165 RDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA---RLKEEEGRITIR-GGK 220

Query: 286 LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR----ANPPLLF--- 338
           L +  T   DAG Y CV SN      SA+A + VL  P  +R PV     A+ P+ F   
Sbjct: 221 LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCE 280

Query: 339 --------VSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390
                   + W K+   L   ++      ++ SL I   + +  G Y+C   NS+G A  
Sbjct: 281 VKGDPPPRLRWRKEDGELPTGRY---EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEA 337

Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG--------RG 442
           S    V    PP  + +P+++     G  +   C  +G+PPP + W K G        + 
Sbjct: 338 SGSLSV--HVPPQLVTQPQDQ-MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQS 394

Query: 443 LQ--GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-----PHVV 495
           LQ  G+  V     L +  + +   G++ C A +    +     + + G S     P ++
Sbjct: 395 LQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL 454

Query: 496 TNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLV 555
              +   L  G++V W P    G  Q    W     K    +  D +          L +
Sbjct: 455 QGPANQTLVLGSSV-WLPCRVTGNPQPSVRW----KKDGQWLQGDDLQFKTMANGT-LYI 508

Query: 556 PGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE-IPPPLSPPRGL 614
             +Q      +S +A++  G   +S   L   E    +P     PPTE   PP +P + +
Sbjct: 509 ANVQEMDMGFYSCVAKSSTGEATWSG-WLKMREDWGVSPD----PPTEPSSPPGAPSQPV 563

Query: 615 VAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQG--WE-VLDPAVAGTETELLVPGLI 671
           V   T   + L W P       +  YV+E    + G  W  V D     T T   V GL 
Sbjct: 564 VTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHT---VSGLQ 620

Query: 672 KDVLYEFRLVAFAGSFVSDPS 692
            + +Y F + A     +S+PS
Sbjct: 621 PNTIYLFLVRAVGAWGLSEPS 641


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  120 bits (300), Expect = 1e-26
 Identities = 157/603 (26%), Positives = 239/603 (39%), Gaps = 102/603 (16%)

Query: 154 VTLRCVARGSPLP--HVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA--- 208
           VTL CVA   PL   H+ WK  G  L  G   +   N  L I       +G Y C+A   
Sbjct: 233 VTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAVLR 289

Query: 209 SSTEGSATHATQLLVLGPPVIVVPP-KNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
           SS+  S      L VL PP  V  P ++ T    + V + C A+  P   + +W++D   
Sbjct: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP-SITWYKDAA- 347

Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCM-PGVI 326
           V  + +L  R R   DG L++    PDD G + C   N        S YL V  + P + 
Sbjct: 348 VVEVEKLT-RFRQRNDGGLQISGLVPDDTGMFQCFARNAA-GEVQTSTYLAVTSIAPNIT 405

Query: 327 RCPV---------------RANPPLLFVSWTKDGKALQLD--KFPGWSQGTEGSLIIALG 369
           R P+                +  P   ++W K  + L     + P ++    GSL+I+  
Sbjct: 406 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465

Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429
           +    G Y+C   NS G    S    V  +     I +P ++     G +  + C    D
Sbjct: 466 HISDAGTYTCLATNSRGVDEASADLVVWARTR---ITKPPQDQSVIKGTQASMVCGVTHD 522

Query: 430 PPPVVS--WTKVGRGLQGQA----QVDSNSSLILRPLTKEAHGHWECSASNAVARVATST 483
           P   +   W K G  L  ++    ++D N SL +        G + C   +A    + S 
Sbjct: 523 PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582

Query: 484 NVYV--LGTSP-HVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540
           ++ V  L  +P H V  +S V   +  N++W   FDG          +PL +    M  +
Sbjct: 583 HLRVRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGN---------SPLIRYILEMSEN 632

Query: 541 ---WVSLAVPVG--AAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV--LSAPEGLPTT 593
              W  L   V   A  + V GL P   YQF + A N +G G FS+    +S PE     
Sbjct: 633 NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE----- 687

Query: 594 PAAPGLPPTEIPPPLSPPRGLVAV-RTPRGVLLHWDPPELVPKR--LDGYVLEG-----R 645
                       PP +PP+ ++A  RT + +++ W PP    +   L GY++        
Sbjct: 688 -----------EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP 736

Query: 646 QGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVY 705
            G Q   + D  V      LL+  LI    YE  + A+              +++GL VY
Sbjct: 737 VGYQFKNITDADV----NNLLLEDLIIWTNYEIEVAAY--------------NSAGLGVY 778

Query: 706 PSR 708
            S+
Sbjct: 779 SSK 781



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 129/541 (23%), Positives = 202/541 (37%), Gaps = 72/541 (13%)

Query: 102 DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVAR 161
           D G+YEC        +P      G++  L+V  PPQF + P   +  +  + V + C A+
Sbjct: 278 DAGYYECEAVLRSSSVPS--VVRGAY--LSVLEPPQFVKEPERHITAEMEKVVDIPCQAK 333

Query: 162 GSPLPHVTWKLRGKDLGQGQGQV-----QVQNGTLRIRRVERGSSGVYTCQASSTEGSAT 216
           G P P +TW    KD    + +      Q  +G L+I  +    +G++ C A +  G   
Sbjct: 334 GVPPPSITWY---KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390

Query: 217 HATQLLVLG-PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQ 275
            +T L V    P I   P +STV     V LAC     P     +W +    +   S   
Sbjct: 391 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITWQKGERILASGSVQL 449

Query: 276 PRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIR-------- 327
           PR   L  GSL +  T   DAG YTC+ +N       ASA L V     + +        
Sbjct: 450 PRFTPLESGSLLISPTHISDAGTYTCLATNS-RGVDEASADLVVWARTRITKPPQDQSVI 508

Query: 328 --------CPVRANPPL-LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYS 378
                   C V  +P + +   W KDG  L  +  P       GSL I+      +G Y+
Sbjct: 509 KGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYT 568

Query: 379 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA--QGDPPPV--- 433
           C   ++ G    S   RV  +  P   E P         R + +  +    G+ P +   
Sbjct: 569 CRVISAGGNDSRSAHLRV--RQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI 626

Query: 434 -------VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR--VATSTN 484
                    WT +   +  +A     +S+ ++ L       +   A N V +   +  T 
Sbjct: 627 LEMSENNAPWTVLLASVDPKA-----TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681

Query: 485 VYVLGTSPHVVTNVSVVA---LPKGANVSWEP-------GFDGGYLQRFSVWYTPLAKRP 534
              L   P      +V+A     +   + W+P       G   GY+ R+ +   P+  + 
Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741

Query: 535 DRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLS-APEGLPTT 593
             +              +LL+  L   T Y+  V A N  G G +S  V     +G+PT 
Sbjct: 742 KNI--------TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793

Query: 594 P 594
           P
Sbjct: 794 P 794



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 131/559 (23%), Positives = 207/559 (37%), Gaps = 72/559 (12%)

Query: 164 PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLV 223
           P P VTW   G+ +            TL I       +G Y  QA + +      +Q + 
Sbjct: 141 PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 200

Query: 224 L------GP-----PVIVVPPKNSTVNA-SQDVSLACHAEAYP-ANLTYSWFQDNINVFH 270
           L      GP     P I++PPKN++V A + +V+L C A A P   L   W +D + +  
Sbjct: 201 LTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL-- 258

Query: 271 ISRLQPRVRILVDGSLRLLATQP--DDAGCYTCVPSNGLLHPPSA--SAYLTVLCMPGVI 326
                     + D + RL    P   DAG Y C         PS    AYL+VL  P  +
Sbjct: 259 -------SGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311

Query: 327 R-----------------CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 369
           +                 C  +  PP   ++W KD   ++++K   + Q  +G L I+  
Sbjct: 312 KEPERHITAEMEKVVDIPCQAKGVPP-PSITWYKDAAVVEVEKLTRFRQRNDGGLQISGL 370

Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429
             D  G + C   N+ G    S    V   AP   I R   +     G  +++ C   G 
Sbjct: 371 VPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMSVVLACETSGA 428

Query: 430 PPPVVSWTKVGRGL-QGQAQVD-----SNSSLILRPLTKEAHGHWECSASNAVARVATST 483
           P P ++W K  R L  G  Q+       + SL++ P      G + C A+N+      S 
Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488

Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVS 543
           ++ V+     +       ++ KG   S   G          V + P       + + W  
Sbjct: 489 DL-VVWARTRITKPPQDQSVIKGTQASMVCG----------VTHDPRV----TIRYIWEK 533

Query: 544 LAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE 603
               +G        L  +     S      +G+  ++  V+SA         +  L   +
Sbjct: 534 DGATLGTESHPRIRLDRNGSLHISQTWSGDIGT--YTCRVISAG---GNDSRSAHLRVRQ 588

Query: 604 IPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTET 663
           +P     P   ++    R + L W  P      L  Y+LE  + +  W VL  +V    T
Sbjct: 589 LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT 648

Query: 664 ELLVPGLIKDVLYEFRLVA 682
            + V GL+    Y+FRL A
Sbjct: 649 SVTVKGLVPARSYQFRLCA 667



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 75/277 (27%), Positives = 119/277 (42%), Gaps = 21/277 (7%)

Query: 77  IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
           ++ + + R R +    LQI GL  +D G ++C   F      E   +     +L V S  
Sbjct: 349 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC---FARNAAGEVQTS----TYLAVTSIA 401

Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQV----QVQNGTLR 192
                 P    V +   V L C   G+P P +TW+   + L  G  Q+     +++G+L 
Sbjct: 402 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461

Query: 193 IRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEA 252
           I       +G YTC A+++ G    +  L+V     I  PP++ +V      S+ C    
Sbjct: 462 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521

Query: 253 YP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHP 310
            P   + Y W +D   +   +   PR+R+  +GSL +  T   D G YTC V S G    
Sbjct: 522 DPRVTIRYIWEKDGATLG--TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG--GN 577

Query: 311 PSASAYLTVLCMPGVIRCPVRANPPL----LFVSWTK 343
            S SA+L V  +P     PV     +    + ++WTK
Sbjct: 578 DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 16/122 (13%)

Query: 509  VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
            +SWEPG DG    R+   YT   +          S +V   A+  +V  L+P T Y+F V
Sbjct: 1420 LSWEPGSDGLSPVRY---YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRV 1476

Query: 569  LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
             A N +G   FSE      E L T  AAP   PT +          V   T   VL+ W 
Sbjct: 1477 KATNDIGDSEFSE----ESESLTTLQAAPDEAPTILS---------VTPHTTTSVLIRWQ 1523

Query: 629  PP 630
            PP
Sbjct: 1524 PP 1525



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 41/200 (20%)

Query: 508  NVSWE-PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH-----LLVPGLQPH 561
            NVSWE P F  G L+ + + Y P +        D VS  V V         L V  L   
Sbjct: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPV------DGVSKIVTVDVKGNSPLWLKVKDLAEG 1794

Query: 562  TQYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
              Y+F + A+           V + P EG P  P  P                 + VR  
Sbjct: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVP-----------------IIVRYS 1837

Query: 621  RGVLLHWDPPELVPKRLDGYVLEGRQGSQG-WEVL---DPAVAGTET---ELLVPGLIKD 673
              + +HW   +     +  YV+E R   +G W++L    P    + T   ++L PG    
Sbjct: 1838 SAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPG---- 1893

Query: 674  VLYEFRLVAFAGSFVSDPSN 693
            V Y+FR++A        PS+
Sbjct: 1894 VSYDFRVIAVNDYGFGTPSS 1913



 Score = 37.7 bits (86), Expect = 0.064
 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 21/131 (16%)

Query: 557  GLQPHTQYQFSVLAQNKLGSGPFSE--IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614
            GL+P + Y F + AQ + G G  +E  +V +     P  P+ P +   ++          
Sbjct: 1364 GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDV---------- 1413

Query: 615  VAVRTPRGVLLHWDPPE--LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLI 671
                  R VLL W+P    L P R   Y ++ R+   G W +   +V+   +  +V  L 
Sbjct: 1414 ----RARSVLLSWEPGSDGLSPVRY--YTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467

Query: 672  KDVLYEFRLVA 682
                Y+FR+ A
Sbjct: 1468 PFTSYKFRVKA 1478



 Score = 34.7 bits (78), Expect = 0.54
 Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 17/142 (11%)

Query: 555  VPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614
            +  L+  T+Y+  V A N +GSGP+S+ V+       T  + P   PT +          
Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR-----TRESVPSSGPTNVS--------- 1207

Query: 615  VAVRTPRGVLLHW-DPPELVPKRLD-GYVLEGRQGSQGWEVLDPAVAGTET-ELLVPGLI 671
                T   +L+ W + PE     L  GY +  ++     +     V G  +    + GL 
Sbjct: 1208 ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 1267

Query: 672  KDVLYEFRLVAFAGSFVSDPSN 693
            K VLYE +++AF       PS+
Sbjct: 1268 KYVLYEVQVLAFTRIGDGSPSH 1289



 Score = 34.3 bits (77), Expect = 0.71
 Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 20/146 (13%)

Query: 492  PHVVTNVSVVAL-PKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWV---SLAVP 547
            P   TN+ +  + P+   + + PG+DG      S W             +W+    L+  
Sbjct: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGK--TSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050

Query: 548  VGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPP 607
              A  + VP L P T Y F +   N +G+ P            P+ P+   +   + PP 
Sbjct: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSP------------PSQPSRK-IQTLQAPPD 1097

Query: 608  LSPPRGLVAVRTPRGVLLHWDP-PEL 632
            ++P    +   +   + L W P PE+
Sbjct: 1098 MAPANVSLRTASETSLWLRWMPLPEM 1123



 Score = 34.3 bits (77), Expect = 0.71
 Identities = 47/159 (29%), Positives = 62/159 (38%), Gaps = 21/159 (13%)

Query: 558  LQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAV 617
            L  +T Y  SV A N  G GP      S P    T  AAP  P +     L         
Sbjct: 1690 LTGYTAYMVSVAAFNAAGDGP-----RSTPTQGQTQQAAPSAPSSVKFSEL--------- 1735

Query: 618  RTPRGVLLHWDPPELVPKRLDGY--VLEGRQGSQG-WEVLDPAVAG-TETELLVPGLIKD 673
             T   V + W+ P+     L+GY  V E      G  +++   V G +   L V  L + 
Sbjct: 1736 -TTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794

Query: 674  VLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLP 712
            V Y FR+   A +F   P   ANV+T   E  P    +P
Sbjct: 1795 VTYRFRI--RAKTFTYGPEIEANVTTGPGEGAPGPPGVP 1831



 Score = 33.9 bits (76), Expect = 0.93
 Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 25/184 (13%)

Query: 503  LPKGANVSW-EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561
            L     VSW EPG   G L  + + +    +   R+ H      +P       V GL   
Sbjct: 907  LDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTH-----YLPNVTLEYRVTGLTAL 961

Query: 562  TQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621
            T Y   V A    G G  S   +S+  G+P  P  PG PPT +          ++   PR
Sbjct: 962  TTYTIEVAAMTSKGQGQVSASTISS--GVP--PELPG-PPTNLG---------ISNIGPR 1007

Query: 622  GVLLHWDPPELVPKRLDGYVLEGRQGSQG----WEVLDPAVAGTETELL-VPGLIKDVLY 676
             V L + P       +  +++E + G  G    W ++       +   + VP L     Y
Sbjct: 1008 SVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067

Query: 677  EFRL 680
             FR+
Sbjct: 1068 SFRM 1071



 Score = 31.2 bits (69), Expect = 6.0
 Identities = 49/181 (27%), Positives = 68/181 (37%), Gaps = 23/181 (12%)

Query: 325 VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ---GTEGSLIIALGNEDALGEYSCTP 381
           VIR P  A+ P   V+W +DG+     K P  S+     E +L+I        G Y    
Sbjct: 131 VIRAPRIASFPQPQVTWFRDGR-----KIPPSSRIAITLENTLVILSTVAPDAGRYYVQA 185

Query: 382 YNSLG----TAGPSPVTRVLLKAP-----PAFIERPKEEYFQEVGRELLIPCSAQGDP-- 430
            N       T+ P  +T   +  P     P  I  PK         E+ + C A   P  
Sbjct: 186 VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLI 245

Query: 431 PPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSA---SNAVARVATSTNVYV 487
              + W K G  L G    D N  L +   T    G++EC A   S++V  V     + V
Sbjct: 246 KLHIIWKKDGVLLSGGIS-DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304

Query: 488 L 488
           L
Sbjct: 305 L 305


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  120 bits (300), Expect = 1e-26
 Identities = 179/714 (25%), Positives = 268/714 (37%), Gaps = 116/714 (16%)

Query: 25  EVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84
           E V  +   G SV+L C     A   P   IEW + G  L +          +  D   R
Sbjct: 58  EPVDTLSVRGSSVILNCS----AYSEPSPKIEWKKDGTFLNL----------VSDD---R 100

Query: 85  VRLQKGASLQIEGL-----RVEDQGWYEC--RVFFLDQHIPEDDFANGSWVHLTVNSPPQ 137
            +L    SL I  +        D+G+Y+C   V  L   I            L V   P+
Sbjct: 101 RQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRT-------AKLIVAGLPR 153

Query: 138 FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
           F   P     V       L C      +P V W+   + L      +++ +G L I    
Sbjct: 154 FTSQPEPS-SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT 212

Query: 198 RGSSGVYTCQASST-EGSATHATQLLVLGPP------VIVVPPKNSTVNASQDVSLACHA 250
            G  G+Y C   S      +   +L VL  P      V +  P        QDV L C A
Sbjct: 213 EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVA 272

Query: 251 EAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
              P   T  W ++   +   S    R+ +L  GSL +     DDAG Y C+  NG    
Sbjct: 273 SGLPTP-TIKWMKNEEALDTES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGN-ET 328

Query: 311 PSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGK-ALQLDKFP 354
             A A LTV   P  ++ P                    P   V W K+G   +  D F 
Sbjct: 329 IEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK 388

Query: 355 GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA---FIERPKEE 411
              +     L +   +E   G Y C   N +G A       +L  AP         P++ 
Sbjct: 389 IVKEHNLQVLGLVKSDE---GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDV 445

Query: 412 YFQEVGRELL-----IPCS-AQGDPPPV-VSWTKVGRGLQ--------GQAQVDSNSSL- 455
               V    +      P S   GD     V +TK G   +        G+ QV   + + 
Sbjct: 446 VASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMP 505

Query: 456 ----ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSW 511
               I R + +  HG  E   S+A  RV T   V + G +P++    +  A P    V+W
Sbjct: 506 ATVYIFRVMAQNKHGSGE---SSAPLRVETQPEVQLPGPAPNLR---AYAASPTSITVTW 559

Query: 512 EPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570
           E    G G +Q + ++Y  + K  D+         V V +    + GL+ +T+Y F V+A
Sbjct: 560 ETPVSGNGEIQNYKLYY--MEKGTDKEQD------VDVSSHSYTINGLKKYTEYSFRVVA 611

Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630
            NK G G      +S P+    T +     P+  P  LS     + VR  + +++HW PP
Sbjct: 612 YNKHGPG------VSTPDVAVRTLSDV---PSAAPQNLS-----LEVRNSKSIMIHWQPP 657

Query: 631 ELVPK--RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
               +  ++ GY +  R+ S+  +V +  V+GT+   L+ GL +   Y FR+ A
Sbjct: 658 APATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711



 Score =  107 bits (267), Expect = 7e-23
 Identities = 150/607 (24%), Positives = 225/607 (37%), Gaps = 84/607 (13%)

Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK--DLGQGQGQVQVQNGTL 191
           +P  F   P   L V+    V L C A   P P + WK  G   +L     +  + +G+L
Sbjct: 51  TPFYFLVEPVDTLSVRG-SSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSL 109

Query: 192 RIRRV-----ERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDV 244
            I  V      +   G Y C A+  S     +   +L+V G P     P+ S+V A  + 
Sbjct: 110 FISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNA 169

Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304
            L C   A        W Q+   +     L  RV  L  G L +      D G Y CV  
Sbjct: 170 ILNCEVNADLVPFV-RWEQNRQPLL----LDDRVIKLPSGMLVISNATEGDGGLYRCVVE 224

Query: 305 NG------------LLHPPSASAYLTVLCMPG----------VIRCPVRANPPLLFVSWT 342
           +G            +L  P   + L  L  P           V+ C V +  P   + W 
Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWM 283

Query: 343 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 402
           K+ +AL  +          GSL I+   ED  G Y C   N  G         + ++A P
Sbjct: 284 KNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN--GNETIEAQAELTVQAQP 341

Query: 403 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPL 460
            F+++P   Y  E   +++  C   G P P V W K G  +      ++    +L +  L
Sbjct: 342 EFLKQPTNIYAHE-SMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 400

Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN--------VSVVALPKGANVSWE 512
            K   G ++C A N V        + +L  +P             V+ +   +   ++W 
Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460

Query: 513 -PGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570
            P  D  G    +SV+YT      +R+ +         G   + +  L P T Y F V+A
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVEN-----TSHPGEMQVTIQNLMPATVYIFRVMA 515

Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630
           QNK GSG       SAP  + T       P  ++P P    R   A  +P  + + W+ P
Sbjct: 516 QNKHGSGE-----SSAPLRVETQ------PEVQLPGPAPNLRAYAA--SPTSITVTWETP 562

Query: 631 ELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--A 684
                 +  Y L    +G    Q  +V       +     + GL K   Y FR+VA+   
Sbjct: 563 VSGNGEIQNYKLYYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKH 615

Query: 685 GSFVSDP 691
           G  VS P
Sbjct: 616 GPGVSTP 622



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 125/563 (22%), Positives = 218/563 (38%), Gaps = 105/563 (18%)

Query: 208 ASSTEGSATHA--TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
           A++  GSA  +    +    P   +V P ++       V L C A + P+     W +D 
Sbjct: 32  AAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSP-KIEWKKDG 90

Query: 266 INVFHISRLQPRVRILVDGSLRLLAT------QPDDAGCYTCVPS-NGLLHPPSASAYLT 318
             +  +S    R ++L DGSL +         +PD+ G Y CV +   L    S +A L 
Sbjct: 91  TFLNLVS--DDRRQLLPDGSLFISNVVHSKHNKPDE-GYYQCVATVESLGTIISRTAKLI 147

Query: 319 VLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQLD----KFPGWSQ 358
           V  +P                 ++ C V A+  + FV W ++ + L LD    K P    
Sbjct: 148 VAGLPRFTSQPEPSSVYAGNNAILNCEVNADL-VPFVRWEQNRQPLLLDDRVIKLPS--- 203

Query: 359 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPP--------AFIERPK 409
              G L+I+   E   G Y C     + + GP   +  V LK  P         F+++P 
Sbjct: 204 ---GMLVISNATEGDGGLYRCV----VESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256

Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQ----VDSNSSLILRPLTKEAH 465
               + +G+++++PC A G P P + W K    L  ++     + +  SL +  +T++  
Sbjct: 257 P-LVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDA 315

Query: 466 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSV 525
           G + C A N    +     + V    P  +   + +   +  ++ +E    G        
Sbjct: 316 GTYFCIADNGNETIEAQAELTV-QAQPEFLKQPTNIYAHESMDIVFECEVTGK------- 367

Query: 526 WYTPLAKRPDRMHHDWV---SLAVP------VGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576
             TP  K        WV    + +P      V   +L V GL    +  +  +A+N +G+
Sbjct: 368 -PTPTVK--------WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418

Query: 577 GPF-SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP- 634
               +++++     L   PA  G      P P +P   + ++ + R + L W  P   P 
Sbjct: 419 AQAGAQLII-----LEHAPATTG------PLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467

Query: 635 -KRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSN 693
              L   V   ++G     V + +  G E ++ +  L+   +Y FR++A       + S 
Sbjct: 468 GDNLTYSVFYTKEGIARERVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526

Query: 694 TANVSTSGLEVYPSRTQLPGLLP 716
              V T          QLPG  P
Sbjct: 527 PLRVETQ------PEVQLPGPAP 543



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 35/211 (16%)

Query: 24  PEVVS----------VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
           PEV+S          +V   G+ VVL C     A   P   I+W++              
Sbjct: 243 PEVISDLVFLKQPSPLVRVIGQDVVLPC----VASGLPTPTIKWMK-------------N 285

Query: 74  SPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN 133
              +D +   R+ L  G SL+I  +  +D G Y C     ++ I        +   LTV 
Sbjct: 286 EEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-------AQAELTVQ 338

Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI 193
           + P+F + P  +   + ++ +   C   G P P V W   G  +        V+   L++
Sbjct: 339 AQPEFLKQPTNIYAHESMD-IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQV 397

Query: 194 RRVERGSSGVYTCQASSTEGSATHATQLLVL 224
             + +   G Y C A +  G+A    QL++L
Sbjct: 398 LGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 5/113 (4%)

Query: 473  SNAVARVATSTNVYVLGTSPHV-VTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPL 530
            S+  +  A  T   ++ TSP   VT VS    PK   V+W+P  +  G +  + ++Y+  
Sbjct: 938  SSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTD 997

Query: 531  AKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
                    HDWV   V        +  L   T Y F + A+N  G GP SE V
Sbjct: 998  VNAEI---HDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 24/136 (17%)

Query: 554  LVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRG 613
            LV GL+P+T Y+FSV+      S  +S         L                P SPP+ 
Sbjct: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL---------------VPTSPPKD 960

Query: 614  LVAVR---TPRGVLLHWDPPELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELL 666
            +  V     P+ ++++W PP     ++ GY++    +       W V++P V G      
Sbjct: 961  VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDW-VIEP-VVGNRLTHQ 1018

Query: 667  VPGLIKDVLYEFRLVA 682
            +  L  D  Y F++ A
Sbjct: 1019 IQELTLDTPYYFKIQA 1034


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  117 bits (294), Expect = 5e-26
 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)

Query: 13  VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
           ++++GA    K  V  V    GESVVL C+  PP    PL +  W+    L         
Sbjct: 125 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 172

Query: 73  YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
               I  D   RV + +  +L    +   D    Y C   F     + Q  P D     +
Sbjct: 173 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 227

Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
              +       F     + L   + +P+ L C+A G P P + W      +   +   Q 
Sbjct: 228 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 287

Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
            N TL++ +V     G Y C A ++ GSA HA  + V   P  +  P++      +   L
Sbjct: 288 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 347

Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
            C  +  P     +W  + I V  +++ Q + RI   G+L L   QP D     C   N 
Sbjct: 348 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 404

Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
            GLL    A+AY+ V+ +P  I                         P+  V W  +DG 
Sbjct: 405 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 461

Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
             LQ ++F  ++ GT G  I  L   D  G Y C   N       + +  + +K      
Sbjct: 462 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 516

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
           + P+    ++ G  +   C A  DP   P ++W   GR LQ     D     +  L++  
Sbjct: 517 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 575

Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
           L     G++ C AS  +  V +   + V+G+    P +V +   +       VSW P  D
Sbjct: 576 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 635

Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
               ++++ + +      P++    W SL    G        L P+  Y F V A NK G
Sbjct: 636 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 691

Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
            G  S +     E + T  AAP   P ++    +    +V    P    + W+ P++   
Sbjct: 692 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 743

Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
               Y ++ R QG++G W+   V DP +  + T   VP  IK
Sbjct: 744 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 782



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)

Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
           L C A G+P+P V W    G  + Q +      NGTL IR ++   +G Y C A++ + +
Sbjct: 441 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 500

Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
            T    L V     I   P+++       V+  C A   P+   + +W  D  ++  +  
Sbjct: 501 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 560

Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
                  + DG L + +    D G Y+CV S  L     + A L V+  PG +   V ++
Sbjct: 561 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 617

Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
             LL      VSW+                + K +  +K+   G   G + S  + L + 
Sbjct: 618 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 676

Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
                +  T  N  G   PSPV+  ++    A  + P +   +  G E   ++I      
Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 734

Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
               + P V   V W   G     Q Q+ S+  L++   +       +  A N+  +   
Sbjct: 735 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 794

Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
              T  Y     P  +  +  + +   + V   W P       G+L+ ++V  W     +
Sbjct: 795 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 854

Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
           +  + H     + VP     +++ GL+P++ Y   V A N  GSGP SE   S PEG+P 
Sbjct: 855 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 914

Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
            P A  L                  ++   +LL W PP      L GYVL      EG +
Sbjct: 915 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 958

Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
           G   + + DP +       L P L     Y F+L A
Sbjct: 959 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 990



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 95/410 (23%), Positives = 157/410 (38%), Gaps = 61/410 (14%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQVQN 188
           PP   E  P  L V   + ++L+C A G P     W   G      ++LG    Q    +
Sbjct: 29  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-SPHS 87

Query: 189 GTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST----VN 239
           G+  I        +   G+Y C AS+  G+A +H  +L+  G P     PK +     V 
Sbjct: 88  GSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVE 144

Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQPDD 295
             + V L C+       L   W   N  + HI +   RV +  +G+L     L +    D
Sbjct: 145 EGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDNHSD 201

Query: 296 AGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIRCPV 330
             C+   P                           LL P ++S++L  L   P V+ C +
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC-I 260

Query: 331 RANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390
               P   + W +    +  D+   +    +   ++ +G ED  GEY C   NSLG+A  
Sbjct: 261 AEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGSA-- 316

Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD 450
                V ++A P ++ +P+   +   G    + C  QG P P V+W   G  ++  A+  
Sbjct: 317 RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ 375

Query: 451 ----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
                  +LIL  +        +C A N    +  +  +YV+     ++T
Sbjct: 376 KYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 425


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  117 bits (294), Expect = 5e-26
 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)

Query: 13  VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
           ++++GA    K  V  V    GESVVL C+  PP    PL +  W+    L         
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177

Query: 73  YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
               I  D   RV + +  +L    +   D    Y C   F     + Q  P D     +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232

Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
              +       F     + L   + +P+ L C+A G P P + W      +   +   Q 
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292

Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
            N TL++ +V     G Y C A ++ GSA HA  + V   P  +  P++      +   L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352

Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
            C  +  P     +W  + I V  +++ Q + RI   G+L L   QP D     C   N 
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409

Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
            GLL    A+AY+ V+ +P  I                         P+  V W  +DG 
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466

Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
             LQ ++F  ++ GT G  I  L   D  G Y C   N       + +  + +K      
Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
           + P+    ++ G  +   C A  DP   P ++W   GR LQ     D     +  L++  
Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580

Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
           L     G++ C AS  +  V +   + V+G+    P +V +   +       VSW P  D
Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640

Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
               ++++ + +      P++    W SL    G        L P+  Y F V A NK G
Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696

Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
            G  S +     E + T  AAP   P ++    +    +V    P    + W+ P++   
Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748

Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
               Y ++ R QG++G W+   V DP +  + T   VP  IK
Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)

Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
           L C A G+P+P V W    G  + Q +      NGTL IR ++   +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505

Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
            T    L V     I   P+++       V+  C A   P+   + +W  D  ++  +  
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565

Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
                  + DG L + +    D G Y+CV S  L     + A L V+  PG +   V ++
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622

Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
             LL      VSW+                + K +  +K+   G   G + S  + L + 
Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681

Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
                +  T  N  G   PSPV+  ++    A  + P +   +  G E   ++I      
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739

Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
               + P V   V W   G     Q Q+ S+  L++   +       +  A N+  +   
Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799

Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
              T  Y     P  +  +  + +   + V   W P       G+L+ ++V  W     +
Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859

Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
           +  + H     + VP     +++ GL+P++ Y   V A N  GSGP SE   S PEG+P 
Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919

Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
            P A  L                  ++   +LL W PP      L GYVL      EG +
Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963

Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
           G   + + DP +       L P L     Y F+L A
Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%)

Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
           V  PP   E  P  L V   + ++L+C A G P     W   G      ++LG    Q  
Sbjct: 31  VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89

Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
             +G+  I        +   G+Y C AS+  G+A +H  +L+  G P     PK +    
Sbjct: 90  PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146

Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
            V   + V L C+       L   W   N  + HI +   RV +  +G+L     L +  
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203

Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327
             D  C+   P                           LL P ++S++L  L   P V+ 
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263

Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
           C +    P   + W +    +  D+   +    +   ++ +G ED  GEY C   NSLG+
Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320

Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447
           A       V ++A P ++ +P+   +   G    + C  QG P P V+W   G  ++  A
Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377

Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
           +         +LIL  +        +C A N    +  +  +YV+     ++T
Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  117 bits (294), Expect = 5e-26
 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)

Query: 13  VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
           ++++GA    K  V  V    GESVVL C+  PP    PL +  W+    L         
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177

Query: 73  YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
               I  D   RV + +  +L    +   D    Y C   F     + Q  P D     +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232

Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
              +       F     + L   + +P+ L C+A G P P + W      +   +   Q 
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292

Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
            N TL++ +V     G Y C A ++ GSA HA  + V   P  +  P++      +   L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352

Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
            C  +  P     +W  + I V  +++ Q + RI   G+L L   QP D     C   N 
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409

Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
            GLL    A+AY+ V+ +P  I                         P+  V W  +DG 
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466

Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
             LQ ++F  ++ GT G  I  L   D  G Y C   N       + +  + +K      
Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
           + P+    ++ G  +   C A  DP   P ++W   GR LQ     D     +  L++  
Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580

Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
           L     G++ C AS  +  V +   + V+G+    P +V +   +       VSW P  D
Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640

Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
               ++++ + +      P++    W SL    G        L P+  Y F V A NK G
Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696

Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
            G  S +     E + T  AAP   P ++    +    +V    P    + W+ P++   
Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748

Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
               Y ++ R QG++G W+   V DP +  + T   VP  IK
Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)

Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
           L C A G+P+P V W    G  + Q +      NGTL IR ++   +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505

Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
            T    L V     I   P+++       V+  C A   P+   + +W  D  ++  +  
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565

Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
                  + DG L + +    D G Y+CV S  L     + A L V+  PG +   V ++
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622

Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
             LL      VSW+                + K +  +K+   G   G + S  + L + 
Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681

Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
                +  T  N  G   PSPV+  ++    A  + P +   +  G E   ++I      
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739

Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
               + P V   V W   G     Q Q+ S+  L++   +       +  A N+  +   
Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799

Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
              T  Y     P  +  +  + +   + V   W P       G+L+ ++V  W     +
Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859

Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
           +  + H     + VP     +++ GL+P++ Y   V A N  GSGP SE   S PEG+P 
Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919

Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
            P A  L                  ++   +LL W PP      L GYVL      EG +
Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963

Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
           G   + + DP +       L P L     Y F+L A
Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%)

Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
           V  PP   E  P  L V   + ++L+C A G P     W   G      ++LG    Q  
Sbjct: 31  VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89

Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
             +G+  I        +   G+Y C AS+  G+A +H  +L+  G P     PK +    
Sbjct: 90  PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146

Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
            V   + V L C+       L   W   N  + HI +   RV +  +G+L     L +  
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203

Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327
             D  C+   P                           LL P ++S++L  L   P V+ 
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263

Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
           C +    P   + W +    +  D+   +    +   ++ +G ED  GEY C   NSLG+
Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320

Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447
           A       V ++A P ++ +P+   +   G    + C  QG P P V+W   G  ++  A
Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377

Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
           +         +LIL  +        +C A N    +  +  +YV+     ++T
Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  117 bits (294), Expect = 5e-26
 Identities = 94/365 (25%), Positives = 150/365 (41%), Gaps = 35/365 (9%)

Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ--VQNGTLRIRRVERGS 200
           P   +V     V   C A G+P P + W     +L          + +GTL I+  +   
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311

Query: 201 SGVYTCQASSTEGSA-THATQLLVLGPPV---IVVPPKNSTVNASQDVSLACHAEAYPAN 256
            G+Y C A +  G   T    L   G P     V+ P+N+ V   + V+L C A  +P  
Sbjct: 312 QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371

Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
              SW + +     +    PRV I   G L +      D+G Y C  +N +     A+A+
Sbjct: 372 -RISWTRGDRTPLPVD---PRVNITPSGGLYIQNVVQGDSGEYACSATNNI-DSVHATAF 426

Query: 317 LTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQLDK-FPGWSQG 359
           + V  +P                   +C  + NPP + ++WTK G  L +D+     S G
Sbjct: 427 IIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWTKGGSQLSVDRRHLVLSSG 485

Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
           T     +AL ++   G+Y C   N +G+        V  +  P F   P +    EVG  
Sbjct: 486 TLRISGVALHDQ---GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGAN 541

Query: 420 LLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVA 477
           + +PCS+QG+P P ++W K G  +   G+  +     L +  +     G +EC A N + 
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601

Query: 478 RVATS 482
             + S
Sbjct: 602 SASVS 606



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 82/279 (29%), Positives = 112/279 (40%), Gaps = 43/279 (15%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           GESV L C      G PP   I W R G   P+          +DP    RV +     L
Sbjct: 356 GESVTLECSA---TGHPPPR-ISWTR-GDRTPL---------PVDP----RVNITPSGGL 397

Query: 94  QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
            I+ +   D G Y C        +    F       + V + PQF  TP   + + E + 
Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAF-------IIVQALPQFTVTPQDRVVI-EGQT 449

Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
           V  +C A+G+P P + W   G  L   +  + + +GTLRI  V     G Y CQA +  G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509

Query: 214 SATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--- 268
           S      L V     PV    P ++TV    +V L C ++  P     +W +D + V   
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEP-EPAITWNKDGVQVTES 568

Query: 269 --FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN 305
             FHIS          +G L +    P DAG Y CV  N
Sbjct: 569 GKFHIS---------PEGFLTINDVGPADAGRYECVARN 598



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 87/332 (26%), Positives = 135/332 (40%), Gaps = 32/332 (9%)

Query: 84  RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
           R+ L    +L I+  +  DQG Y+C    +   +   +    +  +    + P F    P
Sbjct: 293 RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEV---TLRYFGSPARPTF-VIQP 348

Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSG 202
              EV   E VTL C A G P P ++W    +       +V +  +G L I+ V +G SG
Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSG 408

Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
            Y C A++   S      ++V   P   V P++  V   Q V   C A+  P  +  +W 
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWT 467

Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV--- 319
           +    +     +  R  +L  G+LR+      D G Y C   N ++      A+LTV   
Sbjct: 468 KGGSQL----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVN-IIGSQKVVAHLTVQPR 522

Query: 320 -----LCMPGVIRCPVRAN---------PPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
                  +P      V AN          P   ++W KDG  +Q+ +   +    EG L 
Sbjct: 523 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPEGFLT 580

Query: 366 I-ALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
           I  +G  DA G Y C   N++G+A  S V  V
Sbjct: 581 INDVGPADA-GRYECVARNTIGSASVSMVLSV 611



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 63/282 (22%), Positives = 107/282 (37%), Gaps = 15/282 (5%)

Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
           C    NP    + W ++   L +      +   +G+L+I    E   G Y C   N  G 
Sbjct: 267 CRAEGNPKPEII-WLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGE 325

Query: 388 AGPSPVTRVLLKAP--PAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--- 442
                VT     +P  P F+ +P+      VG  + + CSA G PPP +SWT+  R    
Sbjct: 326 VKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESVTLECSATGHPPPRISWTRGDRTPLP 384

Query: 443 LQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVA 502
           +  +  +  +  L ++ + +   G + CSA+N +  V  +  + V       VT    V 
Sbjct: 385 VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVV 444

Query: 503 LPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562
           + +G  V ++    G      +          DR H       + + +  L + G+  H 
Sbjct: 445 I-EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH-------LVLSSGTLRISGVALHD 496

Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEI 604
           Q Q+   A N +GS      +   P   P   + P     E+
Sbjct: 497 QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV 538



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 56/200 (28%), Positives = 82/200 (41%), Gaps = 35/200 (17%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           G++V   C+     G PP  VI W + G  L +  +  + S                 +L
Sbjct: 447 GQTVDFQCEA---KGNPP-PVIAWTKGGSQLSVDRRHLVLS---------------SGTL 487

Query: 94  QIEGLRVEDQGWYECRVFFL--DQHIPEDDFANGSWVHLTVNS--PPQFQETPPAVLEVQ 149
           +I G+ + DQG YEC+   +   Q +           HLTV     P F   P     V+
Sbjct: 488 RISGVALHDQGQYECQAVNIIGSQKVV---------AHLTVQPRVTPVFASIPSDTT-VE 537

Query: 150 ELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSSGVYTCQA 208
               V L C ++G P P +TW   G  + +  G+  +   G L I  V    +G Y C A
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVGPADAGRYECVA 596

Query: 209 SSTEGSATHATQLLVLGPPV 228
            +T GSA+ +  L V  P V
Sbjct: 597 RNTIGSASVSMVLSVNVPDV 616


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
           [Homo sapiens]
          Length = 1224

 Score =  115 bits (289), Expect = 2e-25
 Identities = 153/651 (23%), Positives = 245/651 (37%), Gaps = 101/651 (15%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           G+ +VL C+  PP G PPLH+  W+                  I+ D   RV + +   L
Sbjct: 146 GDPIVLPCN--PPKGLPPLHIY-WMNIEL------------EHIEQDE--RVYMSQKGDL 188

Query: 94  QIEGLRVEDQGWYEC------RVFFLDQHIP----------EDDFANGSWVHLTVNSPPQ 137
               +  +D     C      R+  + Q +P           +D ++ + +    NS  Q
Sbjct: 189 YFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQ 248

Query: 138 FQET---PP------AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN 188
            +     PP      + + + + E + L C A G P P V W   G DL +G+   +   
Sbjct: 249 RKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYG 308

Query: 189 GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
            TL+I  V     G Y C AS+  G+ATH   ++V  PP     P+++  +   +  L C
Sbjct: 309 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 368

Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--- 305
            AE  P   T  W    +N   +        ++    +     QP+    Y C  SN   
Sbjct: 369 EAEGEP-QPTIKW---RVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHG 424

Query: 306 --------------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTK--DGKALQ 349
                          L+       Y TV+     + C   A+P  + VSW K  + K L+
Sbjct: 425 TILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAV-VSWQKVEEVKPLE 483

Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG----TAGPSPVTRVLLKAPPAFI 405
             ++  +  GT   L I    E+  G YSC   N++G    TA         L+  P   
Sbjct: 484 GRRYHIYENGT---LQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSP--- 537

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-----SNSSLILRPL 460
           + P+      +       C +       +SW+K G   +     D       ++L +  +
Sbjct: 538 KNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNV 597

Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-KGANVSWEPGFD-GG 518
           T E  G + CSA  A+   A  T V VL   P    N+ +     +   ++WE G D   
Sbjct: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV-PDPPENLHLSERQNRSVRLTWEAGADHNS 656

Query: 519 YLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGP 578
            +  + V +    + P R    W  L    G    ++  L P  +YQF V+A N++G   
Sbjct: 657 NISEYIVEFEGNKEEPGR----WEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQ 712

Query: 579 FSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
            S+      +   T PAAP   P  I          V    P+ +++ W+P
Sbjct: 713 PSQ----PSDHHETPPAAPDRNPQNI---------RVQASQPKEMIIKWEP 750



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 175/755 (23%), Positives = 279/755 (36%), Gaps = 140/755 (18%)

Query: 43  LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG-------RVRLQKGASLQI 95
           LLPP        I  L+   LL      GL +P++D + +G         +   G +L+I
Sbjct: 254 LLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKI 313

Query: 96  EGLRVEDQGWYECRVF-FLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPV 154
           E +  +D+G Y C    FL       DF      H+ V  PP++ + P + +       +
Sbjct: 314 ENVSYQDKGNYRCTASNFLGT--ATHDF------HVIVEEPPRWTKKPQSAVYSTGSNGI 365

Query: 155 TLRCVARGSPLPHVTWKLRGKDLGQGQ--GQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
            L C A G P P + W++ G  +      G V V    +    ++   + VY C+AS+  
Sbjct: 366 LL-CEAEGEPQPTIKWRVNGSPVDNHPFAGDV-VFPREISFTNLQPNHTAVYQCEASNVH 423

Query: 213 GS--ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFH 270
           G+  A     ++ + P +     +N          L C   A P  +  SW +       
Sbjct: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVV-SWQK------- 475

Query: 271 ISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGL--------LHPPSASAYLT 318
           +  ++P    R  I  +G+L++  T  +DAG Y+C   N +        L   +A+    
Sbjct: 476 VEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRV 535

Query: 319 VLCMPGV-------IRCPVRANPPL---LFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
               P +       + C  + +  L   L +SW+KDG+A +++       GTE   II  
Sbjct: 536 SPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEIN-------GTEDGRIIID 588

Query: 369 GNEDAL--------GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE-VGRE 419
           G    +        G Y C+ + +L +A  + +T+V +   P   + P+  +  E   R 
Sbjct: 589 GANLTISNVTLEDQGIYCCSAHTALDSA--ADITQVTVLDVP---DPPENLHLSERQNRS 643

Query: 420 LLIPCSAQGDPPPVVSWTKV---------GRGLQGQAQVDSNSSLILRPLTKEAHGHWEC 470
           + +   A  D    +S   V         GR  +   +V    + ++ PL       +  
Sbjct: 644 VRLTWEAGADHNSNISEYIVEFEGNKEEPGRW-EELTRVQGKKTTVILPLAPFVRYQFRV 702

Query: 471 SASNAVARVATSTNVYVLGTSPHVVT----NVSVVAL-PKGANVSWEP----GFDGGYLQ 521
            A N V R   S       T P        N+ V A  PK   + WEP      +G  L+
Sbjct: 703 IAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLE 762

Query: 522 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSE 581
               W      +P     +W    V      ++ P +  +  Y   V A N+LGSGP   
Sbjct: 763 YRVTW------KPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSGP--- 811

Query: 582 IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD--PPELVPKRLDG 639
                       P +  L   E  P  +P    V V     V + W   P + V  RL G
Sbjct: 812 -----------DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKG 860

Query: 640 Y---------VLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690
           Y         +L+GR   +   +L    +G     +VP L  D   EF L   A      
Sbjct: 861 YQINWWKTKSLLDGRTHPKEVNIL--RFSGQRNSGMVPSL--DAFSEFHLTVLA------ 910

Query: 691 PSNTANVSTSGLEVYPSRTQLP-GLLPQPVLAGVV 724
                N   +G E  P   Q P G+  QP    V+
Sbjct: 911 ----YNSKGAGPESEPYIFQTPEGVPEQPTFLKVI 941



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 95/417 (22%), Positives = 147/417 (35%), Gaps = 73/417 (17%)

Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTW-KLRGKDLGQGQGQVQ 185
           +   V S P+F +     LEV+E +P+ L C   +G P  H+ W  +  + + Q +    
Sbjct: 123 IEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYM 182

Query: 186 VQNGTLRIRRV-ERGSSGVYTCQAS--------------STEGSATHA------------ 218
            Q G L    V E+ S   Y C A+               T  S  HA            
Sbjct: 183 SQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSK 242

Query: 219 TQLLVLGPPVIVVPPKNS------TVNASQDVSLACHAEAYPANLTYSWFQDNINVFHIS 272
              +    P +++PP  S      T+   + + L C AE  P           ++   I 
Sbjct: 243 ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPT--------PQVDWNKIG 294

Query: 273 RLQPRVRILVDG---SLRLLATQPDDAGCYTCVPSNGL-----------------LHPPS 312
              P+ R   +    +L++      D G Y C  SN L                    P 
Sbjct: 295 GDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQ 354

Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-WSQGTEGSLIIALGNE 371
           ++ Y T     G++ C     P    + W  +G  +    F G      E S      N 
Sbjct: 355 SAVYST--GSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNH 411

Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPP 431
            A+  Y C   N  GT   +    V +   P    +  E Y   VG    + C     P 
Sbjct: 412 TAV--YQCEASNVHGTILANANIDV-VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 468

Query: 432 PVVSWTKVG--RGLQGQA-QVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
            VVSW KV   + L+G+   +  N +L +   T+E  G + C   NA+ + A + N+
Sbjct: 469 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 17/112 (15%)

Query: 390 PSPVTRV--LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--LQG 445
           PS V +V  ++K     +  P +EYFQ       I C A+G+P P  SWTK G       
Sbjct: 28  PSSVQQVPTIIKQSKVQVAFPFDEYFQ-------IECEAKGNPEPTFSWTKDGNPFYFTD 80

Query: 446 QAQVDSNSSLILRPLTKEAH-----GHWECSASNAVARVATSTNVYVLGTSP 492
              + SN+S   R +  E H     G + C ASN +    +    +++ + P
Sbjct: 81  HRIIPSNNSGTFR-IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVP 131


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score =  115 bits (288), Expect = 2e-25
 Identities = 139/582 (23%), Positives = 233/582 (40%), Gaps = 75/582 (12%)

Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI-----RRVE 197
           P  + V   +PV L C A G     VTW   G  + + +    + NG+L I     RR E
Sbjct: 45  PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104

Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGP-PVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
           +   G Y C A +  G+       L L       V P ++ V+       AC   ++P  
Sbjct: 105 QSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPP- 163

Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
              +W     N   +     R+  L  G L++      D+G Y C+ +       S  A 
Sbjct: 164 AVITW---EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEAS 220

Query: 317 LTV------------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLD 351
           LTV                        L    V+ C    NP  + +SW++ D K+  +D
Sbjct: 221 LTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPI-ISWSRLDHKS--ID 277

Query: 352 KFPGWSQGTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
            F     G  G+L+I+       G Y C   TP     T   + +T   + APP+F+E P
Sbjct: 278 VFNTRVLG-NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT---VLAPPSFVEWP 333

Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDS-NSSLILRPLTKEAHGH 467
           +       G    + C A+G P P +SW K GR +    ++   NS L++  +  E    
Sbjct: 334 ESLTRPRAGTARFV-CQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392

Query: 468 WECSASNAVARVATSTNVYVLGTS--PHVVTNVSVVALPKGA-NVSWE-PGFDGGYLQRF 523
           ++C A N+   + +   + V+ +   P    NV    +   A  ++WE P ++   +  +
Sbjct: 393 YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAY 452

Query: 524 SVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
           SV Y     + + ++++   + +     H ++  L+P + Y F ++A   +G+   S+ V
Sbjct: 453 SVHY----MKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508

Query: 584 LSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKR--LDGYV 641
                             T    PL PP   +  R+P  +L+ W P     +R  +  Y 
Sbjct: 509 TQ---------------NTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553

Query: 642 LEGRQGSQ-GWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
           L  R  ++   +VL+  + GT  E L+ GL  D +Y  R+ A
Sbjct: 554 LSFRLSTENSIQVLE--LPGTTHEYLLEGLKPDSVYLVRITA 593



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 7/122 (5%)

Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616
           GL P  +Y   +LA N +  G  ++  +S       TP    +    +PPP  P      
Sbjct: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVS-------TPGCVSVRDRMVPPPPPPHHLYAK 731

Query: 617 VRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLY 676
             T   + LHW  P     ++  Y +           L   +  +ET +LV GL  +  Y
Sbjct: 732 ANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKY 791

Query: 677 EF 678
           EF
Sbjct: 792 EF 793



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 59/263 (22%), Positives = 101/263 (38%), Gaps = 36/263 (13%)

Query: 513 PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 572
           P F    +  +++   P+      + +  + L +     H+LV GL+P+T+Y+F+V    
Sbjct: 745 PAFTAAQIINYTIRCNPVG-----LQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHV 799

Query: 573 KLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPL-SPPRGLVAVRTPRGVLLHWDPPE 631
              S P+S +V  +     T P AP  PP  +   L      LV+ + P       D PE
Sbjct: 800 DQLSSPWSPVVYHS-----TLPEAPAGPPVGVKVTLIEDDTALVSWKPP-------DGPE 847

Query: 632 LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690
            V  R        +    G W+VL     G  T  L+  L+   +Y  ++ A        
Sbjct: 848 TVVTRYTILYASRKAWIAGEWQVLHR--EGAITMALLENLVAGNVYIVKISASNEVGEGP 905

Query: 691 PSNTANVSTSGLEVYPSRTQLPGL-------------LPQPVLAGVVGGVCFLGVAVLVS 737
            SN+  ++    E   S  +   L             L Q  + G+  GV      +L+ 
Sbjct: 906 FSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILIC 965

Query: 738 ILAGCLLNRRRAARRRRKRLRQD 760
           +L   L+ R +A +    +  Q+
Sbjct: 966 VL--ILIYRSKARKSSASKTAQN 986


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
           precursor [Homo sapiens]
          Length = 2012

 Score =  115 bits (288), Expect = 2e-25
 Identities = 122/471 (25%), Positives = 201/471 (42%), Gaps = 92/471 (19%)

Query: 87  LQKGASLQIEGLRVE----------DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
           L  G +++I G+  E          D G Y+C  F     +   D+     V L   +P 
Sbjct: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAYQC--FVRKDKLSAQDYVQ---VVLEDGTPK 408

Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQNGT-- 190
                   V  V   EPV+L C  +G+PLP +TW L    + +G      Q+    G   
Sbjct: 409 IISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466

Query: 191 --LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
             L I   +    GVY C A+++ G   +  ++ V G P  + P KN T  A +D  + C
Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHC 525

Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGL 307
               YP   +  W++ N N+   +  Q  V    +G+L+L   Q + D G YTC   N L
Sbjct: 526 RVIGYP-YYSIKWYK-NSNLLPFNHRQ--VAFENNGTLKLSDVQKEVDEGEYTC---NVL 578

Query: 308 LHP---PSASAYLTVLCMPGV---------------IRCPVRANPPLLFVSWTKDGKALQ 349
           + P    S S ++TV   P +               I C V +    + ++W KDG+ + 
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI- 637

Query: 350 LDKFPGWSQGTEGSLIIALGNEDAL-------------GEYSCTPYNSLGTAGPSPVTRV 396
                       GSL + + N D               G Y+C   N    A     +++
Sbjct: 638 -----------PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE--AAAVEHQSQL 684

Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG----------LQGQ 446
           +++ PP F+ +P+++     G+ +++ CSA+G P P + W K  +G          L G+
Sbjct: 685 IVRVPPKFVVQPRDQ-DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGR 742

Query: 447 AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN 497
            QV SN SL+++ + +E  G++ C  SN V     S ++Y+    P ++T+
Sbjct: 743 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITS 792



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 155/699 (22%), Positives = 272/699 (38%), Gaps = 127/699 (18%)

Query: 51   PLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVE-DQGWYECR 109
            P + I+W +   LLP       ++ R       +V  +   +L++  ++ E D+G Y C 
Sbjct: 531  PYYSIKWYKNSNLLP-------FNHR-------QVAFENNGTLKLSDVQKEVDEGEYTCN 576

Query: 110  VFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLP-HV 168
            V    Q       +    VH+TV  PP  Q  P         + V + CV     LP  +
Sbjct: 577  VLVQPQ------LSTSQSVHVTVKVPPFIQ--PFEFPRFSIGQRVFIPCVVVSGDLPITI 628

Query: 169  TWKLRGKDLGQGQGQVQVQN----GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL 224
            TW+  G+ +    G V + N     +LRI  +    +G YTC A +   +  H +QL+V 
Sbjct: 629  TWQKDGRPIPGSLG-VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687

Query: 225  GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--FHISRLQPRVRILV 282
             PP  VV P++      + V L C AE YP       F     V  F    L  R+++L 
Sbjct: 688  VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747

Query: 283  DGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVI---------------- 326
            +GSL +     +D+G Y C  SN +    S S YLTV  +P +I                
Sbjct: 748  NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK-IPAMITSYPNTTLATQGQKKE 806

Query: 327  -RCPVRANPPLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALG-----NEDALGEYS 378
              C      P++ V W K+ + +  ++ ++   ++     +I  L       ED+ G +S
Sbjct: 807  MSCTAHGEKPII-VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDS-GFFS 864

Query: 379  CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELL----------------- 421
            C   NS G      + ++ ++ PP     P E   ++V    +                 
Sbjct: 865  CHAINSYGE--DRGIIQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGY 918

Query: 422  -IPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480
             I C  + D     SW    R      Q++S + + + P +  +   +   A N + +  
Sbjct: 919  DIECKNKSD-----SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY---AKNRIGKSE 970

Query: 481  TSTNVYVLG-----TSPHVVTNVSVVALPKGANVSW---EPGFDGGYLQRFSVWYTPLAK 532
             S  + +         P    ++  ++  +   V+W   +     G ++ + + Y   + 
Sbjct: 971  PSNELTITADEAAPDGPPQEVHLEPIS-SQSIRVTWKAPKKHLQNGIIRGYQIGYREYS- 1028

Query: 533  RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLP 591
                   + +S+     +    +  L   TQY   V A N+ G+GP S EI+ +  E +P
Sbjct: 1029 TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP 1088

Query: 592  TTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQGSQG 650
            +                 PP  + A+ T P  + + W    L  + L+G +L+G +    
Sbjct: 1089 S----------------YPPENVQAIATSPESISISWS--TLSKEALNG-ILQGFRVIYW 1129

Query: 651  WEVLD------PAVAGTETELLVPGLIKDVLYEFRLVAF 683
              ++D        +  T+  L + GL K   Y  +++AF
Sbjct: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 47/179 (26%), Positives = 79/179 (44%), Gaps = 26/179 (14%)

Query: 418  RELLIPCSAQGDPPPVVSWTKVGRG------LQGQAQVDSNSSLILRPLTKEAHGHWECS 471
            +++++PC A GDP P V W K   G      + G+  + SN S I+R +  E  G++ C 
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360

Query: 472  ASN--AVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG-----GYLQRFS 524
            A+N      +  +  V V    P +  + +         +SW PG +G     GY+ ++S
Sbjct: 1361 ANNNWGSDEIILNLQVQVPPDQPRLTVSKTT---SSSITLSWLPGDNGGSSIRGYILQYS 1417

Query: 525  VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
                      +     W S  +        +  L+  T Y+F++ AQN +G G  SEI+
Sbjct: 1418 ----------EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEII 1466



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 103/443 (23%), Positives = 167/443 (37%), Gaps = 62/443 (13%)

Query: 84  RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
           R  +    +L I+ ++ ED G Y  R     ++  E   +N +   L V+ P     + P
Sbjct: 172 RFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSA--RLFVSDPAN---SAP 225

Query: 144 AVLE------VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
           ++L+          + V L C A G P P   W      L +  G+ Q     L I  + 
Sbjct: 226 SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIR 284

Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANL 257
              SG Y C+ S+  G+A    +L V  P    + P+    +    VSL+C       + 
Sbjct: 285 PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG-TEDQ 343

Query: 258 TYSWFQDNINVFHISRLQPRVRILVDG----SLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
             SW+++         L P   + + G    +L +      D G Y C      L   SA
Sbjct: 344 ELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL---SA 394

Query: 314 SAYLTVLCMPGV-------------------IRCPVRANPPLLFVSWTKDGKALQLDKFP 354
             Y+ V+   G                    + C V+   PL  ++WT D   +      
Sbjct: 395 QDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGT-PLPTITWTLDDDPILKGGSH 453

Query: 355 GWSQ--GTEGSLIIALGNEDAL----GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
             SQ   +EG+++  L    +     G Y CT  NS G        R+ ++ P +   RP
Sbjct: 454 RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVV--LYQARINVRGPASI--RP 509

Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEA- 464
            +      GR+  I C   G P   + W K    L     Q   ++N +L L  + KE  
Sbjct: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569

Query: 465 HGHWECSASNAVARVATSTNVYV 487
            G + C+      +++TS +V+V
Sbjct: 570 EGEYTCNVL-VQPQLSTSQSVHV 591



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 53/207 (25%), Positives = 80/207 (38%), Gaps = 31/207 (14%)

Query: 31  GRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYV-GRVRLQK 89
           G  G++V+L C     A   P+  I W             G   P+  P  + GR+++  
Sbjct: 701 GIYGKAVILNCS----AEGYPVPTIVWK---------FSKGAGVPQFQPIALNGRIQVLS 747

Query: 90  GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETPPAVLEV 148
             SL I+ +  ED G+Y C+V         D  A+ S  ++LTV  P      P   L  
Sbjct: 748 NGSLLIKHVVEEDSGYYLCKV-------SNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 800

Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN--------GTLRIRRVERGS 200
           Q  +   + C A G     V W+   + +     +  V           TL+I    R  
Sbjct: 801 QG-QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859

Query: 201 SGVYTCQASSTEGSATHATQLLVLGPP 227
           SG ++C A ++ G      QL V  PP
Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQEPP 886



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 10/84 (11%)

Query: 151  LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-------NGTLRIRRVERGSSGV 203
            ++ + L C A G P P V W    KD       V +        NG+  IR V+   SG 
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWM---KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356

Query: 204  YTCQASSTEGSATHATQLLVLGPP 227
            Y+C A++  GS      L V  PP
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPP 1380



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 1/64 (1%)

Query: 242  QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301
            +D+ L C A   P+     W +D+     +  +  R  I  +GS  +   + +D+G Y+C
Sbjct: 1301 KDIVLPCKAVGDPSPAV-KWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359

Query: 302  VPSN 305
            + +N
Sbjct: 1360 IANN 1363


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score =  113 bits (282), Expect = 1e-24
 Identities = 139/570 (24%), Positives = 225/570 (39%), Gaps = 67/570 (11%)

Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR--RVERGSS----GVYT 205
           +P+ L C   G+P   +TW+  G +L +      + NG+L IR  R+E G S    G Y 
Sbjct: 57  QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116

Query: 206 CQASSTEG-SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
           C A +  G   +   ++         V P+ +           C     P  L  +W ++
Sbjct: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL-ITWEKN 175

Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV----- 319
            +    I     R  +L  G L++   + +D G + CV SN      S  A LTV     
Sbjct: 176 RV---PIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGS 232

Query: 320 ------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQGT 360
                             +    V+ C    NP  + VSW++ DG+ + ++   G     
Sbjct: 233 GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRLDGRPIGVE---GIQVLG 288

Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
            G+LII+       G Y C           +   R++++AP  F++ P +   +  G   
Sbjct: 289 TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP-QSISRPAGTTA 347

Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVA 477
           +  C AQG+PPP V+W K G+ L     V   ++NS+L +  +  E    ++C A N+  
Sbjct: 348 MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAG 407

Query: 478 RVATSTNVYVLGTS--PHVVTNVSVVALPK-GANVSW-EPGFDGGYLQRFSVWYTPLAKR 533
               S  + VL     P    NV  V++      VSW EP  +   +  + +     A  
Sbjct: 408 SSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADP 467

Query: 534 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 593
           P+  + +    AV       LV  L+P T Y F + A    G+   S         +PT 
Sbjct: 468 PELEYQE----AVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS---------VPTL 514

Query: 594 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV 653
            +  G  P   PPPLS     V V     + L W+P   + +   G+ L  R  S+    
Sbjct: 515 ASTLGEAPA--PPPLS-----VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567

Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF 683
               + GT +   +  L    +YE +L+A+
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAY 597



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 84/282 (29%), Positives = 120/282 (42%), Gaps = 29/282 (10%)

Query: 77  IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
           ID D      L KG  LQI GLR ED G + C    +  +I     ++G+   LTV+   
Sbjct: 179 IDTDNERYTLLPKGV-LQITGLRAEDGGIFHC----VASNIASIRISHGA--RLTVSGSG 231

Query: 137 QFQETPPAVLEVQELEPVT------LRCVARGSPLPHVTW-KLRGKDLGQGQGQVQVQNG 189
                 PA+L   E   +T      L CVA G+P P V+W +L G+ +G  +G   +  G
Sbjct: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGV-EGIQVLGTG 290

Query: 190 TLRIRRVERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
            L I  V    SGVY C A+   T    T   +L+V  P   V  P++ +  A       
Sbjct: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350

Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNG 306
           C A+  P     +W ++      +      VR+  + S L +    P+D   Y CV  N 
Sbjct: 351 CQAQGEPPP-HVTWLKNG----QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405

Query: 307 LLHPPSASAYLTVLCMPGVIRCP-----VRANPPLLFVSWTK 343
                 ASA LTVL   G+   P     V  +   + VSW++
Sbjct: 406 -AGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSE 446



 Score = 33.9 bits (76), Expect = 0.93
 Identities = 26/100 (26%), Positives = 44/100 (44%), Gaps = 9/100 (9%)

Query: 390 PSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQA 447
           P+P   +   A  AF   P ++     G+ +++ C  +G PP  ++W K G  L     +
Sbjct: 30  PAPSEGLGHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS 88

Query: 448 QVDSNSSLILRPLTKEA------HGHWECSASNAVARVAT 481
            + +N SL++R    E        G +EC A N    V +
Sbjct: 89  TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVS 128


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
           [Homo sapiens]
          Length = 1250

 Score =  111 bits (277), Expect = 5e-24
 Identities = 142/582 (24%), Positives = 225/582 (38%), Gaps = 79/582 (13%)

Query: 160 ARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR--VERGSS-----------GVYTC 206
           A   P   VTW   G  L +      + NG+L + +     GS            G Y+C
Sbjct: 62  AAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSC 121

Query: 207 QASSTEGSATHATQLLVLGPPV-IVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
            A    G     T ++ L       + P++ TV  +      CH E  PA +  +W +D 
Sbjct: 122 LAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPII-TWEKDQ 180

Query: 266 INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYL-------- 317
           + +      +PR+ +L +G L++L  Q  DAG Y CV +N      S  A L        
Sbjct: 181 VTLPE----EPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSL 236

Query: 318 -----------------TVLCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQG 359
                            TV+    V+   V +  P  FVSW + DGK +  D        
Sbjct: 237 ASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRT- 295

Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
              +L+IA       G Y C           +    + + A PA  + P E   +     
Sbjct: 296 ---NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAP-EALSRTRAST 351

Query: 420 LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNA- 475
               C A G+P P + W   G  L+   +V       SL++  +  +  G+++C A N+ 
Sbjct: 352 ARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSA 411

Query: 476 -VARVATSTNVYVLGTSPHVVTNVSVVALPKGAN-VSWE-PGFDGGYLQRFSVWYTPLAK 532
            +A  A S  V V    P   T V+   L   A  V+WE P      +  FS+ Y   A+
Sbjct: 412 GMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQK-AR 470

Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
             D + + +   AV      L V  L+P+T Y+F V+A ++LG+   S            
Sbjct: 471 GMDNVEYQF---AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTS------------ 515

Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP--PELVPKRLDGYVLEGRQGSQG 650
               P L  T    P + P+  ++   P  + + W P  P L   ++  Y +E   G + 
Sbjct: 516 ---TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED 572

Query: 651 WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPS 692
            ++    V G ET+L++  L  + +Y  R+ A   +    PS
Sbjct: 573 -QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS 613



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 145/606 (23%), Positives = 229/606 (37%), Gaps = 99/606 (16%)

Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
           P    V+E       C   G P P +TW+     L +    + + NG L+I  V+   +G
Sbjct: 149 PESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAG 208

Query: 203 VYTCQASSTEGSATHATQLLVLG-------------PPVIVVPPKNSTVNASQDVSLACH 249
            Y C A  T  +  H +Q  +L                VIV  P+N+TV + Q V + C 
Sbjct: 209 PYRCVA--TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266

Query: 250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLH 309
           A A P     SW + +        +   V +L   +L +   QP  +G Y C  +     
Sbjct: 267 ASADPTPFV-SWVRQD-----GKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320

Query: 310 P-PSASAYLTVLCMPGVIRCP-----VRAN----------PPLLFVSWTKDGKALQLDKF 353
              +A+A L VL  P + + P      RA+           P   + W  +G  L+ +  
Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380

Query: 354 PGWSQGTEGSLIIA-LGNEDALGEYSCTPYNSLGTA----------------GPSPVTRV 396
               QG  GSL+I  +G +DA G Y C   NS G A                 P+ VT  
Sbjct: 381 VK-VQGGGGSLVITQIGLQDA-GYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTAT 438

Query: 397 LLKAPPAFI--ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454
            L +    +  ERP+    Q +G  L    +   D             ++ Q  V+++++
Sbjct: 439 PLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMD------------NVEYQFAVNNDTT 486

Query: 455 -LILRPLTKEAHGHWECSASN--AVARVATSTNVYVLGTSPHVVTNVSVVA-LPKGANVS 510
            L +R L       +   A +    +R +T   V+ L   P     +S+ +  P    V+
Sbjct: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546

Query: 511 W---EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFS 567
           W    P    G + ++ + Y     + D++     S  V      L++  LQP+  Y+  
Sbjct: 547 WLPLPPSLSNGQVVKYKIEYG--LGKEDQI----FSTEVRGNETQLMLNSLQPNKVYRVR 600

Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP------R 621
           + A    G G  S+ +      +      P   P E+         +V+ + P       
Sbjct: 601 ISAGTAAGFGAPSQWMHHRTPSMHNQSHVP-FAPAELKVQAKMESLVVSWQPPPHPTQIS 659

Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV----LDPAVAGTETELLVPGLIKDVLYE 677
           G  L+W       +  +G  L G +G Q W+V    L   V   E   LVPG     LYE
Sbjct: 660 GYKLYWREVG-AEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR----LYE 714

Query: 678 FRLVAF 683
            +LVAF
Sbjct: 715 VKLVAF 720



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 101/401 (25%), Positives = 144/401 (35%), Gaps = 85/401 (21%)

Query: 553  LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612
            +L+ GL+P T+Y+F+V +      GPF  +V  +     T P  P  PP+++   LSP  
Sbjct: 808  ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS-----TLPDRPSTPPSDL--RLSP-- 858

Query: 613  GLVAVRTPRGVLLHWDPP-----ELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLV 667
                  TP  V LHW PP     E+V + L  Y     Q    W +L     G      V
Sbjct: 859  -----LTPSTVRLHWCPPTEPNGEIV-EYLILYSSNHTQPEHQWTLL--TTQGNIFSAEV 910

Query: 668  PGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727
             GL  D  Y F++ A         S   +V T        + +L   L    + G++ GV
Sbjct: 911  HGLESDTRYFFKMGARTEVGPGPFSRLQDVIT-------LQEKLSDSLDMHSVTGIIVGV 963

Query: 728  CFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPT-GKSAAPSALGSGSPDSVA 786
            C LG+         CLL    A  RR       P L  + T G  A  S    G P   A
Sbjct: 964  C-LGLL--------CLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPA 1014

Query: 787  KLKLQG---------SPVPS----------------------LRQSLLWGDPAG------ 809
              +L+          SP PS                       ++ + W  P+G      
Sbjct: 1015 AHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGS 1074

Query: 810  -----TPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRL 864
                  P   P P  +R  LP      G     ++   V    + +GR+++ P    Q  
Sbjct: 1075 WAGCELPQAGPRPALTRALLP----PAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVE 1130

Query: 865  ARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPG 905
            A     S  S S     L ++D+ P  P P   P  + G G
Sbjct: 1131 AEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVG 1171



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 123/547 (22%), Positives = 200/547 (36%), Gaps = 98/547 (17%)

Query: 224 LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD 283
           +GP  +++ P+ + V    + SL   A   P  +T  W +D   +     L     +L +
Sbjct: 40  VGPLQVILGPEQAAV---LNCSLGAAAAGPPTRVT--WSKDGDTLLEHDHLH----LLPN 90

Query: 284 GSLRL---LATQPDDA----------GCYTCVPSN--GLLHPPSASAYLTVLC------- 321
           GSL L   LA    D           G Y+C+     G+L   +A   L  L        
Sbjct: 91  GSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPE 150

Query: 322 -----MPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDAL 374
                  G  R  C +   P  + ++W KD   + L + P       G L I    E   
Sbjct: 151 SQTVEENGTARFECHIEGLPAPI-ITWEKD--QVTLPEEPRLIVLPNGVLQILDVQESDA 207

Query: 375 GEYSCTPYNSL---------------GTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
           G Y C   NS                G+   +    V++ A P       E      G+ 
Sbjct: 208 GPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAP-------ENTTVVSGQS 260

Query: 420 LLIPCSAQGDPPPVVSWTKV-GRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478
           +++ C A  DP P VSW +  G+ +     V   ++L++        G + C A+    R
Sbjct: 261 VVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320

Query: 479 -VATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRM 537
             AT+     +  +P +      ++  + +   +     G         +     RP+  
Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380

Query: 538 HHDWVSLAVPVGAAHLLVP--GLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEGLPTTP 594
                 + V  G   L++   GLQ    YQ   +A+N  G     + + +   EGLP+ P
Sbjct: 381 ------VKVQGGGGSLVITQIGLQDAGYYQ--CVAENSAGMACAAASLAVVVREGLPSAP 432

Query: 595 AAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVL 654
                 P                 +   VL+ W+ PE+  +++ G+ L   Q ++G + +
Sbjct: 433 TRVTATPL----------------SSSAVLVAWERPEMHSEQIIGFSLH-YQKARGMDNV 475

Query: 655 DP--AVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRT-QL 711
           +   AV    TEL V  L  +  YEF +VA++    S  S  A V T  L+  PS   QL
Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHT--LDDVPSAAPQL 533

Query: 712 PGLLPQP 718
               P P
Sbjct: 534 SLSSPNP 540



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%)

Query: 504 PKGANVSWEPGFD-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562
           P    + W P  +  G +  + + Y+    +P+   H W  L          V GL+  T
Sbjct: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPE---HQWTLLTTQGNIFSAEVHGLESDT 917

Query: 563 QYQFSVLAQNKLGSGPFSEI 582
           +Y F + A+ ++G GPFS +
Sbjct: 918 RYFFKMGARTEVGPGPFSRL 937


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  110 bits (276), Expect = 6e-24
 Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  + C   RG P P ++WK  G  L     ++ ++ G L I   
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G Y C  ++  G   +   +L VL  P  V  P N  V         C A   P 
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             T  W +D+  +      + R  I  D +L++      D G YTCV  N ++    ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304

Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355
            LTV   P  +                +C    NP P +F  W ++G    L  +     
Sbjct: 305 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 362

Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409
              +S    G L I       +G Y C   N  G   T     VT V+   PP  I +  
Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422

Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465
                 V    ++ C A G P P + W K G  +  Q     Q++ N  L +R       
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481

Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510
           G + C AS        S  + V            T P+++   S  + P+  +VS     
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 539

Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564
             W+P  + G         TP +   +   H     W ++A  V      + GL+P+  Y
Sbjct: 540 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 591

Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620
            F V A N  G    S+I  S P +     P + G+   ++   L     ++ +  P   
Sbjct: 592 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 647

Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670
               + +HW   +   + + GY +  R      G   W   EV  PA    +  +++P L
Sbjct: 648 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 702

Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730
            K V YE +   F   F    S      T  LE  PS        PQ V      G    
Sbjct: 703 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 751

Query: 731 GVAVLVS 737
           G A+LVS
Sbjct: 752 GTAILVS 758



 Score =  110 bits (274), Expect = 1e-23
 Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%)

Query: 19  DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
           D R  P  V V    GE  V+ C   PP G P    I W + G            SP  D
Sbjct: 132 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 174

Query: 79  PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
            D    +R   G  L I   R  D G Y C     V   +  + E          LTV  
Sbjct: 175 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 221

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
            P F + P + L V   +    +C ARG P+P V W+    +L + + +++  + TL+IR
Sbjct: 222 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 279

Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
           +V  G  G YTC A +  G A  +  L V  PP  VV P++  V   + V+  C A   P
Sbjct: 280 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 339

Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
               + W ++       S   P    R  +   G L +   Q  D G Y C   N +   
Sbjct: 340 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 397

Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349
               AYL V  +     P VIR                  V    P+  + W KDG  L 
Sbjct: 398 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 456

Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409
             +     Q   G L I        G Y+C      G A  S    V     P    RP 
Sbjct: 457 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 516

Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466
           +          LIP +     P V   ++    L  Q  ++S    +S I+   +  +  
Sbjct: 517 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 566

Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494
            W+  A N     +                + N Y                VL TS  V 
Sbjct: 567 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 626

Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539
                         + N +V++      V W       Y+Q + + Y     RP   +H 
Sbjct: 627 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 680

Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596
             DW+   V   A + +++P L+    Y+           G  SEI  +      T   A
Sbjct: 681 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 735

Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653
           P  PP  +    +   G         +L+ W PP       +G V E +    G E    
Sbjct: 736 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 786

Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707
           ++  V G+   +++P L+  + Y   + A   AGS V        +   G  V P     
Sbjct: 787 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 846

Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766
              Q+  ++ QP     +G  C++ + ++ SI       +R         +R+ P   F+
Sbjct: 847 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 905

Query: 767 PT 768
           PT
Sbjct: 906 PT 907



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  ++ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 28  PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       GVY C A +  G A   +A+  + +        P +  V   +
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              + C         T SW +D      +     R+ I   G L +  T+  DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202

Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346
            +N +    S  A LTVL  P  +                +C  R + P+  V W KD  
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 261

Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406
            L   ++      T     +  G+   +G Y+C   N +G A  S    V  + PP F+ 
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 316

Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456
           +P+++    +GR +   C A G+P P + W + G               +  V     L 
Sbjct: 317 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375

Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
           +  + +   G++ C   N    + T   + V      V+ +     + +G  V+     D
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 430

Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569
           G ++       +P+     R   D V ++        L  G+    +Y       +++ +
Sbjct: 431 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 487

Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
           A    G   +S  +     G+P  P  P   P  IP   S P   V   +   V L W P
Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 544

Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687
                     Y++E    + G  W+ +   V  TET   + GL  + +Y F + A     
Sbjct: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 602

Query: 688 VSDPSNTAN 696
           +SDPS  ++
Sbjct: 603 ISDPSQISD 611



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)

Query: 768  TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
            TG S   S  GS +  S    K   +P    +  + W D    P  HP P S+     + 
Sbjct: 1107 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1166

Query: 827  -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
                   E  C  P  R  +        E    E     TP  R A S   + S      
Sbjct: 1167 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1221

Query: 874  -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
                 SP    QP+   C E+             PV+PPP  PP P+  P     Y+S P
Sbjct: 1222 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1278

Query: 915  FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
               +M  D D P  EE         M TRR      LR  E  P S    L  +V G+
Sbjct: 1279 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1330


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  110 bits (276), Expect = 6e-24
 Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  + C   RG P P ++WK  G  L     ++ ++ G L I   
Sbjct: 172 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 230

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G Y C  ++  G   +   +L VL  P  V  P N  V         C A   P 
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             T  W +D+  +      + R  I  D +L++      D G YTCV  N ++    ASA
Sbjct: 291 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 343

Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355
            LTV   P  +                +C    NP P +F  W ++G    L  +     
Sbjct: 344 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 401

Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409
              +S    G L I       +G Y C   N  G   T     VT V+   PP  I +  
Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461

Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465
                 V    ++ C A G P P + W K G  +  Q     Q++ N  L +R       
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520

Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510
           G + C AS        S  + V            T P+++   S  + P+  +VS     
Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 578

Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564
             W+P  + G         TP +   +   H     W ++A  V      + GL+P+  Y
Sbjct: 579 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 630

Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620
            F V A N  G    S+I  S P +     P + G+   ++   L     ++ +  P   
Sbjct: 631 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 686

Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670
               + +HW   +   + + GY +  R      G   W   EV  PA    +  +++P L
Sbjct: 687 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 741

Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730
            K V YE +   F   F    S      T  LE  PS        PQ V      G    
Sbjct: 742 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 790

Query: 731 GVAVLVS 737
           G A+LVS
Sbjct: 791 GTAILVS 797



 Score =  110 bits (274), Expect = 1e-23
 Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%)

Query: 19  DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
           D R  P  V V    GE  V+ C   PP G P    I W + G            SP  D
Sbjct: 171 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 213

Query: 79  PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
            D    +R   G  L I   R  D G Y C     V   +  + E          LTV  
Sbjct: 214 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 260

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
            P F + P + L V   +    +C ARG P+P V W+    +L + + +++  + TL+IR
Sbjct: 261 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 318

Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
           +V  G  G YTC A +  G A  +  L V  PP  VV P++  V   + V+  C A   P
Sbjct: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 378

Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
               + W ++       S   P    R  +   G L +   Q  D G Y C   N +   
Sbjct: 379 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 436

Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349
               AYL V  +     P VIR                  V    P+  + W KDG  L 
Sbjct: 437 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 495

Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409
             +     Q   G L I        G Y+C      G A  S    V     P    RP 
Sbjct: 496 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 555

Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466
           +          LIP +     P V   ++    L  Q  ++S    +S I+   +  +  
Sbjct: 556 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 605

Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494
            W+  A N     +                + N Y                VL TS  V 
Sbjct: 606 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 665

Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539
                         + N +V++      V W       Y+Q + + Y     RP   +H 
Sbjct: 666 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 719

Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596
             DW+   V   A + +++P L+    Y+           G  SEI  +      T   A
Sbjct: 720 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 774

Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653
           P  PP  +    +   G         +L+ W PP       +G V E +    G E    
Sbjct: 775 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 825

Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707
           ++  V G+   +++P L+  + Y   + A   AGS V        +   G  V P     
Sbjct: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 885

Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766
              Q+  ++ QP     +G  C++ + ++ SI       +R         +R+ P   F+
Sbjct: 886 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 944

Query: 767 PT 768
           PT
Sbjct: 945 PT 946



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  ++ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 67  PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       GVY C A +  G A   +A+  + +        P +  V   +
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              + C         T SW +D      +     R+ I   G L +  T+  DAG Y CV
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 241

Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346
            +N +    S  A LTVL  P  +                +C  R + P+  V W KD  
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 300

Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406
            L   ++      T     +  G+   +G Y+C   N +G A  S    V  + PP F+ 
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 355

Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456
           +P+++    +GR +   C A G+P P + W + G               +  V     L 
Sbjct: 356 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414

Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
           +  + +   G++ C   N    + T   + V      V+ +     + +G  V+     D
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 469

Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569
           G ++       +P+     R   D V ++        L  G+    +Y       +++ +
Sbjct: 470 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 526

Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
           A    G   +S  +     G+P  P  P   P  IP   S P   V   +   V L W P
Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 583

Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687
                     Y++E    + G  W+ +   V  TET   + GL  + +Y F + A     
Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 641

Query: 688 VSDPSNTAN 696
           +SDPS  ++
Sbjct: 642 ISDPSQISD 650



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)

Query: 768  TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
            TG S   S  GS +  S    K   +P    +  + W D    P  HP P S+     + 
Sbjct: 1146 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1205

Query: 827  -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
                   E  C  P  R  +        E    E     TP  R A S   + S      
Sbjct: 1206 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260

Query: 874  -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
                 SP    QP+   C E+             PV+PPP  PP P+  P     Y+S P
Sbjct: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1317

Query: 915  FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
               +M  D D P  EE         M TRR      LR  E  P S    L  +V G+
Sbjct: 1318 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1369


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  110 bits (276), Expect = 6e-24
 Identities = 157/645 (24%), Positives = 247/645 (38%), Gaps = 81/645 (12%)

Query: 23  KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75
           K ++  +  ++G+S+VL C   PP G PP  +I W+   F  LP        +   LY  
Sbjct: 143 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199

Query: 76  RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123
            + P     DY+   R     ++Q        +     +V  +D+       ++ + +F 
Sbjct: 200 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 252

Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
                  +   PP F          +EL    ++L C+A G P P + W      L + +
Sbjct: 253 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 309

Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241
              +    TL+I  V    SG Y C A +  G+  H   + V   P  +  P+N  ++  
Sbjct: 310 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 369

Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300
           +D +L C A   P     SW  + + +  I+   P  +I  DG   + +  Q   +  Y 
Sbjct: 370 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 425

Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341
           C  SN  G L    A+A++ VL  P  I  P      V AN P L            + W
Sbjct: 426 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 482

Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
            K   G AL  D +     GT   L I +  +D+ G Y+C   N LG A       + +K
Sbjct: 483 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 537

Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456
            P   +++P+    Q  G  +   C  + D      V W K  R L    +       L+
Sbjct: 538 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 596

Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
           +  ++ +  G + C A+  +  V+ S  + V+              L K   +SW PG D
Sbjct: 597 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDD 656

Query: 517 GGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
               + +F + Y     +P   HH    ++     A L    L P+  Y F V+A N +G
Sbjct: 657 NNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYSFRVMAVNSIG 712

Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
               SE    A E   T  + P   PT +    S P  LV    P
Sbjct: 713 KSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 753



 Score =  106 bits (264), Expect = 1e-22
 Identities = 188/807 (23%), Positives = 295/807 (36%), Gaps = 175/807 (21%)

Query: 43   LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102
            L+  A   P   I WL  G  +PI I     S +ID D +    +Q+ +S          
Sbjct: 374  LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 423

Query: 103  QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162
               Y+C       ++  + F N       +  PP+       + +V    P  L C   G
Sbjct: 424  ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 474

Query: 163  SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221
            SPLP + W    K     +   V  +NGTL I   ++ S+G YTC A +  G A +   L
Sbjct: 475  SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534

Query: 222  LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280
             +  P  IV  P+ + V     VS  C  +  +  +LT  W +DN        L    R 
Sbjct: 535  EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 588

Query: 281  LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPL--- 336
             VD    ++A    DD+G YTCV +N  L   SASA L+V+ +P         NPP    
Sbjct: 589  TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVDVP---------NPPFDLE 638

Query: 337  --------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDALGE 376
                    + +SWT  D     + KF          PG W   TE S            +
Sbjct: 639  LTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTTAQ 692

Query: 377  YSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA 426
               +PY          NS+G + PS  +               E+Y  +       P + 
Sbjct: 693  LKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPTAV 737

Query: 427  QG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSASNA 475
            +G   +P   V++W  +      G GLQ +               K+    W     +N 
Sbjct: 738  EGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVANV 787

Query: 476  VARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA--------------N 508
               + + T  +V                 P VV   S   LP  A               
Sbjct: 788  SKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAE 847

Query: 509  VSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQ 563
            V W+P       G+LQ + ++Y  T  + + +R H +   L       H ++PGL+P + 
Sbjct: 848  VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907

Query: 564  YQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRG 622
            Y  +V   N  G GP S + V + PEG+P+ P++  +    + P L              
Sbjct: 908  YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD------------S 951

Query: 623  VLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYEFR 679
            + L WDPP      L  Y L+ +  +   E   ++D  +   +T   +  L     Y+F 
Sbjct: 952  LTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFY 1011

Query: 680  LVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSIL 739
              A   S  S    T    T+  E   SR      +        +G +C + + +L+ +L
Sbjct: 1012 FYA-QTSAGSGSQITEEAVTTVDEAMASRQ-----VDIATQGWFIGLMCAVALLILI-LL 1064

Query: 740  AGCLLNRRRAAR---RRRKRLRQDPPL 763
              C + R +  +   + ++    DP +
Sbjct: 1065 IVCFIRRNKGGKYPVKEKEDAHADPEI 1091



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 94/428 (21%), Positives = 157/428 (36%), Gaps = 66/428 (15%)

Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
           V L +  PP   +  P    +   E + ++C A+G P P  +W   G      +  +   
Sbjct: 32  VPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 91

Query: 188 ---NGTLRIRRVERGSS----GVYTCQASSTEGSAT------------------------ 216
               GTL I  +  G +    GVY C A +  G+A                         
Sbjct: 92  KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL 151

Query: 217 HATQLLVL--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------L 257
            + Q LVL   PP+ + PP      NS   +  S+ VS   + + Y +N          +
Sbjct: 152 QSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 211

Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPS 312
            Y+ F     +     +  +V I VD     +A    D   Y        P   L    +
Sbjct: 212 CYARFNHTQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 270

Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372
           AS    +      + C +    P   + W K+   L  ++     +  E +L I   +E 
Sbjct: 271 ASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEA 327

Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432
             G Y C   N+LG    +   RV  KA P +I  P +      G +  + C A G+P P
Sbjct: 328 DSGNYQCIAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKP 384

Query: 433 VVSWTKVGRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVL 488
            +SW   G  ++      ++     ++I   + + +   ++C+ASN    +  +  V VL
Sbjct: 385 RISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL 444

Query: 489 GTSPHVVT 496
              P ++T
Sbjct: 445 AEPPRILT 452


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  110 bits (275), Expect = 8e-24
 Identities = 159/655 (24%), Positives = 250/655 (38%), Gaps = 91/655 (13%)

Query: 23  KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75
           K ++  +  ++G+S+VL C   PP G PP  +I W+   F  LP        +   LY  
Sbjct: 149 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 205

Query: 76  RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123
            + P     DY+   R     ++Q        +     +V  +D+       ++ + +F 
Sbjct: 206 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 258

Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
                  +   PP F          +EL    ++L C+A G P P + W      L + +
Sbjct: 259 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 315

Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241
              +    TL+I  V    SG Y C A +  G+  H   + V   P  +  P+N  ++  
Sbjct: 316 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 375

Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300
           +D +L C A   P     SW  + + +  I+   P  +I  DG   + +  Q   +  Y 
Sbjct: 376 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 431

Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341
           C  SN  G L    A+A++ VL  P  I  P      V AN P L            + W
Sbjct: 432 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 488

Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
            K   G AL  D +     GT   L I +  +D+ G Y+C   N LG A       + +K
Sbjct: 489 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 543

Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456
            P   +++P+    Q  G  +   C  + D      V W K  R L    +       L+
Sbjct: 544 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 602

Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVV----------ALPKG 506
           +  ++ +  G + C A+  +  V+ S  + V+  +P       V            L K 
Sbjct: 603 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKS 662

Query: 507 ANVSWEPGFDGGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQ 565
             +SW PG D    + +F + Y     +P   HH    ++     A L    L P+  Y 
Sbjct: 663 VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYS 718

Query: 566 FSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
           F V+A N +G    SE    A E   T  + P   PT +    S P  LV    P
Sbjct: 719 FRVMAVNSIGKSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 769



 Score =  105 bits (262), Expect = 3e-22
 Identities = 185/770 (24%), Positives = 279/770 (36%), Gaps = 168/770 (21%)

Query: 43   LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102
            L+  A   P   I WL  G  +PI I     S +ID D +    +Q+ +S          
Sbjct: 380  LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 429

Query: 103  QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162
               Y+C       ++  + F N       +  PP+       + +V    P  L C   G
Sbjct: 430  ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 480

Query: 163  SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221
            SPLP + W    K     +   V  +NGTL I   ++ S+G YTC A +  G A +   L
Sbjct: 481  SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 540

Query: 222  LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280
             +  P  IV  P+ + V     VS  C  +  +  +LT  W +DN        L    R 
Sbjct: 541  EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 594

Query: 281  LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR--ANPPL- 336
             VD    ++A    DD+G YTCV +N  L   SASA L+V+  P     PV    NPP  
Sbjct: 595  TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVA-PTPTPAPVYDVPNPPFD 652

Query: 337  ----------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDAL 374
                      + +SWT  D     + KF          PG W   TE S           
Sbjct: 653  LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTT 706

Query: 375  GEYSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
             +   +PY          NS+G + PS  +               E+Y  +       P 
Sbjct: 707  AQLKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPT 751

Query: 425  SAQG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSAS 473
            + +G   +P   V++W  +      G GLQ +               K+    W     +
Sbjct: 752  AVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVA 801

Query: 474  NAVARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA------------- 507
            N    + + T  +V                 P VV   S   LP  A             
Sbjct: 802  NVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTL 861

Query: 508  -NVSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561
              V W+P       G+LQ + ++Y  T  + + +R H +   L       H ++PGL+P 
Sbjct: 862  AEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPF 921

Query: 562  TQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
            + Y  +V   N  G GP S + V + PEG+P+ P++  +    + P L            
Sbjct: 922  SHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD----------- 966

Query: 621  RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYE 677
              + L WDPP      L  Y L+ +  +   E   ++D  +   +T   +  L     Y+
Sbjct: 967  -SLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYK 1025

Query: 678  FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727
            F   A           +A   +   E   +     G+LP  V AG V  V
Sbjct: 1026 FYFYA---------QTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAV 1066



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 92/421 (21%), Positives = 154/421 (36%), Gaps = 66/421 (15%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ---NGTL 191
           PP   +  P    +   E + ++C A+G P P  +W   G      +  +       GTL
Sbjct: 45  PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104

Query: 192 RIRRVERGSS----GVYTCQASSTEGSAT------------------------HATQLLV 223
            I  +  G +    GVY C A +  G+A                          + Q LV
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164

Query: 224 L--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------LTYSWFQD 264
           L   PP+ + PP      NS   +  S+ VS   + + Y +N          + Y+ F  
Sbjct: 165 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNH 224

Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPSASAYLTV 319
              +     +  +V I VD     +A    D   Y        P   L    +AS    +
Sbjct: 225 TQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 283

Query: 320 LCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSC 379
                 + C +    P   + W K+   L  ++     +  E +L I   +E   G Y C
Sbjct: 284 RGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEADSGNYQC 340

Query: 380 TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKV 439
              N+LG    +   RV  KA P +I  P +      G +  + C A G+P P +SW   
Sbjct: 341 IAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKPRISWLTN 397

Query: 440 GRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495
           G  ++      ++     ++I   + + +   ++C+ASN    +  +  V VL   P ++
Sbjct: 398 GVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRIL 457

Query: 496 T 496
           T
Sbjct: 458 T 458



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 18/103 (17%)

Query: 398 LKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLIL 457
           L  PP   ++  ++Y  +    ++I C A+G PPP  SWT+ G        +D +  + +
Sbjct: 42  LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGT----HFDIDKDPLVTM 97

Query: 458 RPLT-------------KEAHGHWECSASNAVARVATSTNVYV 487
           +P T             +   G ++C+A N     A S N+ V
Sbjct: 98  KPGTGTLIINIMSEGKAETYEGVYQCTARNE-RGAAVSNNIVV 139


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  108 bits (270), Expect = 3e-23
 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  + C   RG P P ++WK  G  L     ++ ++ G L I   
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G Y C  ++  G   +   +L VL  P  V  P N  V         C A   P 
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             T  W +D+  +      + R  I  D +L++      D G YTCV  N ++    ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304

Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
            LTV                   L      +C    NP P +F  W ++G    L  +  
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362

Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
                 +S    G L I       +G Y C   N  G   T     VT V+   PP  I 
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
           +        V    ++ C A G P P + W K G  +  Q    +   N  L +R     
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
             G + C AS        S  + V            T P+++   S  + P+  +V    
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540

Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
              SW+P  + G         TP +   +   H     W ++A  V      + GL+P+ 
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592

Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
            Y F V A N  G    S+I  S P +     P + G+   ++   L     ++ +  P 
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648

Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
                 + +HW   +   + + GY +  R      G   W   EV  PA    +  +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703

Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
            L K V YE +   F   F    S      T  LE  PS        PQ V      G  
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753

Query: 729 FLGVAVLVS 737
             G A+LVS
Sbjct: 754 -NGTAILVS 761



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  ++ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 28  PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       GVY C A +  G A   +A+  + +        P +  V   +
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              + C         T SW +D      +     R+ I   G L +  T+  DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202

Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
            +N +    S  A LTVL  P  ++                C  R +P +  V W KD  
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261

Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
            L   ++      T     +  G+   +G Y+C   N +G A  S    V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
            +P+++    +GR +   C A G+P P + W + G               +  V     L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377

Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
            +  + +   G++ C   N    + T   + V      V+ +     + +G  V+     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432

Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
           DG ++       +P+     R   D V ++        L  G+    +Y       +++ 
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489

Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
           +A    G   +S  +     G+P  P  P   P  IP   S P   V   +   V L W 
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546

Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
           P          Y++E    + G  W+ +   V  TET   + GL  + +Y F + A    
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604

Query: 687 FVSDPSNTAN 696
            +SDPS  ++
Sbjct: 605 GISDPSQISD 614



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           G +V   C+    A   P   I W R G    +F     Y P   P    R  + +   L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377

Query: 94  QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
            I  ++  D G+Y C+   +   I    +   + V    + PP      P    V     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435

Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
             L CVA GSP+P + W+  G  +     ++ Q++NG L+IR  + G +G YTC AS+  
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
           G AT +  + V    V V PP+ +  N                N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)

Query: 768  TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
            TG S   S  GS +  S    K   +P    +  + W D    P  HP P S+     + 
Sbjct: 1046 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1105

Query: 827  -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
                   E  C  P  R  +        E    E     TP  R A S   + S      
Sbjct: 1106 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1160

Query: 874  -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
                 SP    QP+   C E+             PV+PPP  PP P+  P     Y+S P
Sbjct: 1161 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1217

Query: 915  FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
               +M  D D P  EE         M TRR      LR  E  P S    L  +V G+
Sbjct: 1218 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1269


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  108 bits (270), Expect = 3e-23
 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  + C   RG P P ++WK  G  L     ++ ++ G L I   
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G Y C  ++  G   +   +L VL  P  V  P N  V         C A   P 
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             T  W +D+  +      + R  I  D +L++      D G YTCV  N ++    ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304

Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
            LTV                   L      +C    NP P +F  W ++G    L  +  
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362

Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
                 +S    G L I       +G Y C   N  G   T     VT V+   PP  I 
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
           +        V    ++ C A G P P + W K G  +  Q    +   N  L +R     
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
             G + C AS        S  + V            T P+++   S  + P+  +V    
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540

Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
              SW+P  + G         TP +   +   H     W ++A  V      + GL+P+ 
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592

Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
            Y F V A N  G    S+I  S P +     P + G+   ++   L     ++ +  P 
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648

Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
                 + +HW   +   + + GY +  R      G   W   EV  PA    +  +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703

Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
            L K V YE +   F   F    S      T  LE  PS        PQ V      G  
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753

Query: 729 FLGVAVLVS 737
             G A+LVS
Sbjct: 754 -NGTAILVS 761



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  ++ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 28  PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       GVY C A +  G A   +A+  + +        P +  V   +
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              + C         T SW +D      +     R+ I   G L +  T+  DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202

Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
            +N +    S  A LTVL  P  ++                C  R +P +  V W KD  
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261

Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
            L   ++      T     +  G+   +G Y+C   N +G A  S    V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
            +P+++    +GR +   C A G+P P + W + G               +  V     L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377

Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
            +  + +   G++ C   N    + T   + V      V+ +     + +G  V+     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432

Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
           DG ++       +P+     R   D V ++        L  G+    +Y       +++ 
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489

Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
           +A    G   +S  +     G+P  P  P   P  IP   S P   V   +   V L W 
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546

Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
           P          Y++E    + G  W+ +   V  TET   + GL  + +Y F + A    
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604

Query: 687 FVSDPSNTAN 696
            +SDPS  ++
Sbjct: 605 GISDPSQISD 614



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           G +V   C+    A   P   I W R G    +F     Y P   P    R  + +   L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377

Query: 94  QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
            I  ++  D G+Y C+   +   I    +   + V    + PP      P    V     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435

Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
             L CVA GSP+P + W+  G  +     ++ Q++NG L+IR  + G +G YTC AS+  
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
           G AT +  + V    V V PP+ +  N                N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)

Query: 768  TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
            TG S   S  GS +  S    K   +P    +  + W D    P  HP P S+     + 
Sbjct: 1101 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1160

Query: 827  -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
                   E  C  P  R  +        E    E     TP  R A S   + S      
Sbjct: 1161 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1215

Query: 874  -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
                 SP    QP+   C E+             PV+PPP  PP P+  P     Y+S P
Sbjct: 1216 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1272

Query: 915  FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
               +M  D D P  EE         M TRR      LR  E  P S    L  +V G+
Sbjct: 1273 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1324


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  108 bits (270), Expect = 3e-23
 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)

Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
           F++ P  V+ V   EP  + C   RG P P ++WK  G  L     ++ ++ G L I   
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191

Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            +  +G Y C  ++  G   +   +L VL  P  V  P N  V         C A   P 
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
             T  W +D+  +      + R  I  D +L++      D G YTCV  N ++    ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304

Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
            LTV                   L      +C    NP P +F  W ++G    L  +  
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362

Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
                 +S    G L I       +G Y C   N  G   T     VT V+   PP  I 
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
           +        V    ++ C A G P P + W K G  +  Q    +   N  L +R     
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
             G + C AS        S  + V            T P+++   S  + P+  +V    
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540

Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
              SW+P  + G         TP +   +   H     W ++A  V      + GL+P+ 
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592

Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
            Y F V A N  G    S+I  S P +     P + G+   ++   L     ++ +  P 
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648

Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
                 + +HW   +   + + GY +  R      G   W   EV  PA    +  +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703

Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
            L K V YE +   F   F    S      T  LE  PS        PQ V      G  
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753

Query: 729 FLGVAVLVS 737
             G A+LVS
Sbjct: 754 -NGTAILVS 761



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)

Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
           PP+  E P  ++ V + EP TL C A G P P + W   G+ +   +      ++ + +G
Sbjct: 28  PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
           +L   R+  G       GVY C A +  G A   +A+  + +        P +  V   +
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
              + C         T SW +D      +     R+ I   G L +  T+  DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202

Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
            +N +    S  A LTVL  P  ++                C  R +P +  V W KD  
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261

Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
            L   ++      T     +  G+   +G Y+C   N +G A  S    V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318

Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
            +P+++    +GR +   C A G+P P + W + G               +  V     L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377

Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
            +  + +   G++ C   N    + T   + V      V+ +     + +G  V+     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432

Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
           DG ++       +P+     R   D V ++        L  G+    +Y       +++ 
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489

Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
           +A    G   +S  +     G+P  P  P   P  IP   S P   V   +   V L W 
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546

Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
           P          Y++E    + G  W+ +   V  TET   + GL  + +Y F + A    
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604

Query: 687 FVSDPSNTAN 696
            +SDPS  ++
Sbjct: 605 GISDPSQISD 614



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)

Query: 34  GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
           G +V   C+    A   P   I W R G    +F     Y P   P    R  + +   L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377

Query: 94  QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
            I  ++  D G+Y C+   +   I    +   + V    + PP      P    V     
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435

Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
             L CVA GSP+P + W+  G  +     ++ Q++NG L+IR  + G +G YTC AS+  
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
           G AT +  + V    V V PP+ +  N                N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 65/238 (27%), Positives = 80/238 (33%), Gaps = 47/238 (19%)

Query: 768  TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
            TG S   S  GS +  S    K   +P    +  + W D    P  HP P S+     + 
Sbjct: 1057 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1116

Query: 827  -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
                   E  C  P  R     T     E    E     TP  R A S   + S      
Sbjct: 1117 VDESYDQEMPCPVPPAR-----TYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1171

Query: 874  -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
                 SP    QP+   C E+             PV+PPP  PP P+  P     Y+S P
Sbjct: 1172 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1228

Query: 915  FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
               +M  D D P  EE         M TRR      LR  E  P S    L  +V G+
Sbjct: 1229 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1280


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,029,305
Number of Sequences: 37866
Number of extensions: 3727163
Number of successful extensions: 34998
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 1244
Number of HSP's that attempted gapping in prelim test: 19898
Number of HSP's gapped (non-prelim): 10936
length of query: 1163
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1050
effective length of database: 13,968,660
effective search space: 14667093000
effective search space used: 14667093000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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