BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo sapiens] (1163 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom... 2379 0.0 gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom... 2365 0.0 gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 733 0.0 gi|118572606 hemicentin 1 [Homo sapiens] 135 2e-31 gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 134 5e-31 gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 134 5e-31 gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 130 9e-30 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28 gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 124 5e-28 gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 122 2e-27 gi|222352127 sidekick 2 [Homo sapiens] 120 1e-26 gi|157311649 neogenin homolog 1 [Homo sapiens] 120 1e-26 gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 117 5e-26 gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 117 5e-26 gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 117 5e-26 gi|109150416 peroxidasin [Homo sapiens] 117 5e-26 gi|27894376 cell adhesion molecule with homology to L1CAM precur... 115 2e-25 gi|83281200 protogenin [Homo sapiens] 115 2e-25 gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 115 2e-25 gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 113 1e-24 gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 111 5e-24 gi|19743806 roundabout 1 isoform b [Homo sapiens] 110 6e-24 gi|4506569 roundabout 1 isoform a [Homo sapiens] 110 6e-24 gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 110 6e-24 gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 110 8e-24 gi|224994173 roundabout 1 isoform d [Homo sapiens] 108 3e-23 gi|224994171 roundabout 1 isoform c [Homo sapiens] 108 3e-23 gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 108 3e-23 >gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo sapiens] Length = 1163 Score = 2379 bits (6166), Expect = 0.0 Identities = 1163/1163 (100%), Positives = 1163/1163 (100%) Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60 Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120 Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180 Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240 Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300 Query: 301 CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360 CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT Sbjct: 301 CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360 Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL Sbjct: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420 Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA Sbjct: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480 Query: 481 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD Sbjct: 481 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540 Query: 541 WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600 WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP Sbjct: 541 WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600 Query: 601 PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660 PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG Sbjct: 601 PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660 Query: 661 TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720 TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL Sbjct: 661 TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720 Query: 721 AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780 AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG Sbjct: 721 AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780 Query: 781 SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840 SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG Sbjct: 781 SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840 Query: 841 PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900 PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP Sbjct: 841 PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900 Query: 901 LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960 LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS Sbjct: 901 LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960 Query: 961 PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020 PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP Sbjct: 961 PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020 Query: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM Sbjct: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080 Query: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR Sbjct: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140 Query: 1141 DATRARLPAYRQPVPHPEQATLL 1163 DATRARLPAYRQPVPHPEQATLL Sbjct: 1141 DATRARLPAYRQPVPHPEQATLL 1163 >gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo sapiens] Length = 1179 Score = 2365 bits (6128), Expect = 0.0 Identities = 1162/1179 (98%), Positives = 1162/1179 (98%), Gaps = 16/1179 (1%) Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60 Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120 Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180 Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240 Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300 Query: 301 CVPSNGLLHPPSASAYLTVLC----------------MPGVIRCPVRANPPLLFVSWTKD 344 CVPSNGLLHPPSASAYLTVL MPGVIRCPVRANPPLLFVSWTKD Sbjct: 301 CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360 Query: 345 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 404 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF Sbjct: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420 Query: 405 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 464 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA Sbjct: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480 Query: 465 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 524 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS Sbjct: 481 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540 Query: 525 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL Sbjct: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600 Query: 585 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 644 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG Sbjct: 601 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660 Query: 645 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 704 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV Sbjct: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720 Query: 705 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 764 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI Sbjct: 721 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780 Query: 765 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 824 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL Sbjct: 781 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840 Query: 825 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 884 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI Sbjct: 841 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900 Query: 885 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 944 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR Sbjct: 901 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960 Query: 945 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1004 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS Sbjct: 961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020 Query: 1005 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1064 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT Sbjct: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080 Query: 1065 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1124 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA Sbjct: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140 Query: 1125 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1163 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL Sbjct: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179 >gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] Length = 1349 Score = 733 bits (1891), Expect = 0.0 Identities = 437/1026 (42%), Positives = 568/1026 (55%), Gaps = 85/1026 (8%) Query: 1 MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55 M+W + + S++ ++G G + E V RAGESVVL CD++ P G+PP +V+ Sbjct: 1 MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60 Query: 56 EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115 EW +FG +PIFI+FG Y P +DP+Y GR L ASL++E +R EDQGWYEC+V LDQ Sbjct: 61 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120 Query: 116 HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175 D F NGSWVHLT+N+PP F ETPP +E +E +T+ C A G+P P VTW G Sbjct: 121 QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178 Query: 176 DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235 LG G+ QV +G+L + V R G YTC+A S +G A H T LLV GPP IV PP+N Sbjct: 179 LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237 Query: 236 STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295 TVN SQD L C AEAYP NLTY+W+ + NV+ + L+ RVRIL+DG+L + +P+D Sbjct: 238 ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297 Query: 296 AGCYTCVPSNGLLHPPSASAYLTV------LCMP----------GVIRCPVRANPPLLFV 339 +G YTCVPSN L PSASAYLTV L MP G IRCPV A PP V Sbjct: 298 SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357 Query: 340 SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399 W KDG+ LQ++K GW+ +GS+ I E+ALG Y+C PYN+LGT G S R++LK Sbjct: 358 KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417 Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 459 PP F P EY QE GRELLIPC+A GDP PV++W KVG+ + + + SL R Sbjct: 418 DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 519 L+KE HG WEC A+N V + ST++ V+GTSPH +V V ANVSWEPG+DGGY Sbjct: 478 LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537 Query: 520 LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 579 Q FSVW KR HDW+SL VP G + LLV L+P T YQFSVLAQNKLG+ F Sbjct: 538 EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593 Query: 580 SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 639 SE+V P T P + T PPR L+A RT +GVLL W PP +D Sbjct: 594 SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646 Query: 640 YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 699 Y++E R ++ WE+LD + GTE E L +D YEFR++A +S+PSN A VS+ Sbjct: 647 YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705 Query: 700 SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 759 + +++P L +PVLAG+V +CFL A+L S LA C +N++R + +RK+ Sbjct: 706 T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760 Query: 760 DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 799 DPPL + KS +P + G SP+S+ L+ QG P SL Sbjct: 761 DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820 Query: 800 QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 859 + + S + P+E I RGPDGRFVM P P +S R + P Sbjct: 821 KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880 Query: 860 PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 904 + F S P + ++P++ PPPA P L GP Sbjct: 881 EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940 Query: 905 GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 955 G L L P R + + L SP PP Y+ P SS + SP Sbjct: 941 GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000 Query: 956 TPPVSP 961 P P Sbjct: 1001 LPTEGP 1006 Score = 35.4 bits (80), Expect = 0.32 Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%) Query: 777 LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 828 L S SP V V S S++ P T P HP P G LPL Sbjct: 970 LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029 Query: 829 ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 876 G P GR F G P + P + + E P L R +S P+ Sbjct: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089 Query: 877 GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930 P L +E SP P APP+ P+ +S R + P L Sbjct: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149 Query: 931 PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 977 P PA P + +DTR + P SPR+ SL V+ + Sbjct: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203 Query: 978 PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1026 + L+ T R R PGLL A +T Q S R S PS + Sbjct: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263 Query: 1027 AGGSYLSPAPGDTS 1040 +G PA G T+ Sbjct: 1264 SGSPSYRPAMGFTT 1277 Score = 33.1 bits (74), Expect = 1.6 Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%) Query: 599 LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 650 LPP ++P L P GL PRG+ PP VP G + LE +G G Sbjct: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110 Query: 651 WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 706 V P A + + P G ++ + ++P ST GL+ Sbjct: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167 Query: 707 SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 762 +R P P+P L VL +S L L+ R + R R P Sbjct: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227 Query: 763 LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 814 L+ + A S + P +V+ + S QS G P+ P + + Sbjct: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282 Query: 815 PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 874 P PP GP P P D V G T + R+G E P TP L S Sbjct: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334 Query: 875 PSGAPQP 881 P+ A P Sbjct: 1335 PAPATSP 1341 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 135 bits (341), Expect = 2e-31 Identities = 135/509 (26%), Positives = 214/509 (42%), Gaps = 61/509 (11%) Query: 20 GRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDP 79 G +P ++V+ ++ D +PP VI WLR G L +PR+ Sbjct: 3624 GTDEPRDITVLRNRQVTLECKSDAVPPP------VITWLRNGERLQA-------TPRV-- 3668 Query: 80 DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ 139 R+ L G LQI + D Y C + + LTVN PP + Sbjct: 3669 ----RI-LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-------LTVNVPPNIK 3716 Query: 140 ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVER 198 P +++ + V L C+A G P P +TW+ G L + + +NG L I+ Sbjct: 3717 GGPQSLVILLNKSTV-LECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHV 3775 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258 +G Y C A++ G+ L V PP I P N TV + +LAC A P + Sbjct: 3776 TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP-KPS 3834 Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------L 307 +W + N ++ ++ + Q R+L GSL +++ DD Y C +NG + Sbjct: 3835 INW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV 3893 Query: 308 LHPPS----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS 363 PPS + +L P VI C + P + WTK+G L L + G+ + G+ Sbjct: 3894 QVPPSIADEPTDFLVTKHAPAVITC-TASGVPFPSIHWTKNGIRL-LPRGDGYRILSSGA 3951 Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423 + I + G Y+C N+ G+A V PP +P E + + +L+P Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHV--HEPPVIQPQPSELHV-ILNNPILLP 4008 Query: 424 CSAQGDPPPVVSWTKVGRGL----QGQAQVDSNSSLILRPLTKEAHGHWECSASN----A 475 C A G P P ++W K G + + A + S I R + ++A G + C A N A Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDA-GTYMCVAQNPAGTA 4067 Query: 476 VARVATSTNVYVLGTSPHVVTNVSVVALP 504 + ++ + V + SPH+ V V P Sbjct: 4068 LGKIKLNVQVPPV-ISPHLKEYVIAVDKP 4095 Score = 127 bits (319), Expect = 6e-29 Identities = 107/378 (28%), Positives = 168/378 (44%), Gaps = 30/378 (7%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQV 186 V L V+ PP Q P + L V P+ L C A G+P P +TW+ G ++ G+ + Sbjct: 3980 VTLHVHEPPVIQPQP-SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038 Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246 +G L+I R R +G Y C A + G+A +L V PPVI K + + ++L Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITL 4098 Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306 +C A+ P +W +D + R R+L GSL++ QP DAG YTC+ +N Sbjct: 4099 SCEADGLPPP-DITWHKDGRAIVE----SIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN- 4152 Query: 307 LLHPPSASAYLTVLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQL 350 + S S LTV P ++ C V P ++W KD L Sbjct: 4153 VAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWKKD-NVLLA 4210 Query: 351 DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410 + ++ G LI+ + G Y+C N+ G + + + P F E P + Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE--DTHTVSLTVHVLPTFTELPGD 4268 Query: 411 EYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ-AQVDSNSSLILRPLTKEAHGHWE 469 + G +L + C A G P P ++WT + V+ +S L++ ++KE G + Sbjct: 4269 VSLNK-GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYV 4327 Query: 470 CSASNAVARVATSTNVYV 487 C+A N+V V VYV Sbjct: 4328 CTAENSVGFVKAIGFVYV 4345 Score = 124 bits (311), Expect = 5e-28 Identities = 100/363 (27%), Positives = 168/363 (46%), Gaps = 31/363 (8%) Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211 +P+TL C A G P P +TW G+ + + Q + +G+L+I V+ G +G YTC A++ Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV 4153 Query: 212 EGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHI 271 GS++ +T+L V PP I + TVN + L C A+ P +W +DN+ + Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP-AINWKKDNV---LL 4209 Query: 272 SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL---LHPPSASAYL--TVLCMPG-- 324 + L + G L L +D+G YTCV +N H S + ++ T +PG Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDV 4269 Query: 325 ------VIRCPVRANP-PLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALGNEDALG 375 +R +A PL ++WT + + D G S+ L+I +++ G Sbjct: 4270 SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE-----LVIERVSKEDSG 4324 Query: 376 EYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVS 435 Y CT NS+G + V +K PP F + + +G ++ C +GDP P + Sbjct: 4325 TYVCTAENSVGFV--KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQ 4382 Query: 436 WTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPH 493 W + G ++ ++ N SL + E G + C A+N V S ++ + SP Sbjct: 4383 WNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL--QSPP 4440 Query: 494 VVT 496 ++T Sbjct: 4441 IIT 4443 Score = 123 bits (308), Expect = 1e-27 Identities = 110/424 (25%), Positives = 173/424 (40%), Gaps = 41/424 (9%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 R R+ SLQI ++ D G Y C + ++ + LTV+ PP+ + T Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG-------SSSTSTKLTVHVPPRIRSTE- 4175 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN-GTLRIRRVERGSSG 202 V E L CVA G P P + WK L G+ + G L + V SG Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG 4235 Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262 YTC A++ G TH L V P P + ++N + + L+C A P F Sbjct: 4236 FYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF 4295 Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL-----------LHPP 311 +NI H + ++++ +D+G Y C N + PP Sbjct: 4296 NNNIIPAHFDSVNGHSELVIE------RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349 Query: 312 S-----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366 S ++ L ++ C V+ +P + W + G +++ Q GSL I Sbjct: 4350 VFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISH--RIRQLGNGSLAI 4406 Query: 367 -ALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425 NEDA G+Y+C N G S + L++PP P E G ++++ C Sbjct: 4407 YGTVNEDA-GDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVIN-AGGKIILNCQ 4462 Query: 426 AQGDPPPVVSWTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATST 483 A G+P P ++W++ G + +V+ SN+SL + KE +EC A N + V Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522 Query: 484 NVYV 487 V V Sbjct: 4523 PVIV 4526 Score = 110 bits (274), Expect = 1e-23 Identities = 113/446 (25%), Positives = 180/446 (40%), Gaps = 47/446 (10%) Query: 92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEVQE 150 +L I + + D+G+YEC I G + V+ PP + P V V Sbjct: 483 NLDIAKVTLSDEGFYEC--------IAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT-VTP 533 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKD--LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208 E L C+ + ++TW+ +D L + + N +L ++ V+ +G Y C Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593 Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV 268 SS GS+ + L V PP + V PKN + +VS+ C A YP +W +++ + Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP-KPKIAWTVNDMFI 652 Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LLHPPS----A 313 R R+ DG+L + P DAG Y C+ SN + P Sbjct: 653 VG----SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708 Query: 314 SAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA 373 S L L V+ C PP V W K L+ F G L I + Sbjct: 709 SELLVALGDITVMECKTSGIPPPQ-VKWFKGDLELRPSTFL-IIDPLLGLLKIQETQDLD 766 Query: 374 LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPV 433 G+Y+C N G A V +PP FI+ P + E+G + +PC QG P P Sbjct: 767 AGDYTCVAINEAGRATGKITLDV--GSPPVFIQEP-ADVSMEIGSNVTLPCYVQGYPEPT 823 Query: 434 VSWTKVGR--------GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485 + W ++ + +Q+ + + IL L G + C A N ++ + T V Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILN-LWASDKGTYICEAENQFGKIQSETTV 882 Query: 486 YVLG-TSPHVVTNVSVVALPKGANVS 510 V G +P + + SV + +G ++ Sbjct: 883 TVTGLVAPLIGISPSVANVIEGQQLT 908 Score = 107 bits (266), Expect = 9e-23 Identities = 110/432 (25%), Positives = 176/432 (40%), Gaps = 55/432 (12%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-----LTVNSPPQFQET 141 L G L I +V + G Y C AN + H +TV+ PP + + Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMA------------ANTAGDHKKEFEVTVHVPPTIKSS 1831 Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERG 199 + V + +PV L+C+A G P P +TW + + QG +++Q+ L+I + Sbjct: 1832 GLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE 1891 Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPK--NSTVNASQDVSLACHAEAYPANL 257 +G YTC A++ G QL V PP + K N TV S V L C A P + Sbjct: 1892 DAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPV 1951 Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGL--------- 307 +W++DN + + L G + + + Q DAG Y CV N Sbjct: 1952 -ITWYKDN----RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006 Query: 308 -LH-PPSASAYLTVLCMPGVIRCPVR-----ANPPLLFVSWTKDGKALQLDKFPGWSQGT 360 +H PS S ++ + V+ PVR P ++W KDG + F Q Sbjct: 2007 QVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNGLQVL 2062 Query: 361 EGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 418 G I+AL + G Y+C N+ G RV + P I ++ + + Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV---PPNIMGEEQNVSVLISQ 2119 Query: 419 ELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASNA 475 + + C + PPP ++W K G L G + ++ S L + + G + C A+N Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNV 2179 Query: 476 VARVATSTNVYV 487 + + NV + Sbjct: 2180 AGKTEKNYNVNI 2191 Score = 106 bits (264), Expect = 1e-22 Identities = 132/499 (26%), Positives = 193/499 (38%), Gaps = 62/499 (12%) Query: 25 EVVSVVG-RAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83 E +SVV R G SV L C+ + P VI W + G ++ + Sbjct: 3064 ESLSVVNVREGTSVSLECE----SNAVPPPVITWYKNGRMITESTHVEI----------- 3108 Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 L G L I+ V D G Y CR ++ D N HL V PP + Sbjct: 3109 ---LADGQMLHIKKAEVSDTGQYVCRAI----NVAGRDDKN---FHLNVYVPPSIEGPER 3158 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNG--TLRIRRVERGS 200 V+ PVTL C A G P P + W K + +V++ +G L+I R + Sbjct: 3159 EVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218 Query: 201 SGVYTCQASSTEGSATHATQLLVLGPPVIVVP--PKNSTVNASQDVSLACHAEAYPANLT 258 SG YTC AS+ EG A L + PP + P + +V ++V L C+A P L Sbjct: 3219 SGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL- 3277 Query: 259 YSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------G 306 W +D + S R+R+ +GS L + D G YTCV +N Sbjct: 3278 IQWLKDGKPI--ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335 Query: 307 LLHPPS-------ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359 + P+ A +T++ I C PP ++W K+G L L Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQ-INWLKNGLPLPLSSHIRLLAA 3394 Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-IERPKEEYFQEVGR 418 + I+ D + Y+C N G +V APP EE G Sbjct: 3395 GQVIRIVRAQVSD-VAVYTCVASNRAGVDNKHYNLQVF--APPNMDNSMGTEEITVLKGS 3451 Query: 419 ELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-SNSSLILRPLTKEAH--GHWECSASNA 475 + C G P P ++W + G+ L A + S ++L+ L E G + C ASN Sbjct: 3452 STSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511 Query: 476 VARVATSTNVYVLGTSPHV 494 V+ + VL PH+ Sbjct: 3512 AGEVSKHFILKVL-EPPHI 3529 Score = 105 bits (261), Expect = 3e-22 Identities = 135/510 (26%), Positives = 206/510 (40%), Gaps = 81/510 (15%) Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83 PE +SVV + SV L C+ A PL I W + G+ P+ + S RI Sbjct: 2393 PENISVVEK--NSVSLTCE----ASGIPLPSITWFKDGW--PVSLS---NSVRI------ 2435 Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ-ETP 142 L G L++ +ED G Y C V E+ G L+V PP E Sbjct: 2436 ---LSGGRMLRLMQTTMEDAGQYTCVV---RNAAGEERKIFG----LSVLVPPHIVGENT 2485 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSS 201 ++V+E + VTL C G+P+P +TW G+ L + + + G L+I V+ + Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545 Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIV-----VPPKNSTVNASQDVSLACHAEAYPAN 256 G YTC ASS G + + L V P I P++ TV + SL C A +YP Sbjct: 2546 GRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP- 2604 Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSN---GLLHPPS 312 T +WF+D + +RIL G +L++L Q D+AG Y+CV +N ++ Sbjct: 2605 ATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660 Query: 313 ASAYLTVLCMPGVIRCP--------VRANP-----------PLLFVSWTKDGKALQLDKF 353 Y+ + G + P ++ N P +SW KDG+ L+ D Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720 Query: 354 PGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEY 412 + +L I G Y+C N AG + V ++ PP+F + + Sbjct: 2721 VNIAANGH-TLQIKEAQISDTGRYTCVASN---IAGEDELDFDVNIQVPPSFQKLWEIGN 2776 Query: 413 FQEVGRE-----------LLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILR 458 + GR + + C PPP ++W K G L +V L + Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIP 2836 Query: 459 PLTKEAHGHWECSASNAVARVATSTNVYVL 488 E G + C A N + +V VL Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866 Score = 104 bits (260), Expect = 4e-22 Identities = 113/414 (27%), Positives = 164/414 (39%), Gaps = 42/414 (10%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146 L +G + IE ++ D G Y+C A + L V+ P + V Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAI-------NSAGATELFYSLQVHVAPSISGSNNMVA 2022 Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVY 204 V PV L C ARG P P +TW G + +QV +G L + + +G Y Sbjct: 2023 VVVN-NPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264 TC A + G L V PP I+ +N +V SQ V L C ++A P T +W +D Sbjct: 2082 TCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP-TLTWLKD 2140 Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312 H +P + I + S L++ Q D G YTC +N + PP+ Sbjct: 2141 G----HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN 2196 Query: 313 --ASAYLTVLCMPG----VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---WSQGTEGS 363 S LT L + + C PP + W K G + D S G + Sbjct: 2197 IGGSDELTQLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQ 2255 Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423 + IA ++ AL YSC N GTA +V ++ E G+ + + Sbjct: 2256 ISIAEKSDAAL--YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE 2313 Query: 424 CSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474 C QG PPP V+W K G L +G +D L L+ + G + C A N Sbjct: 2314 CEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN 2367 Score = 98.2 bits (243), Expect = 4e-20 Identities = 124/497 (24%), Positives = 193/497 (38%), Gaps = 63/497 (12%) Query: 22 GKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDY 81 G E+ + G + L C+ +G PP ++I W + G SP + D Sbjct: 2199 GSDELTQLTVIEGNLISLLCE---SSGIPPPNLI-WKKKG------------SPVLT-DS 2241 Query: 82 VGRVR-LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQE 140 +GRVR L G LQI D Y C V + ++ ++ T+ + Sbjct: 2242 MGRVRILSGGRQLQISIAEKSDAALYSC-VASNVAGTAKKEYNLQVYIRPTITN----SG 2296 Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERG 199 + P + V + ++L C +G P P VTW G L + +G + G L+++ + Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356 Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPAN 256 +G Y C A + G L V PP I+ P+N +V VSL C A P Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416 Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 + +WF+D V L VRIL G LRL+ T +DAG YTCV N Sbjct: 2417 -SITWFKDGWPV----SLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471 Query: 316 YLTVLCMPGVI------------------RCPVRANPPLLFVSWTKDGKALQLDKFPGWS 357 L+VL P ++ C V N P+ ++W KDG+ LQ D+ Sbjct: 2472 -LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHKDGQPLQEDEA---H 2526 Query: 358 QGTEGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI--ERPKEEYF 413 G + + N G Y+C + G S V + A + + E+ Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586 Query: 414 QEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWEC 470 + + C A PP ++W K G L+ + +L + ++ G + C Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646 Query: 471 SASNAVARVATSTNVYV 487 A+N + V V Sbjct: 2647 VATNEAGEMIKHYEVKV 2663 Score = 97.1 bits (240), Expect = 9e-20 Identities = 105/416 (25%), Positives = 165/416 (39%), Gaps = 55/416 (13%) Query: 128 VHLTVNSPPQ-------FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQ- 179 V LTV P+ + P + V E VTL C + P P +TW + + Sbjct: 1064 VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPF 1123 Query: 180 GQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN 239 + +G+++I SG+Y C A++ G+ T A +L V PP I PK+ V Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ 1183 Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVF-----HISRLQPRVRILVDGSLRLLATQPD 294 Q V + C+A+ P + +W + + H+S DG+L + P Sbjct: 1184 VGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVSN--------PDGTLSIDQATPS 1234 Query: 295 DAGCYTCVPSNGL-------------------LHPPSASAYLTVLCMPGV-IRCPVRANP 334 DAG YTCV +N L PP + + + + CP + P Sbjct: 1235 DAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP 1294 Query: 335 PLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPV 393 + W +G+ L + PG S +G+ L+IA GEY C N GT Sbjct: 1295 KPT-IKWLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYN 1352 Query: 394 TRVLLKAPPAFIERPKEEYFQEVGRELL-IPCSAQGDPPPVVSWTKVGRGLQGQAQVDS- 451 +V PP ++ + + +L + C +G P P++ W K + + + + Sbjct: 1353 LKV--HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410 Query: 452 NSSLILR--PLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN----VSVV 501 N+ IL+ T E G + C A N N+ VL + TN VSVV Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVV 1466 Score = 96.7 bits (239), Expect = 1e-19 Identities = 100/375 (26%), Positives = 155/375 (41%), Gaps = 35/375 (9%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP---AVL 146 G +LQI +V D G Y C + + F+ LTV PP ++ +V+ Sbjct: 3017 GRTLQIIRAKVSDGGEYTC-IAINQAGESKKKFS------LTVYVPPSIKDHDSESLSVV 3069 Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSGVYT 205 V+E V+L C + P P +TW G+ + + ++ L I++ E +G Y Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYV 3129 Query: 206 CQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA-SQDVSLACHAEAYPANLTYSWFQD 264 C+A + G L V PP I P + V S V+L C A P T +W ++ Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPP-TIAWLKN 3188 Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312 + + + L+ VRIL GS L++ +Q D+G YTC+ SN + PPS Sbjct: 3189 HKRIENSDSLE--VRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPS 3246 Query: 313 AS-----AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366 + + ++VL V + C P L + W KDGK + + GS + Sbjct: 3247 VAGAEIPSDVSVLLGENVELVCNANGIPTPL-IQWLKDGKPIASGETERIRVSANGSTLN 3305 Query: 367 ALGN-EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425 G G+Y+C N G V + + E+ V + I C Sbjct: 3306 IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECR 3365 Query: 426 AQGDPPPVVSWTKVG 440 A G PPP ++W K G Sbjct: 3366 ATGTPPPQINWLKNG 3380 Score = 94.4 bits (233), Expect = 6e-19 Identities = 116/415 (27%), Positives = 167/415 (40%), Gaps = 52/415 (12%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS-WVHLTVNSPPQFQETPP-AVLE 147 G LQ+ ED G Y C I ++ S L V PP + + Sbjct: 3488 GMVLQLLKAETEDSGKYTC--------IASNEAGEVSKHFILKVLEPPHINGSEEHEEIS 3539 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVYT 205 V P+ L C+A G P P +TW G+ L Q QVQ G LRI + +G YT Sbjct: 3540 VIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRISTAQVEDTGRYT 3598 Query: 206 CQASSTEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 C ASS G + V PP I P++ TV ++ V+L C ++A P + +W + Sbjct: 3599 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLR 3657 Query: 264 DNINVFHISRLQ--PRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320 + RLQ PRVRIL G L++ D YTCV SN + + LTV Sbjct: 3658 NG------ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTREFILTVN 3710 Query: 321 CMPG----------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364 P V+ C + P ++W KDG A+ +S G L Sbjct: 3711 VPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITWRKDG-AVLAGNHARYSILENGFL 3768 Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424 I + G Y C N+ GT +V PP+ P V + + C Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV--HVPPSIAPGP-TNMTVIVNVQTTLAC 3825 Query: 425 SAQGDPPPVVSWTKVGRGL-----QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474 A G P P ++W K G L Q ++ S+ SL++ + + +EC+ +N Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880 Score = 89.7 bits (221), Expect = 1e-17 Identities = 121/503 (24%), Positives = 192/503 (38%), Gaps = 61/503 (12%) Query: 27 VSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID-------- 78 ++ GRA + L P + P V + LP ++Q G P I Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEPTIKWRRLDNMP 833 Query: 79 ----PDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFAN-GSWVHLTVN 133 P V + + +L I L D+G Y C E+ F S +TV Sbjct: 834 IFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA--------ENQFGKIQSETTVTVT 885 Query: 134 S-PPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTL 191 P+V V E + +TL C + G+P+P W L Q +G+L Sbjct: 886 GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSL 945 Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAE 251 I RV+ G YTC AS+ G+ T ++V P I + + V+L C A Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKAS 1005 Query: 252 AYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPP 311 P + W + IS + DGSL +++ +++G Y C +N + Sbjct: 1006 GNP-KPSVIWSKKG---ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-A 1060 Query: 312 SASAYLTVLCMPGV------------------------IRCPVRANPPLLFVSWTKDGKA 347 LTV P V + C V++ PP + ++W K+ + Sbjct: 1061 KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-ITWAKETQL 1119 Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407 + P + GS+ I G Y C N G + ++ + PP Sbjct: 1120 IS-PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV--TQAVKLNVHVPPKIQRG 1176 Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDS-NSSLILRPLTKEA 464 PK Q VG+ + IPC+AQG P PV++W+K G + G+ V + + +L + T Sbjct: 1177 PKHLKVQ-VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235 Query: 465 HGHWECSASNAVARVATSTNVYV 487 G + C A+N T ++V Sbjct: 1236 AGIYTCVATNIAGTDETEITLHV 1258 Score = 87.8 bits (216), Expect = 5e-17 Identities = 109/439 (24%), Positives = 170/439 (38%), Gaps = 49/439 (11%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 R+R SL+++ ++ D G Y C V + ++ + V LTV PP+ P Sbjct: 567 RIRTLANLSLELKSVKFNDAGEYHCMV-------SSEGGSSAASVFLTVQEPPKVTVMPK 619 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203 E V++ C A G P P + W + + +GTL I+ +G+ Sbjct: 620 NQSFTGGSE-VSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGI 678 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 Y C AS++ G+ + L + P ++V V + C P WF+ Sbjct: 679 YGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP-QVKWFK 737 Query: 264 DNINVFHISRLQPRVRILVD---GSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV- 319 ++ L+P +++D G L++ TQ DAG YTCV N A+ +T+ Sbjct: 738 GDL------ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAIN---EAGRATGKITLD 788 Query: 320 -------LCMPGVIRCPVRANPPL-LFVSWTKDG--KALQLDKFP---------GWSQGT 360 + P + + +N L +V + K +LD P SQ Sbjct: 789 VGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLR 848 Query: 361 EGSLIIALGNEDALGEYSCTPYNSLG-TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 G+L I G Y C N G + VT L AP I + G++ Sbjct: 849 TGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE--GQQ 906 Query: 420 LLIPCS-AQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476 L +PC+ G+P P W K L V S+ SL + + + G + C ASN Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966 Query: 477 A--RVATSTNVYVLGTSPH 493 TS V+VL T H Sbjct: 967 GTNNKTTSVVVHVLPTIQH 985 Score = 84.7 bits (208), Expect = 5e-16 Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 33/322 (10%) Query: 82 VGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQET 141 +G+ + L +E + +ED G+Y C + ED V LTV+ P F E Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTC---VANNAAGEDTHT----VSLTVHVLPTFTEL 4265 Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSS 201 P V + + E + L C A G PLP +TW + V + L I RV + S Sbjct: 4266 PGDV-SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN-GHSELVIERVSKEDS 4323 Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVP-PKNSTVNASQDVSLACHAEAYPANLTYS 260 G Y C A ++ G + V PPV P N + L C + P T Sbjct: 4324 GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP-TIQ 4382 Query: 261 WFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLH 309 W + +++ + R+R L +GSL + T +DAG YTCV +N L Sbjct: 4383 WNRKGVDI----EISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS 4438 Query: 310 PP--SASAYLTVLCMPG--VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 PP + TV+ G ++ C P ++W++ G ++ D + + SL Sbjct: 4439 PPIITLEPVETVINAGGKIILNCQATGEPQPT-ITWSRQGHSISWD--DRVNVLSNNSLY 4495 Query: 366 IALGNEDALGEYSCTPYNSLGT 387 IA ++ E+ C N +G+ Sbjct: 4496 IADAQKEDTSEFECVARNLMGS 4517 Score = 79.3 bits (194), Expect = 2e-14 Identities = 107/467 (22%), Positives = 166/467 (35%), Gaps = 70/467 (14%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP-PAV 145 + G L++ ED G Y C+ + + + ++ V PP T P Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAG-------TSQKYFNIDVLVPPTIIGTNFPNE 1462 Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV--QNGTLRIRRVERGSSGV 203 + V V L C +G+P P + W GK L G V++ + L ++ R G Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGR 1522 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVS--------LACHAEAYPA 255 Y C S+ G +L I +PP N + D+S L C P Sbjct: 1523 YQCTVSNAAGKQAKDIKL------TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPM 1576 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGS--LRLLATQPDDAGCYTCVPSN-------- 305 +W++D + S+ + +D L + Q D+ YTC +N Sbjct: 1577 P-AITWYKDGQPIMSSSQ-----ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKS 1630 Query: 306 ---GLLHPPSASAYL-------TVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFP 354 + PP L V+ + C NP P+L +W KDG ++ + Sbjct: 1631 FHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL--TWLKDGVPVKANDNI 1688 Query: 355 GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEYF 413 G + L I E G+Y C + AG + V + PPA + YF Sbjct: 1689 RIEAGGK-KLEIMSAQEIDRGQYICV---ATSVAGEKEIKYEVDVLVPPAIEGGDETSYF 1744 Query: 414 QEVGRELL-IPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWE 469 + LL + C G PPP + W K G+ + G + + L++ G + Sbjct: 1745 IVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYR 1804 Query: 470 CSASNAV--------ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508 C A+N V + G S VV VAL AN Sbjct: 1805 CMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851 Score = 79.0 bits (193), Expect = 3e-14 Identities = 108/415 (26%), Positives = 166/415 (40%), Gaps = 51/415 (12%) Query: 151 LEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQAS 209 L+P + C S LP +R G LG Q + + L I +V G Y C A Sbjct: 444 LQPGQIPCSV-DSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAV 502 Query: 210 STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC-HAEAYPANLTYSWFQDNINV 268 S+ G+ T V PP ++ P N TV + L C A NLT+ ++ + Sbjct: 503 SSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562 Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHPPSASAYLTVLCMPGVIR 327 R+R L + SL L + + +DAG Y C V S G +AS +LTV P V Sbjct: 563 AE----PARIRTLANLSLELKSVKFNDAGEYHCMVSSEG--GSSAASVFLTVQEPPKVTV 616 Query: 328 CPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372 P P ++WT + + + + ++G+L I Sbjct: 617 MPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND--MFIVGSHRYRMTSDGTLFIKNAAPK 674 Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432 G Y C NS GT + R ++AP + + E +G ++ C G PPP Sbjct: 675 DAGIYGCLASNSAGTDKQNSTLR-YIEAPKLMV--VQSELLVALGDITVMECKTSGIPPP 731 Query: 433 VVSWTKVGRGLQGQAQVDSNSSLILRPL--------TKEAH-GHWECSASNAVARVATST 483 V W K G ++ ++ LI+ PL T++ G + C A N R AT Sbjct: 732 QVKWFK------GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGK 784 Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVW----YTPLAKRP 534 +G+ P + + V++ G+NV+ P + GY + W P+ RP Sbjct: 785 ITLDVGSPPVFIQEPADVSMEIGSNVTL-PCYVQGYPEPTIKWRRLDNMPIFSRP 838 Score = 77.4 bits (189), Expect = 7e-14 Identities = 128/550 (23%), Positives = 204/550 (37%), Gaps = 98/550 (17%) Query: 17 GADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPR 76 G G PE V+V+ + S+V PPA I W + G L + Sbjct: 2575 GVGSDGNPEDVTVILNSPTSLVCEAYSYPPA------TITWFKDGTPLESNRNIRI---- 2624 Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS-- 134 L G +LQI + ++ G Y C + A H V Sbjct: 2625 ----------LPGGRTLQILNAQEDNAGRYSCVA---------TNEAGEMIKHYEVKVYI 2665 Query: 135 PPQFQE-------TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 PP + P ++++ +TL C A P ++W G+ L Sbjct: 2666 PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA 2725 Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPV---------IVVPPKNST 237 NG TL+I+ + +G YTC AS+ G + + PP ++ +N Sbjct: 2726 NGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE 2785 Query: 238 ---VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQP 293 V + +SL C A P T +W++D H +V IL G L++ + Sbjct: 2786 AKDVIINNPISLYCETNAAPPP-TLTWYKDG----HPLTSSDKVLILPGGRVLQIPRAKV 2840 Query: 294 DDAGCYTCVPSNG-----------LLHPPSASAY-------LTVLCMPGVIRCPVRANPP 335 +DAG YTCV N +L PP +TVL + + + P Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSP 2900 Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA-LGEYSCTPYNSLGTAGPSPVT 394 SW KDG+ L D + + G ++ L + +G Y C N+ G+A Sbjct: 2901 APRNSWQKDGQPLLEDDHHKFL--SNGRILQILNTQITDIGRYVCVAENTAGSA--KKYF 2956 Query: 395 RVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454 + + PP+ I E V + + C G PPP +SW L+ + + N++ Sbjct: 2957 NLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW------LKNEQPIKLNTN 3010 Query: 455 LILRPLTKEAH---------GHWECSASNAV--ARVATSTNVYV-LGTSPHVVTNVSVVA 502 ++ P + G + C A N ++ S VYV H ++SVV Sbjct: 3011 TLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN 3070 Query: 503 LPKGANVSWE 512 + +G +VS E Sbjct: 3071 VREGTSVSLE 3080 Score = 47.4 bits (111), Expect = 8e-05 Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 33/215 (15%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G + +L C++ P I+W R G +D + R+R SL Sbjct: 4364 GGNAILNCEVKGD----PTPTIQWNRKG---------------VDIEISHRIRQLGNGSL 4404 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 I G ED G Y C V + + E + LT+ SPP P + + Sbjct: 4405 AIYGTVNEDAGDYTC-VATNEAGVVERSMS------LTLQSPPIITLEPVETV-INAGGK 4456 Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213 + L C A G P P +TW +G + + N +L I ++ + + C A + G Sbjct: 4457 IILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516 Query: 214 SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248 S +LV P ++ V S +A + S+ C Sbjct: 4517 S------VLVRVPVIVQVHGGFSQWSAWRACSVTC 4545 >gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform ROBO2a [Homo sapiens] Length = 1394 Score = 134 bits (337), Expect = 5e-31 Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I Sbjct: 151 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 209 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G+YTC ++ G + +L V P + P N V + V C + P Sbjct: 210 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 269 Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313 T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A Sbjct: 270 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 320 Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356 SA LTV P V+R C + NP P +F W K+G L FP Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 376 Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405 Q G L I G Y C T S+ VT VL PP I Sbjct: 377 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 436 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462 + V L+ C A GDP PV+SW K G G +A + +L ++ L Sbjct: 437 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496 Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509 G + C A+++ + S + V + + N + LP + Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 556 Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569 SW+PG G + + + + W ++A V V GL+P+T Y F V Sbjct: 557 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 612 Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619 A N G P S+ V + +P A G+ ++ L G V VR T Sbjct: 613 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 664 Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674 P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V Sbjct: 665 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 722 Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734 YE ++ + F S + V T+ + P PQ V VG ++V Sbjct: 723 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 774 Score = 97.8 bits (242), Expect = 5e-20 Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 46 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G G Y C A + G A +A+ + L P + V A + Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 L C T W +D + I + R+ I G L + T+ DAG YTCV Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 220 Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347 +N + S A LTV P +R P+ P V W KD Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 280 Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407 L ++ + +L I G Y C N +G S V +APP F+ R Sbjct: 281 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 335 Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457 P+++ + GR + PC +G+P P V W K G + + V L + Sbjct: 336 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394 Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517 + + G++ C A + + V + + L AN + DG Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 449 Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567 L + PL W+ A L + L+ ++ Sbjct: 450 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503 Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627 +A + G +S ++ G + +++P P S P+ V T V L W Sbjct: 504 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 558 Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685 P Y++E + S W+ + V T V GL + +Y F + A Sbjct: 559 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 616 Query: 686 SFVSDPS 692 +SDPS Sbjct: 617 QGLSDPS 623 Score = 85.5 bits (210), Expect = 3e-16 Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88 VV AGE +L C PP G P I W + RID D R+ + Sbjct: 158 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 199 Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148 +G L I R D G Y C + D LTV P F P + + Sbjct: 200 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 253 Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208 +E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A Sbjct: 254 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 311 Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267 + G + L V PP VV P++ V + V+ C + P + + + N Sbjct: 312 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 371 Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320 +F QP R V G L + Q DAG Y C + +L + LT Sbjct: 372 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431 Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 P +++ P PL +SW K+G + P + +G+L Sbjct: 432 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 490 Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396 I G Y+C +S G S V V Sbjct: 491 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 521 Score = 37.4 bits (85), Expect = 0.084 Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%) Query: 23 KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80 +P + + G A +++ + G LL A PL VI WL+ GF P DP Sbjct: 431 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 479 Query: 81 YVGRVRLQKGASLQIEGLRVEDQGWYEC 108 R +Q+ +LQI+ LR+ D G Y C Sbjct: 480 ---RATIQEQGTLQIKNLRISDTGTYTC 504 >gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform ROBO2b [Homo sapiens] Length = 1378 Score = 134 bits (337), Expect = 5e-31 Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I Sbjct: 135 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G+YTC ++ G + +L V P + P N V + V C + P Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253 Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313 T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A Sbjct: 254 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 304 Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356 SA LTV P V+R C + NP P +F W K+G L FP Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 360 Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405 Q G L I G Y C T S+ VT VL PP I Sbjct: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462 + V L+ C A GDP PV+SW K G G +A + +L ++ L Sbjct: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480 Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509 G + C A+++ + S + V + + N + LP + Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540 Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569 SW+PG G + + + + W ++A V V GL+P+T Y F V Sbjct: 541 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 596 Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619 A N G P S+ V + +P A G+ ++ L G V VR T Sbjct: 597 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 648 Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674 P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V Sbjct: 649 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 706 Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734 YE ++ + F S + V T+ + P PQ V VG ++V Sbjct: 707 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 758 Score = 97.8 bits (242), Expect = 5e-20 Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 30 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G G Y C A + G A +A+ + L P + V A + Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 L C T W +D + I + R+ I G L + T+ DAG YTCV Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 204 Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347 +N + S A LTV P +R P+ P V W KD Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264 Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407 L ++ + +L I G Y C N +G S V +APP F+ R Sbjct: 265 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 319 Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457 P+++ + GR + PC +G+P P V W K G + + V L + Sbjct: 320 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378 Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517 + + G++ C A + + V + + L AN + DG Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 433 Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567 L + PL W+ A L + L+ ++ Sbjct: 434 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487 Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627 +A + G +S ++ G + +++P P S P+ V T V L W Sbjct: 488 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 542 Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685 P Y++E + S W+ + V T V GL + +Y F + A Sbjct: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 600 Query: 686 SFVSDPS 692 +SDPS Sbjct: 601 QGLSDPS 607 Score = 85.5 bits (210), Expect = 3e-16 Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88 VV AGE +L C PP G P I W + RID D R+ + Sbjct: 142 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 183 Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148 +G L I R D G Y C + D LTV P F P + + Sbjct: 184 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 237 Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208 +E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A Sbjct: 238 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 295 Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267 + G + L V PP VV P++ V + V+ C + P + + + N Sbjct: 296 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 355 Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320 +F QP R V G L + Q DAG Y C + +L + LT Sbjct: 356 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415 Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 P +++ P PL +SW K+G + P + +G+L Sbjct: 416 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 474 Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396 I G Y+C +S G S V V Sbjct: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 505 Score = 37.4 bits (85), Expect = 0.084 Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%) Query: 23 KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80 +P + + G A +++ + G LL A PL VI WL+ GF P DP Sbjct: 415 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 463 Query: 81 YVGRVRLQKGASLQIEGLRVEDQGWYEC 108 R +Q+ +LQI+ LR+ D G Y C Sbjct: 464 ---RATIQEQGTLQIKNLRISDTGTYTC 488 >gi|110431348 deleted in colorectal carcinoma [Homo sapiens] Length = 1447 Score = 130 bits (326), Expect = 9e-30 Identities = 178/725 (24%), Positives = 282/725 (38%), Gaps = 108/725 (14%) Query: 154 VTLRCVARGSP-LPHVTWKLRGKDL--GQGQGQVQVQNGTLRIRRV-----ERGSSGVYT 205 V L C A +P + WK G L G + + Q+ NG+L I+ + + G+Y Sbjct: 57 VLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQ 116 Query: 206 CQASSTEGSA--THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 C+AS + + + ++ V GP + ++ T V L C P T W + Sbjct: 117 CEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMP-TIHWQK 175 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMP 323 + ++ I RV +L G+L++ QP D G Y C N A + +L P Sbjct: 176 NQQDLTPIPG-DSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDP 234 Query: 324 G----------------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTE 361 G V+ C V PP F +W + + +QL + +S Sbjct: 235 GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF-TWLRGEEVIQL-RSKKYSLLGG 292 Query: 362 GSLIIALGNEDALGEYSC-TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420 +L+I+ +D G Y+C Y + + + +T + PP F+ P Y E ++ Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELT---VLVPPWFLNHPSNLYAYE-SMDI 348 Query: 421 LIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478 C+ G P P V+W K G + Q+ S+L + + K G ++C A N Sbjct: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGN 408 Query: 479 VATSTNVY----------VLGTSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWY 527 TS + VL ++P V V V+ + +SW P + G +Q F+V++ Sbjct: 409 AQTSAQLIVPKPAIPSSSVLPSAPRDV--VPVLVSSRFVRLSWRPPAEAKGNIQTFTVFF 466 Query: 528 TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAP 587 + +R + G+ L V L+P Y F V+A N+ G G S+ + A Sbjct: 467 SREGDNRERALN-----TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521 Query: 588 EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQ 646 + P ++P P+ L AV T P +L+ W+PP + GY L + Sbjct: 522 Q-----------PELQVPGPV---ENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTE 567 Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNT---------A 695 S G E + V G +L GL K Y R +A+ G VS T A Sbjct: 568 VSTGKE-QNIEVDGLSYKL--EGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA 624 Query: 696 NVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRK 755 LEV SR+ LP P +G G + G + R+ RR Sbjct: 625 PPQNVSLEVVNSRSIKVSWLPPP--SGTQNG-----------FITGYKIRHRKTTRRGEM 671 Query: 756 RLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHP 815 + L + TG GS V+ + + G+ PS + + S P Sbjct: 672 ETLEPNNLWYLFTGLEK-----GSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726 Query: 816 DPPSS 820 D PSS Sbjct: 727 DQPSS 731 Score = 76.3 bits (186), Expect = 2e-13 Identities = 187/772 (24%), Positives = 286/772 (37%), Gaps = 118/772 (15%) Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGF-LLPIFIQFGLYSPRIDPDYVGRVR 86 SV G++V+L C+++ P+ I W + L PI P V Sbjct: 148 SVTAFMGDTVLLKCEVIGE----PMPTIHWQKNQQDLTPI------------PGDSRVVV 191 Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP------QFQE 140 L GA LQI L+ D G Y C P G+ + + S P F + Sbjct: 192 LPSGA-LQISRLQPGDIGIYRCSA-----RNPASS-RTGNEAEVRILSDPGLHRQLYFLQ 244 Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVER 198 P V+ ++ + V L C G P P TW LRG+++ Q + + G L I V Sbjct: 245 RPSNVVAIEGKDAV-LECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNVTD 302 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258 SG+YTC + + + + +L VL PP + P N S D+ C P T Sbjct: 303 DDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP-T 361 Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN---------GLLH 309 +W ++ V Q I+ +LR+L D G Y CV N L+ Sbjct: 362 VNWMKNGDVVIPSDYFQ----IVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417 Query: 310 PPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKA---LQL----------DKFPGW 356 P A +VL PV + + +SW +A +Q ++ Sbjct: 418 PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERAL 477 Query: 357 SQGTEGSLIIALGN--EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQ 414 + GSL + +GN +A+ + YN G S +V + P + P E Q Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ-PELQVPGPVEN-LQ 535 Query: 415 EVG---RELLI----PCSAQGDPPPVVSW----TKVGRGLQGQAQVDSNSSLILRPLTKE 463 V +LI P A G PV + T+V G + +VD S L L K Sbjct: 536 AVSTSPTSILITWEPPAYANG---PVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKF 591 Query: 464 AHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSV-VALPKGANVSWEP---GFD 516 A N ++ ++ V+ S NVS+ V + VSW P G Sbjct: 592 TEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQ 651 Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576 G++ + + + +R + + P +L GL+ +QY F V A G+ Sbjct: 652 NGFITGYKIRHRKTTRRGE------METLEPNNLWYLFT-GLEKGSQYSFQVSAMTVNGT 704 Query: 577 GPFSE-IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635 GP S PE L +++P P L +++ W PP Sbjct: 705 GPPSNWYTAETPEN--------DLDESQVP---DQPSSLHVRPQTNCIIMSWTPPLNPNI 753 Query: 636 RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVS--DP 691 + GY++ GS E + V + + L Y L AF AG V + Sbjct: 754 VVRGYIIGYGVGSPYAETV--RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811 Query: 692 SNTANVS--TSGLEVYPSRTQLPGLLPQ---PVLAGV-VGGVCFLGVAVLVS 737 + T +++ T ++ YP P +P P+L V V V AV VS Sbjct: 812 ATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVS 863 Score = 41.6 bits (96), Expect = 0.004 Identities = 114/537 (21%), Positives = 175/537 (32%), Gaps = 104/537 (19%) Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616 GL+P+T Y+FSV+ S +S + T AAP P ++ + Sbjct: 909 GLKPNTMYEFSVMVTKNRRSSTWSMTAHAT-----TYEAAPTSAPKDLTV-------ITR 956 Query: 617 VRTPRGVLLHWDPPELVPKRLDGYV----LEGRQGSQGWEVLDPAVAGTETELLVPGLIK 672 PR V++ W PP ++ Y+ L+ W + ++G + L Sbjct: 957 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDW--IMETISGDRLTHQIMDLNL 1014 Query: 673 DVLYEFRL--------------VAFAGSFVSDPSNTAN-----------------VSTSG 701 D +Y FR+ + F V P AN + S Sbjct: 1015 DTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRST 1074 Query: 702 LEVYPSRTQLP---GLLPQPVLAGVVGGVCFLGV-AVLVSILAGCLLNRRRAARRRRKRL 757 L P P + PQ +V V +GV VLV ++ + RR +A++R+KR Sbjct: 1075 LNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRA 1134 Query: 758 RQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDP 817 P + ++ P+ R S + TP H Sbjct: 1135 THSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQS 1194 Query: 818 PSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSP-- 875 + G G D + R A R P +L D S++P Sbjct: 1195 ETQLGSKSTSH--SGQDTE-----EAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAV 1247 Query: 876 -SGAPQPLCIEDISPVAPPPAAPPSPLPG-PGPLLQYLSLPFFREMNVD----------- 922 S P P A P PSP G P P +P F ++VD Sbjct: 1248 VSAIPVPTL-----ESAQYPGILPSPTCGYPHPQFTLRPVP-FPTLSVDRGFGAGRSQSV 1301 Query: 923 GDWPPLEEPS--PAAPPDYMDTRRCPTSSF----------LRS---PETPP----VSPRE 963 + P ++P P + P++ + P+ + LRS P PP + P+ Sbjct: 1302 SEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKV 1361 Query: 964 SLPGAVVGAGATAEPPYTALADWTL----RERLLPGLLPAAPRGSLTSQSSGRGSAS 1016 + G T + A L R LLP +P AP S S SA+ Sbjct: 1362 PYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSAN 1418 Score = 36.2 bits (82), Expect = 0.19 Identities = 24/96 (25%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Query: 490 TSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPV 548 ++P +T ++ P+ VSW+P + G + + ++YT P DW+ + Sbjct: 946 SAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPI---DDWIMETISG 1002 Query: 549 GAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584 + L T Y F + A+N G GP S+ +L Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPIL 1038 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 125 bits (313), Expect = 3e-28 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86 VVG A +VL C + P I W R G +L QF Sbjct: 2400 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2440 Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144 ++G LQ++ L D G Y C + A + V + +++ P + PPA Sbjct: 2441 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2490 Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203 V V + L C A G P P V+W+ L + ++ G+LRI+ V +G Sbjct: 2491 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 Y C AS++ GS L VL PP I P N T+ A L C A P L W Sbjct: 2550 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2609 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313 F + Q R+L +L L A P D+ + CV SN + +H P Sbjct: 2610 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667 Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368 A + + P V+ C P VSW+K G L + G+ G+L I Sbjct: 2668 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2725 Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427 G Y+C+ NS G A V L + + +P + V E+L+PC A Sbjct: 2726 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781 Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485 G P P ++W K G + QV L + + E G++ C A N+ T + Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841 Query: 486 YVLGTSPHVVTN 497 V P V+ N Sbjct: 2842 VV--QVPPVIEN 2851 Score = 116 bits (290), Expect = 1e-25 Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 V LTV + P + P V V E E V L C A G P P +TW+ G ++ G + Sbjct: 2749 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2807 Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247 G LRI +G Y C A ++ GSA T+L+V PPVI + + L Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2867 Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306 C A P N+T W +D V S + + I G L + + DAG YTC N Sbjct: 2868 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2922 Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350 + +LT+L +P +RC R +P + WT + + + Sbjct: 2923 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2979 Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408 G S+ GS + A+ ED+ G Y C N +G V+ V +K P Sbjct: 2980 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 3033 Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466 + VG + + C +GDP P + W K G L+G N SL + ++ G Sbjct: 3034 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 3093 Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492 ++C A N + VA + VL ++P Sbjct: 3094 RYQCLAENEMG-VAKKVVILVLQSAP 3118 Score = 108 bits (270), Expect = 3e-23 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%) Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83 P VV V A E V+L C+ A P I W + G + + Sbjct: 2763 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2802 Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142 ++ G L+I ED G Y C I ++ + L V PP + Sbjct: 2803 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2853 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201 P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E + Sbjct: 2854 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2912 Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261 G YTC A + G A L +L PV P + ++ + L C A P Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972 Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314 D +S +L+ A +D+G Y C N + + S Sbjct: 2973 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 3026 Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364 +YL V + G I+ C VR +P + + W KDG L+ Q GSL Sbjct: 3027 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 3082 Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424 I D G Y C N +G A V ++L++ P F P++ + G ++ + C Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3139 Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482 A G+P P + W + G+ L+ ++ + + SL L + G ++C A N + Sbjct: 3140 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3199 Query: 483 TNVYVLG 489 + V G Sbjct: 3200 AFLVVRG 3206 Score = 108 bits (269), Expect = 4e-23 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139 L +G LQI+ +V D G Y C + +D ++ + PP FQ Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1550 Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 E V E +E+ P L C P P +TW + L G +Q Sbjct: 1551 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1610 Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242 G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1670 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301 VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C Sbjct: 1671 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725 Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345 V N + PP + +T + V + C V A+P V+W KD Sbjct: 1726 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1784 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 +AL L + GT +L + G Y+C N+ G + ++ + PPAF Sbjct: 1785 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1841 Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459 + P+ + VG + ++ C P P V+W K G+ L Q + L ++ Sbjct: 1842 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1901 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487 G + C SN + + V Sbjct: 1902 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1929 Score = 106 bits (264), Expect = 1e-22 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92 G+ V L C+ G+PP V WL+ G SP + D +R G S Sbjct: 2041 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 2083 Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150 L ++GLR D G Y C H P + A V++ V PP ++ L + Sbjct: 2084 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2136 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209 E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+ Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196 Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267 S G A L V PPV+ V + V V L C A P L SW +D Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2255 Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314 + S Q SL+L A D+G Y+CV + ++ PP S Sbjct: 2256 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308 Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370 T L + P + C + P ++W KDG+A L + S+ T L Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2360 Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427 DA G Y+C + G S RV ++APP + P+ F VG +L++ CS + Sbjct: 2361 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2415 Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484 +P P ++W + G LQ A + L L+ L+ G + C+A NA + + Sbjct: 2416 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475 Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510 V + H V + + P NVS Sbjct: 2476 VEI-----HTVPTIR--SGPPAVNVS 2494 Score = 103 bits (257), Expect = 1e-21 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%) Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85 V V A +V L C PA P+ I WL+ G LP SPR+ Sbjct: 1661 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1703 Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140 L+ G LQ+ V D Y C + E+ + + L V PP+ E Sbjct: 1704 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754 Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198 A+L V+L C P P VTW + L G+ +V + GT L++ R Sbjct: 1755 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1809 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254 SG+YTC+A + G QL VL PP P+ V L+C +A P Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869 Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305 T +W++D + L R + L G L + Q D G Y+C SN Sbjct: 1870 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1924 Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356 P V P V+ C V + P V+W KD ++ G Sbjct: 1925 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1983 Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416 S+G G L ++ G Y+C N+ A V VL+ AP E+ Sbjct: 1984 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 2040 Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470 G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099 Query: 471 SASNAVARVATSTNVYVL 488 A N A V VL Sbjct: 2100 VAHNPAGEDARLHTVNVL 2117 Score = 102 bits (253), Expect = 3e-21 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147 G L + ++ +G Y C + + +D + L V+ PPQ PP + Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 1078 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206 V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C Sbjct: 1079 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138 Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 A + G A +L VL PP ++ P N T ++L C A P WF+ Sbjct: 1139 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1197 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312 V S + + L++ TQ D+G Y+C+ SN +L PPS Sbjct: 1198 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1254 Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 + VL + C V +P P L +W KDG+ L + +G L+ Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1310 Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421 L N + G YSC N++G VLL AP + EE V + Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1369 Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478 + C A P P ++W K G + + L + KE G + C +N + Sbjct: 1370 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1429 Query: 479 VATSTNVYVL 488 + +V VL Sbjct: 1430 AVKNYHVEVL 1439 Score = 101 bits (252), Expect = 4e-21 Identities = 121/434 (27%), Positives = 177/434 (40%), Gaps = 59/434 (13%) Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150 A LQ++ V D G Y C L+Q + N L V P F L V+E Sbjct: 933 ALLQVDRADVWDAGHYTCEA--LNQAGRSEKHYN-----LNVWVAPVFPLRESHTLTVRE 985 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207 P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+ Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045 Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264 S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1104 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313 V LQ + + SL + Q G Y+CV N +L PP Sbjct: 1105 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161 Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366 L L P + C PP + W + + + PG E + ++ Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1211 Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417 A G E G YSC N G A + VL+ PP+ EE + + G Sbjct: 1212 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1269 Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474 + + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N Sbjct: 1270 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329 Query: 475 AVARVATSTNVYVL 488 AV + VL Sbjct: 1330 AVGEKTKHFQLSVL 1343 Score = 100 bits (249), Expect = 8e-21 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%) Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146 + G L+I G V D+G Y+C V F DF L V++PP + + Sbjct: 269 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 321 Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205 V E V L C ARG P P++TW G L V + G L++ R + +GVYT Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381 Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262 C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 440 Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305 + + V + R+ DGS LRL + +G Y+CV S+ Sbjct: 441 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 496 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363 LL T++ P + C + P+ + W ++G+ A +L SQGT + Sbjct: 497 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 553 Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423 L I D G ++C N GTAG V + P +E P +Y P Sbjct: 554 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 613 Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468 + A PP V W G L G+ + + PL E G + Sbjct: 614 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672 Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528 C+A+N + VL P++ A+ + A+V+ E G S W+ Sbjct: 673 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 729 Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587 + + W+ + V V L + Q + +A N GS + ++ P Sbjct: 730 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 785 Query: 588 EGLPTTPAAPG 598 + P+ PG Sbjct: 786 PRITLPPSLPG 796 Score = 95.5 bits (236), Expect = 3e-19 Identities = 131/517 (25%), Positives = 201/517 (38%), Gaps = 77/517 (14%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70 V+ + + P+++ G + ++G L P A P+ I+WL+ G Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 536 Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130 R + G +G +L I+ + ++ G + C+ + G+ V + Sbjct: 537 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 584 Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173 +V+ E P VLEV + C V RG P P + W Sbjct: 585 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 639 Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231 G G+ G + L+I +V+ G+YTC A++ G + L VL PP I Sbjct: 640 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 699 Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290 P N V + V+L C A P SWF+ + V V + VDG LR+ Sbjct: 700 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 754 Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335 Q DAG Y CV SN GL ++ P L P ++ PVR P Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 814 Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394 + W KDG + PG G L +A G YSC +++G V Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 874 Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453 +V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++ Sbjct: 875 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 930 Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487 L + + GH+ C A N R N+ V Sbjct: 931 DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967 Score = 94.4 bits (233), Expect = 6e-19 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%) Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75 Q A R P VSVV L C+ G+PP + W R G P+ + GL Sbjct: 1066 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1114 Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134 +LQ +G SL +E + G Y C L L+V Sbjct: 1115 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1157 Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191 PP+ P + P+TL C A G P P + W + + G+ + G L Sbjct: 1158 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1217 Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249 ++ + + SG+Y+C AS+ G A + VL PP I + Q L C+ Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277 Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303 +P +WF+D + HIS DG L ++L AG Y+C+ Sbjct: 1278 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1327 Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343 +N + + L+VL P ++ V N P+ + +W K Sbjct: 1328 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386 Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+ Sbjct: 1387 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1443 Query: 404 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455 E +E +V L + C + PPP + W K G+ + + QV L Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1503 Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487 + ++P G + C A+N NV + Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536 Score = 92.8 bits (229), Expect = 2e-18 Identities = 114/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147 G L+IE ++ D G Y C + A + + L VN PP+ P Sbjct: 747 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 797 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204 V PV L C A G+P P + W G + G +QV G L + SG Y Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264 +C A S G L V PP I+ N +V A++ V+L C + A P + SW++D Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 916 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSN---------------G 306 L+PR + + LL DAG YTC N Sbjct: 917 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA 970 Query: 307 LLHPPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362 + P S LTV P + C R P +SW KDG+ L PG G + Sbjct: 971 PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 1024 Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 ++ LG G Y+C N +G + V + A P + Sbjct: 1025 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 1084 Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476 + C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N Sbjct: 1085 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1144 Query: 477 ARVATSTNVYVL 488 R + VL Sbjct: 1145 GRAERKFELSVL 1156 Score = 81.6 bits (200), Expect = 4e-15 Identities = 189/772 (24%), Positives = 269/772 (34%), Gaps = 158/772 (20%) Query: 145 VLEVQELEPVTLR-------CVARGSPLPHVTWKL--RGKDLGQGQGQVQVQNGTLRIRR 195 VLE++ L V L C G+P P VTW+ + L G ++ G+L + Sbjct: 4 VLEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLAS 63 Query: 196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAY 253 V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++L C A + Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123 Query: 254 P---------ANLT--------YSW-----------FQDNINVFHISRLQP----RVRIL 281 P A L Y W D H R+QP R Sbjct: 124 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183 Query: 282 VDGSLRLLATQPDDAGCYTCVPSNGLLHPPS------ASAYLTVLCMPGV---IRCPVRA 332 GS + A + P+ PP+ A A VL + G ++C + Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC-WTS 242 Query: 333 NPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPS 391 P V WTKD + + L P +G ++ G+ G Y C ++ G Sbjct: 243 GVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 301 Query: 392 PVTRVLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV 449 RV APP I E V + L+ C A+G P P ++W K G L +V Sbjct: 302 FQLRV--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV 358 Query: 450 ---DSNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALP 504 L L G + C ASNAV A AT +VYV T VV Sbjct: 359 VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418 Query: 505 KGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY 564 G V+ E G S W HH+ +PV ++ + + Sbjct: 419 AGRPVALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLET 456 Query: 565 QFSVL---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621 SVL + + SG +S V S+P G + ++PP L GL V T Sbjct: 457 DGSVLRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIV 512 Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYE 677 G P EL P + G + Q G E+ VA T L + + D Sbjct: 513 G-----QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD---- 562 Query: 678 FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVS 737 +G F +N A + + +EV PG+L P+ G G S Sbjct: 563 -----HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSS 611 Query: 738 ILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPS 797 A C DPP+ P G SP S Sbjct: 612 FPAAC-----------------DPPVHRGWGAHPKPPLVEGWCSPGS------------- 641 Query: 798 LRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849 LWG+P G P + PP PL +E + +G + T A + + Sbjct: 642 -----LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 684 Score = 63.9 bits (154), Expect = 8e-10 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142 R +LQ G SL I +D G Y+C + E++ V + V S P FQ Sbjct: 3074 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3123 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202 P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183 Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227 Y C A + GSAT L+V G P Sbjct: 3184 TYDCVAHNLLGSATARAFLVVRGEP 3208 Score = 56.2 bits (134), Expect = 2e-07 Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%) Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147 LQI + ED G Y C V L + + H+ V PP + P V E Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 1457 Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204 V+ +TL C + P P + W G+ + QV + L+I+ + SG Y Sbjct: 1458 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1517 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244 C A++ G +L+ PP+ S + + Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577 Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303 L C A P +W++++ + V +L G L++ + ++AG Y+C Sbjct: 1578 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1632 Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344 SN +L PP +TV V ++CP N P+ +SW ++ Sbjct: 1633 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1691 Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 G L P +G ++ ++ Y C N G+A RV + PP Sbjct: 1692 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1747 Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460 E+ + + +PC P P V+W K + L +V +L L Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807 Query: 461 TKEAHGHWECSASNAVAR 478 G + C A NA R Sbjct: 1808 RLSDSGMYTCEALNAAGR 1825 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 125 bits (313), Expect = 3e-28 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86 VVG A +VL C + P I W R G +L QF Sbjct: 3591 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 3631 Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144 ++G LQ++ L D G Y C + A + V + +++ P + PPA Sbjct: 3632 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 3681 Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203 V V + L C A G P P V+W+ L + ++ G+LRI+ V +G Sbjct: 3682 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 Y C AS++ GS L VL PP I P N T+ A L C A P L W Sbjct: 3741 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 3800 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313 F + Q R+L +L L A P D+ + CV SN + +H P Sbjct: 3801 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858 Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368 A + + P V+ C P VSW+K G L + G+ G+L I Sbjct: 3859 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 3916 Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427 G Y+C+ NS G A V L + + +P + V E+L+PC A Sbjct: 3917 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972 Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485 G P P ++W K G + QV L + + E G++ C A N+ T + Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032 Query: 486 YVLGTSPHVVTN 497 V P V+ N Sbjct: 4033 VV--QVPPVIEN 4042 Score = 116 bits (290), Expect = 1e-25 Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 V LTV + P + P V V E E V L C A G P P +TW+ G ++ G + Sbjct: 3940 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 3998 Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247 G LRI +G Y C A ++ GSA T+L+V PPVI + + L Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 4058 Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306 C A P N+T W +D V S + + I G L + + DAG YTC N Sbjct: 4059 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 4113 Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350 + +LT+L +P +RC R +P + WT + + + Sbjct: 4114 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 4170 Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408 G S+ GS + A+ ED+ G Y C N +G V+ V +K P Sbjct: 4171 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 4224 Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466 + VG + + C +GDP P + W K G L+G N SL + ++ G Sbjct: 4225 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 4284 Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492 ++C A N + VA + VL ++P Sbjct: 4285 RYQCLAENEMG-VAKKVVILVLQSAP 4309 Score = 113 bits (283), Expect = 9e-25 Identities = 140/526 (26%), Positives = 199/526 (37%), Gaps = 102/526 (19%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G S +L C GRPP + W R G P+ ++ G R R L Sbjct: 800 GRSALLACRA---TGRPP-PTVTWRR-GDGQPLGLRLGAGRG-------SRSRQPDSGVL 847 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 E + EDQ Y C + + + + + +T ++PPQ + P V V E +P Sbjct: 848 FFESVAPEDQAPYVCEARNVFGKVQAE-----ARLIVTGHAPPQIASSAPTV-RVLEGQP 901 Query: 154 VTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212 V+L C+ G PLP W G+ L G +G+L + R + +G Y+C A++T Sbjct: 902 VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA 961 Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV---- 268 GS +L+V PP I + N SL C A PA T +W ++ + Sbjct: 962 GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP-TITWTKETNALTSRG 1020 Query: 269 --FHISR------LQPRVR--------------------------------------ILV 282 +++S+ QP + +L Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP 1080 Query: 283 DGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSAS---AYLTVLCMPGV-IR 327 GSLRL Q D+G Y C SN G+ PP L VL + + Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140 Query: 328 CPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG 386 C NP P L SW+KDG LQ +G +GS+ A G Y C NS G Sbjct: 1141 CVAEGNPEPQL--SWSKDGVVLQ-------GRGPQGSVHFAAIRTSDAGRYRCEASNSAG 1191 Query: 387 TAGPSPVTRVLLKAPPAFIERPKEEYFQEV-GRELLIPCSAQGDPPPVVSWTK--VGRGL 443 RVL PP + + V G +PC A+G P P V+W K L Sbjct: 1192 VDAWEVELRVL--EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPL 1249 Query: 444 QGQ--AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487 GQ V SL L ++ G +EC A+N V + + V Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295 Score = 108 bits (271), Expect = 2e-23 Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%) Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87 +V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL Sbjct: 1309 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364 Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146 +G SL ++ D G Y CR + DF HL V +PP A Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 1416 Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202 EV L V L+C G P P V W + + G +QVQ LRI G G Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476 Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259 Y C A S G QL V PP I + V +D V L C A P N+T Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 1535 Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308 WF+D + +++ V L+L Q DAG YTC SN + Sbjct: 1536 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591 Query: 309 HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360 PP+ V P + C R +P P L SW +G L + + T Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 1647 Query: 361 EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 +GS++ + E + G YSC + G A V + P + + VG+ Sbjct: 1648 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 1706 Query: 420 LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476 L +PC A G P P + W + GR L G ++L + + + G + C A+N Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766 Query: 477 ARVATSTNVYVLG 489 V V G Sbjct: 1767 GTAGAEVEVSVHG 1779 Score = 108 bits (270), Expect = 3e-23 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%) Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83 P VV V A E V+L C+ A P I W + G + + Sbjct: 3954 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 3993 Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142 ++ G L+I ED G Y C I ++ + L V PP + Sbjct: 3994 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 4044 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201 P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E + Sbjct: 4045 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 4103 Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261 G YTC A + G A L +L PV P + ++ + L C A P Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163 Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314 D +S +L+ A +D+G Y C N + + S Sbjct: 4164 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 4217 Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364 +YL V + G I+ C VR +P + + W KDG L+ Q GSL Sbjct: 4218 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 4273 Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424 I D G Y C N +G A V ++L++ P F P++ + G ++ + C Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 4330 Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482 A G+P P + W + G+ L+ ++ + + SL L + G ++C A N + Sbjct: 4331 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 4390 Query: 483 TNVYVLG 489 + V G Sbjct: 4391 AFLVVRG 4397 Score = 108 bits (269), Expect = 4e-23 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139 L +G LQI+ +V D G Y C + +D ++ + PP FQ Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 2741 Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 E V E +E+ P L C P P +TW + L G +Q Sbjct: 2742 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 2801 Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242 G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 2861 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301 VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C Sbjct: 2862 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916 Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345 V N + PP + +T + V + C V A+P V+W KD Sbjct: 2917 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 2975 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 +AL L + GT +L + G Y+C N+ G + ++ + PPAF Sbjct: 2976 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 3032 Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459 + P+ + VG + ++ C P P V+W K G+ L Q + L ++ Sbjct: 3033 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 3092 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487 G + C SN + + V Sbjct: 3093 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 3120 Score = 106 bits (264), Expect = 1e-22 Identities = 111/419 (26%), Positives = 166/419 (39%), Gaps = 45/419 (10%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 R+ + +L I+G+ ED G Y C+ + + V L PP Sbjct: 653 RIHVDAQGTLIIQGVAPEDAGNYSCQA-------TNEVGTDQETVTLYYTDPPSVSAVNA 705 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSG 202 VL V E L C A G P P V W G ++ +G +G LRI + +G Sbjct: 706 VVL-VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGKLRIPAAQERDAG 761 Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262 YTC+A + G A+ QL V P + P++ TV + LAC A P T +W Sbjct: 762 TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTWR 820 Query: 263 QDNINVFHI---SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-------------- 305 + + + + R R G L + P+D Y C N Sbjct: 821 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 880 Query: 306 GLLHPPSASAYLTVLCMPGV---IRCPVRANPPLLFVSWTKDGKALQLDKFPG--WSQGT 360 G P AS+ TV + G + C V A PL W KDG+ L PG S Sbjct: 881 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP----PGSRHSIRA 936 Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420 +GSL + ++ G YSC N+ G+ ++++ PP I + G Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPR-IHPTATHHITNEGVPA 993 Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQA---QVDSNSSLILRPLTKEAHGHWECSASNAV 476 +PC A G P P ++WTK L + V +L++ + + G + C+A+N V Sbjct: 994 SLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052 Score = 106 bits (264), Expect = 1e-22 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92 G+ V L C+ G+PP V WL+ G SP + D +R G S Sbjct: 3232 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 3274 Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150 L ++GLR D G Y C H P + A V++ V PP ++ L + Sbjct: 3275 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 3327 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209 E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+ Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387 Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267 S G A L V PPV+ V + V V L C A P L SW +D Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 3446 Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314 + S Q SL+L A D+G Y+CV + ++ PP S Sbjct: 3447 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499 Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370 T L + P + C + P ++W KDG+A L + S+ T L Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 3551 Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427 DA G Y+C + G S RV ++APP + P+ F VG +L++ CS + Sbjct: 3552 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 3606 Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484 +P P ++W + G LQ A + L L+ L+ G + C+A NA + + Sbjct: 3607 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666 Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510 V + H V + + P NVS Sbjct: 3667 VEI-----HTVPTIR--SGPPAVNVS 3685 Score = 103 bits (257), Expect = 1e-21 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%) Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85 V V A +V L C PA P+ I WL+ G LP SPR+ Sbjct: 2852 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 2894 Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140 L+ G LQ+ V D Y C + E+ + + L V PP+ E Sbjct: 2895 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945 Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198 A+L V+L C P P VTW + L G+ +V + GT L++ R Sbjct: 2946 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 3000 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254 SG+YTC+A + G QL VL PP P+ V L+C +A P Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060 Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305 T +W++D + L R + L G L + Q D G Y+C SN Sbjct: 3061 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 3115 Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356 P V P V+ C V + P V+W KD ++ G Sbjct: 3116 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 3174 Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416 S+G G L ++ G Y+C N+ A V VL+ AP E+ Sbjct: 3175 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 3231 Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470 G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290 Query: 471 SASNAVARVATSTNVYVL 488 A N A V VL Sbjct: 3291 VAHNPAGEDARLHTVNVL 3308 Score = 103 bits (256), Expect = 1e-21 Identities = 120/434 (27%), Positives = 175/434 (40%), Gaps = 59/434 (13%) Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150 A LQ++ V D G Y C H E + WV P F L V+E Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 2176 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207 P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+ Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236 Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264 S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 2295 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313 V LQ + + SL + Q G Y+CV N +L PP Sbjct: 2296 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352 Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366 L L P + C PP + W + + + PG E + ++ Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 2402 Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417 A G E G YSC N G A + VL+ PP+ EE + + G Sbjct: 2403 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 2460 Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474 + + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N Sbjct: 2461 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520 Query: 475 AVARVATSTNVYVL 488 AV + VL Sbjct: 2521 AVGEKTKHFQLSVL 2534 Score = 102 bits (254), Expect = 2e-21 Identities = 221/888 (24%), Positives = 320/888 (36%), Gaps = 153/888 (17%) Query: 14 ISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73 + G G + + G A VLG + PP +P V++ L L + G Sbjct: 1089 VQVGDSGHYECTASNPAGSASHRYVLGVQV-PPQVQPGPRVLKVLVGEALDLNCVAEGNP 1147 Query: 74 SPRIDPDYVGRVRLQKG--ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHL 130 P++ G V +G S+ +R D G Y C + +W V L Sbjct: 1148 EPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA--------SNSAGVDAWEVEL 1199 Query: 131 TVNSPPQF-QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKL--RGKDLGQGQGQVQVQ 187 V PP + + +LE E +L C ARG+P P VTW+ + L G ++ Sbjct: 1200 RVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE 1259 Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVS 245 G+L + V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++ Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319 Query: 246 LACHAEAYPANLTYSWFQDNINV----------FHISRLQPRVRILVD--GSLRLLATQP 293 L C A +P W +D V + + Q L+D SL Q Sbjct: 1320 LECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378 Query: 294 DDAGCYTCVPSNG-----------LLHPPS---ASAYLTVLCMPGV---IRCPVRANPPL 336 D+G Y+C N +L PPS A A VL + G ++C + P Sbjct: 1379 GDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC-WTSGVPT 1437 Query: 337 LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPSPVTR 395 V WTKD + + L P +G ++ G+ G Y C ++ G R Sbjct: 1438 PQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLR 1496 Query: 396 VLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV---D 450 V APP I E V + L+ C A+G P P ++W K G L +V Sbjct: 1497 V--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR 1553 Query: 451 SNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508 L L G + C ASNAV A AT +VYV T VV G Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP 1613 Query: 509 VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568 V+ E G S W HH+ +PV ++ + + SV Sbjct: 1614 VALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLETDGSV 1651 Query: 569 L---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLL 625 L + + SG +S V S+P G + ++PP L GL V T G Sbjct: 1652 LRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIVG--- 1704 Query: 626 HWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLV 681 P EL P + G + Q G E+ VA T L + + D Sbjct: 1705 --QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD-------- 1753 Query: 682 AFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAG 741 +G F +N A + + +EV PG+L P+ G G S A Sbjct: 1754 -HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSSFPAA 1806 Query: 742 CLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQS 801 C DPP+ P G SP S Sbjct: 1807 C-----------------DPPVHRGWGAHPKPPLVEGWCSPGS----------------- 1832 Query: 802 LLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849 LWG+P G P + PP PL +E + +G + T A + + Sbjct: 1833 -LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 1875 Score = 102 bits (253), Expect = 3e-21 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147 G L + ++ +G Y C + + +D + L V+ PPQ PP + Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 2269 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206 V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C Sbjct: 2270 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329 Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 A + G A +L VL PP ++ P N T ++L C A P WF+ Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 2388 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312 V S + + L++ TQ D+G Y+C+ SN +L PPS Sbjct: 2389 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 2445 Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 + VL + C V +P P L +W KDG+ L + +G L+ Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 2501 Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421 L N + G YSC N++G VLL AP + EE V + Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 2560 Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478 + C A P P ++W K G + + L + KE G + C +N + Sbjct: 2561 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 2620 Query: 479 VATSTNVYVL 488 + +V VL Sbjct: 2621 AVKNYHVEVL 2630 Score = 100 bits (249), Expect = 8e-21 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%) Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146 + G L+I G V D+G Y+C V F DF L V++PP + + Sbjct: 1460 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 1512 Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205 V E V L C ARG P P++TW G L V + G L++ R + +GVYT Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 1572 Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262 C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW Sbjct: 1573 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 1631 Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305 + + V + R+ DGS LRL + +G Y+CV S+ Sbjct: 1632 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 1687 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363 LL T++ P + C + P+ + W ++G+ A +L SQGT + Sbjct: 1688 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 1744 Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423 L I D G ++C N GTAG V + P +E P +Y P Sbjct: 1745 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 1804 Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468 + A PP V W G L G+ + + PL E G + Sbjct: 1805 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 1863 Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528 C+A+N + VL P++ A+ + A+V+ E G S W+ Sbjct: 1864 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 1920 Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587 + + W+ + V V L + Q + +A N GS + ++ P Sbjct: 1921 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 1976 Query: 588 EGLPTTPAAPG 598 + P+ PG Sbjct: 1977 PRITLPPSLPG 1987 Score = 97.1 bits (240), Expect = 9e-20 Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%) Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210 +P+ + C S LP RG+ LG+ + + N + I R + G Y C A S Sbjct: 442 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500 Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268 G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 553 Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324 R+ P RV L D SL + P D G Y CV SN AS +L V P Sbjct: 554 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 609 Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367 V + C + P +SW+++ +ALQ D +G+LII Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 666 Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427 + EDA G YSC N +GT T L P + VG E ++ C A Sbjct: 667 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 722 Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487 G PPP V W + G + + S+ L + + G + C A N + + + V Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782 Query: 488 LGTSPHV 494 G +P + Sbjct: 783 -GHAPQL 788 Score = 96.7 bits (239), Expect = 1e-19 Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%) Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61 +S+ GR K ++V +V GE+ VL C +L G P + + W+R Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 552 Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121 R+ P GRV SL+I G+ D G Y+C Sbjct: 553 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 590 Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178 ANG + V L V PQ + Q +E V + C A G P PH++W + L Sbjct: 591 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 648 Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237 Q ++ V GTL I+ V +G Y+CQA++ G+ L PP + Sbjct: 649 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708 Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297 V ++ L C A P W++ + + L P G LR+ A Q DAG Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 761 Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341 YTC N L SA L V L ++ C PP V+W Sbjct: 762 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 819 Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396 + DG+ L L G Q G L + Y C N G V Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879 Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453 APP E G+ + +PC G P P W K GR L + + ++ Sbjct: 880 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 938 Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502 SL L +E G + C A+N + V T+ H +TN V A Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 993 Score = 95.1 bits (235), Expect = 3e-19 Identities = 112/392 (28%), Positives = 153/392 (39%), Gaps = 65/392 (16%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH---LTVNSPPQFQETPP 143 L SL++ ++V D G YEC GS H L V PPQ Q P Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTA----------SNPAGSASHRYVLGVQVPPQVQ-PGP 1126 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203 VL+V E + L CVA G+P P ++W G L QG+G G++ + +G Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGRG----PQGSVHFAAIRTSDAGR 1181 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAYPANLTYSW 261 Y C+AS++ G +L VL PP + + A ++ SL C A P Sbjct: 1182 YRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241 Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLC 321 + H QP V +L +GSL L + P D+G Y C +N + S A L V Sbjct: 1242 KGPSSEPLH---GQPGVAVLEEGSLFLASVSPADSGDYECQATNE-VGSTSRRAKLVVYV 1297 Query: 322 MPGVIRCPVRANP-----------------PLLFVSWTKDGKALQLDKFP------GWSQ 358 P + +AN P+ + W KD QL P GW Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA---QLVGVPLGWAGYGWDL 1354 Query: 359 G----------TEG-SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI-E 406 G EG SL E G YSC N GTA +L+ PP+ + Sbjct: 1355 GWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD--FHLLVLTPPSVLGA 1412 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTK 438 +E G ++ + C G P P V WTK Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444 Score = 94.4 bits (233), Expect = 6e-19 Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147 G L+IE ++ D G Y C + A + + L VN PP+ P Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 1988 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204 V PV L C A G+P P + W G + G +QV G L + SG Y Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264 +C A S G L V PP I+ N +V A++ V+L C + A P + SW++D Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 2107 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309 L+PR + + LL DAG YTC N H Sbjct: 2108 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 2161 Query: 310 ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362 P S LTV P + C R P +SW KDG+ L PG G + Sbjct: 2162 PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 2215 Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 ++ LG G Y+C N +G + V + A P + Sbjct: 2216 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 2275 Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476 + C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N Sbjct: 2276 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 2335 Query: 477 ARVATSTNVYVL 488 R + VL Sbjct: 2336 GRAERKFELSVL 2347 Score = 94.4 bits (233), Expect = 6e-19 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%) Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75 Q A R P VSVV L C+ G+PP + W R G P+ + GL Sbjct: 2257 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 2305 Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134 +LQ +G SL +E + G Y C L L+V Sbjct: 2306 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 2348 Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191 PP+ P + P+TL C A G P P + W + + G+ + G L Sbjct: 2349 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 2408 Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249 ++ + + SG+Y+C AS+ G A + VL PP I + Q L C+ Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468 Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303 +P +WF+D + HIS DG L ++L AG Y+C+ Sbjct: 2469 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 2518 Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343 +N + + L+VL P ++ V N P+ + +W K Sbjct: 2519 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577 Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+ Sbjct: 2578 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 2634 Query: 404 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455 E +E +V L + C + PPP + W K G+ + + QV L Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 2694 Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487 + ++P G + C A+N NV + Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727 Score = 94.0 bits (232), Expect = 8e-19 Identities = 96/344 (27%), Positives = 141/344 (40%), Gaps = 50/344 (14%) Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247 +G+LR+ +V+ G SG Y C AS+ GSA+H L V PP + P+ V + + L Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140 Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG- 306 C AE P SW +D + LQ R GS+ A + DAG Y C SN Sbjct: 1141 CVAEGNP-EPQLSWSKDGV------VLQGRG---PQGSVHFAAIRTSDAGRYRCEASNSA 1190 Query: 307 ----------LLHPPSASAYLTVLCMPGV------IRCPVRANPPLLFVSWTKDGKALQL 350 +L PP A T + V + CP R P V+W K + L Sbjct: 1191 GVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ-VTWRKGPSSEPL 1249 Query: 351 DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410 PG + EGSL +A + G+Y C N +G+ S ++++ PP+ E ++ Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPSIREDGRK 1307 Query: 411 EYFQEV-GRELLIPCSAQGDPPPVVSWTK-----------VGRG-------LQGQAQVDS 451 + G+ L + C A G P P + W K G G + G +D Sbjct: 1308 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367 Query: 452 NSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495 SL + + G + C A N ++ VL T P V+ Sbjct: 1368 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL-TPPSVL 1410 Score = 93.6 bits (231), Expect = 1e-18 Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70 V+ + + P+++ G + ++G L P A P+ I+WL+ G Sbjct: 1677 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 1727 Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130 R + G +G +L I+ + ++ G + C+ + G+ V + Sbjct: 1728 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 1775 Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173 +V+ E P VLEV + C V RG P P + W Sbjct: 1776 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 1830 Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231 G G+ G + L+I +V+ G+YTC A++ G + L VL PP I Sbjct: 1831 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 1890 Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290 P N V + V+L C A P SWF+ + V V + VDG LR+ Sbjct: 1891 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 1945 Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335 Q DAG Y CV SN GL ++ P L P ++ PVR P Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 2005 Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394 + W KDG + PG G L +A G YSC +++G V Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 2065 Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453 +V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++ Sbjct: 2066 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 2121 Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487 L + + GH+ C A N N+ V Sbjct: 2122 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158 Score = 92.4 bits (228), Expect = 2e-18 Identities = 131/490 (26%), Positives = 187/490 (38%), Gaps = 110/490 (22%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88 V+ GE VL C+ +G PP VI W R G + + Sbjct: 707 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 742 Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145 +G+S L+I + D G Y CR + E A+ + L V PQ E P V Sbjct: 743 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 795 Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198 V+ L C A G P P VTW+ G LG G+G Q +G L V Sbjct: 796 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 854 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256 Y C+A + G +L+V G PP I V Q VSL C A Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914 Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310 W +D L P R I DGSL L + AG Y+CV +N G H Sbjct: 915 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 968 Query: 311 -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359 P+A+ ++T +P + C V + P ++WTK+ AL + P ++ Sbjct: 969 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 1026 Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 EG+L+IA + G Y CT N++G + V A ++ ++E G Sbjct: 1027 KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYV-------WEEYG-- 1077 Query: 420 LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARV 479 L+P + SL L + GH+EC+ASN Sbjct: 1078 -LLP----------------------------SGSLRLAQVQVGDSGHYECTASNP---A 1105 Query: 480 ATSTNVYVLG 489 ++++ YVLG Sbjct: 1106 GSASHRYVLG 1115 Score = 63.9 bits (154), Expect = 8e-10 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142 R +LQ G SL I +D G Y+C + E++ V + V S P FQ Sbjct: 4265 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 4314 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202 P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374 Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227 Y C A + GSAT L+V G P Sbjct: 4375 TYDCVAHNLLGSATARAFLVVRGEP 4399 Score = 56.2 bits (134), Expect = 2e-07 Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%) Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147 LQI + ED G Y C V L + + H+ V PP + P V E Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 2648 Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204 V+ +TL C + P P + W G+ + QV + L+I+ + SG Y Sbjct: 2649 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 2708 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244 C A++ G +L+ PP+ S + + Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768 Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303 L C A P +W++++ + V +L G L++ + ++AG Y+C Sbjct: 2769 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 2823 Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344 SN +L PP +TV V ++CP N P+ +SW ++ Sbjct: 2824 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 2882 Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 G L P +G ++ ++ Y C N G+A RV + PP Sbjct: 2883 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 2938 Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460 E+ + + +PC P P V+W K + L +V +L L Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998 Query: 461 TKEAHGHWECSASNAVAR 478 G + C A NA R Sbjct: 2999 RLSDSGMYTCEALNAAGR 3016 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 125 bits (313), Expect = 3e-28 Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86 VVG A +VL C + P I W R G +L QF Sbjct: 2309 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2349 Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144 ++G LQ++ L D G Y C + A + V + +++ P + PPA Sbjct: 2350 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2399 Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203 V V + L C A G P P V+W+ L + ++ G+LRI+ V +G Sbjct: 2400 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458 Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 Y C AS++ GS L VL PP I P N T+ A L C A P L W Sbjct: 2459 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2518 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313 F + Q R+L +L L A P D+ + CV SN + +H P Sbjct: 2519 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576 Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368 A + + P V+ C P VSW+K G L + G+ G+L I Sbjct: 2577 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2634 Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427 G Y+C+ NS G A V L + + +P + V E+L+PC A Sbjct: 2635 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690 Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485 G P P ++W K G + QV L + + E G++ C A N+ T + Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750 Query: 486 YVLGTSPHVVTN 497 V P V+ N Sbjct: 2751 VV--QVPPVIEN 2760 Score = 118 bits (295), Expect = 4e-26 Identities = 110/386 (28%), Positives = 162/386 (41%), Gaps = 37/386 (9%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 V LTV + P + P V V E E V L C A G P P +TW+ G ++ G + Sbjct: 2658 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2716 Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247 G LRI +G Y C A ++ GSA T+L+V PPVI + + L Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2776 Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306 C A P N+T W +D V S + + I G L + + DAG YTC N Sbjct: 2777 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2831 Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350 + +LT+L +P +RC R +P + WT + + + Sbjct: 2832 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2888 Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408 G S+ GS + A+ ED+ G Y C N +G V+ V +K P Sbjct: 2889 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 2942 Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466 + VG + + C +GDP P + W K G L+G N SL +R ++ G Sbjct: 2943 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAG 3002 Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492 ++C A N + VA + VL ++P Sbjct: 3003 RYQCLAENEMG-VAKKVVILVLQSAP 3027 Score = 108 bits (271), Expect = 2e-23 Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%) Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87 +V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL Sbjct: 27 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82 Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146 +G SL ++ D G Y CR + DF HL V +PP A Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 134 Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202 EV L V L+C G P P V W + + G +QVQ LRI G G Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194 Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259 Y C A S G QL V PP I + V +D V L C A P N+T Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 253 Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308 WF+D + +++ V L+L Q DAG YTC SN + Sbjct: 254 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309 Query: 309 HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360 PP+ V P + C R +P P L SW +G L + + T Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 365 Query: 361 EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 +GS++ + E + G YSC + G A V + P + + VG+ Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 424 Query: 420 LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476 L +PC A G P P + W + GR L G ++L + + + G + C A+N Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484 Query: 477 ARVATSTNVYVLG 489 V V G Sbjct: 485 GTAGAEVEVSVHG 497 Score = 108 bits (271), Expect = 2e-23 Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%) Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83 P VV V A E V+L C+ A P I W + G + + Sbjct: 2672 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2711 Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142 ++ G L+I ED G Y C I ++ + L V PP + Sbjct: 2712 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2762 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201 P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E + Sbjct: 2763 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2821 Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261 G YTC A + G A L +L PV P + ++ + L C A P Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881 Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314 D +S +L+ A +D+G Y C N + + S Sbjct: 2882 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 2935 Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364 +YL V + G I+ C VR +P + + W KDG L+ Q GSL Sbjct: 2936 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 2991 Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424 I D G Y C N +G A V ++L++ P F P++ + G ++ + C Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3048 Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482 A G+P P + W + G+ L+ ++ + + SL L + G ++C A N + Sbjct: 3049 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3108 Query: 483 TNVYVLG 489 + V G Sbjct: 3109 AFLVVRG 3115 Score = 108 bits (269), Expect = 4e-23 Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%) Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139 L +G LQI+ +V D G Y C + +D ++ + PP FQ Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1459 Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 E V E +E+ P L C P P +TW + L G +Q Sbjct: 1460 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1519 Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242 G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1579 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301 VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C Sbjct: 1580 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634 Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345 V N + PP + +T + V + C V A+P V+W KD Sbjct: 1635 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1693 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 +AL L + GT +L + G Y+C N+ G + ++ + PPAF Sbjct: 1694 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1750 Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459 + P+ + VG + ++ C P P V+W K G+ L Q + L ++ Sbjct: 1751 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1810 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487 G + C SN + + V Sbjct: 1811 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1838 Score = 106 bits (264), Expect = 1e-22 Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92 G+ V L C+ G+PP V WL+ G SP + D +R G S Sbjct: 1950 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 1992 Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150 L ++GLR D G Y C H P + A V++ V PP ++ L + Sbjct: 1993 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2045 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209 E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+ Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105 Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267 S G A L V PPV+ V + V V L C A P L SW +D Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2164 Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314 + S Q SL+L A D+G Y+CV + ++ PP S Sbjct: 2165 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217 Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370 T L + P + C + P ++W KDG+A L + S+ T L Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2269 Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427 DA G Y+C + G S RV ++APP + P+ F VG +L++ CS + Sbjct: 2270 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2324 Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484 +P P ++W + G LQ A + L L+ L+ G + C+A NA + + Sbjct: 2325 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384 Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510 V + H V + + P NVS Sbjct: 2385 VEI-----HTVPTIR--SGPPAVNVS 2403 Score = 103 bits (257), Expect = 1e-21 Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%) Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85 V V A +V L C PA P+ I WL+ G LP SPR+ Sbjct: 1570 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1612 Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140 L+ G LQ+ V D Y C + E+ + + L V PP+ E Sbjct: 1613 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663 Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198 A+L V+L C P P VTW + L G+ +V + GT L++ R Sbjct: 1664 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1718 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254 SG+YTC+A + G QL VL PP P+ V L+C +A P Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778 Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305 T +W++D + L R + L G L + Q D G Y+C SN Sbjct: 1779 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1833 Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356 P V P V+ C V + P V+W KD ++ G Sbjct: 1834 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1892 Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416 S+G G L ++ G Y+C N+ A V VL+ AP E+ Sbjct: 1893 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 1949 Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470 G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008 Query: 471 SASNAVARVATSTNVYVL 488 A N A V VL Sbjct: 2009 VAHNPAGEDARLHTVNVL 2026 Score = 102 bits (254), Expect = 2e-21 Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 59/434 (13%) Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150 A LQ++ V D G Y C H E + WV P F L V+E Sbjct: 842 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 894 Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207 P L C RG P P ++W+ G+ L G+G G V L + + + G YTC+ Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954 Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264 S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D Sbjct: 955 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1013 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313 V LQ + + SL + Q G Y+CV N +L PP Sbjct: 1014 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070 Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366 L L P + C PP + W + + + PG E + ++ Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1120 Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417 A G E G YSC N G A + VL+ PP+ EE + + G Sbjct: 1121 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1178 Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474 + + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N Sbjct: 1179 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238 Query: 475 AVARVATSTNVYVL 488 AV + VL Sbjct: 1239 AVGEKTKHFQLSVL 1252 Score = 102 bits (253), Expect = 3e-21 Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147 G L + ++ +G Y C + + +D + L V+ PPQ PP + Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 987 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206 V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C Sbjct: 988 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047 Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263 A + G A +L VL PP ++ P N T ++L C A P WF+ Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1106 Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312 V S + + L++ TQ D+G Y+C+ SN +L PPS Sbjct: 1107 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1163 Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 + VL + C V +P P L +W KDG+ L + +G L+ Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1219 Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421 L N + G YSC N++G VLL AP + EE V + Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1278 Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478 + C A P P ++W K G + + L + KE G + C +N + Sbjct: 1279 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1338 Query: 479 VATSTNVYVL 488 + +V VL Sbjct: 1339 AVKNYHVEVL 1348 Score = 100 bits (249), Expect = 8e-21 Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%) Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146 + G L+I G V D+G Y+C V F DF L V++PP + + Sbjct: 178 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 230 Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205 V E V L C ARG P P++TW G L V + G L++ R + +GVYT Sbjct: 231 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 290 Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262 C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW Sbjct: 291 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 349 Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305 + + V + R+ DGS LRL + +G Y+CV S+ Sbjct: 350 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363 LL T++ P + C + P+ + W ++G+ A +L SQGT + Sbjct: 406 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 462 Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423 L I D G ++C N GTAG V + P +E P +Y P Sbjct: 463 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 522 Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468 + A PP V W G L G+ + + PL E G + Sbjct: 523 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 581 Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528 C+A+N + VL P++ A+ + A+V+ E G S W+ Sbjct: 582 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 638 Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587 + + W+ + V V L + Q + +A N GS + ++ P Sbjct: 639 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 694 Query: 588 EGLPTTPAAPG 598 + P+ PG Sbjct: 695 PRITLPPSLPG 705 Score = 94.7 bits (234), Expect = 4e-19 Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%) Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75 Q A R P VSVV L C+ G+PP + W R G P+ + GL Sbjct: 975 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1023 Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134 +LQ +G SL +E + G Y C L L+V Sbjct: 1024 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1066 Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191 PP+ P + P+TL C A G P P + W + + G+ + G L Sbjct: 1067 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1126 Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249 ++ + + SG+Y+C AS+ G A + VL PP I + Q L C+ Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186 Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303 +P +WF+D + HIS DG L ++L AG Y+C+ Sbjct: 1187 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1236 Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343 +N + + L+VL P ++ V N P+ + +W K Sbjct: 1237 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295 Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+ Sbjct: 1296 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1352 Query: 404 F------IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455 E +E +V L + C + PPP + W K G+ + + QV L Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1412 Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487 + ++P G + C A+N NV + Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445 Score = 94.0 bits (232), Expect = 8e-19 Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%) Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147 G L+IE ++ D G Y C + A + + L VN PP+ P Sbjct: 656 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 706 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204 V PV L C A G+P P + W G + G +QV G L + SG Y Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264 +C A S G L V PP I+ N +V A++ V+L C + A P + SW++D Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 825 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309 L+PR + + LL DAG YTC N H Sbjct: 826 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 879 Query: 310 ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362 P S LTV P + C R P +SW KDG+ L PG G + Sbjct: 880 PVFPLRESHTLTVREGHPTRLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 933 Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 ++ LG G Y+C N +G + V + A P + Sbjct: 934 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 993 Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476 + C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N Sbjct: 994 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1053 Query: 477 ARVATSTNVYVL 488 R + VL Sbjct: 1054 GRAERKFELSVL 1065 Score = 93.6 bits (231), Expect = 1e-18 Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70 V+ + + P+++ G + ++G L P A P+ I+WL+ G Sbjct: 395 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 445 Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130 R + G +G +L I+ + ++ G + C+ + G+ V + Sbjct: 446 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 493 Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173 +V+ E P VLEV + C V RG P P + W Sbjct: 494 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 548 Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231 G G+ G + L+I +V+ G+YTC A++ G + L VL PP I Sbjct: 549 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 608 Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290 P N V + V+L C A P SWF+ + V V + VDG LR+ Sbjct: 609 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 663 Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335 Q DAG Y CV SN GL ++ P L P ++ PVR P Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 723 Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394 + W KDG + PG G L +A G YSC +++G V Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 783 Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453 +V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++ Sbjct: 784 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 839 Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487 L + + GH+ C A N N+ V Sbjct: 840 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876 Score = 63.9 bits (154), Expect = 8e-10 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142 R +LQ G SL I +D G Y+C + E++ V + V S P FQ Sbjct: 2983 RHQLQNG-SLTIRRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3032 Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202 P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092 Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227 Y C A + GSAT L+V G P Sbjct: 3093 TYDCVAHNLLGSATARAFLVVRGEP 3117 Score = 57.8 bits (138), Expect = 6e-08 Identities = 97/438 (22%), Positives = 159/438 (36%), Gaps = 70/438 (15%) Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP-AVLEVQE 150 LQI + ED G Y C V L + + H+ V PP + P A + V+E Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLAEVGVKE 1366 Query: 151 LEP-----VTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204 ++ +TL C + P P + W G+ + QV + L+I+ + SG Y Sbjct: 1367 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1426 Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244 C A++ G +L+ PP+ S + + Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486 Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303 L C A P +W++++ + V +L G L++ + ++AG Y+C Sbjct: 1487 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1541 Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344 SN +L PP +TV V ++CP N P+ +SW ++ Sbjct: 1542 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1600 Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403 G L P +G ++ ++ Y C N G+A RV + PP Sbjct: 1601 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1656 Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460 E+ + + +PC P P V+W K + L +V +L L Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716 Query: 461 TKEAHGHWECSASNAVAR 478 G + C A NA R Sbjct: 1717 RLSDSGMYTCEALNAAGR 1734 >gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] Length = 1215 Score = 124 bits (311), Expect = 5e-28 Identities = 141/499 (28%), Positives = 204/499 (40%), Gaps = 83/499 (16%) Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88 V+ GE VL C+ +G PP VI W R G + + Sbjct: 590 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 625 Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145 +G+S L+I + D G Y CR + E A+ + L V PQ E P V Sbjct: 626 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 678 Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198 V+ L C A G P P VTW+ G LG G+G Q +G L V Sbjct: 679 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737 Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256 Y C+A + G +L+V G PP I V Q VSL C A Sbjct: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797 Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310 W +D L P R I DGSL L + AG Y+CV +N G H Sbjct: 798 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851 Query: 311 -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359 P+A+ ++T +P + C V + P ++WTK+ AL + P ++ Sbjct: 852 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 909 Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE------EYF 413 EG+L+IA + G Y CT N++G + S R+ + P + Sbjct: 910 KEGTLLIAQPSAQDAGAYVCTATNTVGFS--SQEMRLSVNTKPRIHMNGSRNANVPLQVT 967 Query: 414 QEVGRELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWEC 470 + G E+ + C A+G PPP+V+WTK R + + + + SL L + GH+EC Sbjct: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027 Query: 471 SASNAVARVATSTNVYVLG 489 +ASN ++++ YVLG Sbjct: 1028 TASNP---AGSASHRYVLG 1043 Score = 97.1 bits (240), Expect = 9e-20 Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%) Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210 +P+ + C S LP RG+ LG+ + + N + I R + G Y C A S Sbjct: 325 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383 Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268 G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 436 Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324 R+ P RV L D SL + P D G Y CV SN AS +L V P Sbjct: 437 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 492 Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367 V + C + P +SW+++ +ALQ D +G+LII Sbjct: 493 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 549 Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427 + EDA G YSC N +GT T L P + VG E ++ C A Sbjct: 550 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605 Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487 G PPP V W + G + + S+ L + + G + C A N + + + V Sbjct: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665 Query: 488 LGTSPHV 494 G +P + Sbjct: 666 -GHAPQL 671 Score = 96.7 bits (239), Expect = 1e-19 Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%) Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61 +S+ GR K ++V +V GE+ VL C +L G P + + W+R Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 435 Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121 R+ P GRV SL+I G+ D G Y+C Sbjct: 436 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 473 Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178 ANG + V L V PQ + Q +E V + C A G P PH++W + L Sbjct: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 531 Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237 Q ++ V GTL I+ V +G Y+CQA++ G+ L PP + Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591 Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297 V ++ L C A P W++ + + L P G LR+ A Q DAG Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 644 Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341 YTC N L SA L V L ++ C PP V+W Sbjct: 645 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 702 Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396 + DG+ L L G Q G L + Y C N G V Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762 Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453 APP E G+ + +PC G P P W K GR L + + ++ Sbjct: 763 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821 Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502 SL L +E G + C A+N + V T+ H +TN V A Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 876 Score = 53.5 bits (127), Expect = 1e-06 Identities = 36/105 (34%), Positives = 54/105 (51%), Gaps = 7/105 (6%) Query: 128 VHLTVNSPPQFQ------ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ 181 + L+VN+ P+ P + + E VTL C A+GSP P VTW + + Sbjct: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001 Query: 182 GQVQV-QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG 225 + + +G+LR+ +V+ G SG Y C AS+ GSA+H L V G Sbjct: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046 >gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo sapiens] Length = 1386 Score = 122 bits (306), Expect = 2e-27 Identities = 268/1142 (23%), Positives = 402/1142 (35%), Gaps = 203/1142 (17%) Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87 +VV GE VL C +PP G P V W + G L + GR+ + Sbjct: 174 NVVVAVGEPAVLEC--VPPRGHPEPSV-SWRKDGARLK--------------EEEGRITI 216 Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLE 147 + G + L+ D G Y C + + + V P F P + Sbjct: 217 RGGKLMMSHTLK-SDAGMYVCVASNMAGE------RESAAAEVMVLERPSFLRRPVNQVV 269 Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207 + + PVT C +G P P + W+ +L G+ +++ + +L I V G YTC Sbjct: 270 LADA-PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDH-SLWIGHVSAEDEGTYTCV 327 Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267 A ++ G A + L V PP +V P++ + V+ C + P + W ++ Sbjct: 328 AENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF-WQKEGSQ 386 Query: 268 V--FHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC--------VPSNGLLHPPSAS- 314 V F LQP R V G L + A Q DAG Y C + + LL AS Sbjct: 387 VLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASL 446 Query: 315 -----------AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 362 A T++ V + C V NP V W KDG+ LQ D + G Sbjct: 447 DGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPS-VRWKKDGQWLQGDDLQ-FKTMANG 504 Query: 363 SLIIALGNEDALGEYSCTPYNSLGTA------------GPSPVTRVLLKAPPAFIERPKE 410 +L IA E +G YSC +S G A G SP +PP P + Sbjct: 505 TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG---APSQ 561 Query: 411 EYFQEVGRELLI----PCSAQG-----------DPPPVVSWTKVGRGLQGQAQVDSNSSL 455 E+ + + P G P +W V G+Q + S Sbjct: 562 PVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSG--- 618 Query: 456 ILRPLT-----KEAHGHWECSASNAVARVATSTNVYVLGTSPH----------------- 493 L+P T A G W S + V S V +SP Sbjct: 619 -LQPNTIYLFLVRAVGAWGLSEPSPV-----SEPVRTQDSSPSRPVEDPWRGQQGLAEVA 672 Query: 494 VVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHL 553 V +V P+ VSW +Q F V + P+ + L P + + Sbjct: 673 VRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAG--PEGGSWTMLDLQSPSQQSTV 730 Query: 554 LVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612 L GL P TQ Q V AQ + G G S + S PE P+ PP+ Sbjct: 731 L-RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS----------------GPPQ 773 Query: 613 GLVAVRTPRG---VLLHWDPPELVPKRLDGYVLEGR---QGSQGWEVLDPAVAGTETELL 666 G+ G + + W+PP +P + +G + E + G++ L+ + AG + Sbjct: 774 GVAVALGGDGNSSITVSWEPP--LPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAM 831 Query: 667 VPGLIKDVLYEFRLVAFAGSFVSDPSNTANVS-------TSGLEVYPS-RTQLPGLLPQP 718 + GL+ +LY + A + V PS V GLEV +L +L +P Sbjct: 832 LRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREP 891 Query: 719 VLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALG 778 G C A+L+ + A RR++++ F+ T + P + G Sbjct: 892 AFLAGSGAAC---GALLLGLCAALYW------RRKQRKELSHYTASFAYTPAVSFPHSEG 942 Query: 779 SGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFV 838 S + L +P L S W P+ +PS +P S P P PD R+ Sbjct: 943 LSGASSRPPMGLGPAPYSWLADS--WPHPSRSPSAQ-EPRGS--CCPSNP---DPDDRYY 994 Query: 839 MGPTVAAPQERSGREQAEPR--------TPAQRLARSFDCS-SSSPSG--------APQP 881 ++ ++ R A P PA ++F PSG AP Sbjct: 995 NEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPE 1054 Query: 882 LCIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930 D PV P P LP P P + LS E ++G P EE Sbjct: 1055 WSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCE-LSCLEGPEEELEGSSEP-EE 1112 Query: 931 PSPAAPPDYMDTRRCPTSSFLRSP---ETPPVSPRESLPGAVVGAGATAEPPYTALADWT 987 P P T + L +P ETP +P + +PP Sbjct: 1113 WCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPH 1172 Query: 988 LRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPE 1047 L + +P +P P L+ G A A +LSP+P +++ ++ Sbjct: 1173 LHQ--MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGR 1230 Query: 1048 RW 1049 W Sbjct: 1231 TW 1232 Score = 118 bits (296), Expect = 3e-26 Identities = 153/596 (25%), Positives = 240/596 (40%), Gaps = 90/596 (15%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F+++P V+ V EP L CV RG P P V+W+ G L + +G++ ++ G L + Sbjct: 168 FRQSPGNVV-VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226 Query: 197 ERGSSGVYTCQASSTEGS-ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G+Y C AS+ G + A +++VL P + P N V A V+ C + P Sbjct: 227 LKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 W +++ + R I D SL + +D G YTCV N + AS Sbjct: 287 P-RLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENS-VGRAEASG 339 Query: 316 YLTV-------------LCMPG---VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---- 355 L+V + PG +C + NPP + W K+G + L FP Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPA-IFWQKEGSQVLL--FPSQSLQ 396 Query: 356 ----WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV----LLKAPPAFIER 407 +S G L I G Y C + G+ + + L PP ++ Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG 456 Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQG---QAQVDSNSSLILRPLTKEA 464 P + +G + +PC G+P P V W K G+ LQG Q + +N +L + + + Sbjct: 457 PANQTL-VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMD 515 Query: 465 HGHWECSASNAVARVATSTNVYV---LGTSPHVVTNVS----------VVALPKGA-NVS 510 G + C A ++ S + + G SP T S V + K + ++ Sbjct: 516 MGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575 Query: 511 WEPGFDGGYLQRFSV--WYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568 W+P G V ++P A + W ++A V V GLQP+T Y F V Sbjct: 576 WKPNPQTGAAVTSYVIEAFSPAA------GNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629 Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL--VAVRT------- 619 A G S + E + T ++P P + P +GL VAVR Sbjct: 630 RAVGAWGLSEPSPV----SEPVRTQDSSPSRP---VEDPWRGQQGLAEVAVRLQEPIVLG 682 Query: 620 PRGVLLHW---DPPELVPKRLDGYVLEGRQGSQGWEVLD---PAVAGTETELLVPG 669 PR + + W P +LV + + G +G W +LD P+ T L PG Sbjct: 683 PRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGG-SWTMLDLQSPSQQSTVLRGLPPG 737 Score = 117 bits (292), Expect = 8e-26 Identities = 156/621 (25%), Positives = 244/621 (39%), Gaps = 72/621 (11%) Query: 118 PEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDL 177 P D NGS V ++ P+ E PP +L V EP TL C A G P P++ W G + Sbjct: 47 PGDPSLNGSRVG-PEDAMPRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYKNGARV 104 Query: 178 GQGQ-----GQVQVQNGTLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLG 225 + ++ + +G L R+ G GVYTC A + G+A +A+ + + Sbjct: 105 ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL 164 Query: 226 PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS 285 P N V + L C + SW +D + + R+ I G Sbjct: 165 RDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA---RLKEEEGRITIR-GGK 220 Query: 286 LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR----ANPPLLF--- 338 L + T DAG Y CV SN SA+A + VL P +R PV A+ P+ F Sbjct: 221 LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCE 280 Query: 339 --------VSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390 + W K+ L ++ ++ SL I + + G Y+C NS+G A Sbjct: 281 VKGDPPPRLRWRKEDGELPTGRY---EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEA 337 Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG--------RG 442 S V PP + +P+++ G + C +G+PPP + W K G + Sbjct: 338 SGSLSV--HVPPQLVTQPQDQ-MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQS 394 Query: 443 LQ--GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-----PHVV 495 LQ G+ V L + + + G++ C A + + + + G S P ++ Sbjct: 395 LQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL 454 Query: 496 TNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLV 555 + L G++V W P G Q W K + D + L + Sbjct: 455 QGPANQTLVLGSSV-WLPCRVTGNPQPSVRW----KKDGQWLQGDDLQFKTMANGT-LYI 508 Query: 556 PGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE-IPPPLSPPRGL 614 +Q +S +A++ G +S L E +P PPTE PP +P + + Sbjct: 509 ANVQEMDMGFYSCVAKSSTGEATWSG-WLKMREDWGVSPD----PPTEPSSPPGAPSQPV 563 Query: 615 VAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQG--WE-VLDPAVAGTETELLVPGLI 671 V T + L W P + YV+E + G W V D T T V GL Sbjct: 564 VTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHT---VSGLQ 620 Query: 672 KDVLYEFRLVAFAGSFVSDPS 692 + +Y F + A +S+PS Sbjct: 621 PNTIYLFLVRAVGAWGLSEPS 641 >gi|222352127 sidekick 2 [Homo sapiens] Length = 2172 Score = 120 bits (300), Expect = 1e-26 Identities = 157/603 (26%), Positives = 239/603 (39%), Gaps = 102/603 (16%) Query: 154 VTLRCVARGSPLP--HVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA--- 208 VTL CVA PL H+ WK G L G + N L I +G Y C+A Sbjct: 233 VTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAVLR 289 Query: 209 SSTEGSATHATQLLVLGPPVIVVPP-KNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267 SS+ S L VL PP V P ++ T + V + C A+ P + +W++D Sbjct: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP-SITWYKDAA- 347 Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCM-PGVI 326 V + +L R R DG L++ PDD G + C N S YL V + P + Sbjct: 348 VVEVEKLT-RFRQRNDGGLQISGLVPDDTGMFQCFARNAA-GEVQTSTYLAVTSIAPNIT 405 Query: 327 RCPV---------------RANPPLLFVSWTKDGKALQLD--KFPGWSQGTEGSLIIALG 369 R P+ + P ++W K + L + P ++ GSL+I+ Sbjct: 406 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465 Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429 + G Y+C NS G S V + I +P ++ G + + C D Sbjct: 466 HISDAGTYTCLATNSRGVDEASADLVVWARTR---ITKPPQDQSVIKGTQASMVCGVTHD 522 Query: 430 PPPVVS--WTKVGRGLQGQA----QVDSNSSLILRPLTKEAHGHWECSASNAVARVATST 483 P + W K G L ++ ++D N SL + G + C +A + S Sbjct: 523 PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582 Query: 484 NVYV--LGTSP-HVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540 ++ V L +P H V +S V + N++W FDG +PL + M + Sbjct: 583 HLRVRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGN---------SPLIRYILEMSEN 632 Query: 541 ---WVSLAVPVG--AAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV--LSAPEGLPTT 593 W L V A + V GL P YQF + A N +G G FS+ +S PE Sbjct: 633 NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE----- 687 Query: 594 PAAPGLPPTEIPPPLSPPRGLVAV-RTPRGVLLHWDPPELVPKR--LDGYVLEG-----R 645 PP +PP+ ++A RT + +++ W PP + L GY++ Sbjct: 688 -----------EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP 736 Query: 646 QGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVY 705 G Q + D V LL+ LI YE + A+ +++GL VY Sbjct: 737 VGYQFKNITDADV----NNLLLEDLIIWTNYEIEVAAY--------------NSAGLGVY 778 Query: 706 PSR 708 S+ Sbjct: 779 SSK 781 Score = 89.0 bits (219), Expect = 2e-17 Identities = 129/541 (23%), Positives = 202/541 (37%), Gaps = 72/541 (13%) Query: 102 DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVAR 161 D G+YEC +P G++ L+V PPQF + P + + + V + C A+ Sbjct: 278 DAGYYECEAVLRSSSVPS--VVRGAY--LSVLEPPQFVKEPERHITAEMEKVVDIPCQAK 333 Query: 162 GSPLPHVTWKLRGKDLGQGQGQV-----QVQNGTLRIRRVERGSSGVYTCQASSTEGSAT 216 G P P +TW KD + + Q +G L+I + +G++ C A + G Sbjct: 334 GVPPPSITWY---KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390 Query: 217 HATQLLVLG-PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQ 275 +T L V P I P +STV V LAC P +W + + S Sbjct: 391 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITWQKGERILASGSVQL 449 Query: 276 PRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIR-------- 327 PR L GSL + T DAG YTC+ +N ASA L V + + Sbjct: 450 PRFTPLESGSLLISPTHISDAGTYTCLATNS-RGVDEASADLVVWARTRITKPPQDQSVI 508 Query: 328 --------CPVRANPPL-LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYS 378 C V +P + + W KDG L + P GSL I+ +G Y+ Sbjct: 509 KGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYT 568 Query: 379 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA--QGDPPPV--- 433 C ++ G S RV + P E P R + + + G+ P + Sbjct: 569 CRVISAGGNDSRSAHLRV--RQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI 626 Query: 434 -------VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR--VATSTN 484 WT + + +A +S+ ++ L + A N V + + T Sbjct: 627 LEMSENNAPWTVLLASVDPKA-----TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681 Query: 485 VYVLGTSPHVVTNVSVVA---LPKGANVSWEP-------GFDGGYLQRFSVWYTPLAKRP 534 L P +V+A + + W+P G GY+ R+ + P+ + Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741 Query: 535 DRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLS-APEGLPTT 593 + +LL+ L T Y+ V A N G G +S V +G+PT Sbjct: 742 KNI--------TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793 Query: 594 P 594 P Sbjct: 794 P 794 Score = 85.1 bits (209), Expect = 4e-16 Identities = 131/559 (23%), Positives = 207/559 (37%), Gaps = 72/559 (12%) Query: 164 PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLV 223 P P VTW G+ + TL I +G Y QA + + +Q + Sbjct: 141 PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 200 Query: 224 L------GP-----PVIVVPPKNSTVNA-SQDVSLACHAEAYP-ANLTYSWFQDNINVFH 270 L GP P I++PPKN++V A + +V+L C A A P L W +D + + Sbjct: 201 LTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL-- 258 Query: 271 ISRLQPRVRILVDGSLRLLATQP--DDAGCYTCVPSNGLLHPPSA--SAYLTVLCMPGVI 326 + D + RL P DAG Y C PS AYL+VL P + Sbjct: 259 -------SGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311 Query: 327 R-----------------CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 369 + C + PP ++W KD ++++K + Q +G L I+ Sbjct: 312 KEPERHITAEMEKVVDIPCQAKGVPP-PSITWYKDAAVVEVEKLTRFRQRNDGGLQISGL 370 Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429 D G + C N+ G S V AP I R + G +++ C G Sbjct: 371 VPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMSVVLACETSGA 428 Query: 430 PPPVVSWTKVGRGL-QGQAQVD-----SNSSLILRPLTKEAHGHWECSASNAVARVATST 483 P P ++W K R L G Q+ + SL++ P G + C A+N+ S Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488 Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVS 543 ++ V+ + ++ KG S G V + P + + W Sbjct: 489 DL-VVWARTRITKPPQDQSVIKGTQASMVCG----------VTHDPRV----TIRYIWEK 533 Query: 544 LAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE 603 +G L + S +G+ ++ V+SA + L + Sbjct: 534 DGATLGTESHPRIRLDRNGSLHISQTWSGDIGT--YTCRVISAG---GNDSRSAHLRVRQ 588 Query: 604 IPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTET 663 +P P ++ R + L W P L Y+LE + + W VL +V T Sbjct: 589 LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT 648 Query: 664 ELLVPGLIKDVLYEFRLVA 682 + V GL+ Y+FRL A Sbjct: 649 SVTVKGLVPARSYQFRLCA 667 Score = 80.1 bits (196), Expect = 1e-14 Identities = 75/277 (27%), Positives = 119/277 (42%), Gaps = 21/277 (7%) Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136 ++ + + R R + LQI GL +D G ++C F E + +L V S Sbjct: 349 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC---FARNAAGEVQTS----TYLAVTSIA 401 Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQV----QVQNGTLR 192 P V + V L C G+P P +TW+ + L G Q+ +++G+L Sbjct: 402 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461 Query: 193 IRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEA 252 I +G YTC A+++ G + L+V I PP++ +V S+ C Sbjct: 462 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521 Query: 253 YP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHP 310 P + Y W +D + + PR+R+ +GSL + T D G YTC V S G Sbjct: 522 DPRVTIRYIWEKDGATLG--TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG--GN 577 Query: 311 PSASAYLTVLCMPGVIRCPVRANPPL----LFVSWTK 343 S SA+L V +P PV + + ++WTK Sbjct: 578 DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614 Score = 52.8 bits (125), Expect = 2e-06 Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 16/122 (13%) Query: 509 VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568 +SWEPG DG R+ YT + S +V A+ +V L+P T Y+F V Sbjct: 1420 LSWEPGSDGLSPVRY---YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRV 1476 Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628 A N +G FSE E L T AAP PT + V T VL+ W Sbjct: 1477 KATNDIGDSEFSE----ESESLTTLQAAPDEAPTILS---------VTPHTTTSVLIRWQ 1523 Query: 629 PP 630 PP Sbjct: 1524 PP 1525 Score = 42.7 bits (99), Expect = 0.002 Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 41/200 (20%) Query: 508 NVSWE-PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH-----LLVPGLQPH 561 NVSWE P F G L+ + + Y P + D VS V V L V L Sbjct: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPV------DGVSKIVTVDVKGNSPLWLKVKDLAEG 1794 Query: 562 TQYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620 Y+F + A+ V + P EG P P P + VR Sbjct: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVP-----------------IIVRYS 1837 Query: 621 RGVLLHWDPPELVPKRLDGYVLEGRQGSQG-WEVL---DPAVAGTET---ELLVPGLIKD 673 + +HW + + YV+E R +G W++L P + T ++L PG Sbjct: 1838 SAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPG---- 1893 Query: 674 VLYEFRLVAFAGSFVSDPSN 693 V Y+FR++A PS+ Sbjct: 1894 VSYDFRVIAVNDYGFGTPSS 1913 Score = 37.7 bits (86), Expect = 0.064 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 21/131 (16%) Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSE--IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614 GL+P + Y F + AQ + G G +E +V + P P+ P + ++ Sbjct: 1364 GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDV---------- 1413 Query: 615 VAVRTPRGVLLHWDPPE--LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLI 671 R VLL W+P L P R Y ++ R+ G W + +V+ + +V L Sbjct: 1414 ----RARSVLLSWEPGSDGLSPVRY--YTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467 Query: 672 KDVLYEFRLVA 682 Y+FR+ A Sbjct: 1468 PFTSYKFRVKA 1478 Score = 34.7 bits (78), Expect = 0.54 Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 17/142 (11%) Query: 555 VPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614 + L+ T+Y+ V A N +GSGP+S+ V+ T + P PT + Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR-----TRESVPSSGPTNVS--------- 1207 Query: 615 VAVRTPRGVLLHW-DPPELVPKRLD-GYVLEGRQGSQGWEVLDPAVAGTET-ELLVPGLI 671 T +L+ W + PE L GY + ++ + V G + + GL Sbjct: 1208 ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 1267 Query: 672 KDVLYEFRLVAFAGSFVSDPSN 693 K VLYE +++AF PS+ Sbjct: 1268 KYVLYEVQVLAFTRIGDGSPSH 1289 Score = 34.3 bits (77), Expect = 0.71 Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 20/146 (13%) Query: 492 PHVVTNVSVVAL-PKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWV---SLAVP 547 P TN+ + + P+ + + PG+DG S W +W+ L+ Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGK--TSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050 Query: 548 VGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPP 607 A + VP L P T Y F + N +G+ P P+ P+ + + PP Sbjct: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSP------------PSQPSRK-IQTLQAPPD 1097 Query: 608 LSPPRGLVAVRTPRGVLLHWDP-PEL 632 ++P + + + L W P PE+ Sbjct: 1098 MAPANVSLRTASETSLWLRWMPLPEM 1123 Score = 34.3 bits (77), Expect = 0.71 Identities = 47/159 (29%), Positives = 62/159 (38%), Gaps = 21/159 (13%) Query: 558 LQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAV 617 L +T Y SV A N G GP S P T AAP P + L Sbjct: 1690 LTGYTAYMVSVAAFNAAGDGP-----RSTPTQGQTQQAAPSAPSSVKFSEL--------- 1735 Query: 618 RTPRGVLLHWDPPELVPKRLDGY--VLEGRQGSQG-WEVLDPAVAG-TETELLVPGLIKD 673 T V + W+ P+ L+GY V E G +++ V G + L V L + Sbjct: 1736 -TTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794 Query: 674 VLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLP 712 V Y FR+ A +F P ANV+T E P +P Sbjct: 1795 VTYRFRI--RAKTFTYGPEIEANVTTGPGEGAPGPPGVP 1831 Score = 33.9 bits (76), Expect = 0.93 Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 25/184 (13%) Query: 503 LPKGANVSW-EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561 L VSW EPG G L + + + + R+ H +P V GL Sbjct: 907 LDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTH-----YLPNVTLEYRVTGLTAL 961 Query: 562 TQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621 T Y V A G G S +S+ G+P P PG PPT + ++ PR Sbjct: 962 TTYTIEVAAMTSKGQGQVSASTISS--GVP--PELPG-PPTNLG---------ISNIGPR 1007 Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQGSQG----WEVLDPAVAGTETELL-VPGLIKDVLY 676 V L + P + +++E + G G W ++ + + VP L Y Sbjct: 1008 SVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067 Query: 677 EFRL 680 FR+ Sbjct: 1068 SFRM 1071 Score = 31.2 bits (69), Expect = 6.0 Identities = 49/181 (27%), Positives = 68/181 (37%), Gaps = 23/181 (12%) Query: 325 VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ---GTEGSLIIALGNEDALGEYSCTP 381 VIR P A+ P V+W +DG+ K P S+ E +L+I G Y Sbjct: 131 VIRAPRIASFPQPQVTWFRDGR-----KIPPSSRIAITLENTLVILSTVAPDAGRYYVQA 185 Query: 382 YNSLG----TAGPSPVTRVLLKAP-----PAFIERPKEEYFQEVGRELLIPCSAQGDP-- 430 N T+ P +T + P P I PK E+ + C A P Sbjct: 186 VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLI 245 Query: 431 PPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSA---SNAVARVATSTNVYV 487 + W K G L G D N L + T G++EC A S++V V + V Sbjct: 246 KLHIIWKKDGVLLSGGIS-DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304 Query: 488 L 488 L Sbjct: 305 L 305 >gi|157311649 neogenin homolog 1 [Homo sapiens] Length = 1461 Score = 120 bits (300), Expect = 1e-26 Identities = 179/714 (25%), Positives = 268/714 (37%), Gaps = 116/714 (16%) Query: 25 EVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84 E V + G SV+L C A P IEW + G L + + D R Sbjct: 58 EPVDTLSVRGSSVILNCS----AYSEPSPKIEWKKDGTFLNL----------VSDD---R 100 Query: 85 VRLQKGASLQIEGL-----RVEDQGWYEC--RVFFLDQHIPEDDFANGSWVHLTVNSPPQ 137 +L SL I + D+G+Y+C V L I L V P+ Sbjct: 101 RQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRT-------AKLIVAGLPR 153 Query: 138 FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197 F P V L C +P V W+ + L +++ +G L I Sbjct: 154 FTSQPEPS-SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT 212 Query: 198 RGSSGVYTCQASST-EGSATHATQLLVLGPP------VIVVPPKNSTVNASQDVSLACHA 250 G G+Y C S + +L VL P V + P QDV L C A Sbjct: 213 EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVA 272 Query: 251 EAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310 P T W ++ + S R+ +L GSL + DDAG Y C+ NG Sbjct: 273 SGLPTP-TIKWMKNEEALDTES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGN-ET 328 Query: 311 PSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGK-ALQLDKFP 354 A A LTV P ++ P P V W K+G + D F Sbjct: 329 IEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK 388 Query: 355 GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA---FIERPKEE 411 + L + +E G Y C N +G A +L AP P++ Sbjct: 389 IVKEHNLQVLGLVKSDE---GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDV 445 Query: 412 YFQEVGRELL-----IPCS-AQGDPPPV-VSWTKVGRGLQ--------GQAQVDSNSSL- 455 V + P S GD V +TK G + G+ QV + + Sbjct: 446 VASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMP 505 Query: 456 ----ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSW 511 I R + + HG E S+A RV T V + G +P++ + A P V+W Sbjct: 506 ATVYIFRVMAQNKHGSGE---SSAPLRVETQPEVQLPGPAPNLR---AYAASPTSITVTW 559 Query: 512 EPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570 E G G +Q + ++Y + K D+ V V + + GL+ +T+Y F V+A Sbjct: 560 ETPVSGNGEIQNYKLYY--MEKGTDKEQD------VDVSSHSYTINGLKKYTEYSFRVVA 611 Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630 NK G G +S P+ T + P+ P LS + VR + +++HW PP Sbjct: 612 YNKHGPG------VSTPDVAVRTLSDV---PSAAPQNLS-----LEVRNSKSIMIHWQPP 657 Query: 631 ELVPK--RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682 + ++ GY + R+ S+ +V + V+GT+ L+ GL + Y FR+ A Sbjct: 658 APATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711 Score = 107 bits (267), Expect = 7e-23 Identities = 150/607 (24%), Positives = 225/607 (37%), Gaps = 84/607 (13%) Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK--DLGQGQGQVQVQNGTL 191 +P F P L V+ V L C A P P + WK G +L + + +G+L Sbjct: 51 TPFYFLVEPVDTLSVRG-SSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSL 109 Query: 192 RIRRV-----ERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDV 244 I V + G Y C A+ S + +L+V G P P+ S+V A + Sbjct: 110 FISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNA 169 Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304 L C A W Q+ + L RV L G L + D G Y CV Sbjct: 170 ILNCEVNADLVPFV-RWEQNRQPLL----LDDRVIKLPSGMLVISNATEGDGGLYRCVVE 224 Query: 305 NG------------LLHPPSASAYLTVLCMPG----------VIRCPVRANPPLLFVSWT 342 +G +L P + L L P V+ C V + P + W Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWM 283 Query: 343 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 402 K+ +AL + GSL I+ ED G Y C N G + ++A P Sbjct: 284 KNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN--GNETIEAQAELTVQAQP 341 Query: 403 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPL 460 F+++P Y E +++ C G P P V W K G + ++ +L + L Sbjct: 342 EFLKQPTNIYAHE-SMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 400 Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN--------VSVVALPKGANVSWE 512 K G ++C A N V + +L +P V+ + + ++W Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460 Query: 513 -PGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570 P D G +SV+YT +R+ + G + + L P T Y F V+A Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVEN-----TSHPGEMQVTIQNLMPATVYIFRVMA 515 Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630 QNK GSG SAP + T P ++P P R A +P + + W+ P Sbjct: 516 QNKHGSGE-----SSAPLRVETQ------PEVQLPGPAPNLRAYAA--SPTSITVTWETP 562 Query: 631 ELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--A 684 + Y L +G Q +V + + GL K Y FR+VA+ Sbjct: 563 VSGNGEIQNYKLYYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKH 615 Query: 685 GSFVSDP 691 G VS P Sbjct: 616 GPGVSTP 622 Score = 57.0 bits (136), Expect = 1e-07 Identities = 125/563 (22%), Positives = 218/563 (38%), Gaps = 105/563 (18%) Query: 208 ASSTEGSATHA--TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265 A++ GSA + + P +V P ++ V L C A + P+ W +D Sbjct: 32 AAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSP-KIEWKKDG 90 Query: 266 INVFHISRLQPRVRILVDGSLRLLAT------QPDDAGCYTCVPS-NGLLHPPSASAYLT 318 + +S R ++L DGSL + +PD+ G Y CV + L S +A L Sbjct: 91 TFLNLVS--DDRRQLLPDGSLFISNVVHSKHNKPDE-GYYQCVATVESLGTIISRTAKLI 147 Query: 319 VLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQLD----KFPGWSQ 358 V +P ++ C V A+ + FV W ++ + L LD K P Sbjct: 148 VAGLPRFTSQPEPSSVYAGNNAILNCEVNADL-VPFVRWEQNRQPLLLDDRVIKLPS--- 203 Query: 359 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPP--------AFIERPK 409 G L+I+ E G Y C + + GP + V LK P F+++P Sbjct: 204 ---GMLVISNATEGDGGLYRCV----VESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256 Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQ----VDSNSSLILRPLTKEAH 465 + +G+++++PC A G P P + W K L ++ + + SL + +T++ Sbjct: 257 P-LVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDA 315 Query: 466 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSV 525 G + C A N + + V P + + + + ++ +E G Sbjct: 316 GTYFCIADNGNETIEAQAELTV-QAQPEFLKQPTNIYAHESMDIVFECEVTGK------- 367 Query: 526 WYTPLAKRPDRMHHDWV---SLAVP------VGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576 TP K WV + +P V +L V GL + + +A+N +G+ Sbjct: 368 -PTPTVK--------WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418 Query: 577 GPF-SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP- 634 +++++ L PA G P P +P + ++ + R + L W P P Sbjct: 419 AQAGAQLII-----LEHAPATTG------PLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467 Query: 635 -KRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSN 693 L V ++G V + + G E ++ + L+ +Y FR++A + S Sbjct: 468 GDNLTYSVFYTKEGIARERVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526 Query: 694 TANVSTSGLEVYPSRTQLPGLLP 716 V T QLPG P Sbjct: 527 PLRVETQ------PEVQLPGPAP 543 Score = 52.4 bits (124), Expect = 3e-06 Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 35/211 (16%) Query: 24 PEVVS----------VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73 PEV+S +V G+ VVL C A P I+W++ Sbjct: 243 PEVISDLVFLKQPSPLVRVIGQDVVLPC----VASGLPTPTIKWMK-------------N 285 Query: 74 SPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN 133 +D + R+ L G SL+I + +D G Y C ++ I + LTV Sbjct: 286 EEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-------AQAELTVQ 338 Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI 193 + P+F + P + + ++ + C G P P V W G + V+ L++ Sbjct: 339 AQPEFLKQPTNIYAHESMD-IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQV 397 Query: 194 RRVERGSSGVYTCQASSTEGSATHATQLLVL 224 + + G Y C A + G+A QL++L Sbjct: 398 LGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428 Score = 40.0 bits (92), Expect = 0.013 Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 5/113 (4%) Query: 473 SNAVARVATSTNVYVLGTSPHV-VTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPL 530 S+ + A T ++ TSP VT VS PK V+W+P + G + + ++Y+ Sbjct: 938 SSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTD 997 Query: 531 AKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583 HDWV V + L T Y F + A+N G GP SE V Sbjct: 998 VNAEI---HDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047 Score = 39.3 bits (90), Expect = 0.022 Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 24/136 (17%) Query: 554 LVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRG 613 LV GL+P+T Y+FSV+ S +S L P SPP+ Sbjct: 916 LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL---------------VPTSPPKD 960 Query: 614 LVAVR---TPRGVLLHWDPPELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELL 666 + V P+ ++++W PP ++ GY++ + W V++P V G Sbjct: 961 VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDW-VIEP-VVGNRLTHQ 1018 Query: 667 VPGLIKDVLYEFRLVA 682 + L D Y F++ A Sbjct: 1019 IQELTLDTPYYFKIQA 1034 >gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo sapiens] Length = 1248 Score = 117 bits (294), Expect = 5e-26 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72 ++++GA K V V GESVVL C+ PP PL + W+ L Sbjct: 125 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 172 Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126 I D RV + + +L + D Y C F + Q P D + Sbjct: 173 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 227 Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186 + F + L + +P+ L C+A G P P + W + + Q Sbjct: 228 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 287 Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246 N TL++ +V G Y C A ++ GSA HA + V P + P++ + L Sbjct: 288 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 347 Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305 C + P +W + I V +++ Q + RI G+L L QP D C N Sbjct: 348 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 404 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345 GLL A+AY+ V+ +P I P+ V W +DG Sbjct: 405 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 461 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 LQ ++F ++ GT G I L D G Y C N + + + +K Sbjct: 462 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 516 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459 + P+ ++ G + C A DP P ++W GR LQ D + L++ Sbjct: 517 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 575 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516 L G++ C AS + V + + V+G+ P +V + + VSW P D Sbjct: 576 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 635 Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575 ++++ + + P++ W SL G L P+ Y F V A NK G Sbjct: 636 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 691 Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635 G S + E + T AAP P ++ + +V P + W+ P++ Sbjct: 692 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 743 Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672 Y ++ R QG++G W+ V DP + + T VP IK Sbjct: 744 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 782 Score = 90.1 bits (222), Expect = 1e-17 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%) Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214 L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + + Sbjct: 441 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 500 Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273 T L V I P+++ V+ C A P+ + +W D ++ + Sbjct: 501 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 560 Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333 + DG L + + D G Y+CV S L + A L V+ PG + V ++ Sbjct: 561 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 617 Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371 LL VSW+ + K + +K+ G G + S + L + Sbjct: 618 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 676 Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426 + T N G PSPV+ ++ A + P + + G E ++I Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 734 Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481 + P V V W G Q Q+ S+ L++ + + A N+ + Sbjct: 735 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 794 Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532 T Y P + + + + + V W P G+L+ ++V W + Sbjct: 795 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 854 Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592 + + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P Sbjct: 855 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 914 Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646 P A L ++ +LL W PP L GYVL EG + Sbjct: 915 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 958 Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682 G + + DP + L P L Y F+L A Sbjct: 959 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 990 Score = 68.6 bits (166), Expect = 3e-11 Identities = 95/410 (23%), Positives = 157/410 (38%), Gaps = 61/410 (14%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQVQN 188 PP E P L V + ++L+C A G P W G ++LG Q + Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-SPHS 87 Query: 189 GTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST----VN 239 G+ I + G+Y C AS+ G+A +H +L+ G P PK + V Sbjct: 88 GSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVE 144 Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQPDD 295 + V L C+ L W N + HI + RV + +G+L L + D Sbjct: 145 EGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDNHSD 201 Query: 296 AGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIRCPV 330 C+ P LL P ++S++L L P V+ C + Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC-I 260 Query: 331 RANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390 P + W + + D+ + + ++ +G ED GEY C NSLG+A Sbjct: 261 AEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGSA-- 316 Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD 450 V ++A P ++ +P+ + G + C QG P P V+W G ++ A+ Sbjct: 317 RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ 375 Query: 451 ----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496 +LIL + +C A N + + +YV+ ++T Sbjct: 376 KYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 425 >gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo sapiens] Length = 1253 Score = 117 bits (294), Expect = 5e-26 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72 ++++GA K V V GESVVL C+ PP PL + W+ L Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177 Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126 I D RV + + +L + D Y C F + Q P D + Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232 Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186 + F + L + +P+ L C+A G P P + W + + Q Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292 Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246 N TL++ +V G Y C A ++ GSA HA + V P + P++ + L Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352 Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305 C + P +W + I V +++ Q + RI G+L L QP D C N Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345 GLL A+AY+ V+ +P I P+ V W +DG Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 LQ ++F ++ GT G I L D G Y C N + + + +K Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459 + P+ ++ G + C A DP P ++W GR LQ D + L++ Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516 L G++ C AS + V + + V+G+ P +V + + VSW P D Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640 Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575 ++++ + + P++ W SL G L P+ Y F V A NK G Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696 Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635 G S + E + T AAP P ++ + +V P + W+ P++ Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748 Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672 Y ++ R QG++G W+ V DP + + T VP IK Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787 Score = 90.1 bits (222), Expect = 1e-17 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%) Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214 L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + + Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505 Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273 T L V I P+++ V+ C A P+ + +W D ++ + Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565 Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333 + DG L + + D G Y+CV S L + A L V+ PG + V ++ Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622 Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371 LL VSW+ + K + +K+ G G + S + L + Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681 Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426 + T N G PSPV+ ++ A + P + + G E ++I Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739 Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481 + P V V W G Q Q+ S+ L++ + + A N+ + Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799 Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532 T Y P + + + + + V W P G+L+ ++V W + Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859 Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592 + + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919 Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646 P A L ++ +LL W PP L GYVL EG + Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963 Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682 G + + DP + L P L Y F+L A Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995 Score = 69.3 bits (168), Expect = 2e-11 Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%) Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185 V PP E P L V + ++L+C A G P W G ++LG Q Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89 Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237 +G+ I + G+Y C AS+ G+A +H +L+ G P PK + Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146 Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292 V + V L C+ L W N + HI + RV + +G+L L + Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203 Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327 D C+ P LL P ++S++L L P V+ Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263 Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387 C + P + W + + D+ + + ++ +G ED GEY C NSLG+ Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320 Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447 A V ++A P ++ +P+ + G + C QG P P V+W G ++ A Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377 Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496 + +LIL + +C A N + + +YV+ ++T Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430 >gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo sapiens] Length = 1257 Score = 117 bits (294), Expect = 5e-26 Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%) Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72 ++++GA K V V GESVVL C+ PP PL + W+ L Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177 Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126 I D RV + + +L + D Y C F + Q P D + Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232 Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186 + F + L + +P+ L C+A G P P + W + + Q Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292 Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246 N TL++ +V G Y C A ++ GSA HA + V P + P++ + L Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352 Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305 C + P +W + I V +++ Q + RI G+L L QP D C N Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409 Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345 GLL A+AY+ V+ +P I P+ V W +DG Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466 Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405 LQ ++F ++ GT G I L D G Y C N + + + +K Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459 + P+ ++ G + C A DP P ++W GR LQ D + L++ Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580 Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516 L G++ C AS + V + + V+G+ P +V + + VSW P D Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640 Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575 ++++ + + P++ W SL G L P+ Y F V A NK G Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696 Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635 G S + E + T AAP P ++ + +V P + W+ P++ Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748 Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672 Y ++ R QG++G W+ V DP + + T VP IK Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787 Score = 90.1 bits (222), Expect = 1e-17 Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%) Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214 L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + + Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505 Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273 T L V I P+++ V+ C A P+ + +W D ++ + Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565 Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333 + DG L + + D G Y+CV S L + A L V+ PG + V ++ Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622 Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371 LL VSW+ + K + +K+ G G + S + L + Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681 Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426 + T N G PSPV+ ++ A + P + + G E ++I Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739 Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481 + P V V W G Q Q+ S+ L++ + + A N+ + Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799 Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532 T Y P + + + + + V W P G+L+ ++V W + Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859 Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592 + + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919 Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646 P A L ++ +LL W PP L GYVL EG + Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963 Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682 G + + DP + L P L Y F+L A Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995 Score = 69.3 bits (168), Expect = 2e-11 Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%) Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185 V PP E P L V + ++L+C A G P W G ++LG Q Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89 Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237 +G+ I + G+Y C AS+ G+A +H +L+ G P PK + Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146 Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292 V + V L C+ L W N + HI + RV + +G+L L + Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203 Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327 D C+ P LL P ++S++L L P V+ Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263 Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387 C + P + W + + D+ + + ++ +G ED GEY C NSLG+ Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320 Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447 A V ++A P ++ +P+ + G + C QG P P V+W G ++ A Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377 Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496 + +LIL + +C A N + + +YV+ ++T Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 117 bits (294), Expect = 5e-26 Identities = 94/365 (25%), Positives = 150/365 (41%), Gaps = 35/365 (9%) Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ--VQNGTLRIRRVERGS 200 P +V V C A G+P P + W +L + +GTL I+ + Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311 Query: 201 SGVYTCQASSTEGSA-THATQLLVLGPPV---IVVPPKNSTVNASQDVSLACHAEAYPAN 256 G+Y C A + G T L G P V+ P+N+ V + V+L C A +P Sbjct: 312 QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371 Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316 SW + + + PRV I G L + D+G Y C +N + A+A+ Sbjct: 372 -RISWTRGDRTPLPVD---PRVNITPSGGLYIQNVVQGDSGEYACSATNNI-DSVHATAF 426 Query: 317 LTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQLDK-FPGWSQG 359 + V +P +C + NPP + ++WTK G L +D+ S G Sbjct: 427 IIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWTKGGSQLSVDRRHLVLSSG 485 Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 T +AL ++ G+Y C N +G+ V + P F P + EVG Sbjct: 486 TLRISGVALHDQ---GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGAN 541 Query: 420 LLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVA 477 + +PCS+QG+P P ++W K G + G+ + L + + G +EC A N + Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601 Query: 478 RVATS 482 + S Sbjct: 602 SASVS 606 Score = 84.3 bits (207), Expect = 6e-16 Identities = 82/279 (29%), Positives = 112/279 (40%), Gaps = 43/279 (15%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 GESV L C G PP I W R G P+ +DP RV + L Sbjct: 356 GESVTLECSA---TGHPPPR-ISWTR-GDRTPL---------PVDP----RVNITPSGGL 397 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 I+ + D G Y C + F + V + PQF TP + + E + Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAF-------IIVQALPQFTVTPQDRVVI-EGQT 449 Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213 V +C A+G+P P + W G L + + + +GTLRI V G Y CQA + G Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509 Query: 214 SATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--- 268 S L V PV P ++TV +V L C ++ P +W +D + V Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEP-EPAITWNKDGVQVTES 568 Query: 269 --FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN 305 FHIS +G L + P DAG Y CV N Sbjct: 569 GKFHIS---------PEGFLTINDVGPADAGRYECVARN 598 Score = 79.7 bits (195), Expect = 1e-14 Identities = 87/332 (26%), Positives = 135/332 (40%), Gaps = 32/332 (9%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 R+ L +L I+ + DQG Y+C + + + + + + P F P Sbjct: 293 RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEV---TLRYFGSPARPTF-VIQP 348 Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSG 202 EV E VTL C A G P P ++W + +V + +G L I+ V +G SG Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSG 408 Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262 Y C A++ S ++V P V P++ V Q V C A+ P + +W Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWT 467 Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV--- 319 + + + R +L G+LR+ D G Y C N ++ A+LTV Sbjct: 468 KGGSQL----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVN-IIGSQKVVAHLTVQPR 522 Query: 320 -----LCMPGVIRCPVRAN---------PPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365 +P V AN P ++W KDG +Q+ + + EG L Sbjct: 523 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPEGFLT 580 Query: 366 I-ALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396 I +G DA G Y C N++G+A S V V Sbjct: 581 INDVGPADA-GRYECVARNTIGSASVSMVLSV 611 Score = 61.6 bits (148), Expect = 4e-09 Identities = 63/282 (22%), Positives = 107/282 (37%), Gaps = 15/282 (5%) Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387 C NP + W ++ L + + +G+L+I E G Y C N G Sbjct: 267 CRAEGNPKPEII-WLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGE 325 Query: 388 AGPSPVTRVLLKAP--PAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--- 442 VT +P P F+ +P+ VG + + CSA G PPP +SWT+ R Sbjct: 326 VKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESVTLECSATGHPPPRISWTRGDRTPLP 384 Query: 443 LQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVA 502 + + + + L ++ + + G + CSA+N + V + + V VT V Sbjct: 385 VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVV 444 Query: 503 LPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562 + +G V ++ G + DR H + + + L + G+ H Sbjct: 445 I-EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH-------LVLSSGTLRISGVALHD 496 Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEI 604 Q Q+ A N +GS + P P + P E+ Sbjct: 497 QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV 538 Score = 48.5 bits (114), Expect = 4e-05 Identities = 56/200 (28%), Positives = 82/200 (41%), Gaps = 35/200 (17%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G++V C+ G PP VI W + G L + + + S +L Sbjct: 447 GQTVDFQCEA---KGNPP-PVIAWTKGGSQLSVDRRHLVLS---------------SGTL 487 Query: 94 QIEGLRVEDQGWYECRVFFL--DQHIPEDDFANGSWVHLTVNS--PPQFQETPPAVLEVQ 149 +I G+ + DQG YEC+ + Q + HLTV P F P V+ Sbjct: 488 RISGVALHDQGQYECQAVNIIGSQKVV---------AHLTVQPRVTPVFASIPSDTT-VE 537 Query: 150 ELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSSGVYTCQA 208 V L C ++G P P +TW G + + G+ + G L I V +G Y C A Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVGPADAGRYECVA 596 Query: 209 SSTEGSATHATQLLVLGPPV 228 +T GSA+ + L V P V Sbjct: 597 RNTIGSASVSMVLSVNVPDV 616 >gi|27894376 cell adhesion molecule with homology to L1CAM precursor [Homo sapiens] Length = 1224 Score = 115 bits (289), Expect = 2e-25 Identities = 153/651 (23%), Positives = 245/651 (37%), Gaps = 101/651 (15%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G+ +VL C+ PP G PPLH+ W+ I+ D RV + + L Sbjct: 146 GDPIVLPCN--PPKGLPPLHIY-WMNIEL------------EHIEQDE--RVYMSQKGDL 188 Query: 94 QIEGLRVEDQGWYEC------RVFFLDQHIP----------EDDFANGSWVHLTVNSPPQ 137 + +D C R+ + Q +P +D ++ + + NS Q Sbjct: 189 YFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQ 248 Query: 138 FQET---PP------AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN 188 + PP + + + + E + L C A G P P V W G DL +G+ + Sbjct: 249 RKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYG 308 Query: 189 GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248 TL+I V G Y C AS+ G+ATH ++V PP P+++ + + L C Sbjct: 309 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 368 Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--- 305 AE P T W +N + ++ + QP+ Y C SN Sbjct: 369 EAEGEP-QPTIKW---RVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHG 424 Query: 306 --------------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTK--DGKALQ 349 L+ Y TV+ + C A+P + VSW K + K L+ Sbjct: 425 TILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAV-VSWQKVEEVKPLE 483 Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG----TAGPSPVTRVLLKAPPAFI 405 ++ + GT L I E+ G YSC N++G TA L+ P Sbjct: 484 GRRYHIYENGT---LQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSP--- 537 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-----SNSSLILRPL 460 + P+ + C + +SW+K G + D ++L + + Sbjct: 538 KNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNV 597 Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-KGANVSWEPGFD-GG 518 T E G + CSA A+ A T V VL P N+ + + ++WE G D Sbjct: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV-PDPPENLHLSERQNRSVRLTWEAGADHNS 656 Query: 519 YLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGP 578 + + V + + P R W L G ++ L P +YQF V+A N++G Sbjct: 657 NISEYIVEFEGNKEEPGR----WEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQ 712 Query: 579 FSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629 S+ + T PAAP P I V P+ +++ W+P Sbjct: 713 PSQ----PSDHHETPPAAPDRNPQNI---------RVQASQPKEMIIKWEP 750 Score = 79.3 bits (194), Expect = 2e-14 Identities = 175/755 (23%), Positives = 279/755 (36%), Gaps = 140/755 (18%) Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG-------RVRLQKGASLQI 95 LLPP I L+ LL GL +P++D + +G + G +L+I Sbjct: 254 LLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKI 313 Query: 96 EGLRVEDQGWYECRVF-FLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPV 154 E + +D+G Y C FL DF H+ V PP++ + P + + + Sbjct: 314 ENVSYQDKGNYRCTASNFLGT--ATHDF------HVIVEEPPRWTKKPQSAVYSTGSNGI 365 Query: 155 TLRCVARGSPLPHVTWKLRGKDLGQGQ--GQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212 L C A G P P + W++ G + G V V + ++ + VY C+AS+ Sbjct: 366 LL-CEAEGEPQPTIKWRVNGSPVDNHPFAGDV-VFPREISFTNLQPNHTAVYQCEASNVH 423 Query: 213 GS--ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFH 270 G+ A ++ + P + +N L C A P + SW + Sbjct: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVV-SWQK------- 475 Query: 271 ISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGL--------LHPPSASAYLT 318 + ++P R I +G+L++ T +DAG Y+C N + L +A+ Sbjct: 476 VEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRV 535 Query: 319 VLCMPGV-------IRCPVRANPPL---LFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368 P + + C + + L L +SW+KDG+A +++ GTE II Sbjct: 536 SPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEIN-------GTEDGRIIID 588 Query: 369 GNEDAL--------GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE-VGRE 419 G + G Y C+ + +L +A + +T+V + P + P+ + E R Sbjct: 589 GANLTISNVTLEDQGIYCCSAHTALDSA--ADITQVTVLDVP---DPPENLHLSERQNRS 643 Query: 420 LLIPCSAQGDPPPVVSWTKV---------GRGLQGQAQVDSNSSLILRPLTKEAHGHWEC 470 + + A D +S V GR + +V + ++ PL + Sbjct: 644 VRLTWEAGADHNSNISEYIVEFEGNKEEPGRW-EELTRVQGKKTTVILPLAPFVRYQFRV 702 Query: 471 SASNAVARVATSTNVYVLGTSPHVVT----NVSVVAL-PKGANVSWEP----GFDGGYLQ 521 A N V R S T P N+ V A PK + WEP +G L+ Sbjct: 703 IAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLE 762 Query: 522 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSE 581 W +P +W V ++ P + + Y V A N+LGSGP Sbjct: 763 YRVTW------KPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSGP--- 811 Query: 582 IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD--PPELVPKRLDG 639 P + L E P +P V V V + W P + V RL G Sbjct: 812 -----------DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKG 860 Query: 640 Y---------VLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690 Y +L+GR + +L +G +VP L D EF L A Sbjct: 861 YQINWWKTKSLLDGRTHPKEVNIL--RFSGQRNSGMVPSL--DAFSEFHLTVLA------ 910 Query: 691 PSNTANVSTSGLEVYPSRTQLP-GLLPQPVLAGVV 724 N +G E P Q P G+ QP V+ Sbjct: 911 ----YNSKGAGPESEPYIFQTPEGVPEQPTFLKVI 941 Score = 57.0 bits (136), Expect = 1e-07 Identities = 95/417 (22%), Positives = 147/417 (35%), Gaps = 73/417 (17%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTW-KLRGKDLGQGQGQVQ 185 + V S P+F + LEV+E +P+ L C +G P H+ W + + + Q + Sbjct: 123 IEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYM 182 Query: 186 VQNGTLRIRRV-ERGSSGVYTCQAS--------------STEGSATHA------------ 218 Q G L V E+ S Y C A+ T S HA Sbjct: 183 SQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSK 242 Query: 219 TQLLVLGPPVIVVPPKNS------TVNASQDVSLACHAEAYPANLTYSWFQDNINVFHIS 272 + P +++PP S T+ + + L C AE P ++ I Sbjct: 243 ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPT--------PQVDWNKIG 294 Query: 273 RLQPRVRILVDG---SLRLLATQPDDAGCYTCVPSNGL-----------------LHPPS 312 P+ R + +L++ D G Y C SN L P Sbjct: 295 GDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQ 354 Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-WSQGTEGSLIIALGNE 371 ++ Y T G++ C P + W +G + F G E S N Sbjct: 355 SAVYST--GSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNH 411 Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPP 431 A+ Y C N GT + V + P + E Y VG + C P Sbjct: 412 TAV--YQCEASNVHGTILANANIDV-VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 468 Query: 432 PVVSWTKVG--RGLQGQA-QVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485 VVSW KV + L+G+ + N +L + T+E G + C NA+ + A + N+ Sbjct: 469 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525 Score = 40.8 bits (94), Expect = 0.008 Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 17/112 (15%) Query: 390 PSPVTRV--LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--LQG 445 PS V +V ++K + P +EYFQ I C A+G+P P SWTK G Sbjct: 28 PSSVQQVPTIIKQSKVQVAFPFDEYFQ-------IECEAKGNPEPTFSWTKDGNPFYFTD 80 Query: 446 QAQVDSNSSLILRPLTKEAH-----GHWECSASNAVARVATSTNVYVLGTSP 492 + SN+S R + E H G + C ASN + + +++ + P Sbjct: 81 HRIIPSNNSGTFR-IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVP 131 >gi|83281200 protogenin [Homo sapiens] Length = 1150 Score = 115 bits (288), Expect = 2e-25 Identities = 139/582 (23%), Positives = 233/582 (40%), Gaps = 75/582 (12%) Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI-----RRVE 197 P + V +PV L C A G VTW G + + + + NG+L I RR E Sbjct: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104 Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGP-PVIVVPPKNSTVNASQDVSLACHAEAYPAN 256 + G Y C A + G+ L L V P ++ V+ AC ++P Sbjct: 105 QSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPP- 163 Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316 +W N + R+ L G L++ D+G Y C+ + S A Sbjct: 164 AVITW---EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEAS 220 Query: 317 LTV------------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLD 351 LTV L V+ C NP + +SW++ D K+ +D Sbjct: 221 LTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPI-ISWSRLDHKS--ID 277 Query: 352 KFPGWSQGTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFIERP 408 F G G+L+I+ G Y C TP T + +T + APP+F+E P Sbjct: 278 VFNTRVLG-NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT---VLAPPSFVEWP 333 Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDS-NSSLILRPLTKEAHGH 467 + G + C A+G P P +SW K GR + ++ NS L++ + E Sbjct: 334 ESLTRPRAGTARFV-CQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392 Query: 468 WECSASNAVARVATSTNVYVLGTS--PHVVTNVSVVALPKGA-NVSWE-PGFDGGYLQRF 523 ++C A N+ + + + V+ + P NV + A ++WE P ++ + + Sbjct: 393 YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAY 452 Query: 524 SVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583 SV Y + + ++++ + + H ++ L+P + Y F ++A +G+ S+ V Sbjct: 453 SVHY----MKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508 Query: 584 LSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKR--LDGYV 641 T PL PP + R+P +L+ W P +R + Y Sbjct: 509 TQ---------------NTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553 Query: 642 LEGRQGSQ-GWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682 L R ++ +VL+ + GT E L+ GL D +Y R+ A Sbjct: 554 LSFRLSTENSIQVLE--LPGTTHEYLLEGLKPDSVYLVRITA 593 Score = 45.1 bits (105), Expect = 4e-04 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 7/122 (5%) Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616 GL P +Y +LA N + G ++ +S TP + +PPP P Sbjct: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVS-------TPGCVSVRDRMVPPPPPPHHLYAK 731 Query: 617 VRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLY 676 T + LHW P ++ Y + L + +ET +LV GL + Y Sbjct: 732 ANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKY 791 Query: 677 EF 678 EF Sbjct: 792 EF 793 Score = 42.7 bits (99), Expect = 0.002 Identities = 59/263 (22%), Positives = 101/263 (38%), Gaps = 36/263 (13%) Query: 513 PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 572 P F + +++ P+ + + + L + H+LV GL+P+T+Y+F+V Sbjct: 745 PAFTAAQIINYTIRCNPVG-----LQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHV 799 Query: 573 KLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPL-SPPRGLVAVRTPRGVLLHWDPPE 631 S P+S +V + T P AP PP + L LV+ + P D PE Sbjct: 800 DQLSSPWSPVVYHS-----TLPEAPAGPPVGVKVTLIEDDTALVSWKPP-------DGPE 847 Query: 632 LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690 V R + G W+VL G T L+ L+ +Y ++ A Sbjct: 848 TVVTRYTILYASRKAWIAGEWQVLHR--EGAITMALLENLVAGNVYIVKISASNEVGEGP 905 Query: 691 PSNTANVSTSGLEVYPSRTQLPGL-------------LPQPVLAGVVGGVCFLGVAVLVS 737 SN+ ++ E S + L L Q + G+ GV +L+ Sbjct: 906 FSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILIC 965 Query: 738 ILAGCLLNRRRAARRRRKRLRQD 760 +L L+ R +A + + Q+ Sbjct: 966 VL--ILIYRSKARKSSASKTAQN 986 >gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42 precursor [Homo sapiens] Length = 2012 Score = 115 bits (288), Expect = 2e-25 Identities = 122/471 (25%), Positives = 201/471 (42%), Gaps = 92/471 (19%) Query: 87 LQKGASLQIEGLRVE----------DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136 L G +++I G+ E D G Y+C F + D+ V L +P Sbjct: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAYQC--FVRKDKLSAQDYVQ---VVLEDGTPK 408 Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQNGT-- 190 V V EPV+L C +G+PLP +TW L + +G Q+ G Sbjct: 409 IISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466 Query: 191 --LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248 L I + GVY C A+++ G + ++ V G P + P KN T A +D + C Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHC 525 Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGL 307 YP + W++ N N+ + Q V +G+L+L Q + D G YTC N L Sbjct: 526 RVIGYP-YYSIKWYK-NSNLLPFNHRQ--VAFENNGTLKLSDVQKEVDEGEYTC---NVL 578 Query: 308 LHP---PSASAYLTVLCMPGV---------------IRCPVRANPPLLFVSWTKDGKALQ 349 + P S S ++TV P + I C V + + ++W KDG+ + Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI- 637 Query: 350 LDKFPGWSQGTEGSLIIALGNEDAL-------------GEYSCTPYNSLGTAGPSPVTRV 396 GSL + + N D G Y+C N A +++ Sbjct: 638 -----------PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE--AAAVEHQSQL 684 Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG----------LQGQ 446 +++ PP F+ +P+++ G+ +++ CSA+G P P + W K +G L G+ Sbjct: 685 IVRVPPKFVVQPRDQ-DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGR 742 Query: 447 AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN 497 QV SN SL+++ + +E G++ C SN V S ++Y+ P ++T+ Sbjct: 743 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITS 792 Score = 95.1 bits (235), Expect = 3e-19 Identities = 155/699 (22%), Positives = 272/699 (38%), Gaps = 127/699 (18%) Query: 51 PLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVE-DQGWYECR 109 P + I+W + LLP ++ R +V + +L++ ++ E D+G Y C Sbjct: 531 PYYSIKWYKNSNLLP-------FNHR-------QVAFENNGTLKLSDVQKEVDEGEYTCN 576 Query: 110 VFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLP-HV 168 V Q + VH+TV PP Q P + V + CV LP + Sbjct: 577 VLVQPQ------LSTSQSVHVTVKVPPFIQ--PFEFPRFSIGQRVFIPCVVVSGDLPITI 628 Query: 169 TWKLRGKDLGQGQGQVQVQN----GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL 224 TW+ G+ + G V + N +LRI + +G YTC A + + H +QL+V Sbjct: 629 TWQKDGRPIPGSLG-VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687 Query: 225 GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--FHISRLQPRVRILV 282 PP VV P++ + V L C AE YP F V F L R+++L Sbjct: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747 Query: 283 DGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVI---------------- 326 +GSL + +D+G Y C SN + S S YLTV +P +I Sbjct: 748 NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK-IPAMITSYPNTTLATQGQKKE 806 Query: 327 -RCPVRANPPLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALG-----NEDALGEYS 378 C P++ V W K+ + + ++ ++ ++ +I L ED+ G +S Sbjct: 807 MSCTAHGEKPII-VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDS-GFFS 864 Query: 379 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELL----------------- 421 C NS G + ++ ++ PP P E ++V + Sbjct: 865 CHAINSYGE--DRGIIQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGY 918 Query: 422 -IPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480 I C + D SW R Q++S + + + P + + + A N + + Sbjct: 919 DIECKNKSD-----SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY---AKNRIGKSE 970 Query: 481 TSTNVYVLG-----TSPHVVTNVSVVALPKGANVSW---EPGFDGGYLQRFSVWYTPLAK 532 S + + P ++ ++ + V+W + G ++ + + Y + Sbjct: 971 PSNELTITADEAAPDGPPQEVHLEPIS-SQSIRVTWKAPKKHLQNGIIRGYQIGYREYS- 1028 Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLP 591 + +S+ + + L TQY V A N+ G+GP S EI+ + E +P Sbjct: 1029 TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP 1088 Query: 592 TTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQGSQG 650 + PP + A+ T P + + W L + L+G +L+G + Sbjct: 1089 S----------------YPPENVQAIATSPESISISWS--TLSKEALNG-ILQGFRVIYW 1129 Query: 651 WEVLD------PAVAGTETELLVPGLIKDVLYEFRLVAF 683 ++D + T+ L + GL K Y +++AF Sbjct: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168 Score = 69.3 bits (168), Expect = 2e-11 Identities = 47/179 (26%), Positives = 79/179 (44%), Gaps = 26/179 (14%) Query: 418 RELLIPCSAQGDPPPVVSWTKVGRG------LQGQAQVDSNSSLILRPLTKEAHGHWECS 471 +++++PC A GDP P V W K G + G+ + SN S I+R + E G++ C Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360 Query: 472 ASN--AVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG-----GYLQRFS 524 A+N + + V V P + + + +SW PG +G GY+ ++S Sbjct: 1361 ANNNWGSDEIILNLQVQVPPDQPRLTVSKTT---SSSITLSWLPGDNGGSSIRGYILQYS 1417 Query: 525 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583 + W S + + L+ T Y+F++ AQN +G G SEI+ Sbjct: 1418 ----------EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEII 1466 Score = 65.1 bits (157), Expect = 4e-10 Identities = 103/443 (23%), Positives = 167/443 (37%), Gaps = 62/443 (13%) Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143 R + +L I+ ++ ED G Y R ++ E +N + L V+ P + P Sbjct: 172 RFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSA--RLFVSDPAN---SAP 225 Query: 144 AVLE------VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197 ++L+ + V L C A G P P W L + G+ Q L I + Sbjct: 226 SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIR 284 Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANL 257 SG Y C+ S+ G+A +L V P + P+ + VSL+C + Sbjct: 285 PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG-TEDQ 343 Query: 258 TYSWFQDNINVFHISRLQPRVRILVDG----SLRLLATQPDDAGCYTCVPSNGLLHPPSA 313 SW+++ L P + + G +L + D G Y C L SA Sbjct: 344 ELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL---SA 394 Query: 314 SAYLTVLCMPGV-------------------IRCPVRANPPLLFVSWTKDGKALQLDKFP 354 Y+ V+ G + C V+ PL ++WT D + Sbjct: 395 QDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGT-PLPTITWTLDDDPILKGGSH 453 Query: 355 GWSQ--GTEGSLIIALGNEDAL----GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408 SQ +EG+++ L + G Y CT NS G R+ ++ P + RP Sbjct: 454 RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVV--LYQARINVRGPASI--RP 509 Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEA- 464 + GR+ I C G P + W K L Q ++N +L L + KE Sbjct: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569 Query: 465 HGHWECSASNAVARVATSTNVYV 487 G + C+ +++TS +V+V Sbjct: 570 EGEYTCNVL-VQPQLSTSQSVHV 591 Score = 45.4 bits (106), Expect = 3e-04 Identities = 53/207 (25%), Positives = 80/207 (38%), Gaps = 31/207 (14%) Query: 31 GRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYV-GRVRLQK 89 G G++V+L C A P+ I W G P+ P + GR+++ Sbjct: 701 GIYGKAVILNCS----AEGYPVPTIVWK---------FSKGAGVPQFQPIALNGRIQVLS 747 Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETPPAVLEV 148 SL I+ + ED G+Y C+V D A+ S ++LTV P P L Sbjct: 748 NGSLLIKHVVEEDSGYYLCKV-------SNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 800 Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN--------GTLRIRRVERGS 200 Q + + C A G V W+ + + + V TL+I R Sbjct: 801 QG-QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859 Query: 201 SGVYTCQASSTEGSATHATQLLVLGPP 227 SG ++C A ++ G QL V PP Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQEPP 886 Score = 36.6 bits (83), Expect = 0.14 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 10/84 (11%) Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-------NGTLRIRRVERGSSGV 203 ++ + L C A G P P V W KD V + NG+ IR V+ SG Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWM---KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356 Query: 204 YTCQASSTEGSATHATQLLVLGPP 227 Y+C A++ GS L V PP Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPP 1380 Score = 32.0 bits (71), Expect = 3.5 Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 1/64 (1%) Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301 +D+ L C A P+ W +D+ + + R I +GS + + +D+G Y+C Sbjct: 1301 KDIVLPCKAVGDPSPAV-KWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359 Query: 302 VPSN 305 + +N Sbjct: 1360 IANN 1363 >gi|134244585 putative neuronal cell adhesion molecule [Homo sapiens] Length = 814 Score = 113 bits (282), Expect = 1e-24 Identities = 139/570 (24%), Positives = 225/570 (39%), Gaps = 67/570 (11%) Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR--RVERGSS----GVYT 205 +P+ L C G+P +TW+ G +L + + NG+L IR R+E G S G Y Sbjct: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116 Query: 206 CQASSTEG-SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264 C A + G + ++ V P+ + C P L +W ++ Sbjct: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL-ITWEKN 175 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV----- 319 + I R +L G L++ + +D G + CV SN S A LTV Sbjct: 176 RV---PIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGS 232 Query: 320 ------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQGT 360 + V+ C NP + VSW++ DG+ + ++ G Sbjct: 233 GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRLDGRPIGVE---GIQVLG 288 Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420 G+LII+ G Y C + R++++AP F++ P + + G Sbjct: 289 TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP-QSISRPAGTTA 347 Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVA 477 + C AQG+PPP V+W K G+ L V ++NS+L + + E ++C A N+ Sbjct: 348 MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAG 407 Query: 478 RVATSTNVYVLGTS--PHVVTNVSVVALPK-GANVSW-EPGFDGGYLQRFSVWYTPLAKR 533 S + VL P NV V++ VSW EP + + + + A Sbjct: 408 SSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADP 467 Query: 534 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 593 P+ + + AV LV L+P T Y F + A G+ S +PT Sbjct: 468 PELEYQE----AVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS---------VPTL 514 Query: 594 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV 653 + G P PPPLS V V + L W+P + + G+ L R S+ Sbjct: 515 ASTLGEAPA--PPPLS-----VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567 Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF 683 + GT + + L +YE +L+A+ Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAY 597 Score = 69.7 bits (169), Expect = 2e-11 Identities = 84/282 (29%), Positives = 120/282 (42%), Gaps = 29/282 (10%) Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136 ID D L KG LQI GLR ED G + C + +I ++G+ LTV+ Sbjct: 179 IDTDNERYTLLPKGV-LQITGLRAEDGGIFHC----VASNIASIRISHGA--RLTVSGSG 231 Query: 137 QFQETPPAVLEVQELEPVT------LRCVARGSPLPHVTW-KLRGKDLGQGQGQVQVQNG 189 PA+L E +T L CVA G+P P V+W +L G+ +G +G + G Sbjct: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGV-EGIQVLGTG 290 Query: 190 TLRIRRVERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247 L I V SGVY C A+ T T +L+V P V P++ + A Sbjct: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350 Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNG 306 C A+ P +W ++ + VR+ + S L + P+D Y CV N Sbjct: 351 CQAQGEPPP-HVTWLKNG----QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405 Query: 307 LLHPPSASAYLTVLCMPGVIRCP-----VRANPPLLFVSWTK 343 ASA LTVL G+ P V + + VSW++ Sbjct: 406 -AGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSE 446 Score = 33.9 bits (76), Expect = 0.93 Identities = 26/100 (26%), Positives = 44/100 (44%), Gaps = 9/100 (9%) Query: 390 PSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQA 447 P+P + A AF P ++ G+ +++ C +G PP ++W K G L + Sbjct: 30 PAPSEGLGHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS 88 Query: 448 QVDSNSSLILRPLTKEA------HGHWECSASNAVARVAT 481 + +N SL++R E G +EC A N V + Sbjct: 89 TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVS 128 >gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo sapiens] Length = 1250 Score = 111 bits (277), Expect = 5e-24 Identities = 142/582 (24%), Positives = 225/582 (38%), Gaps = 79/582 (13%) Query: 160 ARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR--VERGSS-----------GVYTC 206 A P VTW G L + + NG+L + + GS G Y+C Sbjct: 62 AAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSC 121 Query: 207 QASSTEGSATHATQLLVLGPPV-IVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265 A G T ++ L + P++ TV + CH E PA + +W +D Sbjct: 122 LAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPII-TWEKDQ 180 Query: 266 INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYL-------- 317 + + +PR+ +L +G L++L Q DAG Y CV +N S A L Sbjct: 181 VTLPE----EPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSL 236 Query: 318 -----------------TVLCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQG 359 TV+ V+ V + P FVSW + DGK + D Sbjct: 237 ASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRT- 295 Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 +L+IA G Y C + + + A PA + P E + Sbjct: 296 ---NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAP-EALSRTRAST 351 Query: 420 LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNA- 475 C A G+P P + W G L+ +V SL++ + + G+++C A N+ Sbjct: 352 ARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSA 411 Query: 476 -VARVATSTNVYVLGTSPHVVTNVSVVALPKGAN-VSWE-PGFDGGYLQRFSVWYTPLAK 532 +A A S V V P T V+ L A V+WE P + FS+ Y A+ Sbjct: 412 GMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQK-AR 470 Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592 D + + + AV L V L+P+T Y+F V+A ++LG+ S Sbjct: 471 GMDNVEYQF---AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTS------------ 515 Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP--PELVPKRLDGYVLEGRQGSQG 650 P L T P + P+ ++ P + + W P P L ++ Y +E G + Sbjct: 516 ---TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED 572 Query: 651 WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPS 692 ++ V G ET+L++ L + +Y R+ A + PS Sbjct: 573 -QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS 613 Score = 83.6 bits (205), Expect = 1e-15 Identities = 145/606 (23%), Positives = 229/606 (37%), Gaps = 99/606 (16%) Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202 P V+E C G P P +TW+ L + + + NG L+I V+ +G Sbjct: 149 PESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAG 208 Query: 203 VYTCQASSTEGSATHATQLLVLG-------------PPVIVVPPKNSTVNASQDVSLACH 249 Y C A T + H +Q +L VIV P+N+TV + Q V + C Sbjct: 209 PYRCVA--TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266 Query: 250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLH 309 A A P SW + + + V +L +L + QP +G Y C + Sbjct: 267 ASADPTPFV-SWVRQD-----GKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320 Query: 310 P-PSASAYLTVLCMPGVIRCP-----VRAN----------PPLLFVSWTKDGKALQLDKF 353 +A+A L VL P + + P RA+ P + W +G L+ + Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380 Query: 354 PGWSQGTEGSLIIA-LGNEDALGEYSCTPYNSLGTA----------------GPSPVTRV 396 QG GSL+I +G +DA G Y C NS G A P+ VT Sbjct: 381 VK-VQGGGGSLVITQIGLQDA-GYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTAT 438 Query: 397 LLKAPPAFI--ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454 L + + ERP+ Q +G L + D ++ Q V+++++ Sbjct: 439 PLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMD------------NVEYQFAVNNDTT 486 Query: 455 -LILRPLTKEAHGHWECSASN--AVARVATSTNVYVLGTSPHVVTNVSVVA-LPKGANVS 510 L +R L + A + +R +T V+ L P +S+ + P V+ Sbjct: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546 Query: 511 W---EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFS 567 W P G + ++ + Y + D++ S V L++ LQP+ Y+ Sbjct: 547 WLPLPPSLSNGQVVKYKIEYG--LGKEDQI----FSTEVRGNETQLMLNSLQPNKVYRVR 600 Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP------R 621 + A G G S+ + + P P E+ +V+ + P Sbjct: 601 ISAGTAAGFGAPSQWMHHRTPSMHNQSHVP-FAPAELKVQAKMESLVVSWQPPPHPTQIS 659 Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV----LDPAVAGTETELLVPGLIKDVLYE 677 G L+W + +G L G +G Q W+V L V E LVPG LYE Sbjct: 660 GYKLYWREVG-AEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR----LYE 714 Query: 678 FRLVAF 683 +LVAF Sbjct: 715 VKLVAF 720 Score = 61.6 bits (148), Expect = 4e-09 Identities = 101/401 (25%), Positives = 144/401 (35%), Gaps = 85/401 (21%) Query: 553 LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612 +L+ GL+P T+Y+F+V + GPF +V + T P P PP+++ LSP Sbjct: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS-----TLPDRPSTPPSDL--RLSP-- 858 Query: 613 GLVAVRTPRGVLLHWDPP-----ELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLV 667 TP V LHW PP E+V + L Y Q W +L G V Sbjct: 859 -----LTPSTVRLHWCPPTEPNGEIV-EYLILYSSNHTQPEHQWTLL--TTQGNIFSAEV 910 Query: 668 PGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727 GL D Y F++ A S +V T + +L L + G++ GV Sbjct: 911 HGLESDTRYFFKMGARTEVGPGPFSRLQDVIT-------LQEKLSDSLDMHSVTGIIVGV 963 Query: 728 CFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPT-GKSAAPSALGSGSPDSVA 786 C LG+ CLL A RR P L + T G A S G P A Sbjct: 964 C-LGLL--------CLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPA 1014 Query: 787 KLKLQG---------SPVPS----------------------LRQSLLWGDPAG------ 809 +L+ SP PS ++ + W P+G Sbjct: 1015 AHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGS 1074 Query: 810 -----TPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRL 864 P P P +R LP G ++ V + +GR+++ P Q Sbjct: 1075 WAGCELPQAGPRPALTRALLP----PAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVE 1130 Query: 865 ARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPG 905 A S S S L ++D+ P P P P + G G Sbjct: 1131 AEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVG 1171 Score = 47.0 bits (110), Expect = 1e-04 Identities = 123/547 (22%), Positives = 200/547 (36%), Gaps = 98/547 (17%) Query: 224 LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD 283 +GP +++ P+ + V + SL A P +T W +D + L +L + Sbjct: 40 VGPLQVILGPEQAAV---LNCSLGAAAAGPPTRVT--WSKDGDTLLEHDHLH----LLPN 90 Query: 284 GSLRL---LATQPDDA----------GCYTCVPSN--GLLHPPSASAYLTVLC------- 321 GSL L LA D G Y+C+ G+L +A L L Sbjct: 91 GSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPE 150 Query: 322 -----MPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDAL 374 G R C + P + ++W KD + L + P G L I E Sbjct: 151 SQTVEENGTARFECHIEGLPAPI-ITWEKD--QVTLPEEPRLIVLPNGVLQILDVQESDA 207 Query: 375 GEYSCTPYNSL---------------GTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419 G Y C NS G+ + V++ A P E G+ Sbjct: 208 GPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAP-------ENTTVVSGQS 260 Query: 420 LLIPCSAQGDPPPVVSWTKV-GRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478 +++ C A DP P VSW + G+ + V ++L++ G + C A+ R Sbjct: 261 VVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320 Query: 479 -VATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRM 537 AT+ + +P + ++ + + + G + RP+ Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380 Query: 538 HHDWVSLAVPVGAAHLLVP--GLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEGLPTTP 594 + V G L++ GLQ YQ +A+N G + + + EGLP+ P Sbjct: 381 ------VKVQGGGGSLVITQIGLQDAGYYQ--CVAENSAGMACAAASLAVVVREGLPSAP 432 Query: 595 AAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVL 654 P + VL+ W+ PE+ +++ G+ L Q ++G + + Sbjct: 433 TRVTATPL----------------SSSAVLVAWERPEMHSEQIIGFSLH-YQKARGMDNV 475 Query: 655 DP--AVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRT-QL 711 + AV TEL V L + YEF +VA++ S S A V T L+ PS QL Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHT--LDDVPSAAPQL 533 Query: 712 PGLLPQP 718 P P Sbjct: 534 SLSSPNP 540 Score = 35.0 bits (79), Expect = 0.42 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%) Query: 504 PKGANVSWEPGFD-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562 P + W P + G + + + Y+ +P+ H W L V GL+ T Sbjct: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPE---HQWTLLTTQGNIFSAEVHGLESDT 917 Query: 563 QYQFSVLAQNKLGSGPFSEI 582 +Y F + A+ ++G GPFS + Sbjct: 918 RYFFKMGARTEVGPGPFSRL 937 >gi|19743806 roundabout 1 isoform b [Homo sapiens] Length = 1612 Score = 110 bits (276), Expect = 6e-24 Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G Y C ++ G + +L VL P V P N V C A P Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 T W +D+ + + R I D +L++ D G YTCV N ++ ASA Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304 Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355 LTV P + +C NP P +F W ++G L + Sbjct: 305 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 362 Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409 +S G L I +G Y C N G T VT V+ PP I + Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422 Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465 V ++ C A G P P + W K G + Q Q++ N L +R Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481 Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510 G + C AS S + V T P+++ S + P+ +VS Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 539 Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564 W+P + G TP + + H W ++A V + GL+P+ Y Sbjct: 540 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 591 Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620 F V A N G S+I S P + P + G+ ++ L ++ + P Sbjct: 592 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 647 Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670 + +HW + + + GY + R G W EV PA + +++P L Sbjct: 648 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 702 Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730 K V YE + F F S T LE PS PQ V G Sbjct: 703 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 751 Query: 731 GVAVLVS 737 G A+LVS Sbjct: 752 GTAILVS 758 Score = 110 bits (274), Expect = 1e-23 Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%) Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78 D R P V V GE V+ C PP G P I W + G SP D Sbjct: 132 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 174 Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134 D +R G L I R D G Y C V + + E LTV Sbjct: 175 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 221 Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194 P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR Sbjct: 222 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 279 Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254 +V G G YTC A + G A + L V PP VV P++ V + V+ C A P Sbjct: 280 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 339 Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310 + W ++ S P R + G L + Q D G Y C N + Sbjct: 340 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 397 Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349 AYL V + P VIR V P+ + W KDG L Sbjct: 398 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 456 Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409 + Q G L I G Y+C G A S V P RP Sbjct: 457 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 516 Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466 + LIP + P V ++ L Q ++S +S I+ + + Sbjct: 517 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 566 Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494 W+ A N + + N Y VL TS V Sbjct: 567 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 626 Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539 + N +V++ V W Y+Q + + Y RP +H Sbjct: 627 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 680 Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596 DW+ V A + +++P L+ Y+ G SEI + T A Sbjct: 681 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 735 Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653 P PP + + G +L+ W PP +G V E + G E Sbjct: 736 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 786 Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707 ++ V G+ +++P L+ + Y + A AGS V + G V P Sbjct: 787 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 846 Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766 Q+ ++ QP +G C++ + ++ SI +R +R+ P F+ Sbjct: 847 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 905 Query: 767 PT 768 PT Sbjct: 906 PT 907 Score = 97.4 bits (241), Expect = 7e-20 Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G GVY C A + G A +A+ + + P + V + Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 + C T SW +D + R+ I G L + T+ DAG Y CV Sbjct: 147 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202 Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346 +N + S A LTVL P + +C R + P+ V W KD Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 261 Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406 L ++ T + G+ +G Y+C N +G A S V + PP F+ Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 316 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456 +P+++ +GR + C A G+P P + W + G + V L Sbjct: 317 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375 Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516 + + + G++ C N + T + V V+ + + +G V+ D Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 430 Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569 G ++ +P+ R D V ++ L G+ +Y +++ + Sbjct: 431 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 487 Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629 A G +S + G+P P P P IP S P V + V L W P Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 544 Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687 Y++E + G W+ + V TET + GL + +Y F + A Sbjct: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 602 Query: 688 VSDPSNTAN 696 +SDPS ++ Sbjct: 603 ISDPSQISD 611 Score = 41.2 bits (95), Expect = 0.006 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%) Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826 TG S S GS + S K +P + + W D P HP P S+ + Sbjct: 1107 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1166 Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873 E C P R + E E TP R A S + S Sbjct: 1167 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1221 Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914 SP QP+ C E+ PV+PPP PP P+ P Y+S P Sbjct: 1222 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1278 Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972 +M D D P EE M TRR LR E P S L +V G+ Sbjct: 1279 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1330 >gi|4506569 roundabout 1 isoform a [Homo sapiens] Length = 1651 Score = 110 bits (276), Expect = 6e-24 Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I Sbjct: 172 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 230 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G Y C ++ G + +L VL P V P N V C A P Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 T W +D+ + + R I D +L++ D G YTCV N ++ ASA Sbjct: 291 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 343 Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355 LTV P + +C NP P +F W ++G L + Sbjct: 344 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 401 Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409 +S G L I +G Y C N G T VT V+ PP I + Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461 Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465 V ++ C A G P P + W K G + Q Q++ N L +R Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520 Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510 G + C AS S + V T P+++ S + P+ +VS Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 578 Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564 W+P + G TP + + H W ++A V + GL+P+ Y Sbjct: 579 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 630 Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620 F V A N G S+I S P + P + G+ ++ L ++ + P Sbjct: 631 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 686 Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670 + +HW + + + GY + R G W EV PA + +++P L Sbjct: 687 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 741 Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730 K V YE + F F S T LE PS PQ V G Sbjct: 742 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 790 Query: 731 GVAVLVS 737 G A+LVS Sbjct: 791 GTAILVS 797 Score = 110 bits (274), Expect = 1e-23 Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%) Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78 D R P V V GE V+ C PP G P I W + G SP D Sbjct: 171 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 213 Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134 D +R G L I R D G Y C V + + E LTV Sbjct: 214 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 260 Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194 P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR Sbjct: 261 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 318 Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254 +V G G YTC A + G A + L V PP VV P++ V + V+ C A P Sbjct: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 378 Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310 + W ++ S P R + G L + Q D G Y C N + Sbjct: 379 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 436 Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349 AYL V + P VIR V P+ + W KDG L Sbjct: 437 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 495 Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409 + Q G L I G Y+C G A S V P RP Sbjct: 496 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 555 Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466 + LIP + P V ++ L Q ++S +S I+ + + Sbjct: 556 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 605 Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494 W+ A N + + N Y VL TS V Sbjct: 606 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 665 Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539 + N +V++ V W Y+Q + + Y RP +H Sbjct: 666 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 719 Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596 DW+ V A + +++P L+ Y+ G SEI + T A Sbjct: 720 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 774 Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653 P PP + + G +L+ W PP +G V E + G E Sbjct: 775 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 825 Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707 ++ V G+ +++P L+ + Y + A AGS V + G V P Sbjct: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 885 Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766 Q+ ++ QP +G C++ + ++ SI +R +R+ P F+ Sbjct: 886 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 944 Query: 767 PT 768 PT Sbjct: 945 PT 946 Score = 97.4 bits (241), Expect = 7e-20 Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 67 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G GVY C A + G A +A+ + + P + V + Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 + C T SW +D + R+ I G L + T+ DAG Y CV Sbjct: 186 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 241 Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346 +N + S A LTVL P + +C R + P+ V W KD Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 300 Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406 L ++ T + G+ +G Y+C N +G A S V + PP F+ Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 355 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456 +P+++ +GR + C A G+P P + W + G + V L Sbjct: 356 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414 Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516 + + + G++ C N + T + V V+ + + +G V+ D Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 469 Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569 G ++ +P+ R D V ++ L G+ +Y +++ + Sbjct: 470 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 526 Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629 A G +S + G+P P P P IP S P V + V L W P Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 583 Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687 Y++E + G W+ + V TET + GL + +Y F + A Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 641 Query: 688 VSDPSNTAN 696 +SDPS ++ Sbjct: 642 ISDPSQISD 650 Score = 41.2 bits (95), Expect = 0.006 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%) Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826 TG S S GS + S K +P + + W D P HP P S+ + Sbjct: 1146 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1205 Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873 E C P R + E E TP R A S + S Sbjct: 1206 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260 Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914 SP QP+ C E+ PV+PPP PP P+ P Y+S P Sbjct: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1317 Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972 +M D D P EE M TRR LR E P S L +V G+ Sbjct: 1318 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1369 >gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo sapiens] Length = 1183 Score = 110 bits (276), Expect = 6e-24 Identities = 157/645 (24%), Positives = 247/645 (38%), Gaps = 81/645 (12%) Query: 23 KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75 K ++ + ++G+S+VL C PP G PP +I W+ F LP + LY Sbjct: 143 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199 Query: 76 RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123 + P DY+ R ++Q + +V +D+ ++ + +F Sbjct: 200 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 252 Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181 + PP F +EL ++L C+A G P P + W L + + Sbjct: 253 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 309 Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241 + TL+I V SG Y C A + G+ H + V P + P+N ++ Sbjct: 310 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 369 Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300 +D +L C A P SW + + + I+ P +I DG + + Q + Y Sbjct: 370 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 425 Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341 C SN G L A+A++ VL P I P V AN P L + W Sbjct: 426 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 482 Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399 K G AL D + GT L I + +D+ G Y+C N LG A + +K Sbjct: 483 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 537 Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456 P +++P+ Q G + C + D V W K R L + L+ Sbjct: 538 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 596 Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516 + ++ + G + C A+ + V+ S + V+ L K +SW PG D Sbjct: 597 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDD 656 Query: 517 GGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575 + +F + Y +P HH ++ A L L P+ Y F V+A N +G Sbjct: 657 NNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYSFRVMAVNSIG 712 Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620 SE A E T + P PT + S P LV P Sbjct: 713 KSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 753 Score = 106 bits (264), Expect = 1e-22 Identities = 188/807 (23%), Positives = 295/807 (36%), Gaps = 175/807 (21%) Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102 L+ A P I WL G +PI I S +ID D + +Q+ +S Sbjct: 374 LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 423 Query: 103 QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162 Y+C ++ + F N + PP+ + +V P L C G Sbjct: 424 ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 474 Query: 163 SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221 SPLP + W K + V +NGTL I ++ S+G YTC A + G A + L Sbjct: 475 SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534 Query: 222 LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280 + P IV P+ + V VS C + + +LT W +DN L R Sbjct: 535 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 588 Query: 281 LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPL--- 336 VD ++A DD+G YTCV +N L SASA L+V+ +P NPP Sbjct: 589 TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVDVP---------NPPFDLE 638 Query: 337 --------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDALGE 376 + +SWT D + KF PG W TE S + Sbjct: 639 LTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTTAQ 692 Query: 377 YSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA 426 +PY NS+G + PS + E+Y + P + Sbjct: 693 LKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPTAV 737 Query: 427 QG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSASNA 475 +G +P V++W + G GLQ + K+ W +N Sbjct: 738 EGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVANV 787 Query: 476 VARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA--------------N 508 + + T +V P VV S LP A Sbjct: 788 SKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAE 847 Query: 509 VSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQ 563 V W+P G+LQ + ++Y T + + +R H + L H ++PGL+P + Sbjct: 848 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907 Query: 564 YQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRG 622 Y +V N G GP S + V + PEG+P+ P++ + + P L Sbjct: 908 YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD------------S 951 Query: 623 VLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYEFR 679 + L WDPP L Y L+ + + E ++D + +T + L Y+F Sbjct: 952 LTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFY 1011 Query: 680 LVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSIL 739 A S S T T+ E SR + +G +C + + +L+ +L Sbjct: 1012 FYA-QTSAGSGSQITEEAVTTVDEAMASRQ-----VDIATQGWFIGLMCAVALLILI-LL 1064 Query: 740 AGCLLNRRRAAR---RRRKRLRQDPPL 763 C + R + + + ++ DP + Sbjct: 1065 IVCFIRRNKGGKYPVKEKEDAHADPEI 1091 Score = 58.5 bits (140), Expect = 4e-08 Identities = 94/428 (21%), Positives = 157/428 (36%), Gaps = 66/428 (15%) Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187 V L + PP + P + E + ++C A+G P P +W G + + Sbjct: 32 VPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 91 Query: 188 ---NGTLRIRRVERGSS----GVYTCQASSTEGSAT------------------------ 216 GTL I + G + GVY C A + G+A Sbjct: 92 KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL 151 Query: 217 HATQLLVL--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------L 257 + Q LVL PP+ + PP NS + S+ VS + + Y +N + Sbjct: 152 QSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 211 Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPS 312 Y+ F + + +V I VD +A D Y P L + Sbjct: 212 CYARFNHTQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 270 Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372 AS + + C + P + W K+ L ++ + E +L I +E Sbjct: 271 ASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEA 327 Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432 G Y C N+LG + RV KA P +I P + G + + C A G+P P Sbjct: 328 DSGNYQCIAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKP 384 Query: 433 VVSWTKVGRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVL 488 +SW G ++ ++ ++I + + + ++C+ASN + + V VL Sbjct: 385 RISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL 444 Query: 489 GTSPHVVT 496 P ++T Sbjct: 445 AEPPRILT 452 >gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo sapiens] Length = 1304 Score = 110 bits (275), Expect = 8e-24 Identities = 159/655 (24%), Positives = 250/655 (38%), Gaps = 91/655 (13%) Query: 23 KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75 K ++ + ++G+S+VL C PP G PP +I W+ F LP + LY Sbjct: 149 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 205 Query: 76 RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123 + P DY+ R ++Q + +V +D+ ++ + +F Sbjct: 206 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 258 Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181 + PP F +EL ++L C+A G P P + W L + + Sbjct: 259 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 315 Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241 + TL+I V SG Y C A + G+ H + V P + P+N ++ Sbjct: 316 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 375 Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300 +D +L C A P SW + + + I+ P +I DG + + Q + Y Sbjct: 376 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 431 Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341 C SN G L A+A++ VL P I P V AN P L + W Sbjct: 432 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 488 Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399 K G AL D + GT L I + +D+ G Y+C N LG A + +K Sbjct: 489 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 543 Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456 P +++P+ Q G + C + D V W K R L + L+ Sbjct: 544 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 602 Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVV----------ALPKG 506 + ++ + G + C A+ + V+ S + V+ +P V L K Sbjct: 603 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKS 662 Query: 507 ANVSWEPGFDGGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQ 565 +SW PG D + +F + Y +P HH ++ A L L P+ Y Sbjct: 663 VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYS 718 Query: 566 FSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620 F V+A N +G SE A E T + P PT + S P LV P Sbjct: 719 FRVMAVNSIGKSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 769 Score = 105 bits (262), Expect = 3e-22 Identities = 185/770 (24%), Positives = 279/770 (36%), Gaps = 168/770 (21%) Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102 L+ A P I WL G +PI I S +ID D + +Q+ +S Sbjct: 380 LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 429 Query: 103 QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162 Y+C ++ + F N + PP+ + +V P L C G Sbjct: 430 ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 480 Query: 163 SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221 SPLP + W K + V +NGTL I ++ S+G YTC A + G A + L Sbjct: 481 SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 540 Query: 222 LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280 + P IV P+ + V VS C + + +LT W +DN L R Sbjct: 541 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 594 Query: 281 LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR--ANPPL- 336 VD ++A DD+G YTCV +N L SASA L+V+ P PV NPP Sbjct: 595 TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVA-PTPTPAPVYDVPNPPFD 652 Query: 337 ----------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDAL 374 + +SWT D + KF PG W TE S Sbjct: 653 LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTT 706 Query: 375 GEYSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424 + +PY NS+G + PS + E+Y + P Sbjct: 707 AQLKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPT 751 Query: 425 SAQG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSAS 473 + +G +P V++W + G GLQ + K+ W + Sbjct: 752 AVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVA 801 Query: 474 NAVARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA------------- 507 N + + T +V P VV S LP A Sbjct: 802 NVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTL 861 Query: 508 -NVSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561 V W+P G+LQ + ++Y T + + +R H + L H ++PGL+P Sbjct: 862 AEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPF 921 Query: 562 TQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620 + Y +V N G GP S + V + PEG+P+ P++ + + P L Sbjct: 922 SHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD----------- 966 Query: 621 RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYE 677 + L WDPP L Y L+ + + E ++D + +T + L Y+ Sbjct: 967 -SLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYK 1025 Query: 678 FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727 F A +A + E + G+LP V AG V V Sbjct: 1026 FYFYA---------QTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAV 1066 Score = 57.4 bits (137), Expect = 8e-08 Identities = 92/421 (21%), Positives = 154/421 (36%), Gaps = 66/421 (15%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ---NGTL 191 PP + P + E + ++C A+G P P +W G + + GTL Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104 Query: 192 RIRRVERGSS----GVYTCQASSTEGSAT------------------------HATQLLV 223 I + G + GVY C A + G+A + Q LV Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164 Query: 224 L--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------LTYSWFQD 264 L PP+ + PP NS + S+ VS + + Y +N + Y+ F Sbjct: 165 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNH 224 Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPSASAYLTV 319 + + +V I VD +A D Y P L +AS + Sbjct: 225 TQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 283 Query: 320 LCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSC 379 + C + P + W K+ L ++ + E +L I +E G Y C Sbjct: 284 RGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEADSGNYQC 340 Query: 380 TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKV 439 N+LG + RV KA P +I P + G + + C A G+P P +SW Sbjct: 341 IAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKPRISWLTN 397 Query: 440 GRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495 G ++ ++ ++I + + + ++C+ASN + + V VL P ++ Sbjct: 398 GVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRIL 457 Query: 496 T 496 T Sbjct: 458 T 458 Score = 40.4 bits (93), Expect = 0.010 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 18/103 (17%) Query: 398 LKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLIL 457 L PP ++ ++Y + ++I C A+G PPP SWT+ G +D + + + Sbjct: 42 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGT----HFDIDKDPLVTM 97 Query: 458 RPLT-------------KEAHGHWECSASNAVARVATSTNVYV 487 +P T + G ++C+A N A S N+ V Sbjct: 98 KPGTGTLIINIMSEGKAETYEGVYQCTARNE-RGAAVSNNIVV 139 >gi|224994173 roundabout 1 isoform d [Homo sapiens] Length = 1551 Score = 108 bits (270), Expect = 3e-23 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G Y C ++ G + +L VL P V P N V C A P Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 T W +D+ + + R I D +L++ D G YTCV N ++ ASA Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304 Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355 LTV L +C NP P +F W ++G L + Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362 Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406 +S G L I +G Y C N G T VT V+ PP I Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463 + V ++ C A G P P + W K G + Q + N L +R Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482 Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509 G + C AS S + V T P+++ S + P+ +V Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540 Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562 SW+P + G TP + + H W ++A V + GL+P+ Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592 Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620 Y F V A N G S+I S P + P + G+ ++ L ++ + P Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648 Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668 + +HW + + + GY + R G W EV PA + +++P Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703 Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728 L K V YE + F F S T LE PS PQ V G Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753 Query: 729 FLGVAVLVS 737 G A+LVS Sbjct: 754 -NGTAILVS 761 Score = 97.1 bits (240), Expect = 9e-20 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G GVY C A + G A +A+ + + P + V + Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 + C T SW +D + R+ I G L + T+ DAG Y CV Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202 Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346 +N + S A LTVL P ++ C R +P + V W KD Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261 Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405 L ++ T + G+ +G Y+C N +G A S V + + PP F+ Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455 +P+++ +GR + C A G+P P + W + G + V L Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377 Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515 + + + G++ C N + T + V V+ + + +G V+ Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432 Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568 DG ++ +P+ R D V ++ L G+ +Y +++ Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489 Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628 +A G +S + G+P P P P IP S P V + V L W Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546 Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686 P Y++E + G W+ + V TET + GL + +Y F + A Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604 Query: 687 FVSDPSNTAN 696 +SDPS ++ Sbjct: 605 GISDPSQISD 614 Score = 65.5 bits (158), Expect = 3e-10 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G +V C+ A P I W R G +F Y P P R + + L Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 I ++ D G+Y C+ + I + + V + PP P V Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435 Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212 L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+ Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495 Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267 G AT + + V V V PP+ + N N +T SW Q N+N Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550 Score = 41.2 bits (95), Expect = 0.006 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%) Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826 TG S S GS + S K +P + + W D P HP P S+ + Sbjct: 1046 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1105 Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873 E C P R + E E TP R A S + S Sbjct: 1106 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1160 Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914 SP QP+ C E+ PV+PPP PP P+ P Y+S P Sbjct: 1161 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1217 Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972 +M D D P EE M TRR LR E P S L +V G+ Sbjct: 1218 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1269 >gi|224994171 roundabout 1 isoform c [Homo sapiens] Length = 1606 Score = 108 bits (270), Expect = 3e-23 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G Y C ++ G + +L VL P V P N V C A P Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 T W +D+ + + R I D +L++ D G YTCV N ++ ASA Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304 Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355 LTV L +C NP P +F W ++G L + Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362 Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406 +S G L I +G Y C N G T VT V+ PP I Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463 + V ++ C A G P P + W K G + Q + N L +R Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482 Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509 G + C AS S + V T P+++ S + P+ +V Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540 Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562 SW+P + G TP + + H W ++A V + GL+P+ Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592 Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620 Y F V A N G S+I S P + P + G+ ++ L ++ + P Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648 Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668 + +HW + + + GY + R G W EV PA + +++P Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703 Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728 L K V YE + F F S T LE PS PQ V G Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753 Query: 729 FLGVAVLVS 737 G A+LVS Sbjct: 754 -NGTAILVS 761 Score = 97.1 bits (240), Expect = 9e-20 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G GVY C A + G A +A+ + + P + V + Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 + C T SW +D + R+ I G L + T+ DAG Y CV Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202 Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346 +N + S A LTVL P ++ C R +P + V W KD Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261 Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405 L ++ T + G+ +G Y+C N +G A S V + + PP F+ Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455 +P+++ +GR + C A G+P P + W + G + V L Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377 Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515 + + + G++ C N + T + V V+ + + +G V+ Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432 Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568 DG ++ +P+ R D V ++ L G+ +Y +++ Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489 Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628 +A G +S + G+P P P P IP S P V + V L W Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546 Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686 P Y++E + G W+ + V TET + GL + +Y F + A Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604 Query: 687 FVSDPSNTAN 696 +SDPS ++ Sbjct: 605 GISDPSQISD 614 Score = 65.5 bits (158), Expect = 3e-10 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G +V C+ A P I W R G +F Y P P R + + L Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 I ++ D G+Y C+ + I + + V + PP P V Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435 Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212 L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+ Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495 Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267 G AT + + V V V PP+ + N N +T SW Q N+N Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550 Score = 41.2 bits (95), Expect = 0.006 Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%) Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826 TG S S GS + S K +P + + W D P HP P S+ + Sbjct: 1101 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1160 Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873 E C P R + E E TP R A S + S Sbjct: 1161 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1215 Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914 SP QP+ C E+ PV+PPP PP P+ P Y+S P Sbjct: 1216 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1272 Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972 +M D D P EE M TRR LR E P S L +V G+ Sbjct: 1273 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1324 >gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo sapiens] Length = 1562 Score = 108 bits (270), Expect = 3e-23 Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%) Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196 F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191 Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255 + +G Y C ++ G + +L VL P V P N V C A P Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251 Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315 T W +D+ + + R I D +L++ D G YTCV N ++ ASA Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304 Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355 LTV L +C NP P +F W ++G L + Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362 Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406 +S G L I +G Y C N G T VT V+ PP I Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422 Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463 + V ++ C A G P P + W K G + Q + N L +R Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482 Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509 G + C AS S + V T P+++ S + P+ +V Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540 Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562 SW+P + G TP + + H W ++A V + GL+P+ Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592 Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620 Y F V A N G S+I S P + P + G+ ++ L ++ + P Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648 Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668 + +HW + + + GY + R G W EV PA + +++P Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703 Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728 L K V YE + F F S T LE PS PQ V G Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753 Query: 729 FLGVAVLVS 737 G A+LVS Sbjct: 754 -NGTAILVS 761 Score = 97.1 bits (240), Expect = 9e-20 Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%) Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189 PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242 +L R+ G GVY C A + G A +A+ + + P + V + Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302 + C T SW +D + R+ I G L + T+ DAG Y CV Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202 Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346 +N + S A LTVL P ++ C R +P + V W KD Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261 Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405 L ++ T + G+ +G Y+C N +G A S V + + PP F+ Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318 Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455 +P+++ +GR + C A G+P P + W + G + V L Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377 Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515 + + + G++ C N + T + V V+ + + +G V+ Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432 Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568 DG ++ +P+ R D V ++ L G+ +Y +++ Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489 Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628 +A G +S + G+P P P P IP S P V + V L W Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546 Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686 P Y++E + G W+ + V TET + GL + +Y F + A Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604 Query: 687 FVSDPSNTAN 696 +SDPS ++ Sbjct: 605 GISDPSQISD 614 Score = 65.5 bits (158), Expect = 3e-10 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%) Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93 G +V C+ A P I W R G +F Y P P R + + L Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377 Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153 I ++ D G+Y C+ + I + + V + PP P V Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435 Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212 L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+ Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495 Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267 G AT + + V V V PP+ + N N +T SW Q N+N Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550 Score = 42.0 bits (97), Expect = 0.003 Identities = 65/238 (27%), Positives = 80/238 (33%), Gaps = 47/238 (19%) Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826 TG S S GS + S K +P + + W D P HP P S+ + Sbjct: 1057 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1116 Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873 E C P R T E E TP R A S + S Sbjct: 1117 VDESYDQEMPCPVPPAR-----TYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1171 Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914 SP QP+ C E+ PV+PPP PP P+ P Y+S P Sbjct: 1172 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1228 Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972 +M D D P EE M TRR LR E P S L +V G+ Sbjct: 1229 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1280 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.136 0.426 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 59,029,305 Number of Sequences: 37866 Number of extensions: 3727163 Number of successful extensions: 34998 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 246 Number of HSP's successfully gapped in prelim test: 1244 Number of HSP's that attempted gapping in prelim test: 19898 Number of HSP's gapped (non-prelim): 10936 length of query: 1163 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1050 effective length of database: 13,968,660 effective search space: 14667093000 effective search space used: 14667093000 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.