Search of human proteins with 20357504

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
         (3062 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]            6042   0.0  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]            2402   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                       2291   0.0  
gi|221316622 dystonin isoform 3 [Homo sapiens]                       2291   0.0  
gi|221316618 dystonin isoform 2 [Homo sapiens]                       2291   0.0  
gi|34577047 dystonin isoform 1 [Homo sapiens]                        2291   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]              2191   0.0  
gi|33188445 microfilament and actin filament cross-linker protei...  1111   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       787   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       787   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        787   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        787   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        787   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        787   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        787   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        787   0.0  
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   667   0.0  
gi|58530842 desmoplakin isoform II [Homo sapiens]                     596   e-169
gi|58530840 desmoplakin isoform I [Homo sapiens]                      561   e-159
gi|33188443 microfilament and actin filament cross-linker protei...   316   2e-85
gi|45439327 periplakin [Homo sapiens]                                 283   2e-75
gi|156104874 envoplakin [Homo sapiens]                                190   2e-47
gi|207452735 epiplakin 1 [Homo sapiens]                                92   6e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    91   2e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    88   1e-16
gi|55770834 centromere protein F [Homo sapiens]                        87   3e-16
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...    83   4e-15
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    83   4e-15
gi|71061468 centromere protein E [Homo sapiens]                        82   1e-14
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         80   4e-14

>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score = 6042 bits (15675), Expect = 0.0
 Identities = 3062/3062 (100%), Positives = 3062/3062 (100%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140
            YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140

Query: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200
            GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN
Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200

Query: 1201 LLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRL 1260
            LLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRL
Sbjct: 1201 LLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRL 1260

Query: 1261 LETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLD 1320
            LETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLD
Sbjct: 1261 LETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLD 1320

Query: 1321 ALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMC 1380
            ALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMC
Sbjct: 1321 ALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMC 1380

Query: 1381 KDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGL 1440
            KDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGL
Sbjct: 1381 KDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGL 1440

Query: 1441 IDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQS 1500
            IDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQS
Sbjct: 1441 IDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQS 1500

Query: 1501 NPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELA 1560
            NPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELA
Sbjct: 1501 NPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELA 1560

Query: 1561 YKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACK 1620
            YKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACK
Sbjct: 1561 YKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACK 1620

Query: 1621 NARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQ 1680
            NARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQ
Sbjct: 1621 NARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQ 1680

Query: 1681 RLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPS 1740
            RLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPS
Sbjct: 1681 RLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPS 1740

Query: 1741 SFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPS 1800
            SFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPS
Sbjct: 1741 SFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPS 1800

Query: 1801 VCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDL 1860
            VCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDL
Sbjct: 1801 VCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDL 1860

Query: 1861 IENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTP 1920
            IENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTP
Sbjct: 1861 IENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTP 1920

Query: 1921 ESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNP 1980
            ESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNP
Sbjct: 1921 ESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNP 1980

Query: 1981 QVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCA 2040
            QVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCA
Sbjct: 1981 QVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCA 2040

Query: 2041 TPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLH 2100
            TPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLH
Sbjct: 2041 TPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLH 2100

Query: 2101 PEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEK 2160
            PEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEK
Sbjct: 2101 PEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEK 2160

Query: 2161 DELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASL 2220
            DELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASL
Sbjct: 2161 DELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASL 2220

Query: 2221 KFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGG 2280
            KFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGG
Sbjct: 2221 KFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGG 2280

Query: 2281 GIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNV 2340
            GIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNV
Sbjct: 2281 GIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNV 2340

Query: 2341 VQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPA 2400
            VQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPA
Sbjct: 2341 VQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPA 2400

Query: 2401 SISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHI 2460
            SISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHI
Sbjct: 2401 SISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHI 2460

Query: 2461 ICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGE 2520
            ICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGE
Sbjct: 2461 ICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGE 2520

Query: 2521 GEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLK 2580
            GEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLK
Sbjct: 2521 GEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLK 2580

Query: 2581 DEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKE 2640
            DEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKE
Sbjct: 2581 DEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKE 2640

Query: 2641 LDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSP 2700
            LDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSP
Sbjct: 2641 LDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSP 2700

Query: 2701 LNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANG 2760
            LNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANG
Sbjct: 2701 LNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANG 2760

Query: 2761 LGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKD 2820
            LGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKD
Sbjct: 2761 LGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKD 2820

Query: 2821 ILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGV 2880
            ILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGV
Sbjct: 2821 ILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGV 2880

Query: 2881 SPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEK 2940
            SPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEK
Sbjct: 2881 SPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEK 2940

Query: 2941 RGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEG 3000
            RGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEG
Sbjct: 2941 RGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEG 3000

Query: 3001 NYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQ 3060
            NYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQ
Sbjct: 3001 NYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQ 3060

Query: 3061 VS 3062
            VS
Sbjct: 3061 VS 3062


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 2402 bits (6225), Expect = 0.0
 Identities = 1224/1225 (99%), Positives = 1225/1225 (100%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140
            YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140

Query: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200
            GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN
Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200

Query: 1201 LLFSESLKQLQESQTSGDVKVEEKL 1225
            LLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1201 LLFSESLKQLQESQTSGDVKVEEKI 1225



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3189 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3248

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3249 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3301

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3302 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3356

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3357 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3400

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 3401 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3458

Query: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3459 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3511

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3512 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3561

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3562 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3614

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3615 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3671

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 3672 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 3731

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 3732 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 3836

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 3893

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 3953

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 3954 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4005

Query: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 4006 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4059

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 4060 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4106

Query: 1234 DQTTGEVLSVFQAV 1247
             +T  E L+V   V
Sbjct: 4107 PETAKEQLNVHMEV 4120



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 630  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 689  RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 749  IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 809  SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 859  EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 914

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 970

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 971  DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1029

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1086

Query: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 1087 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1146

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 1147 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206

Query: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 1207 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1265

Query: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 1266 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1325

Query: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1326 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1379

Query: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1380 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1438

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1439 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1498

Query: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
            S K+++ + +     ++E+L+K
Sbjct: 1499 SEKKMKLTHS-----LQEELEK 1515



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 3882 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 3928

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 3929 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 3985

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 3986 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4019

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4020 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4077

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4135

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4136 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4190

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4191 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4236

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4237 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4290

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4291 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4350

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4351 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4409

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4410 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4462

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4463 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4519

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 4520 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4578

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 4579 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4638

Query: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 4639 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 4686



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 110/566 (19%), Positives = 239/566 (42%), Gaps = 52/566 (9%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 2894

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 2895 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3008

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3009 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3064

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 3065 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124

Query: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 3125 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3183

Query: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q   ++ + L + + E 
Sbjct: 3184 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ--DYSTEGLWKQQSEL 3241

Query: 1107 KSLEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
            + L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T
Sbjct: 3242 RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3301

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
                L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      
Sbjct: 3302 ----LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPK 3351

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            ++K E K +K +  ++++ +  +L +
Sbjct: 3352 ELKKEAKNNKALLDSLNEVSSALLEL 3377



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 852  LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 896

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 897  DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 953

Query: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 954  NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1073

Query: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 1074 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1125

Query: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 1126 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1162

Query: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 1163 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1203

Query: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 1204 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1263

Query: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 1264 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1323

Query: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 1324 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1381

Query: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 1382 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1441

Query: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 1442 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1500

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 1501 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1560

Query: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 1561 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1620

Query: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 1621 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 1680

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 1681 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 1733

Query: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 1734 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 1793

Query: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 1794 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 1853

Query: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            T   V++ E L + +   ++  T  +  V
Sbjct: 1854 TK--VELFENLSEKLQTFLETKTQALTEV 1880



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 3317 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3376

Query: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 3377 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3436

Query: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 3437 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3496

Query: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 3497 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3555

Query: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 3556 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3615

Query: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 3616 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 3665

Query: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 3666 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 3725

Query: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 3726 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 3777

Query: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 3778 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 3835

Query: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 3836 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 3895

Query: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 3896 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955

Query: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015

Query: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 4016 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4066

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 4067 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4123

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 4124 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4157

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 4158 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4203

Query: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 4204 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4263

Query: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 4264 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4320



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1525 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1584

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1585 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1644

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 1645 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 1700

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 1701 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 1756

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 1757 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 1814

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 1815 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 1920

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 1921 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 1979

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 1980 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2035

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2036 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2070

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2071 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2121

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2122 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2181

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2182 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2239

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 2240 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2299

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 2300 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2359

Query: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 2360 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2418

Query: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 2419 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2478

Query: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
            D  K    + +  E   KT+ E  NLL
Sbjct: 2479 DFSKTLTAQSHMYE---KTIAEGENLL 2502



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2329 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2385

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2386 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2445

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 2446 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2505

Query: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 2506 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2565

Query: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 2566 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2625

Query: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 2626 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 2685

Query: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 2686 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 2745

Query: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 2746 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 2800

Query: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 2801 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 2857

Query: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
              Q +E Q  G +K +EE   K+
Sbjct: 2858 --QAREEQVEGTIKRLEEFYSKL 2878



 Score = 40.0 bits (92), Expect = 0.035
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4096 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4155

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4216 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4265

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4266 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4296

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4297 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4357 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4414

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4415 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4463

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4464 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4515

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4516 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4572

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4573 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4628

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4629 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 4683

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 4684 TYKRRAAD 4691


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 2291 bits (5938), Expect = 0.0
 Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 411  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 470

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 471  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 530

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 531  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 590

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 591  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 650

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 651  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 710

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 711  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 770

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 771  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 830

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 831  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 890

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 891  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 950

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 951  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1010

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1011 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1070

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1250

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1251 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1310

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1311 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1370

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1430

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1490

Query: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1491 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1550

Query: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
            QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1551 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1580



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3603

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3604 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3656

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3657 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3711

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3712 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3755

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 3756 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3813

Query: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3814 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3866

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3867 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3916

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3917 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3969

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3970 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4026

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4027 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4086

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4087 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4191

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4248

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4308

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 4309 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4360

Query: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 4361 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4414

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 4415 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4461

Query: 1234 DQTTGEVLSVFQAV 1247
             +T  E L+V   V
Sbjct: 4462 PETAKEQLNVHMEV 4475



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 985  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1043

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 1044 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1103

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 1104 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1163

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 1164 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1213

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 1214 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1269

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 1270 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1325

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 1326 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1384

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 1385 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1441

Query: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 1442 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1501

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 1502 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1561

Query: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 1562 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1620

Query: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 1621 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1680

Query: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1681 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1734

Query: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1735 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1793

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1794 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1853

Query: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
            S K+++ + +     ++E+L+K
Sbjct: 1854 SEKKMKLTHS-----LQEELEK 1870



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4237 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4283

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4284 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4340

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4341 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4374

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4375 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4432

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4490

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4491 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4545

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4591

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4592 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4645

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4646 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4705

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4706 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4764

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4765 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4817

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4818 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4874

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 4875 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4933

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 4934 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4993

Query: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 4994 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5041



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 110/566 (19%), Positives = 239/566 (42%), Gaps = 52/566 (9%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3249

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3250 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3363

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3364 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 3420 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479

Query: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 3480 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3538

Query: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q   ++ + L + + E 
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ--DYSTEGLWKQQSEL 3596

Query: 1107 KSLEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
            + L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T
Sbjct: 3597 RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
                L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      
Sbjct: 3657 ----LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPK 3706

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            ++K E K +K +  ++++ +  +L +
Sbjct: 3707 ELKKEAKNNKALLDSLNEVSSALLEL 3732



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 1207 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1251

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 1252 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1308

Query: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 1309 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1368

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 1369 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1428

Query: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 1429 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1480

Query: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 1481 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1517

Query: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 1518 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1558

Query: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 1559 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1618

Query: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 1619 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1678

Query: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1736

Query: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 1737 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1796

Query: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 1797 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1855

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 1856 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1915

Query: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 1916 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1975

Query: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 1976 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2035

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 2036 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2088

Query: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 2089 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2148

Query: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 2149 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2208

Query: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            T   V++ E L + +   ++  T  +  V
Sbjct: 2209 TK--VELFENLSEKLQTFLETKTQALTEV 2235



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 3672 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3731

Query: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 3732 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3791

Query: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 3792 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3851

Query: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 3852 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3910

Query: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 3911 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3970

Query: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 3971 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 4020

Query: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 4021 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4080

Query: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 4081 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4132

Query: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 4133 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4190

Query: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 4191 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4250

Query: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 4251 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310

Query: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370

Query: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 4371 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4421

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 4422 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4478

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 4479 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4512

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 4513 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4558

Query: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 4559 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4618

Query: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 4619 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4675



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1880 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1939

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1940 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1999

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2000 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2055

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2056 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2111

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2112 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2169

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2170 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2275

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2276 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2334

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2335 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2390

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2391 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2425

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2426 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2476

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2537 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2594

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 2595 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2654

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 2655 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2714

Query: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 2715 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2773

Query: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 2774 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2833

Query: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
            D  K    + +  E   KT+ E  NLL
Sbjct: 2834 DFSKTLTAQSHMYE---KTIAEGENLL 2857



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2684 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2740

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2741 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2800

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 2801 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2860

Query: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 2861 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2920

Query: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 2921 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2980

Query: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 2981 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3040

Query: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 3041 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3100

Query: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 3101 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3155

Query: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 3156 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3212

Query: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
              Q +E Q  G +K +EE   K+
Sbjct: 3213 --QAREEQVEGTIKRLEEFYSKL 3233



 Score = 40.0 bits (92), Expect = 0.035
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4571 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4620

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4621 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4651

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4769

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4770 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4818

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4819 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4870

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4871 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4927

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4928 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4983

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4984 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5038

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5039 TYKRRAAD 5046


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 2291 bits (5938), Expect = 0.0
 Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 422  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 482  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 542  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 602  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 662  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 722  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 782  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 842  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 902  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 962  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501

Query: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561

Query: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
            QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1591



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3615 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3667

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3722

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3723 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3766

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 3767 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3824

Query: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3825 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3877

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3878 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3927

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3928 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3980

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4037

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4038 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4098 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4202

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4259

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4319

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 4320 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4371

Query: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 4372 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4425

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 4426 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4472

Query: 1234 DQTTGEVLSVFQAV 1247
             +T  E L+V   V
Sbjct: 4473 PETAKEQLNVHMEV 4486



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 996  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1054

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 1055 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1114

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 1115 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1174

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 1175 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1224

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 1225 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1280

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 1281 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1336

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 1337 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1395

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 1396 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1452

Query: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 1453 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1512

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 1513 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1572

Query: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 1573 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631

Query: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1691

Query: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1692 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1745

Query: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1746 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1804

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1805 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1864

Query: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
            S K+++ + +     ++E+L+K
Sbjct: 1865 SEKKMKLTHS-----LQEELEK 1881



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4294

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4295 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4351

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4352 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4385

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4386 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4501

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4502 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4602

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4603 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4656

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4657 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4716

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4717 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4775

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4776 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4828

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4829 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 4886 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 4945 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5004

Query: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 5005 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5052



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 110/566 (19%), Positives = 239/566 (42%), Gaps = 52/566 (9%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3261 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3374

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3375 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490

Query: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 3491 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549

Query: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q   ++ + L + + E 
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ--DYSTEGLWKQQSEL 3607

Query: 1107 KSLEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
            + L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T
Sbjct: 3608 RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
                L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      
Sbjct: 3668 ----LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPK 3717

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            ++K E K +K +  ++++ +  +L +
Sbjct: 3718 ELKKEAKNNKALLDSLNEVSSALLEL 3743



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 1218 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1262

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 1263 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1319

Query: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1379

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1439

Query: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 1440 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1491

Query: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 1492 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1528

Query: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 1529 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1569

Query: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 1570 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1629

Query: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689

Query: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1747

Query: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 1748 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1807

Query: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 1808 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1866

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 1867 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1926

Query: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 1927 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1986

Query: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 1987 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2046

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 2047 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099

Query: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2159

Query: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 2160 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2219

Query: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            T   V++ E L + +   ++  T  +  V
Sbjct: 2220 TK--VELFENLSEKLQTFLETKTQALTEV 2246



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 3683 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3742

Query: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3802

Query: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 3803 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3862

Query: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3921

Query: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 3922 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3981

Query: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 3982 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 4031

Query: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 4032 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4091

Query: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 4092 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4143

Query: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4201

Query: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4261

Query: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321

Query: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381

Query: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 4382 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4432

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 4433 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4489

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 4490 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4523

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 4524 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569

Query: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 4570 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4629

Query: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 4630 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4686



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1891 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1950

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1951 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2010

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2011 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2067 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2123 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2180

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2181 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2286

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2287 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2401

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2402 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2436

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2437 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2487

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2548 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2605

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2725

Query: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 2726 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2784

Query: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 2785 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2844

Query: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
            D  K    + +  E   KT+ E  NLL
Sbjct: 2845 DFSKTLTAQSHMYE---KTIAEGENLL 2868



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2751

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2752 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 2812 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2871

Query: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 2872 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2931

Query: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 2932 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2991

Query: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 2992 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3051

Query: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 3052 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3111

Query: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 3112 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3166

Query: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 3167 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3223

Query: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
              Q +E Q  G +K +EE   K+
Sbjct: 3224 --QAREEQVEGTIKRLEEFYSKL 3244



 Score = 40.0 bits (92), Expect = 0.035
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4582 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4631

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4632 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4662

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4780

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4781 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4829

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4830 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4881

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4938

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4939 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4994

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4995 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5050 TYKRRAAD 5057


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 2291 bits (5938), Expect = 0.0
 Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 560  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 619

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 620  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 679

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 680  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 739

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 740  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 799

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 800  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 859

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 860  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 919

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 920  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 979

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 980  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 1039

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 1040 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 1099

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 1100 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1159

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1160 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1219

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1519

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639

Query: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1640 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1699

Query: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
            QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1700 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1729



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3752

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3753 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3805

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3806 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3860

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3861 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3904

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 3905 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3962

Query: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3963 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 4015

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 4016 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 4065

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 4066 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 4118

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 4119 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4175

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4176 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4235

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4236 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4340

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4397

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4457

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 4458 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4509

Query: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 4510 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4563

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 4564 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4610

Query: 1234 DQTTGEVLSVFQAV 1247
             +T  E L+V   V
Sbjct: 4611 PETAKEQLNVHMEV 4624



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 1134 EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1192

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 1193 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1252

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 1253 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1312

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 1313 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1362

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 1363 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1418

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 1419 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1474

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 1475 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1533

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 1534 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1590

Query: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 1591 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1650

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 1651 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1710

Query: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 1711 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1769

Query: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 1770 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1829

Query: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1830 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1883

Query: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1884 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1942

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1943 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 2002

Query: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
            S K+++ + +     ++E+L+K
Sbjct: 2003 SEKKMKLTHS-----LQEELEK 2019



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4386 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4432

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4433 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4489

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4490 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4523

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4524 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4581

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4639

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4640 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4694

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4740

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4741 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4794

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4795 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4854

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4855 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4913

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4914 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4966

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4967 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 5023

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 5024 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 5082

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 5083 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5142

Query: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 5143 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5190



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 110/566 (19%), Positives = 239/566 (42%), Gaps = 52/566 (9%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3398

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3399 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3512

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3513 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 3569 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628

Query: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 3629 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3687

Query: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q   ++ + L + + E 
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ--DYSTEGLWKQQSEL 3745

Query: 1107 KSLEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
            + L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T
Sbjct: 3746 RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
                L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      
Sbjct: 3806 ----LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPK 3855

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            ++K E K +K +  ++++ +  +L +
Sbjct: 3856 ELKKEAKNNKALLDSLNEVSSALLEL 3881



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 1356 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1400

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 1401 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1457

Query: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 1458 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1517

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 1518 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1577

Query: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 1578 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1629

Query: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 1630 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1666

Query: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 1667 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1707

Query: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 1708 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1767

Query: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 1768 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1827

Query: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1885

Query: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 1886 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1945

Query: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 1946 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 2004

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 2005 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 2064

Query: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 2065 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 2124

Query: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 2125 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2184

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 2185 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2237

Query: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 2238 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2297

Query: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 2298 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2357

Query: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            T   V++ E L + +   ++  T  +  V
Sbjct: 2358 TK--VELFENLSEKLQTFLETKTQALTEV 2384



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 3821 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3880

Query: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 3881 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3940

Query: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 3941 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 4000

Query: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 4001 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 4059

Query: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 4060 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 4119

Query: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 4120 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 4169

Query: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 4170 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4229

Query: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 4230 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4281

Query: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 4282 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4339

Query: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 4340 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4399

Query: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 4400 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459

Query: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519

Query: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 4520 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4570

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 4571 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4627

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 4628 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4661

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 4662 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4707

Query: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 4708 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4767

Query: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 4768 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4824



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 2029 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 2088

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 2089 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2148

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2149 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2204

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2205 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2260

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2261 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2318

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2319 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2424

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2425 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2483

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2484 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2539

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2540 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2574

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2575 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2625

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2686 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2743

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 2744 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2803

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 2804 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2863

Query: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 2864 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2922

Query: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 2923 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2982

Query: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
            D  K    + +  E   KT+ E  NLL
Sbjct: 2983 DFSKTLTAQSHMYE---KTIAEGENLL 3006



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2833 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2889

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2890 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2949

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 2950 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 3009

Query: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 3010 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 3069

Query: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 3070 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 3129

Query: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 3130 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3189

Query: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 3190 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3249

Query: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 3250 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3304

Query: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 3305 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3361

Query: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
              Q +E Q  G +K +EE   K+
Sbjct: 3362 --QAREEQVEGTIKRLEEFYSKL 3382



 Score = 40.0 bits (92), Expect = 0.035
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4720 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4769

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4770 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4800

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4918

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4919 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4967

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4968 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 5019

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 5020 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 5076

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 5077 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 5132

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 5133 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5187

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5188 TYKRRAAD 5195


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 2291 bits (5938), Expect = 0.0
 Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 382  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 442  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 502  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 562  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 622  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 682  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 742  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 862  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 922  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 982  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461

Query: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521

Query: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
            QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1551



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3515 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3575 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3627

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3682

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3683 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3726

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 3727 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3784

Query: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3785 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3837

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3838 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3887

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3888 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3940

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3997

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 3998 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4057

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4058 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4162

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4219

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4279

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 4280 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4331

Query: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 4332 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4385

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 4386 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4432

Query: 1234 DQTTGEVLSVFQAV 1247
             +T  E L+V   V
Sbjct: 4433 PETAKEQLNVHMEV 4446



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 956  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1014

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 1015 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1074

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 1075 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1134

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 1135 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1184

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 1185 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1240

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 1241 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1296

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 1297 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1355

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 1356 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1412

Query: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 1413 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1472

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 1473 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1532

Query: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 1533 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591

Query: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 1592 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1651

Query: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1652 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1705

Query: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1706 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1764

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1765 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1824

Query: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
            S K+++ + +     ++E+L+K
Sbjct: 1825 SEKKMKLTHS-----LQEELEK 1841



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4254

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4255 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4311

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4312 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4345

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4346 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4461

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4462 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4517 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4562

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4563 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4616

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4617 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4676

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4677 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4735

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4736 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4788

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4789 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 4846 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 4905 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4964

Query: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 4965 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5012



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 110/566 (19%), Positives = 239/566 (42%), Gaps = 52/566 (9%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3221 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3334

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3335 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450

Query: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 3451 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509

Query: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q   ++ + L + + E 
Sbjct: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ--DYSTEGLWKQQSEL 3567

Query: 1107 KSLEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
            + L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T
Sbjct: 3568 RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3627

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
                L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      
Sbjct: 3628 ----LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPK 3677

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            ++K E K +K +  ++++ +  +L +
Sbjct: 3678 ELKKEAKNNKALLDSLNEVSSALLEL 3703



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 1178 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1222

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 1223 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1279

Query: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1339

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 1340 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1399

Query: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 1400 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1451

Query: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 1452 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1488

Query: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 1489 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1529

Query: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 1530 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1589

Query: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1649

Query: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1707

Query: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 1708 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1767

Query: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 1768 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1826

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 1827 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1886

Query: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 1887 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1946

Query: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 1947 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2006

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 2007 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059

Query: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2119

Query: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 2120 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2179

Query: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
            T   V++ E L + +   ++  T  +  V
Sbjct: 2180 TK--VELFENLSEKLQTFLETKTQALTEV 2206



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 3643 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3702

Query: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3762

Query: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 3763 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3822

Query: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3881

Query: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 3882 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3941

Query: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 3942 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 3991

Query: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 3992 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4051

Query: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 4052 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4103

Query: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4161

Query: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4221

Query: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 4222 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281

Query: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341

Query: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 4342 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4392

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 4393 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4449

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 4450 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4483

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 4484 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529

Query: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 4530 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4589

Query: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 4590 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4646



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1851 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1910

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1911 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1970

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 1971 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2027 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2083 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2140

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2141 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2246

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2247 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2361

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2362 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2396

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2397 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2447

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2508 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2565

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625

Query: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2685

Query: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 2686 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2744

Query: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 2745 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2804

Query: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
            D  K    + +  E   KT+ E  NLL
Sbjct: 2805 DFSKTLTAQSHMYE---KTIAEGENLL 2828



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2711

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2712 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 2772 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2831

Query: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 2832 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2891

Query: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 2892 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2951

Query: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 2952 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3011

Query: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 3012 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3071

Query: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 3072 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3126

Query: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 3127 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3183

Query: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
              Q +E Q  G +K +EE   K+
Sbjct: 3184 --QAREEQVEGTIKRLEEFYSKL 3204



 Score = 40.0 bits (92), Expect = 0.035
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4542 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4591

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4592 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4622

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4623 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4740

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4789

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4790 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4841

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4898

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4899 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4954

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4955 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5010 TYKRRAAD 5017


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 2191 bits (5677), Expect = 0.0
 Identities = 1136/1255 (90%), Positives = 1171/1255 (93%), Gaps = 18/1255 (1%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140
            YTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L++++  
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LENSKLT 1137

Query: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQE-SY 1199
            GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +++ S 
Sbjct: 1138 GK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNVEDISL 1184

Query: 1200 NLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDY 1254
              + +ES  +    +    V+ +E  ++ +   + Q T E  +   AV   L+++
Sbjct: 1185 QKIRAESEAKQYRRELETIVREKEAAERELE-RVRQLTIEAEAKRAAVEENLLNF 1238



 Score =  117 bits (294), Expect = 1e-25
 Identities = 298/1493 (19%), Positives = 584/1493 (39%), Gaps = 264/1493 (17%)

Query: 282  VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH-KNVHRAIE----------------- 323
            + +L   V E++ Q  R E   +LP V    EN  +   R +E                 
Sbjct: 1140 ISELERMVAELKKQKSRVE--EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYR 1197

Query: 324  -EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 382
             E E+ ++E + +E ++    +LT   +  R   +   LLN     E +  T        
Sbjct: 1198 RELETIVREKEAAERELERVRQLTIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHL 1256

Query: 383  TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 442
              + + LN+ E+++     ++    + RK+D   EL++ + Q E+++   +++AE+ L E
Sbjct: 1257 KRKDLSLNDLEQQK-----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311

Query: 443  NHPARLTIEAYRAAMQTQWSW---ILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLK 499
                ++ +EA R   + Q++     L +C   +          +  +D ++A +  + + 
Sbjct: 1312 KQ--KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD 1369

Query: 500  D--AIQRKYSCDRSSSIHKLEDLVQE--SMEEKEELLQYKSTIANLMGKAKTIIQLK--- 552
            +  A  RK   D     ++L  L  E  S EEK  LL+ K    N      T+  LK   
Sbjct: 1370 ELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN-----NTLRCLKLEL 1424

Query: 553  PRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC 612
             R        S  ++ +   RQ+  T  K +E  +   S   K K       E++     
Sbjct: 1425 ERKDQAEKGYSQQLREL--GRQLNQTTGKAEE-AMQEASDLKKIKRNYQLELESL----- 1476

Query: 613  FTVPPPNKEAVDLANRIEQQYQNVLTLWH---ESHI-NMKSVVSWHYLINEIDRIRASNV 668
                  N E   L   +++     +T  H   E +I ++ S +       E++R++    
Sbjct: 1477 ------NHEKGKLQREVDR-----ITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525

Query: 669  AS--IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELL 726
             S  +K      H+Q+L N+++      E++ + Q  +     +LEK  N C +  ++ +
Sbjct: 1526 KSDHLKEQFEKSHEQLLQNIKAE----KENNDKIQRLN----EELEKS-NECAEMLKQKV 1576

Query: 727  KSAEREEQEESVYNLYI-SEVRNIRLRLENCEDRL-IRQIRTPLERDDLHESVFRITEQE 784
            +   R+  E  +    I +E  NI L  +  + R    +I+    +D L  +   + +Q 
Sbjct: 1577 EELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQT 1636

Query: 785  KLKKELER----LKDDLGTITNKCEEFFSQA--------AASSSVPTLRSELNV------ 826
            K +++ +R    L++DL    N   EF  +              V  L +ELN       
Sbjct: 1637 KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696

Query: 827  -----VLQNMNQVYSMSS------------TYIDKLKTVNLVL------KNTQAAE---- 859
                 V     QV  +++            T  +++    +VL      K  Q+AE    
Sbjct: 1697 RGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRK 1756

Query: 860  ALVKLYETKLCEEEAVI---------------ADKN------NIENLISTLKQWRSEVDE 898
             + KL E+K+  E  +                A +N      NI+ L   L+Q+R ++ +
Sbjct: 1757 KMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816

Query: 899  KRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLR- 957
             +   H   +  QK + + DE+    +E     +  K+K DQ ++  ++  V +   ++ 
Sbjct: 1817 GQ---HMEANHYQKCQKLEDELIAQKRE----VENLKQKMDQQIKEHEHQLVLLQCEIQK 1869

Query: 958  -----------DLEGIGKSLKY-----YRDTYH-------PLDDWIQQVETTQRKIQENQ 994
                       D E   K  ++      R+T H       PL  W Q+ +  + K Q   
Sbjct: 1870 KSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV 1929

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
             E          + +       +++ K  +C  Y+E +S T  + ++       +    +
Sbjct: 1930 VEQIP------KEVQFQPPGAPLEKEKSQQC--YSEYFSQTSTELQITFDETNPITRLSE 1981

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
               ++ + + +S   +   + D       LV ++T  ++ A +    +  E  +L++EK 
Sbjct: 1982 IEKIRDQALNNSRPPV--RYQD-NACEMELVKVLTP-LEIAKNKQYDMHTEVTTLKQEKN 2037

Query: 1115 EHVEKAKELQKWVSNISKTLK--DAEKAGKPPFSKQKISSEEIST------KKEQLSEAL 1166
              V  A+E        S  LK  D  K G  P + Q    +   +      K + L   +
Sbjct: 2038 P-VPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTV 2096

Query: 1167 QTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLD 1226
               QL  AK  D  T E+     K V+ +Q++ N   +++                    
Sbjct: 2097 TARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATS------------------ 2138

Query: 1227 KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKS 1286
              IAG   ++T E +S   A  R +ID    +  LE Q     +I P   + + ++DA  
Sbjct: 2139 --IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVL 2196

Query: 1287 HGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346
             G++D +   +L E  KA    S +S  T+ V  A+   M+       +LE  +++G ++
Sbjct: 2197 KGVVDPEFRIRLLEAEKAAVGYSYSS-KTLSVFQAMENRMLDRQKGKHILEAQIASGGVI 2255

Query: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406
             P  G ++  + A QQ L+++A+   + E  +  +   +P   + +   ++++       
Sbjct: 2256 DPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVE 2315

Query: 1407 TGMWLLP--------VRPQEGGRITL---KCGRNISILRAAHEGLIDRETMFRLLSAQL- 1454
            +  +L P        +  ++  RI++   K G  +++  A    LI++     L   Q  
Sbjct: 2316 SQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQ 2375

Query: 1455 ------------LSGGLINSNSGQRMTVEEAVREGVIDR--------------DTASSIL 1488
                         S  L ++ +G    + EA+ +G ID+              + A S+L
Sbjct: 2376 WKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLL 2435

Query: 1489 TYQV-------QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
            +  V          G   +   +R++V +A + +L+   +AL  LEAQ    G+I P +G
Sbjct: 2436 SRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTG 2495

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIID 1594
            + +  + +L + L+    A ++      I  +  P +++++ +  A    II+
Sbjct: 2496 KKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIIN 2548



 Score =  112 bits (281), Expect = 4e-24
 Identities = 210/1066 (19%), Positives = 412/1066 (38%), Gaps = 216/1066 (20%)

Query: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739
            ++ L+  Q+   +F +   +  +     I   +KEV   +    EL  S E + + E   
Sbjct: 1650 EEDLAKSQNLVSEFKQKCDQQNII----IQNTKKEV---RNLNAELNASKEEKRRGEQKV 1702

Query: 740  NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGT 799
             L  ++V+ +  RL+  +D             +LH    +  E++   +++   +++ G 
Sbjct: 1703 QLQQAQVQELNNRLKKVQD-------------ELH---LKTIEEQMTHRKMVLFQEESGK 1746

Query: 800  ITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAE 859
                 EEF             R ++  ++++  +V + +     +L  V+L  +N++A E
Sbjct: 1747 FKQSAEEF-------------RKKMEKLMES--KVITENDISGIRLDFVSLQQENSRAQE 1791

Query: 860  ALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 919
                    KLCE         NI+ L   L+Q+R ++ + +   H   +  QK + + DE
Sbjct: 1792 ------NAKLCE--------TNIKELERQLQQYREQMQQGQ---HMEANHYQKCQKLEDE 1834

Query: 920  MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLR------------DLEGIGKSLK 967
            +    +E     +  K+K DQ ++  ++  V +   ++            D E   K  +
Sbjct: 1835 LIAQKRE----VENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQ 1890

Query: 968  YY-----RDTYH-------PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            +      R+T H       PL  W Q+ +  + K Q    E          + +      
Sbjct: 1891 HSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIP------KEVQFQPPGA 1944

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
             +++ K  +C  Y+E +S T  + ++       +    +   ++ + + +S   +   + 
Sbjct: 1945 PLEKEKSQQC--YSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV--RYQ 2000

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
            D       LV ++T  ++ A +    +  E  +L++EK   V  A+E        S  LK
Sbjct: 2001 DNACEME-LVKVLTP-LEIAKNKQYDMHTEVTTLKQEKNP-VPSAEEWMLEGCRASGGLK 2057

Query: 1136 DAE--KAGKPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKHGDKMTDEERNE 1187
              +  K G  P + Q    +   + ++       L   +   QL  AK  D  T E+   
Sbjct: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117

Query: 1188 LEKQVKTLQESYNL----------LFSESLKQLQESQTSGDVKVEEKL------------ 1225
              K V+ +Q++ N           L+ ES K+     ++ +  + +K+            
Sbjct: 2118 GLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177

Query: 1226 ---------------DKVIAGTIDQT-----------------TGEVLSVFQAVLRGLID 1253
                           D V+ G +D                   + + LSVFQA+   ++D
Sbjct: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRMLD 2237

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKA--------- 1304
               G  +LE Q+   G+I P        + A   GL++  IL  L E S           
Sbjct: 2238 RQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNN 2297

Query: 1305 KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTG---SLVIPATGEQLTLQKAFQ 1361
            K+ +  +    + V D  +Q  +       +  + +      S+V   TG +LT+ +AFQ
Sbjct: 2298 KQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357

Query: 1362 QNLVSSALFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTLQENTG 1408
            +NL+  +++ ++  +Q   K+             L D  T    ++ + +++ T+ +   
Sbjct: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL- 2416

Query: 1409 MWLLPVRPQEGGRITLK---------------------------CGRNISILRAAHEGLI 1441
                 V+  + G ITL                             G  IS+L+A+   L+
Sbjct: 2417 -----VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLV 2471

Query: 1442 DRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSN 1501
            DR T  R L AQ+ +GG+I+  +G++  V EA+  G++D   A  +   ++   GI    
Sbjct: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531

Query: 1502 PAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAY 1561
              K ++V EAV  ++I     +  LE Q    GLI P          +LQ  +I   +A 
Sbjct: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591

Query: 1562 KILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLP 1607
            K+ + +  +  +  P++ + +    A +    D +T   L  ++ P
Sbjct: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEP 2637



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 152/889 (17%), Positives = 342/889 (38%), Gaps = 136/889 (15%)

Query: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 630  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688

Query: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 689  RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748

Query: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 749  IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 809  SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 859  EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 914

Query: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 970

Query: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 971  DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1029

Query: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF            
Sbjct: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMD---------- 1076

Query: 820  LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLV-LKNTQ---AAEALVKLYETKLCEEEAV 875
            LR+    ++  M Q    +   + +L+   +   K T    A   L++  +  + E   +
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136

Query: 876  IADKNNIENLISTLKQWRSEVDEKR-QVFHALEDELQKA----------KAISDEMFKTY 924
                + +E +++ LK+ +S V+E+  +V  A E+EL+K           K  ++   K Y
Sbjct: 1137 TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY 1196

Query: 925  KERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE 984
            +         KE A++ +ER + + ++ + +   +E   ++L  +R+        +++  
Sbjct: 1197 RRELETIVREKEAAERELERVRQLTIEAEAKRAAVE---ENLLNFRNQ-------LEENT 1246

Query: 985  TTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTM 1044
             T+R ++++      +L     Q+  L+ E+  K+   +E  K  +Q     KD   Q  
Sbjct: 1247 FTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME---KDLAFQKQ 1303

Query: 1045 TYRAMVDSQQKSPVKRRRMQSSADLIIQEF------MDLRTRYTALVTLMTQYIKFAGDS 1098
                 +  +QK  ++ RR  +      +E       +   T   A+  L  ++ K   + 
Sbjct: 1304 VAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE 1363

Query: 1099 LKR------------------LEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140
            LK+                  L  E  +L+ EK    EKA+ L+  +   + TL+  +  
Sbjct: 1364 LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLE 1423

Query: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELE 1189
             +     +K  S+++     QL++     +  + +  D    +   +LE
Sbjct: 1424 LERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 203/1029 (19%), Positives = 397/1029 (38%), Gaps = 178/1029 (17%)

Query: 302  GSDLPSVESHLENHKNVHRAI------EEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            GSD+  +E  +   K  ++ +      EE E S+    ISE++    ++L       RLE
Sbjct: 705  GSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN---IRL-------RLE 754

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            +   +L+   R      D LH  V R T +     EK ++E+     +  T   + +++ 
Sbjct: 755  NCEDRLIRQIRTPLER-DDLHESVFRITEQ-----EKLKKELERLKDDLGTITNKCEEFF 808

Query: 416  AE---------LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466
            ++         L  EL+   +N+  V  ++   + +     L ++  +AA      +  +
Sbjct: 809  SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 868

Query: 467  LCQ----CVEQHIKEN--TAYFEFFNDAKEATDYLRNLKDAIQR-KYSCDRSSSIHKLED 519
            LC+      +++  EN  +   ++ ++  E       L+D +Q+ K   D     +K  D
Sbjct: 869  LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928

Query: 520  LVQESMEEKEELL---------QYKSTIANLMGKAKT----------------------- 547
            L  +  +EK + L         Q  + + +L G  K+                       
Sbjct: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988

Query: 548  -IIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK--VISPTGN 604
             I + +P NS   L T +  + +    +IE+   K DEC      + A  K   +     
Sbjct: 989  KIQENQPENSKT-LATQLNQQKML-VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY 1046

Query: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
             AMV S   + P   +     A+ I Q++ ++ T +      M   +   +  + + R+ 
Sbjct: 1047 RAMVDSQQKS-PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK--FAGDSLKRLE 1103

Query: 665  ASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE 724
               +   K     EH      LQ +    LE+S+ +       I++LE+ V        E
Sbjct: 1104 EEEIKRCKET--SEHGAYSDLLQRQKATVLENSKLT-----GKISELERMV-------AE 1149

Query: 725  LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRIT-EQ 783
            L K   R E+E  +  +  +    +R +  N ED  +++IR   E       +  I  E+
Sbjct: 1150 LKKQKSRVEEE--LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREK 1207

Query: 784  EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
            E  ++ELER++     +T + E    +AA   ++   R++L        +      T  D
Sbjct: 1208 EAAERELERVRQ----LTIEAEA--KRAAVEENLLNFRNQLE-------ENTFTRRTLED 1254

Query: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 903
             LK  +L L + +  +        KL EE  +   ++N E L+  +KQ   ++  ++QV 
Sbjct: 1255 HLKRKDLSLNDLEQQK-------NKLMEE--LRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305

Query: 904  HALEDELQK----AKAISDEMFKTYKERDLDF-----------------DWHKEKADQL- 941
                 E QK    A+    E+  T +E  L                   +  K+KA++L 
Sbjct: 1306 EKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELK 1365

Query: 942  --VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHP----LDDWIQQVETTQRKIQ---E 992
              V+     + + +  +R+L     +L+  + +       L D + +   T R ++   E
Sbjct: 1366 QQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELE 1425

Query: 993  NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS 1052
             + +  K  + QL +   L  ++     K +E  + A       ++Y+L+  +       
Sbjct: 1426 RKDQAEKGYSQQLRE---LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGK 1482

Query: 1053 QQKSPVKRRRMQSSADLIIQE-------FMDLRTRYTALVT------LMTQYIKFAGDSL 1099
             Q+   +  R  + A+  IQ        F D +      +       L  Q+ K     L
Sbjct: 1483 LQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLL 1542

Query: 1100 KRLEEEEKSLEEEKK--EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1157
            + ++ E+++ ++ ++  E +EK+ E  + +    + L       K    + +  SE I  
Sbjct: 1543 QNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVL 1602

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERN---ELEKQVKTLQESYNLLFSESLKQLQESQ 1214
            +K+ + +  + +++      D   D+ R+    L KQ KT Q+     F   +K L+E  
Sbjct: 1603 EKQTIQQRCEALKI----QADGFKDQLRSTNEHLHKQTKTEQD-----FQRKIKCLEEDL 1653

Query: 1215 TSGDVKVEE 1223
                  V E
Sbjct: 1654 AKSQNLVSE 1662


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 1111 bits (2874), Expect = 0.0
 Identities = 567/1185 (47%), Positives = 825/1185 (69%), Gaps = 82/1185 (6%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLE+L QIAN++Q  ++ CE+KL LA N LQ+D+  LESG   Q E+++  YI ECE L+
Sbjct: 425  RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQ  +D+QIL D  YYQ ++L  RV +L+DE++ LR EC              T L   G
Sbjct: 485  RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
               SL     + + PS  +      T  L +  +T    S  TS                
Sbjct: 531  HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
                                   RKP+ ++ L+  + +E+E N++FV +LL+WV+EMQ++
Sbjct: 564  ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            L+R EWG+DLPSVE  LE  +++H ++EE  SS+KEA++ E +M+     +YAE L +LE
Sbjct: 603  LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            +QY KL  TS  + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y 
Sbjct: 663  TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            +EL  EL++K++  +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q  W+ QLC CVEQH+
Sbjct: 723  SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYF+FF+DA+E   +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K
Sbjct: 783  KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            S++A+L+G++KTI+QLKPR+ D  LK +I +KA+CDYRQIEITI K+DECVL +NS R K
Sbjct: 843  SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y
Sbjct: 903  WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            L  ++D ++  N+  +++  PGE  Q++ NLQ+ +EDFL+DS++S +FS +D  +LE+EV
Sbjct: 963  LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR----TPLERD 771
              CK  +Q L+KS E E++EE+V  +YISE++NIRLRLE  E R++++I+    +  +RD
Sbjct: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082

Query: 772  DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
               ++  RI EQE  +++L++L+ DL  ++ KC+ F  Q+ +SSSVPTLRSELN++++ M
Sbjct: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142

Query: 832  NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
            + VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E   STL+ 
Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202

Query: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
            W S+V +K  VF  L++E+ KAK ++++M +   ER+LD + ++EK  QL ERW  V  Q
Sbjct: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262

Query: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
            ++ R  +LE I + L  YR  +  L  WI++    Q  ++  Q E+S+ L+ QL+QQ  L
Sbjct: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322

Query: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
             +EIE  Q+K+D+CQK+++QYS  VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I 
Sbjct: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382

Query: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1131
            QEFMDLRTRYTALVTL TQ++K+  D+L+RLEEEEK +EEEK+EHVEK KEL  WVS ++
Sbjct: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442

Query: 1132 KTLK------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1179
            +  +            D EKA      +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K
Sbjct: 1443 RNTQGKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHK 1498

Query: 1180 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1224
            ++++E+ ++ +Q+  L ++Y+ L   S  QLQ+ Q+    + E+K
Sbjct: 1499 LSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK 1543



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 171/956 (17%), Positives = 380/956 (39%), Gaps = 157/956 (16%)

Query: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
            E   R+E  Y K++  +   + H++T         + + W   +++ ++   W+      
Sbjct: 931  EMASRVEQSYQKVM--ALWHQLHVNT--------KSLISWNYLRKDLDLVQTWNLEKLRS 980

Query: 409  ARKKDYHAELMRELDQKEENIKS------VQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462
            +   + H ++M+ L    E+         +  +A++L LE       +EA +A  Q    
Sbjct: 981  SAPGECH-QIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEE-----VEACKARFQ---- 1030

Query: 463  WILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LED- 519
                L + +E   KE T    + ++ K     L   +  + ++     SS   +   +D 
Sbjct: 1031 ---HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087

Query: 520  --LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP------------------ 559
               + E    +E+L Q +S +  +  K  + +   P +S  P                  
Sbjct: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147

Query: 560  --------LKT-SIPIKAICDYRQI----EITIYKDDECVLANNSHRAKWKVI----SPT 602
                    LKT  + +++I D   +    EI + +++  +   ++  A W  +    S  
Sbjct: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207

Query: 603  GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662
             ++  V SV        K   +  +R+  +    L  + E    ++    WH +I +++ 
Sbjct: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQE--RWHRVIAQLE- 1264

Query: 663  IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYY 722
            IR S + SI+ +L G+++     L    E+     +  +     D   L ++++     +
Sbjct: 1265 IRQSELESIQEVL-GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF 1323

Query: 723  QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITE 782
             E+ ++  + +Q +     Y + V++  L+L   +  +  Q ++P +R  +  S   IT+
Sbjct: 1324 AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQ 1383

Query: 783  QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842
            +     +L      L T+T +  ++ S A     +  L  E  VV +   +       ++
Sbjct: 1384 EFM---DLRTRYTALVTLTTQHVKYISDA-----LRRLEEEEKVVEEEKQE-------HV 1428

Query: 843  DKLKT----VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE 898
            +K+K     V+ + +NTQ      +  E+   + E  I ++  +   ++T K+  SE  +
Sbjct: 1429 EKVKELLGWVSTLARNTQGKATSSETKEST--DIEKAILEQQVLSEELTTKKEQVSEAIK 1486

Query: 899  KRQVF---HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
              Q+F   H  +   ++ K IS+++    K        + +  D    + Q +  Q+ ++
Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKA-------YHDLCDGSANQLQQLQSQLAHQ 1539

Query: 956  LRDLEGIGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
                    K+L+  ++T H  L+D    V   +R +  +Q   ++   + L + +  + +
Sbjct: 1540 TEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD 1594

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
            ++      D+ Q  A  ++  VKD E      +  +  ++ + ++ +  Q+       E 
Sbjct: 1595 LQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EA 1645

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT- 1133
            +   TR      +  + ++ A  S  + E E+    +E  E+ +K   L  WV+++  + 
Sbjct: 1646 LQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699

Query: 1134 ------LKDAEKAGKPPFSK-------------------------QKISSEEISTKKEQL 1162
                  L   E+       K                          K   +E+ ++++  
Sbjct: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 1759

Query: 1163 SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1218
              A Q+ Q FL +HG  +T EE+  L++++  L+E Y+   ++S  +L++ QT  D
Sbjct: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 193/1020 (18%), Positives = 396/1020 (38%), Gaps = 147/1020 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT------------EWGSDLPSVESH 311
            K++LLDQ L+   +  +   ++LNW+ E++ +L               +    L   E  
Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            +   KNV +AI+  ++ LK+    E+       L   EKL  ++++YA +  TS    R 
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 3598

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            L+      ++  +T E +  WL E EEE   +   S     I + +    EL +E+ +  
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658

Query: 427  ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471
              + +V E++  LL L    AR  ++   +    Q+  +              +Q  Q  
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718

Query: 472  EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
            EQ      A+         A   +R  +D    +    ++ SI    D+++   +  +EL
Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 3773

Query: 532  LQYKSTIANLMGKA-KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590
              ++S I    G+  KT++Q K   ++  ++    I  +   R   +     +   +  N
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 3825

Query: 591  SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650
                 ++ +SP   E    ++   +P P   A+D   ++ QQ + +  L        +S+
Sbjct: 3826 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 3872

Query: 651  VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
                  I+++ +I       +K + P E + V    Q     +                Q
Sbjct: 3873 AEHKPHIDKLLKIGPQ----LKELNPEEGEMVEEKYQKAENMY---------------AQ 3913

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
            +++EV       Q  L   E   Q   +   +  ++  +   LEN   RL      P E 
Sbjct: 3914 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 3966

Query: 771  DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827
            D + E    I++ +    ELE+L+     +  + EE   ++  +    +   ++ +L+ +
Sbjct: 3967 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023

Query: 828  LQNMNQVYSMSST----YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
            +     + + +      ++D L+       +  A    +K  +  + + E+   D + I+
Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4083

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
              +   +  + E D        L +EL+  + +  ++     E +      ++  D++  
Sbjct: 4084 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEKPEV--RKSIDEMNN 4134

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001
             W+N++     RL  LE   ++   Y+DT   + DW+   + T  K+    P  +   T+
Sbjct: 4135 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4191

Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055
              QLN+ K    E+  +Q +M++     E         T +D   + +T  + + ++  +
Sbjct: 4192 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4251

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-KK 1114
                R+     A L + +F        + +T   + +    D+ + +  + K +E E  K
Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL----DAQRPISGDPKVIEVELAK 4307

Query: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
             HV K   L         T++   KAG      +  + ++ S+ + +L    Q  +  L 
Sbjct: 4308 HHVLKNDVLAH-----QATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQ 4360

Query: 1175 KHGDKMTDEERNELEKQVKTLQ------ESYNLLFSESLKQLQESQTSGDV--KVEEKLD 1226
            K     T+E   +L+  ++  Q      E + L  +    QL  S+ +G +     E+LD
Sbjct: 4361 K-----TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4415



 Score = 65.5 bits (158), Expect = 8e-10
 Identities = 191/1028 (18%), Positives = 389/1028 (37%), Gaps = 155/1028 (15%)

Query: 248  NSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG- 302
            N LQ L+     +   K+    QN   +++     +DL +WV + +  L     RT    
Sbjct: 1527 NQLQQLQSQLAHQTEQKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQD 1581

Query: 303  --------SDLPSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKL 351
                    SDL  ++  ++N   +    +++ E  ++E   K+S  ++TA       EKL
Sbjct: 1582 LSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKL 1636

Query: 352  HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411
            H+ + QY  L   +R  ++ L+     V+ A  +     E E+ + A + +E    I   
Sbjct: 1637 HQAKEQYEALQEETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDAL 1688

Query: 412  KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471
             D+   +     Q   N+  +++++   L +   A  T + Y    Q       Q C+ +
Sbjct: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMM 1745

Query: 472  EQHIKENTAYFEFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIH 515
            +   +E  +  + F                N   E    L+     ++ +YS   + S  
Sbjct: 1746 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 1805

Query: 516  KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI 575
            +L+  VQ   +E ++ LQ      + + +++  ++   +    P      +K    + + 
Sbjct: 1806 ELKQ-VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 1864

Query: 576  EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQN 635
             I             SH+   + ++ +G + +     F      KE  ++ N ++ + ++
Sbjct: 1865 VI-------------SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKD 1908

Query: 636  V---LTLWHE------SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------P 676
                 T  H       SH+NM  +  +H   N  D ++A   +  A+++ +L       P
Sbjct: 1909 ATERYTALHSKCTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDP 1967

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------ 728
            G  Q+ L+  +   E+  E     +       DI ++E E     ++ QE   S      
Sbjct: 1968 GVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQ 2027

Query: 729  ------AEREE-------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
                  AER         Q +SV     S +++I    +N E + +  + + + ++ L  
Sbjct: 2028 SLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALAT 2087

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            ++       KLK+++ R K  L   T +    F + A S++   L+ +L  V Q   Q+ 
Sbjct: 2088 NM-------KLKQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLC 2139

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQ 891
                   +K  ++  +L   +  E L    +  +  +  ++A  N    +I +    +++
Sbjct: 2140 LQQQ---EKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE 2196

Query: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
               E++++++    LE  + +  +             LD   H+++   L + +  +   
Sbjct: 2197 LNLEMEDQQENLDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKT 2247

Query: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLAT 1003
            +  R +D     + L  +R        W+++ E        +   K  E Q E+ K+L  
Sbjct: 2248 VKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRM 1063
                +  LV EI  K + ++           T  D + +T +    V S   S V     
Sbjct: 2308 DWASKGTLVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHT 2361

Query: 1064 QSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVE 1118
                  I  +  D+  +Y  L  ++ +  +     L R+EE  K         E KE V 
Sbjct: 2362 CKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2421

Query: 1119 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1178
            K+ +     +  ++T+K   ++ K   ++ + +S +I   KE L+  L T          
Sbjct: 2422 KSMDAMSSPTK-TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2480

Query: 1179 KMTDEERN 1186
            K   EE N
Sbjct: 2481 KKIQEELN 2488



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 196/1100 (17%), Positives = 415/1100 (37%), Gaps = 211/1100 (19%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 305
            +SSLL + + + +   + ++ LL  + E++  L+  +  S                  D+
Sbjct: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095

Query: 306  PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 360
               +S LE   + V R +E  +S+   + + K++E+ Q    L L   EK    ES   K
Sbjct: 2096 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2151

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LL  +   E     L  F+   +  L   N+ +++   +    +  N+            
Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2199

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            E++ ++EN+ +++ +  +L                   +   + L LCQ  ++       
Sbjct: 2200 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2233

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
                 N  K+ T+  + +K+  +   SC ++     KL    Q+ ++E E  +    T  
Sbjct: 2234 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2290

Query: 540  NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 599
            +     K I  LK    D   K ++  +  C    +E  I +    + A +S      ++
Sbjct: 2291 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2346

Query: 600  SPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW----HY 655
               G+     +   T     +   D+++ +  +Y+ +  + HE   +++++++     H 
Sbjct: 2347 PSVGSSVGSVNGYHTCKDLTEIQCDMSD-VNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405

Query: 656  LINEIDRIRASNVASIKTM----LPGEHQQVLSNLQSRFEDFLEDSQES-------QVFS 704
              N + +   S    +K+M     P + + V +  +S      E  Q S       +  +
Sbjct: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465

Query: 705  GSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRLE 754
            G  +T    +     +  QE L S          A + + EES  +L   +    +LR  
Sbjct: 2466 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 2525

Query: 755  NCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEEF 807
              E  L+  +  PL  D         +  F + E E  +++ E+L +   G +T   +  
Sbjct: 2526 LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVS 2585

Query: 808  FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYET 867
             S +     + ++  +   +   +N      S+ ID+      ++K+TQ  E L      
Sbjct: 2586 LSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL-----Q 2631

Query: 868  KLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 923
             L E+   +  + ++++ IST    +KQ   E  E R     L+ E+++A+ + DE+   
Sbjct: 2632 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 2691

Query: 924  YKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ-- 981
              E+ L  D  K++ + +    Q +     +R+  L+    S + ++  +  L  W+   
Sbjct: 2692 IGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750

Query: 982  ------------QVETTQRKIQENQP-----------------------------ENSKT 1000
                        ++E  Q ++QEN+                              E  +T
Sbjct: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810

Query: 1001 LATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKD------------------ 1038
            L  QL + K    E+  K    QS++ +C + A++Y   V+D                  
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870

Query: 1039 -----YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093
                  E   +  +AM++  +K       + S+AD++I                + Q + 
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930

Query: 1094 FAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1153
               + L+      + + +  +E  E  K ++K V      L+  +  G    S + +  E
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL--E 2988

Query: 1154 EISTKKEQLSEALQTIQLFLAKHGDKMTDE-----ERNELEKQVKTLQESYNLLFSESLK 1208
            ++  ++E L +AL+    +L      + ++     + ++L  Q +  Q+ +         
Sbjct: 2989 KLRAQQEVL-QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF--------L 3039

Query: 1209 QLQESQTSGDVKVEEKLDKV 1228
            ++++   SG V +E KL+ +
Sbjct: 3040 EVKQRVNSGCVMMENKLEGI 3059



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1075 (18%), Positives = 403/1075 (37%), Gaps = 199/1075 (18%)

Query: 282  VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
            +Q + +W+D   ++L      G+DL +V+  L   K     +E ++  ++  K++     
Sbjct: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4221

Query: 341  APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
               K T             E  H  E+   K+ +     E  L  L  F       + WL
Sbjct: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281

Query: 390  NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
               EE       ++ D       +A+    H  L  ++   +  +++V +   +LL  + 
Sbjct: 4282 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4337

Query: 445  -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
                 ++ +   AM   W  +LQ  +  EQ ++      + F+   E  D+L  L    +
Sbjct: 4338 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4392

Query: 504  RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
             +     S     L +  +E ++   EL       + T   L+ K + ++ L   +S   
Sbjct: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4451

Query: 560  LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
             KT   +  +                         KW V+S    E              
Sbjct: 4452 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4479

Query: 620  KEAVDLANRIE---QQYQNVLTLWHESHINMKSVVSW--HYLINEIDR-------IRASN 667
            +EA++LA   +   Q++ N LTL  +S +N+ S  S   + ++++I+        + A  
Sbjct: 4480 EEALNLATEFQNSLQEFINWLTLAEQS-LNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538

Query: 668  VASIKTMLPGEHQQVLS-------------NLQSRFEDFLEDSQESQVFSGSDITQLEKE 714
               I+    G   + LS             ++QSR+E  ++ S E     G  +    K 
Sbjct: 4539 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKR 4594

Query: 715  VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE----- 769
                KQ+++   K  +  E  ES  +          L + N  D++  Q+    E     
Sbjct: 4595 A---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTL 4643

Query: 770  --RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 823
              +  ++++  R    + E+  L ++ ++L + LG + +K +    ++            
Sbjct: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ-------- 4695

Query: 824  LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
                   + +    S  ++D L+ +          + L K+ E +L E++ V  D + + 
Sbjct: 4696 -----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVM 4740

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
            NL+   K ++ E+ ++      L       K    E+ +  ++   D  W K +  +L  
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELST 4790

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLAT 1003
            RW  V     ++   LE   K  + +RDT H L +W+ + E T R  +   P++++ L +
Sbjct: 4791 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQS 4849

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------ 1052
             ++  K  + ++E K+  ++      E   A      + T+ +     RA  +       
Sbjct: 4850 LIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAK 4909

Query: 1053 --QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1110
              QQ+       + ++A+L+ +    ++   T L+    + I    D +K L  E ++  
Sbjct: 4910 QHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFM 4969

Query: 1111 EE---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIS 1156
            EE   K+  V++  +  K   NI  T    ++ +   G+       PP       SE  +
Sbjct: 4970 EEMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5028

Query: 1157 TKKEQLSEALQTIQLFLAKHGDKMTD-----EERNEL---------EKQVKTLQESYNLL 1202
             +  QLS   Q + L   +   K+ D     EE  E          +K ++ +    + +
Sbjct: 5029 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRV 5088

Query: 1203 FSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGE---VLSVFQAVLRGLIDY 1254
              +  +++ + Q  G +  +E +D ++A     T  E   V  +F     G IDY
Sbjct: 5089 M-DFFRRIDKDQ-DGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY 5141



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 192/1080 (17%), Positives = 404/1080 (37%), Gaps = 202/1080 (18%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLP-SVESHLENHKNVHRAI 322
            +SS +DQ + +     + +QDL   V  +  +L      S  P +V+  LE    +   +
Sbjct: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671

Query: 323  EEFESSLKEAK---------ISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQER 370
            E+ +  +KEA+         I E  +   LK    T A  L  LE   A  +N     + 
Sbjct: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN---RLQA 2728

Query: 371  HLDTLHNFVSRATNELIWLNEKEEEEVAY-DWSERNTNIARKKDYHAELMRELDQKEENI 429
             L +   F         WL++K+ ++      S +   +  +   + E  + L+Q   + 
Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788

Query: 430  KSVQEIAEQLLLENHPA--RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
            + +    E LLL   P   + T++     ++  W  +                       
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL----------------------- 2825

Query: 488  AKEATDYLRNLKDAIQR--KYSCDRSSSIHKLEDLVQESME--------EKEELLQYKST 537
            +K+  D    LKD +Q+  KY       +  +ED   +  E        + E  L     
Sbjct: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 2885

Query: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
            + N + K ++++++    +D  + +S          + +    +D++  +  N      +
Sbjct: 2886 MLNEVEKRRSLLEILNSAADILINSS----------EADEDGIRDEKAGINQNMDAVTEE 2935

Query: 598  VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
            + + TG+               +E        ++ ++N+           K V    + +
Sbjct: 2936 LQAKTGSL--------------EEMTQRLREFQESFKNI----------EKKVEGAKHQL 2971

Query: 658  NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS---GSDITQLEKE 714
               D + +   ++         Q+VL  L+ +  D+L +  +  V     GSD +QL  +
Sbjct: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQGLVEDAPDGSDASQLLHQ 3030

Query: 715  VNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNIRLRLENCEDRL--------- 760
              V +Q + E+ +         E + E +   +   VR +  +L + +D L         
Sbjct: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC-RVREMFSQLADLDDELDGMGAIGRD 3089

Query: 761  -------IRQIRTPLERD-------DLHESVFRITEQEKLKKELERLKDDLGTITNKCEE 806
                   I  +R  L +        +  E+  R   +E+   +L  LK +L  +  +C +
Sbjct: 3090 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149

Query: 807  FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
               +  A       + +L + L  +   Y        KLK +N      + AEAL  +  
Sbjct: 3150 LTERGKAR------QEQLELTLGRVEDFYR-------KLKGLNDATTAAEEAEALQWVVG 3196

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE 926
            T++      +AD                ++ +K QV   L+ +LQ+   +   + ++   
Sbjct: 3197 TEVEIINQQLAD---------------FKMFQKEQV-DPLQMKLQQVNGLGQGLIQS-AG 3239

Query: 927  RDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
            +D D    +   +++  RW  ++ ++  R+  L+        ++D   PL  W+     T
Sbjct: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD---T 3296

Query: 987  QRKIQENQPENS--KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQ 1042
            +  I   +P ++  K +  Q+ +QK+L   ++ +++ +D  Q    +   SA + D E  
Sbjct: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356

Query: 1043 TMTYRAM----VDSQQKSPVKRRRMQSSADLIIQ--EFMDLRTRYTALVTLMTQYIKFAG 1096
            T    ++     +   K+  ++++++    L  Q  E  +  + + ++        +  G
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416

Query: 1097 DSLKRLEEE---EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152
                +++++    K+LEE+ + H     +  K   ++S     AE+        +KI S 
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG----VLSEKIDSL 3472

Query: 1153 --------EEISTKKEQLSEALQTIQLF----------LAKHGDKMTDEERNELEKQVKT 1194
                    +    K   L +AL   +LF          LA+  DK++     + ++ V  
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 3532

Query: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVI---AGTIDQTTGEVLSVFQAVLRGL 1251
             Q + +L  +E +           V  ++ +D+ I      + QTTGE + + Q  L G+
Sbjct: 3533 RQHADHLALNEEI-----------VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 178/991 (17%), Positives = 377/991 (38%), Gaps = 185/991 (18%)

Query: 429  IKSVQEIAEQLLLENHPARLTIE----AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEF 484
            ++S+Q+   +LL++ +  +L+ E    A  +A++  WS +                   +
Sbjct: 1163 VRSIQDA--ELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH-----------------W 1203

Query: 485  FNDAKEATDYLRNLKDAIQR-KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMG 543
             +D K+       L + I + K   ++ S +    +L  E  +EK   LQ +        
Sbjct: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWH------ 1257

Query: 544  KAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPT- 602
              + I QL+ R S+      +    + DYR    T+ K  E   A        +      
Sbjct: 1258 --RVIAQLEIRQSELESIQEV----LGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRV 1311

Query: 603  -GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
               +    +  F     N+  +D   +  QQY  ++  +    +  K+ V          
Sbjct: 1312 LSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE--------- 1362

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY 721
                      +   PG+ +++LS+  +  ++F+ D +       +  TQ  K ++   + 
Sbjct: 1363 ---------SQQKSPGKRRRMLSSSDAITQEFM-DLRTRYTALVTLTTQHVKYISDALRR 1412

Query: 722  YQELLKSAEREEQE--ESVYNL--YISEV-RNIRLRLENCEDRLIRQIRTPLERDDLHES 776
             +E  K  E E+QE  E V  L  ++S + RN + +  + E +         E  D+ ++
Sbjct: 1413 LEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETK---------ESTDIEKA 1463

Query: 777  VFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY- 835
            +    EQ+ L +EL   K+ +       + F ++     S    + +++  L  +N+ Y 
Sbjct: 1464 IL---EQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKE-KKQISEQLNALNKAYH 1519

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS-----TLK 890
             +     ++L+ +   L +    + L K   T   + E + +     E  ++     T +
Sbjct: 1520 DLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ 1579

Query: 891  QWRSEVDEKRQVFHALEDELQK-----AKAISD-EMFKTYKERDL---DFDWHKEKADQL 941
            Q  S + + +     L+D++Q      A  + D E F    +  L   +    +EK  Q 
Sbjct: 1580 QDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 1639

Query: 942  VERWQNVHVQIDNRLRDLEGI--------------GKSLKYYRDTYHPLDDWIQQVETTQ 987
             E+++ +  +     ++LE                 K L   +     L DW+  V ++ 
Sbjct: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699

Query: 988  RKIQENQPENSKTLATQLNQQKMLVSE----IEMKQSKMD-ECQKYAEQYSATV---KDY 1039
             ++  N P   +     L +  +  ++    +     K+D +C+    ++   +   +++
Sbjct: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 1759

Query: 1040 ELQTMTYRAMVDSQ--QKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD 1097
             L T + +A +D      +P +++ +Q       Q+  +L+ +Y+  +      +K    
Sbjct: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK---- 1808

Query: 1098 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPP------FSKQKIS 1151
                   + ++L++E ++ ++  KE + W+    K L++  K G  P        +Q   
Sbjct: 1809 -------QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF 1861

Query: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER------------NELEKQVKTLQESY 1199
            SE++ + K  L         F+   G K+ D E             N ++ ++K   E Y
Sbjct: 1862 SEDVISHKGDLR--------FVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 1913

Query: 1200 NLLFSES----------LKQLQESQTSGD------VKVEEKLDKVIAGTIDQTTG---EV 1240
              L S+           L Q  + Q S D         E  ++K+++ T+    G   E 
Sbjct: 1914 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 1973

Query: 1241 LSVFQAVLRGLIDYDTGIRLLETQ----LMISGLISPELRKCFDLKDA-KSHGLIDEQIL 1295
            L+  + +   L ++   +  L+      + I G  +P+ R   +  D+  SH    + + 
Sbjct: 1974 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH---FQSLS 2030

Query: 1296 CQLKELSKAKEIISAASPTTIPVLDALAQSM 1326
              L E S   +   A S +    L++L QS+
Sbjct: 2031 YSLAERSSLLQKAIAQSQSVQESLESLLQSI 2061



 Score = 39.3 bits (90), Expect = 0.060
 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
            K S L+Q L + E+    V  LL W+ E +  L  R     D  +++S ++ HK   + +
Sbjct: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861

Query: 323  EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
            EE    +  A  + E+ +         T    +  + +++ ++L  ++  ++ L+T L  
Sbjct: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921

Query: 378  FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
             V+ A      L W+   E   +  D      NI R K     H   M E+ +K+ ++  
Sbjct: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 4981

Query: 432  VQEIAEQLLLE 442
            V +  ++  +E
Sbjct: 4982 VTKTYKRKNIE 4992



 Score = 37.7 bits (86), Expect = 0.18
 Identities = 99/503 (19%), Positives = 204/503 (40%), Gaps = 69/503 (13%)

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
            T+  K+++++ R K     I N   +         S+ +L S  E  V+ + ++ + +  
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3476

Query: 839  STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
            S   D+      +L    +   L    E ++    A + DK     L S  +K ++ +V 
Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 3531

Query: 898  EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
             ++   H AL +E+   K   D+  K        T  E  L     +EK D +  R+ ++
Sbjct: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 3588

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE----------TTQRKIQENQPENS 998
             V     LR LE   +    ++ TY  L  W+++VE           T  +I + Q +  
Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ-QRQ 3647

Query: 999  KTLATQLNQQKMLVSEI-EMKQSKMDECQKYAEQ-----YSATVKDYELQTMTYRAMVDS 1052
            K L  ++ + ++++  + E+ ++ ++     A +      S   + Y+L + T    VD 
Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707

Query: 1053 QQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---------VTLMTQYIK-FAGDSLKRL 1102
               +  + ++ + +AD  +    + + +  AL          T   Q  K F+ D ++  
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 3767

Query: 1103 EEEEKSL-----------EEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1151
            +  ++             EE+K    EK + L +    IS  L ++E+  +    + ++ 
Sbjct: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS--LLNSERYAR--LERAQVL 3823

Query: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER-NELEKQVKTLQES---YNLLFSESL 1207
              +     E+LS  ++  +  +A+      D E+  + +++++ L+ES   +     + L
Sbjct: 3824 VNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 3883

Query: 1208 K---QLQESQTSGDVKVEEKLDK 1227
            K   QL+E        VEEK  K
Sbjct: 3884 KIGPQLKELNPEEGEMVEEKYQK 3906



 Score = 36.2 bits (82), Expect = 0.51
 Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)

Query: 279  MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
            M  +Q L++W+ +++ QL  D+   G DL  V + ++ HK   + + +   +++  K S 
Sbjct: 4709 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 4767

Query: 336  -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
             E+   +    T+ + +L  L +++  +   S +++  L+       V R T  ++  WL
Sbjct: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827

Query: 390  NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
            +E E+          +T   +   D H E M+++++K  ++ S   + E +L   HP  +
Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887

Query: 449  T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
            T     I   RA  +   +W  Q  Q +E  + E  A  E   +
Sbjct: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 4931


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1454



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3661 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3719

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3720 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3777

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3778 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3837

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3838 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3894

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3895 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3954

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3955 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4014

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4015 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4074

Query: 1596 NTASIL 1601
                IL
Sbjct: 4075 EMNEIL 4080



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2521 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2626

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2627 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2685

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2686 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2745

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2746 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2803

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2804 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2863

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2864 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2923

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2924 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2983

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2984 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3043

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3044 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3103

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3104 GYRDPYTGQSVSLFQALKKGLI 3125



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1971

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1972 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2029

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2030 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2265 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2317 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2373 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2403

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2519

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2576

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2577 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2620

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2674

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2675 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2723

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2724 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2764

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2885 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2939

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2940 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2999

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 3000 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3059

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3060 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3119

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3120 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3171



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3765 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3824

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3825 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3883

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3884 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3943

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3944 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4003

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 4004 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4063

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4064 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4122

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4123 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4167



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 4008 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4067

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4068 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4118 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4165

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4166 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4225

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4226 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4285

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4286 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4345

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4346 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4405

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4406 VPLDEALQRGTVDARTAQKLRDV 4428



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3099 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3158

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3159 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3218

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3219 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3276

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3277 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3333

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3334 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3393

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3394 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3453

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3454 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3511

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3512 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3567



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3322 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3381

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3382 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3439

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3440 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3499

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3500 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3559

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3560 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3619

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3620 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3679

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3680 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3739

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3740 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3796



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4037

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4038 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4095

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4096 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4155

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4156 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4215

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4216 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4275

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4276 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4335

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4336 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4395

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4396 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4455

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4456 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4492



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3025 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3084

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3085 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3142

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3143 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3202

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3203 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3246

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3247 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3292

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3293 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3352

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3353 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3388



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1556 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1727

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1783

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2024 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2071

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2130 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2249 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2308 AEKMLKEK 2315


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 522  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 642  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 702  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 762  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1300

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1417

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1418 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1458



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3665 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3723

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3724 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3781

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3782 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3841

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3842 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3898

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3899 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3958

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3959 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4018

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4019 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4078

Query: 1596 NTASIL 1601
                IL
Sbjct: 4079 EMNEIL 4084



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2288 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2525 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2630

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2631 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2689

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2690 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2749

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2750 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2807

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2808 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2867

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2868 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2927

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2928 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2987

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2988 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3047

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3048 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3107

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3108 GYRDPYTGQSVSLFQALKKGLI 3129



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1975

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1976 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2033

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2034 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2269 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2321 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2377 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2407

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2523

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2580

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2581 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2624

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2625 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2678

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2679 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2727

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2728 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2768

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2769 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2828

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2829 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2888

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2889 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2943

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2944 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 3003

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 3004 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3063

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3064 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3123

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3124 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3175



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3769 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3828

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3829 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3887

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3888 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3947

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3948 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4007

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 4008 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4067

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4068 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4126

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4127 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4171



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 4012 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4071

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4072 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4121

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4122 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4169

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4170 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4229

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4230 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4289

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4290 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4349

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4350 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4409

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4410 VPLDEALQRGTVDARTAQKLRDV 4432



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3103 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3162

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3163 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3222

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3223 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3280

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3281 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3337

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3338 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3397

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3398 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3457

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3458 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3515

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3516 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3571



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3326 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3385

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3386 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3443

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3444 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3503

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3504 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3563

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3564 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3623

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3624 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3683

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3684 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3743

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3744 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3800



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3984 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4041

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4042 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4099

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4100 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4159

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4160 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4219

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4220 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4279

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4280 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4339

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4340 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4399

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4400 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4459

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4460 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4496



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3029 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3088

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3089 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3146

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3147 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3206

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3207 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3250

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3251 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3296

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3297 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3356

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3357 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3392



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 394 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 453

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 454 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 491



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1560 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1731

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1787

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2028 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2075

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2133

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2134 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2253 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2312 AEKMLKEK 2319


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1454



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3661 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3719

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3720 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3777

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3778 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3837

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3838 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3894

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3895 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3954

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3955 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4014

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4015 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4074

Query: 1596 NTASIL 1601
                IL
Sbjct: 4075 EMNEIL 4080



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2521 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2626

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2627 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2685

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2686 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2745

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2746 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2803

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2804 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2863

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2864 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2923

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2924 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2983

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2984 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3043

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3044 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3103

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3104 GYRDPYTGQSVSLFQALKKGLI 3125



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1971

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1972 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2029

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2030 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2265 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2317 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2373 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2403

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2519

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2576

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2577 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2620

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2674

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2675 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2723

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2724 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2764

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2885 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2939

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2940 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2999

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 3000 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3059

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3060 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3119

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3120 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3171



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3765 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3824

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3825 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3883

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3884 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3943

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3944 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4003

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 4004 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4063

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4064 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4122

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4123 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4167



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 4008 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4067

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4068 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4118 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4165

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4166 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4225

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4226 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4285

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4286 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4345

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4346 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4405

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4406 VPLDEALQRGTVDARTAQKLRDV 4428



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3099 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3158

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3159 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3218

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3219 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3276

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3277 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3333

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3334 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3393

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3394 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3453

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3454 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3511

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3512 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3567



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3322 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3381

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3382 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3439

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3440 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3499

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3500 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3559

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3560 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3619

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3620 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3679

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3680 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3739

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3740 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3796



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4037

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4038 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4095

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4096 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4155

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4156 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4215

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4216 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4275

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4276 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4335

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4336 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4395

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4396 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4455

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4456 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4492



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3025 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3084

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3085 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3142

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3143 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3202

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3203 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3246

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3247 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3292

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3293 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3352

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3353 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3388



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1556 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1727

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1783

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2024 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2071

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2130 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2249 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2308 AEKMLKEK 2315


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 486  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 606  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 666  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 726  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 966  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1264

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1381

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1382 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1422



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3629 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3687

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3688 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3745

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3746 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3805

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3806 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3862

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3863 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3922

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3923 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 3982

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 3983 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4042

Query: 1596 NTASIL 1601
                IL
Sbjct: 4043 EMNEIL 4048



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2252 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2489 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2594

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2595 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2653

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2654 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2713

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2714 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2771

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2772 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2831

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2832 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2891

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2892 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2951

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2952 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3011

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3012 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3071

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3072 GYRDPYTGQSVSLFQALKKGLI 3093



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1939

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1940 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 1997

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 1998 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2233 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2285 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2341 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2371

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2487

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2544

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2545 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2588

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2589 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2642

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2643 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2691

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2692 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2732

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2733 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2792

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2793 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2852

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2853 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2907

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2908 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2967

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 2968 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3027

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3028 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3087

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3088 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3139



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3733 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3792

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3793 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3851

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3852 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3911

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3912 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 3971

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 3972 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4031

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4032 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4090

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4091 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4135



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 3976 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4035

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4036 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4085

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4086 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4133

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4134 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4193

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4194 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4253

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4254 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4313

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4314 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4373

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4374 VPLDEALQRGTVDARTAQKLRDV 4396



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3067 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3126

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3127 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3186

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3187 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3244

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3245 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3301

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3302 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3361

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3362 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3421

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3422 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3479

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3480 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3535



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3290 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3349

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3350 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3407

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3408 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3467

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3468 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3527

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3528 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3587

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3588 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3647

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3648 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3707

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3708 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3764



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3948 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4005

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4006 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4063

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4064 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4123

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4124 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4183

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4184 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4243

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4244 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4303

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4304 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4363

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4364 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4423

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4424 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4460



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 2993 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3052

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3053 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3110

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3111 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3170

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3171 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3214

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3215 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3260

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3261 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3320

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3321 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3356



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 358 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 417

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 418 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 455



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1524 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1695

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1751

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 1992 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2039

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2097

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2098 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2217 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2276 AEKMLKEK 2283


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 655  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 715  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 775  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 835  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 895  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 955  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1591



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3798 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3856

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3857 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3914

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3915 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3974

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3975 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 4031

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 4032 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 4091

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 4092 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4151

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4152 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4211

Query: 1596 NTASIL 1601
                IL
Sbjct: 4212 EMNEIL 4217



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2658 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2763

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2764 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2822

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2823 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2882

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2883 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3241 GYRDPYTGQSVSLFQALKKGLI 3262



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 2108

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 2109 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2166

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2167 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2402 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2454 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2510 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2540

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2656

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2713

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2714 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2757

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2758 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2811

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2812 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2860

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2861 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2901

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 3022 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 3076

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 3077 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 3136

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 3137 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3196

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3197 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3256

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3257 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3308



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3902 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3961

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3962 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 4020

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4259

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4260 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4304



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 4145 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4204

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4205 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4255 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4302

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4303 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4362

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4363 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4422

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4423 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4482

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4483 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4542

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4543 VPLDEALQRGTVDARTAQKLRDV 4565



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3236 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3295

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3296 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3355

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3356 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3413

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3414 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3470

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3471 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3530

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3531 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3590

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3591 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3648

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3649 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3704



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3459 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3518

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3519 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3576

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3577 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3636

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3637 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3696

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3697 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3756

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3757 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3816

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3817 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3876

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3877 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3933



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 4117 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4174

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4175 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4232

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4233 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4292

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4293 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4352

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4353 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4412

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4413 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4472

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4473 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4532

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4533 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4592

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4593 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4629



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3162 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3221

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3222 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3279

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3280 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3339

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3340 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3383

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3384 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3429

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3430 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3489

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3490 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3525



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1693 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1864

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1920

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2161 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2208

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2266

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2267 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2386 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2445 AEKMLKEK 2452


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1432



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3639 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3697

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3698 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3755

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3756 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3815

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3816 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3872

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3873 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3932

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3933 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 3992

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 3993 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4052

Query: 1596 NTASIL 1601
                IL
Sbjct: 4053 EMNEIL 4058



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2499 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2604

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2605 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2663

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2664 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2723

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2724 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2781

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2782 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2841

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2842 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2901

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2902 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2961

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2962 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3021

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3022 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3081

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3082 GYRDPYTGQSVSLFQALKKGLI 3103



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1949

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1950 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2007

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2008 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2243 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2295 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2351 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2381

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2497

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2554

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2555 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2598

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2599 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2652

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2653 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2701

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2702 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2742

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2863 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2917

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2918 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2977

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 2978 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3037

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3038 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3097

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3098 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3149



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3743 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3802

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3803 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3861

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3862 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3921

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3922 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 3981

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 3982 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4041

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4042 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4100

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4101 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4145



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 3986 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4045

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4046 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4096 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4143

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4144 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4203

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4204 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4263

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4264 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4323

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4324 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4383

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4384 VPLDEALQRGTVDARTAQKLRDV 4406



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3077 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3136

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3137 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3196

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3197 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3254

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3255 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3311

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3312 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3371

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3372 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3431

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3432 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3489

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3490 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3545



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3300 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3359

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3360 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3417

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3418 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3477

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3478 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3537

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3538 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3597

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3598 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3657

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3658 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3717

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3718 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3774



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3958 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4015

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4016 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4073

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4074 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4133

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4134 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4193

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4194 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4253

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4254 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4313

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4314 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4373

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4374 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4433

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4434 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4470



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3003 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3062

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3063 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3181 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3224

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3225 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3270

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3271 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3330

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3331 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3366



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1534 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1705

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1761

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2002 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2049

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2107

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2108 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2227 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2286 AEKMLKEK 2293


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 504  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 564  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 624  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 684  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 744  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 804  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 864  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 984  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1282

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1399

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1400 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1440



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3647 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3705

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3706 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3763

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3764 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3823

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3824 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3880

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3881 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3940

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3941 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4000

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4001 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4060

Query: 1596 NTASIL 1601
                IL
Sbjct: 4061 EMNEIL 4066



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2270 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2507 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2559

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2612

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2613 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2671

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2672 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2731

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2732 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2789

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2790 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2849

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2850 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2909

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2910 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2969

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 2970 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3029

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3030 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3089

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3090 GYRDPYTGQSVSLFQALKKGLI 3111



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1957

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1958 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2015

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2016 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2251 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2303 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2359 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2389

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2449

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2505

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2562

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2563 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2606

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2607 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2660

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2661 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2709

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2710 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2750

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2751 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2810

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2811 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2870

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2871 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2925

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2926 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2985

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 2986 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3045

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3046 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3105

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3106 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3157



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3751 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3810

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3811 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3869

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3870 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3929

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3930 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 3989

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 3990 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4049

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4050 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4108

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4109 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4153



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 3994 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4053

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4054 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4103

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4104 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4151

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4152 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4211

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4212 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4271

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4272 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4331

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4332 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4391

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4392 VPLDEALQRGTVDARTAQKLRDV 4414



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3085 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3144

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3145 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3204

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3205 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3262

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3263 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3319

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3320 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3379

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3380 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3439

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3440 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3497

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3498 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3553



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3308 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3367

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3368 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3425

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3426 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3485

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3486 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3545

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3546 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3605

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3606 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3665

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3666 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3725

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3726 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3782



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 3966 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4023

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4024 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4081

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4082 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4141

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4142 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4201

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4202 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4261

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4262 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4321

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4322 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4381

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4382 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4441

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4442 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4478



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3011 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3070

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3071 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3128

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3129 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3188

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3189 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3232

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3233 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3278

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3279 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3338

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3339 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3374



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 376 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 435

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 436 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 473



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1542 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1713

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1769

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2010 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2057

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2115

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2116 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2234

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2235 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2294 AEKMLKEK 2301


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 545  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 605  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 665  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 725  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 785  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 845  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 905  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 965  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383

Query: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1481



 Score =  124 bits (312), Expect = 1e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 3688 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3746

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 3747 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3804

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 3805 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3864

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 3865 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3921

Query: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 3922 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3981

Query: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 3982 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4041

Query: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 4042 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4101

Query: 1596 NTASIL 1601
                IL
Sbjct: 4102 EMNEIL 4107



 Score =  119 bits (298), Expect = 5e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250

Query: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367

Query: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487

Query: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547

Query: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 2548 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2600

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2653

Query: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 2654 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2712

Query: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 2713 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2772

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 2773 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2830

Query: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 2831 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2890

Query: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 2891 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2950

Query: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
            I                 LR    G I  E + +++                       +
Sbjct: 2951 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3010

Query: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 3011 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3070

Query: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 3071 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3130

Query: 1572 ALYIPESSQVIGLDAAKQLGII 1593
                P + Q + L  A + G+I
Sbjct: 3131 GYRDPYTGQSVSLFQALKKGLI 3152



 Score =  109 bits (273), Expect = 4e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1998

Query: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 1999 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2056

Query: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 2057 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111

Query: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 2292 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 2344 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 2400 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2430

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2546

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2603

Query: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 2604 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2647

Query: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 2648 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2701

Query: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 2702 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2750

Query: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 2751 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2791

Query: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851

Query: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 2912 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2966

Query: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 2967 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 3026

Query: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 3027 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3086

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 3087 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3146

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 3147 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3198



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 3792 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3851

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 3852 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3910

Query: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 3911 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3970

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 3971 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4030

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 4031 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4090

Query: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 4091 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4149

Query: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 4150 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4194



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 4035 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4094

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 4095 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4144

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 4145 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4192

Query: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 4193 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4252

Query: 1452 -------AQLLSG-------------------------------------------GLIN 1461
                   A +LSG                                           G+++
Sbjct: 4253 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4312

Query: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 4313 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4372

Query: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 4373 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4432

Query: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
            + LD A Q G +D  TA  L+++
Sbjct: 4433 VPLDEALQRGTVDARTAQKLRDV 4455



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 3126 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3185

Query: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 3186 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3245

Query: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 3246 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3303

Query: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 3304 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3360

Query: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 3361 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3420

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 3421 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3480

Query: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 3481 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3538

Query: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 3539 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3594



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 97/477 (20%), Positives = 190/477 (39%), Gaps = 81/477 (16%)

Query: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 3349 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3408

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 3409 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3466

Query: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 3467 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3526

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC---- 1426
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +        
Sbjct: 3527 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3586

Query: 1427 ----------------------GRNISILRAAHEGLIDRETMFRLLS------------- 1451
                                  G  +S+       LI  E   +L++             
Sbjct: 3587 EEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMI 3646

Query: 1452 ---AQLLSGGLINSNSG--------QRMTVEEAVREGVIDRDT----------------A 1484
                +++    I    G        +R+T E+     +I  +T                A
Sbjct: 3647 IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEA 3706

Query: 1485 SSILTYQVQTG---GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG 1541
             S   Y   TG   G+      + L++ +A++  L+++  A L+LEAQ     L+ P  G
Sbjct: 3707 ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKG 3766

Query: 1542 EIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
            E      ++++ L+  EL  ++L+  + +     P + Q I L  A +  +I    A
Sbjct: 3767 ERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEA 3823



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 4007 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4064

Query: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 4065 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4122

Query: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 4123 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4182

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 4183 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4242

Query: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 4243 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4302

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 4303 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4362

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 4363 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4422

Query: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 4423 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4482

Query: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
                  ++L    Q     Y P S    G  A  + G
Sbjct: 4483 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4519



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 3052 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3111

Query: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 3112 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3229

Query: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 3230 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3273

Query: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 3274 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3319

Query: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 3320 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3379

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 3380 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3415



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 1583 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697

Query: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1754

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1810

Query: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870

Query: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050

Query: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 2051 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2098

Query: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
            + +   +K +    +Q         QA LR     D                        
Sbjct: 2157 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215

Query: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275

Query: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 2276 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334

Query: 1370 FSKVLERQ 1377
              K+L+ +
Sbjct: 2335 AEKMLKEK 2342


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  596 bits (1537), Expect = e-169
 Identities = 391/1412 (27%), Positives = 699/1412 (49%), Gaps = 124/1412 (8%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1086 TLMTQYIKFAGDSLKR-------------LEEEEKSLEEEKKEHVEKAK----ELQKWVS 1128
            T    Y +F  + LK              LEEE +   +   E+  K K     LQK+ +
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067

Query: 1129 NISK---TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1185
              S+    L   E+  +      K + + +     Q+ E  + I     +  D+     R
Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE--KRRR 1125

Query: 1186 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQ 1245
              +E +    +  Y+ L  +  +Q ++          EK  K     I++          
Sbjct: 1126 KSVEDRFDQQKNDYDQL--QKARQCEKENLGWQKLESEKAIKEKEYEIER---------- 1173

Query: 1246 AVLRGLIDYD-TGIRLLETQL-MISGLISPELRKCFDLKDAKSHGLIDEQILCQLK---- 1299
              LR L+  + T  R  E +L   S  I     +C  +   +   L+  ++L Q K    
Sbjct: 1174 --LRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1231

Query: 1300 ----ELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLT 1355
                EL++AK  + A +      L+   Q +  +    K            I +  E+  
Sbjct: 1232 RLEDELNRAKSTLEAETRVK-QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1290

Query: 1356 LQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVR 1415
             +K   ++ +   L +++   +  C+  ++  T E  S ++  +RS  Q       L  R
Sbjct: 1291 REKNSLRSEI-ERLQAEIKRIEERCRRKLEDSTRETQSQLE-TERSRYQREIDK--LRQR 1346

Query: 1416 PQEGGRIT-LKCGRNISILRAAHEGLIDRETMFRLLSAQLL------------------- 1455
            P    R T  +C   +   +   +GL  + T  +L   QL+                   
Sbjct: 1347 PYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA 1406

Query: 1456 ---------SGGLINSNSG--QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAK 1504
                     +G +  +++   ++ ++ EA R+ +I  ++   +L  Q  TGGII  +  +
Sbjct: 1407 SEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNE 1466

Query: 1505 RLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL 1564
            +LTVD A+  DLI       +  A++   G   P SG+    S ++++ LI  E   ++L
Sbjct: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLL 1526

Query: 1565 NGRQKIAALYIPESSQVIGLDAAKQLGIIDNN 1596
              +     +  P +S  +  D A   G+ID +
Sbjct: 1527 EAQIASGGVVDPVNSVFLPKDVALARGLIDRD 1558



 Score =  150 bits (378), Expect = 2e-35
 Identities = 188/946 (19%), Positives = 400/946 (42%), Gaps = 83/946 (8%)

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
            +DS ES  F  S+     + +N  K  + E+    ++ E+ + +  L  + +++  L+L 
Sbjct: 909  QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
            +    L   +  P++R  + +S   +  QE        +  +L T +     F S+   S
Sbjct: 967  SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023

Query: 815  SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871
                 L++ ++ V+ + +      +S   +K K ++  L+  QA  ++   KL   +  +
Sbjct: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931
             +A +  K+  +NL     Q +   ++  ++ + +EDE ++ K++ D            F
Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132

Query: 932  DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
            D  K   DQL +  Q     +  +  + E   K  +Y  +    L   +Q+  T +R+ +
Sbjct: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
                + S  +    NQ   +V E E    K+    K  EQ  A ++  E +    ++ ++
Sbjct: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245

Query: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
            ++ +    ++R++     I  +    +T+Y+              ++++++E E +  E 
Sbjct: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-----------KEEAIRKIESEREKSER 1291

Query: 1112 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-Q 1170
            EK     + + LQ  +  I       E+  +      + +  ++ T++ +    +  + Q
Sbjct: 1292 EKNSLRSEIERLQAEIKRIE------ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1345

Query: 1171 LFLAKHGDKMTDEER---------NELEKQVKTLQ-ESYNLLFSESLKQLQESQTSGDVK 1220
                 H +  T+ E          + L K+V  +Q     L+   +L +L + + S + +
Sbjct: 1346 RPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVE-E 1404

Query: 1221 VEEKLDKVIAGT-----IDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPEL 1275
            V  ++   + G         +  E  S+ +A  + LI  ++ + LLE Q    G+I P  
Sbjct: 1405 VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHR 1464

Query: 1276 RKCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIK 1334
             +   +  A +  LID     Q+    KA        S  T+ V +A+ +++I     ++
Sbjct: 1465 NEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMR 1524

Query: 1335 VLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSL 1394
            +LE  +++G +V P     L    A  + L+   L+  + + ++  K+ +DP T +KVS 
Sbjct: 1525 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY 1584

Query: 1395 IDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL 1454
            + + +R  ++ +TG+ LL V+ +      ++  + +++      G++   T+  L S Q+
Sbjct: 1585 VQLKERCRIEPHTGLLLLSVQKRSMSFQGIR--QPVTVTELVDSGILRPSTVNELESGQI 1642

Query: 1455 ------------LSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGI 1497
                        L G     G+ N  + Q++ + EA++ G++   TA  +L  Q  TG I
Sbjct: 1643 SYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 1702

Query: 1498 IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITN 1557
            +      RL V+EA +  L+       +L A+R   G   P +G I     ++ +ELI  
Sbjct: 1703 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 1762

Query: 1558 ELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
                ++L  +     +  P+ S  + +D A + G  +   + IL +
Sbjct: 1763 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808



 Score = 95.1 bits (235), Expect = 9e-19
 Identities = 191/968 (19%), Positives = 390/968 (40%), Gaps = 144/968 (14%)

Query: 745  EVRNIRLRLENCEDRLIRQIRT--------PLERDDLH----ESVFRITEQEKLKKELER 792
            E+ + + R ++ EDR  +Q             E+++L     ES   I E+E   + L  
Sbjct: 1117 EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRV 1176

Query: 793  LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN------QVYSMSSTYIDKLK 846
            L  + GT   + E     A AS+ +   +++   V+Q         +V       + +L+
Sbjct: 1177 LLQEEGTRKREYEN--ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1234

Query: 847  TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS----TLKQWRSEVDEKRQV 902
                  K+T  AE  VK  +   CE++ +  D N  +   S     +++  SE ++  + 
Sbjct: 1235 DELNRAKSTLEAETRVK--QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE 1292

Query: 903  FHALEDELQKAKA------------ISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV 950
             ++L  E+++ +A            + D   +T  + + +   ++ + D+L +R    H 
Sbjct: 1293 KNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR 1352

Query: 951  Q--------IDNRLRDLEGIGK---SLKYYRDTY---HPLDDWIQQVETTQRKIQENQP- 995
            +        +D      +G+ K   +++ Y         LD  ++  ++ +    E QP 
Sbjct: 1353 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPF 1412

Query: 996  -ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
               + ++A      K   S +E K+ K+   +       +TV   E Q  T   ++D  +
Sbjct: 1413 LRGAGSIAGASASPKEKYSLVEAKRKKLISPE-------STVMLLEAQAAT-GGIIDPHR 1464

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
                ++  + S+    + +F D +  Y A   +      F+G ++   E  +K+L + + 
Sbjct: 1465 N---EKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET 1521

Query: 1115 ------------------EHVEKAKELQKWVSNISKTL-------KDAEKAGKPPFSKQK 1149
                                V   K++      I + L       +D++K    P +K+K
Sbjct: 1522 GMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKK 1581

Query: 1150 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1209
            +S  ++   KE+      T  L L+     M+ +   +    V  L +S  +L   ++ +
Sbjct: 1582 VSYVQL---KERCRIEPHTGLLLLSVQKRSMSFQGIRQ-PVTVTELVDS-GILRPSTVNE 1636

Query: 1210 LQESQTSGDVKVEEKLD-----KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
            L+  Q S D   E   D       IAG  ++TT + L +++A+  GL+   T + LLE Q
Sbjct: 1637 LESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQ 1696

Query: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDA 1321
                 ++ P       +++A   GL+  +   + K LS  + +     P T   I +  A
Sbjct: 1697 AATGFIVDPVSNLRLPVEEAYKRGLVGIEF--KEKLLSAERAVTGYNDPETGNIISLFQA 1754

Query: 1322 LAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCK 1381
            + + +I +   I++LE  ++TG ++ P    +L +  A+++   +  L   + +  +  K
Sbjct: 1755 MNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK 1814

Query: 1382 DLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRP-----QEGGRITLK----------C 1426
               DP T E ++ + + +R    E TG+ LLP++      Q   + TL+           
Sbjct: 1815 GFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPET 1874

Query: 1427 GRNISILRAAHEGLIDRETMFRLLSAQL------LSGG-------LINSNSGQRMTVEEA 1473
             + +S+  A  +GLID ET   L   +       ++G        L++  +G +  +++A
Sbjct: 1875 NKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDA 1934

Query: 1474 VREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV 1533
            + +G++DR         Q ++G +  +  A  +++   V       S     + +   + 
Sbjct: 1935 IDKGLVDRKFFD-----QYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH- 1988

Query: 1534 GLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGII 1593
                  S     T SS++   I +      L     IAA++  E+ + I +    + GI+
Sbjct: 1989 -----ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIV 2043

Query: 1594 DNNTASIL 1601
            D+ T   L
Sbjct: 2044 DSITGQRL 2051



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 97/390 (24%), Positives = 164/390 (42%), Gaps = 54/390 (13%)

Query: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN----LLFSESLKQLQESQT 1215
            E+LSE L           D  T+E    L+ + + +++       L   E  KQ+Q SQ 
Sbjct: 1800 EELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQ- 1858

Query: 1216 SGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ-----LMISG- 1269
                  +  L K     +D  T + +SV +A  +GLIDY+T   L E +     + I+G 
Sbjct: 1859 ------KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGS 1912

Query: 1270 -------LISPELRKCFDLKDAKSHGLIDEQI----------LCQLKELSKAKEIISAAS 1312
                   L+  +    +D++DA   GL+D +           L Q  ++   K  +  +S
Sbjct: 1913 DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSS 1972

Query: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372
                 V D +  S   ES++       +ST S V   T              + S+ FS 
Sbjct: 1973 SMGSGVSDDVFSSSRHESVS------KISTISSVRNLT--------------IRSSSFSD 2012

Query: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432
             LE  +    + D    EK+S+ + ++R  +   TG  LL  +   GG I    G+ +S+
Sbjct: 2013 TLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSL 2072

Query: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
              A  +G+ID++   RL  AQ    G       ++M+  EAV+E  +  +     L +Q 
Sbjct: 2073 QDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY 2132

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSA 1522
             TGG++      R++ +EA++   I   +A
Sbjct: 2133 LTGGLVDPEVHGRISTEEAIRKGFIDGRAA 2162



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 93/458 (20%), Positives = 190/458 (41%), Gaps = 67/458 (14%)

Query: 1210 LQESQTSGDVKVE--EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
            ++E+   G V +E  EKL   ++ + G  D  TG ++S+FQA+ + LI+   GIRLLE Q
Sbjct: 1713 VEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ 1772

Query: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALA 1323
            +   G+I P+      +  A   G  +E++   L + S   K      +   +  L    
Sbjct: 1773 IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKE 1832

Query: 1324 QSMITESMAIKVLEIL-----LSTGS----------LVIPATGEQLTLQKAFQQNLVSSA 1368
            + +  E   + +L +      + T            +V P T +++++Q+A+++ L+   
Sbjct: 1833 RCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYE 1892

Query: 1369 LFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTL------QENTGM 1409
             F ++ E++   ++             L+D  T  +  + D + +  +      Q  +G 
Sbjct: 1893 TFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS 1952

Query: 1410 WLLPVRPQEGGRITLKCGRNIS-----------ILRAAHEGLIDRETMFRLLSAQLLSGG 1458
              L    Q    I+LK G   S              + HE +    T+  + +  + S  
Sbjct: 1953 LSLT---QFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSS 2009

Query: 1459 -------------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKR 1505
                         + ++ + +++++ E +  G++D  T   +L  Q  TGGII     ++
Sbjct: 2010 FSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069

Query: 1506 LTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILN 1565
            L++ +AV   +I    A  +  AQ+ ++G       +    + +++++ +  E   + L 
Sbjct: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
             +     L  PE    I  + A + G ID   A  L++
Sbjct: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQD 2167



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 32/246 (13%)

Query: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESL--KQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235
            D +    R+E   ++ T+    NL    S     L+ES               IA   D 
Sbjct: 1980 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSP-------------IAAIFDT 2026

Query: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295
               E +S+ + + RG++D  TG RLLE Q    G+I P   +   L+DA S G+ID+ + 
Sbjct: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086

Query: 1296 CQLKELSKA---------KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346
             +LK   KA         K+ +SAA        +A+ +  +      + LE    TG LV
Sbjct: 2087 TRLKPAQKAFIGFEGVKGKKKMSAA--------EAVKEKWLPYEAGQRFLEFQYLTGGLV 2138

Query: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406
             P    +++ ++A ++  +      ++ +  +  K L  P T  K+S  D + RS +++ 
Sbjct: 2139 DPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDI 2198

Query: 1407 TGMWLL 1412
            TG+ LL
Sbjct: 2199 TGLRLL 2204



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 155/853 (18%), Positives = 335/853 (39%), Gaps = 107/853 (12%)

Query: 864  LYETKLCE---EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920
            LY+ K  +   E     D N +   ++  K   SE+  KR       +E+QK   +    
Sbjct: 902  LYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK----SEEVQKIAELCANS 957

Query: 921  FKTYKERDLDFDWHKEKA------DQLVERWQNVHVQ--IDNRLRDLEGIGKSLKYYR-- 970
             K Y+ +   +    E          +++    V +Q   D   R +E + +S  YYR  
Sbjct: 958  IKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFL 1017

Query: 971  -DTYHPLDDWI---QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ 1026
             +    L+D      ++E  + +++  +  NS+      N+ K L   ++  Q+   EC 
Sbjct: 1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQKYQA---ECS 1070

Query: 1027 KYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVT 1086
            ++  + ++      L+ +  +A +D +          + + D    +  +L  +    +T
Sbjct: 1071 QFKAKLAS------LEELKRQAELDGKSA--------KQNLDKCYGQIKELNEK----IT 1112

Query: 1087 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEH--VEKAKELQKWVSNISKTLKDAEKAGKPP 1144
             +T  I+   D  +R +  E   +++K ++  ++KA++ +K   N+     ++EKA K  
Sbjct: 1113 RLTYEIE---DEKRRRKSVEDRFDQQKNDYDQLQKARQCEK--ENLGWQKLESEKAIKEK 1167

Query: 1145 ---FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD--EERNELEKQVKTL-QES 1198
                 + ++  +E  T+K +    L      + +  ++ T   +ER  L  ++K L Q+ 
Sbjct: 1168 EYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1227

Query: 1199 YNLLFSESLKQLQESQTSGDVKVEEKLD---KVIAGTIDQTTGEVLSVFQAVLRGLIDYD 1255
              L   E      +S    + +V+++L+   + I   ++Q   +     +A         
Sbjct: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA--------- 1278

Query: 1256 TGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEI-ISAASPT 1314
              IR +E++   S      LR   +   A+    I+E+   +L++ ++  +  +      
Sbjct: 1279 --IRKIESEREKSEREKNSLRSEIERLQAEIKR-IEERCRRKLEDSTRETQSQLETERSR 1335

Query: 1315 TIPVLDALAQSMITESMAIKV-LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
                +D L Q         +   E  + T  LV     +++T  + ++  L+      K+
Sbjct: 1336 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1395

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISIL 1433
            L+ +   +++                +  L+    +      P+E            S++
Sbjct: 1396 LKGKKSVEEVASEI------------QPFLRGAGSIAGASASPKE----------KYSLV 1433

Query: 1434 RAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQ 1493
             A  + LI  E+   LL AQ  +GG+I+ +  +++TV+ A+   +ID D    I   +  
Sbjct: 1434 EAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKA 1493

Query: 1494 TGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQE 1553
              G       K ++V EA++ +LI   + + +LEAQ    G++ P +    P   +L + 
Sbjct: 1494 ITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARG 1553

Query: 1554 LITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDL 1613
            LI  +L   + + R        P + + +     K+   I+ +T  +L  +++  +    
Sbjct: 1554 LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL--LSVQKRSMSF 1611

Query: 1614 GDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSY 1673
              +         +     +PSTV++    +  +D       +  E  K        I   
Sbjct: 1612 QGIRQPVTVTELVDSGILRPSTVNELESGQISYD-------EVGERIKDFLQGSSCIAGI 1664

Query: 1674 MDANTGQRLLLYD 1686
             +  T Q+L +Y+
Sbjct: 1665 YNETTKQKLGIYE 1677


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  561 bits (1447), Expect = e-159
 Identities = 308/992 (31%), Positives = 548/992 (55%), Gaps = 69/992 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052

Query: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103

Query: 1206 SLKQLQESQT--SGDVKVEEKLDKVIAGTIDQ 1235
             +K+L E  T  + +++ E++  K +    DQ
Sbjct: 1104 -IKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134



 Score =  160 bits (404), Expect = 2e-38
 Identities = 262/1346 (19%), Positives = 539/1346 (40%), Gaps = 163/1346 (12%)

Query: 298  RTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 357
            + E+ ++L  V +H     +  R   E E ++ +  I EI M         +    L +Q
Sbjct: 1185 KREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKE------DDSKNLRNQ 1238

Query: 358  YAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY-HA 416
              +L   +R+ +  +  L++ + +AT +      +  EE A       + I +KK +   
Sbjct: 1239 LDRLSRENRDLKDEIVRLNDSILQATEQ-----RRRAEENALQQKACGSEIMQKKQHLEI 1293

Query: 417  ELMRELDQKEENI----KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 472
            EL + + Q+ E+     +S++E A+ +  +N         ++   + +W +  +L +   
Sbjct: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353

Query: 473  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 532
             + +E        N  +   +  +     +  +   D S    ++++L +E+    EE+ 
Sbjct: 1354 NYDEE---IISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIK 1410

Query: 533  QYKSTIA----NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLA 588
            + K+T+     NL    + I Q K   S+   +     K   +    ++T  + +E V  
Sbjct: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR-----KQQLEVELRQVTQMRTEESVRY 1465

Query: 589  NNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMK 648
              S                +     T+   NKE   L   I+++  +   L  + +  ++
Sbjct: 1466 KQS----------------LDDAAKTIQDKNKEIERLKQLIDKETNDRKCL-EDENARLQ 1508

Query: 649  SVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDI 708
             V    Y + + +      +  +K       +Q L+ L+  +E     SQE  V    DI
Sbjct: 1509 RV---QYDLQKANSSATETINKLKVQ-----EQELTRLRIDYERV---SQERTV-KDQDI 1556

Query: 709  TQLE---KEVNVCKQYYQELLKSAEREEQEESVYNLYISE-VRNIRLRLENCEDRLIRQI 764
            T+ +   KE+ + KQ  +E L   +R   E+S     + E +  +R  L+    ++    
Sbjct: 1557 TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI---- 1612

Query: 765  RTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
             T L +     S+ +   ++ L+++ + L   L       EE       SS V  LR +L
Sbjct: 1613 -TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL---RRLSSEVEALRRQL 1668

Query: 825  NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA-EALVKLYETKLCEEEAVIADKNNIE 883
                +++ Q +  +  +   ++  +  L  ++   E L  L E    E   +  +  N+ 
Sbjct: 1669 LQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLR 1728

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
                 L++ RSE D  +   +A   EL+    IS+      +    D    +E   Q +E
Sbjct: 1729 LEYDDLRRGRSEADSDK---NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE 1785

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLAT 1003
            ++Q   ++  NR+++ +     +   R++              + K+ E      + L  
Sbjct: 1786 KFQKQALEASNRIQESKNQCTQVVQERESL-----------LVKIKVLEQDKARLQRLED 1834

Query: 1004 QLNQQKM-LVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1062
            +LN+ K  L +E  +KQ    E Q+     +     Y  +    R +   ++KS  ++  
Sbjct: 1835 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1894

Query: 1063 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1122
            ++S  + +  E                         +KR+EE  +   E+     +   E
Sbjct: 1895 LRSEIERLQAE-------------------------IKRIEERCRRKLEDSTRETQSQLE 1929

Query: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEE----ISTKK---EQLSEALQTIQLFLAK 1175
             ++     S+  ++ +K  + P+   + +  E    + T K   + L + +  +QL+  +
Sbjct: 1930 TER-----SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1984

Query: 1176 HGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235
              DK T    ++L K  K+++E    + SE    L+ + +        K           
Sbjct: 1985 LIDKTT---LDKLLKGKKSVEE----VASEIQPFLRGAGSIAGASASPK----------- 2026

Query: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295
               E  S+ +A  + LI  ++ + LLE Q    G+I P   +   +  A +  LID    
Sbjct: 2027 ---EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083

Query: 1296 CQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQL 1354
             Q+    KA        S  T+ V +A+ +++I     +++LE  +++G +V P     L
Sbjct: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143

Query: 1355 TLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPV 1414
                A  + L+   L+  + + ++  K+ +DP T +KVS + + +R  ++ +TG+ LL V
Sbjct: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV 2203

Query: 1415 RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL------------LSG----- 1457
            + +      ++  + +++      G++   T+  L S Q+            L G     
Sbjct: 2204 QKRSMSFQGIR--QPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261

Query: 1458 GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLI 1517
            G+ N  + Q++ + EA++ G++   TA  +L  Q  TG I+      RL V+EA +  L+
Sbjct: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321

Query: 1518 TSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPE 1577
                   +L A+R   G   P +G I     ++ +ELI      ++L  +     +  P+
Sbjct: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381

Query: 1578 SSQVIGLDAAKQLGIIDNNTASILKN 1603
             S  + +D A + G  +   + IL +
Sbjct: 2382 ESHRLPVDIAYKRGYFNEELSEILSD 2407



 Score =  118 bits (295), Expect = 1e-25
 Identities = 282/1490 (18%), Positives = 570/1490 (38%), Gaps = 189/1490 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
            + SL      +    M+F+ +  N   E+  + D++E    +   E    + K+    + 
Sbjct: 909  QDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKI--AELCANSIKDYELQLA 966

Query: 324  EFESSLKEA-----KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNF 378
             + S L+       K + IQ  + + L  A  +H   ++Y +LL  S +  R L  +   
Sbjct: 967  SYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH---ARYIELLTRSGDYYRFLSEMLKS 1023

Query: 379  VS--RATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR-ELDQKEENIKSVQEI 435
            +   +  N  I + E EE  +A D +  N N  +  D + +  + E  Q +  + S++E+
Sbjct: 1024 LEDLKLKNTKIEVLE-EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL 1082

Query: 436  AEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 495
              Q  L+   A+  ++     ++     I +L   +E   +   +  + F+  K   D L
Sbjct: 1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL 1142

Query: 496  RNLKDAIQRKYSCDRSSS----------IHKLEDLVQESMEEKEELLQ--------YKST 537
            +  +   +      +  S          I +L  L+QE    K E           Y   
Sbjct: 1143 QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEE 1202

Query: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
            ++NL  K +T I +         KT+I           EI++ K+D+     N       
Sbjct: 1203 MSNLRNKYETEINIT--------KTTIK----------EISMQKEDDSKNLRNQ------ 1238

Query: 598  VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
                             +   ++E  DL + I +   ++L    +     ++ +      
Sbjct: 1239 -----------------LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQ----- 1276

Query: 658  NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNV 717
                +   S +   K  L  E +QV+   Q R ED     Q  +  +   I    KE+  
Sbjct: 1277 ---QKACGSEIMQKKQHLEIELKQVM---QQRSEDNARHKQSLEE-AAKTIQDKNKEIER 1329

Query: 718  CKQYYQELLKSA-EREEQEESVYNLYISEVRNIRLRLE---NCEDRLIRQIRTPLERDD- 772
             K  +QE  K   E E +   V N Y  E+ +++ + E   N     I Q+    E D  
Sbjct: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389

Query: 773  -LHESVFRIT-EQEKLKKELERLKDDLGTITNKC----EEFFSQAAASSSVPTLRSELNV 826
                 +  +T E   L +E++RLK+ L   T       E+   Q A  S V   + +L V
Sbjct: 1390 GYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEV 1449

Query: 827  VLQNMNQVYSMSSTYI-----DKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 881
             L+ + Q+ +  S        D  KT+       +  E L +L + +  + + +  +   
Sbjct: 1450 ELRQVTQMRTEESVRYKQSLDDAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENAR 1506

Query: 882  IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
            ++ +   L++  S   E        E EL + +   + + +    +D D    +    +L
Sbjct: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566

Query: 942  VERWQNVHVQIDNRLR---------------DLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
              + Q V  ++ NRL+               +LEG+ +SLK        L   ++Q    
Sbjct: 1567 QLQKQKVEEEL-NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625

Query: 987  QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
            +++ +++  +    L   L +++    E+    S+++  ++   Q   +VK   L+   +
Sbjct: 1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHF 1685

Query: 1047 RAMVDSQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL 1102
            +  ++ + +S     ++  R+QS  + + +E + L      L  L  +Y     D L+R 
Sbjct: 1686 QKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEE---LRNLRLEY-----DDLRRG 1737

Query: 1103 EEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQL 1162
              E  S  ++    +E   +LQ  +SN ++TL+           ++ +  +EI   ++Q 
Sbjct: 1738 RSEADS--DKNATILELRSQLQ--ISN-NRTLELQGLINDLQRERENLR-QEIEKFQKQA 1791

Query: 1163 SEALQTIQLFLAKHGDKMTDEERNELEKQVKTL-QESYNLLFSESLKQLQESQTSGDVKV 1221
             EA   IQ   +K+      +ER  L  ++K L Q+   L   E      +S    + +V
Sbjct: 1792 LEASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1849

Query: 1222 EEKLD---KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKC 1278
            +++L+   + I   ++Q   +     +A           IR +E++   S      LR  
Sbjct: 1850 KQRLECEKQQIQNDLNQWKTQYSRKEEA-----------IRKIESEREKSEREKNSLRSE 1898

Query: 1279 FDLKDAKSHGLIDEQILCQLKELSKAKEI-ISAASPTTIPVLDALAQSMITESMAIKV-L 1336
             +   A+    I+E+   +L++ ++  +  +          +D L Q         +   
Sbjct: 1899 IERLQAEIKR-IEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTEC 1957

Query: 1337 EILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLID 1396
            E  + T  LV     +++T  + ++  L+      K+L+ +   +++             
Sbjct: 1958 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEI--------- 2008

Query: 1397 MVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLS 1456
               +  L+    +      P+E            S++ A  + LI  E+   LL AQ  +
Sbjct: 2009 ---QPFLRGAGSIAGASASPKE----------KYSLVEAKRKKLISPESTVMLLEAQAAT 2055

Query: 1457 GGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDL 1516
            GG+I+ +  +++TV+ A+   +ID D    I   +    G       K ++V EA++ +L
Sbjct: 2056 GGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNL 2115

Query: 1517 ITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIP 1576
            I   + + +LEAQ    G++ P +    P   +L + LI  +L   + + R        P
Sbjct: 2116 IDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDP 2175

Query: 1577 ESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTV 1636
             + + +     K+   I+ +T  +L  +++  +      +         +     +PSTV
Sbjct: 2176 VTKKKVSYVQLKERCRIEPHTGLLL--LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTV 2233

Query: 1637 HDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYD 1686
            ++    +  +D       +  E  K        I    +  T Q+L +Y+
Sbjct: 2234 NELESGQISYD-------EVGERIKDFLQGSSCIAGIYNETTKQKLGIYE 2276



 Score =  111 bits (278), Expect = 1e-23
 Identities = 275/1424 (19%), Positives = 574/1424 (40%), Gaps = 215/1424 (15%)

Query: 311  HLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQER 370
            H ++ +   + I++    ++  K +E Q  A  +  Y  +L ++ + Y + + + +NQ  
Sbjct: 1309 HKQSLEEAAKTIQDKNKEIERLK-AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ-- 1365

Query: 371  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE----LMRELDQKE 426
              +T  N      ++L    +KEE+   Y    +  N+ R+    +E    L   L Q  
Sbjct: 1366 -FETEINITKTTIHQLTM--QKEEDTSGY--RAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
            EN++ V+E  +Q                   +   S + Q  Q +E  +++ T       
Sbjct: 1421 ENLRRVEEDIQQ------------------QKATGSEVSQRKQQLEVELRQVTQM----- 1457

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL---------LQYKST 537
              +E+  Y ++L DA   K   D++  I +L+ L+ +   +++ L         +QY   
Sbjct: 1458 RTEESVRYKQSLDDAA--KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQ 1515

Query: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI---EITIYKDD--ECVLANNSH 592
             AN     +TI +LK +  +   +  I  + +   R +   +IT +++   E  L     
Sbjct: 1516 KAN-SSATETINKLKVQEQELT-RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKV 1573

Query: 593  RAKWKVISPTGNE------AMVPSVCFTVPPPNKEAVDLANRIEQQYQ-NVLTLWHESHI 645
              +   +  T +E       +   +        ++A+ + N  +Q  Q +++    E  +
Sbjct: 1574 EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633

Query: 646  NMKSVVSWHYL-----INEIDRIRASNVASIKTMLPGEHQQVL-SNLQSR-FEDFLEDSQ 698
              +  V   +L       E  R  +S V +++  L  E + V  ++L++  F+  +ED  
Sbjct: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693

Query: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED 758
             S       + + + E+   +   + L K     E+E     L   ++R  R   ++ ++
Sbjct: 1694 RS-------LNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN 1746

Query: 759  RLIRQIRTPL--------ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ 810
              I ++R+ L        E   L   + R  E+E L++E+E+ +      +N+ +E  +Q
Sbjct: 1747 ATILELRSQLQISNNRTLELQGLINDLQR--ERENLRQEIEKFQKQALEASNRIQESKNQ 1804

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLC 870
                + V   R  L V ++ + Q  +      D+L       K+T  AE  VK  +   C
Sbjct: 1805 C---TQVVQERESLLVKIKVLEQDKARLQRLEDELNRA----KSTLEAETRVK--QRLEC 1855

Query: 871  EEEAVIADKNNIENLIS----TLKQWRSEVDEKRQVFHALEDELQKAKA----------- 915
            E++ +  D N  +   S     +++  SE ++  +  ++L  E+++ +A           
Sbjct: 1856 EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1915

Query: 916  -ISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ--------IDNRLRDLEGIGK-- 964
             + D   +T  + + +   ++ + D+L +R    H +        +D      +G+ K  
Sbjct: 1916 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975

Query: 965  -SLKYYRDTY---HPLDDWIQQVETTQRKIQENQP--ENSKTLATQLNQQKMLVSEIEMK 1018
             +++ Y         LD  ++  ++ +    E QP    + ++A      K   S +E K
Sbjct: 1976 TAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAK 2035

Query: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078
            + K+   +       +TV   E Q  T   ++D  +    ++  + S+    + +F D +
Sbjct: 2036 RKKLISPE-------STVMLLEAQAAT-GGIIDPHRN---EKLTVDSAIARDLIDFDDRQ 2084

Query: 1079 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK------------------EHVEKA 1120
              Y A   +      F+G ++   E  +K+L + +                     V   
Sbjct: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144

Query: 1121 KELQKWVSNISKTL-------KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
            K++      I + L       +D++K    P +K+K+S  ++   KE+      T  L L
Sbjct: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQL---KERCRIEPHTGLLLL 2201

Query: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLD-----KV 1228
            +     M+ +   +    V  L +S  +L   ++ +L+  Q S D   E   D       
Sbjct: 2202 SVQKRSMSFQGIRQ-PVTVTELVDS-GILRPSTVNELESGQISYDEVGERIKDFLQGSSC 2259

Query: 1229 IAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHG 1288
            IAG  ++TT + L +++A+  GL+   T + LLE Q     ++ P       +++A   G
Sbjct: 2260 IAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRG 2319

Query: 1289 LIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGSL 1345
            L+  +   + K LS  + +     P T   I +  A+ + +I +   I++LE  ++TG +
Sbjct: 2320 LVGIEF--KEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGI 2377

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            + P    +L +  A+++   +  L   + +  +  K   DP T E ++ + + +R    E
Sbjct: 2378 IDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDE 2437

Query: 1406 NTGMWLLPVRP-----QEGGRITLK----------CGRNISILRAAHEGLIDRETMFRLL 1450
             TG+ LLP++      Q   + TL+            + +S+  A  +GLID ET   L 
Sbjct: 2438 ETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELC 2497

Query: 1451 SAQL------LSGG-------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGI 1497
              +       ++G        L++  +G +  +++A+ +G++DR         Q ++G +
Sbjct: 2498 EQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFD-----QYRSGSL 2552

Query: 1498 IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITN 1557
              +  A  +++   V       S     + +   +       S     T SS++   I +
Sbjct: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH------ESVSKISTISSVRNLTIRS 2606

Query: 1558 ELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
                  L     IAA++  E+ + I +    + GI+D+ T   L
Sbjct: 2607 SSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRL 2650



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 97/390 (24%), Positives = 164/390 (42%), Gaps = 54/390 (13%)

Query: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN----LLFSESLKQLQESQT 1215
            E+LSE L           D  T+E    L+ + + +++       L   E  KQ+Q SQ 
Sbjct: 2399 EELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQ- 2457

Query: 1216 SGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ-----LMISG- 1269
                  +  L K     +D  T + +SV +A  +GLIDY+T   L E +     + I+G 
Sbjct: 2458 ------KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGS 2511

Query: 1270 -------LISPELRKCFDLKDAKSHGLIDEQI----------LCQLKELSKAKEIISAAS 1312
                   L+  +    +D++DA   GL+D +           L Q  ++   K  +  +S
Sbjct: 2512 DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSS 2571

Query: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372
                 V D +  S   ES++       +ST S V   T              + S+ FS 
Sbjct: 2572 SMGSGVSDDVFSSSRHESVS------KISTISSVRNLT--------------IRSSSFSD 2611

Query: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432
             LE  +    + D    EK+S+ + ++R  +   TG  LL  +   GG I    G+ +S+
Sbjct: 2612 TLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSL 2671

Query: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
              A  +G+ID++   RL  AQ    G       ++M+  EAV+E  +  +     L +Q 
Sbjct: 2672 QDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY 2731

Query: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSA 1522
             TGG++      R++ +EA++   I   +A
Sbjct: 2732 LTGGLVDPEVHGRISTEEAIRKGFIDGRAA 2761



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 93/458 (20%), Positives = 190/458 (41%), Gaps = 67/458 (14%)

Query: 1210 LQESQTSGDVKVE--EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
            ++E+   G V +E  EKL   ++ + G  D  TG ++S+FQA+ + LI+   GIRLLE Q
Sbjct: 2312 VEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ 2371

Query: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALA 1323
            +   G+I P+      +  A   G  +E++   L + S   K      +   +  L    
Sbjct: 2372 IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKE 2431

Query: 1324 QSMITESMAIKVLEIL-----LSTGS----------LVIPATGEQLTLQKAFQQNLVSSA 1368
            + +  E   + +L +      + T            +V P T +++++Q+A+++ L+   
Sbjct: 2432 RCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYE 2491

Query: 1369 LFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTL------QENTGM 1409
             F ++ E++   ++             L+D  T  +  + D + +  +      Q  +G 
Sbjct: 2492 TFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS 2551

Query: 1410 WLLPVRPQEGGRITLKCGRNIS-----------ILRAAHEGLIDRETMFRLLSAQLLSGG 1458
              L    Q    I+LK G   S              + HE +    T+  + +  + S  
Sbjct: 2552 LSLT---QFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSS 2608

Query: 1459 -------------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKR 1505
                         + ++ + +++++ E +  G++D  T   +L  Q  TGGII     ++
Sbjct: 2609 FSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2668

Query: 1506 LTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILN 1565
            L++ +AV   +I    A  +  AQ+ ++G       +    + +++++ +  E   + L 
Sbjct: 2669 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2728

Query: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
             +     L  PE    I  + A + G ID   A  L++
Sbjct: 2729 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQD 2766



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 32/246 (13%)

Query: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESL--KQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235
            D +    R+E   ++ T+    NL    S     L+ES               IA   D 
Sbjct: 2579 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSP-------------IAAIFDT 2625

Query: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295
               E +S+ + + RG++D  TG RLLE Q    G+I P   +   L+DA S G+ID+ + 
Sbjct: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685

Query: 1296 CQLKELSKA---------KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346
             +LK   KA         K+ +SAA        +A+ +  +      + LE    TG LV
Sbjct: 2686 TRLKPAQKAFIGFEGVKGKKKMSAA--------EAVKEKWLPYEAGQRFLEFQYLTGGLV 2737

Query: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406
             P    +++ ++A ++  +      ++ +  +  K L  P T  K+S  D + RS +++ 
Sbjct: 2738 DPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDI 2797

Query: 1407 TGMWLL 1412
            TG+ LL
Sbjct: 2798 TGLRLL 2803


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  316 bits (810), Expect = 2e-85
 Identities = 175/447 (39%), Positives = 281/447 (62%), Gaps = 19/447 (4%)

Query: 1249 RGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEII 1308
            +GL+D DTG+ LLE+Q+++SGLI+PE  +   L++  +  LI+ Q+  QL+EL  A  +I
Sbjct: 3    KGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALI 62

Query: 1309 SAASPTTIP--VLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVS 1366
            S  + +  P  V++A+ + +I+E++ +K+LE  L+TG   +  +   + L++AF Q L+S
Sbjct: 63   SRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLIS 122

Query: 1367 SALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC 1426
            + L S +       K+LIDP T+EK+ L+D++QR  + + +G  LLPV+   GG ++LK 
Sbjct: 123  AWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKS 182

Query: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
            GR +SI RA  EGLIDR+   RLL AQL +GG+++  +G R+TVEEAVR  +ID+D A +
Sbjct: 183  GRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACA 242

Query: 1487 ILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPT 1546
            IL  Q+QTGGII +   +RLT+DEAV  DL+ +  AL++LE+   ++GL+WP SGEI P 
Sbjct: 243  ILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPI 302

Query: 1547 SSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITL 1606
            + +L+Q +++ ELA+KIL+ RQ I AL++P +++++    A + GI+D + A+ LK+I +
Sbjct: 303  TDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICI 362

Query: 1607 PDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLS 1666
            PD MP +                +   S   +      V    +     T+ +++ L L 
Sbjct: 363  PDVMPHM----------------QLADSAEQNINPGAAVLPCSKSHPKATASQSENL-LF 405

Query: 1667 YLMINSYMDANTGQRLLLYDGDLDEAV 1693
             LM +SY++   GQRLLL D +L E +
Sbjct: 406  QLMTHSYINVQNGQRLLLLDKELMETL 432



 Score =  107 bits (267), Expect = 2e-22
 Identities = 75/297 (25%), Positives = 155/297 (52%), Gaps = 7/297 (2%)

Query: 1231 GTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLI 1290
            G ID  +   L+V Q++ RGL++ +  +RLL  Q++  G+I         + +A  HGLI
Sbjct: 908  GLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLI 967

Query: 1291 DEQILCQLKELSKAK--EIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIP 1348
             E +  +LK +      +I +  +   I +  A+   +IT  +  ++ E+   TG+ V  
Sbjct: 968  GEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDL 1027

Query: 1349 ATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTG 1408
             +G++LTL +A ++ L+++    + +    M   ++DP     V   ++V++  +   +G
Sbjct: 1028 ISGQRLTLAEAKKEGLLTN----EAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESG 1083

Query: 1409 MWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRM 1468
               L V P    +  +   + +++ +A   G +D  +  ++L AQ  +GG+I++ +G+R+
Sbjct: 1084 QRYLEVIPFSDIKDGVS-DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRL 1142

Query: 1469 TVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
            T+  A+ E ++D +    I ++QV  GGI+     +R+T+ EA++  LI+   A ++
Sbjct: 1143 TLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMI 1199



 Score =  106 bits (265), Expect = 3e-22
 Identities = 92/397 (23%), Positives = 188/397 (47%), Gaps = 39/397 (9%)

Query: 1204 SESLKQLQESQTSGDVKVEEKL-------DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
            S++ + L   +   +  ++EKL       DK I+G +D  T  + SV  AV  GL+D +T
Sbjct: 778  SQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKET 837

Query: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLI---DEQILCQLKELSKAKE------- 1306
              R+LE Q++  G+I  +  K   +  A + GL+   D+  L  L++ SK ++       
Sbjct: 838  ATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRE 897

Query: 1307 -----------IISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLT 1355
                       +I   S   + V+ ++ + ++    A+++L   +  G ++   +G +L+
Sbjct: 898  RLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLS 957

Query: 1356 LQKAFQQNLVSSALFSKVLERQNM-CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPV 1414
            +  AF+  L+   L  K+   +N+    + +P T E +SL   ++   +  +    +  V
Sbjct: 958  VDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEV 1017

Query: 1415 RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAV 1474
            +   G  + L  G+ +++  A  EGL+  E    +LS  ++  G+++  + + +   E V
Sbjct: 1018 QAFTGNFVDLISGQRLTLAEAKKEGLLTNEA---VLSPGMMH-GIVDPENCRIVPYSELV 1073

Query: 1475 REGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVG 1534
            ++  ID ++    L   +    I      K LT+ +A+Q   +  +S L VLEAQ    G
Sbjct: 1074 KKCKIDIESGQRYLEV-IPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGG 1132

Query: 1535 LIWPHSGEIFPTSSSLQQELITNEL-----AYKILNG 1566
            +I   +G+    +S+L+++L+   +     ++++LNG
Sbjct: 1133 IIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNG 1169



 Score =  104 bits (260), Expect = 1e-21
 Identities = 102/414 (24%), Positives = 194/414 (46%), Gaps = 45/414 (10%)

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERN----ELEKQVKTLQESYN----LLFSESLKQ 1209
            KKE L +       FLAK   K + E +N     +    KT +E       L  S  L+ 
Sbjct: 666  KKEMLKKT------FLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLEL 719

Query: 1210 LQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISG 1269
            L+E+  +  V   + LD    G   + TG+ L + +A+ RG++   T ++L+E   M  G
Sbjct: 720  LEEATLN--VLSAQLLD---GGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQG 774

Query: 1270 LISPELRKCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMIT 1328
                +  +    ++  + GL+DE++L  +    KA   ++   + T   V DA+   ++ 
Sbjct: 775  FFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLD 834

Query: 1329 ESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCT 1388
            +  A ++LE  + TG ++    G+++++  A    LV  A   +++  +   K       
Sbjct: 835  KETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGR----D 890

Query: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
            +EK          T++E     L+ ++ +  G I       ++++++   GL++RE   R
Sbjct: 891  AEK----------TVRER----LISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVR 936

Query: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQ-VQTGGIIQSNPAKRLT 1507
            LL+ Q++ GG+I+  SG R++V+ A R G+I  D A  +   + +    I      + ++
Sbjct: 937  LLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENIS 996

Query: 1508 VDEAVQCDLITSSSALLVLEAQR---GYVGLIWPHSGEIFPTSSSLQQELITNE 1558
            + +A++ DLITS     + E Q     +V LI   SG+    + + ++ L+TNE
Sbjct: 997  LPKAIKLDLITSDLKREIQEVQAFTGNFVDLI---SGQRLTLAEAKKEGLLTNE 1047



 Score = 95.9 bits (237), Expect = 5e-19
 Identities = 97/401 (24%), Positives = 167/401 (41%), Gaps = 42/401 (10%)

Query: 1320 DALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNM 1379
            +A+++ ++    A+K++E L          T E LT ++   + L+   L   VL     
Sbjct: 750  EAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKA 809

Query: 1380 CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEG 1439
               ++DP T    S+ D V    L + T   +L  +   GG I LK G+ +S+  A+  G
Sbjct: 810  ISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLG 869

Query: 1440 LID--------------------RETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
            L+D                    +    RL+S Q+ + GLI+ +S   +TV +++  G++
Sbjct: 870  LVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLL 929

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIW-P 1538
            +R+ A  +LT QV  GGII      RL+VD A +  LI    A  +   +   +  I+ P
Sbjct: 930  EREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNP 989

Query: 1539 HSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
             + E      +++ +LIT++L  +I   +          S Q + L  AK+ G++ N   
Sbjct: 990  ETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEA- 1048

Query: 1599 SILKNITLPDKMPDLGDLEACKNA--RRWLSFCKFQPSTVHDYRQE---EDVFDGEEPVT 1653
                 +  P  M  + D E C+       +  CK    +   Y +     D+ DG     
Sbjct: 1049 -----VLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKV 1103

Query: 1654 TQTSE----------ETKKLFLSYLMINSYMDANTGQRLLL 1684
               S+           T K+  +       +D  TG+RL L
Sbjct: 1104 LTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTL 1144



 Score = 92.0 bits (227), Expect = 8e-18
 Identities = 59/278 (21%), Positives = 135/278 (48%), Gaps = 1/278 (0%)

Query: 1241 LSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKE 1300
            LSV +A+ + +I    G+++LE  L   G        C +L++A   GLI   +   L+ 
Sbjct: 72   LSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLES 131

Query: 1301 -LSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKA 1359
             L  +K +I   +   I +LD + + ++ +    K+L +    G +V   +G ++++ +A
Sbjct: 132  YLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRA 191

Query: 1360 FQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEG 1419
             Q+ L+   +  ++LE Q     ++DP T  ++++ + V+ + + ++    +L  + Q G
Sbjct: 192  VQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTG 251

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
            G I    G+ ++I  A    L+  +    +L +     GL+   SG+ + + +A+ +G++
Sbjct: 252  GIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIV 311

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLI 1517
              + A  IL+ +     +      + L+  +A++  ++
Sbjct: 312  STELAHKILSNRQHIKALFLPATTEILSWKKAIESGIL 349



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 70/285 (24%), Positives = 126/285 (44%), Gaps = 9/285 (3%)

Query: 1227 KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKS 1286
            ++  G +   +G  +S+F+AV  GLID    +RLLE QL   G++ P       +++A  
Sbjct: 172  QLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVR 231

Query: 1287 HGLIDEQILCQ-LKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
            H LID+ + C  L    +   II   +   + + +A++  ++   +A+ +LE L S   L
Sbjct: 232  HNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGL 291

Query: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
            + P +GE L +  A +Q +VS+ L  K+L  +   K L  P T+E +S    ++   L  
Sbjct: 292  LWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDR 351

Query: 1406 NTGMWLLPV-------RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGG 1458
            +    L  +         Q             ++L  +        +    L  QL++  
Sbjct: 352  DLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHS 411

Query: 1459 LINSNSGQR-MTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNP 1502
             IN  +GQR + +++ + E +  RD   +     V+ G   Q  P
Sbjct: 412  YINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTP 456



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 60/294 (20%), Positives = 126/294 (42%), Gaps = 42/294 (14%)

Query: 1199 YNLLFSESLKQLQESQTSGDVK-----VEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
            ++L  SE+   L+E+   G +      V E   +     ID  T E + +   + R ++ 
Sbjct: 101  FSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVH 160

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
             ++G +LL  + +  G++S +  +   +  A   GLID Q+                   
Sbjct: 161  QESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQV------------------- 201

Query: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
                               +++LE  L  G +V P TG +LT+++A + NL+   +   +
Sbjct: 202  ------------------TVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAI 243

Query: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISIL 1433
            L RQ     +ID  T +++++ + V    +     + +L       G +  + G  + I 
Sbjct: 244  LIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPIT 303

Query: 1434 RAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSI 1487
             A  +G++  E   ++LS +     L    + + ++ ++A+  G++DRD A+++
Sbjct: 304  DALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNL 357



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 193/1020 (18%), Positives = 396/1020 (38%), Gaps = 147/1020 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT------------EWGSDLPSVESH 311
            K++LLDQ L+   +  +   ++LNW+ E++ +L               +    L   E  
Sbjct: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            +   KNV +AI+  ++ LK+    E+       L   EKL  ++++YA +  TS    R 
Sbjct: 4048 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 4100

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            L+      ++  +T E +  WL E EEE   +   S     I + +    EL +E+ +  
Sbjct: 4101 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 4160

Query: 427  ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471
              + +V E++  LL L    AR  ++   +    Q+  +              +Q  Q  
Sbjct: 4161 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220

Query: 472  EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
            EQ      A+         A   +R  +D    +    ++ SI    D+++   +  +EL
Sbjct: 4221 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 4275

Query: 532  LQYKSTIANLMGKA-KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590
              ++S I    G+  KT++Q K   ++  ++    I  +   R   +     +   +  N
Sbjct: 4276 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 4327

Query: 591  SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650
                 ++ +SP   E    ++   +P P   A+D   ++ QQ + +  L        +S+
Sbjct: 4328 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 4374

Query: 651  VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
                  I+++ +I       +K + P E + V    Q     +                Q
Sbjct: 4375 AEHKPHIDKLLKIGPQ----LKELNPEEGEMVEEKYQKAENMY---------------AQ 4415

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
            +++EV       Q  L   E   Q   +   +  ++  +   LEN   RL      P E 
Sbjct: 4416 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 4468

Query: 771  DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827
            D + E    I++ +    ELE+L+     +  + EE   ++  +    +   ++ +L+ +
Sbjct: 4469 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4525

Query: 828  LQNMNQVYSMSST----YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
            +     + + +      ++D L+       +  A    +K  +  + + E+   D + I+
Sbjct: 4526 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4585

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
              +   +  + E D        L +EL+  + +  ++     E +      ++  D++  
Sbjct: 4586 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEKPEV--RKSIDEMNN 4636

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001
             W+N++     RL  LE   ++   Y+DT   + DW+   + T  K+    P  +   T+
Sbjct: 4637 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4693

Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055
              QLN+ K    E+  +Q +M++     E         T +D   + +T  + + ++  +
Sbjct: 4694 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4753

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-KK 1114
                R+     A L + +F        + +T   + +    D+ + +  + K +E E  K
Sbjct: 4754 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL----DAQRPISGDPKVIEVELAK 4809

Query: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
             HV K   L         T++   KAG      +  + ++ S+ + +L    Q  +  L 
Sbjct: 4810 HHVLKNDVLAH-----QATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQ 4862

Query: 1175 KHGDKMTDEERNELEKQVKTLQ------ESYNLLFSESLKQLQESQTSGDV--KVEEKLD 1226
            K     T+E   +L+  ++  Q      E + L  +    QL  S+ +G +     E+LD
Sbjct: 4863 K-----TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4917



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 196/1100 (17%), Positives = 415/1100 (37%), Gaps = 211/1100 (19%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 305
            +SSLL + + + +   + ++ LL  + E++  L+  +  S                  D+
Sbjct: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597

Query: 306  PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 360
               +S LE   + V R +E  +S+   + + K++E+ Q    L L   EK    ES   K
Sbjct: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LL  +   E     L  F+   +  L   N+ +++   +    +  N+            
Sbjct: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            E++ ++EN+ +++ +  +L                   +   + L LCQ  ++       
Sbjct: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
                 N  K+ T+  + +K+  +   SC ++     KL    Q+ ++E E  +    T  
Sbjct: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792

Query: 540  NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 599
            +     K I  LK    D   K ++  +  C    +E  I +    + A +S      ++
Sbjct: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848

Query: 600  SPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW----HY 655
               G+     +   T     +   D+++ +  +Y+ +  + HE   +++++++     H 
Sbjct: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSD-VNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907

Query: 656  LINEIDRIRASNVASIKTM----LPGEHQQVLSNLQSRFEDFLEDSQES-------QVFS 704
              N + +   S    +K+M     P + + V +  +S      E  Q S       +  +
Sbjct: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967

Query: 705  GSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRLE 754
            G  +T    +     +  QE L S          A + + EES  +L   +    +LR  
Sbjct: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 3027

Query: 755  NCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEEF 807
              E  L+  +  PL  D         +  F + E E  +++ E+L +   G +T   +  
Sbjct: 3028 LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVS 3087

Query: 808  FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYET 867
             S +     + ++  +   +   +N      S+ ID+      ++K+TQ  E L      
Sbjct: 3088 LSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL-----Q 3133

Query: 868  KLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 923
             L E+   +  + ++++ IST    +KQ   E  E R     L+ E+++A+ + DE+   
Sbjct: 3134 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 3193

Query: 924  YKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ-- 981
              E+ L  D  K++ + +    Q +     +R+  L+    S + ++  +  L  W+   
Sbjct: 3194 IGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 3252

Query: 982  ------------QVETTQRKIQENQP-----------------------------ENSKT 1000
                        ++E  Q ++QEN+                              E  +T
Sbjct: 3253 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 3312

Query: 1001 LATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKD------------------ 1038
            L  QL + K    E+  K    QS++ +C + A++Y   V+D                  
Sbjct: 3313 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 3372

Query: 1039 -----YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093
                  E   +  +AM++  +K       + S+AD++I                + Q + 
Sbjct: 3373 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 3432

Query: 1094 FAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1153
               + L+      + + +  +E  E  K ++K V      L+  +  G    S + +  E
Sbjct: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL--E 3490

Query: 1154 EISTKKEQLSEALQTIQLFLAKHGDKMTDE-----ERNELEKQVKTLQESYNLLFSESLK 1208
            ++  ++E L +AL+    +L      + ++     + ++L  Q +  Q+ +         
Sbjct: 3491 KLRAQQEVL-QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF--------L 3541

Query: 1209 QLQESQTSGDVKVEEKLDKV 1228
            ++++   SG V +E KL+ +
Sbjct: 3542 EVKQRVNSGCVMMENKLEGI 3561



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 188/1017 (18%), Positives = 387/1017 (38%), Gaps = 155/1017 (15%)

Query: 259  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 305
            ++ L+K+    QN   +++     +DL +WV + +  L     RT            SDL
Sbjct: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094

Query: 306  PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 362
              ++  ++N   +    +++ E  ++E   K+S  ++TA       EKLH+ + QY  L 
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149

Query: 363  NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 422
              +R  ++ L+     V+ A  +     E E+ + A + +E    I    D+   +    
Sbjct: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201

Query: 423  DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 482
             Q   N+  +++++   L +   A  T + Y    Q       Q C+ ++   +E  +  
Sbjct: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258

Query: 483  EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
            + F                N   E    L+     ++ +YS   + S  +L+  VQ   +
Sbjct: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317

Query: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
            E ++ LQ      + + +++  ++   +    P      +K    + +  I         
Sbjct: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 642
                SH+   + ++ +G + +     F      KE  ++ N ++ + ++     T  H  
Sbjct: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421

Query: 643  -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 687
                 SH+NM  +  +H   N  D ++A   +  A+++ +L       PG  Q+ L+  +
Sbjct: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480

Query: 688  SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 733
               E+  E     +       DI ++E E     ++ QE   S            AER  
Sbjct: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540

Query: 734  -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 786
                   Q +SV     S +++I    +N E + +  + + + ++ L  ++       KL
Sbjct: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593

Query: 787  KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 846
            K+++ R K  L   T +    F + A S++   L+ +L  V Q   Q+        +K  
Sbjct: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649

Query: 847  TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 902
            ++  +L   +  E L    +  +  +  ++A  N    +I +    +++   E++++++ 
Sbjct: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709

Query: 903  FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 962
               LE  + +  +             LD   H+++   L + +  +   +  R +D    
Sbjct: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760

Query: 963  GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
             + L  +R        W+++ E        +   K  E Q E+ K+L      +  LV E
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
            I  K + ++           T  D + +T +    V S   S V           I  + 
Sbjct: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVEKAKELQKWVSN 1129
             D+  +Y  L  ++ +  +     L R+EE  K         E KE V K+ +     + 
Sbjct: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934

Query: 1130 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186
             ++T+K   ++ K   ++ + +S +I   KE L+  L T          K   EE N
Sbjct: 2935 -TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELN 2990



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 41/168 (24%), Positives = 76/168 (45%), Gaps = 1/168 (0%)

Query: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
            GR I  L  +H   +  E    +LSAQLL GG+ +  +GQ++ + EA+  G++   TA  
Sbjct: 706  GREI-FLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK 764

Query: 1487 ILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPT 1546
            ++       G   S   + LT +E +   L+       VL A +   G++ P +  +   
Sbjct: 765  LMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSV 824

Query: 1547 SSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIID 1594
              ++   L+  E A +IL  +     +   +  + + +  A  LG++D
Sbjct: 825  KDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVD 872



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 201/1075 (18%), Positives = 403/1075 (37%), Gaps = 199/1075 (18%)

Query: 282  VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
            +Q + +W+D   ++L      G+DL +V+  L   K     +E ++  ++  K++     
Sbjct: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723

Query: 341  APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
               K T             E  H  E+   K+ +     E  L  L  F       + WL
Sbjct: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783

Query: 390  NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
               EE       ++ D       +A+    H  L  ++   +  +++V +   +LL  + 
Sbjct: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839

Query: 445  -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
                 ++ +   AM   W  +LQ  +  EQ ++      + F+   E  D+L  L    +
Sbjct: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894

Query: 504  RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
             +     S     L +  +E ++   EL       + T   L+ K + ++ L   +S   
Sbjct: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953

Query: 560  LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
             KT   +  +                         KW V+S    E              
Sbjct: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981

Query: 620  KEAVDLANRIE---QQYQNVLTLWHESHINMKSVVSW--HYLINEIDR-------IRASN 667
            +EA++LA   +   Q++ N LTL  +S +N+ S  S   + ++++I+        + A  
Sbjct: 4982 EEALNLATEFQNSLQEFINWLTLAEQS-LNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040

Query: 668  VASIKTMLPGEHQQVLS-------------NLQSRFEDFLEDSQESQVFSGSDITQLEKE 714
               I+    G   + LS             ++QSR+E  ++ S E     G  +    K 
Sbjct: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKR 5096

Query: 715  VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE----- 769
                KQ+++   K  +  E  ES  +          L + N  D++  Q+    E     
Sbjct: 5097 A---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTL 5145

Query: 770  --RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 823
              +  ++++  R    + E+  L ++ ++L + LG + +K +    ++            
Sbjct: 5146 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ-------- 5197

Query: 824  LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
                   + +    S  ++D L+ +          + L K+ E +L E++ V  D + + 
Sbjct: 5198 -----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVM 5242

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
            NL+   K ++ E+ ++      L       K    E+ +  ++   D  W K +  +L  
Sbjct: 5243 NLMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELST 5292

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLAT 1003
            RW  V     ++   LE   K  + +RDT H L +W+ + E T R  +   P++++ L +
Sbjct: 5293 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQS 5351

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------ 1052
             ++  K  + ++E K+  ++      E   A      + T+ +     RA  +       
Sbjct: 5352 LIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAK 5411

Query: 1053 --QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1110
              QQ+       + ++A+L+ +    ++   T L+    + I    D +K L  E ++  
Sbjct: 5412 QHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFM 5471

Query: 1111 EE---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIS 1156
            EE   K+  V++  +  K   NI  T    ++ +   G+       PP       SE  +
Sbjct: 5472 EEMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5530

Query: 1157 TKKEQLSEALQTIQLFLAKHGDKMTD-----EERNEL---------EKQVKTLQESYNLL 1202
             +  QLS   Q + L   +   K+ D     EE  E          +K ++ +    + +
Sbjct: 5531 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRV 5590

Query: 1203 FSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGE---VLSVFQAVLRGLIDY 1254
              +  +++ + Q  G +  +E +D ++A     T  E   V  +F     G IDY
Sbjct: 5591 M-DFFRRIDKDQ-DGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY 5643



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 192/1080 (17%), Positives = 404/1080 (37%), Gaps = 202/1080 (18%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLP-SVESHLENHKNVHRAI 322
            +SS +DQ + +     + +QDL   V  +  +L      S  P +V+  LE    +   +
Sbjct: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173

Query: 323  EEFESSLKEAK---------ISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQER 370
            E+ +  +KEA+         I E  +   LK    T A  L  LE   A  +N     + 
Sbjct: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN---RLQA 3230

Query: 371  HLDTLHNFVSRATNELIWLNEKEEEEVAY-DWSERNTNIARKKDYHAELMRELDQKEENI 429
             L +   F         WL++K+ ++      S +   +  +   + E  + L+Q   + 
Sbjct: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290

Query: 430  KSVQEIAEQLLLENHPA--RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
            + +    E LLL   P   + T++     ++  W  +                       
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL----------------------- 3327

Query: 488  AKEATDYLRNLKDAIQR--KYSCDRSSSIHKLEDLVQESME--------EKEELLQYKST 537
            +K+  D    LKD +Q+  KY       +  +ED   +  E        + E  L     
Sbjct: 3328 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 3387

Query: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
            + N + K ++++++    +D  + +S          + +    +D++  +  N      +
Sbjct: 3388 MLNEVEKRRSLLEILNSAADILINSS----------EADEDGIRDEKAGINQNMDAVTEE 3437

Query: 598  VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
            + + TG+               +E        ++ ++N+           K V    + +
Sbjct: 3438 LQAKTGSL--------------EEMTQRLREFQESFKNI----------EKKVEGAKHQL 3473

Query: 658  NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS---GSDITQLEKE 714
               D + +   ++         Q+VL  L+ +  D+L +  +  V     GSD +QL  +
Sbjct: 3474 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQGLVEDAPDGSDASQLLHQ 3532

Query: 715  VNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNIRLRLENCEDRL--------- 760
              V +Q + E+ +         E + E +   +   VR +  +L + +D L         
Sbjct: 3533 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC-RVREMFSQLADLDDELDGMGAIGRD 3591

Query: 761  -------IRQIRTPLERD-------DLHESVFRITEQEKLKKELERLKDDLGTITNKCEE 806
                   I  +R  L +        +  E+  R   +E+   +L  LK +L  +  +C +
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651

Query: 807  FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
               +  A       + +L + L  +   Y        KLK +N      + AEAL  +  
Sbjct: 3652 LTERGKAR------QEQLELTLGRVEDFYR-------KLKGLNDATTAAEEAEALQWVVG 3698

Query: 867  TKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE 926
            T++      +AD                ++ +K QV   L+ +LQ+   +   + ++   
Sbjct: 3699 TEVEIINQQLAD---------------FKMFQKEQV-DPLQMKLQQVNGLGQGLIQS-AG 3741

Query: 927  RDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
            +D D    +   +++  RW  ++ ++  R+  L+        ++D   PL  W+     T
Sbjct: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD---T 3798

Query: 987  QRKIQENQPENS--KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQ 1042
            +  I   +P ++  K +  Q+ +QK+L   ++ +++ +D  Q    +   SA + D E  
Sbjct: 3799 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858

Query: 1043 TMTYRAM----VDSQQKSPVKRRRMQSSADLIIQ--EFMDLRTRYTALVTLMTQYIKFAG 1096
            T    ++     +   K+  ++++++    L  Q  E  +  + + ++        +  G
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918

Query: 1097 DSLKRLEEE---EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152
                +++++    K+LEE+ + H     +  K   ++S     AE+        +KI S 
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG----VLSEKIDSL 3974

Query: 1153 --------EEISTKKEQLSEALQTIQLF----------LAKHGDKMTDEERNELEKQVKT 1194
                    +    K   L +AL   +LF          LA+  DK++     + ++ V  
Sbjct: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 4034

Query: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVI---AGTIDQTTGEVLSVFQAVLRGL 1251
             Q + +L  +E +           V  ++ +D+ I      + QTTGE + + Q  L G+
Sbjct: 4035 RQHADHLALNEEI-----------VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 108/547 (19%), Positives = 223/547 (40%), Gaps = 95/547 (17%)

Query: 733  EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELER 792
            E +E + + Y+S +RNI +R +  +         PLE + L E    + + + L++EL+ 
Sbjct: 1805 EHDEKLVS-YLSLLRNIEMRTKQIQ---------PLELN-LAELQDLLCQAKVLERELK- 1852

Query: 793  LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVL 852
               DL T+ ++  E  +Q   S         L  + ++   +    S+  D   +  L  
Sbjct: 1853 ---DLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHF 1909

Query: 853  KNTQAAEALVKL-----YETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR-----QV 902
            +N    E    L      E +L +  A + +KN    LI   K   SE+D        Q 
Sbjct: 1910 QNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKN----LILNSKGSNSEIDVDSLNLCLQQ 1965

Query: 903  FHALEDELQKAKAISD------EMFKTYKERDLDFDWHKEKA---DQLVERWQNVHVQID 953
            +  L+  + + KA  D      + F +   +DL    +++     ++L   +Q++  Q  
Sbjct: 1966 YEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTA 2025

Query: 954  NRLRDLEG---------IGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLAT 1003
             ++  L+G         + K+L+  ++T H  L+D    V   +R +  +Q   ++   +
Sbjct: 2026 AQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLS 2085

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRM 1063
             L + +  + +++      D+ Q  A  ++  VKD E      +  +  ++ + ++ +  
Sbjct: 2086 ALQKNQSDLKDLQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLH 2139

Query: 1064 QSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL 1123
            Q+       E +   TR      +  + ++ A  S  + E E+    +E  E+ +K   L
Sbjct: 2140 QAKEQY---EALQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 2190

Query: 1124 QKWVSNISKT-------LKDAEKAGKPPFSK-------------------------QKIS 1151
              WV+++  +       L   E+       K                          K  
Sbjct: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250

Query: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQ 1211
             +E+ ++++    A Q+ Q FL +HG  +T EE+  L++++  L+E Y+   ++S  +L+
Sbjct: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310

Query: 1212 ESQTSGD 1218
            + QT  D
Sbjct: 2311 QVQTLQD 2317



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 139/730 (19%), Positives = 286/730 (39%), Gaps = 158/730 (21%)

Query: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVCKQYYQELLKS 728
            KT +  +H Q    L+ R +D         +   S  +  E +V   N+C Q Y++L + 
Sbjct: 1917 KTKVLNQHTQ----LEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQP 1972

Query: 729  -AEREEQEESV---YNLYISE--------VRNIRLRLENCEDRLIRQI--RTPLERDDLH 774
             AER+ Q +++      +ISE             LRL N   R  + I  +T  + D L 
Sbjct: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032

Query: 775  ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFS------QAAASSSVPTLRSELNVVL 828
              + ++ EQE L K L++ ++   T   + E+  S      +A A     T + +L+ + 
Sbjct: 2033 GHLQQM-EQEALVKTLQKQQN---TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQ 2088

Query: 829  QNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST 888
            +N + +  +     ++  +   V+K+    E  ++  +TKL   E               
Sbjct: 2089 KNQSDLKDLQDDIQNRATSFATVVKDI---EGFMEENQTKLSPRE--------------- 2130

Query: 889  LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
            L   R ++ + ++ + AL++E + A+   +E   +  +++ +    K KA          
Sbjct: 2131 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE----KSKA---------- 2176

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
                           K L   +     L DW+  V ++  ++  N P   +     L + 
Sbjct: 2177 --------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222

Query: 1009 KMLVSE----IEMKQSKMD-ECQKYAEQYSATV---KDYELQTMTYRAMVDSQ--QKSPV 1058
             +  ++    +     K+D +C+    ++   +   +++ L T + +A +D      +P 
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1118
            +++ +Q       Q+  +L+ +Y+  +      +K           + ++L++E ++ ++
Sbjct: 2283 EQQMLQ-------QKLGELKEQYSTSLAQSEAELK-----------QVQTLQDELQKFLQ 2324

Query: 1119 KAKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQLF 1172
              KE + W+    K L++  K G  P        +Q   SE++ + K  L         F
Sbjct: 2325 DHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLR--------F 2376

Query: 1173 LAKHGDKMTDEER------------NELEKQVKTLQESYNLLFSES----------LKQL 1210
            +   G K+ D E             N ++ ++K   E Y  L S+           L Q 
Sbjct: 2377 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQY 2436

Query: 1211 QESQTSGD------VKVEEKLDKVIAGTIDQTTG---EVLSVFQAVLRGLIDYDTGIRLL 1261
             + Q S D         E  ++K+++ T+    G   E L+  + +   L ++   +  L
Sbjct: 2437 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496

Query: 1262 ETQ----LMISGLISPELRKCFDLKDA-KSHGLIDEQILCQLKELSKAKEIISAASPTTI 1316
            +      + I G  +P+ R   +  D+  SH    + +   L E S   +   A S +  
Sbjct: 2497 QKVARDIMEIEGEPAPDHRHVQETTDSILSH---FQSLSYSLAERSSLLQKAIAQSQSVQ 2553

Query: 1317 PVLDALAQSM 1326
              L++L QS+
Sbjct: 2554 ESLESLLQSI 2563



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 63/304 (20%), Positives = 135/304 (44%), Gaps = 38/304 (12%)

Query: 1324 QSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAF-----------QQNLVS-SALFS 1371
            Q  + +++ IK LE+   T   V P   +++ L+K F            QN+   S + S
Sbjct: 640  QVQVKKTLGIK-LELKSETDGNVHPLDKKEM-LKKTFLAKDDHKESQEAQNIAGGSMMMS 697

Query: 1372 KVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNIS 1431
            +  + ++  +++   C+      +++++ +TL       +L  +  +GG    + G+ + 
Sbjct: 698  EKTDEEDSGREIFLSCSHP----LELLEEATLN------VLSAQLLDGGIFHEQTGQKLL 747

Query: 1432 ILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQ 1491
            +  A   G++   T  +L+    +  G  +S + + +T EE + EG++D     ++L   
Sbjct: 748  LNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMAD 807

Query: 1492 VQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG-EIFPTSSSL 1550
                G++        +V +AV   L+   +A  +LE Q    G+I    G ++  T +S 
Sbjct: 808  KAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLAST 867

Query: 1551 --------QQELITNELAYKILNG----RQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
                    Q ELI  E A K  +     R+++ +L + E++ +I  D+   L ++ +   
Sbjct: 868  LGLVDVADQPELINLEKASKGRDAEKTVRERLISLQM-ETTGLIDPDSKAPLTVVQSIDR 926

Query: 1599 SILK 1602
             +L+
Sbjct: 927  GLLE 930



 Score = 39.3 bits (90), Expect = 0.060
 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
            K S L+Q L + E+    V  LL W+ E +  L  R     D  +++S ++ HK   + +
Sbjct: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363

Query: 323  EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
            EE    +  A  + E+ +         T    +  + +++ ++L  ++  ++ L+T L  
Sbjct: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423

Query: 378  FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
             V+ A      L W+   E   +  D      NI R K     H   M E+ +K+ ++  
Sbjct: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483

Query: 432  VQEIAEQLLLE 442
            V +  ++  +E
Sbjct: 5484 VTKTYKRKNIE 5494



 Score = 37.7 bits (86), Expect = 0.18
 Identities = 99/503 (19%), Positives = 204/503 (40%), Gaps = 69/503 (13%)

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
            T+  K+++++ R K     I N   +         S+ +L S  E  V+ + ++ + +  
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3978

Query: 839  STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
            S   D+      +L    +   L    E ++    A + DK     L S  +K ++ +V 
Sbjct: 3979 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 4033

Query: 898  EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
             ++   H AL +E+   K   D+  K        T  E  L     +EK D +  R+ ++
Sbjct: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 4090

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE----------TTQRKIQENQPENS 998
             V     LR LE   +    ++ TY  L  W+++VE           T  +I + Q +  
Sbjct: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ-QRQ 4149

Query: 999  KTLATQLNQQKMLVSEI-EMKQSKMDECQKYAEQ-----YSATVKDYELQTMTYRAMVDS 1052
            K L  ++ + ++++  + E+ ++ ++     A +      S   + Y+L + T    VD 
Sbjct: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209

Query: 1053 QQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---------VTLMTQYIK-FAGDSLKRL 1102
               +  + ++ + +AD  +    + + +  AL          T   Q  K F+ D ++  
Sbjct: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 4269

Query: 1103 EEEEKSL-----------EEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1151
            +  ++             EE+K    EK + L +    IS  L ++E+  +    + ++ 
Sbjct: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS--LLNSERYAR--LERAQVL 4325

Query: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER-NELEKQVKTLQES---YNLLFSESL 1207
              +     E+LS  ++  +  +A+      D E+  + +++++ L+ES   +     + L
Sbjct: 4326 VNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 4385

Query: 1208 K---QLQESQTSGDVKVEEKLDK 1227
            K   QL+E        VEEK  K
Sbjct: 4386 KIGPQLKELNPEEGEMVEEKYQK 4408



 Score = 36.2 bits (82), Expect = 0.51
 Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)

Query: 279  MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
            M  +Q L++W+ +++ QL  D+   G DL  V + ++ HK   + + +   +++  K S 
Sbjct: 5211 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269

Query: 336  -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
             E+   +    T+ + +L  L +++  +   S +++  L+       V R T  ++  WL
Sbjct: 5270 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 5329

Query: 390  NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
            +E E+          +T   +   D H E M+++++K  ++ S   + E +L   HP  +
Sbjct: 5330 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 5389

Query: 449  T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
            T     I   RA  +   +W  Q  Q +E  + E  A  E   +
Sbjct: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 5433


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  283 bits (723), Expect = 2e-75
 Identities = 227/944 (24%), Positives = 435/944 (46%), Gaps = 108/944 (11%)

Query: 279  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186

Query: 336  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235

Query: 396  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528

Query: 755  NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579

Query: 814  SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639

Query: 874  AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699

Query: 934  HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755

Query: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815

Query: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1107
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875

Query: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q  +   
Sbjct: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQ 1211
              +  L K  D + +E   +L++ +   Q   N L  E L+ LQ
Sbjct: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHK-NQLLQEELEALQ 975



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 201/1026 (19%), Positives = 402/1026 (39%), Gaps = 167/1026 (16%)

Query: 305  LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNT 364
            L  +E+ L+N KN+   I   E  +++   +  Q    +K  Y  +  +L S    LL+ 
Sbjct: 760  LSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVK-DYELEAEKLRS----LLDL 814

Query: 365  SRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ 424
               +  H+       S AT       ++EE  +A  ++E    I R++  + E    L +
Sbjct: 815  ENGRSSHVSKRARLQSPATKV-----KEEEAALAAKFTEVYA-INRQRLQNLEFALNLLR 868

Query: 425  KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEF 484
            ++  +    E+  + L  N P     EA++   +                 +E     + 
Sbjct: 869  QQPEV----EVTHETLQRNRPDSGVEEAWKIRKELD---------------EETERRRQL 909

Query: 485  FNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED-LVQESMEE----------KEELLQ 533
             N+ K   + +  L++   ++ S  R   + K+ D +++ES ++          K +LLQ
Sbjct: 910  ENEVKSTQEEIWTLRNQGPQE-SVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQ 968

Query: 534  YKSTIANLMGKA--------------KTIIQLKP--RNSDCPLKTSIPIKAICDY---RQ 574
             +     L  +A              K +++++P    +D  L+    ++A+      R+
Sbjct: 969  EELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGARE 1028

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN--RIEQQ 632
             E+ + +     LA    RA+ KV                     KE V L N  ++E +
Sbjct: 1029 AEVLLLQQRVAALAEEKSRAQEKVTE-------------------KEVVKLQNDPQLEAE 1069

Query: 633  YQNVLT-LWHESHINMKSVVSWHYLINEIDRIR-----ASNVASIKTMLPGEH----QQV 682
            YQ +      +  +  K      +L +++ R+      A    ++K +L  E     ++ 
Sbjct: 1070 YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATERE 1129

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV-----NVCKQYYQELLKSAEREEQ--E 735
            +S+L  ++ED    ++ SQ     + T+L +++        K   QE ++   R +   E
Sbjct: 1130 VSDLTRQYEDEAAKARASQ----REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAE 1185

Query: 736  ESVYNLYISEVRNIR--------LRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLK 787
              V NL +  V   R        LR    E   +R+    +E  ++ + V +     +++
Sbjct: 1186 SEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEME 1245

Query: 788  KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 847
            KEL+RL++++   T   E           +  L+ E+  +     QV +      + ++ 
Sbjct: 1246 KELQRLREEIVDKTRLIER------CDLEIYQLKKEIQALKDTKPQVQTK-----EVVQE 1294

Query: 848  VNLVLKNTQAAEALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEK---R 900
            +    ++ Q  E +  L   KL EE+    D    + + E  I+  ++  S V E+   +
Sbjct: 1295 ILQFQEDPQTKEEVASL-RAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQ 1353

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            +V    E+   +A+A +       + R +D    K +A+  + R Q    +++ +L +LE
Sbjct: 1354 EVVRYEEEPGLRAEASAFAESIDVELRQID----KLRAE--LRRLQRRRTELERQLEELE 1407

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
               ++ +        L   +  +E  + + +E      K +  Q  QQ         ++ 
Sbjct: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQ--------AREH 1459

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
             +   Q   EQ+   + + EL+T+  R  + + +K+ VK +       +++ E + +   
Sbjct: 1460 ALLRLQLEEEQHRRQLLEGELETL--RRKLAALEKAEVKEK-------VVLSESVQVEKG 1510

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD-AEK 1139
             T       Q I+    SL+     ++ L+ E      +  EL+   S  SK L    E+
Sbjct: 1511 DT------EQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREE 1564

Query: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN--ELEKQ---VKT 1194
              K    +Q +  E    + E    A +T  L      D  T+ +     LE++   +K 
Sbjct: 1565 NHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKR 1624

Query: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDY 1254
            L +  +L   E  K+L       + + E  L + I   I   TG  LS  +A   GLID+
Sbjct: 1625 LSKDKDLEIDELQKRLGSVAVKREQR-ENHLRRSIV-VIHPDTGRELSPEEAHRAGLIDW 1682

Query: 1255 DTGIRL 1260
            +  ++L
Sbjct: 1683 NMFVKL 1688



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 138/713 (19%), Positives = 281/713 (39%), Gaps = 129/713 (18%)

Query: 620  KEAVDLANRIEQQYQNV--LTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTM--- 674
            +E VD+ANR+E+  Q    L   HE+H+N    V       E  R+  S    +  M   
Sbjct: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP------ESSRVLDSKGQELAAMACE 661

Query: 675  ------LPGEHQQVL-------SNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY 721
                  L GE +Q L       S L SRF++   D +  +    +++ +L +  N  +Q 
Sbjct: 662  LQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQE----AEVHKLGQRFNNLRQQ 717

Query: 722  YQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRIT 781
             +   +S +  +     ++     V    + + + E         P E D L +   ++ 
Sbjct: 718  VERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYE---------PQETDSLSQMETKLK 768

Query: 782  EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
             Q+ L  E+   + ++  I    +++  QA     +   +      L+++  + +  S++
Sbjct: 769  NQKNLLDEIASREQEVQKICANSQQY-QQAVKDYELEAEK------LRSLLDLENGRSSH 821

Query: 842  IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK------------NNIENLISTL 889
            + K               A ++   TK+ EEEA +A K             N+E  ++ L
Sbjct: 822  VSK--------------RARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867

Query: 890  KQWRSEVDEKRQVFHALEDELQKAKAIS--DEMFKTYKERDLDFDWHKEKADQLVERWQN 947
            +Q + EV+          + LQ+ +  S  +E +K  KE D + +  ++  +++    + 
Sbjct: 868  RQ-QPEVE-------VTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919

Query: 948  VHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ-ENQ--PENSKTLATQ 1004
            +    +   ++     + LK   D    L++  QQ++ T  + Q +NQ   E  + L  Q
Sbjct: 920  IWTLRNQGPQESVVRKEVLKKVPDPV--LEESFQQLQRTLAEEQHKNQLLQEELEALQLQ 977

Query: 1005 LNQ---------QKMLVSE---IEMKQSKMDECQKYAEQYSAT-----VKDYELQTMTYR 1047
            L           Q+ +V E   IE  +++ DE  +  E+  A       ++ E+  +  R
Sbjct: 978  LRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037

Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEK 1107
                +++KS  + +  +    + +Q    L   Y  L     Q      D L+  +EEE 
Sbjct: 1038 VAALAEEKSRAQEKVTEKEV-VKLQNDPQLEAEYQQL-----QEDHQRQDQLREKQEEEL 1091

Query: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
            S  ++K + +EK + + +    + + LK           K   +  E+S    Q  +   
Sbjct: 1092 SFLQDKLKRLEKERAMAEGKITVKEVLK---------VEKDAATEREVSDLTRQYEDEAA 1142

Query: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTL-QESYNLLFSESLKQLQESQTSGDVKVEE-KL 1225
                       + +  E+ EL +++  L +E+  ++  E ++++       + +V   +L
Sbjct: 1143 KA---------RASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLE-TQLMISGLISPELRK 1277
            + V      +   E L  +Q+ L  L      + + E T+ +I     PE+ K
Sbjct: 1194 ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEK 1246


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  190 bits (483), Expect = 2e-47
 Identities = 178/850 (20%), Positives = 355/850 (41%), Gaps = 90/850 (10%)

Query: 289  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 348
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206

Query: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261

Query: 409  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321

Query: 468  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 527
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381

Query: 528  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439

Query: 588  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481

Query: 648  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 482  -----------------ASELQALKQKL----ATVQSRLKASAVESLRPSQQAP--SGSD 518

Query: 708  ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552

Query: 768  LER-DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672

Query: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732

Query: 947  NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788

Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1065
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848

Query: 1066 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1125
              + I  +  +L   YT +     Q ++    + K LE++E S +  +    ++  E   
Sbjct: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPA 908

Query: 1126 WVSNISKTLK 1135
                 S+ LK
Sbjct: 909  QAGRESEALK 918



 Score =  102 bits (254), Expect = 6e-21
 Identities = 244/1286 (18%), Positives = 501/1286 (38%), Gaps = 198/1286 (15%)

Query: 374  TLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 433
            T   F +   N   WL      +V    S+  + IA K      L +E+  +E +  +  
Sbjct: 751  TYQQFKNCKDNLSSWLEHLPRSQVRP--SDGPSQIAYKLQAQKRLTQEIQSRERDRATAS 808

Query: 434  EIAEQLLLENHPARLTIEAYRAAMQTQWSW----------ILQLCQCVEQHIKENTAYFE 483
             +++ L        L  + YR +++   +           + +  Q  E+++ +  AY E
Sbjct: 809  HLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAK--AYTE 866

Query: 484  FFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMG 543
                 ++    L   +  +++K   + S  I +  D  Q S    +   + ++  A L  
Sbjct: 867  VAAAQQQLLQQLEFARKMLEKK---ELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEE 923

Query: 544  KAKTIIQLK-----PRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKV 598
            + K + +++      R+    L+T  P++ + +   +E   Y+D +              
Sbjct: 924  ERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEF--YRDPQL------------- 968

Query: 599  ISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLIN 658
                  E  +  V   V    K    L   +E   Q V+ L  +     +  +  H L  
Sbjct: 969  ------EGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESK-----RKTMQPHLLTK 1017

Query: 659  EIDRIRA-----SNVASIKTM---LPGEHQQVLSNLQSRFEDFLE------DSQESQVFS 704
            E+ ++       S  A ++     L GE   + + L+   ++ L       D +E  V  
Sbjct: 1018 EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVK 1077

Query: 705  GSDITQLEKEVNVCKQYYQELLK----SAEREEQEESVYNLYISEVRNIRLRLENCEDRL 760
              ++ ++EK + + K      L+    +A R++ EE+V  L  + + ++   + + E ++
Sbjct: 1078 --EVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQ-ARIEDLERAISSVEPKV 1134

Query: 761  I-----------------RQIRTPLERD------------DLHESVFRITEQEKLKKELE 791
            I                  ++R+ LE +            DLH S + + E+++ K +L+
Sbjct: 1135 IVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLH-SKYSVVEKQRPKVQLQ 1193

Query: 792  RLKDDLGTITNKCEEFFSQAAA-----SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 846
                ++  +  + E+  ++  A     +     +  E+  +L ++  + +   T ++  +
Sbjct: 1194 ERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPT-VEYKE 1252

Query: 847  TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI---STLKQWRSE-------- 895
                V+++ ++ E L ++   K    E V +   + E LI       +WR E        
Sbjct: 1253 VTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKT 1312

Query: 896  --------------VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
                            E  ++   + +  QK +A  D +++   +R L     + K ++ 
Sbjct: 1313 VSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLL---LERRKPEEK 1369

Query: 942  VERWQNVHVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVET---TQRKIQENQPEN 997
            V   + V  Q D +LR+    +  SL         L+  +QQ+      Q  +   Q + 
Sbjct: 1370 VVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDR 1429

Query: 998  SKTLATQ--LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQ 1054
            SK LA +  L Q  + + E+E +   + E +   E+     KD +L+  T     D  Q+
Sbjct: 1430 SKKLAVERELRQLTLRIQELEKRPPTVQE-KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488

Query: 1055 KSPVKR-----RRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEE 1104
            K+ V       + +Q   D++ +     +T Y  ++ +    +         + L R   
Sbjct: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERT 1548

Query: 1105 EEKSLEEEKK---EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ 1161
              ++ EEE +   E +++A+ L +  S     L+ A         + +     +  +K+Q
Sbjct: 1549 ARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQ 1608

Query: 1162 -----------LSEALQTIQLFLAKHGDKMTD------EERNELEKQVKTLQESYNLLFS 1204
                       LS+  ++ +   A+ G +++        E++++ ++ +TL++ +  +  
Sbjct: 1609 QTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668

Query: 1205 ESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
            E L Q  E+QT      E  L   I+  ++  TG+ +S ++A  RG+ID    ++L E +
Sbjct: 1669 EELSQ--ETQTR-----ETNLSTKIS-ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELE 1720

Query: 1265 -----LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVL 1319
                 +  SG    E     D K  K +  I+  + C  + +SK +  +       I   
Sbjct: 1721 CDWEEVTTSGPCGEE-SVLLDRKSGKQYS-IEAALRC--RRISKEEYHLYKDGHLPISEF 1776

Query: 1320 DALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNM 1379
              L       S ++ +  I+ S   L  PA         +F   L   +           
Sbjct: 1777 ALLVAGETKPSSSLSIGSII-SKSPLASPAPQSTSFFSPSFSLGLGDDSF---------P 1826

Query: 1380 CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEG 1439
               + D  T  K S+   V ++ L   TG  LL  +   GG + L      S+ +A   G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886

Query: 1440 LIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQ 1499
            LI+  +  RLL+AQ    G+ +  + +R++V EAV++G + R++    L  Q  TGG+I 
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946

Query: 1500 SNPAKRLTVDEAVQCDLITSSSALLV 1525
                 R+ + +A+   +I+   A L+
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLL 1972



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 170/798 (21%), Positives = 327/798 (40%), Gaps = 91/798 (11%)

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS-DITQLEKE 714
            ++ EIDR++A     + +   G  Q+ L  LQ   +++  +  + +  + S ++ + EK+
Sbjct: 1266 VLREIDRLKAQLNELVNSH--GRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKD 1323

Query: 715  VNVCKQ---YYQELLKSAE-REEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
              + K+     QE+ ++A+ R   E++VY L                 RL+ + R P E+
Sbjct: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQ--------------SKRLLLERRKPEEK 1369

Query: 771  DDLHESVFRITEQE-KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVV 827
              + E V  +T+++ KL++E  RL   L       EE   +      V  LR+  E    
Sbjct: 1370 VVVQEVV--VTQKDPKLREEHSRLSGSLD------EEVGRRRQLELEVQQLRAGVEEQEG 1421

Query: 828  LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN-----NI 882
            L +  +  S       +L+ + L ++  +     V   + K+  EE V  +K+     + 
Sbjct: 1422 LLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTV---QEKIIMEEVVKLEKDPDLEKST 1478

Query: 883  ENLISTLKQWRSEVDEKRQVFHALE---DELQKAKA----ISDEMFKTYKERDLDFDWHK 935
            E L   L Q +++V E  +    L+   D LQKAK+    I  E+ +  K+R L+     
Sbjct: 1479 EALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLE----- 1533

Query: 936  EKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQ 994
               D+    W+ ++ +   R +  E   + L+   D    L   W ++    QR   +  
Sbjct: 1534 ---DERARVWEMLNRERTAR-QAREEEARRLRERIDRAETLGRTWSREESELQRARDQAD 1589

Query: 995  PE------NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRA 1048
             E        + L  Q  QQ + + E    +SK+   +  +E+  A  +  EL  +    
Sbjct: 1590 QECGRLQQELRALERQKQQQTLQLQE----ESKLLSQKTESERQKAAQRGQELSRLEAAI 1645

Query: 1049 MVDSQQKSPVKRRRMQSSADLIIQEF-MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEK 1107
            + +  Q    +R      A +  +E   + +TR T L T ++      G  +   E  ++
Sbjct: 1646 LREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKR 1705

Query: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
             +       +++ + LQ  +  +    ++   +G  P  ++ +  +  S K+  +  AL+
Sbjct: 1706 GI-------IDRGQYLQ--LQELECDWEEVTTSG--PCGEESVLLDRKSGKQYSIEAALR 1754

Query: 1168 TIQL-----FLAKHGDKMTDEERNELEKQVKTLQE-SYNLLFSESLKQLQESQTSGDVKV 1221
              ++      L K G     E    +  + K     S   + S+S       Q++     
Sbjct: 1755 CRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP 1814

Query: 1222 EEKLDK-----VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
               L        IAG  D TT    S+  AV + ++D  TG +LLE Q    G++    R
Sbjct: 1815 SFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSR 1874

Query: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIKV 1335
            + + +  A   GLI+     +L    KA   I    +   + V +A+ +  +     +  
Sbjct: 1875 ERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPH 1934

Query: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
            L++   TG L+ P    ++ +Q+A    ++S  L   + +  +  KDL DP + E++S  
Sbjct: 1935 LQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYK 1994

Query: 1396 DMVQRSTLQENTGMWLLP 1413
            + + R      +G+ LLP
Sbjct: 1995 EAMGRCRKDPLSGLLLLP 2012



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 175/911 (19%), Positives = 361/911 (39%), Gaps = 130/911 (14%)

Query: 671  IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY--------- 721
            +K +   E    L    SR    LE+ +        +++ L  + +V ++          
Sbjct: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQER 1195

Query: 722  YQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLI------RQIRTPLERDDLHE 775
              E+ +     EQE +     + E+   R  +E   ++L+      R  +  +E  ++ +
Sbjct: 1196 VHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQ 1255

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA-----------SSSVPTLRSEL 824
             V R     ++ +E++RLK  L  + N       Q               + V T     
Sbjct: 1256 EVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSK 1315

Query: 825  NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
             VV    + V    +  + + +      K   A +A+ +L   +L  E     +K  ++ 
Sbjct: 1316 EVVRHEKDPVLEKEAERL-RQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQE 1374

Query: 885  LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT---YKERDLDFDWHKEKADQL 941
            ++ T K  +   +E  ++  +L++E+ + + +  E+ +     +E++    + ++++ +L
Sbjct: 1375 VVVTQKDPKLR-EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKL 1433

Query: 942  -VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKT 1000
             VER      Q+  R+++LE    +++          + I   E  + +   +  ++++ 
Sbjct: 1434 AVERELR---QLTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEA 1480

Query: 1001 LATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1056
            L   L+Q+K  V+E+  +    Q ++D  QK   Q     K+  ++    R + D + + 
Sbjct: 1481 LRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEV-IRVQKDRVLEDERARV 1539

Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF----------AGDSLKRLEEEE 1106
                 R +++     +E   LR R     TL   + +           A     RL++E 
Sbjct: 1540 WEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQEL 1599

Query: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
            ++LE +K++   + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  
Sbjct: 1600 RALERQKQQQTLQLQEESKLLSQ--KTESERQKAAQRGQELSRLEAA-ILREKDQIYEKE 1656

Query: 1167 QTIQLFLAKHGDKMTDEERNELEKQVKTL--------------QESYN--LLFSESLKQL 1210
            +T++   AK   +   +E    E  + T                E+Y   ++      QL
Sbjct: 1657 RTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQL 1716

Query: 1211 QESQ-------TSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLR----GLIDY----D 1255
            QE +       TSG    E  L       +D+ +G+  S+ +A LR       +Y    D
Sbjct: 1717 QELECDWEEVTTSGPCGEESVL-------LDRKSGKQYSI-EAALRCRRISKEEYHLYKD 1768

Query: 1256 TGIRLLETQLMISG------------------LISPELRKCFDLKDAKSHGLIDEQILCQ 1297
              + + E  L+++G                  L SP  +       + S GL D+     
Sbjct: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSF--- 1825

Query: 1298 LKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQ 1357
                     I    +     +  A+A++M+      K+LE   +TG +V   + E+ ++ 
Sbjct: 1826 -----PIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVH 1880

Query: 1358 KAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQ 1417
            KA ++ L+ +    ++L  Q     + DP T +++S+ + VQ+  +   + +  L V+  
Sbjct: 1881 KAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHL 1940

Query: 1418 EGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREG 1477
             GG I  K    I I +A   G+I  E    L         L +  S +R++ +EA+  G
Sbjct: 1941 TGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAM--G 1998

Query: 1478 VIDRDTASSIL 1488
               +D  S +L
Sbjct: 1999 RCRKDPLSGLL 2009



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 194/1033 (18%), Positives = 410/1033 (39%), Gaps = 130/1033 (12%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
            ++TQ+E++  +  Q  Q L    ++   E++V +  +  ++   L LE  E         
Sbjct: 1018 EVTQVERDPGLDSQAAQ-LRIQIQQLRGEDAVISARLEGLKKELLALEKREV-------- 1068

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
                 D+ E V  + E  K++K LE +K          E+   +  A  +V  L++ +  
Sbjct: 1069 -----DVKEKVV-VKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIED 1122

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + + ++ V       + ++K V       Q +  L  L E +  +   +  + +++ +  
Sbjct: 1123 LERAISSVEP--KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180

Query: 887  STLKQWRSEVDEKRQVFHAL------EDELQKAKAISDEMFKTYKERDLDFDWHKEKADQ 940
            S +++ R +V  + +V          E E+ + KA   EM    K   ++ +  K   D 
Sbjct: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEM--AGKRSGVEKEVEKLLPDL 1238

Query: 941  LVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH---PLDDWIQQVETTQRKIQENQPEN 997
             V R Q   V+     +++    +S +  R+       L++ +     +Q ++   Q E 
Sbjct: 1239 EVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGER 1298

Query: 998  SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSP 1057
             +    +   +   VS+  ++  K    +K AE+    V++   +       V   Q   
Sbjct: 1299 DEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKR 1358

Query: 1058 VKRRRMQSSADLIIQEFM------DLRTRYTALVTLMTQYI------KFAGDSLKRLEEE 1105
            +   R +    +++QE +       LR  ++ L   + + +      +     L+   EE
Sbjct: 1359 LLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEE 1418

Query: 1106 EKSL---EEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST--KKE 1160
            ++ L   +E++ + +   +EL++       TL+  E   +PP  ++KI  EE+    K  
Sbjct: 1419 QEGLLSFQEDRSKKLAVERELRQL------TLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472

Query: 1161 QLSEALQTIQLFLAKHGDKMTDEERN--ELEKQVKTLQESYN---LLFSESLK------- 1208
             L ++ + ++  L +   ++T+  R    L+ Q+  LQ++ +    ++ E ++       
Sbjct: 1473 DLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVL 1532

Query: 1209 ---------QLQESQTSGDVKVEE------KLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
                      L   +T+   + EE      ++D+  A T+ +T     S  Q   R   D
Sbjct: 1533 EDERARVWEMLNRERTARQAREEEARRLRERIDR--AETLGRTWSREESELQRA-RDQAD 1589

Query: 1254 YDTG-----IRLLETQLMISGLISPELRKCFDLKDAKSHGLIDE--QILCQLKE-LSKAK 1305
             + G     +R LE Q     L   E  K    K         +  Q L +L+  + + K
Sbjct: 1590 QECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREK 1649

Query: 1306 EIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTG-SLVIPATGEQLTLQKAFQQNL 1364
            + I     T   +   +++  +++    +  E  LST  S++ P TG+ ++  +A+++ +
Sbjct: 1650 DQIYEKERTLRDLHAKVSREELSQETQTR--ETNLSTKISILEPETGKDMSPYEAYKRGI 1707

Query: 1365 VSSALFSKVLERQNMCKDLID--PCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQE---- 1418
            +    + ++ E +   +++    PC  E V L+D            +    +  +E    
Sbjct: 1708 IDRGQYLQLQELECDWEEVTTSGPCGEESV-LLDRKSGKQYSIEAALRCRRISKEEYHLY 1766

Query: 1419 -GGRITL-----------KCGRNISILRAAHEGLI----DRETMFRLLSAQLLSG----- 1457
              G + +           K   ++SI     +  +     + T F   S  L  G     
Sbjct: 1767 KDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFP 1826

Query: 1458 --GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCD 1515
              G+ ++ +  + +++ AV + ++D  T   +L  Q  TGGI+     +R +V +A++  
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886

Query: 1516 LITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYI 1575
            LI ++S   +L AQ+ + G+  P + +      ++Q+  +  E     L  +     L  
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946

Query: 1576 PESSQVIGLDAAKQLGIIDNNTASIL-------KNITLPDKMPDLGDLEACKNARR-WLS 1627
            P+ +  I +  A   G+I    A +L       K++T P     L   EA    R+  LS
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006

Query: 1628 FCKFQPSTVHDYR 1640
                 P+ +  YR
Sbjct: 2007 GLLLLPAALEGYR 2019



 Score = 32.7 bits (73), Expect = 5.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98

Query: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 111/480 (23%), Positives = 205/480 (42%), Gaps = 79/480 (16%)

Query: 1229 IAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHG 1288
            IAG    +T EV+S+ +A  + LI       LLE Q     L+ P  R+   + +A   G
Sbjct: 1899 IAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVG 1958

Query: 1289 LIDEQILCQLKELSKAKE-IISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVI 1347
            L++E++  +L +  +A       A+  TIP+  A+ + +I ++ A+++LE+ ++TG ++ 
Sbjct: 1959 LVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVID 2018

Query: 1348 PATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENT 1407
            P    +L L+ A+++  +   +++ + ++++M K  +DP T EKVS  ++ +R   QE+T
Sbjct: 2019 PQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDT 2078

Query: 1408 GMWLLPV---------------RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSA 1452
            G  L PV               R  E  ++ +  GR     +     L++ E +      
Sbjct: 2079 GWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGR-FRGQKPTLWALLNSEYVTEEKKL 2137

Query: 1453 QLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAV 1512
            QL+     ++    + TV + + E +  ++T++  L +Q    GI      +++T  E +
Sbjct: 2138 QLVRMYRTHTRRALQ-TVAQLILELIEKQETSNKHLWFQ----GI-----RRQITASELL 2187

Query: 1513 QCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAA 1572
               +IT                       +   T  S  QEL+ ++   + L G   IA 
Sbjct: 2188 SSAIITEEML-------------------QDLETGRSTTQELMEDDRVKRYLEGTSCIAG 2228

Query: 1573 LYIPESSQ-----VIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLS 1627
            + +P   Q      + +  A   G++   TA +L              LEA        +
Sbjct: 2229 VLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVL--------------LEA-------QA 2267

Query: 1628 FCKFQPSTVHDYRQEEDVFDGEEPVTTQT--SEETKKLFLSYLMINSYMDANTGQRLLLY 1685
               F    V + R        EEPV      SE  +KL  +   +  Y D  TGQ++ L+
Sbjct: 2268 ATGFVIDPVRNLR-----LSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLF 2322



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 91/382 (23%), Positives = 158/382 (41%), Gaps = 63/382 (16%)

Query: 1229 IAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHG 1288
            IAG   + +G+  SV+ A+ +GL+    G  LLE Q    GL+     +   +  A   G
Sbjct: 43   IAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQG 102

Query: 1289 LIDEQILCQLKELSKAKEIISAASPTT-----IPVLDALAQSMITESMAIKVLEILLSTG 1343
            L+      +LKE   A E  +   P       + +  A+ + ++  ++    LE+ L+TG
Sbjct: 103  LVG----LELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158

Query: 1344 SLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDL--IDPCTSEKVSLIDMVQRS 1401
             LV PA G  +  + A  Q L+    + K+ E +    DL  ++P T E+++   +++R 
Sbjct: 159  GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218

Query: 1402 TLQENTGMWLLPV----------------------------------------------- 1414
                 +G+ LLP+                                               
Sbjct: 219  VRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVR 278

Query: 1415 RPQEG-----GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMT 1469
            R  EG     G + L  G   S  +AA E L+   T   LL AQ  +  L++  +GQR+ 
Sbjct: 279  RYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLW 338

Query: 1470 VEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQ 1529
            V+EAVR G++  +    +L  +    G        ++ + +A++  L+    AL +L+AQ
Sbjct: 339  VDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQ 398

Query: 1530 RGYVGLIWPHSGEIFPTSSSLQ 1551
                GL+ P      P  ++L+
Sbjct: 399  LATGGLVCPARRLRLPLEAALR 420



 Score = 89.4 bits (220), Expect = 5e-17
 Identities = 95/411 (23%), Positives = 178/411 (43%), Gaps = 31/411 (7%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P       +  A 
Sbjct: 685  ERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 744

Query: 1286 SHGLIDEQI-LCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGS 1344
              G  D+ + L  L      K      +   +  L  L + +      + +L +  +   
Sbjct: 745  RRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQSP 804

Query: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
            LV  AT      Q+AFQ NL+ S  + +   ++    +LI+     +     +++R   +
Sbjct: 805  LVDSAT------QQAFQ-NLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQR 857

Query: 1405 ENT---GMWLLPVRPQEGGRITLKCGRN-ISILRAAHEGLIDRETMFRLLSAQLLS---- 1456
            E T      LL    Q    I L   R+ +++ +    G+ID++ + ++L+  +      
Sbjct: 858  EVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALL 917

Query: 1457 ---------------GGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSN 1501
                           GG+    SGQR+++ +A+R+ ++    A ++L  Q  TG I+  +
Sbjct: 918  LMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPH 977

Query: 1502 PAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAY 1561
              + L+VDEAV+  ++       +  A+    G   P SG+      ++++ LI  E A 
Sbjct: 978  SPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAA 1037

Query: 1562 KILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
            ++L  +     +  P S   + +  A Q G +D    + L + +     PD
Sbjct: 1038 RLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSSSETFPTPD 1088



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 85/405 (20%), Positives = 164/405 (40%), Gaps = 36/405 (8%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++  AG  D  +   LS++QA+ +GL+  + G+ LL+ QL   G++ P          A 
Sbjct: 1321 ERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAAC 1380

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITES--------------- 1330
              GL+D Q    L  + K  +     S         L +  + +S               
Sbjct: 1381 RLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVL 1440

Query: 1331 -------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKD- 1382
                   +A++ +++ +STG       G  ++L        V +    K  E   +C+  
Sbjct: 1441 EVDDHTAVALRAMKVPVSTGRF----KGCSVSLWDLLLSEYVGA---DKRRELVALCRSG 1493

Query: 1383 ---LIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAH-- 1437
                +    S   +L++  +R  LQ         V  ++  R  L   + +  L      
Sbjct: 1494 RAAALRQVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTT 1553

Query: 1438 -EGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGG 1496
             + + + +++ R L       G++   + +RM++ EA+R  ++   TA  +L  Q  TG 
Sbjct: 1554 VKEVAEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGF 1613

Query: 1497 IIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELIT 1556
            II     ++LTV+EA +  +    + + +L A+R   G   P++G+      ++Q++LI 
Sbjct: 1614 IIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIV 1673

Query: 1557 NELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
             E   ++L  +     +  P  S  + +D A + G  D     IL
Sbjct: 1674 REHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRIL 1718



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 86/401 (21%), Positives = 170/401 (42%), Gaps = 23/401 (5%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  TG+ +S+FQA+ + LI  + GIRLLE Q+   G+I P       +  A 
Sbjct: 1646 ERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAY 1705

Query: 1286 SHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGS 1344
              G  DE++   L + S   K      +   +  L  L + +      + +L+I+    +
Sbjct: 1706 RCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKKGEN 1765

Query: 1345 LVIPATGEQLTLQKAFQQ--------------NLVSSALFSKVLERQNMCKDLIDPCTSE 1390
             V      +  LQ    +              +L+SS  F++  +R+ + +        E
Sbjct: 1766 YVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEYGAQSGGLE 1825

Query: 1391 KV-SLIDMVQRSTLQENTGMWLLPVRPQEGGR-------ITLKCGRNISILRAAHEGLID 1442
            K+  +I      T  +N G+ +  +R +           I  K    + + R   + L  
Sbjct: 1826 KLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLRVGRTGGQALST 1885

Query: 1443 RETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNP 1502
             E +   L       G+   ++ + M++ EA R+ +I    A+ +L  Q  TG ++    
Sbjct: 1886 LECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCT 1945

Query: 1503 AKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYK 1562
             ++L+VDEAV   L+       +L+A+R   G   P +G+  P   ++Q++LI    A +
Sbjct: 1946 RQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALR 2005

Query: 1563 ILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
            +L  +     +  P+    + L+ A + G +  +  +++ +
Sbjct: 2006 LLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISD 2046



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 84/342 (24%), Positives = 139/342 (40%), Gaps = 54/342 (15%)

Query: 1311 ASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
            AS     V  A+ Q ++   +   +LE   +TG LV  A G+ L + KA QQ LV   L 
Sbjct: 50   ASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELK 109

Query: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNI 1430
             K+L  +       DP   EK++L   + +  +    G   L V+   GG +    G  +
Sbjct: 110  EKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLV 169

Query: 1431 SILRAAHEGLIDRETMFRLLSAQLLSGGL--INSNSGQRMTV------------------ 1470
            +   A H+GL+DRET  +L   +  +G L  +N N+ +R+T                   
Sbjct: 170  APEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALL 229

Query: 1471 -------------------------EEAV---REG---VIDRDTASSILTYQVQTG---G 1496
                                     E+AV   REG    +D    + +  Y   TG   G
Sbjct: 230  PLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAG 289

Query: 1497 IIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELIT 1556
            ++      + +  +A    L+   +AL +LEAQ     L+ P +G+      +++  L++
Sbjct: 290  VVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVS 349

Query: 1557 NELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
             EL  ++L   Q +   + P S   I L  A + G++D   A
Sbjct: 350  PELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLA 391



 Score = 78.6 bits (192), Expect = 9e-14
 Identities = 90/418 (21%), Positives = 180/418 (43%), Gaps = 49/418 (11%)

Query: 1223 EKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLK 1282
            ++ +  IAG  D  +G+ +SVFQA+ +GLI ++   RLLE Q+   G+I P       + 
Sbjct: 1002 KRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMP 1061

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLST 1342
             A   G +D+++   L   S+          T+   L  L +    E+  + +L +  S 
Sbjct: 1062 VAIQRGYVDQEMETALSSSSETFPTPDGQGRTSYAQL--LEECPRDETSGLHLLPLPESA 1119

Query: 1343 GSLVIPATGEQLTLQKAFQQ-----------NLVSSALFSKVLERQNMCKDLIDPCTSEK 1391
                 PA   +  +Q++ Q            +L+SS  F++  +R+ + +D+ +  T+  
Sbjct: 1120 -----PALPTEEQVQRSLQAVPGAKDGTSLWDLLSSCHFTEE-QRRGLLEDVQEGRTTVP 1173

Query: 1392 VSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRN-ISILRAAHEGLIDRETMFRLL 1450
              L+  VQR         W+   +     R+ +   R  +  +     G+I +ET+  L 
Sbjct: 1174 -QLLASVQR---------WVQETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALA 1223

Query: 1451 S-----AQLLS--------------GGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQ 1491
                  AQ+                 G++   SG + ++ +AVR+G++       +L  Q
Sbjct: 1224 QGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQ 1283

Query: 1492 VQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQ 1551
            V +G ++     +RL+V++AV+  L+    +  + +A+R   G   P+S        +++
Sbjct: 1284 VASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAME 1343

Query: 1552 QELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDK 1609
            + L+       +L  +     +  P     +   AA +LG++D  T+ +L  +   +K
Sbjct: 1344 KGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVDKDNK 1401



 Score = 77.0 bits (188), Expect = 3e-13
 Identities = 88/414 (21%), Positives = 162/414 (39%), Gaps = 43/414 (10%)

Query: 1224 KLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKD 1283
            K ++   G  D  TG+ + +FQA+ + LI+    +RLLE Q+   G+I P+      L+ 
Sbjct: 1970 KAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLET 2029

Query: 1284 AKSHGLIDEQILCQL---------------KELSKAKEIISAASP------TTIPVLDAL 1322
            A   G + + I   +               +E    +E+     P         PV  A 
Sbjct: 2030 AYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAA 2089

Query: 1323 AQSMITESMAIKVLE---ILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNM 1379
              S   +    + LE   + ++ G       G++ TL        V+     K L+   M
Sbjct: 2090 RDSEHIDDETRRALEAEQVEITVGRF----RGQKPTLWALLNSEYVTE---EKKLQLVRM 2142

Query: 1380 CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQ-------EGGRITLKCGRNISI 1432
             +            LI  +       N  +W   +R Q           IT +  +++  
Sbjct: 2143 YRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLET 2202

Query: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQ-----RMTVEEAVREGVIDRDTASSI 1487
             R+  + L++ + + R L       G++     Q     +M++ +A+ +GV+   TA  +
Sbjct: 2203 GRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVL 2262

Query: 1488 LTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTS 1547
            L  Q  TG +I      RL+V+E V   ++ S     +L A+R   G   P++G+     
Sbjct: 2263 LEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLF 2322

Query: 1548 SSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
             ++Q++LI  E   ++L  +     +  P  S  + +D A + G  D     +L
Sbjct: 2323 QAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVL 2376



 Score = 76.3 bits (186), Expect = 4e-13
 Identities = 79/323 (24%), Positives = 128/323 (39%), Gaps = 58/323 (17%)

Query: 1219 VKVEEKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPEL 1275
            ++++EKL   ++   G  D   GE L++FQA+ + ++D   G   LE QL   GL+ P  
Sbjct: 106  LELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQ 165

Query: 1276 RKCFDLKDAKSHGLIDEQILCQLKELSKAKE----------------------------- 1306
                  + A   GL+D +   +L EL                                  
Sbjct: 166  GVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCVRAPGSG 225

Query: 1307 ---------------IISAASPTTIPVLDALAQSMITE--------SMAIKVLEILLSTG 1343
                            +SAA    + +LD  A   + E        S   +V   L  TG
Sbjct: 226  LALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTG 285

Query: 1344 SL---VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQR 1400
            S+   V+   G + +  +A  ++L+       +LE Q     L+DP T +++ + + V+ 
Sbjct: 286  SVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRA 345

Query: 1401 STLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLI 1460
              +       LL       G      G  I + +A  +GL+DR    RLL AQL +GGL+
Sbjct: 346  GLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLV 405

Query: 1461 NSNSGQRMTVEEAVREGVIDRDT 1483
                  R+ +E A+R G +D DT
Sbjct: 406  CPARRLRLPLEAALRCGCLDEDT 428



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 89/433 (20%), Positives = 175/433 (40%), Gaps = 55/433 (12%)

Query: 1206 SLKQLQE-SQTSGDVKVEEKLDKV---------IAGTIDQTTGEVLSVFQAVLRGLIDYD 1255
            S K L E SQ +  VK   ++D V         IAG + Q T E +S+ +A+ R ++   
Sbjct: 1540 SRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPG 1599

Query: 1256 TGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT 1315
            T + LLE Q     +I P   +   +++A   G+  ++   +L  LS  + +     P T
Sbjct: 1600 TALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKL--LSAERAVTGYTDPYT 1657

Query: 1316 ---IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372
               I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A++       +   
Sbjct: 1658 GQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRI 1717

Query: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432
            + +  +  K   DP T E ++ + +++R      TG++LL +         +K G N   
Sbjct: 1718 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQI---------IKKGENYVY 1768

Query: 1433 LRAAHEGLIDRETMFRLLSA---------QLLSGGLINSNSGQRMTVEEAVREGVIDR-- 1481
            +  A   ++   T    +            LLS      +  + +  E   + G +++  
Sbjct: 1769 INEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEYGAQSGGLEKLL 1828

Query: 1482 -DTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLI------------TSSSALLVLEA 1528
                ++I   + Q  GI  +     +T  +     +I            T   AL  LE 
Sbjct: 1829 EIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLRVGRTGGQALSTLEC 1888

Query: 1529 QRGYV-------GLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
             + Y+       G+  P + E+     + ++ELI    A  +L  +     L  P + Q 
Sbjct: 1889 VKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQK 1948

Query: 1582 IGLDAAKQLGIID 1594
            + +D A  +G+++
Sbjct: 1949 LSVDEAVDVGLVN 1961



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 95/412 (23%), Positives = 165/412 (40%), Gaps = 50/412 (12%)

Query: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
            ++ + G  D  +G  + +FQA+ +GL+D    +RLL+ QL   GL+ P  R    L+ A 
Sbjct: 360  EQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAAL 419

Query: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
              G +DE      ++LS+A    S  +   +     LA  +      +  L   LS G  
Sbjct: 420  RCGCLDEDTQ---RQLSQAGSF-SDGTHGGLRYEQLLALCVTDPETGLAFLP--LSGG-- 471

Query: 1346 VIPATGEQLT---LQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRST 1402
              P  GE      ++ + +Q L ++     V + +     L +   SE +S     QR+ 
Sbjct: 472  --PRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAIS---SEQRAM 526

Query: 1403 LQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLS------ 1456
            L +      L V  +    ++    +  +  R    GL D  T   LL A+++       
Sbjct: 527  LAQQYQEGTLSVE-KLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYER 585

Query: 1457 ---------------------------GGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
                                        GL+   S +R+++ EA  +G++   TA  +L 
Sbjct: 586  LEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLE 645

Query: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
             Q  TG II     K  +V+EA++  +I       +L A+R   G   P++G+      +
Sbjct: 646  AQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQA 705

Query: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
            +Q+ LI  E   ++L  +     +  P  S  + +D A + G  D     IL
Sbjct: 706  MQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLIL 757



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 55/222 (24%), Positives = 105/222 (47%), Gaps = 10/222 (4%)

Query: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTI----DQT-TGEVLSVFQAVLRGLIDYDTGI 1258
            ++  K LQE      VK   +    IAG +    DQ    E +S++QA+ +G++   T +
Sbjct: 4871 AQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTAL 4930

Query: 1259 RLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT--- 1315
             LLE Q     +I P       +++A + G++  +I  Q K LS  + +     P T   
Sbjct: 4931 VLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEI--QEKLLSAERAVTGYTDPYTGQQ 4988

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A+++      +   + +
Sbjct: 4989 ISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 5048

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQ 1417
              +  K   DP T E ++ + ++QR+TL   TG+  L +  Q
Sbjct: 5049 PSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSLQ 5090



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 77/339 (22%), Positives = 146/339 (43%), Gaps = 43/339 (12%)

Query: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTI----DQT-TGEVLSVFQAVLRGLIDYDTGI 1258
            ++  K LQE      VK   +    IAG +    DQ    E +S++QA+ +G++   T +
Sbjct: 3803 AQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTAL 3862

Query: 1259 RLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT--- 1315
             LLE Q     +I P       +++A + G++  +I  Q K LS  + +     P T   
Sbjct: 3863 VLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEI--QEKLLSAERAVTGYTDPYTGQQ 3920

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A+++      +   + +
Sbjct: 3921 ISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3980

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
              +  K   DP T E ++ + +++R     +TG+++L +            GR      A
Sbjct: 3981 PSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL-----------AGRG----SA 4025

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT-YQVQT 1494
             H+  +  E    L  A++  G    +  GQ ++V E +    +  D    +L+ Y+  T
Sbjct: 4026 VHQ--LSEELRCALRDARVTPGS--GALQGQSVSVWELLFYREVSEDRRQDLLSRYRAST 4081

Query: 1495 GGIIQSNPAKRLTVDE--AVQCDLITSSSALLVLEAQRG 1531
                       LTV+E  A    L+  + A    EA+ G
Sbjct: 4082 -----------LTVEELGATLTSLLAQAQAQARAEAEAG 4109



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 77/339 (22%), Positives = 146/339 (43%), Gaps = 43/339 (12%)

Query: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTI----DQT-TGEVLSVFQAVLRGLIDYDTGI 1258
            ++  K LQE      VK   +    IAG +    DQ    E +S++QA+ +G++   T +
Sbjct: 2735 AQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTAL 2794

Query: 1259 RLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT--- 1315
             LLE Q     +I P       +++A + G++  +I  Q K LS  + +     P T   
Sbjct: 2795 VLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEI--QEKLLSAERAVTGYTDPYTGQQ 2852

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A+++      +   + +
Sbjct: 2853 ISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2912

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
              +  K   DP T E ++ + +++R     +TG+++L +            GR      A
Sbjct: 2913 PSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL-----------AGRG----SA 2957

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT-YQVQT 1494
             H+  +  E    L  A++  G    +  GQ ++V E +    +  D    +L+ Y+  T
Sbjct: 2958 VHQ--LSEELRCALRDARVTPGS--GALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGT 3013

Query: 1495 GGIIQSNPAKRLTVDE--AVQCDLITSSSALLVLEAQRG 1531
                       LTV+E  A    L+  + A    EA+ G
Sbjct: 3014 -----------LTVEELGATLTSLLAQAQAQARAEAEAG 3041



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 77/339 (22%), Positives = 146/339 (43%), Gaps = 43/339 (12%)

Query: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTI----DQT-TGEVLSVFQAVLRGLIDYDTGI 1258
            ++  K LQE      VK   +    IAG +    DQ    E +S++QA+ +G++   T +
Sbjct: 3269 AQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTAL 3328

Query: 1259 RLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT--- 1315
             LLE Q     +I P       +++A + G++  +I  Q K LS  + +     P T   
Sbjct: 3329 VLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEI--QEKLLSAERAVTGYTDPYTGQQ 3386

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A+++      +   + +
Sbjct: 3387 ISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3446

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
              +  K   DP T E ++ + +++R     +TG+++L +            GR      A
Sbjct: 3447 PSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL-----------AGRG----SA 3491

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT-YQVQT 1494
             H+  +  E    L  A++  G    +  GQ ++V E +    +  D    +L+ Y+  T
Sbjct: 3492 VHQ--LSEELRCALRDARVTPGS--GALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGT 3547

Query: 1495 GGIIQSNPAKRLTVDE--AVQCDLITSSSALLVLEAQRG 1531
                       LTV+E  A    L+  + A    EA+ G
Sbjct: 3548 -----------LTVEELGATLTSLLAQAQAQARAEAEAG 3575



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 77/339 (22%), Positives = 146/339 (43%), Gaps = 43/339 (12%)

Query: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTI----DQT-TGEVLSVFQAVLRGLIDYDTGI 1258
            ++  K LQE      VK   +    IAG +    DQ    E +S++QA+ +G++   T +
Sbjct: 4337 AQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTAL 4396

Query: 1259 RLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT--- 1315
             LLE Q     +I P       +++A + G++  +I  Q K LS  + +     P T   
Sbjct: 4397 VLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEI--QEKLLSAERAVTGYTDPYTGQQ 4454

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            I +  A+ + +I     I++LE  ++TG ++ P    ++ +  A+++      +   + +
Sbjct: 4455 ISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 4514

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
              +  K   DP T E ++ + +++R     +TG+++L +            GR      A
Sbjct: 4515 PSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL-----------AGRG----SA 4559

Query: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT-YQVQT 1494
             H+  +  E    L  A++  G    +  GQ ++V E +    +  D    +L+ Y+  T
Sbjct: 4560 VHQ--LSEELRCALRDARVTPGS--GALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGT 4615

Query: 1495 GGIIQSNPAKRLTVDE--AVQCDLITSSSALLVLEAQRG 1531
                       LTV+E  A    L+  + A    EA+ G
Sbjct: 4616 -----------LTVEELGATLTSLLAQAQAQARAEAEAG 4643



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 47/187 (25%), Positives = 88/187 (47%), Gaps = 1/187 (0%)

Query: 1229 IAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHG 1288
            +AG + Q +G   S+ QAV  GL+    G RLLE Q+    L+ P   +   ++DA   G
Sbjct: 1248 VAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVG 1307

Query: 1289 LIDEQILCQLKELSKAKE-IISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVI 1347
            L+  ++  QL +  +A        S  ++ +  A+ + ++ ++  + +L++ L+TG +V 
Sbjct: 1308 LVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVD 1367

Query: 1348 PATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENT 1407
            P  G  L    A +  L+ +     +       K   DP   ++V+   + +R      T
Sbjct: 1368 PVHGVHLPQAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSET 1427

Query: 1408 GMWLLPV 1414
            G+ LLP+
Sbjct: 1428 GLLLLPL 1434



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 105/522 (20%), Positives = 203/522 (38%), Gaps = 79/522 (15%)

Query: 1143 PPFSKQKISSEEISTKKEQLSEAL---QTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1199
            PPF K   + + +ST    +S      + + L+     + ++ E+R  L +Q +    S 
Sbjct: 480  PPFIKYS-TRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSV 538

Query: 1200 NLLFSESLKQLQESQTSGDVKVEEKLDKVIAGT------IDQTTGEVLSVFQAVLRGLID 1253
              L +E    L+++  +  V      D V  G       IDQ   E L   QA  + +  
Sbjct: 539  EKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGS 598

Query: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKE-IISAAS 1312
              +  R L+    I+GL+ P  ++   + +A+  GL+       L E   A   II   +
Sbjct: 599  LASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKA 658

Query: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372
                 V +AL  ++I   +  K+L    +      P TG+Q++L +A Q+ L+      +
Sbjct: 659  NKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIR 718

Query: 1373 VLERQ--------------------------------------NMCKDLIDPCTSEKVSL 1394
            +LE Q                                      +  K   DP T E ++ 
Sbjct: 719  LLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTY 778

Query: 1395 IDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL 1454
            + +++R      TG++LLP+   +   +        S  + A + L+      R    ++
Sbjct: 779  LQLLERCVRDPETGLYLLPLSSTQSPLVD-------SATQQAFQNLLLSVKYGRFQGQRV 831

Query: 1455 LSGGLINS---NSGQRMTVEEAVREGVIDRDTASSILTYQVQ-TGGIIQSNPAKRLTVDE 1510
             +  LINS   + G+R  +    R+  +     + +L  + Q    I+      R+TV +
Sbjct: 832  SAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQ 891

Query: 1511 AVQCDLI------------TSSSALLVLEAQRGYV-------GLIWPHSGEIFPTSSSLQ 1551
             ++  +I             S  ALL+++  R Y+       G+    SG+      +++
Sbjct: 892  LLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMR 951

Query: 1552 QELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGII 1593
            Q+L+   +A  +L  +     +  P S + + +D A + G++
Sbjct: 952  QKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVV 993



 Score = 65.5 bits (158), Expect = 8e-10
 Identities = 84/423 (19%), Positives = 179/423 (42%), Gaps = 64/423 (15%)

Query: 1141 GKPPFSKQKISSEEISTKKE---------QLSEALQTIQLFLAKHGDKMTDEERN----E 1187
            G+ P     ++SE ++ +K+             ALQT+   + +  +K     ++     
Sbjct: 2117 GQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQG 2176

Query: 1188 LEKQVKTLQESYNLLFSESLKQLQES--QTSGDVKVEEKLDKVIAGTI----------DQ 1235
            + +Q+   +   + + +E + Q  E+   T+ ++  ++++ + + GT           DQ
Sbjct: 2177 IRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQ 2236

Query: 1236 T-TGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQI 1294
                E +S++QA+ +G++   T + LLE Q     +I P       +++    G++  +I
Sbjct: 2237 PGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEI 2296

Query: 1295 LCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATG 1351
              Q K LS  + +     P T   I +  A+ + +I     I++LE  ++TG ++ P   
Sbjct: 2297 --QEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHS 2354

Query: 1352 EQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWL 1411
             ++ +  A+++      +   + +  +  K   DP T E ++ + +++R     +TG+++
Sbjct: 2355 HRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYM 2414

Query: 1412 LPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVE 1471
            L +            GR      A H+  +  E    L  A++  G    +  GQ ++V 
Sbjct: 2415 LQL-----------AGRG----SAVHQ--LSEELRCALRDARVTPGS--GALQGQSVSVW 2455

Query: 1472 EAVREGVIDRDTASSILT-YQVQTGGIIQSNPAKRLTVDE--AVQCDLITSSSALLVLEA 1528
            E +    +  D    +L+ Y+  T           LTV+E  A    L+  + A    EA
Sbjct: 2456 ELLFYREVSEDRRQDLLSRYRAGT-----------LTVEELGATLTSLLAQAQAQARAEA 2504

Query: 1529 QRG 1531
            + G
Sbjct: 2505 EAG 2507



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 51/253 (20%), Positives = 114/253 (45%), Gaps = 13/253 (5%)

Query: 1223 EKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLK 1282
            EKL ++I  TI++T  +   +  A +RG +   T   L  ++++       + +    L+
Sbjct: 1825 EKLLEIITTTIEETETQNQGIKVAAIRGEV---TAADLFNSRVI-------DQKTLHTLR 1874

Query: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVL---DALAQSMITESMAIKVLEIL 1339
              ++ G     + C    L  +  I     P+T  V+   +A  + +I  + A  +LE  
Sbjct: 1875 VGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQ 1934

Query: 1340 LSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQ 1399
             +TG L+ P T ++L++ +A    LV+  L  ++L+ +       DP T + + L   +Q
Sbjct: 1935 AATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQ 1994

Query: 1400 RSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGL 1459
            +  +++   + LL V+   GG I  +    + +  A   G + ++    +   + +    
Sbjct: 1995 KQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRF 2054

Query: 1460 INSNSGQRMTVEE 1472
            ++ N+ ++++  E
Sbjct: 2055 VDPNTQEKVSYRE 2067



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 70/307 (22%), Positives = 129/307 (42%), Gaps = 24/307 (7%)

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            + V D L  S ++E+   ++L    + G+L +P     LT      +  +S   F + L 
Sbjct: 4791 VSVWDVLFSSYLSEARRDELLA-QHAAGALGLPDLVAVLTRVIEETEERLSKVSF-RGLR 4848

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRS-TLQENTGM---------------WLLPVRPQEG 1419
            RQ    +L         +L D+ Q + TLQE T M                L+P + Q G
Sbjct: 4849 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 4908

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
             +        +SI +A  +G++   T   LL AQ  +G +I+     R++VEEAV  GV+
Sbjct: 4909 RQ------EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVV 4962

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPH 1539
              +    +L+ +    G       +++++ +A+Q DLI     + +LEAQ    G+I P 
Sbjct: 4963 GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPV 5022

Query: 1540 SGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTAS 1599
                 P   + ++     E+   + +        + P + + +      Q   +D  T  
Sbjct: 5023 HSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGL 5082

Query: 1600 ILKNITL 1606
            +  +++L
Sbjct: 5083 LFLSLSL 5089



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 66/136 (48%)

Query: 1466 QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
            ++M++ +A+ +GV+   TA  +L  Q  TG +I      RL+V+EAV   ++       +
Sbjct: 2775 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 2834

Query: 1526 LEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLD 1585
            L A+R   G   P++G+      ++Q++LI  E   ++L  +     +  P  S  + +D
Sbjct: 2835 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 2894

Query: 1586 AAKQLGIIDNNTASIL 1601
             A + G  D     +L
Sbjct: 2895 VAYRRGYFDEEMNRVL 2910



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 66/136 (48%)

Query: 1466 QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
            ++M++ +A+ +GV+   TA  +L  Q  TG +I      RL+V+EAV   ++       +
Sbjct: 3309 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3368

Query: 1526 LEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLD 1585
            L A+R   G   P++G+      ++Q++LI  E   ++L  +     +  P  S  + +D
Sbjct: 3369 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3428

Query: 1586 AAKQLGIIDNNTASIL 1601
             A + G  D     +L
Sbjct: 3429 VAYRRGYFDEEMNRVL 3444



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 66/136 (48%)

Query: 1466 QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
            ++M++ +A+ +GV+   TA  +L  Q  TG +I      RL+V+EAV   ++       +
Sbjct: 3843 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3902

Query: 1526 LEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLD 1585
            L A+R   G   P++G+      ++Q++LI  E   ++L  +     +  P  S  + +D
Sbjct: 3903 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3962

Query: 1586 AAKQLGIIDNNTASIL 1601
             A + G  D     +L
Sbjct: 3963 VAYRRGYFDEEMNRVL 3978



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 66/136 (48%)

Query: 1466 QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
            ++M++ +A+ +GV+   TA  +L  Q  TG +I      RL+V+EAV   ++       +
Sbjct: 4377 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4436

Query: 1526 LEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLD 1585
            L A+R   G   P++G+      ++Q++LI  E   ++L  +     +  P  S  + +D
Sbjct: 4437 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 4496

Query: 1586 AAKQLGIIDNNTASIL 1601
             A + G  D     +L
Sbjct: 4497 VAYRRGYFDEEMNRVL 4512



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 65/260 (25%), Positives = 113/260 (43%), Gaps = 24/260 (9%)

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            + V D L  S ++E+   ++L    + G+L +P     LT      +  +S   F + L 
Sbjct: 2655 VSVWDVLFSSYLSEARRDELLA-QHAAGALGLPDLVAVLTRVIEETEERLSKVSF-RGLR 2712

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRS-TLQENTGM---------------WLLPVRPQEG 1419
            RQ    +L         +L D+ Q + TLQE T M                L+P + Q G
Sbjct: 2713 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 2772

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
             +        +SI +A  +G++   T   LL AQ  +G +I+     R++VEEAV  GV+
Sbjct: 2773 RQ------EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVV 2826

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPH 1539
              +    +L+ +    G       +++++ +A+Q DLI     + +LEAQ    G+I P 
Sbjct: 2827 GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPV 2886

Query: 1540 SGEIFPTSSSLQQELITNEL 1559
                 P   + ++     E+
Sbjct: 2887 HSHRVPVDVAYRRGYFDEEM 2906



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 65/260 (25%), Positives = 113/260 (43%), Gaps = 24/260 (9%)

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            + V D L  S ++E+   ++L    + G+L +P     LT      +  +S   F + L 
Sbjct: 3189 VSVWDVLFSSYLSEARRDELLA-QHAAGALGLPDLVAVLTRVIEETEERLSKVSF-RGLR 3246

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRS-TLQENTGM---------------WLLPVRPQEG 1419
            RQ    +L         +L D+ Q + TLQE T M                L+P + Q G
Sbjct: 3247 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 3306

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
             +        +SI +A  +G++   T   LL AQ  +G +I+     R++VEEAV  GV+
Sbjct: 3307 RQ------EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVV 3360

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPH 1539
              +    +L+ +    G       +++++ +A+Q DLI     + +LEAQ    G+I P 
Sbjct: 3361 GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPV 3420

Query: 1540 SGEIFPTSSSLQQELITNEL 1559
                 P   + ++     E+
Sbjct: 3421 HSHRVPVDVAYRRGYFDEEM 3440



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 65/260 (25%), Positives = 113/260 (43%), Gaps = 24/260 (9%)

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            + V D L  S ++E+   ++L    + G+L +P     LT      +  +S   F + L 
Sbjct: 3723 VSVWDVLFSSYLSEARRDELLA-QHAAGALGLPDLVAVLTRVIEETEERLSKVSF-RGLR 3780

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRS-TLQENTGM---------------WLLPVRPQEG 1419
            RQ    +L         +L D+ Q + TLQE T M                L+P + Q G
Sbjct: 3781 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 3840

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
             +        +SI +A  +G++   T   LL AQ  +G +I+     R++VEEAV  GV+
Sbjct: 3841 RQ------EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVV 3894

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPH 1539
              +    +L+ +    G       +++++ +A+Q DLI     + +LEAQ    G+I P 
Sbjct: 3895 GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPV 3954

Query: 1540 SGEIFPTSSSLQQELITNEL 1559
                 P   + ++     E+
Sbjct: 3955 HSHRVPVDVAYRRGYFDEEM 3974



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 65/260 (25%), Positives = 113/260 (43%), Gaps = 24/260 (9%)

Query: 1316 IPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLE 1375
            + V D L  S ++E+   ++L    + G+L +P     LT      +  +S   F + L 
Sbjct: 4257 VSVWDVLFSSYLSEARRDELLA-QHAAGALGLPDLVAVLTRVIEETEERLSKVSF-RGLR 4314

Query: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRS-TLQENTGM---------------WLLPVRPQEG 1419
            RQ    +L         +L D+ Q + TLQE T M                L+P + Q G
Sbjct: 4315 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 4374

Query: 1420 GRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
             +        +SI +A  +G++   T   LL AQ  +G +I+     R++VEEAV  GV+
Sbjct: 4375 RQ------EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVV 4428

Query: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPH 1539
              +    +L+ +    G       +++++ +A+Q DLI     + +LEAQ    G+I P 
Sbjct: 4429 GGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPV 4488

Query: 1540 SGEIFPTSSSLQQELITNEL 1559
                 P   + ++     E+
Sbjct: 4489 HSHRVPVDVAYRRGYFDEEM 4508



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 47/222 (21%), Positives = 96/222 (43%), Gaps = 8/222 (3%)

Query: 1313 PTTIPVLDALAQSMITESMAIKV------LEILLSTGSLVIPATGEQLTLQKAFQQNLVS 1366
            P  +P  ++  Q+ +  +MA  +           S   + + A+G+  ++  A +Q L+ 
Sbjct: 8    PLPVPGTNSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLP 67

Query: 1367 SALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC 1426
            + L   +LE Q     L+D    + + +   +Q+  +       LL       G      
Sbjct: 68   AGLGQALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYG 127

Query: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
            G  +++ +A  + ++DR      L  QL +GGL++   G  +  E A  +G++DR+T   
Sbjct: 128  GEKLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHK 187

Query: 1487 ILTYQVQTGGI--IQSNPAKRLTVDEAVQCDLITSSSALLVL 1526
            +   +  TG +  +  N  +RLT  + ++  +    S L +L
Sbjct: 188  LSELEPGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALL 229



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 48/220 (21%), Positives = 97/220 (44%), Gaps = 10/220 (4%)

Query: 1315 TIPVLDALAQ-----SMITESMAIKVLEILLSTG---SLVIPATGEQLTLQKAFQQNLVS 1366
            T   L+ALAQ     + + E  A+K    L  TG    +++  +G + ++ +A +  L+ 
Sbjct: 1215 TQETLEALAQGTQSPAQVAEQPAVKAC--LWGTGCVAGVLLQPSGAKASIAQAVRDGLLP 1272

Query: 1367 SALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC 1426
            + L  ++LE Q     L+DP  ++++S+ D V+   +       L        G      
Sbjct: 1273 TGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAAGYPDPYS 1332

Query: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
              ++S+ +A  +GL+ +     LL  QL +GG+++   G  +    A R G++D  T+  
Sbjct: 1333 RASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLLDTQTSQV 1392

Query: 1487 ILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVL 1526
            +             +   ++T  +  +  +  S + LL+L
Sbjct: 1393 LTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLL 1432



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 38/159 (23%), Positives = 67/159 (42%), Gaps = 5/159 (3%)

Query: 1458 GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLI 1517
            G+    SGQ  +V  A+ +G++      ++L  Q  TGG++     + L V +A+Q  L+
Sbjct: 45   GVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQGLV 104

Query: 1518 TSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPE 1577
                   +L A+R   G   P+ GE      ++ +E++   L    L  +     L  P 
Sbjct: 105  GLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPA 164

Query: 1578 SSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDL 1616
               ++  + A   G++D  T   L  +      P  GDL
Sbjct: 165  QGVLVAPEPACHQGLLDRETWHKLSELE-----PGTGDL 198


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 212/1018 (20%), Positives = 407/1018 (39%), Gaps = 119/1018 (11%)

Query: 267  LLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENHKNVHRAIE-E 324
            L+++N+T E    + + + L+   E++ Q+ RT   S+ P     H  N     R ++ E
Sbjct: 408  LMEENMTLEMAQKQSMDESLHLGWELE-QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 325  FESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATN 384
             E+      + E++ T          +  +E   +K+L   +  +R    L   V    N
Sbjct: 467  MENQSLTKTVEELRTT----------VDSVEGNASKILKMEKENQR----LSKKVEILEN 512

Query: 385  ELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ----LL 440
            E++   EK+  +   + S+             +LM+E  Q E+ I++++E +E+    L 
Sbjct: 513  EIV--QEKQSLQNCQNLSK-------------DLMKEKAQLEKTIETLRENSERQIKILE 557

Query: 441  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD 500
             EN     T+ + R   Q      +     V+   KEN    E   +       +   K 
Sbjct: 558  QENEHLNQTVSSLRQRSQ------ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611

Query: 501  AIQRKYSCDRSSSIHKLEDLVQE--SMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 558
             I+++    +     + E+L  E   +E++ ELLQ K  I NL    + I  L+  NS+ 
Sbjct: 612  QIKKELEHYKEKG-ERAEELENELHHLEKENELLQKK--ITNLKITCEKIEALEQENSEL 668

Query: 559  PLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPP 618
              +     K +  ++ +   +       L   + +   + +    N   +      +   
Sbjct: 669  ERENRKLKKTLDSFKNLTFQLES-----LEKENSQLDEENLELRRNVESLKCASMKMAQL 723

Query: 619  NKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGE 678
              E  +L +  EQ  + +  L        +  VS+  L  E  R++ +   S K +    
Sbjct: 724  QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI---- 779

Query: 679  HQQVLSNLQS--RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 736
             QQ+ S LQ        L+ + E    S   + QLEKE    +Q   +L K  ++ E+E 
Sbjct: 780  -QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838

Query: 737  SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD--DLHESVFRITEQEKLKKEL-ERL 793
                   +E+++  L   N +   + +    L ++     ES  R+ E EK  KEL +R 
Sbjct: 839  KRLRQQ-AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897

Query: 794  KDDLGTITNKCEEFFSQ----AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN 849
              D+ T+    E+  S+       ++ +  L  EL  +  N  ++     +  D+ K + 
Sbjct: 898  TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957

Query: 850  LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHAL--- 906
              L++T     L K  E K   EE + A +  +E   +  +Q R E+   ++ + AL   
Sbjct: 958  SKLEST-----LKKSLEIK---EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009

Query: 907  EDE---LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-RWQNVHVQ-----IDNRLR 957
            +DE   +Q +  IS E  K  +E         +  D+L+E    N  +Q     +  +L+
Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069

Query: 958  DLEGIGKSLK-----YYRDTYHPLDDWIQQVETTQRKIQ-ENQPENSKTLATQLNQQKML 1011
             LE    +L+       R T   L +    ++T   K+Q EN   NS++ +      ++L
Sbjct: 1070 QLETQNNNLQAQILALQRQTV-SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1128

Query: 1012 VSEIEMK---QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD 1068
            + +  ++   +S + E +     Y + +KD+E   + +       +    K   ++S+  
Sbjct: 1129 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1188

Query: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVS 1128
             +  E  DL  RY  L+    Q      D  K L+ E++ +  E K H   A E +K   
Sbjct: 1189 NLEVEHRDLEDRYNQLLKQKGQ----LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1244

Query: 1129 -------NISKTLKDAE------KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAK 1175
                     S+ LK+ E      K  K   +  K+    +  +  +L E  Q + +   K
Sbjct: 1245 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK 1304

Query: 1176 HGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD---VKVEEKLDKV 1228
              +  ++  + +  LE++ + L +    L  ++   L+++  S D   V+  + +DK+
Sbjct: 1305 LNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 165/868 (19%), Positives = 363/868 (41%), Gaps = 131/868 (15%)

Query: 408  IARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467
            +  K +   +  +EL+Q E  +K +Q+    LL +   AR+    YR  +       +++
Sbjct: 267  LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM----YRDELDALREKAVRV 322

Query: 468  CQCVEQ--HIKENTAYFEFFN----DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLV 521
             +   +    KE     EF+     + KE    L   K  ++ +    R+ S  KL +L 
Sbjct: 323  DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELE 381

Query: 522  QESMEEKEELLQY-------KSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
            +E+++ K +L          +  I  LM +  T+   + ++ D  L     ++ I    +
Sbjct: 382  KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 575  I-------------EITIYKDDECVLANNS-----HRAKWKVISPTGNEAMVPSVCFTVP 616
            +             E+T  +  +  + N S        +  V S  GN + +  +     
Sbjct: 442  LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501

Query: 617  PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTM-L 675
              +K+   L N I Q+ Q++    + S   MK       L   I+ +R ++   IK +  
Sbjct: 502  RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ---LEKTIETLRENSERQIKILEQ 558

Query: 676  PGEH-QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQ 734
              EH  Q +S+L+ R          SQ+ + + +  +EKE  +  +  +E      + E 
Sbjct: 559  ENEHLNQTVSSLRQR----------SQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608

Query: 735  EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLK 794
            E+          R I+  LE+ +++         ER +  E+     E   L+KE E L+
Sbjct: 609  EK----------RQIKKELEHYKEK--------GERAEELEN-----ELHHLEKENELLQ 645

Query: 795  DDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM-NQVYSMSSTYIDKLKTVNLVLK 853
              +  +   CE+  +    +S +     +L   L +  N  + + S          L  +
Sbjct: 646  KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----------LEKE 695

Query: 854  NTQAAEALVKLYETKLCEEEAVIADKNNIENL-ISTLKQWRSEVDEKRQVFHALEDELQK 912
            N+Q  E  ++L              + N+E+L  +++K  + +++ K     + +++L+K
Sbjct: 696  NSQLDEENLEL--------------RRNVESLKCASMKMAQLQLENKE--LESEKEQLKK 739

Query: 913  AKAISDEMFKTYKERDLDF---DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY 969
               +    FK  +  ++ +   D   ++  + +E       Q+++ L+DLE   ++L+  
Sbjct: 740  GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799

Query: 970  RDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1029
             +        ++Q+E   + +++   +  K       + K L  + E+K + +       
Sbjct: 800  LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL------- 852

Query: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ-SSADLIIQEFMDLRTRYTALVTLM 1088
            E+ +  + + E +  T    +   ++S V+ + ++  + +L+ +  +D++T  T    L+
Sbjct: 853  EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912

Query: 1089 TQYIKF--AGDSLKRL--EEEEKSLEEEKKEHVEKAKE--LQKWVSNISKTLKDAEKAGK 1142
            ++ +K     + L++L  E E+  L +E+  H E++ +   +   S +  TLK + +  +
Sbjct: 913  SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKE 972

Query: 1143 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1202
               +  +   EE +   +QL + L+T++    K+ + +  ++R + E+ V    +S   +
Sbjct: 973  EKIAALEARLEESTNYNQQLRQELKTVK----KNYEAL--KQRQDEERMV----QSSPPI 1022

Query: 1203 FSESLKQLQESQ--TSGDVKVEEKLDKV 1228
              E  K  +ESQ  T   +KV+++L +V
Sbjct: 1023 SGEDNKWERESQETTRELLKVKDRLIEV 1050



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 181/955 (18%), Positives = 377/955 (39%), Gaps = 162/955 (16%)

Query: 248  NSLQTLKLMQIRKPLLK---SSLLDQNLTEEEINMKFVQD----LLNWVDEMQVQLDRTE 300
            NS + +K+++     L    SSL  ++    E  +K ++     L   + E   +L + E
Sbjct: 548  NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSL----KEAKISEIQMTAPLKLTYAEKLHRLES 356
            +  +   ++  LE++K      EE E+ L    KE ++ + ++T  LK+T  EK+  LE 
Sbjct: 608  F--EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN-LKIT-CEKIEALEQ 663

Query: 357  QYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 416
            + ++L   +R  ++ LD+  N   +       L   E+E    D  E N           
Sbjct: 664  ENSELERENRKLKKTLDSFKNLTFQ-------LESLEKENSQLD--EENL---------- 704

Query: 417  ELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIK 476
                EL +  E++K       QL LEN       E  +  ++     +L+      + ++
Sbjct: 705  ----ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-----LLKASFKKTERLE 755

Query: 477  ENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKS 536
             +    +  N   + T  L N    IQ+  S        +L+DL  E+   ++ L + K 
Sbjct: 756  VSYQGLDIENQRLQKT--LENSNKKIQQLES--------ELQDLEMENQTLQKNLEELKI 805

Query: 537  TIANLMGKAKTIIQLKPRNSDCPLKTS----------IPIKAICDYRQIEITIYKDDECV 586
            +       +K + QL+  N     +TS             K +    +I+ T  +++   
Sbjct: 806  S-------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHIN 646
            + N     K    + +    +    C  +    KE  +L  R     + ++TL  E  ++
Sbjct: 859  IGNLEKENK----TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL-REDLVS 913

Query: 647  MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 706
             K  +    + N+++++               H+  L  +    E  L D Q +      
Sbjct: 914  EK--LKTQQMNNDLEKL--------------THE--LEKIGLNKERLLHDEQSTDDRYKL 955

Query: 707  DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI-SEVRNIR-----LRLENCEDRL 760
              ++LE  +    +  +E + + E   +E + YN  +  E++ ++     L+    E+R+
Sbjct: 956  LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1015

Query: 761  IRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            + Q   P+  +D         E ++  +EL ++KD L  +        + A   +    L
Sbjct: 1016 V-QSSPPISGEDNKWE----RESQETTRELLKVKDRLIEVER------NNATLQAEKQAL 1064

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT--QAAEALVKLYETKLCEEEAVIAD 878
            +++L  +    N + +       + +TV+L  +NT  Q   A +++  + L  +   + +
Sbjct: 1065 KTQLKQLETQNNNLQAQILAL--QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1122

Query: 879  KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKA 938
            +N        L Q  S  +E   V    ED     K++ D + K +++ +L  +    + 
Sbjct: 1123 QN-----AQLLIQQSSLENENESVIKERED----LKSLYDSLIKDHEKLELLHERQASEY 1173

Query: 939  DQLVER---WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP 995
            + L+ +    ++ H  ++   RDLE          D Y+ L     Q+E  ++ +   + 
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLE----------DRYNQLLKQKGQLEDLEKML---KV 1220

Query: 996  ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
            E  K L    N + +     ++      E  +    YS  +K+ E+    ++ +      
Sbjct: 1221 EQEKMLLENKNHETVAAEYKKL----CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1276

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKE 1115
            S +++ R+++       EF  L+ +Y  L    T+      +  + L + + +LEEE + 
Sbjct: 1277 SKLEQTRLEA-------EFSKLKEQYQQLDITSTK----LNNQCELLSQLKGNLEEENRH 1325

Query: 1116 HVEKAKELQKWVSNISKTLKDAEKAGKPPF---SKQKISS-EEISTKKEQLSEAL 1166
             +++ + L       ++TL +     K  F    +Q I    E+  +KE+L E +
Sbjct: 1326 LLDQIQTLMLQ----NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 110/551 (19%), Positives = 227/551 (41%), Gaps = 80/551 (14%)

Query: 730  EREEQEESVYNLYISEV-----RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE 784
            E    +E+V++L   EV      +I   L+N    L R I    ERD+  E++  ++E+ 
Sbjct: 162  EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLID---ERDEHSETIIELSEER 218

Query: 785  K----LKKELERLKDDLGTITNKCEEFFSQ-----AAASSSVPTLRSELNVVLQNM---N 832
                 L       +   G+   K  E         A A + +  LR EL    + +    
Sbjct: 219  DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCK 278

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ- 891
            Q        + +L+  N+ L +  A  A +   E     E+AV  DK  +E+ +S  K+ 
Sbjct: 279  QELEQMEIELKRLQQENMNLLS-DARSARMYRDELDALREKAVRVDK--LESEVSRYKER 335

Query: 892  ------WRSEVDEKRQVFHAL-------EDELQKAKAISDEMFKTYKER----------D 928
                  +++ V+E ++    L       ED+L+  +A SD++ +  KE           +
Sbjct: 336  LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395

Query: 929  LDFDWHKEKADQLVERWQNVHV----QIDNRLR---DLEGIGKSLKYYRDTYHPLDDWIQ 981
            ++ D  ++K ++L+E    + +     +D  L    +LE I ++ +        L   + 
Sbjct: 396  MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455

Query: 982  QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYEL 1041
              E T  ++ + + EN ++L   + + +  V  +E   SK+ + +K  ++ S  V+  E 
Sbjct: 456  --ELTSSRLLKLEMEN-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 1042 QTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-- 1099
            + +  +  + + Q       + ++  +  I+   +   R   ++    +++     SL  
Sbjct: 513  EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572

Query: 1100 ----------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK 1149
                      K +E+E K L E  KE   K  +++     I K L+  ++ G+     ++
Sbjct: 573  RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEE 629

Query: 1150 ISSE--EISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ----VKTLQESYNLLF 1203
            + +E   +  + E L + +  +++   K   +  ++E +ELE++     KTL    NL F
Sbjct: 630  LENELHHLEKENELLQKKITNLKITCEK--IEALEQENSELERENRKLKKTLDSFKNLTF 687

Query: 1204 SESLKQLQESQ 1214
                 + + SQ
Sbjct: 688  QLESLEKENSQ 698



 Score = 32.7 bits (73), Expect = 5.7
 Identities = 54/268 (20%), Positives = 104/268 (38%), Gaps = 24/268 (8%)

Query: 989  KIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT--- 1045
            K  E++   S  LA    + + L  E+E K  ++ +C++  EQ    +K  + + M    
Sbjct: 241  KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 1046 -------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS 1098
                   YR  +D+ ++  V+  +++S      +   D+   Y A V  + +  +   ++
Sbjct: 301  DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF-YKARVEELKEDNQVLLET 359

Query: 1099 LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
               LE++     E  +   +K  EL+K    +   L D E        K +++  E ++ 
Sbjct: 360  KTMLEDQ----LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
            +  Q     +++ L         T E     E   K+L    N L S  L +L+    S 
Sbjct: 416  EMAQKQSMDESLHLGWELEQISRTSELS---EAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSVFQ 1245
               VEE     +  T+D   G    + +
Sbjct: 473  TKTVEE-----LRTTVDSVEGNASKILK 495


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 213/1019 (20%), Positives = 407/1019 (39%), Gaps = 120/1019 (11%)

Query: 267  LLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENHKNVHRAIE-E 324
            L+++N+T E    + + + L+   E++ Q+ RT   S+ P     H  N     R ++ E
Sbjct: 408  LMEENMTLEMAQKQSMDESLHLGWELE-QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 325  FESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATN 384
             E+      + E++ T          +  +E   +K+L   +  +R    L   V    N
Sbjct: 467  MENQSLTKTVEELRTT----------VDSVEGNASKILKMEKENQR----LSKKVEILEN 512

Query: 385  ELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ----LL 440
            E++   EK+  +   + S+             +LM+E  Q E+ I++++E +E+    L 
Sbjct: 513  EIV--QEKQSLQNCQNLSK-------------DLMKEKAQLEKTIETLRENSERQIKILE 557

Query: 441  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD 500
             EN     T+ + R   Q      +     V+   KEN    E   +       +   K 
Sbjct: 558  QENEHLNQTVSSLRQRSQ------ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611

Query: 501  AIQRKYSCDRSSSIHKLEDLVQE--SMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 558
             I+++    +     + E+L  E   +E++ ELLQ K  I NL    + I  L+  NS+ 
Sbjct: 612  QIKKELEHYKEKG-ERAEELENELHHLEKENELLQKK--ITNLKITCEKIEALEQENSEL 668

Query: 559  PLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPP 618
              +     K +  ++ +   +       L   + +   + +    N   +      +   
Sbjct: 669  ERENRKLKKTLDSFKNLTFQLES-----LEKENSQLDEENLELRRNVESLKCASMKMAQL 723

Query: 619  NKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGE 678
              E  +L +  EQ  + +  L        +  VS+  L  E  R++ +   S K +    
Sbjct: 724  QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI---- 779

Query: 679  HQQVLSNLQS--RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEE 736
             QQ+ S LQ        L+ + E    S   + QLEKE    +Q   +L K  ++ E+E 
Sbjct: 780  -QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838

Query: 737  SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD--DLHESVFRITEQEKLKKEL-ERL 793
                   +E+++  L   N +   + +    L ++     ES  R+ E EK  KEL +R 
Sbjct: 839  KRLRQQ-AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897

Query: 794  KDDLGTITNKCEEFFSQ----AAASSSVPTLRSELNVV-LQNMNQVYSMSSTYIDKLKTV 848
              D+ T+    E+  S+       ++ +  L  EL  + L     ++   ST   + K +
Sbjct: 898  TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957

Query: 849  NLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHAL-- 906
               L++T     L K  E K   EE + A +  +E   +  +Q R E+   ++ + AL  
Sbjct: 958  ESKLEST-----LKKSLEIK---EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009

Query: 907  -EDE---LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-RWQNVHVQ-----IDNRL 956
             +DE   +Q +  IS E  K  +E         +  D+L+E    N  +Q     +  +L
Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069

Query: 957  RDLEGIGKSLK-----YYRDTYHPLDDWIQQVETTQRKIQ-ENQPENSKTLATQLNQQKM 1010
            + LE    +L+       R T   L +    ++T   K+Q EN   NS++ +      ++
Sbjct: 1070 KQLETQNNNLQAQILALQRQTV-SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128

Query: 1011 LVSEIEMK---QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1067
            L+ +  ++   +S + E +     Y + +KD+E   + +       +    K   ++S+ 
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1188

Query: 1068 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1127
              +  E  DL  RY  L+    Q      D  K L+ E++ +  E K H   A E +K  
Sbjct: 1189 KNLEVEHRDLEDRYNQLLKQKGQ----LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244

Query: 1128 S-------NISKTLKDAE------KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
                      S+ LK+ E      K  K   +  K+    +  +  +L E  Q + +   
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304

Query: 1175 KHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD---VKVEEKLDKV 1228
            K  +  ++  + +  LE++ + L +    L  ++   L+++  S D   V+  + +DK+
Sbjct: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 165/869 (18%), Positives = 364/869 (41%), Gaps = 132/869 (15%)

Query: 408  IARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467
            +  K +   +  +EL+Q E  +K +Q+    LL +   AR+    YR  +       +++
Sbjct: 267  LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM----YRDELDALREKAVRV 322

Query: 468  CQCVEQ--HIKENTAYFEFFN----DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLV 521
             +   +    KE     EF+     + KE    L   K  ++ +    R+ S  KL +L 
Sbjct: 323  DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS-DKLHELE 381

Query: 522  QESMEEKEELLQY-------KSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
            +E+++ K +L          +  I  LM +  T+   + ++ D  L     ++ I    +
Sbjct: 382  KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 575  I-------------EITIYKDDECVLANNS-----HRAKWKVISPTGNEAMVPSVCFTVP 616
            +             E+T  +  +  + N S        +  V S  GN + +  +     
Sbjct: 442  LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501

Query: 617  PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTM-L 675
              +K+   L N I Q+ Q++    + S   MK       L   I+ +R ++   IK +  
Sbjct: 502  RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ---LEKTIETLRENSERQIKILEQ 558

Query: 676  PGEH-QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQ 734
              EH  Q +S+L+ R          SQ+ + + +  +EKE  +  +  +E      + E 
Sbjct: 559  ENEHLNQTVSSLRQR----------SQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608

Query: 735  EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLK 794
            E+          R I+  LE+ +++         ER +  E+     E   L+KE E L+
Sbjct: 609  EK----------RQIKKELEHYKEK--------GERAEELEN-----ELHHLEKENELLQ 645

Query: 795  DDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM-NQVYSMSSTYIDKLKTVNLVLK 853
              +  +   CE+  +    +S +     +L   L +  N  + + S          L  +
Sbjct: 646  KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----------LEKE 695

Query: 854  NTQAAEALVKLYETKLCEEEAVIADKNNIENL-ISTLKQWRSEVDEKRQVFHALEDELQK 912
            N+Q  E  ++L              + N+E+L  +++K  + +++ K     + +++L+K
Sbjct: 696  NSQLDEENLEL--------------RRNVESLKCASMKMAQLQLENKE--LESEKEQLKK 739

Query: 913  AKAISDEMFKTYKERDLDF---DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY 969
               +    FK  +  ++ +   D   ++  + +E       Q+++ L+DLE   ++L+  
Sbjct: 740  GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799

Query: 970  RDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1029
             +        ++Q+E   + +++   +  K       + K L  + E+K + +       
Sbjct: 800  LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL------- 852

Query: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ-SSADLIIQEFMDLRTRYTALVTLM 1088
            E+ +  + + E +  T    +   ++S V+ + ++  + +L+ +  +D++T  T    L+
Sbjct: 853  EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912

Query: 1089 TQYIKF--AGDSLKRL--EEEEKSLEEEKKEHVEKAKELQKW---VSNISKTLKDAEKAG 1141
            ++ +K     + L++L  E E+  L +E+  H E++ +  ++    S +  TLK + +  
Sbjct: 913  SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK 972

Query: 1142 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1201
            +   +  +   EE +   +QL + L+T++    K+ + +  ++R + E+ V    +S   
Sbjct: 973  EEKIAALEARLEESTNYNQQLRQELKTVK----KNYEAL--KQRQDEERMV----QSSPP 1022

Query: 1202 LFSESLKQLQESQ--TSGDVKVEEKLDKV 1228
            +  E  K  +ESQ  T   +KV+++L +V
Sbjct: 1023 ISGEDNKWERESQETTRELLKVKDRLIEV 1051



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 199/1041 (19%), Positives = 408/1041 (39%), Gaps = 176/1041 (16%)

Query: 248  NSLQTLKLMQIRKPLLK---SSLLDQNLTEEEINMKFVQD----LLNWVDEMQVQLDRTE 300
            NS + +K+++     L    SSL  ++    E  +K ++     L   + E   +L + E
Sbjct: 548  NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSL----KEAKISEIQMTAPLKLTYAEKLHRLES 356
            +  +   ++  LE++K      EE E+ L    KE ++ + ++T  LK+T  EK+  LE 
Sbjct: 608  F--EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN-LKIT-CEKIEALEQ 663

Query: 357  QYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 416
            + ++L   +R  ++ LD+  N   +       L   E+E    D  E N           
Sbjct: 664  ENSELERENRKLKKTLDSFKNLTFQ-------LESLEKENSQLD--EENL---------- 704

Query: 417  ELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIK 476
                EL +  E++K       QL LEN       E  +  ++     +L+      + ++
Sbjct: 705  ----ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-----LLKASFKKTERLE 755

Query: 477  ENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKS 536
             +    +  N   + T  L N    IQ+  S        +L+DL  E+   ++ L + K 
Sbjct: 756  VSYQGLDIENQRLQKT--LENSNKKIQQLES--------ELQDLEMENQTLQKNLEELKI 805

Query: 537  TIANLMGKAKTIIQLKPRNSDCPLKTS----------IPIKAICDYRQIEITIYKDDECV 586
            +       +K + QL+  N     +TS             K +    +I+ T  +++   
Sbjct: 806  S-------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858

Query: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHIN 646
            + N     K    + +    +    C  +    KE  +L  R     + ++TL  +    
Sbjct: 859  IGNLEKENK----TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED---- 910

Query: 647  MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 706
                     L++E  +++   + +    L  E +++  N +    D  E S +   +   
Sbjct: 911  ---------LVSE--KLKTQQMNNDLEKLTHELEKIGLNKERLLHD--EQSTDDSRYKLL 957

Query: 707  DITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI-SEVRNIR-----LRLENCEDRL 760
            + ++LE  +    +  +E + + E   +E + YN  +  E++ ++     L+    E+R+
Sbjct: 958  E-SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016

Query: 761  IRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            + Q   P+  +D         E ++  +EL ++KD L  +        + A   +    L
Sbjct: 1017 V-QSSPPISGEDNKWE----RESQETTRELLKVKDRLIEVER------NNATLQAEKQAL 1065

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT--QAAEALVKLYETKLCEEEAVIAD 878
            +++L  +    N + +       + +TV+L  +NT  Q   A +++  + L  +   + +
Sbjct: 1066 KTQLKQLETQNNNLQAQILAL--QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123

Query: 879  KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKA 938
            +N        L Q  S  +E   V    ED     K++ D + K +++ +L  +    + 
Sbjct: 1124 QN-----AQLLIQQSSLENENESVIKERED----LKSLYDSLIKDHEKLELLHERQASEY 1174

Query: 939  DQLVER---WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP 995
            + L+ +    ++ H  ++   RDLE          D Y+ L     Q+E  ++ +   + 
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLE----------DRYNQLLKQKGQLEDLEKML---KV 1221

Query: 996  ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
            E  K L    N + +     ++      E  +    YS  +K+ E+    ++ +      
Sbjct: 1222 EQEKMLLENKNHETVAAEYKKL----CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1277

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKE 1115
            S +++ R+++       EF  L+ +Y  L    T+      +  + L + + +LEEE + 
Sbjct: 1278 SKLEQTRLEA-------EFSKLKEQYQQLDITSTK----LNNQCELLSQLKGNLEEENRH 1326

Query: 1116 HVEKAKELQKWVSNISKTLKDAEKAGKPPF---SKQKISS-EEISTKKEQLSEALQTIQL 1171
             +++ + L       ++TL +     K  F    +Q I    E+  +KE+L E +     
Sbjct: 1327 LLDQIQTLMLQ----NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382

Query: 1172 FL-----AKHGDKMTDEERNELEKQVKTLQESYNLL--------FSESLKQL--QESQTS 1216
            F       + G+ +T + R  ++ +    +E    L         SE   QL  Q+SQ S
Sbjct: 1383 FYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1442

Query: 1217 GDVKVEEKLDKVIAGTIDQTT 1237
              V      D    GT   +T
Sbjct: 1443 SSVGSNSLEDGQTLGTKKSST 1463



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 110/551 (19%), Positives = 227/551 (41%), Gaps = 80/551 (14%)

Query: 730  EREEQEESVYNLYISEV-----RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE 784
            E    +E+V++L   EV      +I   L+N    L R I    ERD+  E++  ++E+ 
Sbjct: 162  EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLID---ERDEHSETIIELSEER 218

Query: 785  K----LKKELERLKDDLGTITNKCEEFFSQ-----AAASSSVPTLRSELNVVLQNM---N 832
                 L       +   G+   K  E         A A + +  LR EL    + +    
Sbjct: 219  DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCK 278

Query: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ- 891
            Q        + +L+  N+ L +  A  A +   E     E+AV  DK  +E+ +S  K+ 
Sbjct: 279  QELEQMEIELKRLQQENMNLLS-DARSARMYRDELDALREKAVRVDK--LESEVSRYKER 335

Query: 892  ------WRSEVDEKRQVFHAL-------EDELQKAKAISDEMFKTYKER----------D 928
                  +++ V+E ++    L       ED+L+  +A SD++ +  KE           +
Sbjct: 336  LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395

Query: 929  LDFDWHKEKADQLVERWQNVHV----QIDNRLR---DLEGIGKSLKYYRDTYHPLDDWIQ 981
            ++ D  ++K ++L+E    + +     +D  L    +LE I ++ +        L   + 
Sbjct: 396  MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455

Query: 982  QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYEL 1041
              E T  ++ + + EN ++L   + + +  V  +E   SK+ + +K  ++ S  V+  E 
Sbjct: 456  --ELTSSRLLKLEMEN-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 1042 QTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-- 1099
            + +  +  + + Q       + ++  +  I+   +   R   ++    +++     SL  
Sbjct: 513  EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572

Query: 1100 ----------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK 1149
                      K +E+E K L E  KE   K  +++     I K L+  ++ G+     ++
Sbjct: 573  RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEE 629

Query: 1150 ISSE--EISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ----VKTLQESYNLLF 1203
            + +E   +  + E L + +  +++   K   +  ++E +ELE++     KTL    NL F
Sbjct: 630  LENELHHLEKENELLQKKITNLKITCEK--IEALEQENSELERENRKLKKTLDSFKNLTF 687

Query: 1204 SESLKQLQESQ 1214
                 + + SQ
Sbjct: 688  QLESLEKENSQ 698



 Score = 32.7 bits (73), Expect = 5.7
 Identities = 54/268 (20%), Positives = 104/268 (38%), Gaps = 24/268 (8%)

Query: 989  KIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT--- 1045
            K  E++   S  LA    + + L  E+E K  ++ +C++  EQ    +K  + + M    
Sbjct: 241  KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 1046 -------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS 1098
                   YR  +D+ ++  V+  +++S      +   D+   Y A V  + +  +   ++
Sbjct: 301  DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF-YKARVEELKEDNQVLLET 359

Query: 1099 LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEIST 1157
               LE++     E  +   +K  EL+K    +   L D E        K +++  E ++ 
Sbjct: 360  KTMLEDQ----LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415

Query: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
            +  Q     +++ L         T E     E   K+L    N L S  L +L+    S 
Sbjct: 416  EMAQKQSMDESLHLGWELEQISRTSELS---EAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSVFQ 1245
               VEE     +  T+D   G    + +
Sbjct: 473  TKTVEE-----LRTTVDSVEGNASKILK 495


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 199/1053 (18%), Positives = 416/1053 (39%), Gaps = 165/1053 (15%)

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL 372
            ++++N  + I   E  L        Q+   L  T ++K   L+    K+   ++  E H 
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSERNQLRGELD-TMSKKTTALDQLSEKMKEKTQELESHQ 1995

Query: 373  DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 432
                + +  A  E+     KE+ E+    S   + + + K +  E ++ L++  + +   
Sbjct: 1996 SECLHCIQVAEAEV-----KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050

Query: 433  Q-EIAEQLLLENHPARLTI---EAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 488
            + E+  Q+   N    L +   E+ +A +       L + + +E  + E   +    +  
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2110

Query: 489  KEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ-----ESMEEKEELLQYKSTIANLMG 543
            +E    LR   + ++ +   D    +H  E L +     +S+++K E L+ +  ++    
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE--- 2167

Query: 544  KAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTG 603
            + + ++ L   NS   ++T   +K   +     + +++ D   L +       ++    G
Sbjct: 2168 ENQELVILDAENSKAEVET---LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG 2224

Query: 604  NEAMVPSVCFT--------------VPPPNKEAVD-LANRIEQQYQNVLTLWHESHINMK 648
              + +  +  +              +   +K AV+ L N++++  + V  L  +  I   
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284

Query: 649  SVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDI 708
            +  S    I E  ++R S +  ++  L  + ++ L  LQ      L++S+         +
Sbjct: 2285 TEQSLDPPIEEEHQLRNS-IEKLRARLEADEKKQLCVLQQ-----LKESEHHADLLKGRV 2338

Query: 709  TQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPL 768
              LE+E+ + +   +     AE  +           EV  ++ ++E     L       L
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSK----------GEVETLKAKIEGMTQSL-----RGL 2383

Query: 769  ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVL 828
            E D +     +     +L+KE ER+ + L  I +  E    +                  
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISE-LEIINSSFENILQEKE---------------- 2426

Query: 829  QNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST 888
            Q   Q+   SST ++ L+T    L    AA     L+     ++EA  A + N+ + +  
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAA-----LHN----DQEACKAKEQNLSSQVEC 2477

Query: 889  LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
            L+       EK Q+   L++       +   +    +E + D     EK D+ + R +N 
Sbjct: 2478 LEL------EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE-DGKQKLEKKDEEISRLKNQ 2530

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
                +  +  L  +    + +++    L +   ++E   + +Q        TL    +  
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY 2590

Query: 1009 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD 1068
            K L +E+E+  +KMD+     +    T K+ ELQ    R M +  QK+   +  +     
Sbjct: 2591 KNLENELEL--TKMDKMSFVEKVNKMTAKETELQ----REMHEMAQKTAELQEELSGE-- 2642

Query: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKELQ 1124
                     + R    + L+ + IK + D LK L     E +KSL+   K+ VEK  +++
Sbjct: 2643 ---------KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693

Query: 1125 KWVSNISKTLKDAEK-------------------------AGKPPFSKQKISSEEISTKK 1159
            + ++     L +AEK                         + +   S QK+  + + + K
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753

Query: 1160 EQLSEALQ-TIQLFLAKHGDKMTD-EERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1217
            E+L+ +L+ T Q+       KM + +  N+L+K+ +  Q    LL  +S KQL+E +   
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI-KSCKQLEEEKEI- 2811

Query: 1218 DVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRK 1277
               ++++L ++ A    Q TG V+             DT +  L T++        EL++
Sbjct: 2812 ---LQKELSQLQAAQEKQKTGTVM-------------DTKVDELTTEI-------KELKE 2848

Query: 1278 CFDLKDAKSHGLIDE--QILCQLKELSKAKEII 1308
              + K  ++   +D+   +L   ++L KAKE++
Sbjct: 2849 TLEEKTKEADEYLDKYCSLLISHEKLEKAKEML 2881



 Score = 65.5 bits (158), Expect = 8e-10
 Identities = 205/1036 (19%), Positives = 417/1036 (40%), Gaps = 144/1036 (13%)

Query: 254  KLMQIRKPLLKSSLLDQNLTEEEINMKF-----VQDLLNWVDEMQVQLDRTEWGSDLPSV 308
            K  + ++ L +     Q L +E I MK      +Q   N  + +Q +LD+      L SV
Sbjct: 392  KEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK------LTSV 445

Query: 309  ESHLENH-----KNVHRAIEEFESS-LKEAKI----SEIQMTAPLKLTYAEKLHRLESQY 358
            +  LEN+     + + RA + F++S +KE ++     E++    L  +++E+  R   + 
Sbjct: 446  KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR---EV 502

Query: 359  AKLLNTSRNQERHLDTLHNFV----SRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY 414
              L    +N ++ L+   NF     ++ T++   L + +E+    +  E +  + + K  
Sbjct: 503  CHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK---INQQENSLTLEKLKLA 559

Query: 415  HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 474
             A+L ++ D  ++ +K  +   EQL   N     T +  +A +       L+L +   + 
Sbjct: 560  VADLEKQRDCSQDLLKKREHHIEQL---NDKLSKTEKESKALLSA-----LELKKKEYEE 611

Query: 475  IKENTAYFEFFNDAKEAT-----DYLRNLKDAIQRKYSCDRSSSI--HKLEDLVQESMEE 527
            +KE    F  +    E           NL+  I    +C ++  I  H+  + V+    +
Sbjct: 612  LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD 671

Query: 528  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587
            +E L      + N++      ++ + + +   L+           ++IE    K  +   
Sbjct: 672  RENLSVEIRNLHNVLDSKSVEVETQ-KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730

Query: 588  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647
                   K +++S   NE M    C+     + E   L + ++ +  +++T  +E H   
Sbjct: 731  QVEDLEHKLQLLS---NEIMDKDRCYQ--DLHAEYESLRDLLKSKDASLVT--NEDH--Q 781

Query: 648  KSVVSW-------HYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQES 700
            +S++++       H   N I    +      +  L  +     S +     D LE S ES
Sbjct: 782  RSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLES 841

Query: 701  QVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRL 760
            Q    SD+ +  +E+   K   +E L  AE+  Q       +++E      +L+      
Sbjct: 842  QKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQS------FVAETSQRISKLQ------ 889

Query: 761  IRQIRTPLERDDLHESVF--RITEQEKLKKELERLKDDLGTITNKCEEFFSQ----AAAS 814
                    E    H++V    ++  E  +KEL+ L D + T   + +E          + 
Sbjct: 890  --------EDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
              +  L   L++  + M+ + S++   I++L   N  LK   A+     L + K+     
Sbjct: 942  KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS-----LNQEKM----- 991

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKERDLD 930
                     NLI   + + + +DE+ +    L D+ ++ K I     +E    Y++    
Sbjct: 992  ---------NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK 1042

Query: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPL-------DDWIQQ 982
            +   +EK  +L           +NR  +LE + ++  K +++    L        + + +
Sbjct: 1043 YKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLE 1102

Query: 983  VETTQRKIQENQPE---NSKTLATQLNQQKMLVSEIEMK-QSKMDECQKYAEQYSATVK- 1037
            +ET Q+ ++    +   NSK+ A  L Q+ M + E + K Q ++++  +  EQ    +K 
Sbjct: 1103 LETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKT 1162

Query: 1038 DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD 1097
             +E Q +    + +S ++   +R +         +  MDL  +  +L +   Q ++    
Sbjct: 1163 KHECQNLESEPIRNSVKERESERNQCN------FKPQMDLEVKEISLDSYNAQLVQLEA- 1215

Query: 1098 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI-SKTLKDAEKAGKPPFSKQKISSEE-- 1154
                L  +E  L+E +KE      ELQ    ++ +  L+D +          +I +EE  
Sbjct: 1216 ---MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKY 1272

Query: 1155 ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ-ESYNLLFSESLKQLQES 1213
            IS   E  +       L  +    + T  + NELEK  + LQ E Y L+    L   +  
Sbjct: 1273 ISGPHELSTSQNDNAHLQCSL---QTTMNKLNELEKICEILQAEKYELV--TELNDSRSE 1327

Query: 1214 QTSGDVKVEEKLDKVI 1229
              +   K+ E++ K++
Sbjct: 1328 CITATRKMAEEVGKLL 1343



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 164/888 (18%), Positives = 350/888 (39%), Gaps = 191/888 (21%)

Query: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
            +K+  LE Q  KL    + ++  LD+L   + +   ++   NEK E           TN+
Sbjct: 18   QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--NEKTE----------GTNL 65

Query: 409  ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLC 468
             R+     E+   L+      K+ Q+I+ +L ++               + Q +   +  
Sbjct: 66   KRENQRLMEICESLE------KTKQKISHELQVKESQVNF--------QEGQLNSGKKQI 111

Query: 469  QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIH----KLEDLVQES 524
            + +EQ +K   +  E    A ++ D   N  +  Q+ ++   + S +    K EDL ++ 
Sbjct: 112  EKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171

Query: 525  MEEKEELLQYKSTIANLMGK--AKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKD 582
             +E EE  + ++ +  L  K  ++T+ Q    + D     +    ++  ++Q +   +  
Sbjct: 172  NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQAS--SSVFSWQQEKTPSH-- 227

Query: 583  DECVLANNSHRAK----WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLT 638
                L++NS R      +     +G + + PS         +  + +  R          
Sbjct: 228  ----LSSNSQRTPIRRDFSASYFSGEQEVTPS---------RSTLQIGKRDA-------- 266

Query: 639  LWHESHINMKSVVSWHYLINEIDRIRASN------VASIKTMLPGEHQQVLSNLQSRFED 692
              + S  +  S  S H L    D+++A N      +  ++  L G H++ +    ++F++
Sbjct: 267  --NSSFFDNSS--SPHLL----DQLKAQNQELRNKINELELRLQG-HEKEMKGQVNKFQE 317

Query: 693  FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR 752
                 ++++V    ++ + EK +N C+    EL+++  + +Q  + Y     +++ +   
Sbjct: 318  LQLQLEKAKV----ELIEKEKVLNKCRD---ELVRTTAQYDQASTKYTALEQKLKKLTED 370

Query: 753  LENCEDRLIRQIRTPLERDDLHESVFRITEQEK-LKKELERLKDDLGTITNKCEEFFSQA 811
            L +C+ +     R  LE+        +I E+EK  ++EL R +    T+  +C +     
Sbjct: 371  L-SCQRQNAESARCSLEQ--------KIKEKEKEFQEELSRQQRSFQTLDQECIQ----- 416

Query: 812  AASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE 871
                    +++ L   LQ    ++++    +DKL +V                       
Sbjct: 417  --------MKARLTQELQQAKNMHNVLQAELDKLTSV----------------------- 445

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931
                   K  +EN +   KQ     ++  Q     E+EL+++      M +  KE +L  
Sbjct: 446  -------KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS------MEEMKKENNLLK 492

Query: 932  DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
               ++KA ++       H++      +L+ I + L   ++    +       ET  R +Q
Sbjct: 493  SHSEQKAREV------CHLE-----AELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ 541

Query: 992  E--NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1049
            E  NQ ENS T    L + K+ V+++E ++    +  K  E +                +
Sbjct: 542  EKINQQENSLT----LEKLKLAVADLEKQRDCSQDLLKKREHH-------------IEQL 584

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT----------ALVTLMTQYIKFAGDSL 1099
             D   K+  + + + S+ +L  +E+ +L+   T           L+T M    +     +
Sbjct: 585  NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644

Query: 1100 KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
              LE   K+ + +  E+ E+ + L+    N+S  +++               S E+ T+K
Sbjct: 645  NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNV-------LDSKSVEVETQK 697

Query: 1160 EQLSEALQTIQLFLAKHGDKMTDE--ERNELEKQVKTLQESYNLLFSE 1205
                E  Q  +    KH  ++ +   + ++L  QV+ L+    LL +E
Sbjct: 698  LAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 192/1071 (17%), Positives = 417/1071 (38%), Gaps = 133/1071 (12%)

Query: 256  MQIRKPLLKSSLLDQNLTEEEINMKFVQ--DLLNWVDEMQVQLDRTEWGSDLPSVESHLE 313
            +QI K    SS  D + +   ++    Q  +L N ++E++++L            + H +
Sbjct: 259  LQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL------------QGHEK 306

Query: 314  NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 373
              K      +E +  L++AK+  I+    L     ++L R  +QY +        E+ L 
Sbjct: 307  EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC-RDELVRTTAQYDQASTKYTALEQKLK 365

Query: 374  TLHNFVS----RATNELIWLNEK---EEEEVAYDWSERNTNIARKKDYHAELMRELDQKE 426
             L   +S     A +    L +K   +E+E   + S +  +         ++   L Q+ 
Sbjct: 366  KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL 425

Query: 427  ENIKSVQEIAEQLL---------LENHPARLTIEAYRAAMQTQWSWILQ--LCQCVEQHI 475
            +  K++  + +  L         LEN+      +  RA    Q S I +  L + +E+  
Sbjct: 426  QQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMK 485

Query: 476  KENTAYFEFFND-AKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM--EEKEELL 532
            KEN          A+E       LK+  Q        +   K ++  QE+M  + +E++ 
Sbjct: 486  KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN 545

Query: 533  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD-ECVLANNS 591
            Q ++++   + K K  +    +  DC     +  K      Q+   + K + E     ++
Sbjct: 546  QQENSLT--LEKLKLAVADLEKQRDC--SQDLLKKREHHIEQLNDKLSKTEKESKALLSA 601

Query: 592  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 651
               K K       E  + S C+       E   L  ++E + +N+ +  +     +K+  
Sbjct: 602  LELKKKEYEELKEEKTLFS-CW-----KSENEKLLTQMESEKENLQSKINHLETCLKTQQ 655

Query: 652  SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVFSGSDI 708
               +  NE  R    +  ++   +   H  + S    ++++   ++E  Q+++    SD 
Sbjct: 656  IKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF---SDQ 712

Query: 709  TQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVR---NIRLRLENCEDRLIRQIR 765
               ++  N+C +  Q   +  + E + + + N  + + R   ++    E+  D L  +  
Sbjct: 713  KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772

Query: 766  TPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK---CEEFFSQAAASSSVPTLRS 822
            + +  +D   S+    +Q  +      +  + G++ ++   C     Q+  +S++   R 
Sbjct: 773  SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832

Query: 823  E-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-------------QAAEALVKLYETK 868
            + L   L++  Q+ S      ++L  +   ++               + ++ + KL E  
Sbjct: 833  DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892

Query: 869  LCEEEAVIADKNNIEN-------LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF 921
               +  V    + +EN       L   ++  ++E+ E ++  H LED L++ + +S+ + 
Sbjct: 893  SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952

Query: 922  KTYKERDLDFDWHKEKADQLVER---WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDD 978
               KE       +K + ++L +     + ++  ++    +L    +S   Y D       
Sbjct: 953  LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012

Query: 979  WIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK-QSKMDECQKYAEQYSATVK 1037
             +      ++ I   + E +      L+Q+     E   K +  ++EC    E      +
Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCEN-----R 1067

Query: 1038 DYELQTMTYRAMVDSQQ---KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1094
              EL+ +      + Q+   K      R Q+         ++L T   AL + MT     
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNL-------MLELETVQQALRSEMT----- 1115

Query: 1095 AGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEE 1154
              D+    + E   L++E     E+  ++QK V+++ +  +   K  K     Q + SE 
Sbjct: 1116 --DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP 1173

Query: 1155 I-STKKEQLSEA----------LQTIQLFLAKHGDKMTDEE---RN------ELEKQVKT 1194
            I ++ KE+ SE           L+  ++ L  +  ++   E   RN      E EK+ + 
Sbjct: 1174 IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC 1233

Query: 1195 LQESYNL----LFSESLKQLQESQTSG--DVKVEEKLDKVIAGTIDQTTGE 1239
            LQ         L + +L+ +Q  + SG  D +++ + +K I+G  + +T +
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAE-EKYISGPHELSTSQ 1283



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 107/564 (18%), Positives = 227/564 (40%), Gaps = 90/564 (15%)

Query: 876  IADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHK 935
            + ++ +I NL   +K+  +E     ++ H +ED  +K +++ +EM      ++LD   H 
Sbjct: 1763 LGNQEDIHNLQLRVKETSNE---NLRLLHVIEDRDRKVESLLNEM------KELDSKLHL 1813

Query: 936  EKADQL--VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993
            ++   +  +E    +   +    ++   + + L+Y+   +  L   +Q+VET++      
Sbjct: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL---LQRVETSE------ 1864

Query: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQ 1053
                       LN    + ++   ++   D   K  + +     D E +    R+     
Sbjct: 1865 ----------GLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRS----- 1909

Query: 1054 QKSPVKRRRMQSSADLIIQEF------MDLRTRYTALVTLMTQYIKFAGD------SLKR 1101
            +K+ ++   +   ADL + +        D   +   +V L  +      +       L  
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT 1969

Query: 1102 LEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS-KQKISSE--EISTK 1158
            + ++  +L++  ++  EK +EL+   S     ++ AE   K      Q +SS+  E+   
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029

Query: 1159 KEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1218
            K  L E LQ+++        +     + ELE Q+  L +   LL  ES + LQ   +  D
Sbjct: 2030 KTHLQEKLQSLE-----KDSQALSLTKCELENQIAQLNKEKELLVKES-ESLQARLSESD 2083

Query: 1219 ---VKVEEKLDKVI------AGTIDQTTGEVLSVFQAV--LRGLIDYDTGIRLLETQLMI 1267
               + V + L+  +      A  +  T  EV  + + +  LR  I+ D      + QL I
Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE-----KKQLHI 2138

Query: 1268 SGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMI 1327
            +  +    R+   LKD        E +  +L+   + +E++   +  +   ++ L   + 
Sbjct: 2139 AEKLKERERENDSLKDKV------ENLERELQMSEENQELVILDAENSKAEVETLKTQIE 2192

Query: 1328 TESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS-----ALFSKVLERQNMCKD 1382
              + ++KV E+ L T    + +  E LT Q   +Q  +S      + F  +LE +   + 
Sbjct: 2193 EMARSLKVFELDLVT----LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248

Query: 1383 LIDPCTSEKVSLIDMVQRSTLQEN 1406
             I     E  + ++M+Q    + N
Sbjct: 2249 QI---KEESKTAVEMLQNQLKELN 2269



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 107/561 (19%), Positives = 212/561 (37%), Gaps = 88/561 (15%)

Query: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731
            K  LP    Q +  L+ + +   ++ Q+ Q      +  LE  +   KQ         E 
Sbjct: 9    KEGLPTRALQKIQELEGQLDKLKKEKQQRQF----QLDSLEAALQKQKQ-------KVEN 57

Query: 732  EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ--EKLKKE 789
            E+ E +        +  I   LE  + ++  +++    + +  E      ++  EKL++E
Sbjct: 58   EKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117

Query: 790  LERLKDDLGTITNKCEEFFSQAAASSSVP----TLRSELNVVLQNMNQVYSMSSTYIDKL 845
            L+R K +L        E   QAA S+ V         ++       +Q YS  S Y D  
Sbjct: 118  LKRCKSEL--------ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS-GSKYEDLK 168

Query: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE----NLISTLKQWRSEVDEKRQ 901
            +  N  ++  +  EA VK  + K   +    A  N+ +       S++  W+ E      
Sbjct: 169  EKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE------ 222

Query: 902  VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
                     +    +S    +T   RD    +   + +    R     +QI  R  +   
Sbjct: 223  ---------KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRST---LQIGKRDANSSF 270

Query: 962  IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE---NSKTLATQLNQQKMLVSEIEMK 1018
               S      + H LD    Q +  + KI E +     + K +  Q+N+ + L  ++E  
Sbjct: 271  FDNS-----SSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKA 325

Query: 1019 QSKMDECQKYA----EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
            + ++ E +K      ++   T   Y+  +  Y A+    +K          + DL  Q  
Sbjct: 326  KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL---------TEDLSCQR- 375

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLK-RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT 1133
                           Q  + A  SL+ +++E+EK  +EE        + L +    +   
Sbjct: 376  ---------------QNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR 420

Query: 1134 LKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQ--LFLAKHGDKMTDEERNELEKQ 1191
            L    +  K   +  +   +++++ K+QL   L+  +  L  A+   + +  + NEL + 
Sbjct: 421  LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS 480

Query: 1192 VKTLQESYNLLFSESLKQLQE 1212
            ++ +++  NLL S S ++ +E
Sbjct: 481  MEEMKKENNLLKSHSEQKARE 501



 Score = 37.7 bits (86), Expect = 0.18
 Identities = 184/934 (19%), Positives = 344/934 (36%), Gaps = 153/934 (16%)

Query: 2097 DCLHPEDYDTLQEE--NDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDF 2154
            +C   +  DT  E    D+T   ++   ++S    N++VP    +  L  +   H LQ  
Sbjct: 1720 ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVP----MDFLGNQEDIHNLQLR 1775

Query: 2155 LMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKE 2214
            + +       S E + L  V  D+           +E  + L   E   +T  +     E
Sbjct: 1776 VKET------SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829

Query: 2215 SFTASLKFDDSGSWRGRKEEYV------------TGQEFHSDTDHLDSMQSEESYGDYIY 2262
                 LK ++S      K EY             T +  +SD +      S E  GD + 
Sbjct: 1830 KIVGELKKENSDL--SEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVA 1887

Query: 2263 DSNDQDDDDDDGIDEEGGGIRDENG--KPRCQNVAEDMDIQLCASILNENSDENENINTM 2320
              ND   +    ++ E   IR E    +     +  D+++     +  E  +EN+    +
Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQ-KVI 1946

Query: 2321 ILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENL------- 2373
            + L++  S  + E+ Q    +   S     L      + E T E+     E L       
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006

Query: 2374 --LNHEMVLKDVLPPIIKDTESEKTF---GPASISHDNNNISSTS-ELGTDLAN-TKVKL 2426
              +  +  L   L   + +   +KT       S+  D+  +S T  EL   +A   K K 
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066

Query: 2427 IQGSELPELTDSVKGKDEYFKNMTPKVDSSLD-------HIICTEPDL--IGKPAEESHL 2477
            +   E   L   +   D    N++  ++++L         +  T+ ++  + +  E+  +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV 2126

Query: 2478 SLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLK 2537
             + A   D+  Q + ++ +K R+ ++D L +   ++++          E  + EEN+ L 
Sbjct: 2127 RIEA---DEKKQLHIAEKLKERERENDSLKDKVENLER----------ELQMSEENQELV 2173

Query: 2538 LLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQF 2597
            +L  +N++   + + +Q         E        +   VTL+ E  NL   + +   Q 
Sbjct: 2174 ILDAENSKAEVETLKTQI-------EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQL 2226

Query: 2598 ENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAK 2657
              L+++  +  S     +        E  T  E        KEL+     +  A     +
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVE--MLQNQLKELN-----EAVAALCGDQ 2279

Query: 2658 DVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKESI- 2716
            ++ K  E          PP++E  QL  N+ ++     + D       +   LC  + + 
Sbjct: 2280 EIMKATEQ------SLDPPIEEEHQLR-NSIEKLRARLEAD-------EKKQLCVLQQLK 2325

Query: 2717 -SGGGTEISQFTPESIEATLSI--LSRKHVEDVGKNDFLQSERC-ANGLGNDNSSNTLNT 2772
             S    ++ +   E++E  L I   +++H     +N   + E   A   G   S   L  
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL 2385

Query: 2773 DYSFLEINNKKERIEQQLPKEQ---------------ALSPRSQEKEVQIPELSQVFVED 2817
            D   + I ++KE +  +L KEQ                L  + QEK VQ+ E S   +E 
Sbjct: 2386 D--VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK-VQMKEKSSTAME- 2441

Query: 2818 VKDILKSRLKEGHMNPQEV-EEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQ--- 2873
               +L+++LKE +     +  +  AC   K   QNL  ++   +L         D     
Sbjct: 2442 ---MLQTQLKELNERVAALHNDQEAC---KAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495

Query: 2874 ----MSDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHS-----QKITGV 2924
                 S  +G+       + K E +D+   I  LK+++      QDQ        ++ G 
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEE--ISRLKNQI------QDQEQLVSKLSQVEGE 2547

Query: 2925 FELMRELTHMEYDLEKRGIT----SKVLPLQLEN 2954
             +L +     E +LE R +T     K+  LQ +N
Sbjct: 2548 HQLWK-----EQNLELRNLTVELEQKIQVLQSKN 2576



 Score = 33.9 bits (76), Expect = 2.5
 Identities = 32/197 (16%), Positives = 90/197 (45%), Gaps = 12/197 (6%)

Query: 678  EHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEES 737
            +HQ +L +   ++E  ++  +E        ++  + E+++ K   +EL  S +   Q   
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ--- 2765

Query: 738  VYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDL 797
                 + E++  + +++N   + + Q++   ER      +  I   ++L++E E L+ +L
Sbjct: 2766 ----ILEELK--KTKMDNL--KYVNQLKKENERAQGKMKLL-IKSCKQLEEEKEILQKEL 2816

Query: 798  GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857
              +    E+  +     + V  L +E+  + + + +    +  Y+DK  ++ +  +  + 
Sbjct: 2817 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEK 2876

Query: 858  AEALVKLYETKLCEEEA 874
            A+ +++     LC +++
Sbjct: 2877 AKEMLETQVAHLCSQQS 2893


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score = 83.2 bits (204), Expect = 4e-15
 Identities = 178/1009 (17%), Positives = 395/1009 (39%), Gaps = 125/1009 (12%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            L+L++ R+  L+ +L  Q + +E   M ++ D   W+DEM+V +   ++G  L  VE  L
Sbjct: 501  LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 554

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 360
            + H  V     E +  ++  ++  +  +A    T  E            ++  +E  Y +
Sbjct: 555  QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 609

Query: 361  LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 417
            L   +  +   L+    L  F      E  W+ EKE+   + D+ +  T++ R    H  
Sbjct: 610  LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 669

Query: 418  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477
               E+  +  + +   +  E ++ E H     I      ++ QW+ + QL    ++ ++E
Sbjct: 670  FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 729

Query: 478  NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 537
             +   +F  DA +   ++ ++   +    S D     +  + LV++  +  EE+  Y+ T
Sbjct: 730  ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 786

Query: 538  IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 583
            +  L  +A  + Q              ++ R  +    T +  +A+ D   +     + D
Sbjct: 787  LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 846

Query: 584  ECVL--------ANNSH-----------RAKWKVISPTGNE-----AMVPSVC----FTV 615
             C L         NN             + +++ + P  N      A+V  +      + 
Sbjct: 847  ACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSG 906

Query: 616  PPPNKE---AVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR-IRASNVASI 671
             P  KE     D  N    Q++ ++    ++ ++  S+ ++H   NE    IR       
Sbjct: 907  HPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 966

Query: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE-----LL 726
             T   G     +  LQ +    L   +   V   + ++ L+KE    +  + +     L 
Sbjct: 967  STQDLGNDLAGVMALQRK----LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1022

Query: 727  KSAE----REEQEESVYN--LYISEVRNIRLRLENCED--RLIRQIRTPLERDD----LH 774
            + AE     EE + ++ N    + E   ++  L + +D    + + +T +  +D    L 
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLT 1082

Query: 775  ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 834
            E+   +T+ E +K E++  ++D   + +   E  +Q    +    LR  L  +    N++
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRD-MGEMVTQGQTDAQYMFLRQRLQALDTGWNEL 1141

Query: 835  YSM---SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
            + M       + +       L++T+ AEA +   E  L   E           + +TL+ 
Sbjct: 1142 HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-----------MPTTLEG 1190

Query: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
              + + ++      ++   +K  A+ +   +   + +++ D  +EK D + +R +     
Sbjct: 1191 AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1250

Query: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
                L  L+   + L+ +      L  WI +   T    Q+   + ++ L ++  + +  
Sbjct: 1251 ASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLT---AQDMSYDEARNLHSKWLKHQAF 1306

Query: 1012 VSEIEMKQSKMDECQKYAEQY-------SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1064
            ++E+   +  +D+ +K   Q         A VK+          +++S  ++  +R    
Sbjct: 1307 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1366

Query: 1065 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD--SLKRLEEEEKSLEEEKKEHVEKAKE 1122
            + A+L  Q   DL  ++   +    Q   +  D  S+  L ++++ LE + +   ++ +E
Sbjct: 1367 NKAELFTQSCADL-DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE 1425

Query: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1171
            LQ     +S+  K  ++      + Q    E +    E+    L + ++
Sbjct: 1426 LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEI 1474



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 242/1280 (18%), Positives = 497/1280 (38%), Gaps = 158/1280 (12%)

Query: 259  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 318
            +K L ++SLL Q   + +    ++ D+L  V    V       G D  S +S ++ HK+V
Sbjct: 724  KKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV-------GHDEYSTQSLVKKHKDV 776

Query: 319  HRAIEEFESSLKEAKISEIQMTAPLKLTYAE------KLHRLESQYAKLLNTSRNQERHL 372
               I  +  +L        +  + L   +AE      +L  +E +Y ++   +R +++ L
Sbjct: 777  AEEIANYRPTLDTLH----EQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQAL 832

Query: 373  D---TLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENI 429
                 L+   S A    +W++EKE+        E+  ++   +     L  E++ +   +
Sbjct: 833  QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 892

Query: 430  KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAK 489
              V +IA QL+   HP+   I+A +  + T+WS   +L    +  +    +   +  +  
Sbjct: 893  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 952

Query: 490  EATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
            E   ++R     I+     D  + +  +  L ++    + +L+  ++ +++L  +A+ + 
Sbjct: 953  ETKSWIREKTKVIESTQ--DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE 1010

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW--------KVISP 601
               P  +   L     I  + +  +   T  K+ E  L   S   ++          +S 
Sbjct: 1011 SEHPDQAQAILSRLAEISDVWEEMK---TTLKNREASLGEASKLQQFLRDLDDFQSWLSR 1067

Query: 602  TGNEAMVPSVCFTVPPPNK---EAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLIN 658
            T        +  T+    K   +  ++ N I+   ++   +     +  +      Y+  
Sbjct: 1068 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1127

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 718
               R++A +    +     E++Q L +    ++ FL D+++++ F  +      +E  + 
Sbjct: 1128 R-QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNN------QEYVLA 1180

Query: 719  KQYYQELLKSAER--EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES 776
                   L+ AE   ++QE+ +  +  +E + I   +E    RL+      +  D + E 
Sbjct: 1181 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEK-INAVVETGR-RLVSDGN--INSDRIQEK 1236

Query: 777  VFRITEQEKLKKE-----LERLKD--DLGTITNKCEEFF------SQAAASSSVPTLRSE 823
            V  I ++ +  +E     L RLKD  DL      C+E           A   S    R+ 
Sbjct: 1237 VDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNL 1296

Query: 824  LNVVLQNMNQVYSMSST--YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 881
             +  L++   +  ++S   ++DK++   + L + +              E EAV+ +K  
Sbjct: 1297 HSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP-------------ETEAVVKEK-- 1341

Query: 882  IENLISTLKQWR---SEVDEKRQ-VFHALEDEL-QKAKAISDEMFKTYKERDLDFDWHKE 936
               L    K W    S    K Q +F A + EL  ++ A  D+     + +    D+ K+
Sbjct: 1342 ---LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKD 1398

Query: 937  --KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
                + L+++ Q +  Q++ R +++E +    +         D+   +  T Q K  E  
Sbjct: 1399 LTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFME-- 1456

Query: 995  PENSKTLATQLNQQKM-LVSEIEMKQSKMD---ECQKYAEQYS-ATVKDYELQTMTYRAM 1049
                  L   LN++K  L++  E+ Q   D   E     E+   AT  D+     T + +
Sbjct: 1457 ------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLL 1510

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVT-----LMTQYIKFAGDSLKRLEE 1104
            +   Q    + +  Q   D I +   ++ T  ++L        +    +  G  ++  E+
Sbjct: 1511 IKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEK 1570

Query: 1105 EEKSLEEEKK--EHVEKAKELQKWVSNISKTLKDAEKAGKPP-----FSKQKISSEEIST 1157
              + LEE  +  ++   A E + W+S     +   EKA           K +I  + +  
Sbjct: 1571 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED 1630

Query: 1158 KKEQLSEALQTIQLFLA-KHGDK----MTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1212
              E + +  +T +  +A  H +     M   + ++L   +K L E       E  +  Q 
Sbjct: 1631 YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQL 1690

Query: 1213 SQTSGDVKVEEKLDKVIAGTIDQTTG-EVLSVFQAVLRGLIDYDTG---------IRLLE 1262
            ++   D++      +V+AG+ +     E +++ Q   R     DTG         +  L 
Sbjct: 1691 NREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFAR-DTGNIGQERVDTVNHLA 1749

Query: 1263 TQLMISGLISPELRKCFDLKDAKSHGLID--------EQILCQLKELSK----AKEIISA 1310
             +L+ SG    +     + KD  +    D         QIL    EL K    AKEI   
Sbjct: 1750 DELINSG--HSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1807

Query: 1311 ASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
                   + + L +   T    ++ L+ + +T    I A G Q+   +     L ++   
Sbjct: 1808 IQDKHKKLPEELGRDQNT----VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG 1863

Query: 1371 SK---VLERQNMC----KDLIDPCTSEKVSLIDMVQR---STLQENTGMWLLPVRPQEGG 1420
             K   + +R+N      K L+D C S +V L+D   +    ++  +  +W+  V  Q   
Sbjct: 1864 DKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1923

Query: 1421 RITLKCGRNISILRAAHEGL 1440
            +   +   ++ +L   H+G+
Sbjct: 1924 QEKPRDVSSVELLMNNHQGI 1943



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)

Query: 267 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
           +LD  +  E++  K+     DLL W+++  + L+  ++ + L  V+  L+   N +R +E
Sbjct: 280 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 338

Query: 324 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 383
           +     ++  +  +  T   K+    +   +  +   + + ++  ER     H       
Sbjct: 339 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 398

Query: 384 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 422
           NELI   + E+    +D        W   N  +  + ++             H  +  ++
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 458

Query: 423 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 482
              EE +++V  +A +L  EN+     I A +  +   W ++L+L +   Q ++ N    
Sbjct: 459 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 518

Query: 483 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 523
           + F +     D++  +K  +    S D    +  +EDL+Q+
Sbjct: 519 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 556



 Score = 40.8 bits (94), Expect = 0.021
 Identities = 67/336 (19%), Positives = 141/336 (41%), Gaps = 52/336 (15%)

Query: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF----DWHKEKADQL- 941
            +T+ +W+  ++E       L D   +  A S E+ K Y +    F    D HK+  ++L 
Sbjct: 1761 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1820

Query: 942  -----VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 996
                 VE  Q +H   ++   D++ +G  ++  ++    L     Q      K  + Q  
Sbjct: 1821 RDQNTVETLQRMHTTFEH---DIQALGTQVRQLQEDAARL-----QAAYAGDKADDIQKR 1872

Query: 997  NSKTLATQLNQQKMLVSEIEMKQSKM-DECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
             ++ L       K L+   E ++ ++ D   K+  ++ + V+D  L        +++Q+K
Sbjct: 1873 ENEVLEAW----KSLLDACESRRVRLVDTGDKF--RFFSMVRDLMLWMEDVIRQIEAQEK 1926

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKR-------LEEEEKS 1108
                  R  SS +L++     ++    A     T  I+     L R       ++E+   
Sbjct: 1927 P-----RDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1981

Query: 1109 LEEEKKEHVEKAKELQKW---VSNISKTLKDAEKA-----GKPPFSKQKISSEEISTKKE 1160
            L E++KE ++K ++  +W   +  + +  +DA  A     G+ P+    +SS EI    +
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPY----LSSREIGQSVD 2037

Query: 1161 QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
            ++ + ++  + F        T +ER    +++ TL+
Sbjct: 2038 EVEKLIKRHEAF---EKSAATWDERFSALERLTTLE 2070


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 83.2 bits (204), Expect = 4e-15
 Identities = 178/1009 (17%), Positives = 395/1009 (39%), Gaps = 125/1009 (12%)

Query: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
            L+L++ R+  L+ +L  Q + +E   M ++ D   W+DEM+V +   ++G  L  VE  L
Sbjct: 514  LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 567

Query: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 360
            + H  V     E +  ++  ++  +  +A    T  E            ++  +E  Y +
Sbjct: 568  QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 622

Query: 361  LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 417
            L   +  +   L+    L  F      E  W+ EKE+   + D+ +  T++ R    H  
Sbjct: 623  LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 682

Query: 418  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477
               E+  +  + +   +  E ++ E H     I      ++ QW+ + QL    ++ ++E
Sbjct: 683  FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 742

Query: 478  NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 537
             +   +F  DA +   ++ ++   +    S D     +  + LV++  +  EE+  Y+ T
Sbjct: 743  ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 799

Query: 538  IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 583
            +  L  +A  + Q              ++ R  +    T +  +A+ D   +     + D
Sbjct: 800  LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 859

Query: 584  ECVL--------ANNSH-----------RAKWKVISPTGNE-----AMVPSVC----FTV 615
             C L         NN             + +++ + P  N      A+V  +      + 
Sbjct: 860  ACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSG 919

Query: 616  PPPNKE---AVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR-IRASNVASI 671
             P  KE     D  N    Q++ ++    ++ ++  S+ ++H   NE    IR       
Sbjct: 920  HPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979

Query: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE-----LL 726
             T   G     +  LQ +    L   +   V   + ++ L+KE    +  + +     L 
Sbjct: 980  STQDLGNDLAGVMALQRK----LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1035

Query: 727  KSAE----REEQEESVYN--LYISEVRNIRLRLENCED--RLIRQIRTPLERDD----LH 774
            + AE     EE + ++ N    + E   ++  L + +D    + + +T +  +D    L 
Sbjct: 1036 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLT 1095

Query: 775  ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 834
            E+   +T+ E +K E++  ++D   + +   E  +Q    +    LR  L  +    N++
Sbjct: 1096 EAEKLLTQHENIKNEIDNYEEDYQKMRD-MGEMVTQGQTDAQYMFLRQRLQALDTGWNEL 1154

Query: 835  YSM---SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
            + M       + +       L++T+ AEA +   E  L   E           + +TL+ 
Sbjct: 1155 HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-----------MPTTLEG 1203

Query: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
              + + ++      ++   +K  A+ +   +   + +++ D  +EK D + +R +     
Sbjct: 1204 AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1263

Query: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
                L  L+   + L+ +      L  WI +   T    Q+   + ++ L ++  + +  
Sbjct: 1264 ASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLT---AQDMSYDEARNLHSKWLKHQAF 1319

Query: 1012 VSEIEMKQSKMDECQKYAEQY-------SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1064
            ++E+   +  +D+ +K   Q         A VK+          +++S  ++  +R    
Sbjct: 1320 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1379

Query: 1065 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD--SLKRLEEEEKSLEEEKKEHVEKAKE 1122
            + A+L  Q   DL  ++   +    Q   +  D  S+  L ++++ LE + +   ++ +E
Sbjct: 1380 NKAELFTQSCADL-DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE 1438

Query: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1171
            LQ     +S+  K  ++      + Q    E +    E+    L + ++
Sbjct: 1439 LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEI 1487



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 242/1280 (18%), Positives = 497/1280 (38%), Gaps = 158/1280 (12%)

Query: 259  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNV 318
            +K L ++SLL Q   + +    ++ D+L  V    V       G D  S +S ++ HK+V
Sbjct: 737  KKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV-------GHDEYSTQSLVKKHKDV 789

Query: 319  HRAIEEFESSLKEAKISEIQMTAPLKLTYAE------KLHRLESQYAKLLNTSRNQERHL 372
               I  +  +L        +  + L   +AE      +L  +E +Y ++   +R +++ L
Sbjct: 790  AEEIANYRPTLDTLH----EQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQAL 845

Query: 373  D---TLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENI 429
                 L+   S A    +W++EKE+        E+  ++   +     L  E++ +   +
Sbjct: 846  QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905

Query: 430  KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAK 489
              V +IA QL+   HP+   I+A +  + T+WS   +L    +  +    +   +  +  
Sbjct: 906  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965

Query: 490  EATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
            E   ++R     I+     D  + +  +  L ++    + +L+  ++ +++L  +A+ + 
Sbjct: 966  ETKSWIREKTKVIESTQ--DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE 1023

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW--------KVISP 601
               P  +   L     I  + +  +   T  K+ E  L   S   ++          +S 
Sbjct: 1024 SEHPDQAQAILSRLAEISDVWEEMK---TTLKNREASLGEASKLQQFLRDLDDFQSWLSR 1080

Query: 602  TGNEAMVPSVCFTVPPPNK---EAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLIN 658
            T        +  T+    K   +  ++ N I+   ++   +     +  +      Y+  
Sbjct: 1081 TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL 1140

Query: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 718
               R++A +    +     E++Q L +    ++ FL D+++++ F  +      +E  + 
Sbjct: 1141 R-QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNN------QEYVLA 1193

Query: 719  KQYYQELLKSAER--EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES 776
                   L+ AE   ++QE+ +  +  +E + I   +E    RL+      +  D + E 
Sbjct: 1194 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEK-INAVVETGR-RLVSDGN--INSDRIQEK 1249

Query: 777  VFRITEQEKLKKE-----LERLKD--DLGTITNKCEEFF------SQAAASSSVPTLRSE 823
            V  I ++ +  +E     L RLKD  DL      C+E           A   S    R+ 
Sbjct: 1250 VDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNL 1309

Query: 824  LNVVLQNMNQVYSMSST--YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 881
             +  L++   +  ++S   ++DK++   + L + +              E EAV+ +K  
Sbjct: 1310 HSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP-------------ETEAVVKEK-- 1354

Query: 882  IENLISTLKQWR---SEVDEKRQ-VFHALEDEL-QKAKAISDEMFKTYKERDLDFDWHKE 936
               L    K W    S    K Q +F A + EL  ++ A  D+     + +    D+ K+
Sbjct: 1355 ---LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKD 1411

Query: 937  --KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
                + L+++ Q +  Q++ R +++E +    +         D+   +  T Q K  E  
Sbjct: 1412 LTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFME-- 1469

Query: 995  PENSKTLATQLNQQKM-LVSEIEMKQSKMD---ECQKYAEQYS-ATVKDYELQTMTYRAM 1049
                  L   LN++K  L++  E+ Q   D   E     E+   AT  D+     T + +
Sbjct: 1470 ------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLL 1523

Query: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVT-----LMTQYIKFAGDSLKRLEE 1104
            +   Q    + +  Q   D I +   ++ T  ++L        +    +  G  ++  E+
Sbjct: 1524 IKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEK 1583

Query: 1105 EEKSLEEEKK--EHVEKAKELQKWVSNISKTLKDAEKAGKPP-----FSKQKISSEEIST 1157
              + LEE  +  ++   A E + W+S     +   EKA           K +I  + +  
Sbjct: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED 1643

Query: 1158 KKEQLSEALQTIQLFLA-KHGDK----MTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1212
              E + +  +T +  +A  H +     M   + ++L   +K L E       E  +  Q 
Sbjct: 1644 YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQL 1703

Query: 1213 SQTSGDVKVEEKLDKVIAGTIDQTTG-EVLSVFQAVLRGLIDYDTG---------IRLLE 1262
            ++   D++      +V+AG+ +     E +++ Q   R     DTG         +  L 
Sbjct: 1704 NREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFAR-DTGNIGQERVDTVNHLA 1762

Query: 1263 TQLMISGLISPELRKCFDLKDAKSHGLID--------EQILCQLKELSK----AKEIISA 1310
             +L+ SG    +     + KD  +    D         QIL    EL K    AKEI   
Sbjct: 1763 DELINSG--HSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1820

Query: 1311 ASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
                   + + L +   T    ++ L+ + +T    I A G Q+   +     L ++   
Sbjct: 1821 IQDKHKKLPEELGRDQNT----VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG 1876

Query: 1371 SK---VLERQNMC----KDLIDPCTSEKVSLIDMVQR---STLQENTGMWLLPVRPQEGG 1420
             K   + +R+N      K L+D C S +V L+D   +    ++  +  +W+  V  Q   
Sbjct: 1877 DKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1936

Query: 1421 RITLKCGRNISILRAAHEGL 1440
            +   +   ++ +L   H+G+
Sbjct: 1937 QEKPRDVSSVELLMNNHQGI 1956



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)

Query: 267 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
           +LD  +  E++  K+     DLL W+++  + L+  ++ + L  V+  L+   N +R +E
Sbjct: 293 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 351

Query: 324 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 383
           +     ++  +  +  T   K+    +   +  +   + + ++  ER     H       
Sbjct: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411

Query: 384 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 422
           NELI   + E+    +D        W   N  +  + ++             H  +  ++
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 471

Query: 423 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 482
              EE +++V  +A +L  EN+     I A +  +   W ++L+L +   Q ++ N    
Sbjct: 472 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 531

Query: 483 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 523
           + F +     D++  +K  +    S D    +  +EDL+Q+
Sbjct: 532 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 569



 Score = 40.8 bits (94), Expect = 0.021
 Identities = 67/336 (19%), Positives = 141/336 (41%), Gaps = 52/336 (15%)

Query: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF----DWHKEKADQL- 941
            +T+ +W+  ++E       L D   +  A S E+ K Y +    F    D HK+  ++L 
Sbjct: 1774 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1833

Query: 942  -----VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 996
                 VE  Q +H   ++   D++ +G  ++  ++    L     Q      K  + Q  
Sbjct: 1834 RDQNTVETLQRMHTTFEH---DIQALGTQVRQLQEDAARL-----QAAYAGDKADDIQKR 1885

Query: 997  NSKTLATQLNQQKMLVSEIEMKQSKM-DECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
             ++ L       K L+   E ++ ++ D   K+  ++ + V+D  L        +++Q+K
Sbjct: 1886 ENEVLEAW----KSLLDACESRRVRLVDTGDKF--RFFSMVRDLMLWMEDVIRQIEAQEK 1939

Query: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKR-------LEEEEKS 1108
                  R  SS +L++     ++    A     T  I+     L R       ++E+   
Sbjct: 1940 P-----RDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994

Query: 1109 LEEEKKEHVEKAKELQKW---VSNISKTLKDAEKA-----GKPPFSKQKISSEEISTKKE 1160
            L E++KE ++K ++  +W   +  + +  +DA  A     G+ P+    +SS EI    +
Sbjct: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPY----LSSREIGQSVD 2050

Query: 1161 QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
            ++ + ++  + F        T +ER    +++ TL+
Sbjct: 2051 EVEKLIKRHEAF---EKSAATWDERFSALERLTTLE 2083


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 206/1036 (19%), Positives = 409/1036 (39%), Gaps = 158/1036 (15%)

Query: 267  LLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 326
            L +Q+ T++   +  ++     ++ +++     E   ++ S+    +N K +  A+E   
Sbjct: 1311 LTEQSTTKDSTTLARIE-----MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365

Query: 327  SSLKE------AKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVS 380
              LKE      AKI E Q      L   EK    +++  K+++    +        + + 
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEK----DNETTKIVS----EMEQFKPKDSALL 1417

Query: 381  RATNELIWLNEKEEEEVAYDWSERNTNIARKKD----YHAELMRELDQKEENIKSVQEIA 436
            R   E++ L+++ +E       +   ++A++KD        L  E DQ +ENIK +  +A
Sbjct: 1418 RIEIEMLGLSKRLQES-----HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI--VA 1470

Query: 437  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 496
            + L  E       ++     ++ Q   I +L      ++ E            EA +   
Sbjct: 1471 KHLETEEE-----LKVAHCCLKEQEETINEL----RVNLSEKETEISTIQKQLEAIN--D 1519

Query: 497  NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKS-------TIANLMGKAKTII 549
             L++ IQ  Y  +   +I ++ + VQE + E ++  +++        +I + M +    +
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISE-VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578

Query: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLA---NNSHRAKWKVISPTGNEA 606
            Q         +K    +K + +  QIE    K++   +      S   +++ +  T    
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638

Query: 607  MVPSVCFTVPPPNKEAVDLAN--RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
                +C       +      N   IE +   +  + HE+   M+SV        E D +R
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTK------ERDDLR 1692

Query: 665  ASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE 724
                 S++  L  E  Q+  NL+      LE  +E ++                   +  
Sbjct: 1693 -----SVEETLKVERDQLKENLRETITRDLEKQEELKIV------------------HMH 1729

Query: 725  LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ---IRTPLERDDLH-----ES 776
            L +  E  ++   + +   +E+ N++  LE+  D L  Q   I+  L    +H     E+
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789

Query: 777  VFRITE--QEKLKKELERLKDDLGTITNKCEEFFSQAAASS-SVPTLRSELNVVLQNMNQ 833
            + ++     EK  K L  ++ DL     K +E   +  A+   + TL+ ++N   + +++
Sbjct: 1790 IDKLRGIVSEKTDK-LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848

Query: 834  VYSMSSTYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 892
            +  +     D+  T++ L ++N   A+   KL+E  L E ++V+ +++N+  +  TLK  
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQ---KLHEN-LEEMKSVMKERDNLRRVEETLKLE 1904

Query: 893  RSEVDEKRQVFHA----LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
            R ++ E  Q   A    ++ EL+ A+ +S E              HKE  D+L E+    
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKE--------------HKETVDKLREKISEK 1950

Query: 949  HVQIDNRLRDL----EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
             +QI +  +DL    + + K ++  +     L    + V  + +KI E +    +  A  
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010

Query: 1005 LNQQKM-------------LVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
            L+ Q +              + EI +   + DE ++  E      +D  + T+      D
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME-RDQFIATLREMIARD 2069

Query: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
             Q       +R+ S     + E   LR + + +  L+ +Y +   D  + L      LE+
Sbjct: 2070 RQNHQVKPEKRLLSDGQQHLTE--SLREKCSRIKELLKRYSEM-DDHYECLNRLSLDLEK 2126

Query: 1112 EKKEHVEKAKELQKWV-SNISKTLKDAEKAGKPPFSKQKISSE--EISTKKEQLSEALQT 1168
            E    +E  KEL   V +N+S      +   K   + Q+ S E   I  K + +   +  
Sbjct: 2127 E----IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK 2182

Query: 1169 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKV 1228
            I+    +  +K   +  +E+EKQ             E L ++Q  Q   DV   E  D  
Sbjct: 2183 IKEEQHESINKFEMDFIDEVEKQ------------KELLIKIQHLQQDCDVPSRELRDLK 2230

Query: 1229 IAGTIDQTTGEVLSVF 1244
            +   +D    E+L  F
Sbjct: 2231 LNQNMDLHIEEILKDF 2246



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 151/749 (20%), Positives = 301/749 (40%), Gaps = 137/749 (18%)

Query: 710  QLEKEVNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNI-----------RLRL 753
            Q+E ++    Q YQ  L++ ++     E++ +S +N  I+++ ++            L L
Sbjct: 664  QMENDI----QLYQSQLEAKKKMQVDLEKELQSAFN-EITKLTSLIDGKVPKDLLCNLEL 718

Query: 754  ENCEDRLIRQIRTPLERDD-LHESVFRITEQ-------EKLKKELERLKDDLGTITNKCE 805
            E     L +++   +E ++ L E V  ++E        E+L+KE++   ++L  IT++ +
Sbjct: 719  EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD 778

Query: 806  EFFSQAA-ASSSVPTLRSELNVV---LQNMNQVYSMSSTYIDKLKTVNL---------VL 852
            + FS+     S V  L  E+      L      Y  +       KT+++         + 
Sbjct: 779  KLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLE 838

Query: 853  KNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-- 910
            +N +  + +V L +     + ++ A K  +      L++   EV E+      L+++L  
Sbjct: 839  ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN 898

Query: 911  --------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD---- 958
                    ++ K +  E  +   E        K+   QL E  Q    Q+ + + D    
Sbjct: 899  RDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM 958

Query: 959  -------LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
                   L    +SLK +++T + L   I +  +    ++EN  E          QQKM+
Sbjct: 959  NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEF-----QQKMV 1013

Query: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
              +      K D   K  +  +A VKD E+     +     Q+K+      +Q   + +I
Sbjct: 1014 GID-----KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN-----ELQQMLESVI 1063

Query: 1072 QEFMDLRTRYTALVTLM---TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVS 1128
             E   L+T     + +     + ++  GD LK+   +++ + +EK   ++K  EL +   
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKK---QQEIVAQEKNHAIKKEGELSRTCD 1120

Query: 1129 NISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNEL 1188
             +++  +           K K  S+++  K++QL    + +     K  +   +  +NEL
Sbjct: 1121 RLAEVEE-----------KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE--IENLKNEL 1167

Query: 1189 EKQVKTLQ--ESYNLLFSESLKQLQESQTS--GDVKVEEKLDKVIAGTIDQTTGEVLSVF 1244
            + +  TL+  E+  L  ++ L +  E   S   + KV ++L K      D   G +  + 
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227

Query: 1245 QAVLRGLIDYDTG-IRLLETQLMISGL---ISPELRKCFDLKD-AKSHGLIDEQI----- 1294
               L+   +     I L E Q  I  L   +S +  +  + +D  KSH  + E+I     
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287

Query: 1295 ----LCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPAT 1350
                L  +KE+S+ +E ++     T        QS   +S  +  +E+            
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLT-------EQSTTKDSTTLARIEM------------ 1328

Query: 1351 GEQLTLQKAFQQNLVSSALFSKVLERQNM 1379
             E+L L + FQ++     + S   ER N+
Sbjct: 1329 -ERLRLNEKFQES--QEEIKSLTKERDNL 1354


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 240/1245 (19%), Positives = 482/1245 (38%), Gaps = 244/1245 (19%)

Query: 151  RNECSSVY--SKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTS-S 207
            +++C+ +Y  S  R+   E T +  S I ++L+SG   +     +  L   ++ +    S
Sbjct: 59   QSQCNEMYINSSQRV---ESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCS 115

Query: 208  SMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTLKLMQIRKPLLKSS 266
            S  +G S  M +            G P+ L+     GV+ + S Q  +       +++S 
Sbjct: 116  SEVNGCSFVMRT------------GKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESE 163

Query: 267  LLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFE 326
            L  +    EE+N +        ++EM+V    TE    L   E+ ++    +   I +  
Sbjct: 164  LAGKQHEIEELNRE--------LEEMRVTYG-TEGLQQLQEFEAAIKQRDGI---ITQLT 211

Query: 327  SSLKEAKISEIQ-MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
            ++L++A+  + + M   L+LT   +  +++ Q  +   T RN   H  T  + +      
Sbjct: 212  ANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNST-HSSTAADLLQAKQQI 270

Query: 386  LIWLNEKEEEE-VAYDWSERNTNIARKKDYHAELMR----ELDQKEENIKSVQEIAEQLL 440
            L    + EE++ +  D+ ++  +   +  +  E ++    E D+K EN    +   ++ +
Sbjct: 271  LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETI 330

Query: 441  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD 500
            +E    ++                          I+E     E  +    A   L  L++
Sbjct: 331  IEELNTKI--------------------------IEEEKKTLELKDKLTTADKLLGELQE 364

Query: 501  AIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRN-SDCP 559
             I +K          +++++  E    K++  Q    I  LMG   T+ +L+ RN  D  
Sbjct: 365  QIVQKNQ--------EIKNMKLELTNSKQKERQSSEEIKQLMG---TVEELQKRNHKDSQ 413

Query: 560  LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
             +T I        +++E    +  E + A          +     + +V      +    
Sbjct: 414  FETDI-------VQRMEQETQRKLEQLRAE---------LDEMYGQQIVQMKQELIRQHM 457

Query: 620  KEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 679
             +  ++  R + + +N L  +    +N   +   +  INE++ I+  +  S K  L  E 
Sbjct: 458  AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN-IKLQDTNSQKEKLKEEL 516

Query: 680  QQVLSN---LQSRFEDFLED----------SQESQVFSGSDITQLEKEVNVCKQYYQELL 726
              +L     LQ + ED +E+          ++++     S + +  K ++  +    E++
Sbjct: 517  GLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIV 576

Query: 727  KSAEREEQEESVYNLYISEVRNIRLRLENCE-------DRLIRQIRTPLERDDLHESVFR 779
             ++E  ++ E  +    +EV N +++LE  E       DR+       LER         
Sbjct: 577  SASESRKELELKHE---AEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSH 633

Query: 780  ITEQEKLKKELE--------RLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
              E  KLK++LE        +LKD+LG I  K +    Q   S  + T++ E + ++   
Sbjct: 634  EEELSKLKEDLEIEHRINIEKLKDNLG-IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692

Query: 832  NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK-----LCEEEAVIADKNNIENLI 886
            NQ+       I KLK +   L N+++ E  +++ E +     L +EE    +K  +E  +
Sbjct: 693  NQLI----LEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK---EKGTLEQEV 745

Query: 887  STL--------KQWRSEVDEKRQVFHALEDE---LQKAKAISDEMFKTY----------- 924
              L        KQ + + ++ ++ F  LE E   L+  K   ++M K +           
Sbjct: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805

Query: 925  ----KERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
                K +  D  W KE  + L+E  +++  Q      ++E    +  +    +      +
Sbjct: 806  LDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 981  QQ-----------VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1029
            Q+           +E ++ K +       K L  +L+ Q++  + ++MK S  DE + + 
Sbjct: 865  QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924

Query: 1030 ----EQYSATVKD----YELQTMTYRAMVD-SQQKSPVKRRRMQSSADLII--------- 1071
                E      KD     E   +T R  ++ SQ+ S +  +  Q   ++           
Sbjct: 925  AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984

Query: 1072 --QEFMDLRTRYTALVT---------------------LMTQYIKFAGDSLKRLE----E 1104
              +E + LR R   ++                      ++T   + A  S+ ++     E
Sbjct: 985  QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044

Query: 1105 EEKSLEEEKKEHV-----EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
            E K + E+K         E++K+ Q  + ++    K++      P    K+  E    K 
Sbjct: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104

Query: 1160 EQLSEALQT------IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQ-- 1211
            EQ    LQ       + L  + H D++ +   NE +K + +L+E       E +K+LQ  
Sbjct: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164

Query: 1212 --------ESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVL 1248
                    ++Q +GD   E K   ++ G + +   E  S F   L
Sbjct: 1165 HQLELQTMKTQETGD---EGKPLHLLIGKLQKAVSEECSYFLQTL 1206



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 117/599 (19%), Positives = 253/599 (42%), Gaps = 85/599 (14%)

Query: 673  TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE 732
            T +  E+++++ N+ SR +  +E   E+       I++   ++   K    EL++ + R+
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEA-------ISETSSQLEHAKVTQTELMRESFRQ 1885

Query: 733  EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDL-------HESVFRITEQEK 785
            +QE +  +L   E   +R RL   E R   Q+   L + +         +++F    QEK
Sbjct: 1886 KQE-ATESLKCQE--ELRERLHE-ESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEK 1941

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAA--------SSSVPTLRSELNVVLQNMNQVYSM 837
                ++RL+ +L   +N+ +E  ++           S     +++E   V Q + Q    
Sbjct: 1942 TDI-IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ--ET 1998

Query: 838  SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                 +KL+      K     +  VK  E  + E+         +   I   ++  +E+ 
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQ---------VSRFIELEQEKNTELM 2049

Query: 898  EKRQVFHALEDELQKAKAISDEM-FKTYKERDLDFDWHKEKADQ---LVERWQNVHVQID 953
            + RQ   ALE +L+K +   DE       ERD+ F    +K +Q   +V R+Q +    +
Sbjct: 2050 DLRQQNQALEKQLEKMRKFLDEQAIDREHERDV-FQQEIQKLEQQLKVVPRFQPIS---E 2105

Query: 954  NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKT-LATQLNQQKMLV 1012
            ++ R++E +   LK   D    L   +   E  QR IQE   E  K     +  +Q +LV
Sbjct: 2106 HQTREVEQLANHLKEKTDKCSEL---LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162

Query: 1013 SE-------------------------IEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047
             +                         I+ K+ ++   ++  EQ+   +++   +     
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222

Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMD---LRTRYTALVTLMTQYIKFAGDSLKRLEE 1104
              ++ Q+K    R +     + + ++ M+   L  + +  ++   Q++ F G   + ++E
Sbjct: 2223 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF-GKFAQIIQE 2281

Query: 1105 EEKSLEEEKKEHVEKAKELQ-----KWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
            +E  +++  ++  +  ++L+     K +   ++ ++D E   +   S Q+        + 
Sbjct: 2282 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEI 2341

Query: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1218
            EQL+E ++ +Q  LA  G K T    + L ++  +L+   +++ +E L   Q+ +T+ +
Sbjct: 2342 EQLNEVIEKLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2399



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 178/1016 (17%), Positives = 390/1016 (38%), Gaps = 194/1016 (19%)

Query: 324  EFESSLKEAKISEIQMTAPLKLTYAEKLH-RLES--QYAKLL--NTSRNQERHLDTLHNF 378
            +FE+ + + KI  +Q     K+  A     +LE+  +YAK    N + + E     + N 
Sbjct: 2522 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN- 2580

Query: 379  VSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
                      LN+  E+E+  D S     I+  +    E+   L  ++E +    EIAE+
Sbjct: 2581 ----------LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQV----EIAEK 2626

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNL 498
             +LE                     +L+L + +E + K+         + K +   +  L
Sbjct: 2627 NVLEKEKK-----------------LLELQKLLEGNEKKQRE-----KEKKRSPQDVEVL 2664

Query: 499  KDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTI-----------ANLMGKAKT 547
            K   +  +S + S   ++LE L  ES+  K EL  YK               N+    K 
Sbjct: 2665 KTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2724

Query: 548  IIQLKPRNSDCPLKTSI----------PIKAICDYRQIEITIYKD-----DECVLANNSH 592
            + Q++   ++   K SI            K  C +  + I + K      D  +  ++S+
Sbjct: 2725 LSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSN 2784

Query: 593  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 652
            +    ++   G +  + S C      ++E  ++ ++  ++ + +  L     ++M+S   
Sbjct: 2785 QTPQILVKNAGIQINLQSEC-----SSEEVTEIISQFTEKIEKMQELHAAEILDMES--- 2836

Query: 653  WHYLINEIDRIRASNVASIKTMLP--GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
                I+E + ++  +  +++ +    G  + V+  L+S+    + +   S  +   +I  
Sbjct: 2837 --RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICS 2894

Query: 711  LEKEVNVCKQYYQEL-----LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR 765
             +   +  +  Y        + S  R E+ ES  + +  +++ +   + N   +++    
Sbjct: 2895 SDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTE 2954

Query: 766  TPLERDDLHE----SVFRITEQEKLKKELERLKDDLGTITNKCE-EFFSQAAASSSVPTL 820
            +P    + H     S   + E++     +  LKD +  +  + E E +  + +  S    
Sbjct: 2955 SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3014

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEE----EAVI 876
            R EL + LQ   QV+    + +       L    T  A  L+   E ++ E+    +A +
Sbjct: 3015 RGELLLALQ---QVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAM 3071

Query: 877  A--DKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYK----ERDLD 930
                K +  +L+S ++   ++++ ++      ++  + ++ + +   +  +    E  ++
Sbjct: 3072 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3131

Query: 931  FDWHKEKADQLVERWQNVHVQI---------------------DNRLRDLEGIGKSLKYY 969
                K++A +L E+  +  + +                        L++LE     +K  
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191

Query: 970  RDTYHPLDDWIQQVETTQRKIQ----------------------------ENQPENSKTL 1001
             D  H L+D +   +   R++Q                            E+Q + +  L
Sbjct: 3192 TDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL 3251

Query: 1002 ATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
               L QQK L++E + K   Q  + + Q   EQ     ++ ELQ +     V  ++ S  
Sbjct: 3252 NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQG----RNLELQVLLESEKVRIREMSST 3307

Query: 1059 KRR------RMQSS------------ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLK 1100
              R      ++QSS             DL+ +    L  +++ +V L+ +  K+  DSL+
Sbjct: 3308 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3367

Query: 1101 RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKE 1160
              ++ EK  +  +K                 +T ++A   G+    + +   E++  + E
Sbjct: 3368 TRQQMEKDRQVHRK---------------TLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3412

Query: 1161 QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1216
            +  + +  + L   +    M + ++ ELE++ K  +ES  +L+    +    S TS
Sbjct: 3413 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK--RESRRILYQNLNEPTTWSLTS 3466



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 73/318 (22%), Positives = 129/318 (40%), Gaps = 55/318 (17%)

Query: 2294 VAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVT 2353
            + E+ D++     LNE  ++  N           + S  EK   VN  +L       L+ 
Sbjct: 826  IEENEDLKQQCIQLNEEIEKQRN-----------TFSFAEKNFEVNYQELQEEYAC-LLK 873

Query: 2354 EKSNLPEYTT--EIAGKSKENLLNHEMVLKDVLPPIIKDTES----EKTFGPASISHDNN 2407
             K +L +     E+  KSK   LN E+ L+ + P  +K   S    +KTF   ++     
Sbjct: 874  VKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933

Query: 2408 NISSTSELGTDLANTKVKLIQGSE-LPELTDSVKGKDEYFKNMTPKVDSSLDH-----II 2461
                T+EL   L  TK + ++ S+ L +L++ +K K      +  +V S         + 
Sbjct: 934  VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993

Query: 2462 CTEPDLI--GKPAEE---------SHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDE 2510
            C E ++I     AE          S L  + ++T +  +G+ S + K    +S I++ED+
Sbjct: 994  CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053

Query: 2511 TSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKG 2570
             S + M +GE         ++E   L  LP      S +               + ++  
Sbjct: 1054 VSFENMTVGEES-------KQEQLILDHLPSVTKESSLRA-------------TQPSEND 1093

Query: 2571 SLKKATVTLKDEPNNLQI 2588
             L+K    LK E N+L++
Sbjct: 1094 KLQKELNVLKSEQNDLRL 1111


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 112,299,486
Number of Sequences: 37866
Number of extensions: 5266476
Number of successful extensions: 26890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 807
Number of HSP's that attempted gapping in prelim test: 18930
Number of HSP's gapped (non-prelim): 5415
length of query: 3062
length of database: 18,247,518
effective HSP length: 121
effective length of query: 2941
effective length of database: 13,665,732
effective search space: 40190917812
effective search space used: 40190917812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.