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Search of human proteins with 20127528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20127528 parvin, beta isoform b [Homo sapiens]
(364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20127528 parvin, beta isoform b [Homo sapiens] 719 0.0
gi|51477696 parvin, beta isoform a [Homo sapiens] 646 0.0
gi|8922673 parvin, alpha [Homo sapiens] 543 e-154
gi|212286181 parvin, gamma [Homo sapiens] 261 5e-70
gi|212286179 parvin, gamma [Homo sapiens] 261 5e-70
gi|11545879 parvin, gamma [Homo sapiens] 261 5e-70
gi|12025678 actinin, alpha 4 [Homo sapiens] 48 2e-05
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 47 4e-05
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 47 4e-05
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 47 4e-05
gi|4557241 actinin, alpha 3 [Homo sapiens] 46 5e-05
gi|4501893 actinin, alpha 2 [Homo sapiens] 44 2e-04
gi|83816971 DIX domain containing 1 isoform a [Homo sapiens] 43 4e-04
gi|221316624 dystonin isoform 4 [Homo sapiens] 43 5e-04
gi|221316622 dystonin isoform 3 [Homo sapiens] 43 5e-04
gi|221316618 dystonin isoform 2 [Homo sapiens] 43 5e-04
gi|33188445 microfilament and actin filament cross-linker protei... 42 7e-04
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 42 7e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 42 0.001
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 41 0.002
gi|188595687 gamma filamin isoform b [Homo sapiens] 40 0.003
gi|116805322 gamma filamin isoform a [Homo sapiens] 40 0.003
gi|105990514 filamin B, beta (actin binding protein 278) [Homo s... 40 0.004
gi|34577047 dystonin isoform 1 [Homo sapiens] 39 0.006
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 39 0.006
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 39 0.006
gi|160420317 filamin A, alpha isoform 2 [Homo sapiens] 39 0.007
gi|116063573 filamin A, alpha isoform 1 [Homo sapiens] 39 0.007
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 39 0.007
gi|67782321 spectrin beta isoform a [Homo sapiens] 39 0.010
>gi|20127528 parvin, beta isoform b [Homo sapiens]
Length = 364
Score = 719 bits (1855), Expect = 0.0
Identities = 364/364 (100%), Positives = 364/364 (100%)
Query: 1 MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDV 60
MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDV
Sbjct: 1 MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDV 60
Query: 61 HPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQV 120
HPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQV
Sbjct: 61 HPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQV 120
Query: 121 LQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLV 180
LQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLV
Sbjct: 121 LQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLV 180
Query: 181 AILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERD 240
AILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERD
Sbjct: 181 AILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERD 240
Query: 241 AFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFV 300
AFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFV
Sbjct: 241 AFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFV 300
Query: 301 PLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY 360
PLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY
Sbjct: 301 PLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY 360
Query: 361 KNVE 364
KNVE
Sbjct: 361 KNVE 364
>gi|51477696 parvin, beta isoform a [Homo sapiens]
Length = 397
Score = 646 bits (1667), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 38 VSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWI 97
VSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWI
Sbjct: 71 VSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWI 130
Query: 98 NDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVH 157
NDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVH
Sbjct: 131 NDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVH 190
Query: 158 DLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL 217
DLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL
Sbjct: 191 DLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL 250
Query: 218 HSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTE 277
HSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTE
Sbjct: 251 HSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTE 310
Query: 278 LETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKAR 337
LETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKAR
Sbjct: 311 LETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKAR 370
Query: 338 PEDVVNLDLKSTLRVLYNLFTKYKNVE 364
PEDVVNLDLKSTLRVLYNLFTKYKNVE
Sbjct: 371 PEDVVNLDLKSTLRVLYNLFTKYKNVE 397
>gi|8922673 parvin, alpha [Homo sapiens]
Length = 372
Score = 543 bits (1398), Expect = e-154
Identities = 272/363 (74%), Positives = 316/363 (87%), Gaps = 1/363 (0%)
Query: 3 SAPRSPTPR-PRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVH 61
S P+SPTP+ P KKD+SFLGKLGGTLAR+++A+EVS+LQEEG NAIN P+SP ++
Sbjct: 10 SVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELD 69
Query: 62 PEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVL 121
PEDT LEENE RTM+DP S+ DPK +EL+KVL+DWINDVLV ERIIVK L EDLYDGQVL
Sbjct: 70 PEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVL 129
Query: 122 QKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVA 181
QKL EKL KLNVAEVTQSEI QKQKLQTVLE +++ L+ +++W+VDS+H K+LVA
Sbjct: 130 QKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVA 189
Query: 182 ILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDA 241
ILHLLV+L+ +FRAPIRLP+HV++QVVVV+KREG+L S I EE+T TE + GR ERDA
Sbjct: 190 ILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDA 249
Query: 242 FDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVP 301
FDTLFDHAPDKL+VVKK+LITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLE YFVP
Sbjct: 250 FDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVP 309
Query: 302 LHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
LH F+LTP+SF+QKV NVSFAFELM DGGL+KPK RPED+VN DLKSTLRVLYNLFTKY+
Sbjct: 310 LHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYR 369
Query: 362 NVE 364
NVE
Sbjct: 370 NVE 372
>gi|212286181 parvin, gamma [Homo sapiens]
Length = 331
Score = 261 bits (668), Expect = 5e-70
Identities = 136/301 (45%), Positives = 198/301 (65%), Gaps = 5/301 (1%)
Query: 62 PEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVL 121
P + +L + ++ + PTS++DPKF+EL KVL++WIN L+ E I+V+ LEED++DG +L
Sbjct: 19 PAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLPEHIVVRSLEEDMFDGLIL 78
Query: 122 QKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVA 181
L ++LA KL ++ + QK KL VLEAV+ L+ W +WSV+SI K+L++
Sbjct: 79 HHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLS 138
Query: 182 ILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFE--R 239
LHLLV+LA F+ + LP +V V+V+ + + L S + E+L TE + E +
Sbjct: 139 TLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLVEQL---TEYSTDKDEPPK 195
Query: 240 DAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYF 299
D FD LF AP+K++ VK++++ FVN+ L++L L V L+TQFADGV L+LL+G LE +F
Sbjct: 196 DVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFF 255
Query: 300 VPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
+ L FYLTP S + +HNV+ A EL+ D GL PED+VN D KSTLRVLY LF K
Sbjct: 256 LHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCK 315
Query: 360 Y 360
+
Sbjct: 316 H 316
>gi|212286179 parvin, gamma [Homo sapiens]
Length = 331
Score = 261 bits (668), Expect = 5e-70
Identities = 136/301 (45%), Positives = 198/301 (65%), Gaps = 5/301 (1%)
Query: 62 PEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVL 121
P + +L + ++ + PTS++DPKF+EL KVL++WIN L+ E I+V+ LEED++DG +L
Sbjct: 19 PAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLPEHIVVRSLEEDMFDGLIL 78
Query: 122 QKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVA 181
L ++LA KL ++ + QK KL VLEAV+ L+ W +WSV+SI K+L++
Sbjct: 79 HHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLS 138
Query: 182 ILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFE--R 239
LHLLV+LA F+ + LP +V V+V+ + + L S + E+L TE + E +
Sbjct: 139 TLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLVEQL---TEYSTDKDEPPK 195
Query: 240 DAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYF 299
D FD LF AP+K++ VK++++ FVN+ L++L L V L+TQFADGV L+LL+G LE +F
Sbjct: 196 DVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFF 255
Query: 300 VPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
+ L FYLTP S + +HNV+ A EL+ D GL PED+VN D KSTLRVLY LF K
Sbjct: 256 LHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCK 315
Query: 360 Y 360
+
Sbjct: 316 H 316
>gi|11545879 parvin, gamma [Homo sapiens]
Length = 331
Score = 261 bits (668), Expect = 5e-70
Identities = 136/301 (45%), Positives = 198/301 (65%), Gaps = 5/301 (1%)
Query: 62 PEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVL 121
P + +L + ++ + PTS++DPKF+EL KVL++WIN L+ E I+V+ LEED++DG +L
Sbjct: 19 PAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLPEHIVVRSLEEDMFDGLIL 78
Query: 122 QKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVA 181
L ++LA KL ++ + QK KL VLEAV+ L+ W +WSV+SI K+L++
Sbjct: 79 HHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLS 138
Query: 182 ILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFE--R 239
LHLLV+LA F+ + LP +V V+V+ + + L S + E+L TE + E +
Sbjct: 139 TLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLVEQL---TEYSTDKDEPPK 195
Query: 240 DAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYF 299
D FD LF AP+K++ VK++++ FVN+ L++L L V L+TQFADGV L+LL+G LE +F
Sbjct: 196 DVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFF 255
Query: 300 VPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
+ L FYLTP S + +HNV+ A EL+ D GL PED+VN D KSTLRVLY LF K
Sbjct: 256 LHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCK 315
Query: 360 Y 360
+
Sbjct: 316 H 316
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 47.8 bits (112), Expect = 2e-05
Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ ++ F DG+ L+LL+ ++ +P
Sbjct: 41 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLP- 97
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
PE +VH NV+ A + + G+K E++V+ + K TL +++ + +
Sbjct: 98 -----KPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILR 152
Query: 360 Y 360
+
Sbjct: 153 F 153
Score = 28.9 bits (63), Expect = 7.6
Identities = 19/75 (25%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 83 DPKF-KELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQS 141
DP + K+ K W N L + ++ ++ED DG L LLE ++G +L E +
Sbjct: 45 DPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKM 104
Query: 142 EIGQKQKLQTVLEAV 156
+ + + L+ +
Sbjct: 105 RVHKINNVNKALDFI 119
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ +E F DG+ L+LL+ ++
Sbjct: 22 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISG----- 74
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
PE +VH NV+ A + + G+K E++V+ ++K TL +++ + +
Sbjct: 75 -ERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILR 133
Query: 360 Y 360
+
Sbjct: 134 F 134
Score = 30.8 bits (68), Expect = 2.0
Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 6/92 (6%)
Query: 66 QLEENEERTMI-DPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKL 124
Q EE+ +R ++ DP ++ + K W N L + ++ +EED DG L L
Sbjct: 14 QPEEDWDRDLLLDPAWEKQQR-----KTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL 68
Query: 125 LEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAV 156
LE ++G +L E + + + + L+ +
Sbjct: 69 LEVISGERLAKPERGKMRVHKISNVNKALDFI 100
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ +E F DG+ L+LL+ ++
Sbjct: 22 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISG----- 74
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
PE +VH NV+ A + + G+K E++V+ ++K TL +++ + +
Sbjct: 75 -ERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILR 133
Query: 360 Y 360
+
Sbjct: 134 F 134
Score = 30.8 bits (68), Expect = 2.0
Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 6/92 (6%)
Query: 66 QLEENEERTMI-DPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKL 124
Q EE+ +R ++ DP ++ + K W N L + ++ +EED DG L L
Sbjct: 14 QPEEDWDRDLLLDPAWEKQQR-----KTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL 68
Query: 125 LEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAV 156
LE ++G +L E + + + + L+ +
Sbjct: 69 LEVISGERLAKPERGKMRVHKISNVNKALDFI 100
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ +E F DG+ L+LL+ ++
Sbjct: 22 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISG----- 74
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
PE +VH NV+ A + + G+K E++V+ ++K TL +++ + +
Sbjct: 75 -ERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILR 133
Query: 360 Y 360
+
Sbjct: 134 F 134
Score = 30.8 bits (68), Expect = 2.0
Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 6/92 (6%)
Query: 66 QLEENEERTMI-DPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKL 124
Q EE+ +R ++ DP ++ + K W N L + ++ +EED DG L L
Sbjct: 14 QPEEDWDRDLLLDPAWEKQQR-----KTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL 68
Query: 125 LEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAV 156
LE ++G +L E + + + + L+ +
Sbjct: 69 LEVISGERLAKPERGKMRVHKISNVNKALDFI 100
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 46.2 bits (108), Expect = 5e-05
Identities = 30/121 (24%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ +E F +G+ L+LL+ ++ +P
Sbjct: 36 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLP- 92
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
P+ + H NV+ A + + G+K E++V+ +LK TL +++ + +
Sbjct: 93 -----RPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILR 147
Query: 360 Y 360
+
Sbjct: 148 F 148
Score = 28.5 bits (62), Expect = 9.9
Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 5/68 (7%)
Query: 66 QLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLL 125
Q E+ + ++DP ++ + K W N L + ++ +EED +G L LL
Sbjct: 29 QEEDWDRDLLLDPAWEKQQR-----KTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 83
Query: 126 EKLAGCKL 133
E ++G +L
Sbjct: 84 EVISGERL 91
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/121 (23%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L D A +K +K+ + N HL K ++ +E F +G+ L+LL+ ++ +P
Sbjct: 29 DLLLDPAWEKQQ--RKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLP- 85
Query: 303 HHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTK 359
P+ + H NV+ A + + G+K E++V+ ++K TL +++ + +
Sbjct: 86 -----KPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILR 140
Query: 360 Y 360
+
Sbjct: 141 F 141
Score = 30.0 bits (66), Expect = 3.4
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 8/77 (10%)
Query: 60 VHPEDTQLEENEE---RTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLY 116
V+ ED + + EE ++DP ++ + K W N L + ++ +EED
Sbjct: 13 VYDEDEYMIQEEEWDRDLLLDPAWEKQQR-----KTFTAWCNSHLRKAGTQIENIEEDFR 67
Query: 117 DGQVLQKLLEKLAGCKL 133
+G L LLE ++G +L
Sbjct: 68 NGLKLMLLLEVISGERL 84
>gi|83816971 DIX domain containing 1 isoform a [Homo sapiens]
Length = 683
Score = 43.1 bits (100), Expect = 4e-04
Identities = 30/111 (27%), Positives = 62/111 (55%), Gaps = 6/111 (5%)
Query: 87 KELVKVLLDWINDVLVEERII--VKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIG 144
++ ++ + W+N L + + V+ L +DL DG +L L+E +AG KL+ +++ G
Sbjct: 20 EQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSP---G 76
Query: 145 QKQKLQTVLEAVHDLLRPRGWAL-RWSVDSIHGKNLVAILHLLVSLAMHFR 194
+Q+++ +E V + + + + S I NL +I+ L+++LA HF+
Sbjct: 77 NQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
Score = 30.8 bits (68), Expect = 2.0
Identities = 24/106 (22%), Positives = 49/106 (46%), Gaps = 4/106 (3%)
Query: 258 KSLITFVNKHLNKLNL--EVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQK 315
++ + +VN L K V +L DGV L L+ ++ L L+P + +
Sbjct: 24 QAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGE--KLSGVQLSPGNQQEM 81
Query: 316 VHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
+NV + + ++ + +D+V+ +LKS +R++ L +K
Sbjct: 82 KNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/176 (28%), Positives = 76/176 (43%), Gaps = 21/176 (11%)
Query: 54 SPALVDVHPEDTQLEENEER-----TMIDPTSKE-----DPKFKELVKVLLDWINDVLVE 103
SPA D P + E +R +++DP + D + K K WIN L++
Sbjct: 21 SPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMK 80
Query: 104 ERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLR 161
R V L EDL DG L LLE L+G + E G+ + +LQ V A+ L R
Sbjct: 81 VRKHVNDLYEDLRDGHNLISLLEVLSG------DTLPREKGRMRFHRLQNVQIALDYLKR 134
Query: 162 PRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL 217
+ + D I N L L+ ++ +HF+ HVT + + +E LL
Sbjct: 135 RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS---DIHVTGESEDMSAKERLL 187
Score = 37.0 bits (84), Expect = 0.028
Identities = 25/113 (22%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 249 APDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLT 308
A ++ V KK+ ++N+HL K+ V +L DG L+ L+ +L +P +
Sbjct: 59 ADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 118
Query: 309 PESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
++ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 119 ----FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 167
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/176 (28%), Positives = 76/176 (43%), Gaps = 21/176 (11%)
Query: 54 SPALVDVHPEDTQLEENEER-----TMIDPTSKE-----DPKFKELVKVLLDWINDVLVE 103
SPA D P + E +R +++DP + D + K K WIN L++
Sbjct: 32 SPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMK 91
Query: 104 ERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLR 161
R V L EDL DG L LLE L+G + E G+ + +LQ V A+ L R
Sbjct: 92 VRKHVNDLYEDLRDGHNLISLLEVLSG------DTLPREKGRMRFHRLQNVQIALDYLKR 145
Query: 162 PRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL 217
+ + D I N L L+ ++ +HF+ HVT + + +E LL
Sbjct: 146 RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS---DIHVTGESEDMSAKERLL 198
Score = 37.0 bits (84), Expect = 0.028
Identities = 25/113 (22%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 249 APDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLT 308
A ++ V KK+ ++N+HL K+ V +L DG L+ L+ +L +P +
Sbjct: 70 ADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 129
Query: 309 PESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
++ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 130 ----FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 178
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/176 (28%), Positives = 76/176 (43%), Gaps = 21/176 (11%)
Query: 54 SPALVDVHPEDTQLEENEER-----TMIDPTSKE-----DPKFKELVKVLLDWINDVLVE 103
SPA D P + E +R +++DP + D + K K WIN L++
Sbjct: 170 SPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMK 229
Query: 104 ERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLR 161
R V L EDL DG L LLE L+G + E G+ + +LQ V A+ L R
Sbjct: 230 VRKHVNDLYEDLRDGHNLISLLEVLSG------DTLPREKGRMRFHRLQNVQIALDYLKR 283
Query: 162 PRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLL 217
+ + D I N L L+ ++ +HF+ HVT + + +E LL
Sbjct: 284 RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS---DIHVTGESEDMSAKERLL 336
Score = 37.0 bits (84), Expect = 0.028
Identities = 25/113 (22%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 249 APDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLT 308
A ++ V KK+ ++N+HL K+ V +L DG L+ L+ +L +P +
Sbjct: 208 ADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 267
Query: 309 PESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
++ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 268 ----FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 316
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 42.4 bits (98), Expect = 7e-04
Identities = 47/174 (27%), Positives = 77/174 (44%), Gaps = 20/174 (11%)
Query: 32 KRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEER----TMIDPTSKE----- 82
+R R + E ++ SP P D P + L E ++R +++DP +
Sbjct: 17 ERSCRSERSYRSERSGSL-SPCPPG--DTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVA 73
Query: 83 DPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSE 142
D + + K W+N L++ R + L EDL DG L LLE L+G KL E
Sbjct: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKL------PRE 127
Query: 143 IGQKQ--KLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFR 194
G+ + +LQ V A+ L + + + D I N L L+ ++ +HF+
Sbjct: 128 KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 181
Score = 39.7 bits (91), Expect = 0.004
Identities = 26/113 (23%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 249 APDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLT 308
A ++ V KK+ +VNKHL K+ + +L DG L+ L+ +L +P +
Sbjct: 73 ADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMR 132
Query: 309 PESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
++ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 133 ----FHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 181
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 42.4 bits (98), Expect = 7e-04
Identities = 30/128 (23%), Positives = 61/128 (47%), Gaps = 12/128 (9%)
Query: 237 FERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLE 296
FER L D ++ +V KK+ +VN HL +++ +T+L T DG L+ L+ +L
Sbjct: 40 FERSRIKALAD---EREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLS 96
Query: 297 DYFVPLHHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVL 353
+P P ++H NV A + + + + D+V+ + + TL ++
Sbjct: 97 GERLP------KPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLI 150
Query: 354 YNLFTKYK 361
+ + +++
Sbjct: 151 WTIILRFQ 158
Score = 32.3 bits (72), Expect = 0.68
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 91 KVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKL 133
K W+N L + L DL DG++L KLLE L+G +L
Sbjct: 58 KTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 100
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/144 (27%), Positives = 63/144 (43%), Gaps = 12/144 (8%)
Query: 57 LVDVHPEDTQLEENEERTMI----DPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLE 112
L +V PE + +RT+ +P D + + K W+N L++ + + L
Sbjct: 145 LEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLY 204
Query: 113 EDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLRPRGWALRWS 170
EDL DG L LLE L+G L E G+ + KLQ V A+ L + +
Sbjct: 205 EDLRDGHNLISLLEVLSGDSL------PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIR 258
Query: 171 VDSIHGKNLVAILHLLVSLAMHFR 194
D I N L L+ ++ +HF+
Sbjct: 259 NDDIADGNPKLTLGLIWTIILHFQ 282
Score = 38.1 bits (87), Expect = 0.012
Identities = 26/107 (24%), Positives = 50/107 (46%), Gaps = 4/107 (3%)
Query: 255 VVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQ 314
V KK+ +VNKHL K +++L DG L+ L+ +L +P +
Sbjct: 180 VQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR----FH 235
Query: 315 KVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
K+ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 236 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 282
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 40.8 bits (94), Expect = 0.002
Identities = 40/144 (27%), Positives = 63/144 (43%), Gaps = 12/144 (8%)
Query: 57 LVDVHPEDTQLEENEERTMI----DPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLE 112
L +V PE + +RT+ +P D + + K W+N L++ + + L
Sbjct: 141 LEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTSTKWVNKHLIKAQRHISDLY 200
Query: 113 EDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLRPRGWALRWS 170
EDL DG L LLE L+G L E G+ + KLQ V A+ L + +
Sbjct: 201 EDLRDGHNLISLLEVLSGDSL------PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIR 254
Query: 171 VDSIHGKNLVAILHLLVSLAMHFR 194
D I N L L+ ++ +HF+
Sbjct: 255 NDDIADGNPKLTLGLIWTIILHFQ 278
Score = 37.4 bits (85), Expect = 0.021
Identities = 26/107 (24%), Positives = 50/107 (46%), Gaps = 4/107 (3%)
Query: 255 VVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQ 314
V KK+ +VNKHL K +++L DG L+ L+ +L +P +
Sbjct: 176 VQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR----FH 231
Query: 315 KVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
K+ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 232 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 278
>gi|188595687 gamma filamin isoform b [Homo sapiens]
Length = 2692
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/116 (25%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 245 LFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHH 304
L + AP K + + + + N+HL + +T+L+ +DG+ L+ L+ +L +
Sbjct: 28 LAEDAPWK-KIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRM-YRK 85
Query: 305 FYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY 360
F+ P K+ NVS A E + +K + +V+ +LK L +++ L Y
Sbjct: 86 FHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHY 141
>gi|116805322 gamma filamin isoform a [Homo sapiens]
Length = 2725
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/116 (25%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 245 LFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHH 304
L + AP K + + + + N+HL + +T+L+ +DG+ L+ L+ +L +
Sbjct: 28 LAEDAPWK-KIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRM-YRK 85
Query: 305 FYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY 360
F+ P K+ NVS A E + +K + +V+ +LK L +++ L Y
Sbjct: 86 FHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHY 141
>gi|105990514 filamin B, beta (actin binding protein 278) [Homo
sapiens]
Length = 2602
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/116 (24%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 245 LFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHH 304
L + AP K + + + + N+HL +N + L+T +DG+ L+ L+ +L +
Sbjct: 8 LAEDAPWK-KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRM-YRK 65
Query: 305 FYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY 360
++ P ++ NVS A E + +K + +V+ +LK L +++ L Y
Sbjct: 66 YHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHY 121
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 39.3 bits (90), Expect = 0.006
Identities = 42/138 (30%), Positives = 62/138 (44%), Gaps = 11/138 (7%)
Query: 82 EDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQS 141
+D + K K WIN L++ R V L EDL DG L LLE L+G +
Sbjct: 30 KDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG------DTLPR 83
Query: 142 EIGQKQ--KLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRL 199
E G+ + +LQ V A+ L R + + D I N L L+ ++ +HF+
Sbjct: 84 EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--- 140
Query: 200 PEHVTVQVVVVRKREGLL 217
HVT + + +E LL
Sbjct: 141 DIHVTGESEDMSAKERLL 158
Score = 37.7 bits (86), Expect = 0.016
Identities = 26/119 (21%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 243 DTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPL 302
D L + ++ V KK+ ++N+HL K+ V +L DG L+ L+ +L +P
Sbjct: 24 DVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR 83
Query: 303 HHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
+ ++ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 84 EKGRMR----FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 39.3 bits (90), Expect = 0.006
Identities = 25/114 (21%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 251 DKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPE 310
++ +V KK+ +VN HL +++ +T+L T DG L+ L+ +L +P P
Sbjct: 38 EREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLP------KPT 91
Query: 311 SFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
++H NV A + + + + D+V+ + + TL +++ + +++
Sbjct: 92 KGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQ 145
Score = 36.2 bits (82), Expect = 0.047
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 47 NAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERI 106
++I+ P+SPA P + E + + D +E + K K W+N L
Sbjct: 7 SSISGPLSPAYTGQVPYNYNQLEGRFKQLQD--EREAVQKKTFTK----WVNSHLARVSC 60
Query: 107 IVKQLEEDLYDGQVLQKLLEKLAGCKL 133
+ L DL DG++L KLLE L+G +L
Sbjct: 61 RITDLYTDLRDGRMLIKLLEVLSGERL 87
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 39.3 bits (90), Expect = 0.006
Identities = 27/115 (23%), Positives = 53/115 (46%), Gaps = 4/115 (3%)
Query: 247 DHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFY 306
D ++ V KK+ +VNKHL K +++L DG L+ L+ +L +P
Sbjct: 35 DEQDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 307 LTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
+ K+ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 95 MR----FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 145
Score = 36.2 bits (82), Expect = 0.047
Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 8/116 (6%)
Query: 81 KEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQ 140
++D + + K W+N L++ + + L EDL DG L LLE L+G L
Sbjct: 36 EQDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL------P 89
Query: 141 SEIGQKQ--KLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFR 194
E G+ + KLQ V A+ L + + D I N L L+ ++ +HF+
Sbjct: 90 REKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 145
>gi|160420317 filamin A, alpha isoform 2 [Homo sapiens]
Length = 2647
Score = 38.9 bits (89), Expect = 0.007
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 8/133 (6%)
Query: 229 TTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYL 288
T + M E+D L + AP K + + + + N+HL ++ + L+T +DG+ L
Sbjct: 23 TRDAEMPATEKD----LAEDAPWK-KIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRL 77
Query: 289 VLLMGLLEDYFVPLHHFYLTPESFDQ-KVHNVSFAFELMLDGGLKKPKARPEDVVNLDLK 347
+ L+ +L +H + +F Q ++ NVS A E + +K + +V+ +LK
Sbjct: 78 IALLEVLSQ--KKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLK 135
Query: 348 STLRVLYNLFTKY 360
L +++ L Y
Sbjct: 136 LILGLIWTLILHY 148
Score = 28.9 bits (63), Expect = 7.6
Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
Query: 82 EDPKFKELVK-VLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQ 140
ED +K++ + W N+ L + L+ DL DG L LLE L+ K++ + Q
Sbjct: 37 EDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMH-RKHNQ 95
Query: 141 SEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHF 193
++ +L+ V A+ L R + +I NL IL L+ +L +H+
Sbjct: 96 RPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHY 148
>gi|116063573 filamin A, alpha isoform 1 [Homo sapiens]
Length = 2639
Score = 38.9 bits (89), Expect = 0.007
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 8/133 (6%)
Query: 229 TTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYL 288
T + M E+D L + AP K + + + + N+HL ++ + L+T +DG+ L
Sbjct: 23 TRDAEMPATEKD----LAEDAPWK-KIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRL 77
Query: 289 VLLMGLLEDYFVPLHHFYLTPESFDQ-KVHNVSFAFELMLDGGLKKPKARPEDVVNLDLK 347
+ L+ +L +H + +F Q ++ NVS A E + +K + +V+ +LK
Sbjct: 78 IALLEVLSQ--KKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLK 135
Query: 348 STLRVLYNLFTKY 360
L +++ L Y
Sbjct: 136 LILGLIWTLILHY 148
Score = 28.9 bits (63), Expect = 7.6
Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
Query: 82 EDPKFKELVK-VLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQ 140
ED +K++ + W N+ L + L+ DL DG L LLE L+ K++ + Q
Sbjct: 37 EDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMH-RKHNQ 95
Query: 141 SEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHF 193
++ +L+ V A+ L R + +I NL IL L+ +L +H+
Sbjct: 96 RPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHY 148
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 38.9 bits (89), Expect = 0.007
Identities = 27/113 (23%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 249 APDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLT 308
A ++ V KK+ +VNKHL K +++L DG L+ L+ +L +P +
Sbjct: 64 ADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 123
Query: 309 PESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYK 361
K+ NV A + + +K R +D+ + + K TL +++ + ++
Sbjct: 124 ----FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 172
Score = 35.8 bits (81), Expect = 0.062
Identities = 35/128 (27%), Positives = 57/128 (44%), Gaps = 13/128 (10%)
Query: 74 TMIDPTSKE-----DPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKL 128
+++DP + D + + K W+N L++ + + L EDL DG L LLE L
Sbjct: 51 SVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL 110
Query: 129 AGCKLNVAEVTQSEIGQKQ--KLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLL 186
+G L E G+ + KLQ V A+ L + + D I N L L+
Sbjct: 111 SGDSL------PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLI 164
Query: 187 VSLAMHFR 194
++ +HF+
Sbjct: 165 WTIILHFQ 172
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 38.5 bits (88), Expect = 0.010
Identities = 28/128 (21%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 237 FERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLE 296
FER L D ++ V KK+ +VN HL +++ +T+L DG L+ L+ +L
Sbjct: 40 FERSRIKALAD---EREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLS 96
Query: 297 DYFVPLHHFYLTPESFDQKVH---NVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVL 353
+P P ++H NV A + + + + D+V+ + + L ++
Sbjct: 97 GEMLP------KPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLI 150
Query: 354 YNLFTKYK 361
+ + +++
Sbjct: 151 WTIILRFQ 158
Score = 32.7 bits (73), Expect = 0.52
Identities = 33/125 (26%), Positives = 53/125 (42%), Gaps = 13/125 (10%)
Query: 91 KVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQ 150
K W+N L + L +DL DG++L KLLE L+G L + I L+
Sbjct: 58 KTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRI---HCLE 114
Query: 151 TVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVV 210
V +A+ L R I N +L L+ ++ + F+ +Q +VV
Sbjct: 115 NVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQ----------IQDIVV 164
Query: 211 RKREG 215
+ +EG
Sbjct: 165 QTQEG 169
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,338,073
Number of Sequences: 37866
Number of extensions: 584442
Number of successful extensions: 2088
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 1987
Number of HSP's gapped (non-prelim): 141
length of query: 364
length of database: 18,247,518
effective HSP length: 104
effective length of query: 260
effective length of database: 14,309,454
effective search space: 3720458040
effective search space used: 3720458040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.