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Search of human proteins with 19923586
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923586 nuclear receptor binding SET domain protein 1
isoform b [Homo sapiens]
(2696 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 5521 0.0
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 4957 0.0
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1051 0.0
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1051 0.0
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1051 0.0
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor... 1051 0.0
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens] 959 0.0
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens] 201 8e-51
gi|197313748 SET domain containing 2 [Homo sapiens] 185 5e-46
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens] 109 4e-23
gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 99 7e-20
gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform ... 99 7e-20
gi|13699813 WHSC1L1 protein isoform short [Homo sapiens] 98 1e-19
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens] 98 1e-19
gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens] 98 1e-19
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens] 97 3e-19
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 92 7e-18
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 91 2e-17
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 87 3e-16
gi|194306650 SET domain and mariner transposase fusion [Homo sap... 86 4e-16
gi|210032580 SET domain containing 1B [Homo sapiens] 86 4e-16
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 84 1e-15
gi|55741677 SET domain containing 1A [Homo sapiens] 84 2e-15
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 83 3e-15
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 83 3e-15
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 75 9e-13
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 72 6e-12
gi|24308089 chromodomain helicase DNA binding protein 5 [Homo sa... 70 2e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 64 3e-09
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 64 3e-09
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 5521 bits (14321), Expect = 0.0
Identities = 2696/2696 (100%), Positives = 2696/2696 (100%)
Query: 1 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNA 60
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNA
Sbjct: 1 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNA 60
Query: 61 YGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGG 120
YGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGG
Sbjct: 61 YGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGG 120
Query: 121 PTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI 180
PTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
Sbjct: 121 PTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI 180
Query: 181 EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQ 240
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQ
Sbjct: 181 EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQ 240
Query: 241 RNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSS 300
RNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSS
Sbjct: 241 RNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSS 300
Query: 301 SSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRP 360
SSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRP
Sbjct: 301 SSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRP 360
Query: 361 YRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSK 420
YRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSK
Sbjct: 361 YRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSK 420
Query: 421 WEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLA 480
WEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLA
Sbjct: 421 WEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLA 480
Query: 481 FDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISG 540
FDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISG
Sbjct: 481 FDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISG 540
Query: 541 DISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALIS 600
DISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALIS
Sbjct: 541 DISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALIS 600
Query: 601 KCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDN 660
KCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDN
Sbjct: 601 KCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDN 660
Query: 661 SVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAE 720
SVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAE
Sbjct: 661 SVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAE 720
Query: 721 PGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHS 780
PGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHS
Sbjct: 721 PGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHS 780
Query: 781 KSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLN 840
KSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLN
Sbjct: 781 KSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLN 840
Query: 841 NMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIP 900
NMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIP
Sbjct: 841 NMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIP 900
Query: 901 IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGG 960
IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGG
Sbjct: 901 IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGG 960
Query: 961 STHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRN 1020
STHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRN
Sbjct: 961 STHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRN 1020
Query: 1021 CGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRG 1080
CGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRG
Sbjct: 1021 CGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRG 1080
Query: 1081 GAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSV 1140
GAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSV
Sbjct: 1081 GAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSV 1140
Query: 1141 MNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGR 1200
MNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGR
Sbjct: 1141 MNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGR 1200
Query: 1201 DEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQA 1260
DEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQA
Sbjct: 1201 DEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQA 1260
Query: 1261 ELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLAR 1320
ELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLAR
Sbjct: 1261 ELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLAR 1320
Query: 1321 GRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPE 1380
GRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPE
Sbjct: 1321 GRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPE 1380
Query: 1381 VSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGH 1440
VSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGH
Sbjct: 1381 VSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGH 1440
Query: 1441 LENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEG 1500
LENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEG
Sbjct: 1441 LENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEG 1500
Query: 1501 ELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEA 1560
ELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEA
Sbjct: 1501 ELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEA 1560
Query: 1561 QCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV 1620
QCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV
Sbjct: 1561 QCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV 1620
Query: 1621 QKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSK 1680
QKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSK
Sbjct: 1621 QKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSK 1680
Query: 1681 ILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPE 1740
ILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPE
Sbjct: 1681 ILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPE 1740
Query: 1741 GNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFG 1800
GNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFG
Sbjct: 1741 GNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFG 1800
Query: 1801 SNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQED 1860
SNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQED
Sbjct: 1801 SNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQED 1860
Query: 1861 RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYEC 1920
RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYEC
Sbjct: 1861 RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYEC 1920
Query: 1921 HPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEE 1980
HPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEE
Sbjct: 1921 HPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEE 1980
Query: 1981 CRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRV 2040
CRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRV
Sbjct: 1981 CRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRV 2040
Query: 2041 GLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFK 2100
GLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFK
Sbjct: 2041 GLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFK 2100
Query: 2101 KKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECP 2160
KKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECP
Sbjct: 2101 KKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECP 2160
Query: 2161 WHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE 2220
WHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE
Sbjct: 2161 WHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE 2220
Query: 2221 YVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPE 2280
YVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPE
Sbjct: 2221 YVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPE 2280
Query: 2281 RPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPS 2340
RPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPS
Sbjct: 2281 RPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPS 2340
Query: 2341 SSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKP 2400
SSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKP
Sbjct: 2341 SSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKP 2400
Query: 2401 QTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLID 2460
QTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLID
Sbjct: 2401 QTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLID 2460
Query: 2461 LTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAA 2520
LTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAA
Sbjct: 2461 LTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAA 2520
Query: 2521 APSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQA 2580
APSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQA
Sbjct: 2521 APSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQA 2580
Query: 2581 KQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIV 2640
KQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIV
Sbjct: 2581 KQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIV 2640
Query: 2641 AGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK 2696
AGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK
Sbjct: 2641 AGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK 2696
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 4957 bits (12859), Expect = 0.0
Identities = 2417/2420 (99%), Positives = 2418/2420 (99%)
Query: 277 SFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPW 336
+ DDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPW
Sbjct: 8 ALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPW 67
Query: 337 WPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELP 396
WPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELP
Sbjct: 68 WPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELP 127
Query: 397 VLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMP 456
VLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMP
Sbjct: 128 VLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMP 187
Query: 457 FEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHI 516
FEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHI
Sbjct: 188 FEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHI 247
Query: 517 QFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN 576
QFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN
Sbjct: 248 QFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN 307
Query: 577 TAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSI 636
TAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSI
Sbjct: 308 TAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSI 367
Query: 637 SICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRV 696
SICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRV
Sbjct: 368 SICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRV 427
Query: 697 KAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFN 756
KAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFN
Sbjct: 428 KAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFN 487
Query: 757 LSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCS 816
LSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCS
Sbjct: 488 LSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCS 547
Query: 817 SDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDV 876
SDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDV
Sbjct: 548 SDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDV 607
Query: 877 SDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSY 936
SDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSY
Sbjct: 608 SDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSY 667
Query: 937 RSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLP 996
RSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLP
Sbjct: 668 RSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLP 727
Query: 997 GLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKL 1056
GLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKL
Sbjct: 728 GLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKL 787
Query: 1057 NQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQ 1116
NQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQ
Sbjct: 788 NQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQ 847
Query: 1117 SDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNR 1176
SDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNR
Sbjct: 848 SDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNR 907
Query: 1177 FKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNV 1236
FKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNV
Sbjct: 908 FKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNV 967
Query: 1237 CDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKK 1296
CDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKK
Sbjct: 968 CDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKK 1027
Query: 1297 KQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPL 1356
KQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPL
Sbjct: 1028 KQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPL 1087
Query: 1357 AQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESN 1416
AQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESN
Sbjct: 1088 AQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESN 1147
Query: 1417 DLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRH 1476
DLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRH
Sbjct: 1148 DLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRH 1207
Query: 1477 AAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERG 1536
AAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERG
Sbjct: 1208 AAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERG 1267
Query: 1537 GGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVC 1596
GGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVC
Sbjct: 1268 GGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVC 1327
Query: 1597 KQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKG 1656
KQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKG
Sbjct: 1328 KQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKG 1387
Query: 1657 RLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEG 1716
RLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEG
Sbjct: 1388 RLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEG 1447
Query: 1717 GSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICH 1776
GSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICH
Sbjct: 1448 GSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICH 1507
Query: 1777 PRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKK 1836
PRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKK
Sbjct: 1508 PRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKK 1567
Query: 1837 ALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCN 1896
ALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCN
Sbjct: 1568 ALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCN 1627
Query: 1897 CKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGL 1956
CKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGL
Sbjct: 1628 CKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGL 1687
Query: 1957 RTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYA 2016
RTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYA
Sbjct: 1688 RTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYA 1747
Query: 2017 RFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPN 2076
RFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPN
Sbjct: 1748 RFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPN 1807
Query: 2077 CSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKP 2136
CSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKP
Sbjct: 1808 CSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKP 1867
Query: 2137 GCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKL 2196
GCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKL
Sbjct: 1868 GCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKL 1927
Query: 2197 DGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPA 2256
DGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPA
Sbjct: 1928 DGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPA 1987
Query: 2257 DTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPL 2316
DTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPL
Sbjct: 1988 DTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPL 2047
Query: 2317 DRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLE 2376
DRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLE
Sbjct: 2048 DRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLE 2107
Query: 2377 KTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKE 2436
KTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKE
Sbjct: 2108 KTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKE 2167
Query: 2437 KALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKG 2496
KALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKG
Sbjct: 2168 KALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKG 2227
Query: 2497 LGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQAS 2556
LGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQAS
Sbjct: 2228 LGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQAS 2287
Query: 2557 GRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKK 2616
GRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKK
Sbjct: 2288 GRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKK 2347
Query: 2617 LVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQN 2676
LVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQN
Sbjct: 2348 LVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQN 2407
Query: 2677 TLPALNQAPSSHKCAESEQK 2696
TLPALNQAPSSHKCAESEQK
Sbjct: 2408 TLPALNQAPSSHKCAESEQK 2427
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1051 bits (2719), Expect = 0.0
Identities = 477/765 (62%), Positives = 582/765 (76%), Gaps = 12/765 (1%)
Query: 1467 KPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP 1526
KP K++ + AA K+ S + +E P P E+ E +
Sbjct: 595 KPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSP---GDEPSESPYESADETQTEV 651
Query: 1527 ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNEC 1586
+ + ERG A KE VCQ CEK G LLLCE CCGAFHL CLGL+ P G+F C+EC
Sbjct: 652 SVSSKKSERGV-TAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSEC 710
Query: 1587 RTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAA 1646
+GIH+CFVCK+S DVKRC++ CGKFYHE CV+KYP TV +++GFRC LH C++CHA+
Sbjct: 711 ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHAS 770
Query: 1647 NPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN 1706
NP+N SKG++MRCVRCPVAYH+ D CLAAG ++ASNSIIC HFT R+G R+H HVN
Sbjct: 771 NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVN 830
Query: 1707 VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGR 1766
VSWCFVCS+GGSLLCC+SCPAAFH +CLNI++P+G+W+CNDC+AGKK H+++I+WVK+G
Sbjct: 831 VSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN 890
Query: 1767 YRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM 1826
YRWWPAE+CHP+ VP NI KM+H++GEFPV FFGS DY WTHQARVFPYMEGD S+ +
Sbjct: 891 YRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQG 950
Query: 1827 GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT 1886
+G+ +K ALQEA ARF E+K Q+E R+ QE +++KPPPYKHIKVN+P G+VQI+T
Sbjct: 951 VRGIGRVFKNALQEAEARFREIKLQREARETQE---SERKPPPYKHIKVNKPYGKVQIYT 1007
Query: 1887 ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEI 1946
AD+SEIP+CNCK TDENPCG DSEC+NRML++ECHP VCPAG CQNQCF+KRQYPE +I
Sbjct: 1008 ADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1947 FRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI 2006
+T +GWGL K DI+KGEFVNEYVGELIDEEEC ARI++A E+DIT+FYMLT+DKDRI
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 2007 IDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG 2066
IDAGPKGNY+RFMNH CQPNCET KW+VNGDTRVGLFA+ DI AGTELTFNYNL+CLGN
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 2067 KTVCKCGAPNCSGFLGVRPKNQP-IATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCG 2125
KTVC+CGA NCSGFLG RPK +++EEK KK KKK + +RR +GE ++ EDECF CG
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTR-RRRAKGEGKRQSEDECFRCG 1246
Query: 2126 DAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQ 2185
D GQLV C + C K YH CL L KRP GKWECPWH CD+CGK + SFC +CP+SFCK+
Sbjct: 1247 DGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKE 1306
Query: 2186 HREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPP 2230
H++G F DGR C EHD G + + + PPP P P
Sbjct: 1307 HQDGTAFSCTPDGRSYCCEHD-LGAASVRSTKTEK--PPPEPGKP 1348
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1051 bits (2719), Expect = 0.0
Identities = 477/765 (62%), Positives = 582/765 (76%), Gaps = 12/765 (1%)
Query: 1467 KPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP 1526
KP K++ + AA K+ S + +E P P E+ E +
Sbjct: 595 KPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSP---GDEPSESPYESADETQTEV 651
Query: 1527 ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNEC 1586
+ + ERG A KE VCQ CEK G LLLCE CCGAFHL CLGL+ P G+F C+EC
Sbjct: 652 SVSSKKSERGV-TAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSEC 710
Query: 1587 RTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAA 1646
+GIH+CFVCK+S DVKRC++ CGKFYHE CV+KYP TV +++GFRC LH C++CHA+
Sbjct: 711 ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHAS 770
Query: 1647 NPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN 1706
NP+N SKG++MRCVRCPVAYH+ D CLAAG ++ASNSIIC HFT R+G R+H HVN
Sbjct: 771 NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVN 830
Query: 1707 VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGR 1766
VSWCFVCS+GGSLLCC+SCPAAFH +CLNI++P+G+W+CNDC+AGKK H+++I+WVK+G
Sbjct: 831 VSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN 890
Query: 1767 YRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM 1826
YRWWPAE+CHP+ VP NI KM+H++GEFPV FFGS DY WTHQARVFPYMEGD S+ +
Sbjct: 891 YRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQG 950
Query: 1827 GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT 1886
+G+ +K ALQEA ARF E+K Q+E R+ QE +++KPPPYKHIKVN+P G+VQI+T
Sbjct: 951 VRGIGRVFKNALQEAEARFREIKLQREARETQE---SERKPPPYKHIKVNKPYGKVQIYT 1007
Query: 1887 ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEI 1946
AD+SEIP+CNCK TDENPCG DSEC+NRML++ECHP VCPAG CQNQCF+KRQYPE +I
Sbjct: 1008 ADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1947 FRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI 2006
+T +GWGL K DI+KGEFVNEYVGELIDEEEC ARI++A E+DIT+FYMLT+DKDRI
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 2007 IDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG 2066
IDAGPKGNY+RFMNH CQPNCET KW+VNGDTRVGLFA+ DI AGTELTFNYNL+CLGN
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 2067 KTVCKCGAPNCSGFLGVRPKNQP-IATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCG 2125
KTVC+CGA NCSGFLG RPK +++EEK KK KKK + +RR +GE ++ EDECF CG
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTR-RRRAKGEGKRQSEDECFRCG 1246
Query: 2126 DAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQ 2185
D GQLV C + C K YH CL L KRP GKWECPWH CD+CGK + SFC +CP+SFCK+
Sbjct: 1247 DGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKE 1306
Query: 2186 HREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPP 2230
H++G F DGR C EHD G + + + PPP P P
Sbjct: 1307 HQDGTAFSCTPDGRSYCCEHD-LGAASVRSTKTEK--PPPEPGKP 1348
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1051 bits (2719), Expect = 0.0
Identities = 477/765 (62%), Positives = 582/765 (76%), Gaps = 12/765 (1%)
Query: 1467 KPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP 1526
KP K++ + AA K+ S + +E P P E+ E +
Sbjct: 595 KPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSP---GDEPSESPYESADETQTEV 651
Query: 1527 ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNEC 1586
+ + ERG A KE VCQ CEK G LLLCE CCGAFHL CLGL+ P G+F C+EC
Sbjct: 652 SVSSKKSERGV-TAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSEC 710
Query: 1587 RTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAA 1646
+GIH+CFVCK+S DVKRC++ CGKFYHE CV+KYP TV +++GFRC LH C++CHA+
Sbjct: 711 ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHAS 770
Query: 1647 NPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN 1706
NP+N SKG++MRCVRCPVAYH+ D CLAAG ++ASNSIIC HFT R+G R+H HVN
Sbjct: 771 NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVN 830
Query: 1707 VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGR 1766
VSWCFVCS+GGSLLCC+SCPAAFH +CLNI++P+G+W+CNDC+AGKK H+++I+WVK+G
Sbjct: 831 VSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN 890
Query: 1767 YRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM 1826
YRWWPAE+CHP+ VP NI KM+H++GEFPV FFGS DY WTHQARVFPYMEGD S+ +
Sbjct: 891 YRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQG 950
Query: 1827 GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT 1886
+G+ +K ALQEA ARF E+K Q+E R+ QE +++KPPPYKHIKVN+P G+VQI+T
Sbjct: 951 VRGIGRVFKNALQEAEARFREIKLQREARETQE---SERKPPPYKHIKVNKPYGKVQIYT 1007
Query: 1887 ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEI 1946
AD+SEIP+CNCK TDENPCG DSEC+NRML++ECHP VCPAG CQNQCF+KRQYPE +I
Sbjct: 1008 ADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1947 FRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI 2006
+T +GWGL K DI+KGEFVNEYVGELIDEEEC ARI++A E+DIT+FYMLT+DKDRI
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 2007 IDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG 2066
IDAGPKGNY+RFMNH CQPNCET KW+VNGDTRVGLFA+ DI AGTELTFNYNL+CLGN
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 2067 KTVCKCGAPNCSGFLGVRPKNQP-IATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCG 2125
KTVC+CGA NCSGFLG RPK +++EEK KK KKK + +RR +GE ++ EDECF CG
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTR-RRRAKGEGKRQSEDECFRCG 1246
Query: 2126 DAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQ 2185
D GQLV C + C K YH CL L KRP GKWECPWH CD+CGK + SFC +CP+SFCK+
Sbjct: 1247 DGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKE 1306
Query: 2186 HREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPP 2230
H++G F DGR C EHD G + + + PPP P P
Sbjct: 1307 HQDGTAFSCTPDGRSYCCEHD-LGAASVRSTKTEK--PPPEPGKP 1348
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1051 bits (2719), Expect = 0.0
Identities = 477/765 (62%), Positives = 582/765 (76%), Gaps = 12/765 (1%)
Query: 1467 KPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP 1526
KP K++ + AA K+ S + +E P P E+ E +
Sbjct: 595 KPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSP---GDEPSESPYESADETQTEV 651
Query: 1527 ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNEC 1586
+ + ERG A KE VCQ CEK G LLLCE CCGAFHL CLGL+ P G+F C+EC
Sbjct: 652 SVSSKKSERGV-TAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSEC 710
Query: 1587 RTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAA 1646
+GIH+CFVCK+S DVKRC++ CGKFYHE CV+KYP TV +++GFRC LH C++CHA+
Sbjct: 711 ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHAS 770
Query: 1647 NPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN 1706
NP+N SKG++MRCVRCPVAYH+ D CLAAG ++ASNSIIC HFT R+G R+H HVN
Sbjct: 771 NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVN 830
Query: 1707 VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGR 1766
VSWCFVCS+GGSLLCC+SCPAAFH +CLNI++P+G+W+CNDC+AGKK H+++I+WVK+G
Sbjct: 831 VSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN 890
Query: 1767 YRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM 1826
YRWWPAE+CHP+ VP NI KM+H++GEFPV FFGS DY WTHQARVFPYMEGD S+ +
Sbjct: 891 YRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQG 950
Query: 1827 GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT 1886
+G+ +K ALQEA ARF E+K Q+E R+ QE +++KPPPYKHIKVN+P G+VQI+T
Sbjct: 951 VRGIGRVFKNALQEAEARFREIKLQREARETQE---SERKPPPYKHIKVNKPYGKVQIYT 1007
Query: 1887 ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEI 1946
AD+SEIP+CNCK TDENPCG DSEC+NRML++ECHP VCPAG CQNQCF+KRQYPE +I
Sbjct: 1008 ADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKI 1067
Query: 1947 FRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI 2006
+T +GWGL K DI+KGEFVNEYVGELIDEEEC ARI++A E+DIT+FYMLT+DKDRI
Sbjct: 1068 IKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI 1127
Query: 2007 IDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG 2066
IDAGPKGNY+RFMNH CQPNCET KW+VNGDTRVGLFA+ DI AGTELTFNYNL+CLGN
Sbjct: 1128 IDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNE 1187
Query: 2067 KTVCKCGAPNCSGFLGVRPKNQP-IATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCG 2125
KTVC+CGA NCSGFLG RPK +++EEK KK KKK + +RR +GE ++ EDECF CG
Sbjct: 1188 KTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTR-RRRAKGEGKRQSEDECFRCG 1246
Query: 2126 DAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQ 2185
D GQLV C + C K YH CL L KRP GKWECPWH CD+CGK + SFC +CP+SFCK+
Sbjct: 1247 DGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKE 1306
Query: 2186 HREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPP 2230
H++G F DGR C EHD G + + + PPP P P
Sbjct: 1307 HQDGTAFSCTPDGRSYCCEHD-LGAASVRSTKTEK--PPPEPGKP 1348
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
Length = 1437
Score = 959 bits (2478), Expect = 0.0
Identities = 468/893 (52%), Positives = 579/893 (64%), Gaps = 73/893 (8%)
Query: 1370 QLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDL 1429
+L +S P P ++ S E + G+ E K+QR+ + ES +K
Sbjct: 542 RLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSES---------EKSTE 592
Query: 1430 GLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFD--KPRKRKRQRHAAAKMQCKKVK 1487
+ KK + +E + T K G ++I D KP K++ + +M +
Sbjct: 593 VVPKKKIKKEQVETVPQATVKTGLQK----GASEISDSCKPLKKRSRASTDVEMTSSAYR 648
Query: 1488 NDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQ 1547
+ S S+ ++ + SP T + V M +S RG G + K+ VCQ
Sbjct: 649 DTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLS---RRGTGMSKKDTVCQ 705
Query: 1548 NCEKLGELLL-CEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRC 1606
CE G+ L+ CE +CC FHLECLGL +P KFIC EC+TG H CF CK SG+DVKRC
Sbjct: 706 ICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRC 765
Query: 1607 LLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPV 1666
+ CGKFYHE CV+K+P + ++KGFRC H C C + ASKGR+MRC+RCPV
Sbjct: 766 SVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPV 824
Query: 1667 AYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCS------------ 1714
AYH+ D C+AAGS +++S +IC NH + N VNV +CFVC+
Sbjct: 825 AYHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPM 881
Query: 1715 -------------------------------------EGGSLLCCDSCPAAFHRECLNID 1737
+GG LLCC+SCPA+FH ECL+I+
Sbjct: 882 FSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIE 941
Query: 1738 IPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVL 1797
+PEG W CNDCKAGKK HY++IVWVK+G YRWWPAEIC+PR+VP NI ++HD+G+FPV
Sbjct: 942 MPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVF 1001
Query: 1798 FFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQL 1857
FFGS+DY W HQ RVFPY+EGD S + ++ T+KKAL+EAA RF+ELKAQ+E ++
Sbjct: 1002 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQ-TSINKTFKKALEEAAKRFQELKAQRESKEA 1060
Query: 1858 QEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLL 1917
E KN +KPPPYKHIK N+ IG+VQI ADLSEIPRCNCK DENPCG++SEC+NRML
Sbjct: 1061 LEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQ 1120
Query: 1918 YECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELID 1977
YECHP VCPAG RCQNQCF+KR YP+ EI +T +RGWGLRTK IKKGEFVNEYVGELID
Sbjct: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELID 1180
Query: 1978 EEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGD 2037
EEECR RI+ A E+ +TNFYMLT+ KDRIIDAGPKGNY+RFMNH C PNCETQKW+VNGD
Sbjct: 1181 EEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGD 1240
Query: 2038 TRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSK 2097
RVGLFAL DI AG ELTFNYNL+CLGNG+T C CGA NCSGFLGVRPK+ +T E+
Sbjct: 1241 VRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKA 1300
Query: 2098 KFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKW 2157
K K +Q +R+ + E + ED CF CGD G+LV C K CPK YH CLNLT+ P GKW
Sbjct: 1301 KNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKW 1360
Query: 2158 ECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGP 2210
ECPWHQCD C A SFCE CP SFCK H +G L S L+GRL C+EHDP P
Sbjct: 1361 ECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
Score = 98.2 bits (243), Expect = 1e-19
Identities = 85/317 (26%), Positives = 134/317 (42%), Gaps = 76/317 (23%)
Query: 118 PGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTED 177
P P ++ P SPE+++K+TKTI+NG FE+ C D
Sbjct: 133 PPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGD----------------- 175
Query: 178 ESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP-LAPQTETQ 236
+ E Q + TKS++ + + + SR KS +P L P+ +
Sbjct: 176 -----LLNEVQASE----HTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPE---E 223
Query: 237 KNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELP 296
+N+ VD +EK EE + Q P
Sbjct: 224 QNRPNERVDTVSEKPR---------------EEPVLKEEAPVQ----------------P 252
Query: 297 GTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS 356
SS T++ ST +K++VGDL+W+K PWWPC + SDP + H+K+
Sbjct: 253 ILSSVPTTEV---------STGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI--- 300
Query: 357 NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL--PVLRRRGKQKEK-GYRHKV 413
N R R+Y+V+ F + ERAWV K + ++G Q+EEL ++ EK R
Sbjct: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
Query: 414 PQKILSKWEASVGLAEQ 430
PQ+ ++W+ + AE+
Sbjct: 361 PQRERAQWDIGIAHAEK 377
Score = 40.0 bits (92), Expect = 0.031
Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 1747 DCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSN-DYL 1805
+ G K ++VW KVG Y WWP + + + E+ V FF + +
Sbjct: 261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320
Query: 1806 WTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQK 1852
W H+ RV Y K K + +A ++A+ E+ K +K
Sbjct: 321 WVHEKRVREY---------KGHKQYEELLAEATKQASNHSEKQKIRK 358
>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
Length = 2964
Score = 201 bits (511), Expect = 8e-51
Identities = 111/272 (40%), Positives = 163/272 (59%), Gaps = 26/272 (9%)
Query: 1865 KKP--PPYKHIKVNRPIGRVQIFTADLS--EIPRCNCKATDENPC-GIDSECINRMLLYE 1919
KKP P YK I+ N V + LS E CNCK D++ G +C+NRM+ E
Sbjct: 2062 KKPDVPLYKKIRSN-----VYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAE 2116
Query: 1920 CHPTVCPAGGRCQNQCFSKRQYPE-VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDE 1978
C P CP G +C NQ + ++ + +E FR ++GWG+RTK +K G+F+ EY+GE++ E
Sbjct: 2117 CSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSE 2176
Query: 1979 EECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDT 2038
+E R R+ Q H+ ++ Y L LD +ID+ GN ARF+NH C PNCE QKWSVNG
Sbjct: 2177 QEFRNRM-IEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVY 2235
Query: 2039 RVGLFALSDIKAGTELTFNYNLECLGNGK-TVCKCGAPNCSGFLGVRPK----------N 2087
R+GL+AL D+ AGTELT++YN K +CKCG C G +G + + +
Sbjct: 2236 RIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNS 2295
Query: 2088 QPIATEEKSKKFKKKQQGK---RRTQGEITKE 2116
QP+AT +KS + K+K++ K ++ +G +++E
Sbjct: 2296 QPMATHKKSGRSKEKRKSKHKLKKRRGHLSEE 2327
>gi|197313748 SET domain containing 2 [Homo sapiens]
Length = 2564
Score = 185 bits (470), Expect = 5e-46
Identities = 101/244 (41%), Positives = 143/244 (58%), Gaps = 11/244 (4%)
Query: 1871 KHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGR 1930
K K +R I R+Q LS+ R A E CG D C+NR+L+ EC CP G
Sbjct: 1486 KKNKSHRDIKRMQCECTPLSKDER----AQGEIACGED--CLNRLLMIECSSR-CPNGDY 1538
Query: 1931 CQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIR-YAQ 1989
C N+ F ++Q+ +VE+ T ++GWGLR D+ FV EY GE++D +E +AR++ YA+
Sbjct: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
Query: 1990 EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIK 2049
+I ++Y + L D IIDA KGN +RFMNH C+PNCETQKW+VNG RVG F +
Sbjct: 1599 NKNI-HYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP 1657
Query: 2050 AGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT 2109
+G+ELTF+Y + G C CG+ NC G+LG +N+ K K++ + K
Sbjct: 1658 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLG--GENRVSIRAAGGKMKKERSRKKDSV 1715
Query: 2110 QGEI 2113
GE+
Sbjct: 1716 DGEL 1719
>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
Length = 350
Score = 109 bits (272), Expect = 4e-23
Identities = 69/185 (37%), Positives = 94/185 (50%), Gaps = 21/185 (11%)
Query: 1917 LYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQ-RGWGLRTKTDIKKGEFVNEYVGEL 1975
+YEC+ C G C N+ K + IFRT RGWG++T IK+ FV EYVGE+
Sbjct: 166 IYECNSR-CQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEV 224
Query: 1976 IDEEECRARIRYAQEHDITNFYMLTLDKDRI-IDAGPKGNYARFMNHCCQPNCETQKWSV 2034
I EE R ++ IT + L + D +DA GN + F+NH C PN + +
Sbjct: 225 ITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFI 284
Query: 2035 -NGDT---RVGLFALSDIKAGTELTFNYNLECLGN--------------GKTVCKCGAPN 2076
N DT R+ LF+ I AG ELTF+Y ++ G+ +TVCKCGA
Sbjct: 285 DNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVT 344
Query: 2077 CSGFL 2081
C G+L
Sbjct: 345 CRGYL 349
>gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform 3
[Homo sapiens]
Length = 647
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform 4
[Homo sapiens]
Length = 629
Score = 98.6 bits (244), Expect = 7e-20
Identities = 52/143 (36%), Positives = 84/143 (58%), Gaps = 16/143 (11%)
Query: 300 SSSTSQELPFCQPKKKSTP---------LKYEVGDLIWAKFKRRPWWPCRICSDPLINTH 350
SS + +++P KK+S P LKY VGDL+W+K PWWPC + +DPL++++
Sbjct: 193 SSPSDKKIP---AKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSY 249
Query: 351 SKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL---PVLRRRGKQKEK 407
+K+K ++ RQY+V+ FGD ERAW+ K++V FEG QFE+L + K ++
Sbjct: 250 TKLK-GQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKI 308
Query: 408 GYRHKVPQKILSKWEASVGLAEQ 430
+ K+ ++WE + AE+
Sbjct: 309 KLLKPISGKLRAQWEMGIVQAEE 331
Score = 39.3 bits (90), Expect = 0.053
Identities = 55/213 (25%), Positives = 83/213 (38%), Gaps = 36/213 (16%)
Query: 24 APEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-------GTSQNAYGQDSPSCYIPLRRLQ 76
APE S NG++ E C++ LS G Q G D+ +IP +L+
Sbjct: 24 APEILGS--ANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALP-FIPADKLK 80
Query: 77 DLASMI-NVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNS 135
DL S + N E G+ D F+ E TP T P N S
Sbjct: 81 DLTSRVFNGE--PGAHDAKLRFESQEMKG--IGTPPNTT---------------PIKNGS 121
Query: 136 PELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNY 195
PE+++K+TKT NG FE+ C D A S+ + E+++ + Y
Sbjct: 122 PEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKA------RRNRKRSIKY 175
Query: 196 ETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP 228
++ E G+ A + S+P + K P
Sbjct: 176 DSLLEQGLVEAALVSKISSPSDKKIPAKKESCP 208
>gi|13699813 WHSC1L1 protein isoform short [Homo sapiens]
Length = 645
Score = 98.2 bits (243), Expect = 1e-19
Identities = 85/317 (26%), Positives = 134/317 (42%), Gaps = 76/317 (23%)
Query: 118 PGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTED 177
P P ++ P SPE+++K+TKTI+NG FE+ C D
Sbjct: 133 PPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGD----------------- 175
Query: 178 ESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP-LAPQTETQ 236
+ E Q + TKS++ + + + SR KS +P L P+ +
Sbjct: 176 -----LLNEVQASE----HTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPE---E 223
Query: 237 KNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELP 296
+N+ VD +EK EE + Q P
Sbjct: 224 QNRPNERVDTVSEKPR---------------EEPVLKEEAPVQ----------------P 252
Query: 297 GTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS 356
SS T++ ST +K++VGDL+W+K PWWPC + SDP + H+K+
Sbjct: 253 ILSSVPTTEV---------STGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI--- 300
Query: 357 NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL--PVLRRRGKQKEK-GYRHKV 413
N R R+Y+V+ F + ERAWV K + ++G Q+EEL ++ EK R
Sbjct: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
Query: 414 PQKILSKWEASVGLAEQ 430
PQ+ ++W+ + AE+
Sbjct: 361 PQRERAQWDIGIAHAEK 377
Score = 40.0 bits (92), Expect = 0.031
Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 1747 DCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSN-DYL 1805
+ G K ++VW KVG Y WWP + + + E+ V FF + +
Sbjct: 261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320
Query: 1806 WTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQK 1852
W H+ RV Y K K + +A ++A+ E+ K +K
Sbjct: 321 WVHEKRVREY---------KGHKQYEELLAEATKQASNHSEKQKIRK 358
>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
Length = 707
Score = 97.8 bits (242), Expect = 1e-19
Identities = 57/182 (31%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 1890 SEIPRCNCKA---TDENPCGIDSECINRMLLYECHPTVCPAGGR----------CQNQCF 1936
+ P C CKA T + PC + + EC P +C G C+N
Sbjct: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
Query: 1937 SKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNF 1996
+ + + + GWG+ K ++K EF++EY GE+I ++E R + ++ +
Sbjct: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-- 625
Query: 1997 YMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTF 2056
++ L+ D ++DA KGN RF NH PNC + VNGD R+G+FA I+ G EL F
Sbjct: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
Query: 2057 NY 2058
+Y
Sbjct: 686 DY 687
>gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens]
Length = 751
Score = 97.8 bits (242), Expect = 1e-19
Identities = 57/182 (31%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 1890 SEIPRCNCKA---TDENPCGIDSECINRMLLYECHPTVCPAGGR----------CQNQCF 1936
+ P C CKA T + PC + + EC P +C G C+N
Sbjct: 560 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 611
Query: 1937 SKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNF 1996
+ + + + GWG+ K ++K EF++EY GE+I ++E R + ++ +
Sbjct: 612 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-- 669
Query: 1997 YMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTF 2056
++ L+ D ++DA KGN RF NH PNC + VNGD R+G+FA I+ G EL F
Sbjct: 670 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 729
Query: 2057 NY 2058
+Y
Sbjct: 730 DY 731
>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
Length = 747
Score = 96.7 bits (239), Expect = 3e-19
Identities = 59/182 (32%), Positives = 88/182 (48%), Gaps = 23/182 (12%)
Query: 1890 SEIPRCNCKA---TDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEI 1946
+ P C CK T + PC + + EC P +C G ++ I
Sbjct: 556 NRFPGCRCKTQCNTKQCPC--------YLAVRECDPDLCLTCGASEHWDCKVVSCKNCSI 607
Query: 1947 FRTLQR----------GWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNF 1996
R L++ GWG K ++K EF++EY GELI ++E R + ++ +
Sbjct: 608 QRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKY--MSS 665
Query: 1997 YMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTF 2056
++ L+ D ++DA KGN RF NH PNC + VNGD R+G+FA I+AG EL F
Sbjct: 666 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFF 725
Query: 2057 NY 2058
+Y
Sbjct: 726 DY 727
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 92.0 bits (227), Expect = 7e-18
Identities = 50/139 (35%), Positives = 73/139 (52%), Gaps = 2/139 (1%)
Query: 1944 VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDK 2003
V ++R+ G GL K +I GE V EY G +I + R +Y I YM +D
Sbjct: 3831 VGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGI-GCYMFRIDD 3889
Query: 2004 DRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL 2063
++DA GN ARF+NH C+PNC ++ +++G + +FA+ I G ELT++Y
Sbjct: 3890 SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE 3949
Query: 2064 -GNGKTVCKCGAPNCSGFL 2081
+ K C CGA C FL
Sbjct: 3950 DASNKLPCNCGAKKCRKFL 3968
Score = 44.7 bits (104), Expect = 0.001
Identities = 51/190 (26%), Positives = 73/190 (38%), Gaps = 18/190 (9%)
Query: 1466 DKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVE-EGVEHDPG 1524
+KP +Q +A + N +SSK+ ++G HR KE E E V G
Sbjct: 1363 EKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGV---HRIRVDFKEDCEAENVWEMGG 1419
Query: 1525 MPASKKMQGERGGGAALKENVCQNCEKLG--ELLLCEAQCCGAFHLECLGLTEMPRGKFI 1582
+ G VC C G E + C+ CC FH CL E P +
Sbjct: 1420 L-------GILTSVPITPRVVCFLCASSGHVEFVYCQV-CCEPFHKFCLEENERPLEDQL 1471
Query: 1583 CNECRTGIHTCFVCKQSGEDVKRCL-LPLCGKFYHEECVQKYPPT--VMQNKGFRCSLHI 1639
N C C VC + + K+ L C YH EC+ PT + K + C+ +
Sbjct: 1472 ENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCV 1531
Query: 1640 -CITCHAANP 1648
C +C + P
Sbjct: 1532 RCKSCGSTTP 1541
Score = 33.9 bits (76), Expect = 2.2
Identities = 76/374 (20%), Positives = 139/374 (37%), Gaps = 45/374 (12%)
Query: 2232 PSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQ 2291
PS+ + ST +DK P ++ SL KKA A C+ + + L++TD +P+
Sbjct: 994 PSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCK--IEKSKSLKQTD-QPK 1050
Query: 2292 PLDKVRDLAGSGTKSQSLVSSQR-------------PLDRPPAVAGP---RPQLSDKPSP 2335
+ D + + + + R P D P A P R ++
Sbjct: 1051 AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGN 1110
Query: 2336 VTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASP--RPQSLEKTSVPTGLRLPPPDRLL 2393
S + S ++PL P+ P P + + + G ++P +
Sbjct: 1111 DDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC 1170
Query: 2394 ITSSPKPQTSDRPTDKPHASLSQ----RLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSK 2449
KP+ R K + + + P + L + + KEK + ++ +
Sbjct: 1171 TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEK--KDS 1228
Query: 2450 NRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCV 2509
+++V +++D S + TP A E +SSS P + + E+G V
Sbjct: 1229 KESSVVKNVVD----------SSQKPTPSAREDPAPKKSSSEPPPR--KPVEEKSEEGNV 1276
Query: 2510 SDPLQTSGKAAAPSEDPWQAVKSLTQARLL--SQPPAKAFLYEPTTQASGRASAGAEQTP 2567
S P S +A P+ ++ K ++Q L+ QPP + + + S ++ P
Sbjct: 1277 SAPGPESKQATTPASR--KSSKQVSQPALVIPPQPPTTGPPRKEVPKTT--PSEPKKKQP 1332
Query: 2568 GPLSQSPGLVKQAK 2581
P P KQ K
Sbjct: 1333 PPPESGPEQSKQKK 1346
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 90.9 bits (224), Expect = 2e-17
Identities = 56/151 (37%), Positives = 78/151 (51%), Gaps = 7/151 (4%)
Query: 1917 LYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQ-RGWGLRTKTDIKKGEFVNEYVGEL 1975
+YEC+ C G C N+ K ++ IFRT RGWG+RT I+K FV EYVGE+
Sbjct: 219 IYECNSR-CRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEI 277
Query: 1976 IDEEECRARIRYAQEHDITNFYMLTLDKD-RIIDAGPKGNYARFMNHCCQPNCETQKWSV 2034
I EE R + T + L +D +DA GN + F+NH C PN + +
Sbjct: 278 ITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFI 337
Query: 2035 NG----DTRVGLFALSDIKAGTELTFNYNLE 2061
+ R+ FA I+AG ELTF+YN++
Sbjct: 338 DNLDERLPRIAFFATRTIRAGEELTFDYNMQ 368
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 86.7 bits (213), Expect = 3e-16
Identities = 61/188 (32%), Positives = 90/188 (47%), Gaps = 17/188 (9%)
Query: 1916 LLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGEL 1975
L++EC+ C C+N+ ++++RT GWG+R+ DI G FV EYVGEL
Sbjct: 1101 LIFECNHA-CSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGEL 1159
Query: 1976 IDEEECRARIRYAQEHDITNFYMLTLDKD---RIIDAGPKGNYARFMNHCCQPN-CETQK 2031
I + E R + D+ N KD IDA GN +RF+NH C+PN +
Sbjct: 1160 ISDSEADVREEDSYLFDLDN-------KDGEVYCIDARFYGNVSRFINHHCEPNLVPVRV 1212
Query: 2032 WSVNGD---TRVGLFALSDIKAGTELTFNYNLECLG-NGKTV-CKCGAPNCSGFLGVRPK 2086
+ + D R+ F+ I+AG +L F+Y GK C+CG+P C +
Sbjct: 1213 FMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQ 1272
Query: 2087 NQPIATEE 2094
Q A +E
Sbjct: 1273 RQASAAQE 1280
>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
Length = 684
Score = 86.3 bits (212), Expect = 4e-16
Identities = 57/186 (30%), Positives = 91/186 (48%), Gaps = 23/186 (12%)
Query: 1917 LYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI 1976
++EC+ +C C+N+ K ++F+T ++GWGLRT I KG FV EY GE++
Sbjct: 115 VFECN-VLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVL 173
Query: 1977 DEEECRARIRYAQEHDITNFYMLTLD-------KDRIIDAGPKGNYARFMNHCCQPNCET 2029
E + RI + D +N+ + + + +D GN RF+NH C+PN
Sbjct: 174 GFSEVQRRIHLQTKSD-SNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLM 232
Query: 2030 QKWSVNGDT-RVGLFALSDIKAGTELTFNY-----------NLECLGNGK--TVCKCGAP 2075
++ ++ LFA DI EL+++Y + E L +GK C CGA
Sbjct: 233 IPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAK 292
Query: 2076 NCSGFL 2081
+C+ FL
Sbjct: 293 SCTAFL 298
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 86.3 bits (212), Expect = 4e-16
Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 1/128 (0%)
Query: 1954 WGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKG 2013
WGL I E V EYVG+ I + R + ++ I + YM +D D IIDA G
Sbjct: 1796 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCG 1855
Query: 2014 NYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCG 2073
N+ARF+NH C PNC + +V ++ +++ I E+T++Y + + K C CG
Sbjct: 1856 NFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFP-IEDVKIPCLCG 1914
Query: 2074 APNCSGFL 2081
+ NC G L
Sbjct: 1915 SENCRGTL 1922
Score = 35.0 bits (79), Expect = 1.00
Identities = 51/184 (27%), Positives = 66/184 (35%), Gaps = 26/184 (14%)
Query: 2246 QAPKMSDKPP--------ADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVR 2297
+ P M D+PP AD+ + + L+ L PE P + ++RP PL R
Sbjct: 1202 ERPSMLDEPPLPVGVEEPADSRE--PPEEPGLSQEGAMLLSPEPPAKEVEARP-PLSPER 1258
Query: 2298 ----DLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQL--SDKPSPVTSPSSSPSVRSQPLE 2351
DL L PL P + PRP S P P T+ +S PSV +PL
Sbjct: 1259 APEHDLEVEPEPPMML-----PLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLA 1313
Query: 2352 RPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPH 2411
P L S+ + QS E G P S PQ P P
Sbjct: 1314 EDHPPHTPGLCGSLA----KSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPA 1369
Query: 2412 ASLS 2415
S S
Sbjct: 1370 PSPS 1373
Score = 34.3 bits (77), Expect = 1.7
Identities = 73/313 (23%), Positives = 110/313 (35%), Gaps = 62/313 (19%)
Query: 2226 VPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRP--------- 2276
VP PG L+ S+G++ +P++ P + SLS L T R
Sbjct: 1336 VPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSE 1395
Query: 2277 -----LLPERPLE--RTDSR----------------PQPLDKVRDLA-GSGTKSQSLVSS 2312
LLP PL R D R P PL LA + ++Q+ +
Sbjct: 1396 PSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPT 1455
Query: 2313 QRPLDRPPAVAGPRPQLSDKPS-PVTSPSSSPSVRSQPLERPLGTA----------DPRL 2361
P P +A P + KP P SP S S+ + P G A P+
Sbjct: 1456 PLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQT 1515
Query: 2362 DKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASL-----SQ 2416
PR +L+ + G+ PPP P P PT P L S+
Sbjct: 1516 PVFPSTHDPRTVTLDFRN--AGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSE 1573
Query: 2417 RLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQ-- 2474
+PP + V + + K+ P + + ++ DL P SP Q
Sbjct: 1574 AIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHE--------DLVPPAGSPELSPPQPL 1625
Query: 2475 VTPQAD-EKMPVL 2486
P+++ E+M +L
Sbjct: 1626 FRPRSEFEEMTIL 1638
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 84.3 bits (207), Expect = 1e-15
Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 2/139 (1%)
Query: 1944 VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDK 2003
V ++R+ G GL K +I GE V EY G +I R ++ I YM +D
Sbjct: 2577 VGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGI-GCYMFRMDD 2635
Query: 2004 DRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL 2063
++DA GN ARF+NH C+PNC ++ V G + +FAL I G ELT++Y
Sbjct: 2636 FDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIE 2695
Query: 2064 -GNGKTVCKCGAPNCSGFL 2081
+ K C CGA C FL
Sbjct: 2696 DASNKLPCNCGAKRCRRFL 2714
Score = 49.3 bits (116), Expect = 5e-05
Identities = 40/137 (29%), Positives = 52/137 (37%), Gaps = 8/137 (5%)
Query: 1545 VCQNCEKLG--ELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGED 1602
VC C G EL+ C+ CC FH CL E P + C C VC + G
Sbjct: 1203 VCLLCASKGLHELVFCQV-CCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRG 1261
Query: 1603 VKRCL-LPLCGKFYHEECVQKYPPT--VMQNKGFRCSLHI-CITCHAANPANVSAS-KGR 1657
K L C YH C+ PT + + + CS + C +C A N G
Sbjct: 1262 SKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGD 1321
Query: 1658 LMRCVRCPVAYHANDFC 1674
C RC Y ++C
Sbjct: 1322 YSLCPRCTQLYEKGNYC 1338
Score = 46.6 bits (109), Expect = 3e-04
Identities = 99/433 (22%), Positives = 143/433 (33%), Gaps = 55/433 (12%)
Query: 2188 EGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQA 2247
E M K + +L P P+P P PPP PP P +
Sbjct: 389 EMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPP---------VSPP 439
Query: 2248 PKMSDKPPADTNQMLSLSKKALAGTCQR-----PLLPERPLERTDSRPQPLDKVRDLAGS 2302
P S PP + + TC R PL P + ER +R P +
Sbjct: 440 PLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGP-----EGTSP 494
Query: 2303 GTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPS---PVTSPSSSPSVRS-------QPLER 2352
T + S + P D P L + PV S SS +++ P +
Sbjct: 495 PTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKP 554
Query: 2353 PLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHA 2412
P P L I + P PQ E VP+ R P P + K ++ R
Sbjct: 555 PKVEVSPVLRPPITTSPPVPQ--EPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWT 612
Query: 2413 SLSQRLPPPEKV-------LSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQ 2465
SL++ LPPP ++ L Q T S+ + + LTP
Sbjct: 613 SLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESV--LTPPP 670
Query: 2466 KERAASPHQVTPQADEKMPVLESSSWPASKGLG---HMPRAVEKGCVSDPLQTSGKAAAP 2522
+P P AD +S + P + +G H+ V+ P++ +P
Sbjct: 671 LGAPEAPEPEPPPAD------DSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAE---VSP 721
Query: 2523 SEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQ 2582
P + TQA+LL P +A + QA + P P Q P L K
Sbjct: 722 HGAPALSNGPQTQAQLLQ--PLQALQTQLLPQALPPPQPQLQPPPSP-QQMPPLEKARIA 778
Query: 2583 MVGGQQLPALAAK 2595
VG L + K
Sbjct: 779 GVGSLPLSGVEEK 791
Score = 36.2 bits (82), Expect = 0.45
Identities = 53/223 (23%), Positives = 73/223 (32%), Gaps = 48/223 (21%)
Query: 2191 LFISKLDGRLSC------TEHDPCGPNP----LEPGEIREYV---PPPVPLPPGPSTHLA 2237
L+ S +D R C E+ P GP LE E + + P P PPG
Sbjct: 1763 LYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPG------ 1816
Query: 2238 EQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVR 2297
+ PP DT+ ++ + + P+ P R DS P R
Sbjct: 1817 -------------GEDPPLDTDVLVPGAPER-----HSPIQNLDPPLRPDSGSAPPPAPR 1858
Query: 2298 DLAGSGTKSQSLVSSQRPLD-----------RPPAVAGPRPQLSDKPSPVTSPSSSPSVR 2346
+G+ K + S+RPL P ++ P + D P S
Sbjct: 1859 SFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSP 1918
Query: 2347 SQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPP 2389
P P A P L S P P S+ PT L PP
Sbjct: 1919 LAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPP 1961
Score = 32.3 bits (72), Expect = 6.5
Identities = 44/185 (23%), Positives = 61/185 (32%), Gaps = 28/185 (15%)
Query: 2256 ADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRP 2315
A +M+ ++K A PL P P S P PL S + L P
Sbjct: 385 AVAEEMMPAAEKEEAKLPPPPLTPPAP-----SPPPPLPPP-----STSPPPPLCPPPPP 434
Query: 2316 LDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSL 2375
PP + P P + + + P P+ S+ RP T R ++ A P S
Sbjct: 435 PVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSP 494
Query: 2376 EKTSVPTGLRLPPPDRLLITSSPKPQT----------------SDRPTDKPHASLSQRLP 2419
+ T PP D T +PK T S R P + + P
Sbjct: 495 PTPTPSTATGGPPEDS--PTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPP 552
Query: 2420 PPEKV 2424
P KV
Sbjct: 553 KPPKV 557
Score = 32.3 bits (72), Expect = 6.5
Identities = 34/122 (27%), Positives = 44/122 (36%), Gaps = 36/122 (29%)
Query: 1639 ICITCHAANPANVSASKG--RLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPR 1696
+C+ C ASKG L+ C C +H FCL + L P H
Sbjct: 1203 VCLLC---------ASKGLHELVFCQVCCDPFHP--FCLEEAERPL-------PQHHDTW 1244
Query: 1697 RGCRNHEHVNVSWCFVCSEGGS----LLCCDSCPAAFHRECLNIDIP------EGNWYCN 1746
CR +C VC G LL C+ C A+H CL P +W C+
Sbjct: 1245 C-CRR-----CKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICS 1298
Query: 1747 DC 1748
C
Sbjct: 1299 AC 1300
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 84.0 bits (206), Expect = 2e-15
Identities = 44/128 (34%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
Query: 1954 WGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKG 2013
WGL I E V EYVG+ I + R + + I + Y+ +D D IIDA G
Sbjct: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
Query: 2014 NYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCG 2073
N ARF+NHCC PNC + ++ ++ +++ I E+T++Y L + K C CG
Sbjct: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
Query: 2074 APNCSGFL 2081
+C G L
Sbjct: 1699 TESCRGSL 1706
Score = 36.2 bits (82), Expect = 0.45
Identities = 59/250 (23%), Positives = 92/250 (36%), Gaps = 43/250 (17%)
Query: 2300 AGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSP----------------SSSP 2343
+ S + S+ +RP P A PR P+PV P +SP
Sbjct: 1056 SSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
Query: 2344 SVRSQPLERPLGTADPR-LDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQT 2402
+ + P E +A R + G +P P+ E+ S P L PP R S +
Sbjct: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEV 1175
Query: 2403 SDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQS--KNRAALVMDLID 2460
P P + P P A KA R V++ ++ + A+LV +
Sbjct: 1176 VPAPEPPPATPPQAKFPGP------------ASRKAPRGVERTIRNLPLDHASLVKSWPE 1223
Query: 2461 LTPR-------QKERAASPHQVTPQADEKMPVL-ESSSWPASKGLGHMPRAVEKGCVSDP 2512
R + R + P + + VL + + PA +GL +P AVE S+
Sbjct: 1224 EVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALP-AVED---SEA 1279
Query: 2513 LQTSGKAAAP 2522
+TS +A P
Sbjct: 1280 TETSDEAERP 1289
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
b [Homo sapiens]
Length = 1176
Score = 83.2 bits (204), Expect = 3e-15
Identities = 69/239 (28%), Positives = 107/239 (44%), Gaps = 38/239 (15%)
Query: 1867 PPPYKHIKVNRPIGRVQIFTADLSEIPRCNCK---ATDENPCG-IDSEC----------- 1911
P YK+I N + I +++ + C C ++ CG + C
Sbjct: 913 PEDYKYISENCETSTMNI-DRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQE 971
Query: 1912 ---INRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFV 1968
I L++EC+ C C+N+ ++++RT + GWG+R I +G F+
Sbjct: 972 FNKIEPPLIFECNQA-CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFI 1030
Query: 1969 NEYVGELIDEEECRARIRYAQEHDITNFYMLTLD-KD---RIIDAGPKGNYARFMNHCCQ 2024
EYVGELI + E R E D Y+ LD KD IDA GN +RF+NH C
Sbjct: 1031 CEYVGELISDAEADVR-----EDD---SYLFDLDNKDGEVYCIDARYYGNISRFINHLCD 1082
Query: 2025 PN-CETQKWSVNGD---TRVGLFALSDIKAGTELTFNY--NLECLGNGKTVCKCGAPNC 2077
PN + + ++ D R+ F+ DI+ G EL F+Y + + C+CG+ C
Sbjct: 1083 PNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC 1141
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
a [Homo sapiens]
Length = 1210
Score = 83.2 bits (204), Expect = 3e-15
Identities = 69/239 (28%), Positives = 107/239 (44%), Gaps = 38/239 (15%)
Query: 1867 PPPYKHIKVNRPIGRVQIFTADLSEIPRCNCK---ATDENPCG-IDSEC----------- 1911
P YK+I N + I +++ + C C ++ CG + C
Sbjct: 947 PEDYKYISENCETSTMNI-DRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQE 1005
Query: 1912 ---INRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFV 1968
I L++EC+ C C+N+ ++++RT + GWG+R I +G F+
Sbjct: 1006 FNKIEPPLIFECNQA-CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFI 1064
Query: 1969 NEYVGELIDEEECRARIRYAQEHDITNFYMLTLD-KD---RIIDAGPKGNYARFMNHCCQ 2024
EYVGELI + E R E D Y+ LD KD IDA GN +RF+NH C
Sbjct: 1065 CEYVGELISDAEADVR-----EDD---SYLFDLDNKDGEVYCIDARYYGNISRFINHLCD 1116
Query: 2025 PN-CETQKWSVNGD---TRVGLFALSDIKAGTELTFNY--NLECLGNGKTVCKCGAPNC 2077
PN + + ++ D R+ F+ DI+ G EL F+Y + + C+CG+ C
Sbjct: 1117 PNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC 1175
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 75.1 bits (183), Expect = 9e-13
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 2/135 (1%)
Query: 1944 VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDK 2003
V + R+ +G GL D++K V EY+G +I E R + +E + YM ++
Sbjct: 5399 VYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQN-RGIYMFRINN 5457
Query: 2004 DRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL 2063
+ +IDA G AR++NH C PNC + + + + ++ + + I G ELT++Y +
Sbjct: 5458 EHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFE 5517
Query: 2064 GN-GKTVCKCGAPNC 2077
+ K C CGA NC
Sbjct: 5518 DDQHKIPCHCGAWNC 5532
Score = 57.8 bits (138), Expect = 1e-07
Identities = 113/533 (21%), Positives = 173/533 (32%), Gaps = 86/533 (16%)
Query: 2121 CFSCGDAGQLVSCKKPGCPKVYHADCL----NLTKRPAGKWECPWH----------QCDI 2166
C C G + C+ PGCP++YH C + + CP H +C +
Sbjct: 172 CSHCTRLGASIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAYLEEARCAV 231
Query: 2167 CGKEAASFCEMCPSSFCKQHREGMLFISKLDGR----LSCTEHDPCGP------------ 2210
C + C++ + C H G + L R C E C
Sbjct: 232 C-EGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLV 290
Query: 2211 -NPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSL---SK 2266
+ G + PP+ P S A A P ++ + SL
Sbjct: 291 CETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCH 350
Query: 2267 KALAGTCQRPLLPER-PLERTDSRPQPLDKVRD------LAGSGTKSQSLVSSQRPLD-- 2317
KA G R + + P+ S P+P D D +A G V+S +P +
Sbjct: 351 KAQGGQTIRSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPG 410
Query: 2318 ------RPPAVAGPR--PQLS---DKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIG 2366
+P AG + PQL ++ P+ P + P E P T+ P
Sbjct: 411 PLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESP--TSPP---PEAS 465
Query: 2367 AASPRPQSLEKTSVPTGLRL----------PPPDRLLIT----SSPKPQTSDRPTDKPHA 2412
SP P+ L + +P L L PPP+ ++ SSP + P P
Sbjct: 466 RLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEE 525
Query: 2413 S-----LSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKE 2467
S L L PP + S + + P + T A+ + + +P
Sbjct: 526 SPPSPALETPLSPPPEA-SPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPP 584
Query: 2468 RAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPW 2527
SP P+A P E S + E +S P + S + P E P
Sbjct: 585 PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPM 644
Query: 2528 ------QAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSP 2574
+ L LS PP ++ L P ++ A + P SP
Sbjct: 645 SPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSP 697
Score = 50.8 bits (120), Expect = 2e-05
Identities = 37/116 (31%), Positives = 51/116 (43%), Gaps = 10/116 (8%)
Query: 1537 GGAALKENVCQNCEKLGEL--LLCEAQCCGAFHLECL--GLTEMPRGKFICNECRTGIHT 1592
G A L+E C CE GEL L C +H CL LT R + C EC+
Sbjct: 220 GAAYLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKV---- 275
Query: 1593 CFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRC-SLHICITCHAAN 1647
C C++ G D K + C K YH C+ K P + ++C + +C C A +
Sbjct: 276 CQACRKPGNDSKMLVCETCDKGYHTFCL-KPPMEELPAHSWKCKACRVCRACGAGS 330
Score = 46.6 bits (109), Expect = 3e-04
Identities = 80/304 (26%), Positives = 109/304 (35%), Gaps = 52/304 (17%)
Query: 2204 EHDPCGPNPLE-----PGEIREYVP-------PPVPLPPGPSTHLAEQSTGMAAQ-APKM 2250
E P P P E P E + P PP PP P+ A+ +P
Sbjct: 490 EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF 549
Query: 2251 SDKPPADTNQMLSLSKKALAGTCQRPLLPER-----PLERTDSRPQPLDKVRDLAGSGTK 2305
+ P + + L S A P PE P E + P P + R
Sbjct: 550 EESPLSPPPEELPTSPPPEASRLSPP--PEESPMSPPPEESPMSPPP-EASRLFPPFEES 606
Query: 2306 SQSLVSSQRPLDRPPAVAGPRPQLSDKPS---PVTSPSSSPSVRSQPLERPL-GTADPRL 2361
S + PL PP + P D P P SP S P S+ P+ P
Sbjct: 607 PLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPP 666
Query: 2362 DKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPP 2421
++S SP P+ + P RL PP SP TS P D P + PPP
Sbjct: 667 EES--PLSPPPEESPTSPPPEASRLSPPPE----DSP---TSPPPEDSPAS------PPP 711
Query: 2422 EKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPH----QVTP 2477
E L +L +E L P+ + Q R+ + L+PR +E SP ++P
Sbjct: 712 EDSL----MSLPLEESPLLPLPEEPQLCPRS----EGPHLSPRPEEPHLSPRPEEPHLSP 763
Query: 2478 QADE 2481
QA+E
Sbjct: 764 QAEE 767
Score = 46.6 bits (109), Expect = 3e-04
Identities = 84/329 (25%), Positives = 115/329 (34%), Gaps = 62/329 (18%)
Query: 2210 PNPLEPGEIREYVPPPVP--------------------LPPGPSTHLAEQS-TGMAAQAP 2248
P P PGE+ +PP VP P P T+ S TG AQ P
Sbjct: 2151 PGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPP 2210
Query: 2249 KMSDKPPADTNQMLSLSKKALAG-TCQRPLLPERPLERTDSRPQPLDKVR-----DLAGS 2302
ML S + AG + P S P P K R +LA
Sbjct: 2211 ------------MLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVP 2258
Query: 2303 GTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPV--TSPSSSPS----VRSQPLERPLGT 2356
+ + PL PP R L K + +SPS P V S LG
Sbjct: 2259 ESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGG 2318
Query: 2357 ADPRL-DKSIGAASPRPQSLEKTSVPTGLR--LPPPDRLLITSSP------KPQTSDRPT 2407
+ + D +PR +E S GLR PPP + L S P +P + P
Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPY 2378
Query: 2408 DKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQ-K 2466
+P + + PPPE + ++L + + P +QS +++ LTPR
Sbjct: 2379 AQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQS-------PLTPRPLS 2431
Query: 2467 ERAASPHQVTPQADEKMPVLESSSWPASK 2495
A P VTP+ P S P S+
Sbjct: 2432 AEAFCPSPVTPRFQSPDPYSRPPSRPQSR 2460
Score = 45.8 bits (107), Expect = 6e-04
Identities = 30/113 (26%), Positives = 49/113 (43%), Gaps = 20/113 (17%)
Query: 1639 ICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRG 1698
+C+ C + ++G L+ C +C YH +C+ SKI + +G
Sbjct: 1379 MCVVCGSFG----RGAEGHLLACSQCSQCYHP--YCV--NSKITKVMLL---------KG 1421
Query: 1699 CRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLN---IDIPEGNWYCNDC 1748
R E + C S+ LL CD C ++H CL+ + +P+G W C C
Sbjct: 1422 WRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWC 1474
Score = 45.4 bits (106), Expect = 7e-04
Identities = 40/145 (27%), Positives = 52/145 (35%), Gaps = 33/145 (22%)
Query: 1593 CFVCKQSGEDVKRCLLPL--CGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPAN 1650
C VC G + LL C + YH CV VM KG+RC CI C A
Sbjct: 1380 CVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCV--ECIVCEVCGQA- 1436
Query: 1651 VSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWC 1710
+ RL+ C C ++YH +CL P P+ G + WC
Sbjct: 1437 --SDPSRLLLCDDCDISYHT--YCLDP------------PLLTVPKGGWK------CKWC 1474
Query: 1711 FVCSEGGSLLCCDSCPAAFHRECLN 1735
C + C + FH E N
Sbjct: 1475 VSCMQ------CGAASPGFHCEWQN 1493
Score = 43.9 bits (102), Expect = 0.002
Identities = 70/293 (23%), Positives = 102/293 (34%), Gaps = 42/293 (14%)
Query: 2209 GPNPLEPGEIREYVP--PPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSK 2266
GP P +PG + + P V + P L Q G+ A+ P++ P Q+ +L
Sbjct: 4169 GPQPPKPGPVLQSGQGLPGVGIMPTVG-QLRAQLQGVLAKNPQLRHLSPQQQQQLQAL-- 4225
Query: 2267 KALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPR 2326
QR L + + +T +P GT++ L + G +
Sbjct: 4226 -----LMQRQLQQSQAVRQTPPYQEP----------GTQTSPL----------QGLLGCQ 4260
Query: 2327 PQLSDKPSPVTSPSSSPSVRSQPLERPLGTADP---RLDKSIGAASPRPQSLEKTSVPTG 2383
PQL P P T P +P P A P +G P P
Sbjct: 4261 PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRP 4320
Query: 2384 LRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTL-VAKEKALRPV 2442
+LP P L T + P T T KP + PPP +V A Q K L P
Sbjct: 4321 SQLPSPSSQLPTEAQLPPTHP-GTPKPQGPTLE--PPPGRVSPAAAQLADTLFSKGLGPW 4377
Query: 2443 D-----QNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSS 2490
D TQ +++LV +D Q AS + + E+ L + S
Sbjct: 4378 DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQS 4430
Score = 32.0 bits (71), Expect = 8.5
Identities = 89/385 (23%), Positives = 125/385 (32%), Gaps = 58/385 (15%)
Query: 2204 EHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPP-ADTNQML 2262
E P P P +P E P P LP P S + A +PP + + L
Sbjct: 856 EKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEEL 915
Query: 2263 SLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAV 2322
LS + L+P PL P PL + A + +S L+ P
Sbjct: 916 PLSPSG-EPSLSPQLMPPDPL------PPPLSPIITAA-----APPALSPLGELEYPFGA 963
Query: 2323 AGPRPQLSDKPSPVTSPSSSPSVR---SQPLERPLGTADPRLDKSIGAASPRPQSLEKTS 2379
G S +P+ SP + P P P +G ASP
Sbjct: 964 KGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILME----- 1018
Query: 2380 VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKAL 2439
LPP L+ S PQ S P+ +L +P P + VV V+ E L
Sbjct: 1019 -----PLPPQCSPLLQHSLVPQNSP-PSQCSPPALPLSVPSPLSPIGKVVG--VSDEAEL 1070
Query: 2440 RPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPA---SKG 2496
++ S+ P + A SP +P D P S PA G
Sbjct: 1071 HEMETEKVSEPEC----------PALEPSATSP-LPSPMGDLSCPA--PSPAPALDDFSG 1117
Query: 2497 LGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKA-----FLYEP 2551
LG E D + G P + P L + +L P A +Y
Sbjct: 1118 LG------EDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPE 1171
Query: 2552 TTQASGRASAGAEQTP--GPLSQSP 2574
Q +G+ S EQ P++ +P
Sbjct: 1172 CKQTAGQGSPCEEQEEPRAPVAPTP 1196
Score = 32.0 bits (71), Expect = 8.5
Identities = 67/280 (23%), Positives = 93/280 (33%), Gaps = 73/280 (26%)
Query: 2207 PCGPNPLEPGE---IREYVPPPVPLPPGPS------THLAEQSTGMAAQAPKMSDK---- 2253
P GP+ GE + PP V PP P +H A Q +G+ + K D
Sbjct: 2593 PLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGM 2652
Query: 2254 ---------PPADTNQMLSLSKKALAGTCQRPLLPE----RPLERTDSRPQPLDKVRDLA 2300
P M LS+ L QR L E + ++R R Q + A
Sbjct: 2653 GSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLR-QEKETAAAAA 2711
Query: 2301 G------------SGTKSQSLVSSQRPL----DRPPAVAGPRPQLSDKPSPVTSPSSSPS 2344
G S + L Q P D+ V P +LS P+ P S PS
Sbjct: 2712 GAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLS---GPILGPGSFPS 2768
Query: 2345 VRSQPLERPLGTADPRL-----------DKSIGAASPRPQSL------------EKTSVP 2381
L RP A P ++ +P P SL ++ +
Sbjct: 2769 --DDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAA 2826
Query: 2382 TGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPP 2421
T +R R S+P P+ + P A +S RLP P
Sbjct: 2827 TSMRFAMSARF--PSTPGPELGRQALGSPLAGISTRLPGP 2864
Score = 32.0 bits (71), Expect = 8.5
Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 2120 ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWE---CPWHQC-DICGKEAASF 2174
+C C G SC + CP VYH C K K + CP H+ C +E +SF
Sbjct: 5091 KCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSF 5149
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 72.4 bits (176), Expect = 6e-12
Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 2/135 (1%)
Query: 1944 VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDK 2003
V + R+ +G GL DI+K V EY+G +I E + + + + YM +D
Sbjct: 4773 VYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQN-RGVYMFRMDN 4831
Query: 2004 DRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL 2063
D +IDA G AR++NH C PNC + + ++ + + I+ G EL ++Y +
Sbjct: 4832 DHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFE 4891
Query: 2064 GN-GKTVCKCGAPNC 2077
+ K C CGA NC
Sbjct: 4892 DDQHKIPCHCGAVNC 4906
Score = 56.2 bits (134), Expect = 4e-07
Identities = 43/133 (32%), Positives = 58/133 (43%), Gaps = 18/133 (13%)
Query: 1546 CQNCEKLGELL---LCEAQCCGAFHLECLGL--TEMPRGKFICNECRTGIHTCFVCKQSG 1600
C C+ G+LL C C +H CL + T + R + C EC+ C CKQSG
Sbjct: 344 CAVCDSPGDLLDQFFCTT-CGQHYHGMCLDIAVTPLKRAGWQCPECKV----CQNCKQSG 398
Query: 1601 EDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRC-SLHICITCHAANPANVSASKGRLM 1659
ED K + C K YH C+Q +V N G++C + ICI C +S
Sbjct: 399 EDSKMLVCDTCDKGYHTFCLQPVMKSVPTN-GWKCKNCRICIEC------GTRSSSQWHH 451
Query: 1660 RCVRCPVAYHAND 1672
C+ C Y D
Sbjct: 452 NCLICDNCYQQQD 464
Score = 51.2 bits (121), Expect = 1e-05
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 28/169 (16%)
Query: 1593 CFVCKQSGEDVKRCLLPL--CGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPAN 1650
C VC G+ + LL CG+ YH CV V+ +KG+RC C C A A
Sbjct: 960 CVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCL--ECTVCEACGKA- 1016
Query: 1651 VSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNS------IICPNHFTPRRGCRNHEH 1704
GRL+ C C ++YH +CL + + + C + G R
Sbjct: 1017 --TDPGRLLLCDDCDISYHT--YCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQ 1072
Query: 1705 VNVSWCFVCS-------------EGGSLLCCDSCPAAFHRECLNIDIPE 1740
N + C C+ E +L C C H C N++ E
Sbjct: 1073 NNYTQCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEE 1121
Score = 47.4 bits (111), Expect = 2e-04
Identities = 31/101 (30%), Positives = 44/101 (43%), Gaps = 18/101 (17%)
Query: 1534 ERGGGAALKENVCQNCEKLGE---LLLCEAQCCGAFHLECLG--LTEMPRGKFICNECRT 1588
+R G + VCQNC++ GE +L+C+ C +H CL + +P + C CR
Sbjct: 379 KRAGWQCPECKVCQNCKQSGEDSKMLVCDT-CDKGYHTFCLQPVMKSVPTNGWKCKNCRI 437
Query: 1589 GI-----------HTCFVCKQSGEDVKRCLLPLCGKFYHEE 1618
I H C +C + L P CGK YH E
Sbjct: 438 CIECGTRSSSQWHHNCLICDNCYQQQDN-LCPFCGKCYHPE 477
Score = 47.4 bits (111), Expect = 2e-04
Identities = 31/120 (25%), Positives = 53/120 (44%), Gaps = 22/120 (18%)
Query: 1633 FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAG-SKILASNSIICPN 1691
F + +C+ C + ++GRL+ C +C YH +C++ +K++ S
Sbjct: 953 FTLNQDMCVVCGSFG----QGAEGRLLACSQCGQCYHP--YCVSIKITKVVLS------- 999
Query: 1692 HFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLN---IDIPEGNWYCNDC 1748
+G R E C ++ G LL CD C ++H CL+ +P+G W C C
Sbjct: 1000 -----KGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWC 1054
Score = 46.6 bits (109), Expect = 3e-04
Identities = 88/360 (24%), Positives = 133/360 (36%), Gaps = 58/360 (16%)
Query: 2224 PPVPLPPGPSTHLAEQSTGMAAQAPKM-SDKPPADTNQMLSLSKKALAGTCQRPLLPERP 2282
PP P P + + + M A + + +PP + + A C RP
Sbjct: 1876 PPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRP 1935
Query: 2283 L---ERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSP 2339
L E T +RP P VRDL S T ++ P +PP PRP ++D+
Sbjct: 1936 LQMNETTANRPSP---VRDLCSSST------TNNDPYAKPPDT--PRPVMTDQFPKSLGL 1984
Query: 2340 SSSPSVRSQPLERPL--GTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSS 2397
S SP V Q + P+ GT+D SPR ++ +P P + S
Sbjct: 1985 SRSPVVSEQTAKGPIAAGTSD-----HFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSG 2039
Query: 2398 PKP-QTSDRP---TDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAA 2453
P P +T +P + P+ S+SQ + LS V RP+D + +++
Sbjct: 2040 PGPFKTPMQPPPSSQDPYGSVSQ----ASRRLS--VDPYERPALTPRPIDNFSHNQSNDP 2093
Query: 2454 LVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPL 2513
+ P E A P + Q + S P S+ P + V
Sbjct: 2094 YSQPPLTPHPAVNESFAHPSRAFSQPG-------TISRPTSQDPYSQPPGTPRPVVDSYS 2146
Query: 2514 QTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQS 2573
Q+SG A + + DP+ SQPP PTT + QTP P +Q+
Sbjct: 2147 QSSGTARS-NTDPY------------SQPPGTP---RPTTV---DPYSQQPQTPRPSTQT 2187
Score = 44.3 bits (103), Expect = 0.002
Identities = 41/168 (24%), Positives = 57/168 (33%), Gaps = 27/168 (16%)
Query: 1593 CFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKG-FRCSLHICITCHAANPANV 1651
C CK G +K C E+C Q Y G F+ HI + C P ++
Sbjct: 285 CAFCKHLGATIKCC---------EEKCTQMYHYPCAAGAGTFQDFSHIFLLC----PEHI 331
Query: 1652 SASKGRLMRCVRCPVAYHAND-----FCLAAGSKILASNSIICPNHFTP--RRGCRNHEH 1704
+ R C V D FC G + + TP R G + E
Sbjct: 332 DQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHY---HGMCLDIAVTPLKRAGWQCPEC 388
Query: 1705 VNVSWCFVCSEGGSLLCCDSCPAAFHRECLN---IDIPEGNWYCNDCK 1749
C E +L CD+C +H CL +P W C +C+
Sbjct: 389 KVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCR 436
Score = 38.5 bits (88), Expect = 0.090
Identities = 71/317 (22%), Positives = 108/317 (34%), Gaps = 44/317 (13%)
Query: 2300 AGSGTKSQSLVSSQRPL----DRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLG 2355
+GS T S + S P + PA + + + +P + +SS V +P P
Sbjct: 1797 SGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPP 1856
Query: 2356 TADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLS 2415
A R+ P SL + PP + + P D +
Sbjct: 1857 PAPSRI--------PIQDSLSQAQTSQ-----PPSPQVFSPGSSNSRPPSPMDPYAKMVG 1903
Query: 2416 QRLPPP------EKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA 2469
PPP + +A V+ RP+ N + NR + V DL + +
Sbjct: 1904 TPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPY 1963
Query: 2470 ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQA 2529
A P D PV+ + +P S GL P E+ G AA + D +
Sbjct: 1964 AKP------PDTPRPVM-TDQFPKSLGLSRSPVVSEQ-------TAKGPIAAGTSDHFTK 2009
Query: 2530 VK---SLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSP-GLVKQAKQ--M 2583
+ Q + + A+ L P SG P P SQ P G V QA +
Sbjct: 2010 PSPRADVFQRQRIPDSYARPLL-TPAPLDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLS 2068
Query: 2584 VGGQQLPALAAKSGQSF 2600
V + PAL + +F
Sbjct: 2069 VDPYERPALTPRPIDNF 2085
>gi|24308089 chromodomain helicase DNA binding protein 5 [Homo
sapiens]
Length = 1954
Score = 70.5 bits (171), Expect = 2e-11
Identities = 37/110 (33%), Positives = 52/110 (47%), Gaps = 19/110 (17%)
Query: 1656 GRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPN------HFTPRR--------GCRN 1701
G ++ C CP AYH CL + CP+ + P+ GC
Sbjct: 353 GEIILCDTCPRAYHL--VCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEE 410
Query: 1702 HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLN---IDIPEGNWYCNDC 1748
E ++ +C VC +GG LLCCD+CP+++H CLN +IP G W C C
Sbjct: 411 EEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRC 460
Score = 54.3 bits (129), Expect = 2e-06
Identities = 44/154 (28%), Positives = 63/154 (40%), Gaps = 30/154 (19%)
Query: 2097 KKFKKKQQGKRRTQGE-ITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLN--LTKRP 2153
KK K++++ KR G+ + +D C C G+++ C CP+ YH CL+ L K P
Sbjct: 321 KKSKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDT--CPRAYHLVCLDPELEKAP 378
Query: 2154 AGKWECP--------WHQCDICGKEAASFCEMCPS---SFCKQHREGMLFISKLDGRLSC 2202
GKW CP W D +E CE FC+ ++G G L C
Sbjct: 379 EGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVCKDG--------GELLC 430
Query: 2203 TE------HDPCGPNPLEPGEIREYVPPPVPLPP 2230
+ H C PL E++ P PP
Sbjct: 431 CDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPP 464
Score = 52.8 bits (125), Expect = 5e-06
Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 1702 HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDI---PEGNWYCNDCK 1749
+E + +C VC +GG ++ CD+CP A+H CL+ ++ PEG W C C+
Sbjct: 338 YETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCE 388
Score = 43.5 bits (101), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 11/77 (14%)
Query: 1516 EEGVEHDPGMPASKKMQGERGGGAALKEN----VCQNCEKLGELLLCEAQCCGAFHLECL 1571
+EG++ +P + E GG +E+ C+ C+ GELL C+A C ++HL CL
Sbjct: 389 KEGIQWEPKDDDDE----EEEGGCEEEEDDHMEFCRVCKDGGELLCCDA-CPSSYHLHCL 443
Query: 1572 G--LTEMPRGKFICNEC 1586
L E+P G+++C C
Sbjct: 444 NPPLPEIPNGEWLCPRC 460
Score = 42.4 bits (98), Expect = 0.006
Identities = 34/126 (26%), Positives = 49/126 (38%), Gaps = 31/126 (24%)
Query: 1529 KKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLG--LTEMPRGKFICNEC 1586
KK + G ++ C+ C++ GE++LC+ C A+HL CL L + P GK+ C C
Sbjct: 329 KKRIDDGDGYETDHQDYCEVCQQGGEIILCDT-CPRAYHLVCLDPELEKAPEGKWSCPHC 387
Query: 1587 -RTGI------------------------HTCFVCKQSGEDVKRCLLPLCGKFYHEECVQ 1621
+ GI C VCK GE C YH C+
Sbjct: 388 EKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVCKDGGE---LLCCDACPSSYHLHCLN 444
Query: 1622 KYPPTV 1627
P +
Sbjct: 445 PPLPEI 450
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 63.5 bits (153), Expect = 3e-09
Identities = 70/319 (21%), Positives = 102/319 (31%), Gaps = 12/319 (3%)
Query: 2212 PLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAG 2271
P EP P P P P+T T AP + +P T + + K A
Sbjct: 244 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 303
Query: 2272 TCQRPLLPERPLERTDSRP-QPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLS 2330
T + P P E + P +P TK + + + P P A P P
Sbjct: 304 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA--PTAPKKPAPTTP 361
Query: 2331 DKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPD 2390
+P+P T +P+ +P P KS + P S PT + P P
Sbjct: 362 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP- 420
Query: 2391 RLLITSSPKPQTSDRP---TDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQ 2447
T P P T P T K A + + P P T T
Sbjct: 421 --TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 478
Query: 2448 SKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKM-PVLESSSWPAS--KGLGHMPRAV 2504
K A + T +K +P + P E++ P P + + P+A
Sbjct: 479 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 538
Query: 2505 EKGCVSDPLQTSGKAAAPS 2523
+P T+ K AP+
Sbjct: 539 APNTPKEPAPTTPKEPAPT 557
Score = 56.2 bits (134), Expect = 4e-07
Identities = 59/288 (20%), Positives = 98/288 (34%), Gaps = 30/288 (10%)
Query: 2203 TEHDPCGPNPLEPGEIREYVPPPV-PLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQM 2261
T +P P EP P P P P+T T + AP + K PA
Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT-TPKKPAPKELA 600
Query: 2262 LSLSKKALAGTCQRPL----------LPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVS 2311
+ +K+ + TC +P P+ P T P P + A + K + +
Sbjct: 601 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTP-KGTAPTTLKEPAPTT 659
Query: 2312 SQRPLDR---PPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAA 2368
++P + P GP SDKP+P T ++P+ +P P ++
Sbjct: 660 PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT 719
Query: 2369 SPRPQSLEKTSVPTGLRLPP----------PDRLLITSSPK----PQTSDRPTDKPHASL 2414
+ + T PT + P P + +SPK P T KP +
Sbjct: 720 TSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 779
Query: 2415 SQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLT 2462
+ + E+ L +T A K + T+ + + +T
Sbjct: 780 TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVT 827
Score = 55.8 bits (133), Expect = 5e-07
Identities = 93/430 (21%), Positives = 146/430 (33%), Gaps = 41/430 (9%)
Query: 2203 TEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQML 2262
T +P EP P P P P+T T AP +P T +
Sbjct: 274 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 333
Query: 2263 SLSKKALAGTCQR---PLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRP 2319
+ + K A T + P P++P T P P ++ A + TK S + + P
Sbjct: 334 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP-KEPAPTTTKEPSPTTPKEP---A 389
Query: 2320 PAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPR--PQSLEK 2377
P P + +P+P T+ S+P+ +P P K +P+ + K
Sbjct: 390 PTTTKSAPTTTKEPAPTTT-KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 448
Query: 2378 TSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEK 2437
PT + P P T P P T P + + + P K L+ +A
Sbjct: 449 EPAPTTPKEPAP---TTTKKPAPTT---PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT 502
Query: 2438 ALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWP--ASK 2495
+P + +L TP + P TP +E P ++ P +
Sbjct: 503 PEKPAPTTPE---------ELAPTTPEE------PTPTTP--EEPAPTTPKAAAPNTPKE 545
Query: 2496 GLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQ-ARLLSQPPAKAFLYEPTTQ 2554
P+ +P T+ K AP+ A +L + A + PA L TT+
Sbjct: 546 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605
Query: 2555 ASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEE 2614
+ P +P K+ + PA G + +L K PA PT
Sbjct: 606 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE--PAPTTPKGTAPTTL-KEPA--PTTP 660
Query: 2615 KKLVTTEQSP 2624
KK E +P
Sbjct: 661 KKPAPKELAP 670
Score = 44.3 bits (103), Expect = 0.002
Identities = 95/472 (20%), Positives = 154/472 (32%), Gaps = 60/472 (12%)
Query: 2163 QCDICGKEAASFCEMCPS--SFCKQHREGMLFISKLDGRLSCTEHDPCGPNPL--EPGEI 2218
+CD C + + + CP SFC + + D + + T+ P P+ E G
Sbjct: 42 ECD-CDAQCKKYDKCCPDYESFCAEVK---------DNKKNRTKKKPTPKPPVVDEAGSG 91
Query: 2219 REYVPPPVPLPPGPSTHLAEQSTGMAAQA-----PKMSDKPPADTNQMLSLSKKALAGTC 2273
+ V P +T + ST P+ S P +DT++ SL+
Sbjct: 92 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 151
Query: 2274 QRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKP 2333
+ TD + + + T ++ L + + L +P P+ + + K
Sbjct: 152 TKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT----PKAETTTKG 207
Query: 2334 SPVTSPSS-SPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRL 2392
+T+P +P+ +P P KS P S PT + P P
Sbjct: 208 PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP--- 264
Query: 2393 LITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRA 2452
T P P T P A + + P P SA KE A T K
Sbjct: 265 TTTKEPAPTTPKEP-----APTTTKEPAPTTTKSA---PTTPKEPA-----PTTPKKPAP 311
Query: 2453 ALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPAS--KGLGHMPRAVEKGCVS 2510
+ TP++ +P + P E P P + K P+
Sbjct: 312 TTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 370
Query: 2511 DPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPL 2570
+P T+ K +P+ A + A ++ PA PTT S + P
Sbjct: 371 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA------PTTTKSAPTT--------PK 416
Query: 2571 SQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQ 2622
SP K+ + P K + K PA +E TT++
Sbjct: 417 EPSPTTTKEPAPTTPKEPAPTTPKKPAP---TTPKEPAPTTPKEPAPTTTKK 465
Score = 33.9 bits (76), Expect = 2.2
Identities = 42/224 (18%), Positives = 81/224 (36%), Gaps = 14/224 (6%)
Query: 2211 NPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQA-PKMSDKPPADTNQMLSLSKKAL 2269
+P EPG P P +T +++T + P+ + P T + + ++K
Sbjct: 758 SPKEPGV--PTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 815
Query: 2270 AGTCQRPLLPERPLERTDSRPQPLD--KVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRP 2327
D+ P + K LA T ++ +++ +++P A P+
Sbjct: 816 ESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD 875
Query: 2328 QLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLP 2387
+ ++ + P +P PR+ K +P P+ + T L
Sbjct: 876 RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKP--KTTPTPRKMTSTMP----ELN 929
Query: 2388 PPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQT 2431
P R+ + QT+ RP P++ L + P E A +T
Sbjct: 930 PTSRI---AEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGET 970
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 63.5 bits (153), Expect = 3e-09
Identities = 70/319 (21%), Positives = 102/319 (31%), Gaps = 12/319 (3%)
Query: 2212 PLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAG 2271
P EP P P P P+T T AP + +P T + + K A
Sbjct: 285 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 344
Query: 2272 TCQRPLLPERPLERTDSRP-QPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLS 2330
T + P P E + P +P TK + + + P P A P P
Sbjct: 345 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA--PTAPKKPAPTTP 402
Query: 2331 DKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPD 2390
+P+P T +P+ +P P KS + P S PT + P P
Sbjct: 403 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP- 461
Query: 2391 RLLITSSPKPQTSDRP---TDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQ 2447
T P P T P T K A + + P P T T
Sbjct: 462 --TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 519
Query: 2448 SKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKM-PVLESSSWPAS--KGLGHMPRAV 2504
K A + T +K +P + P E++ P P + + P+A
Sbjct: 520 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 579
Query: 2505 EKGCVSDPLQTSGKAAAPS 2523
+P T+ K AP+
Sbjct: 580 APNTPKEPAPTTPKEPAPT 598
Score = 56.2 bits (134), Expect = 4e-07
Identities = 59/288 (20%), Positives = 98/288 (34%), Gaps = 30/288 (10%)
Query: 2203 TEHDPCGPNPLEPGEIREYVPPPV-PLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQM 2261
T +P P EP P P P P+T T + AP + K PA
Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT-TPKKPAPKELA 641
Query: 2262 LSLSKKALAGTCQRPL----------LPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVS 2311
+ +K+ + TC +P P+ P T P P + A + K + +
Sbjct: 642 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTP-KGTAPTTLKEPAPTT 700
Query: 2312 SQRPLDR---PPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAA 2368
++P + P GP SDKP+P T ++P+ +P P ++
Sbjct: 701 PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT 760
Query: 2369 SPRPQSLEKTSVPTGLRLPP----------PDRLLITSSPK----PQTSDRPTDKPHASL 2414
+ + T PT + P P + +SPK P T KP +
Sbjct: 761 TSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 820
Query: 2415 SQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLT 2462
+ + E+ L +T A K + T+ + + +T
Sbjct: 821 TAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVT 868
Score = 55.8 bits (133), Expect = 5e-07
Identities = 93/430 (21%), Positives = 146/430 (33%), Gaps = 41/430 (9%)
Query: 2203 TEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQML 2262
T +P EP P P P P+T T AP +P T +
Sbjct: 315 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 374
Query: 2263 SLSKKALAGTCQR---PLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRP 2319
+ + K A T + P P++P T P P ++ A + TK S + + P
Sbjct: 375 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP-KEPAPTTTKEPSPTTPKEP---A 430
Query: 2320 PAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPR--PQSLEK 2377
P P + +P+P T+ S+P+ +P P K +P+ + K
Sbjct: 431 PTTTKSAPTTTKEPAPTTT-KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 489
Query: 2378 TSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEK 2437
PT + P P T P P T P + + + P K L+ +A
Sbjct: 490 EPAPTTPKEPAP---TTTKKPAPTT---PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT 543
Query: 2438 ALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWP--ASK 2495
+P + +L TP + P TP +E P ++ P +
Sbjct: 544 PEKPAPTTPE---------ELAPTTPEE------PTPTTP--EEPAPTTPKAAAPNTPKE 586
Query: 2496 GLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQ-ARLLSQPPAKAFLYEPTTQ 2554
P+ +P T+ K AP+ A +L + A + PA L TT+
Sbjct: 587 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646
Query: 2555 ASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEE 2614
+ P +P K+ + PA G + +L K PA PT
Sbjct: 647 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE--PAPTTPKGTAPTTL-KEPA--PTTP 701
Query: 2615 KKLVTTEQSP 2624
KK E +P
Sbjct: 702 KKPAPKELAP 711
Score = 44.3 bits (103), Expect = 0.002
Identities = 95/472 (20%), Positives = 154/472 (32%), Gaps = 60/472 (12%)
Query: 2163 QCDICGKEAASFCEMCPS--SFCKQHREGMLFISKLDGRLSCTEHDPCGPNPL--EPGEI 2218
+CD C + + + CP SFC + + D + + T+ P P+ E G
Sbjct: 83 ECD-CDAQCKKYDKCCPDYESFCAEVK---------DNKKNRTKKKPTPKPPVVDEAGSG 132
Query: 2219 REYVPPPVPLPPGPSTHLAEQSTGMAAQA-----PKMSDKPPADTNQMLSLSKKALAGTC 2273
+ V P +T + ST P+ S P +DT++ SL+
Sbjct: 133 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 192
Query: 2274 QRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKP 2333
+ TD + + + T ++ L + + L +P P+ + + K
Sbjct: 193 TKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT----PKAETTTKG 248
Query: 2334 SPVTSPSS-SPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRL 2392
+T+P +P+ +P P KS P S PT + P P
Sbjct: 249 PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP--- 305
Query: 2393 LITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRA 2452
T P P T P A + + P P SA KE A T K
Sbjct: 306 TTTKEPAPTTPKEP-----APTTTKEPAPTTTKSA---PTTPKEPA-----PTTPKKPAP 352
Query: 2453 ALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPAS--KGLGHMPRAVEKGCVS 2510
+ TP++ +P + P E P P + K P+
Sbjct: 353 TTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 411
Query: 2511 DPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPL 2570
+P T+ K +P+ A + A ++ PA PTT S + P
Sbjct: 412 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA------PTTTKSAPTT--------PK 457
Query: 2571 SQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQ 2622
SP K+ + P K + K PA +E TT++
Sbjct: 458 EPSPTTTKEPAPTTPKEPAPTTPKKPAP---TTPKEPAPTTPKEPAPTTTKK 506
Score = 33.9 bits (76), Expect = 2.2
Identities = 42/224 (18%), Positives = 81/224 (36%), Gaps = 14/224 (6%)
Query: 2211 NPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQA-PKMSDKPPADTNQMLSLSKKAL 2269
+P EPG P P +T +++T + P+ + P T + + ++K
Sbjct: 799 SPKEPGV--PTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 856
Query: 2270 AGTCQRPLLPERPLERTDSRPQPLD--KVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRP 2327
D+ P + K LA T ++ +++ +++P A P+
Sbjct: 857 ESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD 916
Query: 2328 QLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLP 2387
+ ++ + P +P PR+ K +P P+ + T L
Sbjct: 917 RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKP--KTTPTPRKMTSTMP----ELN 970
Query: 2388 PPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQT 2431
P R+ + QT+ RP P++ L + P E A +T
Sbjct: 971 PTSRI---AEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGET 1011
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,891,016
Number of Sequences: 37866
Number of extensions: 6432349
Number of successful extensions: 26883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 805
Number of HSP's that attempted gapping in prelim test: 21873
Number of HSP's gapped (non-prelim): 4799
length of query: 2696
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2576
effective length of database: 13,703,598
effective search space: 35300468448
effective search space used: 35300468448
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.