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Search of human proteins with 19923432
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923432 coiled-coil domain containing 113 isoform 1 [Homo
sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923432 coiled-coil domain containing 113 isoform 1 [Homo sa... 726 0.0
gi|214830928 coiled-coil domain containing 113 isoform 2 [Homo s... 573 e-163
gi|23503317 coiled-coil domain containing 96 [Homo sapiens] 79 9e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 2e-10
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 60 2e-09
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 58 2e-08
gi|148612801 KIAA1009 protein [Homo sapiens] 53 5e-07
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 52 9e-07
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 52 1e-06
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 52 1e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 51 1e-06
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 51 2e-06
gi|203096856 kinesin family member 7 [Homo sapiens] 51 2e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 50 3e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 50 3e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 50 3e-06
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 50 3e-06
gi|45439370 TAO kinase 1 [Homo sapiens] 50 3e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 50 3e-06
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 50 3e-06
gi|71061468 centromere protein E [Homo sapiens] 50 4e-06
gi|55770834 centromere protein F [Homo sapiens] 49 6e-06
gi|153791839 sodium channel associated protein 1 [Homo sapiens] 49 6e-06
gi|31982906 cingulin-like 1 [Homo sapiens] 49 7e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 49 1e-05
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 49 1e-05
gi|58530840 desmoplakin isoform I [Homo sapiens] 48 1e-05
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 48 1e-05
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 48 1e-05
>gi|19923432 coiled-coil domain containing 113 isoform 1 [Homo
sapiens]
Length = 377
Score = 726 bits (1875), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR 60
MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR
Sbjct: 1 MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR 60
Query: 61 PPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRA 120
PPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRA
Sbjct: 61 PPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRA 120
Query: 121 NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR
Sbjct: 121 NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
Query: 181 RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN
Sbjct: 181 RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
Query: 241 QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA 300
QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA
Sbjct: 241 QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA 300
Query: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN 360
KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN
Sbjct: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN 360
Query: 361 RMKITNEQLQADYLAGK 377
RMKITNEQLQADYLAGK
Sbjct: 361 RMKITNEQLQADYLAGK 377
>gi|214830928 coiled-coil domain containing 113 isoform 2 [Homo
sapiens]
Length = 323
Score = 573 bits (1476), Expect = e-163
Identities = 313/377 (83%), Positives = 317/377 (84%), Gaps = 54/377 (14%)
Query: 1 MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR 60
MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR
Sbjct: 1 MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQR 60
Query: 61 PPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRA 120
PPR L ++ AD
Sbjct: 61 PPR-------------------------------------LSEIKISAAD---------- 73
Query: 121 NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
+ +AIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR
Sbjct: 74 -------YAQAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 126
Query: 181 RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN
Sbjct: 127 RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 186
Query: 241 QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA 300
QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA
Sbjct: 187 QELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA 246
Query: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN 360
KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN
Sbjct: 247 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWN 306
Query: 361 RMKITNEQLQADYLAGK 377
RMKITNEQLQADYLAGK
Sbjct: 307 RMKITNEQLQADYLAGK 323
>gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
Length = 555
Score = 78.6 bits (192), Expect = 9e-15
Identities = 77/295 (26%), Positives = 140/295 (47%), Gaps = 33/295 (11%)
Query: 77 FRGRRRSKSRTGM---DRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQ--HHEA 131
F RR K DRG A +K + + + M ++L+ +A+ DLQ H E
Sbjct: 254 FEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLG-MLEELKKQQAD---DLQWYHQEL 309
Query: 132 --IIEEAEIRWSEVSREVHEFE----KDILKAIS--KKKGSILATQKVMKYIEDMNRRRD 183
+ + + + + V +E F+ + +++A+ + +G A + ++ I+ + +++
Sbjct: 310 GQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKE 369
Query: 184 NMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQEL 243
+RL+N+ LK ++R +E++++ L +DF+QLKIEN F E IE RN+EL
Sbjct: 370 KEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEEL 429
Query: 244 TQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAE 303
+L+ N++QV+ K KLH +D E +K L +IE + + K +
Sbjct: 430 LKLRSKVTNSVQVITHVKEKLH-------FMDMENACKKTQLAEIEAQAALGRDILTKTK 482
Query: 304 AVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSI---RMWERKVEIAEMSLKGH 355
+ LR R Q + + L DLE+ + + R++E SLK H
Sbjct: 483 QAREGLRTD--NIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLE----SLKRH 531
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 64.3 bits (155), Expect = 2e-10
Identities = 88/361 (24%), Positives = 157/361 (43%), Gaps = 50/361 (13%)
Query: 29 LVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPR-LSEIKISAADYAQFRGRRRSKSRT 87
L++E + + ++T E E+ LE ++ + +S ++ + A+ R + K
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 88 GMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAER------DLQHHEAIIEEAEIRWS 141
+ + T+ KL ++ E +K +L H + ER +L H E +E E+
Sbjct: 591 ILHESIKETSS-KLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE---KENELLQK 646
Query: 142 EVSR--------EVHEFEKDILKAISKKKGSILATQKVMKY----IEDMNRRRDNMKEKL 189
+++ E E E L+ ++K L + K + + +E N + D +L
Sbjct: 647 KITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 190 RLKNVSLKVQRKKML-LQLRQKEEVSEALH------------------DVDFQQLKIENA 230
R SLK KM LQL KE SE +V +Q L IEN
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 231 QFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEK 290
+ +T+E N+++ QL+ + LQ L L K +E K + ++ + +E+
Sbjct: 767 RLQKTLENSNKKIQQLE----SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 291 ETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEM 350
ET Q+E+D+ + E NKRLR+Q AE + T + +LEK + +++ I +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQ-AEIKD---TTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 351 S 351
S
Sbjct: 879 S 879
Score = 47.8 bits (112), Expect = 2e-05
Identities = 68/370 (18%), Positives = 150/370 (40%), Gaps = 31/370 (8%)
Query: 30 VEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGM 89
+E+L N +L+ ET EK +LE ++R + +EIK + + + K +
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Query: 90 DRGVGLTAD----------QKLELVQKEVADMK-----------DDLRHTRANAERDLQH 128
+ +G+ + + ELV++ D+K + L+ + N + +
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 129 HEAI---IEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNM 185
HE + + + E S + ++ K S K S+ ++ + +E N
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989
Query: 186 KEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQ 245
++LR + ++K + + L Q + +E + ++ + + K E T E +
Sbjct: 990 NQQLRQELKTVK-KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 246 LKLSSGN-TLQV-LNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAE 303
+++ N TLQ A K++L + NL +IL + ++++ ++ AK +
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 304 AVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMK 363
N L Q +++ L + E I+ E + + +K H K ++
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK----LE 1164
Query: 364 ITNEQLQADY 373
+ +E+ ++Y
Sbjct: 1165 LLHERQASEY 1174
Score = 42.0 bits (97), Expect = 0.001
Identities = 64/360 (17%), Positives = 147/360 (40%), Gaps = 64/360 (17%)
Query: 24 IQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRS 83
++L ++ + L+ +TE +LE + RL + ++ A+ R
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 84 KSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEV 143
+ ++ V + KLE + D+ +A E + ++ ++E + ++
Sbjct: 311 ELDALREKAVRV---DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 144 ------SREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLK 197
S ++HE EK+ L+ +K + DM RD ++K+ +
Sbjct: 368 EGTRARSDKLHELEKENLQLKAK--------------LHDMEMERDMDRKKIE------E 407
Query: 198 VQRKKMLLQLRQKEEVSEALH--------------------DVDFQQLKIENAQFLETIE 237
+ + M L++ QK+ + E+LH + + ++ +++ L+ +E
Sbjct: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK-LE 466
Query: 238 ARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEE 297
NQ LT+ T+ + SK+ L ++KE + +E +E E +Q ++
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKI-------LKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 298 DRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRK 357
+ ++K L K+ A+ + + +RE + E+ I++ E++ E ++ R+
Sbjct: 520 SLQNCQNLSKDLMKEKAQLE--KTIETLRE-----NSERQIKILEQENEHLNQTVSSLRQ 572
Score = 34.3 bits (77), Expect = 0.19
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 29/169 (17%)
Query: 129 HEAIIEEAE---------IRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKY----I 175
+E++I+E E I+ E +HE + +++ K G++ + K ++ +
Sbjct: 1139 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1198
Query: 176 EDMNRRRDNMKEKLRLKNVS--LKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFL 233
ED R +K+K +L+++ LKV+++KMLL+ + E V+ ++++L EN +
Sbjct: 1199 ED--RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA-----AEYKKLCGENDRLN 1251
Query: 234 ETIEARNQELTQLKLSSGNTLQVLNAYK-------SKLHKAMEIYLNLD 275
T +E L+ N +LN K ++ K E Y LD
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1300
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 88/361 (24%), Positives = 157/361 (43%), Gaps = 50/361 (13%)
Query: 29 LVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPR-LSEIKISAADYAQFRGRRRSKSRT 87
L++E + + ++T E E+ LE ++ + +S ++ + A+ R + K
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 88 GMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAER------DLQHHEAIIEEAEIRWS 141
+ + T+ KL ++ E +K +L H + ER +L H E +E E+
Sbjct: 591 ILHESIKETSS-KLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE---KENELLQK 646
Query: 142 EVSR--------EVHEFEKDILKAISKKKGSILATQKVMKY----IEDMNRRRDNMKEKL 189
+++ E E E L+ ++K L + K + + +E N + D +L
Sbjct: 647 KITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 190 RLKNVSLKVQRKKML-LQLRQKEEVSEALH------------------DVDFQQLKIENA 230
R SLK KM LQL KE SE +V +Q L IEN
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 231 QFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEK 290
+ +T+E N+++ QL+ + LQ L L K +E K + ++ + +E+
Sbjct: 767 RLQKTLENSNKKIQQLE----SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 291 ETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEM 350
ET Q+E+D+ + E NKRLR+Q AE + T + +LEK + +++ I +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQ-AEIKD---TTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 351 S 351
S
Sbjct: 879 S 879
Score = 50.1 bits (118), Expect = 3e-06
Identities = 70/369 (18%), Positives = 150/369 (40%), Gaps = 30/369 (8%)
Query: 30 VEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGM 89
+E+L N +L+ ET EK +LE ++R + +EIK + + + K +
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Query: 90 DRGVGLTAD----------QKLELVQKEVADMK------DDLRHTRANAERDLQHHEAII 133
+ +G+ + + ELV++ D+K +DL + ++ E +
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 134 EEAEIRWSEVSREVHEFEK--DILKAISKK-----KGSILATQKVMKYIEDMNRRRDNMK 186
E E R +H+ + D K + K K S+ ++ + +E N
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 989
Query: 187 EKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQL 246
++LR + ++K + + L Q + +E + ++ + + K E T E + +
Sbjct: 990 QQLRQELKTVK-KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 247 KLSSGN-TLQV-LNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEA 304
++ N TLQ A K++L + NL +IL + ++++ ++ AK +
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 305 VNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKI 364
N L Q +++ L + E I+ E + + +K H K +++
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK----LEL 1164
Query: 365 TNEQLQADY 373
+E+ ++Y
Sbjct: 1165 LHERQASEY 1173
Score = 42.0 bits (97), Expect = 0.001
Identities = 64/360 (17%), Positives = 147/360 (40%), Gaps = 64/360 (17%)
Query: 24 IQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRS 83
++L ++ + L+ +TE +LE + RL + ++ A+ R
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 84 KSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEV 143
+ ++ V + KLE + D+ +A E + ++ ++E + ++
Sbjct: 311 ELDALREKAVRV---DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 144 ------SREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLK 197
S ++HE EK+ L+ +K + DM RD ++K+ +
Sbjct: 368 EGTRARSDKLHELEKENLQLKAK--------------LHDMEMERDMDRKKIE------E 407
Query: 198 VQRKKMLLQLRQKEEVSEALH--------------------DVDFQQLKIENAQFLETIE 237
+ + M L++ QK+ + E+LH + + ++ +++ L+ +E
Sbjct: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK-LE 466
Query: 238 ARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEE 297
NQ LT+ T+ + SK+ L ++KE + +E +E E +Q ++
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKI-------LKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 298 DRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRK 357
+ ++K L K+ A+ + + +RE + E+ I++ E++ E ++ R+
Sbjct: 520 SLQNCQNLSKDLMKEKAQLE--KTIETLRE-----NSERQIKILEQENEHLNQTVSSLRQ 572
Score = 34.3 bits (77), Expect = 0.19
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 29/169 (17%)
Query: 129 HEAIIEEAE---------IRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKY----I 175
+E++I+E E I+ E +HE + +++ K G++ + K ++ +
Sbjct: 1138 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1197
Query: 176 EDMNRRRDNMKEKLRLKNVS--LKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFL 233
ED R +K+K +L+++ LKV+++KMLL+ + E V+ ++++L EN +
Sbjct: 1198 ED--RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA-----AEYKKLCGENDRLN 1250
Query: 234 ETIEARNQELTQLKLSSGNTLQVLNAYK-------SKLHKAMEIYLNLD 275
T +E L+ N +LN K ++ K E Y LD
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1299
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 60.5 bits (145), Expect = 2e-09
Identities = 76/371 (20%), Positives = 165/371 (44%), Gaps = 42/371 (11%)
Query: 29 LVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTG 88
L + S N L + E+ EK + ++ ++++IK+ A ++K
Sbjct: 932 LAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAV---------KAKKELD 982
Query: 89 MDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIE-EAEIRWSEVSRE- 146
R T ++LE ++ E + +R AE + ++E E + +V +E
Sbjct: 983 SSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE---SYKNLLLEYEKQSEQLDVEKER 1039
Query: 147 VHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVS-LKVQRKKMLL 205
+ FE I + + S L + + ED+ R + ++ +L V L+VQR K ++
Sbjct: 1040 ANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMV 1099
Query: 206 -------QLRQKEEVSEALHDV-DFQQLKIE----------NAQFLETIEARNQELTQLK 247
+L++++++ E V + ++L+++ Q LE ++ Q+ T +
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
Query: 248 LSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETL-------QVEEDRA 300
+ + +++ KL +L++EI ++K+ E +++E Q EE
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT 1219
Query: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWE-RKVEIAEMSLKGHRKAW 359
K + + + +K+LA+ + + + + L +LE S + E K+++AE++ + H K
Sbjct: 1220 KIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKH-KIH 1278
Query: 360 NRMKITNEQLQ 370
+K + EQ Q
Sbjct: 1279 EHLKTSAEQHQ 1289
Score = 46.2 bits (108), Expect = 5e-05
Identities = 61/292 (20%), Positives = 124/292 (42%), Gaps = 20/292 (6%)
Query: 99 QKLELVQKEVADMKDDLRHTR-ANAERDLQHHEAIIEEAEIRWSEVSREVH-EFEKDILK 156
++LE +Q E ++ DL + AN + L++ +I+ E+ + E+H E EK +K
Sbjct: 845 KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Query: 157 AISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKN---VSLKVQRKKMLLQLRQKEEV 213
K +L +++ ++ +D++ + +KN S+K +K+ ++ +E
Sbjct: 905 EHENLK-PLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK 963
Query: 214 SEALHDVDFQQLKI---------ENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
E ++ + +K E E +E+ E QL S + +Q +YK+ L
Sbjct: 964 EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLL 1023
Query: 265 HKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTY 324
+ + LD E +IE T Q+ + E +N LA Q
Sbjct: 1024 LEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAK 1083
Query: 325 VREKILNADLEKSIRMWERKVEI----AEMSLKGHRKAWNRMKITNEQLQAD 372
+ E + +++++ M ++++E E +K H N ++ QLQ +
Sbjct: 1084 LLE-VQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKE 1134
Score = 39.3 bits (90), Expect = 0.006
Identities = 50/216 (23%), Positives = 99/216 (45%), Gaps = 14/216 (6%)
Query: 104 VQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKG 163
+QK+ ++LR +NA +D Q +++E V+ +V E D LK + +
Sbjct: 291 IQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE-DTLKELESQH- 348
Query: 164 SILATQKVMKYIEDMNRRRD----NMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHD 219
SIL + + Y+ ++ + + ++K++ + L+ + ++LL ++ V E L
Sbjct: 349 SILKDE--VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKS 406
Query: 220 VDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEIL 279
+L N QF T+E N+E+ LK + LN ++ L + + L L EI
Sbjct: 407 ----ELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN--ETFLSDSEKEKLTLMFEIQ 460
Query: 280 LRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAE 315
KE E +++E + + + + L+ +L E
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 496
Score = 37.0 bits (84), Expect = 0.029
Identities = 72/362 (19%), Positives = 146/362 (40%), Gaps = 41/362 (11%)
Query: 14 HEGSELELPVIQLCGLVEELSYVNSALKTETEMFEK---YYAKLEPRDQRPPRLSEIKIS 70
HE +LE + +L EE V LK+E K Y + R+ + + K
Sbjct: 378 HEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEI 437
Query: 71 AADYAQFRGRRRSKSRTGMDRGVGLTAD-QKLELVQKEVADMKDDLRHTRANAERDL-QH 128
+ F + T M GL + L+ ++E + LR + +L +
Sbjct: 438 SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGES 497
Query: 129 HEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEK 188
I +E E + + +VHE ++ + A ++K + ++ E + +++ + E
Sbjct: 498 AGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE- 556
Query: 189 LRLKNVSLKVQRKK--MLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQEL--- 243
L+N +Q K LL L Q++ + + L + L E F+ ++ ++E+
Sbjct: 557 --LENTIKNLQEKNGVYLLSLSQRDTMLKEL-EGKINSLTEEKDDFINKLKNSHEEMDNF 613
Query: 244 -------TQLKLSSGNTLQVLNAYKSKL-HKAMEIYLNLDKEILLRKELLEKIEKETLQV 295
+L L G ++ Y S+L K E+ L++ + + + +K+EK +Q+
Sbjct: 614 HKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQM 673
Query: 296 E-----------------EDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSI 338
+ E+ K + K+L + L F + + ++E I LEK +
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI--TQLEKKL 731
Query: 339 RM 340
++
Sbjct: 732 QL 733
Score = 33.1 bits (74), Expect = 0.42
Identities = 35/181 (19%), Positives = 82/181 (45%), Gaps = 32/181 (17%)
Query: 175 IEDMNRRRDNMKEKLR-----LKNVSLKVQRK-KMLLQLRQKEE---------------- 212
I + +D+ KL+ + N K +R+ +++L+L +K E
Sbjct: 589 INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNEL 648
Query: 213 ---VSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSS-GNTLQVLNAYKSKLHKAM 268
+ E L + D K+E + + ++E+ ++ S L++ K +L + +
Sbjct: 649 TGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDL 708
Query: 269 EIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAE--FRAPQVMTYVR 326
E++L+ ++++L++ + + +K L VEE + +NK L + + F Q+ +++
Sbjct: 709 EVFLSQKEDVILKEHITQLEKKLQLMVEEQ----DNLNKLLENEQVQKLFVKTQLYGFLK 764
Query: 327 E 327
E
Sbjct: 765 E 765
Score = 33.1 bits (74), Expect = 0.42
Identities = 38/177 (21%), Positives = 80/177 (45%), Gaps = 21/177 (11%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
Q+LELV+K D + T N E + +E +++E + + + ++ + E++I I
Sbjct: 1143 QELELVKK------DAQQTTLMNME--IADYERLMKELNQKLTNKNNKIEDLEQEI--KI 1192
Query: 159 SKKKGSIL-----ATQKVMKYIEDMNRRRDNMKEKLRLKNVSLK-VQRKKMLLQLRQKEE 212
K+K L + Q ++ E+ N + + K + + K + ++LQ K E
Sbjct: 1193 QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGE 1252
Query: 213 VSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAME 269
+ + QQ+++ Q E +++ LK S+ + L+AY+ ++ E
Sbjct: 1253 L-----EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
Score = 31.6 bits (70), Expect = 1.2
Identities = 56/266 (21%), Positives = 116/266 (43%), Gaps = 32/266 (12%)
Query: 106 KEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSI 165
KE+ ++K++L R+ D + + +EEA E+S ++ +F+ +
Sbjct: 129 KEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQL-KFQNN------------ 175
Query: 166 LATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQL 225
+ V K E++ + R +E++ L +Q K++ +K+E L ++ +
Sbjct: 176 -SEDNVKKLQEEIEKIRPGFEEQI------LYLQ-KQLDATTDEKKETVTQLQNI----I 223
Query: 226 KIENAQFLETIEARNQELTQLKLSSGNTLQVLNAY---KSKLHKAMEIYLNLDKEILLRK 282
+ + + + I + +EL QLK ++ L +K H+A LN KE L+++
Sbjct: 224 EANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQ 283
Query: 283 -ELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMW 341
E EK ++ + E + + N Q+ Q T+V E+++N + K +
Sbjct: 284 CEASEKNIQKKYECELENLRKATSNANQDNQICSILL-QENTFV-EQVVNEKV-KHLEDT 340
Query: 342 ERKVEIAEMSLKGHRKAWNRMKITNE 367
+++E LK N +K+ E
Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLE 366
Score = 30.4 bits (67), Expect = 2.7
Identities = 46/233 (19%), Positives = 102/233 (43%), Gaps = 25/233 (10%)
Query: 18 ELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQF 77
++E+ IQL + E ++ LKT E ++ L QR L E + AA Q
Sbjct: 1259 QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR---TLSAYQQRVTALQE-ECRAAKAEQA 1314
Query: 78 RGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAE 137
+S V L + + Q E A+++ +H E +I++ +
Sbjct: 1315 TVTSEFESYKVRVHNV-LKQQKNKSMSQAET-----------EGAKQEREHLEMLIDQLK 1362
Query: 138 IRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKL---RLKNV 194
I+ + S+ + L+ + + ++L ++ K +++ + ++EKL + +N+
Sbjct: 1363 IKLQD-SQNNLQINVSELQTLQSEHDTLL--ERHNKMLQETVSKEAELREKLCSIQSENM 1419
Query: 195 SLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLK 247
+K + + + QL + EV L + Q++ + +T+E Q+L++++
Sbjct: 1420 MMKSEHTQTVSQLTSQNEV---LRNSFRDQVRHLQEEHRKTVETLQQQLSKME 1469
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 57.8 bits (138), Expect = 2e-08
Identities = 67/315 (21%), Positives = 137/315 (43%), Gaps = 52/315 (16%)
Query: 89 MDRGVGLTADQKLEL-----VQKEVADMKDDL-------RHTRANAERDLQHHEAIIEEA 136
+++G GL+ DQ + ++EV +D L R + A Q E EEA
Sbjct: 134 VEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEA 193
Query: 137 EIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIE-DMNRRRDNMK--------E 187
E S+ +E+ + + + + KK+ +K +K I+ DM+ R+ +K
Sbjct: 194 EHAISQFQQEIQQRQNEASREFRKKE----KLEKELKQIQADMDSRQTEIKALQQYVQKS 249
Query: 188 KLRLKNVSLKVQRKKMLLQLRQKE-----------EVSEALHDVDFQQLKIENAQFLETI 236
K L+ + +++ +K+L + KE + H + +QL EN Q +
Sbjct: 250 KEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALEL 309
Query: 237 EARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLE-KIEKETLQV 295
+A+ +E+ Q++L G LN + ++HK + + E+ KE L+ +I +V
Sbjct: 310 KAKEEEVHQMRLDIGK----LNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREV 365
Query: 296 EEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGH 355
E + +AE K + + L E ILN ++ K++ +++ ++ ++ +
Sbjct: 366 EASKKQAELDRKAMDELLRE-----------RDILNKNMLKAVNATQKQTDLVKLHEQAK 414
Query: 356 RKAWNRMKITNEQLQ 370
R ++ ++ Q
Sbjct: 415 RNLEGEIQNYKDEAQ 429
Score = 45.1 bits (105), Expect = 1e-04
Identities = 66/322 (20%), Positives = 143/322 (44%), Gaps = 40/322 (12%)
Query: 30 VEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGR--RRSKSRT 87
+E+ N+ L+ E E +L +Q+ + E+K + Q R + +K R
Sbjct: 274 LEQFQMRNAKLQQENEQHSLVCEQLSQENQQ--KALELKAKEEEVHQMRLDIGKLNKIRE 331
Query: 88 GMDRGVGLTADQKLELVQ------KEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWS 141
+ + + T DQK E+ Q ++ ++ ++ ++ AE D + + ++ E +I
Sbjct: 332 QIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNK 391
Query: 142 EVSREVHEFEK--DILKAISKKKGSILA--------TQKVMKYIEDMNRRRD-------N 184
+ + V+ +K D++K + K ++ QK K I + + RD +
Sbjct: 392 NMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASD 451
Query: 185 MKEKLRLKNVSLKVQ-------RKKML---LQLRQKEEVSEALH-DVDFQQLKIENAQFL 233
+ +K+ + +KV+ RKK+ ++L+Q++ + EA+ D + + AQ
Sbjct: 452 LTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQ-- 509
Query: 234 ETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETL 293
+ I ++L + + ++A +S L K ++KE K L+K+ ++ L
Sbjct: 510 DEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQAL 569
Query: 294 QVEEDRAKAEAVNKRLRKQLAE 315
+ + K EA ++L + +AE
Sbjct: 570 ETKHFIEKQEAEERKLLRIIAE 591
Score = 31.6 bits (70), Expect = 1.2
Identities = 49/218 (22%), Positives = 90/218 (41%), Gaps = 31/218 (14%)
Query: 105 QKEVADMKDDLR---HTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKA-ISK 160
Q E+ DMK L+ H + D+ E+ + + + + +E K+ LKA + K
Sbjct: 509 QDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKE-----KETLKAELQK 563
Query: 161 KKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDV 220
+ L T+ ++ E E+ +L + + ++ LRQK+E+ + + +
Sbjct: 564 LRQQALETKHFIEKQE---------AEERKLLRIIAEADGER----LRQKKELDQVISER 610
Query: 221 DFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILL 280
D I +Q + RN EL L VLN +S+ ++ +E L EI
Sbjct: 611 D-----ILGSQLVR----RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKK 661
Query: 281 RKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRA 318
+ + + VEE R + + + L K+ RA
Sbjct: 662 LRREKGILARSMANVEELRQEFFHMQRELLKERTRCRA 699
>gi|148612801 KIAA1009 protein [Homo sapiens]
Length = 1403
Score = 52.8 bits (125), Expect = 5e-07
Identities = 56/256 (21%), Positives = 124/256 (48%), Gaps = 21/256 (8%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
+KL+ +QKE+ + + L+ + ER + + E+ + + +E + + +
Sbjct: 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKE----NQSLFSEV 756
Query: 159 SKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALH 218
+ K + ++ + + +ED R+ L + + ++ +L +++ ++ +AL
Sbjct: 757 ASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQAL- 815
Query: 219 DVDFQQLKIENAQFLETIE-ARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKE 277
+VDF+++K E Q + I ++L ++K+ Q ++ + +L E LDK+
Sbjct: 816 EVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKD 875
Query: 278 ILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKS 337
L +E E+IEK L++E + KAE+ N +R+++ +++K +A K
Sbjct: 876 ALRLREANEEIEKLKLEIE--KLKAESGNPSIRQKIR----------LKDKAADA---KK 920
Query: 338 IRMWERKVEIAEMSLK 353
I+ ER+V+ E LK
Sbjct: 921 IQDLERQVKEMEGILK 936
Score = 30.8 bits (68), Expect = 2.1
Identities = 23/112 (20%), Positives = 55/112 (49%), Gaps = 19/112 (16%)
Query: 95 LTADQKLELVQKEVADMKDDLRHTRANAERDLQHH---EAIIEEAEIRWSEVSREVHEFE 151
+ ++ + E++QKE+ + ++LR + N +++H E I++ E+R ++ +E+ +
Sbjct: 1278 VVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQI- 1336
Query: 152 KDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKM 203
I T +V++ + N+ + K +LKN L+ R ++
Sbjct: 1337 -------------IQQTHQVVE--TEQNKEVEKWKRLAQLKNRELEKFRTEL 1373
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 52.0 bits (123), Expect = 9e-07
Identities = 60/286 (20%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 98 DQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKA 157
++KL+L QK AD++ L E + + E E ++ ++V +D
Sbjct: 270 EEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVI 329
Query: 158 ISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEAL 217
K+ I +K+ E +N EK +L N +++++K LQ + E + E L
Sbjct: 330 RETKEDQIAELKKIC---EQSTESLNNDWEK-KLHNAVAEMEQEKFDLQKQHTENIQELL 385
Query: 218 HDVDFQQLKIENAQFLET---------IEARNQELTQLKLSSGNTLQVLNAYKSKLHKAM 268
D + + K+E+ +T +EAR Q+LT +S Q L K++L +
Sbjct: 386 EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
Query: 269 EIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREK 328
+I + +E+ R+ L K EK+ L V + + + + + + ++ +
Sbjct: 446 QITCSELQEVKARRNTLHK-EKDHL-VNDYEQNMKLLQTKYDADINLLKQEHALSASKAS 503
Query: 329 ILNADLEKSIRMWERKVEIAEMSLKGH-RKAWNRMKITNEQLQADY 373
+ +LE+++ +++++ +E+ K R N+ ++ L+ Y
Sbjct: 504 SMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIY 549
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 51.6 bits (122), Expect = 1e-06
Identities = 56/255 (21%), Positives = 113/255 (44%), Gaps = 36/255 (14%)
Query: 81 RRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIE-EAEIR 139
R+S+ G G+ + E +Q E+ KD L+ T+ +A++ E E+
Sbjct: 440 RKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETK----------DALLNVEGEL- 488
Query: 140 WSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQ 199
E R+ HE +K K K +A +K+ E++ + ++E+LRL++ K
Sbjct: 489 --EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKS 546
Query: 200 RKKMLLQLRQKE----------EVSEALHDVDF--QQLKIENAQFLETIEARNQELTQLK 247
LLQL+ +E +V + L+ + Q L+I+ +Q +++ + TQ +
Sbjct: 547 AMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQER 606
Query: 248 LSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVE-----EDRAKA 302
L+ L + HK+++ + +L + + E+ EKE +E + A+
Sbjct: 607 QRLTQELEELEEQHQQRHKSLK-----EAHVLAFQTMEEEKEKEQRALENHLQQKHSAEL 661
Query: 303 EAVNKRLRKQLAEFR 317
+++ R+ + FR
Sbjct: 662 QSLKDAHRESMEGFR 676
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 51.6 bits (122), Expect = 1e-06
Identities = 56/255 (21%), Positives = 113/255 (44%), Gaps = 36/255 (14%)
Query: 81 RRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIE-EAEIR 139
R+S+ G G+ + E +Q E+ KD L+ T+ +A++ E E+
Sbjct: 560 RKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETK----------DALLNVEGEL- 608
Query: 140 WSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQ 199
E R+ HE +K K K +A +K+ E++ + ++E+LRL++ K
Sbjct: 609 --EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKS 666
Query: 200 RKKMLLQLRQKE----------EVSEALHDVDF--QQLKIENAQFLETIEARNQELTQLK 247
LLQL+ +E +V + L+ + Q L+I+ +Q +++ + TQ +
Sbjct: 667 AMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQER 726
Query: 248 LSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVE-----EDRAKA 302
L+ L + HK+++ + +L + + E+ EKE +E + A+
Sbjct: 727 QRLTQELEELEEQHQQRHKSLK-----EAHVLAFQTMEEEKEKEQRALENHLQQKHSAEL 781
Query: 303 EAVNKRLRKQLAEFR 317
+++ R+ + FR
Sbjct: 782 QSLKDAHRESMEGFR 796
Score = 29.6 bits (65), Expect = 4.6
Identities = 26/138 (18%), Positives = 64/138 (46%), Gaps = 12/138 (8%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
+ + + KE+ ++ R+ + + ++ HE + + + +V H EK+I++A
Sbjct: 895 ENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRAD 954
Query: 159 SKKKGSIL-----ATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEV 213
K +L A Q ++ +E+ R++ E ++ + + K ML + + + +
Sbjct: 955 FNKTNELLKEINAALQVSLEEMEEKYLMRESKPE-----DIQMITELKAMLTE--RDQII 1007
Query: 214 SEALHDVDFQQLKIENAQ 231
+ + D F QL++ N +
Sbjct: 1008 KKLIEDNKFYQLELVNRE 1025
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 51.2 bits (121), Expect = 1e-06
Identities = 60/318 (18%), Positives = 157/318 (49%), Gaps = 40/318 (12%)
Query: 95 LTADQKLELVQKEVADMKDDLRHTRANAER---DLQHHEAIIEEAEIRWSEVSREVHEFE 151
L+ +QK E ++ ++ ++ D +A+ E+ DLQ + + E+R +E+S+++ E E
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL-EME 777
Query: 152 KDILKAIS---KKKGSILAT--QKVMKYIED---MNRRRDNMKEKLRLKNVSL------- 196
K+I+ + +KK L + QK+ K E+ + + + + ++ ++++ L
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 197 -------KVQRKKMLLQLRQKEE----VSEALHDV--DFQQLKIENAQFLETIEARNQEL 243
K++++ ++ +L ++ VS++L + +F++ + + +E +EL
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 244 T-QLKLSSGNTLQVLNAYKSKLHKAME------IYLN-LDKEILLRKELLEKIEKETLQV 295
QL++ NTL+ K L K E + LN + ++++ + L++ EKE Q+
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 296 EEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGH 355
+ + + + +++ +KQ+ + + +++ L L++ + +++ + +
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 356 RKAWNRMKITNEQLQADY 373
+ + + + T +QLQ+D+
Sbjct: 1018 QNNYEKSQETFKQLQSDF 1035
Score = 43.1 bits (100), Expect = 4e-04
Identities = 42/212 (19%), Positives = 96/212 (45%), Gaps = 16/212 (7%)
Query: 100 KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAIS 159
+L V+ +++ + D L+++++ E++ Q +A I + E E+ ++ ++ LK
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 160 KKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKM------LLQLRQKEEV 213
+ K S+ +K + + ++M+E+L +LK K+ + +L+Q E
Sbjct: 914 ELKKSL---EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
Query: 214 SEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLN 273
+ + +LKI Q E Q+LTQ + ++ ++ K+ E +
Sbjct: 971 KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 274 L-------DKEILLRKELLEKIEKETLQVEED 298
L + E+L ++ L+ +E++ +ED
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Score = 40.8 bits (94), Expect = 0.002
Identities = 80/386 (20%), Positives = 158/386 (40%), Gaps = 52/386 (13%)
Query: 29 LVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRL-SEI-----KISAAD------YAQ 76
L EELS V + + F++ + E ++Q +L SEI K+ + + +
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436
Query: 77 FRGRRRSKSRTGMDRGVGLTADQKLELVQ-----KEVADMKDDLRHTRANAERDLQHHEA 131
+ +R+ S MD+ + AD +L+L + KE +L+H ++ Q +A
Sbjct: 437 LKEQRQLSSEKLMDKEQQV-ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 132 IIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEK--- 188
+ + + E ++ + + I K + QK + I + + R+++ K
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 189 ----------LRLKNVSLKVQRKKMLLQLRQKEE----VSEALHDVDFQQLKIENAQFLE 234
L+ KN +L+ Q ++ +L+ + E E LHD Q++ + A
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD----QVQEQKAH--- 608
Query: 235 TIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQ 294
+ A + L+ S LN K K+ + ++I + E+LL E + ++ LQ
Sbjct: 609 -LRAAQDRVLSLETSVNELNSQLNESKEKVSQ-LDIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 295 VEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILN-ADLEKSIRMW-------ERKVE 346
D A+ +K+ + QV +++K + + LE ++ + E+K E
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 347 IAEMSLKGHRKAWNRMKITNEQLQAD 372
E +K +K + EQ D
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQD 752
Score = 39.3 bits (90), Expect = 0.006
Identities = 62/345 (17%), Positives = 136/345 (39%), Gaps = 39/345 (11%)
Query: 30 VEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRT-- 87
+EE N +K ++FE+ A+L +EI + Y + R R + +
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLA---------TEIADIKSKYDEERSLREAAEQKVT 194
Query: 88 ----GMDRGVGLTADQKLELVQK----EVADMKDDLRHTRA-------NAERDLQHHEAI 132
+++ + D K EL+Q+ +VA +K +L + ER+ + +
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 133 IEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLK 192
++ + +++ + + ++ K + + QK+ + ++ ++ + E L K
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 193 NVSLKVQRKKMLLQLRQKEEVSEALH--DVDFQQLKIENAQFLETIEARNQELTQLKLSS 250
+K + K+ + LH D+D QQL+ + A L ++ +
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ-------SRLSASETSLHRIHVEL 367
Query: 251 GNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLR 310
+ K +L + Y +L E ++ E+ E+ LQ++ + + +
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 311 KQLAEF--RAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLK 353
+QL E R + EK++ D E+ + + K+ E LK
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLM--DKEQQVADLQLKLSRLEEQLK 470
Score = 35.8 bits (81), Expect = 0.065
Identities = 57/275 (20%), Positives = 122/275 (44%), Gaps = 24/275 (8%)
Query: 75 AQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIE 134
+ F GR T D + ++KL L Q+++ ++ + + + +L+ +A +E
Sbjct: 1033 SDFYGRESELLATRQDLK---SVEEKLSLAQEDLISNRNQIGNQNKLIQ-ELKTAKATLE 1088
Query: 135 EAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNV 194
+ + + +E + +DI K S K+ ++ + + IE++ R++ KL N
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NE 1145
Query: 195 SLKVQRKKMLLQLRQKEEVSEALHDVDFQ-QLKIENAQFLETIEARNQEL--TQLKLSSG 251
LK + + + ++ ++ + L + Q K ++ + E RNQ++ Q+K
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 252 NTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRK 311
+ ++KLH ++ +KE+ ++K E K T+Q+ A+N+ L
Sbjct: 1206 ELKKEFIEKEAKLHSEIK-----EKEVGMKKH-EENEAKLTMQI-------TALNENLGT 1252
Query: 312 QLAEFRAPQVMTYVREKILNADLEKSIRMWERKVE 346
E+++ Q EK + DL I + E V+
Sbjct: 1253 VKKEWQSSQRRVSELEKQTD-DLRGEIAVLEATVQ 1286
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 50.8 bits (120), Expect = 2e-06
Identities = 80/371 (21%), Positives = 149/371 (40%), Gaps = 43/371 (11%)
Query: 25 QLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEI-KISAADYAQFRGRRRS 83
Q+ L L S L+ E K A + RL E+ S + + +RRS
Sbjct: 1601 QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660
Query: 84 ------KSRTGM-DRGVGLTADQ-KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEE 135
+SR G+ DR A Q +++ +Q++VAD + + ER L A +EE
Sbjct: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER-LNGALAKVEE 1719
Query: 136 AEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVS 195
+E + R + E +++ + L QK + E R ++E+L +
Sbjct: 1720 SEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACE---HDRQVLQERLDAARQA 1776
Query: 196 LKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIEN----------------AQFLETIEAR 239
L RK+ Q + + + D++ Q+++ E A L T++
Sbjct: 1777 LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL 1836
Query: 240 NQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDR 299
E L+ G+ + L +++ + L L+K+ + + L+K+E+E L+ ED
Sbjct: 1837 QDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDT 1896
Query: 300 AKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAW 359
+ A RL + T ++ A+ ++ I+ E +V + E S H A
Sbjct: 1897 VRLSAEKGRLDR-----------TLTGAELELAEAQRQIQQLEAQVVVLEQS---HSPAQ 1942
Query: 360 NRMKITNEQLQ 370
+ +QL+
Sbjct: 1943 LEVDAQQQQLE 1953
Score = 45.8 bits (107), Expect = 6e-05
Identities = 83/404 (20%), Positives = 168/404 (41%), Gaps = 68/404 (16%)
Query: 31 EELSYVNSALKTETEMFEKYYAKLEPRDQRPPR-----LSEIKISAADYAQFRGRRRSKS 85
EEL L+ E + +LE + + E++ S Q G+R +
Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLA 679
Query: 86 RTGMDRGVGLT-ADQKLELVQKEVADMKDDLRHTRANAER--------DLQHHEAIIEEA 136
+ ++ L+ A + +++Q E A++ + L T+A A R L+ EA ++++
Sbjct: 680 KELVEVREALSRATLQRDMLQAEKAEVAEAL--TKAEAGRVELELSMTKLRAEEASLQDS 737
Query: 137 EIRWSEVSREVHEFEKDILKAISK---KKGSILATQKVMKYIEDMNRRRDNMKEKLRLKN 193
+ S ++ + + + D+ + +++ +K ++ Q+ + + R E+LRL+
Sbjct: 738 LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797
Query: 194 VSLKVQRKKMLLQLRQKEEVSEALHDV------DFQQLKIENAQFLETIEARNQELTQLK 247
+V R+ + LR E+ EAL + QL+ + AQ + R QEL Q +
Sbjct: 798 ---EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
Query: 248 LSSGNTLQVLNAYK------SKLHKAMEIYL--------NLDKE---ILLRKELLE---- 286
+ ++ L +K H + + L L +E + L KE LE
Sbjct: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914
Query: 287 KIEKETLQVEEDRAKAEA-------VNKRLRKQLAEFRAPQVMT---------YVREKIL 330
+++++ Q+E R + EA + L +LA R + T + +K++
Sbjct: 915 EVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLV 974
Query: 331 NADLEKSIRMWERKVEIAEMSLKGHRK---AWNRMKITNEQLQA 371
A+ E + E++ E + R+ AW ++ QLQ+
Sbjct: 975 QAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS 1018
Score = 42.4 bits (98), Expect = 7e-04
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 30/266 (11%)
Query: 98 DQKLELVQKEVADMKDDLRHTRANAERDLQHH-EAIIEEAEIRWSEVSREVHEFEKDILK 156
++ L+ +Q+E +L RA + LQ E ++ E E+S E+ +++
Sbjct: 992 EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE--- 1048
Query: 157 AISKKKGSILATQKVMKYIEDMNRRRDNMKEKLR-----LKNVSLKVQRKKMLLQLRQKE 211
+ +G +LA + + + + + EKL L +SL+++R+K Q RQ++
Sbjct: 1049 ---RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 212 EVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIY 271
+ S + +L+ AQ E A QE+ +L+ + + + S L +A E+
Sbjct: 1106 DRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARD---LGKQRDSCLREAEELR 1160
Query: 272 LNL----DKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVRE 327
L D LR+ELLE +++ + +E R LR+ L E RE
Sbjct: 1161 TQLRLLEDARDGLRRELLE-AQRKLRESQEGREVQRQEAGELRRSLGEGAKE------RE 1213
Query: 328 KILNADLEKSIRMWERKVEIAEMSLK 353
+ ++ E +R +K E +SLK
Sbjct: 1214 ALRRSNEE--LRSAVKKAESERISLK 1237
Score = 36.2 bits (82), Expect = 0.050
Identities = 72/340 (21%), Positives = 140/340 (41%), Gaps = 34/340 (10%)
Query: 15 EGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADY 74
E + L+ + +L L E L+ L E+ + L+ R ++ + + + +
Sbjct: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER 789
Query: 75 AQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDD---LRHTRANAERDLQHHEA 131
+ + +R G++ + + A+Q E +++++ ++ + L+ A R L E
Sbjct: 790 LEELRLEQEVARQGLEGSLRV-AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ 848
Query: 132 IIEEAEIRWSEVSREVHEFEKDIL-KAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLR 190
+E+A E R+V E+ K K+ + LA Q V E R +LR
Sbjct: 849 ELEQAR---REAQRQVEALERAAREKEALAKEHAGLAVQLVAA--EREGRTLSEEATRLR 903
Query: 191 LKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSS 250
L+ +L+ ++ QL Q E E QL+ E L E EL L+
Sbjct: 904 LEKEALEGSLFEVQRQLAQLEARRE--------QLEAEGQALLLAKETLTGELAGLR--- 952
Query: 251 GNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLR 310
Q + A + K +LDKE++ +K + + E + E+ A E + + R
Sbjct: 953 ----QQIIATQEKA--------SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR 1000
Query: 311 KQLAEFRAPQVMTYVREKILNADLEKSI-RMWERKVEIAE 349
++ A +R + + L + E+ + R+ K E++E
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040
>gi|203096856 kinesin family member 7 [Homo sapiens]
Length = 1343
Score = 50.8 bits (120), Expect = 2e-06
Identities = 90/402 (22%), Positives = 165/402 (41%), Gaps = 78/402 (19%)
Query: 40 LKTETEMFEKYYAKLEPRDQRPPRLSE--------IKISAADYAQFRGRRRSKSRTGMDR 91
L+ ETE + A++ R R L +KI + A F+ +RRS S +
Sbjct: 842 LREETEQKRRLEAEMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSV-- 899
Query: 92 GVGLTADQKLELVQKEV-ADMKDDLRHTRANAE--RDLQHHEAIIEEAEIRWSE------ 142
V L QK+E +K + +M+ L+ RA E +L EAI+ + E E
Sbjct: 900 -VSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLES 958
Query: 143 ---------------VSREVHEFEKDIL-KAISKKKGSILATQKVMKYIEDMNRRRDN-M 185
VS + EK++ K+ ++GS + Q++ I+ + + +D+ +
Sbjct: 959 KRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQSQQQIRGEIDSLRQEKDSLL 1018
Query: 186 KEKLRL-----KNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
K++L + + L + ++ L QL + E +A ++++ I Q + A
Sbjct: 1019 KQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAA--IEYKNEAITCRQ--RVLRASA 1074
Query: 241 QELTQLK---------LSSGNTLQVLNAYKSKL-------HKAM----EIYLNLDK---- 276
L+Q + LSS T +L Y K+ H+ E+ + L++
Sbjct: 1075 SLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRL 1134
Query: 277 ----EILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNA 332
E+ L ++ LE + TLQ +E + + ++ R L E A Y +I
Sbjct: 1135 VYWLEVALERQRLEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQY-EARIQAL 1193
Query: 333 DLEKSIRMW---ERKVEIAEMSLKGHRKAWNRMKITNEQLQA 371
+ E MW E K ++ ++ GH + + + +E QA
Sbjct: 1194 EKELGRYMWINQELKQKLGGVNAVGHSRGGEKRSLCSEGRQA 1235
Score = 39.3 bits (90), Expect = 0.006
Identities = 49/230 (21%), Positives = 98/230 (42%), Gaps = 25/230 (10%)
Query: 98 DQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKA 157
+Q+ E V+ E+++ + LR +D R E R V + +
Sbjct: 749 EQEAEQVRAELSEGQRQLRELEGKELQDAGERS--------RLQEFRRRVAAAQSQVQVL 800
Query: 158 ISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKE----EV 213
KK+ AT++++ +R ++ ++L ++++ + QK E+
Sbjct: 801 KEKKQ----ATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQRRLREETEQKRRLEAEM 856
Query: 214 SEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLN 273
S+ H V +LK E Q + I+ Q K SG+ V++ + + + + +L+
Sbjct: 857 SKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLD 916
Query: 274 LDKE-ILLRKELLEKIEKETLQVEEDRAKAEAV--------NKRLRKQLA 314
+ E +L ++ LE++ +E + E AK EA+ +KRLR A
Sbjct: 917 QEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQA 966
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 50.4 bits (119), Expect = 3e-06
Identities = 70/340 (20%), Positives = 145/340 (42%), Gaps = 44/340 (12%)
Query: 40 LKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTAD- 98
+ ET + AK + D P + +A+D + + + T G D
Sbjct: 39 MSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDE 98
Query: 99 -----QKLELVQKEVADMKDDLRHT---RANAERDLQHHEAIIEEAEIRWSEVSREVHE- 149
Q E +++E+ +R + + L + + +++ E ++ +H+
Sbjct: 99 QKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS 158
Query: 150 --FEKDILKAISKKKGSILATQKVM--KYIEDMNRRRDNMKEKL--------RLKNVSLK 197
F ++ +A+S +ATQK +YIE++ + RD + +L LK + K
Sbjct: 159 WKFAGELEQALSA-----VATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 213
Query: 198 VQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVL 257
+Q K L++ E SE +V + K+E A+ L + E L G LQ +
Sbjct: 214 LQEKLQLVE----SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL----GKELQSV 265
Query: 258 NAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFR 317
+A + E++ L+++ EK+ ++ +++E K + +++R+Q + R
Sbjct: 266 SAKLQAQVEENELWNRLNQQ------QEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319
Query: 318 APQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRK 357
+ M + +E+ + E MWE++ +I E+ K H +
Sbjct: 320 RQEEMMWEKEEKMRRQEE---MMWEKEEKIRELEEKMHEQ 356
Score = 37.0 bits (84), Expect = 0.029
Identities = 49/254 (19%), Positives = 117/254 (46%), Gaps = 14/254 (5%)
Query: 100 KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAIS 159
KL L Q+++ D L + LQ A +EE E+ W+ ++++ E + I
Sbjct: 243 KLLLPQQQLQAEADHLGKELQSVSAKLQ---AQVEENEL-WNRLNQQQEEKMWRQEEKIQ 298
Query: 160 KKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHD 219
+++ I ++ ++ E+ RR++ M + K ++ Q + M + + E+ E +H+
Sbjct: 299 EREEKIQEQEEKIREQEEKMRRQEEMMWE---KEEKMRRQEEMMWEKEEKIRELEEKMHE 355
Query: 220 VDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEIL 279
+ + + E Q E I + + Q + + + + K+ + E+ ++++
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Query: 280 LRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIR 339
++E + + E+E + EE + E +++R+Q + R + +E+++ EK
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQE---EKIREQEKKIREQEEKIREQEEMMQEQEEK--- 468
Query: 340 MWERKVEIAEMSLK 353
M E++ ++ E K
Sbjct: 469 MGEQEGKMCEQEAK 482
Score = 36.2 bits (82), Expect = 0.050
Identities = 57/328 (17%), Positives = 139/328 (42%), Gaps = 32/328 (9%)
Query: 14 HEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAAD 73
H G EL+ +L VEE N + + E + K++ R+++ E KI
Sbjct: 257 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE-KI---- 311
Query: 74 YAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAII 133
R + + + ++K+ ++ + + ++ +R E + E I
Sbjct: 312 -------REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR----ELEEKMHEQEKIR 360
Query: 134 EEAEIRWSEVS-REVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNM---KEKL 189
E+ E R E RE + ++ K +++ +K+ + E M + + M +EK+
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 190 RLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFL-----ETIEARNQELT 244
+ ++ Q +KM RQ+E++ E + Q+ KI + + E + + ++
Sbjct: 421 WEQEEEMQEQEEKM---RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 245 QLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVE----EDRA 300
+ + + + + K+ + + +++I ++E++++ E++ + E E
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREK 328
K + +++R+Q + R +V +E+
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQEE 565
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 50.4 bits (119), Expect = 3e-06
Identities = 55/212 (25%), Positives = 100/212 (47%), Gaps = 24/212 (11%)
Query: 169 QKVMKYIEDMNRRRDNMKEKL---RLKNVSLKVQRKKMLLQLRQKE-EVSEALHDVDFQQ 224
+K +YIE++ + RD + +L + N LK + ++ +LR E E SE +V +
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 225 LKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKEL 284
K+E A+FL L Q++ NTLQ + + + E + +E + R+E
Sbjct: 215 RKLERAKFL---------LPQVQT---NTLQEEMWRQEEELREQEKKIRKQEEKMWRQE- 261
Query: 285 LEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNAD---LEKSIRMW 341
E++ ++ ++ E K KRLR+Q E R + ++K+ + E+ +MW
Sbjct: 262 -ERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 342 ERKVEIAEMSLKGHR---KAWNRMKITNEQLQ 370
E++ ++ E K R + W + K EQ Q
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Score = 32.3 bits (72), Expect = 0.72
Identities = 46/247 (18%), Positives = 103/247 (41%), Gaps = 16/247 (6%)
Query: 98 DQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKA 157
DQ E +K M+D + ER + E + E+ E + E + K
Sbjct: 486 DQMWEQEEK----MRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKK 541
Query: 158 ISKKKGSILATQKVMKYIEDMNRRRDNMKEK---LRLKNVSLKVQRKKMLLQLRQKEEVS 214
+++ ++ M+ E M R M+E+ +R + ++ Q +KM Q + E
Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE 601
Query: 215 EALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNL 274
E + + + + + E + + E + QE ++ +Q + K+ + E
Sbjct: 602 EKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ---EQEEKMWEQEEKMREQ 658
Query: 275 DKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADL 334
++++ +E EK++ + ++ E K + +++R+Q + R + + +E+ +
Sbjct: 659 EEKM---REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQE 715
Query: 335 EKSIRMW 341
EK MW
Sbjct: 716 EK---MW 719
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/289 (20%), Positives = 136/289 (47%), Gaps = 20/289 (6%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEV---SREVH------- 148
++L + VA++K +L T+ E L+ ++E E EV + EVH
Sbjct: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211
Query: 149 ---EFEKDILKAISKKKGSI-LATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
+ +++ A+ K+K + + ++ + +ED+ ++ K++ N+ L+ Q+K++L
Sbjct: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLE-QQKQLL 3270
Query: 205 LQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
+ +QK E L+D + + N + +E+ + ++ S+ + + L+A
Sbjct: 3271 NESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMS-STLDRERELHAQLQSS 3329
Query: 265 HKAMEIYLNLDKEILLRKELLEKIEKETLQVEE---DRAKAEAVNKRLRKQLAEFRAPQV 321
+ L E LL KEL +++E++ ++ E + K + + + R+Q+ + R
Sbjct: 3330 DGTGQSRPPLPSEDLL-KELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3388
Query: 322 MTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQ 370
T E+ N + +K + + KVE + L+ R+ ++ + ++LQ
Sbjct: 3389 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3437
Score = 43.1 bits (100), Expect = 4e-04
Identities = 65/330 (19%), Positives = 140/330 (42%), Gaps = 41/330 (12%)
Query: 25 QLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSK 84
QL LVEELS+ ++ + + +KL + + ++K ++ R K
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 85 SRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVS 144
+ KLE+++KE + D + ++ AE + + + E E+S
Sbjct: 589 HEAEV-----TNYKIKLEMLEKEKNAVLDRMAESQ-EAELERLRTQLLFSHEE----ELS 638
Query: 145 REVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
+ + E + I K K ++ K + I+ + E ++ + +L ++ +++
Sbjct: 639 KLKEDLEIEHRINIEKLKDNLGIHYK--QQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
Query: 205 LQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
L++ + +++ ++L + +++ ++ + + IE QE + K L
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE---------------KGTL 741
Query: 265 HKAMEIYLNLDKEILLRKELLEKIEKE-TLQVEEDRAKAEAVNKRL---RKQLAEFRAPQ 320
+ ++ E+ L+ ELLEK KE ++E A+ EA N L +K L +
Sbjct: 742 EQEVQ-------ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 321 VMTYVREKILNADLEKS---IRMWERKVEI 347
E+++ D KS +WE+++EI
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Score = 42.7 bits (99), Expect = 5e-04
Identities = 77/392 (19%), Positives = 162/392 (41%), Gaps = 52/392 (13%)
Query: 4 DESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALK-------TE-TEMFEKYYAKLE 55
D+S S + LE+ +L G E+ +N L+ TE + +++ A ++
Sbjct: 142 DDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK 201
Query: 56 PRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDL 115
RD +L+ A + RR K T M + LT + +Q + + L
Sbjct: 202 QRDGIITQLT---------ANLQQARREKDET-MREFLELTEQSQKLQIQFQQLQASETL 251
Query: 116 RHTRAN--------AERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILA 167
R++ + A++ + H+ +EE + + ++ +F I K K +
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK---VY 308
Query: 168 TQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKI 227
+ K +E+ N+ KE + + + ++ +K L+L+ K ++ L
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL--------- 359
Query: 228 ENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAM----EIYLNLDKEILLRKE 283
+ E I +NQE+ +KL N+ Q ++ + M E+ K+ +
Sbjct: 360 --GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 284 LLEKIEKET-LQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKIL--NADLEKSIRM 340
+++++E+ET ++E+ RA+ + + + Q+ + Q M + E ++E ++R
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 341 WERKVEIAEMSLKGHRKAWNRMKI----TNEQ 368
+ + + E +K A N + I TN Q
Sbjct: 478 YS-NITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Score = 40.4 bits (93), Expect = 0.003
Identities = 50/260 (19%), Positives = 116/260 (44%), Gaps = 45/260 (17%)
Query: 117 HTRANAERDLQHHEAIIEEAEIR-WSEVSREVHEFEKDILKA------ISKKKGSIL--- 166
HTR E + + + +I WS+V+ E E + ++++ I + ++
Sbjct: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNI 1846
Query: 167 ------ATQKVMKYIEDMNRRRDNMK-EKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHD 219
A +K+++ I + + + ++ K + L S + Q+++ L+ +EE+ E LH+
Sbjct: 1847 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFR-QKQEATESLKCQEELRERLHE 1905
Query: 220 VDF--QQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKE 277
+QL +E ++ I+ E T ++ ++ + +I L++E
Sbjct: 1906 ESRAREQLAVELSKAEGVIDGYADEKT--------------LFERQIQEKTDIIDRLEQE 1951
Query: 278 ILLRKELLEKIEKETLQVEEDR-----------AKAEAVNKRLRKQLAEFRAPQVMTYVR 326
+L L+++E E Q++E+R A+A V ++L ++ + ++ +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Query: 327 EKILNADLEKSIRMWERKVE 346
+ + DL+K ++ E VE
Sbjct: 2012 AEKVRDDLQKQVKALEIDVE 2031
Score = 38.5 bits (88), Expect = 0.010
Identities = 51/278 (18%), Positives = 117/278 (42%), Gaps = 30/278 (10%)
Query: 39 ALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTAD 98
+LK + E+ E+ + + R+Q LS+ + YA +T +R + D
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--------EKTLFERQIQEKTD 1943
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
++ +++E+ + L+ A ++ + E + + E +E + ++ K +
Sbjct: 1944 I-IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 159 SKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQK-------- 210
+K +KV ++ + + E+ + + L+ ++ L+ LRQ+
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 211 --------EEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKS 262
E+ + H+ D Q +I+ + + R Q +++ + + Q+ N K
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ--TREVEQLANHLKE 2120
Query: 263 KLHKAMEIYLN---LDKEILLRKELLEKIEKETLQVEE 297
K K E+ L+ L ++I R E +EK+E ++E+
Sbjct: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Score = 33.5 bits (75), Expect = 0.32
Identities = 75/378 (19%), Positives = 157/378 (41%), Gaps = 77/378 (20%)
Query: 25 QLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSK 84
Q+ GL E+S K ET FEK + ++Q +S++K D Q +S+
Sbjct: 666 QIDGLQNEMSQ-----KIETMQFEKDNL-ITKQNQLILEISKLK----DLQQSLVNSKSE 715
Query: 85 SRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVS 144
T ++ +QKE+ ++ + E++ E ++E +++ +
Sbjct: 716 EMT-----------LQINELQKEIEILRQE--------EKEKGTLEQEVQELQLKTELLE 756
Query: 145 REVHEFEKDILKAIS--KKKGSILATQKVMKYIEDMNRRRDNMKEKLRL----------- 191
+++ E E D+ + + + + SIL +K K +EDM + + ++ RL
Sbjct: 757 KQMKEKENDLQEKFAQLEAENSILKDEK--KTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 192 -----KNVSLKVQR----KKMLLQLRQKEE-------VSEALHDVDFQQLKIENAQFLET 235
K + + ++ K+ +QL ++ E +E +V++Q+L+ E A L+
Sbjct: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV 874
Query: 236 IEARNQELTQLKLSSGNTLQVLNAYKSKLH---------KAMEIYLNLDKEILLRK-ELL 285
+ + +L + L+ LN +LH K + DK + E+
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALN---EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMG 931
Query: 286 EKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKV 345
E +EK+T ++ E + L ++L++ + LN ++ KS++ + +V
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV-KSLKQEKEQV 990
Query: 346 EIAEMSLK---GHRKAWN 360
+ L+ H +A N
Sbjct: 991 SLRCRELEIIINHNRAEN 1008
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/289 (20%), Positives = 136/289 (47%), Gaps = 20/289 (6%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEV---SREVH------- 148
++L + VA++K +L T+ E L+ ++E E EV + EVH
Sbjct: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203
Query: 149 ---EFEKDILKAISKKKGSI-LATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
+ +++ A+ K+K + + ++ + +ED+ ++ K++ N+ L+ Q+K++L
Sbjct: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLE-QQKQLL 3262
Query: 205 LQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
+ +QK E L+D + + N + +E+ + ++ S+ + + L+A
Sbjct: 3263 NESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMS-STLDRERELHAQLQSS 3321
Query: 265 HKAMEIYLNLDKEILLRKELLEKIEKETLQVEE---DRAKAEAVNKRLRKQLAEFRAPQV 321
+ L E LL KEL +++E++ ++ E + K + + + R+Q+ + R
Sbjct: 3322 DGTGQSRPPLPSEDLL-KELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380
Query: 322 MTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQ 370
T E+ N + +K + + KVE + L+ R+ ++ + ++LQ
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3429
Score = 43.1 bits (100), Expect = 4e-04
Identities = 65/330 (19%), Positives = 140/330 (42%), Gaps = 41/330 (12%)
Query: 25 QLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSK 84
QL LVEELS+ ++ + + +KL + + ++K ++ R K
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 85 SRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVS 144
+ KLE+++KE + D + ++ AE + + + E E+S
Sbjct: 589 HEAEV-----TNYKIKLEMLEKEKNAVLDRMAESQ-EAELERLRTQLLFSHEE----ELS 638
Query: 145 REVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
+ + E + I K K ++ K + I+ + E ++ + +L ++ +++
Sbjct: 639 KLKEDLEIEHRINIEKLKDNLGIHYK--QQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
Query: 205 LQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
L++ + +++ ++L + +++ ++ + + IE QE + K L
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE---------------KGTL 741
Query: 265 HKAMEIYLNLDKEILLRKELLEKIEKE-TLQVEEDRAKAEAVNKRL---RKQLAEFRAPQ 320
+ ++ E+ L+ ELLEK KE ++E A+ EA N L +K L +
Sbjct: 742 EQEVQ-------ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 321 VMTYVREKILNADLEKS---IRMWERKVEI 347
E+++ D KS +WE+++EI
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
Score = 42.7 bits (99), Expect = 5e-04
Identities = 77/392 (19%), Positives = 162/392 (41%), Gaps = 52/392 (13%)
Query: 4 DESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALK-------TE-TEMFEKYYAKLE 55
D+S S + LE+ +L G E+ +N L+ TE + +++ A ++
Sbjct: 142 DDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK 201
Query: 56 PRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDL 115
RD +L+ A + RR K T M + LT + +Q + + L
Sbjct: 202 QRDGIITQLT---------ANLQQARREKDET-MREFLELTEQSQKLQIQFQQLQASETL 251
Query: 116 RHTRAN--------AERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILA 167
R++ + A++ + H+ +EE + + ++ +F I K K +
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK---VY 308
Query: 168 TQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKI 227
+ K +E+ N+ KE + + + ++ +K L+L+ K ++ L
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL--------- 359
Query: 228 ENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAM----EIYLNLDKEILLRKE 283
+ E I +NQE+ +KL N+ Q ++ + M E+ K+ +
Sbjct: 360 --GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 284 LLEKIEKET-LQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKIL--NADLEKSIRM 340
+++++E+ET ++E+ RA+ + + + Q+ + Q M + E ++E ++R
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 341 WERKVEIAEMSLKGHRKAWNRMKI----TNEQ 368
+ + + E +K A N + I TN Q
Sbjct: 478 YS-NITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Score = 40.4 bits (93), Expect = 0.003
Identities = 50/260 (19%), Positives = 116/260 (44%), Gaps = 45/260 (17%)
Query: 117 HTRANAERDLQHHEAIIEEAEIR-WSEVSREVHEFEKDILKA------ISKKKGSIL--- 166
HTR E + + + +I WS+V+ E E + ++++ I + ++
Sbjct: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNI 1846
Query: 167 ------ATQKVMKYIEDMNRRRDNMK-EKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHD 219
A +K+++ I + + + ++ K + L S + Q+++ L+ +EE+ E LH+
Sbjct: 1847 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFR-QKQEATESLKCQEELRERLHE 1905
Query: 220 VDF--QQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKE 277
+QL +E ++ I+ E T ++ ++ + +I L++E
Sbjct: 1906 ESRAREQLAVELSKAEGVIDGYADEKT--------------LFERQIQEKTDIIDRLEQE 1951
Query: 278 ILLRKELLEKIEKETLQVEEDR-----------AKAEAVNKRLRKQLAEFRAPQVMTYVR 326
+L L+++E E Q++E+R A+A V ++L ++ + ++ +
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Query: 327 EKILNADLEKSIRMWERKVE 346
+ + DL+K ++ E VE
Sbjct: 2012 AEKVRDDLQKQVKALEIDVE 2031
Score = 40.0 bits (92), Expect = 0.003
Identities = 63/333 (18%), Positives = 140/333 (42%), Gaps = 37/333 (11%)
Query: 39 ALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTAD 98
+LK + E+ E+ + + R+Q LS+ + YA +T +R + D
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--------EKTLFERQIQEKTD 1943
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
++ +++E+ + L+ A ++ + E + + E +E + ++ K +
Sbjct: 1944 I-IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 159 SKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQK-------- 210
+K +KV ++ + + E+ + + L+ ++ L+ LRQ+
Sbjct: 2003 KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 211 --------EEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKS 262
E+ + H+ D Q +I+ + + R Q +++ + + Q+ N K
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ--TREVEQLANHLKE 2120
Query: 263 KLHKAMEIYLN---LDKEILLRKELLEKIEKETLQVE-----EDRAKAEAVNKRLRKQL- 313
K K E+ L+ L ++I R E +EK+E ++E EDR AV + L
Sbjct: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLE 2180
Query: 314 AEFRAPQVMTYVREKILNADLEKSIRMWERKVE 346
+ +A + +EK + +LE+ + + ++E
Sbjct: 2181 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELE 2212
Score = 33.5 bits (75), Expect = 0.32
Identities = 75/378 (19%), Positives = 157/378 (41%), Gaps = 77/378 (20%)
Query: 25 QLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSK 84
Q+ GL E+S K ET FEK + ++Q +S++K D Q +S+
Sbjct: 666 QIDGLQNEMSQ-----KIETMQFEKDNL-ITKQNQLILEISKLK----DLQQSLVNSKSE 715
Query: 85 SRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVS 144
T ++ +QKE+ ++ + E++ E ++E +++ +
Sbjct: 716 EMT-----------LQINELQKEIEILRQE--------EKEKGTLEQEVQELQLKTELLE 756
Query: 145 REVHEFEKDILKAIS--KKKGSILATQKVMKYIEDMNRRRDNMKEKLRL----------- 191
+++ E E D+ + + + + SIL +K K +EDM + + ++ RL
Sbjct: 757 KQMKEKENDLQEKFAQLEAENSILKDEK--KTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 192 -----KNVSLKVQR----KKMLLQLRQKEE-------VSEALHDVDFQQLKIENAQFLET 235
K + + ++ K+ +QL ++ E +E +V++Q+L+ E A L+
Sbjct: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV 874
Query: 236 IEARNQELTQLKLSSGNTLQVLNAYKSKLH---------KAMEIYLNLDKEILLRK-ELL 285
+ + +L + L+ LN +LH K + DK + E+
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALN---EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMG 931
Query: 286 EKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKV 345
E +EK+T ++ E + L ++L++ + LN ++ KS++ + +V
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV-KSLKQEKEQV 990
Query: 346 EIAEMSLK---GHRKAWN 360
+ L+ H +A N
Sbjct: 991 SLRCRELEIIINHNRAEN 1008
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/204 (24%), Positives = 94/204 (46%), Gaps = 17/204 (8%)
Query: 126 LQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQ-KVMKYIEDMNRRRDN 184
LQH + + E R E + + + ++ S+ + + ++ K +D + +
Sbjct: 680 LQHQTELTNQLEYN----KRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTR 735
Query: 185 MKEKLR--LKNVSLKVQRKKMLLQLRQKEEVSEAL--HDVDFQQLKIENAQFLETIEARN 240
+ LR L + K + K +L +L++++ A+ D ++ + Q L EA+
Sbjct: 736 QYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQE 795
Query: 241 QELTQLKLSSGNTLQVLNAYKSKLHKAMEI-----YLNLDKEILLRKELLE-KIEKETLQ 294
E LK+ L++LNAY+SK+ E L++ + LR+ LLE KIE+E L
Sbjct: 796 AECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLA 855
Query: 295 VEEDRAKAEAVNKRLRKQLAEFRA 318
++ +R E + L +Q E A
Sbjct: 856 LQNER--TERIRSLLERQAREIEA 877
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 50.1 bits (118), Expect = 3e-06
Identities = 75/354 (21%), Positives = 152/354 (42%), Gaps = 51/354 (14%)
Query: 40 LKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTAD- 98
+ ET + AK + D P + +A+D + + + T G D
Sbjct: 51 MSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDE 110
Query: 99 -----QKLELVQKEVADMKDDLRHT---RANAERDLQHHEAIIEEAEIRWSEVSREVHE- 149
Q E +++E+ +R + + L + + +++ E ++ +H+
Sbjct: 111 QKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS 170
Query: 150 --FEKDILKAISKKKGSILATQKVM--KYIEDMNRRRDNMKEKL--------RLKNVSLK 197
F ++ +A+S +ATQK +YIE++ + RD + +L LK + K
Sbjct: 171 WKFAGELEQALSA-----VATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 225
Query: 198 VQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVL 257
+Q K L++ E SE +V + K+E A+ L + E L G LQ +
Sbjct: 226 LQEKLQLVE----SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL----GKELQSV 277
Query: 258 NAYKSKLHKAMEIYLNLDK---EILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLA 314
+A + E++ L++ E + R+E EKI++ +++E K +++R+Q
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEWEEKIQEQEEKIREQEEKIREQEE 335
Query: 315 EFRAPQVMTYVREKILNA------DLEKSIR-----MWERKVEIAEMSLKGHRK 357
+ R + M + +E+ + + E+ +R MWE++ +I E+ K H +
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/234 (17%), Positives = 106/234 (45%), Gaps = 30/234 (12%)
Query: 123 ERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRR 182
E ++ E I E E + ++HE EK + +++ + ++ ++ E++ R++
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 183 DNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQE 242
+ M E+ +++ KV R++ E +HD + + + E + + + R QE
Sbjct: 482 EKMHEQEKIRKQEEKVWRQE------------EKMHDQEEKIREQEEKMWRQEEKIREQE 529
Query: 243 LTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKA 302
+ + + K+ + E+ ++++ ++E +++ EK Q E+ R +
Sbjct: 530 ------------EKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 303 EAVNK---RLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLK 353
E + + ++R+Q + + +E+++ EK MWE++ ++ E K
Sbjct: 578 EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEK---MWEQEEKMCEQEEK 628
Score = 35.8 bits (81), Expect = 0.065
Identities = 49/233 (21%), Positives = 101/233 (43%), Gaps = 33/233 (14%)
Query: 123 ERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRR 182
E ++ E ++ E E + E+ ++HE EK ++ +K+ Q+ K E R+
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEK--IREQEEKR------QEEEKIREQEKRQE 413
Query: 183 DNMK-----EKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIE 237
K EK+R + ++ Q KKM RQ+E++ E + ++ + + + + +
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMW---RQEEKIHEQEKIREEEKRQEQEEMWRQEEK 470
Query: 238 ARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEE 297
R QE + K K+H+ +I +E + R+E EK+ + ++ E
Sbjct: 471 IREQE-------------EIWRQKEKMHEQEKI--RKQEEKVWRQE--EKMHDQEEKIRE 513
Query: 298 DRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEM 350
K +++R+Q + R + +E+++ EK E+ E +M
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Score = 32.0 bits (71), Expect = 0.94
Identities = 25/145 (17%), Positives = 67/145 (46%), Gaps = 5/145 (3%)
Query: 98 DQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKA 157
++K+ ++++ + ++ +R E ++ E +++E E + E ++ E EK + +
Sbjct: 515 EEKMWRQEEKIREQEEKIREQ----EEKIREQEEMMQEQEEKMGEQEEKMQEQEK-MRRQ 569
Query: 158 ISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEAL 217
K + ++ + I + + +EK+R + ++ Q +KM Q + E E +
Sbjct: 570 EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Query: 218 HDVDFQQLKIENAQFLETIEARNQE 242
+ + + + E + + + R QE
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQE 654
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 50.1 bits (118), Expect = 3e-06
Identities = 70/308 (22%), Positives = 137/308 (44%), Gaps = 47/308 (15%)
Query: 30 VEELSYVNSALKT---ETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSR 86
+EEL V +T E + FEK +L+ +Q + G +++ +
Sbjct: 433 LEELKKVLGEKETLLYENKQFEKIAEELKGTEQ----------------ELIGLLQAREK 476
Query: 87 TGMDRGVGLTADQKLE-LVQKEVADMKDDLRHTRA-NAERDLQHHEAIIEEAEI--RWSE 142
D + LTA E KEV D+K +L + + N E ++ +E E+ S+
Sbjct: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSD 536
Query: 143 VSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKK 202
++ E+ ++DI +KK+ ++++K IE++ ++ +L LK +R +
Sbjct: 537 MTLELKNQQEDINN--NKKQ-----EERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 203 MLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKS 262
+ +L + EE L +Q++ +N +++E ++ N+ L + + L V +
Sbjct: 590 VKCKLDKSEENCNNLR----KQVENKN-KYIEELQQENKALKKKGTAESKQLNVYEIKVN 644
Query: 263 KLH--------KAMEIYLNLDKEI----LLRKELLEKIEKETLQVEEDRAKAEAVNKRLR 310
KL K EI KEI + + LLE++EK + +E + ++KR +
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQ 704
Query: 311 KQLAEFRA 318
++AE A
Sbjct: 705 HKIAEMVA 712
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 49.7 bits (117), Expect = 4e-06
Identities = 52/275 (18%), Positives = 122/275 (44%), Gaps = 27/275 (9%)
Query: 120 ANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILA-TQKVMKYIEDM 178
+N ++DL+H ++ +++ E R H K+ + I K +G + T K+ +D+
Sbjct: 1752 SNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811
Query: 179 NRRRDNMKEKLR-LKN-----VSLKVQRKKMLLQLRQKEEVSEALHD--VDFQQLKIENA 230
++EK++ LK ++LK + ++ + E++ + + D + +L+IEN
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871
Query: 231 QFLETIEARNQELTQLKLSSGNTLQV---LNAYKSKLHKAMEIYLNLDKEI--------L 279
+ + +E+ + N +V L + +L ++++ D EI +
Sbjct: 1872 NLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM 1931
Query: 280 LRKE-------LLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNA 332
L KE L EKI ++T+Q+ + + + L+K++ E + ++ ++ +N
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
Query: 333 DLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNE 367
+K M + K + +L + ++T +
Sbjct: 1992 SHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026
Score = 47.0 bits (110), Expect = 3e-05
Identities = 76/412 (18%), Positives = 176/412 (42%), Gaps = 50/412 (12%)
Query: 4 DESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPR 63
+ ++ +++ E E E +++ V E ++ E FE LE + R
Sbjct: 1611 ENTKEIVAKMKESQEKEYQFLKMTA-VNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
Query: 64 LSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVA---DMKDDLRHTRA 120
L++I + + + R R+ ++ + + DQ E +++ + + +++L+
Sbjct: 1670 LTQILHENLEEMRSVTKERDDLRS-VEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 121 NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
+ L+ H+ I++ SE + E+ +KD+ + K L Q+ ++ +
Sbjct: 1729 H----LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
Query: 181 RRDNMKEKLR----------------LKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQ 224
+ +KLR L+N + K+Q K L+ + + ++ DV+ Q
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT-LKKDVNETQ 1843
Query: 225 LKI-ENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAM---------EIYLNL 274
K+ E Q + I+ ++ L++L++ + N Q L+ ++ M E L L
Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 275 DKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADL 334
+++ L KE L++ + L+++++ A ++K ++ + + R ++ + DL
Sbjct: 1904 ERDQL--KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 335 EKSIRMWERKVE-----------IAEMSLKGHRKAWNRMKITNEQLQADYLA 375
+KS ++K++ + E H+K N M+ +Q +A L+
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI-NEMEQLKKQFEAQNLS 2012
Score = 42.0 bits (97), Expect = 0.001
Identities = 50/236 (21%), Positives = 106/236 (44%), Gaps = 13/236 (5%)
Query: 84 KSRTGMDRGVG-LTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSE 142
KS T + + L +Q+L KEV++ ++ + E+ + E+
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
Query: 143 VSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKK 202
++ + E +++I K+++K++ ++ K +K E + + D +KE +R ++ + K
Sbjct: 1333 LNEKFQESQEEI-KSLTKERDNL----KTIK--EALEVKHDQLKEHIRETLAKIQESQSK 1385
Query: 203 MLLQLRQKEEVSEALHDV-DFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYK 261
L KE+ +E V + +Q K +++ L IE L++ S + ++ + K
Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-IEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 262 SKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFR 317
L + E+ L E KE +++I + L+ EE+ A K + + E R
Sbjct: 1445 DDLQRLQEV---LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 49.3 bits (116), Expect = 6e-06
Identities = 46/190 (24%), Positives = 90/190 (47%), Gaps = 17/190 (8%)
Query: 134 EEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKY--------IEDMNRRRDNM 185
E+AEI+ E S+ E ++ LK +++ ++ Q++MK IE+ ++ R+++
Sbjct: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
Query: 186 KEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQ 245
EKLR + L+ KK L L+Q + E+ H D + ++EN + I NQE
Sbjct: 2304 -EKLRAR---LEADEKKQLCVLQQ---LKESEHHADLLKGRVENLERELEIARTNQE--H 2354
Query: 246 LKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAV 305
L + N+ + K+K+ + L+ +++ + E + E + +E ++ E +
Sbjct: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 306 NKRLRKQLAE 315
N L E
Sbjct: 2415 NSSFENILQE 2424
Score = 48.9 bits (115), Expect = 7e-06
Identities = 69/315 (21%), Positives = 135/315 (42%), Gaps = 67/315 (21%)
Query: 18 ELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQF 77
EL ++L ++ L N++L+ E+ + Y LE +E++++ D F
Sbjct: 2557 ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE---------NELELTKMDKMSF 2607
Query: 78 --RGRRRSKSRTGMDRGVGLTADQ-----------------KLELVQKEVADMKDDLRH- 117
+ + + T + R + A + +L+L+ +E+ KD L+
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Query: 118 TRANAER----DLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMK 173
T N+E D H + + +E ++R E+ E++ + +A K + +L T K +
Sbjct: 2668 TLENSELKKSLDCMHKDQVEKEGKVR-----EEIAEYQLRLHEAEKKHQALLLDTNK--Q 2720
Query: 174 YIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFL 233
Y ++ R EKL K L Q+ ++ L KEE++ +L
Sbjct: 2721 YEVEIQTYR----EKLTSKEECLSSQKLEIDLLKSSKEELNNSL---------------- 2760
Query: 234 ETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKA---MEIYLNLDKEILLRKELLEKIEK 290
+A Q L +LK + + L+ +N K + +A M++ + K++ KE+L+K E
Sbjct: 2761 ---KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQK-EL 2816
Query: 291 ETLQVEEDRAKAEAV 305
LQ +++ K V
Sbjct: 2817 SQLQAAQEKQKTGTV 2831
Score = 43.1 bits (100), Expect = 4e-04
Identities = 87/405 (21%), Positives = 168/405 (41%), Gaps = 60/405 (14%)
Query: 27 CGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSE-IKISAADYAQFRGRRRSKS 85
C L +++ +N + + E A+L D +S+ ++ + + +F R S
Sbjct: 2052 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
Query: 86 ------RTGMDR-GVGLTADQKLEL----VQKEVADMKDDLRHTRANAERDLQ----HHE 130
R G+++ V + AD+K +L KE D L+ N ER+LQ + E
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
Query: 131 AIIEEAE----------IRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
+I +AE + E++R + FE D++ S+K+ Q+ + ++++
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
Query: 181 RRDNMKEKLRLK---NVSLKVQRKKMLLQLR-QKEEVSEALHDV--DFQQLKIENAQFLE 234
+ K L K + +K + K + L+ Q +E++EA+ + D + +K
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 235 TIEARNQ-----ELTQLKLSSGNTLQ--VLNAYKSKLHKAMEI---YLNLDKEILLRKEL 284
IE +Q E + +L + Q VL K H A + NL++E+ + +
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
Query: 285 LE----KIEKETLQVEEDRAKAEAVNKRLR-------------KQLAEFRAPQVMTYVRE 327
E + E +VE +AK E + + LR + L +
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL 2411
Query: 328 KILNADLEKSIRMWER-KVEIAEMSLKGHRKAWNRMKITNEQLQA 371
+I+N+ E ++ E+ KV++ E S ++K NE++ A
Sbjct: 2412 EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456
Score = 42.4 bits (98), Expect = 7e-04
Identities = 63/297 (21%), Positives = 130/297 (43%), Gaps = 43/297 (14%)
Query: 107 EVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKD--ILKAISKKKG- 163
++ +K L + ++ L E + ++I+ +E+ R + E +K+ +LK+ S++K
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR 500
Query: 164 SILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQ 223
+ + +K I+ + N E+++ KN S ++ ML L++K +++ + + +
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS----QETMLRDLQEK--INQQENSLTLE 554
Query: 224 QLKIENAQF-------LETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDK 276
+LK+ A + ++ R + QL T + A S L + Y L +
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 277 EILL-------RKELLEKI--EKETLQ---------VEEDRAKAEAVNKRLRKQLAEFRA 318
E L ++LL ++ EKE LQ ++ + K+ N+R+R E
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR--TLEMDR 672
Query: 319 PQVMTYVREKILNADLEKSIRMWERKV------EIAEMSLKGHRKAWNRMKITNEQL 369
+ +R + N KS+ + +K+ + AE S + H+K M + QL
Sbjct: 673 ENLSVEIR-NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Score = 37.4 bits (85), Expect = 0.022
Identities = 54/268 (20%), Positives = 115/268 (42%), Gaps = 38/268 (14%)
Query: 114 DLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMK 173
+LR+ E LQ HE E+ +V++F++ L+ + K K ++ +KV+
Sbjct: 289 ELRNKINELELRLQGHE----------KEMKGQVNKFQELQLQ-LEKAKVELIEKEKVLN 337
Query: 174 YIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFL 233
D R ++ K +L+ + KK+ L + + +E+ Q++K + +F
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ 397
Query: 234 E-------TIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKEL-- 284
E + + +QE Q+K LQ +H ++ LDK ++++L
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARLTQELQ----QAKNMHNVLQ--AELDKLTSVKQQLEN 451
Query: 285 -LEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWER 343
LE+ +++ + E+ ++ LR+ + E + +L + E+ R
Sbjct: 452 NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK-------ENNLLKSHSEQK----AR 500
Query: 344 KVEIAEMSLKGHRKAWNRMKITNEQLQA 371
+V E LK ++ N+ + E+++A
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Score = 35.8 bits (81), Expect = 0.065
Identities = 62/294 (21%), Positives = 120/294 (40%), Gaps = 16/294 (5%)
Query: 97 ADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRW-SEVSREVHEFEKDIL 155
A K +++++ + +DL R NAE E I+E E + E+SR+ F+
Sbjct: 353 ASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
Query: 156 KAISKKKGSILATQKVMKYIEDMNRRRDNMKE-KLRLKNVSLKVQRKKMLL--QLRQKEE 212
+ I K Q+ + D + K +L+N +L+ ++K+ Q Q +
Sbjct: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLEN-NLEEFKQKLCRAEQAFQASQ 471
Query: 213 VSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLN-------AYKSKLH 265
+ E +++K EN E + +E+ L+ N Q LN K+K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 266 KAMEIYLNLDKEILLRKE--LLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMT 323
+ +L ++I ++ LEK++ +E+ R ++ + K+ + + T
Sbjct: 532 SQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKT 591
Query: 324 YVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQADYLAGK 377
K L + LE + +E E E +L K+ N +T + + + L K
Sbjct: 592 EKESKALLSALELKKKEYEELKE--EKTLFSCWKSENEKLLTQMESEKENLQSK 643
Score = 35.4 bits (80), Expect = 0.085
Identities = 42/207 (20%), Positives = 86/207 (41%), Gaps = 11/207 (5%)
Query: 106 KEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSI 165
+E+ +K ++ AE Q H++ + E R S++ + + + + +S +
Sbjct: 854 EELVQIKGEIEENLMKAE---QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 166 LATQKVMKYIEDMNRRRDNMKEKLRLKNVSLK-VQRKKMLLQLRQKEEVS-EALHDVDFQ 223
Q + +E +K+ L SLK +Q L L +KE S +L+ + +
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970
Query: 224 QLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRK- 282
+L EN E + NQE L S + ++ + + + + Y +K ILL++
Sbjct: 971 ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY-KQEKLILLQRC 1029
Query: 283 ----ELLEKIEKETLQVEEDRAKAEAV 305
E + ++ +E +K E +
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECL 1056
>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
Length = 688
Score = 49.3 bits (116), Expect = 6e-06
Identities = 77/369 (20%), Positives = 154/369 (41%), Gaps = 41/369 (11%)
Query: 30 VEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGM 89
VEEL+ V L+ + + EK R++ R + S+ + R T
Sbjct: 242 VEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIR-----LCVTIQ 296
Query: 90 DRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHE 149
+ T + LE +E+ ++L + R A ++ ++EEA ++ S+ E +
Sbjct: 297 EANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQ 356
Query: 150 FEKDILK---AISK--KKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
E+DI K +S+ + +I ++V + N + + E+L + ++ ++
Sbjct: 357 KEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIE 416
Query: 205 LQLRQKEEVSEALHDV---------DFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQ 255
+++K+ V E L + D+++L+ + +FL + R+++ QL+L+
Sbjct: 417 RVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFL--VSERSKDDLQLRLTRAE--- 471
Query: 256 VLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAE 315
N K + E + I + +LE + V E R K + NK+LRK+
Sbjct: 472 --NRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
Query: 316 FRAPQVMTYVREKILNADLEKSIRMWER--KVEIAEMS-------------LKGHRKAWN 360
R + + K+ + +E + ER +V++ EM L +KA N
Sbjct: 530 LRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAAN 589
Query: 361 RMKITNEQL 369
R K ++L
Sbjct: 590 RWKEETKKL 598
Score = 34.3 bits (77), Expect = 0.19
Identities = 56/285 (19%), Positives = 129/285 (45%), Gaps = 32/285 (11%)
Query: 100 KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIE---EAEIRWSEVSREVHEFEKDILK 156
+L+ QK+V +MK L + ER + +E EA +EV +++ ++ +
Sbjct: 73 QLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Query: 157 AISKKKGSILATQKVMKYIE-------DMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQ 209
+ + LA Q+ + +E +++R +E + + + + +K QL
Sbjct: 133 LQEQLQ---LANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHV-FESQKQKDQLFD 188
Query: 210 KEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAME 269
+++++ LH V + +++ N QFL+T+ ++ + QL+ + L K +L A+
Sbjct: 189 FQQLTKQLH-VTNENMEVTNQQFLKTVTEQSVIIEQLR-------KKLRQAKLELRVAV- 239
Query: 270 IYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYV---- 325
+++ + ++L +++K+ V + EA ++RL++ + + ++ V
Sbjct: 240 --AKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE 297
Query: 326 --REKILNADLEKSIRMWERKV-EIAEMSLKGHRKAWNRMKITNE 367
+ + N LEK R + K E+ + +A N M++ E
Sbjct: 298 ANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
Score = 34.3 bits (77), Expect = 0.19
Identities = 52/223 (23%), Positives = 98/223 (43%), Gaps = 53/223 (23%)
Query: 27 CGLVEE----LSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRR 82
CGLV E L N L+ ETE K + + + +++KIS ++ +F + R
Sbjct: 506 CGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK-------AKVKISTMEH-EFSIKER 557
Query: 83 SKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSE 142
+ ++ +M+D R N+ +L+H A ++A RW E
Sbjct: 558 G--------------------FEVQLREMEDSNR----NSIVELRHLLATQQKAANRWKE 593
Query: 143 VSREVHEFEK----DILKAISKKKGSILATQKVMKYIEDMNRR-RDNMKEKLRLKNVSLK 197
++++ E + ++ +S++K L TQ+++ +E N + +N K L + + +
Sbjct: 594 ETKKLTESAEIRINNLKSELSRQK---LHTQELLSQLEMANEKVAENEKLILEHQEKANR 650
Query: 198 VQRKKMLLQLRQKEE----VSEALHDVDFQQLKIENAQFLETI 236
+QR+ L Q EE S+ L + Q+ K + LE I
Sbjct: 651 LQRR-----LSQAEERAASASQQLSVITVQRRKAASLMNLENI 688
Score = 33.9 bits (76), Expect = 0.25
Identities = 59/301 (19%), Positives = 118/301 (39%), Gaps = 43/301 (14%)
Query: 113 DDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVM 172
+ LR A+ +L+ A +EE ++ ++ + EKD++ A +++ S Q++
Sbjct: 222 EQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
Query: 173 KYIEDMNRR---RDNMKEKLRLKNVSLKVQRKKMLLQLRQKE-----------EVSEALH 218
I+ + R +LR +N L+ Q +++ + + E + L
Sbjct: 282 SSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLE 341
Query: 219 DVDFQ--QLKIENAQFLETIEARNQELTQL--------KLSSGNTLQVLNAYKSKLHKAM 268
+ + Q Q +E Q E IE + +++ K NT + N S+L + +
Sbjct: 342 EANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL 401
Query: 269 EIYL-----------NLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRL---RKQLA 314
+ KE +E LEKI +E E D K E +++R +
Sbjct: 402 SALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKD 461
Query: 315 EFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRK-----AWNRMKITNEQL 369
+ + R K L D + I ++ ++ + L+ R+ + R+K+ E
Sbjct: 462 DLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENK 521
Query: 370 Q 370
Q
Sbjct: 522 Q 522
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 48.9 bits (115), Expect = 7e-06
Identities = 68/334 (20%), Positives = 145/334 (43%), Gaps = 37/334 (11%)
Query: 32 ELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQ------FRGRRRSKS 85
EL+ + ALK E ++ KL ++Q L ++ S + + R +
Sbjct: 759 ELTALKGALKEEVSSHDQEMDKL--KEQYDAELQALRESVEEATKNVEVLASRSNTSEQD 816
Query: 86 RTGMDRGVGLTADQKLEL------VQKEVADMK---DDLRHTRANAERDLQHHEAII--- 133
+ G + V L ++ +L +++ VA ++ +DL+ A A+ L+ +E I
Sbjct: 817 QAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876
Query: 134 EEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKN 193
EEA + + +E + + + +G++ T + K + + + KE+LR
Sbjct: 877 EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK 936
Query: 194 VSLKVQRKKMLLQLRQ-KEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGN 252
++ +R + + + ++E+++ + L+++N Q E E +EL +++
Sbjct: 937 NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQN-QLDEYKEKNRRELAEMQRQLKE 995
Query: 253 TLQVLNAYKSKL------------HKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRA 300
+ L A KS+L + + Y E L +++LLE+ K+ E ++
Sbjct: 996 --KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053
Query: 301 KAEAVNKRLRKQLAEFRAPQVMTYVREKILNADL 334
+ RL KQ+ E + Q+ + E+ N+DL
Sbjct: 1054 HLKDDRSRLVKQM-EDKVSQLEMELEEERNNSDL 1086
Score = 43.9 bits (102), Expect = 2e-04
Identities = 53/250 (21%), Positives = 109/250 (43%), Gaps = 26/250 (10%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
++L+L K ++K++ RAN E H +EE S + + + E E ++ K +
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN----STLQQRLEESEGELRKNL 683
Query: 159 SKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALH 218
+ + ++ I D+ + M ++L S ++ ++ +L Q ++
Sbjct: 684 EELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ------ 737
Query: 219 DVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEI 278
D Q L I + + + R +ELT LK G + ++++ ++ K E Y D E+
Sbjct: 738 --DLQDLLIAKEEQEDLLRKRERELTALK---GALKEEVSSHDQEMDKLKEQY---DAEL 789
Query: 279 LLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKI--LNADLEK 336
+ L E +E+ T VE A N + Q +++ EK+ + +LE+
Sbjct: 790 ---QALRESVEEATKNVE---VLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELER 843
Query: 337 SIRMWERKVE 346
+ +R++E
Sbjct: 844 RVAQLQRQIE 853
Score = 41.6 bits (96), Expect = 0.001
Identities = 69/356 (19%), Positives = 151/356 (42%), Gaps = 29/356 (8%)
Query: 29 LVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTG 88
L EL L T+ ++ KL+ ++ +L +K + G+ K +
Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
Query: 89 MDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVH 148
M V + LEL Q ++ + K+ R A +R L+ E++ + ++ E+
Sbjct: 957 MADIVEASRTSTLEL-QNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMR 1015
Query: 149 EFEKDILKAISKKKGSILATQKVMKYIEDMN---RRRDNMKE-KLRL-KNVSLKVQRKKM 203
E+++ + ++ Q + + ++D+ + ++K+ + RL K + KV + +M
Sbjct: 1016 LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 204 LLQLRQKEE--VSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYK 261
L+ + +SE + Q ++ N E ++ E ++ L N K
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN-----KDLK 1130
Query: 262 SKLHKAMEIYLNLDKEILLRKEL-LEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQ 320
S++ Y + + ++++ E + ++E E DRA + N+RL +++ E
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL---- 1186
Query: 321 VMTYVREKILNAD----LEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQAD 372
VM E + D L ++ +R+VE AE + +R++ + ++LQ +
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI-------DRLESSKKKLQRE 1235
Score = 37.7 bits (86), Expect = 0.017
Identities = 49/259 (18%), Positives = 115/259 (44%), Gaps = 33/259 (12%)
Query: 80 RRRSKSRTGMDRGVGLTA---DQKLELVQKEVADMK---DDLRHTRANAERDLQHHEAII 133
+R+ K +T LTA ++ L+++E+ D + D+ R E+ L+ E +
Sbjct: 990 QRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL 1049
Query: 134 EEAEIRWSEVSREVHEFEKDI----LKAISKKKGSILATQKVMKYIEDMNRRRDNM---- 185
E + SR V + E + ++ ++ S L ++++ + E M + R+ +
Sbjct: 1050 EAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 186 --KEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQEL 243
++ L +SL+ Q K + ++ E + + Q++ A+ + +E+ ++
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDR 1169
Query: 244 TQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKEL-------LEKIEKETLQVE 296
L+LS+ + K E+ + +D E L + L+ ++++ + E
Sbjct: 1170 ANLQLSN----------RRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAE 1219
Query: 297 EDRAKAEAVNKRLRKQLAE 315
E+ + E+ K+L+++L E
Sbjct: 1220 EEIDRLESSKKKLQRELEE 1238
Score = 36.6 bits (83), Expect = 0.038
Identities = 34/127 (26%), Positives = 58/127 (45%), Gaps = 13/127 (10%)
Query: 72 ADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEA 131
A A+ R S+ R DR ++++LE KE+ DD H ++D
Sbjct: 1153 ARIAELEDRLESEER---DRANLQLSNRRLERKVKELVMQVDD-EHLSLTDQKD------ 1202
Query: 132 IIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRL 191
+ +R + R+V E E++I + S KK ++ M E + + ++MK+ LRL
Sbjct: 1203 ---QLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRL 1259
Query: 192 KNVSLKV 198
K + KV
Sbjct: 1260 KKLPSKV 1266
Score = 29.3 bits (64), Expect = 6.1
Identities = 37/190 (19%), Positives = 89/190 (46%), Gaps = 12/190 (6%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAI 158
+++ ++++ ++++L RA A +DL+ + +E ++ + E
Sbjct: 1089 ERISRSREQMEQLRNELLQERA-ARQDLECDKISLERQN---KDLKSRIIHLEGSYR--- 1141
Query: 159 SKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALH 218
S K+G ++ + + +ED + + L+L N L+ + K++++Q+ ++ +L
Sbjct: 1142 SSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV---DDEHLSLT 1198
Query: 219 DVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEI 278
D QL + +E +E+ +L+ SS LQ + +++ ++ LN K+
Sbjct: 1199 D-QKDQLSLRLKAMKRQVEEAEEEIDRLE-SSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256
Query: 279 LLRKELLEKI 288
L K+L K+
Sbjct: 1257 LRLKKLPSKV 1266
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 48.5 bits (114), Expect = 1e-05
Identities = 66/283 (23%), Positives = 136/283 (48%), Gaps = 46/283 (16%)
Query: 98 DQKLELVQKEVADMKDDLRHT--------------RANAERDLQHHEAIIEEAEIRWSEV 143
+Q++E ++ ++ +++D+L+ T +A ERDLQ + E++E + ++
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD---EQSEEKKKQL 1587
Query: 144 SREVHEFEKDILKAISKKKGSILATQKVMKYIEDM-------NRRRDNMKEKLRLKNVSL 196
R+V E E ++ ++ ++ A +K+ ++D+ N+ RD ++LR L
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR----KL 1643
Query: 197 KVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQV 256
+ Q K + +L + + A + Q K EN + L+++EA +L Q +L++ +
Sbjct: 1644 QAQMKDCMREL----DDTRASREEILAQAK-ENEKKLKSMEAEMIQL-QEELAAAERAK- 1696
Query: 257 LNAYKSKLHKAMEIYLNLDKEILL---RKELLEKIEKETLQVEEDRAKAEAVNKRLRKQL 313
A + + A EI + K L ++ L +I + ++EE++ E +N RL+K
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKK-- 1754
Query: 314 AEFRAPQVMTYVR------EKILNADLEKSIRMWERKVEIAEM 350
A + Q+ T + +K NA + + E KV++ EM
Sbjct: 1755 ANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM 1797
Score = 45.1 bits (105), Expect = 1e-04
Identities = 73/337 (21%), Positives = 140/337 (41%), Gaps = 37/337 (10%)
Query: 40 LKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSR--TGMDRGVGLTA 97
LK + + + K++P Q + E+ + + R ++ + T M+
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879
Query: 98 DQKLELVQKEVADMK--DDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDIL 155
+KL+L ++ A+ + + RA Q E I + E R E + +
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAE-- 937
Query: 156 KAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSE 215
KKK Q+ ++ +E+ ++ ++KL+L+ V+ + + KK+ EE
Sbjct: 938 ----KKK-----MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL-------EEEQI 981
Query: 216 ALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLD 275
L D Q K+ + L +E R E T + L K+K H+AM D
Sbjct: 982 ILED---QNCKLAKEKKL--LEDRIAEFTTNLTEEEEKSKSLAKLKNK-HEAMIT----D 1031
Query: 276 KEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLE 335
E LR+E EK+ ++E+ R K E + L Q+AE +A ++ +L+
Sbjct: 1032 LEERLRRE-----EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 336 KSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQAD 372
++ E + M+LK R+ +++ E L+++
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123
Score = 44.7 bits (104), Expect = 1e-04
Identities = 47/251 (18%), Positives = 110/251 (43%), Gaps = 20/251 (7%)
Query: 78 RGRRRSKSRTGMDR------GVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEA 131
R RR K R +++ G ++ +Q ++A++K L A E +LQ A
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL----AKKEEELQAALA 1090
Query: 132 IIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLR- 190
+EE + + +++ E E I + + + K K D+ + +K +L
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 191 -----LKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQ 245
L+ +R++ + L++ E H+ Q+++ +++Q +E + + ++ +
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 246 LKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQV---EEDRAKA 302
+K + Q L + +L +++ L + +++ +E + + LQV E +R +
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE-AQLQELQVKFNEGERVRT 1269
Query: 303 EAVNKRLRKQL 313
E +K + Q+
Sbjct: 1270 ELADKVTKLQV 1280
Score = 43.1 bits (100), Expect = 4e-04
Identities = 49/249 (19%), Positives = 108/249 (43%), Gaps = 37/249 (14%)
Query: 99 QKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVS------------RE 146
+K+ ++ +++++++DL RA+ + + + EE E +E+ R
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 147 VHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKL-----RLKNVSLKVQRK 201
E E +ILK +++ Q I++M ++ E+L + K V +++
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQ-----IQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 202 KMLLQLRQKEEVSEAL------HDVDFQQLKIE------NAQFLETIEARNQ---ELTQL 246
K L+ + E +E D + ++ K+E +F E R + ++T+L
Sbjct: 1219 KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL 1278
Query: 247 KLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVN 306
++ N +L+ SK K + + L+ ++ +ELL++ ++ L + + E
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 307 KRLRKQLAE 315
R+QL E
Sbjct: 1339 NSFREQLEE 1347
Score = 39.7 bits (91), Expect = 0.004
Identities = 69/315 (21%), Positives = 124/315 (39%), Gaps = 34/315 (10%)
Query: 5 ESESVLSDSHEGSELELPVI-----QLCGLVEELSYVNSALKTETE-MFEKYYAKLEPRD 58
E ES +S+ E E E Q L EEL ALKTE E + A+ E R
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELE----ALKTELEDTLDSTAAQQELRS 1163
Query: 59 QRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHT 118
+R ++ +K + + A+ + + R QK +E+A+ + +
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMR------------QKHSQAVEELAEQLEQTKRV 1211
Query: 119 RANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDM 178
+AN E+ Q E E++ EV + + K+K Q++ +
Sbjct: 1212 KANLEKAKQ-------TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 179 NRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEA 238
R R + +K+ L+V+ + L Q + S L DF L+ + E ++
Sbjct: 1265 ERVRTELADKV----TKLQVELDNVTGLLSQSDSKSSKLTK-DFSALESQLQDTQELLQE 1319
Query: 239 RNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEED 298
N++ L N+++ +L + E NL+K+I + ++K+
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 299 RAKAEAVNKRLRKQL 313
AE V ++L+K L
Sbjct: 1380 LETAEEVKRKLQKDL 1394
Score = 32.7 bits (73), Expect = 0.55
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 4/105 (3%)
Query: 97 ADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILK 156
A +++ +K++ D+ + R NAE+ ++ ++A R ++ R++ E E++ +
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQ----YKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Query: 157 AISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRK 201
A + ++ + + + MNR ++K KLR ++ V R+
Sbjct: 1889 ANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRR 1933
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 48.5 bits (114), Expect = 1e-05
Identities = 73/314 (23%), Positives = 146/314 (46%), Gaps = 62/314 (19%)
Query: 81 RRSKSRTGM--DRGVGLTA---DQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEE 135
+R TGM D+ +G+ A +++LE ++K D+++D+ + RA+ ++++E+
Sbjct: 1961 QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP---RDSVVED 2017
Query: 136 AEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVS 195
++ + ++H EK K + K SI + + +++N+K L +N+
Sbjct: 2018 LHLQNRYLQEKLHALEKQFSKD-TYSKPSISGIESDDHCQREQELQKENLK--LSSENIE 2074
Query: 196 LKVQRKKMLLQL-RQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLS--SGN 252
LK Q ++ L R K +V + +F LK E A+ ++L ++ S SG
Sbjct: 2075 LKFQLEQANKDLPRLKNQVRDLKEMCEF--LKKEKAEV-------QRKLGHVRGSGRSGK 2125
Query: 253 TLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVE--------EDRAKAEA 304
T+ L+K I L K+++EK+++E Q++ E A E
Sbjct: 2126 TIP-----------------ELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168
Query: 305 VNKRLRKQLAEFRAP---------QVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGH 355
N++L+ +L + +A + T EKI+ A+ E+ + +++ + AE
Sbjct: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKII-AENERLRKELKKETDAAEKL---- 2223
Query: 356 RKAWNRMKITNEQL 369
R A N ++I NE++
Sbjct: 2224 RIAKNNLEILNEKM 2237
Score = 42.0 bits (97), Expect = 0.001
Identities = 92/393 (23%), Positives = 166/393 (42%), Gaps = 78/393 (19%)
Query: 11 SDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSE-IKI 69
SD H E EL L +LS N LK + E K +L+ + + + E +K
Sbjct: 2051 SDDHCQREQELQKENL-----KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKK 2105
Query: 70 SAADYAQFRGRRRSKSRTG-----MDRGVGLTADQKLELVQKEVADMKDD----LRHTRA 120
A+ + G R R+G +++ +GL + +E VQ+E +K A
Sbjct: 2106 EKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMK-KVVEKVQRENEQLKKASGILTSEKMA 2164
Query: 121 NAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNR 180
N E++ + +A +E+ + +E SK KG T+K++ E + +
Sbjct: 2165 NIEQENEKLKAELEKLKAHLGHQLSMHYE---------SKTKG----TEKIIAENERLRK 2211
Query: 181 ---RRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENA------- 230
+ + EKLR+ +L++ +KM +QL EE + L + + ++E A
Sbjct: 2212 ELKKETDAAEKLRIAKNNLEILNEKMTVQL---EETGKRLQFAESRGPQLEGADSKSWKS 2268
Query: 231 -----------QFLET-IEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEI 278
+ LET I +NQ +T LK Q++ + K + +L+++I
Sbjct: 2269 IVVTRMYETKLKELETDIAKKNQSITDLK-------QLVKEATEREQKVNKYNEDLEQQI 2321
Query: 279 LLRKELLEKIE-----KETLQV------EEDRAKAEAVNK---RLRKQLAEFRAPQVMTY 324
+ K + E E K LQV + D+ KAE +++ + AE P
Sbjct: 2322 KILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDA-DQ 2380
Query: 325 VREKILNADLEKSIRMWERKVEIAEMSLKGHRK 357
++EKI DLE ++M + + + + +K +K
Sbjct: 2381 LKEKI--KDLETQLKMSDLEKQHLKEEIKKLKK 2411
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/172 (19%), Positives = 80/172 (46%), Gaps = 11/172 (6%)
Query: 145 REVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKML 204
+E+ + + D L + ++L + ++ E + +++N+ R+ +K++ +++
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVE 67
Query: 205 LQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKL 264
L L + E+ E +Q K EN + ++ N+ + + G + L +L
Sbjct: 68 LALEEVEKAGE-------EQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL 120
Query: 265 HKAMEI----YLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQ 312
K +E +++KE+ K++ E++ + E + +K NKRL+K+
Sbjct: 121 EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
Score = 37.4 bits (85), Expect = 0.022
Identities = 63/328 (19%), Positives = 143/328 (43%), Gaps = 26/328 (7%)
Query: 53 KLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKE-VADM 111
K+E + R + + K A YA+ GR R+K + + L L Q+E +
Sbjct: 1230 KMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKT 1289
Query: 112 KDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKV 171
L++ + +++++ + E + E+ ++ E +++ + KG+ QKV
Sbjct: 1290 MIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGA----QKV 1344
Query: 172 MKYIEDMNRRRDNMK-EKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENA 230
+ + +MK E+LRL+ + L + K +++ + ++ L+ E
Sbjct: 1345 INW---------HMKIEELRLQELKLNRELVKDKEEIKYLNNIISE-YERTISSLEEEIV 1394
Query: 231 QFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNL-----DKEILLRKEL- 284
Q + E R Q ++ L + + ++++ A + + D + L +L
Sbjct: 1395 QQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLE 1454
Query: 285 --LEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWE 342
L KI++ + E RA +++ ++L+++ + R + R+K++N + E
Sbjct: 1455 IALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAE 1514
Query: 343 RKVEIAEMSLKG-HRKAWNRMKITNEQL 369
R+ IAE+ K K+ + +KI ++ +
Sbjct: 1515 REKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Score = 34.7 bits (78), Expect = 0.14
Identities = 75/347 (21%), Positives = 143/347 (41%), Gaps = 62/347 (17%)
Query: 26 LCGLVEELSYVNSALK-----TETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGR 80
L L+ +L V+ L+ TE ++ E KL+ ++ + ++K D +
Sbjct: 1637 LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1696
Query: 81 RRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRW 140
+ +S+ K EL ++ A+ + R ER L+ A+ E+ +
Sbjct: 1697 SQKESQC-----------LKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKEKQQKAL 1744
Query: 141 SEVSREVHE-----FEKDILKAISKKKGSILATQKVMKY-------IEDMNRRRDNMKEK 188
S E+ E+ I+ A S+K+ + Q V ++ +ED+N +KE
Sbjct: 1745 SRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEA 1804
Query: 189 LR------------LKNVSLKVQRKKMLLQ--LRQKEEVSEALHDVDFQQLKIENAQFLE 234
L+ L +++ ++Q+K+ LR+KEE+ + EN +
Sbjct: 1805 LKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQ------------ENDELKR 1852
Query: 235 TIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQ 294
I+ L Q K + N ++ + K+ K +E L E + K + EK KE L
Sbjct: 1853 QIKRLTSGL-QGKPLTDNKQSLIEELQRKV-KKLENQLEGKVEEVDLKPMKEKNAKEELI 1910
Query: 295 VEED----RAKAEAVNKRLRKQLAE-FRAPQVMTYVREKILNADLEK 336
E+ +AK E + +L+++ E F + + +++ AD EK
Sbjct: 1911 RWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
Score = 28.9 bits (63), Expect = 7.9
Identities = 28/139 (20%), Positives = 61/139 (43%), Gaps = 9/139 (6%)
Query: 239 RNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEED 298
R +EL L S + ++V K + ++ + ++ + +E +E + E+
Sbjct: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79
Query: 299 RAKAE-AVNKRLRKQLAEFRAPQVMT------YVREKILNADLEKSIRMWERKVEIAEMS 351
+AK E + ++ K E Q ++R +I LEK + +R++E E
Sbjct: 80 QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEI--CQLEKQLEQKDRELEDMEKE 137
Query: 352 LKGHRKAWNRMKITNEQLQ 370
L+ +K ++ + NE+ +
Sbjct: 138 LEKEKKVNEQLALRNEEAE 156
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/258 (24%), Positives = 118/258 (45%), Gaps = 34/258 (13%)
Query: 80 RRRSKSRTGMDRGVGLTADQK---LELVQKEVADMK--DDLRHTRA--NAERDLQHHEAI 132
RRR++ + G QK LE+ K+V + D+ RH ++ A + +Q
Sbjct: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
Query: 133 IE--------EAEIRW---SEVSREVHEFEKDILKAISKKKGSILAT-----QKVMKYIE 176
IE EA+ RW +E+S+ + ++++I+ ++ + I T Q M+ E
Sbjct: 1327 IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEE 1386
Query: 177 DMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKI---ENAQFL 233
D + R + + L +N SL + K++ L Q E + + D QQ K E +Q
Sbjct: 1387 DTSGYRAQI-DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE-DIQQQKATGSEVSQRK 1444
Query: 234 ETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETL 293
+ +E +++TQ++ YK L A + + +KEI K+L++K +
Sbjct: 1445 QQLEVELRQVTQMRTEESVR------YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
Query: 294 QVEEDRAKAEAVNKRLRK 311
+E++ A+ + V L+K
Sbjct: 1499 CLEDENARLQRVQYDLQK 1516
Score = 38.5 bits (88), Expect = 0.010
Identities = 47/201 (23%), Positives = 86/201 (42%), Gaps = 33/201 (16%)
Query: 173 KYIEDMNRRRDNMK---------EKLRLKNVSLKVQRKKMLLQLRQKEEV--SEALHDVD 221
+YIE + R D + E L+LKN ++V +++ L E D +
Sbjct: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
Query: 222 FQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLR 281
Q+ + E +QF + + + Q +L + Q NLDK
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ-----------------NLDKCYGQI 1104
Query: 282 KELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKIL---NADLEKSI 338
KEL EKI + T ++E+++ + ++V R +Q ++ Q ++ L + EK+I
Sbjct: 1105 KELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI 1164
Query: 339 RMWERKVEIAEMSL--KGHRK 357
+ E ++E + L +G RK
Sbjct: 1165 KEKEYEIERLRVLLQEEGTRK 1185
Score = 34.7 bits (78), Expect = 0.14
Identities = 63/267 (23%), Positives = 109/267 (40%), Gaps = 42/267 (15%)
Query: 24 IQLCGLVEELSYVNSALKTETEMFEKYYAKLEPR------------DQRPPRLSEIKISA 71
++L GL+ +L L+ E E F+K + R +R L +IK+
Sbjct: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
Query: 72 ADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEA 131
D A+ + +R Q+LE ++++ ++DL + R
Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLNQWKTQYSR------- 1873
Query: 132 IIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRR--DNMKE-K 188
+E IR E RE E EK+ L++ I Q +K IE+ RR+ D+ +E +
Sbjct: 1874 --KEEAIRKIESEREKSEREKNSLRS------EIERLQAEIKRIEERCRRKLEDSTRETQ 1925
Query: 189 LRLKNVSLKVQRKKMLLQLR----QKEEVSEALHDVDFQQLKIENAQFLETIEARNQELT 244
+L+ + QR+ L+ R +E +E VD +L + + T +L
Sbjct: 1926 SQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA----MQLY 1981
Query: 245 QLKLSSGNTL-QVLNAYKSKLHKAMEI 270
+ +L TL ++L KS A EI
Sbjct: 1982 ECQLIDKTTLDKLLKGKKSVEEVASEI 2008
Score = 29.6 bits (65), Expect = 4.6
Identities = 41/236 (17%), Positives = 101/236 (42%), Gaps = 29/236 (12%)
Query: 81 RRSKSRTGMDRGVG-LTADQKLELVQKEVADMK---DDLRHTRANAERDLQHHEAIIEEA 136
RR +S D+ L +L++ +++ +DL+ R N ++++ + EA
Sbjct: 1735 RRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEA 1794
Query: 137 EIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSL 196
R E + + ++ + K K ++ + +++NR + ++ + R+K
Sbjct: 1795 SNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK---- 1850
Query: 197 KVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQV 256
QR + +K+++ L+ Q + E A + IE+ ++ + K S + ++
Sbjct: 1851 --QRLEC-----EKQQIQNDLNQWKTQYSRKEEA--IRKIESEREKSEREKNSLRSEIER 1901
Query: 257 LNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQ 312
L A ++ E R++L + + Q+E +R++ + +LR++
Sbjct: 1902 LQAEIKRI------------EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 48.1 bits (113), Expect = 1e-05
Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 30/288 (10%)
Query: 67 IKISAADYAQFRGRRRSKSRTGMDRGVGLTAD-QKLELVQKEVADMK---DDLRHTRANA 122
IK+ A F R T + L+ QK + ++EV K D L+
Sbjct: 968 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1027
Query: 123 ERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRR 182
++DL+ +IE++ +SR+ E K LK +S+K Y E N +
Sbjct: 1028 QKDLRDKTVLIEKSHEMERALSRKTDELNKQ-LKDLSQK------------YTEVKNVKE 1074
Query: 183 DNMKEKLRLKNVSLKVQR--KKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
++E + + L VQ +K + L Q E + ++L+ + LK E E
Sbjct: 1075 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQRCYEKEQ 1133
Query: 241 QELTQLKLSSGNTLQVLNAYKSK---LHKAMEIYLNLDKEILLRKELLEKIEKETLQVEE 297
Q +T+L Q+L K+ L + ++I +KE+ + K L + E+E+ E
Sbjct: 1134 QTVTKLH-------QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1186
Query: 298 DRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKV 345
+ +K ++ + ++ L + +V+ + K +DLE I K+
Sbjct: 1187 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1234
Score = 33.1 bits (74), Expect = 0.42
Identities = 51/226 (22%), Positives = 94/226 (41%), Gaps = 17/226 (7%)
Query: 100 KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEE-----AEIRWSEVSREVHEFEKDI 154
K E EV +++ ++ E + +IEE E+ E+ RE +
Sbjct: 539 KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTE 598
Query: 155 LKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVS 214
++ +K+ + LA + E+M N + K V ++ + +K L ++RQ +
Sbjct: 599 MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 658
Query: 215 EALHDVDFQQLK-IENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAME-IYL 272
E + Q +K E+ Q +E ++ EL G + L L K +E +YL
Sbjct: 659 ENVKAKLAQHVKPEEHEQVKSRLEQKSGEL-------GKKITELTLKNQTLQKEIEKVYL 711
Query: 273 N--LDKEILLRKELLEKIEKETLQVEEDRAKA-EAVNKRLRKQLAE 315
+ L KE + K L+V ED K+ +A+ L ++L +
Sbjct: 712 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 757
Score = 30.8 bits (68), Expect = 2.1
Identities = 57/280 (20%), Positives = 108/280 (38%), Gaps = 63/280 (22%)
Query: 95 LTADQKLELVQKEVA-DMK-------DDLRHTRANAERDLQHHEAIIEEAEIRWSEVSRE 146
LT + K V +V+ DMK DDL + + + +E+ + +S++
Sbjct: 723 LTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKD 782
Query: 147 VHEFEKDILKAISKKKGSILATQKVM---KYIEDMNRRRDNMKEKLRL---KNVSLKVQR 200
V E + +K I ++ K + ++ ++ +EK+ +N +LK
Sbjct: 783 VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
Query: 201 KKMLLQLRQKEEVSEALHDV--------------------DFQQLK---------IENAQ 231
+ ++ EEV L+D +F ++K +EN Q
Sbjct: 843 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ 902
Query: 232 --------FLETIEARNQELTQ-LKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRK 282
L EA+ L+Q ++ + ++L Y+ K E + L EI +K
Sbjct: 903 NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYR----KGQEEIVTLHAEIKAQK 958
Query: 283 ELLEKIEK-------ETLQVEEDRAKAEAVNKRLRKQLAE 315
+ L+ I++ + EE K +A K L+ QL+E
Sbjct: 959 KELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSE 998
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 48.1 bits (113), Expect = 1e-05
Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 30/288 (10%)
Query: 67 IKISAADYAQFRGRRRSKSRTGMDRGVGLTAD-QKLELVQKEVADMK---DDLRHTRANA 122
IK+ A F R T + L+ QK + ++EV K D L+
Sbjct: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1040
Query: 123 ERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRR 182
++DL+ +IE++ +SR+ E K LK +S+K Y E N +
Sbjct: 1041 QKDLRDKTVLIEKSHEMERALSRKTDELNKQ-LKDLSQK------------YTEVKNVKE 1087
Query: 183 DNMKEKLRLKNVSLKVQR--KKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARN 240
++E + + L VQ +K + L Q E + ++L+ + LK E E
Sbjct: 1088 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQRCYEKEQ 1146
Query: 241 QELTQLKLSSGNTLQVLNAYKSK---LHKAMEIYLNLDKEILLRKELLEKIEKETLQVEE 297
Q +T+L Q+L K+ L + ++I +KE+ + K L + E+E+ E
Sbjct: 1147 QTVTKLH-------QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Query: 298 DRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKV 345
+ +K ++ + ++ L + +V+ + K +DLE I K+
Sbjct: 1200 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Score = 33.1 bits (74), Expect = 0.42
Identities = 51/226 (22%), Positives = 94/226 (41%), Gaps = 17/226 (7%)
Query: 100 KLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEE-----AEIRWSEVSREVHEFEKDI 154
K E EV +++ ++ E + +IEE E+ E+ RE +
Sbjct: 552 KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTE 611
Query: 155 LKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVS 214
++ +K+ + LA + E+M N + K V ++ + +K L ++RQ +
Sbjct: 612 MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Query: 215 EALHDVDFQQLK-IENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAME-IYL 272
E + Q +K E+ Q +E ++ EL G + L L K +E +YL
Sbjct: 672 ENVKAKLAQHVKPEEHEQVKSRLEQKSGEL-------GKKITELTLKNQTLQKEIEKVYL 724
Query: 273 N--LDKEILLRKELLEKIEKETLQVEEDRAKA-EAVNKRLRKQLAE 315
+ L KE + K L+V ED K+ +A+ L ++L +
Sbjct: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 770
Score = 30.8 bits (68), Expect = 2.1
Identities = 57/280 (20%), Positives = 108/280 (38%), Gaps = 63/280 (22%)
Query: 95 LTADQKLELVQKEVA-DMK-------DDLRHTRANAERDLQHHEAIIEEAEIRWSEVSRE 146
LT + K V +V+ DMK DDL + + + +E+ + +S++
Sbjct: 736 LTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKD 795
Query: 147 VHEFEKDILKAISKKKGSILATQKVM---KYIEDMNRRRDNMKEKLRL---KNVSLKVQR 200
V E + +K I ++ K + ++ ++ +EK+ +N +LK
Sbjct: 796 VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
Query: 201 KKMLLQLRQKEEVSEALHDV--------------------DFQQLK---------IENAQ 231
+ ++ EEV L+D +F ++K +EN Q
Sbjct: 856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ 915
Query: 232 --------FLETIEARNQELTQ-LKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRK 282
L EA+ L+Q ++ + ++L Y+ K E + L EI +K
Sbjct: 916 NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYR----KGQEEIVTLHAEIKAQK 971
Query: 283 ELLEKIEK-------ETLQVEEDRAKAEAVNKRLRKQLAE 315
+ L+ I++ + EE K +A K L+ QL+E
Sbjct: 972 KELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSE 1011
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,860,650
Number of Sequences: 37866
Number of extensions: 480858
Number of successful extensions: 3992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 605
Number of HSP's that attempted gapping in prelim test: 2732
Number of HSP's gapped (non-prelim): 1512
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.