Search of human proteins with 198041768

Search of human proteins with 198041768

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|198041768 synleurin [Homo sapiens]
         (622 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|198041768 synleurin [Homo sapiens]                                1237   0.0  
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               166   8e-41
gi|153251229 chondroadherin precursor [Homo sapiens]                  162   7e-40
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   160   2e-39
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   160   2e-39
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   157   2e-38
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   147   4e-35
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   146   5e-35
gi|225579152 insulin-like growth factor binding protein, acid la...   142   7e-34
gi|4826772 insulin-like growth factor binding protein, acid labi...   142   7e-34
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   142   9e-34
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   142   1e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   140   3e-33
gi|12007646 nyctalopin precursor [Homo sapiens]                       139   1e-32
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   139   1e-32
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   138   1e-32
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]            135   1e-31
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   135   1e-31
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   135   1e-31
gi|51317373 netrin-G1 ligand [Homo sapiens]                           134   3e-31
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         132   7e-31
gi|194440719 chondroadherin-like [Homo sapiens]                       130   3e-30
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            130   4e-30
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]            130   5e-30
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]            130   5e-30
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]            130   5e-30
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             128   2e-29
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             128   2e-29
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...   127   3e-29
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           126   7e-29

>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score = 1237 bits (3201), Expect = 0.0
 Identities = 622/622 (100%), Positives = 622/622 (100%)

Query: 1   MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPE 60
           MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPE
Sbjct: 1   MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPE 60

Query: 61  STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFI 120
           STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFI
Sbjct: 61  STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFI 120

Query: 121 KRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMV 180
           KRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMV
Sbjct: 121 KRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMV 180

Query: 181 ALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPI 240
           ALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPI
Sbjct: 181 ALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPI 240

Query: 241 EAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLK 300
           EAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLK
Sbjct: 241 EAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLK 300

Query: 301 NLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNP 360
           NLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNP
Sbjct: 301 NLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNP 360

Query: 361 WECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKS 420
           WECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKS
Sbjct: 361 WECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKS 420

Query: 421 PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTA 480
           PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTA
Sbjct: 421 PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTA 480

Query: 481 VLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFDILLAFFILACV 540
           VLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFDILLAFFILACV
Sbjct: 481 VLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFDILLAFFILACV 540

Query: 541 LIIFLIYKVVQFKQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQI 600
           LIIFLIYKVVQFKQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQI
Sbjct: 541 LIIFLIYKVVQFKQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQI 600

Query: 601 RLHKQIVPENEAQVILFEHSAL 622
           RLHKQIVPENEAQVILFEHSAL
Sbjct: 601 RLHKQIVPENEAQVILFEHSAL 622


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  166 bits (419), Expect = 8e-41
 Identities = 126/402 (31%), Positives = 193/402 (48%), Gaps = 15/402 (3%)

Query: 11  LRLFLVVT-CYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNF----PESTVFL 65
           LRL LVV  C  L  L + +  C   C     + + C N GL  +PK      P   +  
Sbjct: 7   LRLLLVVCGCLALPPLAEPV--CPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTY 64

Query: 66  YLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDP 125
            L GN I+ I   +   L  L  L L  + I  ++PK F +L  L  L+L NN ++ L P
Sbjct: 65  SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAP 124

Query: 126 GIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRIL 185
           G    L  LR LY   N++S + RG F  L S+  L L  N L  L    F  +  L  L
Sbjct: 125 GTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYL 184

Query: 186 DLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA--FEVLKSLRRLSLSHNPIEAI 243
            L +N I  + ++ F  L  L  L L +N L     +A  F  L+SL  L LS N ++ +
Sbjct: 185 HLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHL 244

Query: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI 303
            P  F+ L  L  L L+ +++ ++  + F G+  L+ L L  N L  L +     L +L 
Sbjct: 245 GPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304

Query: 304 YLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWEC 363
            L L  N + ++   TF ++G  L+ L+L  N L+AL   +     +L  L  + N W C
Sbjct: 305 ALDLSGNELSALHPATFGHLG-RLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTC 363

Query: 364 NCKLLGLRDWLA-----SSAITLNIYCQNPPSMRGRALRYIN 400
           +C+L GL+ W+         +T+ + C++PP++RG+ L Y++
Sbjct: 364 DCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLD 405


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  162 bits (411), Expect = 7e-40
 Identities = 116/389 (29%), Positives = 176/389 (45%), Gaps = 54/389 (13%)

Query: 11  LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQ-INCRNLGLSSIPKNFPESTVFLYLTG 69
           +R  L+++  LL  L   +  C   C   +  Q + C  +GL  IPK   E T  L L  
Sbjct: 2   VRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQR 60

Query: 70  NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129
           NN   +  +    + +LV+L+L +  I  V   AF  L+ L +L+L++N I+ L  G F 
Sbjct: 61  NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 120

Query: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
            L  L  LYL +N+V+ +PRG+ + LV++  L L  N++  L +G F G   LR L LS 
Sbjct: 121 DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE 180

Query: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
           N +  +       +ENLA  ++  N L+  PS A   L+ +  L LSHNP+++I   AF+
Sbjct: 181 NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ 240

Query: 250 GLAN-LEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLD 308
                LE L L N+ +   +   F G+  LKH+ L +N L  L S+              
Sbjct: 241 SFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF------------- 287

Query: 309 RNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLL 368
                                                 P  SL  L   +NPW+C C+L 
Sbjct: 288 --------------------------------------PFDSLETLALTNNPWKCTCQLR 309

Query: 369 GLRDWLASSAITLNIYCQNPPSMRGRALR 397
           GLR WL + A   +  C +P   +G+ +R
Sbjct: 310 GLRRWLEAKASRPDATCASPAKFKGQHIR 338


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  160 bits (406), Expect = 2e-39
 Identities = 111/366 (30%), Positives = 185/366 (50%), Gaps = 6/366 (1%)

Query: 60  ESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF 119
           +S   L L+ N +  I  +  +   +L  L L  +++ Y+   AF  L  L  L L  N 
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 190

Query: 120 IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGM 179
           +  + P +F+ L NL+ L L  N+++ +P G F+ LV++Q L LQ+N++ +L  G F   
Sbjct: 191 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 250

Query: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239
             L+ L LSNN+I ++  S F  L  L  L L  N+L ++    F  + +LR L L  N 
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 310

Query: 240 IEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLL 299
           I ++    F  L  L+ L+L  ++I  ++   F+G+  L+ L L  N L++L+ + F +L
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 370

Query: 300 KNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            NL  + L  NR+  +  + F N+   L  + L  N L  L   +   L  L  L+   N
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVN-GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429

Query: 360 PWECNCKLLGLRDWLASSAITLNI----YCQNPPSMRGRALRYINITNCVTSSINVSRAW 415
           PW C+  +L LR+WL  +   L       C +P ++RG++L  IN+ N    S++V    
Sbjct: 430 PWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINV-NVAVPSVHVPEVP 488

Query: 416 AVVKSP 421
           +  ++P
Sbjct: 489 SYPETP 494



 Score =  160 bits (404), Expect = 4e-39
 Identities = 103/329 (31%), Positives = 164/329 (49%), Gaps = 1/329 (0%)

Query: 31  GCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALY 90
           GC S C      Q+ C    + ++P   P + + L +   +I+ +NES    + +L+AL 
Sbjct: 30  GCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 89

Query: 91  LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRG 150
           ++ + +  + P AF  L  L +L L NN ++ L  G+F+GL +L +L L  NQ+  +   
Sbjct: 90  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149

Query: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
            F+   +++ L L  N L  +  G F  +V L  L+L  N++  IS   FQHL NL  L 
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209

Query: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD 270
           L  N LT +P   F+ L +L+ L+L  N I  + P  F    NL+ L L N+ I  +   
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 269

Query: 271 GFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKIL 330
            F  +  L  L L  N L+ L+   F  + NL  L L  N I S+ ++ F N+   L++L
Sbjct: 270 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL-RQLQVL 328

Query: 331 NLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            LS N ++ + P     L+ L  L  ++N
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTN 357


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  160 bits (406), Expect = 2e-39
 Identities = 111/366 (30%), Positives = 185/366 (50%), Gaps = 6/366 (1%)

Query: 60  ESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF 119
           +S   L L+ N +  I  +  +   +L  L L  +++ Y+   AF  L  L  L L  N 
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184

Query: 120 IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGM 179
           +  + P +F+ L NL+ L L  N+++ +P G F+ LV++Q L LQ+N++ +L  G F   
Sbjct: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 244

Query: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239
             L+ L LSNN+I ++  S F  L  L  L L  N+L ++    F  + +LR L L  N 
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304

Query: 240 IEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLL 299
           I ++    F  L  L+ L+L  ++I  ++   F+G+  L+ L L  N L++L+ + F +L
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364

Query: 300 KNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            NL  + L  NR+  +  + F N+   L  + L  N L  L   +   L  L  L+   N
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVN-GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423

Query: 360 PWECNCKLLGLRDWLASSAITLNI----YCQNPPSMRGRALRYINITNCVTSSINVSRAW 415
           PW C+  +L LR+WL  +   L       C +P ++RG++L  IN+ N    S++V    
Sbjct: 424 PWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINV-NVAVPSVHVPEVP 482

Query: 416 AVVKSP 421
           +  ++P
Sbjct: 483 SYPETP 488



 Score =  160 bits (404), Expect = 4e-39
 Identities = 103/329 (31%), Positives = 164/329 (49%), Gaps = 1/329 (0%)

Query: 31  GCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALY 90
           GC S C      Q+ C    + ++P   P + + L +   +I+ +NES    + +L+AL 
Sbjct: 24  GCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83

Query: 91  LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRG 150
           ++ + +  + P AF  L  L +L L NN ++ L  G+F+GL +L +L L  NQ+  +   
Sbjct: 84  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143

Query: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
            F+   +++ L L  N L  +  G F  +V L  L+L  N++  IS   FQHL NL  L 
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203

Query: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD 270
           L  N LT +P   F+ L +L+ L+L  N I  + P  F    NL+ L L N+ I  +   
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263

Query: 271 GFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKIL 330
            F  +  L  L L  N L+ L+   F  + NL  L L  N I S+ ++ F N+   L++L
Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL-RQLQVL 322

Query: 331 NLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            LS N ++ + P     L+ L  L  ++N
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTN 351


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  157 bits (398), Expect = 2e-38
 Identities = 127/430 (29%), Positives = 198/430 (46%), Gaps = 53/430 (12%)

Query: 22  LLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPEST---VFL---YLTGNNISYI 75
           LLLL +    C   C  C  +++ C +  L+++P + P  T   +F+   + T    ++ 
Sbjct: 12  LLLLARPAQPCPMGCD-CFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFG 70

Query: 76  NESELT------------------GLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNN 117
           +   LT                  GL  L  L +  S+ L +    F  L  L  L LN 
Sbjct: 71  SNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNF 130

Query: 118 NFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFV 177
           N ++ L  G+F+ L  L +L+LQ NQ+  +PR +F  L  ++ LNL +N L  L    F 
Sbjct: 131 NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFH 190

Query: 178 GMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH 237
            + +L+ L LSNN +  + +  F  L +L  L+L SNN++++P   F  L  L RL L  
Sbjct: 191 PLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQR 250

Query: 238 NPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFS 297
           N I  +    F  L NL +L L+ + +R +    F+    L  L L+HN LE +   TF+
Sbjct: 251 NAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFA 310

Query: 298 LLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLS-------- 349
            L NL  L L  N I  +    F ++   +K L L  NNLTALHP + + LS        
Sbjct: 311 HLSNLRSLMLSYNAITHLPAGIFRDLEELVK-LYLGSNNLTALHPALFQNLSKLELLSLS 369

Query: 350 ----------------SLIHLQANSNPWECNCKLLGLRDWL---ASSAITLNIYCQNPPS 390
                           +L +L  + NPW+C+C L  L +WL       + +  YC  P  
Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAY 429

Query: 391 MRGRALRYIN 400
           ++G+ +  +N
Sbjct: 430 LKGQVVPALN 439


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  147 bits (370), Expect = 4e-35
 Identities = 124/397 (31%), Positives = 190/397 (47%), Gaps = 38/397 (9%)

Query: 33  SSVCQLCTGRQINCRNLGLSSIPKNFPEST--VFLYLTGNNISYINESELTGLHSLVALY 90
           SS+  L + R++   N  L +IP   P S     L L GN I  I    L    SL  L 
Sbjct: 32  SSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLD 91

Query: 91  LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLN-LRNLYLQYNQVSFVPR 149
           L ++NI  +   AF  L+ L +L+LN+N +  ++PG F  L N L  L L  N++S +P 
Sbjct: 92  LSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP 149

Query: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACL 209
            +F  L  +Q+L L RN++  +   TF G+ AL+ L +  N + ++ +  F  L N+  L
Sbjct: 150 KMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEIL 208

Query: 210 YLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA---------------------- 247
            L  NNLT++       L  L+ L LS N I  I P A                      
Sbjct: 209 QLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDD 268

Query: 248 --FKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHND----LENLNSDTFSLLKN 301
             F GL+ L  L + N+R+  +    F G+++LK L L +N+    +E++N   FS L  
Sbjct: 269 SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDK 327

Query: 302 LIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPW 361
           L  L L  NRI SI    F  + A L+ L+LS N + +L       +  L  L  N++  
Sbjct: 328 LRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386

Query: 362 ECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396
            C+C+L  L  W+A +     +N  C +P  ++GR++
Sbjct: 387 LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 6/199 (3%)

Query: 162 NLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPS 221
           +L  NRL+ + + +   + +LR + L+NN +  I   G     N+  L L  N + ++  
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG-PVSANITLLSLAGNRIVEILP 78

Query: 222 NAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI-NNLKH 280
              +  +SL  L LS N I  +Q  AF  L  L+YL L ++R+ ++    F  + N L  
Sbjct: 79  EHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLV 136

Query: 281 LILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340
           L L+ N +  +    F  L  L +L+L+RN+I ++D  TF+ +GA LK L +  N +T L
Sbjct: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGA-LKSLKMQRNGVTKL 194

Query: 341 HPRVLKPLSSLIHLQANSN 359
                  LS++  LQ + N
Sbjct: 195 MDGAFWGLSNMEILQLDHN 213


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  146 bits (369), Expect = 5e-35
 Identities = 125/404 (30%), Positives = 184/404 (45%), Gaps = 79/404 (19%)

Query: 31  GCSSVCQL-CTGR---QINCRNLGLSSIPKNFPESTVFLYLTGNNIS------------- 73
           GC + C     GR   +++C +LGLS +P N    T +L L+ NNIS             
Sbjct: 33  GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92

Query: 74  -----------YINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKR 122
                      YI +   TGL+SL  L L N+ + +V  +A   LR L  L L+ N I  
Sbjct: 93  EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152

Query: 123 LDPGIFKGLLNLRNLYLQ------------------------YNQVSFVPRGVFNDLVSV 158
           + P  F GL +LR+L+L                          N++  +P   F +L S+
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212

Query: 159 QYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTK 218
             L+L  NR+  LG   F G+ +L  LDL+ NN+     +  + L NL  L   SNN+  
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP-TAIRTLSNLKELGFHSNNIRS 271

Query: 219 VPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK-----------------------GLANLE 255
           +P  AF    SL  +    NPI+ +   AF+                       G ANLE
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331

Query: 256 YLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISI 315
            L L  ++I ++ +   + + NL+ L LS+N LE+L S  FS+ + L  + L  N I  I
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389

Query: 316 DNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
             DTF+ +  SL+ LNL++N +  +HP     L SLI L  +SN
Sbjct: 390 KVDTFQQL-LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 63/186 (33%), Positives = 88/186 (47%), Gaps = 3/186 (1%)

Query: 70  NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129
           NNI  I E    G  SL+ ++  ++ I +V   AF  L  L  L LN        P +  
Sbjct: 267 NNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDL-T 325

Query: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
           G  NL +L L   Q+S +P+ V N L ++Q L+L  N L  L S  F     L+ +DL +
Sbjct: 326 GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRH 383

Query: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
           N I  I    FQ L +L  L L  N +  +  NAF  L SL +L LS N + +       
Sbjct: 384 NEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLH 443

Query: 250 GLANLE 255
           GL +L+
Sbjct: 444 GLTHLK 449



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 77/263 (29%), Positives = 115/263 (43%), Gaps = 27/263 (10%)

Query: 61  STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFI 120
           S V L+L  N I  + +    GLHSL  L L N N L  +P A   L +L  L  ++N I
Sbjct: 211 SLVVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLDEFPTAIRTLSNLKELGFHSNNI 269

Query: 121 KRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQ-RNRLTVLGSGTFVGM 179
           + +    F G  +L  ++   N + FV R  F  L  ++ L L   +++T     T  G 
Sbjct: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLT--GT 327

Query: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPS------------------ 221
             L  L L+   I  + ++    L NL  L L  N L  +PS                  
Sbjct: 328 ANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIY 387

Query: 222 ----NAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINN 277
               + F+ L SLR L+L+ N I  I P AF  L +L  L L ++ + +    G  G+ +
Sbjct: 388 EIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTH 447

Query: 278 LKHLILSHNDLENLNSDTFSLLK 300
           LK L  +H     ++S+ F  LK
Sbjct: 448 LK-LTGNHALQSLISSENFPELK 469


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  142 bits (359), Expect = 7e-34
 Identities = 103/314 (32%), Positives = 155/314 (49%), Gaps = 1/314 (0%)

Query: 46  CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105
           C +  L+ +P   P  T  L+L GNN+S +  +    L SL  L L    +  + P+A +
Sbjct: 98  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157

Query: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
            L +L  L L  N ++ L  G F     L +L L  N++S +  G+F  L S+  LNL  
Sbjct: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217

Query: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFE 225
           N L VL    F G+ +LR L L+ N +  +  + F  L  L  L L  N L  + +N F 
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277

Query: 226 VLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSH 285
            L  L++L L  N I A+ P AF GL  L +L L ++R+  +  D F G+  L+ L LSH
Sbjct: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337

Query: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
           N + +L   TF  L  L  L+L  NRI  +   +FE +G  L++L L  N L  +     
Sbjct: 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG-QLEVLTLDHNQLQEVKAGAF 396

Query: 346 KPLSSLIHLQANSN 359
             L+++  +  + N
Sbjct: 397 LGLTNVAVMNLSGN 410



 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/374 (29%), Positives = 163/374 (43%), Gaps = 42/374 (11%)

Query: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
           L L+ N +  I  +    L  L  LYLD + I  V P AF+ L+ L +L L++N +  L 
Sbjct: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320

Query: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
              F GLL LR L L +N ++ +    F DL  ++ L L  NR+  L   +F G+  L +
Sbjct: 321 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 380

Query: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
           L L +N +  +    F  L N+A + L  N L  +P   F  L  L  L L  + +  I+
Sbjct: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440

Query: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
           P  F GL+ L  L LK++ +  +      G+  L  L L+ N L +L    F  L  L Y
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500

Query: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANS------ 358
           L L RNR+  +  D    +  +   L++S N L AL   +L PL  L +L   +      
Sbjct: 501 LLLSRNRLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 559

Query: 359 --------------NPWECNCKLLGLRDWLASSAITL---------------------NI 383
                         NPW+C C L  LRD+   +   +                     NI
Sbjct: 560 TPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNI 619

Query: 384 YCQNPPSMRGRALR 397
            C +PP + G  LR
Sbjct: 620 TCASPPEVVGLDLR 633



 Score =  135 bits (341), Expect = 9e-32
 Identities = 93/295 (31%), Positives = 151/295 (51%), Gaps = 1/295 (0%)

Query: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
           L L  N+++ + ++   GL SL  L L  + + Y+ P  F  L  L  L L+ N ++ + 
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272

Query: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
             +F  L  L+ LYL  N ++ V  G F  L ++++L+L  NR+  L   TF G++ LR+
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332

Query: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
           L LS+N I  +    F+ L  L  L LG N + ++   +FE L  L  L+L HN ++ ++
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392

Query: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
             AF GL N+  + L  + +RN+    F G+  L  L L  + L  +   TF+ L  L  
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452

Query: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
           L L  N ++ I+  +   + A L  L+L+ N LT L  R+ + L  L +L  + N
Sbjct: 453 LFLKDNGLVGIEEQSLWGL-AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506



 Score =  134 bits (337), Expect = 2e-31
 Identities = 105/331 (31%), Positives = 155/331 (46%), Gaps = 4/331 (1%)

Query: 29  ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVA 88
           +LG  ++C L   R    R+L L +       +   L L+ N +S + +    GL SL  
Sbjct: 156 LLGLENLCHLHLERN-QLRSLALGTFAHT--PALASLGLSNNRLSRLEDGLFEGLGSLWD 212

Query: 89  LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148
           L L  +++  +   AF  L  L  L L  N +  L P +F GL  LR L L  N +  + 
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272

Query: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208
             VF  L  +Q L L RN +  +  G F+G+ ALR LDLS+N +  + E  F  L  L  
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332

Query: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
           L L  N +  +    F+ L  L  L L HN I  +   +F+GL  LE L L +++++ V 
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392

Query: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
              F G+ N+  + LS N L NL    F  L  L  L L+ + +  I   TF  + + L+
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLR 451

Query: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            L L  N L  +  + L  L+ L+ L   SN
Sbjct: 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  142 bits (359), Expect = 7e-34
 Identities = 103/314 (32%), Positives = 155/314 (49%), Gaps = 1/314 (0%)

Query: 46  CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105
           C +  L+ +P   P  T  L+L GNN+S +  +    L SL  L L    +  + P+A +
Sbjct: 60  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119

Query: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
            L +L  L L  N ++ L  G F     L +L L  N++S +  G+F  L S+  LNL  
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179

Query: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFE 225
           N L VL    F G+ +LR L L+ N +  +  + F  L  L  L L  N L  + +N F 
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239

Query: 226 VLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSH 285
            L  L++L L  N I A+ P AF GL  L +L L ++R+  +  D F G+  L+ L LSH
Sbjct: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299

Query: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
           N + +L   TF  L  L  L+L  NRI  +   +FE +G  L++L L  N L  +     
Sbjct: 300 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG-QLEVLTLDHNQLQEVKAGAF 358

Query: 346 KPLSSLIHLQANSN 359
             L+++  +  + N
Sbjct: 359 LGLTNVAVMNLSGN 372



 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/374 (29%), Positives = 163/374 (43%), Gaps = 42/374 (11%)

Query: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
           L L+ N +  I  +    L  L  LYLD + I  V P AF+ L+ L +L L++N +  L 
Sbjct: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282

Query: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
              F GLL LR L L +N ++ +    F DL  ++ L L  NR+  L   +F G+  L +
Sbjct: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342

Query: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
           L L +N +  +    F  L N+A + L  N L  +P   F  L  L  L L  + +  I+
Sbjct: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402

Query: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
           P  F GL+ L  L LK++ +  +      G+  L  L L+ N L +L    F  L  L Y
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462

Query: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANS------ 358
           L L RNR+  +  D    +  +   L++S N L AL   +L PL  L +L   +      
Sbjct: 463 LLLSRNRLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 521

Query: 359 --------------NPWECNCKLLGLRDWLASSAITL---------------------NI 383
                         NPW+C C L  LRD+   +   +                     NI
Sbjct: 522 TPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNI 581

Query: 384 YCQNPPSMRGRALR 397
            C +PP + G  LR
Sbjct: 582 TCASPPEVVGLDLR 595



 Score =  135 bits (341), Expect = 9e-32
 Identities = 93/295 (31%), Positives = 151/295 (51%), Gaps = 1/295 (0%)

Query: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
           L L  N+++ + ++   GL SL  L L  + + Y+ P  F  L  L  L L+ N ++ + 
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234

Query: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
             +F  L  L+ LYL  N ++ V  G F  L ++++L+L  NR+  L   TF G++ LR+
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294

Query: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
           L LS+N I  +    F+ L  L  L LG N + ++   +FE L  L  L+L HN ++ ++
Sbjct: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354

Query: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
             AF GL N+  + L  + +RN+    F G+  L  L L  + L  +   TF+ L  L  
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414

Query: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
           L L  N ++ I+  +   + A L  L+L+ N LT L  R+ + L  L +L  + N
Sbjct: 415 LFLKDNGLVGIEEQSLWGL-AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468



 Score =  134 bits (337), Expect = 2e-31
 Identities = 105/331 (31%), Positives = 155/331 (46%), Gaps = 4/331 (1%)

Query: 29  ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVA 88
           +LG  ++C L   R    R+L L +       +   L L+ N +S + +    GL SL  
Sbjct: 118 LLGLENLCHLHLERN-QLRSLALGTFAHT--PALASLGLSNNRLSRLEDGLFEGLGSLWD 174

Query: 89  LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148
           L L  +++  +   AF  L  L  L L  N +  L P +F GL  LR L L  N +  + 
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234

Query: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208
             VF  L  +Q L L RN +  +  G F+G+ ALR LDLS+N +  + E  F  L  L  
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294

Query: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
           L L  N +  +    F+ L  L  L L HN I  +   +F+GL  LE L L +++++ V 
Sbjct: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354

Query: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
              F G+ N+  + LS N L NL    F  L  L  L L+ + +  I   TF  + + L+
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLR 413

Query: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
            L L  N L  +  + L  L+ L+ L   SN
Sbjct: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  142 bits (358), Expect = 9e-34
 Identities = 120/439 (27%), Positives = 205/439 (46%), Gaps = 49/439 (11%)

Query: 57  NFPESTV-FLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFL 115
           +FP   + +L L+ N I+ +       L S + +   N N + + P    +L HL FL L
Sbjct: 163 SFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLEL 222

Query: 116 NNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGT 175
             N IK ++   F+GL +LR+L +Q N +S +  G F  L +++ L L+ N LT +  G 
Sbjct: 223 KRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGW 282

Query: 176 FVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSL 235
             G+  L+ L +S N I RIS   ++  + L+ L L  N LT++  +AF  L  L RL+L
Sbjct: 283 LYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNL 342

Query: 236 SHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSHNDLENLN 292
             N +  I    F+ L+NL+ L L+N+ I     D    F+G+ +L  LIL  N ++++ 
Sbjct: 343 GDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSIT 402

Query: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
              F  L++L +L L+ N I+SI  + F        ILN                 SSL+
Sbjct: 403 KKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN----------------TSSLL 446

Query: 353 HLQANSNPWECNCKLLGLRDWLASSAI--TLNIYCQNPPSMRGRALRYINITNCVTSSIN 410
                     C+C L  L  WL  +    ++N+ C +P  + G+++  +++ + V     
Sbjct: 447 ----------CDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDF- 495

Query: 411 VSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETENITFWER-------IPTSPA 463
                  +K     H  T + +    VT   + + ++++   T W +       + T   
Sbjct: 496 -------LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENF 548

Query: 464 GRFFQENAFGNPLETTAVL 482
            R++Q+   G  LE T++L
Sbjct: 549 VRYWQQ--AGEALEYTSIL 565



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 70/251 (27%), Positives = 112/251 (44%), Gaps = 29/251 (11%)

Query: 134 LRNLYLQYNQVSFVPRGVFNDLVS-VQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
           L+ + + YN+++ +P   F +  S +  L+L  N +  + +       AL  LDLS+N I
Sbjct: 99  LQEVKMNYNELTEIP--YFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156

Query: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKS----------------------- 229
             I  S F  ++ L  L L +N +T + +  F+ L S                       
Sbjct: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215

Query: 230 -LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDL 288
            L+ L L  N I+ ++   F+GL +L  L ++ + I  +    F G+NN++ L L HN+L
Sbjct: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275

Query: 289 ENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPL 348
             +N      L+ L  L + +N I  I  D +E     L  L+LS+N LT L       L
Sbjct: 276 TRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE-FCQRLSELDLSYNQLTRLDESAFVGL 334

Query: 349 SSLIHLQANSN 359
           S L  L    N
Sbjct: 335 SLLERLNLGDN 345


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  142 bits (357), Expect = 1e-33
 Identities = 112/338 (33%), Positives = 163/338 (48%), Gaps = 32/338 (9%)

Query: 65  LYLTGNNISYINESELTGL-HSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRL 123
           L L GN I  +      GL  SL+ L L  + I  +  +AF +L  L  L LN N I+ +
Sbjct: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLI 226

Query: 124 DPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
           +   F+GL +L  L LQ N +S +  G F  L  +  L+L+ N L  + SG+  G+ AL 
Sbjct: 227 EGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286

Query: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
            L LSNN+I RI   G+   + L  L L  NNLT++   +   L SL  L LSHN I  I
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346

Query: 244 QPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSHNDLENLNSDTFSLLK 300
              AFKGL +L  L L ++ I     D    FSG+++L  L L  N ++++    FS L+
Sbjct: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406

Query: 301 NLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNP 360
            L +L L  N I S+  D F  M            NL  LH               +S+ 
Sbjct: 407 GLEHLNLGGNAIRSVQFDAFVKM-----------KNLKELH--------------ISSDS 441

Query: 361 WECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396
           + C+C+L  L  WL    +   +   C +P S++G+++
Sbjct: 442 FLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSI 479



 Score =  131 bits (329), Expect = 2e-30
 Identities = 106/361 (29%), Positives = 168/361 (46%), Gaps = 39/361 (10%)

Query: 9   PCLRLFLVVTCYLLLLLHKEILG-------CSSVCQLCTGRQINCRNLGLSSIPKNFPES 61
           PCL L      +LLLL  + +         C++ C  C G  ++C   GL+++P + P  
Sbjct: 16  PCLLLL-----WLLLLRLEPVTAAAGPRAPCAAACT-CAGDSLDCGGRGLAALPGDLPSW 69

Query: 62  TVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIK 121
           T  L L+ N +S I+ +    L +L  +YL+N+ +  V P       H+  LFL +N I+
Sbjct: 70  TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIR 128

Query: 122 RLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVG--- 178
            ++    K  L+L  L L  N ++ V    F     ++ LNL  NR+  L  G F G   
Sbjct: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188

Query: 179 -MVALRI--------------------LDLSNNNILRISESGFQHLENLACLYLGSNNLT 217
            ++ LR+                    LDL+ N I  I    FQ L +L  L L  NN++
Sbjct: 189 SLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNIS 248

Query: 218 KVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINN 277
           K+   AF  L  +  L L +N +  +   +  GL  L  L L N+ I  + R G+S    
Sbjct: 249 KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQK 308

Query: 278 LKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNL 337
           L  L+LS N+L  L+ ++ + L +L  L+L  N I  I    F+ +  SL++L+L  N +
Sbjct: 309 LHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGL-RSLRVLDLDHNEI 367

Query: 338 T 338
           +
Sbjct: 368 S 368


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  140 bits (354), Expect = 3e-33
 Identities = 115/429 (26%), Positives = 192/429 (44%), Gaps = 61/429 (14%)

Query: 4   LQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCT-GRQINCRNLGLSSIPKNFPEST 62
           L  ++ C + FL +   L+ +     +GC + C+     + ++C    L +IP+  P  T
Sbjct: 2   LHTAISCWQPFLGLAVVLIFM--GSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIET 59

Query: 63  VFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKR 122
             L L+ N +  +N                        P+ F+    L  + L++N I  
Sbjct: 60  KILDLSKNRLKSVN------------------------PEEFISYPLLEEIDLSDNIIAN 95

Query: 123 LDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVAL 182
           ++PG F  L NLR+L L+ N++  VP GVF  L ++  L++  N++ +L    F  +  L
Sbjct: 96  VEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155

Query: 183 RILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEA 242
           + L++ +N+++ IS   F  L +L  L L   NLT VP+ A   L+SL  L L H  I  
Sbjct: 156 KSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215

Query: 243 IQPFAFKGL------------------------ANLEYLLLKNSRIRNVTRDGFSGINNL 278
           +  +AFK L                         NL  L + N+ +  V    F  +  L
Sbjct: 216 MPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYL 275

Query: 279 KHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLT 338
            HL LS+N +  + +  FS L  L  L +   ++ +I+  +F+ +   L++LN+S N L 
Sbjct: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGL-RFLRVLNVSQNLLE 334

Query: 339 ALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNI-----YCQNPPSMRG 393
            L   V     +L  L  N+NP  C+C+LL    W+     TL        C  P ++R 
Sbjct: 335 TLEENVFSSPRALEVLSINNNPLACDCRLL----WILQRQPTLQFGGQQPMCAGPDTIRE 390

Query: 394 RALRYINIT 402
           R+ +  + T
Sbjct: 391 RSFKDFHST 399


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  139 bits (349), Expect = 1e-32
 Identities = 115/396 (29%), Positives = 175/396 (44%), Gaps = 43/396 (10%)

Query: 21  LLLLLHKEILG-------------CSSVCQLCT---GRQINCRNLGLSSIPKNFPESTVF 64
           L+LLLH  +LG             C + C   T   G  + C   GL  +P   P   V 
Sbjct: 7   LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66

Query: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
           + L  N + ++ E                        +AF  L  L  L L +N +  + 
Sbjct: 67  IDLDRNGLRFLGE------------------------RAFGTLPSLRRLSLRHNNLSFIT 102

Query: 125 PGIFKGLLNLRNLYLQYN-QVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
           PG FKGL  L  L L +N  + ++    F  L  ++ L+L   RL  +       + ALR
Sbjct: 103 PGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALR 162

Query: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
            L  + +N+ R      + L NL   +L    +  V S++ + L+ LR LSL  N + A+
Sbjct: 163 EL-AAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV 221

Query: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI 303
              AF     LE+LLL ++ +  +  D F G+  L+ L L  N L+ +    F+ L  L 
Sbjct: 222 HAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELE 281

Query: 304 YLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWEC 363
            L LDRN I  ++   F+N+ + L  L+L+ N LT L     +P   L  L    NPW C
Sbjct: 282 LLYLDRNSIAFVEEGAFQNL-SGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 340

Query: 364 NCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYI 399
           +C+L  LRDW+  S    ++ C +P S+ G  L  +
Sbjct: 341 DCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQV 376


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  139 bits (349), Expect = 1e-32
 Identities = 117/398 (29%), Positives = 180/398 (45%), Gaps = 24/398 (6%)

Query: 17  VTCYLLLLLHKEIL---------GCSSVCQLCT--GRQINCRNLGLSSIPKNFPESTVFL 65
           +TC+L +L    +L         GC + C+ CT   R + C    L+++P   P  T  L
Sbjct: 1   MTCWLCVLSLPLLLLPAAPPPAGGCPARCE-CTVQTRAVACTRRRLTAVPDGIPAETRLL 59

Query: 66  YLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDP 125
            L+ N I  +N  +L  L +L  L L  + I +V P AF  L  L  L L  N +K + P
Sbjct: 60  ELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPP 119

Query: 126 GIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRIL 185
           G+F  L NL  L L  N++  +    F DL S++ L +  N L  +    F G++AL  L
Sbjct: 120 GVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEEL 179

Query: 186 DLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP-IEAIQ 244
            L   N+  +S     HL +L  L L    +  +    F  L  L  L + + P +E + 
Sbjct: 180 TLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVA 239

Query: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
             + +GL NL  L + ++ I  V         +L  L LSHN +  +   +F  L  L  
Sbjct: 240 AGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRE 298

Query: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECN 364
           L L    +  ++   F  +   +++LNLS N L+ L       +++L  L+ + NP  C+
Sbjct: 299 LHLAGALLAVVEPQAFLGL-RQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACD 357

Query: 365 CKLLGLRDWLASSAITLNI-----YCQNPPSMRGRALR 397
           C+LL    W+     TLN       C  P  +RG ALR
Sbjct: 358 CRLL----WIVQRRKTLNFDGRLPACATPAEVRGDALR 391


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  138 bits (348), Expect = 1e-32
 Identities = 105/353 (29%), Positives = 174/353 (49%), Gaps = 33/353 (9%)

Query: 51  LSSIPKNFPESTV-FLYLTGNNISYINESELTGL-HSLVALYLDNSNILYVYPKAFVQLR 108
           +S +   FP   + +LYL  N ++ +       L ++L+ L L+ + I  + PK F +L 
Sbjct: 157 ISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLP 215

Query: 109 HLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRL 168
            L  L LN N IK +D   F+GL  L++L +Q N V+ +  G F  L +++ L L  N L
Sbjct: 216 QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275

Query: 169 TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLK 228
           T +  G   G++ L+ L LS N I RIS   ++  + L+ L L  N+L+++  ++F  L 
Sbjct: 276 TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS 335

Query: 229 SLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSH 285
            L  L + +N +  I   AF+GL++L+ L LKN+ I     D    FSG++ L+ LIL  
Sbjct: 336 LLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQG 395

Query: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
           N + ++    F+ L  L +L L  N I+S+  + F  M                      
Sbjct: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM---------------------- 433

Query: 346 KPLSSLIHLQANSNPWECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396
                L  L  N++   C+C+L  L  W+A +     +N  C +P  ++GR++
Sbjct: 434 ---KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/415 (27%), Positives = 183/415 (44%), Gaps = 32/415 (7%)

Query: 14  FLVVTCYLLLLLHKEILGCSSV----C-QLCT---------------GRQINCRNLGLSS 53
           F++  C L+L L    L  SS+    C QLC                   ++C +L L+ 
Sbjct: 6   FVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTR 65

Query: 54  IPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFL 113
           IP N    T  L L  NNI+   + EL  L +L  L    +N   +       L  L  L
Sbjct: 66  IPSNLSSDTQVLLLQSNNIAKTVD-ELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 124

Query: 114 FLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGS 173
            L  N I  +     + L NL+ LY+ +NQ+S +    F  L ++  L+L  N+L V+ S
Sbjct: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184

Query: 174 GTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRL 233
             F     L IL +  N ++ I +  F+ L NL  L L    LT +P NA   L SL  L
Sbjct: 185 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 244

Query: 234 SLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHL-ILSHNDLENLN 292
           S   N +  +   A + + NL++L L  + I  +    F  +  LK L I +  +L +++
Sbjct: 245 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304

Query: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
                 L  L  L+   N  +S  +        +L+ L L+ N L A++ + ++ L +L 
Sbjct: 305 RYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLR 364

Query: 353 HLQANSNPWECNCKLLGLRDWLASSAIT------LNIYCQNPPSMRGRALRYINI 401
            +  +SNP  C+C +     W+ S+         L+++C  PP  +G  ++ + I
Sbjct: 365 EISIHSNPLRCDCVI----HWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLI 415


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score =  135 bits (340), Expect = 1e-31
 Identities = 109/415 (26%), Positives = 186/415 (44%), Gaps = 57/415 (13%)

Query: 13  LFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNI 72
           + +++   LL++L      C   C+ C G+ + C +   + IP+N    +  L L  N+I
Sbjct: 15  VLVLLPTLLLVMLTGAQRACPKNCR-CDGKIVYCESHAFADIPENISGGSQGLSLRFNSI 73

Query: 73  SYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLL 132
             +  ++  GL+ L+ LYL                        ++N+I  +D   F+G+ 
Sbjct: 74  QKLKSNQFAGLNQLIWLYL------------------------DHNYISSVDEDAFQGIR 109

Query: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
            L+ L L  N+++++    F+ + +++ L+L  N+L  L S  F G+  L IL L +N++
Sbjct: 110 RLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169

Query: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA 252
             +    FQ   NL  L LG N L  +  NAF  L  L+ L L HN    I    F  L 
Sbjct: 170 KTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLF 229

Query: 253 NLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRI 312
           NL  + L+ +RIR++++      ++L +L LS ND++ +   TF  L NL  L LD N++
Sbjct: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289

Query: 313 ISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRD 372
            +I  +T                         +    SLI +  + N WEC+  +  L  
Sbjct: 290 TNISQET-------------------------VNAWISLISITLSGNMWECSRSICPLFY 324

Query: 373 WLAS--SAITLNIYCQNPPSMRGR----ALRYINITNCVTSSINVSRAWAVVKSP 421
           WL +        + C  P  ++G     A+   NI + V   +N  R+  V ++P
Sbjct: 325 WLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSEV-QVVNTERSHLVPQTP 378


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score =  135 bits (340), Expect = 1e-31
 Identities = 109/415 (26%), Positives = 186/415 (44%), Gaps = 57/415 (13%)

Query: 13  LFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNI 72
           + +++   LL++L      C   C+ C G+ + C +   + IP+N    +  L L  N+I
Sbjct: 15  VLVLLPTLLLVMLTGAQRACPKNCR-CDGKIVYCESHAFADIPENISGGSQGLSLRFNSI 73

Query: 73  SYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLL 132
             +  ++  GL+ L+ LYL                        ++N+I  +D   F+G+ 
Sbjct: 74  QKLKSNQFAGLNQLIWLYL------------------------DHNYISSVDEDAFQGIR 109

Query: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
            L+ L L  N+++++    F+ + +++ L+L  N+L  L S  F G+  L IL L +N++
Sbjct: 110 RLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169

Query: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA 252
             +    FQ   NL  L LG N L  +  NAF  L  L+ L L HN    I    F  L 
Sbjct: 170 KTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLF 229

Query: 253 NLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRI 312
           NL  + L+ +RIR++++      ++L +L LS ND++ +   TF  L NL  L LD N++
Sbjct: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289

Query: 313 ISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRD 372
            +I  +T                         +    SLI +  + N WEC+  +  L  
Sbjct: 290 TNISQET-------------------------VNAWISLISITLSGNMWECSRSICPLFY 324

Query: 373 WLAS--SAITLNIYCQNPPSMRGR----ALRYINITNCVTSSINVSRAWAVVKSP 421
           WL +        + C  P  ++G     A+   NI + V   +N  R+  V ++P
Sbjct: 325 WLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSEV-QVVNTERSHLVPQTP 378


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  134 bits (336), Expect = 3e-31
 Identities = 89/266 (33%), Positives = 133/266 (50%), Gaps = 7/266 (2%)

Query: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
           N R L L  NQ+  +    F  L  ++ L L RN +  +  G F G+  L  L+L +N +
Sbjct: 77  NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136

Query: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH-NPIEAIQPFAFKGL 251
             I    F +L  L  L+L +N +  +PS AF  + SLRRL L     +  I   AF+GL
Sbjct: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196

Query: 252 ANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNR 311
           +NL YL L    +R +     + +  L  L LS N L  +   +F  L +L  L + +++
Sbjct: 197 SNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ 254

Query: 312 IISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLR 371
           I  I+ + F+N+  SL  +NL+ NNLT L   +  PL  L  +  + NPW CNC +L L 
Sbjct: 255 IQVIERNAFDNL-QSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS 313

Query: 372 DW---LASSAITLNIYCQNPPSMRGR 394
            W   +A S       C  PP+++GR
Sbjct: 314 WWIKDMAPSNTACCARCNTPPNLKGR 339


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  132 bits (333), Expect = 7e-31
 Identities = 88/267 (32%), Positives = 137/267 (51%), Gaps = 7/267 (2%)

Query: 132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191
           +N R L LQ N +  +    F  L  ++ L L +N +  +  G F G+ +L  L+L +N 
Sbjct: 86  VNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR 145

Query: 192 ILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH-NPIEAIQPFAFKG 250
           +  +    F++L  L  L+L +N +  +PS AF  + SLRRL L     +E I   AF+G
Sbjct: 146 LTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEG 205

Query: 251 LANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRN 310
           L NL YL L    ++++     + +  L+ L LS N L+ +   +F  L +L  L L   
Sbjct: 206 LVNLRYLNLGMCNLKDI--PNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA 263

Query: 311 RIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGL 370
           ++ +I+ + F+++  SL+ LNLS NNL +L   +  PL  L  +  N NPW CNC +L L
Sbjct: 264 QVATIERNAFDDL-KSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL 322

Query: 371 RDWL---ASSAITLNIYCQNPPSMRGR 394
             WL     S  T    C  P  ++GR
Sbjct: 323 SWWLKETVPSNTTCCARCHAPAGLKGR 349



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 73/258 (28%), Positives = 116/258 (44%), Gaps = 30/258 (11%)

Query: 32  CSSVCQLCTGR--QINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESEL--------- 80
           C   C  C+ +  ++ C    L+ +P + P +T +L L  N I  I              
Sbjct: 57  CPVACS-CSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEIL 115

Query: 81  ---------------TGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDP 125
                           GL SL  L L ++ +  V  +AF  L  L  L+L NN I+ +  
Sbjct: 116 QLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPS 175

Query: 126 GIFKGLLNLRNLYL-QYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
             F  + +LR L L +  ++ ++    F  LV+++YLNL    L  + + T   +V L  
Sbjct: 176 YAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLT--ALVRLEE 233

Query: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
           L+LS N +  I    FQ L +L  L+L    +  +  NAF+ LKSL  L+LSHN + ++ 
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293

Query: 245 PFAFKGLANLEYLLLKNS 262
              F  L  LE + L ++
Sbjct: 294 HDLFTPLHRLERVHLNHN 311



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFN 335
           N    +I +  DL  + +   S+  N  YL L  N I  I  DTF+++   L+IL LS N
Sbjct: 65  NQASRVICTRRDLAEVPA---SIPVNTRYLNLQENGIQVIRTDTFKHL-RHLEILQLSKN 120

Query: 336 NLTALHPRVLKPLSSLIHLQANSN-----PWECNCKLLGLRD-WLASSAI-TLNIYCQN- 387
            +  +       L SL  L+   N     P +    L  LR+ WL ++ I ++  Y  N 
Sbjct: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180

Query: 388 PPSMR 392
            PS+R
Sbjct: 181 VPSLR 185


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  130 bits (328), Expect = 3e-30
 Identities = 103/375 (27%), Positives = 159/375 (42%), Gaps = 56/375 (14%)

Query: 27  KEILGCSSVCQLCT--GRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLH 84
           + +  C   C +C    R  +C   GL ++P+ FP  T  L L  N+   +  +   GL 
Sbjct: 391 RAVAPCPRAC-VCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLG 449

Query: 85  SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQV 144
            LV+L+L +  I  +   A   L  L +L+L++N +  L     +G   L  LYL+ N+ 
Sbjct: 450 HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRF 509

Query: 145 SFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLE 204
             VP      L S+  L+LQ N +  L  G      ALR + LS N I  +S        
Sbjct: 510 LQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAR 569

Query: 205 NLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA-NLEYLLLKNSR 263
            L  L+L  N L +VP+ A E L +L  L LS NP+ A++  AF+ +  +L++L L +S 
Sbjct: 570 ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSG 629

Query: 264 IRNVTRDGFSGIN-NLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN 322
           +  +    FSG+   L+ L L  N L  L +                             
Sbjct: 630 LEQICPGAFSGLGPGLQSLHLQKNQLRALPA----------------------------- 660

Query: 323 MGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLN 382
                                 L  LS L  +  +SNP+ C+C+LL L  WL    + + 
Sbjct: 661 ----------------------LPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG 698

Query: 383 IYCQNPPSMRGRALR 397
             C  PP+ RG+ ++
Sbjct: 699 ATCATPPNARGQRVK 713



 Score =  115 bits (288), Expect = 1e-25
 Identities = 89/284 (31%), Positives = 129/284 (45%), Gaps = 3/284 (1%)

Query: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
           L L  N +K +    F+G+ +L +L L++ +V  V  G F  L  +  LNL  N L  L 
Sbjct: 67  LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELP 126

Query: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
                G+ +LR L+L  N +  +    F  L  LA L L  N L  +P+ AF+ L  +R 
Sbjct: 127 QEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186

Query: 233 LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLN 292
           L LSHN +  + P A  GL  L  L L ++ ++ +     S    L  L L HN L    
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246

Query: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
            +    L  L  L LD   + ++    F +    L  L+L  N L  L P  L+    L 
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHC-PRLHTLDLRGNQLDTLPP--LQGPGQLR 303

Query: 353 HLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRAL 396
            L+   NP  C C+   L +WLA + +  +  CQ P  +RG AL
Sbjct: 304 RLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEAL 347


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  130 bits (327), Expect = 4e-30
 Identities = 107/398 (26%), Positives = 174/398 (43%), Gaps = 59/398 (14%)

Query: 21  LLLLLHKEIL-----GCSSVCQLCT-GRQINCRNLGLSSIPKNFPESTVFLYLTGNNISY 74
           +LLL+   +L     GC   C+     R + C      ++P+  P  T  L L  N I  
Sbjct: 26  ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85

Query: 75  INESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNL 134
           +N+ E                        F    HL  L LN N +  ++PG F  L NL
Sbjct: 86  LNQDE------------------------FASFPHLEELELNENIVSAVEPGAFNNLFNL 121

Query: 135 RNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR 194
           R L L+ N++  +P GVF  L ++  L++  N++ +L    F  +  L+ L++ +N+++ 
Sbjct: 122 RTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVY 181

Query: 195 ISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANL 254
           IS   F  L +L  L L   NLT +P+ A   L  L  L L H  I AI+ ++FK L  L
Sbjct: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL 241

Query: 255 EYLLLKN-SRIRNVTRDGFSGIN-----------------NLKHLI------LSHNDLEN 290
           + L + +   +  +T +   G+N                  ++HL+      LS+N +  
Sbjct: 242 KVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIST 301

Query: 291 LNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSS 350
           +       L  L  ++L   ++  ++   F  +   L++LN+S N LT L   V   + +
Sbjct: 302 IEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGNQLTTLEESVFHSVGN 360

Query: 351 LIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNP 388
           L  L  +SNP  C+C+LL    W+      LN   Q P
Sbjct: 361 LETLILDSNPLACDCRLL----WVFRRRWRLNFNRQQP 394


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  130 bits (326), Expect = 5e-30
 Identities = 104/388 (26%), Positives = 182/388 (46%), Gaps = 60/388 (15%)

Query: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINES-----ELTGLH-------------- 84
           ++C +LGL + P   P +T  L L  NNI+ I  S      LTGL               
Sbjct: 53  VDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINV 112

Query: 85  ----SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQ 140
                L+++YL+ + +  +  K   +L +L  L++N+N +  + PG F GL NL  L+  
Sbjct: 113 KKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLH-- 170

Query: 141 YNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGF 200
                                 L  NRL ++ S  F  +  L IL +  N I+RI +  F
Sbjct: 171 ----------------------LNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208

Query: 201 QHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLK 260
           + L NL  L +   NLT++P NA   L++L  +S   N +  +   A + + NL++L L 
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 261 NSRIRNVTRDGFSGINNLKHL-ILSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISIDND 318
            + I  + R  FS + +LK L I +  +L +++S     L +L  ++   N R+  I  +
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPN 328

Query: 319 TFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSA 378
            F  +   L+ L L+ N L+AL+   ++ L +L  +  +SNP  C+C +     W+  + 
Sbjct: 329 AFFRL-PKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI----RWMNMNK 383

Query: 379 ITL------NIYCQNPPSMRGRALRYIN 400
             +      +++C +PP  +G+ +R ++
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVH 411


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  130 bits (326), Expect = 5e-30
 Identities = 104/388 (26%), Positives = 182/388 (46%), Gaps = 60/388 (15%)

Query: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINES-----ELTGLH-------------- 84
           ++C +LGL + P   P +T  L L  NNI+ I  S      LTGL               
Sbjct: 53  VDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINV 112

Query: 85  ----SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQ 140
                L+++YL+ + +  +  K   +L +L  L++N+N +  + PG F GL NL  L+  
Sbjct: 113 KKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLH-- 170

Query: 141 YNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGF 200
                                 L  NRL ++ S  F  +  L IL +  N I+RI +  F
Sbjct: 171 ----------------------LNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208

Query: 201 QHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLK 260
           + L NL  L +   NLT++P NA   L++L  +S   N +  +   A + + NL++L L 
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 261 NSRIRNVTRDGFSGINNLKHL-ILSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISIDND 318
            + I  + R  FS + +LK L I +  +L +++S     L +L  ++   N R+  I  +
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPN 328

Query: 319 TFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSA 378
            F  +   L+ L L+ N L+AL+   ++ L +L  +  +SNP  C+C +     W+  + 
Sbjct: 329 AFFRL-PKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI----RWMNMNK 383

Query: 379 ITL------NIYCQNPPSMRGRALRYIN 400
             +      +++C +PP  +G+ +R ++
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVH 411


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score =  130 bits (326), Expect = 5e-30
 Identities = 104/388 (26%), Positives = 182/388 (46%), Gaps = 60/388 (15%)

Query: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINES-----ELTGLH-------------- 84
           ++C +LGL + P   P +T  L L  NNI+ I  S      LTGL               
Sbjct: 53  VDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINV 112

Query: 85  ----SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQ 140
                L+++YL+ + +  +  K   +L +L  L++N+N +  + PG F GL NL  L+  
Sbjct: 113 KKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLH-- 170

Query: 141 YNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGF 200
                                 L  NRL ++ S  F  +  L IL +  N I+RI +  F
Sbjct: 171 ----------------------LNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208

Query: 201 QHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLK 260
           + L NL  L +   NLT++P NA   L++L  +S   N +  +   A + + NL++L L 
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 261 NSRIRNVTRDGFSGINNLKHL-ILSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISIDND 318
            + I  + R  FS + +LK L I +  +L +++S     L +L  ++   N R+  I  +
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPN 328

Query: 319 TFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSA 378
            F  +   L+ L L+ N L+AL+   ++ L +L  +  +SNP  C+C +     W+  + 
Sbjct: 329 AFFRL-PKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI----RWMNMNK 383

Query: 379 ITL------NIYCQNPPSMRGRALRYIN 400
             +      +++C +PP  +G+ +R ++
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVH 411


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  128 bits (321), Expect = 2e-29
 Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 13/364 (3%)

Query: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
           ++C +L L+++P   P  T  L L  N+I  +++SEL  L +L  L L  ++        
Sbjct: 53  VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112

Query: 104 FVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNL 163
           F  L  L  L L  N + RL+   F GL +L+ LYL +NQ+  +    F+ L ++  L+L
Sbjct: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172

Query: 164 QRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA 223
             N L  + S  F  +  L IL +  N +  I +  F+ L NL  L L   NL ++   A
Sbjct: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232

Query: 224 FEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLIL 283
            E L+SL  LS   N +  +   A + +  L++L L  + ++ V    F+ + +LK L L
Sbjct: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292

Query: 284 SHNDLENLNS-DTFSL--LKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340
             N++E L S D F+L  L  L  L +  N  +S  +    +    ++ L L+ N L+AL
Sbjct: 293 --NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSAL 350

Query: 341 HPRVLKPLSSLIHLQANSNPWECNCKL-----LGLRDWLASSAITLNIYCQNPPSMRGRA 395
           H + ++ L +L  +  + NP  C+C +      G R        TL   C  PP ++   
Sbjct: 351 HQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL---CAEPPDLQRLP 407

Query: 396 LRYI 399
           +R +
Sbjct: 408 VREV 411


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  128 bits (321), Expect = 2e-29
 Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 13/364 (3%)

Query: 44  INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
           ++C +L L+++P   P  T  L L  N+I  +++SEL  L +L  L L  ++        
Sbjct: 53  VDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCD 112

Query: 104 FVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNL 163
           F  L  L  L L  N + RL+   F GL +L+ LYL +NQ+  +    F+ L ++  L+L
Sbjct: 113 FHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHL 172

Query: 164 QRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA 223
             N L  + S  F  +  L IL +  N +  I +  F+ L NL  L L   NL ++   A
Sbjct: 173 NSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA 232

Query: 224 FEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLIL 283
            E L+SL  LS   N +  +   A + +  L++L L  + ++ V    F+ + +LK L L
Sbjct: 233 LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGL 292

Query: 284 SHNDLENLNS-DTFSL--LKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340
             N++E L S D F+L  L  L  L +  N  +S  +    +    ++ L L+ N L+AL
Sbjct: 293 --NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSAL 350

Query: 341 HPRVLKPLSSLIHLQANSNPWECNCKL-----LGLRDWLASSAITLNIYCQNPPSMRGRA 395
           H + ++ L +L  +  + NP  C+C +      G R        TL   C  PP ++   
Sbjct: 351 HQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL---CAEPPDLQRLP 407

Query: 396 LRYI 399
           +R +
Sbjct: 408 VREV 411


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score =  127 bits (319), Expect = 3e-29
 Identities = 119/393 (30%), Positives = 171/393 (43%), Gaps = 71/393 (18%)

Query: 19  CYLLLLLHKEILG---CSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYI 75
           CY L+    E++    C SVC+ C    I C + GL+SIP + P+               
Sbjct: 38  CYGLIAFLTEVIDSTTCPSVCR-CDNGFIYCNDRGLTSIPADIPDDAT------------ 84

Query: 76  NESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLR 135
                        LYL N+ I                   NN  I    P   K  +N++
Sbjct: 85  ------------TLYLQNNQI-------------------NNAGI----PQDLKTKVNVQ 109

Query: 136 NLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRI 195
            +YL  N +   P    N   S++ L+LQ N +  +   +   +  L  L L +N++  +
Sbjct: 110 VIYLYENDLDEFP---INLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTV 166

Query: 196 S--ESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLAN 253
           S  E  F   + L  L+L  N+L+ +PS     L+ LR   L  N I  I   AFKGL +
Sbjct: 167 SIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR---LDDNRISTIPLHAFKGLNS 223

Query: 254 LEYLLLKNSRIRN--VTRDGFSGINNLKHLILSHNDLEN--LNSDTFSLLKNLIYLKLDR 309
           L  L+L  + + N  +  D FS + NL  L L  N L    LN  +  L K    L L  
Sbjct: 224 LRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQK----LYLQD 279

Query: 310 NRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLG 369
           N I  I  +T   M   L+ L+LS NNLT L   +   L +L  L   +NPW C C L+ 
Sbjct: 280 NAISHIPYNTLAKM-RELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMW 338

Query: 370 LRDWLASSAITLNI---YCQNPPSMRGRALRYI 399
           LRDW+ + A  +N+    CQ P  +RG A++ I
Sbjct: 339 LRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDI 371


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  126 bits (316), Expect = 7e-29
 Identities = 107/371 (28%), Positives = 156/371 (42%), Gaps = 82/371 (22%)

Query: 32  CSSVCQLCTGR--QINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVAL 89
           C SVC  C+ +  ++ C   GLS +P+  P +T +L L  NNI  I       LH     
Sbjct: 46  CPSVCS-CSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLH----- 99

Query: 90  YLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPR 149
                              HL  L L  N I++++ G F GL +L  L L  N ++ +P 
Sbjct: 100 -------------------HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPS 140

Query: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR-ISESGFQHLENLAC 208
           G F  L  ++ L L+ N +  + S  F  + +L  LDL     L  ISE  F+ L NL  
Sbjct: 141 GAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKY 200

Query: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
           L LG  N+  +P+     L  L  L +S N    I+P +F GL++L+ L + NS++  + 
Sbjct: 201 LNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIE 258

Query: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
           R+ F G+ +L  L L+HN+L +L  D F+ L+ L+ L L  N                  
Sbjct: 259 RNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN------------------ 300

Query: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNI---YC 385
                                          PW C+C +L L  WL     T +     C
Sbjct: 301 -------------------------------PWNCDCDILWLAWWLREYIPTNSTCCGRC 329

Query: 386 QNPPSMRGRAL 396
             P  MRGR L
Sbjct: 330 HAPMHMRGRYL 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,519,752
Number of Sequences: 37866
Number of extensions: 906574
Number of successful extensions: 5295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 2103
Number of HSP's gapped (non-prelim): 1209
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.