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Search of human proteins with 19743803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19743803 fibulin 5 precursor [Homo sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19743803 fibulin 5 precursor [Homo sapiens] 980 0.0
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 494 e-140
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 416 e-116
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 416 e-116
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 416 e-116
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 274 1e-73
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 262 5e-70
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 262 5e-70
gi|34734066 fibulin 1 isoform D [Homo sapiens] 249 5e-66
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 232 6e-61
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 232 6e-61
gi|46249414 latent transforming growth factor beta binding prote... 193 3e-49
gi|46249412 latent transforming growth factor beta binding prote... 193 3e-49
gi|66346695 fibrillin 2 precursor [Homo sapiens] 184 2e-46
gi|24430141 fibrillin 1 precursor [Homo sapiens] 183 2e-46
gi|56237021 fibrillin 3 precursor [Homo sapiens] 181 9e-46
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 179 5e-45
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 179 5e-45
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 179 5e-45
gi|194328809 latent transforming growth factor beta binding prot... 176 3e-44
gi|18497288 latent transforming growth factor beta binding prote... 176 3e-44
gi|118572606 hemicentin 1 [Homo sapiens] 176 5e-44
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 171 1e-42
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 171 1e-42
gi|110347437 latent transforming growth factor beta binding prot... 170 2e-42
gi|110347412 latent transforming growth factor beta binding prot... 170 2e-42
gi|110347431 latent transforming growth factor beta binding prot... 170 2e-42
gi|4557733 latent transforming growth factor beta binding protei... 166 3e-41
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 158 1e-38
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 157 2e-38
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 980 bits (2533), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV
Sbjct: 1 MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
Query: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD 120
NQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD
Sbjct: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD 120
Query: 121 ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL 180
ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL
Sbjct: 121 ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL 180
Query: 181 CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE 240
CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE
Sbjct: 181 CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE 240
Query: 241 DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCN 300
DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCN
Sbjct: 241 DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCN 300
Query: 301 LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRS 360
LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRS
Sbjct: 301 LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRS 360
Query: 361 VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL 420
VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL
Sbjct: 361 VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL 420
Query: 421 EMITVNTVINFRGSSVIRLRIYVSQYPF 448
EMITVNTVINFRGSSVIRLRIYVSQYPF
Sbjct: 421 EMITVNTVINFRGSSVIRLRIYVSQYPF 448
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 494 bits (1273), Expect = e-140
Identities = 226/453 (49%), Positives = 300/453 (66%), Gaps = 22/453 (4%)
Query: 1 MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRG 55
+PG + + +L L SP +++ +CT+G++ D S C D++EC TIPEAC+G
Sbjct: 8 LPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKG 67
Query: 56 DMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRF 115
+M C+N GGYLC+PR+ V + GP P PP PN C
Sbjct: 68 EMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPPAQHPNP--------CPP 111
Query: 116 GYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG 175
GY+ D+ + CVDVDECA H C P+Q C N G Y C+C DGY + +C+DIDECRY
Sbjct: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR 171
Query: 176 YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPG 235
YCQ C N+PGS+ C C PGF L + RSC DVNEC PC Q C N+YG+F+CRC G
Sbjct: 172 YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQG 231
Query: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
YEL DG CSD+DECS+S +LCQ+ CVN+PG + C CP GY LL R CQDI+ECE
Sbjct: 232 YELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRLCQDIDECESG 290
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDV 355
H C+ QTC N GG++C+D RC EPY+++S+NRC+CPA NP CR+QP +I++R M +
Sbjct: 291 AHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI 350
Query: 356 VSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRE 415
S RSVPAD+FQ+QAT+ YPGAY FQI++GN +FY+RQ +SA LV+ RP+ GPRE
Sbjct: 351 TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPRE 410
Query: 416 IQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF 448
LDLEM+T+N+++++R SSV+RL ++V Y F
Sbjct: 411 YVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF 443
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 416 bits (1068), Expect = e-116
Identities = 205/493 (41%), Positives = 278/493 (56%), Gaps = 52/493 (10%)
Query: 6 RILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
+ L +T+L L L + + QCT+G++ D QC DIDEC +P+AC+G M CV
Sbjct: 3 KALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCV 62
Query: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYS------------------------GPYPAAA 96
N GGYLC+P+T + T + G + A+A
Sbjct: 63 NHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA 122
Query: 97 PPLSAPNYPT--------------------ISRPLICRFGYQMDESNQCVDVDECATDSH 136
++ P T S + C GY+ E N C D+DEC +H
Sbjct: 123 AAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTH 182
Query: 137 QCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSCTCNPG 195
C Q+CIN G + C C GY QC+DIDEC YC Q C N PGS+ C C+PG
Sbjct: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPG 242
Query: 196 FTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSE 255
F L + +C D+NEC N C Q C N GSFIC+C+ GYEL D ++C D+DEC S
Sbjct: 243 FQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
Query: 256 FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
+LCQ++CVN+PG + C CP GY ++ +R+CQDINECE N C + C+N GGF+C
Sbjct: 303 YLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHGGFRCY 360
Query: 316 DPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP 375
C++PY+ +NRC+CP N CR+ P +I+Y+ M + S RSVP+DIFQ+QATT Y
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 376 GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSS 435
F+IKSGNE EFY+RQT P+SA LV+ + + GPRE +DLEM+TV+++ FR SS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 436 VIRLRIYVSQYPF 448
V+RL I V + F
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 416 bits (1068), Expect = e-116
Identities = 205/493 (41%), Positives = 278/493 (56%), Gaps = 52/493 (10%)
Query: 6 RILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
+ L +T+L L L + + QCT+G++ D QC DIDEC +P+AC+G M CV
Sbjct: 3 KALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCV 62
Query: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYS------------------------GPYPAAA 96
N GGYLC+P+T + T + G + A+A
Sbjct: 63 NHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA 122
Query: 97 PPLSAPNYPT--------------------ISRPLICRFGYQMDESNQCVDVDECATDSH 136
++ P T S + C GY+ E N C D+DEC +H
Sbjct: 123 AAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTH 182
Query: 137 QCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSCTCNPG 195
C Q+CIN G + C C GY QC+DIDEC YC Q C N PGS+ C C+PG
Sbjct: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPG 242
Query: 196 FTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSE 255
F L + +C D+NEC N C Q C N GSFIC+C+ GYEL D ++C D+DEC S
Sbjct: 243 FQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
Query: 256 FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
+LCQ++CVN+PG + C CP GY ++ +R+CQDINECE N C + C+N GGF+C
Sbjct: 303 YLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHGGFRCY 360
Query: 316 DPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP 375
C++PY+ +NRC+CP N CR+ P +I+Y+ M + S RSVP+DIFQ+QATT Y
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 376 GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSS 435
F+IKSGNE EFY+RQT P+SA LV+ + + GPRE +DLEM+TV+++ FR SS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 436 VIRLRIYVSQYPF 448
V+RL I V + F
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 416 bits (1068), Expect = e-116
Identities = 205/493 (41%), Positives = 278/493 (56%), Gaps = 52/493 (10%)
Query: 6 RILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
+ L +T+L L L + + QCT+G++ D QC DIDEC +P+AC+G M CV
Sbjct: 3 KALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCV 62
Query: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYS------------------------GPYPAAA 96
N GGYLC+P+T + T + G + A+A
Sbjct: 63 NHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA 122
Query: 97 PPLSAPNYPT--------------------ISRPLICRFGYQMDESNQCVDVDECATDSH 136
++ P T S + C GY+ E N C D+DEC +H
Sbjct: 123 AAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTH 182
Query: 137 QCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSCTCNPG 195
C Q+CIN G + C C GY QC+DIDEC YC Q C N PGS+ C C+PG
Sbjct: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPG 242
Query: 196 FTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSE 255
F L + +C D+NEC N C Q C N GSFIC+C+ GYEL D ++C D+DEC S
Sbjct: 243 FQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
Query: 256 FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
+LCQ++CVN+PG + C CP GY ++ +R+CQDINECE N C + C+N GGF+C
Sbjct: 303 YLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHGGFRCY 360
Query: 316 DPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP 375
C++PY+ +NRC+CP N CR+ P +I+Y+ M + S RSVP+DIFQ+QATT Y
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 376 GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSS 435
F+IKSGNE EFY+RQT P+SA LV+ + + GPRE +DLEM+TV+++ FR SS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 436 VIRLRIYVSQYPF 448
V+RL I V + F
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 274 bits (701), Expect = 1e-73
Identities = 160/455 (35%), Positives = 237/455 (52%), Gaps = 33/455 (7%)
Query: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
C+ + G+ + Q C G++L + C DIDEC + C D +C N G + C P+
Sbjct: 233 CINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 72 T---NPVYRGPYSNPYST----PYSGPYPAAAPPLSAPNYPTISRPLI-CRFGYQM-DES 122
+ + N S P P ++ T + + C GY + +E
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YC 177
+CVDVDECA + C C+N+ G + C C GY+ + C+D++EC RY C
Sbjct: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYE 237
C N GSY C+C+ GF L+ DGRSC+D+NEC++ +PC Q C N YGS+ C C GY+
Sbjct: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQ 470
Query: 238 LEE-DGVHCSDMDECSFSE--FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECE 293
L + DGV C D+DEC+ +C + C+N PG++ CSCP GY L + R+CQDI+EC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC--MCPAENPGCRDQPFTILYR 351
H C++ +TC+N+QGGF+C+ C E Y R + RC + EN C P I Y
Sbjct: 531 TGIHNCSINETCFNIQGGFRCL-AFECPENYRRSAATRCERLPCHENRECSKLPLRITYY 589
Query: 352 DMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIK 411
+ + PA +F+M ++ PG I GNE F R+ P S + +T+P+
Sbjct: 590 HLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVP 649
Query: 412 GPREIQLDLEM--ITVNTVINFRGSSVIRLRIYVS 444
PR++ L ++M TV +F V +L I+VS
Sbjct: 650 EPRDLLLTVKMDLSRHGTVSSF----VAKLFIFVS 680
Score = 148 bits (374), Expect = 9e-36
Identities = 98/285 (34%), Positives = 125/285 (43%), Gaps = 79/285 (27%)
Query: 113 CRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTC----SCTDGYWLLE-GQC 166
C GYQ+ + C DV+EC T SH C + CINT G + C SC GY L E C
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 167 LDIDECRYG--------YCQ---------------------------------------- 178
DIDEC G CQ
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP 320
Query: 179 --QLCANVPGSYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSF 228
C N GSY+C C G+ LNE+G C DV+ECA PC + CVN+ GSF
Sbjct: 321 IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSF 380
Query: 229 ICRCDPGYELEEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQ 287
C C GY + C D++EC + LC H+C N G+Y CSC G+ L D RSC+
Sbjct: 381 RCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE 440
Query: 288 DINECEHRNHTCNLQQTCYNLQGGFKC----------IDPIRCEE 322
DINEC + C+ Q C N+ G ++C +D + CE+
Sbjct: 441 DINECS--SSPCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Score = 105 bits (262), Expect = 8e-23
Identities = 78/270 (28%), Positives = 113/270 (41%), Gaps = 77/270 (28%)
Query: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169
+ E+++ ++V+E D + +C Q C +T CSC GY LL C D+
Sbjct: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
Query: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE------- 214
+EC G C+ + C N GS+ C +C G+ L ED SC+D++EC +
Sbjct: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
Query: 215 ---------------------------------NPCV---------QTCVNTYGSFICR- 231
N C+ TC+NT GS+ C+
Sbjct: 277 FICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK 336
Query: 232 ----CDPGYELEEDGVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDDNRS 285
C GY L E+G C D+DEC+ C H CVN PG++ C C GY +R
Sbjct: 337 NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396
Query: 286 CQDINECE-HRNHTCNLQQTCYNLQGGFKC 314
C D+NEC+ + C C N G + C
Sbjct: 397 CVDVNECQRYPGRLCG--HKCENTLGSYLC 424
Score = 94.4 bits (233), Expect = 2e-19
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266
+ C PC Q C +T +C C GY+L DGV C D++EC C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322
G++ C SC GY L +DN SC+DI+ECE H C C N G F+C ++C+
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 PYLRISDNRCM 333
+++ + C+
Sbjct: 297 GFIQDALGNCI 307
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 262 bits (669), Expect = 5e-70
Identities = 144/422 (34%), Positives = 207/422 (49%), Gaps = 55/422 (13%)
Query: 15 LCLPSPGN----AQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIP 70
LC + G+ A+ +C +GF L G C+DI+EC ++ E CR C+N G Y C
Sbjct: 780 LCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQ- 837
Query: 71 RTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVD 129
PLIC GY D+ +CVDV+
Sbjct: 838 -------------------------------------RNPLICARGYHASDDGTKCVDVN 860
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLEGQCLDIDECRYG---YCQQLCANV 184
EC T H+C Q+C N G Y C C G+ C+D++EC CQ C N
Sbjct: 861 ECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENT 920
Query: 185 PGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVH 244
GSY C+C GF L DG+ C+DVNEC + C Q C N YGS+ C C GY+L EDG
Sbjct: 921 LGSYRCSCASGFLLAADGKRCEDVNECEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHT 979
Query: 245 CSDMDECSFSE-FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECEHRNHTCNLQ 302
C+D+DEC+ LC C+N PG+Y C+CP GY + + RSC+D++EC H C+
Sbjct: 980 CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1039
Query: 303 QTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPA--ENPGCRDQPFTILYRDMDVVSGRS 360
+TC+N+QG F+C+ C Y+++S +C + C++ P I + ++ +G
Sbjct: 1040 ETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLL 1098
Query: 361 VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL 420
VPA IF++ + G I GNE F R+ + + + R + PR+ LD+
Sbjct: 1099 VPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDV 1158
Query: 421 EM 422
EM
Sbjct: 1159 EM 1160
Score = 152 bits (385), Expect = 5e-37
Identities = 115/383 (30%), Positives = 156/383 (40%), Gaps = 105/383 (27%)
Query: 42 DIDECRTIP-EACRGDMMCVNQNGGYLCI---------------PRTNPVY-RGPYSNPY 84
D DEC +P E C+ +C+N G Y C P +P P
Sbjct: 604 DQDECLLLPGELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661
Query: 85 STPYSG------PYPAAAPPLSAPNYP------TISRPLICRF--GYQ-MDESNQCVDVD 129
+ +S P P P N P T+ IC GY M + C D++
Sbjct: 662 KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDIN 721
Query: 130 ECATDSHQCNPTQICINTEGGYTC----SCTDGYWLLEGQCLDIDECRYG---------- 175
EC TD H C+ + C+NT G + C +C GY L +G+C D+DEC G
Sbjct: 722 ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLC 781
Query: 176 -------YCQQ---------------------------------LCANVPGSYSCTCNP- 194
YCQ C N GSY+C NP
Sbjct: 782 QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841
Query: 195 ----GFTLNEDGRSCQDVNECAT-ENPC--VQTCVNTYGSFICRCDPGYELEEDGVHCSD 247
G+ ++DG C DVNEC T + C Q C N GS+ C C G++ + G C D
Sbjct: 842 ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 901
Query: 248 MDECSFSE-FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
++EC S LCQH C N G+Y CSC G++L D + C+D+NECE + Q C
Sbjct: 902 VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECA 957
Query: 307 NLQGGFKCIDPIRCEEPYLRISD 329
N+ G ++C C + Y D
Sbjct: 958 NIYGSYQCY----CRQGYQLAED 976
Score = 128 bits (321), Expect = 1e-29
Identities = 74/221 (33%), Positives = 95/221 (42%), Gaps = 48/221 (21%)
Query: 168 DIDECRY---GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQ------------------ 206
D DEC CQ LC N GSY C C PGF+L +DGR+C+
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 207 ---------------DVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDEC 251
N C PC Q C GS IC C PGY + DGV C D++EC
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINEC 723
Query: 252 SFSEFLCQ--HECVNQPGTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
C CVN G++ C +C PGY L D C+D++EC HTC C
Sbjct: 724 VTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLC 781
Query: 306 YNLQGGFKCIDPIRCEEPYLRISDNRCM----CPAENPGCR 342
N +G F C RC + +L+ + C+ C + + CR
Sbjct: 782 QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCR 822
Score = 121 bits (304), Expect = 1e-27
Identities = 91/295 (30%), Positives = 129/295 (43%), Gaps = 57/295 (19%)
Query: 91 PYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECAT-DSHQCNPTQICINTEG 149
P PAAAP + L ++ S D DEC C +CINT G
Sbjct: 568 PEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQ--HLCINTVG 625
Query: 150 GYTCSCTDGYWL-----------------------LEGQCLDI------------DECR- 173
Y C+C G+ L L+ + + + C+
Sbjct: 626 SYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD 685
Query: 174 YGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATE-NPCV--QTCVNTYGSFIC 230
G C+Q+C+ V GS C+C PG+ + DG SC+D+NEC T+ + C + CVNT GSF C
Sbjct: 686 NGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHC 745
Query: 231 ----RCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQPGTYFCS----CPPGYILL 280
C+PGY L++ C D+DEC+ CQ C N G+++C C G+ L
Sbjct: 746 YKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQ 802
Query: 281 DDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC-IDPIRCEEPYLRISDNRCMC 334
D +C DINEC + C +C N G + C +P+ C Y SD+ C
Sbjct: 803 DPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGY-HASDDGTKC 856
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 262 bits (669), Expect = 5e-70
Identities = 144/422 (34%), Positives = 207/422 (49%), Gaps = 55/422 (13%)
Query: 15 LCLPSPGN----AQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIP 70
LC + G+ A+ +C +GF L G C+DI+EC ++ E CR C+N G Y C
Sbjct: 827 LCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQ- 884
Query: 71 RTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVD 129
PLIC GY D+ +CVDV+
Sbjct: 885 -------------------------------------RNPLICARGYHASDDGTKCVDVN 907
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLEGQCLDIDECRYG---YCQQLCANV 184
EC T H+C Q+C N G Y C C G+ C+D++EC CQ C N
Sbjct: 908 ECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENT 967
Query: 185 PGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVH 244
GSY C+C GF L DG+ C+DVNEC + C Q C N YGS+ C C GY+L EDG
Sbjct: 968 LGSYRCSCASGFLLAADGKRCEDVNECEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHT 1026
Query: 245 CSDMDECSFSE-FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECEHRNHTCNLQ 302
C+D+DEC+ LC C+N PG+Y C+CP GY + + RSC+D++EC H C+
Sbjct: 1027 CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1086
Query: 303 QTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPA--ENPGCRDQPFTILYRDMDVVSGRS 360
+TC+N+QG F+C+ C Y+++S +C + C++ P I + ++ +G
Sbjct: 1087 ETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLL 1145
Query: 361 VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL 420
VPA IF++ + G I GNE F R+ + + + R + PR+ LD+
Sbjct: 1146 VPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDV 1205
Query: 421 EM 422
EM
Sbjct: 1206 EM 1207
Score = 167 bits (422), Expect = 2e-41
Identities = 109/378 (28%), Positives = 152/378 (40%), Gaps = 109/378 (28%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C G+A C G+ + C D DEC C CVN G + C+ T
Sbjct: 692 VCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHT-- 749
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
++C GY ++ +CVD++EC TD
Sbjct: 750 ------------------------------------VLCADGYILNAHRKCVDINECVTD 773
Query: 135 SHQCNPTQICINTEGGYTC----SCTDGYWLLEGQCLDIDECRYG--------------- 175
H C+ + C+NT G + C +C GY L +G+C D+DEC G
Sbjct: 774 LHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKG 833
Query: 176 --YCQQ---------------------------------LCANVPGSYSCTCNP-----G 195
YCQ C N GSY+C NP G
Sbjct: 834 SFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARG 893
Query: 196 FTLNEDGRSCQDVNECAT-ENPC--VQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECS 252
+ ++DG C DVNEC T + C Q C N GS+ C C G++ + G C D++EC
Sbjct: 894 YHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECW 953
Query: 253 FSE-FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGG 311
S LCQH C N G+Y CSC G++L D + C+D+NECE + Q C N+ G
Sbjct: 954 ASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGS 1009
Query: 312 FKCIDPIRCEEPYLRISD 329
++C C + Y D
Sbjct: 1010 YQCY----CRQGYQLAED 1023
Score = 144 bits (362), Expect = 2e-34
Identities = 110/333 (33%), Positives = 146/333 (43%), Gaps = 65/333 (19%)
Query: 42 DIDECRTIP-EACRGDMMCVNQNGGYLCI---------------PRTNPVY-RGPYSNPY 84
D DEC +P E C+ +C+N G Y C P +P P
Sbjct: 604 DQDECLLLPGELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661
Query: 85 STPYSG------PYPAAAPPLSAPNYP------TISRPLICRF--GYQ-MDESNQCVDVD 129
+ +S P P P N P T+ IC GY M + C D D
Sbjct: 662 KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQD 721
Query: 130 ECATDSHQCNPTQICINTEGGYTC-----SCTDGYWL-LEGQCLDIDEC--RYGYCQ--Q 179
EC +H C+ Q C+NT G + C C DGY L +C+DI+EC C +
Sbjct: 722 ECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGE 781
Query: 180 LCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATENPCVQ---TCVNTYGSFIC-- 230
C N GS+ C TC PG+ L +DG C+DV+ECA Q C NT GSF C
Sbjct: 782 HCVNTLGSFHCYKALTCEPGYAL-KDG-ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQA 839
Query: 231 --RCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQPGTYFCS-----CPPGYILLD 281
RC G+ + +G +C D++EC+ C+ C+N G+Y C C GY D
Sbjct: 840 RQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASD 898
Query: 282 DNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
D C D+NECE H C Q C+NL G ++C
Sbjct: 899 DGTKCVDVNECETGVHRCGEGQVCHNLPGSYRC 931
Score = 130 bits (327), Expect = 2e-30
Identities = 75/208 (36%), Positives = 89/208 (42%), Gaps = 45/208 (21%)
Query: 168 DIDECRY---GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQ------------------ 206
D DEC CQ LC N GSY C C PGF+L +DGR+C+
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 207 ---------------DVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDEC 251
N C PC Q C GS IC C PGY + DGV C D DEC
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDEC 723
Query: 252 SFSEFLCQHE--CVNQPGTYFC-----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 304
C CVN G+++C C GYI L+ +R C DINEC HTC+ +
Sbjct: 724 LMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYI-LNAHRKCVDINECVTDLHTCSRGEH 782
Query: 305 CYNLQGGFKCIDPIRCEEPYLRISDNRC 332
C N G F C + CE Y + D C
Sbjct: 783 CVNTLGSFHCYKALTCEPGY-ALKDGEC 809
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 249 bits (635), Expect = 5e-66
Identities = 163/483 (33%), Positives = 239/483 (49%), Gaps = 62/483 (12%)
Query: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
C+ + G+ + Q C G++L + C DIDEC + C D +C N G + C P+
Sbjct: 233 CINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 72 T---NPVYRGPYSNPYST----PYSGPYPAAAPPLSAPNYPTISRPLI-CRFGYQM-DES 122
+ + N S P P ++ T + + C GY + +E
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YC 177
+CVDVDECA + C C+N+ G + C C GY+ + C+D++EC RY C
Sbjct: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYE 237
C N GSY C+C+ GF L+ DGRSC+D+NEC++ +PC Q C N YGS+ C C GY+
Sbjct: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQ 470
Query: 238 LEE-DGVHCSDMDECSFSE--FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECE 293
L + DGV C D+DEC+ +C + C+N PG++ CSCP GY L + R+CQDI+EC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDN---------RCMCPAENPGCRDQ 344
H C++ +TC+N+QGGF+C+ C E Y R + RC+ CR
Sbjct: 531 TGIHNCSINETCFNIQGGFRCL-AFECPENYRRSAATLQQEKTDTVRCI-----KSCRPN 584
Query: 345 PFTILYRDMDVVSGRSV----------PADIFQMQA-TTRYPG--AYYIFQIKSGNEGRE 391
T ++ + +S + P +I ++A T +P A IF I GN
Sbjct: 585 DVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDS 644
Query: 392 F-----YMRQTGPISATLVMTRPIKGPREIQLDLEM-ITVNTVINFRGSSVIRLRIYVSQ 445
F YM G + RPI GP L LEM V V++ R +V+ + I+VS+
Sbjct: 645 FDIIKRYM--DGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHR--NVVNVHIFVSE 700
Query: 446 YPF 448
Y F
Sbjct: 701 YWF 703
Score = 148 bits (374), Expect = 9e-36
Identities = 98/285 (34%), Positives = 125/285 (43%), Gaps = 79/285 (27%)
Query: 113 CRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTC----SCTDGYWLLE-GQC 166
C GYQ+ + C DV+EC T SH C + CINT G + C SC GY L E C
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 167 LDIDECRYG--------YCQ---------------------------------------- 178
DIDEC G CQ
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP 320
Query: 179 --QLCANVPGSYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSF 228
C N GSY+C C G+ LNE+G C DV+ECA PC + CVN+ GSF
Sbjct: 321 IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSF 380
Query: 229 ICRCDPGYELEEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQ 287
C C GY + C D++EC + LC H+C N G+Y CSC G+ L D RSC+
Sbjct: 381 RCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE 440
Query: 288 DINECEHRNHTCNLQQTCYNLQGGFKC----------IDPIRCEE 322
DINEC + C+ Q C N+ G ++C +D + CE+
Sbjct: 441 DINECS--SSPCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Score = 105 bits (262), Expect = 8e-23
Identities = 78/270 (28%), Positives = 113/270 (41%), Gaps = 77/270 (28%)
Query: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169
+ E+++ ++V+E D + +C Q C +T CSC GY LL C D+
Sbjct: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
Query: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE------- 214
+EC G C+ + C N GS+ C +C G+ L ED SC+D++EC +
Sbjct: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
Query: 215 ---------------------------------NPCV---------QTCVNTYGSFICR- 231
N C+ TC+NT GS+ C+
Sbjct: 277 FICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK 336
Query: 232 ----CDPGYELEEDGVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDDNRS 285
C GY L E+G C D+DEC+ C H CVN PG++ C C GY +R
Sbjct: 337 NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396
Query: 286 CQDINECE-HRNHTCNLQQTCYNLQGGFKC 314
C D+NEC+ + C C N G + C
Sbjct: 397 CVDVNECQRYPGRLCG--HKCENTLGSYLC 424
Score = 94.4 bits (233), Expect = 2e-19
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266
+ C PC Q C +T +C C GY+L DGV C D++EC C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322
G++ C SC GY L +DN SC+DI+ECE H C C N G F+C ++C+
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 PYLRISDNRCM 333
+++ + C+
Sbjct: 297 GFIQDALGNCI 307
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 232 bits (591), Expect = 6e-61
Identities = 124/333 (37%), Positives = 181/333 (54%), Gaps = 25/333 (7%)
Query: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
C+ + G+ + Q C G++L + C DIDEC + C D +C N G + C P+
Sbjct: 233 CINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 72 T---NPVYRGPYSNPYST----PYSGPYPAAAPPLSAPNYPTISRPLI-CRFGYQM-DES 122
+ + N S P P ++ T + + C GY + +E
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YC 177
+CVDVDECA + C C+N+ G + C C GY+ + C+D++EC RY C
Sbjct: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYE 237
C N GSY C+C+ GF L+ DGRSC+D+NEC++ +PC Q C N YGS+ C C GY+
Sbjct: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQ 470
Query: 238 LEE-DGVHCSDMDECSFSE--FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECE 293
L + DGV C D+DEC+ +C + C+N PG++ CSCP GY L + R+CQDI+EC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR 326
H C++ +TC+N+QGGF+C+ C E Y R
Sbjct: 531 TGIHNCSINETCFNIQGGFRCL-AFECPENYRR 562
Score = 148 bits (374), Expect = 9e-36
Identities = 98/285 (34%), Positives = 125/285 (43%), Gaps = 79/285 (27%)
Query: 113 CRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTC----SCTDGYWLLE-GQC 166
C GYQ+ + C DV+EC T SH C + CINT G + C SC GY L E C
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 167 LDIDECRYG--------YCQ---------------------------------------- 178
DIDEC G CQ
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP 320
Query: 179 --QLCANVPGSYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSF 228
C N GSY+C C G+ LNE+G C DV+ECA PC + CVN+ GSF
Sbjct: 321 IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSF 380
Query: 229 ICRCDPGYELEEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQ 287
C C GY + C D++EC + LC H+C N G+Y CSC G+ L D RSC+
Sbjct: 381 RCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE 440
Query: 288 DINECEHRNHTCNLQQTCYNLQGGFKC----------IDPIRCEE 322
DINEC + C+ Q C N+ G ++C +D + CE+
Sbjct: 441 DINECS--SSPCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Score = 105 bits (262), Expect = 8e-23
Identities = 78/270 (28%), Positives = 113/270 (41%), Gaps = 77/270 (28%)
Query: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169
+ E+++ ++V+E D + +C Q C +T CSC GY LL C D+
Sbjct: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
Query: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE------- 214
+EC G C+ + C N GS+ C +C G+ L ED SC+D++EC +
Sbjct: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
Query: 215 ---------------------------------NPCV---------QTCVNTYGSFICR- 231
N C+ TC+NT GS+ C+
Sbjct: 277 FICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK 336
Query: 232 ----CDPGYELEEDGVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDDNRS 285
C GY L E+G C D+DEC+ C H CVN PG++ C C GY +R
Sbjct: 337 NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396
Query: 286 CQDINECE-HRNHTCNLQQTCYNLQGGFKC 314
C D+NEC+ + C C N G + C
Sbjct: 397 CVDVNECQRYPGRLCG--HKCENTLGSYLC 424
Score = 94.4 bits (233), Expect = 2e-19
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266
+ C PC Q C +T +C C GY+L DGV C D++EC C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322
G++ C SC GY L +DN SC+DI+ECE H C C N G F+C ++C+
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 PYLRISDNRCM 333
+++ + C+
Sbjct: 297 GFIQDALGNCI 307
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 232 bits (591), Expect = 6e-61
Identities = 124/333 (37%), Positives = 181/333 (54%), Gaps = 25/333 (7%)
Query: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
C+ + G+ + Q C G++L + C DIDEC + C D +C N G + C P+
Sbjct: 233 CINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 72 T---NPVYRGPYSNPYST----PYSGPYPAAAPPLSAPNYPTISRPLI-CRFGYQM-DES 122
+ + N S P P ++ T + + C GY + +E
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YC 177
+CVDVDECA + C C+N+ G + C C GY+ + C+D++EC RY C
Sbjct: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYE 237
C N GSY C+C+ GF L+ DGRSC+D+NEC++ +PC Q C N YGS+ C C GY+
Sbjct: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQ 470
Query: 238 LEE-DGVHCSDMDECSFSE--FLCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECE 293
L + DGV C D+DEC+ +C + C+N PG++ CSCP GY L + R+CQDI+EC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR 326
H C++ +TC+N+QGGF+C+ C E Y R
Sbjct: 531 TGIHNCSINETCFNIQGGFRCL-AFECPENYRR 562
Score = 148 bits (374), Expect = 9e-36
Identities = 98/285 (34%), Positives = 125/285 (43%), Gaps = 79/285 (27%)
Query: 113 CRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTC----SCTDGYWLLE-GQC 166
C GYQ+ + C DV+EC T SH C + CINT G + C SC GY L E C
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 167 LDIDECRYG--------YCQ---------------------------------------- 178
DIDEC G CQ
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP 320
Query: 179 --QLCANVPGSYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSF 228
C N GSY+C C G+ LNE+G C DV+ECA PC + CVN+ GSF
Sbjct: 321 IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSF 380
Query: 229 ICRCDPGYELEEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQ 287
C C GY + C D++EC + LC H+C N G+Y CSC G+ L D RSC+
Sbjct: 381 RCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE 440
Query: 288 DINECEHRNHTCNLQQTCYNLQGGFKC----------IDPIRCEE 322
DINEC + C+ Q C N+ G ++C +D + CE+
Sbjct: 441 DINECS--SSPCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Score = 105 bits (262), Expect = 8e-23
Identities = 78/270 (28%), Positives = 113/270 (41%), Gaps = 77/270 (28%)
Query: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169
+ E+++ ++V+E D + +C Q C +T CSC GY LL C D+
Sbjct: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
Query: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE------- 214
+EC G C+ + C N GS+ C +C G+ L ED SC+D++EC +
Sbjct: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
Query: 215 ---------------------------------NPCV---------QTCVNTYGSFICR- 231
N C+ TC+NT GS+ C+
Sbjct: 277 FICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK 336
Query: 232 ----CDPGYELEEDGVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDDNRS 285
C GY L E+G C D+DEC+ C H CVN PG++ C C GY +R
Sbjct: 337 NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396
Query: 286 CQDINECE-HRNHTCNLQQTCYNLQGGFKC 314
C D+NEC+ + C C N G + C
Sbjct: 397 CVDVNECQRYPGRLCG--HKCENTLGSYLC 424
Score = 94.4 bits (233), Expect = 2e-19
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266
+ C PC Q C +T +C C GY+L DGV C D++EC C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322
G++ C SC GY L +DN SC+DI+ECE H C C N G F+C ++C+
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 PYLRISDNRCM 333
+++ + C+
Sbjct: 297 GFIQDALGNCI 307
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 193 bits (490), Expect = 3e-49
Identities = 115/322 (35%), Positives = 157/322 (48%), Gaps = 18/322 (5%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ C GF + C+D+DEC P+ C G+ CVN G + C +
Sbjct: 932 CENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVC-GEGHCVNTVGAFRC-EYCDSG 988
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
YR P+ P N P + + C G++ + QC+DVDEC +
Sbjct: 989 YRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR-GWNGQCLDVDECLEPN 1047
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDIDECRYG--YCQQLCANVPGSYSCT 191
N C N EG Y CSC GY C DIDEC+ G C N GS+ CT
Sbjct: 1048 VCANGD--CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCT 1105
Query: 192 CNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C G+ L+ C+D++EC + C C NT GSF C CD GY G HC D++E
Sbjct: 1106 CGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINE 1165
Query: 251 CSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQ 309
C + +CQ +C+N G+Y C+CP G+ LDDN++CQDINECEH C Q C N +
Sbjct: 1166 CLEDKSVCQRGDCINTAGSYDCTCPDGF-QLDDNKTCQDINECEHPG-LCGPQGECLNTE 1223
Query: 310 GGFKCIDPIRCEEPYLRISDNR 331
G F C+ C++ + +D R
Sbjct: 1224 GSFHCV----CQQGFSISADGR 1241
Score = 167 bits (424), Expect = 1e-41
Identities = 111/310 (35%), Positives = 145/310 (46%), Gaps = 20/310 (6%)
Query: 16 CLPSPGNAQA-QCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
C+ SPG+ Q CT GF +GQCLD+DEC GD C N G Y+C +
Sbjct: 1014 CVNSPGSYQCVPCTEGFR--GWNGQCLDVDECLEPNVCANGD--CSNLEGSYMC--SCHK 1067
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDES-NQCVDVDECAT 133
Y + + S C GYQ+ + +QC D+DEC
Sbjct: 1068 GYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ- 1126
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRY--GYCQQL-CANVPGSY 188
H C Q C NTEG + C C GY L C DI+EC CQ+ C N GSY
Sbjct: 1127 HRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSY 1185
Query: 189 SCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEEDGVHCS 246
CTC GF L +D ++CQD+NEC C C+NT GSF C C G+ + DG C
Sbjct: 1186 DCTCPDGFQL-DDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCE 1244
Query: 247 DMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
D+DEC + H C N G++ C C G+ D + C D+NECE + C + C
Sbjct: 1245 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFC 1303
Query: 306 YNLQGGFKCI 315
N++G F C+
Sbjct: 1304 ENVEGSFLCV 1313
Score = 140 bits (352), Expect = 3e-33
Identities = 87/292 (29%), Positives = 125/292 (42%), Gaps = 61/292 (20%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + C G+ L QC DIDEC+ G C N G + C+
Sbjct: 1095 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQ--CRNTEGSFQCV------ 1146
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDE-SNQCVDVDECATD 134
C GY+ + C D++EC D
Sbjct: 1147 -------------------------------------CDQGYRASGLGDHCEDINECLED 1169
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ-CLDIDECRY-GYC--QQLCANVPGSYSC 190
C CINT G Y C+C DG+ L + + C DI+EC + G C Q C N GS+ C
Sbjct: 1170 KSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 1228
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C GF+++ DGR+C+D++EC C C NT GSF C C G++ +DG C D+
Sbjct: 1229 VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 1288
Query: 249 DECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSCQDI-NECEHRNHT 298
+EC +C + C N G++ C C D+N+ + +C R T
Sbjct: 1289 NECELLSGVCGEAFCENVEGSFLCVC------ADENQEYSPMTGQCRSRTST 1334
Score = 135 bits (339), Expect = 1e-31
Identities = 81/222 (36%), Positives = 111/222 (50%), Gaps = 18/222 (8%)
Query: 118 QMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDEC--- 172
Q+ Q +++EC + C CIN YTC C +GY E Q C+DIDEC
Sbjct: 865 QVIAPTQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQV 923
Query: 173 RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICR 231
++ Q C N GS+ C C GF +E+G +C DV+EC + C + CVNT G+F C
Sbjct: 924 QHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCE 983
Query: 232 -CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC-SCPPGYILLDDNRSCQDI 289
CD GY + + G C D+DEC +CVN PG+Y C C G+ N C D+
Sbjct: 984 YCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGF--RGWNGQCLDV 1040
Query: 290 NECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR 331
+EC N N C NL+G + C C + Y R D++
Sbjct: 1041 DECLEPNVCAN--GDCSNLEGSYMC----SCHKGYTRTPDHK 1076
Score = 80.9 bits (198), Expect = 2e-15
Identities = 92/378 (24%), Positives = 129/378 (34%), Gaps = 89/378 (23%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI------ 69
C+ + G+ C +GF LD + C DI+EC P C C+N G + C+
Sbjct: 1178 CINTAGSYDCTCPDGFQLD-DNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFS 1235
Query: 70 ----PRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ- 124
RT +N + A S +C G+Q + Q
Sbjct: 1236 ISADGRTCEDIDECVNNTVCDSHGFCDNTAG-----------SFRCLCYQGFQAPQDGQG 1284
Query: 125 CVDVDECATDSHQCNPTQICINTEGGYTCSCTDG---YWLLEGQC-------LDID---- 170
CVDV+EC S C C N EG + C C D Y + GQC LD+D
Sbjct: 1285 CVDVNECELLSGVCGEA-FCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQP 1343
Query: 171 -----ECRYGYCQ-QLCANVPG----SYSCTCNPGFTLNED------------------- 201
EC Y LC NV C C G ++
Sbjct: 1344 KEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCP 1403
Query: 202 ----------------GRSCQDVNECAT--ENPCVQT-CVNTYGSFICRCDPGYELEEDG 242
G + +D +EC + C C+NT + C C G +
Sbjct: 1404 KGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVK 1463
Query: 243 VHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYIL-LDDNRSCQDINECEHRNHTCNL 301
+ C DMDEC +CVN G+Y C C +L + R + E T
Sbjct: 1464 LQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVY 1523
Query: 302 QQTCY-NLQGGFKCIDPI 318
Q C+ +L + C P+
Sbjct: 1524 QDLCWEHLSDEYVCSRPL 1541
Score = 67.0 bits (162), Expect = 3e-11
Identities = 71/290 (24%), Positives = 109/290 (37%), Gaps = 36/290 (12%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL + + C G D QC D+DEC+ P +C D CVN G Y C T+P+
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCI-DGQCVNTEGSYNCFC-THPM 1498
Query: 76 YRG--------PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVD 127
P + + Y + Y SRPL+ G Q + C
Sbjct: 1499 VLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEY-VCSRPLV---GKQTTYTECCCL 1554
Query: 128 VDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGS 187
E QC + + + C+ + + R Y + +
Sbjct: 1555 YGEAW--GMQCALCPLKDSDDYAQLCN------------IPVTGRRQPYGRDALVDFSEQ 1600
Query: 188 YSCTCNPGFTLNEDGRSCQDVN--ECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244
Y+ +P F + S +++ EC N C CV + C C GY L+ +
Sbjct: 1601 YTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMT 1660
Query: 245 CSDMDECSFSE---FLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDIN 290
C D++EC LC++ +C+N G+Y C C PGY+ D C +N
Sbjct: 1661 CVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 44.7 bits (104), Expect = 2e-04
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 2/69 (2%)
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQTCY 306
+EC CV Y C C GY L +C D+NEC+ N+ +L C
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1683
Query: 307 NLQGGFKCI 315
N G +KC+
Sbjct: 1684 NTDGSYKCL 1692
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 8/96 (8%)
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVN--TYGSF--ICRCDPGYELEED 241
GS PG + ED C V N C Q C +Y + + C PGY+ +
Sbjct: 565 GSQCGKALPGLSKQED--CCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVN 620
Query: 242 GVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGY 277
C D++EC EC+N G+Y C+C G+
Sbjct: 621 NTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 39.3 bits (90), Expect = 0.007
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 102 PNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 159
P+Y ++ + C GY+ + C D++EC P C+NT G Y C+C G+
Sbjct: 601 PSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG--VCPNGECLNTMGSYRCTCKIGF 656
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 224 TYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY----FCSCPPGYIL 279
T GS + PG +ED C S+ CQ +C +P + C PGY
Sbjct: 563 TIGSQCGKALPGLSKQED---CCGTVGTSWGFNKCQ-KCPKKPSYHGYNQMMECLPGYKR 618
Query: 280 LDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
++ N CQDINEC+ + N + C N G ++C
Sbjct: 619 VN-NTFCQDINECQLQGVCPNGE--CLNTMGSYRC 650
Score = 37.4 bits (85), Expect = 0.028
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 6/65 (9%)
Query: 27 CTNGFDLDRQSGQCLDIDECRTI---PEACRGDMMCVNQNGGY--LCIPRTNPVYRGPYS 81
C +G+ LD C+D++EC + C+ + C+N +G Y LC+P P + Y
Sbjct: 1648 CFDGYHLDTAKMTCVDVNECDELNNRMSLCK-NAKCINTDGSYKCLCLPGYVPSDKPNYC 1706
Query: 82 NPYST 86
P +T
Sbjct: 1707 TPLNT 1711
Score = 37.0 bits (84), Expect = 0.036
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 155 CTDGYWLLEGQ-CLDIDECRY-GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSC 205
C GY + C DI+EC+ G C C N GSY CTC GF + SC
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 193 bits (490), Expect = 3e-49
Identities = 115/322 (35%), Positives = 157/322 (48%), Gaps = 18/322 (5%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ C GF + C+D+DEC P+ C G+ CVN G + C +
Sbjct: 606 CENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVC-GEGHCVNTVGAFRC-EYCDSG 662
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
YR P+ P N P + + C G++ + QC+DVDEC +
Sbjct: 663 YRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR-GWNGQCLDVDECLEPN 721
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDIDECRYG--YCQQLCANVPGSYSCT 191
N C N EG Y CSC GY C DIDEC+ G C N GS+ CT
Sbjct: 722 VCANGD--CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCT 779
Query: 192 CNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C G+ L+ C+D++EC + C C NT GSF C CD GY G HC D++E
Sbjct: 780 CGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINE 839
Query: 251 CSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQ 309
C + +CQ +C+N G+Y C+CP G+ LDDN++CQDINECEH C Q C N +
Sbjct: 840 CLEDKSVCQRGDCINTAGSYDCTCPDGF-QLDDNKTCQDINECEHPG-LCGPQGECLNTE 897
Query: 310 GGFKCIDPIRCEEPYLRISDNR 331
G F C+ C++ + +D R
Sbjct: 898 GSFHCV----CQQGFSISADGR 915
Score = 167 bits (424), Expect = 1e-41
Identities = 111/310 (35%), Positives = 145/310 (46%), Gaps = 20/310 (6%)
Query: 16 CLPSPGNAQA-QCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
C+ SPG+ Q CT GF +GQCLD+DEC GD C N G Y+C +
Sbjct: 688 CVNSPGSYQCVPCTEGFR--GWNGQCLDVDECLEPNVCANGD--CSNLEGSYMC--SCHK 741
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDES-NQCVDVDECAT 133
Y + + S C GYQ+ + +QC D+DEC
Sbjct: 742 GYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ- 800
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRY--GYCQQL-CANVPGSY 188
H C Q C NTEG + C C GY L C DI+EC CQ+ C N GSY
Sbjct: 801 HRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSY 859
Query: 189 SCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEEDGVHCS 246
CTC GF L +D ++CQD+NEC C C+NT GSF C C G+ + DG C
Sbjct: 860 DCTCPDGFQL-DDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCE 918
Query: 247 DMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
D+DEC + H C N G++ C C G+ D + C D+NECE + C + C
Sbjct: 919 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFC 977
Query: 306 YNLQGGFKCI 315
N++G F C+
Sbjct: 978 ENVEGSFLCV 987
Score = 140 bits (352), Expect = 3e-33
Identities = 87/292 (29%), Positives = 125/292 (42%), Gaps = 61/292 (20%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + C G+ L QC DIDEC+ G C N G + C+
Sbjct: 769 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQ--CRNTEGSFQCV------ 820
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDE-SNQCVDVDECATD 134
C GY+ + C D++EC D
Sbjct: 821 -------------------------------------CDQGYRASGLGDHCEDINECLED 843
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ-CLDIDECRY-GYC--QQLCANVPGSYSC 190
C CINT G Y C+C DG+ L + + C DI+EC + G C Q C N GS+ C
Sbjct: 844 KSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 902
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C GF+++ DGR+C+D++EC C C NT GSF C C G++ +DG C D+
Sbjct: 903 VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 962
Query: 249 DECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSCQDI-NECEHRNHT 298
+EC +C + C N G++ C C D+N+ + +C R T
Sbjct: 963 NECELLSGVCGEAFCENVEGSFLCVC------ADENQEYSPMTGQCRSRTST 1008
Score = 135 bits (339), Expect = 1e-31
Identities = 81/222 (36%), Positives = 111/222 (50%), Gaps = 18/222 (8%)
Query: 118 QMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDEC--- 172
Q+ Q +++EC + C CIN YTC C +GY E Q C+DIDEC
Sbjct: 539 QVIAPTQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQV 597
Query: 173 RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICR 231
++ Q C N GS+ C C GF +E+G +C DV+EC + C + CVNT G+F C
Sbjct: 598 QHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCE 657
Query: 232 -CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC-SCPPGYILLDDNRSCQDI 289
CD GY + + G C D+DEC +CVN PG+Y C C G+ N C D+
Sbjct: 658 YCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGF--RGWNGQCLDV 714
Query: 290 NECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR 331
+EC N N C NL+G + C C + Y R D++
Sbjct: 715 DECLEPNVCAN--GDCSNLEGSYMC----SCHKGYTRTPDHK 750
Score = 80.9 bits (198), Expect = 2e-15
Identities = 92/378 (24%), Positives = 129/378 (34%), Gaps = 89/378 (23%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI------ 69
C+ + G+ C +GF LD + C DI+EC P C C+N G + C+
Sbjct: 852 CINTAGSYDCTCPDGFQLD-DNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFS 909
Query: 70 ----PRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ- 124
RT +N + A S +C G+Q + Q
Sbjct: 910 ISADGRTCEDIDECVNNTVCDSHGFCDNTAG-----------SFRCLCYQGFQAPQDGQG 958
Query: 125 CVDVDECATDSHQCNPTQICINTEGGYTCSCTDG---YWLLEGQC-------LDID---- 170
CVDV+EC S C C N EG + C C D Y + GQC LD+D
Sbjct: 959 CVDVNECELLSGVCGEA-FCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQP 1017
Query: 171 -----ECRYGYCQ-QLCANVPG----SYSCTCNPGFTLNED------------------- 201
EC Y LC NV C C G ++
Sbjct: 1018 KEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCP 1077
Query: 202 ----------------GRSCQDVNECAT--ENPCVQT-CVNTYGSFICRCDPGYELEEDG 242
G + +D +EC + C C+NT + C C G +
Sbjct: 1078 KGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVK 1137
Query: 243 VHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYIL-LDDNRSCQDINECEHRNHTCNL 301
+ C DMDEC +CVN G+Y C C +L + R + E T
Sbjct: 1138 LQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVY 1197
Query: 302 QQTCY-NLQGGFKCIDPI 318
Q C+ +L + C P+
Sbjct: 1198 QDLCWEHLSDEYVCSRPL 1215
Score = 67.0 bits (162), Expect = 3e-11
Identities = 71/290 (24%), Positives = 109/290 (37%), Gaps = 36/290 (12%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL + + C G D QC D+DEC+ P +C D CVN G Y C T+P+
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCI-DGQCVNTEGSYNCFC-THPM 1172
Query: 76 YRG--------PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVD 127
P + + Y + Y SRPL+ G Q + C
Sbjct: 1173 VLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEY-VCSRPLV---GKQTTYTECCCL 1228
Query: 128 VDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGS 187
E QC + + + C+ + + R Y + +
Sbjct: 1229 YGEAW--GMQCALCPLKDSDDYAQLCN------------IPVTGRRQPYGRDALVDFSEQ 1274
Query: 188 YSCTCNPGFTLNEDGRSCQDVN--ECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244
Y+ +P F + S +++ EC N C CV + C C GY L+ +
Sbjct: 1275 YTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMT 1334
Query: 245 CSDMDECSFSE---FLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDIN 290
C D++EC LC++ +C+N G+Y C C PGY+ D C +N
Sbjct: 1335 CVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 44.7 bits (104), Expect = 2e-04
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 2/69 (2%)
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQTCY 306
+EC CV Y C C GY L +C D+NEC+ N+ +L C
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1357
Query: 307 NLQGGFKCI 315
N G +KC+
Sbjct: 1358 NTDGSYKCL 1366
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 8/96 (8%)
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVN--TYGSF--ICRCDPGYELEED 241
GS PG + ED C V N C Q C +Y + + C PGY+ +
Sbjct: 239 GSQCGKALPGLSKQED--CCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVN 294
Query: 242 GVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGY 277
C D++EC EC+N G+Y C+C G+
Sbjct: 295 NTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 39.3 bits (90), Expect = 0.007
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 102 PNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 159
P+Y ++ + C GY+ + C D++EC P C+NT G Y C+C G+
Sbjct: 275 PSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG--VCPNGECLNTMGSYRCTCKIGF 330
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 224 TYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY----FCSCPPGYIL 279
T GS + PG +ED C S+ CQ +C +P + C PGY
Sbjct: 237 TIGSQCGKALPGLSKQED---CCGTVGTSWGFNKCQ-KCPKKPSYHGYNQMMECLPGYKR 292
Query: 280 LDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
++ N CQDINEC+ + N + C N G ++C
Sbjct: 293 VN-NTFCQDINECQLQGVCPNGE--CLNTMGSYRC 324
Score = 37.4 bits (85), Expect = 0.028
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 6/65 (9%)
Query: 27 CTNGFDLDRQSGQCLDIDECRTI---PEACRGDMMCVNQNGGY--LCIPRTNPVYRGPYS 81
C +G+ LD C+D++EC + C+ + C+N +G Y LC+P P + Y
Sbjct: 1322 CFDGYHLDTAKMTCVDVNECDELNNRMSLCK-NAKCINTDGSYKCLCLPGYVPSDKPNYC 1380
Query: 82 NPYST 86
P +T
Sbjct: 1381 TPLNT 1385
Score = 37.0 bits (84), Expect = 0.036
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 155 CTDGYWLLEGQ-CLDIDECRY-GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSC 205
C GY + C DI+EC+ G C C N GSY CTC GF + SC
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 184 bits (466), Expect = 2e-46
Identities = 106/314 (33%), Positives = 149/314 (47%), Gaps = 24/314 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + +C +GF LD + C DIDECR P+ C G +CVN G + C
Sbjct: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLC-GSGICVNTPGSFEC-----EC 1142
Query: 76 YRGPYS------NPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDV 128
+ G S N P + N S C G+++ S + CVD+
Sbjct: 1143 FEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEG-SFQCDCPLGHELSPSREDCVDI 1201
Query: 129 DECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANV 184
+EC+ + C + C+N G Y CSC GY + C DIDEC G C C N
Sbjct: 1202 NECSLSDNLCRNGK-CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNS 1260
Query: 185 PGSYSCTCNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICRCDPGYELEED 241
GSY C+C+ G+ L DGRSC D++EC NP + C N G + C C G+ D
Sbjct: 1261 EGSYECSCSEGYALMPDGRSCADIDECEN-NPDICDGGQCTNIPGEYRCLCYDGFMASMD 1319
Query: 242 GVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCN 300
C D++EC + +C EC N G++ C C GY + C D++ECE H C+
Sbjct: 1320 MKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCD 1379
Query: 301 LQQTCYNLQGGFKC 314
+ +C N+ G FKC
Sbjct: 1380 MHASCLNIPGSFKC 1393
Score = 176 bits (445), Expect = 5e-44
Identities = 97/323 (30%), Positives = 139/323 (43%), Gaps = 58/323 (17%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ + C G+ D C+D+DEC P+ C + +C N G Y C
Sbjct: 2465 CINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQCS------ 2516
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATD 134
C GY + E + C D+DEC T
Sbjct: 2517 -------------------------------------CPRGYVLQEDGKTCKDLDECQTK 2539
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--RYGYC--QQLCANVPGSYSC 190
H C +C+NT GG+TC C G+ C+D +EC + C + +C N PGS+SC
Sbjct: 2540 QHNCQ--FLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC 2597
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C GF+L+ G +C+DV+EC + C C N G + C C GY C D +E
Sbjct: 2598 ECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENE 2657
Query: 251 CSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQG 310
CS C N G+Y C+CP G+ + +C D+NEC + CN C N +G
Sbjct: 2658 CSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCN--YGCSNTEG 2715
Query: 311 GFKCIDPIRCEEPYLRISDNRCM 333
G+ C C Y R+ C+
Sbjct: 2716 GYLC----GCPPGYYRVGQGHCV 2734
Score = 173 bits (439), Expect = 2e-43
Identities = 111/361 (30%), Positives = 160/361 (44%), Gaps = 71/361 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ C G+ + + + C D+DEC C C+N G + C
Sbjct: 1341 CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC------- 1393
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
CR G+ + +C+D+DEC+ +
Sbjct: 1394 ------------------------------------SCREGW-IGNGIKCIDLDECSNGT 1416
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--RYGYCQQ-LCANVPGSYSCTC 192
HQC+ C+NT G Y C+C++G+ C D+DEC C+ C NVPG+Y C C
Sbjct: 1417 HQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCEC 1476
Query: 193 NPGFTLNEDGRSCQDVNECATENPCV-QTCVNTYGSFICRCDPGYELEEDGVHCSDMDEC 251
GFT D RSCQD++EC+ +N CV TC N G F C CD GYEL+ G +C+D+DEC
Sbjct: 1477 EMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC 1536
Query: 252 SFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD--INECEHR-------NHTCNLQ 302
+ CVN PG Y C+CPP + L C D + C + + +CN +
Sbjct: 1537 ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTE 1596
Query: 303 --------QTCYNLQGGFKCIDPIRCEE-PYLRISDNRCMCPAENPGCRDQPFTILYRDM 353
C +L G +P CE P + ++ +CP G R P TI+ D+
Sbjct: 1597 IGVGVSRSSCCCSL--GKAWGNP--CETCPPVNSTEYYTLCPG-GEGFRPNPITIILEDI 1651
Query: 354 D 354
D
Sbjct: 1652 D 1652
Score = 172 bits (436), Expect = 6e-43
Identities = 110/344 (31%), Positives = 155/344 (45%), Gaps = 49/344 (14%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDI-----------DEC-RTIPEACRGDMMCVNQN 63
C+ S G+ +C G LD CLDI DEC +P R D C
Sbjct: 971 CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVG 1030
Query: 64 GGYLCIPRTNPVYRGPYSNPYST--PYSGPYPAAAPPLSA-PNYPTISR----PLICRFG 116
+ P P + Y T P + L+ P Y I+ P +C +G
Sbjct: 1031 AAWGTECEECPK---PGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087
Query: 117 ----------------YQMD-ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 159
+ +D E C D+DEC C + IC+NT G + C C +GY
Sbjct: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFECECFEGY 1146
Query: 160 ---WLLEGQCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECA- 212
+++ C+DIDEC C+ C N GS+ C C G L+ C D+NEC+
Sbjct: 1147 ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSL 1206
Query: 213 TENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC 271
++N C CVN G++ C C+PGY+ D C+D+DEC C +C N G+Y C
Sbjct: 1207 SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC 1266
Query: 272 SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
SC GY L+ D RSC DI+ECE+ C+ Q C N+ G ++C+
Sbjct: 1267 SCSEGYALMPDGRSCADIDECENNPDICDGGQ-CTNIPGEYRCL 1309
Score = 172 bits (436), Expect = 6e-43
Identities = 114/344 (33%), Positives = 155/344 (45%), Gaps = 65/344 (18%)
Query: 18 PSPGNAQAQ--CTN--GFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTN 73
P+PG A + C N GF D +G+ +DIDEC+ IP C + C+NQ G + C T
Sbjct: 1780 PTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSFRCECPTG 1838
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECAT 133
F Y D C D+DEC+
Sbjct: 1839 -----------------------------------------FSYN-DLLLVCEDIDECSN 1856
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLL-EGQCLDIDECRY--GYCQQ-LCANVPGSYS 189
+ C CIN+ G Y C C G+ L G C+D +EC C LC ++ GSY
Sbjct: 1857 GDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQ 1916
Query: 190 CTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C C+ GF ++D C DV+EC +PC TC NT GS+ C C PG+EL + C D+
Sbjct: 1917 CICHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDI 1974
Query: 249 DECS--FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
DECS F + C N+ G++ C C GY L D ++C D NEC +C+ TC
Sbjct: 1975 DECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCS-PGTCQ 2033
Query: 307 NLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILY 350
NL+G F+CI P P + C+ E C + P L+
Sbjct: 2034 NLEGSFRCICP-----PGYEVKSENCIDINE---CDEDPNICLF 2069
Score = 169 bits (427), Expect = 6e-42
Identities = 104/310 (33%), Positives = 138/310 (44%), Gaps = 15/310 (4%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C S G+ + C+ G+ L C DIDEC P+ C G C N G Y C+ +
Sbjct: 1257 CTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQ-CTNIPGEYRCLCYDGFM 1315
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATD 134
N S C+ GY + + C DVDEC
Sbjct: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKG-SFICHCQLGYSVKKGTTGCTDVDECEIG 1374
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG-QCLDIDECRYGYCQ----QLCANVPGSYS 189
+H C+ C+N G + CSC +G W+ G +C+D+DEC G Q C N PGSY
Sbjct: 1375 AHNCDMHASCLNIPGSFKCSCREG-WIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
Query: 190 CTCNPGFTLNEDGRSCQDVNECATE-NPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSD 247
C C+ GFT DG +C DV+ECA N C C+N G++ C C+ G+ D C D
Sbjct: 1434 CACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQD 1491
Query: 248 MDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
+DECSF C N PG + C C GY L +C DI+EC + N C N
Sbjct: 1492 IDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVN--GLCVN 1549
Query: 308 LQGGFKCIDP 317
G ++C P
Sbjct: 1550 TPGRYECNCP 1559
Score = 165 bits (418), Expect = 7e-41
Identities = 104/337 (30%), Positives = 149/337 (44%), Gaps = 60/337 (17%)
Query: 5 KRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNG 64
K I + +C+ G+ + +C GF + C DIDEC C+ + C+N G
Sbjct: 1813 KEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
Query: 65 GYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ 124
Y C C G+++ +
Sbjct: 1873 SYRC-------------------------------------------ECAAGFKLSPNGA 1889
Query: 125 CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGYC-QQLC 181
CVD +EC + C+ +C++ +G Y C C +G+ + Q C+D+DEC C C
Sbjct: 1890 CVDRNECLEIPNVCS-HGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTC 1948
Query: 182 ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICRCDPGYEL 238
N GSY+C C PGF L + C D++EC++ V C N GSF C C+ GYEL
Sbjct: 1949 KNTVGSYNCLCYPGFELTHN-NDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYEL 2007
Query: 239 EEDGVHCSDMDECSFSEFLCQ-HECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNH 297
DG +C D +EC C C N G++ C CPPGY + +N C DINEC+ +
Sbjct: 2008 TPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPN 2065
Query: 298 TCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMC 334
C L +C N GGF+C+ P P +SDN C
Sbjct: 2066 IC-LFGSCTNTPGGFQCLCP-----PGFVLSDNGRRC 2096
Score = 158 bits (400), Expect = 8e-39
Identities = 88/244 (36%), Positives = 118/244 (48%), Gaps = 34/244 (13%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDID 170
C GY+ D + C+DVDEC S+ C C+NT G Y C C G+ + C+DID
Sbjct: 521 CNMGYKQDANGDCIDVDECT--SNPCTNGD-CVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 171 ECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYG 226
EC C+ C N GS+ C CN GF L DG++C D +EC T N C+ C+N G
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
Query: 227 SFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSC 286
SF C C PG+ L +G +C+D+DEC C+N G++ C CPPG + D R C
Sbjct: 638 SFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC 697
Query: 287 QDINECEHRNHTCNLQQTCYNLQGGFK---CIDPIR---------CEEPYLRISDNRCMC 334
D +++ TCY GG K C+ P C P + C
Sbjct: 698 VD----------THMRSTCY---GGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPC 744
Query: 335 PAEN 338
PA+N
Sbjct: 745 PAKN 748
Score = 157 bits (397), Expect = 2e-38
Identities = 108/364 (29%), Positives = 160/364 (43%), Gaps = 65/364 (17%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C+ PG A+ G C+D +ECRT P C CVN G Y C N
Sbjct: 2320 MCICPPGMARRPDGEG---------CVDENECRTKPGICENG-RCVNIIGSYRC--ECNE 2367
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICR----------FGYQMD---- 120
++ S A + + SR L+ + +G+Q +
Sbjct: 2368 GFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPL 2427
Query: 121 ---------------ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLE 163
+ D+DEC + C Q CINT G + C C GY +
Sbjct: 2428 PGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQ-CINTMGSFRCFCKVGYTTDISG 2486
Query: 164 GQCLDIDECRYG--YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQT 220
C+D+DEC C +C N GSY C+C G+ L EDG++C+D++EC T ++ C
Sbjct: 2487 TSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFL 2546
Query: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHE--CVNQPGTYFCSCPPGYI 278
CVNT G F C+C PG+ + C D +EC LC + C N PG++ C C G+
Sbjct: 2547 CVNTLGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFS 2604
Query: 279 LLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-------ISDNR 331
L +C+D++EC+ NH C Q C N+ GG++C C + Y++ + +N
Sbjct: 2605 LDATGLNCEDVDECD-GNHRC--QHGCQNILGGYRC----GCPQGYIQHYQWNQCVDENE 2657
Query: 332 CMCP 335
C P
Sbjct: 2658 CSNP 2661
Score = 145 bits (365), Expect = 9e-35
Identities = 106/364 (29%), Positives = 150/364 (41%), Gaps = 94/364 (25%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ Q C GF+L C+D DEC T G MC+N++G + CI + V
Sbjct: 591 CVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNG--MCINEDGSFKCICKPGFV 648
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
APN C DVDEC T
Sbjct: 649 L------------------------APN------------------GRYCTDVDECQTPG 666
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWL-LEGQ-CLDI---DECRYGYCQQLCAN-----VP 185
N CIN+EG + C C G + ++G+ C+D C G + +C V
Sbjct: 667 ICMNGH--CINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVT 724
Query: 186 GSYSCTCNPGFTLNEDGRSC----------------------QDVNECATE-NPCVQ-TC 221
S C NP + E + C +D+NECA + + C C
Sbjct: 725 KSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGIC 784
Query: 222 VNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILL 280
N GS+ C C+ GYE + G +C D+DEC + LC + C N PG+Y C+CPPGY+
Sbjct: 785 ENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFR 844
Query: 281 DDNRSCQDINECEHR---NHTCNLQQTCYNLQ---------GGFKCIDPIRCEEPYLRIS 328
+ +C+DINECE N C +N + G CID ++ +L I
Sbjct: 845 TETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLK-GTCWLNIQ 903
Query: 329 DNRC 332
D+RC
Sbjct: 904 DSRC 907
Score = 142 bits (359), Expect = 5e-34
Identities = 73/199 (36%), Positives = 103/199 (51%), Gaps = 9/199 (4%)
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL-LEGQCLDIDECRYGYCQQL- 180
NQ +D+ C ++ C + CI T Y C C GY G C+D+DEC C
Sbjct: 492 NQTIDI--CKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGD 548
Query: 181 CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYEL 238
C N PGSY C C+ GF ++C D++EC + CVNT GSF C C+ G+EL
Sbjct: 549 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFEL 608
Query: 239 EEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHT 298
DG +C D DEC+ + C+N+ G++ C C PG++L + R C D++EC+
Sbjct: 609 TTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGIC 668
Query: 299 CNLQQTCYNLQGGFKCIDP 317
N C N +G F+C P
Sbjct: 669 MN--GHCINSEGSFRCDCP 685
Score = 142 bits (358), Expect = 6e-34
Identities = 113/393 (28%), Positives = 155/393 (39%), Gaps = 80/393 (20%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC------ 68
+C+ G+ + C GF L C D+DEC+T P C C+N G + C
Sbjct: 631 MCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT-PGICMNGH-CINSEGSFRCDCPPGL 688
Query: 69 -----------IPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNY----PTISRPL-- 111
+ Y G P+ G + + P+Y P P
Sbjct: 689 AVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKN 748
Query: 112 ------ICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLE 163
+C G + + D++ECA D C IC N G Y C+C GY
Sbjct: 749 SAEFHGLCSSGVGITVDGR--DINECALDPDIC-ANGICENLRGSYRCNCNSGYEPDASG 805
Query: 164 GQCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ- 219
C+DIDEC C LC N PGSYSCTC PG+ + +C+D+NEC + NPCV
Sbjct: 806 RNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECES-NPCVNG 864
Query: 220 TCVNTYGSFICRCDPGYELEEDGVHCSD-------------MDECSFSEFLCQHECVNQP 266
C N GSF C C PG +L G+ C D E + + + EC
Sbjct: 865 ACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATL 924
Query: 267 GTYFCS----------CPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCID 316
G + S CP G + +C+D+NECE C C N +G F C
Sbjct: 925 GAAWGSPCERCELDTACPRGLARI-KGVTCEDVNECEVFPGVCP-NGRCVNSKGSFHCEC 982
Query: 317 P--------------IRCEEPYLRISDNRCMCP 335
P IR E+ YL+ ++ C+ P
Sbjct: 983 PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHP 1015
Score = 140 bits (352), Expect = 3e-33
Identities = 99/340 (29%), Positives = 144/340 (42%), Gaps = 43/340 (12%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C G+ + C G++L C+D +EC +P +C C N G + CI P
Sbjct: 1990 CFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRCI--CPPG 2046
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDE--CA 132
Y N P S N P +C G+ + D +C D + C
Sbjct: 2047 YEVKSENCIDINECDEDPNICLFGSCTNTPG-GFQCLCPPGFVLSDNGRRCFDTRQSFCF 2105
Query: 133 T--DSHQCNPTQICINTEGGYTCS-------------------------CTDGYWL---L 162
T ++ +C+ + T+ CS C G+ L
Sbjct: 2106 TNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSL 2165
Query: 163 EGQCLDIDECRY--GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ 219
D++EC G C C N GS+ C C G+ L+ G C D +EC+ NPC
Sbjct: 2166 HDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGN 2225
Query: 220 -TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYI 278
TC N GSF C C+ G+E ++C D++EC+ + LC C+N G+Y C+CP GY
Sbjct: 2226 GTCTNVIGSFECNCNEGFE-PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284
Query: 279 LLDDNRSCQDINECEHRNHTCNLQ-QTCYNLQGGFKCIDP 317
L +D + C+D++EC H C + C NL G F CI P
Sbjct: 2285 LREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICP 2324
Score = 133 bits (335), Expect = 3e-31
Identities = 107/371 (28%), Positives = 157/371 (42%), Gaps = 62/371 (16%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ SPG+ + +C GF L +G C+D +EC IP C + CV+ G Y CI
Sbjct: 1867 CINSPGSYRCECAAGFKLS-PNGACVDRNECLEIPNVCSHGL-CVDLQGSYQCI-----C 1919
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDESNQCVDVDECAT 133
+ G ++ T P S +C G+++ +N C+D+DEC++
Sbjct: 1920 HNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSS 1979
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDEC--RYGYCQQ-LCANVPGSY 188
Q C N G + C C +GY L C+D +EC G C C N+ GS+
Sbjct: 1980 FFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSF 2039
Query: 189 SCTCNPGFTLNEDGRSCQDVNECATE-NPCV-QTCVNTYGSFICRCDPGYELEEDGVHCS 246
C C PG+ + + +C D+NEC + N C+ +C NT G F C C PG+ L ++G C
Sbjct: 2040 RCICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCF 2097
Query: 247 DM-----------DECS----FSEFLCQHECVNQPG----------------TYFCSCPP 275
D +CS F+ + C PG + CP
Sbjct: 2098 DTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPY 2157
Query: 276 GY---ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC 332
G+ L D R +D+NEC C+ Q C N G F+C P+ Y + RC
Sbjct: 2158 GHGTVPSLHDTR--EDVNECLESPGICSNGQ-CINTDGSFRCECPMGYNLDYTGV---RC 2211
Query: 333 M----CPAENP 339
+ C NP
Sbjct: 2212 VDTDECSIGNP 2222
Score = 133 bits (334), Expect = 4e-31
Identities = 107/368 (29%), Positives = 140/368 (38%), Gaps = 99/368 (26%)
Query: 11 TILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIP 70
+I A C+ +PG+ + C+ GF D C D+DEC C C+N G Y C
Sbjct: 1420 SINAQCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENINLCENG-QCLNVPGAYRC-- 1474
Query: 71 RTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGY-QMDESNQCVDVD 129
C G+ +S C D+D
Sbjct: 1475 -----------------------------------------ECEMGFTPASDSRSCQDID 1493
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECR--YGYCQQLCANVP 185
EC+ + T C N G + C C DGY L G C DIDEC LC N P
Sbjct: 1494 ECSFQNICVFGT--CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTP 1551
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVN----------------ECATE--------------- 214
G Y C C P F LN G C D C TE
Sbjct: 1552 GRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLG 1611
Query: 215 ----NPCVQTC--VNTYGSF-ICRCDPGYELEEDGVHCSDMDECSFSEFLCQ-HECVNQP 266
NPC +TC VN+ + +C G+ + D+DEC LCQ C+N
Sbjct: 1612 KAWGNPC-ETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTF 1670
Query: 267 GTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR 326
G++ C CP GY L +D R C+DI+EC C TCYN G + CI C Y++
Sbjct: 1671 GSFQCECPQGYYLSEDTRICEDIDECFAHPGVCG-PGTCYNTLGNYTCI----CPPEYMQ 1725
Query: 327 IS-DNRCM 333
++ + CM
Sbjct: 1726 VNGGHNCM 1733
Score = 129 bits (323), Expect = 7e-30
Identities = 106/376 (28%), Positives = 146/376 (38%), Gaps = 101/376 (26%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+P+ + + +C G+ D +G C+D+DEC + P GD CVN G Y C
Sbjct: 510 CIPTVSSYRCECNMGYKQDA-NGDCIDVDECTSNP-CTNGD--CVNTPGSYYC------- 558
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATD 134
C G+Q + Q C+D+DEC +
Sbjct: 559 ------------------------------------KCHAGFQRTPTKQACIDIDECIQN 582
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDEC-RYGYC-QQLCANVPGSYSC 190
C + C+NT+G + C C G+ L C+D DEC C +C N GS+ C
Sbjct: 583 GVLCKNGR-CVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC 641
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSD-- 247
C PGF L +GR C DV+EC T C+ C+N+ GSF C C PG + DG C D
Sbjct: 642 ICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTH 701
Query: 248 -----------------------MDEC-------SFSEFLCQHECVNQPGTYFCSCPPGY 277
EC F E CQ + C G
Sbjct: 702 MRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE-PCQPCPAKNSAEFHGLCSSGV 760
Query: 278 ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC-----IDPIRCEEPYLRISD--- 329
+ D R DINEC C C NL+G ++C +P + I +
Sbjct: 761 GITVDGR---DINECALDPDIC-ANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLV 816
Query: 330 NRCMCPAENPGCRDQP 345
NR +C +N CR+ P
Sbjct: 817 NRLLC--DNGLCRNTP 830
Score = 126 bits (316), Expect = 5e-29
Identities = 98/339 (28%), Positives = 136/339 (40%), Gaps = 91/339 (26%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ + +C G++LD +C+D DEC +I C G+ C N G + C
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPC-GNGTCTNVIGSFEC------- 2237
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
C G++ C D++ECA +
Sbjct: 2238 ------------------------------------NCNEGFEPGPMMNCEDINECAQNP 2261
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQ---QLCANVPGSY 188
C C+NT G Y C+C GY L E Q C D+DEC G C+ +C N+ G++
Sbjct: 2262 LLC--AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTF 2319
Query: 189 SCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEEDGVHCS 246
C C PG DG C D NEC T+ + CVN GS+ C C+ G++ G C
Sbjct: 2320 MCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECL 2379
Query: 247 DMDE-CSFSEFL---CQ-----------------------HEC--VNQPGT--YFCSCPP 275
D + F+E L CQ H+C PGT Y CP
Sbjct: 2380 DNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPH 2439
Query: 276 GYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
G D R DI+EC+ + C Q C N G F+C
Sbjct: 2440 GPGYTTDGR---DIDECKVMPNLCTNGQ-CINTMGSFRC 2474
Score = 124 bits (310), Expect = 2e-28
Identities = 104/385 (27%), Positives = 142/385 (36%), Gaps = 88/385 (22%)
Query: 10 VTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC- 68
+ + C PG C +G++LDR G C DIDEC G +CVN G Y C
Sbjct: 1500 ICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNG--LCVNTPGRYECN 1557
Query: 69 IP---RTNPVYRGPYSNPYSTPYSGPYPAA------------------------------ 95
P + NP G N Y P
Sbjct: 1558 CPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNP 1617
Query: 96 ---APPLSAPNYPTISRPLICRFGYQMDESNQCV---DVDECATDSHQCNPTQICINTEG 149
PP+++ Y T+ C G + + D+DEC C CINT G
Sbjct: 1618 CETCPPVNSTEYYTL-----CPGGEGFRPNPITIILEDIDECQELPGLCQGGN-CINTFG 1671
Query: 150 GYTCSCTDGYWLLEGQ--CLDIDEC--RYGYCQQ-LCANVPGSYSCTCNPGFTLNEDGRS 204
+ C C GY+L E C DIDEC G C C N G+Y+C C P + G +
Sbjct: 1672 SFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHN 1731
Query: 205 CQDVNE-----------CATENPCVQT---CVNTYG--------------------SFIC 230
C D+ + C E P T C TY IC
Sbjct: 1732 CMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
Query: 231 RCDPGYELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDI 289
PG+ + D+DEC +C + C+NQ G++ C CP G+ D C+DI
Sbjct: 1792 GNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDI 1851
Query: 290 NECEHRNHTCNLQQTCYNLQGGFKC 314
+EC + ++ C C N G ++C
Sbjct: 1852 DECSNGDNLCQRNADCINSPGSYRC 1876
Score = 120 bits (302), Expect = 2e-27
Identities = 77/227 (33%), Positives = 102/227 (44%), Gaps = 57/227 (25%)
Query: 168 DIDECRY--GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNEC------------- 211
DI+EC+ G C C N GS+ C CN GF L+ + R+C D++EC
Sbjct: 1073 DINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICV 1132
Query: 212 -----------------------------ATENPCV---QTCVNTYGSFICRCDPGYELE 239
NP + TCVNT GSF C C G+EL
Sbjct: 1133 NTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELS 1192
Query: 240 EDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHT 298
C D++ECS S+ LC++ +CVN GTY CSC PGY D + C DI+EC N
Sbjct: 1193 PSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGG 1252
Query: 299 CNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQP 345
C+ Q C N +G ++C C E Y + D R A+ C + P
Sbjct: 1253 CDTQ--CTNSEGSYEC----SCSEGYALMPDGRSC--ADIDECENNP 1291
Score = 115 bits (289), Expect = 6e-26
Identities = 101/370 (27%), Positives = 151/370 (40%), Gaps = 73/370 (19%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIP---EACRGDMMCVN---------Q 62
LC +PG+ C G+ ++ C DI+EC + P ACR ++ N
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLS 884
Query: 63 NGGYLCIPRTNPVY-------RGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRF 115
+ G +CI R + +T S +P C
Sbjct: 885 STGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSP-CERCELDTACPR 943
Query: 116 GYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ---CLDI--D 170
G + C DV+EC C P C+N++G + C C +G L+G CLDI +
Sbjct: 944 GLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGL-TLDGTGRVCLDIRME 1001
Query: 171 ECRYGYCQQLCAN-VPGSY---SCTCNPGFTLNEDGRSC--------------------- 205
+C + + C + VPG + +C C G + C
Sbjct: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
Query: 206 ----------QDVNEC-ATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSF 253
+D+NEC A C C NT GSF CRC+ G+ L+ + +C+D+DEC
Sbjct: 1062 GDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRI 1121
Query: 254 SEFLC-QHECVNQPGTYFCSCPPGY----ILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
S LC CVN PG++ C C GY +++ ++C DI+ECE C TC N
Sbjct: 1122 SPDLCGSGICVNTPGSFECECFEGYESGFMMM---KNCMDIDECERNPLLCR-GGTCVNT 1177
Query: 309 QGGFKCIDPI 318
+G F+C P+
Sbjct: 1178 EGSFQCDCPL 1187
Score = 108 bits (271), Expect = 8e-24
Identities = 89/335 (26%), Positives = 126/335 (37%), Gaps = 91/335 (27%)
Query: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
C P P A+ C++G + DI+EC P+ C + C N G Y C
Sbjct: 741 CQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICANGI-CENLRGSYRCN-- 794
Query: 72 TNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDE 130
C GY+ D S + C+D+DE
Sbjct: 795 -----------------------------------------CNSGYEPDASGRNCIDIDE 813
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGY-WLLEGQ-CLDIDECRYGYC-QQLCANVPGS 187
C + C+ +C NT G Y+C+C GY + E + C DI+EC C C N GS
Sbjct: 814 CLVNRLLCD-NGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGS 872
Query: 188 YSCTCNPGFTLNEDGRSCQD------------------VNECATENPCVQTCVNTYGSFI 229
++C C+PG L+ G C D +N ++ C T +GS
Sbjct: 873 FNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC 932
Query: 230 CRCD-----PGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDN 283
RC+ P GV C D++EC +C + CVN G++ C CP G L
Sbjct: 933 ERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTG 992
Query: 284 RSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPI 318
R C DI + CY +CI P+
Sbjct: 993 RVCLDIR-----------MEQCYLKWDEDECIHPV 1016
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/179 (31%), Positives = 77/179 (43%), Gaps = 19/179 (10%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC 172
C +G+ + + C T + Q+C G C+ T C
Sbjct: 198 CVYGFTGPQCERDYRTGPCFTQVNN----QMCQGQLTGIVCTKT--------LCCATIGR 245
Query: 173 RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ--TCVNTYGSFIC 230
+G+ ++C P C GF N +CQDV+EC Q C+NT GSF C
Sbjct: 246 AWGHPCEMCPAQPQP----CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFEC 301
Query: 231 RCDPGYELEEDGVHCSDMDECSFSEFLCQ-HECVNQPGTYFCSCPPGYILLDDNRSCQD 288
RC G++ E C D+DECS +C+ EC N G+YFC CP GY+ D C D
Sbjct: 302 RCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360
Score = 60.5 bits (145), Expect = 3e-09
Identities = 59/227 (25%), Positives = 90/227 (39%), Gaps = 32/227 (14%)
Query: 122 SNQCVDVDECATDSHQCNPTQICINTEGGYTCS--CTDGYWLLEGQCLDIDECR--YGYC 177
S +C++ CA D QC I G C C +G G+C+ + C YG+
Sbjct: 150 SVRCMNGGTCADDHCQCQKGYIGTYC-GQPVCENGCQNG-----GRCIGPNRCACVYGFT 203
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQD--VNECATENPCVQTCVNTYGS--FICRCD 233
C P FT + + CQ T+ C T +G +C
Sbjct: 204 GPQCER-----DYRTGPCFT-QVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Query: 234 P-----GYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQ 287
P G+ C D+DEC +CQ C+N G++ C CP G+ + + C+
Sbjct: 258 PQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCE 317
Query: 288 DINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISD-NRCM 333
DI+EC C + C N G + C+ C Y+ +D +RC+
Sbjct: 318 DIDECSIIPGICETGE-CSNTVGSYFCV----CPRGYVTSTDGSRCI 359
Score = 59.7 bits (143), Expect = 5e-09
Identities = 52/183 (28%), Positives = 68/183 (37%), Gaps = 55/183 (30%)
Query: 23 AQAQ-CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYS 81
AQ Q C GF + ++G C D+DEC+ IP C+G C+N G + C
Sbjct: 256 AQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGG-NCINTVGSFEC------------- 301
Query: 82 NPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATDSHQCNP 140
C G++ E+ Q C D+DEC+ C
Sbjct: 302 ------------------------------RCPAGHKQSETTQKCEDIDECSIIPGICE- 330
Query: 141 TQICINTEGGYTCSCTDGYWLLE--GQCLD--IDECRYGYCQQLCA-NVPG---SYSCTC 192
T C NT G Y C C GY +C+D C G CA +PG C C
Sbjct: 331 TGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCC 390
Query: 193 NPG 195
PG
Sbjct: 391 EPG 393
Score = 43.9 bits (102), Expect = 3e-04
Identities = 20/55 (36%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
A C + G+ + C +GF D+ S C D++EC + C + C N GGYLC
Sbjct: 2667 ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLC 2719
Score = 39.7 bits (91), Expect = 0.006
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI 69
C+ + G+ + +C G + +C DIDEC IP C C N G Y C+
Sbjct: 292 CINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG-ECSNTVGSYFCV 344
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 183 bits (465), Expect = 2e-46
Identities = 108/311 (34%), Positives = 145/311 (46%), Gaps = 18/311 (5%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + +C +GF LD + C DIDECR P+ C G CVN G + C + +
Sbjct: 1044 CRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPGDFEC--KCDEG 1100
Query: 76 YRGPY---SNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDES-NQCVDVDEC 131
Y + N P N R C G+Q+ + + C+D++EC
Sbjct: 1101 YESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYR-CECPPGHQLSPNISACIDINEC 1159
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPGS 187
+H C P C+N G Y C+C GY + C+DIDEC G C+ C N GS
Sbjct: 1160 ELSAHLC-PNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGS 1218
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICRCDPGYELEEDGVH 244
Y C+C PGF L D RSC D++EC +NP + C N G + C C G+ ED
Sbjct: 1219 YECSCQPGFALMPDQRSCTDIDECE-DNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKT 1277
Query: 245 CSDMDECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQ 303
C D++EC + +C C N G++ C C GY C DINECE H C
Sbjct: 1278 CVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHA 1337
Query: 304 TCYNLQGGFKC 314
C N G FKC
Sbjct: 1338 VCTNTAGSFKC 1348
Score = 177 bits (450), Expect = 1e-44
Identities = 102/297 (34%), Positives = 136/297 (45%), Gaps = 16/297 (5%)
Query: 42 DIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSA 101
DIDEC+ I + CR CVN G Y CI +T Y + + A P
Sbjct: 2402 DIDECKVIHDVCRNGE-CVNDRGSYHCICKTG--YTPDITGTSCVDLNECNQAPKPCNFI 2458
Query: 102 PNYPTISRPLICRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW 160
S C GY + E + C D+DECAT H C +C+NT GG+TC C G+
Sbjct: 2459 CKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTCKCPPGFT 2516
Query: 161 LLEGQCLDIDECR--YGYC--QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP 216
C+D +EC C + +C N PGS++C C GF+L++ G SC+DV+EC +
Sbjct: 2517 QHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHR 2576
Query: 217 CVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPG 276
C C N G + C C GY C D +EC + C N G+Y C CP G
Sbjct: 2577 CQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAG 2636
Query: 277 YILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCM 333
+ + CQDINEC C+ C N +GG+ C C Y RI C+
Sbjct: 2637 FQYEQFSGGCQDINECGSAQAPCS--YGCSNTEGGYLC----GCPPGYFRIGQGHCV 2687
Score = 177 bits (448), Expect = 2e-44
Identities = 108/319 (33%), Positives = 144/319 (45%), Gaps = 60/319 (18%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C + G+ + +C G L C+DI+EC C CVN G Y C NP
Sbjct: 1128 VCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNG-RCVNLIGKYQC--ACNP 1184
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
Y +STP + CVD+DEC+
Sbjct: 1185 GY-------HSTP---------------------------------DRLFCVDIDECSIM 1204
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDEC--RYGYCQ-QLCANVPGSYS 189
+ C C N+EG Y CSC G+ L+ Q C DIDEC C C N+PG Y
Sbjct: 1205 NGGCE--TFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYR 1262
Query: 190 CTCNPGFTLNEDGRSCQDVNEC-ATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSD 247
C C GF +ED ++C DVNEC N C+ TC NT GSFIC CD GY ++ C+D
Sbjct: 1263 CLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTD 1322
Query: 248 MDECSFSEFLCQHE--CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
++EC C C N G++ CSC PG+I D C D++EC + H C+ C
Sbjct: 1323 INECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADC 1380
Query: 306 YNLQGGFKCIDPIRCEEPY 324
N G ++C+ C+E Y
Sbjct: 1381 KNTMGSYRCL----CKEGY 1395
Score = 176 bits (447), Expect = 3e-44
Identities = 117/344 (34%), Positives = 161/344 (46%), Gaps = 47/344 (13%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDI----------DECRTIPEACRG--DMMCVNQ 62
LC+ + G+ + QC +G LD CLDI DE T+P A R D C +
Sbjct: 925 LCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSV 984
Query: 63 NGGY------LCIPRTNPVY-----RGPYSNPYSTPYSGPY----------PAAAPPLSA 101
+ C R P Y RGP P+ P+
Sbjct: 985 GAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKC 1044
Query: 102 PNYPTI-SRPLICRFGYQMD-ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 159
N TI S C G+ +D E C D+DEC C Q C+NT G + C C +GY
Sbjct: 1045 RN--TIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ-CVNTPGDFECKCDEGY 1101
Query: 160 ---WLLEGQCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECA- 212
+++ C+DIDEC+ C+ +C N GSY C C PG L+ + +C D+NEC
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECEL 1161
Query: 213 TENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC 271
+ + C CVN G + C C+PGY D + C D+DECS C+ C N G+Y C
Sbjct: 1162 SAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYEC 1221
Query: 272 SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
SC PG+ L+ D RSC DI+ECE + C+ Q C N+ G ++C+
Sbjct: 1222 SCQPGFALMPDQRSCTDIDECEDNPNICDGGQ-CTNIPGEYRCL 1264
Score = 176 bits (445), Expect = 5e-44
Identities = 117/314 (37%), Positives = 154/314 (49%), Gaps = 25/314 (7%)
Query: 30 GFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYS 89
GF +D +G +DIDECR IP C + C+N G + C PV G + N
Sbjct: 1754 GFVIDIYTGLPVDIDECREIPGVCENGV-CINMVGSFRC---ECPV--GFFYNDKLLVCE 1807
Query: 90 GPYPAAAPPLSAPNYPTI----SRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICI 145
P+ N I S C+ GY+ + QC D +EC + C+ Q CI
Sbjct: 1808 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQ-CI 1866
Query: 146 NTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGYC-QQLCANVPGSYSCTCNPGFTLNEDG 202
+T G + C C G+ + Q CLDI+EC C C N GS++C CN GF L+ +
Sbjct: 1867 DTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHN- 1925
Query: 203 RSCQDVNECATENPCV---QTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLC- 258
C DV+ECA+ N + C+NT GSF C+C+ GYE+ DG C D++EC C
Sbjct: 1926 NDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCA 1985
Query: 259 QHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPI 318
C N G+Y C CPPGY L N C+DI+EC C L TC N +G FKC+ P
Sbjct: 1986 PGTCQNLDGSYRCICPPGYSL--QNEKCEDIDECVEEPEICAL-GTCSNTEGSFKCLCP- 2041
Query: 319 RCEEPYLRISDNRC 332
E L S RC
Sbjct: 2042 --EGFSLSSSGRRC 2053
Score = 171 bits (433), Expect = 1e-42
Identities = 109/367 (29%), Positives = 156/367 (42%), Gaps = 40/367 (10%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C PG + C +GF C+D++EC P C C N G ++C +
Sbjct: 1254 CTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGT-CENTKGSFIC--HCDMG 1310
Query: 76 YRGPYSNPYSTPYS----GPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDEC 131
Y G T + G + + + C G+ + + +C D+DEC
Sbjct: 1311 YSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFK--CSCSPGW-IGDGIKCTDLDEC 1367
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--RYGYCQQ-LCANVPGSY 188
+ +H C+ C NT G Y C C +GY C D+DEC C C N PG Y
Sbjct: 1368 SNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGY 1427
Query: 189 SCTCNPGFTLNEDGRSCQDVNECATENPCV-QTCVNTYGSFICRCDPGYELEEDGVHCSD 247
C C+ GF + DG++C+D++EC+ N CV TC N G F C C+ GYEL+ G +C+D
Sbjct: 1428 RCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487
Query: 248 MDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
++EC CVN PG+Y C CPP + L C D R+ C L
Sbjct: 1488 VNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDT-----RSGNCYLDIRPRG 1542
Query: 308 LQGGFKCIDPI-------------------RCEE-PYLRISDNRCMCPAENPGCRDQPFT 347
G C + I CE P + S+ + +CP G R P T
Sbjct: 1543 DNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPG-GEGFRPNPIT 1601
Query: 348 ILYRDMD 354
++ D+D
Sbjct: 1602 VILEDID 1608
Score = 171 bits (433), Expect = 1e-42
Identities = 121/338 (35%), Positives = 152/338 (44%), Gaps = 49/338 (14%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIP----- 70
C G+ + C G+ L Q+ +C DIDEC PE C C N G + C+
Sbjct: 1989 CQNLDGSYRCICPPGYSL--QNEKCEDIDECVEEPEICALGT-CSNTEGSFKCLCPEGFS 2045
Query: 71 -----------RTNPVYR----GPYSNPYSTPYSGPYPAAA--------PPLSAPNYPTI 107
R + Y G S+P S +S A P P P
Sbjct: 2046 LSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDE 2105
Query: 108 SRPLICRFGYQM--DESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ 165
+ IC +G + + VD+DEC + C Q CINT+G Y C C GY L +
Sbjct: 2106 AFRQICPYGSGIIVGPDDSAVDMDECK-EPDVCKHGQ-CINTDGSYRCECPFGYILAGNE 2163
Query: 166 CLDIDECRYGY-CQQ-LCANVPGSYSCTCNPGFTLNEDG--RSCQDVNECATENP--CVQ 219
C+D DEC G C C NV G + CTC GF E G +C+D+NECA +NP C
Sbjct: 2164 CVDTDECSVGNPCGNGTCKNVIGGFECTCEEGF---EPGPMMTCEDINECA-QNPLLCAF 2219
Query: 220 TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLC---QHECVNQPGTYFCSCPPG 276
CVNTYGS+ C+C GY L ED C D DEC + C Q EC N GTY C C PG
Sbjct: 2220 RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPG 2279
Query: 277 YILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
Y D C D NEC+ + C C N +G + C
Sbjct: 2280 YQRRPDGEGCVDENECQTKPGICE-NGRCLNTRGSYTC 2316
Score = 165 bits (418), Expect = 7e-41
Identities = 106/332 (31%), Positives = 154/332 (46%), Gaps = 40/332 (12%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL + G+ +C +GF +CLD E E V QN + NPV
Sbjct: 2307 CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTE--------VLQNMCQIGSSNRNPV 2358
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+ + GP+ P T++ +C G + D+DEC
Sbjct: 2359 TKSECCCDGGRGW-GPHCEI-----CPFQGTVAFKKLCPHGRGFMTNG--ADIDECKVIH 2410
Query: 136 HQCNPTQICINTEGGYTCSCTDGYW--LLEGQCLDIDECRYG--YCQQLCANVPGSYSCT 191
C + C+N G Y C C GY + C+D++EC C +C N GSY C+
Sbjct: 2411 DVCRNGE-CVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCS 2469
Query: 192 CNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C G+ L EDGRSC+D++ECAT ++ C CVNT G F C+C PG+ + C D +E
Sbjct: 2470 CPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF--TQHHTSCIDNNE 2527
Query: 251 CSFSEFLCQHE--CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
C+ LC + C N PG++ C C G+ L SC+D++ECE NH C Q C N+
Sbjct: 2528 CTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECE-GNHRC--QHGCQNI 2584
Query: 309 QGGFKCIDPIRCEEPYLR-------ISDNRCM 333
GG++C C + YL+ + +N C+
Sbjct: 2585 IGGYRC----SCPQGYLQHYQWNQCVDENECL 2612
Score = 162 bits (410), Expect = 6e-40
Identities = 86/231 (37%), Positives = 121/231 (52%), Gaps = 30/231 (12%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLEGQCLDID 170
C G+Q+D +C+DVDEC + + C + CIN +G YTC C GY L +C DID
Sbjct: 476 CNKGFQLDLRGECIDVDEC--EKNPCAGGE-CINNQGSYTCQCRAGYQSTLTRTECRDID 532
Query: 171 ECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYG 226
EC C C N GS+ C CN GF + DG++C+D++EC+ N C+ C+N G
Sbjct: 533 ECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDG 592
Query: 227 SFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSC 286
SF C C PG++L DG +C D++EC CVN G+Y C C PG + D R C
Sbjct: 593 SFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVC 652
Query: 287 QDINECEHRNHTCNLQQTCYNLQGGFK---CIDPIRCEEPYLRISDNRCMC 334
D +++ TCY GG+K CI P+ + ++ + C C
Sbjct: 653 VD----------THMRSTCY---GGYKRGQCIKPL-----FGAVTKSECCC 685
Score = 152 bits (383), Expect = 8e-37
Identities = 82/267 (30%), Positives = 118/267 (44%), Gaps = 50/267 (18%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C + G+ Q C G+ L C D+DEC T C+ +CVN GG+ C
Sbjct: 2458 ICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTC------ 2509
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
PP G+ ++ C+D +EC +D
Sbjct: 2510 --------------------KCPP-----------------GFTQHHTS-CIDNNECTSD 2531
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRYGY-CQQLCANVPGSYSCT 191
+ C IC NT G +TC C G+ L + C D+DEC + CQ C N+ G Y C+
Sbjct: 2532 INLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCS 2591
Query: 192 CNPGFTLNEDGRSCQDVNECATENPC-VQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C G+ + C D NEC + + C +C NT GS+ C C G++ E+ C D++E
Sbjct: 2592 CPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINE 2651
Query: 251 CSFSEFLCQHECVNQPGTYFCSCPPGY 277
C ++ C + C N G Y C CPPGY
Sbjct: 2652 CGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 149 bits (377), Expect = 4e-36
Identities = 104/339 (30%), Positives = 136/339 (40%), Gaps = 93/339 (27%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+P+PG+ + +C GF LD + G+C+D+DEC P C G C+N G Y C
Sbjct: 465 CIPTPGSCRCECNKGFQLDLR-GECIDVDECEKNP--CAGG-ECINNQGSYTC------- 513
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECATD 134
CR GYQ +C D+DEC +
Sbjct: 514 ------------------------------------QCRAGYQSTLTRTECRDIDECLQN 537
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDEC--RYGYCQQLCANVPGSYSC 190
CN + CINT+G + C C G+ + C D+DEC R +C N GS+ C
Sbjct: 538 GRICNNGR-CINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKC 596
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
C PGF L DGR C+D+NEC T C+ CVNT GS+ C C PG + DG C D
Sbjct: 597 ICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTH 656
Query: 250 E---------------------------CSFSEFLCQHECVNQPG------TYFCSCPPG 276
C+ +E+ C P CS PG
Sbjct: 657 MRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPG 716
Query: 277 YILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
+ DINEC C C NL+G +KCI
Sbjct: 717 M-----TSAGSDINECALDPDICP-NGICENLRGTYKCI 749
Score = 148 bits (374), Expect = 9e-36
Identities = 86/241 (35%), Positives = 114/241 (47%), Gaps = 14/241 (5%)
Query: 84 YSTPYSGPYPAAAP-PLSAPNYPTIS--RPLICRFGYQMDESNQCVDV---DECATDSHQ 137
Y P GP P P P P P I RP + + Y E + + V D C +
Sbjct: 401 YPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPV-EYLYPSREPPRVLPVNVTDYCQLVRYL 459
Query: 138 CNPTQICINTEGGYTCSCTDGYWL-LEGQCLDIDECRYGYCQQ-LCANVPGSYSCTCNPG 195
C + CI T G C C G+ L L G+C+D+DEC C C N GSY+C C G
Sbjct: 460 CQNGR-CIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCRAG 518
Query: 196 FTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEEDGVHCSDMDECSF 253
+ C+D++EC C+NT GSF C C+ G+ + DG +C DMDECS
Sbjct: 519 YQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSI 578
Query: 254 SEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFK 313
C+N+ G++ C C PG+ L D R C+DINECE N C N G ++
Sbjct: 579 RNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMN--GRCVNTDGSYR 636
Query: 314 C 314
C
Sbjct: 637 C 637
Score = 148 bits (373), Expect = 1e-35
Identities = 111/366 (30%), Positives = 157/366 (42%), Gaps = 49/366 (13%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ Q QC G+++ C+DI+EC P C C N +G Y CI
Sbjct: 1947 CINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGYS 2005
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDV------ 128
+ P A L + S +C G+ + S + C D+
Sbjct: 2006 LQNEKCEDIDECVEEPEICA---LGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCY 2062
Query: 129 -----DECATDSHQCNPTQIC---INTEG-GYTCS-------------CTDGYWLLEG-- 164
+C++ + + Q C + EG G C C G ++ G
Sbjct: 2063 AKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPD 2122
Query: 165 -QCLDIDECRY-GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-T 220
+D+DEC+ C+ C N GSY C C G+ L G C D +EC+ NPC T
Sbjct: 2123 DSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGT 2180
Query: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILL 280
C N G F C C+ G+E + C D++EC+ + LC CVN G+Y C CP GY+L
Sbjct: 2181 CKNVIGGFECTCEEGFE-PGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLR 2239
Query: 281 DDNRSCQDINECEHRNHTC-NLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
+D R C+D +ECE H C Q C NL G + CI C Y R D C EN
Sbjct: 2240 EDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI----CGPGYQRRPDGE-GCVDENE 2294
Query: 340 GCRDQP 345
C+ +P
Sbjct: 2295 -CQTKP 2299
Score = 131 bits (330), Expect = 1e-30
Identities = 92/338 (27%), Positives = 139/338 (41%), Gaps = 92/338 (27%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ C GF + R C D+DEC +I C MC+N++G + C
Sbjct: 546 CINTDGSFHCVCNAGFHVTRDGKNCEDMDEC-SIRNMCLNG-MCINEDGSFKC------- 596
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATD 134
IC+ G+Q+ + C D++EC T
Sbjct: 597 ------------------------------------ICKPGFQLASDGRYCKDINECETP 620
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWL-LEGQ-CLDI---DECRYGY------------- 176
N C+NT+G Y C C G + L+G+ C+D C GY
Sbjct: 621 GICMNGR--CVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAV 678
Query: 177 -----------------CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ 219
CQ A Y C+ G + G D+NECA +
Sbjct: 679 TKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG---SDINECALDPDICP 735
Query: 220 T--CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPG 276
C N G++ C C+ GYE++ G +C D++EC + LC + +C N PG++ C+CP G
Sbjct: 736 NGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKG 795
Query: 277 YILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
+I D ++C+DI+ECE + C + C N G F C
Sbjct: 796 FIYKPDLKTCEDIDECE--SSPC-INGVCKNSPGSFIC 830
Score = 128 bits (322), Expect = 9e-30
Identities = 106/369 (28%), Positives = 159/369 (43%), Gaps = 58/369 (15%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTN 73
A C+ + G+ + C G+ +GQC D +EC+ IP C C++ G + C+ T
Sbjct: 1822 AECINTAGSYRCDCKPGYRFT-STGQCNDRNECQEIPNICSHGQ-CIDTVGSFYCLCHTG 1879
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI-SRPLICRFGYQMDESNQCVDVDECA 132
++ + A + N TI S C G+ + +N C+DVDECA
Sbjct: 1880 --FKTNDDQTMCLDINECERDACGNGTCRN--TIGSFNCRCNHGFILSHNNDCIDVDECA 1935
Query: 133 TDSHQCNPTQICINTEGGYTCSCTDGYWLL-EGQ-CLDIDECRY---GYCQQLCANVPGS 187
+ + CINT G + C C +GY + +G+ C+DI+EC C N+ GS
Sbjct: 1936 SGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGS 1995
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATENP--CVQTCVNTYGSFICRCDPGYELEEDGVHC 245
Y C C PG++L + C+D++EC E + TC NT GSF C C G+ L G C
Sbjct: 1996 YRCICPPGYSLQNE--KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRC 2053
Query: 246 SD--MDEC-----------------SFSEFLCQHE----------CVNQPGTYFCS-CPP 275
D M C S E C + C +P F CP
Sbjct: 2054 QDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPY 2113
Query: 276 GY-ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCM- 333
G I++ + S D++EC+ + C Q C N G ++C C Y+ ++ N C+
Sbjct: 2114 GSGIIVGPDDSAVDMDECKEPD-VCKHGQ-CINTDGSYRC----ECPFGYI-LAGNECVD 2166
Query: 334 ---CPAENP 339
C NP
Sbjct: 2167 TDECSVGNP 2175
Score = 127 bits (320), Expect = 2e-29
Identities = 109/401 (27%), Positives = 150/401 (37%), Gaps = 80/401 (19%)
Query: 7 ILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGY 66
I + + +C+ G+ + C GF L C DI+EC T P C CVN +G Y
Sbjct: 578 IRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECET-PGICMNGR-CVNTDGSY 635
Query: 67 LC-----------------IPRTNPVYRGPYSNPYSTPYSGP------------YPAAAP 97
C + Y G P G Y P
Sbjct: 636 RCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEP 695
Query: 98 PLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTD 157
P + +C G M + D++ECA D C P IC N G Y C C
Sbjct: 696 CQPCPAQNSAEYQALCSSGPGMTSAGS--DINECALDPDIC-PNGICENLRGTYKCICNS 752
Query: 158 GYWL--LEGQCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECA 212
GY + C+DI+EC C C N PGS+ CTC GF D ++C+D++EC
Sbjct: 753 GYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECE 812
Query: 213 TENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSD-------------MDECSFSEFLC 258
+ +PC+ C N+ GSFIC C L+ C + E + +
Sbjct: 813 S-SPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATL 871
Query: 259 QHECVNQPGTYFCS----------CPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
+ +C + G + S C GY + + C+DI+ECE C C N
Sbjct: 872 KSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQ-CEDIDECEVFPGVCK-NGLCVNT 929
Query: 309 QGGFKCIDP--------------IRCEEPYLRISDNRCMCP 335
+G FKC P IR E +LR D C P
Sbjct: 930 RGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLP 970
Score = 126 bits (316), Expect = 5e-29
Identities = 110/358 (30%), Positives = 147/358 (41%), Gaps = 60/358 (16%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ + +C G+ L +C+D DEC ++ C G+ C N GG+ C
Sbjct: 2142 CINTDGSYRCECPFGYIL--AGNECVDTDEC-SVGNPC-GNGTCKNVIGGFECTCE---- 2193
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDESNQ-CVDVDECA 132
G P T A P L A S C GY + E + C D DEC
Sbjct: 2194 -EGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECE 2252
Query: 133 TDSHQCNPTQI-CINTEGGYTCSCTDGYWLL-EGQ-CLDIDECRY--GYCQQ-LCANVPG 186
H C Q+ C N G Y C C GY +G+ C+D +EC+ G C+ C N G
Sbjct: 2253 EGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRG 2312
Query: 187 SYSCTCNPGFTLNEDGRSCQDVNE--CATE---NPCV--QTCVNTYGSFICRCDPGYELE 239
SY+C CN GFT + + C D E C TE N C + N C CD G
Sbjct: 2313 SYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGG---R 2369
Query: 240 EDGVHC-------------------------SDMDECSFSEFLCQH-ECVNQPGTYFCSC 273
G HC +D+DEC +C++ ECVN G+Y C C
Sbjct: 2370 GWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCIC 2429
Query: 274 PPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR 331
GY SC D+NEC CN C N +G ++C C + Y+ D R
Sbjct: 2430 KTGYTPDITGTSCVDLNECNQAPKPCNF--ICKNTEGSYQC----SCPKGYILQEDGR 2481
Score = 121 bits (304), Expect = 1e-27
Identities = 100/334 (29%), Positives = 139/334 (41%), Gaps = 63/334 (18%)
Query: 39 QCLDIDECRTIPEACRGDMMCVNQNGGYLC-IP---------------RTNPVYRGPYSN 82
QC DIDEC P C+ + CVN G + C P R +
Sbjct: 907 QCEDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDE 965
Query: 83 PYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQ 142
+ P +G + A C G + +C + T ++ +
Sbjct: 966 ECTLPIAGRHRMDA--------------CCCSVGAAWG-TEECEECPMRNTPEYE----E 1006
Query: 143 ICINTEGGYTCSCTDGYWLLEGQCLDIDECRY--GYCQQ-LCANVPGSYSCTCNPGFTLN 199
+C G T T+G + DI+EC+ C C N GS+ C C+ GF L+
Sbjct: 1007 LCPRGPGFATKEITNGKPFFK----DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALD 1062
Query: 200 EDGRSCQDVNEC-ATENPCVQ-TCVNTYGSFICRCDPGYELEEDGV----HCSDMDECSF 253
+ R+C D++EC + + C + CVNT G F C+CD GY E G +C D+DEC
Sbjct: 1063 SEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY---ESGFMMMKNCMDIDECQR 1119
Query: 254 SEFLCQ-HECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGF 312
LC+ C N G+Y C CPPG+ L + +C DINECE H C C NL G +
Sbjct: 1120 DPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCP-NGRCVNLIGKY 1178
Query: 313 KCIDPIRCEEPYLRISDNR-CM----CPAENPGC 341
+C C Y D C+ C N GC
Sbjct: 1179 QC----ACNPGYHSTPDRLFCVDIDECSIMNGGC 1208
Score = 117 bits (293), Expect = 2e-26
Identities = 118/432 (27%), Positives = 169/432 (39%), Gaps = 100/432 (23%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGY--------- 66
C +PG+ C GF C DIDEC + P C + C N G +
Sbjct: 781 CRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSP--CINGV-CKNSPGSFICECSSEST 837
Query: 67 ------LCIPRTNPVY-------RGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLIC 113
+CI R + +T S + +P P IC
Sbjct: 838 LDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDP-IC 896
Query: 114 RFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL-LEGQ-CLDI-- 169
GY + QC D+DEC C +C+NT G + C C G L G+ CLDI
Sbjct: 897 GKGYSRIKGTQCEDIDECEVFPGVCK-NGLCVNTRGSFKCQCPSGMTLDATGRICLDIRL 955
Query: 170 DECRYGYCQQLCA-NVPGSY---SCTCN----------------------------PGFT 197
+ C Y + C + G + +C C+ PGF
Sbjct: 956 ETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFA 1015
Query: 198 LNE--DGRSC-QDVNECAT-ENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECS 252
E +G+ +D+NEC + C C NT GSF CRCD G+ L+ + +C+D+DEC
Sbjct: 1016 TKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECR 1075
Query: 253 FSEFLC-QHECVNQPGTYFCSCPPGY----ILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
S LC + +CVN PG + C C GY +++ ++C DI+EC+ C C+N
Sbjct: 1076 ISPDLCGRGQCVNTPGDFECKCDEGYESGFMMM---KNCMDIDECQRDPLLCR-GGVCHN 1131
Query: 308 LQGGFK---------------CIDPIRCEEPYLRISDNRCM-------CPAENPGCRDQP 345
+G ++ CID CE + RC+ C A NPG P
Sbjct: 1132 TEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQC-ACNPGYHSTP 1190
Query: 346 FTILYRDMDVVS 357
+ D+D S
Sbjct: 1191 DRLFCVDIDECS 1202
Score = 116 bits (290), Expect = 5e-26
Identities = 100/401 (24%), Positives = 146/401 (36%), Gaps = 86/401 (21%)
Query: 10 VTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC- 68
+ + C PG + +C G++LDR G C D++EC G+ CVN G Y+C
Sbjct: 1455 ICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGN--CVNTPGSYICD 1512
Query: 69 IP---RTNPVYRGPYSNPYSTPYSGPYPA-----------------------------AA 96
P NP G Y P
Sbjct: 1513 CPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGT 1572
Query: 97 PPLSAPNYPTISRPLICRFGYQMDESNQCV---DVDECATDSHQCNPTQICINTEGGYTC 153
P P T ++C G + V D+DEC C + CINT G + C
Sbjct: 1573 PCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGK-CINTFGSFQC 1631
Query: 154 SCTDGYWLLEGQ--CLDIDECRY-GYC-QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVN 209
C GY+L E C D++EC G C C N G+Y+C C P + G +C D+
Sbjct: 1632 RCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMR 1691
Query: 210 E---------------------------CATEN-------PCVQTCVNTYGSFICRCD-- 233
C + N PC Q + + F C
Sbjct: 1692 RSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQ 1751
Query: 234 -PGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
PG+ ++ D+DEC +C++ C+N G++ C CP G+ D C+DI+E
Sbjct: 1752 RPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDE 1811
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC 332
C++ C C N G ++C C+ Y S +C
Sbjct: 1812 CQN-GPVCQRNAECINTAGSYRC----DCKPGYRFTSTGQC 1847
Score = 105 bits (263), Expect = 6e-23
Identities = 106/403 (26%), Positives = 152/403 (37%), Gaps = 78/403 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + C G+ D + C D+DEC C G+ C+N GGY C
Sbjct: 1380 CKNTMGSYRCLCKEGYTGDGFT--CTDLDECSENLNLC-GNGQCLNAPGGYRC-----EC 1431
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPL----SAPNYPTISRPLICRFGYQMDESN-QCVDVDE 130
G + + P + + N P + R C GY++D S C DV+E
Sbjct: 1432 DMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFR-CECEIGYELDRSGGNCTDVNE 1490
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYC-----------QQ 179
C D C C+NT G Y C C + L + +D R G C
Sbjct: 1491 CL-DPTTCISGN-CVNTPGSYICDCPPDFELNPTRVGCVDT-RSGNCYLDIRPRGDNGDT 1547
Query: 180 LCANVPG----SYSCTCNPGFTLNEDGRSC---------------------------QDV 208
C+N G SC C+ G C +D+
Sbjct: 1548 ACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDI 1607
Query: 209 NECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQP 266
+EC Q C+NT+GSF CRC GY L ED C D++EC C N
Sbjct: 1608 DECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTV 1667
Query: 267 GTYFCSCPPGYILLDDNRSCQDINE--CEHRNHTCNLQQTC-----YNLQGGFKCID--- 316
G Y C CPP Y+ ++ +C D+ C +RN+ + QTC +N+ C
Sbjct: 1668 GNYTCICPPDYMQVNGGNNCMDMRRSLC-YRNYYAD-NQTCDGELLFNMTKKMCCCSYNI 1725
Query: 317 ----PIRCEE-PYLRISDNRCMCPAENPGCRDQPFTILYRDMD 354
CE+ P + +C ++ PG +T L D+D
Sbjct: 1726 GRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDID 1768
Score = 103 bits (256), Expect = 4e-22
Identities = 92/348 (26%), Positives = 135/348 (38%), Gaps = 101/348 (29%)
Query: 42 DIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSA 101
DIDEC+ +P C+G C+N G + C
Sbjct: 1606 DIDECQELPGLCQGG-KCINTFGSFQC--------------------------------- 1631
Query: 102 PNYPTISRPLICRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW 160
C GY ++E + C DV+EC T C P C NT G YTC C Y
Sbjct: 1632 ----------RCPTGYYLNEDTRVCDDVNECETPG-ICGP-GTCYNTVGNYTCICPPDYM 1679
Query: 161 LLEG--QCLDI-----------------DECRYGYCQQLCA---NVPGSYSCTC------ 192
+ G C+D+ E + +++C N+ +++ C
Sbjct: 1680 QVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIP 1739
Query: 193 ------------NPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICRCDPGYE 237
PGF ++ D++EC E P V C+N GSF C C G+
Sbjct: 1740 STDEFATLCGSQRPGFVIDIYTGLPVDIDEC-REIPGVCENGVCINMVGSFRCECPVGFF 1798
Query: 238 LEEDGVHCSDMDECSFSEFLCQH--ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
+ + C D+DEC +CQ EC+N G+Y C C PGY + C D NEC+
Sbjct: 1799 YNDKLLVCEDIDECQNGP-VCQRNAECINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEI 1856
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRD 343
+ C+ Q C + G F C+ C + + +D++ MC N RD
Sbjct: 1857 PNICSHGQ-CIDTVGSFYCL----CHTGF-KTNDDQTMCLDINECERD 1898
Score = 92.0 bits (227), Expect = 1e-18
Identities = 66/229 (28%), Positives = 94/229 (41%), Gaps = 28/229 (12%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC 172
C +G+ + + C T Q+C G C+ T C
Sbjct: 168 CTYGFTGPQCERDYRTGPCFT----VISNQMCQGQLSGIVCTKT--------LCCATVGR 215
Query: 173 RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ--TCVNTYGSFIC 230
+G+ ++C P C GF N +CQDV+EC Q C+NT GSF C
Sbjct: 216 AWGHPCEMCPAQPHP----CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFEC 271
Query: 231 RCDPGYELEEDGVHCSDMDECSFSEFLCQ-HECVNQPGTYFCSCPPGYILLDDNRSCQDI 289
+C G++L E C D+DECS +C+ EC N +YFC CPPG+ D C D+
Sbjct: 272 KCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Query: 290 NE----CEHRNHTCN--LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC 332
N C+ L Q+ +Q C D RC P + ++ C
Sbjct: 332 RPGYCYTALTNGRCSNQLPQSITKMQ---CCCDAGRCWSPGVTVAPEMC 377
Score = 60.8 bits (146), Expect = 2e-09
Identities = 47/181 (25%), Positives = 71/181 (39%), Gaps = 60/181 (33%)
Query: 27 CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYST 86
C GF + ++G C D+DEC+ IP C+G C+N G + C
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGG-NCINTVGSFEC------------------ 271
Query: 87 PYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDE-SNQCVDVDECATDSHQCNPTQICI 145
C G++++E S +C D+DEC+T C + C
Sbjct: 272 -------------------------KCPAGHKLNEVSQKCEDIDECSTIPGICEGGE-CT 305
Query: 146 NTEGGYTCSCTDGYWLLEG--QCLDIDECRYGYCQQLCAN------VPGSYS---CTCNP 194
NT Y C C G++ +C+D+ R GYC N +P S + C C+
Sbjct: 306 NTVSSYFCKCPPGFYTSPDGTRCIDV---RPGYCYTALTNGRCSNQLPQSITKMQCCCDA 362
Query: 195 G 195
G
Sbjct: 363 G 363
Score = 45.8 bits (107), Expect = 8e-05
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
C+ + G+ + +C G L+ S +C DIDEC TIP C G C N Y C
Sbjct: 262 CINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGG-ECTNTVSSYFC 313
Score = 42.4 bits (98), Expect = 9e-04
Identities = 21/55 (38%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
A C + G+ + C GF ++ SG C DI+EC + C C N GGYLC
Sbjct: 2620 ASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPC--SYGCSNTEGGYLC 2672
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 181 bits (460), Expect = 9e-46
Identities = 108/311 (34%), Positives = 145/311 (46%), Gaps = 18/311 (5%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ C GF LD Q C DIDECR P+ C G CVN G + C P
Sbjct: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFEC--ECFPG 1058
Query: 76 YRGPY---SNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDEC 131
Y + N P + N S C G+++ + C D+DEC
Sbjct: 1059 YESGFMLMKNCMDVDECARDPLLCRGGTCTNTDG-SYKCQCPPGHELTAKGTACEDIDEC 1117
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPGS 187
+ C P C+N G + CSC G+ + C+DI+ECR G C C N GS
Sbjct: 1118 SLSDGLC-PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATENP--CVQT-CVNTYGSFICRCDPGYELEEDGVH 244
Y C+C G++L DGR+C DV+EC ENP C Q C N G C C G+ D
Sbjct: 1177 YRCSCGQGYSLMPDGRACADVDECE-ENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRT 1235
Query: 245 CSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQ 303
C D+DEC + +C H +C N G++ C C GY++ C D++ECE H C+
Sbjct: 1236 CVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHA 1295
Query: 304 TCYNLQGGFKC 314
+C N+ G F C
Sbjct: 1296 SCLNIPGSFSC 1306
Score = 175 bits (443), Expect = 9e-44
Identities = 103/337 (30%), Positives = 142/337 (42%), Gaps = 60/337 (17%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ S G+ + C G+ D + CLD+DEC +P+ C +C N G +LC
Sbjct: 2379 CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCS------ 2430
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATD 134
C GY ++E + C D+DEC +
Sbjct: 2431 -------------------------------------CPRGYLLEEDGRTCKDLDECTSR 2453
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--RYGYC--QQLCANVPGSYSC 190
H C +C+NT G +TC C G+ C D DEC + G C C N PGS+ C
Sbjct: 2454 QHNCQ--FLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC 2511
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 250
C+ GFTL G C+DVNEC + C C N G + C C G+ C D +E
Sbjct: 2512 ECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE 2571
Query: 251 CSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQ 309
C+ S C C N G + C CP G+ CQ+++EC R C+ +C N
Sbjct: 2572 CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCS--YSCANTP 2629
Query: 310 GGFKCIDPIRCEEPYLRISDNRCMCP-AENPGCRDQP 345
GGF C C + Y R C+ +PG +D P
Sbjct: 2630 GGFLC----GCPQGYFRAGQGHCVSGLGFSPGPQDTP 2662
Score = 166 bits (420), Expect = 4e-41
Identities = 112/393 (28%), Positives = 169/393 (43%), Gaps = 62/393 (15%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDI-----------DECR-TIPEACRGDMMCVNQN 63
C+ + G+ + +C G LD C+D+ DEC T+P R D+ C +
Sbjct: 885 CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG 944
Query: 64 GGYLCIPRTNPVYRGPYSNPYSTPYSGPYP-----AAAPPLSA-PNYPTISRPLI----- 112
+ P +P S ++ P A+ LS P Y ++ +
Sbjct: 945 AVWGVECEACP-------DPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC 997
Query: 113 ---------------CRFGYQMD-ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCT 156
C G+ +D + C D+DEC C C+NT G + C C
Sbjct: 998 THGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECF 1056
Query: 157 DGY---WLLEGQCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNE 210
GY ++L C+D+DEC C+ C N GSY C C PG L G +C+D++E
Sbjct: 1057 PGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDE 1116
Query: 211 CA-TENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGT 268
C+ ++ C CVN G+F C C G++ D C D++EC C C+N G+
Sbjct: 1117 CSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
Query: 269 YFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRIS 328
Y CSC GY L+ D R+C D++ECE C+ Q C N+ GG +C+ C + ++
Sbjct: 1177 YRCSCGQGYSLMPDGRACADVDECEENPRVCD-QGHCTNMPGGHRCL----CYDGFMATP 1231
Query: 329 DNRCMCPAENPGCRDQPFTILYRDMDVVSGRSV 361
D R + C P L+ D + G V
Sbjct: 1232 DMRTCVDVDE--CDLNPHICLHGDCENTKGSFV 1262
Score = 159 bits (403), Expect = 4e-39
Identities = 106/347 (30%), Positives = 149/347 (42%), Gaps = 57/347 (16%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C+ G+ + +C GF+ + C D+DEC + C+ + C+N G Y C
Sbjct: 1736 ICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC------ 1789
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--------SRPLICRFGYQMD-ESNQC 125
+ Y G PN + S +C G+Q + C
Sbjct: 1790 ----KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLC 1845
Query: 126 VDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLL-EGQCLDIDE--------CRYGY 176
+D+DEC D C C N G Y C C G+ + G C+D DE CR+G+
Sbjct: 1846 MDIDEC--DRQPCG-NGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGH 1902
Query: 177 CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNEC-ATENPCVQ-TCVNTYGSFICRCDP 234
C N GS+ C C GF L DG++C D NEC + C+ TC N GSF C C P
Sbjct: 1903 ----CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPP 1958
Query: 235 GYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECE 293
G++++ D HC D+DECS LC C N PG++ C CPPG++L D+ C D
Sbjct: 1959 GFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR--- 2013
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPG 340
Q C+ KC P + RC C ++ PG
Sbjct: 2014 --------QSFCFTRFEAGKCSVP-----KAFNTTKTRCCC-SKRPG 2046
Score = 159 bits (402), Expect = 5e-39
Identities = 97/282 (34%), Positives = 132/282 (46%), Gaps = 16/282 (5%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEAC-RGDMMCVNQNGGYLCIPRTNP 74
C PG + C +GF C+D+DEC P C GD C N G ++C +
Sbjct: 1212 CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD--CENTKGSFVCHCQLGY 1269
Query: 75 VYRGPY---SNPYSTPYSGPY-PAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDE 130
+ R S+ G + A L+ P S C G+ + + +C D+DE
Sbjct: 1270 MVRKGATGCSDVDECEVGGHNCDSHASCLNIPG----SFSCRCLPGW-VGDGFECHDLDE 1324
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--RYGYCQQ-LCANVPGS 187
C + H+C+P C+N G Y C+C G+ C D DEC C C N PG
Sbjct: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGG 1384
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATENPCV-QTCVNTYGSFICRCDPGYELEEDGVHCS 246
Y C C GF ED R+CQDV+ECA N C +C N G F C C+ GYEL+ G +C+
Sbjct: 1385 YRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCT 1444
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
D++EC+ C+N PG+Y CSCP + L C D
Sbjct: 1445 DINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVD 1486
Score = 158 bits (399), Expect = 1e-38
Identities = 113/343 (32%), Positives = 150/343 (43%), Gaps = 64/343 (18%)
Query: 18 PSPGNAQAQCTN---GFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
P + Q C N GF D +G+ LDIDEC IP C + C+NQ G + C
Sbjct: 1694 PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGI-CINQIGSFRC------ 1746
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
PA NY +I C DVDEC +
Sbjct: 1747 ----------------ECPAGF------NYNSILLA--------------CEDVDECGSR 1770
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG-QCLDIDECRY--GYCQQL-CANVPGSYSC 190
C CIN G Y C CT GY L G C+ +ECR C C + GSY C
Sbjct: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMC 1830
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
C+ GF + D C D++EC PC TC N GS+ C C PG+ + +G C D D
Sbjct: 1831 LCHRGFQASADQTLCMDIDEC-DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNG-DCVDFD 1888
Query: 250 EC-SFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
EC + +C+ C+N G++ C C G+ L D ++C D NEC TC L TC N
Sbjct: 1889 ECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTC-LPGTCQN 1947
Query: 308 LQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILY 350
L+G F+CI P P ++ + C+ E C ++P L+
Sbjct: 1948 LEGSFRCICP-----PGFQVQSDHCIDIDE---CSEEPNLCLF 1982
Score = 157 bits (396), Expect = 2e-38
Identities = 101/314 (32%), Positives = 137/314 (43%), Gaps = 23/314 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ + C G+ L C D+DEC P C C N GG+ C+
Sbjct: 1170 CINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVC-DQGHCTNMPGGHRCL-----C 1223
Query: 76 YRGPYSNPYSTPYSGPYPAAAPP---LSAPNYPTISRPLI-CRFGYQMDE-SNQCVDVDE 130
Y G + P P L T + C+ GY + + + C DVDE
Sbjct: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG-QCLDIDEC--RYGYCQQL--CANVP 185
C H C+ C+N G ++C C G W+ +G +C D+DEC + C C NVP
Sbjct: 1284 CEVGGHNCDSHASCLNIPGSFSCRCLPG-WVGDGFECHDLDECVSQEHRCSPRGDCLNVP 1342
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEEDGV 243
GSY CTC GF DG C+D +ECA C+N G + C C+ G++ ED
Sbjct: 1343 GSYRCTCRQGFA--GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHR 1400
Query: 244 HCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQ 303
C D+DEC+ C N PG + C C GY L +C DINEC + N
Sbjct: 1401 ACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCIN--G 1458
Query: 304 TCYNLQGGFKCIDP 317
C N G + C P
Sbjct: 1459 VCINTPGSYLCSCP 1472
Score = 152 bits (383), Expect = 8e-37
Identities = 80/198 (40%), Positives = 106/198 (53%), Gaps = 13/198 (6%)
Query: 127 DVDECATDSHQCNPTQICINTEGGYTCSCTDGYW--LLEGQCLDIDECRY--GYCQQLCA 182
DVDEC +H C + CIN+ G + C C GY CLD+DEC C LC
Sbjct: 2363 DVDECRMLAHLCAHGE-CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCK 2421
Query: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEED 241
N GS+ C+C G+ L EDGR+C+D++EC + ++ C CVNT G+F CRC PG+
Sbjct: 2422 NTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQ 2481
Query: 242 GVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTC 299
C D DECS C C N PG++ C C G+ L+ C+D+NEC+ H C
Sbjct: 2482 A--CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRC 2538
Query: 300 NLQQTCYNLQGGFKCIDP 317
Q C N GG++C P
Sbjct: 2539 --QHGCQNQLGGYRCSCP 2554
Score = 145 bits (367), Expect = 6e-35
Identities = 82/235 (34%), Positives = 110/235 (46%), Gaps = 26/235 (11%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDID 170
C GY D +C+DVDEC S C+ C+N G Y C C G+ + C+D+D
Sbjct: 435 CNVGYTQDVRGECIDVDECT--SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVD 491
Query: 171 ECRY--GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYG 226
EC G C C N GS+ C CN GF L+ DG++C D NECAT CV C+N G
Sbjct: 492 ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDG 551
Query: 227 SFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSC 286
SF C C PG+ L G +C D+DEC C N G++ C C G + D R C
Sbjct: 552 SFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
Query: 287 QDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYL-RISDNRCMCPAENPG 340
D +++ TCY I+ C P+ ++ + C C + G
Sbjct: 612 VD----------THVRSTCYG------AIEKGSCARPFPGTVTKSECCCANPDHG 650
Score = 143 bits (361), Expect = 3e-34
Identities = 72/196 (36%), Positives = 102/196 (52%), Gaps = 9/196 (4%)
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL-LEGQCLDIDECRYGYCQQL- 180
NQ +D+ C ++ C + C+ T Y C C GY + G+C+D+DEC C
Sbjct: 406 NQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD 462
Query: 181 CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYEL 238
C N+PG+Y C C PGF ++C DV+EC CVNT GSF C C+ G+EL
Sbjct: 463 CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
Query: 239 EEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHT 298
DG +C D +EC+ S C+N+ G++ C C PG++L C DI+EC+
Sbjct: 523 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGIC 582
Query: 299 CNLQQTCYNLQGGFKC 314
N C N +G F+C
Sbjct: 583 VN--GHCTNTEGSFRC 596
Score = 140 bits (353), Expect = 2e-33
Identities = 109/386 (28%), Positives = 163/386 (42%), Gaps = 59/386 (15%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL + G+ C +GF+L C+D +EC ++ C C N G + CI P
Sbjct: 1903 CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGT-CQNLEGSFRCI--CPPG 1959
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDE--CA 132
++ + P + N P S +C G+ + D ++C D + C
Sbjct: 1960 FQVQSDHCIDIDECSEEPNLCLFGTCTNSPG-SFQCLCPPGFVLSDNGHRCFDTRQSFCF 2018
Query: 133 T--DSHQCNPTQICINTEGGYTCS-------------------------CTDGYWLLEG- 164
T ++ +C+ + T+ CS C G+ + G
Sbjct: 2019 TRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGP 2078
Query: 165 --QCLDIDECRY--GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ 219
D++EC G C +C N GS+ C C G++L+ G +C D +EC+ +PC Q
Sbjct: 2079 DDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQ 2138
Query: 220 -TCVNTYGSFICRCDPGYELEEDGVH--CSDMDECSFSEFLCQHECVNQPGTYFCSCPPG 276
TC N G F C C G+E G+ C D+DECS + LC C N G+Y C+CP G
Sbjct: 2139 GTCTNVIGGFECACADGFE---PGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAG 2195
Query: 277 YILLDDNRSCQDINECEHRNHTCNLQ-QTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCP 335
Y L +D C+D++EC C+ + C NL G F C+ P P +R P
Sbjct: 2196 YTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP-----PGMR------PLP 2244
Query: 336 AENPGCRDQPFTILYRDMDVVSGRSV 361
GC D D+ V+GR V
Sbjct: 2245 GSGEGCTDDNECHAQPDL-CVNGRCV 2269
Score = 137 bits (345), Expect = 2e-32
Identities = 107/346 (30%), Positives = 152/346 (43%), Gaps = 57/346 (16%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEAC-RGDMMCVNQNGGYLCIPRTNP 74
C+ PG+ + +CT G+ L G C+ +ECR IP C GD C++ G Y+C+
Sbjct: 1780 CINIPGSYRCKCTRGYKLS-PGGACVGRNECREIPNVCSHGD--CMDTEGSYMCL----- 1831
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDESNQCVDVDECA 132
+RG ++ T P I S +C G+ + + CVD DEC
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECT 1891
Query: 133 TDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDEC--RYGYC-QQLCANVPGS 187
T Q C+NT G + C C DG+ L C+D +EC G C C N+ GS
Sbjct: 1892 TLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGS 1951
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATE-NPCV-QTCVNTYGSFICRCDPGYELEEDGVHC 245
+ C C PGF + D C D++EC+ E N C+ TC N+ GSF C C PG+ L ++G C
Sbjct: 1952 FRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
Query: 246 SD-----------MDECS----FSEFLCQHECVNQPGTYF---CS-------------CP 274
D +CS F+ + C +PG + C CP
Sbjct: 2010 FDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCP 2069
Query: 275 PGYILL---DDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
G+ + DD+R +D+NEC C C N G F+C P
Sbjct: 2070 FGHGAVPGPDDSR--EDVNECAENPGVCT-NGVCVNTDGSFRCECP 2112
Score = 134 bits (336), Expect = 2e-31
Identities = 106/385 (27%), Positives = 155/385 (40%), Gaps = 106/385 (27%)
Query: 13 LALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRT 72
L C+ + G+ Q C GF+L C+D +EC T G +C+N++G + C+
Sbjct: 502 LGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNG--VCLNEDGSFSCL--- 556
Query: 73 NPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDEC 131
C+ G+ + C+D+DEC
Sbjct: 557 ----------------------------------------CKPGFLLAPGGHYCMDIDEC 576
Query: 132 ATDSHQCNPTQICINTEGGYTCSC-------TDG------------YWLLE-GQC----- 166
T N C NTEG + C C TDG Y +E G C
Sbjct: 577 QTPGICVNGH--CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFP 634
Query: 167 --LDIDEC-------RYGYCQQLC-ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATE-N 215
+ EC +G QLC A + C+ G + DGR D+NECA +
Sbjct: 635 GTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPE 691
Query: 216 PCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSC 273
C C N GS+ C C+ GYE G C+D+DEC+ + LC + C N PG+Y CSC
Sbjct: 692 VCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSC 751
Query: 274 PPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC-------IDP--IRCEEP- 323
PPG+ D C+D++EC + C + C NL G + C +DP C +
Sbjct: 752 PPGFHFWQDTEICKDVDEC--LSSPC-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDST 808
Query: 324 ----YLRISDNRCMCPAENPGCRDQ 344
+L+I ++RC + R +
Sbjct: 809 KGTCWLKIQESRCEVNLQGASLRSE 833
Score = 133 bits (334), Expect = 4e-31
Identities = 78/268 (29%), Positives = 107/268 (39%), Gaps = 51/268 (19%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
LC + G+ C G+ L+ C D+DEC + C+ +CVN G + C
Sbjct: 2419 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTC------ 2470
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
PP G+ C D DEC+
Sbjct: 2471 --------------------RCPP-----------------GF-TQHHQACFDNDECSAQ 2492
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGY-CQQLCANVPGSYSCT 191
C C NT G + C C G+ L+ C D++EC + CQ C N G Y C+
Sbjct: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCS 2552
Query: 192 CNPGFTLNEDGRSCQDVNECATENPCV--QTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
C GFT + C D NECA P +C NT G F C C G++ ++ C ++D
Sbjct: 2553 CPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVD 2612
Query: 250 ECSFSEFLCQHECVNQPGTYFCSCPPGY 277
EC+ C + C N PG + C CP GY
Sbjct: 2613 ECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
Score = 126 bits (317), Expect = 3e-29
Identities = 100/338 (29%), Positives = 131/338 (38%), Gaps = 91/338 (26%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CLP+P + + +C G+ D + G+C+D+DEC + P GD CVN G Y C
Sbjct: 424 CLPTPSSYRCECNVGYTQDVR-GECIDVDECTSSP-CHHGD--CVNIPGTYHC------- 472
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ-CVDVDECATD 134
C G+Q + Q CVDVDEC
Sbjct: 473 ------------------------------------RCYPGFQATPTRQACVDVDECIVS 496
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYG--YCQQLCANVPGSYSC 190
C+ + C+NTEG + C C G+ L C+D +EC +C N GS+SC
Sbjct: 497 GGLCHLGR-CVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSC 555
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSD-- 247
C PGF L G C D++EC T CV C NT GSF C+C G + DG C D
Sbjct: 556 LCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH 615
Query: 248 -----------------------MDEC-------SFSEFLCQHECVNQPGTYFCSCPPGY 277
EC F E CQ + C G
Sbjct: 616 VRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGE-PCQLCPAKDSAEFQALCSSGL 674
Query: 278 ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
+ D R DINEC C C NL+G ++C+
Sbjct: 675 GITTDGR---DINECALDPEVC-ANGVCENLRGSYRCV 708
Score = 126 bits (316), Expect = 5e-29
Identities = 108/396 (27%), Positives = 149/396 (37%), Gaps = 80/396 (20%)
Query: 9 TVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
T+ + +CL G+ C GF L C+DIDEC+T G C N G + C
Sbjct: 539 TMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH--CTNTEGSFRC 596
Query: 69 -------------------IPRT--NPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI 107
+ T + +G + P+ + A P P
Sbjct: 597 QCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ 656
Query: 108 SRPL--------ICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGY 159
P +C G + + D++ECA D C +C N G Y C C GY
Sbjct: 657 LCPAKDSAEFQALCSSGLGITTDGR--DINECALDPEVC-ANGVCENLRGSYRCVCNLGY 713
Query: 160 WLLEG--QCLDIDECRYG--YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATE 214
C D+DEC C C N PGSYSC+C PGF +D C+DV+EC +
Sbjct: 714 EAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLS- 772
Query: 215 NPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDE----CSFSEFLCQ---------H 260
+PCV C N GS+ C+C PG L+ G C D + E C+
Sbjct: 773 SPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRS 832
Query: 261 ECVNQPGTYFCS----------CPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQG 310
EC G + S C G+ + +C D+NECE C C N G
Sbjct: 833 ECCATLGAAWGSPCERCEIDPACARGFARM-TGVTCDDVNECESFPGVCP-NGRCVNTAG 890
Query: 311 GFKCIDP--------------IRCEEPYLRISDNRC 332
F+C P +R E +LR ++ C
Sbjct: 891 SFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC 926
Score = 125 bits (315), Expect = 6e-29
Identities = 107/374 (28%), Positives = 141/374 (37%), Gaps = 66/374 (17%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C G + C +GF+ C DIDEC P C C N G YLC
Sbjct: 2141 CTNVIGGFECACADGFEPGLMM-TCEDIDECSLNPLLCA--FRCHNTEGSYLCTCPAGYT 2197
Query: 76 YR--GPYSNPYSTPYSGPYPAAAPPLSAPNY--------PTISRPLICRFGYQMDESNQC 125
R G G A + N P RPL C
Sbjct: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPL-------PGSGEGC 2250
Query: 126 VDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW-------------------LLEGQC 166
D +EC C + C+NT G + C C +G+ +L+ C
Sbjct: 2251 TDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMC 2309
Query: 167 LDID---------EC------RYGYCQQLCANVPGS--YSCTCNPGFTLNEDGRSCQDVN 209
+ EC +G +LC +PG+ Y C G +GR DV+
Sbjct: 2310 RSLSSSSEAVTRAECCCGGGRGWGPRCELCP-LPGTSAYRKLCPHGSGYTAEGR---DVD 2365
Query: 210 ECAT-ENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPG 267
EC + C C+N+ GSF C C GY + C DMDECS C C N G
Sbjct: 2366 ECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKG 2425
Query: 268 TYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRI 327
++ CSCP GY+L +D R+C+D++EC R H C Q C N G F C P + +
Sbjct: 2426 SFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC--QFLCVNTVGAFTCRCPPGFTQHHQAC 2483
Query: 328 SDNRCMCPAENPGC 341
DN C A+ C
Sbjct: 2484 FDND-ECSAQPGPC 2496
Score = 116 bits (290), Expect = 5e-26
Identities = 98/341 (28%), Positives = 131/341 (38%), Gaps = 92/341 (26%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C+ + G+ + +C G+ LD C+D DEC ++ C G C N GG+ C
Sbjct: 2099 VCVNTDGSFRCECPFGYSLDFTGINCVDTDEC-SVGHPC-GQGTCTNVIGGFECA----- 2151
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
C G++ C D+DEC+ +
Sbjct: 2152 --------------------------------------CADGFEPGLMMTCEDIDECSLN 2173
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRYGY--CQQL---CANVPGS 187
C C NTEG Y C+C GY L E C D+DEC G C C N+ G+
Sbjct: 2174 PLLC--AFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGT 2231
Query: 188 YSCTCNPGFT-LNEDGRSCQDVNEC-ATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244
++C C PG L G C D NEC A + CV CVNT GSF C CD G++
Sbjct: 2232 FACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTE 2291
Query: 245 CSDMDE---------------CSFSEFLCQHEC--------------VNQPGT--YFCSC 273
C D+ + S SE + + EC PGT Y C
Sbjct: 2292 CHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLC 2351
Query: 274 PPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
P G + R D++EC H C C N G F+C
Sbjct: 2352 PHGSGYTAEGR---DVDECRMLAHLC-AHGECINSLGSFRC 2388
Score = 114 bits (285), Expect = 2e-25
Identities = 98/333 (29%), Positives = 127/333 (38%), Gaps = 58/333 (17%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRT--N 73
CL PG+ + C GF D C D DEC + C C+N GGY C +
Sbjct: 1338 CLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENVDLCDNGQ-CLNAPGGYRCECEMGFD 1394
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESN-QCVDVDECA 132
P G A S N P + R IC GY++D C D++ECA
Sbjct: 1395 PTEDHRACQDVDECAQGNLCAFG---SCENLPGMFR-CICNGGYELDRGGGNCTDINECA 1450
Query: 133 TDSHQCNPTQICINTEGGYTCSCTDGYWL----------LEGQC---------------- 166
+ N +CINT G Y CSC + L G C
Sbjct: 1451 DPVNCING--VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSA 1508
Query: 167 -LDIDECRYGYCQQL-------CANVPGSYS------CTCNPGFTLNEDGRSCQDVNECA 212
+ + R C L C P + + C GF N +D++EC
Sbjct: 1509 EIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ 1568
Query: 213 TENPCVQ--TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLC-QHECVNQPGTY 269
Q CVNT+GSF C C PGY L E C D+DECS +C C N G Y
Sbjct: 1569 ELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY 1628
Query: 270 FCSCPPGYILLDDNRSCQDINEC---EHRNHTC 299
C CP Y+ ++ +C D+ + H N TC
Sbjct: 1629 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTC 1661
Score = 108 bits (270), Expect = 1e-23
Identities = 103/407 (25%), Positives = 145/407 (35%), Gaps = 89/407 (21%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYL-------- 67
C PG + C G++LDR G C DI+EC G +C+N G YL
Sbjct: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING--VCINTPGSYLCSCPQDFE 1476
Query: 68 ---------------CIPRTNPVYRGPYSNPYSTPYSGPYPAAA-----------PPLSA 101
C T+ RG S A+ P
Sbjct: 1477 LNPSGVGCVDTRAGNCFLETHD--RGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELC 1534
Query: 102 PNYPTISRPLICRFGYQMDESNQCV---DVDECATDSHQCNPTQICINTEGGYTCSCTDG 158
P T +C G + V D+DEC C C+NT G + C C G
Sbjct: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD-CVNTFGSFQCECPPG 1593
Query: 159 YWLLEGQ--CLDIDEC--RYGYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECAT 213
Y L E C DIDEC G C C N G+Y+C C + G +C D+ +
Sbjct: 1594 YHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVC 1653
Query: 214 ENPCVQTCVNTYGSFICR----------------CD-------PGYEL----EEDG---- 242
TC N + R C+ P Y++ + G
Sbjct: 1654 FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTD 1713
Query: 243 VHCS---DMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHT 298
+H D+DEC +C + C+NQ G++ C CP G+ +C+D++EC R
Sbjct: 1714 IHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESP 1773
Query: 299 CNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQP 345
C C N+ G ++C +C Y C+ E CR+ P
Sbjct: 1774 CQQNADCINIPGSYRC----KCTRGYKLSPGGACVGRNE---CREIP 1813
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/180 (25%), Positives = 65/180 (36%), Gaps = 40/180 (22%)
Query: 145 INTEGGYTCSCTDGYWLLEGQCLDIDECRYGY---------CQQLCAN---VPGSYSCTC 192
++ G + SC +G CL C+ GY C + C N G C C
Sbjct: 114 VSRGSGCSVSCMNGGTCRGASCL----CQKGYTGTVCGQPICDRGCHNGGRCIGPNRCAC 169
Query: 193 NPGFT----------------LNEDGRSCQDVNECATENPCVQTCVNTYG--SFICRCDP 234
GF + +G Q T+ C T +G +C P
Sbjct: 170 VYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQP 229
Query: 235 -----GYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQD 288
G+ C D+DEC LCQ CVN G++ C CP G+ L D + +C+D
Sbjct: 230 HPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289
Score = 43.1 bits (100), Expect = 5e-04
Identities = 58/252 (23%), Positives = 88/252 (34%), Gaps = 51/252 (20%)
Query: 108 SRPLICRFGYQMD-ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQC 166
++P CR G+ + + C DVDEC C C+N G + C C G+ L +
Sbjct: 227 AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSSA 285
Query: 167 LDIDECRYGYCQQL-----CA-NVPGSYS---CTCNPG--FTLNEDGRSCQDVNECATEN 215
++ R G C + CA ++ G Y+ C C+ G + C +
Sbjct: 286 A-CEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
Query: 216 PCVQTC-----------------------------VNTYGS---FICRCDPGYELEEDGV 243
C Q +N +GS I PG
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
Query: 244 HCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQ 302
+D C LC + C+ P +Y C C GY D C D++EC + C+
Sbjct: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY-TQDVRGECIDVDEC--TSSPCH-H 460
Query: 303 QTCYNLQGGFKC 314
C N+ G + C
Sbjct: 461 GDCVNIPGTYHC 472
Score = 42.4 bits (98), Expect = 9e-04
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
A C + G + C +GFD D+ G C ++DEC C C N GG+LC
Sbjct: 2582 ASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC--SYSCANTPGGFLC 2634
Score = 41.2 bits (95), Expect = 0.002
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 27 CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
C GF + +G C D+DEC+ +P C+G CVN G + C
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGG-SCVNMVGSFHC 272
Score = 40.0 bits (92), Expect = 0.004
Identities = 54/206 (26%), Positives = 74/206 (35%), Gaps = 43/206 (20%)
Query: 153 CSCTDGYWLLEGQCLDIDECRYGYCQQLCAN--VPGSYSCTCNPGFTLNEDG-----RSC 205
C+C DG L C R C C N SC C G+T G R C
Sbjct: 101 CTCADG--TLAPSC---GVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGC 155
Query: 206 QDVNECATENPCVQTCVNTYGSFICRCDPGYEL--------------EEDGVHCSDMDEC 251
+ C N C CV YG +C+ Y + G+ C+ C
Sbjct: 156 HNGGRCIGPNRCA--CV--YGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC 211
Query: 252 SF---SEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
+ + L C QP C G+I +CQD++EC+ C +C N+
Sbjct: 212 ATVGRAWGLPCELCPAQPHP----CRRGFIPNIHTGACQDVDECQAVPGLCQ-GGSCVNM 266
Query: 309 QGGFKCIDPIRCEEPYLRISDNRCMC 334
G F C RC + R+SD+ C
Sbjct: 267 VGSFHC----RCPVGH-RLSDSSAAC 287
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 179 bits (454), Expect = 5e-45
Identities = 118/389 (30%), Positives = 164/389 (42%), Gaps = 80/389 (20%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL +PG C GF L C D+DEC CR CVN G Y C+P P
Sbjct: 3458 CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGP- 3516
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
G+++ + C DVDEC
Sbjct: 3517 ----------------------------------------GFRVADGAGCEDVDECLEGL 3536
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQ---CLDIDECRY--GYCQQLCANVPGSYSC 190
C+ Q+C NT GG+ CSC GY ++G CLD++EC C C N+ GSY C
Sbjct: 3537 DDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 3595
Query: 191 TCNPGFTLNEDGRSC-------QDVNECATENPCVQTCV-------NTYGSFICR----- 231
C PG TL DG++C Q+V + P + +Y +++
Sbjct: 3596 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3655
Query: 232 ---------CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDD 282
C PG+ + ++GV C+D+DEC LCQH C N G+Y C CP GY LL
Sbjct: 3656 ALSSVGRAWCPPGF-IRQNGV-CTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 3712
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMCPAENPGC 341
++CQDINECE + C Q C+N +G ++C+D C Y + S C
Sbjct: 3713 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVD-TPCPATYRQGPSPGTCFRRCSQDCG 3771
Query: 342 RDQPFTILYRDMDVVSGRSVPADIFQMQA 370
P T+ YR + + G D+ ++ A
Sbjct: 3772 TGGPSTLQYRLLPLPLGVRAHHDVARLTA 3800
Score = 128 bits (321), Expect = 1e-29
Identities = 72/175 (41%), Positives = 94/175 (53%), Gaps = 16/175 (9%)
Query: 155 CTDGYWLLEGQ---CLDIDECRYGY--CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVN 209
C +G+ L + Q C+D DEC G C C N PG +SCTC GF L D R+C+DV+
Sbjct: 3428 CPEGFEL-DSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 3486
Query: 210 ECATENPCV---QTCVNTYGSFICR--CDPGYELEEDGVHCSDMDECSFSEFLCQHE--C 262
ECA + Q CVN GS+ C C PG+ + DG C D+DEC C + C
Sbjct: 3487 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLC 3545
Query: 263 VNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
N PG + CSCP GY + + C D+NEC C Q C+NLQG ++C+ P
Sbjct: 3546 ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCP 3598
Score = 126 bits (316), Expect = 5e-29
Identities = 72/202 (35%), Positives = 103/202 (50%), Gaps = 22/202 (10%)
Query: 113 CRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDI 169
C G+++D CVD DEC+ C+ C+N G ++C+C G+ L + C D+
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCS--HACLNAPGRFSCTCPTGFALAWDDRNCRDV 3485
Query: 170 DECRYG--YCQ--QLCANVPGSYSCT--CNPGFTLNEDGRSCQDVNECATE-NPCV--QT 220
DEC + C+ Q C N+ GSY C C PGF + DG C+DV+EC + C Q
Sbjct: 3486 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQL 3544
Query: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILL 280
C NT G C C GY ++ + C D++EC C ++C N G+Y C CPPG LL
Sbjct: 3545 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 3604
Query: 281 DDNRSC-------QDINECEHR 295
D ++C Q++ HR
Sbjct: 3605 RDGKACTSLERNGQNVTTVSHR 3626
Score = 92.8 bits (229), Expect = 6e-19
Identities = 42/112 (37%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
C G+EL+ G C D DECS C H C+N PG + C+CP G+ L D+R+C+D++E
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3487
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRD 343
C H C Q C NL G ++C+ P R++D GC D
Sbjct: 3488 CAWDAHLCREGQRCVNLLGSYRCLPDC---GPGFRVAD--------GAGCED 3528
Score = 79.3 bits (194), Expect = 6e-15
Identities = 61/211 (28%), Positives = 85/211 (40%), Gaps = 37/211 (17%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR--- 71
LC +PG + C G+ + S CLD++EC +P+AC C N G Y C+
Sbjct: 3544 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACA--YQCHNLQGSYRCLCPPGQ 3601
Query: 72 -------------------TNPVYRGP---YSNPYSTPYSGPYPAAAPPLSAPNYPTISR 109
T +RGP + P+++ Y A P +
Sbjct: 3602 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 3661
Query: 110 PLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCL 167
C G+ + ++ C D+DEC + C C NTEG Y C C GY LL C
Sbjct: 3662 RAWCPPGF-IRQNGVCTDLDECRV-RNLCQ--HACRNTEGSYQCLCPAGYRLLPSGKNCQ 3717
Query: 168 DIDECRYGYCQ----QLCANVPGSYSCTCNP 194
DI+EC + Q+C N GSY C P
Sbjct: 3718 DINECEEESIECGPGQMCFNTRGSYQCVDTP 3748
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 179 bits (454), Expect = 5e-45
Identities = 118/389 (30%), Positives = 164/389 (42%), Gaps = 80/389 (20%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL +PG C GF L C D+DEC CR CVN G Y C+P P
Sbjct: 4649 CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGP- 4707
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
G+++ + C DVDEC
Sbjct: 4708 ----------------------------------------GFRVADGAGCEDVDECLEGL 4727
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQ---CLDIDECRY--GYCQQLCANVPGSYSC 190
C+ Q+C NT GG+ CSC GY ++G CLD++EC C C N+ GSY C
Sbjct: 4728 DDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 4786
Query: 191 TCNPGFTLNEDGRSC-------QDVNECATENPCVQTCV-------NTYGSFICR----- 231
C PG TL DG++C Q+V + P + +Y +++
Sbjct: 4787 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 4846
Query: 232 ---------CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDD 282
C PG+ + ++GV C+D+DEC LCQH C N G+Y C CP GY LL
Sbjct: 4847 ALSSVGRAWCPPGF-IRQNGV-CTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 4903
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMCPAENPGC 341
++CQDINECE + C Q C+N +G ++C+D C Y + S C
Sbjct: 4904 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVD-TPCPATYRQGPSPGTCFRRCSQDCG 4962
Query: 342 RDQPFTILYRDMDVVSGRSVPADIFQMQA 370
P T+ YR + + G D+ ++ A
Sbjct: 4963 TGGPSTLQYRLLPLPLGVRAHHDVARLTA 4991
Score = 128 bits (321), Expect = 1e-29
Identities = 72/175 (41%), Positives = 94/175 (53%), Gaps = 16/175 (9%)
Query: 155 CTDGYWLLEGQ---CLDIDECRYGY--CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVN 209
C +G+ L + Q C+D DEC G C C N PG +SCTC GF L D R+C+DV+
Sbjct: 4619 CPEGFEL-DSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 4677
Query: 210 ECATENPCV---QTCVNTYGSFICR--CDPGYELEEDGVHCSDMDECSFSEFLCQHE--C 262
ECA + Q CVN GS+ C C PG+ + DG C D+DEC C + C
Sbjct: 4678 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLC 4736
Query: 263 VNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
N PG + CSCP GY + + C D+NEC C Q C+NLQG ++C+ P
Sbjct: 4737 ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCP 4789
Score = 126 bits (316), Expect = 5e-29
Identities = 72/202 (35%), Positives = 103/202 (50%), Gaps = 22/202 (10%)
Query: 113 CRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDI 169
C G+++D CVD DEC+ C+ C+N G ++C+C G+ L + C D+
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCS--HACLNAPGRFSCTCPTGFALAWDDRNCRDV 4676
Query: 170 DECRYG--YCQ--QLCANVPGSYSCT--CNPGFTLNEDGRSCQDVNECATE-NPCV--QT 220
DEC + C+ Q C N+ GSY C C PGF + DG C+DV+EC + C Q
Sbjct: 4677 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQL 4735
Query: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILL 280
C NT G C C GY ++ + C D++EC C ++C N G+Y C CPPG LL
Sbjct: 4736 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 4795
Query: 281 DDNRSC-------QDINECEHR 295
D ++C Q++ HR
Sbjct: 4796 RDGKACTSLERNGQNVTTVSHR 4817
Score = 92.8 bits (229), Expect = 6e-19
Identities = 42/112 (37%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
C G+EL+ G C D DECS C H C+N PG + C+CP G+ L D+R+C+D++E
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 4678
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRD 343
C H C Q C NL G ++C+ P R++D GC D
Sbjct: 4679 CAWDAHLCREGQRCVNLLGSYRCLPDC---GPGFRVAD--------GAGCED 4719
Score = 79.3 bits (194), Expect = 6e-15
Identities = 61/211 (28%), Positives = 85/211 (40%), Gaps = 37/211 (17%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR--- 71
LC +PG + C G+ + S CLD++EC +P+AC C N G Y C+
Sbjct: 4735 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACA--YQCHNLQGSYRCLCPPGQ 4792
Query: 72 -------------------TNPVYRGP---YSNPYSTPYSGPYPAAAPPLSAPNYPTISR 109
T +RGP + P+++ Y A P +
Sbjct: 4793 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 4852
Query: 110 PLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCL 167
C G+ + ++ C D+DEC + C C NTEG Y C C GY LL C
Sbjct: 4853 RAWCPPGF-IRQNGVCTDLDECRV-RNLCQ--HACRNTEGSYQCLCPAGYRLLPSGKNCQ 4908
Query: 168 DIDECRYGYCQ----QLCANVPGSYSCTCNP 194
DI+EC + Q+C N GSY C P
Sbjct: 4909 DINECEEESIECGPGQMCFNTRGSYQCVDTP 4939
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 179 bits (454), Expect = 5e-45
Identities = 118/389 (30%), Positives = 164/389 (42%), Gaps = 80/389 (20%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
CL +PG C GF L C D+DEC CR CVN G Y C+P P
Sbjct: 3367 CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGP- 3425
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
G+++ + C DVDEC
Sbjct: 3426 ----------------------------------------GFRVADGAGCEDVDECLEGL 3445
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQ---CLDIDECRY--GYCQQLCANVPGSYSC 190
C+ Q+C NT GG+ CSC GY ++G CLD++EC C C N+ GSY C
Sbjct: 3446 DDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 3504
Query: 191 TCNPGFTLNEDGRSC-------QDVNECATENPCVQTCV-------NTYGSFICR----- 231
C PG TL DG++C Q+V + P + +Y +++
Sbjct: 3505 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3564
Query: 232 ---------CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDD 282
C PG+ + ++GV C+D+DEC LCQH C N G+Y C CP GY LL
Sbjct: 3565 ALSSVGRAWCPPGF-IRQNGV-CTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 3621
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMCPAENPGC 341
++CQDINECE + C Q C+N +G ++C+D C Y + S C
Sbjct: 3622 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVD-TPCPATYRQGPSPGTCFRRCSQDCG 3680
Query: 342 RDQPFTILYRDMDVVSGRSVPADIFQMQA 370
P T+ YR + + G D+ ++ A
Sbjct: 3681 TGGPSTLQYRLLPLPLGVRAHHDVARLTA 3709
Score = 128 bits (321), Expect = 1e-29
Identities = 72/175 (41%), Positives = 94/175 (53%), Gaps = 16/175 (9%)
Query: 155 CTDGYWLLEGQ---CLDIDECRYGY--CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVN 209
C +G+ L + Q C+D DEC G C C N PG +SCTC GF L D R+C+DV+
Sbjct: 3337 CPEGFEL-DSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 3395
Query: 210 ECATENPCV---QTCVNTYGSFICR--CDPGYELEEDGVHCSDMDECSFSEFLCQHE--C 262
ECA + Q CVN GS+ C C PG+ + DG C D+DEC C + C
Sbjct: 3396 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLC 3454
Query: 263 VNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
N PG + CSCP GY + + C D+NEC C Q C+NLQG ++C+ P
Sbjct: 3455 ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHNLQGSYRCLCP 3507
Score = 126 bits (316), Expect = 5e-29
Identities = 72/202 (35%), Positives = 103/202 (50%), Gaps = 22/202 (10%)
Query: 113 CRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDI 169
C G+++D CVD DEC+ C+ C+N G ++C+C G+ L + C D+
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCS--HACLNAPGRFSCTCPTGFALAWDDRNCRDV 3394
Query: 170 DECRYG--YCQ--QLCANVPGSYSCT--CNPGFTLNEDGRSCQDVNECATE-NPCV--QT 220
DEC + C+ Q C N+ GSY C C PGF + DG C+DV+EC + C Q
Sbjct: 3395 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQL 3453
Query: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILL 280
C NT G C C GY ++ + C D++EC C ++C N G+Y C CPPG LL
Sbjct: 3454 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 3513
Query: 281 DDNRSC-------QDINECEHR 295
D ++C Q++ HR
Sbjct: 3514 RDGKACTSLERNGQNVTTVSHR 3535
Score = 92.8 bits (229), Expect = 6e-19
Identities = 42/112 (37%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
C G+EL+ G C D DECS C H C+N PG + C+CP G+ L D+R+C+D++E
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3396
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRD 343
C H C Q C NL G ++C+ P R++D GC D
Sbjct: 3397 CAWDAHLCREGQRCVNLLGSYRCLPDC---GPGFRVAD--------GAGCED 3437
Score = 79.3 bits (194), Expect = 6e-15
Identities = 61/211 (28%), Positives = 85/211 (40%), Gaps = 37/211 (17%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR--- 71
LC +PG + C G+ + S CLD++EC +P+AC C N G Y C+
Sbjct: 3453 LCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACA--YQCHNLQGSYRCLCPPGQ 3510
Query: 72 -------------------TNPVYRGP---YSNPYSTPYSGPYPAAAPPLSAPNYPTISR 109
T +RGP + P+++ Y A P +
Sbjct: 3511 TLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVG 3570
Query: 110 PLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCL 167
C G+ + ++ C D+DEC + C C NTEG Y C C GY LL C
Sbjct: 3571 RAWCPPGF-IRQNGVCTDLDECRV-RNLCQ--HACRNTEGSYQCLCPAGYRLLPSGKNCQ 3626
Query: 168 DIDECRYGYCQ----QLCANVPGSYSCTCNP 194
DI+EC + Q+C N GSY C P
Sbjct: 3627 DINECEEESIECGPGQMCFNTRGSYQCVDTP 3657
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 176 bits (447), Expect = 3e-44
Identities = 117/335 (34%), Positives = 151/335 (45%), Gaps = 22/335 (6%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+P P + C G+ Q C+D++EC P G +C+N G Y C N
Sbjct: 590 CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNC--HCNRG 646
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRP----LICRFGYQMDESNQ--CVDVD 129
YR + A P L I+ P C GY++ S C D+D
Sbjct: 647 YR-LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
Query: 130 ECATDSHQCNPTQICINTEGGYTC-SCTDGYWLLEG-QCLDIDECRYGY-CQQ-LCANVP 185
EC D C P C N G + C +C GY G C D++EC G C C N+P
Sbjct: 706 ECR-DPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244
GS+ CTC G+ DGRSC DV+EC + C C NT GSF C+C GY L D H
Sbjct: 764 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSH 823
Query: 245 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 304
C D+DEC F +C+N G+Y C CP G+ L+ R CQDI+EC C
Sbjct: 824 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA 882
Query: 305 CYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
C NLQG + C+ C+E + D E P
Sbjct: 883 CKNLQGSYVCV----CDEGFTPTQDQHGCEEVEQP 913
Score = 113 bits (282), Expect = 4e-25
Identities = 97/385 (25%), Positives = 145/385 (37%), Gaps = 110/385 (28%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C +PG+ Q QC +G+ L R C DIDEC P AC G C+N NG Y C+
Sbjct: 799 ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGD-CINTNGSYRCL----- 851
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
C G+++ +C D+DEC+ D
Sbjct: 852 --------------------------------------CPQGHRLVGGRKCQDIDECSQD 873
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDID------ECRYG-----YCQQLC 181
C P C N +G Y C C +G+ + Q C +++ EC +C +
Sbjct: 874 PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVL 933
Query: 182 ANVPGSYSCTCNPG--------------------FTLNEDGR--------------SCQD 207
A C C+ G +L DG+ + +D
Sbjct: 934 ATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRD 993
Query: 208 VNEC---ATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQH-ECV 263
++EC +E CVNT + C C G+ + + + C D+DEC E C++ C
Sbjct: 994 IDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCE 1052
Query: 264 NQPGTYFCSCPPGYILLDDNRSC-----QDINECEHRNHTCNLQQTCYNLQGGFKCIDPI 318
N G Y C+C P R C D++EC+ + C NL G ++C
Sbjct: 1053 NTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ--DPAACRPGRCVNLPGSYRC---- 1106
Query: 319 RCEEPYLRISDNR-CMCPAENPGCR 342
C P++ R C P E+P R
Sbjct: 1107 ECRPPWVPGPSGRDCQLP-ESPAER 1130
Score = 101 bits (252), Expect = 1e-21
Identities = 73/193 (37%), Positives = 90/193 (46%), Gaps = 39/193 (20%)
Query: 165 QCLDIDECRYGYCQQLCAN---VPG--SYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ 219
Q + DECR Q +C + VPG YSC CNPG+ + R C DVNEC E PC
Sbjct: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGP 627
Query: 220 ---TCVNTYGSFICRCDPGYELE--EDGVHCSDMDECSFSEFLCQHE--CVNQPGTYFCS 272
C+NT GS+ C C+ GY L G C D++EC+ LC C+N PG Y C+
Sbjct: 628 GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCN 686
Query: 273 CPPGYILLDDNRS-CQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR 331
C PGY L C+DI+EC R+ + C N G FKCI
Sbjct: 687 CYPGYRLKASRPPVCEDIDEC--RDPSSCPDGKCENKPGSFKCI---------------- 728
Query: 332 CMCPAENPGCRDQ 344
A PG R Q
Sbjct: 729 ----ACQPGYRSQ 737
Score = 93.6 bits (231), Expect = 3e-19
Identities = 78/269 (28%), Positives = 101/269 (37%), Gaps = 72/269 (26%)
Query: 113 CRFGYQMDESN-QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG--YWLLEGQCL-- 167
C+ G+ D + +CVDVDEC +S+ N +C NT GGY C+CT Y + QCL
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNG--VCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
Query: 168 ---DIDECRY-GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP------ 216
D+DEC+ C+ C N+PGSY C C P + GR CQ A P
Sbjct: 1079 EEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVC 1138
Query: 217 ---------CVQTCVN---TYGSFICRCDPGYELE-------EDGVHC------------ 245
C T+ CR G+ + G HC
Sbjct: 1139 WSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1198
Query: 246 -----------------SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
D DEC CV +PG C CP G+ L C D
Sbjct: 1199 TSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVD 1254
Query: 289 INECEHRNHTCNL--QQTCYNLQGGFKCI 315
I+EC N L + C N G F+C+
Sbjct: 1255 IDECRELNQRGLLCKSERCVNTSGSFRCV 1283
Score = 70.5 bits (171), Expect = 3e-12
Identities = 80/333 (24%), Positives = 114/333 (34%), Gaps = 107/333 (32%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + + C GF D +C+D+DEC + E+ + +C N GGY C
Sbjct: 1010 CVNTQPGYECYCKQGFYYDGNLLECVDVDEC--LDESNCRNGVCENTRGGYRC------- 1060
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
A PP Y R + S + +DVDEC D
Sbjct: 1061 ------------------ACTPP---AEYSPAQRQCL---------SPEEMDVDEC-QDP 1089
Query: 136 HQCNPTQICINTEGGYTCSC--------------------------TDGYWL-------- 161
C P + C+N G Y C C D W
Sbjct: 1090 AACRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC 1148
Query: 162 ---LEGQCLDIDE--CRYG-----YCQQLCANVPGSYSCTCNP-------------GFTL 198
L G L D+ CR G C+ GS+ T G
Sbjct: 1149 AGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPP 1208
Query: 199 NEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDEC---SFS 254
++ S +D +EC CV CV G +C C G++L+ C D+DEC +
Sbjct: 1209 RDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
Query: 255 EFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSC 286
LC+ E CVN G++ C C G+ + +C
Sbjct: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
Score = 51.6 bits (122), Expect = 1e-06
Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 15/104 (14%)
Query: 194 PGFTLNEDGRSCQDVNECATENPC----------VQTCVNTYGSFICRCDPGYELEEDGV 243
PG T ED C + ++ C VQ G C GY+ +
Sbjct: 295 PGLTKQED--CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNST 351
Query: 244 HCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286
HC D++EC+ +C+H +C+N PG+Y C CPPG+ L C
Sbjct: 352 HCQDINECAMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 42.7 bits (99), Expect = 7e-04
Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 12/99 (12%)
Query: 149 GGYTCSCTDGYWLLEG-QCLDIDECRY-GYCQQL-CANVPGSYSCTCNPGFTLNEDGRSC 205
G C GY L C DI+EC G C+ C N PGSY C C PG +L C
Sbjct: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Query: 206 -----QDVNEC----ATENPCVQTCVNTYGSFICRCDPG 235
++ + C + E+ C +C C G
Sbjct: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 37.7 bits (86), Expect = 0.021
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 23/117 (19%)
Query: 234 PGYELEEDGVHCSDMDECSFSEFLCQHEC-------VNQPGTYF----CSCPPGYILLDD 282
PG +ED C ++ + C H+C V +PG CP GY L+
Sbjct: 295 PGLTKQED---CCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
CQDINEC C C N G ++C+ P P + +R C A+ P
Sbjct: 351 TH-CQDINECAMPG-VCR-HGDCLNNPGSYRCVCP-----PGHSLGPSRTQCIADKP 399
Score = 35.4 bits (80), Expect = 0.11
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL 161
C GY+ S C D++ECA C C+N G Y C C G+ L
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCVCPPGHSL 387
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 176 bits (447), Expect = 3e-44
Identities = 117/335 (34%), Positives = 151/335 (45%), Gaps = 22/335 (6%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+P P + C G+ Q C+D++EC P G +C+N G Y C N
Sbjct: 590 CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNC--HCNRG 646
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRP----LICRFGYQMDESNQ--CVDVD 129
YR + A P L I+ P C GY++ S C D+D
Sbjct: 647 YR-LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
Query: 130 ECATDSHQCNPTQICINTEGGYTC-SCTDGYWLLEG-QCLDIDECRYGY-CQQ-LCANVP 185
EC D C P C N G + C +C GY G C D++EC G C C N+P
Sbjct: 706 ECR-DPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVH 244
GS+ CTC G+ DGRSC DV+EC + C C NT GSF C+C GY L D H
Sbjct: 764 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSH 823
Query: 245 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 304
C D+DEC F +C+N G+Y C CP G+ L+ R CQDI+EC C
Sbjct: 824 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGA 882
Query: 305 CYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
C NLQG + C+ C+E + D E P
Sbjct: 883 CKNLQGSYVCV----CDEGFTPTQDQHGCEEVEQP 913
Score = 106 bits (265), Expect = 4e-23
Identities = 88/344 (25%), Positives = 132/344 (38%), Gaps = 83/344 (24%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C +PG+ Q QC +G+ L R C DIDEC P AC G C+N NG Y C+
Sbjct: 799 ICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGD-CINTNGSYRCL----- 851
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
C G+++ +C D+DEC+ D
Sbjct: 852 --------------------------------------CPQGHRLVGGRKCQDIDECSQD 873
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDID------ECRYG-----YCQQLC 181
C P C N +G Y C C +G+ + Q C +++ EC +C +
Sbjct: 874 PSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVL 933
Query: 182 ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEED 241
A C C+ G G C+ PC + S +C GY + +
Sbjct: 934 ATNVTQQECCCSLGAGW---GDHCEIY-------PCPVYSSAEFHS-LCPDGKGYTQDNN 982
Query: 242 GVHCS-----DMDECSF--SEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEH 294
V+ D+DEC SE + +CVN Y C C G+ + C D++EC
Sbjct: 983 IVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLD 1042
Query: 295 RNHTCNLQQTCYNLQGGFKCIDPIRCEEP-YLRISDNRCMCPAE 337
++ N C N +GG++C C P + +C+ P E
Sbjct: 1043 ESNCRN--GVCENTRGGYRC----ACTPPAEYSPAQRQCLSPEE 1080
Score = 101 bits (252), Expect = 1e-21
Identities = 73/193 (37%), Positives = 90/193 (46%), Gaps = 39/193 (20%)
Query: 165 QCLDIDECRYGYCQQLCAN---VPG--SYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ 219
Q + DECR Q +C + VPG YSC CNPG+ + R C DVNEC E PC
Sbjct: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGP 627
Query: 220 ---TCVNTYGSFICRCDPGYELE--EDGVHCSDMDECSFSEFLCQHE--CVNQPGTYFCS 272
C+NT GS+ C C+ GY L G C D++EC+ LC C+N PG Y C+
Sbjct: 628 GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCN 686
Query: 273 CPPGYILLDDNRS-CQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR 331
C PGY L C+DI+EC R+ + C N G FKCI
Sbjct: 687 CYPGYRLKASRPPVCEDIDEC--RDPSSCPDGKCENKPGSFKCI---------------- 728
Query: 332 CMCPAENPGCRDQ 344
A PG R Q
Sbjct: 729 ----ACQPGYRSQ 737
Score = 82.4 bits (202), Expect = 8e-16
Identities = 94/403 (23%), Positives = 128/403 (31%), Gaps = 110/403 (27%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYL-------- 67
C+ + G+ + C G L +C DIDEC P C C N G Y+
Sbjct: 841 CINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT 899
Query: 68 -------CIPRTNPVYRGP-YSNPYSTPYSGPYPAA------------------APPLSA 101
C P ++ Y N T + A
Sbjct: 900 PTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPC 959
Query: 102 PNYPTISRPLICRFGYQMDESNQCV--------DVDECATDSHQCNPTQICINTEGGYTC 153
P Y + +C G + N V D+DEC + C+NT+ GY C
Sbjct: 960 PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
Query: 154 SCTDGYW----LLEGQCLDIDECR-YGYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQD 207
C G++ LLE C+D+DEC C+ +C N G Y C C P + R C
Sbjct: 1020 YCKQGFYYDGNLLE--CVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
Query: 208 VNE----------CATENPCVQTCVN-------TYGSFICRCDPGYELE-------EDGV 243
E C ++ C T+ CR G+ + G
Sbjct: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS 1137
Query: 244 HC-----------------------------SDMDECSFSEFLCQHECVNQPGTYFCSCP 274
HC D DEC CV +PG C CP
Sbjct: 1138 HCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECP 1193
Query: 275 PGYILLDDNRSCQDINECEHRNHTCNL--QQTCYNLQGGFKCI 315
G+ L C DI+EC N L + C N G F+C+
Sbjct: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
Score = 69.7 bits (169), Expect = 5e-12
Identities = 61/236 (25%), Positives = 88/236 (37%), Gaps = 68/236 (28%)
Query: 113 CRFGYQMDESN-QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG--YWLLEGQCLDI 169
C+ G+ D + +CVDVDEC +S+ N +C NT GGY C+CT Y + QCL
Sbjct: 1021 CKQGFYYDGNLLECVDVDECLDESNCRNG--VCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
Query: 170 DECRY---------------GYC-----------QQLCANVPGSYSCTCNP--------- 194
+E G C C + C P
Sbjct: 1079 EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH 1138
Query: 195 -------------------GFTLNEDGRSCQDVNECATENPCVQ-TCVNTYGSFICRCDP 234
G ++ S +D +EC CV CV G +C C
Sbjct: 1139 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPG 1194
Query: 235 GYELEEDGVHCSDMDEC---SFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSC 286
G++L+ C D+DEC + LC+ E CVN G++ C C G+ + +C
Sbjct: 1195 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/211 (27%), Positives = 78/211 (36%), Gaps = 30/211 (14%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNG--GYLCIPRT 72
+C + G + CT + QCL +E PE R D +C +Q G G P
Sbjct: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPE--RRD-VCWSQRGEDGMCAGPLA 1106
Query: 73 NPVY----------RGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDES 122
P RG + P G S N + PL+ DE
Sbjct: 1107 GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLG-KPPRDED 1165
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRY-----G 175
+ D DEC S +C P GG C C G+ L +C+DIDECR
Sbjct: 1166 SSEEDSDECRCVSGRCVP------RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGL 1219
Query: 176 YCQ-QLCANVPGSYSCTCNPGFTLNEDGRSC 205
C+ + C N GS+ C C GF + +C
Sbjct: 1220 LCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 51.6 bits (122), Expect = 1e-06
Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 15/104 (14%)
Query: 194 PGFTLNEDGRSCQDVNECATENPC----------VQTCVNTYGSFICRCDPGYELEEDGV 243
PG T ED C + ++ C VQ G C GY+ +
Sbjct: 295 PGLTKQED--CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNST 351
Query: 244 HCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286
HC D++EC+ +C+H +C+N PG+Y C CPPG+ L C
Sbjct: 352 HCQDINECAMPG-VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 42.7 bits (99), Expect = 7e-04
Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 12/99 (12%)
Query: 149 GGYTCSCTDGYWLLEG-QCLDIDECRY-GYCQQL-CANVPGSYSCTCNPGFTLNEDGRSC 205
G C GY L C DI+EC G C+ C N PGSY C C PG +L C
Sbjct: 335 GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Query: 206 -----QDVNEC----ATENPCVQTCVNTYGSFICRCDPG 235
++ + C + E+ C +C C G
Sbjct: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 37.7 bits (86), Expect = 0.021
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 23/117 (19%)
Query: 234 PGYELEEDGVHCSDMDECSFSEFLCQHEC-------VNQPGTYF----CSCPPGYILLDD 282
PG +ED C ++ + C H+C V +PG CP GY L+
Sbjct: 295 PGLTKQED---CCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
CQDINEC C C N G ++C+ P P + +R C A+ P
Sbjct: 351 TH-CQDINECAMPG-VCR-HGDCLNNPGSYRCVCP-----PGHSLGPSRTQCIADKP 399
Score = 35.4 bits (80), Expect = 0.11
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL 161
C GY+ S C D++ECA C C+N G Y C C G+ L
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCVCPPGHSL 387
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 176 bits (445), Expect = 5e-44
Identities = 132/483 (27%), Positives = 202/483 (41%), Gaps = 103/483 (21%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ C G+ L + +C+D++ECR CR D C N GGY CI
Sbjct: 5206 CFNAIGSFHCGCEPGYQL--KGRKCMDVNECRQ--NVCRPDQHCKNTRGGYKCID----- 5256
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+C G E+ C+D+DEC +
Sbjct: 5257 ------------------------------------LCPNGMTKAENGTCIDIDECKDGT 5280
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRY--GYCQQLCANVPGSYSCT 191
HQC QIC NT G Y C C GY + C+DI+EC C C+N PGS+ C
Sbjct: 5281 HQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCI 5340
Query: 192 CNPGFTLNEDGRSCQDVN------------ECATENPC---------VQTCVNTYGSF-- 228
C PG L DG+SC + A +P + + Y S+
Sbjct: 5341 CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSE 5400
Query: 229 -------ICR--------CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSC 273
+ R C G E D C D+DEC ++ CQHEC N G+Y C C
Sbjct: 5401 YRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENTD-ACQHECKNTFGSYQCIC 5457
Query: 274 PPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRIS-DNRC 332
PPGY L + ++CQDI+EC +N C + C+N++G ++CID C Y R C
Sbjct: 5458 PPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCID-TPCPPNYQRDPVSGFC 5516
Query: 333 M--CPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYY---IFQIKSGN 387
+ CP + C P+ + Y+ + + G + D+ ++ A T+ G + F +
Sbjct: 5517 LKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQ-DGVMHPRTTFLMVDEE 5575
Query: 388 EGREFYMRQTGPISATLVMTRPIKGPR--EIQLDLEMITVNTVINFRGSSVIRLRIYVSQ 445
+ F +R + + TRP++ +++ + N I ++ + ++ I VS
Sbjct: 5576 QTVPFALRDEN-LKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIV--YIAVSA 5632
Query: 446 YPF 448
YP+
Sbjct: 5633 YPY 5635
Score = 152 bits (383), Expect = 8e-37
Identities = 87/217 (40%), Positives = 111/217 (51%), Gaps = 19/217 (8%)
Query: 113 CRFGYQMDESNQ-CVDVDECATDSHQCNP-TQICINTEGGYTCSCTDGYWL-LEGQ-CLD 168
C G+ +D C D DECA NP + C N G Y CSC G + +G+ C D
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG----NPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147
Query: 169 IDECRYG----YCQQLCANVPGSYSCT--CNPGFTLNEDGRSCQDVNECATENPCVQTCV 222
IDEC G + Q C N GSY C C GF DG SCQD+NEC +PC Q C
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCF 5207
Query: 223 NTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC--SCPPGYILL 280
N GSF C C+PGY+L+ G C D++EC + C N G Y C CP G +
Sbjct: 5208 NAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNG-MTK 5264
Query: 281 DDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
+N +C DI+EC+ H C Q C N +G ++C+ P
Sbjct: 5265 AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCP 5301
Score = 150 bits (378), Expect = 3e-36
Identities = 108/310 (34%), Positives = 126/310 (40%), Gaps = 62/310 (20%)
Query: 19 SPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRG 78
S G+ QC +GF LD C D DEC C N G Y C
Sbjct: 5084 SKGDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHS---CHNAMGTYYC---------- 5130
Query: 79 PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQC 138
S P TI+ + C D+DECA H C
Sbjct: 5131 ---------------------SCPKGLTIAA-----------DGRTCQDIDECALGRHTC 5158
Query: 139 NPTQICINTEGGYTC--SCTDGYWLLEG--QCLDIDECRYGY-CQQLCANVPGSYSCTCN 193
+ Q C NT G Y C C G+ C DI+EC+ C Q C N GS+ C C
Sbjct: 5159 HAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCE 5218
Query: 194 PGFTLNEDGRSCQDVNECATENPC--VQTCVNTYGSFIC--RCDPGYELEEDGVHCSDMD 249
PG+ L GR C DVNEC +N C Q C NT G + C C G E+G C D+D
Sbjct: 5219 PGYQLK--GRKCMDVNEC-RQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT-CIDID 5274
Query: 250 ECSFSEFLCQHE--CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
EC C++ C N G+Y C CP GY R C DINECE C Q C N
Sbjct: 5275 ECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSN 5332
Query: 308 LQGGFKCIDP 317
G FKCI P
Sbjct: 5333 TPGSFKCICP 5342
Score = 140 bits (354), Expect = 2e-33
Identities = 91/300 (30%), Positives = 122/300 (40%), Gaps = 55/300 (18%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G C G + C DIDEC C C N G Y C+ R
Sbjct: 5121 CHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSG 5180
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+R + + C D++EC +S
Sbjct: 5181 FR----------------------------------------RTSDGLSCQDINECQ-ES 5199
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQ--QLCANVPGSYSCT-- 191
C+ Q C N G + C C GY L +C+D++ECR C+ Q C N G Y C
Sbjct: 5200 SPCH--QRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDL 5257
Query: 192 CNPGFTLNEDGRSCQDVNECAT-ENPCV--QTCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C G T E+G +C D++EC + C Q C NT GS+ C C GY + G C D+
Sbjct: 5258 CPNGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDI 5316
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
+EC C H+C N PG++ C CPPG LL D +SC + R Q + YNL
Sbjct: 5317 NECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGL----ERLPNYGTQYSSYNL 5372
Score = 107 bits (266), Expect = 3e-23
Identities = 58/152 (38%), Positives = 76/152 (50%), Gaps = 12/152 (7%)
Query: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHC 245
G S C GFTL+ G C D +ECA NPC +C N G++ C C G + DG C
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145
Query: 246 SDMDECSFSEFLCQ--HECVNQPGTYFC--SCPPGYILLDDNRSCQDINECEHRNHTCNL 301
D+DEC+ C +C N G+Y C C G+ D SCQDINEC+ + C+
Sbjct: 5146 QDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSPCH- 5203
Query: 302 QQTCYNLQGGFKCIDPIRCEEPYLRISDNRCM 333
Q C+N G F C CE Y ++ +CM
Sbjct: 5204 -QRCFNAIGSFHC----GCEPGY-QLKGRKCM 5229
Score = 66.6 bits (161), Expect = 4e-11
Identities = 58/221 (26%), Positives = 87/221 (39%), Gaps = 47/221 (21%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI----- 69
+C + G+ + C G+ C+DI+EC +P+ C C N G + CI
Sbjct: 5288 ICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCA--HQCSNTPGSFKCICPPGQ 5345
Query: 70 ---------------------------PRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAP 102
R +PV + YS Y + + ++
Sbjct: 5346 HLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSR 5405
Query: 103 NYPTISRPLICRFGYQMDESNQ--CVDVDECA-TDSHQCNPTQICINTEGGYTCSCTDGY 159
+ +R I + + E++ CVD+DEC TD+ Q C NT G Y C C GY
Sbjct: 5406 TSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQ----HECKNTFGSYQCICPPGY 5461
Query: 160 WLLEG--QCLDIDEC--RYGYC--QQLCANVPGSYSCTCNP 194
L C DIDEC + +C ++C N+ GSY C P
Sbjct: 5462 QLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 171 bits (433), Expect = 1e-42
Identities = 95/338 (28%), Positives = 156/338 (46%), Gaps = 64/338 (18%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
LC+ PG+ QC +G+ L +C+ +D C + C + CVN +G YLC
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLC------ 344
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECAT 133
C G+ ++ + C +D CA+
Sbjct: 345 -------------------------------------QCHEGFALNPDKKTCTKIDYCAS 367
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYS 189
+H C C+NT+ Y+C C G+ L + C I+ C C+ C N+ SY
Sbjct: 368 SNHGCQ--HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 190 CTCNPGFTLNEDGRSCQDVNECA-TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C C+ G+TL+ +G++C V+ CA ++ C Q C+NT SF+C+C G+ + ED CS +
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
D C S+ C++ CVN ++ C CP G++L D ++C ++ C +H C + +C +
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
Query: 309 QGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341
+ F C +C E Y+ D + +C A + GC
Sbjct: 544 EDSFVC----QCFEGYILREDGKTCRRKDVCQAIDHGC 577
Score = 167 bits (424), Expect = 1e-41
Identities = 102/334 (30%), Positives = 153/334 (45%), Gaps = 25/334 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ QC GF L+ C ID C + C+ + CVN + Y C
Sbjct: 335 CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC-----HC 387
Query: 76 YRGPYSNP-YSTPYSGPYPAAAPPLSAPNYPTISRPLICRF--GYQMDESNQ-CVDVDEC 131
+G NP T Y A P + CR GY +D + + C VD C
Sbjct: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGY--CQQLCANVPGS 187
A H C Q+C+NTE + C C++G+ + E C +D C C+ C N+ S
Sbjct: 448 AQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRS 505
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCS 246
++C C G L DG++C ++ CA ++ C +CV++ SF+C+C GY L EDG C
Sbjct: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
D C + C+H CVN +Y C C G+ L +D + C+ + C+ +H C + C
Sbjct: 566 RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICV 623
Query: 307 NLQGGFKCIDPIRCEEPYLRISD-NRCMCPAENP 339
N + C +C E ++ D RC E P
Sbjct: 624 NNGNSYIC----KCSEGFVLAEDGRRCKKCTEGP 653
Score = 153 bits (387), Expect = 3e-37
Identities = 84/221 (38%), Positives = 110/221 (49%), Gaps = 18/221 (8%)
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPG 186
C+T H C CIN G Y C C GY L Q C D C C+QLC NVPG
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 187 SYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEEDGVHC 245
S+ C C G+ L EDG+ C V+ CA+EN C CVN GS++C+C G+ L D C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
+ +D C+ S CQHECVN +Y C C G+ L D ++C+ IN C C + C
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EHEC 417
Query: 306 YNLQGGFKCIDPIRCEEPY-LRISDNRCM----CPAENPGC 341
N++ + C RC Y L + C C ++ GC
Sbjct: 418 VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGC 454
Score = 135 bits (341), Expect = 6e-32
Identities = 65/174 (37%), Positives = 86/174 (49%), Gaps = 12/174 (6%)
Query: 177 CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPG 235
C C N+PGSY C C G+ LN D +C+ + CA E+ C Q CVN GSF+C+C G
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
Y L EDG C +D C+ C+HECVN G+Y C C G+ L D ++C I+ C
Sbjct: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGCRDQ 344
NH C Q C N + C C + + D + C PGC +
Sbjct: 369 NHGC--QHECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Score = 97.8 bits (242), Expect = 2e-20
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 211 CAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY 269
C+T E+ C C+N GS++CRC GY L D C D C+ + C+ CVN PG++
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 270 FCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISD 329
C C GY L +D + C ++ C NH C + C N G + C +C E + D
Sbjct: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPD 355
Query: 330 NRC-----MCPAENPGCRDQ 344
+ C + N GC+ +
Sbjct: 356 KKTCTKIDYCASSNHGCQHE 375
Score = 35.4 bits (80), Expect = 0.11
Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
+C+ S + +C GF L +C D C++ C + +CVN Y+C
Sbjct: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC 631
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 171 bits (433), Expect = 1e-42
Identities = 95/338 (28%), Positives = 156/338 (46%), Gaps = 64/338 (18%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
LC+ PG+ QC +G+ L +C+ +D C + C + CVN +G YLC
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLC------ 344
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECAT 133
C G+ ++ + C +D CA+
Sbjct: 345 -------------------------------------QCHEGFALNPDKKTCTKIDYCAS 367
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYS 189
+H C C+NT+ Y+C C G+ L + C I+ C C+ C N+ SY
Sbjct: 368 SNHGCQ--HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 190 CTCNPGFTLNEDGRSCQDVNECA-TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDM 248
C C+ G+TL+ +G++C V+ CA ++ C Q C+NT SF+C+C G+ + ED CS +
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
D C S+ C++ CVN ++ C CP G++L D ++C ++ C +H C + +C +
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
Query: 309 QGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341
+ F C +C E Y+ D + +C A + GC
Sbjct: 544 EDSFVC----QCFEGYILREDGKTCRRKDVCQAIDHGC 577
Score = 167 bits (424), Expect = 1e-41
Identities = 102/334 (30%), Positives = 153/334 (45%), Gaps = 25/334 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ QC GF L+ C ID C + C+ + CVN + Y C
Sbjct: 335 CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC-----HC 387
Query: 76 YRGPYSNP-YSTPYSGPYPAAAPPLSAPNYPTISRPLICRF--GYQMDESNQ-CVDVDEC 131
+G NP T Y A P + CR GY +D + + C VD C
Sbjct: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGY--CQQLCANVPGS 187
A H C Q+C+NTE + C C++G+ + E C +D C C+ C N+ S
Sbjct: 448 AQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRS 505
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCS 246
++C C G L DG++C ++ CA ++ C +CV++ SF+C+C GY L EDG C
Sbjct: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
D C + C+H CVN +Y C C G+ L +D + C+ + C+ +H C + C
Sbjct: 566 RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICV 623
Query: 307 NLQGGFKCIDPIRCEEPYLRISD-NRCMCPAENP 339
N + C +C E ++ D RC E P
Sbjct: 624 NNGNSYIC----KCSEGFVLAEDGRRCKKCTEGP 653
Score = 153 bits (387), Expect = 3e-37
Identities = 84/221 (38%), Positives = 110/221 (49%), Gaps = 18/221 (8%)
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPG 186
C+T H C CIN G Y C C GY L Q C D C C+QLC NVPG
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 187 SYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEEDGVHC 245
S+ C C G+ L EDG+ C V+ CA+EN C CVN GS++C+C G+ L D C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
+ +D C+ S CQHECVN +Y C C G+ L D ++C+ IN C C + C
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EHEC 417
Query: 306 YNLQGGFKCIDPIRCEEPY-LRISDNRCM----CPAENPGC 341
N++ + C RC Y L + C C ++ GC
Sbjct: 418 VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGC 454
Score = 135 bits (341), Expect = 6e-32
Identities = 65/174 (37%), Positives = 86/174 (49%), Gaps = 12/174 (6%)
Query: 177 CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPG 235
C C N+PGSY C C G+ LN D +C+ + CA E+ C Q CVN GSF+C+C G
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
Y L EDG C +D C+ C+HECVN G+Y C C G+ L D ++C I+ C
Sbjct: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGCRDQ 344
NH C Q C N + C C + + D + C PGC +
Sbjct: 369 NHGC--QHECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Score = 97.8 bits (242), Expect = 2e-20
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 211 CAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY 269
C+T E+ C C+N GS++CRC GY L D C D C+ + C+ CVN PG++
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 270 FCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISD 329
C C GY L +D + C ++ C NH C + C N G + C +C E + D
Sbjct: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPD 355
Query: 330 NRC-----MCPAENPGCRDQ 344
+ C + N GC+ +
Sbjct: 356 KKTCTKIDYCASSNHGCQHE 375
Score = 35.4 bits (80), Expect = 0.11
Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
+C+ S + +C GF L +C D C++ C + +CVN Y+C
Sbjct: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC 631
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 170 bits (431), Expect = 2e-42
Identities = 121/345 (35%), Positives = 158/345 (45%), Gaps = 33/345 (9%)
Query: 16 CLPSPGNAQAQ-CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
C+ SPG+ Q + C +G L R G+C D+DEC + C C N G + C P
Sbjct: 742 CVNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRC--SCAP 797
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI----SRPLICRFGYQMDESN-QCVDVD 129
YR P P P + P+ + S C GY+ C+DVD
Sbjct: 798 GYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 855
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY---GYC-QQLCAN 183
EC+ + C + IC NT+G + C C G+ CLD+DECR C Q C N
Sbjct: 856 ECSEED-LCQ-SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCEN 913
Query: 184 VPGSYSCT--CNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICR--CDPGY 236
PGSY C C+PG+ +G +C DV+EC P + Q C NT GS+ C CDPGY
Sbjct: 914 SPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 972
Query: 237 ELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
+ G C D+DEC F H C N PG++ C C GY D R C D+NECE
Sbjct: 973 QPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETL 1031
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPG 340
C C N++G F C+ P EE RC+ P + G
Sbjct: 1032 QGVCG-AALCENVEGSFLCVCPNSPEE--FDPMTGRCVPPRTSAG 1073
Score = 170 bits (430), Expect = 3e-42
Identities = 112/313 (35%), Positives = 147/313 (46%), Gaps = 24/313 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C PG+ + C GF R S D+DEC P C G C N G + C
Sbjct: 620 CKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFR 675
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDES-NQCVDVDECA 132
RGP + P PP + S +C G+Q + + ++C DVDEC
Sbjct: 676 SRGPGAPCQDVDECARSP---PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC- 731
Query: 133 TDSHQCNPTQICINTEGGYTC-SCTDGYWLLEGQCLDIDECRYGY--C--QQLCANVPGS 187
++H P Q C+N+ G + C +C G+ L G+C D+DEC G C C N GS
Sbjct: 732 -ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 790
Query: 188 YSCTCNPGFTLNEDGRS--CQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGV 243
+ C+C PG+ GR C DVNEC + C C+NT GSF C C PGY G
Sbjct: 791 FRCSCAPGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 849
Query: 244 HCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQ 302
C D+DECS E LCQ C N G++ C CPPG+ D SC D++EC R
Sbjct: 850 SCLDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 908
Query: 303 QTCYNLQGGFKCI 315
Q C N G ++C+
Sbjct: 909 QRCENSPGSYRCV 921
Score = 155 bits (392), Expect = 7e-38
Identities = 102/308 (33%), Positives = 135/308 (43%), Gaps = 59/308 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ P C +GF L Q +C+D+DECR +P C C N G + C+ P
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCV--CGPG 550
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+R +GP A +C+DVDEC
Sbjct: 551 FR-----------AGPRAA-----------------------------ECLDVDECHRVP 570
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY--GYC-QQLCANVPGSYSC 190
C+ + C NT G + C C GY C D+DEC G C + C N+PGS+ C
Sbjct: 571 PPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 629
Query: 191 TCNPGFTLNEDGRSC-QDVNECATE-NPC-VQTCVNTYGSFICRCDPGYELEEDGVHCSD 247
C GF G +C +DV+ECA E PC C NT GSF C C G+ G C D
Sbjct: 630 VCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 685
Query: 248 MDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
+DEC+ S C + C N G++ C CP G+ C+D++ECE NH Q C
Sbjct: 686 VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECV 743
Query: 307 NLQGGFKC 314
N G F+C
Sbjct: 744 NSPGSFQC 751
Score = 136 bits (343), Expect = 3e-32
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 20/258 (7%)
Query: 70 PRTNPVYRGPYSNPYSTPYSGPYPAAAP-PLSAPNYPTISRPLICRFGYQMDESNQCVDV 128
PRT P P + T P P P P P P S P G ++ ES +
Sbjct: 424 PRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWT--GPEIPESGPSSGM 481
Query: 129 DECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRY---GYCQQLCAN 183
C + C P + CI+ GYTC+C G+ L +C+D+DECR C N
Sbjct: 482 --CQRNPQVCGPGR-CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCEN 538
Query: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNEC-ATENPC-VQTCVNTYGSFICRCDPGYELEED 241
PGS+ C C PGF C DV+EC PC + C NT GSF+C C GY+
Sbjct: 539 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 598
Query: 242 GVHCSDMDECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSC-QDINECEHRNHTC 299
G C D+DEC+ S LC + C N PG++ C CP G+ +C +D++EC C
Sbjct: 599 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPC 654
Query: 300 NLQQTCYNLQGGFKCIDP 317
C N G F C P
Sbjct: 655 G-PGRCDNTAGSFHCACP 671
Score = 110 bits (275), Expect = 3e-24
Identities = 71/226 (31%), Positives = 89/226 (39%), Gaps = 49/226 (21%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C + G+ + C G CLD+DECR A G C N G Y C+ +P
Sbjct: 867 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 926
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
GY C DVDEC
Sbjct: 927 -----------------------------------------GYHAGPEGTCDDVDECQEY 945
Query: 135 SHQCNPTQICINTEGGYTC--SCTDGYWLLE-GQCLDIDECR-YGYC--QQLCANVPGSY 188
+ Q C NT G Y C +C GY G C D+DECR +C +C N+PGS+
Sbjct: 946 GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSF 1005
Query: 189 SCTCNPGFTLNEDGRSCQDVNECAT-ENPC-VQTCVNTYGSFICRC 232
C C+ G+ DGR C DVNEC T + C C N GSF+C C
Sbjct: 1006 QCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1051
Score = 100 bits (250), Expect = 2e-21
Identities = 81/288 (28%), Positives = 116/288 (40%), Gaps = 29/288 (10%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTN 73
A+C PG+ Q C G++ R C+D++EC T+ C G +C N G +LC+ +
Sbjct: 996 AVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNS 1054
Query: 74 PVYRGPYSNPYSTPYS--GPYPAAAP--------PLSAPNYPTISRPLICRFGYQMDESN 123
P P + P + G +P + P P P P RP R G
Sbjct: 1055 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1114
Query: 124 QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG----QCLDIDECRYGYCQQ 179
+C D A D+ C+ I C CT G G QC + Y Q
Sbjct: 1115 ECY-FDTAAPDA--CD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QS 1166
Query: 180 LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELE 239
LC + G + + + +L D CQ + ++ CVNT + C C GY
Sbjct: 1167 LCPHGRGYLAPSGD--LSLRRDVDECQLFRDQVCKSG---VCVNTAPGYSCYCSNGYYYH 1221
Query: 240 EDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286
+ C D DEC+ E C+ CVN G+Y C+C P +L R C
Sbjct: 1222 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1269
Score = 70.9 bits (172), Expect = 2e-12
Identities = 93/370 (25%), Positives = 122/370 (32%), Gaps = 62/370 (16%)
Query: 16 CLPSPGNAQA--QCTNGFDLDRQSGQCLDIDECRTI-PEACRGDMMCVNQNGGYLCIPRT 72
C SPG+ + C G+ + G C D+DEC+ PE C G C N G Y C P
Sbjct: 911 CENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEIC-GAQRCENTPGSYRCTPAC 968
Query: 73 NPVYRG-PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQ-MDESNQCVDVDE 130
+P Y+ P N P S +C GY+ + CVDV+E
Sbjct: 969 DPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNE 1027
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDG---YWLLEGQCLDIDECRYGYCQQLCANVPGS 187
C T C +C N EG + C C + + + G+C+ G P S
Sbjct: 1028 CETLQGVCGAA-LCENVEGSFLCVCPNSPEEFDPMTGRCVP-PRTSAGTFPGSQPQAPAS 1085
Query: 188 YSCTCNPGF-------TLNEDGRSCQDVNECATENPCVQTCVNTYGSFI----CRCD--- 233
P + G EC + C N + C C
Sbjct: 1086 PVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGE 1145
Query: 234 -----------PGYELEEDGVHCS----------------DMDECS-FSEFLCQHE-CVN 264
PG E E C D+DEC F + +C+ CVN
Sbjct: 1146 GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVN 1205
Query: 265 QPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEP- 323
Y C C GY C D +EC C C N G + C CE P
Sbjct: 1206 TAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHC----TCEPPL 1260
Query: 324 YLRISDNRCM 333
L S RC+
Sbjct: 1261 VLDGSQRRCV 1270
Score = 61.6 bits (148), Expect = 1e-09
Identities = 37/104 (35%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 149 GGYTCSCTDGYWLLEGQ-CLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
G Y S + Y LE + C +D C G C VP ++C C G+ L+ +C D
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCTNGRC----VRVPEGFTCRCFDGYRLDMTRMACVD 1507
Query: 208 VNEC----ATENPCVQT-CVNTYGSFICRCDPGYELEEDGVHCS 246
+NEC A CV C+NT GSF C C PG+ HC+
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1551
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/140 (28%), Positives = 53/140 (37%), Gaps = 24/140 (17%)
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECAT 133
P R PY + T S P P PP +++ P Y+ E+ +C +D C
Sbjct: 1427 PGTRWPYRSR-DTRRSFPEPEE-PPEGGSYAGSLAEP------YEELEAEECGILDGCTN 1478
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRYGYC------QQLCANVP 185
C+ G+TC C DGY L C+DI+EC C N
Sbjct: 1479 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1530
Query: 186 GSYSCTCNPGFTLNEDGRSC 205
GS+ C C PGF C
Sbjct: 1531 GSFRCICRPGFAPTHQPHHC 1550
Score = 50.4 bits (119), Expect = 3e-06
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 5/76 (6%)
Query: 207 DVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEF---LCQH-E 261
+ EC + C CV F CRC GY L+ + C D++EC +E LC +
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 262 CVNQPGTYFCSCPPGY 277
C+N G++ C C PG+
Sbjct: 1526 CLNTDGSFRCICRPGF 1541
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 155 CTDGYWLLEGQCLDIDECRYG-YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSC 205
C G+ + G C D+DEC G CQ CAN G Y+C C GF L+ SC
Sbjct: 277 CPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/63 (42%), Positives = 35/63 (55%), Gaps = 10/63 (15%)
Query: 99 LSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG 158
+SAP+ P C G++ + C DVDECAT +C + C NT GGYTC C DG
Sbjct: 270 VSAPDGP-------CPTGFER-VNGSCEDVDECATGG-RCQHGE-CANTRGGYTCVCPDG 319
Query: 159 YWL 161
+ L
Sbjct: 320 FLL 322
Score = 45.1 bits (105), Expect = 1e-04
Identities = 23/71 (32%), Positives = 30/71 (42%), Gaps = 2/71 (2%)
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQT 304
+ +EC + CV P + C C GY L +C DINEC+ L
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 305 CYNLQGGFKCI 315
C N G F+CI
Sbjct: 1526 CLNTDGSFRCI 1536
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 17/105 (16%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDIN 290
C G+E C D+DEC+ CQH EC N G Y C CP G++L SC +
Sbjct: 277 CPTGFERVNGS--CEDVDECATGG-RCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333
Query: 291 ECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMC 334
C F+ + C P LR I+ C C
Sbjct: 334 VISEAKGPC------------FRVLRDGGCSLPILRNITKQICCC 366
Score = 40.8 bits (94), Expect = 0.003
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 204 SCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHC 245
SC+DV+ECAT C C NT G + C C G+ L+ C
Sbjct: 287 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 39.7 bits (91), Expect = 0.006
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 10/61 (16%)
Query: 15 LCLPSPGNAQ------AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
LC GN++ C GF+ R +G C D+DEC T G+ C N GGY C
Sbjct: 259 LCSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGE--CANTRGGYTC 314
Query: 69 I 69
+
Sbjct: 315 V 315
Score = 34.7 bits (78), Expect = 0.18
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACR--GDMMCVNQNGGYLCIPR 71
C+ P +C +G+ LD C+DI+EC A + C+N +G + CI R
Sbjct: 1481 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1538
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 170 bits (431), Expect = 2e-42
Identities = 121/345 (35%), Positives = 158/345 (45%), Gaps = 33/345 (9%)
Query: 16 CLPSPGNAQAQ-CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
C+ SPG+ Q + C +G L R G+C D+DEC + C C N G + C P
Sbjct: 772 CVNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRC--SCAP 827
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI----SRPLICRFGYQMDESN-QCVDVD 129
YR P P P + P+ + S C GY+ C+DVD
Sbjct: 828 GYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 885
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY---GYC-QQLCAN 183
EC+ + C + IC NT+G + C C G+ CLD+DECR C Q C N
Sbjct: 886 ECSEED-LCQ-SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCEN 943
Query: 184 VPGSYSCT--CNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICR--CDPGY 236
PGSY C C+PG+ +G +C DV+EC P + Q C NT GS+ C CDPGY
Sbjct: 944 SPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 1002
Query: 237 ELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
+ G C D+DEC F H C N PG++ C C GY D R C D+NECE
Sbjct: 1003 QPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETL 1061
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPG 340
C C N++G F C+ P EE RC+ P + G
Sbjct: 1062 QGVCG-AALCENVEGSFLCVCPNSPEE--FDPMTGRCVPPRTSAG 1103
Score = 170 bits (430), Expect = 3e-42
Identities = 112/313 (35%), Positives = 147/313 (46%), Gaps = 24/313 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C PG+ + C GF R S D+DEC P C G C N G + C
Sbjct: 650 CKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFR 705
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDES-NQCVDVDECA 132
RGP + P PP + S +C G+Q + + ++C DVDEC
Sbjct: 706 SRGPGAPCQDVDECARSP---PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC- 761
Query: 133 TDSHQCNPTQICINTEGGYTC-SCTDGYWLLEGQCLDIDECRYGY--C--QQLCANVPGS 187
++H P Q C+N+ G + C +C G+ L G+C D+DEC G C C N GS
Sbjct: 762 -ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 820
Query: 188 YSCTCNPGFTLNEDGRS--CQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGV 243
+ C+C PG+ GR C DVNEC + C C+NT GSF C C PGY G
Sbjct: 821 FRCSCAPGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 879
Query: 244 HCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQ 302
C D+DECS E LCQ C N G++ C CPPG+ D SC D++EC R
Sbjct: 880 SCLDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 938
Query: 303 QTCYNLQGGFKCI 315
Q C N G ++C+
Sbjct: 939 QRCENSPGSYRCV 951
Score = 155 bits (392), Expect = 7e-38
Identities = 102/308 (33%), Positives = 135/308 (43%), Gaps = 59/308 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ P C +GF L Q +C+D+DECR +P C C N G + C+ P
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCV--CGPG 580
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+R +GP A +C+DVDEC
Sbjct: 581 FR-----------AGPRAA-----------------------------ECLDVDECHRVP 600
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY--GYC-QQLCANVPGSYSC 190
C+ + C NT G + C C GY C D+DEC G C + C N+PGS+ C
Sbjct: 601 PPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 659
Query: 191 TCNPGFTLNEDGRSC-QDVNECATE-NPC-VQTCVNTYGSFICRCDPGYELEEDGVHCSD 247
C GF G +C +DV+ECA E PC C NT GSF C C G+ G C D
Sbjct: 660 VCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 715
Query: 248 MDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
+DEC+ S C + C N G++ C CP G+ C+D++ECE NH Q C
Sbjct: 716 VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECV 773
Query: 307 NLQGGFKC 314
N G F+C
Sbjct: 774 NSPGSFQC 781
Score = 136 bits (343), Expect = 3e-32
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 20/258 (7%)
Query: 70 PRTNPVYRGPYSNPYSTPYSGPYPAAAP-PLSAPNYPTISRPLICRFGYQMDESNQCVDV 128
PRT P P + T P P P P P P S P G ++ ES +
Sbjct: 454 PRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWT--GPEIPESGPSSGM 511
Query: 129 DECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRY---GYCQQLCAN 183
C + C P + CI+ GYTC+C G+ L +C+D+DECR C N
Sbjct: 512 --CQRNPQVCGPGR-CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCEN 568
Query: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNEC-ATENPC-VQTCVNTYGSFICRCDPGYELEED 241
PGS+ C C PGF C DV+EC PC + C NT GSF+C C GY+
Sbjct: 569 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 628
Query: 242 GVHCSDMDECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSC-QDINECEHRNHTC 299
G C D+DEC+ S LC + C N PG++ C CP G+ +C +D++EC C
Sbjct: 629 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPC 684
Query: 300 NLQQTCYNLQGGFKCIDP 317
C N G F C P
Sbjct: 685 G-PGRCDNTAGSFHCACP 701
Score = 110 bits (275), Expect = 3e-24
Identities = 71/226 (31%), Positives = 89/226 (39%), Gaps = 49/226 (21%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C + G+ + C G CLD+DECR A G C N G Y C+ +P
Sbjct: 897 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 956
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
GY C DVDEC
Sbjct: 957 -----------------------------------------GYHAGPEGTCDDVDECQEY 975
Query: 135 SHQCNPTQICINTEGGYTC--SCTDGYWLLE-GQCLDIDECR-YGYC--QQLCANVPGSY 188
+ Q C NT G Y C +C GY G C D+DECR +C +C N+PGS+
Sbjct: 976 GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSF 1035
Query: 189 SCTCNPGFTLNEDGRSCQDVNECAT-ENPC-VQTCVNTYGSFICRC 232
C C+ G+ DGR C DVNEC T + C C N GSF+C C
Sbjct: 1036 QCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081
Score = 100 bits (250), Expect = 2e-21
Identities = 81/288 (28%), Positives = 116/288 (40%), Gaps = 29/288 (10%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTN 73
A+C PG+ Q C G++ R C+D++EC T+ C G +C N G +LC+ +
Sbjct: 1026 AVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNS 1084
Query: 74 PVYRGPYSNPYSTPYS--GPYPAAAP--------PLSAPNYPTISRPLICRFGYQMDESN 123
P P + P + G +P + P P P P RP R G
Sbjct: 1085 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1144
Query: 124 QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG----QCLDIDECRYGYCQQ 179
+C D A D+ C+ I C CT G G QC + Y Q
Sbjct: 1145 ECY-FDTAAPDA--CD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QS 1196
Query: 180 LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELE 239
LC + G + + + +L D CQ + ++ CVNT + C C GY
Sbjct: 1197 LCPHGRGYLAPSGD--LSLRRDVDECQLFRDQVCKSG---VCVNTAPGYSCYCSNGYYYH 1251
Query: 240 EDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286
+ C D DEC+ E C+ CVN G+Y C+C P +L R C
Sbjct: 1252 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1299
Score = 70.9 bits (172), Expect = 2e-12
Identities = 93/370 (25%), Positives = 122/370 (32%), Gaps = 62/370 (16%)
Query: 16 CLPSPGNAQA--QCTNGFDLDRQSGQCLDIDECRTI-PEACRGDMMCVNQNGGYLCIPRT 72
C SPG+ + C G+ + G C D+DEC+ PE C G C N G Y C P
Sbjct: 941 CENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEIC-GAQRCENTPGSYRCTPAC 998
Query: 73 NPVYRG-PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQ-MDESNQCVDVDE 130
+P Y+ P N P S +C GY+ + CVDV+E
Sbjct: 999 DPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNE 1057
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDG---YWLLEGQCLDIDECRYGYCQQLCANVPGS 187
C T C +C N EG + C C + + + G+C+ G P S
Sbjct: 1058 CETLQGVCGAA-LCENVEGSFLCVCPNSPEEFDPMTGRCVP-PRTSAGTFPGSQPQAPAS 1115
Query: 188 YSCTCNPGF-------TLNEDGRSCQDVNECATENPCVQTCVNTYGSFI----CRCD--- 233
P + G EC + C N + C C
Sbjct: 1116 PVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGE 1175
Query: 234 -----------PGYELEEDGVHCS----------------DMDECS-FSEFLCQHE-CVN 264
PG E E C D+DEC F + +C+ CVN
Sbjct: 1176 GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVN 1235
Query: 265 QPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEP- 323
Y C C GY C D +EC C C N G + C CE P
Sbjct: 1236 TAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHC----TCEPPL 1290
Query: 324 YLRISDNRCM 333
L S RC+
Sbjct: 1291 VLDGSQRRCV 1300
Score = 61.6 bits (148), Expect = 1e-09
Identities = 37/104 (35%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 149 GGYTCSCTDGYWLLEGQ-CLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
G Y S + Y LE + C +D C G C VP ++C C G+ L+ +C D
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCTNGRC----VRVPEGFTCRCFDGYRLDMTRMACVD 1537
Query: 208 VNEC----ATENPCVQT-CVNTYGSFICRCDPGYELEEDGVHCS 246
+NEC A CV C+NT GSF C C PG+ HC+
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1581
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/140 (28%), Positives = 53/140 (37%), Gaps = 24/140 (17%)
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECAT 133
P R PY + T S P P PP +++ P Y+ E+ +C +D C
Sbjct: 1457 PGTRWPYRSR-DTRRSFPEPEE-PPEGGSYAGSLAEP------YEELEAEECGILDGCTN 1508
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRYGYC------QQLCANVP 185
C+ G+TC C DGY L C+DI+EC C N
Sbjct: 1509 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1560
Query: 186 GSYSCTCNPGFTLNEDGRSC 205
GS+ C C PGF C
Sbjct: 1561 GSFRCICRPGFAPTHQPHHC 1580
Score = 50.4 bits (119), Expect = 3e-06
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 5/76 (6%)
Query: 207 DVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEF---LCQH-E 261
+ EC + C CV F CRC GY L+ + C D++EC +E LC +
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 262 CVNQPGTYFCSCPPGY 277
C+N G++ C C PG+
Sbjct: 1556 CLNTDGSFRCICRPGF 1571
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 155 CTDGYWLLEGQCLDIDECRYG-YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSC 205
C G+ + G C D+DEC G CQ CAN G Y+C C GF L+ SC
Sbjct: 307 CPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/63 (42%), Positives = 35/63 (55%), Gaps = 10/63 (15%)
Query: 99 LSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG 158
+SAP+ P C G++ + C DVDECAT +C + C NT GGYTC C DG
Sbjct: 300 VSAPDGP-------CPTGFER-VNGSCEDVDECATGG-RCQHGE-CANTRGGYTCVCPDG 349
Query: 159 YWL 161
+ L
Sbjct: 350 FLL 352
Score = 45.1 bits (105), Expect = 1e-04
Identities = 23/71 (32%), Positives = 30/71 (42%), Gaps = 2/71 (2%)
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQT 304
+ +EC + CV P + C C GY L +C DINEC+ L
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 305 CYNLQGGFKCI 315
C N G F+CI
Sbjct: 1556 CLNTDGSFRCI 1566
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 17/105 (16%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDIN 290
C G+E C D+DEC+ CQH EC N G Y C CP G++L SC +
Sbjct: 307 CPTGFERVNGS--CEDVDECATGG-RCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363
Query: 291 ECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMC 334
C F+ + C P LR I+ C C
Sbjct: 364 VISEAKGPC------------FRVLRDGGCSLPILRNITKQICCC 396
Score = 40.8 bits (94), Expect = 0.003
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 204 SCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHC 245
SC+DV+ECAT C C NT G + C C G+ L+ C
Sbjct: 317 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 39.7 bits (91), Expect = 0.006
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 10/61 (16%)
Query: 15 LCLPSPGNAQ------AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
LC GN++ C GF+ R +G C D+DEC T G+ C N GGY C
Sbjct: 289 LCSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGE--CANTRGGYTC 344
Query: 69 I 69
+
Sbjct: 345 V 345
Score = 34.7 bits (78), Expect = 0.18
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACR--GDMMCVNQNGGYLCIPR 71
C+ P +C +G+ LD C+DI+EC A + C+N +G + CI R
Sbjct: 1511 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1568
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 170 bits (431), Expect = 2e-42
Identities = 121/345 (35%), Positives = 158/345 (45%), Gaps = 33/345 (9%)
Query: 16 CLPSPGNAQAQ-CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
C+ SPG+ Q + C +G L R G+C D+DEC + C C N G + C P
Sbjct: 809 CVNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRC--SCAP 864
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI----SRPLICRFGYQMDESN-QCVDVD 129
YR P P P + P+ + S C GY+ C+DVD
Sbjct: 865 GYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 922
Query: 130 ECATDSHQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY---GYC-QQLCAN 183
EC+ + C + IC NT+G + C C G+ CLD+DECR C Q C N
Sbjct: 923 ECSEED-LCQ-SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCEN 980
Query: 184 VPGSYSCT--CNPGFTLNEDGRSCQDVNECATENPCV---QTCVNTYGSFICR--CDPGY 236
PGSY C C+PG+ +G +C DV+EC P + Q C NT GS+ C CDPGY
Sbjct: 981 SPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 1039
Query: 237 ELEEDGVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
+ G C D+DEC F H C N PG++ C C GY D R C D+NECE
Sbjct: 1040 QPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETL 1098
Query: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPG 340
C C N++G F C+ P EE RC+ P + G
Sbjct: 1099 QGVCG-AALCENVEGSFLCVCPNSPEE--FDPMTGRCVPPRTSAG 1140
Score = 170 bits (430), Expect = 3e-42
Identities = 112/313 (35%), Positives = 147/313 (46%), Gaps = 24/313 (7%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C PG+ + C GF R S D+DEC P C G C N G + C
Sbjct: 687 CKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFR 742
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI--SRPLICRFGYQMDES-NQCVDVDECA 132
RGP + P PP + S +C G+Q + + ++C DVDEC
Sbjct: 743 SRGPGAPCQDVDECARSP---PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC- 798
Query: 133 TDSHQCNPTQICINTEGGYTC-SCTDGYWLLEGQCLDIDECRYGY--C--QQLCANVPGS 187
++H P Q C+N+ G + C +C G+ L G+C D+DEC G C C N GS
Sbjct: 799 -ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 857
Query: 188 YSCTCNPGFTLNEDGRS--CQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGV 243
+ C+C PG+ GR C DVNEC + C C+NT GSF C C PGY G
Sbjct: 858 FRCSCAPGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 916
Query: 244 HCSDMDECSFSEFLCQHE-CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQ 302
C D+DECS E LCQ C N G++ C CPPG+ D SC D++EC R
Sbjct: 917 SCLDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 975
Query: 303 QTCYNLQGGFKCI 315
Q C N G ++C+
Sbjct: 976 QRCENSPGSYRCV 988
Score = 155 bits (392), Expect = 7e-38
Identities = 102/308 (33%), Positives = 135/308 (43%), Gaps = 59/308 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ P C +GF L Q +C+D+DECR +P C C N G + C+ P
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCV--CGPG 617
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
+R +GP A +C+DVDEC
Sbjct: 618 FR-----------AGPRAA-----------------------------ECLDVDECHRVP 637
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLLE--GQCLDIDECRY--GYC-QQLCANVPGSYSC 190
C+ + C NT G + C C GY C D+DEC G C + C N+PGS+ C
Sbjct: 638 PPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 696
Query: 191 TCNPGFTLNEDGRSC-QDVNECATE-NPC-VQTCVNTYGSFICRCDPGYELEEDGVHCSD 247
C GF G +C +DV+ECA E PC C NT GSF C C G+ G C D
Sbjct: 697 VCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 752
Query: 248 MDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
+DEC+ S C + C N G++ C CP G+ C+D++ECE NH Q C
Sbjct: 753 VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECV 810
Query: 307 NLQGGFKC 314
N G F+C
Sbjct: 811 NSPGSFQC 818
Score = 136 bits (343), Expect = 3e-32
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 20/258 (7%)
Query: 70 PRTNPVYRGPYSNPYSTPYSGPYPAAAP-PLSAPNYPTISRPLICRFGYQMDESNQCVDV 128
PRT P P + T P P P P P P S P G ++ ES +
Sbjct: 491 PRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWT--GPEIPESGPSSGM 548
Query: 129 DECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRY---GYCQQLCAN 183
C + C P + CI+ GYTC+C G+ L +C+D+DECR C N
Sbjct: 549 --CQRNPQVCGPGR-CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCEN 605
Query: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNEC-ATENPC-VQTCVNTYGSFICRCDPGYELEED 241
PGS+ C C PGF C DV+EC PC + C NT GSF+C C GY+
Sbjct: 606 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 665
Query: 242 GVHCSDMDECSFSEFLC-QHECVNQPGTYFCSCPPGYILLDDNRSC-QDINECEHRNHTC 299
G C D+DEC+ S LC + C N PG++ C CP G+ +C +D++EC C
Sbjct: 666 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPC 721
Query: 300 NLQQTCYNLQGGFKCIDP 317
C N G F C P
Sbjct: 722 G-PGRCDNTAGSFHCACP 738
Score = 110 bits (275), Expect = 3e-24
Identities = 71/226 (31%), Positives = 89/226 (39%), Gaps = 49/226 (21%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C + G+ + C G CLD+DECR A G C N G Y C+ +P
Sbjct: 934 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 993
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
GY C DVDEC
Sbjct: 994 -----------------------------------------GYHAGPEGTCDDVDECQEY 1012
Query: 135 SHQCNPTQICINTEGGYTC--SCTDGYWLLE-GQCLDIDECR-YGYC--QQLCANVPGSY 188
+ Q C NT G Y C +C GY G C D+DECR +C +C N+PGS+
Sbjct: 1013 GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSF 1072
Query: 189 SCTCNPGFTLNEDGRSCQDVNECAT-ENPC-VQTCVNTYGSFICRC 232
C C+ G+ DGR C DVNEC T + C C N GSF+C C
Sbjct: 1073 QCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1118
Score = 100 bits (250), Expect = 2e-21
Identities = 81/288 (28%), Positives = 116/288 (40%), Gaps = 29/288 (10%)
Query: 14 ALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTN 73
A+C PG+ Q C G++ R C+D++EC T+ C G +C N G +LC+ +
Sbjct: 1063 AVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNS 1121
Query: 74 PVYRGPYSNPYSTPYS--GPYPAAAP--------PLSAPNYPTISRPLICRFGYQMDESN 123
P P + P + G +P + P P P P RP R G
Sbjct: 1122 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1181
Query: 124 QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG----QCLDIDECRYGYCQQ 179
+C D A D+ C+ I C CT G G QC + Y Q
Sbjct: 1182 ECY-FDTAAPDA--CD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QS 1233
Query: 180 LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELE 239
LC + G + + + +L D CQ + ++ CVNT + C C GY
Sbjct: 1234 LCPHGRGYLAPSGD--LSLRRDVDECQLFRDQVCKSG---VCVNTAPGYSCYCSNGYYYH 1288
Query: 240 EDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSC 286
+ C D DEC+ E C+ CVN G+Y C+C P +L R C
Sbjct: 1289 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1336
Score = 70.9 bits (172), Expect = 2e-12
Identities = 93/370 (25%), Positives = 122/370 (32%), Gaps = 62/370 (16%)
Query: 16 CLPSPGNAQA--QCTNGFDLDRQSGQCLDIDECRTI-PEACRGDMMCVNQNGGYLCIPRT 72
C SPG+ + C G+ + G C D+DEC+ PE C G C N G Y C P
Sbjct: 978 CENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEIC-GAQRCENTPGSYRCTPAC 1035
Query: 73 NPVYRG-PYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQ-MDESNQCVDVDE 130
+P Y+ P N P S +C GY+ + CVDV+E
Sbjct: 1036 DPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNE 1094
Query: 131 CATDSHQCNPTQICINTEGGYTCSCTDG---YWLLEGQCLDIDECRYGYCQQLCANVPGS 187
C T C +C N EG + C C + + + G+C+ G P S
Sbjct: 1095 CETLQGVCGAA-LCENVEGSFLCVCPNSPEEFDPMTGRCVP-PRTSAGTFPGSQPQAPAS 1152
Query: 188 YSCTCNPGF-------TLNEDGRSCQDVNECATENPCVQTCVNTYGSFI----CRCD--- 233
P + G EC + C N + C C
Sbjct: 1153 PVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGE 1212
Query: 234 -----------PGYELEEDGVHCS----------------DMDECS-FSEFLCQHE-CVN 264
PG E E C D+DEC F + +C+ CVN
Sbjct: 1213 GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVN 1272
Query: 265 QPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEP- 323
Y C C GY C D +EC C C N G + C CE P
Sbjct: 1273 TAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHC----TCEPPL 1327
Query: 324 YLRISDNRCM 333
L S RC+
Sbjct: 1328 VLDGSQRRCV 1337
Score = 61.6 bits (148), Expect = 1e-09
Identities = 37/104 (35%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 149 GGYTCSCTDGYWLLEGQ-CLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
G Y S + Y LE + C +D C G C VP ++C C G+ L+ +C D
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCTNGRC----VRVPEGFTCRCFDGYRLDMTRMACVD 1574
Query: 208 VNEC----ATENPCVQT-CVNTYGSFICRCDPGYELEEDGVHCS 246
+NEC A CV C+NT GSF C C PG+ HC+
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1618
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/140 (28%), Positives = 53/140 (37%), Gaps = 24/140 (17%)
Query: 74 PVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECAT 133
P R PY + T S P P PP +++ P Y+ E+ +C +D C
Sbjct: 1494 PGTRWPYRSR-DTRRSFPEPEE-PPEGGSYAGSLAEP------YEELEAEECGILDGCTN 1545
Query: 134 DSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECRYGYC------QQLCANVP 185
C+ G+TC C DGY L C+DI+EC C N
Sbjct: 1546 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1597
Query: 186 GSYSCTCNPGFTLNEDGRSC 205
GS+ C C PGF C
Sbjct: 1598 GSFRCICRPGFAPTHQPHHC 1617
Score = 50.4 bits (119), Expect = 3e-06
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 5/76 (6%)
Query: 207 DVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEF---LCQH-E 261
+ EC + C CV F CRC GY L+ + C D++EC +E LC +
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 262 CVNQPGTYFCSCPPGY 277
C+N G++ C C PG+
Sbjct: 1593 CLNTDGSFRCICRPGF 1608
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 155 CTDGYWLLEGQCLDIDECRYG-YCQQ-LCANVPGSYSCTCNPGFTLNEDGRSC 205
C G+ + G C D+DEC G CQ CAN G Y+C C GF L+ SC
Sbjct: 344 CPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/63 (42%), Positives = 35/63 (55%), Gaps = 10/63 (15%)
Query: 99 LSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG 158
+SAP+ P C G++ + C DVDECAT +C + C NT GGYTC C DG
Sbjct: 337 VSAPDGP-------CPTGFER-VNGSCEDVDECATGG-RCQHGE-CANTRGGYTCVCPDG 386
Query: 159 YWL 161
+ L
Sbjct: 387 FLL 389
Score = 45.1 bits (105), Expect = 1e-04
Identities = 23/71 (32%), Positives = 30/71 (42%), Gaps = 2/71 (2%)
Query: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQT 304
+ +EC + CV P + C C GY L +C DINEC+ L
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 305 CYNLQGGFKCI 315
C N G F+CI
Sbjct: 1593 CLNTDGSFRCI 1603
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 17/105 (16%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLDDNRSCQDIN 290
C G+E C D+DEC+ CQH EC N G Y C CP G++L SC +
Sbjct: 344 CPTGFERVNGS--CEDVDECATGG-RCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400
Query: 291 ECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR-ISDNRCMC 334
C F+ + C P LR I+ C C
Sbjct: 401 VISEAKGPC------------FRVLRDGGCSLPILRNITKQICCC 433
Score = 40.8 bits (94), Expect = 0.003
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 204 SCQDVNECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHC 245
SC+DV+ECAT C C NT G + C C G+ L+ C
Sbjct: 354 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 39.7 bits (91), Expect = 0.006
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 10/61 (16%)
Query: 15 LCLPSPGNAQ------AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
LC GN++ C GF+ R +G C D+DEC T G+ C N GGY C
Sbjct: 326 LCSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGE--CANTRGGYTC 381
Query: 69 I 69
+
Sbjct: 382 V 382
Score = 34.7 bits (78), Expect = 0.18
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACR--GDMMCVNQNGGYLCIPR 71
C+ P +C +G+ LD C+DI+EC A + C+N +G + CI R
Sbjct: 1548 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1605
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 166 bits (421), Expect = 3e-41
Identities = 103/310 (33%), Positives = 142/310 (45%), Gaps = 15/310 (4%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C G+ + C G+++ C D+DEC + G +C+N G + C N
Sbjct: 1025 CTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTG--LCLNTEGSFACSACENGY 1082
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDE-SNQCVDVDECATD 134
+ +P P N C GY+ + C DVDEC
Sbjct: 1083 WVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDP 1142
Query: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ-CLDIDECR-YGYC--QQLCANVPGSYSC 190
C + C NT G Y C C G+ L G C D++EC +C C N GS+ C
Sbjct: 1143 QSSCLGGE-CKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFC 1201
Query: 191 TCNPGFTLNEDGRSCQDVNECATENPCV-QTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
C PGF E G SCQDV+ECAT +PCV CVNT GSF C C+ G++ + C D+D
Sbjct: 1202 LCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDID 1261
Query: 250 EC-SFSEFLC-QHECVNQPGTYFC--SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
EC + + +C +C N PG+Y C C PG+ + N C DI+EC + + C C
Sbjct: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA-PNGDCIDIDECAN-DTMCGSHGFC 1319
Query: 306 YNLQGGFKCI 315
N G F+C+
Sbjct: 1320 DNTDGSFRCL 1329
Score = 164 bits (415), Expect = 2e-40
Identities = 115/372 (30%), Positives = 161/372 (43%), Gaps = 68/372 (18%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ +C G+ + R+ G C DI+ECR P C D CVN G Y C+
Sbjct: 945 CTNTEGSYHCECDQGYIMVRK-GHCQDINECRH-PGTCP-DGRCVNSPGSYTCLA-CEEG 1000
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTI---SRPLICRFGYQMDESNQ-CVDVDEC 131
YRG + P + A T S C GY++ + C DVDEC
Sbjct: 1001 YRGQSGSCVDVN-----ECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
Query: 132 ATDSHQCNPTQICINTEGGYTCS-CTDGYWLLEG--QCLDIDECRY-------------- 174
A S PT +C+NTEG + CS C +GYW+ E C D+DEC +
Sbjct: 1056 A--SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAG 1113
Query: 175 ---------GY--------CQQL--------------CANVPGSYSCTCNPGFTLNEDGR 203
GY C+ + C N GSY C C GF L +G
Sbjct: 1114 SFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGT 1172
Query: 204 SCQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHE 261
C+DVNEC E C C+N++GSF C C PG+ E G C D+DEC+ ++
Sbjct: 1173 VCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH 1232
Query: 262 CVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCE 321
CVN G++ C C G+ ++ C DI+ECE C N G ++C+ + C+
Sbjct: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV--LGCQ 1290
Query: 322 EPYLRISDNRCM 333
+ + C+
Sbjct: 1291 PGFHMAPNGDCI 1302
Score = 147 bits (370), Expect = 2e-35
Identities = 101/324 (31%), Positives = 139/324 (42%), Gaps = 54/324 (16%)
Query: 43 IDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYST--------PYSGP--- 91
ID C G CVN GY C+ +P Y+ S Y T P G
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCV--CSPGYQLHPSQAYCTDDNECLRDPCKGKGRC 902
Query: 92 -----------YP-----AAAPPLSAPNYPTISRPLICR----------------FGYQM 119
YP + + +P +C GY M
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
Query: 120 DESNQCVDVDECATDSHQCNPTQICINTEGGYTC-SCTDGYWLLEGQCLDIDEC-RYGYC 177
C D++EC C P C+N+ G YTC +C +GY G C+D++EC G C
Sbjct: 963 VRKGHCQDINECRHPG-TC-PDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVC 1020
Query: 178 QQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPC-VQTCVNTYGSFIC-RCDP 234
C N+ GS+ C+C G+ + D + CQDV+ECA+ C C+NT GSF C C+
Sbjct: 1021 AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACEN 1080
Query: 235 GYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFC-SCPPGYILLDDNRSCQDINECE 293
GY + EDG C D+DEC+F C N G++ C C GY SC+D++ECE
Sbjct: 1081 GYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE 1140
Query: 294 HRNHTCNLQQTCYNLQGGFKCIDP 317
+C L C N G ++C+ P
Sbjct: 1141 DPQSSC-LGGECKNTVGSYQCLCP 1163
Score = 137 bits (345), Expect = 2e-32
Identities = 85/224 (37%), Positives = 107/224 (47%), Gaps = 25/224 (11%)
Query: 128 VDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGYC--QQLCAN 183
+D CA + C+N GY C C+ GY L Q C D +EC C + C N
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
Query: 184 VPGSYSCTCNPGFTLNEDG--RSCQDVNECATENPCV-QTCVNTYGSFICRCDPGYELEE 240
GSYSC C PG+TL G + CQD+NEC C C NT GS+ C CD GY +
Sbjct: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
Query: 241 DGVHCSDMDECSFSEFLCQHECVNQPGTYFC-SCPPGYILLDDNRSCQDINECEHRNHTC 299
G HC D++EC CVN PG+Y C +C GY + SC D+NEC C
Sbjct: 965 KG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLTPG-VC 1020
Query: 300 NLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRD 343
C NL+G F+C CE+ Y SD + GC+D
Sbjct: 1021 -AHGKCTNLEGSFRC----SCEQGYEVTSDEK--------GCQD 1051
Score = 134 bits (338), Expect = 1e-31
Identities = 83/223 (37%), Positives = 110/223 (49%), Gaps = 21/223 (9%)
Query: 112 ICRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG----QC 166
+C GYQ+ S C D +EC D C CIN G Y+C C GY L +C
Sbjct: 871 VCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLATSGATQEC 928
Query: 167 LDIDECRY-GYCQQ-LCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ-TCVN 223
DI+EC G C C N GSY C C+ G+ + G CQD+NEC C CVN
Sbjct: 929 QDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQDINECRHPGTCPDGRCVN 987
Query: 224 TYGSFIC-RCDPGYELEEDGVHCSDMDECSFSEFLCQH-ECVNQPGTYFCSCPPGYILLD 281
+ GS+ C C+ GY + C D++EC + +C H +C N G++ CSC GY +
Sbjct: 988 SPGSYTCLACEEGYRGQSGS--CVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTS 1044
Query: 282 DNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPY 324
D + CQD++EC R +C C N +G F C CE Y
Sbjct: 1045 DEKGCQDVDECASR-ASCP-TGLCLNTEGSFAC---SACENGY 1082
Score = 124 bits (312), Expect = 1e-28
Identities = 92/273 (33%), Positives = 124/273 (45%), Gaps = 21/273 (7%)
Query: 15 LCLPSPGNAQAQ-CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI-PRT 72
+C + G+ + C G+ C D+DEC +C G C N G Y C+ P+
Sbjct: 1107 VCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTVGSYQCLCPQG 1165
Query: 73 NPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESN-QCVDVDEC 131
+ G + + AP N S +C G+ E C DVDEC
Sbjct: 1166 FQLANGTVCEDVNECMGEEH--CAPHGECLNSHG-SFFCLCAPGFVSAEGGTSCQDVDEC 1222
Query: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLL--EGQCLDIDECR-YG--YCQQL-CANVP 185
AT + C C+NTEG + C C G+ G+C+DIDEC YG C C N P
Sbjct: 1223 AT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSP 1280
Query: 186 GSYSCT--CNPGFTLNEDGRSCQDVNECATENPCVQT--CVNTYGSFICRCDPGYELEED 241
GSY C C PGF + +G C D++ECA + C C NT GSF C CD G+E+
Sbjct: 1281 GSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPS 1339
Query: 242 GVHCSDMDECSFSEFLCQHE-CVNQPGTYFCSC 273
G C D++EC +C C N G++ C C
Sbjct: 1340 GWDCVDVNECELMLAVCGAALCENVEGSFLCLC 1372
Score = 90.5 bits (223), Expect = 3e-18
Identities = 87/387 (22%), Positives = 129/387 (33%), Gaps = 76/387 (19%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ + G+ C GF +SG+C+DIDEC + G C N G Y C+ P
Sbjct: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
Query: 76 YR-GPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESN-QCVDVDECAT 133
+ P + N R L C G+++ S CVDV+EC
Sbjct: 1293 FHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCL-CDQGFEISPSGWDCVDVNECEL 1351
Query: 134 DSHQCNPTQICINTEGGYTCSCT---DGYWLLEGQC------------------------ 166
C +C N EG + C C + Y EG C
Sbjct: 1352 MLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTR 1410
Query: 167 LDIDECRYGY--CQQLCANVPGSYSCTCNPGFTLNEDGRSCQ------------------ 206
+D + G+ C + C C G + + C
Sbjct: 1411 MDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYI 1470
Query: 207 --------------DVNECATENPCV---QTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
D +EC P + C+NT ++C C+PG+ + C D D
Sbjct: 1471 PVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHD 1530
Query: 250 ECSFSEFLCQH-ECVNQPGTYFCSC-PPGYILLDDNRSCQDINECEHRNHTCNLQQTCYN 307
EC + C++ ECVN G++ C C PP + L R + E C+
Sbjct: 1531 EC--QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWK 1588
Query: 308 LQGGFKCIDPIRCEEPYLRISDNRCMC 334
C +P+R R + C C
Sbjct: 1589 KVTNDVCSEPLRGH----RTTYTECCC 1611
Score = 82.4 bits (202), Expect = 8e-16
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 11/134 (8%)
Query: 204 SCQDVNECAT--ENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQH 260
S ++ CA N C TCVN + C C PGY+L +C+D +EC +
Sbjct: 841 STPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900
Query: 261 ECVNQPGTYFCSCPPGYILLDD--NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPI 318
C+N+ G+Y C C PGY L + CQDINECE C+ Q C N +G + C
Sbjct: 901 RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPG-VCSGGQ-CTNTEGSYHC---- 954
Query: 319 RCEEPYLRISDNRC 332
C++ Y+ + C
Sbjct: 955 ECDQGYIMVRKGHC 968
Score = 58.2 bits (139), Expect = 2e-08
Identities = 33/87 (37%), Positives = 41/87 (47%), Gaps = 9/87 (10%)
Query: 165 QCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP----CVQ- 219
+C ++ C G C V Y+C C GF L+ +C DVNEC N CV
Sbjct: 1736 ECGILNGCENGRC----VRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG 1791
Query: 220 TCVNTYGSFICRCDPGYELEEDGVHCS 246
C NT GS+ C C PGY E HC+
Sbjct: 1792 YCENTEGSYRCHCSPGYVAEAGPPHCT 1818
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/103 (33%), Positives = 45/103 (43%), Gaps = 12/103 (11%)
Query: 232 CDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
C GY+ + HC D++EC ECVN G+Y C+C PG ++LD +RS
Sbjct: 608 CPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG-LMLDPSRS-----R 660
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMC 334
C LQ CY G C P+ RI+ C C
Sbjct: 661 CVSDKAISMLQGLCYRSLGPGTCTLPLA-----QRITKQICCC 698
Score = 50.1 bits (118), Expect = 4e-06
Identities = 28/71 (39%), Positives = 34/71 (47%), Gaps = 5/71 (7%)
Query: 205 CQDVNECATENPCVQT-CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECV 263
CQD+NEC T C CVNT GS++C C PG L+ C S + LC
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSL- 678
Query: 264 NQPGTYFCSCP 274
PGT C+ P
Sbjct: 679 -GPGT--CTLP 686
Score = 50.1 bits (118), Expect = 4e-06
Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 210 ECATENPCVQ-TCVNTYGSFICRCDPGYELEEDGVHCSDMDEC---SFSEFLCQH-ECVN 264
EC N C CV + C C G++L+ + C D++EC + LC H C N
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
Query: 265 QPGTYFCSCPPGYI 278
G+Y C C PGY+
Sbjct: 1796 TEGSYRCHCSPGYV 1809
Score = 49.7 bits (117), Expect = 5e-06
Identities = 40/155 (25%), Positives = 60/155 (38%), Gaps = 27/155 (17%)
Query: 70 PRTNPVYRGPYSNPYSTPYSGPYPAAA-------PPLSAPNYPTISRPLICRFGYQMDES 122
P P Y Y P T +P A P L +P P+ +P +
Sbjct: 1671 PDGAPFYN--YLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAG 1728
Query: 123 NQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL--LEGQCLDIDECR------- 173
+ + +EC + C + C+ GYTC C +G+ L C+D++EC
Sbjct: 1729 FEGLQAEECGI-LNGCENGR-CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAV 1786
Query: 174 ---YGYCQQLCANVPGSYSCTCNPGFTLNEDGRSC 205
+GYC+ N GSY C C+PG+ C
Sbjct: 1787 LCVHGYCE----NTEGSYRCHCSPGYVAEAGPPHC 1817
Score = 45.4 bits (106), Expect = 1e-04
Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 8/99 (8%)
Query: 99 LSAPNYPTISRPLI------CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYT 152
L AP P + P+I C GY+ C D++EC T C + C+NT G Y
Sbjct: 588 LCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLG-LCKDAE-CVNTRGSYL 645
Query: 153 CSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCT 191
C+C G L + + + Q LC G +CT
Sbjct: 646 CTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCT 684
Score = 42.4 bits (98), Expect = 9e-04
Identities = 23/54 (42%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 155 CTDGYWLLE-GQCLDIDEC-RYGYCQQL-CANVPGSYSCTCNPGFTLNEDGRSC 205
C GY L C DI+EC G C+ C N GSY CTC PG L+ C
Sbjct: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 40.0 bits (92), Expect = 0.004
Identities = 26/67 (38%), Positives = 33/67 (49%), Gaps = 8/67 (11%)
Query: 10 VTILALCLPSPG-----NAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNG 64
VT+ A C P P N Q +C G+ + C DI+EC T+ C+ D CVN G
Sbjct: 586 VTLCAPCPPRPASPVIENGQLECPQGYKRLNLT-HCQDINECLTLG-LCK-DAECVNTRG 642
Query: 65 GYLCIPR 71
YLC R
Sbjct: 643 SYLCTCR 649
Score = 37.7 bits (86), Expect = 0.021
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNL--QQTCY 306
+EC CV Y C C G+ L + +C D+NEC+ N L C
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
Query: 307 NLQGGFKC 314
N +G ++C
Sbjct: 1795 NTEGSYRC 1802
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/62 (30%), Positives = 25/62 (40%), Gaps = 4/62 (6%)
Query: 27 CTNGFDLDRQSGQCLDIDECRTI--PEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPY 84
C GF LD C+D++EC + P C N G Y C +P Y P+
Sbjct: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRC--HCSPGYVAEAGPPH 1816
Query: 85 ST 86
T
Sbjct: 1817 CT 1818
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 158 bits (399), Expect = 1e-38
Identities = 92/294 (31%), Positives = 130/294 (44%), Gaps = 31/294 (10%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C+ +PG+ +C GF L S CL I+ C C+ + C+ T
Sbjct: 176 CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQ-----------HHCVQLTITR 224
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLI--------CRFGYQMD-ESNQCV 126
+R + G + P + N + R + C GYQ+ + C
Sbjct: 225 HRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE 284
Query: 127 DVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL---------LEGQCLDIDECRYGYC 177
DVDECA QC C+NT+G + C C GY L +E + ++ E G C
Sbjct: 285 DVDECAAGLAQC--AHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGC 342
Query: 178 QQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYE 237
C++ CTC G+ L+ D R+C DV++CA C Q C N G + C C GY
Sbjct: 343 SHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYR 402
Query: 238 LEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINE 291
L DG C D+DEC+ S C+H C N G++ CSC GY L +D R C + E
Sbjct: 403 LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 456
Score = 157 bits (398), Expect = 1e-38
Identities = 116/334 (34%), Positives = 146/334 (43%), Gaps = 31/334 (9%)
Query: 20 PGNAQ-AQCTNGFDLDRQSGQC-LDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYR 77
PG+AQ C GF Q +C D+DECRT C+ CVN G YLC P +R
Sbjct: 141 PGSAQPCHCPPGF----QGPRCQYDVDECRTHNGGCQH--RCVNTPGSYLC--ECKPGFR 192
Query: 78 GPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLI-CRFGYQMDESNQ-CVDVDECATDS 135
+ + TI+R CR G+Q+ E + CV CA +
Sbjct: 193 LHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRN 252
Query: 136 HQCNPTQICINTEGGYTCSCTDGYWLL-EGQ-CLDIDECRYGY--CQQLCANVPGSYSCT 191
C C G C C GY L +G+ C D+DEC G C C N GS+ C
Sbjct: 253 GSC--MHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCV 310
Query: 192 CNPGFTLNEDGRSC-----QDVNECATENP-CVQTCVNTYGSFICRCDPGYELEEDGVHC 245
C+ G+ L DGR C + VN C N C C +T +C C GYEL+ D C
Sbjct: 311 CHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTC 370
Query: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
D+D+C+ S CQ C N PG Y C C GY L D C+D++EC C + C
Sbjct: 371 IDVDDCADSP-CCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC--EHHC 427
Query: 306 YNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENP 339
NL G F+C CE Y D R P E P
Sbjct: 428 TNLAGSFQC----SCEAGYRLHEDRRGCSPLEEP 457
Score = 135 bits (340), Expect = 7e-32
Identities = 89/254 (35%), Positives = 113/254 (44%), Gaps = 27/254 (10%)
Query: 104 YPTISRPLI--CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWL 161
Y T +R ++ CR Q + C+ EC+ C C+ C C G+
Sbjct: 100 YTTEARTVLRCCRGWMQQPDEEGCLSA-ECSASL--CFHGGRCV-PGSAQPCHCPPGFQG 155
Query: 162 LEGQCLDIDECRY--GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CV 218
Q D+DECR G CQ C N PGSY C C PGF L+ D R+C +N CA N C
Sbjct: 156 PRCQ-YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQ 214
Query: 219 QTCVN-TYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGY 277
CV T C+C PG++L+EDG HC C+ C H C G C C GY
Sbjct: 215 HHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGY 274
Query: 278 ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR-C---- 332
L D ++C+D++EC C C N QG FKC+ C Y +D R C
Sbjct: 275 QLAADGKACEDVDECAAGLAQC--AHGCLNTQGSFKCV----CHAGYELGADGRQCYRIE 328
Query: 333 -----MCPAENPGC 341
C A N GC
Sbjct: 329 MEIVNSCEANNGGC 342
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/317 (24%), Positives = 112/317 (35%), Gaps = 60/317 (18%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
+C +PG + C G+ L C D+DEC + C + C N G + C
Sbjct: 385 VCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC--EHHCTNLAGSFQCSCEAG- 441
Query: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
YR G P P + RPL DE Q D+ D
Sbjct: 442 -YR------LHEDRRGCSPLEEPMVDLDGELPFVRPL-PHIAVLQDELPQLFQDDDVGAD 493
Query: 135 --------SHQCNPTQICINTEGGYTCSCTDGYWLLEGQC---LDIDECRYGYCQQLCAN 183
H +C++ G+ CS T G C LD +C G+ +C
Sbjct: 494 EEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNE 553
Query: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELE--ED 241
TC P + G++C C+ +N TC + G+ CRC PG ED
Sbjct: 554 -------TCPP----DTFGKNCS--FSCSCQNG--GTCDSVTGA--CRCPPGVSGTNCED 596
Query: 242 GV-------HCSDMDECSFSEFLCQH---ECVNQPGTY--FC--SCPPGYILLDDNRSCQ 287
G HC C+ + C C+ PG Y FC +CPP + CQ
Sbjct: 597 GCPKGYYGKHCRKKCNCA-NRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQ 655
Query: 288 DI----NECEHRNHTCN 300
+ C+ R+ +C+
Sbjct: 656 CVQPHTQSCDKRDGSCS 672
Score = 52.4 bits (124), Expect = 8e-07
Identities = 95/400 (23%), Positives = 125/400 (31%), Gaps = 127/400 (31%)
Query: 27 CTNGFDLDRQSGQCLDID---------EC--RTIPEACRGDMMCVNQNGGYLCIPRT--- 72
C NG D SG C + EC R + CR C+N G LC P T
Sbjct: 1048 CQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLN---GGLCDPHTGRC 1104
Query: 73 ------------NPVYRGPYSNPYSTPYSGPYPAAAPPLSA-----PNYPTISRPLICRF 115
+P RG + + S P AA ++ P + C
Sbjct: 1105 LCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPP 1164
Query: 116 GYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC--- 172
G C + +C ++ C+P TCSC GY Q C
Sbjct: 1165 G---SFGEDCAQMCQCPGENPACHPAT--------GTCSCAAGYHGPSCQ----QRCPPG 1209
Query: 173 RYGY-CQQLCANVPGSY------SCTCNPGFTLNED----------GRSCQDVNEC---A 212
RYG C+QLC + G +C C GF L D G +C V C A
Sbjct: 1210 RYGPGCEQLCGCLNGGSCDAATGACRCPTGF-LGTDCNLTCPQGRFGPNCTHVCGCGQGA 1268
Query: 213 TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFS------------------ 254
+P TC+ G RC+ G GV C C
Sbjct: 1269 ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTG 1328
Query: 255 ------------------EFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRN 296
E C + +P T C C PG+ ++C+ + C
Sbjct: 1329 RHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFY----GQACE--HPCPPGF 1382
Query: 297 HTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPA 336
H Q C+ Q G C DPI RC+CPA
Sbjct: 1383 HGAGCQGLCW-CQHGAPC-DPI----------SGRCLCPA 1410
Score = 49.3 bits (116), Expect = 7e-06
Identities = 48/185 (25%), Positives = 61/185 (32%), Gaps = 44/185 (23%)
Query: 177 CQQLCANVPGSY------SCTCNPGFTLN---------EDGRSCQDVNECATENPCVQTC 221
C Q C+ PG+ +C C PGFT + G C + +C ENP
Sbjct: 1128 CAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPA 1187
Query: 222 VNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVN----QPGTYFCSCPPGY 277
T C C GY C E LC C+N T C CP G+
Sbjct: 1188 TGT-----CSCAAGYHGPSCQQRCPPGRYGPGCEQLCG--CLNGGSCDAATGACRCPTGF 1240
Query: 278 ILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAE 337
+ D N +C + H C Q G C DP+ C+CP
Sbjct: 1241 LGTDCNLTCPQGRFGPNCTHVCGCGQ-------GAAC-DPV----------TGTCLCPPG 1282
Query: 338 NPGCR 342
G R
Sbjct: 1283 RAGVR 1287
Score = 44.7 bits (104), Expect = 2e-04
Identities = 84/366 (22%), Positives = 121/366 (33%), Gaps = 88/366 (24%)
Query: 46 CRTIPEACRGDMMCVNQNGGYLCIP-----RTNPVYRGPYSNP-----YSTPYSGP-YPA 94
C+ I AC+ C + G LC+P R V + P S G +PA
Sbjct: 782 CQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPA 841
Query: 95 AAPPLSAPNYPTISRPLICRFG-YQMDESNQCVDVDECATDSHQCNPTQICINTEGGYT- 152
AP + S C G + D S+ C C+ C+ E GY
Sbjct: 842 TGHCSCAPGWTGFSCQRACDTGHWGPDCSHPC----NCSAGHGSCDAISGLCLCEAGYVG 897
Query: 153 -------------------CSCTDGYWL--LEGQCLDIDECRYGYCQQLCA----NVPGS 187
C C G + G C R +C+ C +
Sbjct: 898 PRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCR 957
Query: 188 YSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTC-VNTYG---SFICRCDPGYELE--E 240
+C C G + SC + P C +TC +TYG S C C G +
Sbjct: 958 SACNCTAGAACDAVNGSC--LCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVH 1015
Query: 241 DGVHC-------SDMDECSFSEF--LCQHECVNQ------PGTYFCSCPPGYILLDDNRS 285
HC S + C + C+H C+ Q P + C+CP G+ L +
Sbjct: 1016 GQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGL----A 1071
Query: 286 CQDINECEHRNHTCNLQQTCYNLQGGF------KCIDPI-----RCEEPYLR-----ISD 329
C+ EC R+ + + L GG +C+ P +C+ P LR
Sbjct: 1072 CE--KECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACA 1129
Query: 330 NRCMCP 335
RC CP
Sbjct: 1130 QRCSCP 1135
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/257 (25%), Positives = 86/257 (33%), Gaps = 83/257 (32%)
Query: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQC------ 166
C G+Q ++ Q EC + N + C + GG C + GQC
Sbjct: 718 CPAGFQGEDCGQ-----ECPVGTFGVNCSSSC--SCGGAPCHG------VTGQCRCPPGR 764
Query: 167 ------LDIDECRYGY-CQQLCANV-------PGSYSCTCNPGFTLNEDGRSCQDVNECA 212
D E R+G CQ++C P + +C C PGF G CQDV
Sbjct: 765 TGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFV----GSRCQDVCPAG 820
Query: 213 TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCS 272
P QT C C DG HC P T CS
Sbjct: 821 WYGPSCQTR--------CSC------ANDG-HC-------------------HPATGHCS 846
Query: 273 CPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPI-RCEEPYLRISDNR 331
C PG+ R+C + +H CN C G I + CE Y+ R
Sbjct: 847 CAPGWTGFSCQRACDTGHWGPDCSHPCN----CSAGHGSCDAISGLCLCEAGYV---GPR 899
Query: 332 C--MCPAEN--PGCRDQ 344
C CP + PGC +
Sbjct: 900 CEQQCPQGHFGPGCEQR 916
Score = 39.3 bits (90), Expect = 0.007
Identities = 56/238 (23%), Positives = 81/238 (34%), Gaps = 62/238 (26%)
Query: 153 CSCTDGYWL--LEGQCLDIDECRYGYCQQLC-ANVPG---SYSCTCNPGFTLNEDGRSCQ 206
C+CT G + G CL R C + C A+ G S +C C +G SC
Sbjct: 960 CNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACF-------NGASCD 1012
Query: 207 DVN---ECATE---NPCVQTC-VNTYGS---FICRCDPGYELEEDGVHCSDMDECSFSEF 256
V+ CA C+Q C YG C C G + HC+ + ++
Sbjct: 1013 PVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPE--GWAGL 1070
Query: 257 LCQHECVNQ-------------------PGTYFCSCPPGYILLDDNRSCQD------INE 291
C+ EC+ + P T C CP G+ CQ E
Sbjct: 1071 ACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWT----GDKCQSPCLRGWFGE 1126
Query: 292 CEHRNHTCNLQQTCYNLQGGFKCIDPIR---CEEP-----YLRISDNRCMCPAENPGC 341
+ +C C+++ G +C CE+ + C CP ENP C
Sbjct: 1127 ACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPAC 1184
Score = 39.3 bits (90), Expect = 0.007
Identities = 83/358 (23%), Positives = 109/358 (30%), Gaps = 72/358 (20%)
Query: 12 ILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACR---GDMMCVNQNGGYLC 68
+ C PG + C C + +C AC G C G C
Sbjct: 1143 VTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSC 1202
Query: 69 IPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLIC-------RFGYQMDE 121
R P GP +G AA A PT C RFG
Sbjct: 1203 QQRCPPGRYGPGCEQLCGCLNGGSCDAAT--GACRCPTGFLGTDCNLTCPQGRFGPNCTH 1260
Query: 122 SNQCVDVDEC--ATDSHQCNPTQICINTEGG-----------YTCSCTDG--YWLLEGQC 166
C C T + C P + + E G +TCSC +G G C
Sbjct: 1261 VCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSC 1320
Query: 167 LDIDECRYGYCQQLC--ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNT 224
C G+ + C A PG Y C+ EC+ N TC
Sbjct: 1321 ----SCGLGWTGRHCELACPPGRYGAACHL---------------ECSCHNN--STCEPA 1359
Query: 225 YGSFICRCDPGYELEEDGVHCSDMDECSFSEFLC--QHECVNQPGTYFCSCPPGYILLDD 282
G+ CRC PG+ + C + + LC QH P + C CP G+
Sbjct: 1360 TGT--CRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGF----H 1413
Query: 283 NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPG 340
C+ CE + Q C + GG C DP+ C+CP G
Sbjct: 1414 GHFCE--RGCEPGSFGEGCHQRC-DCDGGAPC-DPV----------TGLCLCPPGRSG 1457
Score = 33.9 bits (76), Expect = 0.31
Identities = 54/210 (25%), Positives = 66/210 (31%), Gaps = 39/210 (18%)
Query: 138 CNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL---CAN----VPGSYSC 190
C +C + G +CSC G W L RYG L C N P + +C
Sbjct: 1307 CRNGGLCHASNG--SCSCGLG-WTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTC 1363
Query: 191 TCNPGFTLNE---------DGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELE-- 239
C PGF G CQ + C PC S C C G+
Sbjct: 1364 RCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPI------SGRCLCPAGFHGHFC 1417
Query: 240 EDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTC 299
E G E C P T C CPPG N C+ +C
Sbjct: 1418 ERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRR----GQFGPSC 1473
Query: 300 NLQQTCYNLQGGFKCIDPI----RCEEPYL 325
L C GG C DP+ C + Y+
Sbjct: 1474 TLHCDC---GGGADC-DPVSGQCHCVDGYM 1499
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 157 bits (396), Expect = 2e-38
Identities = 116/374 (31%), Positives = 155/374 (41%), Gaps = 57/374 (15%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGY--------- 66
C+ PGN + C +GF L CLD+DEC+ C+ +CVN G Y
Sbjct: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSYECQCHSGFF 148
Query: 67 ------LCIPRTNPVYR------GPYSNPYSTPYSGPYPAAAPPLS-APNYPTISRPLIC 113
CI R+N G TP G P A N + L C
Sbjct: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT--LTC 206
Query: 114 RFGYQMDESNQCVDVDE----------------------CATDSHQCNPTQICINTEGGY 151
+G + + C D D CA ++ C+ T C +T G
Sbjct: 207 NYGNGGCQ-HSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRT--CKDTATGV 263
Query: 152 TCSCTDGYWLL-EGQ-CLDIDEC--RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
CSC G+ L +G+ C DI+EC G C C N GS+ C C G+ L D R+CQD
Sbjct: 264 RCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
Query: 208 VNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPG 267
++EC+ E C C+N+ GSF C C GY L HC D+DECS S C CVN G
Sbjct: 324 IDECSFERTCDHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQGCVNTKG 382
Query: 268 TYFCSCPPGYILLDDNRSCQDINECEHRNHTC-NLQQTCYNLQGGFKCIDPIRCEEPYLR 326
+Y C CPPG L + + C + +C R T Q +C G C ++
Sbjct: 383 SYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVP 442
Query: 327 ISDNRCMCPAENPG 340
S+N + PG
Sbjct: 443 DSENSYVLSCGVPG 456
Score = 145 bits (366), Expect = 7e-35
Identities = 101/356 (28%), Positives = 145/356 (40%), Gaps = 69/356 (19%)
Query: 41 LDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPY-SGPYPAAAPPL 99
+D+DEC + C D +C N Y C+ + P Y+G Y
Sbjct: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCK--PGYKGEGKQCEDIDECENDYYNGGCVH 89
Query: 100 SAPNYPTISRPLICRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG 158
N P R C G+ + + + C+DVDEC ++ C QIC+N G Y C C G
Sbjct: 90 ECINIPGNYR-CTCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSYECQCHSG 146
Query: 159 YWLLEGQ------------CLDID-----------------ECRYGY------------- 176
++L + Q C++ D +CR G+
Sbjct: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTC 206
Query: 177 ------CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFI 229
CQ C + +C C+ + L+ DGR+C + CA N C +TC +T
Sbjct: 207 NYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVR 264
Query: 230 CRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDI 289
C C G+ L+ DG C D++EC + C H C N G++ C C GY LL D R+CQDI
Sbjct: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDI 324
Query: 290 NECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC----MCPAENPGC 341
+EC TC+ C N G F+C+ C Y+ C C N C
Sbjct: 325 DECSF-ERTCD--HICINSPGSFQCL----CHRGYILYGTTHCGDVDECSMSNGSC 373
Score = 56.6 bits (135), Expect = 4e-08
Identities = 50/210 (23%), Positives = 73/210 (34%), Gaps = 58/210 (27%)
Query: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
C + G+ + C G+ L C DIDEC + C D +C+N G + C+
Sbjct: 297 CRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTC--DHICINSPGSFQCL------ 347
Query: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
C GY + + C DVDEC+ +
Sbjct: 348 -------------------------------------CHRGYILYGTTHCGDVDECSMSN 370
Query: 136 HQCNPTQICINTEGGYTCSCTDG---YWLLEGQCLDIDEC-----RYGYCQQLCANVPGS 187
C+ Q C+NT+G Y C C G +W + C++ +C Q C+ G
Sbjct: 371 GSCD--QGCVNTKGSYECVCPPGRRLHWNGK-DCVETGKCLSRAKTSPRAQLSCSKAGGV 427
Query: 188 YSCTCN-PGFTLNEDGRSCQDVNECATENP 216
SC + P TL V C P
Sbjct: 428 ESCFLSCPAHTLFVPDSENSYVLSCGVPGP 457
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI 69
+C+ SPG+ Q C G+ L + C D+DEC +C D CVN G Y C+
Sbjct: 336 ICINSPGSFQCLCHRGYIL-YGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECV 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.468
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,744,188
Number of Sequences: 37866
Number of extensions: 1209910
Number of successful extensions: 8831
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 3200
Number of HSP's gapped (non-prelim): 2054
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.