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Search of human proteins with 19743796
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2
[Homo sapiens]
(281 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 ... 567 e-162
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 464 e-131
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 259 2e-69
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 231 4e-61
gi|31742501 sorting nexin family member 27 [Homo sapiens] 66 4e-11
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 56 3e-08
gi|21361142 PDZ domain containing 1 [Homo sapiens] 54 1e-07
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 51 1e-06
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 51 1e-06
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 51 1e-06
gi|148727255 microtubule associated serine/threonine kinase fami... 49 4e-06
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 47 1e-05
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 47 1e-05
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 47 1e-05
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 47 1e-05
gi|32171221 GRP1 (general receptor for phosphoinositides 1)-asso... 47 1e-05
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 47 2e-05
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 47 2e-05
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 47 2e-05
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 47 2e-05
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 46 4e-05
gi|47933392 cytohesin 1 interacting protein [Homo sapiens] 46 4e-05
gi|189571664 DEP domain containing 6 [Homo sapiens] 45 5e-05
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens] 45 5e-05
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 45 7e-05
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 45 7e-05
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 45 7e-05
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 45 9e-05
gi|21630285 PDZ domain containing 3 [Homo sapiens] 45 9e-05
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 44 2e-04
>gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2
[Homo sapiens]
Length = 281
Score = 567 bits (1461), Expect = e-162
Identities = 281/281 (100%), Positives = 281/281 (100%)
Query: 1 MMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADT 60
MMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADT
Sbjct: 1 MMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADT 60
Query: 61 PIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQG 120
PIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQG
Sbjct: 61 PIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQG 120
Query: 121 GNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKK 180
GNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKK
Sbjct: 121 GNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKK 180
Query: 181 KDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTV 240
KDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTV
Sbjct: 181 KDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTV 240
Query: 241 PGSPKAPFLGIPRGTMRRQKSIGKKCGTPPQKLPLGFQTQP 281
PGSPKAPFLGIPRGTMRRQKSIGKKCGTPPQKLPLGFQTQP
Sbjct: 241 PGSPKAPFLGIPRGTMRRQKSIGKKCGTPPQKLPLGFQTQP 281
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 464 bits (1194), Expect = e-131
Identities = 233/236 (98%), Positives = 234/236 (99%)
Query: 30 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 89
SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA
Sbjct: 618 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 677
Query: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP 149
GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP
Sbjct: 678 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP 737
Query: 150 KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI 209
KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI
Sbjct: 738 KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI 797
Query: 210 KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIGKK 265
KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSI +
Sbjct: 798 KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSR 853
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo
sapiens]
Length = 1747
Score = 259 bits (661), Expect = 2e-69
Identities = 144/249 (57%), Positives = 185/249 (74%), Gaps = 16/249 (6%)
Query: 18 YNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYL 77
Y G + +SD +I++K VLQK+D+EGFGFVLRGAKA+TPIEEFTPTPAFPALQYL
Sbjct: 567 YTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYL 626
Query: 78 ESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDP 137
ESVD GVAW+AGLRTGDFLIEVN NVVKVGH+QVV +IRQGGN LV+KVV+VTR +
Sbjct: 627 ESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPE- 685
Query: 138 DDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDK--PEEIVPASKPSR 195
+D AR++APPPPKRAP+T LTLRSKSMT+ELEEL AS+R++K + E + A++P+
Sbjct: 686 EDGARRRAPPPPKRAPSTTLTLRSKSMTAELEEL---ASIRRRKGEKLDEMLAAAAEPTL 742
Query: 196 AAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGT 255
+ + R AT+KQRP+SR ++++S++ERQG+ PG K P G R
Sbjct: 743 RPDIADADSRAATVKQRPTSRRI-TPAEISSLFERQGL-------PGPEKLP--GSLRKG 792
Query: 256 MRRQKSIGK 264
+ R KS+G+
Sbjct: 793 IPRTKSVGE 801
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
sapiens]
Length = 2161
Score = 231 bits (590), Expect = 4e-61
Identities = 135/247 (54%), Positives = 163/247 (65%), Gaps = 22/247 (8%)
Query: 30 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 89
SD II+EKTV+LQKKD+EGFGFVLRGAKA TPIEEFTPTPAFPALQYLESVDEGGVAW+A
Sbjct: 655 SDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRA 714
Query: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP 149
GLR GDFLIEVN +NVVKVGHRQVVNMIRQGGN L++KVV VTR+ D D+ KKAP
Sbjct: 715 GLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQA 774
Query: 150 KRAPTTALTLRSKSMTSELEEL------VDKASVRKKK-------DKPEEIVPASKPSRA 196
KR P ++LRSKSMTSELEE+ S+ KK+ +K +EI+ A++ + +
Sbjct: 775 KRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTIS 834
Query: 197 AENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTM 256
A +A++ + F S + + Q P + FL G M
Sbjct: 835 ASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQ---------PSYERPSFLPPGPGLM 885
Query: 257 RRQKSIG 263
RQKSIG
Sbjct: 886 LRQKSIG 892
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 65.9 bits (159), Expect = 4e-11
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Query: 39 VVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLI 98
VV K G+GF +RG ++ + LQ++ +V GG A +AG+R GD ++
Sbjct: 43 VVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRIL 102
Query: 99 EVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTV----TRNLDPDD 139
EVN+ NV H+QVV++IR G L+L V++V NLDP D
Sbjct: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSD 147
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/182 (27%), Positives = 73/182 (40%), Gaps = 29/182 (15%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K G+GF L G K QY+ V+ G A +AGL GD L+EVN
Sbjct: 18 EKGPNGYGFHLHGEKGKLG-------------QYIRLVEPGSPAEKAGLLAGDRLVEVNG 64
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSK 162
ENV K H+QVV+ IR N + L VV P ++ + +R +
Sbjct: 65 ENVEKETHQQVVSRIRAALNAVRLLVVD---------------PETDEQLQKLGVQVREE 109
Query: 163 SM-TSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAG 221
+ E + + + + E P E + PR+ T+K+ PS F
Sbjct: 110 LLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH 169
Query: 222 SD 223
SD
Sbjct: 170 SD 171
Score = 40.0 bits (92), Expect = 0.002
Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 13/87 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
KK G+GF L K+ Q++ SVD A +GLR D ++EVN
Sbjct: 158 KKGPSGYGFNLHSDKSKPG-------------QFIRSVDPDSPAEASGLRAQDRIVEVNG 204
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVV 129
+ H VV+ IR GG+ L VV
Sbjct: 205 VCMEGKQHGDVVSAIRAGGDETKLLVV 231
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 54.3 bits (129), Expect = 1e-07
Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 13/91 (14%)
Query: 39 VVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLI 98
+V KK + G+GF LR Q ++ +D G A +AGL+ D ++
Sbjct: 243 IVEMKKGSNGYGFYLRAGSEQKG-------------QIIKDIDSGSPAEEAGLKNNDLVV 289
Query: 99 EVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
VN E+V + H VV MIR+GG+ L VV
Sbjct: 290 AVNGESVETLDHDSVVEMIRKGGDQTSLLVV 320
Score = 44.7 bits (104), Expect = 9e-05
Identities = 20/54 (37%), Positives = 32/54 (59%)
Query: 76 YLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
Y+ + GVA +AG+ D LIEVN ENV H +VV +++ G+ ++ +V
Sbjct: 159 YMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLV 212
Score = 41.6 bits (96), Expect = 8e-04
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 41 LQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEV 100
L K++ + +GF LR IE+ T + V++ A +AGL+ GD ++ +
Sbjct: 12 LSKQEGQNYGFFLR-------IEKDTEG------HLVRVVEKCSPAEKAGLQDGDRVLRI 58
Query: 101 NNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
N V K H QVV+++R+ GN + L V+
Sbjct: 59 NGVFVDKEEHMQVVDLVRKSGNSVTLLVL 87
Score = 39.3 bits (90), Expect = 0.004
Identities = 20/53 (37%), Positives = 32/53 (60%)
Query: 76 YLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKV 128
+++ V +GG A AGL D +IEVN NV+ + +VV+ I+ G ++ L V
Sbjct: 402 FIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/96 (33%), Positives = 52/96 (54%), Gaps = 20/96 (20%)
Query: 25 RNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGG 84
R+ +Y + ++ V++QK DN GFG + G D P+ +++SV E G
Sbjct: 62 RSEIYG---LVQRCVIIQKDDN-GFGLTVSG---DNPV-------------FVQSVKEDG 101
Query: 85 VAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQG 120
A +AG++TGD +I+VN V H +VV +I+ G
Sbjct: 102 AAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSG 137
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 9/104 (8%)
Query: 35 EEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRT 93
E VVLQ+K+NEGFGFV+ +K P P + V EG A + G L+
Sbjct: 848 EPYDVVLQRKENEGFGFVILTSK------NKPPPGVIP--HKIGRVIEGSPADRCGKLKV 899
Query: 94 GDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDP 137
GD + VN +++V++ H +V +I+ G + L V+ + P
Sbjct: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/231 (22%), Positives = 91/231 (39%), Gaps = 48/231 (20%)
Query: 48 GFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVK 107
GFGF LRG K E+ L L ++G + GD ++E+N E
Sbjct: 1030 GFGFSLRGGK------EYNM-----GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQG 1078
Query: 108 VGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDD-------------TARKKAPPPPKRAPT 154
+ H + + +I+ GGN ++L + T L PD +++P PP +
Sbjct: 1079 ITHTRAIELIQAGGNKVLLLLRPGT-GLIPDHGDWDINNPSSSNVIYDEQSPLPPS---S 1134
Query: 155 TALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPS 214
++ +S +EE + + + +K ++ ++IVP K S EN + +++ S
Sbjct: 1135 HFASIFEESHVPVIEESL-RVQICEKAEELKDIVP-EKKSTLNENQPEIKHQSLLQKNVS 1192
Query: 215 SRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIGKK 265
R P+ S K L + G RR +S+ K
Sbjct: 1193 KRDPPSSHG------------------HSNKKNLLKVENGVTRRGRSVSPK 1225
Score = 33.1 bits (74), Expect = 0.28
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 17/76 (22%)
Query: 44 KDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNE 103
K +GFGF + AD+P + L+S W GL+ GD + E+ ++
Sbjct: 583 KGPKGFGFAI----ADSPTGQ-------KVKMILDS------QWCQGLQKGDIIKEIYHQ 625
Query: 104 NVVKVGHRQVVNMIRQ 119
NV + H QVV +++Q
Sbjct: 626 NVQNLTHLQVVEVLKQ 641
Score = 32.0 bits (71), Expect = 0.62
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
KK GFGF + G D P +EF LQ + +G A + GD ++++N
Sbjct: 414 KKSTMGFGFTIIGG--DRP-DEF--------LQVKNVLKDGPAAQDGKIAPGDVIVDING 462
Query: 103 ENVVKVGHRQVVNMIR 118
V+ H VV M +
Sbjct: 463 NCVLGHTHADVVQMFQ 478
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 9/104 (8%)
Query: 35 EEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRT 93
E VVLQ+K+NEGFGFV+ +K P P + V EG A + G L+
Sbjct: 848 EPYDVVLQRKENEGFGFVILTSK------NKPPPGVIP--HKIGRVIEGSPADRCGKLKV 899
Query: 94 GDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDP 137
GD + VN +++V++ H +V +I+ G + L V+ + P
Sbjct: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 38.9 bits (89), Expect = 0.005
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 11/79 (13%)
Query: 48 GFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVK 107
GFGF LRG K E+ L L ++G + GD ++E+N E
Sbjct: 1030 GFGFSLRGGK------EYNM-----GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQG 1078
Query: 108 VGHRQVVNMIRQGGNHLVL 126
+ H + + +I+ GGN ++L
Sbjct: 1079 ITHTRAIELIQAGGNKVLL 1097
Score = 33.1 bits (74), Expect = 0.28
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 17/76 (22%)
Query: 44 KDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNE 103
K +GFGF + AD+P + L+S W GL+ GD + E+ ++
Sbjct: 583 KGPKGFGFAI----ADSPTGQ-------KVKMILDS------QWCQGLQKGDIIKEIYHQ 625
Query: 104 NVVKVGHRQVVNMIRQ 119
NV + H QVV +++Q
Sbjct: 626 NVQNLTHLQVVEVLKQ 641
Score = 32.0 bits (71), Expect = 0.62
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
KK GFGF + G D P +EF LQ + +G A + GD ++++N
Sbjct: 414 KKSTMGFGFTIIGG--DRP-DEF--------LQVKNVLKDGPAAQDGKIAPGDVIVDING 462
Query: 103 ENVVKVGHRQVVNMIR 118
V+ H VV M +
Sbjct: 463 NCVLGHTHADVVQMFQ 478
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 49.3 bits (116), Expect = 4e-06
Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 30/217 (13%)
Query: 79 SVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPD 138
+V+EG A QAGL+ GD + +N E V + H +V+ ++ + GN + +T T P
Sbjct: 987 NVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKV---SITTT----PF 1039
Query: 139 DTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDK-PEEIVPASKPSR-- 195
+ K P + + + + RSK + + E L + S+ KK K P ++ S+
Sbjct: 1040 ENTSIKTGPARRNSYKSRMVRRSKK-SKKKESLERRRSLFKKLAKQPSPLLHTSRSFSCL 1098
Query: 196 -----------AAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSP 244
+ ++ PR T R S+ FP+G++ + A +P G
Sbjct: 1099 NRSLSSGESLPGSPTHSLSPRSPTPSYR-STPDFPSGTNSSQSSSPSSSAPNSPAGSGHI 1157
Query: 245 K-------APFLGIPRGTMRRQKSIGKKCGTPPQKLP 274
+ AP LG R R+KS G +P + P
Sbjct: 1158 RPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLARTP 1194
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 47.4 bits (111), Expect = 1e-05
Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 34/171 (19%)
Query: 36 EKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGD 95
++ V++QK D GFGF + G + + ++SV GG A +AG++ GD
Sbjct: 45 QRCVIIQK-DQHGFGFTVSGDR----------------IVLVQSVRPGGAAMKAGVKEGD 87
Query: 96 FLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNL-------DPDDTARKK---- 144
+I+VN V H +VV +I+ G + + + ++ DP +
Sbjct: 88 RIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSV 147
Query: 145 ---APPPPKRAPTTALTLRSKSMTSELEE---LVDKASVRKKKDKPEEIVP 189
PPPP P +T E+++ + + +R+++ + ++I+P
Sbjct: 148 IPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILP 198
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 47.4 bits (111), Expect = 1e-05
Identities = 33/125 (26%), Positives = 62/125 (49%), Gaps = 19/125 (15%)
Query: 7 GGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFT 66
GGG + V+ T +++ V +++ +NEGFGFV+ + P T
Sbjct: 955 GGGGSGVVST----------------VVQPYDVEIRRGENEGFGFVIVSS-VSRPEAGTT 997
Query: 67 PTPAFPALQY-LESVDEGGVAWQAG-LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHL 124
A A+ + + + EG A + G L+ GD ++ VN ++ H +VN+I++ GN +
Sbjct: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
Query: 125 VLKVV 129
L+++
Sbjct: 1058 TLRII 1062
Score = 38.5 bits (88), Expect = 0.007
Identities = 35/145 (24%), Positives = 64/145 (44%), Gaps = 21/145 (14%)
Query: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQ--GGNHLVLKVVTVTRNLDPDDTARKKAPP 147
GL+ GD ++EVN +NV + H QVV+M+ + G+ + L V ++ P
Sbjct: 679 GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV-------------QRGGLP 725
Query: 148 PPKRAPTTALTLRSKSMTSELEELVDKASVR-KKKDKPEEIVPASKPSRAAENMAVEPRV 206
PK++P + R S S + S+ +++P P AE A +
Sbjct: 726 VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPP---AEAQAPDQTD 782
Query: 207 ATIKQRPSSRCFPAGSDMNSVYERQ 231
++ +++P F + S+YE +
Sbjct: 783 SSGQKKPDP--FKIWAQSRSMYENR 805
Score = 37.4 bits (85), Expect = 0.015
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 13/81 (16%)
Query: 47 EGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRTGDFLIEVNNENV 105
+GFGF LRG + + Y+ + E G A + G +R GD ++E+N E
Sbjct: 1131 KGFGFSLRGGRE------------YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178
Query: 106 VKVGHRQVVNMIRQGGNHLVL 126
+ H + + +I+ GG + L
Sbjct: 1179 KNMKHSRAIELIKNGGRRVRL 1199
Score = 34.3 bits (77), Expect = 0.13
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K + GFGF + G D P +EF LQ V +G A + TGD ++ VN+
Sbjct: 476 RKSSRGFGFTVVGG--DEP-DEF--------LQIKSLVLDGPAALDGKMETGDVIVSVND 524
Query: 103 ENVVKVGHRQVVNMIR 118
V+ H QVV + +
Sbjct: 525 TCVLGHTHAQVVKIFQ 540
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 47.4 bits (111), Expect = 1e-05
Identities = 33/125 (26%), Positives = 62/125 (49%), Gaps = 19/125 (15%)
Query: 7 GGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFT 66
GGG + V+ T +++ V +++ +NEGFGFV+ + P T
Sbjct: 983 GGGGSGVVST----------------VVQPYDVEIRRGENEGFGFVIVSS-VSRPEAGTT 1025
Query: 67 PTPAFPALQY-LESVDEGGVAWQAG-LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHL 124
A A+ + + + EG A + G L+ GD ++ VN ++ H +VN+I++ GN +
Sbjct: 1026 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
Query: 125 VLKVV 129
L+++
Sbjct: 1086 TLRII 1090
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 31/173 (17%)
Query: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQ--GGNHLVLKVVTVTRNLDPDDTARKKAPP 147
GL+ GD ++EVN +NV + H QVV+M+ + G+ + L V ++ P
Sbjct: 679 GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV-------------QRGGLP 725
Query: 148 PPKRAPTTALTLRSKSMTSELEELVDKASVR-KKKDKPEEIVPASKPSRAAENMAVEPRV 206
PK++P + R S S + S+ +++P P AE A +
Sbjct: 726 VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPP---AEAQAPDQTD 782
Query: 207 ATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQ 259
++ +++P F + S+YE + P SP +P G+ +G R+
Sbjct: 783 SSGQKKPDP--FKIWAQSRSMYENR---------PMSP-SPASGLSKGERERE 823
Score = 37.4 bits (85), Expect = 0.015
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 13/81 (16%)
Query: 47 EGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRTGDFLIEVNNENV 105
+GFGF LRG + + Y+ + E G A + G +R GD ++E+N E
Sbjct: 1159 KGFGFSLRGGRE------------YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1206
Query: 106 VKVGHRQVVNMIRQGGNHLVL 126
+ H + + +I+ GG + L
Sbjct: 1207 KNMKHSRAIELIKNGGRRVRL 1227
Score = 34.3 bits (77), Expect = 0.13
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K + GFGF + G D P +EF LQ V +G A + TGD ++ VN+
Sbjct: 476 RKSSRGFGFTVVGG--DEP-DEF--------LQIKSLVLDGPAALDGKMETGDVIVSVND 524
Query: 103 ENVVKVGHRQVVNMIR 118
V+ H QVV + +
Sbjct: 525 TCVLGHTHAQVVKIFQ 540
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 47.4 bits (111), Expect = 1e-05
Identities = 37/118 (31%), Positives = 55/118 (46%), Gaps = 35/118 (29%)
Query: 37 KTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQY-------------------- 76
KTV L K+ ++GFGF LR F P A+Q+
Sbjct: 49 KTVTL-KRTSQGFGFTLR---------HFIVYPPESAIQFSYKDEENGNRGGKQRNRLEP 98
Query: 77 -----LESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
++ V EGG A++AGL TGD +I+VN E+V+ + QV+ +I+ L L V+
Sbjct: 99 MDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVM 156
>gi|32171221 GRP1 (general receptor for phosphoinositides
1)-associated scaffold protein [Homo sapiens]
Length = 395
Score = 47.4 bits (111), Expect = 1e-05
Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 35 EEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTG 94
+ K + L+K+DN+ FGF ++ E+ F V E A AGL G
Sbjct: 98 QRKVLTLEKEDNQTFGFEIQTYGLHHREEQRVEMVTFVC-----RVHESSPAQLAGLTPG 152
Query: 95 DFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
D + VN NV + HR++V++I+ GN L L+ +
Sbjct: 153 DTIASVNGLNVEGIRHREIVDIIKASGNVLRLETL 187
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 47.0 bits (110), Expect = 2e-05
Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 29 YSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ 88
YS + ++ + ++ + +GF LR + T + + V+EGG A +
Sbjct: 957 YSPAVSGLRSPITIQRSGKKYGFTLRAIRV-----YMGDTDVYSVHHIVWHVEEGGPAQE 1011
Query: 89 AGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPP 148
AGL GD + VN E V + H +VV +I + GN + VT T P + + P
Sbjct: 1012 AGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKV---AVTTT----PFENTSIRIGPA 1064
Query: 149 PKRAPTTALTLRSKSMTS-ELEELVDKASVRKKKDKPEEIVPASK 192
+ + + R+K ++ E +E ++S+ +K K ++ S+
Sbjct: 1065 RRSSYKAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSR 1109
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 47.0 bits (110), Expect = 2e-05
Identities = 31/125 (24%), Positives = 61/125 (48%), Gaps = 18/125 (14%)
Query: 7 GGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFT 66
GGG + V+ T +++ V +++ +NEGFGFV+ + +
Sbjct: 983 GGGGSGVVST----------------VVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTF 1026
Query: 67 PTPAFPALQY-LESVDEGGVAWQAG-LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHL 124
A A+ + + + EG A + G L+ GD ++ VN ++ H +VN+I++ GN +
Sbjct: 1027 AGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1086
Query: 125 VLKVV 129
L+++
Sbjct: 1087 TLRII 1091
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 31/173 (17%)
Query: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQ--GGNHLVLKVVTVTRNLDPDDTARKKAPP 147
GL+ GD ++EVN +NV + H QVV+M+ + G+ + L V ++ P
Sbjct: 679 GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV-------------QRGGLP 725
Query: 148 PPKRAPTTALTLRSKSMTSELEELVDKASVR-KKKDKPEEIVPASKPSRAAENMAVEPRV 206
PK++P + R S S + S+ +++P P AE A +
Sbjct: 726 VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPP---AEAQAPDQTD 782
Query: 207 ATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQ 259
++ +++P F + S+YE + P SP +P G+ +G R+
Sbjct: 783 SSGQKKPDP--FKIWAQSRSMYENR---------PMSP-SPASGLSKGERERE 823
Score = 37.4 bits (85), Expect = 0.015
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 13/81 (16%)
Query: 47 EGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRTGDFLIEVNNENV 105
+GFGF LRG + + Y+ + E G A + G +R GD ++E+N E
Sbjct: 1160 KGFGFSLRGGRE------------YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1207
Query: 106 VKVGHRQVVNMIRQGGNHLVL 126
+ H + + +I+ GG + L
Sbjct: 1208 KNMKHSRAIELIKNGGRRVRL 1228
Score = 34.3 bits (77), Expect = 0.13
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K + GFGF + G D P +EF LQ V +G A + TGD ++ VN+
Sbjct: 476 RKSSRGFGFTVVGG--DEP-DEF--------LQIKSLVLDGPAALDGKMETGDVIVSVND 524
Query: 103 ENVVKVGHRQVVNMIR 118
V+ H QVV + +
Sbjct: 525 TCVLGHTHAQVVKIFQ 540
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 47.0 bits (110), Expect = 2e-05
Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 10/115 (8%)
Query: 79 SVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPD 138
SV++G A +AGLR GD + +N E+V+ + H VV ++ + GN + L+ +
Sbjct: 985 SVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTAL------- 1037
Query: 139 DTARKKAPPPPKRAPTTALTLRSKSMTSELEELVD-KASVRKKKDKPEEIVPASK 192
+ K P K + RSK S E D + S+ KK K ++ S+
Sbjct: 1038 ENTSIKVGPARKNVAKGRMARRSK--RSRRRETQDRRKSLFKKISKQTSVLHTSR 1090
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 46.6 bits (109), Expect = 2e-05
Identities = 27/85 (31%), Positives = 44/85 (51%), Gaps = 17/85 (20%)
Query: 36 EKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGD 95
++ V++QK D GFGF + G + + ++SV GG A +AG++ GD
Sbjct: 45 QRCVIIQK-DQHGFGFTVSGDR----------------IVLVQSVRPGGAAMKAGVKEGD 87
Query: 96 FLIEVNNENVVKVGHRQVVNMIRQG 120
+I+VN V H +VV +I+ G
Sbjct: 88 RIIKVNGTMVTNSSHLEVVKLIKSG 112
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 45.8 bits (107), Expect = 4e-05
Identities = 33/114 (28%), Positives = 55/114 (48%), Gaps = 8/114 (7%)
Query: 80 VDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDD 139
V++GG A +AGLR GD + VN E V + H +VV +I + GN + + P +
Sbjct: 1140 VEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTT-------PLE 1192
Query: 140 TARKKAPPPPKRAPTTALTLRSK-SMTSELEELVDKASVRKKKDKPEEIVPASK 192
K P K + + RSK S + +E ++S+ +K K ++ S+
Sbjct: 1193 NTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSR 1246
>gi|47933392 cytohesin 1 interacting protein [Homo sapiens]
Length = 359
Score = 45.8 bits (107), Expect = 4e-05
Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 35 EEKTVVLQKKDNEGFGFVLRGAKADTP----IEEFTPTPAFPALQYLESVDEGGVAWQAG 90
+ K V ++K+DNE FGF ++ + E FT + + E A AG
Sbjct: 74 QRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFT---------LICKIQEDSPAHCAG 124
Query: 91 LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVT 132
L+ GD L +N + ++QVV++IR GN L ++ + T
Sbjct: 125 LQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTIETLNGT 166
>gi|189571664 DEP domain containing 6 [Homo sapiens]
Length = 409
Score = 45.4 bits (106), Expect = 5e-05
Identities = 27/85 (31%), Positives = 45/85 (52%), Gaps = 16/85 (18%)
Query: 45 DNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNEN 104
D G+GFV+RG+K ++++VD G A AG++ F++ VN N
Sbjct: 336 DAVGWGFVVRGSKPC----------------HIQAVDPSGPAAAAGMKVCQFVVSVNGLN 379
Query: 105 VVKVGHRQVVNMIRQGGNHLVLKVV 129
V+ V +R V N+I G +V++V+
Sbjct: 380 VLHVDYRTVSNLILTGPRTIVMEVM 404
>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
Length = 977
Score = 45.4 bits (106), Expect = 5e-05
Identities = 38/160 (23%), Positives = 69/160 (43%), Gaps = 10/160 (6%)
Query: 86 AWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKA 145
A +AGLR D L+ +N + + H +++I GN LVL V + D ++
Sbjct: 42 AGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRLA------DEGPVQS 95
Query: 146 PPPPKRAPTTALT-LRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEP 204
P P + + L+ L + + + + + S+R P+ + A+ A +
Sbjct: 96 PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLR---SPPDSEAYYGETDSDADGPATQE 152
Query: 205 RVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSP 244
+ ++R +R P G+ + VY A PT+PG P
Sbjct: 153 KPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPP 192
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 45.1 bits (105), Expect = 7e-05
Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 34 IEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ-AGLR 92
++ VV+ +K+NEGFGFV+ + + P T T + + +G A + A L+
Sbjct: 916 LQTSDVVIHRKENEGFGFVII-SSLNRPESGSTIT----VPHKIGRIIDGSPADRCAKLK 970
Query: 93 TGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRA 152
GD ++ VN ++++ + H +V +I+ G + L+++ P AP K++
Sbjct: 971 VGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSP-----TSAPSSEKQS 1025
Query: 153 P 153
P
Sbjct: 1026 P 1026
Score = 38.9 bits (89), Expect = 0.005
Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 18/110 (16%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
KK N GFGF + G D P +EF LQ + +G A + TGD ++ +N
Sbjct: 430 KKSNMGFGFTIIG--GDEP-DEF--------LQVKSVIPDGPAAQDGKMETGDVIVYINE 478
Query: 103 ENVVKVGHRQVVNM-----IRQGGNHLVLKVVTVTRNLDPDDTARKKAPP 147
V+ H VV + I Q N ++ + + DP+D A PP
Sbjct: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLP--FDPEDPANSMVPP 526
Score = 38.9 bits (89), Expect = 0.005
Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 17/114 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K +GFGF +RG + E+ L L ++G +R GD +IE+N
Sbjct: 1151 EKGAKGFGFSIRGGR------EYKMD-----LYVLRLAEDGPAIRNGRMRVGDQIIEING 1199
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTA 156
E+ + H + + +I+ GG + L + T + D P P +P A
Sbjct: 1200 ESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYD------EPAPWSSPAAA 1247
Score = 33.1 bits (74), Expect = 0.28
Identities = 17/75 (22%), Positives = 33/75 (44%), Gaps = 17/75 (22%)
Query: 44 KDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNE 103
K +GFGF + + +++ P GL GD ++E+N +
Sbjct: 610 KGAQGFGFTIADSPTGQRVKQILDIQGCP-----------------GLCEGDLIVEINQQ 652
Query: 104 NVVKVGHRQVVNMIR 118
NV + H +VV++++
Sbjct: 653 NVQNLSHTEVVDILK 667
Score = 28.9 bits (63), Expect = 5.3
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 76 YLESVDEGGVAWQAG--LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTR 133
YL V G VA+++G L + + L+EVN V + R V+ +I+ + L LK V
Sbjct: 43 YLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGG 102
Query: 134 NLDPD 138
+D D
Sbjct: 103 IVDKD 107
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 45.1 bits (105), Expect = 7e-05
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 13/87 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K +G+GF L K+ QY+ SVD G A ++GLR D LIEVN
Sbjct: 155 RKGPQGYGFNLHSDKSRPG-------------QYIRSVDPGSPAARSGLRAQDRLIEVNG 201
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVV 129
+NV + H +VV I+ + L VV
Sbjct: 202 QNVEGLRHAEVVASIKAREDEARLLVV 228
Score = 40.8 bits (94), Expect = 0.001
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 13/75 (17%)
Query: 44 KDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNE 103
+ +G+GF L G K Q++ V+ G A A LR GD L+EVN
Sbjct: 16 RGEQGYGFHLHGEKGRRG-------------QFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
Query: 104 NVVKVGHRQVVNMIR 118
NV H QVV I+
Sbjct: 63 NVEGETHHQVVQRIK 77
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 45.1 bits (105), Expect = 7e-05
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 13/87 (14%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K +G+GF L K+ QY+ SVD G A ++GLR D LIEVN
Sbjct: 155 RKGPQGYGFNLHSDKSRPG-------------QYIRSVDPGSPAARSGLRAQDRLIEVNG 201
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVV 129
+NV + H +VV I+ + L VV
Sbjct: 202 QNVEGLRHAEVVASIKAREDEARLLVV 228
Score = 40.8 bits (94), Expect = 0.001
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 13/75 (17%)
Query: 44 KDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNE 103
+ +G+GF L G K Q++ V+ G A A LR GD L+EVN
Sbjct: 16 RGEQGYGFHLHGEKGRRG-------------QFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
Query: 104 NVVKVGHRQVVNMIR 118
NV H QVV I+
Sbjct: 63 NVEGETHHQVVQRIK 77
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 44.7 bits (104), Expect = 9e-05
Identities = 21/54 (38%), Positives = 37/54 (68%)
Query: 76 YLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
++++V E G A +AGLRTGD L++VN E+V+ + QV+ +I+ + L L ++
Sbjct: 5 FVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIM 58
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 44.7 bits (104), Expect = 9e-05
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 43 KKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNN 102
+K +GFGF+LR K P Q+L VD G A +AG++ GD L+ V
Sbjct: 253 EKGPQGFGFLLREEKG------LDGRPG----QFLWEVDPGLPAKKAGMQAGDRLVAVAG 302
Query: 103 ENVVKVGHRQVVNMIRQGGNHLVLKVV 129
E+V +GH + V+ I+ G+ + L VV
Sbjct: 303 ESVEGLGHEETVSRIQGQGSCVSLTVV 329
Score = 31.6 bits (70), Expect = 0.81
Identities = 18/50 (36%), Positives = 27/50 (54%)
Query: 80 VDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV 129
VD G A + GL+ GD ++ VNN+ V + VV IR ++L V+
Sbjct: 78 VDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVL 127
Score = 29.3 bits (64), Expect = 4.0
Identities = 12/26 (46%), Positives = 18/26 (69%)
Query: 76 YLESVDEGGVAWQAGLRTGDFLIEVN 101
++ V GG A +AGL+ GD ++EVN
Sbjct: 412 FISQVTPGGSAARAGLQVGDVILEVN 437
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 43.5 bits (101), Expect = 2e-04
Identities = 44/169 (26%), Positives = 68/169 (40%), Gaps = 30/169 (17%)
Query: 48 GFGFVLRGAK---ADTPIEEFTPTPAFPALQYLESVDEGGVAWQAG-LRTGDFLIEVNNE 103
GFG L G + DTP+ + + + G A + G L GD ++ +N E
Sbjct: 134 GFGLTLGGGRDVAGDTPLA-------------VRGLLKDGPAQRCGRLEVGDLVLHINGE 180
Query: 104 NVVKVGHRQVVNMIRQGGN--HLVLKVVTVTRNLDPDDTARKK---APPPPKRAPTTA-- 156
+ + H Q V IR GG HLV++ T P + P P R+P
Sbjct: 181 STQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGP 240
Query: 157 -LTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEP 204
+T S TS ++ + +++K + PE P AA+ V P
Sbjct: 241 EVTGSRSSSTSLVQHPPSRTTLKKTRGSPE-----PSPEAAADGPTVSP 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,649,912
Number of Sequences: 37866
Number of extensions: 627324
Number of successful extensions: 2300
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 1999
Number of HSP's gapped (non-prelim): 380
length of query: 281
length of database: 18,247,518
effective HSP length: 101
effective length of query: 180
effective length of database: 14,423,052
effective search space: 2596149360
effective search space used: 2596149360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.