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Search of human proteins with 197304786
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo
sapiens]
(1114 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 2262 0.0
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 1840 0.0
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 1083 0.0
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 999 0.0
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 605 e-172
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 167 4e-41
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 167 4e-41
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 161 3e-39
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 161 3e-39
gi|4758968 cytohesin 3 [Homo sapiens] 161 4e-39
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 159 1e-38
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 152 1e-36
gi|7019505 cytohesin 4 [Homo sapiens] 146 9e-35
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 137 7e-32
gi|48928044 F-box only protein 8 [Homo sapiens] 106 1e-22
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 93 1e-18
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 90 1e-17
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 89 2e-17
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 89 2e-17
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 89 3e-17
gi|4504489 histidine-rich glycoprotein precursor [Homo sapiens] 76 2e-13
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens] 65 3e-10
gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 60 9e-09
gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 60 9e-09
gi|24497504 forkhead box A2 isoform 2 [Homo sapiens] 58 6e-08
gi|194394143 forkhead box A2 isoform 1 [Homo sapiens] 58 6e-08
gi|23308699 transcription factor MAFB [Homo sapiens] 57 1e-07
gi|59938776 cAMP responsive element binding protein 5 isoform de... 56 2e-07
gi|59938774 cAMP responsive element binding protein 5 isoform be... 56 2e-07
gi|59938772 cAMP responsive element binding protein 5 isoform ga... 56 2e-07
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 2262 bits (5861), Expect = 0.0
Identities = 1114/1114 (100%), Positives = 1114/1114 (100%)
Query: 1 MACRRRYFVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPG 60
MACRRRYFVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPG
Sbjct: 1 MACRRRYFVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPG 60
Query: 61 QQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVT 120
QQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVT
Sbjct: 61 QQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVT 120
Query: 121 RHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEG 180
RHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEG
Sbjct: 121 RHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEG 180
Query: 181 KQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESI 240
KQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESI
Sbjct: 181 KQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESI 240
Query: 241 DDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSP 300
DDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSP
Sbjct: 241 DDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSP 300
Query: 301 PLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRV 360
PLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRV
Sbjct: 301 PLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRV 360
Query: 361 EHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREE 420
EHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREE
Sbjct: 361 EHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREE 420
Query: 421 PELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDS 480
PELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDS
Sbjct: 421 PELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDS 480
Query: 481 LREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPD 540
LREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPD
Sbjct: 481 LREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPD 540
Query: 541 TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAH 600
TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAH
Sbjct: 541 TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAH 600
Query: 601 IRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPE 660
IRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPE
Sbjct: 601 IRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPE 660
Query: 661 RKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKP 720
RKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKP
Sbjct: 661 RKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKP 720
Query: 721 IGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKK 780
IGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKK
Sbjct: 721 IGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKK 780
Query: 781 KNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFT 840
KNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFT
Sbjct: 781 KNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFT 840
Query: 841 DDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASG 900
DDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASG
Sbjct: 841 DDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASG 900
Query: 901 EGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQ 960
EGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQ
Sbjct: 901 EGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQ 960
Query: 961 TMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLP 1020
TMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLP
Sbjct: 961 TMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLP 1020
Query: 1021 QAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLP 1080
QAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLP
Sbjct: 1021 QAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLP 1080
Query: 1081 SAHVGHTVHHHGQPPAPPPPTSSKAKPSGISTIV 1114
SAHVGHTVHHHGQPPAPPPPTSSKAKPSGISTIV
Sbjct: 1081 SAHVGHTVHHHGQPPAPPPPTSSKAKPSGISTIV 1114
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 1840 bits (4765), Expect = 0.0
Identities = 927/927 (100%), Positives = 927/927 (100%)
Query: 9 VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 68
VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP
Sbjct: 23 VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 82
Query: 69 KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 128
KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ
Sbjct: 83 KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 142
Query: 129 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND 188
TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND
Sbjct: 143 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND 202
Query: 189 GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS 248
GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS
Sbjct: 203 GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS 262
Query: 249 LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG 308
LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG
Sbjct: 263 LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG 322
Query: 309 DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI 368
DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI
Sbjct: 323 DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI 382
Query: 369 EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP 428
EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP
Sbjct: 383 EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP 442
Query: 429 RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK 488
RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK
Sbjct: 443 RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK 502
Query: 489 QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF 548
QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF
Sbjct: 503 QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF 562
Query: 549 LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ 608
LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ
Sbjct: 563 LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ 622
Query: 609 KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF 668
KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF
Sbjct: 623 KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF 682
Query: 669 IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL 728
IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL
Sbjct: 683 IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL 742
Query: 729 GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF 788
GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF
Sbjct: 743 GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF 802
Query: 789 RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA 848
RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA
Sbjct: 803 RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA 862
Query: 849 EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL 908
EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL
Sbjct: 863 EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL 922
Query: 909 SSSLRDLSEAGKRGRRSSAGSLESNVE 935
SSSLRDLSEAGKRGRRSSAGSLESNVE
Sbjct: 923 SSSLRDLSEAGKRGRRSSAGSLESNVE 949
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 1083 bits (2802), Expect = 0.0
Identities = 657/1199 (54%), Positives = 789/1199 (65%), Gaps = 152/1199 (12%)
Query: 5 RRYFVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQR 64
R VEG+AP S+ T++DSP + P L S P H G+ G P Q
Sbjct: 243 RTVSVEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ-- 294
Query: 65 TRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAA 124
R +LQ ++ LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG ++R AA
Sbjct: 295 --RARLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAA 351
Query: 125 RTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQV 183
RTIQTAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE EK + +YFEGK
Sbjct: 352 RTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPA 411
Query: 184 SVTNDGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVK 234
S+ ++G+ GA CG + S S +F++ ITELED+FS+QVK
Sbjct: 412 SL-DEGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVK 469
Query: 235 SLAESIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYI 293
SLAESID+ALNC S E P R+++ Q D S+SD+ LY+
Sbjct: 470 SLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYL 520
Query: 294 DEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADT 341
D+ +P Q+ +R STE + R P++WA A +ED +
Sbjct: 521 DDT-----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSRE 569
Query: 342 DTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQ 401
+ + R LE ++ RLR HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ YE
Sbjct: 570 EGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPH 629
Query: 402 GSPKH-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES-- 449
G+ KH GP AP + P E P PP PL +S +G A R K E+
Sbjct: 630 GTLKHKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG 688
Query: 450 DYSDG-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFS 505
+ SDG DN+S+ S+SNSN+TINCSS SSSRDSLRE L KQTY +E R+SWDSPAF+
Sbjct: 689 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN 748
Query: 506 NDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLG 565
NDV+++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLG
Sbjct: 749 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG 808
Query: 566 NRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICN 625
NRQKQFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CN
Sbjct: 809 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN 868
Query: 626 PGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREM 685
P +VRQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++
Sbjct: 869 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL 928
Query: 686 LMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRL 745
L+GIY+RI+ REL+TN+DHVSQVQ VE++IVGKKP VLSLPHRRLVC C+L
Sbjct: 929 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQL 978
Query: 746 FEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQ 805
+EVPDPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK VTYSFRQSF L M + LF+N
Sbjct: 979 YEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNS 1038
Query: 806 YYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQ 865
YY GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQ
Sbjct: 1039 YYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQ 1098
Query: 866 KGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRS 925
KG++RP+ SQ K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AGKRGRR+
Sbjct: 1099 KGMMRPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRN 1157
Query: 926 SAGSLESNVEGSIISSPHMRRRATSTRECPS----RPHQTMPNSSSLLGSLFGSKRGK-- 979
S GSL+S +EGS+ISSP +R P + + + NSSS LGSLFGSKRGK
Sbjct: 1158 SVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGP 1217
Query: 980 ---PPP---QAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLP--QAAMHGHHTQY 1031
PPP QA S+ A H H H GH G LP Q+ + H QY
Sbjct: 1218 FQMPPPPTGQASASSSSASSTHH------HHHHHHHGHSHGGLGVLPDGQSKLQALHAQY 1271
Query: 1032 CHMQN--PPPY------------------------------------HHHHHHHPPQHIQ 1053
C PPPY H H H H P +
Sbjct: 1272 CQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGP--VP 1329
Query: 1054 HAHQYHHGPHGGHPAYGAHAHGHPPLPSAHVGHTVHHHGQP-----PAPPPPTSSKAKP 1107
Y G G P GA H P + H H +H P PAP P + K P
Sbjct: 1330 GPQHYTLGRPGRAPRRGAGGH---PQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGP 1385
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 999 bits (2584), Expect = 0.0
Identities = 575/950 (60%), Positives = 692/950 (72%), Gaps = 84/950 (8%)
Query: 9 VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 68
VEG+AP S+ T++DSP + P L S P H G+ G P Q R
Sbjct: 42 VEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ----RA 91
Query: 69 KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 128
+LQ ++ LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG ++R AARTIQ
Sbjct: 92 RLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQ 150
Query: 129 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVSVTN 187
TAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE EK + +YFEGK S+ +
Sbjct: 151 TAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASL-D 209
Query: 188 DGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAE 238
+G+ GA CG + S S +F++ ITELED+FS+QVKSLAE
Sbjct: 210 EGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKSLAE 268
Query: 239 SIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEE 297
SID+ALNC S E P R+++ Q D S+SD+ LY+D+
Sbjct: 269 SIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLDDT- 318
Query: 298 LSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTDTSC 345
+P Q+ +R STE + R P++WA A +ED + + +
Sbjct: 319 ----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREEGTR 368
Query: 346 RSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPK 405
R LE ++ RLR HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ YE G+ K
Sbjct: 369 RGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK 428
Query: 406 H-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--DYSD 453
H GP AP + P E P PP PL +S +G A R K E+ + SD
Sbjct: 429 HKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD 487
Query: 454 G-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSNDVI 509
G DN+S+ S+SNSN+TINCSS SSSRDSLRE L KQTY +E R+SWDSPAF+NDV+
Sbjct: 488 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 547
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGNRQK
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
QFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP +V
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
RQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L+GI
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
Query: 690 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 749
Y+RI+ REL+TN+DHVSQVQ VE++IVGKKP VLSLPHRRLVC C+L+EVP
Sbjct: 728 YQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLYEVP 777
Query: 750 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 809
DPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK VTYSFRQSF L M + LF+N YY
Sbjct: 778 DPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQF 837
Query: 810 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 869
GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQKG++
Sbjct: 838 GIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMM 897
Query: 870 RPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAG 919
RP+ SQ K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AG
Sbjct: 898 RPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAG 946
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 605 bits (1559), Expect = e-172
Identities = 368/789 (46%), Positives = 470/789 (59%), Gaps = 102/789 (12%)
Query: 109 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 168
MLE KYGG LV+R AA TIQTAFRQYQ++KNFE++R+S+ E+R+ RRI L +R
Sbjct: 1 MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVR------ 54
Query: 169 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 228
S T + + G + P ++SP+ FA +TELED+
Sbjct: 55 ---------------SPTAESLAAEKALMEGYGLVGLPL-VRSPSLPPTFAGTLTELEDS 98
Query: 229 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 288
F+ QV+SLA+SID DA + +L +L +
Sbjct: 99 FTEQVQSLAKSID----------------DALSTWSLKTMCSLRESGAYQLHQAL----- 137
Query: 289 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 348
QA P E++ G AP+ +D A+T
Sbjct: 138 -----------------QAAAGPPGLEAE------GRAPESAGPGPGDDAAET------- 167
Query: 349 PSLERQEQRLRVEHLPLLTIEPPSD-----SSVDLSDRSERGSLKRQSAYERSLGGQQGS 403
P L + +T++ + SS LS + G+ Q+ E + G +
Sbjct: 168 PGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQG 227
Query: 404 PKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSD---------- 453
G + ++ RE+ S A +A + + E +
Sbjct: 228 ETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287
Query: 454 -GDNDSINSTSNSNDTINCSSESS---SRDSLREQTLSKQTYHKEARNSWDSPAFSNDVI 509
GD + ++S+S S + SE+S S+D+L+ LS YH E S SP S D +
Sbjct: 288 AGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTL 347
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
RKR YRIGLNLFN P+KG+Q+LI RGF+PDTP+GVAHFLLQRKGLSRQMIGEFLGN +K
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
QFNRDVLDCVVDEMDFS+MELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYC+CNP VV
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
+QF NPDTIFILAFAIILLNTDMYSPN+KP+RKM LEDFI+NLRGVDDG DIPRE+++GI
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
Query: 690 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 749
YERI+++ELK+NEDHV+ V KVEK IVG K VLS+PHRRLVC RLFEV
Sbjct: 528 YERIQQKELKSNEDHVTYVTKVEKSIVGMK----------TVLSVPHRRLVCCSRLFEVT 577
Query: 750 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 809
D NK QK HQRE+FLFNDLLV+ K+ KKK+S TY+F +S L GMQ LFEN+YY +
Sbjct: 578 DVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSH 637
Query: 810 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 869
GI L + + G++ K +++F A + +KF +DL+ESIAEV E+E+ RIE ELEKQ+G
Sbjct: 638 GITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTK 697
Query: 870 RPSMSQCSS 878
S C +
Sbjct: 698 TLSFKPCGA 706
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 167 bits (424), Expect = 4e-41
Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)
Query: 505 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 564
S + R R +G FN P+KG+Q+L+E + +TP +A FL + +GL++ IG++L
Sbjct: 56 SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
Query: 565 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 624
G R+ + N VL VD +F+ + L +ALR+F R+ GEAQK++R++EAF+QRYC+C
Sbjct: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
Query: 625 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 684
NPGV F++ DT ++L+FA+I+LNT +++PNV+ K LE F+ RG+++G D+P E
Sbjct: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
Query: 685 MLMGIYERIRKRELKTNED 703
+L +Y+ IR K ED
Sbjct: 230 LLRNLYDSIRNEPFKIPED 248
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 167 bits (424), Expect = 4e-41
Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)
Query: 505 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 564
S + R R +G FN P+KG+Q+L+E + +TP +A FL + +GL++ IG++L
Sbjct: 56 SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
Query: 565 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 624
G R+ + N VL VD +F+ + L +ALR+F R+ GEAQK++R++EAF+QRYC+C
Sbjct: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
Query: 625 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 684
NPGV F++ DT ++L+FA+I+LNT +++PNV+ K LE F+ RG+++G D+P E
Sbjct: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
Query: 685 MLMGIYERIRKRELKTNED 703
+L +Y+ IR K ED
Sbjct: 230 LLRNLYDSIRNEPFKIPED 248
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 161 bits (408), Expect = 3e-39
Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
R + +G FN P+KG+Q+LIE + +T +A FL + +GL++ IG++LG R
Sbjct: 62 RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
+FN VL V+ +F+ + L +ALR+F R+ GEAQK++R++EAF+QRYC CN GV
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
F++ DT ++L+FAII+LNT +++PNVK K +E FI RG++DG D+P E+L +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
Query: 690 YERIRKRELKTNED 703
YE I+ K ED
Sbjct: 236 YESIKNEPFKIPED 249
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 161 bits (408), Expect = 3e-39
Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
R + +G FN P+KG+Q+LIE + +T +A FL + +GL++ IG++LG R
Sbjct: 62 RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
+FN VL V+ +F+ + L +ALR+F R+ GEAQK++R++EAF+QRYC CN GV
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
F++ DT ++L+FAII+LNT +++PNVK K +E FI RG++DG D+P E+L +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
Query: 690 YERIRKRELKTNED 703
YE I+ K ED
Sbjct: 236 YESIKNEPFKIPED 249
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 161 bits (407), Expect = 4e-39
Identities = 82/194 (42%), Positives = 127/194 (65%), Gaps = 6/194 (3%)
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
R + +G FN P+KG+Q+LIE + +P VA FL + +GL++ +IG++LG R
Sbjct: 66 RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
+FN VL V+ +F+ + L +ALR+F R+ GEAQK++R++EAF+ RYC+CNPGV
Sbjct: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
F++ DT ++L+FAII+LNT +++ NV+ K E FI RG+++G D+P E+L +
Sbjct: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVRD--KPTAERFIAMNRGINEGGDLPEELLRNL 239
Query: 690 YERIRKRELKTNED 703
YE I+ K ED
Sbjct: 240 YESIKNEPFKIPED 253
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
Length = 1849
Score = 159 bits (403), Expect = 1e-38
Identities = 83/186 (44%), Positives = 120/186 (64%), Gaps = 4/186 (2%)
Query: 517 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 576
G++LFNKKP++G+QYL E+G + TP +A FL Q + L +GEFLG+ K FN++V+
Sbjct: 705 GIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVM 763
Query: 577 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 636
VD+ DFS + ALR F R+ GEAQK++RL+E F+ RY CN G F + D
Sbjct: 764 YAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASAD 822
Query: 637 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 696
T ++LA++II+L TD++SP VK KM E +IK RG++D +D+P E L IY I +
Sbjct: 823 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGK 880
Query: 697 ELKTNE 702
++ E
Sbjct: 881 KISMKE 886
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 152 bits (385), Expect = 1e-36
Identities = 79/186 (42%), Positives = 119/186 (63%), Gaps = 4/186 (2%)
Query: 517 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 576
G+ LFNKKP++G+Q+L E+G + + +A FL Q + L +G+FLG+ + FN++V+
Sbjct: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
Query: 577 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 636
VD++DF E ALR F R+ GEAQK++RL+E F+ RY CN G F + D
Sbjct: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
Query: 637 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 696
T ++LA++II+L TD++SP VK KM E +IK RG++D +D+P E L IYE I +
Sbjct: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
Query: 697 ELKTNE 702
++ E
Sbjct: 826 KIAMKE 831
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 146 bits (369), Expect = 9e-35
Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
+++ IG FN P KG+QY IE + +A FL + +GL++ IG +LG R
Sbjct: 61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
Query: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
N VL VD +F+ + L +ALR+F R+ GEAQK++R++EAF+ RYC+CNPGV
Sbjct: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178
Query: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
F++ DT ++L+F+II+LNT +++PNV+ + E F+ RG+++G D+P + L +
Sbjct: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234
Query: 690 YERIRKRELKTNED 703
++ I+ ED
Sbjct: 235 FDSIKSEPFSIPED 248
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 137 bits (344), Expect = 7e-32
Identities = 78/204 (38%), Positives = 122/204 (59%), Gaps = 9/204 (4%)
Query: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGF--VPDTPVGVAHFLLQRKGLSRQMIGEFLGNR 567
+K+ G FN+KP+KG+Q+L E+G +P VA +L + L ++MIGEF+ +R
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDR 758
Query: 568 QKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPG 627
+ N D+L+ V F + LDEALR + R+ GEA ++RL+EAF++R+ CN
Sbjct: 759 K---NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGS 815
Query: 628 VVRQFRNPDTIFILAFAIILLNTDMYSPNV-KPERKMKLEDFIKNLRGVDDGEDIPREML 686
F N D F LA+A+I+LNTD ++ NV K M LE+F KNL+GV+ G+D +++L
Sbjct: 816 ---PFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDIL 872
Query: 687 MGIYERIRKRELKTNEDHVSQVQK 710
+Y I+ E+ E+ V++
Sbjct: 873 EDMYHAIKNEEIVMPEEQTGLVRE 896
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 106 bits (265), Expect = 1e-22
Identities = 74/229 (32%), Positives = 121/229 (52%), Gaps = 17/229 (7%)
Query: 470 NCSSESSSRDSLREQTLSKQTY-HKEARNSWDSPAFSNDVIRKRHYRI--GLNLFNKKPE 526
+C + + D L Q L K T+ H N FS RK + ++ G FN P+
Sbjct: 95 SCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFS---FRKLYMQLDEGSLTFNANPD 151
Query: 527 KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS 586
+GV Y + +G + D+P +A F+ + L+ + + +L R RDVLD +V +F
Sbjct: 152 EGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER-----RDVLDDLVTLHNFR 206
Query: 587 TMELDEALRKFQAHIRVQGE-AQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFA 644
L ALR+F HI E + +E LI FS R+C CNP ++R+ +PD +++L ++
Sbjct: 207 NQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYS 266
Query: 645 IILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERI 693
+ILL+ D+ SP+VK KM +FI+N R ++I + + +Y+ I
Sbjct: 267 LILLSIDLTSPHVK--NKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 93.2 bits (230), Expect = 1e-18
Identities = 54/170 (31%), Positives = 95/170 (55%), Gaps = 8/170 (4%)
Query: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
+A L + +G + + +L + F+R V + + F LD ALR F + +
Sbjct: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
Query: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
GE Q+ ER++ FS+R+ CNPG+ F + D++ L AI+LLNTD++ N+ + M
Sbjct: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704
Query: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK--TNEDHVSQVQKVE 712
++FI NL G+ DG + P+E+L +Y IR +L+ +E+ ++ +K +
Sbjct: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQ 754
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 89.7 bits (221), Expect = 1e-17
Identities = 60/182 (32%), Positives = 96/182 (52%), Gaps = 10/182 (5%)
Query: 546 AHFLLQR----KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHI 601
AH L +R +G R + LG + +F+R V + DFS + LD ALR F
Sbjct: 314 AHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAF 372
Query: 602 RVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPER 661
+ GE Q+ ER++ FS+RYC CNP + D I L A++LLNTD++ N+ +
Sbjct: 373 PLMGETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GK 427
Query: 662 KMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPI 721
KM + FI NL ++DG+D +++L +Y I+ +L+ D + + +L+ K
Sbjct: 428 KMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGT 487
Query: 722 GS 723
G+
Sbjct: 488 GT 489
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 89.4 bits (220), Expect = 2e-17
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)
Query: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
+A L Q R + + LG + +F++ V + + DF+ M LD++LR F +
Sbjct: 54 LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112
Query: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
GE Q+ ER++ FS RY CNP + + D + L AI+LLNTD++ N+ +KM
Sbjct: 113 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167
Query: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 720
++FI NL+GV++G D +++L +Y I+ +L+ E S + E+ G P
Sbjct: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 227
Query: 721 --IGSLHPGLGCVLSLPH 736
I + L +PH
Sbjct: 228 KTISRIGSTTNPFLDIPH 245
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 89.4 bits (220), Expect = 2e-17
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)
Query: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
+A L Q R + + LG + +F++ V + + DF+ M LD++LR F +
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646
Query: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
GE Q+ ER++ FS RY CNP + + D + L AI+LLNTD++ N+ +KM
Sbjct: 647 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701
Query: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 720
++FI NL+GV++G D +++L +Y I+ +L+ E S + E+ G P
Sbjct: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 761
Query: 721 --IGSLHPGLGCVLSLPH 736
I + L +PH
Sbjct: 762 KTISRIGSTTNPFLDIPH 779
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 88.6 bits (218), Expect = 3e-17
Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 6/155 (3%)
Query: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
+A L + G + + LG + F++ V + F+ M LD+ALR F + +
Sbjct: 561 LAKRLYRLDGFRKADVARHLG-KNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALM 619
Query: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
GE Q+ ER++ FSQRY CNP + D L A++LLNTD++ N+ ++M
Sbjct: 620 GETQERERVLAHFSQRYFQCNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMT 674
Query: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK 699
DFI NL G++DG D PRE+L +Y I+ +L+
Sbjct: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ 709
>gi|4504489 histidine-rich glycoprotein precursor [Homo sapiens]
Length = 525
Score = 76.3 bits (186), Expect = 2e-13
Identities = 56/185 (30%), Positives = 72/185 (38%), Gaps = 42/185 (22%)
Query: 935 EGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPP-----QAHLPSA 989
E S + P + + P +PH+ G PPP +H P
Sbjct: 269 ERSSTTKPPFKPHGSRDHHHPHKPHE----------------HGPPPPPDERDHSHGPPL 312
Query: 990 PALPPPHPPVVLPHLQHSVAGHHLGPPEGLPQAAMHGH-HTQYCHMQNPPPYHHHHHHHP 1048
P PPP P+ QH+ G + + H H + H Q+P HH H HHP
Sbjct: 313 PQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQHPHG-HHPHAHHP 371
Query: 1049 PQHI---QHAHQYH---HGPHGGHPAYGAHAHGHPPL------------PSAHVGHTVHH 1090
+H QH H +H H PHG HP +G H HGH P P + GH H
Sbjct: 372 HEHDTHRQHPHGHHPHGHHPHGHHP-HGHHPHGHHPHCHDFQDYGPCDPPPHNQGHCCHG 430
Query: 1091 HGQPP 1095
HG PP
Sbjct: 431 HGPPP 435
Score = 33.1 bits (74), Expect = 1.5
Identities = 21/76 (27%), Positives = 27/76 (35%), Gaps = 17/76 (22%)
Query: 1039 PYHHHHHHHPPQHIQHAHQYHHGPHGGHPA-------YGAHAHGHPPLPSAHVGHTVHHH 1091
P H + + P H+ H +H G H +G+ H HP H H H
Sbjct: 246 PQEHENINGVPPHL--GHPFHWGGHERSSTTKPPFKPHGSRDHHHP--------HKPHEH 295
Query: 1092 GQPPAPPPPTSSKAKP 1107
G PP P S P
Sbjct: 296 GPPPPPDERDHSHGPP 311
>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
Length = 424
Score = 65.5 bits (158), Expect = 3e-10
Identities = 55/162 (33%), Positives = 63/162 (38%), Gaps = 32/162 (19%)
Query: 957 RPHQTM------PNSSSLLGSLFGS---KRGKPPPQAHLPSAP---ALPPPHPPVVLPHL 1004
RPHQ P++ + + S GS G PPP + P P ALPP PP + P
Sbjct: 206 RPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPP 265
Query: 1005 QHSVAGHHLGPPEGLPQAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHIQH-----AHQYH 1059
A H P G P A GH H H H PP + H H
Sbjct: 266 MPPGAAGHGPPSAGTPGAGHPGHG------------HSHPHPFPPGGMPHPGMSQMQLAH 313
Query: 1060 HGPHG-GHPAYGAHAHGHPPLPSAHVGHTVHHHGQPPAPPPP 1100
HGPHG GHP G G P P G + H G PP PP
Sbjct: 314 HGPHGLGHPHAGPPGSGGQPPPRPPPG--MPHPGPPPMGMPP 353
>gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 60.5 bits (145), Expect = 9e-09
Identities = 60/210 (28%), Positives = 71/210 (33%), Gaps = 59/210 (28%)
Query: 960 QTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLP----------HLQHSVA 1009
QT+P G S+ P H +A +PPP PP P H QHSVA
Sbjct: 1597 QTVPGHHVTPGHFLPSQN---PTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVA 1653
Query: 1010 --------------------GHHLGPPEGLPQAAMHGH------------HTQYCHMQN- 1036
GHHL PP P A H H Q+ H+ N
Sbjct: 1654 HVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNS 1713
Query: 1037 ----PPPYHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGH-PPLPSAHVGHTVHHH 1091
PPP H A HH PH G P + + AH PP PS HT
Sbjct: 1714 APPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGP 1773
Query: 1092 GQ--------PPAPPPPTSSKAKPSGISTI 1113
G P P P T +P G ++I
Sbjct: 1774 GPQHQPSGTGPHCPLPVTGPHLQPQGPNSI 1803
Score = 48.9 bits (115), Expect = 3e-05
Identities = 51/188 (27%), Positives = 60/188 (31%), Gaps = 47/188 (25%)
Query: 957 RPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPP 1016
+P N + L GSL P LP + Q +V GHH+ P
Sbjct: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTS-------------QQTVPGHHVTPG 1607
Query: 1017 EGLPQAAMHGHHTQYCHMQNPPP-----YHHHHHHHPPQHIQHAHQYHHGP-HGGHPAYG 1070
LP HH + PPP H P H QH+ + GP H P G
Sbjct: 1608 HFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTP--G 1665
Query: 1071 AHAHG-----HPPLPSAHVGHTVHHH---------------------GQPPAPPPPTSSK 1104
+H H H P P G HHH PP PPPP S
Sbjct: 1666 SHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
Query: 1105 AKPSGIST 1112
SG T
Sbjct: 1726 VLASGHHT 1733
Score = 35.4 bits (80), Expect = 0.30
Identities = 37/149 (24%), Positives = 51/149 (34%), Gaps = 13/149 (8%)
Query: 958 PHQTMPNSSSLLGSLFGSKRGKP--PPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGP 1015
P + NSS L S K PP HL + P PH PV +L LG
Sbjct: 1417 PQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGS 1476
Query: 1016 PEGLPQAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHI-QHAHQYHHGPHGGHPAYGAHAH 1074
P HH+Q + P + + Q++ + Q G G +
Sbjct: 1477 P-------YRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSA 1529
Query: 1075 GHPPLPSAHVGHTVHHHGQPPAPPPPTSS 1103
+ + T PP PPPP+SS
Sbjct: 1530 TYSQFNQQSLNSTA---PPPPPPPPPSSS 1555
>gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 60.5 bits (145), Expect = 9e-09
Identities = 60/210 (28%), Positives = 71/210 (33%), Gaps = 59/210 (28%)
Query: 960 QTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLP----------HLQHSVA 1009
QT+P G S+ P H +A +PPP PP P H QHSVA
Sbjct: 1597 QTVPGHHVTPGHFLPSQN---PTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVA 1653
Query: 1010 --------------------GHHLGPPEGLPQAAMHGH------------HTQYCHMQN- 1036
GHHL PP P A H H Q+ H+ N
Sbjct: 1654 HVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNS 1713
Query: 1037 ----PPPYHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGH-PPLPSAHVGHTVHHH 1091
PPP H A HH PH G P + + AH PP PS HT
Sbjct: 1714 APPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGP 1773
Query: 1092 GQ--------PPAPPPPTSSKAKPSGISTI 1113
G P P P T +P G ++I
Sbjct: 1774 GPQHQPSGTGPHCPLPVTGPHLQPQGPNSI 1803
Score = 48.9 bits (115), Expect = 3e-05
Identities = 51/188 (27%), Positives = 60/188 (31%), Gaps = 47/188 (25%)
Query: 957 RPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPP 1016
+P N + L GSL P LP + Q +V GHH+ P
Sbjct: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTS-------------QQTVPGHHVTPG 1607
Query: 1017 EGLPQAAMHGHHTQYCHMQNPPP-----YHHHHHHHPPQHIQHAHQYHHGP-HGGHPAYG 1070
LP HH + PPP H P H QH+ + GP H P G
Sbjct: 1608 HFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTP--G 1665
Query: 1071 AHAHG-----HPPLPSAHVGHTVHHH---------------------GQPPAPPPPTSSK 1104
+H H H P P G HHH PP PPPP S
Sbjct: 1666 SHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
Query: 1105 AKPSGIST 1112
SG T
Sbjct: 1726 VLASGHHT 1733
Score = 35.4 bits (80), Expect = 0.30
Identities = 37/149 (24%), Positives = 51/149 (34%), Gaps = 13/149 (8%)
Query: 958 PHQTMPNSSSLLGSLFGSKRGKP--PPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGP 1015
P + NSS L S K PP HL + P PH PV +L LG
Sbjct: 1417 PQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGS 1476
Query: 1016 PEGLPQAAMHGHHTQYCHMQNPPPYHHHHHHHPPQHI-QHAHQYHHGPHGGHPAYGAHAH 1074
P HH+Q + P + + Q++ + Q G G +
Sbjct: 1477 P-------YRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSA 1529
Query: 1075 GHPPLPSAHVGHTVHHHGQPPAPPPPTSS 1103
+ + T PP PPPP+SS
Sbjct: 1530 TYSQFNQQSLNSTA---PPPPPPPPPSSS 1555
>gi|24497504 forkhead box A2 isoform 2 [Homo sapiens]
Length = 457
Score = 57.8 bits (138), Expect = 6e-08
Identities = 51/178 (28%), Positives = 71/178 (39%), Gaps = 27/178 (15%)
Query: 911 SLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLG 970
+L++ + A G++++AG+ S + + P A+ T PH +
Sbjct: 262 ALKEAAGAAGSGKKAAAGAQASQAQLGEAAGP-----ASETPAGTESPHSSASPCQEHKR 316
Query: 971 SLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPE--GLPQAA--MHG 1026
G +G P A AL PP P P Q A H LGPP GLP A
Sbjct: 317 GGLGELKGTP--------AAALSPPEP-APSPGQQQQAAAHLLGPPHHPGLPPEAHLKPE 367
Query: 1027 HHTQYCH-------MQNPPPYHHHHHHHPP--QHIQHAHQYHHGPHGGHPAYGAHAHG 1075
HH + H M + +HH HHHH P ++ Q H P G P G+ A G
Sbjct: 368 HHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMG 425
>gi|194394143 forkhead box A2 isoform 1 [Homo sapiens]
Length = 463
Score = 57.8 bits (138), Expect = 6e-08
Identities = 51/178 (28%), Positives = 71/178 (39%), Gaps = 27/178 (15%)
Query: 911 SLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLG 970
+L++ + A G++++AG+ S + + P A+ T PH +
Sbjct: 268 ALKEAAGAAGSGKKAAAGAQASQAQLGEAAGP-----ASETPAGTESPHSSASPCQEHKR 322
Query: 971 SLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPE--GLPQAA--MHG 1026
G +G P A AL PP P P Q A H LGPP GLP A
Sbjct: 323 GGLGELKGTP--------AAALSPPEP-APSPGQQQQAAAHLLGPPHHPGLPPEAHLKPE 373
Query: 1027 HHTQYCH-------MQNPPPYHHHHHHHPP--QHIQHAHQYHHGPHGGHPAYGAHAHG 1075
HH + H M + +HH HHHH P ++ Q H P G P G+ A G
Sbjct: 374 HHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMG 431
>gi|23308699 transcription factor MAFB [Homo sapiens]
Length = 323
Score = 56.6 bits (135), Expect = 1e-07
Identities = 48/176 (27%), Positives = 70/176 (39%), Gaps = 37/176 (21%)
Query: 944 MRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPH 1003
+++ E P RP + + S+ + + P + +PS+P+ P L
Sbjct: 31 VKKEPLGRAERPGRPCTRLQPAGSVSSTPLST------PCSSVPSSPSFSPTEQKTHLED 84
Query: 1004 LQHSVAGHHLGPPEGL---PQAAMH---GHHTQYCHMQNPPPY---HHHHHHHPPQHIQH 1054
L + + PE L P+ A+ G H +Q+ + HHHHHHH H
Sbjct: 85 LYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDSFRGAHHHHHHH------H 138
Query: 1055 AHQYHHGPHGG--HPAYGAHAHGHPPLPSAHVGHTVHHHGQPPAPPPPTSSKAKPS 1108
H +H P G H G HAH H HHH +PPP SS A P+
Sbjct: 139 PHPHHAYPGAGVAHDELGPHAHPH------------HHHHHQASPPP--SSAASPA 180
>gi|59938776 cAMP responsive element binding protein 5 isoform delta
[Homo sapiens]
Length = 369
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/203 (27%), Positives = 79/203 (38%), Gaps = 43/203 (21%)
Query: 934 VEGSIISSPHM--RRRATSTRECPSR-PHQTMPNSSSLLG------SLFGSKRGKPPPQA 984
V GS+ S H+ R+R P P+ TMP SS++L S+ S G P
Sbjct: 18 VPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNL 77
Query: 985 HLPSA-PALPPPHP-------------PVVLPHLQHSVAGHHL----GPPEGLPQAAMHG 1026
P A P + P H P + + + GH + + P MH
Sbjct: 78 SNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHS 137
Query: 1027 HHTQYCHMQNPPPYHHH-HHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLPSAHVG 1085
H Q+ Q PP+H + H H P H H +H H H ++ +H H HP
Sbjct: 138 HPHQH---QTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSH-SHLHAHPA------- 186
Query: 1086 HTVHHHGQPPAPPPPTSSKAKPS 1108
HH P PP T ++A+ S
Sbjct: 187 ----HHQTSPHPPLHTGNQAQVS 205
>gi|59938774 cAMP responsive element binding protein 5 isoform beta
[Homo sapiens]
Length = 501
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/203 (27%), Positives = 79/203 (38%), Gaps = 43/203 (21%)
Query: 934 VEGSIISSPHM--RRRATSTRECPSR-PHQTMPNSSSLLG------SLFGSKRGKPPPQA 984
V GS+ S H+ R+R P P+ TMP SS++L S+ S G P
Sbjct: 150 VPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNL 209
Query: 985 HLPSA-PALPPPHP-------------PVVLPHLQHSVAGHHL----GPPEGLPQAAMHG 1026
P A P + P H P + + + GH + + P MH
Sbjct: 210 SNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHS 269
Query: 1027 HHTQYCHMQNPPPYHHH-HHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLPSAHVG 1085
H Q+ Q PP+H + H H P H H +H H H ++ +H H HP
Sbjct: 270 HPHQH---QTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSH-SHLHAHPA------- 318
Query: 1086 HTVHHHGQPPAPPPPTSSKAKPS 1108
HH P PP T ++A+ S
Sbjct: 319 ----HHQTSPHPPLHTGNQAQVS 337
>gi|59938772 cAMP responsive element binding protein 5 isoform gamma
[Homo sapiens]
Length = 475
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/203 (27%), Positives = 79/203 (38%), Gaps = 43/203 (21%)
Query: 934 VEGSIISSPHM--RRRATSTRECPSR-PHQTMPNSSSLLG------SLFGSKRGKPPPQA 984
V GS+ S H+ R+R P P+ TMP SS++L S+ S G P
Sbjct: 124 VPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNL 183
Query: 985 HLPSA-PALPPPHP-------------PVVLPHLQHSVAGHHL----GPPEGLPQAAMHG 1026
P A P + P H P + + + GH + + P MH
Sbjct: 184 SNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHS 243
Query: 1027 HHTQYCHMQNPPPYHHH-HHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLPSAHVG 1085
H Q+ Q PP+H + H H P H H +H H H ++ +H H HP
Sbjct: 244 HPHQH---QTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSH-SHLHAHPA------- 292
Query: 1086 HTVHHHGQPPAPPPPTSSKAKPS 1108
HH P PP T ++A+ S
Sbjct: 293 ----HHQTSPHPPLHTGNQAQVS 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,673,183
Number of Sequences: 37866
Number of extensions: 2854508
Number of successful extensions: 19531
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 529
Number of HSP's that attempted gapping in prelim test: 13925
Number of HSP's gapped (non-prelim): 3584
length of query: 1114
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1001
effective length of database: 13,968,660
effective search space: 13982628660
effective search space used: 13982628660
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.