Search of human proteins with 19718766

Search of human proteins with 19718766

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo
sapiens]
         (875 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]    1759   0.0  
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]    1736   0.0  
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]    1710   0.0  
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        346   5e-95
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            301   1e-81
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            298   1e-80
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       279   9e-75
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     230   4e-60
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      226   7e-59
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   213   8e-55
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   213   8e-55
gi|222352183 neural precursor cell expressed, developmentally do...   204   3e-52
gi|21361472 neural precursor cell expressed, developmentally dow...   204   3e-52
gi|222352094 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352092 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352090 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352088 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352086 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352084 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352082 neural precursor cell expressed, developmentally do...   204   3e-52
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      204   4e-52
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   201   2e-51
gi|114520609 neural precursor cell expressed, developmentally do...   201   2e-51
gi|114520607 neural precursor cell expressed, developmentally do...   201   2e-51
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   201   2e-51
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   197   3e-50
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   197   3e-50
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              197   4e-50
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   193   7e-49
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   192   1e-48

>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score = 1759 bits (4557), Expect = 0.0
 Identities = 875/875 (100%), Positives = 875/875 (100%)

Query: 1   MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTF 60
           MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTF
Sbjct: 1   MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTF 60

Query: 61  LRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARI 120
           LRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARI
Sbjct: 61  LRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARI 120

Query: 121 DFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKS 180
           DFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKS
Sbjct: 121 DFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKS 180

Query: 181 LQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIR 240
           LQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIR
Sbjct: 181 LQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIR 240

Query: 241 RVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPE 300
           RVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPE
Sbjct: 241 RVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPE 300

Query: 301 YLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRN 360
           YLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRN
Sbjct: 301 YLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRN 360

Query: 361 LVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNK 420
           LVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNK
Sbjct: 361 LVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNK 420

Query: 421 KGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC 480
           KGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC
Sbjct: 421 KGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC 480

Query: 481 PFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRL 540
           PFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRL
Sbjct: 481 PFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRL 540

Query: 541 EMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFW 600
           EMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFW
Sbjct: 541 EMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFW 600

Query: 601 FNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQ 660
           FNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQ
Sbjct: 601 FNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQ 660

Query: 661 SLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDY 720
           SLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDY
Sbjct: 661 SLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDY 720

Query: 721 ILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGY 780
           ILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGY
Sbjct: 721 ILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGY 780

Query: 781 TRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTS 840
           TRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTS
Sbjct: 781 TRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTS 840

Query: 841 HTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 875
           HTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
Sbjct: 841 HTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 875


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score = 1736 bits (4495), Expect = 0.0
 Identities = 865/866 (99%), Positives = 866/866 (100%)

Query: 10  KSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA 69
           +SGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA
Sbjct: 7   RSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA 66

Query: 70  IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT 129
           IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT
Sbjct: 67  IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT 126

Query: 130 EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD 189
           EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD
Sbjct: 127 EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD 186

Query: 190 EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN 249
           EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN
Sbjct: 187 EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN 246

Query: 250 EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF 309
           EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF
Sbjct: 247 EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF 306

Query: 310 CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV 369
           CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV
Sbjct: 307 CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV 366

Query: 370 AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE 429
           AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE
Sbjct: 367 AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE 426

Query: 430 TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK 489
           TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK
Sbjct: 427 TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK 486

Query: 490 NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA 549
           NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA
Sbjct: 487 NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA 546

Query: 550 DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE 609
           DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE
Sbjct: 547 DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE 606

Query: 610 GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE 669
           GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE
Sbjct: 607 GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE 666

Query: 670 GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ 729
           GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ
Sbjct: 667 GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ 726

Query: 730 FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE 789
           FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE
Sbjct: 727 FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE 786

Query: 790 FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL 849
           FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL
Sbjct: 787 FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL 846

Query: 850 PEYSSKEKLKERLLKAITYAKGFGML 875
           PEYSSKEKLKERLLKAITYAKGFGML
Sbjct: 847 PEYSSKEKLKERLLKAITYAKGFGML 872


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score = 1710 bits (4428), Expect = 0.0
 Identities = 852/852 (100%), Positives = 852/852 (100%)

Query: 24  MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 83
           MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC
Sbjct: 1   MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60

Query: 84  DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 143
           DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER
Sbjct: 61  DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120

Query: 144 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 203
           EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM
Sbjct: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180

Query: 204 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 263
           EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL
Sbjct: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240

Query: 264 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 323
           SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK
Sbjct: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300

Query: 324 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 383
           LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV
Sbjct: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360

Query: 384 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 443
           VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL
Sbjct: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420

Query: 444 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 503
           IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS
Sbjct: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480

Query: 504 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 563
           ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ
Sbjct: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540

Query: 564 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 623
           GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI
Sbjct: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600

Query: 624 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 683
           YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS
Sbjct: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660

Query: 684 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 743
           QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE
Sbjct: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720

Query: 744 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 803
           SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR
Sbjct: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780

Query: 804 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 863
           LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
Sbjct: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840

Query: 864 KAITYAKGFGML 875
           KAITYAKGFGML
Sbjct: 841 KAITYAKGFGML 852


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  346 bits (888), Expect = 5e-95
 Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)

Query: 442 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 501
           PLIP+ +F N  L+ +  M++ +T+      ++FSF   PF+++   K + +  D+  +M
Sbjct: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392

Query: 502 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 558
            +  R +++  + + Q+ +    +L +KVRR H++ D+L  L        ADLKK+L V 
Sbjct: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448

Query: 559 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 618
           F GE G+D GG++KE+F L++ +IF+PD GMFTY + +   WF+    +   +F L+GI+
Sbjct: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508

Query: 619 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 664
           +GLA+YN+  LD+ FP   Y+KL+                  T  DL    P L   L +
Sbjct: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568

Query: 665 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 724
           LL +EGNVE+D   TFQ+ Q + FG    Y+LK  GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627

Query: 725 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 784
           S+ KQF AF  GFH V   + L  L RPEE+E+L+CGS +LD  AL+ +T+YD GY +  
Sbjct: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685

Query: 785 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 844
           + I+ FW++V  F  + ++  L FTTG+DR PVGG+  L   I+KN   T  LP +HTCF
Sbjct: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745

Query: 845 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
           N L LP Y SK+ LK++L+  I+ ++GFG+
Sbjct: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  301 bits (772), Expect = 1e-81
 Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)

Query: 443  LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 496
            +I +++F    + E++++  DY        + +  +   +  T PF+ +A  K   L  D
Sbjct: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669

Query: 497  NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 551
              ++M      + R+      L   + +NP L L VRR++I+ DA+   E++      D 
Sbjct: 670  AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726

Query: 552  KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 611
            KK L V F GE  VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    
Sbjct: 727  KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786

Query: 612  FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 670
            F LIG++ GLAIYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E 
Sbjct: 787  FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846

Query: 671  NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 730
            ++E+   + F I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F
Sbjct: 847  DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905

Query: 731  KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 790
             AF  GFH V     L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ F
Sbjct: 906  DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964

Query: 791  WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 850
            WE+ H    E+K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP
Sbjct: 965  WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024

Query: 851  EYSSKEKLKERLLKAITYAKGFGML 875
            +Y+ KE L+ +L++AI + +GF ++
Sbjct: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  298 bits (763), Expect = 1e-80
 Identities = 167/434 (38%), Positives = 255/434 (58%), Gaps = 12/434 (2%)

Query: 448  EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMY----- 502
            ++IN    +   MD ++   ++  +   +  T PF+ +A  K   L  D  ++M      
Sbjct: 630  DYINWVQQQAYGMDVNHGLTEL-ADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQ 688

Query: 503  SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGE 562
            + R+      L   + +NP L L VRR++I+ DA+   E++      D KK L V F GE
Sbjct: 689  AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDYKKPLKVIFVGE 745

Query: 563  QGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLA 622
              VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    F LIG++ GLA
Sbjct: 746  DAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLA 805

Query: 623  IYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQ 681
            IYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E ++E+   + F 
Sbjct: 806  IYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFT 865

Query: 682  ISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVT 741
            I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F AF  GFH V 
Sbjct: 866  IT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVC 924

Query: 742  NESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQ 801
                L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ FWE+ H    E+
Sbjct: 925  GGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEK 983

Query: 802  KRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
            K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP+Y+ KE L+ +
Sbjct: 984  KKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSK 1043

Query: 862  LLKAITYAKGFGML 875
            L++AI + +GF ++
Sbjct: 1044 LIQAIDHNEGFSLI 1057


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  279 bits (713), Expect = 9e-75
 Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)

Query: 444  IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 493
            + ++ F    ++ ++++ +DY  + +            ++  +  + PFI +A  K   L
Sbjct: 607  VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666

Query: 494  YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 547
              D  ++M       + + + +L +L      +P+L L VRR++++ DAL  L   ++ +
Sbjct: 667  QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723

Query: 548  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 607
              DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP  GMFTY + + L WF+ + F 
Sbjct: 724  DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783

Query: 608  TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 667
                F LIGI  GLAIYN+ ++D+HFP+ +Y+KL+  K    DL +  P   +SL++LL+
Sbjct: 784  EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843

Query: 668  YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726
            Y G +VE+   + F I + + +G      L   GD + +  +NR+EFV+ Y +Y+   SV
Sbjct: 844  YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902

Query: 727  EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 786
             + + AF  GF  V     L+ LF+P E+  ++ G+ N +++ LEET  Y G Y+     
Sbjct: 903  HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961

Query: 787  IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 846
            ++ FWE  H F  E+K+ FL F TG+DR P+ G+  L+++I       E LP +HTC+N+
Sbjct: 962  VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021

Query: 847  LLLPEYSSKEKLKERLLKAITYAKGFGM 874
            L LP+YSSKE L  RL +A+   +GF +
Sbjct: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  230 bits (587), Expect = 4e-60
 Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)

Query: 434  VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 485
            V  + C+ P  +   +E ++  LN  +E+ + Y  +K+  +   +   C      PFI N
Sbjct: 580  VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637

Query: 486  AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 539
             ++K   L+ D  +++ S++    L S    ++      L P   L VRR+H+I+D L +
Sbjct: 638  NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697

Query: 540  LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 599
            L     E   DL+K+L+V F GE G D GGV KEFF  +  E+  P+ GMF Y E     
Sbjct: 698  LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754

Query: 600  WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 659
            WF       + ++   G++ GL+++N  + ++ FP+ +++KL+ +  +  DL +  P L 
Sbjct: 755  WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814

Query: 660  QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 716
            ++L+ LL+ EG N E+   I F +   + D        +L  NG  I +   N++++V+ 
Sbjct: 815  KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867

Query: 717  YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 776
            Y +YI N SV+  ++ FRRGF+ + +E  +K LF PEE++ +I G+ + D++  E+   Y
Sbjct: 868  YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926

Query: 777  DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 836
            + GY      I  FW+  H  T E+K+ FL F TGTDR  +  L  +K+         ER
Sbjct: 927  EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986

Query: 837  LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 873
             P  + TCF+VL LP+YS+ E ++E L +AI   +GFG
Sbjct: 987  DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  226 bits (576), Expect = 7e-59
 Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)

Query: 434  VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 488
            V   +CR P   F        +N  ++   ++ +D      ET +   F   PFI N+++
Sbjct: 572  VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631

Query: 489  KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 542
            K   L  D+ I+M  SE++  +L   +++Q +     +P   L+VRR  ++ DAL +L  
Sbjct: 632  KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689

Query: 543  IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 602
             +     D  K L VEF  E   + GGVS EFF  + EE+  P+ GMF Y E     WF 
Sbjct: 690  -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748

Query: 603  PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 662
                  + ++ L G++ GL+++N  + ++ FP+ +Y+KL+ +K +  DL +  P L +SL
Sbjct: 749  AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808

Query: 663  KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 719
            +++L +   ++ D + I F I   Q D+       DL  NG  IP+   N++++V+ Y D
Sbjct: 809  QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861

Query: 720  YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 779
            YI N SV+  ++ F+RGF+ V  +  L++ F PEE+   I G+ + D++  E+ ++Y+ G
Sbjct: 862  YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920

Query: 780  YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 838
            Y +    I+ FW+  H  T ++K+ FL F TG DR    G+ K++++       +ER  P
Sbjct: 921  YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980

Query: 839  TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
            TS TC N+L LP+YS+ E+++E L  AI   +GF
Sbjct: 981  TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  213 bits (541), Expect = 8e-55
 Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)

Query: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
           L     L  ++++ V R  + +D+    + I    P DL+++LY+   GE+G+D GG+++
Sbjct: 66  LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122

Query: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 628
           E+F L+  E+ NP   +F Y  ++      NP+S       T    IG  + +A+Y+   
Sbjct: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182

Query: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
           +D  F +  Y++++ K+ T +DL    P  Y S+  + E   N+E+  +  + I   ++ 
Sbjct: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240

Query: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
           G    ++LKE G+ I +T EN++E++ L +D+   + VE+Q KAF  GF+ V     L+Y
Sbjct: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300

Query: 749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 808
            F  +E+EL++CG + +D    +++T Y   YT++S  I+ FW++V    +E++   LQF
Sbjct: 301 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 358

Query: 809 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
            TGT R PVGG  +L       K  I K G +T  LP SHTCFN L LP Y S E+L+E+
Sbjct: 359 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 417

Query: 862 LLKAITYAKGFG 873
           LL AI   +GFG
Sbjct: 418 LLYAIEETEGFG 429


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
           isoform 1 [Homo sapiens]
          Length = 870

 Score =  213 bits (541), Expect = 8e-55
 Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)

Query: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
           L     L  ++++ V R  + +D+    + I    P DL+++LY+   GE+G+D GG+++
Sbjct: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561

Query: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 628
           E+F L+  E+ NP   +F Y  ++      NP+S       T    IG  + +A+Y+   
Sbjct: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621

Query: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
           +D  F +  Y++++ K+ T +DL    P  Y S+  + E   N+E+  +  + I   ++ 
Sbjct: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679

Query: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
           G    ++LKE G+ I +T EN++E++ L +D+   + VE+Q KAF  GF+ V     L+Y
Sbjct: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 739

Query: 749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 808
            F  +E+EL++CG + +D    +++T Y   YT++S  I+ FW++V    +E++   LQF
Sbjct: 740 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 797

Query: 809 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
            TGT R PVGG  +L       K  I K G +T  LP SHTCFN L LP Y S E+L+E+
Sbjct: 798 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 856

Query: 862 LLKAITYAKGFG 873
           LL AI   +GFG
Sbjct: 857 LLYAIEETEGFG 868


>gi|222352183 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 871 GF 872
           GF
Sbjct: 849 GF 850


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949

Query: 871 GF 872
           GF
Sbjct: 950 GF 951


>gi|222352094 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828

Query: 871 GF 872
           GF
Sbjct: 829 GF 830


>gi|222352092 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828

Query: 871 GF 872
           GF
Sbjct: 829 GF 830


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941

Query: 871 GF 872
           GF
Sbjct: 942 GF 943


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 612 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 669

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 670 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 729

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 730 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 785

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 786 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 844

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 845 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 904

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 905 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 961

Query: 871 GF 872
           GF
Sbjct: 962 GF 963


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 620 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 677

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 678 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 737

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 738 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 793

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 794 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 852

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 853 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 912

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 913 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 969

Query: 871 GF 872
           GF
Sbjct: 970 GF 971


>gi|222352084 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 871 GF 872
           GF
Sbjct: 849 GF 850


>gi|222352082 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 871 GF 872
           GF
Sbjct: 849 GF 850


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  204 bits (518), Expect = 4e-52
 Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)

Query: 523  LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 582
            + + VRRDH+ +D+   L     ++P ++K +LY+ FEGE+G D GG+ +E++ ++  E+
Sbjct: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073

Query: 583  FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 638
            FNP   +F      ++ +  NPSS         F  +G ++  A+Y+N +L+ +F    Y
Sbjct: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133

Query: 639  RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 697
            + ++GK   + D+       YQ L  LLE +   +  D+  + ++ +   FG   + DLK
Sbjct: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190

Query: 698  ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
             NG  I +T EN+KE+V+L     +  ++ KQ  AF  GF+ +  +  L  +F  +E+EL
Sbjct: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249

Query: 758  LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
            LI G   +D   L+  TEY   Y  +S+ I+ FW  + SF    +  FLQF TGT + P+
Sbjct: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308

Query: 818  GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 869
             G   L       K  I ++   T+RLP++HTCFN L LP Y S EKL+  LL AI   +
Sbjct: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368

Query: 870  KGFGM 874
            +GFG+
Sbjct: 4369 EGFGL 4373



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 16/50 (32%), Positives = 24/50 (48%)

Query: 171  KQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQG 220
            ++HT+EE  S   +DED  +DE+E+        +ED E       D   G
Sbjct: 2413 EEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDG 2462


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
           [Homo sapiens]
          Length = 922

 Score =  201 bits (512), Expect = 2e-51
 Identities = 127/372 (34%), Positives = 202/372 (54%), Gaps = 19/372 (5%)

Query: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
           L Q   L  ++++ V R  + +D+    + I    P DL+++LYV F GE+G+D GG+++
Sbjct: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613

Query: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 628
           E+F L+  E+ NP   +F Y  ++      NP+S    +    F  IG  + +A+++   
Sbjct: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673

Query: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
           +D  F +  Y++++ KK T +DL       Y SL  +   + N+E+  +  +     ++ 
Sbjct: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731

Query: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
           G    +DLK  G  I +T EN+ E++ L +++  ++ V++Q KAF  GF+ V     L+Y
Sbjct: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQY 791

Query: 749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 808
            F  +E+E+++CG + +D    +  T Y   YTR+S  I  FW+ V    +E +   LQF
Sbjct: 792 -FDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLLQF 849

Query: 809 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
            TGT R P+GG  +L       K  I K G DT  LP SHTCFN L LP Y S E+LKE+
Sbjct: 850 VTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEK 908

Query: 862 LLKAITYAKGFG 873
           LL AI   +GFG
Sbjct: 909 LLFAIEETEGFG 920


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  201 bits (512), Expect = 2e-51
 Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           +K+RR  +++D+  R+  + ++    LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602

Query: 585 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
           P  G+F Y  +       NP+S     +    F  IG V G+A+Y+  +LD  F    Y+
Sbjct: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662

Query: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
            ++ K  T  D+       Y SL+ +LE   N   ++ + F I + +LFG    ++LK  
Sbjct: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718

Query: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
           G +I +TN+N+KE++ L   +     ++KQ  AF+ GF  +  +  +K +F   E+ELL+
Sbjct: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777

Query: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
           CG  ++D     E T+Y  GY+ +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837

Query: 820 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
             +L      NGP +         E+LP +HTCFN L LP Y S E+L ++L  AI   +
Sbjct: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894

Query: 871 GF 872
           GF
Sbjct: 895 GF 896


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  201 bits (512), Expect = 2e-51
 Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)

Query: 525  LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
            +K+RR  +++D+  R+  + ++    LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 892  MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949

Query: 585  PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
            P  G+F Y  +       NP+S     +    F  IG V G+A+Y+  +LD  F    Y+
Sbjct: 950  PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009

Query: 640  KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
             ++ K  T  D+       Y SL+ +LE   N   ++ + F I + +LFG    ++LK  
Sbjct: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065

Query: 700  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
            G +I +TN+N+KE++ L   +     ++KQ  AF+ GF  +  +  +K +F   E+ELL+
Sbjct: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124

Query: 760  CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
            CG  ++D     E T+Y  GY+ +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184

Query: 820  LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
              +L      NGP +         E+LP +HTCFN L LP Y S E+L ++L  AI   +
Sbjct: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241

Query: 871  GF 872
            GF
Sbjct: 1242 GF 1243


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
           sapiens]
          Length = 862

 Score =  201 bits (511), Expect = 2e-51
 Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)

Query: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
           ++++ V R  + +D+    + I   +P DL+++L+V F GE+G+D GGV++E+F L+  E
Sbjct: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562

Query: 582 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 637
           + NP   +F Y  +       NP+S+        F  IG  + +A+++   +D  F +  
Sbjct: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622

Query: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 696
           Y++++ K    +DL    P  Y SL  +   E N+E+ D+ + F + + ++ G    +DL
Sbjct: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679

Query: 697 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 756
           K NG  I +T EN++E++ + +++ L++ VE+Q +AF  GF+ +  +  L+Y F  +E+E
Sbjct: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738

Query: 757 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 816
           +L+CG + +D    +    Y   Y R S  I  FW+ V    +E++   LQF TGT R P
Sbjct: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797

Query: 817 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 869
           VGG        G  K  I K G +   LP SHTCFN L LP Y S E+LKE+LL AI   
Sbjct: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856

Query: 870 KGFG 873
           +GFG
Sbjct: 857 EGFG 860


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
           sapiens]
          Length = 757

 Score =  197 bits (502), Expect = 3e-50
 Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)

Query: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
           + R++V R+ I +++      I    P DLKK+L V+F GE+G+D GGV++E+  L+  E
Sbjct: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454

Query: 582 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 637
           + NP  G+F Y  ++  +   NP S    +    F  +G ++GLA+++   ++  F +  
Sbjct: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514

Query: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 697
           Y++L+GK     DL    P L++SL  +LE   ++   +  TF +   + FG  + ++LK
Sbjct: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571

Query: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
            NG  +P+T EN+KE+V LY ++   + +E QF A ++GF+ +  +  LK  F  +E+EL
Sbjct: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630

Query: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
           +I G   +D    +  T        DS ++R FW+ V +F +E++   LQF TG+ R P+
Sbjct: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689

Query: 818 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 867
            G   L+      GP          +T+ LP +HTCFN + +P Y S EKL E+LL A+ 
Sbjct: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749

Query: 868 YAKGFGM 874
              GF +
Sbjct: 750 ETCGFAV 756


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
           sapiens]
          Length = 731

 Score =  197 bits (502), Expect = 3e-50
 Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)

Query: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
           + R++V R+ I +++      I    P DLKK+L V+F GE+G+D GGV++E+  L+  E
Sbjct: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428

Query: 582 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 637
           + NP  G+F Y  ++  +   NP S    +    F  +G ++GLA+++   ++  F +  
Sbjct: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488

Query: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 697
           Y++L+GK     DL    P L++SL  +LE   ++   +  TF +   + FG  + ++LK
Sbjct: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545

Query: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
            NG  +P+T EN+KE+V LY ++   + +E QF A ++GF+ +  +  LK  F  +E+EL
Sbjct: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604

Query: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
           +I G   +D    +  T        DS ++R FW+ V +F +E++   LQF TG+ R P+
Sbjct: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663

Query: 818 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 867
            G   L+      GP          +T+ LP +HTCFN + +P Y S EKL E+LL A+ 
Sbjct: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723

Query: 868 YAKGFGM 874
              GF +
Sbjct: 724 ETCGFAV 730


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  197 bits (501), Expect = 4e-50
 Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)

Query: 453  PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 511
            PL   L++  +     V  E + + +T  PF++          ++ R++++ +R I    
Sbjct: 661  PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710

Query: 512  SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 567
              VQG    P+L    + +RR++I +DA  +L   + EN  DLKK++ V      G+DE 
Sbjct: 711  QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765

Query: 568  ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 617
                GG+ +EF   +++  FNP+ G F T +E   L + NP++    G      +  +G 
Sbjct: 766  GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823

Query: 618  VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 675
            +LG A+Y N ++++ F      KL+G         L    P +Y++L  L  YE +VE+ 
Sbjct: 824  MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882

Query: 676  MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 735
            + + F +   DL G   + +LK  G  IP+T+ NR  +++L +DY LN+ + +   AFR+
Sbjct: 883  LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941

Query: 736  GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 794
            G   V +   L+ +F  +EI++LI G++  +  + L+  T Y GGY+ D  +I+ FW +V
Sbjct: 942  GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000

Query: 795  HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 852
              FTDE+KR  L+F T   R P+ G  +L     I   G D ERLPT+ TC N+L LPE+
Sbjct: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060

Query: 853  SSKEKLKERLLKAITYAKGF 872
              +  L+ +LL AI  A GF
Sbjct: 1061 YDETLLRSKLLYAIECAAGF 1080


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
           sapiens]
          Length = 748

 Score =  193 bits (490), Expect = 7e-49
 Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)

Query: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
           L Q Q    + R++V R+ I +++      +    P DL K+L ++F GE+G+D GGV++
Sbjct: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439

Query: 573 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 628
           E+  L+  E+ NP  G+F Y  +       NP S    E    F  +G ++G+A+++   
Sbjct: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499

Query: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
           +D  F +  Y++L+GK  T  D+    P L+ SL  +LE   ++   +  TF +   + +
Sbjct: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556

Query: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
           G  + ++LK NG  IP+  EN+KE+V LY ++   + +E QF A ++GF+ V  +  LK 
Sbjct: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615

Query: 749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 808
            F  +E+EL+ICG   +D    +  T      T DS +++ FW+ V  F +E++   LQF
Sbjct: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674

Query: 809 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
            TG+ R P+       G  G     I +    T  LP +HTCFN + +P Y S EKL E+
Sbjct: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734

Query: 862 LLKAITYAKGFGM 874
           LL AI    GF +
Sbjct: 735 LLTAIEETCGFAV 747


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  192 bits (487), Expect = 1e-48
 Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)

Query: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
           L V RD I   +    E+++  N A LK+ + V F GE+G+ +G V +E+F ++  EI N
Sbjct: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610

Query: 585 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 641
           PD  +FT       F  N +S+        F   G +LGLA+ +  +++++F    Y+ +
Sbjct: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670

Query: 642 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 700
           +G    ++D+    P   ++L+ +L+   ++ D  + +TF + +TD+FG      LK  G
Sbjct: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727

Query: 701 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 760
             I +T  N+ E+V L ++  + ++++ Q  AF +GFHM    S ++ LF   E+ELL+ 
Sbjct: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786

Query: 761 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 816
           G   +D     + TEY  GY R+  +I+ FWE+V   T E++ L LQF TG+ R P    
Sbjct: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846

Query: 817 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 866
              +GG G     IA        LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,200,868
Number of Sequences: 37866
Number of extensions: 1461782
Number of successful extensions: 7309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 6826
Number of HSP's gapped (non-prelim): 327
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.