Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 19718762
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo
sapiens]
(852 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 1710 0.0
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 1710 0.0
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 1710 0.0
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 346 5e-95
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 301 1e-81
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 298 1e-80
gi|7657152 hect domain and RLD 3 [Homo sapiens] 279 9e-75
gi|110825982 hect domain and RLD 5 [Homo sapiens] 230 4e-60
gi|61563742 hect domain and RLD 6 [Homo sapiens] 226 7e-59
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 213 8e-55
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 213 8e-55
gi|222352183 neural precursor cell expressed, developmentally do... 204 3e-52
gi|21361472 neural precursor cell expressed, developmentally dow... 204 3e-52
gi|222352094 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352092 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352090 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352088 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352086 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352084 neural precursor cell expressed, developmentally do... 204 3e-52
gi|222352082 neural precursor cell expressed, developmentally do... 204 3e-52
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 204 4e-52
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 201 2e-51
gi|114520609 neural precursor cell expressed, developmentally do... 201 2e-51
gi|114520607 neural precursor cell expressed, developmentally do... 201 2e-51
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 201 2e-51
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 197 3e-50
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 197 3e-50
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 197 3e-50
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 193 6e-49
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 192 1e-48
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 1710 bits (4428), Expect = 0.0
Identities = 852/852 (100%), Positives = 852/852 (100%)
Query: 1 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60
MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC
Sbjct: 21 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 80
Query: 61 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120
DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER
Sbjct: 81 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 140
Query: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180
EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM
Sbjct: 141 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 200
Query: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240
EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL
Sbjct: 201 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 260
Query: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300
SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK
Sbjct: 261 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 320
Query: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360
LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV
Sbjct: 321 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 380
Query: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420
VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL
Sbjct: 381 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 440
Query: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480
IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS
Sbjct: 441 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 500
Query: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540
ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ
Sbjct: 501 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 560
Query: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600
GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI
Sbjct: 561 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 620
Query: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660
YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS
Sbjct: 621 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 680
Query: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720
QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE
Sbjct: 681 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 740
Query: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780
SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR
Sbjct: 741 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 800
Query: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840
LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
Sbjct: 801 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 860
Query: 841 KAITYAKGFGML 852
KAITYAKGFGML
Sbjct: 861 KAITYAKGFGML 872
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 1710 bits (4428), Expect = 0.0
Identities = 852/852 (100%), Positives = 852/852 (100%)
Query: 1 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60
MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC
Sbjct: 1 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60
Query: 61 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120
DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER
Sbjct: 61 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120
Query: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180
EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM
Sbjct: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180
Query: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240
EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL
Sbjct: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240
Query: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300
SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK
Sbjct: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300
Query: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360
LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV
Sbjct: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360
Query: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420
VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL
Sbjct: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420
Query: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480
IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS
Sbjct: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480
Query: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540
ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ
Sbjct: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540
Query: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600
GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI
Sbjct: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600
Query: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660
YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS
Sbjct: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660
Query: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720
QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE
Sbjct: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720
Query: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780
SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR
Sbjct: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780
Query: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840
LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
Sbjct: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840
Query: 841 KAITYAKGFGML 852
KAITYAKGFGML
Sbjct: 841 KAITYAKGFGML 852
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 1710 bits (4428), Expect = 0.0
Identities = 852/852 (100%), Positives = 852/852 (100%)
Query: 1 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60
MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC
Sbjct: 24 MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 83
Query: 61 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120
DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER
Sbjct: 84 DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 143
Query: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180
EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM
Sbjct: 144 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 203
Query: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240
EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL
Sbjct: 204 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 263
Query: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300
SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK
Sbjct: 264 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 323
Query: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360
LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV
Sbjct: 324 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 383
Query: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420
VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL
Sbjct: 384 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 443
Query: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480
IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS
Sbjct: 444 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 503
Query: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540
ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ
Sbjct: 504 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 563
Query: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600
GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI
Sbjct: 564 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 623
Query: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660
YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS
Sbjct: 624 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 683
Query: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720
QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE
Sbjct: 684 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 743
Query: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780
SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR
Sbjct: 744 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 803
Query: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840
LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
Sbjct: 804 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 863
Query: 841 KAITYAKGFGML 852
KAITYAKGFGML
Sbjct: 864 KAITYAKGFGML 875
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 346 bits (888), Expect = 5e-95
Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)
Query: 419 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 478
PLIP+ +F N L+ + M++ +T+ ++FSF PF+++ K + + D+ +M
Sbjct: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392
Query: 479 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 535
+ R +++ + + Q+ + +L +KVRR H++ D+L L ADLKK+L V
Sbjct: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448
Query: 536 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 595
F GE G+D GG++KE+F L++ +IF+PD GMFTY + + WF+ + +F L+GI+
Sbjct: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508
Query: 596 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 641
+GLA+YN+ LD+ FP Y+KL+ T DL P L L +
Sbjct: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
Query: 642 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 701
LL +EGNVE+D TFQ+ Q + FG Y+LK GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627
Query: 702 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 761
S+ KQF AF GFH V + L L RPEE+E+L+CGS +LD AL+ +T+YD GY +
Sbjct: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685
Query: 762 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 821
+ I+ FW++V F + ++ L FTTG+DR PVGG+ L I+KN T LP +HTCF
Sbjct: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745
Query: 822 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 851
N L LP Y SK+ LK++L+ I+ ++GFG+
Sbjct: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 301 bits (772), Expect = 1e-81
Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)
Query: 420 LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 473
+I +++F + E++++ DY + + + + T PF+ +A K L D
Sbjct: 610 IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669
Query: 474 NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 528
++M + R+ L + +NP L L VRR++I+ DA+ E++ D
Sbjct: 670 AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726
Query: 529 KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 588
KK L V F GE VD GGV KEFF L++ E+ +P GMF Y E ++L WF+ +FE
Sbjct: 727 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786
Query: 589 FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 647
F LIG++ GLAIYN I+D+HFP+ +Y+KL+ KK + DL + P + +S++ LL+Y E
Sbjct: 787 FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846
Query: 648 NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 707
++E+ + F I+ + FG + +L NG + +NR+EFV+ Y DYI NKSV F
Sbjct: 847 DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905
Query: 708 KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 767
AF GFH V L LF+P E++ ++ G+ N D++ LE+ TEY G Y + I+ F
Sbjct: 906 DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964
Query: 768 WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 827
WE+ H E+K+ FL F TG+DR P+ G+ LK++I G E LP SHTCFN+L LP
Sbjct: 965 WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024
Query: 828 EYSSKEKLKERLLKAITYAKGFGML 852
+Y+ KE L+ +L++AI + +GF ++
Sbjct: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 298 bits (763), Expect = 1e-80
Identities = 167/434 (38%), Positives = 255/434 (58%), Gaps = 12/434 (2%)
Query: 425 EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMY----- 479
++IN + MD ++ ++ + + T PF+ +A K L D ++M
Sbjct: 630 DYINWVQQQAYGMDVNHGLTEL-ADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQ 688
Query: 480 SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGE 539
+ R+ L + +NP L L VRR++I+ DA+ E++ D KK L V F GE
Sbjct: 689 AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDYKKPLKVIFVGE 745
Query: 540 QGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLA 599
VD GGV KEFF L++ E+ +P GMF Y E ++L WF+ +FE F LIG++ GLA
Sbjct: 746 DAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLA 805
Query: 600 IYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQ 658
IYN I+D+HFP+ +Y+KL+ KK + DL + P + +S++ LL+Y E ++E+ + F
Sbjct: 806 IYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFT 865
Query: 659 ISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVT 718
I+ + FG + +L NG + +NR+EFV+ Y DYI NKSV F AF GFH V
Sbjct: 866 IT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVC 924
Query: 719 NESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQ 778
L LF+P E++ ++ G+ N D++ LE+ TEY G Y + I+ FWE+ H E+
Sbjct: 925 GGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEK 983
Query: 779 KRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
K+ FL F TG+DR P+ G+ LK++I G E LP SHTCFN+L LP+Y+ KE L+ +
Sbjct: 984 KKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSK 1043
Query: 839 LLKAITYAKGFGML 852
L++AI + +GF ++
Sbjct: 1044 LIQAIDHNEGFSLI 1057
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 279 bits (713), Expect = 9e-75
Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)
Query: 421 IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 470
+ ++ F ++ ++++ +DY + + ++ + + PFI +A K L
Sbjct: 607 VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666
Query: 471 YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 524
D ++M + + + +L +L +P+L L VRR++++ DAL L ++ +
Sbjct: 667 QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723
Query: 525 PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 584
DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP GMFTY + + L WF+ + F
Sbjct: 724 DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783
Query: 585 TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 644
F LIGI GLAIYN+ ++D+HFP+ +Y+KL+ K DL + P +SL++LL+
Sbjct: 784 EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843
Query: 645 YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 703
Y G +VE+ + F I + + +G L GD + + +NR+EFV+ Y +Y+ SV
Sbjct: 844 YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902
Query: 704 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 763
+ + AF GF V L+ LF+P E+ ++ G+ N +++ LEET Y G Y+
Sbjct: 903 HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961
Query: 764 IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 823
++ FWE H F E+K+ FL F TG+DR P+ G+ L+++I E LP +HTC+N+
Sbjct: 962 VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021
Query: 824 LLLPEYSSKEKLKERLLKAITYAKGFGM 851
L LP+YSSKE L RL +A+ +GF +
Sbjct: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 230 bits (587), Expect = 4e-60
Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)
Query: 411 VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 462
V + C+ P + +E ++ LN +E+ + Y +K+ + + C PFI N
Sbjct: 580 VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637
Query: 463 AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 516
++K L+ D +++ S++ L S ++ L P L VRR+H+I+D L +
Sbjct: 638 NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697
Query: 517 LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 576
L E DL+K+L+V F GE G D GGV KEFF + E+ P+ GMF Y E
Sbjct: 698 LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754
Query: 577 WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 636
WF + ++ G++ GL+++N + ++ FP+ +++KL+ + + DL + P L
Sbjct: 755 WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814
Query: 637 QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 693
++L+ LL+ EG N E+ I F + + D +L NG I + N++++V+
Sbjct: 815 KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867
Query: 694 YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 753
Y +YI N SV+ ++ FRRGF+ + +E +K LF PEE++ +I G+ + D++ E+ Y
Sbjct: 868 YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926
Query: 754 DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 813
+ GY I FW+ H T E+K+ FL F TGTDR + L +K+ ER
Sbjct: 927 EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986
Query: 814 LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 850
P + TCF+VL LP+YS+ E ++E L +AI +GFG
Sbjct: 987 DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 226 bits (576), Expect = 7e-59
Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)
Query: 411 VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 465
V +CR P F +N ++ ++ +D ET + F PFI N+++
Sbjct: 572 VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631
Query: 466 KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 519
K L D+ I+M SE++ +L +++Q + +P L+VRR ++ DAL +L
Sbjct: 632 KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689
Query: 520 IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 579
+ D K L VEF E + GGVS EFF + EE+ P+ GMF Y E WF
Sbjct: 690 -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748
Query: 580 PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 639
+ ++ L G++ GL+++N + ++ FP+ +Y+KL+ +K + DL + P L +SL
Sbjct: 749 AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
Query: 640 KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 696
+++L + ++ D + I F I Q D+ DL NG IP+ N++++V+ Y D
Sbjct: 809 QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861
Query: 697 YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 756
YI N SV+ ++ F+RGF+ V + L++ F PEE+ I G+ + D++ E+ ++Y+ G
Sbjct: 862 YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920
Query: 757 YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 815
Y + I+ FW+ H T ++K+ FL F TG DR G+ K++++ +ER P
Sbjct: 921 YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980
Query: 816 TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 849
TS TC N+L LP+YS+ E+++E L AI +GF
Sbjct: 981 TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 213 bits (541), Expect = 8e-55
Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)
Query: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 66 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122
Query: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 605
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182
Query: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240
Query: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V L+Y
Sbjct: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300
Query: 726 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 785
F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ LQF
Sbjct: 301 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 358
Query: 786 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+E+
Sbjct: 359 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 417
Query: 839 LLKAITYAKGFG 850
LL AI +GFG
Sbjct: 418 LLYAIEETEGFG 429
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 213 bits (541), Expect = 8e-55
Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)
Query: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561
Query: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 605
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621
Query: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679
Query: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V L+Y
Sbjct: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 739
Query: 726 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 785
F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ LQF
Sbjct: 740 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 797
Query: 786 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+E+
Sbjct: 798 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 856
Query: 839 LLKAITYAKGFG 850
LL AI +GFG
Sbjct: 857 LLYAIEETEGFG 868
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
Query: 848 GF 849
GF
Sbjct: 849 GF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949
Query: 848 GF 849
GF
Sbjct: 950 GF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828
Query: 848 GF 849
GF
Sbjct: 829 GF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828
Query: 848 GF 849
GF
Sbjct: 829 GF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941
Query: 848 GF 849
GF
Sbjct: 942 GF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 612 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 669
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 670 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 729
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 730 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 785
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 786 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 844
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 845 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 904
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 905 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 961
Query: 848 GF 849
GF
Sbjct: 962 GF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 620 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 677
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 678 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 737
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 738 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 793
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 794 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 852
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 853 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 912
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 913 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 969
Query: 848 GF 849
GF
Sbjct: 970 GF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
Query: 848 GF 849
GF
Sbjct: 849 GF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
Query: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
Query: 848 GF 849
GF
Sbjct: 849 GF 850
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 204 bits (518), Expect = 4e-52
Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)
Query: 500 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 559
+ + VRRDH+ +D+ L ++P ++K +LY+ FEGE+G D GG+ +E++ ++ E+
Sbjct: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073
Query: 560 FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 615
FNP +F ++ + NPSS F +G ++ A+Y+N +L+ +F Y
Sbjct: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
Query: 616 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 674
+ ++GK + D+ YQ L LLE + + D+ + ++ + FG + DLK
Sbjct: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190
Query: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
NG I +T EN+KE+V+L + ++ KQ AF GF+ + + L +F +E+EL
Sbjct: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249
Query: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
LI G +D L+ TEY Y +S+ I+ FW + SF + FLQF TGT + P+
Sbjct: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308
Query: 795 GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 846
G L K I ++ T+RLP++HTCFN L LP Y S EKL+ LL AI +
Sbjct: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368
Query: 847 KGFGM 851
+GFG+
Sbjct: 4369 EGFGL 4373
Score = 31.2 bits (69), Expect = 4.3
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 148 KQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQG 197
++HT+EE S +DED +DE+E+ +ED E D G
Sbjct: 2413 EEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDG 2462
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 201 bits (512), Expect = 2e-51
Identities = 127/372 (34%), Positives = 202/372 (54%), Gaps = 19/372 (5%)
Query: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
L Q L ++++ V R + +D+ + I P DL+++LYV F GE+G+D GG+++
Sbjct: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613
Query: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 605
E+F L+ E+ NP +F Y ++ NP+S + F IG + +A+++
Sbjct: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673
Query: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
+D F + Y++++ KK T +DL Y SL + + N+E+ + + ++
Sbjct: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731
Query: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
G +DLK G I +T EN+ E++ L +++ ++ V++Q KAF GF+ V L+Y
Sbjct: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQY 791
Query: 726 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 785
F +E+E+++CG + +D + T Y YTR+S I FW+ V +E + LQF
Sbjct: 792 -FDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLLQF 849
Query: 786 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
TGT R P+GG +L K I K G DT LP SHTCFN L LP Y S E+LKE+
Sbjct: 850 VTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEK 908
Query: 839 LLKAITYAKGFG 850
LL AI +GFG
Sbjct: 909 LLFAIEETEGFG 920
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 201 bits (512), Expect = 2e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602
Query: 562 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837
Query: 797 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894
Query: 848 GF 849
GF
Sbjct: 895 GF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 201 bits (512), Expect = 2e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 892 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949
Query: 562 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 950 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009
Query: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065
Query: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124
Query: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184
Query: 797 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241
Query: 848 GF 849
GF
Sbjct: 1242 GF 1243
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 201 bits (511), Expect = 2e-51
Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)
Query: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
++++ V R + +D+ + I +P DL+++L+V F GE+G+D GGV++E+F L+ E
Sbjct: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562
Query: 559 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 614
+ NP +F Y + NP+S+ F IG + +A+++ +D F +
Sbjct: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622
Query: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 673
Y++++ K +DL P Y SL + E N+E+ D+ + F + + ++ G +DL
Sbjct: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679
Query: 674 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 733
K NG I +T EN++E++ + +++ L++ VE+Q +AF GF+ + + L+Y F +E+E
Sbjct: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738
Query: 734 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 793
+L+CG + +D + Y Y R S I FW+ V +E++ LQF TGT R P
Sbjct: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797
Query: 794 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 846
VGG G K I K G + LP SHTCFN L LP Y S E+LKE+LL AI
Sbjct: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
Query: 847 KGFG 850
+GFG
Sbjct: 857 EGFG 860
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 197 bits (502), Expect = 3e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454
Query: 559 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 614
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
Query: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 674
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571
Query: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630
Query: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689
Query: 795 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 844
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749
Query: 845 YAKGFGM 851
GF +
Sbjct: 750 ETCGFAV 756
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 197 bits (502), Expect = 3e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428
Query: 559 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 614
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
Query: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 674
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545
Query: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604
Query: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663
Query: 795 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 844
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
Query: 845 YAKGFGM 851
GF +
Sbjct: 724 ETCGFAV 730
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 197 bits (501), Expect = 3e-50
Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)
Query: 430 PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 488
PL L++ + V E + + +T PF++ ++ R++++ +R I
Sbjct: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710
Query: 489 SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 544
VQG P+L + +RR++I +DA +L + EN DLKK++ V G+DE
Sbjct: 711 QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765
Query: 545 ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 594
GG+ +EF +++ FNP+ G F T +E L + NP++ G + +G
Sbjct: 766 GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823
Query: 595 VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 652
+LG A+Y N ++++ F KL+G L P +Y++L L YE +VE+
Sbjct: 824 MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882
Query: 653 MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 712
+ + F + DL G + +LK G IP+T+ NR +++L +DY LN+ + + AFR+
Sbjct: 883 LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941
Query: 713 GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 771
G V + L+ +F +EI++LI G++ + + L+ T Y GGY+ D +I+ FW +V
Sbjct: 942 GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000
Query: 772 HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 829
FTDE+KR L+F T R P+ G +L I G D ERLPT+ TC N+L LPE+
Sbjct: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060
Query: 830 SSKEKLKERLLKAITYAKGF 849
+ L+ +LL AI A GF
Sbjct: 1061 YDETLLRSKLLYAIECAAGF 1080
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 193 bits (490), Expect = 6e-49
Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)
Query: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
L Q Q + R++V R+ I +++ + P DL K+L ++F GE+G+D GGV++
Sbjct: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
Query: 550 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 605
E+ L+ E+ NP G+F Y + NP S E F +G ++G+A+++
Sbjct: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
Query: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
+D F + Y++L+GK T D+ P L+ SL +LE ++ + TF + + +
Sbjct: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556
Query: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
G + ++LK NG IP+ EN+KE+V LY ++ + +E QF A ++GF+ V + LK
Sbjct: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615
Query: 726 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 785
F +E+EL+ICG +D + T T DS +++ FW+ V F +E++ LQF
Sbjct: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674
Query: 786 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
TG+ R P+ G G I + T LP +HTCFN + +P Y S EKL E+
Sbjct: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734
Query: 839 LLKAITYAKGFGM 851
LL AI GF +
Sbjct: 735 LLTAIEETCGFAV 747
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 192 bits (487), Expect = 1e-48
Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)
Query: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
L V RD I + E+++ N A LK+ + V F GE+G+ +G V +E+F ++ EI N
Sbjct: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610
Query: 562 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 618
PD +FT F N +S+ F G +LGLA+ + +++++F Y+ +
Sbjct: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670
Query: 619 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 677
+G ++D+ P ++L+ +L+ ++ D + +TF + +TD+FG LK G
Sbjct: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727
Query: 678 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 737
I +T N+ E+V L ++ + ++++ Q AF +GFHM S ++ LF E+ELL+
Sbjct: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786
Query: 738 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 793
G +D + TEY GY R+ +I+ FWE+V T E++ L LQF TG+ R P
Sbjct: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846
Query: 794 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 843
+GG G IA LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,137,942
Number of Sequences: 37866
Number of extensions: 1414031
Number of successful extensions: 7183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 6705
Number of HSP's gapped (non-prelim): 318
length of query: 852
length of database: 18,247,518
effective HSP length: 111
effective length of query: 741
effective length of database: 14,044,392
effective search space: 10406894472
effective search space used: 10406894472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.