Guide to the Human Genome
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Search of human proteins with 195947374

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195947374 claudin 5 [Homo sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195947374 claudin 5 [Homo sapiens]                                 623   e-179
gi|195947372 claudin 5 [Homo sapiens]                                 623   e-179
gi|11141861 claudin 9 [Homo sapiens]                                  243   2e-64
gi|153792768 claudin 6 [Homo sapiens]                                 240   1e-63
gi|4502875 claudin 3 [Homo sapiens]                                   238   5e-63
gi|4502877 claudin 4 [Homo sapiens]                                   227   1e-59
gi|10863887 claudin 1 [Homo sapiens]                                  198   4e-51
gi|153792186 claudin 7 [Homo sapiens]                                 194   6e-50
gi|183979973 claudin 19 isoform a [Homo sapiens]                      187   1e-47
gi|183979975 claudin 19 isoform b [Homo sapiens]                      187   1e-47
gi|40788011 claudin 8 [Homo sapiens]                                  186   3e-47
gi|6912316 claudin 17 [Homo sapiens]                                  167   1e-41
gi|225703142 claudin 14 [Homo sapiens]                                166   2e-41
gi|21536294 claudin 14 [Homo sapiens]                                 166   2e-41
gi|225703138 claudin 14 [Homo sapiens]                                166   2e-41
gi|6912314 claudin 14 [Homo sapiens]                                  166   2e-41
gi|225703140 claudin 14 [Homo sapiens]                                166   2e-41
gi|9966781 claudin 2 [Homo sapiens]                                   149   2e-36
gi|5921465 claudin 10 isoform b [Homo sapiens]                        137   1e-32
gi|47716519 claudin 20 [Homo sapiens]                                 133   2e-31
gi|7656981 claudin 15 [Homo sapiens]                                  133   2e-31
gi|33598916 claudin 10 isoform a [Homo sapiens]                       122   3e-28
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]                119   4e-27
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                        118   7e-27
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]                117   1e-26
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]                117   1e-26
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                       115   4e-26
gi|162417973 claudin 22 [Homo sapiens]                                113   2e-25
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]                   105   4e-23
gi|157820127 claudin-like [Homo sapiens]                              103   1e-22

>gi|195947374 claudin 5 [Homo sapiens]
          Length = 303

 Score =  623 bits (1606), Expect = e-179
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP 60
           MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP
Sbjct: 1   MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP 60

Query: 61  GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF 120
           GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF
Sbjct: 61  GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF 120

Query: 121 LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL 180
           LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL
Sbjct: 121 LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL 180

Query: 181 FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS 240
           FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS
Sbjct: 181 FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS 240

Query: 241 QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK 300
           QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK
Sbjct: 241 QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK 300

Query: 301 NYV 303
           NYV
Sbjct: 301 NYV 303


>gi|195947372 claudin 5 [Homo sapiens]
          Length = 303

 Score =  623 bits (1606), Expect = e-179
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP 60
           MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP
Sbjct: 1   MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAP 60

Query: 61  GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF 120
           GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF
Sbjct: 61  GPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCLVGWGGLILACGLPMWQVTAF 120

Query: 121 LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL 180
           LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL
Sbjct: 121 LDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVAL 180

Query: 181 FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS 240
           FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS
Sbjct: 181 FVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVS 240

Query: 241 QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK 300
           QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK
Sbjct: 241 QKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK 300

Query: 301 NYV 303
           NYV
Sbjct: 301 NYV 303


>gi|11141861 claudin 9 [Homo sapiens]
          Length = 217

 Score =  243 bits (620), Expect = 2e-64
 Identities = 121/222 (54%), Positives = 160/222 (72%), Gaps = 9/222 (4%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S  LE+LG+ L ++GW G +++C LP+W+VTAF+ ++IV AQ  W+GLWMSCVVQSTG
Sbjct: 1   MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
            MQCKVYDS+LAL  ++QAARAL V A+LLA + L V + GAQCTTCV    AKAR+ LT
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLT 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
            GV+ L  G+L L+P+CW A+ ++++FY+P V  + K ELGA+LY+GWAA ALLM+GG L
Sbjct: 121 AGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGL 180

Query: 266 LCCGAWVCTGRPDLSFP----VKYSAPRRPTATGDYDKKNYV 303
           LCC    C   P +  P    + YS P R  A+G  DK++YV
Sbjct: 181 LCC---TCP-PPQVERPRGPRLGYSIPSRSGASG-LDKRDYV 217


>gi|153792768 claudin 6 [Homo sapiens]
          Length = 220

 Score =  240 bits (613), Expect = 1e-63
 Identities = 116/220 (52%), Positives = 158/220 (71%), Gaps = 2/220 (0%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M SA ++ILG+VL L+GW   +++C LPMW+VTAF+ ++IV AQ  W+GLWMSCVVQSTG
Sbjct: 1   MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
            MQCKVYDS+LAL  ++QAARAL V A+L+A   L V LAGA+CTTCV    +KAR+ LT
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
            G++++  G+L L+P+CW A+ ++R+FY+P V  +QK ELGA+LY+GWAA+ LL++GG L
Sbjct: 121 SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL 180

Query: 266 LCCGAWVCTGRPDLSFPVKY--SAPRRPTATGDYDKKNYV 303
           LCC       +    +  +Y  SAP       +Y  KNYV
Sbjct: 181 LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV 220


>gi|4502875 claudin 3 [Homo sapiens]
          Length = 220

 Score =  238 bits (607), Expect = 5e-63
 Identities = 121/222 (54%), Positives = 153/222 (68%), Gaps = 9/222 (4%)

Query: 88  SAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHM 147
           S  LEI G  L ++GW G I+ C LPMW+V+AF+  NI+T+Q  W+GLWM+CVVQSTG M
Sbjct: 2   SMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQM 61

Query: 148 QCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGG 207
           QCKVYDS+LAL  ++QAARAL V A+LLA   L V L GAQCT CV    AKA++ +  G
Sbjct: 62  QCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAG 121

Query: 208 VLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267
           VL+L   LL LVP+ W AN ++R+FY+P VP +QK E+GA LY+GWAA AL ++GG LLC
Sbjct: 122 VLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLC 181

Query: 268 CGAWVCTGRPD--LSFPVKYSAPRR--PTAT--GDYDKKNYV 303
           C    C  R     +  V YSAPR   P A+    YD+K+YV
Sbjct: 182 CS---CPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV 220


>gi|4502877 claudin 4 [Homo sapiens]
          Length = 209

 Score =  227 bits (578), Expect = 1e-59
 Identities = 101/209 (48%), Positives = 150/209 (71%), Gaps = 3/209 (1%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S  L+++G+ L ++GW  ++L C LPMW+VTAF+  NIVT+QT W+GLWM+CVVQSTG
Sbjct: 1   MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
            MQCKVYDS+LAL  ++QAARAL + ++++A + + +++ G +CT C+    AKA+  + 
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIV 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
            GV++L  GL+ +VP+ W A+ ++++FY+P V   QK E+GA+LY+GWAA+ LL++GG L
Sbjct: 121 AGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LCC    C  R D  +  KYSA R   A+
Sbjct: 181 LCCN---CPPRTDKPYSAKYSAARSAAAS 206


>gi|10863887 claudin 1 [Homo sapiens]
          Length = 211

 Score =  198 bits (504), Expect = 4e-51
 Identities = 97/219 (44%), Positives = 138/219 (63%), Gaps = 9/219 (4%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M +A L++LG +L  +GW G I++  LP W++ ++   NIVTAQ  ++GLWMSCV QSTG
Sbjct: 1   MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPA-KARVAL 204
            +QCKV+DS+L LS+ +QA RAL V  +LL  +A+FV   G +C  C+      K R+A+
Sbjct: 61  QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV 120

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
            GG ++L  GL  LV   W+ N +V+EFYDP  PV+ +YE G AL+ GWAA +L ++GG 
Sbjct: 121 IGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGA 180

Query: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKNYV 303
           LLCC       R   S+P     P+   ++G    K+YV
Sbjct: 181 LLCCSC----PRKTTSYPTPRPYPKPAPSSG----KDYV 211


>gi|153792186 claudin 7 [Homo sapiens]
          Length = 211

 Score =  194 bits (494), Expect = 6e-50
 Identities = 87/184 (47%), Positives = 128/184 (69%), Gaps = 1/184 (0%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M ++ L++LG  + L+GW GL+    +P WQ++++   NI+TAQ  +KGLWM CV QSTG
Sbjct: 1   MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPA-KARVAL 204
            M CK+YDSVLALS  +QA RAL V +++L F+A+FV   G +CT C       KAR+A+
Sbjct: 61  MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM 120

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
            GG++++  GL ALV   W+ + +V +FY+P +P + KYE G A++IGWA +AL+++GG 
Sbjct: 121 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA 180

Query: 265 LLCC 268
           LL C
Sbjct: 181 LLSC 184


>gi|183979973 claudin 19 isoform a [Homo sapiens]
          Length = 224

 Score =  187 bits (475), Expect = 1e-47
 Identities = 91/207 (43%), Positives = 131/207 (63%), Gaps = 7/207 (3%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M ++ L++LG  L L GW G+I +  LP W+ +++    I+TA   ++GLWMSC  QSTG
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVAL 204
            +QCK+YDS+LAL   +Q+ARAL V AVLL FVA+ +++ G +CT      P AK RVA+
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
            GG L++  GL  L  + W+A +V +EF++PS PV+ +YE G AL++GWA+  L ++GG 
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRP 291
            LCC        P+   P     P RP
Sbjct: 181 FLCCTC------PEPERPNSSPQPYRP 201


>gi|183979975 claudin 19 isoform b [Homo sapiens]
          Length = 211

 Score =  187 bits (475), Expect = 1e-47
 Identities = 91/207 (43%), Positives = 131/207 (63%), Gaps = 7/207 (3%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M ++ L++LG  L L GW G+I +  LP W+ +++    I+TA   ++GLWMSC  QSTG
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVAL 204
            +QCK+YDS+LAL   +Q+ARAL V AVLL FVA+ +++ G +CT      P AK RVA+
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
            GG L++  GL  L  + W+A +V +EF++PS PV+ +YE G AL++GWA+  L ++GG 
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRP 291
            LCC        P+   P     P RP
Sbjct: 181 FLCCTC------PEPERPNSSPQPYRP 201


>gi|40788011 claudin 8 [Homo sapiens]
          Length = 225

 Score =  186 bits (471), Expect = 3e-47
 Identities = 90/213 (42%), Positives = 134/213 (62%), Gaps = 5/213 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M + ALEI GL L  VG  G +    +P W+V+AF+++NIV  +  W+GLWM+CV Q+  
Sbjct: 1   MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANI 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPG-PAKARVAL 204
            MQCK+YDS+LALS ++QAAR L  +A +++F+A  + + G +CT C       KA + L
Sbjct: 61  RMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILL 120

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
           T G++++  G++ L+P+ W AN ++R+FY+  V V+QK ELG ALY+GW    +L+VGG 
Sbjct: 121 TAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGA 180

Query: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDY 297
           L CC  + C    + S   +YS P   T    Y
Sbjct: 181 LFCC-VFCCN---EKSSSYRYSIPSHRTTQKSY 209


>gi|6912316 claudin 17 [Homo sapiens]
          Length = 224

 Score =  167 bits (423), Expect = 1e-41
 Identities = 87/221 (39%), Positives = 131/221 (59%), Gaps = 10/221 (4%)

Query: 91  LEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCK 150
           L+I GLVL  +G  G +    LP W+V+AF+  NI+  +  W+GLWM+C+ Q+   +QCK
Sbjct: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65

Query: 151 VYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVALTGGVL 209
            Y S+LAL   ++ ARAL   AV L+ +AL + + G +   C      AKA +  T GVL
Sbjct: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125

Query: 210 YLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCG 269
           ++  G+  L+P+ W ANI++R+FY+P++ + QK ELGAAL++GWA+ A+L +GG LLC  
Sbjct: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLC-- 183

Query: 270 AWVCTGR-------PDLSFPVKYSAPRRPTATGDYDKKNYV 303
            + C  R       P   + V ++  RR T        +YV
Sbjct: 184 GFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224


>gi|225703142 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (420), Expect = 2e-41
 Identities = 87/209 (41%), Positives = 126/209 (60%), Gaps = 6/209 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S A+++LG +L  +G  G ++   LP W+ TA +  NI+TA +  KGLWM CV  STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC++Y S+LAL  ++QAARAL V + LL+ +A    + G +CT C    PAK   A+ 
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GG L++  GLL +V + W  N VV+ FY+P +P   K+E+G ALY+G+ +++L ++GG L
Sbjct: 121 GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LC          D +    Y AP R T T
Sbjct: 181 LCLSC------QDEAPYRPYQAPPRATTT 203


>gi|21536294 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (420), Expect = 2e-41
 Identities = 87/209 (41%), Positives = 126/209 (60%), Gaps = 6/209 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S A+++LG +L  +G  G ++   LP W+ TA +  NI+TA +  KGLWM CV  STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC++Y S+LAL  ++QAARAL V + LL+ +A    + G +CT C    PAK   A+ 
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GG L++  GLL +V + W  N VV+ FY+P +P   K+E+G ALY+G+ +++L ++GG L
Sbjct: 121 GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LC          D +    Y AP R T T
Sbjct: 181 LCLSC------QDEAPYRPYQAPPRATTT 203


>gi|225703138 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (420), Expect = 2e-41
 Identities = 87/209 (41%), Positives = 126/209 (60%), Gaps = 6/209 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S A+++LG +L  +G  G ++   LP W+ TA +  NI+TA +  KGLWM CV  STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC++Y S+LAL  ++QAARAL V + LL+ +A    + G +CT C    PAK   A+ 
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GG L++  GLL +V + W  N VV+ FY+P +P   K+E+G ALY+G+ +++L ++GG L
Sbjct: 121 GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LC          D +    Y AP R T T
Sbjct: 181 LCLSC------QDEAPYRPYQAPPRATTT 203


>gi|6912314 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (420), Expect = 2e-41
 Identities = 87/209 (41%), Positives = 126/209 (60%), Gaps = 6/209 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S A+++LG +L  +G  G ++   LP W+ TA +  NI+TA +  KGLWM CV  STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC++Y S+LAL  ++QAARAL V + LL+ +A    + G +CT C    PAK   A+ 
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GG L++  GLL +V + W  N VV+ FY+P +P   K+E+G ALY+G+ +++L ++GG L
Sbjct: 121 GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LC          D +    Y AP R T T
Sbjct: 181 LCLSC------QDEAPYRPYQAPPRATTT 203


>gi|225703140 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (420), Expect = 2e-41
 Identities = 87/209 (41%), Positives = 126/209 (60%), Gaps = 6/209 (2%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S A+++LG +L  +G  G ++   LP W+ TA +  NI+TA +  KGLWM CV  STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC++Y S+LAL  ++QAARAL V + LL+ +A    + G +CT C    PAK   A+ 
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GG L++  GLL +V + W  N VV+ FY+P +P   K+E+G ALY+G+ +++L ++GG L
Sbjct: 121 GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL 180

Query: 266 LCCGAWVCTGRPDLSFPVKYSAPRRPTAT 294
           LC          D +    Y AP R T T
Sbjct: 181 LCLSC------QDEAPYRPYQAPPRATTT 203


>gi|9966781 claudin 2 [Homo sapiens]
          Length = 230

 Score =  149 bits (377), Expect = 2e-36
 Identities = 69/182 (37%), Positives = 115/182 (63%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M S  L+++G +L L+G  G ++A  LP W+ ++++  +IVTA    KGLWM C   STG
Sbjct: 1   MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
             QC +Y ++L L  ++QAA+A+ V++  ++ +A  +++ G +CT       AK RVA+ 
Sbjct: 61  ITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVA 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GGV ++  GLL  +P+ W  + ++R+FY P VP S K+E+G ALY+G  ++   ++ G +
Sbjct: 121 GGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGII 180

Query: 266 LC 267
           LC
Sbjct: 181 LC 182


>gi|5921465 claudin 10 isoform b [Homo sapiens]
          Length = 228

 Score =  137 bits (345), Expect = 1e-32
 Identities = 71/184 (38%), Positives = 108/184 (58%), Gaps = 6/184 (3%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPM--WQVTAFLDHNIVTAQTTWKGLWMSCVVQS 143
           M S A EI+  ++ + GW  ++++  LP   W+V+  +D  ++T  T W  LW +CV  S
Sbjct: 1   MASTASEIIAFMVSISGW--VLVSSTLPTDYWKVST-IDGTVITTATYWANLWKACVTDS 57

Query: 144 TGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVA 203
           TG   CK + S+LAL   +QA R L ++AV L F      L G +CT       AKA++A
Sbjct: 58  TGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIA 117

Query: 204 LTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGG 263
              G++++  GL ++     +AN +  EF+DP + V QKYELGAAL+IGWA  +L ++GG
Sbjct: 118 CLAGIVFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGG 176

Query: 264 CLLC 267
            + C
Sbjct: 177 VIFC 180


>gi|47716519 claudin 20 [Homo sapiens]
          Length = 219

 Score =  133 bits (335), Expect = 2e-31
 Identities = 66/182 (36%), Positives = 100/182 (54%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M SA L++L  +L L G  G++ A  LP W+V   +D NI+TA     GLWM C   STG
Sbjct: 1   MASAGLQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTG 60

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALT 205
              C +  S+L+L   VQAARA  V A +L+ + +  +  G +CT        K+  +  
Sbjct: 61  MFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGGDRETKSHASFA 120

Query: 206 GGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCL 265
           GGV ++  G+ +L+   W+   ++  F D +VP S K+E G A+YIG+ +  LL + G +
Sbjct: 121 GGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESNKHEPGGAIYIGFISAMLLFISGMI 180

Query: 266 LC 267
            C
Sbjct: 181 FC 182


>gi|7656981 claudin 15 [Homo sapiens]
          Length = 228

 Score =  133 bits (335), Expect = 2e-31
 Identities = 82/219 (37%), Positives = 120/219 (54%), Gaps = 14/219 (6%)

Query: 88  SAALEILGLVLCLVGWGGLILACGLP--MWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           S A+E  G  +  VG   L+L   LP   W+V+  +  N++T  T ++ LW SC   S G
Sbjct: 2   SMAVETFGFFMATVGL--LMLGVTLPNSYWRVST-VHGNVITTNTIFENLWFSCATDSLG 58

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVA-PGPAKARVAL 204
              C  + S+LALS  +QA RAL ++A+LL F+ L + +AG +CT         KA++A 
Sbjct: 59  VYNCWEFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAA 118

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264
           T G L++  G+  +V + W+A  + R+F+DP  P   KYELG ALY+GW+A+ + ++GG 
Sbjct: 119 TAGALHILAGICGMVAISWYAFNITRDFFDPLYP-GTKYELGPALYLGWSASLISILGGL 177

Query: 265 LLCCGAWVCTGR---PDLSFPVKYSAP--RRPTATGDYD 298
            LC     C G    P  S    Y AP    P AT D +
Sbjct: 178 CLCSAC--CCGSDEDPAASARRPYQAPVSVMPVATSDQE 214


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score =  122 bits (307), Expect = 3e-28
 Identities = 62/176 (35%), Positives = 101/176 (57%), Gaps = 2/176 (1%)

Query: 92  EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151
           +I  LV  + G+G L+ A     W+VT     +++TA   ++GLWM+C   + G   C+ 
Sbjct: 5   QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFHCRP 63

Query: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211
           + ++  ++  +QA R L ++AV L F      L G +CT       AKA++A   G++++
Sbjct: 64  HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123

Query: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267
             GL ++     +AN +  EF+DP + V QKYELGAAL+IGWA  +L ++GG + C
Sbjct: 124 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 178


>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  119 bits (297), Expect = 4e-27
 Identities = 72/183 (39%), Positives = 105/183 (57%), Gaps = 5/183 (2%)

Query: 90  ALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQC 149
           A++ +GL+L L+GW   I+   LP W+    LD N +   T   GLW +CV+Q    MQC
Sbjct: 8   AMQSVGLLLSLLGWILSIITTYLPHWK-NLNLDLNEMENWTM--GLWQTCVIQEEVGMQC 64

Query: 150 KVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTC-VAPGPAKARVALTGGV 208
           K +DS LAL  E++ +R L   +  L F+ L V+  G  C     +    K R+ + GG+
Sbjct: 65  KDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGI 124

Query: 209 LYLFCGLLALVPLCWFANIVVREFYDPSVP-VSQKYELGAALYIGWAATALLMVGGCLLC 267
           L    G+ ALVP+ W A+  V+EF+D +VP    ++E G AL++GW A   L++GGCLL 
Sbjct: 125 LSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLN 184

Query: 268 CGA 270
           C A
Sbjct: 185 CAA 187


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score =  118 bits (295), Expect = 7e-27
 Identities = 62/194 (31%), Positives = 105/194 (54%), Gaps = 13/194 (6%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M +   +++  +L ++G  G I A G+ MW      D N VT+   ++GLW SCV QS+G
Sbjct: 1   MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYD-NPVTSVFQYEGLWRSCVRQSSG 59

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVA-PGPAKARVAL 204
             +C+ Y ++L L   +QA RAL +  ++L  + L V++   +C    +    AKA + L
Sbjct: 60  FTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSV-----------PVSQKYELGAALYIGW 253
           T G++++  GL A+  +  FAN++V  F+  +             V  +Y  GAAL++GW
Sbjct: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179

Query: 254 AATALLMVGGCLLC 267
            A  L ++GG ++C
Sbjct: 180 VAGGLTLIGGVMMC 193


>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  117 bits (293), Expect = 1e-26
 Identities = 71/183 (38%), Positives = 104/183 (56%), Gaps = 5/183 (2%)

Query: 90  ALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQC 149
           A++ +GL+L  +GW   I+   LP W+    LD N +   T   GLW +CV+Q    MQC
Sbjct: 8   AMQSVGLLLSFLGWILSIITTYLPHWK-NLNLDLNEMENWTM--GLWQTCVIQEEVGMQC 64

Query: 150 KVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTC-VAPGPAKARVALTGGV 208
           K +DS LAL  E++ +R L   +  L F+ L V+  G  C     +    K R+ + GG+
Sbjct: 65  KDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGI 124

Query: 209 LYLFCGLLALVPLCWFANIVVREFYDPSVP-VSQKYELGAALYIGWAATALLMVGGCLLC 267
           L    G+ ALVP+ W A+  V+EF+D +VP    ++E G AL++GW A   L++GGCLL 
Sbjct: 125 LSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLN 184

Query: 268 CGA 270
           C A
Sbjct: 185 CAA 187


>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  117 bits (293), Expect = 1e-26
 Identities = 71/183 (38%), Positives = 104/183 (56%), Gaps = 5/183 (2%)

Query: 90  ALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQC 149
           A++ +GL+L  +GW   I+   LP W+    LD N +   T   GLW +CV+Q    MQC
Sbjct: 8   AMQSVGLLLSFLGWILSIITTYLPHWK-NLNLDLNEMENWTM--GLWQTCVIQEEVGMQC 64

Query: 150 KVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTC-VAPGPAKARVALTGGV 208
           K +DS LAL  E++ +R L   +  L F+ L V+  G  C     +    K R+ + GG+
Sbjct: 65  KDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGI 124

Query: 209 LYLFCGLLALVPLCWFANIVVREFYDPSVP-VSQKYELGAALYIGWAATALLMVGGCLLC 267
           L    G+ ALVP+ W A+  V+EF+D +VP    ++E G AL++GW A   L++GGCLL 
Sbjct: 125 LSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLN 184

Query: 268 CGA 270
           C A
Sbjct: 185 CAA 187


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score =  115 bits (289), Expect = 4e-26
 Identities = 65/194 (33%), Positives = 106/194 (54%), Gaps = 13/194 (6%)

Query: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
           M   A + LG V+ L+G  G+I A  +  W  T  L +N VTA   ++GLW SCV +S+G
Sbjct: 1   MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59

Query: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVA-PGPAKARVAL 204
             +C+ Y ++L L   +QA RAL +  ++L  + L V++   +C    +    AKA + L
Sbjct: 60  FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119

Query: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSV-----------PVSQKYELGAALYIGW 253
           T G++++  GL A+  +  FAN++V  F+  +             V  +Y  GAAL++GW
Sbjct: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179

Query: 254 AATALLMVGGCLLC 267
            A  L ++GG ++C
Sbjct: 180 VAGGLTLIGGVMMC 193


>gi|162417973 claudin 22 [Homo sapiens]
          Length = 220

 Score =  113 bits (282), Expect = 2e-25
 Identities = 70/181 (38%), Positives = 101/181 (55%), Gaps = 5/181 (2%)

Query: 92  EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151
           ++ G+ L L+GW    L   LP W+    LD N +   T   GLW +CV+Q    MQCK 
Sbjct: 10  QLAGVSLSLLGWVLSCLTNYLPHWK-NLNLDLNEMENWTM--GLWQTCVIQEEVGMQCKD 66

Query: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTC-VAPGPAKARVALTGGVLY 210
           +DS LAL  E++ +R L   +  L F+ L V+  G  C     +    K R+ + GG+L 
Sbjct: 67  FDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILS 126

Query: 211 LFCGLLALVPLCWFANIVVREFYDPSVP-VSQKYELGAALYIGWAATALLMVGGCLLCCG 269
              G+ ALVP+ W A+  V+EF+D +VP    ++E G AL++GW A   L++GGCLL C 
Sbjct: 127 WASGVTALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLHCA 186

Query: 270 A 270
           A
Sbjct: 187 A 187


>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
          Length = 207

 Score =  105 bits (263), Expect = 4e-23
 Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 21/176 (11%)

Query: 92  EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151
           +I  LV  + G+G L+ A     W+VT     +++TA   ++GLWM+C     G+     
Sbjct: 5   QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA----GY----- 54

Query: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211
                     +QA R L ++AV L F      L G +CT       AKA++A   G++++
Sbjct: 55  ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104

Query: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267
             GL ++     +AN +  EF+DP + V QKYELGAAL+IGWA  +L ++GG + C
Sbjct: 105 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 159


>gi|157820127 claudin-like [Homo sapiens]
          Length = 229

 Score =  103 bits (258), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 7/197 (3%)

Query: 89  AALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQ 148
           A +++ GL+L L+GW    +   LP W+    L+  +   +T   G+W  CV +      
Sbjct: 7   AKVQLGGLLLSLLGWVCSCVTTILPQWKT---LNLELNEMETWIMGIWEVCVDREEVATV 63

Query: 149 CKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTC-VAPGPAKARVALTGG 207
           CK ++S L+L  E+Q AR L V++  L  + L +   G++C          K R+ L G 
Sbjct: 64  CKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGR 123

Query: 208 VLYLFCGLLALVPLCWFANIVVREFYDPSVP-VSQKYELGAALYIGWAATALLMVGGCLL 266
            L        L+P+ W A+  +++F+D S+P +  ++E G ALY+GWAA   L +GG LL
Sbjct: 124 TLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLL 183

Query: 267 CCGAWVCTGRPDLSFPV 283
              A  C G+ D+ FP+
Sbjct: 184 IFSA--CLGKEDVPFPL 198


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,172,423
Number of Sequences: 37866
Number of extensions: 632321
Number of successful extensions: 3697
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 3452
Number of HSP's gapped (non-prelim): 316
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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