Search of human proteins with 194353989

Search of human proteins with 194353989

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform
1 [Homo sapiens]
         (704 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1...  1475   0.0  
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ...  1289   0.0  
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ...   451   e-126
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ...   451   e-126
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H...   449   e-126
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi...   301   1e-81
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi...   285   8e-77
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo...   127   4e-29
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo...   126   8e-29
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo...   115   1e-25
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo...   113   5e-25
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor...   111   3e-24
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ...   102   1e-21
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ...   102   1e-21
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ...   102   1e-21
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo...    96   1e-19
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho...    93   1e-18
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    39   0.013
gi|5453810 netrin 3 [Homo sapiens]                                     39   0.022
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    38   0.037
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    38   0.037
gi|109689723 abl interactor 2 [Homo sapiens]                           37   0.048
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    37   0.048
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]        37   0.082
gi|169204928 PREDICTED: hypothetical protein [Homo sapiens]            37   0.082
gi|113423861 PREDICTED: hypothetical protein [Homo sapiens]            37   0.082
gi|113423437 PREDICTED: hypothetical protein [Homo sapiens]            37   0.082
gi|117938310 sine oculis binding protein homolog [Homo sapiens]        37   0.082
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                    37   0.082
gi|7657665 zinc finger and BTB domain containing 32 [Homo sapiens]     37   0.082

>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
           [Homo sapiens]
          Length = 704

 Score = 1475 bits (3818), Expect = 0.0
 Identities = 704/704 (100%), Positives = 704/704 (100%)

Query: 1   MAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPG 60
           MAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPG
Sbjct: 1   MAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPG 60

Query: 61  PVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPA 120
           PVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPA
Sbjct: 61  PVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPA 120

Query: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180
           SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP
Sbjct: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180

Query: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAAL 240
           VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAAL
Sbjct: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAAL 240

Query: 241 SATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYH 300
           SATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYH
Sbjct: 241 SATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYH 300

Query: 301 FHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWT 360
           FHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWT
Sbjct: 301 FHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWT 360

Query: 361 AQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATIS 420
           AQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATIS
Sbjct: 361 AQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATIS 420

Query: 421 IREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPL 480
           IREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPL
Sbjct: 421 IREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPL 480

Query: 481 PAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKS 540
           PAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKS
Sbjct: 481 PAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKS 540

Query: 541 AGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSL 600
           AGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSL
Sbjct: 541 AGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSL 600

Query: 601 WFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPP 660
           WFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPP
Sbjct: 601 WFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPP 660

Query: 661 AGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT 704
           AGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
Sbjct: 661 AGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT 704


>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
           [Homo sapiens]
          Length = 638

 Score = 1289 bits (3336), Expect = 0.0
 Identities = 617/617 (100%), Positives = 617/617 (100%)

Query: 88  QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 147
           QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN
Sbjct: 22  QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 81

Query: 148 RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 207
           RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP
Sbjct: 82  RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 141

Query: 208 SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS 267
           SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS
Sbjct: 142 SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS 201

Query: 268 RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL 327
           RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL
Sbjct: 202 RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL 261

Query: 328 SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST 387
           SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST
Sbjct: 262 SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST 321

Query: 388 LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL 447
           LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL
Sbjct: 322 LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL 381

Query: 448 LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE 507
           LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE
Sbjct: 382 LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE 441

Query: 508 THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI 567
           THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI
Sbjct: 442 THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI 501

Query: 568 NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG 627
           NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG
Sbjct: 502 NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG 561

Query: 628 GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV 687
           GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV
Sbjct: 562 GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV 621

Query: 688 SAEESWAGPQPLETLDT 704
           SAEESWAGPQPLETLDT
Sbjct: 622 SAEESWAGPQPLETLDT 638


>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
           [Homo sapiens]
          Length = 728

 Score =  451 bits (1160), Expect = e-126
 Identities = 242/657 (36%), Positives = 358/657 (54%), Gaps = 38/657 (5%)

Query: 32  LPPQWLSTEAWTGEWKQPHGGALTSRSPGPVAP----QRPCHLKGWQHRPTQHNAACKQG 87
           L P   S ++  G  K   G  L  + P P+ P         L+     P Q      +G
Sbjct: 26  LDPDPCSPQSTPGLMK---GNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKG 82

Query: 88  QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 147
               +    P  P+AP  P  E  +E L+E   S+REL  FFC N TIHGAIRLVCS+ N
Sbjct: 83  NKREEQGLGP-EPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHN 139

Query: 148 RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 207
           R+KT  W +L L     + WQ GLLF  ++  PV + ++++S++ + P VT+C  NP R 
Sbjct: 140 RMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRY 199

Query: 208 SPVLRHLELLDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLD 254
             +   LE LD    + +  LY  +        S+ R  L  T+P      R  PP H  
Sbjct: 200 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 259

Query: 255 REIR--LQRLSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDIL 307
           R  R     L  +  +V     ++GF+LCN    DCFY+ Y+SGV AV++WY FHY++IL
Sbjct: 260 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 319

Query: 308 ALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQ 362
           + LP           G+F+ +C ++ + C    +  FHHP YG+CYT +      +W + 
Sbjct: 320 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 379

Query: 363 RPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIR 422
            PGI +G+ L+LR EQ   +PLLST+ G RVMVHG++   F+    F++RPG E +IS+R
Sbjct: 380 MPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMR 439

Query: 423 EDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPA 482
           ++ + RLG  YG CT  G  V VE L+ + YT+Q C+ SCFQ+ M++ C C Y  +P P 
Sbjct: 440 KETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ 499

Query: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542
             EYC   +H +WG+C+Y+L  D  +  L C ++C +PC  ++++LS G SRWPS  S  
Sbjct: 500 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQE 559

Query: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602
           W    L  Q   +  + +R+ +AK+NI ++ELNY++  E+P  ++  LLS +GS  SLWF
Sbjct: 560 WVFQMLSRQN-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWF 618

Query: 603 GASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 659
           G+SVLS++E+ EL+ D   +  ++  RR R  +  W       GA  +    +  PP
Sbjct: 619 GSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 673


>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
           [Homo sapiens]
          Length = 692

 Score =  451 bits (1159), Expect = e-126
 Identities = 237/638 (37%), Positives = 351/638 (55%), Gaps = 35/638 (5%)

Query: 51  GGALTSRSPGPVAP----QRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPP 106
           G  L  + P P+ P         L+     P Q      +G    +    P  P+AP  P
Sbjct: 6   GNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGP-EPAAPQQP 64

Query: 107 PKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALC 166
             E  +E L+E   S+REL  FFC N TIHGAIRLVCS+ NR+KT  W +L L     + 
Sbjct: 65  TAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMY 122

Query: 167 WQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENID 226
           WQ GLLF  ++  PV + ++++S++ + P VT+C  NP R   +   LE LD    + + 
Sbjct: 123 WQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLF 182

Query: 227 SLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQRLSHSGSRV-- 269
            LY  +        S+ R  L  T+P      R  PP H  R  R     L  +  +V  
Sbjct: 183 DLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDW 242

Query: 270 ---RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFV 326
              ++GF+LCN    DCFY+ Y+SGV AV++WY FHY++IL+ LP           G+F+
Sbjct: 243 KDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFI 302

Query: 327 LSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVGLVLRVEQQPH 381
            +C ++ + C    +  FHHP YG+CYT +      +W +  PGI +G+ L+LR EQ   
Sbjct: 303 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 362

Query: 382 LPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGE 441
           +PLLST+ G RVMVHG++   F+    F++RPG E +IS+R++ + RLG  YG CT  G 
Sbjct: 363 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 422

Query: 442 GVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYR 501
            V VE L+ + YT+Q C+ SCFQ+ M++ C C Y  +P P   EYC   +H +WG+C+Y+
Sbjct: 423 DVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYK 482

Query: 502 LYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQR 561
           L  D  +  L C ++C +PC  ++++LS G SRWPS  S  W    L  Q   +  + +R
Sbjct: 483 LQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN-NYTVNNKR 541

Query: 562 SSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASA 621
           + +AK+NI ++ELNY++  E+P  ++  LLS +GS  SLWFG+SVLS++E+ EL+ D   
Sbjct: 542 NGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLV 601

Query: 622 LTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 659
           +  ++  RR R  +  W       GA  +    +  PP
Sbjct: 602 IMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 637


>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
           sapiens]
          Length = 669

 Score =  449 bits (1155), Expect = e-126
 Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)

Query: 98  GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 156
           GP P+AP  P  E  +E L+E   S+REL  FFC N TIHGAIRLVCS+ NR+KT  W +
Sbjct: 32  GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 89

Query: 157 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 216
           L L     + WQ GLLF  ++  PV + ++++S++ + P VT+C  NP R   +   LE 
Sbjct: 90  LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 149

Query: 217 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 261
           LD    + +  LY  +        S+ R  L  T+P      R  PP H  R  R     
Sbjct: 150 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 209

Query: 262 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 316
           L  +  +V     ++GF+LCN    DCFY+ Y+SGV AV++WY FHY++IL+ LP     
Sbjct: 210 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 269

Query: 317 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 371
                 G+F+ +C ++ + C    +  FHHP YG+CYT +      +W +  PGI +G+ 
Sbjct: 270 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 329

Query: 372 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 431
           L+LR EQ   +PLLST+ G RVMVHG++   F+    F++RPG E +IS+R++ + RLG 
Sbjct: 330 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389

Query: 432 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 491
            YG CT  G  V VE L+ + YT+Q C+ SCFQ+ M++ C C Y  +P P   EYC   +
Sbjct: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449

Query: 492 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 551
           H +WG+C+Y+L  D  +  L C ++C +PC  ++++LS G SRWPS  S  W    L  Q
Sbjct: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509

Query: 552 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 611
              +  + +R+ +AK+NI ++ELNY++  E+P  ++  LLS +GS  SLWFG+SVLS++E
Sbjct: 510 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568

Query: 612 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 659
           + EL+ D   +  ++  RR R  +  W       GA  +    +  PP
Sbjct: 569 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 614


>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
           sapiens]
          Length = 649

 Score =  301 bits (772), Expect = 1e-81
 Identities = 181/599 (30%), Positives = 290/599 (48%), Gaps = 53/599 (8%)

Query: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180
           + +EL+ ++C N   HG  R+V SRG RL+   W   +L A+  + WQ  LL    +   
Sbjct: 24  TIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLVFSFY--T 80

Query: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR--- 237
           V +++ VH  +   P VT+C+ NP + S V   L  L++  RE + SLY    S+ R   
Sbjct: 81  VSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREA 140

Query: 238 ----AALSATVPR--HEPP--------------FHLDREIRL--------QRLSHSGSRV 269
               +      PR  H  P              F   R+ ++          + H  S+ 
Sbjct: 141 ESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQ 200

Query: 270 RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 329
            VGF+LC++   DC    ++SG+ A+Q+WY  HY++I+A +P   + +        +++C
Sbjct: 201 VVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTC 260

Query: 330 SYDGLDCQARQFRTFHHPTYGSCYTVDG-----VWTAQRPGITHGVGLVLRVEQQPHLPL 384
            +DG+ C AR F  FHHP +G+CYT +      + +    G  +G+ ++L + ++ + P 
Sbjct: 261 FFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPF 320

Query: 385 LSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVE 444
           L +  G +V++H ++  PF+      +      +I +   E  +L  PY  CT  G  V 
Sbjct: 321 LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVP 380

Query: 445 VELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQ 504
           +  ++N +Y+ Q CL SCFQ  MVE C C  Y  PLP  A YC+  +HP W +C+Y+L++
Sbjct: 381 IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHR 440

Query: 505 DLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATL-GEQGLPHQSHRQRSS 563
                 L C S C   C    + L+T  ++WPS  S  W L  L  +QG        ++ 
Sbjct: 441 AFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD 500

Query: 564 LAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALT 623
           LAK+ I Y++LN RS+ E+P  S+  LLS  G    LW   SV+ ++E++E+        
Sbjct: 501 LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI 560

Query: 624 LVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP----PAGGTSDDPEP--SGPHLP 676
           +     +  + W++W +A P        PEA + P     PA    DD     S  HLP
Sbjct: 561 IARRQWQKAKEWWAWKQAPPC-------PEAPRSPQGQDNPALDIDDDLPTFNSALHLP 612


>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
           sapiens]
          Length = 640

 Score =  285 bits (730), Expect = 8e-77
 Identities = 176/605 (29%), Positives = 283/605 (46%), Gaps = 54/605 (8%)

Query: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180
           +++ELL ++C N   HG  R++C      K   W LL+L     +CWQ G+    +    
Sbjct: 21  TYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78

Query: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAA- 239
           V +++SV  +    P VT+C+ +P + S +   L+ LDE     ++ +    LS   A  
Sbjct: 79  VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATR 138

Query: 240 -LSATVPRHEPPFHLDRE-------IRLQRLSHSGSR-------------VRVGFRLCNS 278
            L+ ++  H P   +D         + L   +H+G                ++  RLC+ 
Sbjct: 139 NLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSL 198

Query: 279 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA 338
               C +R +TS   A+ +WY     +I A +P              +L+C +    C  
Sbjct: 199 NRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNY 258

Query: 339 RQFRTFHHPTYGSCYTVDGVWTAQ-----RPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 393
           R F +  +P YG+CY  +   T +      PG   G+ L+L + Q+ ++P L++ AG+R+
Sbjct: 259 RNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRL 318

Query: 394 MVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLH---N 450
           M+H +   PF+         GTE +I +  D++ R+G PY  CT  G  V V+  +   N
Sbjct: 319 MLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYN 378

Query: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 510
           T+Y+ QACL SCFQ  M+  C+CG+YL+PLP G +YC++   P W HC+  L   +   R
Sbjct: 379 TTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSV-AQR 437

Query: 511 LPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLG-EQGLPHQSHRQRSSLAKINI 569
             C   C   C ++ +K++   + WPS  S  W    L  E+         R  + K+NI
Sbjct: 438 ETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNI 497

Query: 570 VYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLV---- 625
            +QE NYR++EE+   ++  LLS +G     W G SVL L+E  E+++D   +T++    
Sbjct: 498 YFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVA 557

Query: 626 -LGGRRLRRAWFSWPRASP-------ASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPR 677
                R RRA  S+    P       A      +P+ +   P  G     P PS   LP 
Sbjct: 558 LAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTG-----PYPSEQALP- 611

Query: 678 VMLPG 682
             +PG
Sbjct: 612 --IPG 614


>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
           sapiens]
          Length = 666

 Score =  127 bits (319), Expect = 4e-29
 Identities = 147/606 (24%), Positives = 241/606 (39%), Gaps = 128/606 (21%)

Query: 105 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 160
           P  KE   E    G V   A+ R+L TF  T+ T+HG  R      + L+ T W L  L 
Sbjct: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203

Query: 161 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 220
           +L A  +Q   L   +  RP L+A+                 +P  P+PV     +    
Sbjct: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242

Query: 221 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 280
                 +L N+N  +  A   A +      FHL     L      G R            
Sbjct: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278

Query: 281 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 340
                       AA   +     VDIL        +  G Q    + SC++ G  C A  
Sbjct: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318

Query: 341 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 390
           F   +   YG CYT +    +  P    G+  G+ ++L ++Q+ +LP+       S  AG
Sbjct: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377

Query: 391 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 450
           IRV +H +   P++    F V PG +  +S +E  +  L  P+G+C A  E  E EL   
Sbjct: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437

Query: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 510
           ++Y+  AC + C ++ +++ C C   +  +P     C              +Y +   H 
Sbjct: 438 SAYSVSACRLRCEKEAVLQRCHC--RMVHMPGNETICPP-----------NIYIECADHT 484

Query: 511 L---------PCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQR 561
           L         PC   CP PC  + +       R P+  SA +    L  +   ++++ + 
Sbjct: 485 LDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRE 538

Query: 562 SSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASA 621
           + L  +++ ++ L   ++E+   Y +  LL  +G    L+ GAS+L+LLE+L+ + + S 
Sbjct: 539 NFLV-LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS- 596

Query: 622 LTLVLGGRRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEP 670
                   RL+R W     P  +   G S+  ++    Q P P+ G ++        P  
Sbjct: 597 ------WDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNH 650

Query: 671 SGPHLP 676
             PH P
Sbjct: 651 HHPHGP 656


>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
           sapiens]
          Length = 647

 Score =  126 bits (316), Expect = 8e-29
 Identities = 147/599 (24%), Positives = 237/599 (39%), Gaps = 133/599 (22%)

Query: 105 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 160
           P  KE   E    G V   A+ R+L TF  T+ T+HG  R      + L+ T W L  L 
Sbjct: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203

Query: 161 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 220
           +L A  +Q   L   +  RP L+A+                 +P  P+PV     +    
Sbjct: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242

Query: 221 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 280
                 +L N+N  +  A   A +      FHL     L      G R            
Sbjct: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278

Query: 281 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 340
                       AA   +     VDIL        +  G Q    + SC++ G  C A  
Sbjct: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318

Query: 341 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 390
           F   +   YG CYT +    +  P    G+  G+ ++L ++Q+ +LP+       S  AG
Sbjct: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377

Query: 391 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 450
           IRV +H +   P++    F V PG +  +S +E  +  L  P+G+C A  E  E EL   
Sbjct: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437

Query: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHP--LPAGAEYCSSARHPAWGHCFYRLYQDLET 508
           ++Y+  AC + C ++ +++ C C     P  L  G E          G CF         
Sbjct: 438 SAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPE----------GPCF--------- 478

Query: 509 HRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKIN 568
                   CP PC  + +       R P+  SA +    L  +   ++++ + + L  ++
Sbjct: 479 --------CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRENFLV-LD 525

Query: 569 IVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGG 628
           + ++ L   ++E+   Y +  LL  +G    L+ GAS+L+LLE+L+ + + S        
Sbjct: 526 VFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS-------W 578

Query: 629 RRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEPSGPHLP 676
            RL+R W     P  +   G S+  ++    Q P P+ G ++        P    PH P
Sbjct: 579 DRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGP 637


>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
           1 [Homo sapiens]
          Length = 563

 Score =  115 bits (288), Expect = 1e-25
 Identities = 79/321 (24%), Positives = 147/321 (45%), Gaps = 28/321 (8%)

Query: 310 LPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQR 363
           + AA+ D  G Q    +LSC Y G  C    F +     YG CY  +       + T  +
Sbjct: 203 ISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVK 261

Query: 364 PGITHGVGLVLRVEQQPHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEA 417
            G  +G+ ++L ++Q  +LP+          AG++V +H ++  PF+    F V PG + 
Sbjct: 262 GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQT 321

Query: 418 TISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYL 477
            ++ +E  +  L  P+G C +   G++   +    Y+  AC + C  + +VE C+C   +
Sbjct: 322 FVATQEQRLTYLPPPWGECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-V 376

Query: 478 HPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPS 537
           H +P  A +C+  +H         L  + +++   C +    PC  + +       + PS
Sbjct: 377 H-MPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPS 431

Query: 538 AKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSL 597
             SA +      E+           ++  ++I ++ LNY ++E+   Y V  LL  +G  
Sbjct: 432 KTSAKYL-----EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQ 486

Query: 598 CSLWFGASVLSLLELLELLLD 618
             L+ GAS+L++LEL + + +
Sbjct: 487 MGLFIGASILTILELFDYIYE 507


>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
           b [Homo sapiens]
          Length = 528

 Score =  113 bits (283), Expect = 5e-25
 Identities = 128/557 (22%), Positives = 221/557 (39%), Gaps = 90/557 (16%)

Query: 129 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 183
           F +++T+HG   +       LK   W L  LG+L  L   L +  ER     H+H  V  
Sbjct: 21  FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76

Query: 184 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 243
              V + +   P VTLC+ N  R             F++ + + LY+         L+  
Sbjct: 77  LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118

Query: 244 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 302
             R+E P   +  E +L+ L    +                 +R +      ++++Y   
Sbjct: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158

Query: 303 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 362
                        D  G      +LSC + G  C A  F+      YG CYT +     +
Sbjct: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204

Query: 363 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 410
                 + G  +G+ ++L ++Q  +LP+       S  AGI+V +H ++  PF+    F 
Sbjct: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264

Query: 411 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 470
           V PG +  ++ +E  +  L  P+G C A    ++ +L    SY+  AC + C  + +VE 
Sbjct: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322

Query: 471 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 530
           C+C   +  +P  A YC+  ++             +E  +  C   C  PC  + +    
Sbjct: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376

Query: 531 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 590
              + PS  SA +      +            ++  ++I ++ LNY ++E+   Y +  L
Sbjct: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431

Query: 591 LSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSI 650
           L  +G    L+ GAS+L++LEL +   +     L   G+  + A  S      A     +
Sbjct: 432 LGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDV 491

Query: 651 K---PEASQMPPPAGGT 664
           K   P  S    PAG T
Sbjct: 492 KRHNPCESLRGHPAGMT 508


>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
           [Homo sapiens]
          Length = 512

 Score =  111 bits (277), Expect = 3e-24
 Identities = 73/305 (23%), Positives = 141/305 (46%), Gaps = 28/305 (9%)

Query: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQRPGITHGVGLVLRVEQQ 379
           +L C + G +C  + F T     YG CY  +       + T  + G  +G+ ++L ++Q 
Sbjct: 168 MLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 226

Query: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433
            +LP+          AG++V +H ++  PF+    F V PG +  ++ +E  +  L  P+
Sbjct: 227 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 286

Query: 434 GHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHP 493
           G C +   G++   +    Y+  AC + C  + +VE C+C   +H +P  A +C+  +H 
Sbjct: 287 GECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-VH-MPGDAPFCTPEQHK 340

Query: 494 AWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGL 553
                   L  + +++   C +    PC  + +       + PS  SA +      E+  
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPSKTSAKYL-----EKKF 391

Query: 554 PHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELL 613
                    ++  ++I ++ LNY ++E+   Y V  LL  +G    L+ GAS+L++LEL 
Sbjct: 392 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF 451

Query: 614 ELLLD 618
           + + +
Sbjct: 452 DYIYE 456


>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
           sapiens]
          Length = 531

 Score =  102 bits (254), Expect = 1e-21
 Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)

Query: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 379
           +L C + G  C    F T      G CYT     DG  + T  R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219

Query: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433
            +LP+           GIRV +H +   P +      V PG +  +S ++ ++  L  P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279

Query: 434 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 482
           G C++       E    + L + S      YT   C ++C  + +   C C      +P 
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337

Query: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542
               CS  ++    H       D    +  C   CP PC  + +       R PS  +A 
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391

Query: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602
           +    L       +++   + LA ++I ++ LNY +VE+   Y + +LL  +G    L+ 
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446

Query: 603 GASVLSLLELLELLLD 618
           GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462


>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
           sapiens]
          Length = 549

 Score =  102 bits (254), Expect = 1e-21
 Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)

Query: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 379
           +L C + G  C    F T      G CYT     DG  + T  R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219

Query: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433
            +LP+           GIRV +H +   P +      V PG +  +S ++ ++  L  P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279

Query: 434 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 482
           G C++       E    + L + S      YT   C ++C  + +   C C      +P 
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337

Query: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542
               CS  ++    H       D    +  C   CP PC  + +       R PS  +A 
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391

Query: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602
           +    L       +++   + LA ++I ++ LNY +VE+   Y + +LL  +G    L+ 
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446

Query: 603 GASVLSLLELLELLLD 618
           GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462


>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
           sapiens]
          Length = 543

 Score =  102 bits (254), Expect = 1e-21
 Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)

Query: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 379
           +L C + G  C    F T      G CYT     DG  + T  R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219

Query: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433
            +LP+           GIRV +H +   P +      V PG +  +S ++ ++  L  P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279

Query: 434 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 482
           G C++       E    + L + S      YT   C ++C  + +   C C      +P 
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337

Query: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542
               CS  ++    H       D    +  C   CP PC  + +       R PS  +A 
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391

Query: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602
           +    L       +++   + LA ++I ++ LNY +VE+   Y + +LL  +G    L+ 
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446

Query: 603 GASVLSLLELLELLLD 618
           GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462


>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
           a [Homo sapiens]
          Length = 574

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 107/484 (22%), Positives = 191/484 (39%), Gaps = 87/484 (17%)

Query: 129 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 183
           F +++T+HG   +       LK   W L  LG+L  L   L +  ER     H+H  V  
Sbjct: 21  FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76

Query: 184 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 243
              V + +   P VTLC+ N  R             F++ + + LY+         L+  
Sbjct: 77  LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118

Query: 244 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 302
             R+E P   +  E +L+ L    +                 +R +      ++++Y   
Sbjct: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158

Query: 303 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 362
                        D  G      +LSC + G  C A  F+      YG CYT +     +
Sbjct: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204

Query: 363 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 410
                 + G  +G+ ++L ++Q  +LP+       S  AGI+V +H ++  PF+    F 
Sbjct: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264

Query: 411 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 470
           V PG +  ++ +E  +  L  P+G C A    ++ +L    SY+  AC + C  + +VE 
Sbjct: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322

Query: 471 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 530
           C+C   +  +P  A YC+  ++             +E  +  C   C  PC  + +    
Sbjct: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376

Query: 531 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 590
              + PS  SA +      +            ++  ++I ++ LNY ++E+   Y +  L
Sbjct: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431

Query: 591 LSAM 594
           L  +
Sbjct: 432 LGEL 435


>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
           sapiens]
          Length = 505

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 27/302 (8%)

Query: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGIT----HGVGLVLRVEQQPH 381
           +L C + G  C  + F       YG+C+T +   T Q          G+ L+  V Q+  
Sbjct: 182 LLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240

Query: 382 L--PLLSTL-AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTA 438
              P L  + AGI  ++H     P           G  A ++IR+ +      P+G C  
Sbjct: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300

Query: 439 GGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP---LPAGAEYCSSARHPAW 495
                 ++L + +SY+   CL  C  Q + + C C  +L P   +    +   S   P  
Sbjct: 301 N-----IKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVL 355

Query: 496 GHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPH 555
            H  ++    + TH     S CP  C E  +  +   S +PS K+  +    L      +
Sbjct: 356 DHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL------N 405

Query: 556 QSHRQ-RSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLE 614
           QS +  R +L KI I Y +LNY+  ++    SV +LL+ +G    L+ GAS+++++E++E
Sbjct: 406 QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIE 465

Query: 615 LL 616
            L
Sbjct: 466 YL 467



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 2/76 (2%)

Query: 129 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSV- 187
           F  + + HG   +V +R ++++   W ++ LG++  + WQ+ +    ++  P   ++ V 
Sbjct: 41  FAISTSFHGIHNIVQNR-SKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99

Query: 188 HSERKLLPLVTLCDGN 203
           + E+   P VT C+ N
Sbjct: 100 YVEKMEFPAVTFCNLN 115


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 23/79 (29%)

Query: 45  EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPP 104
           E ++P GG    R+P P  P +P      + RP Q       G  +   PPRPG P  PP
Sbjct: 37  EGRRPQGGNQPQRTPPP--PGKP------EGRPPQG------GNQSQGPPPRPGKPEGPP 82

Query: 105 ---------PPPKEGHQEG 114
                    PPP+ G  EG
Sbjct: 83  PQGGNQSQGPPPRPGKPEG 101



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 29/87 (33%), Positives = 35/87 (40%), Gaps = 18/87 (20%)

Query: 45  EWKQPHGGALTSRSP-------GPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQ-TPPR 96
           E + P GG  +   P       GP  PQ     +G   RP +      QG   +Q  PPR
Sbjct: 58  EGRPPQGGNQSQGPPPRPGKPEGP-PPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPR 116

Query: 97  PGPPSAPP---------PPPKEGHQEG 114
           PG P  PP         PPP+ G  EG
Sbjct: 117 PGKPEGPPPQGGNQSQGPPPRPGKPEG 143



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 28/79 (35%), Positives = 33/79 (41%), Gaps = 23/79 (29%)

Query: 45  EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPP 104
           E + P GG   ++S GP  P RP   +G    P        QG      PPRPG P  PP
Sbjct: 100 EGQPPQGG---NQSQGP--PPRPGKPEG----PPPQGGNQSQGP-----PPRPGKPEGPP 145

Query: 105 ---------PPPKEGHQEG 114
                    PPP+ G  EG
Sbjct: 146 PQGGNQSQGPPPRPGKPEG 164



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 28/84 (33%), Positives = 32/84 (38%), Gaps = 17/84 (20%)

Query: 48  QPHGGALTSRSPGP-------VAPQRPCHLKGWQHRPTQHNAACKQGQAAAQ-TPPRPGP 99
           QP  G   S+ P P         PQ     +G   RP +      QG   +Q  PPRPG 
Sbjct: 102 QPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGK 161

Query: 100 PSAPP---------PPPKEGHQEG 114
           P  PP         PPP  G  EG
Sbjct: 162 PEGPPPQGGNQSQGPPPHPGKPEG 185



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 28/86 (32%), Positives = 34/86 (39%), Gaps = 16/86 (18%)

Query: 45  EWKQPHGGALTSRSPG-PVAPQRPCHLKGWQHR-----PTQHNAACKQGQAAAQ-TPPRP 97
           E   P GG  +   P  P  P+ P    G Q +     P +      QG   +Q  PPRP
Sbjct: 142 EGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRP 201

Query: 98  GPPSAPP---------PPPKEGHQEG 114
           G P  PP         PPP+ G  EG
Sbjct: 202 GKPEGPPPQGGNQSQGPPPRPGKPEG 227



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 26/76 (34%), Positives = 31/76 (40%), Gaps = 15/76 (19%)

Query: 49  PHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQ-TPPRPGPPSAPP--- 104
           PH G    +  GP  PQ     +G   RP +      QG   +Q  PPRPG P  PP   
Sbjct: 178 PHPG----KPEGP-PPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQG 232

Query: 105 ------PPPKEGHQEG 114
                 PPP  G  +G
Sbjct: 233 GNKPQGPPPHPGKPQG 248



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 20/62 (32%), Positives = 22/62 (35%), Gaps = 15/62 (24%)

Query: 49  PHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPK 108
           P  G    R P P  PQ P    G   +P                PP  G P  PPPPP+
Sbjct: 251 PQEGNKPQRPPPPGRPQGPPPPGGNPQQPL---------------PPPAGKPQGPPPPPQ 295

Query: 109 EG 110
            G
Sbjct: 296 GG 297



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 22/78 (28%)

Query: 45  EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPP 104
           E   P GG   ++S GP  P RP   +G    P        QG      PP PG P  PP
Sbjct: 205 EGPPPQGG---NQSQGP--PPRPGKPEG----PPSQGGNKPQGP-----PPHPGKPQGPP 250

Query: 105 P--------PPKEGHQEG 114
           P        PP  G  +G
Sbjct: 251 PQEGNKPQRPPPPGRPQG 268


>gi|5453810 netrin 3 [Homo sapiens]
          Length = 580

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 24/72 (33%), Positives = 31/72 (43%), Gaps = 3/72 (4%)

Query: 51  GGALTSRSPGPVAPQRPCHLKGWQHR---PTQHNAACKQGQAAAQTPPRPGPPSAPPPPP 107
           G    + SPGP AP  PCH +G   R   P   NAA  +   A+ T  RP   +     P
Sbjct: 13  GTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRACDASDP 72

Query: 108 KEGHQEGLVELP 119
           +  H   L+  P
Sbjct: 73  RRAHSPALLTSP 84


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 37.7 bits (86), Expect = 0.037
 Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 59  PGPVAPQRPCHLKGWQHRPTQHNA----ACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEG 114
           P PV  +   H +     P Q+N     +  +  A++Q PP P PPS P PPP      G
Sbjct: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG 327

Query: 115 LVELP 119
             E P
Sbjct: 328 NDETP 332


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 37.7 bits (86), Expect = 0.037
 Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 59  PGPVAPQRPCHLKGWQHRPTQHNA----ACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEG 114
           P PV  +   H +     P Q+N     +  +  A++Q PP P PPS P PPP      G
Sbjct: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG 327

Query: 115 LVELP 119
             E P
Sbjct: 328 NDETP 332


>gi|109689723 abl interactor 2 [Homo sapiens]
          Length = 475

 Score = 37.4 bits (85), Expect = 0.048
 Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 38  STEAWTGEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRP 97
           S  + T    Q +GG   S++P  +AP  P  L+     P     A  Q +  + TPP P
Sbjct: 309 SITSQTSLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLPLMGFVARVQ-ENISDTPPPP 367

Query: 98  GP-------PSAPPPPPKEGHQE 113
            P        S PPPPP E ++E
Sbjct: 368 PPVEEPVFDESPPPPPPPEDYEE 390


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 37.4 bits (85), Expect = 0.048
 Identities = 29/93 (31%), Positives = 33/93 (35%), Gaps = 18/93 (19%)

Query: 33   PPQWLSTEAWTGEWKQP---HGGALTSRSPGPVAPQRP---------CHLKGWQHRPTQH 80
            PP  L T+ + G  + P   H GAL   SPGP  P  P             G Q  P   
Sbjct: 1010 PPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTI 1069

Query: 81   NAACKQGQA------AAQTPPRPGPPSAPPPPP 107
                  GQ+           P PGP   PP PP
Sbjct: 1070 RGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPP 1102



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 9/67 (13%)

Query: 44   GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTP----PRPGP 99
            G   QPH     S++ GP  PQ+P  L+     P Q       G    Q+P    P+PG 
Sbjct: 952  GPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQ-----APGLLPPQSPYPYAPQPGV 1006

Query: 100  PSAPPPP 106
               PPPP
Sbjct: 1007 LGQPPPP 1013



 Score = 30.0 bits (66), Expect = 7.7
 Identities = 13/31 (41%), Positives = 14/31 (45%)

Query: 76  RPTQHNAACKQGQAAAQTPPRPGPPSAPPPP 106
           RP        Q    + T PRP P  APPPP
Sbjct: 878 RPATTTVDSIQAPIPSHTAPRPNPTPAPPPP 908


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 25/77 (32%), Positives = 29/77 (37%), Gaps = 6/77 (7%)

Query: 40  EAWTGEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQH------NAACKQGQAAAQT 93
           EA  G    P     T   P   +P+     K  Q  P++H      NA       A   
Sbjct: 111 EALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGP 170

Query: 94  PPRPGPPSAPPPPPKEG 110
           PP PGPP  P PPP  G
Sbjct: 171 PPPPGPPPPPGPPPPPG 187


>gi|169204928 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 215

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 11/88 (12%)

Query: 33  PPQWLSTEAWTG-------EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACK 85
           P +WL+   W G       E  Q  G      SP  +    P H+     RP    AA  
Sbjct: 72  PSRWLAPGPWRGMGPGAVREGPQVKGART---SPAAIIALLPPHVAA-AARPRAETAAVT 127

Query: 86  QGQAAAQTPPRPGPPSAPPPPPKEGHQE 113
            G  + +  P P PP  PP P + G+ +
Sbjct: 128 DGVTSPRAWPPPPPPPLPPAPTRHGNTD 155


>gi|113423861 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 215

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 11/88 (12%)

Query: 33  PPQWLSTEAWTG-------EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACK 85
           P +WL+   W G       E  Q  G      SP  +    P H+     RP    AA  
Sbjct: 72  PSRWLAPGPWRGMGPGAVREGPQVKGART---SPAAIIALLPPHVAA-AARPRAETAAVT 127

Query: 86  QGQAAAQTPPRPGPPSAPPPPPKEGHQE 113
            G  + +  P P PP  PP P + G+ +
Sbjct: 128 DGVTSPRAWPPPPPPPLPPAPTRHGNTD 155


>gi|113423437 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 215

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 11/88 (12%)

Query: 33  PPQWLSTEAWTG-------EWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACK 85
           P +WL+   W G       E  Q  G      SP  +    P H+     RP    AA  
Sbjct: 72  PSRWLAPGPWRGMGPGAVREGPQVKGART---SPAAIIALLPPHVAA-AARPRAETAAVT 127

Query: 86  QGQAAAQTPPRPGPPSAPPPPPKEGHQE 113
            G  + +  P P PP  PP P + G+ +
Sbjct: 128 DGVTSPRAWPPPPPPPLPPAPTRHGNTD 155


>gi|117938310 sine oculis binding protein homolog [Homo sapiens]
          Length = 873

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 20/66 (30%), Positives = 26/66 (39%)

Query: 44  GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAP 103
           G  +  H     +  PGP AP  P               A  +G  +A+ PP   PP  P
Sbjct: 691 GGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRGAAAEGAKSAEPPPEQPPPPPP 750

Query: 104 PPPPKE 109
           P PPK+
Sbjct: 751 PAPPKK 756


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 23/63 (36%), Positives = 26/63 (41%), Gaps = 10/63 (15%)

Query: 48   QPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQ---TPPRPGPPSAPP 104
            QP G +       P++PQ     KG   RP     A   G   A    TPP P PP  PP
Sbjct: 1531 QPEGSS-------PLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPP 1583

Query: 105  PPP 107
            P P
Sbjct: 1584 PAP 1586


>gi|7657665 zinc finger and BTB domain containing 32 [Homo sapiens]
          Length = 487

 Score = 36.6 bits (83), Expect = 0.082
 Identities = 27/74 (36%), Positives = 31/74 (41%), Gaps = 9/74 (12%)

Query: 37  LSTEAWTGEWKQPHGGALTSRSPGPVA-PQRPCHLKGWQHRPTQHN-----AACKQGQAA 90
           LS  A  G W Q     L S SP P + PQ P  L   +   +        A C   +  
Sbjct: 297 LSLNAPKGLWSQ---NQLASSSPTPGSLPQGPAQLSPGEMEESDQGHTGALATCAGHEDK 353

Query: 91  AQTPPRPGPPSAPP 104
           A  PPRP PP APP
Sbjct: 354 AGCPPRPHPPPAPP 367


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,982,580
Number of Sequences: 37866
Number of extensions: 1911425
Number of successful extensions: 19308
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 253
Number of HSP's that attempted gapping in prelim test: 14945
Number of HSP's gapped (non-prelim): 3688
length of query: 704
length of database: 18,247,518
effective HSP length: 109
effective length of query: 595
effective length of database: 14,120,124
effective search space: 8401473780
effective search space used: 8401473780
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.