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Search of human proteins with 194353959
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194353959 phosphoinositide-3-kinase, class 2 gamma
polypeptide [Homo sapiens]
(1445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 2951 0.0
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 815 0.0
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 735 0.0
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 322 1e-87
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 313 1e-84
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 296 1e-79
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 282 1e-75
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 176 1e-43
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 136 1e-31
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 136 1e-31
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 112 3e-24
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 93 2e-18
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 58 6e-08
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 50 1e-05
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 48 8e-05
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 48 8e-05
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 48 8e-05
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 48 8e-05
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 46 3e-04
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 46 3e-04
gi|31742501 sorting nexin family member 27 [Homo sapiens] 45 4e-04
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 45 5e-04
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b... 45 5e-04
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 43 0.002
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 43 0.002
gi|150170670 piccolo isoform 2 [Homo sapiens] 42 0.006
gi|150378539 piccolo isoform 1 [Homo sapiens] 42 0.006
gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapi... 40 0.021
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 39 0.028
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 39 0.028
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 2951 bits (7650), Expect = 0.0
Identities = 1445/1445 (100%), Positives = 1445/1445 (100%)
Query: 1 MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE 60
MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE
Sbjct: 1 MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE 60
Query: 61 NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT 120
NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT
Sbjct: 61 NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT 120
Query: 121 NKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNS 180
NKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNS
Sbjct: 121 NKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNS 180
Query: 181 SFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQS 240
SFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQS
Sbjct: 181 SFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQS 240
Query: 241 SNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQP 300
SNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQP
Sbjct: 241 SNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQP 300
Query: 301 LHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKS 360
LHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKS
Sbjct: 301 LHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKS 360
Query: 361 VIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL 420
VIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL
Sbjct: 361 VIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL 420
Query: 421 LKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIE 480
LKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIE
Sbjct: 421 LKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIE 480
Query: 481 KVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWV 540
KVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWV
Sbjct: 481 KVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWV 540
Query: 541 HRINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQ 600
HRINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQ
Sbjct: 541 HRINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQ 600
Query: 601 SEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARL 660
SEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARL
Sbjct: 601 SEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARL 660
Query: 661 SQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQ 720
SQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQ
Sbjct: 661 SQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQ 720
Query: 721 PLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLH 780
PLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLH
Sbjct: 721 PLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLH 780
Query: 781 RSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGD 840
RSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGD
Sbjct: 781 RSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGD 840
Query: 841 IGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNAL 900
IGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNAL
Sbjct: 841 IGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNAL 900
Query: 901 PLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLST 960
PLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLST
Sbjct: 901 PLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLST 960
Query: 961 GKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCA 1020
GKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCA
Sbjct: 961 GKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCA 1020
Query: 1021 GWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEY 1080
GWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEY
Sbjct: 1021 GWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEY 1080
Query: 1081 FITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNN 1140
FITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNN
Sbjct: 1081 FITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNN 1140
Query: 1141 LRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLS 1200
LRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLS
Sbjct: 1141 LRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLS 1200
Query: 1201 TTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPE 1260
TTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPE
Sbjct: 1201 TTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPE 1260
Query: 1261 FPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVY 1320
FPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVY
Sbjct: 1261 FPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVY 1320
Query: 1321 LGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRK 1380
LGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRK
Sbjct: 1321 LGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRK 1380
Query: 1381 TKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPL 1440
TKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPL
Sbjct: 1381 TKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPL 1440
Query: 1441 GNSII 1445
GNSII
Sbjct: 1441 GNSII 1445
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 815 bits (2104), Expect = 0.0
Identities = 489/1310 (37%), Positives = 724/1310 (55%), Gaps = 105/1310 (8%)
Query: 233 QLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHI 292
+L EV + + +A+FC+ + +R D F +G +WS T P L + + +
Sbjct: 324 ELFEVSEERDEEVAAFCHMLDILRSGSDIQDY-FLTGYVWSAVTPSPEHLGDEVNLKVTV 382
Query: 293 FIDNSTQPLHFMPCANYLVKDLIAEILHFCTND--QLLPKDHILSVCGSEEFLQNDHCLG 350
D + L F + V LI + L + +D + D +L CG EEFLQN H LG
Sbjct: 383 LCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALG 442
Query: 351 SHKMFQKDKSV---IQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHI---WKVSRQ 404
SH+ Q + I+L L + + L+R +D S LN L+ +SRQ
Sbjct: 443 SHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQ 502
Query: 405 CLLTLIRKYDFHLKYLLKTQEN----VYNIIEEVKKICSVLGCVETKQITDAVNELSLIL 460
L L Y + L + +++ VK IC+ L VET +IT A+N+L
Sbjct: 503 ALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCP 562
Query: 461 QRKGENFYQS-SETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNP 519
R + S + + EKV L+ +I L+ +YCN+F ADFQ VP +
Sbjct: 563 SRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTA-VPGSRKHDLV 621
Query: 520 GLPSH----LSFTVYAAHNIPETWV----------------------------------- 540
H L+FTVYA H IP W
Sbjct: 622 QEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLF 681
Query: 541 ------HRINFPLEIKSLPRESMLTVKLFGIAC----ATNNAN-------LLAWTCLPLF 583
+I FP+++ LPRE++L L+ + +++ AN L W PLF
Sbjct: 682 HLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLF 741
Query: 584 P-KEKSILGSMLFSM--TLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWE--YMKP- 637
++ G L + Q P P + QP V LQIDFP + ++ + P
Sbjct: 742 NFRQVLTCGRKLLGLWPATQENPSARWSAP---NFHQPDSVILQIDFPTSAFDIKFTSPP 798
Query: 638 -DSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLG 696
D R +E + + + QK++ L++ K+ LW R+YC++E SLPLVL
Sbjct: 799 GDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLA 858
Query: 697 SAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEY 756
SAP W+ + +++ +L++WT +ALGLL ++FPDQE+R++AVQ + +L + ELL+Y
Sbjct: 859 SAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDY 918
Query: 757 LPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAAL 816
LPQLVQA+K+E L+SPLV+ LL R++ ++V H +WLLK+ ++ F YQ LLAAL
Sbjct: 919 LPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAAL 978
Query: 817 QFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHL 876
C GK L +EF+++ L+ L + ++V+ A+ RQ +L+ + +++FF +C L
Sbjct: 979 LCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRL 1038
Query: 877 PLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLI 936
PL+P+L +KGI CSYF SNA+PLK++F N +P+G+NI +IFK GDDLRQDML LQ+I
Sbjct: 1039 PLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1098
Query: 937 QVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKK 996
++M IW+QEGLDM+M+I+RC STG+ +G+V+M+P+A TL KI G+ G K+ +
Sbjct: 1099 RIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLAD 1158
Query: 997 WFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFL 1056
W +HN + +YEKA+ NF YSCAG CV T++LG+CDRHNDNIML +GHMFHIDFG+FL
Sbjct: 1159 WLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFL 1218
Query: 1057 GHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNL 1116
GHAQ FG IKRDRAPF+FTS+M Y I G K F DFV+LCC+AYN+IRKH+ L LNL
Sbjct: 1219 GHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1278
Query: 1117 LEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTL 1176
L +ML G+PELS ++DLKYVY+ LRPQDT+ AT++FT+ I+ SL KLN IH L
Sbjct: 1279 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1338
Query: 1177 AQMSAISPAKSTSQTFPQESCLLSTTRSIERATILG----FSKKSSNLYLIQVTHSN-NE 1231
AQM + +F + L ++ I + F +Y+++V N +E
Sbjct: 1339 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1398
Query: 1232 TSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSD---HRRFRDLNHYMEQIL 1288
+ +++FE+F +LH++L+ F S LP FP + + + + RR +LN Y+ ++
Sbjct: 1399 ATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLI 1458
Query: 1289 NVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKP------KVQLVISYEDVK 1342
+ EV D V +FF + +SP +P +V+L ISY++ K
Sbjct: 1459 HAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNK 1518
Query: 1343 LTILVKHMKNIH-LPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEV 1401
L I+V H++ + L DG+ P +V+ YLLP P + +RKTK K +PTYNE++VYD +
Sbjct: 1519 LFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGI 1578
Query: 1402 T--ELQGHVLMLIVKS-----KTVFVGAINIRLCSVPLDKEK--WYPLGN 1442
+LQ L L V S + V +G +NIRL + L +EK W+ LG+
Sbjct: 1579 PKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGS 1628
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 735 bits (1898), Expect = 0.0
Identities = 465/1331 (34%), Positives = 722/1331 (54%), Gaps = 130/1331 (9%)
Query: 227 SIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKT 286
S+ L++ + N +A+FC + K++ ++ + N G + S TA
Sbjct: 363 SLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENA 422
Query: 287 KFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTND--QLLPKDHILSVCGSEEFLQ 344
+ I I+ P+ F + V+ +I + L + +D Q+ ++L VCG EE LQ
Sbjct: 423 SVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQ 482
Query: 345 NDHCLGSHKMFQ---KDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKV 401
N+HCLGSH+ Q K + I+L L L+R E+D + LN+ H++++
Sbjct: 483 NNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNK-----HLYQI 537
Query: 402 SRQCLLTLIR--------KYDFHLKYLLKTQEN---VYNIIEEVKKICSVLGCVETKQIT 450
+ C + R Y ++ L+ + V +I+ V+KICS L VET IT
Sbjct: 538 EKPCKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAIT 597
Query: 451 DAVNEL--SLILQRK----------GENFYQSSETSA---KGLIEKVTTELSTSIYQLIN 495
++V +L ++ L R GE+ +SS + + ++ +L+ +IY L+
Sbjct: 598 ESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLR 657
Query: 496 VYCNSFYADFQPVNVPRCTSYLNPGLPS--HLSFTVYAAHNIPETWVHR----------- 542
++ NS + P + + + + + L FT++AAH I WV
Sbjct: 658 LHANSGRS---PTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLS 714
Query: 543 ------------------------------INFPLEIKSLPRESMLTVKLFGIACATNNA 572
I FP++I LP ES+L + LFGI ++ +
Sbjct: 715 HNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGS 774
Query: 573 N-----------LLAWTCLPLFPKEKSIL-GSMLFSMTLQSEP---PVEMITPGVWDVSQ 617
+ L LPLF ++ + G+ L + S P + G
Sbjct: 775 SPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGY----V 830
Query: 618 PSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKH-----IARLSQKQTPLLLSEE 672
+ LQ+DFP+ ++ + + +RS +++ E +++ + + K + L LS+E
Sbjct: 831 MERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKE 890
Query: 673 KKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSF 732
K +LW R+YC LP +L SAP W +++ +++L +W PL AL LL S F
Sbjct: 891 DKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKF 950
Query: 733 PDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRL 792
DQE+R +AV ++ + +DEL + LPQ VQA+K+E L S LVQ LL R+L +IQ+AH L
Sbjct: 951 ADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNL 1010
Query: 793 YWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQ 852
YWLLK+A ++ F + Y+ +L AL GK L +E K+ KL+++LG + E+V+ AS
Sbjct: 1011 YWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSA 1070
Query: 853 RQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPM 912
RQ VL++ + R++ FFQ N C LPL P+L K ++ +CS+F+SNA+PLK+T +NA+PM
Sbjct: 1071 RQVVLQRSMERVQSFFQK-NKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPM 1129
Query: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPD 972
G+ I+++FK G+DLRQDML LQ+I++MD IWL+EGLD++M+I++CLSTG+D+G+V++VP
Sbjct: 1130 GEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPA 1189
Query: 973 AVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVC 1032
+ TL KI G+ G K+ + +W ++N + +YEKA NF YSCAG CV T++LG+C
Sbjct: 1190 SDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGIC 1249
Query: 1033 DRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHF 1092
DRHNDNIML +GHMFHIDFGKFLGHAQ FG KRDRAPF+ TS+M Y I G K F
Sbjct: 1250 DRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRF 1309
Query: 1093 QDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATS 1152
Q FV+LCC+AYN+IRK + L LNLL +M+ +GLPEL+ IQDLKYV + L+PQ TD EAT
Sbjct: 1310 QLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATI 1369
Query: 1153 HFTKKIKESLECFPVKLNNLIHTLAQM--SAISPAKSTSQTFPQESCLLSTTRSIERATI 1210
FT+ I+ SL K N IH LAQ+ S + +F ++ I+ ++
Sbjct: 1370 FFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSV 1429
Query: 1211 LGFSKK----SSNLYLIQVTHSNN-ETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWW 1265
+ KK +Y++++ E S ++F++F +LH++L F LP FP+
Sbjct: 1430 FTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRM 1489
Query: 1266 HLPFTNSDH---RRFRDLNHYMEQILNVSHEVTNSDCVLSFF---LSEAVQQTVEESSPV 1319
L T+ +R +LN Y++ ++N S +V D V +FF L + + + S+
Sbjct: 1490 VLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADA 1549
Query: 1320 YLGEKFPDK-KPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRR 1378
P + V+L ISY + L I+V H+K++ DG+ P+ +V+ YLLP + +
Sbjct: 1550 GSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK 1609
Query: 1379 RKTKSVPKCTDPTYNEIVVYDEVT-------ELQGHVLMLIVKSKTVFVGAINIRLCSVP 1431
RKTK K +PT+NE++VY + ELQ VL + F+G + + L
Sbjct: 1610 RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFN 1669
Query: 1432 LDKE--KWYPL 1440
L KE KWY L
Sbjct: 1670 LSKETVKWYQL 1680
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 322 bits (826), Expect = 1e-87
Identities = 186/541 (34%), Positives = 315/541 (58%), Gaps = 21/541 (3%)
Query: 637 PDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLG 696
PD E +R E P + K + + L+ E K LW +R+ + P +
Sbjct: 536 PDPEGDRVRAEMP-NQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFS 594
Query: 697 SAPGWDERTVSEMHTIL-RRWTFSQPLEALGL----LTSSFPDQEIRKVAVQQLDNLLND 751
S + V++ + +L RR + Q +GL L +F D+ +R +AVQ+L++L +D
Sbjct: 595 SVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDD 654
Query: 752 ELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKN--AENEAYFKSWY 809
++L YL QLVQAVKFE +S L + LL R L++ ++ H L+W L++ A++ Y + +
Sbjct: 655 DVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFA 714
Query: 810 QKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQ 869
L A L+ C G A+ +F+++ ++I++L + +KS S ++ +V + I +L++ +
Sbjct: 715 VILEAYLRGC-GTAMLHDFTQQVQVIEMLQKVTLDIKSLSA-EKYDVSSQVISQLKQKLE 772
Query: 870 DVNTCHLP------LNPALCIKGIDHDACSYFTSNALPLKITFINANPMG---KNISIIF 920
++ LP +P L + + C S PL + F A+P + I IIF
Sbjct: 773 NLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIF 832
Query: 921 KAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIH 980
K GDDLRQDML+LQ++++M++IW E LD+ ++ Y C+STG G++++V DA T+AKI
Sbjct: 833 KHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ 892
Query: 981 RHS-GLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNI 1039
+ + G G K+ + W + + + ++ A+ F YSCAG+CV TF+LG+ DRHNDNI
Sbjct: 893 QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNI 952
Query: 1040 MLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFI-TEGGKNPQHFQDFVEL 1098
M+T++G++FHIDFG LG+ ++F GI ++R PF+ T + + + T G K HFQ F ++
Sbjct: 953 MITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDI 1012
Query: 1099 CCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKI 1158
C +AY +R H+ LL+ L MML G+P+L+ +D++Y+ + L + +A +F +I
Sbjct: 1013 CVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQI 1072
Query: 1159 K 1159
+
Sbjct: 1073 E 1073
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 313 bits (801), Expect = 1e-84
Identities = 231/756 (30%), Positives = 375/756 (49%), Gaps = 53/756 (7%)
Query: 468 YQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSF 527
Y + ETS K L + + L I L Y N D + V T + G P +
Sbjct: 317 YMNGETSTKSLWV-INSALRIKI--LCATYVNVNIRDIDKIYVR--TGIYHGGEPLCDNV 371
Query: 528 TVYAAHNIPETWVHRINFPLEIKSLPRESMLTVKLFGIAC---ATNNANLLAWTCLPLFP 584
W +N+ + I LPR + L + + + A LAW + LF
Sbjct: 372 NTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFD 431
Query: 585 KEKSIL-GSMLFSMTLQSEPPVEMITPGVWDVSQPSPVT--LQIDFPATGWEYMKPDSE- 640
+++ G M ++ +++ P S P+ T L+++F PD
Sbjct: 432 YTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSV 491
Query: 641 ----------------------ENRSNLEEPLKECIKHIARLSQKQTPLL-LSEEKKRYL 677
NR + L+E K + + PL ++E++K +L
Sbjct: 492 IEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFL 551
Query: 678 WFYRFYCNNENCSLPLVLGSAPGWDERT-VSEMHTILRRWTFSQPLEALGLLTSSFPDQE 736
W +R YC LP +L S W+ R V++M+ +++ W +P +A+ LL ++PD
Sbjct: 552 WSHRHYCVTIPEILPKLLLSVK-WNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPM 610
Query: 737 IRKVAVQQLDNLLNDELL-EYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWL 795
+R AV+ L+ L D+ L +YL QLVQ +K+E L++ LV+ LL ++L + ++ H +W
Sbjct: 611 VRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWH 670
Query: 796 LKNAENEAYFKSWYQKLLAALQFCAG---KALNDEFSKEQKLIKILGDIGERVKSASDHQ 852
LK+ + + LL + G K LN + +KLI + + + K +
Sbjct: 671 LKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKV 730
Query: 853 RQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPM 912
+ + L +++ R +F + PLNPA + + + C +S PL + + N + M
Sbjct: 731 QMKFLVEQMRR-PDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIM 789
Query: 913 GK----NISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQ 968
+ N IIFK GDDLRQDML LQ+I++M+NIW +GLD++M+ Y CLS G GL++
Sbjct: 790 SELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIE 849
Query: 969 MVPDAVTLAKIHRHSGLIGPLKEN--TIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVT 1026
+V ++ T+ +I GL G L+ N T+ +W N + Y+ A+ F SCAG+CV T
Sbjct: 850 VVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVAT 908
Query: 1027 FILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086
FILG+ DRHN NIM+ G +FHIDFG FL H + G KR+R PF+ T + I++G
Sbjct: 909 FILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGA 968
Query: 1087 K---NPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRP 1143
+ + F+ F E+C +AY IR+H+ L +NL MML +G+PEL D+ Y+ L
Sbjct: 969 QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLAL 1028
Query: 1144 QDTDLEATSHFTKKIKESLE-CFPVKLNNLIHTLAQ 1178
T+ EA +F K++ ++ + K++ + HT+ Q
Sbjct: 1029 DKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 296 bits (757), Expect = 1e-79
Identities = 215/675 (31%), Positives = 333/675 (49%), Gaps = 40/675 (5%)
Query: 539 WVHRINFPLEIKSLPRESMLTVKLFGIACATNNANL-----------LAWTCLPLFP-KE 586
W R+ F + I LPR + L L+ + A +AW L LF K+
Sbjct: 371 WKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKD 430
Query: 587 KSILGSM-LFSMTLQSEPPVEMITPGVWDVSQP---SPVTLQIDFPATGWEYMKPDSEEN 642
+ G L+ + E++ P S P S L I P + + E
Sbjct: 431 QLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEK 490
Query: 643 RSNLEEPLKECIKHIARLSQKQTPLLLS--------EEKKRYLWFYRFYCNNENCSLPLV 694
L EC+ H+ Q Q +L E +K +W R
Sbjct: 491 ILELGRH-SECV-HVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALAR 548
Query: 695 LGSAPGWDERT-VSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDEL 753
L W++ V++M +L W L AL LL SFPD + A++ L L +DEL
Sbjct: 549 LLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDEL 608
Query: 754 LEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLL 813
+YL QLVQ +K+E L+ L + LL R+L + ++ H L+W L++ + + +L
Sbjct: 609 FQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLIL 668
Query: 814 AALQFCAGKALNDEFSKEQ----KLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQ 869
A +C G + + +Q +K L D + + + + L R E + +
Sbjct: 669 EA--YCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLE 726
Query: 870 DVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANP-MGKNISIIFKAGDDLRQ 928
++ PL+P+ + + + C++ S PL I + N G ++ IIFK GDDLRQ
Sbjct: 727 ALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQ 786
Query: 929 DMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGP 988
DML LQ+IQ+MD +W QEGLD++M Y CL TG GL+++V + T+A I + +
Sbjct: 787 DMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAA 846
Query: 989 ---LKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSG 1045
++ + W N +A ++A+ F SCAG+CV T++LG+ DRH+DNIM+ +SG
Sbjct: 847 TAAFNKDALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESG 905
Query: 1046 HMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG-GKNPQHFQDFVELCCRAYN 1104
+FHIDFG FLG+ +T GI R+R PFI T + + I +G N + F+ F C RAY
Sbjct: 906 QLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYT 965
Query: 1105 IIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESL-E 1163
I+R+H L L+L +M AGLPELS +D++Y+ ++L T+ EA HF K E+L E
Sbjct: 966 ILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRE 1025
Query: 1164 CFPVKLNNLIHTLAQ 1178
+ K+N L H +++
Sbjct: 1026 SWKTKVNWLAHNVSK 1040
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 282 bits (722), Expect = 1e-75
Identities = 208/703 (29%), Positives = 347/703 (49%), Gaps = 63/703 (8%)
Query: 498 CNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESM 557
C + YA V + T +NP + + + P WV+ + F
Sbjct: 401 CFAVYAVLDKVKTKKSTKTINPS--KYQTIRKAGKVHYPVAWVNTMVFD----------- 447
Query: 558 LTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSM-TLQSEPPVEMITPGVWDVS 616
F T + L +W+ FP E L ML M T+Q+ P E T
Sbjct: 448 -----FKGQLRTGDIILHSWSS---FPDE---LEEMLNPMGTVQTNPYTENAT------- 489
Query: 617 QPSPVTLQIDFPATGWE--YMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLL------ 668
L + FP + Y P + E + +R +K P+L
Sbjct: 490 -----ALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDR 544
Query: 669 -----LSEEKKRYLWFYRFYCNNE-NCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPL 722
L E + +W R C SLP +L S V+++ +L+ W P
Sbjct: 545 DPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPR 604
Query: 723 EALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRS 782
EAL LL ++PDQ +R+ AV L + ++EL +YL QLVQ +K+E L+ L + LL R+
Sbjct: 605 EALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERA 664
Query: 783 LQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDE-FSKEQKLIKILGDI 841
L + ++ L+W L++ + + +L A +C G + + SK+ + + L +
Sbjct: 665 LGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEA--YCRGSVGHMKVLSKQVEALNKLKTL 722
Query: 842 GERVKSASDHQRQEVLKKEIG---RLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSN 898
+K + + K+ + + + + ++ PLNP + + + + C Y S
Sbjct: 723 NSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSK 782
Query: 899 ALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCL 958
PL + + N ++ +IFK GDDLRQDML LQ++++MD +W + GLD++M+ Y CL
Sbjct: 783 MKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCL 842
Query: 959 STGKDQGLVQMVPDAVTLAKIHRHSGLIGP---LKENTIKKWFSQHNHLKADYEKALRNF 1015
+TG GL+++V + T+A I +S + ++ + W ++N D ++A+ F
Sbjct: 843 ATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNS-GDDLDRAIEEF 901
Query: 1016 FYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFT 1075
SCAG+CV +++LG+ DRH+DNIM+ K+G +FHIDFG LG+ ++ GIKR+R PFI T
Sbjct: 902 TLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILT 961
Query: 1076 SEMEYFITEGGK-NPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDL 1134
+ + I +G N + F F + C AY I+R+H L + L +ML AGLPEL+ ++D+
Sbjct: 962 YDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDI 1021
Query: 1135 KYVYNNLRPQDTDLEATSHFTKKIKESL-ECFPVKLNNLIHTL 1176
+Y+ ++L ++ EA F +K E+L E + K+N + HT+
Sbjct: 1022 QYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 176 bits (446), Expect = 1e-43
Identities = 127/430 (29%), Positives = 218/430 (50%), Gaps = 36/430 (8%)
Query: 769 NLESPLVQLLLHRSLQSIQVAHRLYWLL----KNAENEAYFKSWYQKLLAALQFCAGKAL 824
NLE L L+ R+ ++ +A+ LYW + ++ + + ++ L ++ + L
Sbjct: 470 NLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALL 529
Query: 825 NDEFS---------KEQKLIKILGDIGERVKSASDHQRQ--EVLKKEIGRLEEF-FQDVN 872
+ S +Q + L + + V+ S ++++ E L+ +G E+ DV
Sbjct: 530 KGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVE 589
Query: 873 TCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLV 932
LPL P + I+GI + + F S +P ++ F + G +IFK GDDLRQD L+
Sbjct: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLRQDQLI 647
Query: 933 LQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKEN 992
LQ+I +MD + +E LD+++ Y+ L+T G +Q + +V +A++ G I +N
Sbjct: 648 LQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVLDTEGSI----QN 702
Query: 993 TIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDF 1052
+K+ N + + + SCAG+CV+T+ILGV DRH DN++LTK+G +FHIDF
Sbjct: 703 FFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
Query: 1053 GKFLGHAQTFGGIKRDRAPFIFTSEMEYFITE--GGKNPQHFQDFVELCCRAYNIIRKHS 1110
G LG RD P ++ + E GG + +Q+F + C A+ +R++S
Sbjct: 763 GYILG---------RDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYS 813
Query: 1111 QLLLNLLEMMLYAGLPELSGIQD--LKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVK 1168
L+LNL +M+ A +P+++ D +K V + R +D EA + I ES+
Sbjct: 814 NLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAA 873
Query: 1169 LNNLIHTLAQ 1178
+ IH AQ
Sbjct: 874 VVEQIHKFAQ 883
Score = 52.0 bits (123), Expect = 4e-06
Identities = 31/100 (31%), Positives = 56/100 (56%), Gaps = 2/100 (2%)
Query: 669 LSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWD-ERTVSEMHTILRRWTFSQPLEALGL 727
L+ E++ +W +R+Y N+ +L L WD + + +L +W ++L L
Sbjct: 308 LTYEEQDLVWKFRYYLTNQEKALTKFL-KCVNWDLPQEAKQALELLGKWKPMDVEDSLEL 366
Query: 728 LTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFE 767
L+S + + +R+ AV +L +++LL YL QLVQA+K+E
Sbjct: 367 LSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYE 406
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 136 bits (343), Expect = 1e-31
Identities = 123/490 (25%), Positives = 220/490 (44%), Gaps = 59/490 (12%)
Query: 716 WTFSQPLEALGLLTSSFPDQEIR-KVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPL 774
W + P L +S +P + + V+ L + D +L Y+PQ+VQA++++ +
Sbjct: 364 WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYD--KMGYV 421
Query: 775 VQLLLHRSLQSIQVAHRLYWLLKN---AENEAYFKS-----WYQKLLAALQFCAGKALND 826
+ +L + +S +AH+ W +K + E + K +L+ + D
Sbjct: 422 REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 481
Query: 827 EFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKG 886
+ +E + ++ +K ++ K + L E C+LP NP +
Sbjct: 482 FYQREFDFFNKITNVSAIIKPYPKGDERK--KACLSALSEVKVQPG-CYLPSNPEAIVLD 538
Query: 887 IDHDACSYFTSNA-----LPLKITFINANPM---------------------GKNIS--- 917
ID+ + + S A K+ + + G+ IS
Sbjct: 539 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 598
Query: 918 IIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLA 977
IFK GDD RQDML LQ+I + NI+ GLD+ + YR ++T G+++ +PD +
Sbjct: 599 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658
Query: 978 KIHRHSGLIGPLKENTIKKWFSQH--NHLKADYEKALRNFFYSCAGWCVVTFILGVCDRH 1035
++ R + + + +F++ + +++A NF S A + ++ F+L + DRH
Sbjct: 659 QLGRQT-------DFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 711
Query: 1036 NDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDF 1095
N NIML K GH+ HIDFG F+ + G + + P I ++ I G F+ F
Sbjct: 712 NGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKWF 768
Query: 1096 VELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFT 1155
+E+C R Y +R + +++L+ +ML GLP G Q +K + + P T+ EA +
Sbjct: 769 MEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIM 827
Query: 1156 KKIKESLECF 1165
K I+ CF
Sbjct: 828 KVIQ---SCF 834
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 136 bits (343), Expect = 1e-31
Identities = 123/490 (25%), Positives = 220/490 (44%), Gaps = 59/490 (12%)
Query: 716 WTFSQPLEALGLLTSSFPDQEIR-KVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPL 774
W + P L +S +P + + V+ L + D +L Y+PQ+VQA++++ +
Sbjct: 1554 WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYD--KMGYV 1611
Query: 775 VQLLLHRSLQSIQVAHRLYWLLKN---AENEAYFKS-----WYQKLLAALQFCAGKALND 826
+ +L + +S +AH+ W +K + E + K +L+ + D
Sbjct: 1612 REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 1671
Query: 827 EFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKG 886
+ +E + ++ +K ++ K + L E C+LP NP +
Sbjct: 1672 FYQREFDFFNKITNVSAIIKPYPKGDERK--KACLSALSEVKVQPG-CYLPSNPEAIVLD 1728
Query: 887 IDHDACSYFTSNA-----LPLKITFINANPM---------------------GKNIS--- 917
ID+ + + S A K+ + + G+ IS
Sbjct: 1729 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 1788
Query: 918 IIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLA 977
IFK GDD RQDML LQ+I + NI+ GLD+ + YR ++T G+++ +PD +
Sbjct: 1789 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 1848
Query: 978 KIHRHSGLIGPLKENTIKKWFSQH--NHLKADYEKALRNFFYSCAGWCVVTFILGVCDRH 1035
++ R + + + +F++ + +++A NF S A + ++ F+L + DRH
Sbjct: 1849 QLGRQT-------DFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 1901
Query: 1036 NDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDF 1095
N NIML K GH+ HIDFG F+ + G + + P I ++ I G F+ F
Sbjct: 1902 NGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKWF 1958
Query: 1096 VELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFT 1155
+E+C R Y +R + +++L+ +ML GLP G Q +K + + P T+ EA +
Sbjct: 1959 MEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIM 2017
Query: 1156 KKIKESLECF 1165
K I+ CF
Sbjct: 2018 KVIQ---SCF 2024
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 112 bits (280), Expect = 3e-24
Identities = 65/211 (30%), Positives = 111/211 (52%), Gaps = 11/211 (5%)
Query: 911 PMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMV 970
P + +S+I K GDDLRQ++L Q+++ + +IW QE + + + Y+ L D G+++ V
Sbjct: 566 PNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPV 625
Query: 971 PDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKAD-YEKALRNFFYSCAGWCVVTFIL 1029
+AV++ ++ + S L + + + +H + + A RNF SCAG+C+V ++L
Sbjct: 626 VNAVSIHQVKKQSQL------SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLL 679
Query: 1030 GVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNP 1089
V DRHN NI+L GH+ HIDFG L + G + F E+ GG +
Sbjct: 680 QVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETS----AFKLTTEFVDVMGGLDG 735
Query: 1090 QHFQDFVELCCRAYNIIRKHSQLLLNLLEMM 1120
F + L + RKH ++ ++E+M
Sbjct: 736 DMFNYYKMLMLQGLIAARKHMDKVVQIVEIM 766
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
3 alpha [Homo sapiens]
Length = 286
Score = 92.8 bits (229), Expect = 2e-18
Identities = 50/137 (36%), Positives = 80/137 (58%), Gaps = 9/137 (6%)
Query: 919 IFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAK 978
IFK GDD RQDML LQ+I + NI+ GLD+ + YR ++T G+++ +PD + +
Sbjct: 54 IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
Query: 979 IHRHSGLIGPLKENTIKKWFSQH--NHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHN 1036
+ R + + + +F++ + +++A NF S A + ++ F+L + DRHN
Sbjct: 114 LGRQT-------DFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHN 166
Query: 1037 DNIMLTKSGHMFHIDFG 1053
NIML K GH+ HIDFG
Sbjct: 167 GNIMLDKKGHIIHIDFG 183
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 58.2 bits (139), Expect = 6e-08
Identities = 69/288 (23%), Positives = 117/288 (40%), Gaps = 52/288 (18%)
Query: 877 PLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLI 936
P P + I+ I + TS P K+T + +N G + K +DLRQD V+QL
Sbjct: 2146 PNQPIIRIQSIA-PSLQVITSKQRPRKLTLMGSN--GHEFVFLLKGHEDLRQDERVMQLF 2202
Query: 937 QVMDNIW------LQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRH----SGLI 986
+++ + L++ L +Q LST + GL+ VP TL + R ++
Sbjct: 2203 GLVNTLLANDPTSLRKNLSIQRYAVIPLST--NSGLIGWVPHCDTLHALIRDYREKKKIL 2260
Query: 987 GPLKENTIKKWFSQHNHLKA-----------------DYEKAL--------------RNF 1015
++ + + ++HL D K L N+
Sbjct: 2261 LNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNY 2320
Query: 1016 FYSCAGWCVVTFILGVCDRHNDNIMLTK-SGHMFHIDFGKFLGHAQTFGGIKRDRAPFIF 1074
S A +V +ILG+ DRH N+ML + SG + HIDFG A T R++ P
Sbjct: 2321 TRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMT-----REKFPEKI 2375
Query: 1075 TSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLY 1122
+ +T + ++ C ++R+H ++ +LE +Y
Sbjct: 2376 PFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVY 2423
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 50.4 bits (119), Expect = 1e-05
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 13/124 (10%)
Query: 1330 PKVQLVISYEDVKLTILVKHMKNIHLP---DGSAPSAHVEFYLLPYPSEVRRRKTKSVPK 1386
P+VQ+ + ++ V ++V + LP DG + +V+ Y LP S+ +R+TK+V K
Sbjct: 745 PRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 804
Query: 1387 CTDPTYNEIVVYDEVTELQGHVLML---------IVKSKTVFVGAINIRLCSVPLDKE-K 1436
+P +N+ +Y V + ML + + ++ F+G I I L + LD E
Sbjct: 805 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 864
Query: 1437 WYPL 1440
WY L
Sbjct: 865 WYKL 868
Score = 34.3 bits (77), Expect = 0.89
Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 1361 PSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIV 1413
P+ +V+ YLL + ++KTK K +P Y +++ ++E QG VL +IV
Sbjct: 1230 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE--SPQGKVLQIIV 1280
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 47.8 bits (112), Expect = 8e-05
Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 54/284 (19%)
Query: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLD-----MQMIIYRCLSTGKDQGLV 967
GK + K DDLRQD ++ Q+ Q M N LQ + + + Y+ + + G++
Sbjct: 1361 GKERRQLVKGRDDLRQDAVMQQVFQ-MCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 1419
Query: 968 QMVPDAVTLAK--IHRHSGLIGPLKENTI-------------KKWFSQHNHLKAD----Y 1008
+ V + + ++ G + N KK F + + D +
Sbjct: 1420 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 1479
Query: 1009 EKALRNF----FYSCAGW--------------CVVTFILGVCDRHNDNIMLT-KSGHMFH 1049
+ R F F A W +V +ILG+ DRH NI++ +S + H
Sbjct: 1480 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 1539
Query: 1050 IDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCC-RAYNIIRK 1108
ID G + + PF T ++ G + CC + ++R
Sbjct: 1540 IDLGVAFEQGKILP--TPETVPFRLTRDI-----VDGMGITGVEGVFRRCCEKTMEVMRN 1592
Query: 1109 HSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQD-TDLEAT 1151
+ LL ++E++LY L + + + LK +Y RP+D T+L T
Sbjct: 1593 SQETLLTIVEVLLYDPLFDWT-MNPLKALYLQQRPEDETELHPT 1635
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 47.8 bits (112), Expect = 8e-05
Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 54/284 (19%)
Query: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLD-----MQMIIYRCLSTGKDQGLV 967
GK + K DDLRQD ++ Q+ Q M N LQ + + + Y+ + + G++
Sbjct: 2709 GKERRQLVKGRDDLRQDAVMQQVFQ-MCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2767
Query: 968 QMVPDAVTLAK--IHRHSGLIGPLKENTI-------------KKWFSQHNHLKAD----Y 1008
+ V + + ++ G + N KK F + + D +
Sbjct: 2768 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2827
Query: 1009 EKALRNF----FYSCAGW--------------CVVTFILGVCDRHNDNIMLT-KSGHMFH 1049
+ R F F A W +V +ILG+ DRH NI++ +S + H
Sbjct: 2828 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2887
Query: 1050 IDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCC-RAYNIIRK 1108
ID G + + PF T ++ G + CC + ++R
Sbjct: 2888 IDLGVAFEQGKILP--TPETVPFRLTRDI-----VDGMGITGVEGVFRRCCEKTMEVMRN 2940
Query: 1109 HSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQD-TDLEAT 1151
+ LL ++E++LY L + + + LK +Y RP+D T+L T
Sbjct: 2941 SQETLLTIVEVLLYDPLFDWT-MNPLKALYLQQRPEDETELHPT 2983
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 47.8 bits (112), Expect = 8e-05
Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 54/284 (19%)
Query: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLD-----MQMIIYRCLSTGKDQGLV 967
GK + K DDLRQD ++ Q+ Q M N LQ + + + Y+ + + G++
Sbjct: 2587 GKERRQLVKGRDDLRQDAVMQQVFQ-MCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2645
Query: 968 QMVPDAVTLAK--IHRHSGLIGPLKENTI-------------KKWFSQHNHLKAD----Y 1008
+ V + + ++ G + N KK F + + D +
Sbjct: 2646 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2705
Query: 1009 EKALRNF----FYSCAGW--------------CVVTFILGVCDRHNDNIMLT-KSGHMFH 1049
+ R F F A W +V +ILG+ DRH NI++ +S + H
Sbjct: 2706 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2765
Query: 1050 IDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCC-RAYNIIRK 1108
ID G + + PF T ++ G + CC + ++R
Sbjct: 2766 IDLGVAFEQGKILP--TPETVPFRLTRDI-----VDGMGITGVEGVFRRCCEKTMEVMRN 2818
Query: 1109 HSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQD-TDLEAT 1151
+ LL ++E++LY L + + + LK +Y RP+D T+L T
Sbjct: 2819 SQETLLTIVEVLLYDPLFDWT-MNPLKALYLQQRPEDETELHPT 2861
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 47.8 bits (112), Expect = 8e-05
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 13/116 (11%)
Query: 1338 YEDVKLTILVKHMKNIHLP---DGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNE 1394
Y+ V ++V ++ LP DG + +V+ Y LP S+ +R+TK+V K +P +N+
Sbjct: 752 YDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
Query: 1395 IVVYDEVTELQGHVLML---------IVKSKTVFVGAINIRLCSVPLDKE-KWYPL 1440
VY V ML + + ++ F+G I I L + LD E WY L
Sbjct: 812 TFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKL 867
Score = 39.7 bits (91), Expect = 0.021
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 10/90 (11%)
Query: 1359 SAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIV----- 1413
S P+ +V+ YLL + + ++KT+ K DP Y + +V+DE QG VL +IV
Sbjct: 1571 STPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDE--SPQGKVLQVIVWGDYG 1628
Query: 1414 -KSKTVFVGAINIRLCSVPLDKE--KWYPL 1440
F+G I L + L WY L
Sbjct: 1629 RMDHKCFMGVAQILLEELDLSSMVIGWYKL 1658
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 45.8 bits (107), Expect = 3e-04
Identities = 49/171 (28%), Positives = 71/171 (41%), Gaps = 27/171 (15%)
Query: 919 IFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIY-RCLSTGKDQGLVQMVPDAVTLA 977
+ K G+DLRQD V QL QVM+ I Q+ Q + R S P
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3810
Query: 978 KIHRHSG----------LIGPLKENTIKKWFSQHNHLKADYEK--------------ALR 1013
+ + SG G + T+ + + + + AD K ALR
Sbjct: 3811 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALR 3870
Query: 1014 NFFYSC-AGWCVVTFILGVCDRHNDNIMLT-KSGHMFHIDFGKFLGHAQTF 1062
+ F S A C+ +ILG+ DRH +N M+ ++G + IDFG G A F
Sbjct: 3871 SHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 3921
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 45.8 bits (107), Expect = 3e-04
Identities = 49/171 (28%), Positives = 71/171 (41%), Gaps = 27/171 (15%)
Query: 919 IFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIY-RCLSTGKDQGLVQMVPDAVTLA 977
+ K G+DLRQD V QL QVM+ I Q+ Q + R S P
Sbjct: 3750 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3809
Query: 978 KIHRHSG----------LIGPLKENTIKKWFSQHNHLKADYEK--------------ALR 1013
+ + SG G + T+ + + + + AD K ALR
Sbjct: 3810 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALR 3869
Query: 1014 NFFYSC-AGWCVVTFILGVCDRHNDNIMLT-KSGHMFHIDFGKFLGHAQTF 1062
+ F S A C+ +ILG+ DRH +N M+ ++G + IDFG G A F
Sbjct: 3870 SHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQF 3920
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 45.4 bits (106), Expect = 4e-04
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 8/97 (8%)
Query: 1234 LTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHR---RFRDLNHYMEQILNV 1290
L K + +F+ LH L+++FA+ T P P W PF+ S+ + R R L Y+E++ ++
Sbjct: 192 LCSKRYREFAILHQNLKREFANFTFPRLPGKW--PFSLSEQQLDARRRGLEEYLEKVCSI 249
Query: 1291 SHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPD 1327
V ++ FLSE+ + S V L PD
Sbjct: 250 --RVIGESDIMQEFLSES-DENYNGVSDVELRVALPD 283
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 45.1 bits (105), Expect = 5e-04
Identities = 52/202 (25%), Positives = 80/202 (39%), Gaps = 58/202 (28%)
Query: 919 IFKAGDDLRQDMLVLQLIQVMDNIWLQEGL----DMQMIIYRCLSTGKDQGLVQMVPDAV 974
+ K G+DLRQD V QL QVM+ I Q+ +Q+ Y + GL++ + + V
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTV 3810
Query: 975 TLAK----------------------------IHRHSG----------LIGPLKENTIKK 996
TL + + SG G + T+
Sbjct: 3811 TLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTS 3870
Query: 997 WFSQHNHLKADYEK--------------ALRNFFYSC-AGWCVVTFILGVCDRHNDNIML 1041
+ + + + AD K ALR+ F S A C+ +ILG+ DRH +N M+
Sbjct: 3871 FRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV 3930
Query: 1042 T-KSGHMFHIDFGKFLGHAQTF 1062
++G + IDFG G A F
Sbjct: 3931 AMETGGVIGIDFGHAFGSATQF 3952
>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
[Homo sapiens]
Length = 1163
Score = 45.1 bits (105), Expect = 5e-04
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 10/94 (10%)
Query: 1357 DGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLML----- 1411
DG + +V+ Y LP S+ +R+TK+V K +P +N+ +Y V + ML
Sbjct: 567 DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW 626
Query: 1412 ----IVKSKTVFVGAINIRLCSVPLDKE-KWYPL 1440
+ + ++ F+G I I L + LD E WY L
Sbjct: 627 DQARVREEESEFLGEILIELETALLDDEPHWYKL 660
Score = 34.3 bits (77), Expect = 0.89
Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 1361 PSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIV 1413
P+ +V+ YLL + ++KTK K +P Y +++ ++E QG VL +IV
Sbjct: 1044 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE--SPQGKVLQIIV 1094
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 43.1 bits (100), Expect = 0.002
Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 48/284 (16%)
Query: 884 IKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIW 943
I G D D S P KI+ ++ GK ++ K DDLR+D +++ +++
Sbjct: 2293 IAGFD-DMVEILASLQKPKKISLKGSD--GKFYIMMCKPKDDLRKDCRLMEFNSLINKCL 2349
Query: 944 LQEG----LDMQMIIYRCLSTGKDQGLVQMVPDAV----TLAKIHRHSGLIGPLKENT-- 993
++ ++ + Y + + G+++ V + L K+++ G+ KE
Sbjct: 2350 RKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC 2409
Query: 994 -------------IKKWFSQHNHLKADYEKALRNF------FYSCAGWC-------VVTF 1027
+ + F H +E LR F + S + +C +V +
Sbjct: 2410 MLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGY 2469
Query: 1028 ILGVCDRHNDNIML-TKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086
ILG+ DRH +NI+ + +G H+DF +TF + PF T M G
Sbjct: 2470 ILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNM-----VNG 2522
Query: 1087 KNPQHFQDFVELCCR-AYNIIRKHSQLLLNLLEMMLYAGLPELS 1129
P + C ++R + L+++L+ L+ L E S
Sbjct: 2523 MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWS 2566
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 43.1 bits (100), Expect = 0.002
Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 48/284 (16%)
Query: 884 IKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIW 943
I G D D S P KI+ ++ GK ++ K DDLR+D +++ +++
Sbjct: 35 IAGFD-DMVEILASLQKPKKISLKGSD--GKFYIMMCKPKDDLRKDCRLMEFNSLINKCL 91
Query: 944 LQEG----LDMQMIIYRCLSTGKDQGLVQMVPDAV----TLAKIHRHSGLIGPLKENT-- 993
++ ++ + Y + + G+++ V + L K+++ G+ KE
Sbjct: 92 RKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC 151
Query: 994 -------------IKKWFSQHNHLKADYEKALRNF------FYSCAGWC-------VVTF 1027
+ + F H +E LR F + S + +C +V +
Sbjct: 152 MLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGY 211
Query: 1028 ILGVCDRHNDNIML-TKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086
ILG+ DRH +NI+ + +G H+DF +TF + PF T M G
Sbjct: 212 ILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNM-----VNG 264
Query: 1087 KNPQHFQDFVELCCR-AYNIIRKHSQLLLNLLEMMLYAGLPELS 1129
P + C ++R + L+++L+ L+ L E S
Sbjct: 265 MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWS 308
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 41.6 bits (96), Expect = 0.006
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 19/129 (14%)
Query: 1331 KVQLVISYEDVKLTILVKHMKNIHLPDGSAPS-AHVEFYLLPYPSEVR---------RRK 1380
++QL I+Y+ L I + +N+ D + S V+ YLLP +V +R+
Sbjct: 4697 EIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRR 4756
Query: 1381 TKSVPKCTDPTYNEIVVYDEVT--ELQGHVLMLIV-----KSKTVFVGAINIRLCSVP-L 1432
TK V K +P +N+ V+Y ++ +L+ L + V S F+G + I L S L
Sbjct: 4757 TKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHL 4816
Query: 1433 DK-EKWYPL 1440
D +WYPL
Sbjct: 4817 DNTPRWYPL 4825
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 41.6 bits (96), Expect = 0.006
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 19/129 (14%)
Query: 1331 KVQLVISYEDVKLTILVKHMKNIHLPDGSAPS-AHVEFYLLPYPSEVR---------RRK 1380
++QL I+Y+ L I + +N+ D + S V+ YLLP +V +R+
Sbjct: 4697 EIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRR 4756
Query: 1381 TKSVPKCTDPTYNEIVVYDEVT--ELQGHVLMLIV-----KSKTVFVGAINIRLCSVP-L 1432
TK V K +P +N+ V+Y ++ +L+ L + V S F+G + I L S L
Sbjct: 4757 TKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHL 4816
Query: 1433 DK-EKWYPL 1440
D +WYPL
Sbjct: 4817 DNTPRWYPL 4825
>gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapiens]
Length = 308
Score = 39.7 bits (91), Expect = 0.021
Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 10/90 (11%)
Query: 1359 SAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIV----- 1413
S P+ +++ YLL + + ++KTK K DP Y + +++DE QG VL +IV
Sbjct: 189 SLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGP--QGKVLQVIVWGDYG 246
Query: 1414 -KSKTVFVGAINIRLCSVPLDK--EKWYPL 1440
F+G I L + L WY L
Sbjct: 247 RMDHKCFMGMAQIMLDELDLSAAVTGWYKL 276
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 39.3 bits (90), Expect = 0.028
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 1329 KPKVQLVISY-EDVK-LTILVKHMKNIHLPDGSAPSA--HVEFYLLPYPSEVRRRKTKSV 1384
K +Q I Y E +K L + V K++ D + +V+ YLLP ++ ++KT V
Sbjct: 71 KGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVV 130
Query: 1385 PKCTDPTYNEIVVYD-EVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKW 1437
K +P YNEI+ Y E L+ L L + + F N L V LD E W
Sbjct: 131 KKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETW 182
Score = 38.5 bits (88), Expect = 0.047
Identities = 21/55 (38%), Positives = 33/55 (60%)
Query: 1345 ILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYD 1399
I VK ++ L GS ++ V+ +LP S R+KT++V K T+P +N +VYD
Sbjct: 238 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYD 292
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 39.3 bits (90), Expect = 0.028
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 1329 KPKVQLVISY-EDVK-LTILVKHMKNIHLPDGSAPSA--HVEFYLLPYPSEVRRRKTKSV 1384
K +Q I Y E +K L + V K++ D + +V+ YLLP ++ ++KT V
Sbjct: 605 KGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVV 664
Query: 1385 PKCTDPTYNEIVVYD-EVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKW 1437
K +P YNEI+ Y E L+ L L + + F N L V LD E W
Sbjct: 665 KKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETW 716
Score = 38.5 bits (88), Expect = 0.047
Identities = 21/55 (38%), Positives = 33/55 (60%)
Query: 1345 ILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYD 1399
I VK ++ L GS ++ V+ +LP S R+KT++V K T+P +N +VYD
Sbjct: 772 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYD 826
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,832,523
Number of Sequences: 37866
Number of extensions: 2552707
Number of successful extensions: 6672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 6491
Number of HSP's gapped (non-prelim): 196
length of query: 1445
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1330
effective length of database: 13,892,928
effective search space: 18477594240
effective search space used: 18477594240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.