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Search of human proteins with 194328806
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
(387 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 785 0.0
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 749 0.0
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 657 0.0
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 231 8e-61
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 201 9e-52
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 167 1e-41
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 162 5e-40
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 160 1e-39
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 160 1e-39
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 159 3e-39
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 159 5e-39
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 152 6e-37
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 141 9e-34
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 135 5e-32
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 130 3e-30
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 125 6e-29
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 125 6e-29
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 122 7e-28
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 122 7e-28
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 120 2e-27
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 118 8e-27
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 113 3e-25
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 113 3e-25
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 113 3e-25
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 113 3e-25
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 113 3e-25
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 113 3e-25
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 113 3e-25
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 113 3e-25
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 112 7e-25
>gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
Length = 387
Score = 785 bits (2026), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
Sbjct: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
Query: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
Sbjct: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
Query: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
Sbjct: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
Query: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLL 240
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLL
Sbjct: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLL 240
Query: 241 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 300
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
Sbjct: 241 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 300
Query: 301 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 360
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
Sbjct: 301 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 360
Query: 361 HSEQVFALRLQDKKLPPLLSEIWDVHE 387
HSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 361 HSEQVFALRLQDKKLPPLLSEIWDVHE 387
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 749 bits (1933), Expect = 0.0
Identities = 384/447 (85%), Positives = 386/447 (86%), Gaps = 60/447 (13%)
Query: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
Sbjct: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
Query: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
Sbjct: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
Query: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
Sbjct: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
Query: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT---- 236
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT
Sbjct: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM 240
Query: 237 ----------------------------------------------VMLLETS------- 243
+ LL+TS
Sbjct: 241 APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL 300
Query: 244 ---RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 300
RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
Sbjct: 301 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 360
Query: 301 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 360
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
Sbjct: 361 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 420
Query: 361 HSEQVFALRLQDKKLPPLLSEIWDVHE 387
HSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 421 HSEQVFALRLQDKKLPPLLSEIWDVHE 447
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 657 bits (1695), Expect = 0.0
Identities = 339/402 (84%), Positives = 341/402 (84%), Gaps = 60/402 (14%)
Query: 46 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 105
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA
Sbjct: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
Query: 106 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 165
SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE
Sbjct: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
Query: 166 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 225
ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN
Sbjct: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
Query: 226 RRSFSDRLRVT------------------------------------------------- 236
RRSFSDRLRVT
Sbjct: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
Query: 237 -VMLLETS----------RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 285
+ LL+TS RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA
Sbjct: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
Query: 286 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 345
MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP
Sbjct: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
Query: 346 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 387
RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 231 bits (589), Expect = 8e-61
Identities = 117/153 (76%), Positives = 133/153 (86%)
Query: 235 VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDA 294
+ +MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L L+DA
Sbjct: 309 IEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368
Query: 295 EFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSL 354
E+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLMKLVSL
Sbjct: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSL 428
Query: 355 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 387
RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 429 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
Score = 211 bits (537), Expect = 9e-55
Identities = 120/250 (48%), Positives = 153/250 (61%), Gaps = 29/250 (11%)
Query: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71
P S+++ PG A S + +EE P G V G + A
Sbjct: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62
Query: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130
P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G
Sbjct: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
Query: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189
Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ +
Sbjct: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
Query: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226
S P ++S P P QL+ Q MI++LVAAQ QCN+
Sbjct: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
Query: 227 RSFSDRLRVT 236
RSFSD+ +VT
Sbjct: 241 RSFSDQPKVT 250
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 201 bits (511), Expect = 9e-52
Identities = 130/383 (33%), Positives = 189/383 (49%), Gaps = 63/383 (16%)
Query: 63 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 122
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
Query: 123 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI---RLKKL 179
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q RL+K
Sbjct: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
Query: 180 KRQE-----EEQAHATSLPPRASSPPQILP--QLSPEQLGMIEKLVAAQQQCNRRSFSDR 232
+Q E + L S+ +L+P+Q ++ ++ + N++
Sbjct: 212 VKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSY---NKQRMPQE 268
Query: 233 LRVTVMLLETSRRYN----------------------PG------SESITFLKD------ 258
+ ++ E S N PG + I LK
Sbjct: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
Query: 259 FSYNREDFAK----------------AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAI 302
F + E F K +G+ E+I P+F F +++ EL++ E+ALL AI
Sbjct: 329 FLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAI 388
Query: 303 SIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHS 362
I S DR ++D+ VE+LQ ++ L IH P + F +L +L LRT + H+
Sbjct: 389 VILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHA 448
Query: 363 EQVFALRLQDKKLPPLLSEIWDV 385
E + + R+ D K PLL EIWDV
Sbjct: 449 EMLMSWRVNDHKFTPLLCEIWDV 471
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 167 bits (423), Expect = 1e-41
Identities = 114/410 (27%), Positives = 192/410 (46%), Gaps = 55/410 (13%)
Query: 18 VELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA---AEPTALLTRAEPPS 74
+E + PG + A G+ + R + GG+ GLE+ +P +L + +
Sbjct: 5 METFAPGPRRLYGAAGPGAGLLRR-------ATGGSCFAGLESFAWPQPASLQSVETQST 57
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y C
Sbjct: 58 SSEEMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 115
Query: 135 HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS--- 191
H +C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++ S
Sbjct: 116 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQL 175
Query: 192 ---LPPRASSPPQILPQLS---------------PEQLGMIEKLVAAQQQCNRR--SFSD 231
+ + + + P L LG+ +K +C + F+
Sbjct: 176 EELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAK 235
Query: 232 RLR------------------VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQV 273
RL + +++L RY P +++TF + NR AG
Sbjct: 236 RLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG- 294
Query: 274 EFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYV 333
+ +F F+ + L+++D E LL AI + DR ++++ +V++LQ +EAL Y
Sbjct: 295 PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYA 354
Query: 334 SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 382
P MFPRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 355 RRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 162 bits (410), Expect = 5e-40
Identities = 113/394 (28%), Positives = 188/394 (47%), Gaps = 48/394 (12%)
Query: 36 SSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGN 95
SSC+L+E+A +G T ++ T++ + E+ P P P++
Sbjct: 24 SSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQS---TSSEELVPSPPSPLPPPRVY-- 78
Query: 96 ELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRL 155
+ C VC DK+SG+HY V +CEGCKGFFRRS+ K Y CH +C ++ R +CQ CRL
Sbjct: 79 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRL 138
Query: 156 RKCRQAGMREECVLSEEQIRLKKLKRQE-----EEQAHATSLPPRASSPPQ-ILPQLSP- 208
+KC + GM +E V ++ + K+ +QE E A L + Q P L
Sbjct: 139 QKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQL 198
Query: 209 --------------EQLGMIEKLVAAQQQCNRR--SFSDRLR------------------ 234
LG+ +K +C + F+ RL
Sbjct: 199 GKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAAC 258
Query: 235 VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDA 294
+ +++L RY P +++TF + NR AG + +F F+ + L+++D
Sbjct: 259 LDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFTFANQLLPLEMDDT 317
Query: 295 EFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSL 354
E LL AI + DR ++++ +V++LQ +EAL Y+ P MFP++LMK+ L
Sbjct: 318 ETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDL 377
Query: 355 RTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 387
R++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 378 RSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 160 bits (406), Expect = 1e-39
Identities = 109/373 (29%), Positives = 177/373 (47%), Gaps = 48/373 (12%)
Query: 57 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 116
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 117 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 176
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 177 KKLKRQE-----------------EEQAHATSLP---------------PRASSPPQILP 204
K++ + E +AH + P R S +
Sbjct: 167 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD 226
Query: 205 QLSPEQLGMIEKLVAAQQQC---NRRSFSDRLR------VTVMLLETSRRYNPGSESITF 255
+ S I K V +Q + +D++ + +++L RY P +++TF
Sbjct: 227 KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF 286
Query: 256 LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQ 315
+ NR AG + +F F+ + L+++DAE LL AI + DR +++
Sbjct: 287 SDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQP 345
Query: 316 LQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKK 374
+V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 346 DRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGS 405
Query: 375 LPPLLSEIWDVHE 387
+PPL+ E+ + E
Sbjct: 406 MPPLIQEMLENSE 418
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 160 bits (406), Expect = 1e-39
Identities = 109/373 (29%), Positives = 177/373 (47%), Gaps = 48/373 (12%)
Query: 57 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 116
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 117 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 176
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 177 KKLKRQE-----------------EEQAHATSLP---------------PRASSPPQILP 204
K++ + E +AH + P R S +
Sbjct: 167 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD 226
Query: 205 QLSPEQLGMIEKLVAAQQQC---NRRSFSDRLR------VTVMLLETSRRYNPGSESITF 255
+ S I K V +Q + +D++ + +++L RY P +++TF
Sbjct: 227 KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF 286
Query: 256 LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQ 315
+ NR AG + +F F+ + L+++DAE LL AI + DR +++
Sbjct: 287 SDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQP 345
Query: 316 LQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKK 374
+V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 346 DRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGS 405
Query: 375 LPPLLSEIWDVHE 387
+PPL+ E+ + E
Sbjct: 406 MPPLIQEMLENSE 418
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 159 bits (403), Expect = 3e-39
Identities = 106/356 (29%), Positives = 171/356 (48%), Gaps = 45/356 (12%)
Query: 74 SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYI 133
S EI P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y
Sbjct: 61 SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT 118
Query: 134 CHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQE---------- 183
CH +C ++ R +CQ CRL+KC + GM +E V ++ + K++ + E
Sbjct: 119 CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPE 178
Query: 184 -------EEQAHATSLP---------------PRASSPPQILPQLSPEQLGMIEKLVAAQ 221
+AH + P R S + + S I K V
Sbjct: 179 VGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFA 238
Query: 222 QQC---NRRSFSDRLR------VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 272
+Q + +D++ + +++L RY P +++TF + NR AG
Sbjct: 239 KQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG 298
Query: 273 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY 332
+ +F F+ + L+++DAE LL AI + DR +++ +V+ LQ +EAL Y
Sbjct: 299 -PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
Query: 333 VSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 387
V P MFP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 413
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 159 bits (401), Expect = 5e-39
Identities = 101/347 (29%), Positives = 167/347 (48%), Gaps = 45/347 (12%)
Query: 78 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 137
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y CH
Sbjct: 72 EMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
Query: 138 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS------ 191
+C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++ S
Sbjct: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEEL 189
Query: 192 LPPRASSPPQILPQLS---------------PEQLGMIEKLVAAQQQCNRR--SFSDRLR 234
+ + + + P L LG+ +K +C + F+ RL
Sbjct: 190 ITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLP 249
Query: 235 ------------------VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFI 276
+ +++L RY P +++TF + NR AG
Sbjct: 250 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLT 308
Query: 277 NPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIH 336
+ +F F+ + L+++D E LL AI + DR ++++ +V++LQ +EAL Y
Sbjct: 309 DLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRR 368
Query: 337 HPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 382
P MFPRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 369 RPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 415
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 152 bits (383), Expect = 6e-37
Identities = 110/388 (28%), Positives = 184/388 (47%), Gaps = 88/388 (22%)
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
Query: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
Query: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--DRLRVTVMLLETSR---RY 246
R + P + L+ EQ MI +L+ AQ + +FS RV++ L Y
Sbjct: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNY 188
Query: 247 NPGSES-----------------------ITFLKDFSYNRE------------------- 264
P ++S I+F K SY R+
Sbjct: 189 KPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQ 248
Query: 265 -----------------------DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIA 301
+ G Q + P+ +F + +LQL++ E+ L+ A
Sbjct: 249 LRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQA 308
Query: 302 ISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRTLSS 359
IS+FS DRP V V++LQ + L +Y+ + P R +F +++ L LR++++
Sbjct: 309 ISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINA 368
Query: 360 VHSEQVFALRLQD--KKLPPLLSEIWDV 385
H++++ LR+QD PL+ E++ +
Sbjct: 369 QHTQRL--LRIQDIHPFATPLMQELFGI 394
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 141 bits (356), Expect = 9e-34
Identities = 105/344 (30%), Positives = 158/344 (45%), Gaps = 67/344 (19%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQI---RLKKLKR----------QEEEQAHATSLPPRASS------ 198
C AGMR++ +LS E + R K+ +R +E+E+ T L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
Query: 199 ------PP-------QILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRR 245
PP Q LP L+P + LV N ++ T L R
Sbjct: 131 QFVQFRPPAHLFIHHQPLPTLAP-----VLPLVTHFADINTFMVLQVIKFTKDL--PVFR 183
Query: 246 YNPGSESITFLKDFS-------------------------YNREDFAKAGLQVEFINPIF 280
P + I+ LK + Y ED A+ G QVEF+ +F
Sbjct: 184 SLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLF 243
Query: 281 EFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYV--SIHHP 338
F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y+ P
Sbjct: 244 HFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 303
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 382
DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 304 RDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 346
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 135 bits (341), Expect = 5e-32
Identities = 105/348 (30%), Positives = 158/348 (45%), Gaps = 71/348 (20%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQI---RLKKLKR----------QEEEQAHATSLPPRASS------ 198
C AGMR++ +LS E + R K+ +R +E+E+ T L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
Query: 199 ------PP-------QILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRR 245
PP Q LP L+P + LV N ++ T L R
Sbjct: 131 QFVQFRPPAHLFIHHQPLPTLAP-----VLPLVTHFADINTFMVLQVIKFTKDL--PVFR 183
Query: 246 YNPGSESITFLKDFS-------------------------YNREDFAKA----GLQVEFI 276
P + I+ LK + Y ED A+ G QVEF+
Sbjct: 184 SLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFL 243
Query: 277 NPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYV--S 334
+F F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y+
Sbjct: 244 ELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQ 303
Query: 335 IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 382
P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 304 QRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 350
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 130 bits (326), Expect = 3e-30
Identities = 105/353 (29%), Positives = 158/353 (44%), Gaps = 76/353 (21%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQI---RLKKLKR----------QEEEQAHATSLPPRASS------ 198
C AGMR++ +LS E + R K+ +R +E+E+ T L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
Query: 199 ------PP-------QILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRR 245
PP Q LP L+P + LV N ++ T L R
Sbjct: 131 QFVQFRPPAHLFIHHQPLPTLAP-----VLPLVTHFADINTFMVLQVIKFTKDL--PVFR 183
Query: 246 YNPGSESITFLKDFS-------------------------YNREDFAKA----GLQVEFI 276
P + I+ LK + Y ED A+ G QVEF+
Sbjct: 184 SLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFL 243
Query: 277 NPIFEFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQHTYVEALHA 331
+F F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +
Sbjct: 244 ELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQS 303
Query: 332 YV--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 382
Y+ P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 304 YIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 355
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 125 bits (314), Expect = 6e-29
Identities = 114/404 (28%), Positives = 174/404 (43%), Gaps = 51/404 (12%)
Query: 22 KPGAQDASSQAQGGSSCILREEARM-PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTE 78
+P A + S G S + + ++ P A G G + PTA L P E +
Sbjct: 185 QPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSG 244
Query: 79 I--RPQKRKKGPAPKMLGNE-LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICH 135
I P K + G+E C+VCGD AS HY V +CEGCKGFF+R+V K A YIC
Sbjct: 245 ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICL 304
Query: 136 SGGHCPMDTYMRRKCQECRLRKCRQAGMREECV----LSEEQIRLKKLKRQEEE------ 185
+ CP+D R +CQ CR +KC GM +E V L + RL +Q +
Sbjct: 305 ANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANL 364
Query: 186 -----QAHATSLPPRA-----SSPPQILPQLSPEQLGMIEKL------------------ 217
+AH S P A +LP E G +++
Sbjct: 365 LTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKI 424
Query: 218 --VAAQQQCNRRSFSDRLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEF 275
A ++ + + + +L + R PG + F +R A+ ++
Sbjct: 425 PGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARG--FGDW 482
Query: 276 INPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS- 334
I+ I FSR+++ L ++ FA L A+ + DR +Q+ +VE LQ+ L +V+
Sbjct: 483 IDSILAFSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEPRRVEELQNRIASCLKEHVAA 541
Query: 335 -IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPP 377
P R+L KL LRTL + +++F L+L+D PP
Sbjct: 542 VAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP 585
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 125 bits (314), Expect = 6e-29
Identities = 114/404 (28%), Positives = 174/404 (43%), Gaps = 51/404 (12%)
Query: 22 KPGAQDASSQAQGGSSCILREEARM-PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTE 78
+P A + S G S + + ++ P A G G + PTA L P E +
Sbjct: 185 QPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSG 244
Query: 79 I--RPQKRKKGPAPKMLGNE-LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICH 135
I P K + G+E C+VCGD AS HY V +CEGCKGFF+R+V K A YIC
Sbjct: 245 ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICL 304
Query: 136 SGGHCPMDTYMRRKCQECRLRKCRQAGMREECV----LSEEQIRLKKLKRQEEE------ 185
+ CP+D R +CQ CR +KC GM +E V L + RL +Q +
Sbjct: 305 ANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANL 364
Query: 186 -----QAHATSLPPRA-----SSPPQILPQLSPEQLGMIEKL------------------ 217
+AH S P A +LP E G +++
Sbjct: 365 LTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKI 424
Query: 218 --VAAQQQCNRRSFSDRLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEF 275
A ++ + + + +L + R PG + F +R A+ ++
Sbjct: 425 PGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARG--FGDW 482
Query: 276 INPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS- 334
I+ I FSR+++ L ++ FA L A+ + DR +Q+ +VE LQ+ L +V+
Sbjct: 483 IDSILAFSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEPRRVEELQNRIASCLKEHVAA 541
Query: 335 -IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPP 377
P R+L KL LRTL + +++F L+L+D PP
Sbjct: 542 VAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP 585
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 122 bits (305), Expect = 7e-28
Identities = 95/307 (30%), Positives = 136/307 (44%), Gaps = 70/307 (22%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQI---RLKKLKR----------QEEEQAHATSLPPRASS------ 198
C AGMR++ +LS E + R K+ +R +E+E+ T L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
Query: 199 ------PP-------QILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRR 245
PP Q LP L+P + LV N ++ T L R
Sbjct: 131 QFVQFRPPAHLFIHHQPLPTLAP-----VLPLVTHFADINTFMVLQVIKFTKDL--PVFR 183
Query: 246 YNPGSESITFLKDFS-------------------------YNREDFAKA----GLQVEFI 276
P + I+ LK + Y ED A+ G QVEF+
Sbjct: 184 SLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFL 243
Query: 277 NPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYV--S 334
+F F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y+
Sbjct: 244 ELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQ 303
Query: 335 IHHPHDR 341
P DR
Sbjct: 304 QRRPRDR 310
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 122 bits (305), Expect = 7e-28
Identities = 95/308 (30%), Positives = 136/308 (44%), Gaps = 71/308 (23%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQI---RLKKLKR----------QEEEQAHATSLPPRASS------ 198
C AGMR++ +LS E + R K+ +R +E+E+ T L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
Query: 199 ------PP-------QILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRR 245
PP Q LP L+P + LV N ++ T L R
Sbjct: 131 QFVQFRPPAHLFIHHQPLPTLAP-----VLPLVTHFADINTFMVLQVIKFTKDL--PVFR 183
Query: 246 YNPGSESITFLKDFS-------------------------YNREDFAKAGLQVEFINPIF 280
P + I+ LK + Y ED A+ G QVEF+ +F
Sbjct: 184 SLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLF 243
Query: 281 EFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQHTYVEALHAYV-- 333
F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y+
Sbjct: 244 HFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKG 303
Query: 334 SIHHPHDR 341
P DR
Sbjct: 304 QQRRPRDR 311
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 120 bits (302), Expect = 2e-27
Identities = 102/379 (26%), Positives = 157/379 (41%), Gaps = 46/379 (12%)
Query: 35 GSSCILREEARMPHSAGGTAGVGLE-AAEPTALLTRAEPPSEPTEIRPQKRKKG------ 87
GS + A P S A G+ A P++ L S +I+P G
Sbjct: 67 GSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNY 126
Query: 88 --PAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTY 145
+P L +C++CGD++SG HY V SCEGCKGFF+R++ K Y C C +D
Sbjct: 127 PSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKR 186
Query: 146 MRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS----LPPRASSPPQ 201
R +CQ CR +KC GM+ E V E Q + +R E E ATS +P +
Sbjct: 187 QRNRCQYCRYQKCLVMGMKREAVQEERQ---RSRERAESEAECATSGHEDMPVERILEAE 243
Query: 202 ILPQLSPEQLGMI------------------EKLVAAQQQCNR-RSFSD-RLRVTVMLLE 241
+ + E G + ++L + R FSD L V+LL
Sbjct: 244 LAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLR 303
Query: 242 T----------SRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQL 291
S R + I +R AG+ F + E M ++Q+
Sbjct: 304 AGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQM 363
Query: 292 NDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKL 351
+ +E L AI +F+ D + + +VE L+ L AY +P F ++L++L
Sbjct: 364 DKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRL 423
Query: 352 VSLRTLSSVHSEQVFALRL 370
+LR++ E +F +L
Sbjct: 424 PALRSIGLKCLEHLFFFKL 442
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 118 bits (296), Expect = 8e-27
Identities = 93/373 (24%), Positives = 151/373 (40%), Gaps = 54/373 (14%)
Query: 47 PHSAG--GTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKG-------PAPKMLG--N 95
PHS T +G P L + P S +I+P G P+ M
Sbjct: 74 PHSMSVPTTPTLGFSTGSPQ-LSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTK 132
Query: 96 ELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRL 155
+C++CGD++SG HY V SCEGCKGFF+R+V K Y C C +D R +CQ CR
Sbjct: 133 HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRY 192
Query: 156 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSL----------------------- 192
+KC GM+ E V E Q + K + E + +TS
Sbjct: 193 QKCLAMGMKREAVQEERQ----RGKDRNENEVESTSSANEDMPVERILEAELAVEPKTET 248
Query: 193 ---------PPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRV------TV 237
P + P + Q + +QL + + + D++ + +
Sbjct: 249 YVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNEL 308
Query: 238 MLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFA 297
++ S R + I +R AG+ F + E M ++Q++ E
Sbjct: 309 LIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELG 368
Query: 298 LLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTL 357
L AI +F+ D + + +VE L+ +L AY +P F ++L++L +LR++
Sbjct: 369 CLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSI 428
Query: 358 SSVHSEQVFALRL 370
E +F +L
Sbjct: 429 GLKCLEHLFFFKL 441
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 42 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 93
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 94 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 148
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 149 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 208
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 209 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 268
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 269 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 328
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 329 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 373
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 42 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 93
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 94 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 148
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 149 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 208
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 209 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 268
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 269 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 328
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 329 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 373
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 42 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 93
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 94 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 148
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 149 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 208
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 209 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 268
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 269 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 328
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 329 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 373
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 20 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 72 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 126
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 127 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 186
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 187 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 246
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 247 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 306
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 307 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 20 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 72 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 126
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 127 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 186
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 187 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 246
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 247 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 306
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 307 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 113 bits (283), Expect = 3e-25
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 48/345 (13%)
Query: 73 PSEPTEIRPQKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH 131
PSE T + AP LG + LC++CGD+A+G HY SC+GCKGFFRRSV K
Sbjct: 20 PSEGTNLN--------APNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y C C +D R +C+ CRL+KC +AGM++E V +E R+ + E+ +S
Sbjct: 72 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERD-RISTRRSSYED----SS 126
Query: 192 LPP-RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPG- 249
LP A ++L + + I + A++ + + ++ +++L +Y P
Sbjct: 127 LPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAF 186
Query: 250 -----SESITFLK--------------------------DFSYNREDFAKAGLQVEFINP 278
+ + L+ D+ R A + I
Sbjct: 187 CELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI 246
Query: 279 IFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP 338
+ E ELQ++D E+A L AI F D + D +++RL+ +L Y++
Sbjct: 247 LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 306
Query: 339 HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD-KKLPPLLSEI 382
R F +L+ L +L++++ EQ+ ++L K+ LL E+
Sbjct: 307 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
2 [Homo sapiens]
Length = 473
Score = 113 bits (282), Expect = 3e-25
Identities = 61/159 (38%), Positives = 95/159 (59%), Gaps = 12/159 (7%)
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 57 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 116
Query: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 117 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 170
Query: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS 230
R + P + L+ EQ MI +L+ AQ + +FS
Sbjct: 171 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFS 206
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/130 (32%), Positives = 75/130 (57%), Gaps = 7/130 (5%)
Query: 260 SYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVE 319
SY ED A G Q + P+ +F + +LQL++ E+ L+ AIS+FS DRP V V+
Sbjct: 344 SYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVD 402
Query: 320 RLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKL 375
+LQ + L +Y+ + P R +F +++ L LR++++ H++++ LR+QD
Sbjct: 403 QLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFA 460
Query: 376 PPLLSEIWDV 385
PL+ E++ +
Sbjct: 461 TPLMQELFGI 470
>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
1 [Homo sapiens]
Length = 434
Score = 113 bits (282), Expect = 3e-25
Identities = 61/159 (38%), Positives = 95/159 (59%), Gaps = 12/159 (7%)
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
Query: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
Query: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS 230
R + P + L+ EQ MI +L+ AQ + +FS
Sbjct: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFS 167
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/130 (32%), Positives = 75/130 (57%), Gaps = 7/130 (5%)
Query: 260 SYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVE 319
SY ED A G Q + P+ +F + +LQL++ E+ L+ AIS+FS DRP V V+
Sbjct: 305 SYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVD 363
Query: 320 RLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKL 375
+LQ + L +Y+ + P R +F +++ L LR++++ H++++ LR+QD
Sbjct: 364 QLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFA 421
Query: 376 PPLLSEIWDV 385
PL+ E++ +
Sbjct: 422 TPLMQELFGI 431
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 112 bits (279), Expect = 7e-25
Identities = 94/342 (27%), Positives = 159/342 (46%), Gaps = 53/342 (15%)
Query: 88 PAPKMLGNE----LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMD 143
P+P G+ LC+VCGD A+ HY V +CEGCKGFF+R+V K A Y+C + +CP+D
Sbjct: 249 PSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVD 308
Query: 144 TYMRRKCQECRLRKCRQAGMREECV----LSEEQIRLKKLKRQEEE-------------- 185
R +CQ CR +KC GM +E V L + RL + +E
Sbjct: 309 KRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISAL 368
Query: 186 -QAHATSLPPRAS---SPPQILP--QLSPEQL------------------GMIEKL--VA 219
+AH S P S S Q P Q+S + G EK+ A
Sbjct: 369 VRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFA 428
Query: 220 AQQQCNRRSFSDRLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPI 279
+ ++ + + + +L + R NP + F +R + E+I+ I
Sbjct: 429 DLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRG--FGEWIDSI 486
Query: 280 FEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHP- 338
EFS + + ++ + F+ + A+++ + +R +++ +VE LQ+ V L +V+ ++
Sbjct: 487 VEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQNKIVNCLKDHVTFNNGG 545
Query: 339 -HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL 379
+ ++L KL LRTL + +++F L+L+D PP +
Sbjct: 546 LNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,376,820
Number of Sequences: 37866
Number of extensions: 780826
Number of successful extensions: 4390
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 4081
Number of HSP's gapped (non-prelim): 329
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.