Guide to the Human Genome
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Search of human proteins with 194306623

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
         (745 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194306623 immunoglobulin superfamily containing leucine-rich ...  1512   0.0  
gi|194306621 immunoglobulin superfamily containing leucine-rich ...  1512   0.0  
gi|39930401 immunoglobulin superfamily containing leucine-rich r...  1512   0.0  
gi|194306618 immunoglobulin superfamily containing leucine-rich ...  1512   0.0  
gi|41582239 immunoglobulin superfamily containing leucine-rich r...   383   e-106
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   383   e-106
gi|13375646 leucine rich repeat and fibronectin type III domain ...   123   7e-28
gi|27363458 leucine rich repeat and fibronectin type III domain ...   122   2e-27
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         118   2e-26
gi|188528675 slit homolog 1 [Homo sapiens]                            116   7e-26
gi|4759146 slit homolog 2 [Homo sapiens]                              115   2e-25
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          115   2e-25
gi|11321571 slit homolog 3 [Homo sapiens]                             114   4e-25
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm...   114   4e-25
gi|109150416 peroxidasin [Homo sapiens]                               110   6e-24
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             107   3e-23
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             107   3e-23
gi|139948432 adlican [Homo sapiens]                                   107   5e-23
gi|14149694 retina specific protein PAL [Homo sapiens]                105   2e-22
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...   104   3e-22
gi|31542244 leucine rich repeat and fibronectin type III domain ...    99   1e-20
gi|51317373 netrin-G1 ligand [Homo sapiens]                            98   3e-20
gi|194440719 chondroadherin-like [Homo sapiens]                        95   2e-19
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    95   3e-19
gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]           93   8e-19
gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]           93   8e-19
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    93   8e-19
gi|59823631 G protein-coupled receptor 125 [Homo sapiens]              93   8e-19
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    93   1e-18
gi|62988340 leucine rich repeat containing 22 [Homo sapiens]           92   2e-18

>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60
           MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA
Sbjct: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60

Query: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120
           NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR
Sbjct: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120

Query: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180
           NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH
Sbjct: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180

Query: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240
           NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE
Sbjct: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240

Query: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300
           PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG
Sbjct: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300

Query: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360
           EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE
Sbjct: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360

Query: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420
           LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ
Sbjct: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420

Query: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480
           GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK
Sbjct: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480

Query: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540
           PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA
Sbjct: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540

Query: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600
           VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL
Sbjct: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600

Query: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660
           LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA
Sbjct: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660

Query: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720
           GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS
Sbjct: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720

Query: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745
           DRLPLGAEAVNIAQEINGNYRQTAG
Sbjct: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60
           MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA
Sbjct: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60

Query: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120
           NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR
Sbjct: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120

Query: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180
           NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH
Sbjct: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180

Query: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240
           NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE
Sbjct: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240

Query: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300
           PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG
Sbjct: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300

Query: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360
           EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE
Sbjct: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360

Query: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420
           LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ
Sbjct: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420

Query: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480
           GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK
Sbjct: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480

Query: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540
           PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA
Sbjct: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540

Query: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600
           VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL
Sbjct: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600

Query: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660
           LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA
Sbjct: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660

Query: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720
           GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS
Sbjct: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720

Query: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745
           DRLPLGAEAVNIAQEINGNYRQTAG
Sbjct: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60
           MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA
Sbjct: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60

Query: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120
           NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR
Sbjct: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120

Query: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180
           NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH
Sbjct: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180

Query: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240
           NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE
Sbjct: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240

Query: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300
           PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG
Sbjct: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300

Query: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360
           EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE
Sbjct: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360

Query: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420
           LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ
Sbjct: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420

Query: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480
           GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK
Sbjct: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480

Query: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540
           PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA
Sbjct: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540

Query: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600
           VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL
Sbjct: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600

Query: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660
           LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA
Sbjct: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660

Query: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720
           GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS
Sbjct: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720

Query: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745
           DRLPLGAEAVNIAQEINGNYRQTAG
Sbjct: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60
           MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA
Sbjct: 1   MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60

Query: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120
           NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR
Sbjct: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120

Query: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180
           NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH
Sbjct: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180

Query: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240
           NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE
Sbjct: 181 NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE 240

Query: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300
           PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG
Sbjct: 241 PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG 300

Query: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360
           EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE
Sbjct: 301 EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE 360

Query: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420
           LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ
Sbjct: 361 LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ 420

Query: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480
           GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK
Sbjct: 421 GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK 480

Query: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540
           PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA
Sbjct: 481 PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA 540

Query: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600
           VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL
Sbjct: 541 VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL 600

Query: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660
           LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA
Sbjct: 601 LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA 660

Query: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720
           GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS
Sbjct: 661 GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS 720

Query: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745
           DRLPLGAEAVNIAQEINGNYRQTAG
Sbjct: 721 DRLPLGAEAVNIAQEINGNYRQTAG 745


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58

Query: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118

Query: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178

Query: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238

Query: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287

Query: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331

Query: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379

Query: 412 KPEGKI 417
            PE  +
Sbjct: 380 GPEDNV 385


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58

Query: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118

Query: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178

Query: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238

Query: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287

Query: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331

Query: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379

Query: 412 KPEGKI 417
            PE  +
Sbjct: 380 GPEDNV 385


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score =  123 bits (308), Expect = 7e-28
 Identities = 111/384 (28%), Positives = 158/384 (41%), Gaps = 82/384 (21%)

Query: 42  LREVPEGLPANVTTLS---LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
           +R V  G  A++  L    L  N++T L  G    +  +  L L++N++  +  GAL   
Sbjct: 95  IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDC 154

Query: 99  SQ-LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
           ++ L++LDLS+N +   PW  L  L  +  L ++HN L S+P  A   L  L  L + +N
Sbjct: 155 AETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSN 214

Query: 158 RLRTLAPG-TFDALSALSH----------LQLYHNPFHCGCGLVWLQAWAASTRVSLPEP 206
           RL T+ P   F  L  L+           L    NP HC C LVWL+  A        E 
Sbjct: 215 RLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR-------ED 267

Query: 207 DSIACASPPALQGVPVYRL--PALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
           D  ACASPPAL G   + +      C PP V     PPL  P     AG    L C A G
Sbjct: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVP-----AGRPAALRCRAVG 321

Query: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWP 324
            P PR++W          + P                    G LL  +            
Sbjct: 322 DPEPRVRW----------VSP-------------------QGRLLGNSS----------- 341

Query: 325 APPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHA--- 381
                 R  A  NG+L + +    + G++TC A N  G  + ++ + V    PP+ A   
Sbjct: 342 ------RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANST 395

Query: 382 ---PGAGGEPDGQAPTSERKSTAK 402
              P   G+PD   P S   ++AK
Sbjct: 396 SCDPPRDGDPDALTPPSAASASAK 419


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  122 bits (305), Expect = 2e-27
 Identities = 122/464 (26%), Positives = 175/464 (37%), Gaps = 121/464 (26%)

Query: 9   LVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLP------------------ 50
           L+  L   A +CP PC C +        CA++ L  VP  +                   
Sbjct: 6   LLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGP 65

Query: 51  ------ANVTTLSLSANKITVLRRGAFADVTQVTSLWL---------------------- 82
                   +  L+LS N IT +   AF D+  + SL L                      
Sbjct: 66  PDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHL 125

Query: 83  --AHNEVRTVEPGALA-VLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
             + N++  + PGA    L  L++LDLS+N +   PW+ +  + AL  L ++HN + +LP
Sbjct: 126 ILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALP 185

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTF-------DALSALSHLQLYHNPFHCGCGLVWL 192
             A   L  L  L + +NRL TLAP          +A  A   L    NP HC C L+WL
Sbjct: 186 PGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELLWL 245

Query: 193 QAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTP--- 249
           +      R++ P+ D   CASPP L G   +       A P    S EPPL A  T    
Sbjct: 246 R------RLARPD-DLETCASPPGLAGRYFW-------AVPEGEFSCEPPLIARHTQRLW 291

Query: 250 LRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLL 309
           +  G    L C A G P P + W                 G DD +              
Sbjct: 292 VLEGQRATLRCRALGDPAPTMHW----------------VGPDDRLVGN----------- 324

Query: 310 TQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIR 369
                              + R  A  NG+L + +  A +AG YTC A N  G  +  + 
Sbjct: 325 -------------------SSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVE 365

Query: 370 VAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKP 413
           + V A     ++   GG P      +  ++ A+G G   L S+P
Sbjct: 366 LRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEG--TLESEP 407


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  118 bits (296), Expect = 2e-26
 Identities = 116/418 (27%), Positives = 156/418 (37%), Gaps = 75/418 (17%)

Query: 17  AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
           A  CP  C C         +C    LR VP G+P    TL L  N I  L  GA A +  
Sbjct: 20  AAGCPAACRCYSATV----ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75

Query: 77  VTSLWLAHNEVRTVEPGALAV------------------------LSQLKNLDLSHNFIS 112
           +  L+L +N +R +E GA                           L+QL+ L L+ N ++
Sbjct: 76  LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135

Query: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
                   +L  LQ L +  N +  L   AL  L  L  L ++ N+L T++      L++
Sbjct: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195

Query: 173 LSHLQLYHNPFHCGCGLVWLQAW--AASTRVSLPEPDSIACASPP--ALQGVPVYRLPAL 228
           L  L+L  NP+ C C L WL AW      R+       I CA PP  ALQ +      +L
Sbjct: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255

Query: 229 PCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW-QLQIPGGTVVLEPPV 287
            C PPSVH+    PLE        G    + C A G+P P + W ++  P          
Sbjct: 256 ICIPPSVHVQ---PLELTA---NLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309

Query: 288 LSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSA 347
           L G   G+G       G G                          L L+N       ++ 
Sbjct: 310 LEGGLLGLGGHSASDTGSG-------------------------MLFLSN-------ITL 337

Query: 348 KEAGVYTCRAHNELGANSTSIRVAVAAT----GPPKHAPGAGGEPDGQAPTSERKSTA 401
             AG Y C A N  GA     R+ V A+      P   P     P G  P  E  S A
Sbjct: 338 AHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMA 395


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  116 bits (291), Expect = 7e-26
 Identities = 62/204 (30%), Positives = 106/204 (51%), Gaps = 8/204 (3%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRR-GAFADVTQVT 78
           CP  C C         +C+  +L ++PE +P +   L L+ N+I++L   G F  +T + 
Sbjct: 513 CPHKCRC----EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568

Query: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSL 138
            + L++N+V  +E GA    + +  L L+ N + S      R L  L+ L + +NR+  +
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628

Query: 139 PRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAS 198
             D+   L ++R L + +N++ T++PG FD L +LS L L  NPF+C C L WL  W   
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688

Query: 199 TRVSLPEPDSIACASPPALQGVPV 222
            ++    P    C +P  L+ +P+
Sbjct: 689 RKIVTGNP---RCQNPDFLRQIPL 709



 Score =  114 bits (286), Expect = 3e-25
 Identities = 73/224 (32%), Positives = 108/224 (48%), Gaps = 35/224 (15%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           CP+ CAC+D        C+ K LR +P+G+P NVT L L  N+ T++             
Sbjct: 734 CPQECACLDTVVR----CSNKHLRALPKGIPKNVTELYLDGNQFTLV------------- 776

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
                       PG L+    L+ +DLS+N ISS   S   N+S L  L +++N L  +P
Sbjct: 777 ------------PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAST 199
             A   L  LR L ++ N + TL  G F  +++LSHL +  NP +C C L WL +W    
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW---V 881

Query: 200 RVSLPEPDSIACASPPALQGVPVYRLPA--LPC-APPSVHLSAE 240
           +    EP    CA P  ++G  +   PA    C  PP++ + A+
Sbjct: 882 KTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAK 925



 Score =  112 bits (281), Expect = 1e-24
 Identities = 69/201 (34%), Positives = 101/201 (50%), Gaps = 7/201 (3%)

Query: 17  AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
           +GSCP  C C    ++   DC  K L  +P  LP  +T + L  N I  +  GAF+   +
Sbjct: 279 SGSCPAMCTC----SNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334

Query: 77  VTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLG 136
           +  + L++N++  + P A   L  L +L L  N I+  P      L  LQLL +N N++ 
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394

Query: 137 SLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWA 196
            +  DA   L +L  L + +N++++LA GTF +L A+  L L  NPF C C L WL   A
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWL---A 451

Query: 197 ASTRVSLPEPDSIACASPPAL 217
              R +  E     CASP  L
Sbjct: 452 DFLRTNPIETSGARCASPRRL 472



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 71/248 (28%), Positives = 114/248 (45%), Gaps = 44/248 (17%)

Query: 7   LWLV-WAL---LGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62
           LWL+ WA    LG A +CP  C C         DC    L+ +P+ +P N   L L+ N 
Sbjct: 18  LWLLLWAAAWRLG-ASACPALCTCTGTTV----DCHGTGLQAIPKNIPRNTERLELNGNN 72

Query: 63  ITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNL 122
           IT + +  FA + Q+  L L  N++  VE GA   + +L+ L L+ N +   P    +N 
Sbjct: 73  ITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNN 132

Query: 123 SALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDAL------------ 170
            AL  L ++ N + ++PR A     DL++L+++ N++  +  G F AL            
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN 192

Query: 171 ------SALSHL------QLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIA----CASP 214
                 S+ +H+      +L+ N   C C L WL  W       L +  +I     C+ P
Sbjct: 193 ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW-------LRQRPTIGLFTQCSGP 245

Query: 215 PALQGVPV 222
            +L+G+ V
Sbjct: 246 ASLRGLNV 253


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  115 bits (287), Expect = 2e-25
 Identities = 68/198 (34%), Positives = 100/198 (50%), Gaps = 7/198 (3%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           CP  C C    ++   DC  K L E+P  LP  +T + L  N I V+  GAF+   ++  
Sbjct: 273 CPAACTC----SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
           + L++N++  + P A   L  L +L L  N I+  P S    L +LQLL +N N++  L 
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAST 199
            DA   L +L  L + +N+L+T+A GTF  L A+  + L  NPF C C L WL  +  + 
Sbjct: 389 VDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTN 448

Query: 200 RVSLPEPDSIACASPPAL 217
            +   E     C SP  L
Sbjct: 449 PI---ETSGARCTSPRRL 463



 Score =  113 bits (283), Expect = 6e-25
 Identities = 63/205 (30%), Positives = 104/205 (50%), Gaps = 8/205 (3%)

Query: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRR-GAFADVTQV 77
           +CPE C C         DC+ ++L ++PE +P     L L+ N+ TVL   G F  + Q+
Sbjct: 505 ACPEKCRCEGTTV----DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560

Query: 78  TSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGS 137
             +  ++N++  +E GA    S +  + L+ N + +      + L +L+ L +  NR+  
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620

Query: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197
           +  D+   L  +R L + +N++ T+APG FD L +LS L L  NPF+C C L WL  W  
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR 680

Query: 198 STRVSLPEPDSIACASPPALQGVPV 222
             R+    P    C  P  L+ +P+
Sbjct: 681 KKRIVTGNP---RCQKPYFLKEIPI 702



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 70/241 (29%), Positives = 106/241 (43%), Gaps = 35/241 (14%)

Query: 6   ALWLVWALLGVAG--SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKI 63
           +L LV A+L      +CP  C+C    +    DC    LR VP  +P N   L L+ N I
Sbjct: 12  SLGLVLAILNKVAPQACPAQCSC----SGSTVDCHGLALRSVPRNIPRNTERLDLNGNNI 67

Query: 64  TVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLK--------------------- 102
           T + +  FA +  +  L L  N++ T+E GA   L +L+                     
Sbjct: 68  TRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTA 127

Query: 103 ---NLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRL 159
               LDLS N I + P    R    ++ L++++N++  +   A  AL DL  L +NNN +
Sbjct: 128 KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNI 187

Query: 160 RTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAS-TRVSLPEPDSIACASPPALQ 218
             L+  +F+ +  L   +L+ N  +C C L WL  W     RV L       C  P  L+
Sbjct: 188 TRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGL----YTQCMGPSHLR 243

Query: 219 G 219
           G
Sbjct: 244 G 244



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 60/195 (30%), Positives = 88/195 (45%), Gaps = 32/195 (16%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           CP  C C+D        C+ K L+ +P+G+P +VT L L  N+ T++             
Sbjct: 727 CPTECTCLDTVVR----CSNKGLKVLPKGIPRDVTELYLDGNQFTLV------------- 769

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
                       P  L+    L  +DLS+N IS+       N++ L  L +++NRL  +P
Sbjct: 770 ------------PKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAST 199
                 L  LR L ++ N +  +  G F+ LSALSHL +  NP +C C + WL  W  S 
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKS- 876

Query: 200 RVSLPEPDSIACASP 214
                EP    CA P
Sbjct: 877 --EYKEPGIARCAGP 889


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  115 bits (287), Expect = 2e-25
 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%)

Query: 8   WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58
           W VWA +    S         CPE C CV       A C+   L  VP GL   +  L L
Sbjct: 22  WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78

Query: 59  SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118
             N++  L  GAFA    +  L L  N + +V   A   L  L+ LDLS N + +     
Sbjct: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138

Query: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178
              L AL+ L +  NRL  L   ALGALP LRSL + +N L  LAPG    L AL  L L
Sbjct: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198

Query: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222
             NP+ CGC L  L AW     +   E +++ C  P  L   P+
Sbjct: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  114 bits (284), Expect = 4e-25
 Identities = 64/204 (31%), Positives = 102/204 (50%), Gaps = 8/204 (3%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRR-GAFADVTQVT 78
           CPE C C         DC+ ++L  +P  LP  VT L L+ N+++VL   G F  +  + 
Sbjct: 505 CPEKCRCEGT----IVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560

Query: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSL 138
            + L++N+++ V  GA    + ++ L L+ N + +      R LS L+ L +  N +G +
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620

Query: 139 PRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAS 198
             D    L  +R L + +NR+ T+ PG F  L +LS + L  NPF+C C L WL  W   
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680

Query: 199 TRVSLPEPDSIACASPPALQGVPV 222
            R+    P    C  P  L+ +P+
Sbjct: 681 RRIVSGNP---RCQKPFFLKEIPI 701



 Score =  105 bits (262), Expect = 2e-22
 Identities = 64/195 (32%), Positives = 91/195 (46%), Gaps = 32/195 (16%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           CPE C C++        C+ K LR +P G+P +VT L L  N +T +             
Sbjct: 725 CPEQCTCMETVVR----CSNKGLRALPRGMPKDVTELYLEGNHLTAV------------- 767

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
                       P  L+ L  L  +DLS+N IS        N+S L  L +++NRL  +P
Sbjct: 768 ------------PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIP 815

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAST 199
             A   L  LR L ++ N + ++  G+F+ L++LSHL L  NP HC C L WL  W    
Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEW---V 872

Query: 200 RVSLPEPDSIACASP 214
           +    EP    C+SP
Sbjct: 873 KAGYKEPGIARCSSP 887



 Score =  104 bits (259), Expect = 3e-22
 Identities = 61/199 (30%), Positives = 94/199 (47%), Gaps = 7/199 (3%)

Query: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVT 78
           SCP PC C    ++   DC  K L E+P  LP  +  + L  N I  +  GAF    ++ 
Sbjct: 279 SCPSPCTC----SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334

Query: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSL 138
            + ++ N++  + P A   L  L +L L  N I+         L +LQLL +N N++  L
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394

Query: 139 PRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAAS 198
             +    L +L  L + +N+L+T++ G F  L ++  L L  NPF C C L WL  +   
Sbjct: 395 RVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQD 454

Query: 199 TRVSLPEPDSIACASPPAL 217
             +   E     C+SP  L
Sbjct: 455 NPI---ETSGARCSSPRRL 470



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 72/254 (28%), Positives = 107/254 (42%), Gaps = 38/254 (14%)

Query: 17  AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
           A +CP  C C    +    DC    LR VP G+P N   L L  N IT + +  FA +  
Sbjct: 31  AVACPTKCTC----SAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKN 86

Query: 77  VTSLWLAHNEVRTVEPGALAVLSQLKNL------------------------DLSHNFIS 112
           +  L L  N+V  +E GA   L QL+ L                        DLS N I 
Sbjct: 87  LRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQ 146

Query: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
             P    R ++ ++ L++++N +  +   A  AL DL  L +NNN +  +   +F+ +  
Sbjct: 147 GIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPK 206

Query: 173 LSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV-------YRL 225
           +  L+L+ N  +C C L WL  W    R          C +P  L+G  V       Y  
Sbjct: 207 IRTLRLHSNHLYCDCHLAWLSDWLRQRRT---VGQFTLCMAPVHLRGFNVADVQKKEYVC 263

Query: 226 PALPCAPPSVHLSA 239
           PA    PPS + ++
Sbjct: 264 PAPHSEPPSCNANS 277


>gi|193083136 leucine-rich repeat, immunoglobulin-like and
           transmembrane domains 3 [Homo sapiens]
          Length = 634

 Score =  114 bits (284), Expect = 4e-25
 Identities = 95/390 (24%), Positives = 157/390 (40%), Gaps = 71/390 (18%)

Query: 41  ELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100
           ++ E+P  LP +   L +    I  +   AF  + ++  LW+ +N V +++P +   L Q
Sbjct: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61

Query: 101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR 160
           L  L L  N +++FPW+ L ++  L+ L +++N++ S+P +AL  L +L  L +++NRL 
Sbjct: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121

Query: 161 TLAP--------------GTFDALSALSHLQLYHNPFHCGCGLVWL--QAWAASTRVSLP 204
           TL P              G  D   +   L L  NP+ C C +  +   +      + L 
Sbjct: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181

Query: 205 EPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
           +P  + C+ P  L G+   R     C  PSV  SA   + A G+ +      +L C A G
Sbjct: 182 DP-LMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNV------LLRCDATG 234

Query: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW 323
            PTP++ W                                D   +  T  Q +P     W
Sbjct: 235 FPTPQITWT-----------------------------RSDSSPVNYTVIQESPEEGVRW 265

Query: 324 PAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG----PPK 379
                T               +S+K+AG Y C+A N  G +   + V V        PP 
Sbjct: 266 SIMSLTG--------------ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPD 311

Query: 380 HAPGAGGEPDGQAPTSERKSTAKGRGNSVL 409
            +   G  P+        +ST+    +S L
Sbjct: 312 TSERTGDHPEWDVQPGSGRSTSVSSASSYL 341


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  110 bits (274), Expect = 6e-24
 Identities = 78/273 (28%), Positives = 123/273 (45%), Gaps = 18/273 (6%)

Query: 7   LWLVWALLGVAGS-----CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSAN 61
           L+  W  L V        CP  C C          C +  L  VP   P   + L L  N
Sbjct: 18  LFCAWGTLAVVAQKPGAGCPSRCLCFRTTVR----CMHLLLEAVPAVAP-QTSILDLRFN 72

Query: 62  KITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRN 121
           +I  ++ GAF  +  + +L L +N+++ +  GA   L  LK L L  N I S      + 
Sbjct: 73  RIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKG 132

Query: 122 LSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
           L++L+ L ++ N++ +L  D+   LP L  L ++NNR+  L PGTF+ L ++  L+L  N
Sbjct: 133 LASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSN 192

Query: 182 PFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL--PALPCAPPSVHLSA 239
             HC C ++WL     +   S     +  C  P  +QG  V  +    L C  P   +++
Sbjct: 193 TLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERP--RITS 250

Query: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW 272
           EP        + +G      C A+G+P P + W
Sbjct: 251 EP----QDADVTSGNTVYFTCRAEGNPKPEIIW 279



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 11/30 (36%), Positives = 16/30 (53%)

Query: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQW 272
           ++   T +  G +  L C A GHP PR+ W
Sbjct: 346 IQPQNTEVLVGESVTLECSATGHPPPRISW 375


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  107 bits (268), Expect = 3e-23
 Identities = 99/339 (29%), Positives = 144/339 (42%), Gaps = 57/339 (16%)

Query: 42  LREVP----EGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAV 97
           LRE+     EGL + + +LS   N++  + R A   V  +  L L  N ++ V PG  A 
Sbjct: 225 LREISDYALEGLQS-LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFAN 283

Query: 98  LSQLKNLDLSHN----FISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLR 153
           +  LK L L++      I  F   +L  L+ L +   N+ RL  +   A   LP + +L 
Sbjct: 284 MLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQMETLM 341

Query: 154 INNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACAS 213
           +NNN L  L   T ++L  L  + L+ NP  C C + W  A A  TRV   EP S  CA 
Sbjct: 342 LNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRW--ANATGTRVRFIEPQSTLCAE 399

Query: 214 PPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQ 273
           PP LQ +PV  +P        + L   P    P   + +G + VLHC A   P P + W 
Sbjct: 400 PPDLQRLPVREVPFREMTDHCLPL-ISPRSFPPSLQVASGESMVLHCRALAEPEPEIYW- 457

Query: 274 LQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFL 333
                                                     TP      PA  A  R+ 
Sbjct: 458 -----------------------------------------VTPAGLRLTPA-HAGRRYR 475

Query: 334 ALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
               G+L +  ++A+EAG+YTC A N +GA++ ++ V V
Sbjct: 476 VYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 14/193 (7%)

Query: 3   PLRALWLVWALLGVAG-----SCPEPCAC------VDKYAHQFA---DCAYKELREVPEG 48
           PL   W+  A   V        CP  CAC        + +++ A   DC    L  VP  
Sbjct: 7   PLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPA 66

Query: 49  LPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSH 108
           LPA   TL L +N I  + +     +  +T L L+ N            L QL +L L  
Sbjct: 67  LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126

Query: 109 NFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFD 168
           N ++         L++LQ L +NHN+L  +   A   L +L  L +N+N LR +    F+
Sbjct: 127 NQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFE 186

Query: 169 ALSALSHLQLYHN 181
            L  L  L +  N
Sbjct: 187 MLPNLEILMIGGN 199



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 5/155 (3%)

Query: 27  VDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNE 86
           +D   + F+D    +   +P+ L     +L L  N++T L   +FA +  +  L+L HN+
Sbjct: 98  LDLSQNSFSDARDCDFHALPQLL-----SLHLEENQLTRLEDHSFAGLASLQELYLNHNQ 152

Query: 87  VRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGAL 146
           +  + P A + LS L  L L+ N + +        L  L++L +  N++ ++       L
Sbjct: 153 LYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPL 212

Query: 147 PDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
            +LRSL +    LR ++    + L +L  L  Y N
Sbjct: 213 ANLRSLVLAGMNLREISDYALEGLQSLESLSFYDN 247



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 12/86 (13%)

Query: 537 GGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQV--VFSTKKEL------- 587
           G  A   +R+  G ++Y    L   T Y  CL +A    H Q+  V++  KE        
Sbjct: 566 GQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEATSCHRAL 625

Query: 588 ---PSLLVIVAVSVFLLVLATVPLLG 610
              P L+ I+A++V LL       LG
Sbjct: 626 GDRPGLIAILALAVLLLAAGLAAHLG 651


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  107 bits (268), Expect = 3e-23
 Identities = 99/339 (29%), Positives = 144/339 (42%), Gaps = 57/339 (16%)

Query: 42  LREVP----EGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAV 97
           LRE+     EGL + + +LS   N++  + R A   V  +  L L  N ++ V PG  A 
Sbjct: 225 LREISDYALEGLQS-LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFAN 283

Query: 98  LSQLKNLDLSHN----FISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLR 153
           +  LK L L++      I  F   +L  L+ L +   N+ RL  +   A   LP + +L 
Sbjct: 284 MLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQMETLM 341

Query: 154 INNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACAS 213
           +NNN L  L   T ++L  L  + L+ NP  C C + W  A A  TRV   EP S  CA 
Sbjct: 342 LNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRW--ANATGTRVRFIEPQSTLCAE 399

Query: 214 PPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQ 273
           PP LQ +PV  +P        + L   P    P   + +G + VLHC A   P P + W 
Sbjct: 400 PPDLQRLPVREVPFREMTDHCLPL-ISPRSFPPSLQVASGESMVLHCRALAEPEPEIYW- 457

Query: 274 LQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFL 333
                                                     TP      PA  A  R+ 
Sbjct: 458 -----------------------------------------VTPAGLRLTPA-HAGRRYR 475

Query: 334 ALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
               G+L +  ++A+EAG+YTC A N +GA++ ++ V V
Sbjct: 476 VYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 14/193 (7%)

Query: 3   PLRALWLVWALLGVAG-----SCPEPCAC------VDKYAHQFA---DCAYKELREVPEG 48
           PL   W+  A   V        CP  CAC        + +++ A   DC    L  VP  
Sbjct: 7   PLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPA 66

Query: 49  LPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSH 108
           LPA   TL L +N I  + +     +  +T L L+ N            L QL +L L  
Sbjct: 67  LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126

Query: 109 NFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFD 168
           N ++         L++LQ L +NHN+L  +   A   L +L  L +N+N LR +    F+
Sbjct: 127 NQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFE 186

Query: 169 ALSALSHLQLYHN 181
            L  L  L +  N
Sbjct: 187 MLPNLEILMIGGN 199



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 5/155 (3%)

Query: 27  VDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNE 86
           +D   + F+D    +   +P+ L     +L L  N++T L   +FA +  +  L+L HN+
Sbjct: 98  LDLSQNSFSDARDCDFHALPQLL-----SLHLEENQLTRLEDHSFAGLASLQELYLNHNQ 152

Query: 87  VRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGAL 146
           +  + P A + LS L  L L+ N + +        L  L++L +  N++ ++       L
Sbjct: 153 LYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPL 212

Query: 147 PDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
            +LRSL +    LR ++    + L +L  L  Y N
Sbjct: 213 ANLRSLVLAGMNLREISDYALEGLQSLESLSFYDN 247



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 12/86 (13%)

Query: 537 GGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQV--VFSTKKEL------- 587
           G  A   +R+  G ++Y    L   T Y  CL +A    H Q+  V++  KE        
Sbjct: 566 GQGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEATSCHRAL 625

Query: 588 ---PSLLVIVAVSVFLLVLATVPLLG 610
              P L+ I+A++V LL       LG
Sbjct: 626 GDRPGLIAILALAVLLLAAGLAAHLG 651


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score =  107 bits (266), Expect = 5e-23
 Identities = 80/282 (28%), Positives = 115/282 (40%), Gaps = 52/282 (18%)

Query: 3   PLRALW--------LVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVT 54
           P RA W        L+W    VA +CP PCAC   Y      C ++ L  VP G+  +V 
Sbjct: 2   PKRAHWGALSVVLILLWGHPRVALACPHPCAC---YVPSEVHCTFRSLASVPAGIAKHVE 58

Query: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114
            ++L  N I  L   +FA +T++  L +  NE+ ++  GAL  LS L+    S+N +   
Sbjct: 59  RINLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVI 118

Query: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDA----- 169
               L+ LS L  L ++HN++  +   A   L  LR L +  N L  L P TF       
Sbjct: 119 TGQTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLD 178

Query: 170 ---LSALSHLQLYH------------------------NPFHCGCGLVWLQAWAASTRVS 202
              LS + HL L                          NP+ C C + W   W A +R  
Sbjct: 179 YFRLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGI 238

Query: 203 LPEPDSIA---------CASPPALQGVPVYRLPALPCAPPSV 235
           L      A         C SP  L    +++L  + C  PS+
Sbjct: 239 LKCKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSI 280



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 45/193 (23%), Positives = 74/193 (38%), Gaps = 33/193 (17%)

Query: 281 VVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPA--------TPRF 332
           +V  P     E D V    G+  G+   L       P    +W  P          T   
Sbjct: 571 LVQSPSTQPAEKDTVTI--GKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHV 628

Query: 333 LALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG---PPKHA--PGAGG- 386
             L NG+L +P +   ++G Y C A N+ GA+  ++ + V   G   P K    PGA   
Sbjct: 629 YMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRPGAKAL 688

Query: 387 --------EPDGQAPTSERKSTAK----GRGNSVLPSKPEGKIKG-----QGLAKVSILG 429
                   E +G +   + ++T++     +   V     +  I G     +G  K+ +  
Sbjct: 689 SRVREDIVEDEGGSGMGDEENTSRRLLHPKDQEVFLKTKDDAINGDKKAKKGRRKLKLWK 748

Query: 430 ETETEPEEDTSEG 442
            +E EPE + +EG
Sbjct: 749 HSEKEPETNVAEG 761



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 26/74 (35%), Positives = 33/74 (44%), Gaps = 9/74 (12%)

Query: 316  TPTPAPAWPAP---------PATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANST 366
            TP P  +W  P         P   R     N +L +   S  + GVY C A N  GA+S 
Sbjct: 1977 TPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSL 2036

Query: 367  SIRVAVAATGPPKH 380
            +IR+ VAA  P  H
Sbjct: 2037 AIRLHVAALPPVIH 2050



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 36/113 (31%)

Query: 260  CIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTP 319
            C+A G P P + W L  P G++V     +  +D G                         
Sbjct: 2265 CVATGLPNPEISWSL--PDGSLVNS--FMQSDDSG------------------------- 2295

Query: 320  APAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
                     T R++   NG+L    +  +E G YTC A N++G +   +RV V
Sbjct: 2296 -------GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 8/72 (11%)

Query: 309  LTQTQAQTPTPAPAWPAPPATP--------RFLALANGSLLVPLLSAKEAGVYTCRAHNE 360
            L  + A TPTP+  W  P  T         RF   A+G L +  LS+ +AG Y C A N 
Sbjct: 2562 LNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNA 2621

Query: 361  LGANSTSIRVAV 372
             G     + + V
Sbjct: 2622 AGHTERLVSLKV 2633



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 46/199 (23%), Positives = 68/199 (34%), Gaps = 61/199 (30%)

Query: 235  VHLSAEPPL----EAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ--------------- 275
            +H++A PP+    +     L  GL+  +HC A   P P ++W L                
Sbjct: 2040 LHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNL 2099

Query: 276  --IPGGTVVLE--PPVLSGEDDGVGAE-EGEGEGDGDLLTQTQAQT-------------- 316
               P GT+ +    P  SG  + V A   G       L  Q  A                
Sbjct: 2100 FVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVR 2159

Query: 317  --------------PTPAPAWPAPPAT---------PRFLALANGSLLVPLLSAKEAGVY 353
                          P P   W  P             R    ANG+L+V  ++ K+AG Y
Sbjct: 2160 YGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDY 2219

Query: 354  TCRAHNELGANSTSIRVAV 372
             C A N++G +   ++V V
Sbjct: 2220 LCVARNKVGDDYVVLKVDV 2238



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/52 (40%), Positives = 24/52 (46%)

Query: 326  PPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGP 377
            P    R   L NG+L V   S  + G Y CR   E G + TSI V V A  P
Sbjct: 2682 PQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 25/105 (23%), Positives = 44/105 (41%), Gaps = 14/105 (13%)

Query: 317  PTPAPAWPAPP------ATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRV 370
            P P   W +P       ++ ++    +G+LL+      ++G YTC   N  G +  ++ +
Sbjct: 2374 PMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWI 2433

Query: 371  AVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEG 415
             V    PPK      G P+   P +  +  A G    ++  K EG
Sbjct: 2434 HVNVQ-PPK----INGNPN---PITTVREIAAGGSRKLIDCKAEG 2470



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 9/101 (8%)

Query: 281  VVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW--------PAPPATPR 331
            V ++PP ++G  + +        G    L   +A+  PTP   W        PAP    R
Sbjct: 2435 VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494

Query: 332  FLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAV 372
                 NGSL +  L   ++    C A NE G     +++ V
Sbjct: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535


>gi|14149694 retina specific protein PAL [Homo sapiens]
          Length = 623

 Score =  105 bits (262), Expect = 2e-22
 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%)

Query: 6   ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54
           AL ++W LL +A      G CP  C+C      D    +   C   ++   P  +P + +
Sbjct: 4   ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62

Query: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114
            L L    I  +   AF  + ++  LWL +N +  +    L  L +L+ L L  N +++F
Sbjct: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122

Query: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174
           PW+ LR+   L+LL +  NRL ++P +A   L +L  L +++N+L  L     + + + +
Sbjct: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179

Query: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215
           HL+               L  NP+ C C L      L  WA +      E   + CASP 
Sbjct: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236

Query: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275
           +L GV   +L    C  P +H     P  A    L  G A +L C A G P P + W+  
Sbjct: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288

Query: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334
                                        +G  L  T   +  +   +W           
Sbjct: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312

Query: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394
                L +P +S  ++G Y C+A N LGA+ T I + V  T PP     +G      A T
Sbjct: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365

Query: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454
                 A      V    P+       + K ++L    T P   +++ E   +    D  
Sbjct: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415

Query: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514
            E   G   PS           A +   V  +G    D     + V   P A        
Sbjct: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453

Query: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572
                    +       L    G  +++   V+ G       GL P T Y  C+ + G  
Sbjct: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504

Query: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619
              E C   V+FST + + +     L+ +V +SV +++   +PL    CC  L K
Sbjct: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score =  104 bits (260), Expect = 3e-22
 Identities = 82/271 (30%), Positives = 121/271 (44%), Gaps = 14/271 (5%)

Query: 10  VWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69
           V  LL V  SCP+ C C  + +  F DC+ + L E+P  LP    TL L  N+I  L   
Sbjct: 11  VIVLLQVVCSCPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68

Query: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLK 129
           AF  V  + +L L++N +  + PGA   L  L+ L+L+ N + S       +L  L+ L 
Sbjct: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128

Query: 130 MNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL 189
           ++ N +  LP        +L  L +  N+L+ L     +++ ++  L L  N + C C L
Sbjct: 129 LSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHL 188

Query: 190 VWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP---ALPC---APPSVHLSAEPPL 243
           + L+ W           D I C SP   +G  + R+P     PC   AP  V   A+ P 
Sbjct: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248

Query: 244 EAPGTPLR------AGLAFVLHCIADGHPTP 268
            A G  LR      AG   +L C     P P
Sbjct: 249 SAHGVVLRPPENHNAGERELLECELKPKPRP 279


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 109/471 (23%), Positives = 171/471 (36%), Gaps = 130/471 (27%)

Query: 13  LLGVAGS---CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69
           L+G+A     CP+ C C     +    CA K L  VP  +      L L+ N +T ++R 
Sbjct: 10  LIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRK 69

Query: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLK--------------------------- 102
            FA++T +  L L+ N +  + P A A L  L+                           
Sbjct: 70  DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLI 129

Query: 103 ---------------------NLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRD 141
                                 LDLS+N + + PW  +  + +L  L ++HN + ++P+ 
Sbjct: 130 LNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKG 189

Query: 142 ALGALPDLRSLRINNNRLRTLAPG-TFDALSALS----------HLQLYHNPFHCGCGLV 190
               L  +  L + +N+L+ L P   F     L+           L    NP HC C L+
Sbjct: 190 TFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL 249

Query: 191 WLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP--ALPCAPPSV--HLSAEPPLEAP 246
           WL+      R+S  E D   CASPP L G   + +P     C PP +  H      LE  
Sbjct: 250 WLR------RLS-REDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE-- 300

Query: 247 GTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDG 306
                 G    L C A G P P + W          + P                   +G
Sbjct: 301 ------GQRATLRCKARGDPEPAIHW----------ISP-------------------EG 325

Query: 307 DLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANST 366
            L++                    R L   NG+L + + + K+ G +TC A N  G  + 
Sbjct: 326 KLISN-----------------ATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQ 368

Query: 367 SIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKI 417
            + + +       ++     EPD   P S   ST+   G++   S  + K+
Sbjct: 369 IVDLHIIKLPHLLNSTNHIHEPD---PGSSDISTSTKSGSNTSSSNGDTKL 416


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 61/182 (33%), Positives = 97/182 (53%), Gaps = 8/182 (4%)

Query: 3   PLRALWLVWALLGVAG-----SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLS 57
           PL  + L   LL VAG     +CP  C+C ++++     C  K LREVP+G+  N   L+
Sbjct: 25  PLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVI--CVRKNLREVPDGISTNTRLLN 82

Query: 58  LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWS 117
           L  N+I +++  +F  +  +  L L+ N +RT+E GA   L+ L  L+L  N +++ P  
Sbjct: 83  LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142

Query: 118 DLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINN-NRLRTLAPGTFDALSALSHL 176
               LS L+ L + +N + S+P  A   +P LR L +    RL  ++ G F+ LS L +L
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202

Query: 177 QL 178
            L
Sbjct: 203 NL 204



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 75/354 (21%), Positives = 127/354 (35%), Gaps = 112/354 (31%)

Query: 33  QFADCAYKELREVPEGLPA-NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVE 91
           ++ + A   LRE+P   P   +  L LS N ++ +R G+F  +  +  LW+  ++++ +E
Sbjct: 200 RYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIE 259

Query: 92  PGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRS 151
             A   L  L  ++L+HN ++  P      L  L+ + ++HN                  
Sbjct: 260 RNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN------------------ 301

Query: 152 LRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIAC 211
                                         P++C C ++WL  W     +    P + AC
Sbjct: 302 ------------------------------PWNCNCDILWLSWW-----IKDMAPSNTAC 326

Query: 212 A----SPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGH 265
                +PP L+G  +  L      C  P +    EPP +   T    G+A  L C A   
Sbjct: 327 CARCNTPPNLKGRYIGELDQNYFTCYAPVI---VEPPADLNVT---EGMAAELKCRASTS 380

Query: 266 PTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPA 325
            T  + W    P GTV+             GA +                          
Sbjct: 381 LT-SVSW--ITPNGTVMTH-----------GAYK-------------------------- 400

Query: 326 PPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG--ANSTSIRVAVAATGP 377
                R   L++G+L    ++ ++ G+YTC   N +G    S ++ V  A T P
Sbjct: 401 ----VRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTP 450


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 74/222 (33%), Positives = 94/222 (42%), Gaps = 36/222 (16%)

Query: 7   LWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVL 66
           L L  A    A  CP+ C C +   H    C Y+ L EVP+ +P     L L  N + V+
Sbjct: 20  LLLAPARQAAAQRCPQACICDNSRRH--VACRYQNLTEVPDAIPELTQRLDLQGNLLKVI 77

Query: 67  RRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQ 126
              AF  V  +T L L H EV  V  GA                         R L  L 
Sbjct: 78  PAAAFQGVPHLTHLDLRHCEVELVAEGA------------------------FRGLGRLL 113

Query: 127 LLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCG 186
           LL +  N L  LP++AL  L  LR L +  N L  L PGTF AL AL+ L L HN     
Sbjct: 114 LLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHN----- 168

Query: 187 CGLVWLQAWA----ASTRVSLPEPDSIACASPPALQGVPVYR 224
             LV+L A A       R      ++++  +P AL G+P  R
Sbjct: 169 -ALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALR 209



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 56/162 (34%), Positives = 76/162 (46%), Gaps = 2/162 (1%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           CP  C CV +  H  + C    L+ VP G P++   L L  N    + R AF  +  + S
Sbjct: 396 CPRACVCVPESRH--SSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVS 453

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
           L L H  +  +E GALA L +L  L LS N ++    + L     L  L +  NR   +P
Sbjct: 454 LHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVP 513

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
             AL ALP L SL + +N +  LAPG      AL  + L  N
Sbjct: 514 GAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 64/204 (31%), Positives = 85/204 (41%), Gaps = 26/204 (12%)

Query: 38  AYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAV 97
           A +ELR    G    + TL+L+ N +  L   AF  + +V  L L+HN +  + P ALA 
Sbjct: 145 ALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAG 204

Query: 98  LSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
           L  L+ L L HN + + P   L     L  L++ HN L     +   ALP LR L ++  
Sbjct: 205 LPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGG 264

Query: 158 RLRTLAPGTF----------------DAL------SALSHLQLYHNPFHCGCGLVWLQAW 195
            L+ L P  F                D L        L  L+L  NP  CGC    L  W
Sbjct: 265 ALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEW 324

Query: 196 AASTRVSLPEPDSIACASPPALQG 219
            A  RV        AC  P  L+G
Sbjct: 325 LARARVR----SDGACQGPRRLRG 344



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 54/164 (32%), Positives = 78/164 (47%), Gaps = 8/164 (4%)

Query: 58  LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWS 117
           LS N+IT +  GA     ++  L L  N++R V  GAL  L  L  L LS N + +    
Sbjct: 552 LSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDG 611

Query: 118 DLRNLS-ALQLLKMNHNRLGSLPRDALGAL-PDLRSLRINNNRLRTLAPGTFDALSALSH 175
             + +  +LQ L +N + L  +   A   L P L+SL +  N+LR L      +LS L  
Sbjct: 612 AFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLEL 669

Query: 176 LQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG 219
           + L  NPFHC C L+ L  W     + +       CA+PP  +G
Sbjct: 670 IDLSSNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPNARG 709


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 2/219 (0%)

Query: 8   WLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 67
           W+    +    +CP  C C  +      DC+   L  VP  +PA   TL L  NK++ L 
Sbjct: 27  WIALYAVEALPTCPFSCKCDSRSLE--VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALP 84

Query: 68  RGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQL 127
             AFA+++ +  L L++N +  +       L+ L  L L +N I +     LR+   L+ 
Sbjct: 85  SWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRH 144

Query: 128 LKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGC 187
           L ++ N L  LP      L  LRSL + +NRL+ L   TF+ L+ L  LQ+  NP+ C C
Sbjct: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 204

Query: 188 GLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP 226
            L   + W           D +AC  P  L+G  +  +P
Sbjct: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVP 243


>gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265

Query: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325

Query: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385

Query: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445

Query: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504

Query: 255 AF 256
            F
Sbjct: 505 VF 506


>gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 90/302 (29%), Positives = 117/302 (38%), Gaps = 50/302 (16%)

Query: 4   LRALWLVWALLGV-AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANK 62
           L+ L LV A L   A  CP  C C           +  ELR+ P  +P +   L++    
Sbjct: 206 LQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGAN 265

Query: 63  ITVLRRGAFAD------------VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNF 110
           +TVLR  AFA             +  +++L L HN +  VE GA   L  L  LDLSHN 
Sbjct: 266 LTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325

Query: 111 ISSFPWSDLRNLSALQLLKMNHNRLGSLPR------DALGALPDLRSLRINNNRLRTLAP 164
           + +      R L AL+ L++NH  +   P        AL  L +LR L +  N L  L P
Sbjct: 326 LRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPP 385

Query: 165 GTF--------------------DALSALS--------HLQLYHNPFHCGCGLVWLQAWA 196
                                  D L AL          L L  NP  CGC    L AW 
Sbjct: 386 AALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWL 445

Query: 197 ASTRVSLPEPDSIACASPPALQGVPVYRLPA--LPCAPPSVHLSAEPPLEAPGTPLRAGL 254
            +    +P+   + CA+P AL   P+  L    L CA        E   EA G  L A  
Sbjct: 446 RNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGE-EAEAAGPELEASY 504

Query: 255 AF 256
            F
Sbjct: 505 VF 506


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 67/188 (35%), Positives = 88/188 (46%), Gaps = 3/188 (1%)

Query: 52  NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFI 111
           N+T LSL  N + VL  G FA    +  L L HN++ TV  G  A LS L++L LS+N I
Sbjct: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325

Query: 112 SSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALS 171
           +  P    R+L  L  L +  N L +L       L  L  L ++ N+L TL  G FD   
Sbjct: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNY 385

Query: 172 ALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG--VPVYRLPALP 229
            L +L L+ NP+ C C L +L  W       L    +  CA P  L+G  VP      L 
Sbjct: 386 NLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY-CAGPAYLKGQVVPALNEKQLV 444

Query: 230 CAPPSVHL 237
           C     HL
Sbjct: 445 CPVTRDHL 452



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 39/126 (30%), Positives = 64/126 (50%)

Query: 56  LSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFP 115
           L+L+ N +  L  G F  +  + SL L  N+++ +       L+ LK L+L+ N ++  P
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185

Query: 116 WSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSH 175
                 L++LQ LK+++N L  LP+   G L  L+ L +++N +  L P  F  L  L  
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245

Query: 176 LQLYHN 181
           L L  N
Sbjct: 246 LWLQRN 251



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 48/143 (33%), Positives = 69/143 (48%), Gaps = 3/143 (2%)

Query: 42  LREVPEGLPANVT---TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
           L ++PE L   +T   TL LS N ++ L +G F  +  +  L+L  N +  + P   + L
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240

Query: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNR 158
             L+ L L  N I+  P S   +L  L  L +  N L  LP       P L  L + +N+
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300

Query: 159 LRTLAPGTFDALSALSHLQLYHN 181
           L T+A GTF  LS L  L L +N
Sbjct: 301 LETVAEGTFAHLSNLRSLMLSYN 323



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 46/178 (25%), Positives = 75/178 (42%)

Query: 4   LRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKI 63
           L   WL+W  L +     +PC        Q   C+ +EL  VP  +P     +       
Sbjct: 2   LPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSF 61

Query: 64  TVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLS 123
           T L   AF     +T +   + ++    P A   L +L++L+++ +   +   +   NL+
Sbjct: 62  TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLT 121

Query: 124 ALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181
           +L  L +N N L +LP      L  L SL +  N+L+ L    F  L+ L  L L  N
Sbjct: 122 SLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 3/146 (2%)

Query: 39  YKELREVPEGL---PANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGAL 95
           +  L  +PEGL    A + +L L  N++  L R  F  +T + +L LA N +  +     
Sbjct: 130 FNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELF 189

Query: 96  AVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN 155
             L+ L+ L LS+N +S  P      L +LQ L ++ N +  LP      L  L  L + 
Sbjct: 190 HPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQ 249

Query: 156 NNRLRTLAPGTFDALSALSHLQLYHN 181
            N +  L    F +L  L+ L L  N
Sbjct: 250 RNAITHLPLSIFASLGNLTFLSLQWN 275



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 1/134 (0%)

Query: 48  GLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLS 107
           GLP  +  L ++ +    L    F+++T +  L L  N +  +  G    L+ L++L L 
Sbjct: 95  GLP-RLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQ 153

Query: 108 HNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTF 167
            N + + P    + L+ L+ L +  N L  LP +    L  L++L+++NN L  L  G F
Sbjct: 154 GNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVF 213

Query: 168 DALSALSHLQLYHN 181
             L +L  L L  N
Sbjct: 214 GKLGSLQELFLDSN 227



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 39/130 (30%), Positives = 58/130 (44%)

Query: 52  NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFI 111
           ++ TL+L+ N +  L    F  +T + +L L++N +  +  G    L  L+ L L  N I
Sbjct: 170 HLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNI 229

Query: 112 SSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALS 171
           S  P      L  L+ L +  N +  LP     +L +L  L +  N LR L  G F    
Sbjct: 230 SELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTP 289

Query: 172 ALSHLQLYHN 181
            L  L L HN
Sbjct: 290 CLVGLSLTHN 299


>gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
          Length = 1321

 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 63/212 (29%), Positives = 99/212 (46%), Gaps = 36/212 (16%)

Query: 37  CAYKELREV--PEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGA 94
           C+  EL +V  P+ LP    TL LS NKI+ L+ G+F+ ++ +  L L +N + +++PGA
Sbjct: 65  CSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGA 124

Query: 95  LAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRI 154
              LS LK LDL++N                        R+G L  D    L +L  L +
Sbjct: 125 FWGLSSLKRLDLTNN------------------------RIGCLNADIFRGLTNLVRLNL 160

Query: 155 NNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASP 214
           + N   +L+ GTFD L++L  L+       C C ++W+  W     +++ +     C  P
Sbjct: 161 SGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNITVRD---TRCVYP 217

Query: 215 PALQGVPVYRLPALPCAPPSVHLSAEPPLEAP 246
            +LQ  PV              L+ +PPLE P
Sbjct: 218 KSLQAQPV-------TGVKQELLTCDPPLELP 242


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 64/181 (35%), Positives = 90/181 (49%), Gaps = 10/181 (5%)

Query: 8   WLVWALLGVAGS-------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA 60
           +L   LLG AG        C  PC+C      +  DC+ K L  VPEGL A    L +S 
Sbjct: 10  FLALGLLGSAGPSGAAPPLCAAPCSCD---GDRRVDCSGKGLTAVPEGLSAFTQALDISM 66

Query: 61  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR 120
           N IT L   AF +   +  L LA N++  + P AL+ L +LK L L +N + + P   +R
Sbjct: 67  NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126

Query: 121 NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH 180
            LSALQ L+++ N + S+P D+   L  LR L +++N L  +       L  L  L L  
Sbjct: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLAL 186

Query: 181 N 181
           N
Sbjct: 187 N 187



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 30/170 (17%)

Query: 41  ELREVPE----GLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALA 96
           +L+ VP     GL A + +L L AN IT +   +F  + Q+  LWL  N +  V    L+
Sbjct: 116 QLKTVPSEAIRGLSA-LQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLS 174

Query: 97  VLSQLKNLDLSHNFISSFPWSDLRNLSA------------------------LQLLKMNH 132
            L  L+ L L+ N ISS P     NLS+                        L+ L +N+
Sbjct: 175 NLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNY 234

Query: 133 NRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNP 182
           N LG  P+ A+ ALP L+ L  ++N +  +  G FD    L  + LY NP
Sbjct: 235 NNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 31/105 (29%), Positives = 55/105 (52%), Gaps = 3/105 (2%)

Query: 26  CVDKYAHQFADCAYKELREVPE--GLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLA 83
           C ++   +  D +Y  +R++P   G  A +  +SL  N+I  ++ G F  +  +  L L+
Sbjct: 339 CQEQKMLRTLDLSYNNIRDLPSFNGCHA-LEEISLQRNQIYQIKEGTFQGLISLRILDLS 397

Query: 84  HNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLL 128
            N +  +   A A L  + NLD+S N ++SFP   L  L+ L+L+
Sbjct: 398 RNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLV 442



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/174 (24%), Positives = 70/174 (40%), Gaps = 27/174 (15%)

Query: 36  DCAYKELREVPEGLPA--NVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPG 93
           D  Y  L E P+ + A  ++  L   +N I+V+  GAF     + ++ L  N +  V   
Sbjct: 231 DLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNS 290

Query: 94  ALAVLSQL-----------------------KNLDLSHNFISSFPWSDLRNLSALQLLKM 130
           A   LS L                       ++L L+   ISS P +  +    L+ L +
Sbjct: 291 AFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350

Query: 131 NHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFH 184
           ++N +  LP  +      L  + +  N++  +  GTF  L +L  L L  N  H
Sbjct: 351 SYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 39/134 (29%), Positives = 56/134 (41%), Gaps = 5/134 (3%)

Query: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114
           TL LS N I  L   +F     +  + L  N++  ++ G    L  L+ LDLS N I   
Sbjct: 347 TLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404

Query: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR-TLAPGTFDALSAL 173
                  L  +  L ++ N L S P + L  L  L+   + N +L+  LA   F  L +L
Sbjct: 405 HSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK--LVGNFKLKEALAAKDFVNLRSL 462

Query: 174 SHLQLYHNPFHCGC 187
           S    Y      GC
Sbjct: 463 SVPYAYQCCAFWGC 476


>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
          Length = 550

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 85/380 (22%), Positives = 146/380 (38%), Gaps = 67/380 (17%)

Query: 20  CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
           C   C C ++   +   C    L ++P  L      + +  + +  + +G+F +++ +  
Sbjct: 24  CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83

Query: 80  LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
           LWL  N +  +  GAL  L +L+ L L  N + S PW+  R    L++L +  N++ +LP
Sbjct: 84  LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143

Query: 140 RDALGALPDLRSLRINNNRLRTLAPGTF----------------DALSALSHLQLYHNPF 183
             AL  L  L  L +++NRL  ++   F                + LS+L  + L+ NP+
Sbjct: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV-VALHDNPW 202

Query: 184 HCGCGLVWLQAWAASTRVSLPEPDS-IACASPPALQGVPVYRLPALPCAPPSVHLSAEPP 242
            C C L  L  +  S  + +   +S + C  P +  G   +      C  P +       
Sbjct: 203 VCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQI------S 256

Query: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEG 302
             +    +RAG    L C+A   P+P + W            P  +  E D + +  GE 
Sbjct: 257 TPSANITIRAGQNVTLRCLAQASPSPSIAWTY----------PLSMWREFDVLTSSTGED 306

Query: 303 EGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG 362
                                            A   L +P     ++G YTC A N +G
Sbjct: 307 --------------------------------TALSELAIPAAHLVDSGNYTCMASNSIG 334

Query: 363 ANSTSIRVAVAATGPPKHAP 382
            ++  I + V       HAP
Sbjct: 335 KSNLVISLHV-QPAQALHAP 353



 Score = 33.5 bits (75), Expect = 0.74
 Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 8/67 (11%)

Query: 549 GVNAYWFRGLRPGTNYSVCLALAGEACHVQ--VVFSTKKELPSL-----LVIVAVSVFLL 601
           G+N Y    L PGT Y  CL+L G+  H    V F T ++   L     L+ V V V  +
Sbjct: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTV-VLCV 472

Query: 602 VLATVPL 608
           VL  VP+
Sbjct: 473 VLLAVPV 479


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,170,658
Number of Sequences: 37866
Number of extensions: 2019025
Number of successful extensions: 13500
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 269
Number of HSP's successfully gapped in prelim test: 369
Number of HSP's that attempted gapping in prelim test: 10165
Number of HSP's gapped (non-prelim): 2777
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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