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Search of human proteins with 113420453
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 1 [Homo sapiens]
(2796 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c... 5568 0.0
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [... 5475 0.0
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c... 4524 0.0
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 119 4e-26
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 109 4e-23
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 109 4e-23
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 99 8e-20
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 99 8e-20
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 99 8e-20
gi|222352183 neural precursor cell expressed, developmentally do... 97 2e-19
gi|21361472 neural precursor cell expressed, developmentally dow... 97 2e-19
gi|222352094 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352092 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352090 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352088 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352086 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352084 neural precursor cell expressed, developmentally do... 97 2e-19
gi|222352082 neural precursor cell expressed, developmentally do... 97 2e-19
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 96 4e-19
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 96 4e-19
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 96 5e-19
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 96 6e-19
gi|114520609 neural precursor cell expressed, developmentally do... 93 3e-18
gi|114520607 neural precursor cell expressed, developmentally do... 93 3e-18
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 91 1e-17
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 91 2e-17
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 85 9e-16
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 84 3e-15
gi|126032348 hect domain and RLD 2 [Homo sapiens] 82 7e-15
gi|157738609 HECT domain containing 3 [Homo sapiens] 77 2e-13
>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 1 [Homo sapiens]
Length = 2796
Score = 5568 bits (14444), Expect = 0.0
Identities = 2796/2796 (100%), Positives = 2796/2796 (100%)
Query: 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVFQQATIKQCVVGPNHAAF 60
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVFQQATIKQCVVGPNHAAF
Sbjct: 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVFQQATIKQCVVGPNHAAF 60
Query: 61 LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
Sbjct: 61 LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
Query: 121 GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
Sbjct: 121 GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
Query: 181 PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
Sbjct: 181 PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
Query: 241 SYLAGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
SYLAGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
Sbjct: 241 SYLAGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
Query: 301 LERDSELLRERESVLRLRERRWLDGASFDNERGSTKQGRRAKLDKKNTPVQSPVSLGEDL 360
LERDSELLRERESVLRLRERRWLDGASFDNERGSTKQGRRAKLDKKNTPVQSPVSLGEDL
Sbjct: 301 LERDSELLRERESVLRLRERRWLDGASFDNERGSTKQGRRAKLDKKNTPVQSPVSLGEDL 360
Query: 361 QWWPDKDGTKFICMALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTN 420
QWWPDKDGTKFICMALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTN
Sbjct: 361 QWWPDKDGTKFICMALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTN 420
Query: 421 EKIVLLSANSIRATVATEKNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCAL 480
EKIVLLSANSIRATVATEKNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCAL
Sbjct: 421 EKIVLLSANSIRATVATEKNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCAL 480
Query: 481 YTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPL 540
YTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPL
Sbjct: 481 YTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPL 540
Query: 541 YHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQE 600
YHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQE
Sbjct: 541 YHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQE 600
Query: 601 PVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVED 660
PVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVED
Sbjct: 601 PVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVED 660
Query: 661 VKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKT 720
VKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKT
Sbjct: 661 VKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKT 720
Query: 721 GGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQE 780
GGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQE
Sbjct: 721 GGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQE 780
Query: 781 NNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPI 840
NNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPI
Sbjct: 781 NNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPI 840
Query: 841 SSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLE 900
SSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLE
Sbjct: 841 SSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLE 900
Query: 901 QNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAI 960
QNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAI
Sbjct: 901 QNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAI 960
Query: 961 ANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIA 1020
ANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIA
Sbjct: 961 ANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIA 1020
Query: 1021 PPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRK 1080
PPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRK
Sbjct: 1021 PPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRK 1080
Query: 1081 ANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKA 1140
ANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKA
Sbjct: 1081 ANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKA 1140
Query: 1141 EISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLL 1200
EISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLL
Sbjct: 1141 EISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLL 1200
Query: 1201 ESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTAT 1260
ESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTAT
Sbjct: 1201 ESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTAT 1260
Query: 1261 NLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPP 1320
NLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPP
Sbjct: 1261 NLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPP 1320
Query: 1321 RFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDC 1380
RFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDC
Sbjct: 1321 RFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDC 1380
Query: 1381 FTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVE 1440
FTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVE
Sbjct: 1381 FTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVE 1440
Query: 1441 MASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLAST 1500
MASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLAST
Sbjct: 1441 MASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLAST 1500
Query: 1501 SIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQD 1560
SIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQD
Sbjct: 1501 SIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQD 1560
Query: 1561 DIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAET 1620
DIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAET
Sbjct: 1561 DIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAET 1620
Query: 1621 ESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSD 1680
ESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSD
Sbjct: 1621 ESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSD 1680
Query: 1681 DIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSA 1740
DIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSA
Sbjct: 1681 DIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSA 1740
Query: 1741 GLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLI 1800
GLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLI
Sbjct: 1741 GLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLI 1800
Query: 1801 PKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASA 1860
PKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASA
Sbjct: 1801 PKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASA 1860
Query: 1861 GDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYAL 1920
GDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYAL
Sbjct: 1861 GDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYAL 1920
Query: 1921 SLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLE 1980
SLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLE
Sbjct: 1921 SLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLE 1980
Query: 1981 LGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEV 2040
LGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEV
Sbjct: 1981 LGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEV 2040
Query: 2041 PLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKM 2100
PLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKM
Sbjct: 2041 PLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKM 2100
Query: 2101 SYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESE 2160
SYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESE
Sbjct: 2101 SYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESE 2160
Query: 2161 GPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 2220
GPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE
Sbjct: 2161 GPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKE 2220
Query: 2221 SKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFK 2280
SKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFK
Sbjct: 2221 SKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFK 2280
Query: 2281 DEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRERER 2340
DEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRERER
Sbjct: 2281 DEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRERER 2340
Query: 2341 EREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLY 2400
EREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLY
Sbjct: 2341 EREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLY 2400
Query: 2401 PRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARVDEAMELIIAHGRENGADSILD 2460
PRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARVDEAMELIIAHGRENGADSILD
Sbjct: 2401 PRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARVDEAMELIIAHGRENGADSILD 2460
Query: 2461 LGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTE 2520
LGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTE
Sbjct: 2461 LGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTE 2520
Query: 2521 ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLI 2580
ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLI
Sbjct: 2521 ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLI 2580
Query: 2581 LASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRM 2640
LASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRM
Sbjct: 2581 LASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRM 2640
Query: 2641 LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGEN 2700
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGEN
Sbjct: 2641 LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGEN 2700
Query: 2701 AEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLP 2760
AEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLP
Sbjct: 2701 AEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLP 2760
Query: 2761 TANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2796
TANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Sbjct: 2761 TANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2796
>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
sapiens]
Length = 2799
Score = 5475 bits (14204), Expect = 0.0
Identities = 2759/2799 (98%), Positives = 2770/2799 (98%), Gaps = 3/2799 (0%)
Query: 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVFQQATIKQCVVGPNHAAF 60
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNV +QATIKQCVVGPNHAAF
Sbjct: 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF 60
Query: 61 LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
Sbjct: 61 LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
Query: 121 GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
Sbjct: 121 GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
Query: 181 PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
Sbjct: 181 PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
Query: 241 SYLAGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
SYL GEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
Sbjct: 241 SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
Query: 301 LERDSELLRERESVLRLRERRWLDGASFDNERGSTKQGRRAKLDKKNTPVQSPVSLGEDL 360
LERDSELLRERESVLRLRERRWLDGASFDNERGST + LDKKNTPVQSPVSLGEDL
Sbjct: 301 LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL 360
Query: 361 QWWPDKDGTKFICM-ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 419
QWWPDKDGTKFIC+ ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
Sbjct: 361 QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 420
Query: 420 NEKIVLLSANSIRATVATEKNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 479
NEKIVLLSANSIRATVATE NKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
Sbjct: 421 NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 480
Query: 480 LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 539
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
Sbjct: 481 LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 540
Query: 540 LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 599
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
Sbjct: 541 LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 600
Query: 600 EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 659
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
Sbjct: 601 EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 660
Query: 660 DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 719
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
Sbjct: 661 DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 720
Query: 720 TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 779
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
Sbjct: 721 TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 780
Query: 780 ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 839
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
Sbjct: 781 ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 840
Query: 840 ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRF- 898
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQ
Sbjct: 841 ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV 900
Query: 899 LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 958
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
Sbjct: 901 LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 960
Query: 959 AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1018
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
Sbjct: 961 AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1020
Query: 1019 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1078
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
Sbjct: 1021 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1080
Query: 1079 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1138
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
Sbjct: 1081 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1140
Query: 1139 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1198
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
Sbjct: 1141 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1200
Query: 1199 LLESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1258
LLESLCCCTECA VCHKGHD KLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
Sbjct: 1201 LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1260
Query: 1259 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1318
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
Sbjct: 1261 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1320
Query: 1319 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1378
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
Sbjct: 1321 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1380
Query: 1379 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1438
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
Sbjct: 1381 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1440
Query: 1439 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1498
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
Sbjct: 1441 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1500
Query: 1499 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1558
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
Sbjct: 1501 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1560
Query: 1559 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1618
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
Sbjct: 1561 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1620
Query: 1619 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1678
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
Sbjct: 1621 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1680
Query: 1679 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAAS 1738
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNT HQRAASTAPSSTSTPAAS
Sbjct: 1681 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS 1740
Query: 1739 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSMSLDKSSDLMG 1798
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYS+ + + SDLMG
Sbjct: 1741 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG 1800
Query: 1799 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1858
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
Sbjct: 1801 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1860
Query: 1859 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1918
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
Sbjct: 1861 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1920
Query: 1919 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1978
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
Sbjct: 1921 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1980
Query: 1979 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2038
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
Sbjct: 1981 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2040
Query: 2039 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2098
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
Sbjct: 2041 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2100
Query: 2099 KMSYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2158
KMSYAANLKNVMNMQNRQKK+G+EQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
Sbjct: 2101 KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2160
Query: 2159 SEGPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2218
SEGPPLTSFRPQCSFMGMV+SHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
Sbjct: 2161 SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2220
Query: 2219 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVT 2278
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT PMAVHRVKVT
Sbjct: 2221 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT 2280
Query: 2279 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2338
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
Sbjct: 2281 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2340
Query: 2339 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2398
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
Sbjct: 2341 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2400
Query: 2399 LYPRVQAMQPAFASKITGMLLDY-PSSAASLLASEDSLRARVDEAMELIIAHGRENGADS 2457
LYPRVQAMQPAFASKITGMLL+ P+ LLASEDSLRARVDEAMELIIAHGRENGADS
Sbjct: 2401 LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS 2460
Query: 2458 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2517
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
Sbjct: 2461 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2520
Query: 2518 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2577
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
Sbjct: 2521 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2580
Query: 2578 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAE 2637
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGV PVTPQNVYEYVRK AE
Sbjct: 2581 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 2640
Query: 2638 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2697
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
Sbjct: 2641 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2700
Query: 2698 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2757
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
Sbjct: 2701 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2760
Query: 2758 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2796
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Sbjct: 2761 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799
>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 2 [Homo sapiens]
Length = 2277
Score = 4524 bits (11735), Expect = 0.0
Identities = 2277/2293 (99%), Positives = 2277/2293 (99%), Gaps = 16/2293 (0%)
Query: 504 MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 563
MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES
Sbjct: 1 MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60
Query: 564 VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 623
VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
Sbjct: 61 VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120
Query: 624 SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 683
SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG
Sbjct: 121 SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180
Query: 684 TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 743
TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT
Sbjct: 181 TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240
Query: 744 EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 803
EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA
Sbjct: 241 EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300
Query: 804 GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 863
GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA
Sbjct: 301 GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360
Query: 864 AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 923
AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA
Sbjct: 361 AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 420
Query: 924 CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 983
CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS
Sbjct: 421 CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 480
Query: 984 LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAP 1043
LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD
Sbjct: 481 LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD--------- 531
Query: 1044 AVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL 1103
AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL
Sbjct: 532 -------AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL 584
Query: 1104 LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP 1163
LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP
Sbjct: 585 LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP 644
Query: 1164 DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR 1223
DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR
Sbjct: 645 DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR 704
Query: 1224 TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR 1283
TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR
Sbjct: 705 TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR 764
Query: 1284 QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF 1343
QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF
Sbjct: 765 QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF 824
Query: 1344 GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL 1403
GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL
Sbjct: 825 GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL 884
Query: 1404 VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ 1463
VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ
Sbjct: 885 VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ 944
Query: 1464 ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS 1523
ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS
Sbjct: 945 ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS 1004
Query: 1524 DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH 1583
DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH
Sbjct: 1005 DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH 1064
Query: 1584 DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA 1643
DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA
Sbjct: 1065 DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA 1124
Query: 1644 ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN 1703
ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN
Sbjct: 1125 ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN 1184
Query: 1704 GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA 1763
GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA
Sbjct: 1185 GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA 1244
Query: 1764 AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV 1823
AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV
Sbjct: 1245 AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV 1304
Query: 1824 NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT 1883
NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT
Sbjct: 1305 NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT 1364
Query: 1884 AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK 1943
AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK
Sbjct: 1365 AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK 1424
Query: 1944 HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN 2003
HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN
Sbjct: 1425 HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN 1484
Query: 2004 DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED 2063
DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED
Sbjct: 1485 DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED 1544
Query: 2064 LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ 2123
LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ
Sbjct: 1545 LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ 1604
Query: 2124 PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML 2183
PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML
Sbjct: 1605 PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML 1664
Query: 2184 LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD 2243
LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD
Sbjct: 1665 LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD 1724
Query: 2244 RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS 2303
RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS
Sbjct: 1725 RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS 1784
Query: 2304 NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR 2363
NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR
Sbjct: 1785 NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR 1844
Query: 2364 RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS 2423
RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS
Sbjct: 1845 RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS 1904
Query: 2424 SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS 2483
SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS
Sbjct: 1905 SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS 1964
Query: 2484 VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC 2543
VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC
Sbjct: 1965 VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC 2024
Query: 2544 PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL 2603
PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL
Sbjct: 2025 PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL 2084
Query: 2604 CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS 2663
CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS
Sbjct: 2085 CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS 2144
Query: 2664 LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER 2723
LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER
Sbjct: 2145 LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER 2204
Query: 2724 QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK 2783
QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK
Sbjct: 2205 QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK 2264
Query: 2784 LLLAIKTKNFGFV 2796
LLLAIKTKNFGFV
Sbjct: 2265 LLLAIKTKNFGFV 2277
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 119 bits (298), Expect = 4e-26
Identities = 93/299 (31%), Positives = 145/299 (48%), Gaps = 23/299 (7%)
Query: 2503 YQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW 2562
+QP + P LN FR G+ILGL L +L I R K +LG VN+
Sbjct: 625 FQPNSNSYVNPD-------HLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNY 677
Query: 2563 HDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRP 2622
D A DP ++L Q IL + SD ++L F+++ +V L P G
Sbjct: 678 QDVASIDPEYAKNL-QWILDNDISDL-----GLELTFSVETDVFGAMEEVPLKPGGGSIL 731
Query: 2623 VTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2682
VT N EYV+ E RM + ++A +G +P + ++ + LL++G E+
Sbjct: 732 VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791
Query: 2683 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2738
+V I T + E + ++Q WFW +VE ++ ER L+ F T S +P A
Sbjct: 792 DVSDWIKNTEYTS-GYEREDPVIQ---WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 847
Query: 2739 SEEGFQPMPSITIR--PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2795
+ G + + TI P LPT++TCI+ L +P Y SK+ILK +LL+A+ ++G+
Sbjct: 848 NIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 109 bits (272), Expect = 4e-23
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 20/299 (6%)
Query: 2505 PGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH 2563
PG R YT P + L+ F+ +GRI+ + N L R K +LG+ V +
Sbjct: 4085 PGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT 4144
Query: 2564 DFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPNGVKRP 2622
D D Y+ L L+ + D DL F+ ++ +E G +V +L PNG
Sbjct: 4145 DMESEDYHFYQGLVYLL------ENDVSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANIL 4197
Query: 2623 VTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2682
VT +N EYV + RM + L A +G +++PK + T ++ LL++G +
Sbjct: 4198 VTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4257
Query: 2683 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2738
++ L S T ++ + + +WFW + +R + F T + +P A
Sbjct: 4258 DIDDLKSNTEYHKYQSNSIQ-----IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFA 4312
Query: 2739 SEEGFQPMPSITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2795
+ EG + I D LP+A+TC ++L +P Y S + L+ LLLAI+ + GF
Sbjct: 4313 ALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4371
Score = 45.8 bits (107), Expect = 6e-04
Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 14/106 (13%)
Query: 1508 SEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADV 1567
S+E ++ P S + +++ S I+ + +Q + G +E++DD S D
Sbjct: 2377 SQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDD--SQDE 2434
Query: 1568 EEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELD 1613
EE E EED D+QE+ E EG D+ D+DGS+MELD
Sbjct: 2435 EEEE-------EEDEEDDQEDDEGE----EGDEDD-DDDGSEMELD 2468
Score = 40.4 bits (93), Expect = 0.025
Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 18/184 (9%)
Query: 1511 LFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEV 1570
LF + + S+Q + + SS ++P + ++ Q EE D+ +V +
Sbjct: 2263 LFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQ------EEDHDVTQTEVADG 2316
Query: 1571 EVVEG--------VAGEEDHHDEQEEHGEENAEAEGQHDEH-DEDGSDMELDLLAAAETE 1621
++++G +AG+ + QE E E E DE + DG ++ + E
Sbjct: 2317 DIMDGEAETDSVVIAGQPEVLSSQEMQVEN--ELEDLIDELLERDGGSGNSTIIVSRSGE 2374
Query: 1622 SDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDD 1681
+S+ + D A S + A E + + E+ +Q DSS S+ S D
Sbjct: 2375 DESQEDVL-MDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQD 2433
Query: 1682 IEQE 1685
E+E
Sbjct: 2434 EEEE 2437
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 109 bits (272), Expect = 4e-23
Identities = 84/294 (28%), Positives = 138/294 (46%), Gaps = 23/294 (7%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQN-------ELCPITLNRHVIKVLLGRKVNWHDF 2565
P P + RL + GR++G CL ++ +L R + ++G ++++ F
Sbjct: 539 PNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYF 598
Query: 2566 AFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEG--GGQVELIPNGVKRPV 2623
DP Y+S IL + S+ M+L FA + + G VEL+ G + PV
Sbjct: 599 ETDDPEFYKSKVCFILNNDMSE-------MELVFAEEKYNKSGQLDKVVELMTGGAQTPV 651
Query: 2624 TPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVN 2683
T N Y+ A++R+ ++ + KGL +++P+N L + LL+ G G+++
Sbjct: 652 TNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDIS 711
Query: 2684 VQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGF 2743
V + S EK++ RWFW++V ++ E L+ F T S LP GF
Sbjct: 712 VSDFKAHAVVVGGSWHFREKVM---RWFWTVVSSLTQEELARLLQFTTGSSQLPPG--GF 766
Query: 2744 QPM-PSI-TIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2795
+ PS I P LPTA+TC ++L +P Y S + + + L LAI GF
Sbjct: 767 AALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 98.6 bits (244), Expect = 8e-20
Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)
Query: 2439 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2498
+D+A+ + EN AD L + E+ E G S+ + +++ + D
Sbjct: 530 IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 585
Query: 2499 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2558
+ + K ++ P + TE + F IG +LGL + N + + V + L+G+
Sbjct: 586 MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 641
Query: 2559 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2617
K + D PV+Y+SL+ L+ + + D M + F I G + +L N
Sbjct: 642 KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 696
Query: 2618 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2676
G K P+T +N E+V +++ + E+ A R+G V ++ L+ L E+ LL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 2677 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2736
G ++ Q L T + + G + +L R FW IV + +++ + F T +
Sbjct: 757 CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 812
Query: 2737 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2795
P G M I PD + LPT++TC + L +P YSSK+ LK++LL AI K FG
Sbjct: 813 PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 871
Query: 2796 V 2796
+
Sbjct: 872 L 872
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 98.6 bits (244), Expect = 8e-20
Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)
Query: 2439 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2498
+D+A+ + EN AD L + E+ E G S+ + +++ + D
Sbjct: 510 IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 565
Query: 2499 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2558
+ + K ++ P + TE + F IG +LGL + N + + V + L+G+
Sbjct: 566 MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 621
Query: 2559 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2617
K + D PV+Y+SL+ L+ + + D M + F I G + +L N
Sbjct: 622 KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 676
Query: 2618 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2676
G K P+T +N E+V +++ + E+ A R+G V ++ L+ L E+ LL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 2677 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2736
G ++ Q L T + + G + +L R FW IV + +++ + F T +
Sbjct: 737 CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 792
Query: 2737 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2795
P G M I PD + LPT++TC + L +P YSSK+ LK++LL AI K FG
Sbjct: 793 PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 851
Query: 2796 V 2796
+
Sbjct: 852 L 852
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 98.6 bits (244), Expect = 8e-20
Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)
Query: 2439 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2498
+D+A+ + EN AD L + E+ E G S+ + +++ + D
Sbjct: 533 IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 588
Query: 2499 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2558
+ + K ++ P + TE + F IG +LGL + N + + V + L+G+
Sbjct: 589 MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 644
Query: 2559 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2617
K + D PV+Y+SL+ L+ + + D M + F I G + +L N
Sbjct: 645 KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 699
Query: 2618 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2676
G K P+T +N E+V +++ + E+ A R+G V ++ L+ L E+ LL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 2677 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2736
G ++ Q L T + + G + +L R FW IV + +++ + F T +
Sbjct: 760 CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 815
Query: 2737 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2795
P G M I PD + LPT++TC + L +P YSSK+ LK++LL AI K FG
Sbjct: 816 PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
Query: 2796 V 2796
+
Sbjct: 875 L 875
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 636 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 685 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 745 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 677 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 736
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 737 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 785
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 786 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 845
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 846 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 902 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 946
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 616 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 665 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 725 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 616 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 665 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 725 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 669 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 728
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 729 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 777
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 778 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 837
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 838 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 894 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 938
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 689 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 748
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 749 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 797
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 798 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 857
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 858 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 913
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 914 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 958
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 697 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 756
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 757 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 805
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 806 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 865
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 866 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 921
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 922 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 966
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 636 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 685 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 745 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 97.4 bits (241), Expect = 2e-19
Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F IGR+ GL + +L R K++LG+++ +D D
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2629
Y SL+ ++ + +DL F ID EE GQ V+L PNG + VT +N
Sbjct: 636 YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ ++A +G ++LP + ++ + LL+ G G+V+V
Sbjct: 685 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
+ + + N + +WFW V M +R L+ F T + +P A G
Sbjct: 745 HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
TI + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 96.3 bits (238), Expect = 4e-19
Identities = 75/278 (26%), Positives = 124/278 (44%), Gaps = 25/278 (8%)
Query: 2523 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2582
L+ F +GRI+GL + K LLG+ + D DP +++SL ++
Sbjct: 486 LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 545
Query: 2583 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2642
+ D F AF L Q EL PNG PVT +N EYVR R +
Sbjct: 546 DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 598
Query: 2643 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2702
E A++KG +++P++ L+ ++ L++ G ++++ S T ++
Sbjct: 599 GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 656
Query: 2703 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2751
RWFW VE R L+ F T S +P +GF+ + +I +
Sbjct: 657 ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 711
Query: 2752 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
+ +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 712 IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 96.3 bits (238), Expect = 4e-19
Identities = 75/278 (26%), Positives = 124/278 (44%), Gaps = 25/278 (8%)
Query: 2523 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2582
L+ F +GRI+GL + K LLG+ + D DP +++SL ++
Sbjct: 460 LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 519
Query: 2583 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2642
+ D F AF L Q EL PNG PVT +N EYVR R +
Sbjct: 520 DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 572
Query: 2643 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2702
E A++KG +++P++ L+ ++ L++ G ++++ S T ++
Sbjct: 573 GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 630
Query: 2703 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2751
RWFW VE R L+ F T S +P +GF+ + +I +
Sbjct: 631 ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 685
Query: 2752 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
+ +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 686 IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 95.9 bits (237), Expect = 5e-19
Identities = 82/299 (27%), Positives = 130/299 (43%), Gaps = 27/299 (9%)
Query: 2503 YQPGKRGFYT----PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2558
+Q + YT P N E L+ F +GRI+G+ + K LLG+
Sbjct: 457 FQYSRDDIYTLQINPDSAVNPE-HLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK 515
Query: 2559 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNG 2618
+ D DP ++ SL ++ + D F A+ + Q EL PNG
Sbjct: 516 SITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEII-------QHELKPNG 568
Query: 2619 VKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNG 2678
PV +N EYVR R L E A++KG +V+P++ L+ ++ L++ G
Sbjct: 569 KSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICG 628
Query: 2679 CGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPA 2738
G+++V T + ++ +WFW VE R L+ F T S +P
Sbjct: 629 LGKIDVNDWKVNTRLKHCTPDS-----NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPL 683
Query: 2739 SEEGFQPMPS------ITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
+GF+ + TI D +LP A+TC +R+ +P Y S + L +KLL AI+
Sbjct: 684 --QGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE 740
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 95.5 bits (236), Expect = 6e-19
Identities = 81/280 (28%), Positives = 129/280 (46%), Gaps = 27/280 (9%)
Query: 2526 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 2585
FR GRILGL L+ L R K LL + D + D ++SL+ +
Sbjct: 1307 FRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWM------ 1360
Query: 2586 SDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2642
D D + +DL F ++ EE GQ+ EL P G PVT +N EY+ + + R+
Sbjct: 1361 KDND-IHDILDLTFTVN---EEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIER 1416
Query: 2643 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2702
Q ++ +G +V+ + A + L++ G E+++ + T + +N
Sbjct: 1417 GVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHI 1476
Query: 2703 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIRPPD 2755
+ RWFW+ VE+ + +R L+ F T + S+P EGF P +
Sbjct: 1477 VI----RWFWAAVERFNNEQRLRLLQFVTGTSSIP--YEGFASLRGSNGPRRFCVEKWGK 1530
Query: 2756 DQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2794
LP A+TC +RL +P Y S +L +KLL A+ +T FG
Sbjct: 1531 ITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFG 1570
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 93.2 bits (230), Expect = 3e-18
Identities = 79/285 (27%), Positives = 132/285 (46%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F+ IGR+ G+ + +L R K++L + + HD D
Sbjct: 622 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 681
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVY 2629
Y SLR ++ +D + +DL F ID EE GQ EL G + VT +N
Sbjct: 682 YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 730
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ + A ++G +++P++ ++ + LL+ G G+V+V
Sbjct: 731 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 790
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
T + + N + + +WFW V M +R L+ F T + +P A G
Sbjct: 791 HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 846
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
S T+ + LP A+TC +RL +P Y S + L KL +AI+
Sbjct: 847 PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 891
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 93.2 bits (230), Expect = 3e-18
Identities = 79/285 (27%), Positives = 132/285 (46%), Gaps = 23/285 (8%)
Query: 2513 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2572
P G E L+ F+ IGR+ G+ + +L R K++L + + HD D
Sbjct: 969 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 1028
Query: 2573 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVY 2629
Y SLR ++ +D + +DL F ID EE GQ EL G + VT +N
Sbjct: 1029 YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 1077
Query: 2630 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2689
EY+ + R + ++ + A ++G +++P++ ++ + LL+ G G+V+V
Sbjct: 1078 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1137
Query: 2690 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2745
T + + N + + +WFW V M +R L+ F T + +P A G
Sbjct: 1138 HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1193
Query: 2746 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
S T+ + LP A+TC +RL +P Y S + L KL +AI+
Sbjct: 1194 PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 1238
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 91.3 bits (225), Expect = 1e-17
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 23/284 (8%)
Query: 2520 EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 2579
E L FR GRILGL L+ L R K LL + D + D ++SL
Sbjct: 1335 ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSL--- 1391
Query: 2580 ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDA 2636
Q + + +DL F ++ EE GQV EL G VT +N EY+ +
Sbjct: 1392 ----QWMKDNNITDILDLTFTVN---EEVFGQVTERELKSGGANTQVTEKNKKEYIERMV 1444
Query: 2637 EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE 2696
+ R+ Q A+ +G +V+ + A + L++ G E+++ + T +
Sbjct: 1445 KWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEY--R 1502
Query: 2697 SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIR 2752
G + L+ RWFW+ VE+ + +R L+ F T + S+P A+ G + I
Sbjct: 1503 GGYHDGHLV--IRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1560
Query: 2753 P-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2794
LP A+TC +RL +P Y S +L +KLL A+ +T FG
Sbjct: 1561 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFG 1604
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 90.5 bits (223), Expect = 2e-17
Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 27/283 (9%)
Query: 2523 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2582
L FR IGR + + L + + K +L + V D DP Y SL +
Sbjct: 594 LKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIW-VKE 652
Query: 2583 SQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDAEHR 2639
+ + D +++ F++D +E G++ +L PNG VT +N EY+R AE R
Sbjct: 653 NNIEECD-----LEMYFSVD---KEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWR 704
Query: 2640 MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGE 2699
+ E+ A +G ++LP+ L+ A++ +L+ G E+++ + +
Sbjct: 705 LSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYART 764
Query: 2700 NAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIR 2752
+ + + WFW V+++ +R L+ F T + LP GF P +
Sbjct: 765 SKQIM-----WFWQFVKEIDNEKRMRLLQFVTGTCRLPVG--GFADLMGSNGPQKFCIEK 817
Query: 2753 PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2794
+ LP ++TC +RL +P Y S + LK+KLL AI +T+ FG
Sbjct: 818 VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 860
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 85.1 bits (209), Expect = 9e-16
Identities = 85/298 (28%), Positives = 145/298 (48%), Gaps = 23/298 (7%)
Query: 2502 FYQPGKRGFYTPRPGKNTEARLNCFRN---IGRILGLCLLQNELCPITLNRHVIKVLLGR 2558
F++ G P P + R+ +GR+LG L +N L + + LLG
Sbjct: 791 FFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGT 850
Query: 2559 K--VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELI 2615
V+ H A DP +Y++L L L S D + + L F + + + G QV EL
Sbjct: 851 SADVDIHHLASLDPEVYKNL--LFLKSYEDDVEE----LGLNFTV-VNNDLGEAQVVELK 903
Query: 2616 PNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLL 2675
G PVT N Y+ A++R+ Q A R+GL +V+ L ++ ++L
Sbjct: 904 FGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVL 963
Query: 2676 VNGCG-EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSP 2734
++G ++++ L SFT+++ G +A+ + + FW +VE + E++ L+ F TS
Sbjct: 964 ISGAQVPISLEDLKSFTNYS--GGYSADHPVI--KVFWRVVEGFTDEEKRKLLKFVTSCS 1019
Query: 2735 SLPASEEGFQPM-PSITIRP--PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2789
P GF+ + P+ I D + LPTA+TC++ L +P + + +L+ KLL AI+
Sbjct: 1020 RPPLL--GFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIE 1075
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 83.6 bits (205), Expect = 3e-15
Identities = 73/278 (26%), Positives = 129/278 (46%), Gaps = 15/278 (5%)
Query: 2515 PGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYE 2574
P + L F+ +G ++G+ + + + L V K L + D D + +
Sbjct: 4568 PSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQ 4627
Query: 2575 SLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRK 2634
+L ++ S + F M + + + G V +IP G P+T N EYV +
Sbjct: 4628 TLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVER 4686
Query: 2635 DAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFN 2694
E+R+ + Q + A+R+G+ ++P L LTA+ +V G E++V++L +
Sbjct: 4687 AIEYRLHEMDRQ-VAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR 4745
Query: 2695 DESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS----EEGFQPMPSIT 2750
+ ++ Q +WFW +E+ S ER + F + LPA+ + FQ M
Sbjct: 4746 EVDEQH-----QLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMK--V 4798
Query: 2751 IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2788
RP D LPT+ TC +L +P YSS+ ++ ++L AI
Sbjct: 4799 DRPYDS--LPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 82.0 bits (201), Expect = 7e-15
Identities = 76/286 (26%), Positives = 122/286 (42%), Gaps = 20/286 (6%)
Query: 2508 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 2567
R Y P + FR +G +LG+ + + L V K L G + D +
Sbjct: 4515 RDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSE 4574
Query: 2568 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQN 2627
D + + L+ + F AM L F + G ++L + +T N
Sbjct: 4575 VDK---DFIPGLMYIRDNEATSEEFEAMSLPFTVP---SASGQDIQL--SSKHTHITLDN 4626
Query: 2628 VYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 2687
EYVR +R+ EQ + A+R+G+ V+P L T + +V G ++ + +L
Sbjct: 4627 RAEYVRLAINYRLHEFDEQ-VAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLL 4685
Query: 2688 ISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP 2747
S ++ + E + L+Q WFW ++E S TER + F LP + F+
Sbjct: 4686 KSVATY--KGIEPSASLIQ---WFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD 4740
Query: 2748 SIT-----IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2788
+ PPD LP + TC L +P YS KQ+L++KL AI
Sbjct: 4741 FVIQVLDKYNPPD-HFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
Score = 39.7 bits (91), Expect = 0.042
Identities = 23/107 (21%), Positives = 47/107 (43%), Gaps = 4/107 (3%)
Query: 381 LAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATEKN 440
+A++ G +Y W + + + + PR GL +K++ ++ S+ TE
Sbjct: 4210 VALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDG 4268
Query: 441 KVATWVDETLSSVASKLEHTAQ---TYSELQGERIVSLHCCALYTCA 484
+V TW D + + Q + LQG+++ + C + +T A
Sbjct: 4269 EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315
Score = 37.0 bits (84), Expect = 0.27
Identities = 29/122 (23%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 378 SELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVA- 436
S A++S GELY W E + N + P+ + L + I + + T+A
Sbjct: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLAL 3168
Query: 437 TEKNKVATWVDETLSSV---ASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYW- 492
T++ V +W D + S+ + Q L G+ + + C A ++ A ++ + W
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
Query: 493 WG 494
WG
Sbjct: 3229 WG 3230
Score = 35.0 bits (79), Expect = 1.0
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 7/120 (5%)
Query: 381 LAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATEKN 440
LA+SS+GE+Y W +E + PR L ++V ++A + T
Sbjct: 4052 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPR-VIESLRGIEVVDVAAGGAHSACVTAAG 4110
Query: 441 KVATWVD---ETLSSVASKLEHTAQTYSELQGERIVSLHC---CALYTCAQLENSLYWWG 494
+ TW L S+ + + LQG R+V + C A C +++++ WG
Sbjct: 4111 DLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWG 4170
Score = 32.7 bits (73), Expect = 5.2
Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 8/116 (6%)
Query: 373 CMALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFL-GLTNEKIVLLSANSI 431
C A +S LA++ G + W W + + +R +H + + GL +KIV ++ ++
Sbjct: 3212 CGAQFS--LALTKSGVV--WTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGAL 3267
Query: 432 RATVATEKNKVATWVDE---TLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCA 484
T+ +V W D + + + L+G++I + C + ++ A
Sbjct: 3268 HCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323
>gi|157738609 HECT domain containing 3 [Homo sapiens]
Length = 861
Score = 77.0 bits (188), Expect = 2e-13
Identities = 79/286 (27%), Positives = 125/286 (43%), Gaps = 29/286 (10%)
Query: 2508 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2566
R Y P P A+ + IG+++G L E + L V K L G +V+W DF
Sbjct: 583 RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639
Query: 2567 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQ 2626
D V+ + L ++ + +L F L ++ VELIP G V
Sbjct: 640 AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694
Query: 2627 NVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2686
+ +++ + R+ EQ + AM+ GLL V+P+ L+ LT ++ V G EV V
Sbjct: 695 DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753
Query: 2687 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2746
L T F D E ++ +Q+ FW + + +R + F T LPA
Sbjct: 754 LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800
Query: 2747 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2787
I I P LP ++TC S L++P Y+S ++ ++KL A
Sbjct: 801 -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,312,722
Number of Sequences: 37866
Number of extensions: 5310396
Number of successful extensions: 37557
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 389
Number of HSP's that attempted gapping in prelim test: 29185
Number of HSP's gapped (non-prelim): 5948
length of query: 2796
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2676
effective length of database: 13,703,598
effective search space: 36670828248
effective search space used: 36670828248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.