Search of human proteins with 194018497

Search of human proteins with 194018497

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo
sapiens]
         (1462 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]  2938   0.0  
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   514   e-145
gi|169165432 PREDICTED: similar to FLJ00274 protein [Homo sapiens]    264   5e-70
gi|169165807 PREDICTED: similar to FLJ00274 protein [Homo sapiens]    264   5e-70
gi|169164989 PREDICTED: similar to FLJ00274 protein [Homo sapiens]    264   5e-70
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   236   1e-61
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             222   2e-57
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]   197   5e-50
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   171   6e-42
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   171   6e-42
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   133   1e-30
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   127   8e-29
gi|153791377 apoptosis-inducing protein D [Homo sapiens]               94   1e-18
gi|71274148 pleckstrin homology domain containing, family G (wit...    83   2e-15
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              78   7e-14
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    75   5e-13
gi|13375827 phafin 2 [Homo sapiens]                                    75   5e-13
gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]     75   6e-13
gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens]     75   6e-13
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    72   5e-12
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    70   2e-11
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...    70   2e-11
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    69   4e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    67   1e-10
gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Hom...    66   3e-10
gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Hom...    66   3e-10
gi|6552337 zinc finger, FYVE domain containing 9 isoform 2 [Homo...    66   3e-10
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           65   6e-10
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]            65   6e-10
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...    63   2e-09

>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score = 2938 bits (7616), Expect = 0.0
 Identities = 1462/1462 (100%), Positives = 1462/1462 (100%)

Query: 1    MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESE 60
            MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESE
Sbjct: 1    MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESE 60

Query: 61   TDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDS 120
            TDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDS
Sbjct: 61   TDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDS 120

Query: 121  VAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLED 180
            VAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLED
Sbjct: 121  VAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLED 180

Query: 181  SGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTE 240
            SGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTE
Sbjct: 181  SGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTE 240

Query: 241  DMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHE 300
            DMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHE
Sbjct: 241  DMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHE 300

Query: 301  KKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSE 360
            KKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSE
Sbjct: 301  KKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSE 360

Query: 361  SCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEE 420
            SCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEE
Sbjct: 361  SCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEE 420

Query: 421  ALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTST 480
            ALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTST
Sbjct: 421  ALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTST 480

Query: 481  RVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAK 540
            RVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAK
Sbjct: 481  RVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAK 540

Query: 541  PRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNH 600
            PRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNH
Sbjct: 541  PRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNH 600

Query: 601  LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALT 660
            LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALT
Sbjct: 601  LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALT 660

Query: 661  FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPS 720
            FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPS
Sbjct: 661  FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPS 720

Query: 721  SLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAM 780
            SLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAM
Sbjct: 721  SLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAM 780

Query: 781  NSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDA 840
            NSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDA
Sbjct: 781  NSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDA 840

Query: 841  ESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQEL 900
            ESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQEL
Sbjct: 841  ESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQEL 900

Query: 901  LSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGIL 960
            LSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGIL
Sbjct: 901  LSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGIL 960

Query: 961  EELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVRE 1020
            EELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVRE
Sbjct: 961  EELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVRE 1020

Query: 1021 FEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDR 1080
            FEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDR
Sbjct: 1021 FEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDR 1080

Query: 1081 ANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVL 1140
            ANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVL
Sbjct: 1081 ANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVL 1140

Query: 1141 LYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYG 1200
            LYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYG
Sbjct: 1141 LYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYG 1200

Query: 1201 CLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLR 1260
            CLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLR
Sbjct: 1201 CLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLR 1260

Query: 1261 RHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSF 1320
            RHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSF
Sbjct: 1261 RHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSF 1320

Query: 1321 PLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHW 1380
            PLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHW
Sbjct: 1321 PLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHW 1380

Query: 1381 KKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYS 1440
            KKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYS
Sbjct: 1381 KKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYS 1440

Query: 1441 FKAEDTNSAQRWIEAMEDASVL 1462
            FKAEDTNSAQRWIEAMEDASVL
Sbjct: 1441 FKAEDTNSAQRWIEAMEDASVL 1462


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  514 bits (1324), Expect = e-145
 Identities = 342/894 (38%), Positives = 495/894 (55%), Gaps = 69/894 (7%)

Query: 601  LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIES-DSPDKYKKKKSSFKRFLAL 659
            LP SG       V +    + +    KP  KS  ++ +E    P K   KK+SFK+ L++
Sbjct: 574  LPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSM 633

Query: 660  T----FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRA 715
                 F K    K     +     ++   S  G  + +E D + L    + +S+  K  +
Sbjct: 634  KLSICFMKSDFQKFWSKSSQLGDTTTGHLS-SGEQKGIESDWQGLLVGEEKRSKPIKAYS 692

Query: 716  SESPSSLIFYRDGKRKGVPFSRTVSRVESFEDR--SRPPFLPLPLTKPRSISFPSADT-S 772
            +E+ S     +  K +G   +    R ES +D+  SR      P     S+  P  +   
Sbjct: 693  TENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIR 752

Query: 773  DYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESK 832
             YE IP    +YEN+           A  K  E + +  S+  + D        N +E +
Sbjct: 753  HYEEIP----EYENLPF-------IMAIRKTQELEWQNSSSMEDADA-------NVYEVE 794

Query: 833  QQSADQDAESAYTEPYKVCPISSAAPKE--------DLTSDEEQ--RSSEEEDSASR--- 879
            +     D +      ++    SS A +E        DL SDEE+   SS+E+D +S    
Sbjct: 795  EPYEAPDGQLQLGPRHQHS--SSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSK 852

Query: 880  ---DPSVTHKVEG---QSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEG 933
               DP    + E    +S+   IA+E++SSEK +V++L+ L++DF  AV  A   +   G
Sbjct: 853  GEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQL---G 909

Query: 934  RDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATH 993
            +  +    L Q L  LP +++L++ +L+ELEER+ +W  QQ++AD+F+ +      ++T+
Sbjct: 910  KPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969

Query: 994  ILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDY 1053
            I +FD+ + LL E C  +P  AA VREFE S +  +   KH LL+ VQR+ QY++LLTDY
Sbjct: 970  IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029

Query: 1054 LNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGRE 1113
            L NL  D+ +Y +TQ AL+++ +V + AND+M+QG+N QKL+ I++S+ G  +++QPGR 
Sbjct: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089

Query: 1114 FLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVP 1173
            FLKEG LMK++ K  +PR  FL ND LLYT P + G Y+L N L++A MKV +P  E   
Sbjct: 1090 FLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQ 1149

Query: 1174 YALKIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSV-----EIRERL 1228
              LKIE+ E   +LSASS  ERDEW   +SRA+ E  K +       S+     E +E +
Sbjct: 1150 NELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEV 1209

Query: 1229 GVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDR 1288
               LG + P  +P T   MCM C  +F+LT RRHHC ACGKIVC+ CS NKY L YLK++
Sbjct: 1210 S-PLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQ 1268

Query: 1289 MAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQK 1348
             A+VC+ CF EL+K       L  +    +  P  + +   SA SSV  SI PS  +KQK
Sbjct: 1269 PARVCEHCFQELQK-------LDHQHSPRIGSP-GNHKSPSSALSSVLHSI-PSG-RKQK 1318

Query: 1349 KVPSALTEVAASGEGSAISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMP 1408
            K+P+AL EV+A+ E S++SGYL R K  K+ WK  WFVIK KVLYTY ASED  ALES P
Sbjct: 1319 KIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQP 1378

Query: 1409 LLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDASVL 1462
            LLGFT+   K+E S     +F L HK  LFY FKAED +SAQ+WIEA ++ ++L
Sbjct: 1379 LLGFTVIQVKDENSE--SKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL 1430


>gi|169165432 PREDICTED: similar to FLJ00274 protein [Homo sapiens]
          Length = 176

 Score =  264 bits (674), Expect = 5e-70
 Identities = 133/172 (77%), Positives = 146/172 (84%), Gaps = 5/172 (2%)

Query: 272 PEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFE 331
           PEVLEEGCEEATGV GGEQVDL E PDHE+K+NQ+VAAATLED  QDE AEESCQIV F+
Sbjct: 4   PEVLEEGCEEATGVIGGEQVDLGELPDHEEKSNQKVAAATLEDRTQDEPAEESCQIVLFQ 63

Query: 332 NDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVG 391
           N+CM++FVTSLTGSPYEFFPT+STSFC ESCSP SES K LESEQAPKLGL AEE+P+VG
Sbjct: 64  NNCMDNFVTSLTGSPYEFFPTKSTSFCRESCSPFSESVKSLESEQAPKLGLCAEEDPVVG 123

Query: 392 ALCGQCGSLQGGAAEGPAAPDVVVVLEEE-----ALDDALANPYVMGVGLPG 438
           ALCGQ G LQ G AEGP APDVVV+ +EE      +DD LANPYVMGVGL G
Sbjct: 124 ALCGQHGPLQDGVAEGPTAPDVVVLPKEEEKEEVIVDDMLANPYVMGVGLLG 175


>gi|169165807 PREDICTED: similar to FLJ00274 protein [Homo sapiens]
          Length = 176

 Score =  264 bits (674), Expect = 5e-70
 Identities = 133/172 (77%), Positives = 146/172 (84%), Gaps = 5/172 (2%)

Query: 272 PEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFE 331
           PEVLEEGCEEATGV GGEQVDL E PDHE+K+NQ+VAAATLED  QDE AEESCQIV F+
Sbjct: 4   PEVLEEGCEEATGVIGGEQVDLGELPDHEEKSNQKVAAATLEDRTQDEPAEESCQIVLFQ 63

Query: 332 NDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVG 391
           N+CM++FVTSLTGSPYEFFPT+STSFC ESCSP SES K LESEQAPKLGL AEE+P+VG
Sbjct: 64  NNCMDNFVTSLTGSPYEFFPTKSTSFCRESCSPFSESVKSLESEQAPKLGLCAEEDPVVG 123

Query: 392 ALCGQCGSLQGGAAEGPAAPDVVVVLEEE-----ALDDALANPYVMGVGLPG 438
           ALCGQ G LQ G AEGP APDVVV+ +EE      +DD LANPYVMGVGL G
Sbjct: 124 ALCGQHGPLQDGVAEGPTAPDVVVLPKEEEKEEVIVDDMLANPYVMGVGLLG 175


>gi|169164989 PREDICTED: similar to FLJ00274 protein [Homo sapiens]
          Length = 176

 Score =  264 bits (674), Expect = 5e-70
 Identities = 133/172 (77%), Positives = 146/172 (84%), Gaps = 5/172 (2%)

Query: 272 PEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFE 331
           PEVLEEGCEEATGV GGEQVDL E PDHE+K+NQ+VAAATLED  QDE AEESCQIV F+
Sbjct: 4   PEVLEEGCEEATGVIGGEQVDLGELPDHEEKSNQKVAAATLEDRTQDEPAEESCQIVLFQ 63

Query: 332 NDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVG 391
           N+CM++FVTSLTGSPYEFFPT+STSFC ESCSP SES K LESEQAPKLGL AEE+P+VG
Sbjct: 64  NNCMDNFVTSLTGSPYEFFPTKSTSFCRESCSPFSESVKSLESEQAPKLGLCAEEDPVVG 123

Query: 392 ALCGQCGSLQGGAAEGPAAPDVVVVLEEE-----ALDDALANPYVMGVGLPG 438
           ALCGQ G LQ G AEGP APDVVV+ +EE      +DD LANPYVMGVGL G
Sbjct: 124 ALCGQHGPLQDGVAEGPTAPDVVVLPKEEEKEEVIVDDMLANPYVMGVGLLG 175


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score =  236 bits (602), Expect = 1e-61
 Identities = 169/636 (26%), Positives = 298/636 (46%), Gaps = 71/636 (11%)

Query: 842  SAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASR------DPSVTHKVEGQSRALV 895
            +A    Y+   I    P E+  ++ E +  E E+  S       D     K   + +   
Sbjct: 150  NASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHK 209

Query: 896  IAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDL 955
            IA ELL +E+AYV  L  L+  F+  ++      +   R +   E + +  S + +I+  
Sbjct: 210  IANELLLTERAYVNRLDLLDQVFYCKLL------EEANRGSFPAEMVNKIFSNISSINAF 263

Query: 956  HQG-ILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRL 1014
            H   +L ELE+R+  WE+  ++ D+          +  ++  FD  + L+       P+ 
Sbjct: 264  HSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQF 323

Query: 1015 AAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLI 1074
             + V E ++    GS T +H +L  VQR+ +Y++LL DYL  L PDS ++++ + +L +I
Sbjct: 324  KSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEII 383

Query: 1075 SKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKN--RRPRH 1132
            S     +N ++ + ENL+KL+ I   +  + D++ P  E +KEG ++K+  +N   + R+
Sbjct: 384  STAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERY 443

Query: 1133 LFLMNDVLLYTYPQ---KDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSA 1189
            LFL N++LLY  P+      K+ ++  + +  MK+     E+ P+  ++   E  L L A
Sbjct: 444  LFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQA 503

Query: 1190 SSCAERDEWYGCLSRALPEDYKAQALAAFHHSV----EIRERLGVS-LGERPPTLVPVTH 1244
            SS  +++EW   L   +  D   Q    F +++    +I   +  + LG+R P  +    
Sbjct: 504  SSAQDKEEWIKALQETI--DAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNE 561

Query: 1245 VMMCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKR 1303
            V MCM C   F +LT RRHHC ACG +VC  CS  K  L+Y   +++KVC  C       
Sbjct: 562  VTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDC------- 614

Query: 1304 GRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEG 1363
                                            +Q I+  T  ++KK    L   +A   G
Sbjct: 615  --------------------------------YQIISGFTDSEEKKRKGILEIESAEVSG 642

Query: 1364 SAISGYLSRCKRGKRHWKKLWFVIKGK---VLYTYMASEDKVALESMPLLGFTIAPEKEE 1420
            +++     +     + W+K W VI  +   VLY Y A +D  A  ++PLLG+ +  ++  
Sbjct: 643  NSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVV--DEMP 700

Query: 1421 GSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAM 1456
             S+++   F L   K++ +SF A+     Q+W++ +
Sbjct: 701  RSADLPHSFKLTQSKSV-HSFAADSEELKQKWLKVI 735



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 51/203 (25%), Positives = 73/203 (35%), Gaps = 34/203 (16%)

Query: 80  DEGSVGNKALVSPESSAEEEE--EREEGGEACGLEGTGAGEDSV---APAAPGAGALSRE 134
           +E    + + VS E  ++  +   R EGG +         E +V   AP  PG   L+  
Sbjct: 2   EEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTT 61

Query: 135 GEE-----------GTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLEDSGP 183
            ++           G D       + C        Q     EEEK      + S++ S P
Sbjct: 62  PQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEP 121

Query: 184 WAGEGVFQSDLLLPHI-HGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDM 242
                     LL  HI +GE  E    P     D  +G AS D +    G GP  P E+ 
Sbjct: 122 ----------LLDTHIVNGERDETATAPASPTTDSCDGNAS-DSSYRTPGIGPVLPLEER 170

Query: 243 GQDAE------DTSEEPPEKEEL 259
           G + E      +  E P E E+L
Sbjct: 171 GAETETKVQERENGESPLELEQL 193


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  222 bits (565), Expect = 2e-57
 Identities = 169/633 (26%), Positives = 292/633 (46%), Gaps = 65/633 (10%)

Query: 852  PISSAAP----KEDLTSD-EEQRSSEEEDSASRDPSV-------THKVEGQSRALVIAQE 899
            P++ A P     +++ SD EE+   EEE+   R+  V       + ++  Q +   IA E
Sbjct: 321  PVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANE 380

Query: 900  LLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQG- 958
            LL +EKAYV  L  L+  F   ++      +   R +   + +    S + +I+  HQ  
Sbjct: 381  LLQTEKAYVSRLHLLDQVFCARLLE-----EARNRSSFPADVVHGIFSNICSIYCFHQQF 435

Query: 959  ILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAV 1018
            +L ELE+R+  W+   ++ D+          +  ++  FDR + L++     S +    +
Sbjct: 436  LLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVII 495

Query: 1019 REFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVT 1078
             E ++    G+ T +H +L  VQR+ +Y++LL DYL  L   S +  + Q +L LI+   
Sbjct: 496  HEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAA 555

Query: 1079 DRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKN--RRPRHLFLM 1136
            + +N ++ + E + KL+ +   + G+ D++ P +E +KEG ++K++ KN   + R+L L 
Sbjct: 556  EHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILF 615

Query: 1137 NDVLLYTYPQ---KDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCA 1193
            ND LLY  P+      K+ ++  + V  M++       +P    +   +  L L A +  
Sbjct: 616  NDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEE 675

Query: 1194 ERDEWYGCLSRALPEDYKAQALAAFHHSVEIRER------LGVSLGERPPTLVPVTHVMM 1247
            E+ +W   ++  L +  +        +S    +         V LG+R PT +    V M
Sbjct: 676  EKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTM 735

Query: 1248 CMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRA 1306
            CM C   F S+T RRHHC ACG +VC  CS  +  L Y  +R  +VC  C+  L      
Sbjct: 736  CMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL----HG 791

Query: 1307 VPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAI 1366
            VPG             SSP            + +  T ++++ +      VAA  E S I
Sbjct: 792  VPG-------------SSP------------ACSQHTPQRRRSILEKQASVAA--ENSVI 824

Query: 1367 SGYLSRCKRGKRHWKKLWFVI---KGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSS 1423
              +L   ++G + W K WFV+   +  VLY Y A +D  A  S+PL+GF + P +     
Sbjct: 825  CSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERP 884

Query: 1424 EVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAM 1456
            +   +F +      +Y F  E     +RW+  +
Sbjct: 885  DRRHVFKITQSHLSWY-FSPETEELQRRWMAVL 916


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score =  197 bits (502), Expect = 5e-50
 Identities = 166/583 (28%), Positives = 259/583 (44%), Gaps = 66/583 (11%)

Query: 896  IAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDL 955
            I QELL +E+AYV  L  L+  F   +++               + +R   S + +I+  
Sbjct: 106  IVQELLETEQAYVARLHLLDQVFFQELLKTA-----RSSKAFPEDVVRVIFSNISSIYQF 160

Query: 956  H-QGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRL 1014
            H Q  L EL+ RL +W +  ++ DV          ++ ++  F+R   LL+     SP  
Sbjct: 161  HSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLF 220

Query: 1015 AAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLI 1074
               +   + S   GS T +H +L  VQR+ +Y++LL +Y+  L   + +  + Q AL +I
Sbjct: 221  QEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMI 280

Query: 1075 SKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRP--RH 1132
                  +N ++ + E LQ L  +   +  + D++ P    L+EG ++K++ +   P  R+
Sbjct: 281  FSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340

Query: 1133 LFLMNDVLLYTYP---QKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSA 1189
            LFL N++LLY  P   Q   +++++  + VA MKV   +  + P++  +   +  L L A
Sbjct: 341  LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQA 400

Query: 1190 SSCAERDEWYGCLSRALP------EDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVT 1243
             S  E   W      A+       E +KA A       ++ +E     LG R P  V   
Sbjct: 401  RSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGP-EGDIQEQELQSEELGLRAPQWVRDK 459

Query: 1244 HVMMCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKK 1302
             V MCM C   F +LT RRHHC ACG +VC  CS  +  LKY  +R  +VC  C+  L  
Sbjct: 460  MVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFL-- 517

Query: 1303 RGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGE 1362
             G  +P    ++   +    SS     S   S  Q I                     G+
Sbjct: 518  TGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLI---------------------GD 556

Query: 1363 GSAISGYLSRCKRGKRHWKKLWFVIKGK---VLYTYMASEDKVALESMPLLGF--TIAPE 1417
                SG      RG       W VI      VLY Y A +D  A  S+PLLG+  T+ P+
Sbjct: 557  KWGKSG-----PRG-------WCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQ 604

Query: 1418 KEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
             +        +F L     L Y+FKAE      RW++AME A+
Sbjct: 605  GDP------RVFQLQQSGQL-YTFKAETEELKGRWVKAMERAA 640


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  171 bits (432), Expect = 6e-42
 Identities = 163/700 (23%), Positives = 281/700 (40%), Gaps = 110/700 (15%)

Query: 808  SRALSTANENDGYVDMSS------FNAFESKQQSADQDAESAYTEPYKVCPISSAAPKED 861
            S +L   N + G    SS      F   E  +         A+ E      +    P+E+
Sbjct: 66   SGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKVTPQEE 125

Query: 862  LTSD--EEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFH 919
              SD  EE  S      A +D  +     G  + L IAQELL +E+ YV+ L  L+  F 
Sbjct: 126  ADSDVGEEPDSENTPQKADKDAGLAQH-SGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184

Query: 920  GAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLH-QGILEELEERLSN-WESQQKVA 977
              +  A           +  E +    S + +IH  H Q +L EL+ R++  W++  ++ 
Sbjct: 185  TRLTDA----------GIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLG 234

Query: 978  DVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLL 1037
            D+          +  ++  FDR +GL+S     SP     V   ++    G+ T +H +L
Sbjct: 235  DILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHML 294

Query: 1038 RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHI 1097
              VQR+ +Y++LL DYL  L  D+ +  + + +L LIS   + +N ++ + E + KL+ +
Sbjct: 295  EPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEV 354

Query: 1098 EHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRP--RHLFLMNDVLLYTYPQ---KDGKYR 1152
               + G+ D++ P  E +KEG + K++ KN  P  RHLFL N ++LY  P+      K+ 
Sbjct: 355  YEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFS 414

Query: 1153 LKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRALPE-DYK 1211
            ++  + ++ ++V   V     +   I   +  L L   +  E+ EW   +   + +    
Sbjct: 415  VREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQN 474

Query: 1212 AQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVM------------------------- 1246
            ++   AF  +    E   +S      +  PV  V+                         
Sbjct: 475  SETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKE 534

Query: 1247 --MCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKR 1303
               C +CG  F S+T RRHHC  CG ++C  CS      K    R ++VC  CF      
Sbjct: 535  KQSCKSCGETFNSITKRRHHCKLCGAVICGKCSE----FKAENSRQSRVCRDCF------ 584

Query: 1304 GRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEG 1363
                                           + Q + P + +K            A  + 
Sbjct: 585  -------------------------------LTQPVAPESTEKTP---------TADPQP 604

Query: 1364 SAISGYLSRCKRGKRHWKKLWFVI---KGKVLYTYMASEDKVALESMPLLGFTIAPEKEE 1420
            S + G L   + G+  W ++W  I     +VL+    S+D     ++PL    ++    E
Sbjct: 605  SLLCGPLRLSESGET-WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPE 663

Query: 1421 GSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
               + G ++ L   K  +Y   A      Q+W+E +  A+
Sbjct: 664  ERLDSGHVWKLQWAKQSWY-LSASSAELQQQWLETLSTAA 702


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  171 bits (432), Expect = 6e-42
 Identities = 163/700 (23%), Positives = 281/700 (40%), Gaps = 110/700 (15%)

Query: 808  SRALSTANENDGYVDMSS------FNAFESKQQSADQDAESAYTEPYKVCPISSAAPKED 861
            S +L   N + G    SS      F   E  +         A+ E      +    P+E+
Sbjct: 66   SGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKVTPQEE 125

Query: 862  LTSD--EEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFH 919
              SD  EE  S      A +D  +     G  + L IAQELL +E+ YV+ L  L+  F 
Sbjct: 126  ADSDVGEEPDSENTPQKADKDAGLAQH-SGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184

Query: 920  GAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLH-QGILEELEERLSN-WESQQKVA 977
              +  A           +  E +    S + +IH  H Q +L EL+ R++  W++  ++ 
Sbjct: 185  TRLTDA----------GIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLG 234

Query: 978  DVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLL 1037
            D+          +  ++  FDR +GL+S     SP     V   ++    G+ T +H +L
Sbjct: 235  DILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHML 294

Query: 1038 RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHI 1097
              VQR+ +Y++LL DYL  L  D+ +  + + +L LIS   + +N ++ + E + KL+ +
Sbjct: 295  EPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEV 354

Query: 1098 EHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRP--RHLFLMNDVLLYTYPQ---KDGKYR 1152
               + G+ D++ P  E +KEG + K++ KN  P  RHLFL N ++LY  P+      K+ 
Sbjct: 355  YEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFS 414

Query: 1153 LKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRALPE-DYK 1211
            ++  + ++ ++V   V     +   I   +  L L   +  E+ EW   +   + +    
Sbjct: 415  VREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQN 474

Query: 1212 AQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVM------------------------- 1246
            ++   AF  +    E   +S      +  PV  V+                         
Sbjct: 475  SETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKE 534

Query: 1247 --MCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKR 1303
               C +CG  F S+T RRHHC  CG ++C  CS      K    R ++VC  CF      
Sbjct: 535  KQSCKSCGETFNSITKRRHHCKLCGAVICGKCSE----FKAENSRQSRVCRDCF------ 584

Query: 1304 GRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEG 1363
                                           + Q + P + +K            A  + 
Sbjct: 585  -------------------------------LTQPVAPESTEKTP---------TADPQP 604

Query: 1364 SAISGYLSRCKRGKRHWKKLWFVI---KGKVLYTYMASEDKVALESMPLLGFTIAPEKEE 1420
            S + G L   + G+  W ++W  I     +VL+    S+D     ++PL    ++    E
Sbjct: 605  SLLCGPLRLSESGET-WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPE 663

Query: 1421 GSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
               + G ++ L   K  +Y   A      Q+W+E +  A+
Sbjct: 664  ERLDSGHVWKLQWAKQSWY-LSASSAELQQQWLETLSTAA 702


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
            sapiens]
          Length = 1054

 Score =  133 bits (334), Expect = 1e-30
 Identities = 93/334 (27%), Positives = 164/334 (49%), Gaps = 22/334 (6%)

Query: 885  HKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQ 944
            HK      A  I +E+L++E+ Y++ L+ + + F  AV++          D +    +  
Sbjct: 528  HKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVK---------EDAMPATLMTL 578

Query: 945  GLSELPAIHDLHQGILEELEERLSNWE---------SQQKVADVFLAREQGFDHHATHIL 995
              S +  I++ H+G L E+E+RL+ WE         S Q++ D+ L   +      ++  
Sbjct: 579  LFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQ 638

Query: 996  QFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLN 1055
            + D  L  L +      +L A  +EFE   +         LL+ +QRL  Y++LL     
Sbjct: 639  RHDEVLTELEKATKRCKKLEAVYKEFELQ-KVCYLPLNTFLLKPIQRLLHYRLLLRRLCG 697

Query: 1056 NLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFL 1115
            +  P   +Y +   AL  I++VT      + + ENLQKL  ++  + G  +L+ PGREF+
Sbjct: 698  HYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFI 757

Query: 1116 KEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDG--KYRLKNTLAVANMKVSRPVME-KV 1172
            +EG L K+T K  + R  FL +D+LLYT     G   +R++  L +  M V     E  V
Sbjct: 758  REGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSV 817

Query: 1173 PYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206
            P+   I  ++  ++++AS+  E+++W   L+ A+
Sbjct: 818  PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAI 851



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 1/95 (1%)

Query: 1366 ISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEV 1425
            +SGYL R  +    W+KLW V     L+ Y   +D   L S+PLLG++++  +E      
Sbjct: 932  LSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHK 991

Query: 1426 GPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
              +F L  K  +++ F+AE   + +RW+E ++ AS
Sbjct: 992  DYVFKLQFKSHVYF-FRAESKYTFERWMEVIQGAS 1025


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score =  127 bits (319), Expect = 8e-29
 Identities = 148/611 (24%), Positives = 250/611 (40%), Gaps = 71/611 (11%)

Query: 647  KKKKSSFKRFLALTFKKKTENKLHVDVN--VSSSRSSSES------SYHGPSRILEVDRR 698
            K +K SFKR   L   +   N  + D    + +SR   +S       +H   R+ E  + 
Sbjct: 265  KVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKP 324

Query: 699  SLSNSPQLKSRTGKLRASESPSSLI--FYRDGKRKGVPFSRTVSRVESFEDRSRPPF--- 753
                 P L SR    R S      +  + ++G  K V F R  S++ S    +  P    
Sbjct: 325  K--PKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELN 382

Query: 754  --------LPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFE 805
                        LT       P   +      P +++  E    P   P R+ A  K   
Sbjct: 383  SEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG-EPGSHPSPAPRRSPAGNKQ-A 440

Query: 806  DQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKE----- 860
            D + +  T  E +   D +  +  +  Q S      S +     V      AP       
Sbjct: 441  DGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSP 500

Query: 861  DLTSDEEQRS--------------SEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKA 906
            +L+ D +Q S              +++ED   R    T K      A  IA+E+ ++E+ 
Sbjct: 501  NLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK------AYFIAKEVSTTERT 554

Query: 907  YVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEER 966
            Y++ L+ +   F   V +  +D   E   +L              +H  H   L+E+E+R
Sbjct: 555  YLKDLEVITSWFQSTVSK--EDAMPEALKSLI-------FPNFEPLHKFHTNFLKEIEQR 605

Query: 967  LSNWESQ--------QKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAV 1018
            L+ WE +        Q++ DV L   QG  H A H+ +    L  L      S RL    
Sbjct: 606  LALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFC 665

Query: 1019 REFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVT 1078
            R+FE   +         LLR + RL  Y+ +L     +  P  A++ + + AL+ I+++ 
Sbjct: 666  RDFELQ-KVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMV 724

Query: 1079 DRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMND 1138
             + + +M + EN QKL  ++  + G  +L+ PGREF++ G+L K++GK  + R  FL ND
Sbjct: 725  AQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFND 784

Query: 1139 VLLYTYP--QKDGKYRLKNTLAVANMKVSRPVME-KVPYALKIETSESCLMLSASSCAER 1195
            VLLYT        ++++   L +  M +     E  VP+ L +      ++++ASS +E 
Sbjct: 785  VLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEM 844

Query: 1196 DEWYGCLSRAL 1206
            ++W   +  A+
Sbjct: 845  EKWVEDIQMAI 855



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 30/95 (31%), Positives = 52/95 (54%), Gaps = 1/95 (1%)

Query: 1366 ISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEV 1425
            +SG L R  +    W+KLW V     L+ Y + +D   L S+PLLG+++    E  + + 
Sbjct: 935  LSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQK 994

Query: 1426 GPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
              +F L+ K  ++Y F+AE   + +RW+E +  A+
Sbjct: 995  DYVFKLHFKSHVYY-FRAESEYTFERWMEVIRSAT 1028


>gi|153791377 apoptosis-inducing protein D [Homo sapiens]
          Length = 279

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 67/231 (29%), Positives = 101/231 (43%), Gaps = 40/231 (17%)

Query: 1090 NLQKLVHIEHSVRGQGD-LLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLY-TYPQK 1147
            N Q++  +E      G  L  PGR  L EG L K   K  +PR  FL ND+L+Y +    
Sbjct: 11   NSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLN 70

Query: 1148 DGKYRLKNTLAVANMKVSRPVMEKVPYALK------IETSESCLMLSASSCAERDEWYGC 1201
              KYR ++ + +  +      +E +P  L+      I+T++   ++SA+S  ER EW   
Sbjct: 71   KRKYRSQHIIPLEEV-----TLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISH 125

Query: 1202 LSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTL------VPVTHVMMCMNCG-CD 1254
            +   +    +A                      RPP+       +P     +CM C    
Sbjct: 126  IEECVRRQLRATG--------------------RPPSTEHAAPWIPDKATDICMRCTQTR 165

Query: 1255 FSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGR 1305
            FS   RRHHC  CG +VC  CSR ++ L  L  +  +VC  C+ EL  + R
Sbjct: 166  FSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQR 216


>gi|71274148 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 96/435 (22%), Positives = 185/435 (42%), Gaps = 44/435 (10%)

Query: 806  DQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPIS-SAAPKEDLTS 864
            D  R +S  + +       S  +F S+           + +  +V  I     P    +S
Sbjct: 5    DSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSS 64

Query: 865  DEEQRSS------EEEDSASRDPSVTHKVEGQSRALVIA---------------QELLSS 903
             E QR +        ++ + R P    +V+       IA               QE+L +
Sbjct: 65   SELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILET 124

Query: 904  EKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEEL 963
            E+ YV+ L+ +  D+       LD +  + +  L  EE       +  I+  +  +L++L
Sbjct: 125  ERTYVQDLKSIVEDY-------LDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDL 177

Query: 964  EERLSNWESQQ-KVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFE 1022
            E    N E+    +A+ F+++ + F  +  +   + R + +L+E C+ +  LA   RE +
Sbjct: 178  E----NCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTE-CMRNKILAKFFRERQ 232

Query: 1023 QSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRAN 1082
            ++++       + LL+ VQR+ +Y +LL +  N+L  D+  YD    A+  + +V    N
Sbjct: 233  ETLKHSLPLGSY-LLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291

Query: 1083 DSMEQGENLQKLVHIEHSVRG-QGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLL 1141
            D   + E+  +L  I+  +   +G  L    E + EGT      KN R   LFL + +LL
Sbjct: 292  DMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERT--LFLFDKLLL 349

Query: 1142 YTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKI---ETSESCLMLSASSCAERDEW 1198
             T  ++D  +  K  +   N+ +   V+ K P +  +   +  +    + A S  ++  W
Sbjct: 350  IT-KKRDDTFTYKAHILCGNLMLVE-VIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLW 407

Query: 1199 YGCLSRALPEDYKAQ 1213
               L R + E++ A+
Sbjct: 408  VLHLKRLILENHAAK 422


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 141/595 (23%), Positives = 226/595 (37%), Gaps = 64/595 (10%)

Query: 43   DRGLDEGPRSI--PKCS-ESETDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEE 99
            D G  +G   I  P+   E++ + + +  P       E + E    ++ + +PE+  E +
Sbjct: 1825 DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQ 1884

Query: 100  EEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDL----ALEDEGEGCADEPG 155
             E E+         T   E  V P + GA A   E E   +     ALE EGE   +  G
Sbjct: 1885 PESED-------VETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEG 1937

Query: 156  TLEQVSR--SEEEEKLVQPHREC----SLEDSGPWAGEGV--FQSDLLLPHIHGE----- 202
               Q +   ++E E   QP  E       E+      E V   + ++      GE     
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997

Query: 203  -DQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAG 261
             D E P+  GE +E +EE    +D   A   S  +   E  G+  +   +  PE + +  
Sbjct: 1998 EDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEA 2057

Query: 262  VQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQD--- 318
             +  E A +    ++E   E       E VD  E     +  ++ V A   E  AQ    
Sbjct: 2058 PEAEEEAQEAEGEVQEA--EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG 2115

Query: 319  -ESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQA 377
             E+ E   +  P E++ +E         P E    E+     E+  P SE  +  E+E+ 
Sbjct: 2116 IEAPETEGEAQP-ESEGIEAPEAEGEAQP-ESEGVEAQDAEGEA-QPESEGIEAQEAEEE 2172

Query: 378  PKLGLRAEENPMV-GALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGL 436
             +  L   E P   G    +   ++   AEG A P++  V   EA ++A   P   GV  
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP--EGVET 2230

Query: 437  P---GQAAPGEGGQAASDALG------GYGSKEELNCEAEGGLVPADRKNTSTRVRPHSG 487
            P   G+A P   G+   +  G      G G  EE         VP DR        P  G
Sbjct: 2231 PEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEE--ASESSSPVPEDRPTPP----PSPG 2284

Query: 488  KVAGYVPETVP-EETGPEAG-SSAPGIGGAAEEVGKTLLSLEGKPLEASRALP-AKPRAF 544
               G  P   P  +TGP +  +S+ G     +     +L     P   S   P A+ +A 
Sbjct: 2285 ---GDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKAT 2341

Query: 545  TLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKE--DNLSLSCVIGSSGSFSQ 597
             +YP S + E  E P+   + PE    + + ++  +   +L+ +  +G +  F Q
Sbjct: 2342 RMYPESSTSEQEEAPLG-SRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQ 2395



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 105/472 (22%), Positives = 162/472 (34%), Gaps = 64/472 (13%)

Query: 112  EGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQ 171
            E T      VAP        S    +G +  L   G G +  PG    V   E+ E   +
Sbjct: 1699 EHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGL---GPGLSQGPG----VDEGEDGEGSQR 1751

Query: 172  PHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADE 231
             +R     D  P  GE   + D +     G+      + G    + E+        G   
Sbjct: 1752 LNR-----DKDPKLGEA--EGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETG 1804

Query: 232  GSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGE-Q 290
            G G        G+ A    ++P + +   G+       + PE   E   E+ GV   E +
Sbjct: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-------EAPEAEGEAQPESEGVEAPEAE 1857

Query: 291  VDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFF 350
             D  E     +  +++V A   E  AQ ES               ED  T    + +E  
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPES---------------EDVET--PEAEWEVQ 1900

Query: 351  PTESTSFCSES---CSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEG 407
            P    +   E+     P +ES + LE+E         E+ P       Q        AEG
Sbjct: 1901 PESEGAEAPEAEKEAQPETESVEALETE--------GEDEPESEGAEAQEAEEAAQEAEG 1952

Query: 408  PAAPDVVVVLEEEALDDA---LANPYVMGVGLPGQAAPGEGGQAASD--ALGGYGSKEEL 462
               P+  V+  +EA ++A     +   + V +  Q A GE    + D  A    G  +E 
Sbjct: 1953 QTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEA 2012

Query: 463  NCEA--EGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVG 520
              EA  E   V A  K+     +   G+      +  PE  G E    AP     A+E  
Sbjct: 2013 EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVE----APEAEEEAQEAE 2068

Query: 521  KTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLD 572
              +   EG+    S  + A+       P S   EG E P +  +  +  G++
Sbjct: 2069 GEVQEAEGEAHPESEDVDAQEAEGEAQPES---EGVEAPEAEGEAQKAEGIE 2117



 Score = 39.7 bits (91), Expect = 0.022
 Identities = 51/189 (26%), Positives = 75/189 (39%), Gaps = 50/189 (26%)

Query: 134  EGEEGTDLALEDEGEGCADEPGTLEQVSRSEE-EEKLVQPHRECSLEDSGPWAGEGVFQS 192
            E +EGT      EGEG  +E   LE+    E  +E+ VQ      LE++    GEG  + 
Sbjct: 1305 ETKEGT------EGEGLQEEAVQLEETKTEEGLQEEGVQ------LEETKETEGEGQQEE 1352

Query: 193  DLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMG--------- 243
            +  L  I     E     G   E+ +EG     P G  +G   +   ++ G         
Sbjct: 1353 EAQLEEIEETGGEGLQEEGVQLEEVKEG-----PEGGLQGEALEEGLKEEGLPEEGSVHG 1407

Query: 244  --------QDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSE 295
                     D + + E+ P +EE AG + + +A  CP    EG EE T           E
Sbjct: 1408 QELSEASSPDGKGSQEDDPVQEEEAG-RASASAEPCP---AEGTEEPT-----------E 1452

Query: 296  PPDHEKKTN 304
            PP H  +T+
Sbjct: 1453 PPSHLSETD 1461



 Score = 35.0 bits (79), Expect = 0.53
 Identities = 46/213 (21%), Positives = 80/213 (37%), Gaps = 30/213 (14%)

Query: 203  DQEPPDTPGEAEEDDE---------EGCA-STDPAGADEGSGPDRPTEDMGQDAEDTSEE 252
            D    ++PG+ E   +           CA +T+   A+  S   R + ++ Q AE+T +E
Sbjct: 1240 DSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQE 1299

Query: 253  PPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATL 312
              + EE     E E   +    LEE   E      G Q++ ++  + E +  +E     +
Sbjct: 1300 EVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEI 1359

Query: 313  EDHAQDESAEESCQIVP--------FENDCMEDFVTSLTGSPYEFFPTESTSFCSESCSP 364
            E+   +   EE  Q+           + + +E+      G   E  P E +    E    
Sbjct: 1360 EETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE------GLKEEGLPEEGSVHGQELSEA 1413

Query: 365  LSESAKG------LESEQAPKLGLRAEENPMVG 391
             S   KG      ++ E+A +    AE  P  G
Sbjct: 1414 SSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446



 Score = 34.3 bits (77), Expect = 0.90
 Identities = 40/184 (21%), Positives = 61/184 (33%), Gaps = 21/184 (11%)

Query: 93   ESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCAD 152
            E  A+ EE  E GGE    EG    E    P     G    EG +   L  E    G   
Sbjct: 1351 EEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQEL 1410

Query: 153  EPGTLEQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGE 212
               +      S+E++ + +     +   + P   EG               +EP + P  
Sbjct: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGT--------------EEPTEPPSH 1456

Query: 213  AEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCP 272
              E D    AS   +G+    G ++P        E T  +P +     G  E  ++  C 
Sbjct: 1457 LSETDPS--ASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQ-----GAAERSSSVACS 1509

Query: 273  EVLE 276
              L+
Sbjct: 1510 AALD 1513


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 88/372 (23%), Positives = 160/372 (43%), Gaps = 30/372 (8%)

Query: 851  CPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEM 910
            C   +A P  +    E  R ++E   AS+  S   K +   R  V A  LL +E++YVE 
Sbjct: 1029 CLPLAAPPSAEAKPPEAARPADEPTPASKCCS---KPQVDMRKHV-AMTLLDTEQSYVES 1084

Query: 911  LQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGL-SELPAIHDLHQGILEELEERLSN 969
            L+ L   +       +  +       L    L   +  ++P + + H+  LE++   +  
Sbjct: 1085 LRTLMQGY-------MQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQT 1137

Query: 970  WESQQKVADVFLAREQGFDHHA---THILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQ 1026
            W +QQKV  + +   Q F        +    D +L       +      A ++  EQS++
Sbjct: 1138 WHAQQKVGALLV---QSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMR 1194

Query: 1027 GG--SQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDS 1084
                 Q     +++ VQR+ +Y++L+ D L +   D  ++     A   I +V +R N  
Sbjct: 1195 ENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKG 1254

Query: 1085 MEQGENLQK----LVHIEHSVRGQGDLLQPGREFLKEGTLMKVTG-KNRRPRHLFLMNDV 1139
            +   E  ++    L  IE  + G  DL  P R FL++  +++V     ++ R LFL  D+
Sbjct: 1255 VRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDL 1314

Query: 1140 LL-YTYPQKDGKYRLKN-TLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDE 1197
            ++  T  +K G  R  + +L  A   +      K+ + L +E ++  ++  AS    R+ 
Sbjct: 1315 IVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDAD--IIKGASQATNREN 1372

Query: 1198 WYGCLSRALPED 1209
                +SR L ED
Sbjct: 1373 IQKAISR-LDED 1383


>gi|13375827 phafin 2 [Homo sapiens]
          Length = 249

 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)

Query: 1090 NLQKLVHIEHSVRGQGDLLQ-PGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLY-TYPQK 1147
            N +++  +E+     G  L  PGR  + EG L K+  K  + R  FL ND+L+Y     +
Sbjct: 11   NTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQ 70

Query: 1148 DGKYRLKNTLAVANMKVSRPVME-KVPYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206
              KY  ++ + + N+ +     E  +     I+T      + A++  E+ EW   +++ +
Sbjct: 71   KKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV 130

Query: 1207 PEDYKAQALAAFHHSVEIRERLGVS-LGERPPTLVPVTHVMMCMNCG-CDFSLTLRRHHC 1264
                            ++  + G +   E     VP +   +CM C    F+   RRHHC
Sbjct: 131  ---------------TDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHC 175

Query: 1265 HACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSS 1324
              CG +VC  CS  ++ L     +  ++CD C+  L     A       R  S S  L S
Sbjct: 176  RKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGDMAT--CQPARSDSYSQSLKS 233

Query: 1325 P 1325
            P
Sbjct: 234  P 234


>gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]
          Length = 1539

 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 14/152 (9%)

Query: 1229 GVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDR 1288
            G+ LG++ PT VP +    CMNC   F+ T RRHHC ACGK+ C  C   K  L+YL ++
Sbjct: 734  GLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYL-EK 792

Query: 1289 MAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQK 1348
             A+VC  C+  + K  +A   +M     ++           S  S    ++ P    +  
Sbjct: 793  EARVCVVCYETISK-AQAFERMMSPTGSNLK----------SNHSDECTTVQPPQENQTS 841

Query: 1349 KVPSALTEVAASGEGSAISGYLSRCKRGKRHW 1380
             +PS  T   ++ +   + G  S  K  KR W
Sbjct: 842  SIPSPATLPVSALKQPGVEGLCS--KEQKRVW 871


>gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens]
          Length = 1539

 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 14/152 (9%)

Query: 1229 GVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDR 1288
            G+ LG++ PT VP +    CMNC   F+ T RRHHC ACGK+ C  C   K  L+YL ++
Sbjct: 734  GLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYL-EK 792

Query: 1289 MAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQK 1348
             A+VC  C+  + K  +A   +M     ++           S  S    ++ P    +  
Sbjct: 793  EARVCVVCYETISK-AQAFERMMSPTGSNLK----------SNHSDECTTVQPPQENQTS 841

Query: 1349 KVPSALTEVAASGEGSAISGYLSRCKRGKRHW 1380
             +PS  T   ++ +   + G  S  K  KR W
Sbjct: 842  SIPSPATLPVSALKQPGVEGLCS--KEQKRVW 871


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
            exchange factor [Homo sapiens]
          Length = 1386

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 108/462 (23%), Positives = 188/462 (40%), Gaps = 37/462 (8%)

Query: 891  SRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELP 950
            SR   +A+E++ +E+AYV  L+ +  D+ G ++         G   L+ E++    + + 
Sbjct: 101  SRLERVAREIVETERAYVRDLRSIVEDYLGPLLDG-------GVLGLSVEQVGTLFANIE 153

Query: 951  AIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLH 1010
             I++    +LE+LE    N  S   +A+ F+ R + FD +  + + +   L LL E  L 
Sbjct: 154  DIYEFSSELLEDLE----NSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS 209

Query: 1011 SPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLC--PDSAEYDNTQ 1068
             P  AA   +  Q+    S   +  LL+ VQR+ +Y +LL +   +    P +   +  +
Sbjct: 210  PP--AALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVE 267

Query: 1069 GALSLISKVTDRANDSMEQGENLQKLVHIEHSVRG-QGDLLQPGREFLKEGTLMKVTGKN 1127
             A+  ++ V    ND   + E+  +L  ++  + G  G  L    E + EG      G  
Sbjct: 268  EAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGG 327

Query: 1128 RR----PRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALK-IETSE 1182
             R     R LFL + +LL    ++  +Y  K  +   N+ VS    + + + +  +   +
Sbjct: 328  PRLRGGERLLFLFSRMLLVA-KRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIPK 386

Query: 1183 SCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPV 1242
               +L A +  E+  W  CL R   E++ A ++ A    V +   L  +  +  P L P+
Sbjct: 387  HRHLLQAKNQEEKRLWIHCLQRLFFENHPA-SIPAKAKQVLLENSLHCA-PKSKPVLEPL 444

Query: 1243 THVMMCMNCGCDFSLTL-RRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELK 1301
            T  +         S T  RR+   + G  V R   R   P+K       +     F    
Sbjct: 445  TPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAG 504

Query: 1302 KRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPST 1343
              G   P            P S P  SGSA     +   P T
Sbjct: 505  SEGELYP------------PESQPPVSGSAPPEDLEDAGPPT 534


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 66/258 (25%), Positives = 117/258 (45%), Gaps = 17/258 (6%)

Query: 894  LVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIH 953
            L +  E+L +E+ YV  L+ L   F   + + + D   +G   L  E ++   S +  I 
Sbjct: 51   LCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKG---LTEENVKVLFSNIEDIL 107

Query: 954  DLHQGILEELEERLS-NWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSP 1012
            ++H+  L  LE  L    +SQ ++ +VFL  +  F  +  +    ++ L LL E      
Sbjct: 108  EVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVEL----- 162

Query: 1013 RLAAAVREFEQSVQ--GGSQTA----KHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDN 1066
                 VR F  S    GG +T     +  LL  +QR+ +Y +LL +          ++  
Sbjct: 163  NKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPA 222

Query: 1067 TQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQ--GDLLQPGREFLKEGTLMKVT 1124
             Q AL  +  V    N++  Q E L+ L  ++  + G    +L     + L +GTL+K++
Sbjct: 223  VQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS 282

Query: 1125 GKNRRPRHLFLMNDVLLY 1142
              N + R  FL +++L+Y
Sbjct: 283  AGNIQERAFFLFDNLLVY 300


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 67/293 (22%), Positives = 126/293 (43%), Gaps = 24/293 (8%)

Query: 865  DEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSS----EKAYVEMLQHLNLDFHG 920
            +EEQ    + D    +  +T   EG S+  V+ + +L S    EK YV+ L+ +   +  
Sbjct: 365  EEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYE- 423

Query: 921  AVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVF 980
               + L +M+ +    L+  +L+     +  I   H      L  R+S W+S + + DVF
Sbjct: 424  ---KPLSEMEPK---VLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVF 477

Query: 981  LA---REQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLL 1037
            +A   +    D ++ ++  F   + +L + C   P     +++ EQ       T    ++
Sbjct: 478  VASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQ-EQEASPDRTTLYSLMM 536

Query: 1038 RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHI 1097
            + +QR  Q+ +LL D L N      +    Q AL+ +  + ++ N+     +   ++  I
Sbjct: 537  KPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQI 596

Query: 1098 EHSV--RGQGDLLQPGREFLKEGTLMKVTGKNRR-------PRHLFLMNDVLL 1141
              ++  R    LL  G  +L     M  T  N R        R +F++NDVL+
Sbjct: 597  AKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLM 649


>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
            [Homo sapiens]
          Length = 883

 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 61/257 (23%), Positives = 111/257 (43%), Gaps = 11/257 (4%)

Query: 890  QSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSEL 949
            QS    +A+EL  +E  YV +L  +   F       L++    G   LA EE++     +
Sbjct: 419  QSARWQVAKELYQTESNYVNILATIIQLFQVP----LEEEGQRGGPILAPEEIKTIFGSI 474

Query: 950  PAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENC- 1008
            P I D+H  I ++LE+ + NW+  + + D+FL   +         + F          C 
Sbjct: 475  PDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCE 534

Query: 1009 LHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQ 1068
               PR  A ++  +   + G Q+    L+R VQRL    +LL D   +   ++ +    +
Sbjct: 535  KQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 594

Query: 1069 GALSLISKVTDRANDSMEQGENLQKLVHIEHSVRG-QGDLLQPGREFLKEGTLMKVTGKN 1127
             A+  + +V    N+   + E  +++  + + V G   +LL   R  ++    + + G++
Sbjct: 595  KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISL-GEH 653

Query: 1128 RRPR----HLFLMNDVL 1140
               R     LFL ND L
Sbjct: 654  PCDRGEQVTLFLFNDCL 670


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 75/251 (29%), Positives = 94/251 (37%), Gaps = 19/251 (7%)

Query: 77   EPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGE 136
            E K+EG       V  E    E EE EE GE    EG G  E+       G G    EGE
Sbjct: 806  EEKEEGGEVEGGEV--EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863

Query: 137  EGTDLALEDEGEGCADE---PGTLEQVSRSEEEEKLVQPHRECSLEDSG-PWAGEGVFQS 192
            EG      +EGEG  +E    G  E+    E EE+  +   E   E  G    GEG  + 
Sbjct: 864  EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE- 922

Query: 193  DLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEE 252
                     E+ E  +  GE EE + EG         +EG       E  G+  E+   E
Sbjct: 923  ---------EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGE 973

Query: 253  PPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATL 312
              E E     +E E   +  E  EEG EE  G   GE     E    E +   EV     
Sbjct: 974  GEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE---EEGEVEGEVEGEEG 1030

Query: 313  EDHAQDESAEE 323
            E   ++E  EE
Sbjct: 1031 EGEGEEEEGEE 1041



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 77/266 (28%), Positives = 107/266 (40%), Gaps = 29/266 (10%)

Query: 74   REDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSR 133
            R +E ++ G V    +   +   EEEEE  EG E    EG G  E+       G G    
Sbjct: 804  RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE---EGEGEEEEGEGEEEEGEGKGEE 860

Query: 134  EGEEGTDLALEDEGEGCADEP---GTLEQVSRSEEEEKLVQPHRECSLEDSGPWA-GEGV 189
            EGEEG      +EGEG  +E    G  E+    E EE+  +   E   E  G    GEG 
Sbjct: 861  EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920

Query: 190  FQSDLLLPHIHGEDQEPP----DTPGEAEE-------DDEEGCASTDPAGADEGSGPDRP 238
             + +       GE++E      D  GE EE       ++EEG    +  G +EG G    
Sbjct: 921  GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG----EGEGEEEGEGEGEE 976

Query: 239  TEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPD 298
             E  G++ E   E   E+ E  G +E E      E   EG EE  G   GE     E  +
Sbjct: 977  GEGEGEEEEGEGEGEEEEGEEEGEEEGEGE---EEGEGEGEEEEEGEVEGE----VEGEE 1029

Query: 299  HEKKTNQEVAAATLEDHAQDESAEES 324
             E +  +E      E+  ++   EE+
Sbjct: 1030 GEGEGEEEEGEEEGEEREKEGEGEEN 1055



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 68/226 (30%), Positives = 89/226 (39%), Gaps = 10/226 (4%)

Query: 75   EDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGE-DSVAPAAPGAGALSR 133
            E E ++EG  G       E   E EEE E  GE    EG G  E +       G G    
Sbjct: 864  EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE 923

Query: 134  EGEEGTDLALEDEGEGCADE---PGTLEQVSRSEEEEKLVQPHRECSLEDSGPWAGE-GV 189
            EGEEG     E+EGEG  ++    G  E+     EEE+      E   E+ G   GE G 
Sbjct: 924  EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE-----GEGEGEEEGEGEGEEGE 978

Query: 190  FQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDT 249
             + +       GE++E  +   E  E +EEG    +     E  G     E  G+  E+ 
Sbjct: 979  GEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEE 1038

Query: 250  SEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSE 295
             EE  E+ E  G  E        E  EEG  + TG    E+ D  E
Sbjct: 1039 GEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 73/255 (28%), Positives = 97/255 (38%), Gaps = 27/255 (10%)

Query: 76   DEPKDEGSVGNKALVSPESSAEEE----EEREEGGEACGLEGTGAGEDSVAPAAPGAGAL 131
            +  K+EG    +     E   EEE    E  EE  E  G E    GE        G G  
Sbjct: 767  EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826

Query: 132  SREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQ 191
              E EEG     E+EGEG  +E    E+    + EE+  +   E   E+     GEG  +
Sbjct: 827  EEEEEEGE--GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE---EEGEEGEGEGEEE 881

Query: 192  SDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSE 251
                     GE +   +  GE EE++ EG       G +EG G     E  G+  E+  E
Sbjct: 882  --------EGEGEGEEEGEGEGEEEEGEG------EGEEEGEGEGEEEEGEGKGEEEGEE 927

Query: 252  EPPEKEELAGVQEAETATDCPEVLEEG---CEEATGVTGGEQVDLSEPPDHEKKTNQEVA 308
               E EE  G  E E      E  EEG    EE  G   GE+    E  + E +  +E  
Sbjct: 928  GEGEGEEEEGEGEGEDGEGEGEE-EEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986

Query: 309  AATLEDHAQDESAEE 323
                E+   +E  EE
Sbjct: 987  EGEGEEEEGEEEGEE 1001



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 69/274 (25%), Positives = 100/274 (36%), Gaps = 31/274 (11%)

Query: 71  VPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGA 130
           V + E++   E S GN  +   E  A EE  +  GG     E         A  + G   
Sbjct: 584 VEIPEEKEGAEDSKGN-GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAK 642

Query: 131 LSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEK---------LVQPHR-ECSLED 180
              E E+G     E  G+G  +E  +  +  + EE EK         + +P   E  L +
Sbjct: 643 SVGEAEDGP----EGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698

Query: 181 SGPWA---GEGVFQSDLLLPHIHGEDQEPPDT------PGEAEEDDEEGCASTDPAGADE 231
              W    GE   Q +    H    +QE  +        GE EE D E     +  G +E
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEE 758

Query: 232 GSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLE---EGCEEATGVTGG 288
           G G +   E   ++ E   EE   KEE  G +E +      E  E   E  EE   V GG
Sbjct: 759 GEGEEVEGEREKEEGERKKEERAGKEE-KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGG 817

Query: 289 EQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAE 322
           E   + E     ++  +E      E   ++E  E
Sbjct: 818 E---VEEGKGEREEEEEEGEGEEEEGEGEEEEGE 848


>gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Homo
            sapiens]
          Length = 1366

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 36/96 (37%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 1205 ALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHC 1264
            AL  D     L A    +  R+    +LGE  P  VP +    CM C   F+ T RRHHC
Sbjct: 663  ALAPDSPDNDLRAGQFGISARKPF-TTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHC 721

Query: 1265 HACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGEL 1300
             ACGK+ C +C   K  L Y+  + A+VC  C   L
Sbjct: 722  RACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVL 757


>gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Homo
            sapiens]
          Length = 1425

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 36/96 (37%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 1205 ALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHC 1264
            AL  D     L A    +  R+    +LGE  P  VP +    CM C   F+ T RRHHC
Sbjct: 663  ALAPDSPDNDLRAGQFGISARKPF-TTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHC 721

Query: 1265 HACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGEL 1300
             ACGK+ C +C   K  L Y+  + A+VC  C   L
Sbjct: 722  RACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVL 757


>gi|6552337 zinc finger, FYVE domain containing 9 isoform 2 [Homo
            sapiens]
          Length = 762

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 36/96 (37%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 1205 ALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHC 1264
            AL  D     L A    +  R+    +LGE  P  VP +    CM C   F+ T RRHHC
Sbjct: 663  ALAPDSPDNDLRAGQFGISARKPF-TTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHC 721

Query: 1265 HACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGEL 1300
             ACGK+ C +C   K  L Y+  + A+VC  C   L
Sbjct: 722  RACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVL 757


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 75/340 (22%), Positives = 142/340 (41%), Gaps = 42/340 (12%)

Query: 879  RDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLA 938
            ++P    K +     + +  EL+ +EK YV+ L  +   F   +       D  G+D + 
Sbjct: 1916 KNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIV 1975

Query: 939  REELRQGLSELPAIHDLHQGI-LEELEERLSNWESQQKVADVFLAREQGFDHHATHILQF 997
               + Q       I+D H+   L ELE+ +   + Q ++A +F+  E             
Sbjct: 1976 FGNIHQ-------IYDWHKDFFLAELEKCI---QEQDRLAQLFIKHE------------- 2012

Query: 998  DRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRL------LRVVQRLFQYQVLLT 1051
             R L +    C + PR    V E++   +   Q    RL      ++ +QR+ +YQ+LL 
Sbjct: 2013 -RKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLK 2071

Query: 1052 DYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPG 1111
            D+L        E  + + A+ L+  V  R ND M    NL +L   E ++  QG LLQ  
Sbjct: 2072 DFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMM----NLGRLQGFEGTLTAQGKLLQQD 2127

Query: 1112 REFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGK----YRLKNTLAVANMKVSRP 1167
              ++ E  L        + R +FL   +++++   + G     Y  K ++ +  + +   
Sbjct: 2128 TFYVIE--LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEEN 2185

Query: 1168 V-MEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206
            V  +   +AL    +   ++L A++   +  W   +++ L
Sbjct: 2186 VDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVL 2225



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 92/372 (24%), Positives = 157/372 (42%), Gaps = 59/372 (15%)

Query: 860  EDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALV-----IAQELLSSEKAYVEMLQHL 914
            +DL  D    S  + +   RD +  H+V  + R        I  ELL +EKAYV      
Sbjct: 1246 KDLELDIIPASLSDREVKLRDAN--HEVNEEKRKSARKKEFIMAELLQTEKAYVR----- 1298

Query: 915  NLDFHGAVMRALDDMDHEGRDTLAREELRQGL--------SELPAIHDLHQGI-LEELEE 965
              D H  +   L +M      T   EE+  G+          +  I+D H  I L+ELE+
Sbjct: 1299 --DLHECLETYLWEM------TSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEK 1350

Query: 966  RLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSV 1025
                 +  + V   F+     F  + T+         L+ E+       A    +  Q  
Sbjct: 1351 YE---QLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEH-------AGTFFDEIQQR 1400

Query: 1026 QGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSM 1085
             G + +    L++ VQR+ +YQ+LL + L   C +  + +   G L ++  V  +AND+M
Sbjct: 1401 HGLANSISSYLIKPVQRITKYQLLLKELLT--CCEEGKGELKDG-LEVMLSVPKKANDAM 1457

Query: 1086 EQGENLQKLVHIEHSVRGQGDL-LQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTY 1144
                ++  L   + ++  QG+L LQ   +     +L+    +  R RHLFL    L+++ 
Sbjct: 1458 ----HVSMLEGFDENLDVQGELILQDAFQVWDPKSLI----RKGRERHLFLFEISLVFSK 1509

Query: 1145 PQKDG----KYRLKNTLAVANMKVSRPVM-EKVPYAL---KIETSESCLMLSASSCAERD 1196
              KD     KY  KN L  + + V+  V  +   +AL   +  +S++  +L AS+   + 
Sbjct: 1510 EIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQ 1569

Query: 1197 EWYGCLSRALPE 1208
            EW   +   + E
Sbjct: 1570 EWIKNIREVIQE 1581


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 75/340 (22%), Positives = 142/340 (41%), Gaps = 42/340 (12%)

Query: 879  RDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLA 938
            ++P    K +     + +  EL+ +EK YV+ L  +   F   +       D  G+D + 
Sbjct: 219  KNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIV 278

Query: 939  REELRQGLSELPAIHDLHQGI-LEELEERLSNWESQQKVADVFLAREQGFDHHATHILQF 997
               + Q       I+D H+   L ELE+ +   + Q ++A +F+  E             
Sbjct: 279  FGNIHQ-------IYDWHKDFFLAELEKCI---QEQDRLAQLFIKHE------------- 315

Query: 998  DRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRL------LRVVQRLFQYQVLLT 1051
             R L +    C + PR    V E++   +   Q    RL      ++ +QR+ +YQ+LL 
Sbjct: 316  -RKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLK 374

Query: 1052 DYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPG 1111
            D+L        E  + + A+ L+  V  R ND M    NL +L   E ++  QG LLQ  
Sbjct: 375  DFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMM----NLGRLQGFEGTLTAQGKLLQQD 430

Query: 1112 REFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGK----YRLKNTLAVANMKVSRP 1167
              ++ E  L        + R +FL   +++++   + G     Y  K ++ +  + +   
Sbjct: 431  TFYVIE--LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEEN 488

Query: 1168 V-MEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206
            V  +   +AL    +   ++L A++   +  W   +++ L
Sbjct: 489  VDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVL 528


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 91/422 (21%), Positives = 170/422 (40%), Gaps = 61/422 (14%)

Query: 773  DYENIPAMNSDYENIQIPPRRPA--RAGAFTKL-FEDQSRALSTANENDGYVDMSSFNAF 829
            D    PA+  D     +P   P   + GA   L +ED  RA +     D     S F ++
Sbjct: 118  DRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESY 177

Query: 830  ------ESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQR-------------- 869
                  E+K +   + A+   +   K+  +  AA        E+ R              
Sbjct: 178  SEDSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKD 237

Query: 870  ---SSEEEDSASRDPSVTH----------KVEGQSRALVIAQELLSS----EKAYVEMLQ 912
                SEEED    + SV+             EG S   V+ + +L S    E +YVE L+
Sbjct: 238  VLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLK 297

Query: 913  HLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWES 972
             +  D+   +M    +M+ +       + +   + E+   H + Q     L  R++ W+S
Sbjct: 298  RILQDYRNPLM----EMEPKALSARKCQVVFFRVKEILHCHSMFQ---IALSSRVAEWDS 350

Query: 973  QQKVADVFLA---REQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGS 1029
             +K+ D+F+A   +    D ++ ++  F   + ++ + CL  P     ++   Q      
Sbjct: 351  TEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKR-RQVCSPDR 409

Query: 1030 QTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGE 1089
             T    +++ +QR  Q+ +LL D L N      +  + Q AL+ +  + ++ N+     +
Sbjct: 410  VTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLAD 469

Query: 1090 NLQKLVHIEHSVRGQGD---LLQPG-REFLKEGTLMKVTGKNR------RPRHLFLMNDV 1139
             + ++  +  SV  +     LL  G R+ L   TL +    +R      + R +FL+ND+
Sbjct: 470  QVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDM 529

Query: 1140 LL 1141
            L+
Sbjct: 530  LV 531


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.130    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,435,343
Number of Sequences: 37866
Number of extensions: 3372169
Number of successful extensions: 16782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 587
Number of HSP's that attempted gapping in prelim test: 13293
Number of HSP's gapped (non-prelim): 3012
length of query: 1462
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1347
effective length of database: 13,892,928
effective search space: 18713774016
effective search space used: 18713774016
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.