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Search of human proteins with 193211603
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193211603 pleckstrin homology domain containing, family G
(with RhoGef domain) member 4 isoform 2 [Homo sapiens]
(1110 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193211603 pleckstrin homology domain containing, family G (wi... 2237 0.0
gi|193211598 pleckstrin homology domain containing, family G (wi... 2042 0.0
gi|193211596 pleckstrin homology domain containing, family G (wi... 2042 0.0
gi|193211594 pleckstrin homology domain containing, family G (wi... 2042 0.0
gi|55742734 pleckstrin homology domain containing, family G (wit... 2042 0.0
gi|148529025 pleckstrin homology domain containing, family G (wi... 427 e-119
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 383 e-106
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 194 4e-49
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 188 3e-47
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 188 3e-47
gi|71274186 hypothetical protein LOC85449 [Homo sapiens] 182 1e-45
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 182 2e-45
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 182 2e-45
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 178 3e-44
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 176 8e-44
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 176 8e-44
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 175 2e-43
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 175 2e-43
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 127 4e-29
gi|71274148 pleckstrin homology domain containing, family G (wit... 125 3e-28
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 114 7e-25
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 114 7e-25
gi|55749621 pleckstrin homology domain containing, family G, mem... 79 2e-14
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 77 9e-14
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 74 6e-13
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 68 4e-11
gi|39930351 dynamin binding protein [Homo sapiens] 67 1e-10
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 61 7e-09
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 60 1e-08
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 60 1e-08
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 2238 bits (5798), Expect = 0.0
Identities = 1110/1110 (100%), Positives = 1110/1110 (100%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
Query: 121 DVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSS 180
DVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSS
Sbjct: 121 DVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSS 180
Query: 181 SLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 240
SLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG
Sbjct: 181 SLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 240
Query: 241 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLM 300
GLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLM
Sbjct: 241 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLM 300
Query: 301 QQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ 360
QQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ
Sbjct: 301 QQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ 360
Query: 361 SNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQV 420
SNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQV
Sbjct: 361 SNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQV 420
Query: 421 AQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQL 480
AQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQL
Sbjct: 421 AQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQL 480
Query: 481 FREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAI 540
FREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAI
Sbjct: 481 FREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAI 540
Query: 541 RQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRN 600
RQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRN
Sbjct: 541 RQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRN 600
Query: 601 LGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMV 660
LGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMV
Sbjct: 601 LGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMV 660
Query: 661 ATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACT 720
ATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACT
Sbjct: 661 ATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACT 720
Query: 721 RHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLL 780
RHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLL
Sbjct: 721 RHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLL 780
Query: 781 KPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNL 840
KPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNL
Sbjct: 781 KPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNL 840
Query: 841 KEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGL 900
KEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGL
Sbjct: 841 KEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGL 900
Query: 901 TECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEM 960
TECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEM
Sbjct: 901 TECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEM 960
Query: 961 VSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPG 1020
VSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPG
Sbjct: 961 VSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPG 1020
Query: 1021 DPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQ 1080
DPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQ
Sbjct: 1021 DPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQ 1080
Query: 1081 CPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
CPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1081 CPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2042 bits (5290), Expect = 0.0
Identities = 1047/1191 (87%), Positives = 1063/1191 (89%), Gaps = 81/1191 (6%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DVQGRAVL--------LLCAHSPAWLQSECSS-----QELIRLLLYLRS---IPRP---- 160
D G ++ + SP L S+ E+ +LL S +P+P
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 161 -------EVQALGLTVLVDAR---------ICAPSSSLFS-------------------- 184
E+ A G+ L R +CA S +
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 185 ------GLSQLQEAAPGAVYQVLLVGSTLLKE-------------------VPSGLQLEQ 219
GL+ L +A A L G + L+E VPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 220 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 279
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 280 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 339
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 340 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 399
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 400 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 459
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 460 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 519
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 520 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 579
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 580 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 639
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 640 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 699
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 759
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 760 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 819
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 820 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 879
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 880 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 940 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 999
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1000 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1059
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1060 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2042 bits (5290), Expect = 0.0
Identities = 1047/1191 (87%), Positives = 1063/1191 (89%), Gaps = 81/1191 (6%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DVQGRAVL--------LLCAHSPAWLQSECSS-----QELIRLLLYLRS---IPRP---- 160
D G ++ + SP L S+ E+ +LL S +P+P
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 161 -------EVQALGLTVLVDAR---------ICAPSSSLFS-------------------- 184
E+ A G+ L R +CA S +
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 185 ------GLSQLQEAAPGAVYQVLLVGSTLLKE-------------------VPSGLQLEQ 219
GL+ L +A A L G + L+E VPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 220 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 279
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 280 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 339
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 340 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 399
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 400 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 459
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 460 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 519
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 520 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 579
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 580 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 639
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 640 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 699
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 759
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 760 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 819
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 820 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 879
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 880 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 940 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 999
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1000 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1059
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1060 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2042 bits (5290), Expect = 0.0
Identities = 1047/1191 (87%), Positives = 1063/1191 (89%), Gaps = 81/1191 (6%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DVQGRAVL--------LLCAHSPAWLQSECSS-----QELIRLLLYLRS---IPRP---- 160
D G ++ + SP L S+ E+ +LL S +P+P
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 161 -------EVQALGLTVLVDAR---------ICAPSSSLFS-------------------- 184
E+ A G+ L R +CA S +
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 185 ------GLSQLQEAAPGAVYQVLLVGSTLLKE-------------------VPSGLQLEQ 219
GL+ L +A A L G + L+E VPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 220 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 279
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 280 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 339
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 340 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 399
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 400 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 459
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 460 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 519
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 520 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 579
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 580 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 639
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 640 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 699
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 759
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 760 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 819
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 820 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 879
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 880 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 940 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 999
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1000 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1059
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1060 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2042 bits (5290), Expect = 0.0
Identities = 1047/1191 (87%), Positives = 1063/1191 (89%), Gaps = 81/1191 (6%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DVQGRAVL--------LLCAHSPAWLQSECSS-----QELIRLLLYLRS---IPRP---- 160
D G ++ + SP L S+ E+ +LL S +P+P
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 161 -------EVQALGLTVLVDAR---------ICAPSSSLFS-------------------- 184
E+ A G+ L R +CA S +
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 185 ------GLSQLQEAAPGAVYQVLLVGSTLLKE-------------------VPSGLQLEQ 219
GL+ L +A A L G + L+E VPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 220 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 279
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 280 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 339
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 340 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 399
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 400 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 459
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 460 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 519
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 520 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 579
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 580 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 639
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 640 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 699
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 759
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 760 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 819
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 820 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 879
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 880 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 940 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 999
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1000 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1059
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1060 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 427 bits (1099), Expect = e-119
Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)
Query: 634 ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 690
+SP+ P D R +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 785 SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
Query: 691 RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 750
RG+ +FGNLEKL DFH FLRELE C P V +FLRH QFGMY +YSKNKP+S
Sbjct: 845 RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
Query: 751 DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 807
DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L + +CG QEL
Sbjct: 905 DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
Query: 808 SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 867
LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL +DEF+V GR K +R +FL
Sbjct: 965 GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
Query: 868 FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 926
FE+L+LFSK + D + YK+SFK A++G+TE G+S LRFEIWF RRRK++DT++L
Sbjct: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
Query: 927 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 978
QASS +K AWT I +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +
Sbjct: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
Query: 979 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1025
++DR + ++K E + R S AV+ DH + + + S++ S
Sbjct: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
Query: 1026 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1070
S+LGSL L + PA GL P + + EE E E E G Q ++
Sbjct: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
Score = 152 bits (384), Expect = 2e-36
Identities = 108/316 (34%), Positives = 161/316 (50%), Gaps = 12/316 (3%)
Query: 118 GTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICA 177
GTRD GRAV+ + S W + S EL RLLLY SIPR EV+ LGL VLVDAR
Sbjct: 207 GTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSP 266
Query: 178 PSSSLFSGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAG 233
+ ++ LS LQ ++ +LL+ S + + +Q E + S +++ + +
Sbjct: 267 AAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQ 326
Query: 234 LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLL 293
L L G PY H W+ FR+RLE NC+ A LQ + S+ P EV +L+
Sbjct: 327 LTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELI 386
Query: 294 QQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGL 353
Q E +M+ VL+ P L L+ +GG L L++ E + D R ++ A LYDRVD
Sbjct: 387 DQHETMMKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEE 443
Query: 354 LHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGS 413
+H+L L SN R+Q LE ++ L + G Q Q G +E + + +M+ +
Sbjct: 444 VHRLVLTSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRG 500
Query: 414 FQELYQVAQEQVRQGE 429
+ V+Q + R+GE
Sbjct: 501 LSAV--VSQAECREGE 514
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 383 bits (984), Expect = e-106
Identities = 321/976 (32%), Positives = 465/976 (47%), Gaps = 119/976 (12%)
Query: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
M+S + G D GRA+L + P + S L L YL S+ RP++Q LGL+
Sbjct: 531 MASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHYLHSLLRPDLQTLGLS 589
Query: 169 VLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPS---GLQLEQLPSQS 224
VL+D R P +L LSQLQ++ + Q LL+ + ++P+ G Q ++ S++
Sbjct: 590 VLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLPTELCGFQGAEVLSEN 647
Query: 225 LLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQP 283
L + L LGG W++ + + L + CQ ++ AIE ++ +P
Sbjct: 648 DLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEP 707
Query: 284 MEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKA 343
E VG +Q+VL P L LQ GG L L+ +P +
Sbjct: 708 EEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS-------TPSSKLEGQGP 755
Query: 344 DELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEP- 402
LY VD +HQL SN +Q E Q L L Q+ WL G L P
Sbjct: 756 ATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWLSGPGEEQLASFAMPG 811
Query: 403 -SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFS 461
+L L + + F+ QE++ Q + L A E + + L + F
Sbjct: 812 DTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENATSQKVLDI------FE 858
Query: 462 RALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLP 521
+ L Q L A RL + F++A W +EG A L PG L R P+
Sbjct: 859 QRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGREAVLAALALRRAPEPS 915
Query: 522 PAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EASLK------------ 567
F++M ALA LGS A +E ARCQ+ + Q + EAS +
Sbjct: 916 AGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASS 975
Query: 568 -------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLGQSLSEPA-------- 609
P S +SL + P AP+H L G L+ A
Sbjct: 976 GGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAV 1035
Query: 610 ----------------CHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQ 653
C + R P+ G V P RS++ Q
Sbjct: 1036 LIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------VGTPRMERKRSISAQQ 1087
Query: 654 LVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFL 713
+++E++A E++YV L + PEL P+ LRG A E+LR FH FL
Sbjct: 1088 RLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAALSARERLRSFHRTHFL 1142
Query: 714 RELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHL 773
REL+ C HP R+ FLRH QF +YA Y K++ + + +++ K +A G +L
Sbjct: 1143 RELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS-PLSKGSMEA-GPYL 1200
Query: 774 DLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLVHFQLRHGNDLLAMDA 832
A L +P++++ +Y LL+EL R G + E AL A L+ Q G DLLA++A
Sbjct: 1201 PRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEA 1258
Query: 833 IQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRS 892
++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK + G + F YK++
Sbjct: 1259 VRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQA 1318
Query: 893 FKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHN 952
FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK WT+ I+ LLWRQA HN
Sbjct: 1319 FKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHN 1378
Query: 953 KEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYL 1012
KE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+RAS+AV+ F+H
Sbjct: 1379 KELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTRASVAVSSFEH----- 1429
Query: 1013 GASNSLPG-DPASCSV 1027
A SLPG P +CS+
Sbjct: 1430 -AGPSLPGLSPGACSL 1444
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 194 bits (493), Expect = 4e-49
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 648 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 707
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
Query: 708 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 767
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
Query: 768 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 827
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
Query: 828 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 881
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
Query: 882 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
Query: 940 DISHLLWRQ 948
+I+ +L Q
Sbjct: 2265 EINQILENQ 2273
Score = 174 bits (442), Expect = 3e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
Query: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
Query: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
Query: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
Query: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
Query: 937 WTADISHLLWRQAVHNK 953
W I ++ + +H K
Sbjct: 1582 WIKHIREVIQERTIHLK 1598
Score = 50.4 bits (119), Expect = 9e-06
Identities = 64/287 (22%), Positives = 119/287 (41%), Gaps = 30/287 (10%)
Query: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
+ ++ G RD +G +L A S ++L RL+ YL IP EV G T
Sbjct: 69 LKEKVAYLSGGRDKRGGPILTFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFT 125
Query: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQL 220
V+VD R + S+ L LQE+ P ++ L++ T + +
Sbjct: 126 VIVDMR-GSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMV 184
Query: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVK 278
+ L + + L G L Y H+ W++ R E + N + L+ I + K
Sbjct: 185 SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKK 244
Query: 279 AVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---S 333
+PQ +E ++++ L ++V+ +P + L +G + L ++ + P+ +
Sbjct: 245 ELPQDLEGAR--NMIEEHSQLKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGN 301
Query: 334 PDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
D + + K + DR+ LHQ+ ++ L+L Q + R
Sbjct: 302 ADLQNLLPKVSTMLDRLHSTRQHLHQM-----WHVRKLKLDQCFQLR 343
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 188 bits (477), Expect = 3e-47
Identities = 221/864 (25%), Positives = 364/864 (42%), Gaps = 75/864 (8%)
Query: 140 SECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQ 199
SE +E ++ YL SIP + +G +++D R +S+ + + ++ + P +
Sbjct: 131 SEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRR-DKWTSVKASVLRIAASFPANLQL 189
Query: 200 VLLVGST------------------LLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGG 241
VL++ T +VP + L +P L +I + L LGG
Sbjct: 190 VLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPV-IMLSSVPD--LHGYIDKSQLTEDLGGT 246
Query: 242 LPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQ 301
L YCH WL R +E+ + +LQ + P + +L
Sbjct: 247 LDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKD 306
Query: 302 QVLDSPWLAWLQCQGGRE-LTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ 360
+ + LA + E L L+ E E +++ D L +++
Sbjct: 307 KAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEF 366
Query: 361 SNQRIQALELVQTLEARESGLHQIEVWLQQVGWP--ALEEAGEP--SLDMLLQAQGSFQE 416
+ Q LE L E G +++ L + G ++ LL+ SF+E
Sbjct: 367 WAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEE 426
Query: 417 LYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAER 476
VA E+ R + L G + +D + LR +FS +A+R L+ +
Sbjct: 427 KSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLE 486
Query: 477 LFQLFREALTWAEEGQRVLAEL------EQERPGVVLQQLQLHWTRHPDLPPAHFRKMWA 530
L + ++ W +EG +LA Q+ LQ+++ + ++
Sbjct: 487 LHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYK 546
Query: 531 LATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPP 590
+ ++ + + R + + Q + + + +ASLK T + P AP
Sbjct: 547 EYESILNQDLMEHVRKVFQK-QASMEEVFHRRQASLKKLAARQTRPV----QPVAPRPEA 601
Query: 591 LRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLN 650
L K+ + + SE + A RR ++ Q + + SL
Sbjct: 602 LAKSPCPSPGIRRG-SENSSSEGGALRRGPYRRAKSEMSESRQGRGSA----GEEEESLA 656
Query: 651 RLQL-VLAEMVATEREYVRALEYTMENYFPELDRPDVPQ----GLRGQRAHLFGNLEKLR 705
L+ V++E++ TER YV L +E Y E+D P + GL ++ LFGN+E++
Sbjct: 657 ILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIY 716
Query: 706 DFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKD 764
FH FLRELE T P V FL F +Y Y +NKPRS++L FF++
Sbjct: 717 HFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE 776
Query: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQL 821
Q+ L L L SYLLKP+QR+ KY LLL+E+ +R C G L+EA S + L
Sbjct: 777 CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAED----LQEALSSILGIL 832
Query: 822 RHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGR---HKSV----------RRIFLF 868
+ ND + + AI G D NL + G+L+ Q F V T H V R +FL
Sbjct: 833 KAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLH 892
Query: 869 EELLLFSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTF 924
E+ +LF K R G +++YK+S MA +G+TE +FEIW+ R+ + +
Sbjct: 893 EKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE--EVY 950
Query: 925 VLQASSLAIKQAWTADISHLLWRQ 948
++QA + IK AW +I +L Q
Sbjct: 951 IVQAPTPEIKAAWVNEIRKVLTSQ 974
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 188 bits (477), Expect = 3e-47
Identities = 221/864 (25%), Positives = 364/864 (42%), Gaps = 75/864 (8%)
Query: 140 SECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQ 199
SE +E ++ YL SIP + +G +++D R +S+ + + ++ + P +
Sbjct: 78 SEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRR-DKWTSVKASVLRIAASFPANLQL 136
Query: 200 VLLVGST------------------LLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGG 241
VL++ T +VP + L +P L +I + L LGG
Sbjct: 137 VLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPV-IMLSSVPD--LHGYIDKSQLTEDLGGT 193
Query: 242 LPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQ 301
L YCH WL R +E+ + +LQ + P + +L
Sbjct: 194 LDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKD 253
Query: 302 QVLDSPWLAWLQCQGGRE-LTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ 360
+ + LA + E L L+ E E +++ D L +++
Sbjct: 254 KAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEF 313
Query: 361 SNQRIQALELVQTLEARESGLHQIEVWLQQVGWP--ALEEAGEP--SLDMLLQAQGSFQE 416
+ Q LE L E G +++ L + G ++ LL+ SF+E
Sbjct: 314 WAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEE 373
Query: 417 LYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAER 476
VA E+ R + L G + +D + LR +FS +A+R L+ +
Sbjct: 374 KSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLE 433
Query: 477 LFQLFREALTWAEEGQRVLAEL------EQERPGVVLQQLQLHWTRHPDLPPAHFRKMWA 530
L + ++ W +EG +LA Q+ LQ+++ + ++
Sbjct: 434 LHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYK 493
Query: 531 LATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPP 590
+ ++ + + R + + Q + + + +ASLK T + P AP
Sbjct: 494 EYESILNQDLMEHVRKVFQK-QASMEEVFHRRQASLKKLAARQTRPV----QPVAPRPEA 548
Query: 591 LRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLN 650
L K+ + + SE + A RR ++ Q + + SL
Sbjct: 549 LAKSPCPSPGIRRG-SENSSSEGGALRRGPYRRAKSEMSESRQGRGSA----GEEEESLA 603
Query: 651 RLQL-VLAEMVATEREYVRALEYTMENYFPELDRPDVPQ----GLRGQRAHLFGNLEKLR 705
L+ V++E++ TER YV L +E Y E+D P + GL ++ LFGN+E++
Sbjct: 604 ILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIY 663
Query: 706 DFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKD 764
FH FLRELE T P V FL F +Y Y +NKPRS++L FF++
Sbjct: 664 HFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE 723
Query: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQL 821
Q+ L L L SYLLKP+QR+ KY LLL+E+ +R C G L+EA S + L
Sbjct: 724 CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAED----LQEALSSILGIL 779
Query: 822 RHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGR---HKSV----------RRIFLF 868
+ ND + + AI G D NL + G+L+ Q F V T H V R +FL
Sbjct: 780 KAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLH 839
Query: 869 EELLLFSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTF 924
E+ +LF K R G +++YK+S MA +G+TE +FEIW+ R+ + +
Sbjct: 840 EKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE--EVY 897
Query: 925 VLQASSLAIKQAWTADISHLLWRQ 948
++QA + IK AW +I +L Q
Sbjct: 898 IVQAPTPEIKAAWVNEIRKVLTSQ 921
>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
Length = 1200
Score = 182 bits (463), Expect = 1e-45
Identities = 157/507 (30%), Positives = 234/507 (46%), Gaps = 55/507 (10%)
Query: 38 ASQMHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGP 97
A K GP P+ T++ K LP A+ +G +RG ++ E P
Sbjct: 517 AGTTQTKTSGPATAPSPLTEE----------KAALPEAS--AGSPERGP----TLEEEPP 560
Query: 98 GPSGVESLLCP--MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLR 155
GP L S ++ G RD GR +LL+ AW C+ E+ +LL YL
Sbjct: 561 GPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLC 620
Query: 156 SIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGL 215
+IPRPE +A GL VL+DAR P L S L Q P ++ +L +G E + L
Sbjct: 621 TIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLG-----EKEAAL 675
Query: 216 QLEQLPS---------QSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAA 266
QL+ LP ++L H+ + LP L G PYCH W+ F ++L+ L + A
Sbjct: 676 QLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQA 735
Query: 267 CALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE 326
+LLQ +IE + P E + L +++ LM+ VL P L LQ +GG L L+ +
Sbjct: 736 SSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHD 795
Query: 327 VPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEV 386
+ SPD R+ + A LY VD LH L SN + LEL L E+ +HQ+
Sbjct: 796 ASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSD 855
Query: 387 WLQQVGWPALEE--AGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQP-----LTGWE 439
W++Q G L+ + SL+ + +A F+ + A Q R+G + + T
Sbjct: 856 WMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARG 915
Query: 440 AAELD----PPGARFL----ALRAQLTEFSRALAQRCQRLADAERLFQLFR--EALTWAE 489
A E + P A F A +A+LT F A A+R + D E L L R + +TW
Sbjct: 916 AGEAERAEFPELAAFASTQRAFQAELTHFYMA-AER--QRTDLETLLHLHRFCKRMTWFH 972
Query: 490 -EGQRVLAELEQERPGVVL--QQLQLH 513
+ Q ++A+L ++ V Q +LH
Sbjct: 973 MDCQDLMAQLRLDKTSRVSPGDQRRLH 999
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 182 bits (461), Expect = 2e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 634 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 691
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 1910 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 1969
Query: 692 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 751
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 1970 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 2029
Query: 752 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 811
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 2030 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 2088
Query: 812 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 865
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 2089 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 2147
Query: 866 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 925
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 2148 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 2205
Query: 926 LQASSLAIKQAWTADISHLLWRQ 948
LQA++ I+QAW DI+ +L Q
Sbjct: 2206 LQAANADIQQAWVQDINQVLETQ 2228
Score = 178 bits (451), Expect = 3e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
Query: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
Query: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
Query: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
Query: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
Query: 937 WTADISHLLWRQAVHNK 953
W +I ++ + +H K
Sbjct: 1571 WIKNIREVIQERIIHLK 1587
Score = 52.4 bits (124), Expect = 2e-06
Identities = 62/288 (21%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
+ ++ G RD +G +L A S ++L +L+ YL S+P +V G T
Sbjct: 39 LKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLASVPSEDVCKRGFT 95
Query: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLLKEVPSGLQLEQL 220
V++D R + + L LQEA P ++ L++ T + +
Sbjct: 96 VIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMV 154
Query: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAV 280
+ L + + L G L Y H+ W++ R LE + + L+ E +
Sbjct: 155 SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARK 214
Query: 281 PQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE--------VPEVTL 332
P++ +L+ + L ++VL +P + L +G R L ++ +P
Sbjct: 215 EFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG--- 270
Query: 333 SPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 271 SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 182 bits (461), Expect = 2e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 634 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 691
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 213 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 272
Query: 692 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 751
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 273 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 332
Query: 752 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 811
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 333 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 391
Query: 812 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 865
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 392 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 450
Query: 866 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 925
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 451 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 508
Query: 926 LQASSLAIKQAWTADISHLLWRQ 948
LQA++ I+QAW DI+ +L Q
Sbjct: 509 LQAANADIQQAWVQDINQVLETQ 531
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 178 bits (451), Expect = 3e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
Query: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
Query: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
Query: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
Query: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
Query: 937 WTADISHLLWRQAVHNK 953
W +I ++ + +H K
Sbjct: 1571 WIKNIREVIQERIIHLK 1587
Score = 52.4 bits (124), Expect = 2e-06
Identities = 62/288 (21%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
+ ++ G RD +G +L A S ++L +L+ YL S+P +V G T
Sbjct: 39 LKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLASVPSEDVCKRGFT 95
Query: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLLKEVPSGLQLEQL 220
V++D R + + L LQEA P ++ L++ T + +
Sbjct: 96 VIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMV 154
Query: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAV 280
+ L + + L G L Y H+ W++ R LE + + L+ E +
Sbjct: 155 SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARK 214
Query: 281 PQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE--------VPEVTL 332
P++ +L+ + L ++VL +P + L +G R L ++ +P
Sbjct: 215 EFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG--- 270
Query: 333 SPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 271 SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 176 bits (447), Expect = 8e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 655 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 710
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
Query: 711 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 769
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
Query: 770 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 826
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
Query: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 873
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
Query: 874 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 929
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
Query: 930 SLAIKQAWTADISHLLWRQ 948
++ +K W +I ++L +Q
Sbjct: 853 NVDVKMTWLKEIRNILLKQ 871
Score = 50.4 bits (119), Expect = 9e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 142 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 200
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
Query: 201 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 245
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
Query: 246 HQAWLDFRRRLEALLQNCQAACALLQ 271
H W+ FR +E + +LQ
Sbjct: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 176 bits (447), Expect = 8e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 655 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 710
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 499 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 558
Query: 711 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 769
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 559 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 618
Query: 770 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 826
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 619 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 674
Query: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 873
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 675 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 734
Query: 874 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 929
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 735 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 792
Query: 930 SLAIKQAWTADISHLLWRQ 948
++ +K W +I ++L +Q
Sbjct: 793 NVDVKMTWLKEIRNILLKQ 811
Score = 37.7 bits (86), Expect = 0.061
Identities = 18/47 (38%), Positives = 23/47 (48%)
Query: 225 LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 271
LLT+I L LGG L YCH W+ FR +E + +LQ
Sbjct: 67 LLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQ 113
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
Length = 580
Score = 175 bits (444), Expect = 2e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
Query: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
Query: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Query: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
Query: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
Query: 936 AWTADISHLLWRQ 948
AW ++ +L Q
Sbjct: 456 AWIKHVAQILESQ 468
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
Length = 619
Score = 175 bits (444), Expect = 2e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
Query: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
Query: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Query: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
Query: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
Query: 936 AWTADISHLLWRQ 948
AW ++ +L Q
Sbjct: 495 AWIKHVAQILESQ 507
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 127 bits (320), Expect = 4e-29
Identities = 204/926 (22%), Positives = 362/926 (39%), Gaps = 157/926 (16%)
Query: 145 QELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG 204
++ + ++ YL SIP E ++G V++D R SS+ + L+++ A PG + + ++
Sbjct: 78 EDFLNVMTYLTSIPSVEAASIGFIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILR 136
Query: 205 STLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAW 249
+ E + + + + S S L +I + L LGG L Y H W
Sbjct: 137 PSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQW 196
Query: 250 LDFRRRLEALLQNCQAACALLQ--GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSP 307
++ R +E + +LQ G+ + +P+ M L ++LM
Sbjct: 197 VNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSM--------LSTEDLLMSHTRQRD 248
Query: 308 WLA-WLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQ 366
L L+ G + T L T P+ + +++ L +T +Q
Sbjct: 249 KLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQ-----------LENVTTMERLLVQ 297
Query: 367 ALELVQTLEARESGLH-QIEVWLQQVGWPALEEAGEPSLDMLLQAQGSF-------QELY 418
E + S H ++ LQ + + +LD LL+ Q F +
Sbjct: 298 LDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVE 357
Query: 419 QVAQEQVRQGEKFLQPLTGWEAAEL-------------DPPGARFLALRAQLTEFSRALA 465
Q+ +E + EK +PL + L D R + LR +F
Sbjct: 358 QILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNK 417
Query: 466 QRCQRLADAERLFQLFREALTWAEEGQRVLAELE----QERPGVVLQQLQLHW-----TR 516
++ L + + + W E G +LA Q R GV + +
Sbjct: 418 KKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKE 477
Query: 517 HPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTW---------LALDQKLEASLK 567
+P L P F + L L ++A Q+ Q+ + LA Q
Sbjct: 478 YPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPV 537
Query: 568 LPPVGSTASLCVSQVP----AAPAHPPLR-------------KAYSFDRNLGQSLSEPAC 610
P S+ S+ + P PLR + D + SE
Sbjct: 538 APHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIF 597
Query: 611 HCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRAL 670
HH E G L Q + G PR + ++ +++ TE Y++ +
Sbjct: 598 ESHH----------ERGNPELEQQARL----GDLSPR-----RRIIRDLLETEEIYIKEI 638
Query: 671 EYTMENYFPELD----RPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRV 726
+ ++ Y +D + +P L+ + LFGN+ +L +FH FL+ELE C +P +
Sbjct: 639 KSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELL 698
Query: 727 AYAFLRHRVQFGMYALYSKNKPRSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQR 785
A+ FL+ + +Y Y KN PR+ A+ +F Q+ L +L L YL P QR
Sbjct: 699 AHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQR 758
Query: 786 MGKYALLLQEL-----------------ARACGGPTQELSA-----LREAQSLVHFQLRH 823
+ KY +LL+ L A GP + + L++A +++ ++
Sbjct: 759 LIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKS 818
Query: 824 GNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRT---GRHK---------SVRRIFLFEEL 871
+ + A+ C ++ + G+L+ F V T R+K S R+I+LFE
Sbjct: 819 CELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERG 878
Query: 872 LLFSKPR--HGPTGVDT-FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQA 928
++F K R G G+ +++K++ K+ L + + S+ +FEI R + ++LQA
Sbjct: 879 IVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQA 936
Query: 929 SSLAIKQAWTADISHLLWRQAVHNKE 954
+S I+ W ++IS LL Q + K+
Sbjct: 937 ASKEIRDCWFSEISKLLMEQQNNIKD 962
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 125 bits (313), Expect = 3e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 622 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 681
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
Query: 682 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 740
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
Query: 741 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 795
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Query: 796 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 843
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
Query: 844 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 903
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
Query: 904 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 945
L F + F + + +QA S K+ W + L+
Sbjct: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 114 bits (284), Expect = 7e-25
Identities = 86/334 (25%), Positives = 161/334 (48%), Gaps = 20/334 (5%)
Query: 635 SPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR-PDVPQGLRGQ 693
+P P S+ RL V+ E++++E+ +V L++ ++ L+R P VP + GQ
Sbjct: 5677 APEFPGEAVSEDEYKARLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQ 5736
Query: 694 RAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDAL 753
+A +F N+ + FH F L+EL+ C VA F++++ F Y + + +++++
Sbjct: 5737 KAVIFRNVRDIGRFHSSF-LQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGRVQAESV 5794
Query: 754 MSSYGHTFFKDK--QQAL--GDHLD-----LASYLLKPIQRMGKYALLLQELARACGGPT 804
+ S F K ++AL GD L YL +P++R+ +Y LL+EL R
Sbjct: 5795 VVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNR 5854
Query: 805 QELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKS--- 861
Q + L +A ++V + + L + ++ L+ G+ +RQ F+V G +
Sbjct: 5855 QNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMP 5914
Query: 862 ----VRRIFLFEELLLFSKPRH-GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFR 916
R +FLF L+ KPR T ++ ++ K++ + L + + FE+W
Sbjct: 5915 WKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQE 5974
Query: 917 RRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 950
R + ++LQA + IK +W +I + R A+
Sbjct: 5975 REDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 114 bits (284), Expect = 7e-25
Identities = 86/334 (25%), Positives = 161/334 (48%), Gaps = 20/334 (5%)
Query: 635 SPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR-PDVPQGLRGQ 693
+P P S+ RL V+ E++++E+ +V L++ ++ L+R P VP + GQ
Sbjct: 5677 APEFPGEAVSEDEYKARLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQ 5736
Query: 694 RAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDAL 753
+A +F N+ + FH F L+EL+ C VA F++++ F Y + + +++++
Sbjct: 5737 KAVIFRNVRDIGRFHSSF-LQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGRVQAESV 5794
Query: 754 MSSYGHTFFKDK--QQAL--GDHLD-----LASYLLKPIQRMGKYALLLQELARACGGPT 804
+ S F K ++AL GD L YL +P++R+ +Y LL+EL R
Sbjct: 5795 VVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNR 5854
Query: 805 QELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKS--- 861
Q + L +A ++V + + L + ++ L+ G+ +RQ F+V G +
Sbjct: 5855 QNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMP 5914
Query: 862 ----VRRIFLFEELLLFSKPRH-GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFR 916
R +FLF L+ KPR T ++ ++ K++ + L + + FE+W
Sbjct: 5915 WKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQE 5974
Query: 917 RRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 950
R + ++LQA + IK +W +I + R A+
Sbjct: 5975 REDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 79.0 bits (193), Expect = 2e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 736 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 790
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
Query: 791 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 839
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
Query: 840 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 898
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
Query: 899 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 945
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 77.0 bits (188), Expect = 9e-14
Identities = 61/164 (37%), Positives = 87/164 (53%), Gaps = 12/164 (7%)
Query: 641 PGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYF-PELDRPDVPQGLRGQRAHLFG 699
PGS+ P +RL+ V E+V TER YVR L +E+Y P LD + + Q LF
Sbjct: 95 PGSARP---SRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVE-QVGTLFA 150
Query: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDAL-----M 754
N+E + +F L +LE + +A F++ F +Y LY N P S AL +
Sbjct: 151 NIEDIYEFSSE-LLEDLEN-SSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSL 208
Query: 755 SSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR 798
S + +++Q L L L S+LLKP+QR+ KY LLLQEL +
Sbjct: 209 SPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGK 252
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 74.3 bits (181), Expect = 6e-13
Identities = 79/289 (27%), Positives = 122/289 (42%), Gaps = 30/289 (10%)
Query: 624 PEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR 683
P A G A P + P R L VL E++ TER+YV L + + + +
Sbjct: 22 PRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQ 81
Query: 684 ---PDVPQGLRGQRAH-LFGNLEKLRDFHCHFFLRELEACTRHPPRVAY----AFLRHRV 735
V +GL + LF N+E + + H F L LE C P+ + FL+ +
Sbjct: 82 NVADSVEKGLTEENVKVLFSNIEDILEVHKDF-LAALEYCLHPEPQSQHELGNVFLKFKD 140
Query: 736 QFGMYALYSKNKPRSDALMSSYGHT----FFKDKQQALGDH----LDLASYLLKPIQRMG 787
+F +Y Y N ++ L+ F LG + L YLL PIQR+
Sbjct: 141 KFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRIC 200
Query: 788 KYALLLQELARACGGPTQE-------LSALREAQSLVHFQLRHGNDLLAMDAIQGC---- 836
KY LLL+ELA+ G + L A++ S ++ R L A++ +Q
Sbjct: 201 KYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGW 260
Query: 837 -DVNLKE-QGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTG 883
NL + QL+ Q + + + R FLF+ LL++ K + TG
Sbjct: 261 EGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTG 309
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/379 (21%), Positives = 154/379 (40%), Gaps = 50/379 (13%)
Query: 651 RLQLVLAEMVATEREYVRALEYTMENYF----PELDRPDVPQGLRGQRAHLFGNLEKLRD 706
+L + E++ TER YV L+ + ++ E +R P + + +F N+ +
Sbjct: 206 KLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK---IFSNISSINA 262
Query: 707 FHCHFFLRELEACTRH---PPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTF-- 761
FH F L ELE + PR+ + MY Y K + L+ +
Sbjct: 263 FHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQ 322
Query: 762 FKD-----KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSL 816
FK ++Q + L L ++L+P+QR+ +Y +LL++ R + + + +++ +
Sbjct: 323 FKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382
Query: 817 VHFQLRHGND----------LLAMDAIQGCDVNL-KEQGQLVRQDEFVVRTGRHKSV--R 863
+ H N LL + + G + ++ +L+++ + + R+ S R
Sbjct: 383 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
Query: 864 RIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT 923
+FLF +LL+ P+ G F + + + + E N + F+ T
Sbjct: 443 YLFLFNNMLLYCVPKFSLVG-SKFTVRTRVGIDGMKIVE---TQNEEYPHTFQVSGKERT 498
Query: 924 FVLQASSLAIKQAWTADIS---------HLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIA 974
LQASS K+ W + H +R A+ +E+ + +G +A R
Sbjct: 499 LELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPR--- 555
Query: 975 PSEEAINDRTVNYVLKCRE 993
I D V +KC+E
Sbjct: 556 ----WIRDNEVTMCMKCKE 570
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 66.6 bits (161), Expect = 1e-10
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 30/185 (16%)
Query: 633 QASPTVPPPGS-----SDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVP 687
Q+S V P GS + R L + V+ E++ TER+Y+R LE +E + + VP
Sbjct: 761 QSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVP 820
Query: 688 Q-GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQF-GMYALYSK 745
G LFGN++ + ++L A V FL HR + G Y +Y +
Sbjct: 821 NIDFEG----LFGNMQMVIKVS-----KQLLAALEISDAVGPVFLGHRDELEGTYKIYCQ 871
Query: 746 NKPRSDALMSSY--GHTFFKDKQQALGD------------HLDLASYLLKPIQRMGKYAL 791
N + AL+ Y K Q +L D +++L S+L+KP+QR+ +Y L
Sbjct: 872 NHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPL 931
Query: 792 LLQEL 796
LL EL
Sbjct: 932 LLMEL 936
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 60.8 bits (146), Expect = 7e-09
Identities = 91/446 (20%), Positives = 174/446 (39%), Gaps = 92/446 (20%)
Query: 621 CRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-------------------------- 654
CR PE+ G P+ V S+PR+++R L
Sbjct: 43 CRPPESPG---PREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGT 99
Query: 655 ------VLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAH-------LFGNL 701
++ E++ TE+ YV L + +F EL + R +A +F N+
Sbjct: 100 QEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKT-----ARSSKAFPEDVVRVIFSNI 154
Query: 702 EKLRDFHCHFFLRELEACTRH---PPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSS-- 756
+ FH FFL EL+ PR+ + MY+ Y KN R+ L+++
Sbjct: 155 SSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWT 214
Query: 757 -----YGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 811
+ + + L L ++L+P+QR+ +Y LLL+E + + + +
Sbjct: 215 DKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQ 274
Query: 812 EAQSLVHFQLRHGNDLLA-MDAIQ---------GCDVNLKEQGQLVRQDEFVVRTGRHKS 861
+A ++ +H N + M+ +Q G + ++ + + ++ V++ ++
Sbjct: 275 KALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRN 334
Query: 862 ---VRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRR 918
R +FLF +LL+ PR G F + +A + + E + F F
Sbjct: 335 DPMERYLFLFNNMLLYCVPRVIQVGAQ-FQVRTRIDVAGMKVREL---MDAEFPHSFLVS 390
Query: 919 KARDTFVLQASS----LAIKQAWTADISHLLWRQAVHNK-------EVRMAEMVSMGVGN 967
+ T LQA S ++ QA+ A I + R +++ E+ S +G
Sbjct: 391 GKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGL 450
Query: 968 KAFRDIAPSEEAINDRTVNYVLKCRE 993
+A + + D+ V ++C+E
Sbjct: 451 RA-------PQWVRDKMVTMCMRCQE 469
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 59.7 bits (143), Expect = 1e-08
Identities = 74/292 (25%), Positives = 120/292 (41%), Gaps = 37/292 (12%)
Query: 631 LPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 690
L ++ P PP ++ ++ L E+ TE +Y L +++ L R PQ +
Sbjct: 177 LMRSEPVSMPPKMTE---YDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDI 233
Query: 691 RGQRAHLFGNLEKLRDFHCHFFLRELEAC-TRHPPRVAYAFLRHRVQFGMYALY------ 743
+F N+E L H HF EA T + F++++ +F +Y Y
Sbjct: 234 E----IIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289
Query: 744 -SKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGG 802
SK+ R A + Q+A L L+ P+QR+ KY LLLQEL +
Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVK---- 345
Query: 803 PTQE----------LSALREAQSLVHFQLRHGNDLLAMD-----AIQGCDVNLKEQGQLV 847
TQE L A+R+ V+ +++ N+ L +I+ D +L G+
Sbjct: 346 HTQEAMEKENLRLALDAMRDLAQCVN-EVKRDNETLRQITNFQLSIENLDQSLAHYGRPK 404
Query: 848 RQDEFVVRT--GRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMAD 897
E + + R K R FL ++ LL K R + F SF++ D
Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRD 456
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 35/193 (18%)
Query: 650 NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHC 709
++L+ V+ E++ TER YV+ L ME Y L + + + LFGNL ++ +F
Sbjct: 1039 DKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLT--QDELDVLFGNLTEMVEFQV 1096
Query: 710 HFFLRELEACTRHPP----------------RVAYAFLRHRVQFGMYALYSKNKPR-SDA 752
F L+ LE R P + +FL + +F +Y+ + + +
Sbjct: 1097 EF-LKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKV 1155
Query: 753 LMSSYGHTFFK---DKQQALGDHLD-LASYLLKPIQRMGKYALLLQELARACGGPTQELS 808
L+ + T FK D Q H L SYL+KPIQR+ KY LLL +EL
Sbjct: 1156 LVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL-----------RELF 1204
Query: 809 ALREAQSLVHFQL 821
AL +A+S H+ L
Sbjct: 1205 ALTDAESEEHYHL 1217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,276,640
Number of Sequences: 37866
Number of extensions: 2333437
Number of successful extensions: 9505
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 9164
Number of HSP's gapped (non-prelim): 352
length of query: 1110
length of database: 18,247,518
effective HSP length: 113
effective length of query: 997
effective length of database: 13,968,660
effective search space: 13926754020
effective search space used: 13926754020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.