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Search of human proteins with 190343004
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
(443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 971 0.0
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 514 e-146
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 514 e-146
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 514 e-146
gi|19743803 fibulin 5 precursor [Homo sapiens] 494 e-140
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 300 1e-81
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 300 1e-81
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 248 6e-66
gi|34734066 fibulin 1 isoform D [Homo sapiens] 243 3e-64
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 224 1e-58
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 224 1e-58
gi|194328809 latent transforming growth factor beta binding prot... 190 3e-48
gi|18497288 latent transforming growth factor beta binding prote... 190 3e-48
gi|66346695 fibrillin 2 precursor [Homo sapiens] 189 6e-48
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45
gi|110347437 latent transforming growth factor beta binding prot... 180 2e-45
gi|110347412 latent transforming growth factor beta binding prot... 180 2e-45
gi|110347431 latent transforming growth factor beta binding prot... 180 2e-45
gi|24430141 fibrillin 1 precursor [Homo sapiens] 177 2e-44
gi|56237021 fibrillin 3 precursor [Homo sapiens] 172 4e-43
gi|118572606 hemicentin 1 [Homo sapiens] 169 5e-42
gi|4557733 latent transforming growth factor beta binding protei... 162 4e-40
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 157 1e-38
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 157 1e-38
gi|46249414 latent transforming growth factor beta binding prote... 155 9e-38
gi|46249412 latent transforming growth factor beta binding prote... 155 9e-38
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 147 1e-35
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 145 7e-35
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 971 bits (2511), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT 60
MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
Sbjct: 1 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT 60
Query: 61 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS 120
IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS
Sbjct: 61 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS 120
Query: 121 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL 180
CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL
Sbjct: 121 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL 180
Query: 181 PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS 240
PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS
Sbjct: 181 PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS 240
Query: 241 CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC 300
CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC
Sbjct: 241 CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC 300
Query: 301 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADV 360
VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADV
Sbjct: 301 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADV 360
Query: 361 FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM 420
FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM
Sbjct: 361 FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM 420
Query: 421 NSLMSYRASSVLRLTVFVGAYTF 443
NSLMSYRASSVLRLTVFVGAYTF
Sbjct: 421 NSLMSYRASSVLRLTVFVGAYTF 443
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 514 bits (1325), Expect = e-146
Identities = 241/488 (49%), Positives = 313/488 (64%), Gaps = 62/488 (12%)
Query: 17 LLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYG 76
L +L L QD+EE +YT+CTDGYEWDP Q C+D++EC +P+ACKG MKC+NHYG
Sbjct: 7 LTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYG 66
Query: 77 GYLC------------------------------------------LPRSAAVINDLHGE 94
GYLC LP V +
Sbjct: 67 GYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
Query: 95 GPPP------------PVPPAQHP-NP-----CPPGYEPDDQDSCVDVDECAQALHDCRP 136
GP P P + P NP C GYE + + C D+DEC H+CR
Sbjct: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRA 186
Query: 137 SQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVNLPGSFRCQCEPGFQLG 195
Q C NL GS+ C CP GY+K G +CVDIDEC YC RCVN PGSF CQC PGFQL
Sbjct: 187 DQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLA 246
Query: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQ 255
NN +CVD+NECD C Q+C+N G+F+C+C+QGYEL D +C DIDEC SSYLCQ
Sbjct: 247 ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ 306
Query: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315
Y+CVNEPG+FSC CPQGYQ++ +R CQDI+ECE+ ++C E + C N+HGG+RC N C
Sbjct: 307 YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPC 365
Query: 316 VEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNA 375
+PYI ENRC+CP SN +CRE P SIV++YM+I S+RSVP+D+FQIQAT++Y N
Sbjct: 366 QDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINT 425
Query: 376 FQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLT 435
F+I++GN G+FY+RQ + VSAMLVL + ++GPRE+++DLEM+T++S+ ++R SSVLRLT
Sbjct: 426 FRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLT 485
Query: 436 VFVGAYTF 443
+ VG ++F
Sbjct: 486 IIVGPFSF 493
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 514 bits (1325), Expect = e-146
Identities = 241/488 (49%), Positives = 313/488 (64%), Gaps = 62/488 (12%)
Query: 17 LLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYG 76
L +L L QD+EE +YT+CTDGYEWDP Q C+D++EC +P+ACKG MKC+NHYG
Sbjct: 7 LTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYG 66
Query: 77 GYLC------------------------------------------LPRSAAVINDLHGE 94
GYLC LP V +
Sbjct: 67 GYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
Query: 95 GPPP------------PVPPAQHP-NP-----CPPGYEPDDQDSCVDVDECAQALHDCRP 136
GP P P + P NP C GYE + + C D+DEC H+CR
Sbjct: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRA 186
Query: 137 SQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVNLPGSFRCQCEPGFQLG 195
Q C NL GS+ C CP GY+K G +CVDIDEC YC RCVN PGSF CQC PGFQL
Sbjct: 187 DQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLA 246
Query: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQ 255
NN +CVD+NECD C Q+C+N G+F+C+C+QGYEL D +C DIDEC SSYLCQ
Sbjct: 247 ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ 306
Query: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315
Y+CVNEPG+FSC CPQGYQ++ +R CQDI+ECE+ ++C E + C N+HGG+RC N C
Sbjct: 307 YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPC 365
Query: 316 VEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNA 375
+PYI ENRC+CP SN +CRE P SIV++YM+I S+RSVP+D+FQIQAT++Y N
Sbjct: 366 QDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINT 425
Query: 376 FQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLT 435
F+I++GN G+FY+RQ + VSAMLVL + ++GPRE+++DLEM+T++S+ ++R SSVLRLT
Sbjct: 426 FRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLT 485
Query: 436 VFVGAYTF 443
+ VG ++F
Sbjct: 486 IIVGPFSF 493
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 514 bits (1325), Expect = e-146
Identities = 241/488 (49%), Positives = 313/488 (64%), Gaps = 62/488 (12%)
Query: 17 LLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYG 76
L +L L QD+EE +YT+CTDGYEWDP Q C+D++EC +P+ACKG MKC+NHYG
Sbjct: 7 LTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYG 66
Query: 77 GYLC------------------------------------------LPRSAAVINDLHGE 94
GYLC LP V +
Sbjct: 67 GYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
Query: 95 GPPP------------PVPPAQHP-NP-----CPPGYEPDDQDSCVDVDECAQALHDCRP 136
GP P P + P NP C GYE + + C D+DEC H+CR
Sbjct: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRA 186
Query: 137 SQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVNLPGSFRCQCEPGFQLG 195
Q C NL GS+ C CP GY+K G +CVDIDEC YC RCVN PGSF CQC PGFQL
Sbjct: 187 DQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLA 246
Query: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQ 255
NN +CVD+NECD C Q+C+N G+F+C+C+QGYEL D +C DIDEC SSYLCQ
Sbjct: 247 ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ 306
Query: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315
Y+CVNEPG+FSC CPQGYQ++ +R CQDI+ECE+ ++C E + C N+HGG+RC N C
Sbjct: 307 YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPC 365
Query: 316 VEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNA 375
+PYI ENRC+CP SN +CRE P SIV++YM+I S+RSVP+D+FQIQAT++Y N
Sbjct: 366 QDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINT 425
Query: 376 FQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLT 435
F+I++GN G+FY+RQ + VSAMLVL + ++GPRE+++DLEM+T++S+ ++R SSVLRLT
Sbjct: 426 FRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLT 485
Query: 436 VFVGAYTF 443
+ VG ++F
Sbjct: 486 IIVGPFSF 493
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 494 bits (1273), Expect = e-140
Identities = 226/453 (49%), Positives = 300/453 (66%), Gaps = 22/453 (4%)
Query: 8 LPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKG 67
+PG + + +L L SP +++ +CT+G++ D S C D++EC TIPEAC+G
Sbjct: 1 MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRG 55
Query: 68 EMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPPAQHPNP--------CPP 111
+M C+N GGYLC+PR+ V + GP P PP PN C
Sbjct: 56 DMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRF 115
Query: 112 GYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR 171
GY+ D+ + CVDVDECA H C P+Q C N G Y C+C DGY + +C+DIDECRY
Sbjct: 116 GYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG 175
Query: 172 YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQG 231
YCQ C N+PGS+ C C PGF L + RSC DVNEC PC Q C N+YG+F+CRC G
Sbjct: 176 YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPG 235
Query: 232 YELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRLCQDIDECESG 290
YEL DG CSD+DECS+S +LCQ+ CVN+PG + C CP GY LL R CQDI+ECE
Sbjct: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
Query: 291 AHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI 350
H C+ QTC N GG++C+D RC EPY+++S+NRC+CPA NP CR+QP +I++R M +
Sbjct: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDV 355
Query: 351 TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPRE 410
S RSVPAD+FQ+QAT+ YPGAY FQI++GN +FY+RQ +SA LV+ RP+ GPRE
Sbjct: 356 VSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRE 415
Query: 411 YVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF 443
LDLEM+T+N+++++R SSV+RL ++V Y F
Sbjct: 416 IQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF 448
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 300 bits (769), Expect = 1e-81
Identities = 154/390 (39%), Positives = 212/390 (54%), Gaps = 36/390 (9%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C DG+ DP+ +C D+NEC ++ E C+ CIN G Y C
Sbjct: 796 CMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTC------------------ 836
Query: 99 PVPPAQHPNPCPPGYEP-DDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
++P C GY DD CVDV+EC +H C Q CHNLPGSY+C C G+++
Sbjct: 837 ----QRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQR 892
Query: 158 --IGPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP 212
G C+D++EC R CQH C N GS+RC C GF L + + C DVNEC+
Sbjct: 893 DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECE-AQR 951
Query: 213 CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSS-YLCQYRCVNEPGRFSCHCP- 270
C Q C N YG++ C C QGY+L DG +C+DIDEC+ + LC +RC+N PG + C CP
Sbjct: 952 CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPE 1011
Query: 271 QGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLC 329
QGY + A R C+D+DEC G H CSEA+TC N G +RC+ C Y+QVS+ +C
Sbjct: 1012 QGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE-CPPNYVQVSKTKCER 1070
Query: 330 PASNPL--CREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDF 387
+ C+ P+ I H + + VPA +F+I + G A I GN +G F
Sbjct: 1071 TTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYF 1130
Query: 388 YIRQINNVSAMLVLARPVTGPREYVLDLEM 417
R++N + ++ L R V PR++ LD+EM
Sbjct: 1131 GTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1160
Score = 122 bits (306), Expect = 7e-28
Identities = 104/412 (25%), Positives = 145/412 (35%), Gaps = 120/412 (29%)
Query: 25 ASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK--CINHYGGYLCLP 82
+SP+ S + T C G +W D+ C ++ E T C+ + C+++ C+
Sbjct: 432 SSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCM- 490
Query: 83 RSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSC------VDVDECAQALHDCRP 136
A V+ GE C +D DSC D C L
Sbjct: 491 --AGVLGAKEGE-------------TCGA----EDNDSCGISLYKQCCDCCGLGLRVRAE 531
Query: 137 SQDCHNLPG-SYQC-----TCPDGYRKI------------------------GPECV--- 163
Q C + P Y C +C +G + G E +
Sbjct: 532 GQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLG 591
Query: 164 ------------DIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSC------- 201
D DEC CQH C+N GS+ C C PGF L + R+C
Sbjct: 592 TEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPP 651
Query: 202 --------------------------VDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELH 235
N C PC+Q C G+ +C C GY +
Sbjct: 652 QPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM 711
Query: 236 RDGFSCSDIDECSYSSYLCQ--YRCVNEPGRFSCH----CPQGYQLLATRLCQDIDECES 289
DG SC DI+EC + C CVN G F C+ C GY L C+D+DEC
Sbjct: 712 ADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE-CEDVDECAM 770
Query: 290 GAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL----CPASNPLCR 337
G H C C N G + C RC++ ++Q E C+ C + + CR
Sbjct: 771 GTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCR 822
Score = 107 bits (267), Expect = 2e-23
Identities = 80/237 (33%), Positives = 104/237 (43%), Gaps = 52/237 (21%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIP-EACKGEMKCINHYGGYLCLPRSAAVIND 90
P SY +C G++ D + C DVNEC P C + C N G Y C
Sbjct: 879 PGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC--QHTCENTLGSYRC---------- 926
Query: 91 LHGEGPPPPVPPAQHPNPCPPGY-EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC 149
C G+ D C DV+EC R SQ+C N+ GSYQC
Sbjct: 927 -----------------SCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQC 965
Query: 150 TCPDGYR--KIGPECVDIDECRYR---YCQHRCVNLPGSFRCQC-EPGFQLGPNNRSCVD 203
C GY+ + G C DIDEC C RC+N+PGS++C C E G+ + N RSC D
Sbjct: 966 YCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1025
Query: 204 VNECDMGA-PCE--QRCFNSYGTFLC---RCHQGY----ELHRDGFSCSDIDECSYS 250
V+EC +G C + C N G+F C C Y + + +C D EC S
Sbjct: 1026 VDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1082
Score = 98.2 bits (243), Expect = 1e-20
Identities = 84/277 (30%), Positives = 112/277 (40%), Gaps = 51/277 (18%)
Query: 47 PDSQHCRDVNECLTIP-EACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQH 105
P+S D +ECL +P E C + CIN G Y C + D G P P Q
Sbjct: 597 PNSLPGDDQDECLLLPGELC--QHLCINTVGSYHCACFPGFSLQD-DGRTCRPEGHPPQP 653
Query: 106 PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDI 165
P P + E +Q + P LP TC D GP
Sbjct: 654 EAPQEPALK----------SEFSQVASNTIP------LPLPQPNTCKDN----GP----- 688
Query: 166 DECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYG 222
C+ C + GS C C PG+ + + SC D+NEC C + C N+ G
Sbjct: 689 -------CKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLG 741
Query: 223 TFLC----RCHQGYELHRDGFSCSDIDECSYSSYLCQ--YRCVNEPGRFSC----HCPQG 272
+F C C GY L +DG C D+DEC+ ++ CQ + C N G F C C G
Sbjct: 742 SFHCYKALTCEPGYAL-KDG-ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDG 799
Query: 273 YQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
+ C DI+EC S + C +C+N G Y C
Sbjct: 800 FLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTC 836
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 300 bits (769), Expect = 1e-81
Identities = 154/390 (39%), Positives = 212/390 (54%), Gaps = 36/390 (9%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C DG+ DP+ +C D+NEC ++ E C+ CIN G Y C
Sbjct: 843 CMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTC------------------ 883
Query: 99 PVPPAQHPNPCPPGYEP-DDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
++P C GY DD CVDV+EC +H C Q CHNLPGSY+C C G+++
Sbjct: 884 ----QRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQR 939
Query: 158 --IGPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP 212
G C+D++EC R CQH C N GS+RC C GF L + + C DVNEC+
Sbjct: 940 DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECE-AQR 998
Query: 213 CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSS-YLCQYRCVNEPGRFSCHCP- 270
C Q C N YG++ C C QGY+L DG +C+DIDEC+ + LC +RC+N PG + C CP
Sbjct: 999 CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPE 1058
Query: 271 QGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLC 329
QGY + A R C+D+DEC G H CSEA+TC N G +RC+ C Y+QVS+ +C
Sbjct: 1059 QGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE-CPPNYVQVSKTKCER 1117
Query: 330 PASNPL--CREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDF 387
+ C+ P+ I H + + VPA +F+I + G A I GN +G F
Sbjct: 1118 TTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYF 1177
Query: 388 YIRQINNVSAMLVLARPVTGPREYVLDLEM 417
R++N + ++ L R V PR++ LD+EM
Sbjct: 1178 GTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1207
Score = 119 bits (298), Expect = 6e-27
Identities = 104/399 (26%), Positives = 140/399 (35%), Gaps = 117/399 (29%)
Query: 25 ASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK--CINHYGGYLCLP 82
+SP+ S + T C G +W D+ C ++ E T C+ + C+++ C+
Sbjct: 432 SSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCM- 490
Query: 83 RSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSC------VDVDECAQALHDCRP 136
A V+ GE C +D DSC D C L
Sbjct: 491 --AGVLGAKEGE-------------TC----GAEDNDSCGISLYKQCCDCCGLGLRVRAE 531
Query: 137 SQDCHNLPG-SYQC-----TCPDGYRKI------------------------GPECV--- 163
Q C + P Y C +C +G + G E +
Sbjct: 532 GQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLG 591
Query: 164 ------------DIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSC------- 201
D DEC CQH C+N GS+ C C PGF L + R+C
Sbjct: 592 TEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPP 651
Query: 202 --------------------------VDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELH 235
N C PC+Q C G+ +C C GY +
Sbjct: 652 QPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM 711
Query: 236 RDGFSCSDIDECSYSSYLCQYR--CVNEPGRFSC-----HCPQGYQLLATRLCQDIDECE 288
DG SC D DEC ++ C R CVN G F C C GY L A R C DI+EC
Sbjct: 712 ADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECV 771
Query: 289 SGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRC 327
+ H CS + CVN G + C C EP + + C
Sbjct: 772 TDLHTCSRGEHCVNTLGSFHCYKALTC-EPGYALKDGEC 809
Score = 113 bits (282), Expect = 4e-25
Identities = 97/312 (31%), Positives = 127/312 (40%), Gaps = 60/312 (19%)
Query: 47 PDSQHCRDVNECLTIP-EACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQH 105
P+S D +ECL +P E C + CIN G Y C + D G P P Q
Sbjct: 597 PNSLPGDDQDECLLLPGELC--QHLCINTVGSYHCACFPGFSLQD-DGRTCRPEGHPPQP 653
Query: 106 PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDI 165
P P + E +Q + P LP TC D GP
Sbjct: 654 EAPQEPALK----------SEFSQVASNTIP------LPLPQPNTCKDN----GP----- 688
Query: 166 DECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCEQR--CFNSYG 222
C+ C + GS C C PG+ + + SC D +EC MGA C +R C N+ G
Sbjct: 689 -------CKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLG 741
Query: 223 TFLC-----RCHQGYEL--HRDGFSCSDIDECSYSSYLCQY--RCVNEPGRFSCH----C 269
+F C C GY L HR C DI+EC + C CVN G F C+ C
Sbjct: 742 SFYCVNHTVLCADGYILNAHR---KCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTC 798
Query: 270 PQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL- 328
GY L C+D+DEC G H C C N G + C RC++ ++Q E C+
Sbjct: 799 EPGYALKDGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVD 857
Query: 329 ---CPASNPLCR 337
C + + CR
Sbjct: 858 INECTSLSEPCR 869
Score = 107 bits (267), Expect = 2e-23
Identities = 80/237 (33%), Positives = 104/237 (43%), Gaps = 52/237 (21%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIP-EACKGEMKCINHYGGYLCLPRSAAVIND 90
P SY +C G++ D + C DVNEC P C + C N G Y C
Sbjct: 926 PGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC--QHTCENTLGSYRC---------- 973
Query: 91 LHGEGPPPPVPPAQHPNPCPPGY-EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC 149
C G+ D C DV+EC R SQ+C N+ GSYQC
Sbjct: 974 -----------------SCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQC 1012
Query: 150 TCPDGYR--KIGPECVDIDECRYR---YCQHRCVNLPGSFRCQC-EPGFQLGPNNRSCVD 203
C GY+ + G C DIDEC C RC+N+PGS++C C E G+ + N RSC D
Sbjct: 1013 YCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1072
Query: 204 VNECDMGA-PCE--QRCFNSYGTFLC---RCHQGY----ELHRDGFSCSDIDECSYS 250
V+EC +G C + C N G+F C C Y + + +C D EC S
Sbjct: 1073 VDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1129
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 248 bits (634), Expect = 6e-66
Identities = 160/508 (31%), Positives = 222/508 (43%), Gaps = 133/508 (26%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY+ D C DVNEC+T +C+ CIN G + C
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------------------ 242
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT-------- 150
Q + C GYE + +SC D+DEC +H+C P C N GS++C
Sbjct: 243 -----QRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Query: 151 ---------------------CPDGYRKI------------------------GPECVDI 165
CP G+ I G CVD+
Sbjct: 298 FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
Query: 166 DECR--YRYCQ--HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD------------- 208
DEC C HRCVN PGSFRC+C+ G+ +R CVDVNEC
Sbjct: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Query: 209 ----------------------------MGAPCEQRCFNSYGTFLCRCHQGYELHR-DGF 239
+PC Q C N YG++ C C +GY+L DG
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGV 477
Query: 240 SCSDIDECSY--SSYLCQYRCVNEPGRFSCHCP-QGYQLLAT-RLCQDIDECESGAHQCS 295
+C DIDEC+ ++C YRC+N PG F C CP GY+L R CQDIDEC +G H CS
Sbjct: 478 TCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCS 537
Query: 296 EAQTCVNFHGGYRCVDTNRCVEPYIQVSENRC--LCPASNPLCREQPSSIVHRYMTITSE 353
+TC N GG+RC+ C E Y + + RC L N C + P I + +++ +
Sbjct: 538 INETCFNIQGGFRCL-AFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTN 596
Query: 354 RSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVL 413
PA VF++ +S PG I GN +G F R+++ S ++ L +PV PR+ +L
Sbjct: 597 IQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLL 656
Query: 414 DLEM-VTMNSLMSYRASSVLRLTVFVGA 440
++M ++ + +S S V +L +FV A
Sbjct: 657 TVKMDLSRHGTVS---SFVAKLFIFVSA 681
Score = 103 bits (257), Expect = 3e-22
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262
+ C G PC+Q+C ++ +C C GY+L DG SC D++EC S+ C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
G F C C GY+L C+DIDECESG H C C N G +RC +C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Query: 319 YIQVSENRCL 328
+IQ + C+
Sbjct: 298 FIQDALGNCI 307
Score = 93.2 bits (230), Expect = 4e-19
Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)
Query: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227
C+ +C + C C G+QL + SC DVNEC G+ C + C N+ G+F C+
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279
C GYEL D SC DIDEC + C + C N G F C C G+ A
Sbjct: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318
C DI+EC S + C TC+N G Y RCVD + C P
Sbjct: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 243 bits (620), Expect = 3e-64
Identities = 160/438 (36%), Positives = 224/438 (51%), Gaps = 59/438 (13%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C G+ D +C D+NECL+I C CIN G Y C
Sbjct: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV------------- 338
Query: 98 PPVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
PN C GY +++ + CVDVDECA C C N PGS++C C GY
Sbjct: 339 --------PN-CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
Query: 157 --KIGPECVDIDEC-RY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
I CVD++EC RY R C H+C N GS+ C C GF+L + RSC D+NEC +
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448
Query: 212 PCEQRCFNSYGTFLCRCHQGYELHR-DGFSCSDIDECSYSS--YLCQYRCVNEPGRFSCH 268
PC Q C N YG++ C C +GY+L DG +C DIDEC+ + ++C YRC+N PG F C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCS 508
Query: 269 CPQ-GYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN- 325
CP GY+L R CQDIDEC +G H CS +TC N GG+RC+ C E Y + +
Sbjct: 509 CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL-AFECPENYRRSAATL 567
Query: 326 --------RCL--CPASNPLCREQP-SSIVHRYMTITSERSV--PADVFQIQA-TSVYPG 371
RC+ C ++ C P +I H +++ + R P ++ ++A T +P
Sbjct: 568 QQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPA 627
Query: 372 --AYNAFQIRAGNSQGDFYI--RQINNVSAMLV-LARPVTGPREYVLDLEM-VTMNSLMS 425
A F I GN + F I R ++ ++ +V RP+ GP VL LEM + ++S
Sbjct: 628 SQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVS 687
Query: 426 YRASSVLRLTVFVGAYTF 443
+R +V+ + +FV Y F
Sbjct: 688 HR--NVVNVHIFVSEYWF 703
Score = 103 bits (257), Expect = 3e-22
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262
+ C G PC+Q+C ++ +C C GY+L DG SC D++EC S+ C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
G F C C GY+L C+DIDECESG H C C N G +RC +C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Query: 319 YIQVSENRCL 328
+IQ + C+
Sbjct: 298 FIQDALGNCI 307
Score = 93.2 bits (230), Expect = 4e-19
Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)
Query: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227
C+ +C + C C G+QL + SC DVNEC G+ C + C N+ G+F C+
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279
C GYEL D SC DIDEC + C + C N G F C C G+ A
Sbjct: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318
C DI+EC S + C TC+N G Y RCVD + C P
Sbjct: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 224 bits (571), Expect = 1e-58
Identities = 123/293 (41%), Positives = 157/293 (53%), Gaps = 36/293 (12%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C G+ D +C D+NECL+I C CIN G Y C
Sbjct: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV------------- 338
Query: 98 PPVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
PN C GY +++ + CVDVDECA C C N PGS++C C GY
Sbjct: 339 --------PN-CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
Query: 157 --KIGPECVDIDEC-RY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
I CVD++EC RY R C H+C N GS+ C C GF+L + RSC D+NEC +
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448
Query: 212 PCEQRCFNSYGTFLCRCHQGYELHR-DGFSCSDIDECSYSS--YLCQYRCVNEPGRFSCH 268
PC Q C N YG++ C C +GY+L DG +C DIDEC+ + ++C YRC+N PG F C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCS 508
Query: 269 CPQ-GYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY 319
CP GY+L R CQDIDEC +G H CS +TC N GG+RC+ C E Y
Sbjct: 509 CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL-AFECPENY 560
Score = 103 bits (257), Expect = 3e-22
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262
+ C G PC+Q+C ++ +C C GY+L DG SC D++EC S+ C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
G F C C GY+L C+DIDECESG H C C N G +RC +C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Query: 319 YIQVSENRCL 328
+IQ + C+
Sbjct: 298 FIQDALGNCI 307
Score = 93.2 bits (230), Expect = 4e-19
Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)
Query: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227
C+ +C + C C G+QL + SC DVNEC G+ C + C N+ G+F C+
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279
C GYEL D SC DIDEC + C + C N G F C C G+ A
Sbjct: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318
C DI+EC S + C TC+N G Y RCVD + C P
Sbjct: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 224 bits (571), Expect = 1e-58
Identities = 123/293 (41%), Positives = 157/293 (53%), Gaps = 36/293 (12%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C G+ D +C D+NECL+I C CIN G Y C
Sbjct: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV------------- 338
Query: 98 PPVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
PN C GY +++ + CVDVDECA C C N PGS++C C GY
Sbjct: 339 --------PN-CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
Query: 157 --KIGPECVDIDEC-RY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
I CVD++EC RY R C H+C N GS+ C C GF+L + RSC D+NEC +
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448
Query: 212 PCEQRCFNSYGTFLCRCHQGYELHR-DGFSCSDIDECSYSS--YLCQYRCVNEPGRFSCH 268
PC Q C N YG++ C C +GY+L DG +C DIDEC+ + ++C YRC+N PG F C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCS 508
Query: 269 CPQ-GYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY 319
CP GY+L R CQDIDEC +G H CS +TC N GG+RC+ C E Y
Sbjct: 509 CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL-AFECPENY 560
Score = 103 bits (257), Expect = 3e-22
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262
+ C G PC+Q+C ++ +C C GY+L DG SC D++EC S+ C+ C+N
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
G F C C GY+L C+DIDECESG H C C N G +RC +C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Query: 319 YIQVSENRCL 328
+IQ + C+
Sbjct: 298 FIQDALGNCI 307
Score = 93.2 bits (230), Expect = 4e-19
Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)
Query: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227
C+ +C + C C G+QL + SC DVNEC G+ C + C N+ G+F C+
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279
C GYEL D SC DIDEC + C + C N G F C C G+ A
Sbjct: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318
C DI+EC S + C TC+N G Y RCVD + C P
Sbjct: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 190 bits (482), Expect = 3e-48
Identities = 115/302 (38%), Positives = 144/302 (47%), Gaps = 27/302 (8%)
Query: 33 PDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------- 81
PD C GY P ++C DVNEC P G C+N G Y C
Sbjct: 595 PDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNCHCNRGYRLHVGA 653
Query: 82 -PRSAAVIND-----LHGEGPPPPVPPAQHPNPCPPGY--EPDDQDSCVDVDECAQALHD 133
RS +N+ L G+G P + C PGY + C D+DEC
Sbjct: 654 GGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDP-SS 712
Query: 134 CRPSQDCHNLPGSYQC-TCPDGYRKIGP-ECVDIDECRYRY-CQHR-CVNLPGSFRCQCE 189
C P C N PGS++C C GYR G C D++EC C C NLPGSFRC C
Sbjct: 713 C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA 771
Query: 190 PGFQLGPNNRSCVDVNECDMGAPCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECS 248
G+ P+ RSC+DV+EC+ G C+ C N+ G+F C+C GY L RD C DIDEC
Sbjct: 772 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD 831
Query: 249 YSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308
+ + C+N G + C CPQG++L+ R CQDIDEC C C N G Y
Sbjct: 832 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
Query: 309 CV 310
CV
Sbjct: 892 CV 893
Score = 132 bits (331), Expect = 8e-31
Identities = 87/271 (32%), Positives = 123/271 (45%), Gaps = 46/271 (16%)
Query: 91 LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-----DSCVDVDECAQALHDCRPSQDCHNLPG 145
LH +GPP P + P+ PP + +++ DS V + Q H + P
Sbjct: 482 LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
Query: 146 SYQCTCPDGYR-------------KIGP-ECVDIDECRYRY--CQH-RCVNLPGSFRCQC 188
P R +I P + + DECR C H CV P + C C
Sbjct: 542 LISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHC 601
Query: 189 EPGFQLGPNNRSCVDVNECDMGAPC---EQRCFNSYGTFLCRCHQGYELH--RDGFSCSD 243
PG++ P +R CVDVNEC+ PC C N+ G++ C C++GY LH G SC D
Sbjct: 602 NPGYRSHPQHRYCVDVNECE-AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
Query: 244 IDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQLLATR--LCQDIDEC------------ 287
++EC+ +LC C+N PG + C+C GY+L A+R +C+DIDEC
Sbjct: 661 LNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
Query: 288 -ESGAHQCSEAQTCVNFHGGYRCVDTNRCVE 317
+ G+ +C Q GG C D N C E
Sbjct: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAE 750
Score = 109 bits (272), Expect = 6e-24
Identities = 97/361 (26%), Positives = 131/361 (36%), Gaps = 93/361 (25%)
Query: 30 SEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVI 88
S P S+ +C GY D HC D++EC P AC G CIN G Y CL
Sbjct: 801 SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRCL------- 851
Query: 89 NDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148
CP G+ C D+DEC+Q C P C NL GSY
Sbjct: 852 --------------------CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
Query: 149 CTCPDGYRKIGPE--CVDIDECRYR-----------YC----------QHRCVNLPGSFR 185
C C +G+ + C ++++ ++ +C Q C +L +
Sbjct: 892 CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG 951
Query: 186 CQCE----PGFQLGPNNRSC-------VDVNECDMGAPC----------------EQRCF 218
CE P + + C D N + G P E +C
Sbjct: 952 DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV 1011
Query: 219 NSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHC-PQGYQLLA 277
N+ + C C QG+ + C D+DEC S C N G + C C P A
Sbjct: 1012 NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA 1071
Query: 278 TRLC-----QDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR-CLCPA 331
R C D+DEC+ A C + CVN G YRC C P++ R C P
Sbjct: 1072 QRQCLSPEEMDVDECQDPA-ACRPGR-CVNLPGSYRC----ECRPPWVPGPSGRDCQLPE 1125
Query: 332 S 332
S
Sbjct: 1126 S 1126
Score = 95.5 bits (236), Expect = 9e-20
Identities = 101/351 (28%), Positives = 130/351 (37%), Gaps = 117/351 (33%)
Query: 39 CTDGYEWDPDSQHC-------RDVNECLTI-PEACKGEMKCINHYGGYLCLPRSAAVIND 90
C DG + D+ RD++EC+ E CK E KC+N GY C
Sbjct: 971 CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK-EGKCVNTQPGYECY--------- 1020
Query: 91 LHGEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQC 149
C G+ D CVDVDEC +CR C N G Y+C
Sbjct: 1021 ------------------CKQGFYYDGNLLECVDVDECLDE-SNCRNGV-CENTRGGYRC 1060
Query: 150 TC-------PDGYRKIGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEP---------- 190
C P + + PE +D+DEC+ C+ RCVNLPGS+RC+C P
Sbjct: 1061 ACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRD 1120
Query: 191 -------------------------GFQLGPNNRSCVDVNEC------DMGA---PCEQR 216
G GP + ++C GA PC R
Sbjct: 1121 CQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPR 1180
Query: 217 CFNSYGTFLCRCHQ--------------GYELHRDGFSCSDIDECSYSSYLCQYRCVNEP 262
S+ C Q G + S D DEC S RCV P
Sbjct: 1181 GAGSH----CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG----RCVPRP 1232
Query: 263 GRFSCHCPQGYQLLATRL-CQDIDECESGAHQ--CSEAQTCVNFHGGYRCV 310
G C CP G+QL A+R C DIDEC + +++ CVN G +RCV
Sbjct: 1233 GGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1283
Score = 71.6 bits (174), Expect = 1e-12
Identities = 79/308 (25%), Positives = 102/308 (33%), Gaps = 99/308 (32%)
Query: 32 EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
+P C G+ +D + C DV+ECL G C N GGY C
Sbjct: 1014 QPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV--CENTRGGYRCACT-------- 1063
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
PP PAQ P +DVDEC Q CRP + C NLPGSY+C C
Sbjct: 1064 ----PPAEYSPAQRQCLSPEE---------MDVDEC-QDPAACRPGR-CVNLPGSYRCEC 1108
Query: 152 ---------------PDGYRKIGPECVDI----------------------DECRYRYCQ 174
P+ + PE D+ D+C
Sbjct: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDC------ 1162
Query: 175 HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD---------MGAPCEQ---------- 215
C + QC P G + +E + +G P
Sbjct: 1163 --CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220
Query: 216 ------RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLCQ-YRCVNEPGRF 265
RC G +C C G++L C DIDEC + LC+ RCVN G F
Sbjct: 1221 CRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280
Query: 266 SCHCPQGY 273
C C G+
Sbjct: 1281 RCVCKAGF 1288
Score = 65.1 bits (157), Expect = 1e-10
Identities = 67/248 (27%), Positives = 94/248 (37%), Gaps = 57/248 (22%)
Query: 39 CTDGYEWDPDSQHC-----RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93
CT E+ P + C DV+EC P AC+ +C+N G Y C R V
Sbjct: 1062 CTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPG-RCVNLPGSYRCECRPPWVPGPSGR 1119
Query: 94 EGPPPPVPPAQHPNPCPPGYEPDDQDS---------CVDVDECAQALHDCRPSQ----DC 140
+ P P + P + +D + D+C CR + C
Sbjct: 1120 DCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCC-----CRQGRGWGAQC 1174
Query: 141 HNLP----GSYQCTCP------DGYRKIGPECV------------DIDECRYRYCQHRCV 178
P GS+ CP + + P + D DECR RCV
Sbjct: 1175 RPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC--VSGRCV 1229
Query: 179 NLPGSFRCQCEPGFQLGPNNRSCVDVNEC----DMGAPCE-QRCFNSYGTFLCRCHQGYE 233
PG C+C GFQL + CVD++EC G C+ +RC N+ G+F C C G+
Sbjct: 1230 PRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFA 1289
Query: 234 LHRDGFSC 241
R +C
Sbjct: 1290 RSRPHGAC 1297
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/135 (28%), Positives = 52/135 (38%), Gaps = 32/135 (23%)
Query: 96 PPPPVPPAQHP-----------NPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLP 144
P P PP Q P PC P ++C ++ CH P
Sbjct: 265 PSHPRPPTQKPLGRCFQDTLPKQPCGSNPLP----GLTKQEDCCGSIGTAWGQSKCHKCP 320
Query: 145 --------------GSYQCTCPDGYRKIGP-ECVDIDECRYR-YCQHR-CVNLPGSFRCQ 187
G CP GY+++ C DI+EC C+H C+N PGS+RC
Sbjct: 321 QLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCV 380
Query: 188 CEPGFQLGPNNRSCV 202
C PG LGP+ C+
Sbjct: 381 CPPGHSLGPSRTQCI 395
Score = 46.2 bits (108), Expect = 6e-05
Identities = 56/206 (27%), Positives = 76/206 (36%), Gaps = 24/206 (11%)
Query: 102 PAQH--PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIG 159
P+QH P+P P P Q + C Q D P Q C + P D IG
Sbjct: 255 PSQHLLPHPKPSHPRPPTQKP---LGRCFQ---DTLPKQPCGSNPLPGLTKQEDCCGSIG 308
Query: 160 PECVDIDECRYRYCQHRCVNLPGSFR----CQCEPGFQLGPNNRSCVDVNECDMGAPCEQ 215
+ Q+ V PG R C G++ N+ C D+NEC M C
Sbjct: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKR-LNSTHCQDINECAMPGVCRH 367
Query: 216 -RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274
C N+ G++ C C G+ L C I + LC +R V+ C P
Sbjct: 368 GDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLC-FRLVSP--EHQCQHP---- 418
Query: 275 LLATRLCQDIDECESGAHQCSEAQTC 300
L TRL + + C G + Q C
Sbjct: 419 -LTTRLTRQLCCCSVGKAWGARCQRC 443
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/84 (35%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 255 QYRCVNEPG----RFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
QY V +PG CPQGY+ L + CQDI+EC C C+N G YRCV
Sbjct: 323 QYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV 380
Query: 311 DTNRCVEPYIQVSENRCLCPASNP 334
P + +R C A P
Sbjct: 381 -----CPPGHSLGPSRTQCIADKP 399
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 22/115 (19%)
Query: 4 CASCLPGSLLLWALLLLLLGSAS-PQDSEEPDS-----------------YTECTDGYEW 45
C + S W LLLG +DS E DS EC G++
Sbjct: 1186 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1245
Query: 46 DPDSQHCRDVNECLTIPE---ACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
D C D++EC + + CK E +C+N G + C+ ++ + HG P
Sbjct: 1246 DASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKAGFARSRPHGACVP 1299
Score = 36.6 bits (83), Expect = 0.047
Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 3/44 (6%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL 81
+C GY+ +S HC+D+NEC +P C+ C+N+ G Y C+
Sbjct: 340 DCPQGYK-RLNSTHCQDINEC-AMPGVCR-HGDCLNNPGSYRCV 380
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 190 bits (482), Expect = 3e-48
Identities = 115/302 (38%), Positives = 144/302 (47%), Gaps = 27/302 (8%)
Query: 33 PDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------- 81
PD C GY P ++C DVNEC P G C+N G Y C
Sbjct: 595 PDYSCHCNPGYRSHPQHRYCVDVNECEAEP-CGPGRGICMNTGGSYNCHCNRGYRLHVGA 653
Query: 82 -PRSAAVIND-----LHGEGPPPPVPPAQHPNPCPPGY--EPDDQDSCVDVDECAQALHD 133
RS +N+ L G+G P + C PGY + C D+DEC
Sbjct: 654 GGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDP-SS 712
Query: 134 CRPSQDCHNLPGSYQC-TCPDGYRKIGP-ECVDIDECRYRY-CQHR-CVNLPGSFRCQCE 189
C P C N PGS++C C GYR G C D++EC C C NLPGSFRC C
Sbjct: 713 C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA 771
Query: 190 PGFQLGPNNRSCVDVNECDMGAPCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECS 248
G+ P+ RSC+DV+EC+ G C+ C N+ G+F C+C GY L RD C DIDEC
Sbjct: 772 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD 831
Query: 249 YSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308
+ + C+N G + C CPQG++L+ R CQDIDEC C C N G Y
Sbjct: 832 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
Query: 309 CV 310
CV
Sbjct: 892 CV 893
Score = 132 bits (331), Expect = 8e-31
Identities = 87/271 (32%), Positives = 123/271 (45%), Gaps = 46/271 (16%)
Query: 91 LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-----DSCVDVDECAQALHDCRPSQDCHNLPG 145
LH +GPP P + P+ PP + +++ DS V + Q H + P
Sbjct: 482 LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541
Query: 146 SYQCTCPDGYR-------------KIGP-ECVDIDECRYRY--CQH-RCVNLPGSFRCQC 188
P R +I P + + DECR C H CV P + C C
Sbjct: 542 LISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHC 601
Query: 189 EPGFQLGPNNRSCVDVNECDMGAPC---EQRCFNSYGTFLCRCHQGYELH--RDGFSCSD 243
PG++ P +R CVDVNEC+ PC C N+ G++ C C++GY LH G SC D
Sbjct: 602 NPGYRSHPQHRYCVDVNECE-AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD 660
Query: 244 IDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQLLATR--LCQDIDEC------------ 287
++EC+ +LC C+N PG + C+C GY+L A+R +C+DIDEC
Sbjct: 661 LNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCE 719
Query: 288 -ESGAHQCSEAQTCVNFHGGYRCVDTNRCVE 317
+ G+ +C Q GG C D N C E
Sbjct: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAE 750
Score = 106 bits (265), Expect = 4e-23
Identities = 90/324 (27%), Positives = 129/324 (39%), Gaps = 69/324 (21%)
Query: 30 SEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVI 88
S P S+ +C GY D HC D++EC P AC G CIN G Y CL
Sbjct: 801 SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGG-DCINTNGSYRCL------- 851
Query: 89 NDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148
CP G+ C D+DEC+Q C P C NL GSY
Sbjct: 852 --------------------CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891
Query: 149 CTCPDGYRKIGPE--CVDIDECRYR-----------YCQHRCVNLPGSFRCQCEPGFQLG 195
C C +G+ + C ++++ ++ +C C C G G
Sbjct: 892 CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG 951
Query: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCS-----DIDECS-Y 249
+ ++ C + + E F+S LC +GY + + DIDEC +
Sbjct: 952 DH----CEIYPCPVYSSAE---FHS----LCPDGKGYTQDNNIVNYGIPAHRDIDECMLF 1000
Query: 250 SSYLC-QYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGY 307
S +C + +CVN + C+C QG+ L C D+DEC ++ C C N GGY
Sbjct: 1001 GSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNG-VCENTRGGY 1058
Query: 308 RCVDTNRCVEP-YIQVSENRCLCP 330
RC C P ++ +CL P
Sbjct: 1059 RCA----CTPPAEYSPAQRQCLSP 1078
Score = 84.7 bits (208), Expect = 2e-16
Identities = 78/283 (27%), Positives = 104/283 (36%), Gaps = 72/283 (25%)
Query: 96 PPPPVPPAQHPNPCPPGYEPDDQDSCV--------DVDECAQALHDCRPSQDCHNLPGSY 147
P P A+ + CP G ++ V D+DEC + C N Y
Sbjct: 958 PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017
Query: 148 QCTCPDGYRKIGP--ECVDIDECRYRY-CQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVD 203
+C C G+ G ECVD+DEC C++ C N G +RC C P + P R C+
Sbjct: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077
Query: 204 VNECDMGAPCEQRCFNSYG--------------TF-LCRCHQG----------------- 231
E + C++ G TF C C QG
Sbjct: 1078 PEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS 1137
Query: 232 ----YELHRDGF-----------------SCSDIDECSYSSYLCQYRCVNEPGRFSCHCP 270
+ + F S D DEC S RCV PG C CP
Sbjct: 1138 HCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVS----GRCVPRPGGAVCECP 1193
Query: 271 QGYQLLATRL-CQDIDECESGAHQ--CSEAQTCVNFHGGYRCV 310
G+QL A+R C DIDEC + +++ CVN G +RCV
Sbjct: 1194 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236
Score = 69.7 bits (169), Expect = 5e-12
Identities = 73/255 (28%), Positives = 91/255 (35%), Gaps = 63/255 (24%)
Query: 32 EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
+P C G+ +D + C DV+ECL G C N GGY C
Sbjct: 1014 QPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV--CENTRGGYRCACT-------- 1063
Query: 92 HGEGPPPPVPPAQHPNPCPPGYE--PDDQDSCV----DVDECAQALHD-CRPSQDCHNLP 144
PP PAQ P E P+ +D C + CA L DC
Sbjct: 1064 ----PPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
Query: 145 G---SYQCT-CPDGYRKIGPECV-----------------------------DIDECRYR 171
G QC CP R G C D DECR
Sbjct: 1120 GRGWGAQCRPCPP--RGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC- 1176
Query: 172 YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC----DMGAPCE-QRCFNSYGTFLC 226
RCV PG C+C GFQL + CVD++EC G C+ +RC N+ G+F C
Sbjct: 1177 -VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1235
Query: 227 RCHQGYELHRDGFSC 241
C G+ R +C
Sbjct: 1236 VCKAGFARSRPHGAC 1250
Score = 61.6 bits (148), Expect = 1e-09
Identities = 77/302 (25%), Positives = 99/302 (32%), Gaps = 98/302 (32%)
Query: 39 CTDGYEWDPDSQHC-------RDVNECLTI-PEACKGEMKCINHYGGYLCLPRSAAVIND 90
C DG + D+ RD++EC+ E CK E KC+N GY C
Sbjct: 971 CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICK-EGKCVNTQPGYECY--------- 1020
Query: 91 LHGEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQC 149
C G+ D CVDVDEC +CR C N G Y+C
Sbjct: 1021 ------------------CKQGFYYDGNLLECVDVDECLDE-SNCRNGV-CENTRGGYRC 1060
Query: 150 TC--PDGYRKIGPECVDIDECRYRYCQHR--CVNLPGSFR---------------CQCEP 190
C P Y +C+ +E R + R C + G C C
Sbjct: 1061 ACTPPAEYSPAQRQCLSPEEME-RAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1119
Query: 191 GFQLGPNNRSCV-------------------DVNECDMGAPCEQ---------------- 215
G G R C D + +G P
Sbjct: 1120 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG 1179
Query: 216 RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLCQ-YRCVNEPGRFSCHCPQ 271
RC G +C C G++L C DIDEC + LC+ RCVN G F C C
Sbjct: 1180 RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKA 1239
Query: 272 GY 273
G+
Sbjct: 1240 GF 1241
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/135 (28%), Positives = 52/135 (38%), Gaps = 32/135 (23%)
Query: 96 PPPPVPPAQHP-----------NPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLP 144
P P PP Q P PC P ++C ++ CH P
Sbjct: 265 PSHPRPPTQKPLGRCFQDTLPKQPCGSNPLP----GLTKQEDCCGSIGTAWGQSKCHKCP 320
Query: 145 --------------GSYQCTCPDGYRKIGP-ECVDIDECRYR-YCQHR-CVNLPGSFRCQ 187
G CP GY+++ C DI+EC C+H C+N PGS+RC
Sbjct: 321 QLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCV 380
Query: 188 CEPGFQLGPNNRSCV 202
C PG LGP+ C+
Sbjct: 381 CPPGHSLGPSRTQCI 395
Score = 46.2 bits (108), Expect = 6e-05
Identities = 56/206 (27%), Positives = 76/206 (36%), Gaps = 24/206 (11%)
Query: 102 PAQH--PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIG 159
P+QH P+P P P Q + C Q D P Q C + P D IG
Sbjct: 255 PSQHLLPHPKPSHPRPPTQKP---LGRCFQ---DTLPKQPCGSNPLPGLTKQEDCCGSIG 308
Query: 160 PECVDIDECRYRYCQHRCVNLPGSFR----CQCEPGFQLGPNNRSCVDVNECDMGAPCEQ 215
+ Q+ V PG R C G++ N+ C D+NEC M C
Sbjct: 309 TAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKR-LNSTHCQDINECAMPGVCRH 367
Query: 216 -RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274
C N+ G++ C C G+ L C I + LC +R V+ C P
Sbjct: 368 GDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEEKSLC-FRLVSP--EHQCQHP---- 418
Query: 275 LLATRLCQDIDECESGAHQCSEAQTC 300
L TRL + + C G + Q C
Sbjct: 419 -LTTRLTRQLCCCSVGKAWGARCQRC 443
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/84 (35%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 255 QYRCVNEPG----RFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
QY V +PG CPQGY+ L + CQDI+EC C C+N G YRCV
Sbjct: 323 QYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPG-VCRHGD-CLNNPGSYRCV 380
Query: 311 DTNRCVEPYIQVSENRCLCPASNP 334
P + +R C A P
Sbjct: 381 -----CPPGHSLGPSRTQCIADKP 399
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 22/115 (19%)
Query: 4 CASCLPGSLLLWALLLLLLGSAS-PQDSEEPDS-----------------YTECTDGYEW 45
C + S W LLLG +DS E DS EC G++
Sbjct: 1139 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1198
Query: 46 DPDSQHCRDVNECLTIPE---ACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
D C D++EC + + CK E +C+N G + C+ ++ + HG P
Sbjct: 1199 DASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKAGFARSRPHGACVP 1252
Score = 36.6 bits (83), Expect = 0.047
Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 3/44 (6%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL 81
+C GY+ +S HC+D+NEC +P C+ C+N+ G Y C+
Sbjct: 340 DCPQGYK-RLNSTHCQDINEC-AMPGVCR-HGDCLNNPGSYRCV 380
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 189 bits (479), Expect = 6e-48
Identities = 104/314 (33%), Positives = 143/314 (45%), Gaps = 54/314 (17%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C G+E P + C D+NEC C+ KC+N G Y C
Sbjct: 1184 DCPLGHELSPSREDCVDINECSLSDNLCRNG-KCVNMIGTYQC----------------- 1225
Query: 98 PPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
C PGY+ D+ C D+DEC C C N GSY+C+C +GY
Sbjct: 1226 ----------SCNPGYQATPDRQGCTDIDECMIMNGGC--DTQCTNSEGSYECSCSEGYA 1273
Query: 157 KI--GPECVDIDECRYR--YCQ-HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
+ G C DIDEC C +C N+PG +RC C GF + ++C+DVNECD+ +
Sbjct: 1274 LMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNS 1333
Query: 212 PCEQ--RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR--CVNEPGRFSC 267
C N+ G+F+C C GY + + C+D+DEC ++ C C+N PG F C
Sbjct: 1334 NICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC 1393
Query: 268 HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV-------------DTNR 314
C +G+ + C D+DEC +G HQCS CVN G YRC D +
Sbjct: 1394 SCREGWIGNGIK-CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDE 1452
Query: 315 CVEPYIQVSENRCL 328
C E +CL
Sbjct: 1453 CAENINLCENGQCL 1466
Score = 169 bits (427), Expect = 6e-42
Identities = 109/318 (34%), Positives = 147/318 (46%), Gaps = 35/318 (11%)
Query: 19 LLLLGSASPQDSEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGG 77
+++ G Q + SY C++GY PD + C D++EC P+ C G +C N G
Sbjct: 1247 MIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGG-QCTNIPGE 1305
Query: 78 YLCL----------PRSAAVIND--------LHGEGPPPPVPPAQHPNPCPPGYE-PDDQ 118
Y CL ++ +N+ + GE H C GY
Sbjct: 1306 YRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH---CQLGYSVKKGT 1362
Query: 119 DSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQ---- 174
C DVDEC H+C C N+PGS++C+C +G+ G +C+D+DEC Q
Sbjct: 1363 TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSIN 1422
Query: 175 HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP-CEQ-RCFNSYGTFLCRCHQGY 232
+CVN PGS+RC C GF + +C DV+EC CE +C N G + C C G+
Sbjct: 1423 AQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGF 1480
Query: 233 ELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGA 291
D SC DIDECS+ + C N PG F C C GY+L T C DIDEC
Sbjct: 1481 TPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPI 1540
Query: 292 HQCSEAQTCVNFHGGYRC 309
+ C CVN G Y C
Sbjct: 1541 N-CVNG-LCVNTPGRYEC 1556
Score = 165 bits (417), Expect = 9e-41
Identities = 95/268 (35%), Positives = 126/268 (47%), Gaps = 40/268 (14%)
Query: 53 RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPG 112
+D+NEC P C KC N G + C C G
Sbjct: 1072 KDINECKAFPGMCTYG-KCRNTIGSFKCR---------------------------CNSG 1103
Query: 113 YEPD-DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK---IGPECVDIDEC 168
+ D ++ +C D+DEC + C S C N PGS++C C +GY + C+DIDEC
Sbjct: 1104 FALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFECECFEGYESGFMMMKNCMDIDEC 1162
Query: 169 RYRYCQHR---CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP-CEQ-RCFNSYGT 223
R CVN GSF+C C G +L P+ CVD+NEC + C +C N GT
Sbjct: 1163 ERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGT 1222
Query: 224 FLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQ 282
+ C C+ GY+ D C+DIDEC + C +C N G + C C +GY L+ R C
Sbjct: 1223 YQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1282
Query: 283 DIDECESGAHQCSEAQTCVNFHGGYRCV 310
DIDECE+ C Q C N G YRC+
Sbjct: 1283 DIDECENNPDICDGGQ-CTNIPGEYRCL 1309
Score = 164 bits (415), Expect = 1e-40
Identities = 85/244 (34%), Positives = 117/244 (47%), Gaps = 32/244 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY + C DV+EC C C+N G + C R + N +
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGI------- 1404
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI 158
C+D+DEC+ H C + C N PGSY+C C +G+
Sbjct: 1405 ---------------------KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD 1443
Query: 159 GPECVDIDEC--RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCE- 214
G C D+DEC C++ +C+N+PG++RC+CE GF ++RSC D++EC C
Sbjct: 1444 GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVF 1503
Query: 215 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274
C N G F C C GYEL R G +C+DIDEC+ CVN PGR+ C+CP +Q
Sbjct: 1504 GTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQ 1563
Query: 275 LLAT 278
L T
Sbjct: 1564 LNPT 1567
Score = 162 bits (410), Expect = 6e-40
Identities = 98/300 (32%), Positives = 137/300 (45%), Gaps = 51/300 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY+ PD Q C D++EC+ + C + +C N G Y C
Sbjct: 1227 CNPGYQATPDRQGCTDIDECMIMNGGC--DTQCTNSEGSYEC------------------ 1266
Query: 99 PVPPAQHPNPCPPGYE--PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
C GY PD + SC D+DEC C Q C N+PG Y+C C DG+
Sbjct: 1267 ---------SCSEGYALMPDGR-SCADIDECENNPDICDGGQ-CTNIPGEYRCLCYDGFM 1315
Query: 157 KI--GPECVDIDEC--RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
C+D++EC C C N GSF C C+ G+ + C DV+EC++GA
Sbjct: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
Query: 212 -PCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEPGRFS 266
C+ C N G+F C C +G+ +G C D+DECS ++ C +CVN PG +
Sbjct: 1376 HNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
Query: 267 CHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR 326
C C +G+ C D+DEC + C Q C+N G YRC C + S++R
Sbjct: 1434 CACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRC----ECEMGFTPASDSR 1487
Score = 161 bits (407), Expect = 1e-39
Identities = 95/297 (31%), Positives = 133/297 (44%), Gaps = 31/297 (10%)
Query: 53 RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPC--- 109
RD++EC +P C +CIN G + C + D+ G +Q P PC
Sbjct: 2448 RDIDECKVMPNLCTNG-QCINTMGSFRCFCK-VGYTTDISGTSCIDLDECSQSPKPCNYI 2505
Query: 110 ------------PPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
P GY +D +C D+DEC H+C+ C N G + C CP G+
Sbjct: 2506 CKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFL--CVNTLGGFTCKCPPGFT 2563
Query: 157 KIGPECVDIDECRYR--YCQHR--CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP 212
+ C+D +EC + C + C N PGSF C+C+ GF L +C DV+ECD
Sbjct: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR 2623
Query: 213 CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQG 272
C+ C N G + C C QGY H C D +ECS + C N G + C CP G
Sbjct: 2624 CQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSG 2683
Query: 273 YQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL 328
+ + C D++EC S + C+ C N GGY C C Y +V + C+
Sbjct: 2684 FSFDQFSSACHDVNECSSSKNPCNYG--CSNTEGGYLC----GCPPGYYRVGQGHCV 2734
Score = 159 bits (402), Expect = 5e-39
Identities = 105/309 (33%), Positives = 148/309 (47%), Gaps = 48/309 (15%)
Query: 42 GYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVP 101
G+ +D + D++EC IP C + CIN G + C
Sbjct: 1796 GFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSFRC--------------------- 1833
Query: 102 PAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGP 160
CP G+ +D C D+DEC+ + C+ + DC N PGSY+C C G+ K+ P
Sbjct: 1834 ------ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGF-KLSP 1886
Query: 161 E--CVDIDECRY--RYCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQ 215
CVD +EC C H CV+L GS++C C GF+ + C+DV+EC+
Sbjct: 1887 NGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNG 1946
Query: 216 RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC-SYSSYLCQY-RCVNEPGRFSCHCPQGY 273
C N+ G++ C C+ G+EL + C DIDEC S+ +C+ RC NE G F C C +GY
Sbjct: 1947 TCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY 2005
Query: 274 QLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPAS 332
+L + C D +EC + CS TC N G +RC+ C Y SEN C
Sbjct: 2006 ELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI----CPPGYEVKSEN---CIDI 2057
Query: 333 NPLCREQPS 341
N C E P+
Sbjct: 2058 NE-CDEDPN 2065
Score = 148 bits (374), Expect = 8e-36
Identities = 78/247 (31%), Positives = 107/247 (43%), Gaps = 34/247 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY D + C+D++EC T C + C+N GG+ C
Sbjct: 2517 CPRGYVLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTC------------------ 2556
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-- 156
CPPG+ +C+D +EC C C N PGS+ C C G+
Sbjct: 2557 ---------KCPPGF-TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLD 2606
Query: 157 KIGPECVDIDECRYRY-CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC-E 214
G C D+DEC + CQH C N+ G +RC C G+ CVD NEC C
Sbjct: 2607 ATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGS 2666
Query: 215 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ 274
C+N+ G++ C C G+ + +C D++ECS S C Y C N G + C CP GY
Sbjct: 2667 ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYY 2726
Query: 275 LLATRLC 281
+ C
Sbjct: 2727 RVGQGHC 2733
Score = 146 bits (368), Expect = 4e-35
Identities = 110/348 (31%), Positives = 146/348 (41%), Gaps = 66/348 (18%)
Query: 21 LLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC 80
L GS SP + + C ++ S++C D+NEC P C C N GG+ C
Sbjct: 2023 LPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFG-SCTNTPGGFQC 2081
Query: 81 LPRSAAVIND---------------------------------------LHGEGPPPPVP 101
L V++D + GEG P
Sbjct: 2082 LCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCE 2141
Query: 102 PAQHPNP------CPPGYE--PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPD 153
+ CP G+ P D+ DV+EC ++ C Q C N GS++C CP
Sbjct: 2142 LCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGSFRCECPM 2200
Query: 154 GYRK--IGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDM 209
GY G CVD DEC C + C N+ GSF C C GF+ GP +C D+NEC
Sbjct: 2201 GYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM-MNCEDINECAQ 2259
Query: 210 GAP-CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR---CVNEPGRF 265
C RC N++G++ C C GY L D C D+DEC+ + C+ R C N G F
Sbjct: 2260 NPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTF 2319
Query: 266 SCHCPQGYQLLATRL----CQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C CP G +A R C D +EC + C + CVN G YRC
Sbjct: 2320 MCICPPG---MARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRC 2363
Score = 145 bits (365), Expect = 9e-35
Identities = 122/392 (31%), Positives = 154/392 (39%), Gaps = 81/392 (20%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC---------------LPR 83
C +G W + C D++EC C +C+N G Y C +
Sbjct: 1395 CREG--WIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDE 1452
Query: 84 SAAVINDLHGEGPPPPVPPAQHPNPCPPGYEP-DDQDSCVDVDECAQALHDCRPSQDCHN 142
A IN L G VP A C G+ P D SC D+DEC+ + C+N
Sbjct: 1453 CAENIN-LCENGQCLNVPGAYRCE-CEMGFTPASDSRSCQDIDECS--FQNICVFGTCNN 1508
Query: 143 LPGSYQCTCPDGYR--KIGPECVDIDECR--YRYCQHRCVNLPGSFRCQCEPGFQLGPNN 198
LPG + C C DGY + G C DIDEC CVN PG + C C P FQL P
Sbjct: 1509 LPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTG 1568
Query: 199 RSCVD--VNECDM---------------------------------GAPCEQRC--FNSY 221
CVD V C + G PCE C NS
Sbjct: 1569 VGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE-TCPPVNST 1627
Query: 222 GTF-LCRCHQGYELHRDGFSCSDIDECSYSSYLCQ-YRCVNEPGRFSCHCPQGYQLLA-T 278
+ LC +G+ + DIDEC LCQ C+N G F C CPQGY L T
Sbjct: 1628 EYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDT 1687
Query: 279 RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCRE 338
R+C+DIDEC + C TC N G Y C+ C Y+QV+ C +
Sbjct: 1688 RICEDIDECFAHPGVCGPG-TCYNTLGNYTCI----CPPEYMQVN--------GGHNCMD 1734
Query: 339 QPSSIVHR-YMTITSERSVPADVFQIQATSVY 369
S +R Y T E +P +V + Y
Sbjct: 1735 MRKSFCYRSYNGTTCENELPFNVTKRMCCCTY 1766
Score = 141 bits (356), Expect = 1e-33
Identities = 72/191 (37%), Positives = 105/191 (54%), Gaps = 8/191 (4%)
Query: 124 VDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK-IGPECVDIDECRYRYCQHR-CVNLP 181
+D C + C + C SY+C C GY++ +C+D+DEC C + CVN P
Sbjct: 495 IDICKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTP 553
Query: 182 GSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGF 239
GS+ C+C GFQ P ++C+D++EC G C+ RC N+ G+F C C+ G+EL DG
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
Query: 240 SCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQ 298
+C D DEC+ ++ C+NE G F C C G+ L R C D+DEC++ C
Sbjct: 614 NCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPG-ICMNGH 672
Query: 299 TCVNFHGGYRC 309
C+N G +RC
Sbjct: 673 -CINSEGSFRC 682
Score = 138 bits (348), Expect = 9e-33
Identities = 82/232 (35%), Positives = 110/232 (47%), Gaps = 11/232 (4%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDID 166
C GY+ D C+DVDEC + C + DC N PGSY C C G+++ + C+DID
Sbjct: 521 CNMGYKQDANGDCIDVDECTS--NPCT-NGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 167 ECRYR--YCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC-EQRCFNSYG 222
EC C++ RCVN GSF+C C GF+L + ++CVD +EC C C N G
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
Query: 223 TFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQL-LATRLC 281
+F C C G+ L +G C+D+DEC C+N G F C CP G + + R+C
Sbjct: 638 SFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC 697
Query: 282 QDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASN 333
D S + + CV G C P E CPA N
Sbjct: 698 VD-THMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKN 748
Score = 134 bits (336), Expect = 2e-31
Identities = 98/353 (27%), Positives = 138/353 (39%), Gaps = 112/353 (31%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C +GYE PD ++C D NEC+ +P +C C N G + C+
Sbjct: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRCI----------------- 2042
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY--R 156
CPPGYE ++ C+D++EC + + C C N PG +QC CP G+
Sbjct: 2043 ----------CPPGYEVKSEN-CIDINECDEDPNICLFGS-CTNTPGGFQCLCPPGFVLS 2090
Query: 157 KIGPECVDIDE--CRYRYCQHRCVNLPGSF-----RCQC-------------------EP 190
G C D + C + +C ++P +F +C C E
Sbjct: 2091 DNGRRCFDTRQSFCFTNFENGKC-SVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEV 2149
Query: 191 GFQ-LGPNNRSCV--------DVNEC--DMGAPCEQRCFNSYGTFLCRCHQGYELHRDG- 238
FQ L P V DVNEC G +C N+ G+F C C GY L G
Sbjct: 2150 AFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGV 2209
Query: 239 ---------------------------------------FSCSDIDECSYSSYLCQYRCV 259
+C DI+EC+ + LC +RC+
Sbjct: 2210 RCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCM 2269
Query: 260 NEPGRFSCHCPQGYQLLA-TRLCQDIDECESGAHQC-SEAQTCVNFHGGYRCV 310
N G + C CP GY L ++C+D+DEC G H C S C N G + C+
Sbjct: 2270 NTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI 2322
Score = 130 bits (328), Expect = 2e-30
Identities = 109/389 (28%), Positives = 156/389 (40%), Gaps = 90/389 (23%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIP---EACKGEMKCIN---------HYGGYL 79
P SY+ C GY + +++ C D+NEC + P AC+ + N G +
Sbjct: 830 PGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLI 889
Query: 80 CLP-------------RSAAVINDLH---------GEGPPPPVPPAQHPNPCPPGYEPDD 117
C+ R IN G P + CP G
Sbjct: 890 CIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIK 949
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK--IGPECVDI--DECRYRYC 173
+C DV+EC C P+ C N GS+ C CP+G G C+DI ++C ++
Sbjct: 950 GVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD 1008
Query: 174 QHRCVN-LPGSFR---CQCEPGFQLGPNNRSCV--------------------------- 202
+ C++ +PG FR C C G G C
Sbjct: 1009 EDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGR 1068
Query: 203 ----DVNECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-Q 255
D+NEC G +C N+ G+F CRC+ G+ L + +C+DIDEC S LC
Sbjct: 1069 PFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS 1128
Query: 256 YRCVNEPGRFSCHCPQGYQ--LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC---- 309
CVN PG F C C +GY+ + + C DIDECE C TCVN G ++C
Sbjct: 1129 GICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPL 1187
Query: 310 -VDTNRCVEPYIQVSENRCLCPASNPLCR 337
+ + E + ++E C S+ LCR
Sbjct: 1188 GHELSPSREDCVDINE----CSLSDNLCR 1212
Score = 127 bits (318), Expect = 3e-29
Identities = 98/360 (27%), Positives = 140/360 (38%), Gaps = 88/360 (24%)
Query: 36 YTECT--DGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93
YT C +G+ +P + D++EC +P C+G CIN +G + C
Sbjct: 1630 YTLCPGGEGFRPNPITIILEDIDECQELPGLCQGG-NCINTFGSFQC------------- 1675
Query: 94 EGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
CP GY +D C D+DEC C P C+N G+Y C CP
Sbjct: 1676 --------------ECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCICP 1720
Query: 153 DGYRKI--GPECVDIDE--CRYRYCQHRCVN----------------------------- 179
Y ++ G C+D+ + C Y C N
Sbjct: 1721 PEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCP 1780
Query: 180 LPGS--FRCQCE--PGFQLGPNNRSCVDVNECD--MGAPCEQRCFNSYGTFLCRCHQGYE 233
PG+ F+ C PGF + VD++EC G C N G+F C C G+
Sbjct: 1781 TPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFS 1840
Query: 234 LHRDGFSCSDIDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQLLATRLCQDIDECESGA 291
+ C DIDECS LCQ C+N PG + C C G++L C D +EC
Sbjct: 1841 YNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIP 1900
Query: 292 HQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLC---------PASNPLCREQPSS 342
+ CS CV+ G Y+C+ N + S+++ +C P N C+ S
Sbjct: 1901 NVCSHG-LCVDLQGSYQCICHNG-----FKASQDQTMCMDVDECERHPCGNGTCKNTVGS 1954
Score = 124 bits (310), Expect = 2e-28
Identities = 95/310 (30%), Positives = 128/310 (41%), Gaps = 70/310 (22%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
EC GY D C D +EC +I C G C N G + C
Sbjct: 2197 ECPMGYNLDYTGVRCVDTDEC-SIGNPC-GNGTCTNVIGSFEC----------------- 2237
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY-- 155
C G+EP +C D++ECAQ C + C N GSY+CTCP GY
Sbjct: 2238 ----------NCNEGFEPGPMMNCEDINECAQNPLLC--AFRCMNTFGSYECTCPIGYAL 2285
Query: 156 RKIGPECVDIDECR--YRYCQHR---CVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DM 209
R+ C D+DEC C+ R C NL G+F C C PG P+ CVD NEC
Sbjct: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345
Query: 210 GAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDE-----------CSYSS----YL 253
CE RC N G++ C C++G++ G C D + C +S +
Sbjct: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLV 2405
Query: 254 CQYRCVNEPGRFSCH----CPQGYQLLATRLC----------QDIDECESGAHQCSEAQT 299
+ C + GR H CP ++C +DIDEC+ + C+ Q
Sbjct: 2406 TKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQ- 2464
Query: 300 CVNFHGGYRC 309
C+N G +RC
Sbjct: 2465 CINTMGSFRC 2474
Score = 121 bits (304), Expect = 1e-27
Identities = 101/353 (28%), Positives = 143/353 (40%), Gaps = 76/353 (21%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-------PRS 84
P SY EC G++ P+ C D NECL IP C + C++ G Y C+ +
Sbjct: 1871 PGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCSHGL-CVDLQGSYQCICHNGFKASQD 1928
Query: 85 AAVINDLHGEGPPPPVPPAQHPNP-------CPPGYEPDDQDSCVDVDECAQALHDCRPS 137
+ D+ E P N C PG+E + C+D+DEC+ +
Sbjct: 1929 QTMCMDVD-ECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN 1987
Query: 138 QDCHNLPGSYQCTCPDGYRKI--GPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGF 192
C N GS++C C +GY G C+D +EC C NL GSFRC C PG+
Sbjct: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGY 2047
Query: 193 QLGPNNRSCVDVNECDMGAPC--EQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDE---- 246
++ N C+D+NECD C N+ G F C C G+ L +G C D +
Sbjct: 2048 EVKSEN--CIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCF 2105
Query: 247 -------CS----YSSYLCQYRCVNEPGRF---SCH-CPQGYQLLATRLC---------- 281
CS +++ + C PG C CP+ ++ LC
Sbjct: 2106 TNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSL 2165
Query: 282 ----QDIDECESGAHQCSEAQTCVNFHG---------------GYRCVDTNRC 315
+D++EC CS Q C+N G G RCVDT+ C
Sbjct: 2166 HDTREDVNECLESPGICSNGQ-CINTDGSFRCECPMGYNLDYTGVRCVDTDEC 2217
Score = 116 bits (291), Expect = 4e-26
Identities = 101/354 (28%), Positives = 136/354 (38%), Gaps = 85/354 (24%)
Query: 36 YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEG 95
Y +C G++ P Q C D++EC+ CK +C+N G + C+
Sbjct: 557 YCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNTDGSFQCI-------------- 601
Query: 96 PPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG 154
C G+E D +CVD DEC + C C N GS++C C G
Sbjct: 602 -------------CNAGFELTTDGKNCVDHDECT-TTNMCLNGM-CINEDGSFKCICKPG 646
Query: 155 Y--RKIGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDV------ 204
+ G C D+DEC+ C + C+N GSFRC C PG +G + R CVD
Sbjct: 647 FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTC 706
Query: 205 -------------------NEC-------DMGAPCEQRCFNSYGTFLCRCHQGYELHRDG 238
+EC G PC+ + F C G + DG
Sbjct: 707 YGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG 766
Query: 239 FSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSE 296
DI+EC+ +C C N G + C+C GY+ A+ R C DIDEC C
Sbjct: 767 ---RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDN 823
Query: 297 AQTCVNFHGGYRCVDTNRCVEPYIQVSE-------NRCLC-PASNPLCREQPSS 342
C N G Y C C Y+ +E N C P N CR S
Sbjct: 824 G-LCRNTPGSYSCT----CPPGYVFRTETETCEDINECESNPCVNGACRNNLGS 872
Score = 114 bits (284), Expect = 2e-25
Identities = 92/342 (26%), Positives = 125/342 (36%), Gaps = 75/342 (21%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVINDL 91
C G+ P+ ++C DV+EC T P C CIN G + C + V D
Sbjct: 643 CKPGFVLAPNGRYCTDVDECQT-PGICMNG-HCINSEGSFRCDCPPGLAVGMDGRVCVDT 700
Query: 92 HGEGP----------PPPVPPA----------------QHPNPCPPGYEPDDQDSCV--- 122
H P P A + PCP + C
Sbjct: 701 HMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGV 760
Query: 123 -------DVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK--IGPECVDIDECRYR-- 171
D++ECA C + C NL GSY+C C GY G C+DIDEC
Sbjct: 761 GITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRL 819
Query: 172 YCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ 230
C + C N PGS+ C C PG+ +C D+NEC+ C N+ G+F C C
Sbjct: 820 LCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSP 879
Query: 231 GYELHRDGFSCSD------------------IDECSYSSYLC-----QYRCVNEPGRFSC 267
G +L G C D I+ + S C + E
Sbjct: 880 GSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDT 939
Query: 268 HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
CP+G + C+D++ECE C + CVN G + C
Sbjct: 940 ACPRGLARIKGVTCEDVNECEVFPGVCPNGR-CVNSKGSFHC 980
Score = 108 bits (270), Expect = 1e-23
Identities = 93/309 (30%), Positives = 119/309 (38%), Gaps = 73/309 (23%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G+E D ++C D +EC T G CIN G + C+
Sbjct: 602 CNAGFELTTDGKNCVDHDECTTTNMCLNG--MCINEDGSFKCI----------------- 642
Query: 99 PVPPAQHPNPCPPGY--EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
C PG+ P+ + C DVDEC Q C C N GS++C CP G
Sbjct: 643 ----------CKPGFVLAPNGR-YCTDVDEC-QTPGICMNGH-CINSEGSFRCDCPPGLA 689
Query: 157 --KIGPECVDI---DECRYRYCQHRCVN-LPGSFR----CQCEPGFQLGPNNRSCV---- 202
G CVD C + CV PG+ C P + G + C
Sbjct: 690 VGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNS 749
Query: 203 ------------------DVNEC--DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCS 242
D+NEC D C N G++ C C+ GYE G +C
Sbjct: 750 AEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI 809
Query: 243 DIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQCSEAQTC 300
DIDEC + LC C N PG +SC CP GY T C+DI+ECES + C C
Sbjct: 810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECES--NPCVNG-AC 866
Query: 301 VNFHGGYRC 309
N G + C
Sbjct: 867 RNNLGSFNC 875
Score = 97.8 bits (242), Expect = 2e-20
Identities = 105/407 (25%), Positives = 155/407 (38%), Gaps = 92/407 (22%)
Query: 24 SASPQDSEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL- 81
S + Q P SY C++G+ D + C DV+EC C+ +C+N G Y C
Sbjct: 1420 SINAQCVNTPGSYRCACSEGFTGDGFT--CSDVDECAENINLCENG-QCLNVPGAYRCEC 1476
Query: 82 ---------PRSAAVINDLHGE-----GPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDE 126
RS I++ + G +P H C GYE D +C D+DE
Sbjct: 1477 EMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI-CDDGYELDRTGGNCTDIDE 1535
Query: 127 CAQALHDCRPSQDCHNLPGSYQCTCPDGYR--KIGPECVD--IDECRYRY---------C 173
CA ++ C N PG Y+C CP ++ G CVD + C ++ C
Sbjct: 1536 CADPINCVNGL--CVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSC 1593
Query: 174 QHR----------CVNLPGSFRCQCEP-----------------GFQLGPNNRSCVDVNE 206
C +L ++ CE GF+ P D++E
Sbjct: 1594 NTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDE 1653
Query: 207 C-DMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPG 263
C ++ C+ C N++G+F C C QGY L D C DIDEC +C C N G
Sbjct: 1654 CQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLG 1713
Query: 264 RFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQT--CVNFHGGYRCVDTNRCVEPYIQ 321
++C CP Y + +G H C + + C + G C + E
Sbjct: 1714 NYTCICPPEYMQV------------NGGHNCMDMRKSFCYRSYNGTTCEN-----ELPFN 1756
Query: 322 VSENRCLC-----PASNPLCREQPSSIVHRYMTITSERSVPADVFQI 363
V++ C C A N C P+ + TI ++P F I
Sbjct: 1757 VTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICG--NIPGFTFDI 1801
Score = 81.6 bits (200), Expect = 1e-15
Identities = 95/370 (25%), Positives = 139/370 (37%), Gaps = 110/370 (29%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GYE D ++C D++ECL C + C N G Y C
Sbjct: 795 CNSGYEPDASGRNCIDIDECLVNRLLCDNGL-CRNTPGSYSCT----------------- 836
Query: 99 PVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR- 156
CPPGY + ++C D++EC + C + C N GS+ C C G +
Sbjct: 837 ----------CPPGYVFRTETETCEDINECES--NPC-VNGACRNNLGSFNCECSPGSKL 883
Query: 157 -KIGPECVDI--DECRYRYCQHRC-VNLPGSF------------------RCQCEPGFQL 194
G C+D C RC VN+ G+ RC+ +
Sbjct: 884 SSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPR 943
Query: 195 G---PNNRSCVDVNECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDI--DEC 247
G +C DVNEC++ G RC NS G+F C C +G L G C DI ++C
Sbjct: 944 GLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQC 1003
Query: 248 SYSSYLCQYRCVNE-PGRF---SCHCPQG-----------------YQLLATR------- 279
Y + + C++ PG+F +C C G Y+ L R
Sbjct: 1004 -YLKW-DEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
Query: 280 --------LCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY-IQVSENRCL-- 328
+DI+EC++ C+ + C N G ++C RC + + + E C
Sbjct: 1062 GDVLTGRPFYKDINECKAFPGMCTYGK-CRNTIGSFKC----RCNSGFALDMEERNCTDI 1116
Query: 329 --CPASNPLC 336
C S LC
Sbjct: 1117 DECRISPDLC 1126
Score = 80.1 bits (196), Expect = 4e-15
Identities = 88/373 (23%), Positives = 129/373 (34%), Gaps = 89/373 (23%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C DGYE D +C D++EC P C + C+N G Y C
Sbjct: 1517 CDDGYELDRTGGNCTDIDECAD-PINCVNGL-CVNTPGRYEC------------------ 1556
Query: 99 PVPPAQHPNPCPPGYEPDDQDSC---------------------VDVDECAQALHDC--R 135
PP NP G + +C V C +L
Sbjct: 1557 NCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGN 1616
Query: 136 PSQDCHNLPGS-YQCTCP--DGYRKIGPECV--DIDECRYR--YCQH-RCVNLPGSFRCQ 187
P + C + + Y CP +G+R + DIDEC+ CQ C+N GSF+C+
Sbjct: 1617 PCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCE 1676
Query: 188 CEPGFQLGPNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDID 245
C G+ L + R C D++EC G C+N+ G + C C Y G +C D+
Sbjct: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
Query: 246 EC----SYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQ------------------- 282
+ SY+ C+ + C C + C+
Sbjct: 1737 KSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPG 1796
Query: 283 -----------DIDECESGAHQCSEAQTCVNFHGGYRC-VDTNRCVEPYIQVSENRCLCP 330
DIDEC+ C+ C+N G +RC T + V E+ C
Sbjct: 1797 FTFDIHTGKAVDIDECKEIPGICANG-VCINQIGSFRCECPTGFSYNDLLLVCEDIDECS 1855
Query: 331 ASNPLCREQPSSI 343
+ LC+ I
Sbjct: 1856 NGDNLCQRNADCI 1868
Score = 73.6 bits (179), Expect = 3e-13
Identities = 50/166 (30%), Positives = 68/166 (40%), Gaps = 38/166 (22%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P S++ EC G+ D +C DV+EC G C N GGY C
Sbjct: 2592 PGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG---CQNILGGYRC----------- 2637
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQ-DSCVDVDECAQALHDCRPSQDCHNLPGSYQCT 150
CP GY Q + CVD +EC+ + S C+N GSY+C
Sbjct: 2638 ----------------GCPQGYIQHYQWNQCVDENECSNP--NACGSASCYNTLGSYKCA 2679
Query: 151 CPDGYR--KIGPECVDIDEC--RYRYCQHRCVNLPGSFRCQCEPGF 192
CP G+ + C D++EC C + C N G + C C PG+
Sbjct: 2680 CPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
Score = 70.9 bits (172), Expect = 2e-12
Identities = 43/120 (35%), Positives = 57/120 (47%), Gaps = 9/120 (7%)
Query: 162 CVDIDECRY--RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDM-GAPCEQ-R 216
C D+DEC+ CQ C+N GSF C+C G + + C D++EC + CE
Sbjct: 274 CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGE 333
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNE-PGRFS---CHCPQG 272
C N+ G++ C C +GY DG C D S L RC E PGR + C C G
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 69.3 bits (168), Expect = 7e-12
Identities = 81/336 (24%), Positives = 109/336 (32%), Gaps = 111/336 (33%)
Query: 96 PPPPVPPAQHPNP--------------CPPGYEPD------------DQDSCVDVDECAQ 129
PPPP PP P P P Y + QD + C
Sbjct: 32 PPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGS 91
Query: 130 ALHD-CRPSQDCHNLPGSYQC-------TCPDGYRKIGPECV--------DIDECRYRYC 173
H C P LPG QC +C DG+ C + C
Sbjct: 92 RFHSYCCPGWK--TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQC 149
Query: 174 QHRCVN--LPGSFRCQCEPGFQLGP------------NNRSCVDVNECDM-----GAPCE 214
RC+N CQC+ G+ +G N C+ N C G CE
Sbjct: 150 SVRCMNGGTCADDHCQCQKGY-IGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCE 208
Query: 215 QR-----CFNSYGTFLCR----------------------------------CHQGYELH 235
+ CF +C+ C +G+ +
Sbjct: 209 RDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPN 268
Query: 236 RDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGY-QLLATRLCQDIDECESGAHQ 293
+C D+DEC +CQ C+N G F C CP G+ Q T+ C+DIDEC
Sbjct: 269 IRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGI 328
Query: 294 CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSE-NRCL 328
C E C N G Y CV C Y+ ++ +RC+
Sbjct: 329 C-ETGECSNTVGSYFCV----CPRGYVTSTDGSRCI 359
Score = 69.3 bits (168), Expect = 7e-12
Identities = 49/148 (33%), Positives = 67/148 (45%), Gaps = 13/148 (8%)
Query: 95 GPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPD 153
G P + PAQ P PC G+ P+ + +C DVDEC QA+ +C N GS++C CP
Sbjct: 248 GHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDEC-QAIPGICQGGNCINTVGSFECRCPA 305
Query: 154 GYR--KIGPECVDIDECRY--RYCQ-HRCVNLPGSFRCQCEPGFQLGPNNRSCVD--VNE 206
G++ + +C DIDEC C+ C N GS+ C C G+ + C+D
Sbjct: 306 GHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGM 365
Query: 207 CDMG---APCEQRCFNSYGTFLCRCHQG 231
C G C Q C C G
Sbjct: 366 CFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 65.9 bits (159), Expect = 7e-11
Identities = 57/198 (28%), Positives = 75/198 (37%), Gaps = 39/198 (19%)
Query: 4 CASCLPGSLLLWALLLLLLGSASPQDSEE-PDSYTECTDGYEWDPDSQHCRDVNECLTIP 62
C L G + L +G A E P C G+ + + C+DV+EC IP
Sbjct: 225 CQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIP 284
Query: 63 EACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGY-EPDDQDSC 121
C+G CIN G + C CP G+ + + C
Sbjct: 285 GICQGG-NCINTVGSFEC---------------------------RCPAGHKQSETTQKC 316
Query: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY--RKIGPECVD--IDECRYRYCQHRC 177
D+DEC+ C + +C N GSY C CP GY G C+D C RC
Sbjct: 317 EDIDECSIIPGICE-TGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRC 375
Query: 178 V-NLPG---SFRCQCEPG 191
LPG +C CEPG
Sbjct: 376 AQELPGRMTKMQCCCEPG 393
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 181 bits (459), Expect = 1e-45
Identities = 114/363 (31%), Positives = 163/363 (44%), Gaps = 63/363 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G+ D ++CRDV+EC C+ +C+N G Y CLP
Sbjct: 3469 CPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP---------------- 3512
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI 158
C PG+ D C DVDEC + L DC +Q C N PG ++C+CP GYR
Sbjct: 3513 ---------DCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQ 3563
Query: 159 GPE--CVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--- 211
GP C+D++EC + C ++C NL GS+RC C PG L + ++C +
Sbjct: 3564 GPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTV 3623
Query: 212 -----------PCEQRCFNSYGTFL--------------CRCHQGYELHRDGFSCSDIDE 246
P SY ++ C G+ + ++G C+D+DE
Sbjct: 3624 SHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGF-IRQNGV-CTDLDE 3681
Query: 247 CSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHG 305
C + LCQ+ C N G + C CP GY+LL + + CQDI+ECE + +C Q C N G
Sbjct: 3682 CRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRG 3740
Query: 306 GYRCVDTNRCVEPYIQ-VSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQ 364
Y+CVDT C Y Q S C S PS++ +R + + DV ++
Sbjct: 3741 SYQCVDT-PCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLT 3799
Query: 365 ATS 367
A S
Sbjct: 3800 AFS 3802
Score = 125 bits (314), Expect = 8e-29
Identities = 71/180 (39%), Positives = 92/180 (51%), Gaps = 15/180 (8%)
Query: 109 CPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDI 165
CP G+E D Q + CVD DEC+ C S C N PG + CTCP G+ + C D+
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDV 3485
Query: 166 DECRY--RYCQH--RCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP---CEQR 216
DEC + C+ RCVNL GS+RC C PGF++ + C DV+EC G Q
Sbjct: 3486 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQL 3544
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N+ G C C +GY + C D++EC C Y+C N G + C CP G LL
Sbjct: 3545 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 3604
Score = 118 bits (296), Expect = 9e-27
Identities = 69/172 (40%), Positives = 87/172 (50%), Gaps = 15/172 (8%)
Query: 151 CPDGYR--KIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
CP+G+ G CVD DEC C H C+N PG F C C GF L ++R+C DV+E
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3487
Query: 207 CDMGAP-CE--QRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR--CV 259
C A C QRC N G++ C C G+ + DG C D+DEC C Y C
Sbjct: 3488 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQLCE 3546
Query: 260 NEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
N PG C CP+GY++ L C D++EC C A C N G YRC+
Sbjct: 3547 NTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL 3596
Score = 109 bits (272), Expect = 6e-24
Identities = 60/179 (33%), Positives = 84/179 (46%), Gaps = 28/179 (15%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMG-APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDE 246
C GF+L CVD +EC G +PC C N+ G F C C G+ L D +C D+DE
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3487
Query: 247 CSYSSYLCQ--YRCVNEPGRFSC--HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVN 302
C++ ++LC+ RCVN G + C C G+++ C+D+DEC G C Q C N
Sbjct: 3488 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCEN 3547
Query: 303 FHGGYRC---------------VDTNRCVEP--------YIQVSENRCLCPASNPLCRE 338
GG+RC +D N C++ + RCLCP L R+
Sbjct: 3548 TPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRD 3606
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 181 bits (459), Expect = 1e-45
Identities = 114/363 (31%), Positives = 163/363 (44%), Gaps = 63/363 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G+ D ++CRDV+EC C+ +C+N G Y CLP
Sbjct: 4660 CPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP---------------- 4703
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI 158
C PG+ D C DVDEC + L DC +Q C N PG ++C+CP GYR
Sbjct: 4704 ---------DCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQ 4754
Query: 159 GPE--CVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--- 211
GP C+D++EC + C ++C NL GS+RC C PG L + ++C +
Sbjct: 4755 GPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTV 4814
Query: 212 -----------PCEQRCFNSYGTFL--------------CRCHQGYELHRDGFSCSDIDE 246
P SY ++ C G+ + ++G C+D+DE
Sbjct: 4815 SHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGF-IRQNGV-CTDLDE 4872
Query: 247 CSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHG 305
C + LCQ+ C N G + C CP GY+LL + + CQDI+ECE + +C Q C N G
Sbjct: 4873 CRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRG 4931
Query: 306 GYRCVDTNRCVEPYIQ-VSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQ 364
Y+CVDT C Y Q S C S PS++ +R + + DV ++
Sbjct: 4932 SYQCVDT-PCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLT 4990
Query: 365 ATS 367
A S
Sbjct: 4991 AFS 4993
Score = 125 bits (314), Expect = 8e-29
Identities = 71/180 (39%), Positives = 92/180 (51%), Gaps = 15/180 (8%)
Query: 109 CPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDI 165
CP G+E D Q + CVD DEC+ C S C N PG + CTCP G+ + C D+
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDV 4676
Query: 166 DECRY--RYCQH--RCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP---CEQR 216
DEC + C+ RCVNL GS+RC C PGF++ + C DV+EC G Q
Sbjct: 4677 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQL 4735
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N+ G C C +GY + C D++EC C Y+C N G + C CP G LL
Sbjct: 4736 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 4795
Score = 118 bits (296), Expect = 9e-27
Identities = 69/172 (40%), Positives = 87/172 (50%), Gaps = 15/172 (8%)
Query: 151 CPDGYR--KIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
CP+G+ G CVD DEC C H C+N PG F C C GF L ++R+C DV+E
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 4678
Query: 207 CDMGAP-CE--QRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR--CV 259
C A C QRC N G++ C C G+ + DG C D+DEC C Y C
Sbjct: 4679 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQLCE 4737
Query: 260 NEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
N PG C CP+GY++ L C D++EC C A C N G YRC+
Sbjct: 4738 NTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL 4787
Score = 109 bits (272), Expect = 6e-24
Identities = 60/179 (33%), Positives = 84/179 (46%), Gaps = 28/179 (15%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMG-APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDE 246
C GF+L CVD +EC G +PC C N+ G F C C G+ L D +C D+DE
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 4678
Query: 247 CSYSSYLCQ--YRCVNEPGRFSC--HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVN 302
C++ ++LC+ RCVN G + C C G+++ C+D+DEC G C Q C N
Sbjct: 4679 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCEN 4738
Query: 303 FHGGYRC---------------VDTNRCVEP--------YIQVSENRCLCPASNPLCRE 338
GG+RC +D N C++ + RCLCP L R+
Sbjct: 4739 TPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRD 4797
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 181 bits (459), Expect = 1e-45
Identities = 114/363 (31%), Positives = 163/363 (44%), Gaps = 63/363 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G+ D ++CRDV+EC C+ +C+N G Y CLP
Sbjct: 3378 CPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP---------------- 3421
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI 158
C PG+ D C DVDEC + L DC +Q C N PG ++C+CP GYR
Sbjct: 3422 ---------DCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQ 3472
Query: 159 GPE--CVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA--- 211
GP C+D++EC + C ++C NL GS+RC C PG L + ++C +
Sbjct: 3473 GPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTV 3532
Query: 212 -----------PCEQRCFNSYGTFL--------------CRCHQGYELHRDGFSCSDIDE 246
P SY ++ C G+ + ++G C+D+DE
Sbjct: 3533 SHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGF-IRQNGV-CTDLDE 3590
Query: 247 CSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHG 305
C + LCQ+ C N G + C CP GY+LL + + CQDI+ECE + +C Q C N G
Sbjct: 3591 CRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRG 3649
Query: 306 GYRCVDTNRCVEPYIQ-VSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQ 364
Y+CVDT C Y Q S C S PS++ +R + + DV ++
Sbjct: 3650 SYQCVDT-PCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLT 3708
Query: 365 ATS 367
A S
Sbjct: 3709 AFS 3711
Score = 125 bits (314), Expect = 8e-29
Identities = 71/180 (39%), Positives = 92/180 (51%), Gaps = 15/180 (8%)
Query: 109 CPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDI 165
CP G+E D Q + CVD DEC+ C S C N PG + CTCP G+ + C D+
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDV 3394
Query: 166 DECRY--RYCQH--RCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP---CEQR 216
DEC + C+ RCVNL GS+RC C PGF++ + C DV+EC G Q
Sbjct: 3395 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQL 3453
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N+ G C C +GY + C D++EC C Y+C N G + C CP G LL
Sbjct: 3454 CENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLL 3513
Score = 118 bits (296), Expect = 9e-27
Identities = 69/172 (40%), Positives = 87/172 (50%), Gaps = 15/172 (8%)
Query: 151 CPDGYR--KIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
CP+G+ G CVD DEC C H C+N PG F C C GF L ++R+C DV+E
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3396
Query: 207 CDMGAP-CE--QRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR--CV 259
C A C QRC N G++ C C G+ + DG C D+DEC C Y C
Sbjct: 3397 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGCEDVDECLEGLDDCHYNQLCE 3455
Query: 260 NEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
N PG C CP+GY++ L C D++EC C A C N G YRC+
Sbjct: 3456 NTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL 3505
Score = 109 bits (272), Expect = 6e-24
Identities = 60/179 (33%), Positives = 84/179 (46%), Gaps = 28/179 (15%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMG-APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDE 246
C GF+L CVD +EC G +PC C N+ G F C C G+ L D +C D+DE
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDE 3396
Query: 247 CSYSSYLCQ--YRCVNEPGRFSC--HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVN 302
C++ ++LC+ RCVN G + C C G+++ C+D+DEC G C Q C N
Sbjct: 3397 CAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCEN 3456
Query: 303 FHGGYRC---------------VDTNRCVEP--------YIQVSENRCLCPASNPLCRE 338
GG+RC +D N C++ + RCLCP L R+
Sbjct: 3457 TPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRD 3515
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 180 bits (457), Expect = 2e-45
Identities = 118/336 (35%), Positives = 146/336 (43%), Gaps = 45/336 (13%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL--------PR 83
P YT C G+ P C DV+EC +P C +C N G + C+ PR
Sbjct: 498 PSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPR 556
Query: 84 SAAVINDLHGEGPPPPVPPAQHPNP-------CPPGYEPDDQD-SCVDVDECAQALHDCR 135
+A ++ PPP + N CP GY+ SC DVDEC Q+ C
Sbjct: 557 AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 616
Query: 136 PSQDCHNLPGSYQCTCPDGYRKIGPECV-DIDECRYRY--C-QHRCVNLPGSFRCQCEPG 191
C NLPGS++C CP G+R G C D+DEC C RC N GSF C C G
Sbjct: 617 RGA-CKNLPGSFRCVCPAGFR--GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAG 673
Query: 192 FQLGPNNRSCVDVNECDMGAP-CEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSY 249
F+ C DV+EC P C RC N+ G+F C C G++ + G C D+DEC
Sbjct: 674 FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 733
Query: 250 SSYLCQYRCVNEPGRFSCH-CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308
CVN PG F C CP G+ L R C D+DEC SGA C C N G +R
Sbjct: 734 HLACPGQECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFR 792
Query: 309 ----------------CVDTNRCVEPYIQVSENRCL 328
C D N C+E CL
Sbjct: 793 CSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECL 828
Score = 164 bits (416), Expect = 1e-40
Identities = 119/340 (35%), Positives = 146/340 (42%), Gaps = 75/340 (22%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLP----RSAAVINDLH-- 92
C GY+ P C+DV+EC P C G C N G + C+ R +A D+
Sbjct: 589 CPAGYQAAPHGASCQDVDECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDEC 647
Query: 93 GEGPPPPVPP--------------------------------AQHPNPC----------- 109
+ PPP P A+ P PC
Sbjct: 648 AQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGS 707
Query: 110 -----PPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQC-TCPDGYRKIGPEC 162
P G++P+ S C DVDEC H P Q+C N PGS+QC TCP G+ C
Sbjct: 708 FQCVCPMGFQPNTAGSECEDVDECEN--HLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 765
Query: 163 VDIDECRYRY--C--QHRCVNLPGSFRCQCEPGFQLGPNNRS--CVDVNECDMGAPC--E 214
D+DEC C C N GSFRC C PG++ P+ R C DVNEC G C
Sbjct: 766 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPH 824
Query: 215 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGY 273
C N+ G+F C C GY G SC D+DECS LCQ C N G F C CP G+
Sbjct: 825 GECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED-LCQSGICTNTDGSFECICPPGH 883
Query: 274 QL---LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
+ LA+ C D+DEC +Q C N G YRCV
Sbjct: 884 RAGPDLAS--CLDVDECRERGPALCGSQRCENSPGSYRCV 921
Score = 164 bits (415), Expect = 1e-40
Identities = 106/326 (32%), Positives = 143/326 (43%), Gaps = 55/326 (16%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G++ + C DV+EC AC G+ +C+N G + C
Sbjct: 712 CPMGFQPNTAGSECEDVDECEN-HLACPGQ-ECVNSPGSFQC------------------ 751
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-- 156
CP G+ + C DVDEC+ C P C N GS++C+C GYR
Sbjct: 752 --------RTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP 802
Query: 157 --KIGPECVDIDECR---YRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
+ GP C D++EC + + C+N GSF C C PG++ GP SC+DV+EC
Sbjct: 803 SGRPGP-CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 861
Query: 212 PCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDEC-SYSSYLC-QYRCVNEPGRFSC- 267
C+ C N+ G+F C C G+ D SC D+DEC LC RC N PG + C
Sbjct: 862 LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 921
Query: 268 -HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY------- 319
C GY C D+DEC+ + AQ C N G YRC T C Y
Sbjct: 922 RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRC--TPACDPGYQPTPGGG 979
Query: 320 ---IQVSENRCLCPASNPLCREQPSS 342
+ NR C A + +C+ P S
Sbjct: 980 CQDVDECRNRSFCGA-HAVCQNLPGS 1004
Score = 158 bits (400), Expect = 8e-39
Identities = 109/294 (37%), Positives = 140/294 (47%), Gaps = 61/294 (20%)
Query: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
C DVNECL + C +C+N G + C C P
Sbjct: 809 CADVNECLE-GDFCFPHGECLNTDGSFACT---------------------------CAP 840
Query: 112 GYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE---CVDIDE 167
GY P + SC+DVDEC++ D S C N GS++C CP G+R GP+ C+D+DE
Sbjct: 841 GYRPGPRGASCLDVDECSE--EDLCQSGICTNTDGSFECICPPGHRA-GPDLASCLDVDE 897
Query: 168 CRYR---YC-QHRCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP--C-EQRCF 218
CR R C RC N PGS+RC C+PG+ GP +C DV+EC P C QRC
Sbjct: 898 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCE 956
Query: 219 NSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQ- 274
N+ G++ C C GY+ G C D+DEC S+ + C N PG F C C QGY+
Sbjct: 957 NTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1015
Query: 275 LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV----------DTNRCVEP 318
R C D++ECE+ C A C N G + CV T RCV P
Sbjct: 1016 ARDGRHCVDVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPP 1068
Score = 150 bits (379), Expect = 2e-36
Identities = 87/225 (38%), Positives = 114/225 (50%), Gaps = 13/225 (5%)
Query: 94 EGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
E P P P + P P P + P+ +S C + C P + C + P Y C C
Sbjct: 448 EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-CISRPSGYTCACD 506
Query: 153 DGYR--KIGPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
G+R G C+D+DECR RC N PGSFRC C PGF+ GP C+DV+EC
Sbjct: 507 SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 566
Query: 208 D-MGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ PC+ RC N+ G+FLC C GY+ G SC D+DEC+ S LC + C N PG
Sbjct: 567 HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGS 626
Query: 265 FSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
F C CP G++ A +D+DEC C + C N G + C
Sbjct: 627 FRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGSFHC 668
Score = 133 bits (335), Expect = 3e-31
Identities = 91/246 (36%), Positives = 113/246 (45%), Gaps = 45/246 (18%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY P C DV+EC + + C+ + C N G + C+
Sbjct: 838 CAPGYRPGPRGASCLDVDEC-SEEDLCQSGI-CTNTDGSFECI----------------- 878
Query: 99 PVPPAQHPNPCPPGYEPD-DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT--CPDGY 155
CPPG+ D SC+DVDEC + SQ C N PGSY+C C GY
Sbjct: 879 ----------CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 928
Query: 156 RKIGPE--CVDIDECRY---RYC-QHRCVNLPGSFRCQ--CEPGFQLGPNNRSCVDVNEC 207
GPE C D+DEC+ C RC N PGS+RC C+PG+Q P C DV+EC
Sbjct: 929 HA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDEC 986
Query: 208 DMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ C C N G+F C C QGYE RDG C D++EC +C C N G
Sbjct: 987 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1046
Query: 265 FSCHCP 270
F C CP
Sbjct: 1047 FLCVCP 1052
Score = 109 bits (273), Expect = 4e-24
Identities = 56/139 (40%), Positives = 69/139 (49%), Gaps = 5/139 (3%)
Query: 176 RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYE 233
RC++ P + C C+ GF+L P C+DV+EC + PC RC NS G+F C C G+
Sbjct: 493 RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFR 552
Query: 234 LHRDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQLLA-TRLCQDIDECESGA 291
C D+DEC C RC N PG F C CP GYQ CQD+DEC
Sbjct: 553 AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 612
Query: 292 HQCSEAQTCVNFHGGYRCV 310
C C N G +RCV
Sbjct: 613 GLCGRG-ACKNLPGSFRCV 630
Score = 83.6 bits (205), Expect = 3e-16
Identities = 103/406 (25%), Positives = 135/406 (33%), Gaps = 130/406 (32%)
Query: 21 LLGSASPQDSEEPDSYT---ECTDGYEWDPDSQHCRDVNECLTI-PEACKGEMKCINHYG 76
L GS ++S P SY +C GY P+ C DV+EC PE C G +C N G
Sbjct: 905 LCGSQRCENS--PGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGPEIC-GAQRCENTPG 960
Query: 77 GYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRP 136
Y C P C PGY+P C DVDEC C
Sbjct: 961 SYRCTPA-------------------------CDPGYQPTPGGGCQDVDECRNRSF-CGA 994
Query: 137 SQDCHNLPGSYQCTCPDGYR--KIGPECVDIDE-------CRYRYCQHR-------CVNL 180
C NLPGS+QC C GY + G CVD++E C C++ C N
Sbjct: 995 HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNS 1054
Query: 181 PGSF-----RCQCE-------PGFQ-----------------------------LGPNNR 199
P F RC PG Q +G R
Sbjct: 1055 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1114
Query: 200 SCVDVNECDMGAP--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR 257
C D AP C+ + C C G G C I +C +
Sbjct: 1115 ECY----FDTAAPDACDNILARNVTWQECCCTVGEGW---GSGCR-IQQCPGT------- 1159
Query: 258 CVNEPGRFSCHCPQGYQLLATR----LCQDIDECESGAHQCSEAQTCVNFHGGY------ 307
E + CP G LA L +D+DEC+ Q ++ CVN GY
Sbjct: 1160 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1216
Query: 308 ---------RCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIV 344
C+D + C + RC+ + C +P ++
Sbjct: 1217 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262
Score = 78.6 bits (192), Expect = 1e-14
Identities = 85/303 (28%), Positives = 109/303 (35%), Gaps = 40/303 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PRSAAVINDLHGEGPP 97
C GYE D +HC DVNEC T+ C G C N G +LC+ P S + + G P
Sbjct: 1009 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1067
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
P P G +P S V RPS GS + C +
Sbjct: 1068 PRTSAGTFP-----GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDT 1120
Query: 158 IGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRC 217
P+ D R Q C C G+ G + C + +
Sbjct: 1121 AAPDACDNILARNVTWQECC--------CTVGEGWGSGCRIQQCPGTETAEYQS------ 1166
Query: 218 FNSYGTFLCRCHQGYELHRDGFSCS-DIDECS-YSSYLCQYR-CVNEPGRFSCHCPQGYQ 274
LC +GY S D+DEC + +C+ CVN +SC+C GY
Sbjct: 1167 -------LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1219
Query: 275 LLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI-QVSENRCLCPAS 332
RL C D DEC C E CVN G Y C C P + S+ RC+ S
Sbjct: 1220 YHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHCT----CEPPLVLDGSQRRCVSNES 1274
Query: 333 NPL 335
L
Sbjct: 1275 QSL 1277
Score = 61.6 bits (148), Expect = 1e-09
Identities = 32/94 (34%), Positives = 46/94 (48%), Gaps = 10/94 (10%)
Query: 145 GSYQCTCPDGYRKI-GPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVD 203
GSY + + Y ++ EC +D C RCV +P F C+C G++L +CVD
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCT----NGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507
Query: 204 VNECDMGAPC-----EQRCFNSYGTFLCRCHQGY 232
+NECD RC N+ G+F C C G+
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/107 (32%), Positives = 43/107 (40%), Gaps = 18/107 (16%)
Query: 96 PPPPVPP--AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPD 153
P P PP + YE + + C +D C C +P + C C D
Sbjct: 1443 PEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGR--------CVRVPEGFTCRCFD 1494
Query: 154 GYR--KIGPECVDIDECRYRYC------QHRCVNLPGSFRCQCEPGF 192
GYR CVDI+EC RC+N GSFRC C PGF
Sbjct: 1495 GYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 11/93 (11%)
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT------CPDGYRKIGPECVDIDECRY- 170
Q+ C A +HDC Q C G+ + CP G+ ++ C D+DEC
Sbjct: 241 QEVCCRGAGLAWGVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATG 297
Query: 171 RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCV 202
CQH C N G + C C GF L + SC+
Sbjct: 298 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 330
Score = 50.4 bits (119), Expect = 3e-06
Identities = 27/72 (37%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 243 DIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDEC---ESGAHQCSEAQ 298
+ +EC RCV P F+C C GY+L TR+ C DI+EC E+ + C A+
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 299 TCVNFHGGYRCV 310
C+N G +RC+
Sbjct: 1526 -CLNTDGSFRCI 1536
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 202 VDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLC-QY 256
++ EC + C RC F CRC GY L +C DI+EC +S LC
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524
Query: 257 RCVNEPGRFSCHCPQGY 273
RC+N G F C C G+
Sbjct: 1525 RCLNTDGSFRCICRPGF 1541
Score = 45.8 bits (107), Expect = 8e-05
Identities = 23/48 (47%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 108 PCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
PCP G+E + SC DVDECA C+ + C N G Y C CPDG+
Sbjct: 276 PCPTGFERVN-GSCEDVDECATGGR-CQHGE-CANTRGGYTCVCPDGF 320
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 21/130 (16%)
Query: 204 VNECDMGAPCEQRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNE 261
V++C + C +R NS C G+E R SC D+DEC+ C N
Sbjct: 254 VHDCQL---CSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGECANT 308
Query: 262 PGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQ-TCVNFHGGYRCVDTNRCVEPYI 320
G ++C CP G+ L ++R C S H SEA+ C +R + C P +
Sbjct: 309 RGGYTCVCPDGFLLDSSR-----SSCIS-QHVISEAKGPC------FRVLRDGGCSLPIL 356
Query: 321 Q-VSENRCLC 329
+ +++ C C
Sbjct: 357 RNITKQICCC 366
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSC 241
C GF+ N SC DV+EC G C+ C N+ G + C C G+ L SC
Sbjct: 277 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 35.8 bits (81), Expect = 0.080
Identities = 23/82 (28%), Positives = 31/82 (37%), Gaps = 17/82 (20%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACK--GEMKCINHYGGYLCLPRSAAVIN 89
P+ +T C DGY D C D+NEC A +C+N G + C+ R
Sbjct: 1485 PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR------ 1538
Query: 90 DLHGEGPPPPVPPAQHPNPCPP 111
P P P+ C P
Sbjct: 1539 --------PGFAPTHQPHHCAP 1552
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 180 bits (457), Expect = 2e-45
Identities = 118/336 (35%), Positives = 146/336 (43%), Gaps = 45/336 (13%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL--------PR 83
P YT C G+ P C DV+EC +P C +C N G + C+ PR
Sbjct: 528 PSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPR 586
Query: 84 SAAVINDLHGEGPPPPVPPAQHPNP-------CPPGYEPDDQD-SCVDVDECAQALHDCR 135
+A ++ PPP + N CP GY+ SC DVDEC Q+ C
Sbjct: 587 AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 646
Query: 136 PSQDCHNLPGSYQCTCPDGYRKIGPECV-DIDECRYRY--C-QHRCVNLPGSFRCQCEPG 191
C NLPGS++C CP G+R G C D+DEC C RC N GSF C C G
Sbjct: 647 RGA-CKNLPGSFRCVCPAGFR--GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAG 703
Query: 192 FQLGPNNRSCVDVNECDMGAP-CEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSY 249
F+ C DV+EC P C RC N+ G+F C C G++ + G C D+DEC
Sbjct: 704 FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 763
Query: 250 SSYLCQYRCVNEPGRFSCH-CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308
CVN PG F C CP G+ L R C D+DEC SGA C C N G +R
Sbjct: 764 HLACPGQECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFR 822
Query: 309 ----------------CVDTNRCVEPYIQVSENRCL 328
C D N C+E CL
Sbjct: 823 CSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECL 858
Score = 164 bits (416), Expect = 1e-40
Identities = 119/340 (35%), Positives = 146/340 (42%), Gaps = 75/340 (22%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLP----RSAAVINDLH-- 92
C GY+ P C+DV+EC P C G C N G + C+ R +A D+
Sbjct: 619 CPAGYQAAPHGASCQDVDECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDEC 677
Query: 93 GEGPPPPVPP--------------------------------AQHPNPC----------- 109
+ PPP P A+ P PC
Sbjct: 678 AQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGS 737
Query: 110 -----PPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQC-TCPDGYRKIGPEC 162
P G++P+ S C DVDEC H P Q+C N PGS+QC TCP G+ C
Sbjct: 738 FQCVCPMGFQPNTAGSECEDVDECEN--HLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 795
Query: 163 VDIDECRYRY--C--QHRCVNLPGSFRCQCEPGFQLGPNNRS--CVDVNECDMGAPC--E 214
D+DEC C C N GSFRC C PG++ P+ R C DVNEC G C
Sbjct: 796 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPH 854
Query: 215 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGY 273
C N+ G+F C C GY G SC D+DECS LCQ C N G F C CP G+
Sbjct: 855 GECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED-LCQSGICTNTDGSFECICPPGH 913
Query: 274 QL---LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
+ LA+ C D+DEC +Q C N G YRCV
Sbjct: 914 RAGPDLAS--CLDVDECRERGPALCGSQRCENSPGSYRCV 951
Score = 164 bits (415), Expect = 1e-40
Identities = 106/326 (32%), Positives = 143/326 (43%), Gaps = 55/326 (16%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G++ + C DV+EC AC G+ +C+N G + C
Sbjct: 742 CPMGFQPNTAGSECEDVDECEN-HLACPGQ-ECVNSPGSFQC------------------ 781
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-- 156
CP G+ + C DVDEC+ C P C N GS++C+C GYR
Sbjct: 782 --------RTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP 832
Query: 157 --KIGPECVDIDECR---YRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
+ GP C D++EC + + C+N GSF C C PG++ GP SC+DV+EC
Sbjct: 833 SGRPGP-CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 891
Query: 212 PCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDEC-SYSSYLC-QYRCVNEPGRFSC- 267
C+ C N+ G+F C C G+ D SC D+DEC LC RC N PG + C
Sbjct: 892 LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 951
Query: 268 -HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY------- 319
C GY C D+DEC+ + AQ C N G YRC T C Y
Sbjct: 952 RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRC--TPACDPGYQPTPGGG 1009
Query: 320 ---IQVSENRCLCPASNPLCREQPSS 342
+ NR C A + +C+ P S
Sbjct: 1010 CQDVDECRNRSFCGA-HAVCQNLPGS 1034
Score = 158 bits (400), Expect = 8e-39
Identities = 109/294 (37%), Positives = 140/294 (47%), Gaps = 61/294 (20%)
Query: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
C DVNECL + C +C+N G + C C P
Sbjct: 839 CADVNECLE-GDFCFPHGECLNTDGSFACT---------------------------CAP 870
Query: 112 GYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE---CVDIDE 167
GY P + SC+DVDEC++ D S C N GS++C CP G+R GP+ C+D+DE
Sbjct: 871 GYRPGPRGASCLDVDECSE--EDLCQSGICTNTDGSFECICPPGHRA-GPDLASCLDVDE 927
Query: 168 CRYR---YC-QHRCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP--C-EQRCF 218
CR R C RC N PGS+RC C+PG+ GP +C DV+EC P C QRC
Sbjct: 928 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCE 986
Query: 219 NSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQ- 274
N+ G++ C C GY+ G C D+DEC S+ + C N PG F C C QGY+
Sbjct: 987 NTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1045
Query: 275 LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV----------DTNRCVEP 318
R C D++ECE+ C A C N G + CV T RCV P
Sbjct: 1046 ARDGRHCVDVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPP 1098
Score = 150 bits (379), Expect = 2e-36
Identities = 87/225 (38%), Positives = 114/225 (50%), Gaps = 13/225 (5%)
Query: 94 EGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
E P P P + P P P + P+ +S C + C P + C + P Y C C
Sbjct: 478 EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-CISRPSGYTCACD 536
Query: 153 DGYR--KIGPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
G+R G C+D+DECR RC N PGSFRC C PGF+ GP C+DV+EC
Sbjct: 537 SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 596
Query: 208 D-MGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ PC+ RC N+ G+FLC C GY+ G SC D+DEC+ S LC + C N PG
Sbjct: 597 HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGS 656
Query: 265 FSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
F C CP G++ A +D+DEC C + C N G + C
Sbjct: 657 FRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGSFHC 698
Score = 133 bits (335), Expect = 3e-31
Identities = 91/246 (36%), Positives = 113/246 (45%), Gaps = 45/246 (18%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY P C DV+EC + + C+ + C N G + C+
Sbjct: 868 CAPGYRPGPRGASCLDVDEC-SEEDLCQSGI-CTNTDGSFECI----------------- 908
Query: 99 PVPPAQHPNPCPPGYEPD-DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT--CPDGY 155
CPPG+ D SC+DVDEC + SQ C N PGSY+C C GY
Sbjct: 909 ----------CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 958
Query: 156 RKIGPE--CVDIDECRY---RYC-QHRCVNLPGSFRCQ--CEPGFQLGPNNRSCVDVNEC 207
GPE C D+DEC+ C RC N PGS+RC C+PG+Q P C DV+EC
Sbjct: 959 HA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDEC 1016
Query: 208 DMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ C C N G+F C C QGYE RDG C D++EC +C C N G
Sbjct: 1017 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1076
Query: 265 FSCHCP 270
F C CP
Sbjct: 1077 FLCVCP 1082
Score = 109 bits (273), Expect = 4e-24
Identities = 56/139 (40%), Positives = 69/139 (49%), Gaps = 5/139 (3%)
Query: 176 RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYE 233
RC++ P + C C+ GF+L P C+DV+EC + PC RC NS G+F C C G+
Sbjct: 523 RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFR 582
Query: 234 LHRDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQLLA-TRLCQDIDECESGA 291
C D+DEC C RC N PG F C CP GYQ CQD+DEC
Sbjct: 583 AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 642
Query: 292 HQCSEAQTCVNFHGGYRCV 310
C C N G +RCV
Sbjct: 643 GLCGRG-ACKNLPGSFRCV 660
Score = 83.6 bits (205), Expect = 3e-16
Identities = 103/406 (25%), Positives = 135/406 (33%), Gaps = 130/406 (32%)
Query: 21 LLGSASPQDSEEPDSYT---ECTDGYEWDPDSQHCRDVNECLTI-PEACKGEMKCINHYG 76
L GS ++S P SY +C GY P+ C DV+EC PE C G +C N G
Sbjct: 935 LCGSQRCENS--PGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGPEIC-GAQRCENTPG 990
Query: 77 GYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRP 136
Y C P C PGY+P C DVDEC C
Sbjct: 991 SYRCTPA-------------------------CDPGYQPTPGGGCQDVDECRNRSF-CGA 1024
Query: 137 SQDCHNLPGSYQCTCPDGYR--KIGPECVDIDE-------CRYRYCQHR-------CVNL 180
C NLPGS+QC C GY + G CVD++E C C++ C N
Sbjct: 1025 HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNS 1084
Query: 181 PGSF-----RCQCE-------PGFQ-----------------------------LGPNNR 199
P F RC PG Q +G R
Sbjct: 1085 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1144
Query: 200 SCVDVNECDMGAP--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR 257
C D AP C+ + C C G G C I +C +
Sbjct: 1145 ECY----FDTAAPDACDNILARNVTWQECCCTVGEGW---GSGCR-IQQCPGT------- 1189
Query: 258 CVNEPGRFSCHCPQGYQLLATR----LCQDIDECESGAHQCSEAQTCVNFHGGY------ 307
E + CP G LA L +D+DEC+ Q ++ CVN GY
Sbjct: 1190 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1246
Query: 308 ---------RCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIV 344
C+D + C + RC+ + C +P ++
Sbjct: 1247 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292
Score = 78.6 bits (192), Expect = 1e-14
Identities = 85/303 (28%), Positives = 109/303 (35%), Gaps = 40/303 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PRSAAVINDLHGEGPP 97
C GYE D +HC DVNEC T+ C G C N G +LC+ P S + + G P
Sbjct: 1039 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1097
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
P P G +P S V RPS GS + C +
Sbjct: 1098 PRTSAGTFP-----GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDT 1150
Query: 158 IGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRC 217
P+ D R Q C C G+ G + C + +
Sbjct: 1151 AAPDACDNILARNVTWQECC--------CTVGEGWGSGCRIQQCPGTETAEYQS------ 1196
Query: 218 FNSYGTFLCRCHQGYELHRDGFSCS-DIDECS-YSSYLCQYR-CVNEPGRFSCHCPQGYQ 274
LC +GY S D+DEC + +C+ CVN +SC+C GY
Sbjct: 1197 -------LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1249
Query: 275 LLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI-QVSENRCLCPAS 332
RL C D DEC C E CVN G Y C C P + S+ RC+ S
Sbjct: 1250 YHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHCT----CEPPLVLDGSQRRCVSNES 1304
Query: 333 NPL 335
L
Sbjct: 1305 QSL 1307
Score = 61.6 bits (148), Expect = 1e-09
Identities = 32/94 (34%), Positives = 46/94 (48%), Gaps = 10/94 (10%)
Query: 145 GSYQCTCPDGYRKI-GPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVD 203
GSY + + Y ++ EC +D C RCV +P F C+C G++L +CVD
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCT----NGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537
Query: 204 VNECDMGAPC-----EQRCFNSYGTFLCRCHQGY 232
+NECD RC N+ G+F C C G+
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/107 (32%), Positives = 43/107 (40%), Gaps = 18/107 (16%)
Query: 96 PPPPVPP--AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPD 153
P P PP + YE + + C +D C C +P + C C D
Sbjct: 1473 PEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGR--------CVRVPEGFTCRCFD 1524
Query: 154 GYR--KIGPECVDIDECRYRYC------QHRCVNLPGSFRCQCEPGF 192
GYR CVDI+EC RC+N GSFRC C PGF
Sbjct: 1525 GYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 11/93 (11%)
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT------CPDGYRKIGPECVDIDECRY- 170
Q+ C A +HDC Q C G+ + CP G+ ++ C D+DEC
Sbjct: 271 QEVCCRGAGLAWGVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATG 327
Query: 171 RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCV 202
CQH C N G + C C GF L + SC+
Sbjct: 328 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 360
Score = 50.4 bits (119), Expect = 3e-06
Identities = 27/72 (37%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 243 DIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDEC---ESGAHQCSEAQ 298
+ +EC RCV P F+C C GY+L TR+ C DI+EC E+ + C A+
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 299 TCVNFHGGYRCV 310
C+N G +RC+
Sbjct: 1556 -CLNTDGSFRCI 1566
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 202 VDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLC-QY 256
++ EC + C RC F CRC GY L +C DI+EC +S LC
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554
Query: 257 RCVNEPGRFSCHCPQGY 273
RC+N G F C C G+
Sbjct: 1555 RCLNTDGSFRCICRPGF 1571
Score = 45.8 bits (107), Expect = 8e-05
Identities = 23/48 (47%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 108 PCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
PCP G+E + SC DVDECA C+ + C N G Y C CPDG+
Sbjct: 306 PCPTGFERVN-GSCEDVDECATGGR-CQHGE-CANTRGGYTCVCPDGF 350
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 21/130 (16%)
Query: 204 VNECDMGAPCEQRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNE 261
V++C + C +R NS C G+E R SC D+DEC+ C N
Sbjct: 284 VHDCQL---CSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGECANT 338
Query: 262 PGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQ-TCVNFHGGYRCVDTNRCVEPYI 320
G ++C CP G+ L ++R C S H SEA+ C +R + C P +
Sbjct: 339 RGGYTCVCPDGFLLDSSR-----SSCIS-QHVISEAKGPC------FRVLRDGGCSLPIL 386
Query: 321 Q-VSENRCLC 329
+ +++ C C
Sbjct: 387 RNITKQICCC 396
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSC 241
C GF+ N SC DV+EC G C+ C N+ G + C C G+ L SC
Sbjct: 307 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 35.8 bits (81), Expect = 0.080
Identities = 23/82 (28%), Positives = 31/82 (37%), Gaps = 17/82 (20%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACK--GEMKCINHYGGYLCLPRSAAVIN 89
P+ +T C DGY D C D+NEC A +C+N G + C+ R
Sbjct: 1515 PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR------ 1568
Query: 90 DLHGEGPPPPVPPAQHPNPCPP 111
P P P+ C P
Sbjct: 1569 --------PGFAPTHQPHHCAP 1582
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 180 bits (457), Expect = 2e-45
Identities = 118/336 (35%), Positives = 146/336 (43%), Gaps = 45/336 (13%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL--------PR 83
P YT C G+ P C DV+EC +P C +C N G + C+ PR
Sbjct: 565 PSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPR 623
Query: 84 SAAVINDLHGEGPPPPVPPAQHPNP-------CPPGYEPDDQD-SCVDVDECAQALHDCR 135
+A ++ PPP + N CP GY+ SC DVDEC Q+ C
Sbjct: 624 AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 683
Query: 136 PSQDCHNLPGSYQCTCPDGYRKIGPECV-DIDECRYRY--C-QHRCVNLPGSFRCQCEPG 191
C NLPGS++C CP G+R G C D+DEC C RC N GSF C C G
Sbjct: 684 RGA-CKNLPGSFRCVCPAGFR--GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAG 740
Query: 192 FQLGPNNRSCVDVNECDMGAP-CEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSY 249
F+ C DV+EC P C RC N+ G+F C C G++ + G C D+DEC
Sbjct: 741 FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 800
Query: 250 SSYLCQYRCVNEPGRFSCH-CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYR 308
CVN PG F C CP G+ L R C D+DEC SGA C C N G +R
Sbjct: 801 HLACPGQECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFR 859
Query: 309 ----------------CVDTNRCVEPYIQVSENRCL 328
C D N C+E CL
Sbjct: 860 CSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECL 895
Score = 164 bits (416), Expect = 1e-40
Identities = 119/340 (35%), Positives = 146/340 (42%), Gaps = 75/340 (22%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLP----RSAAVINDLH-- 92
C GY+ P C+DV+EC P C G C N G + C+ R +A D+
Sbjct: 656 CPAGYQAAPHGASCQDVDECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDEC 714
Query: 93 GEGPPPPVPP--------------------------------AQHPNPC----------- 109
+ PPP P A+ P PC
Sbjct: 715 AQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGS 774
Query: 110 -----PPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQC-TCPDGYRKIGPEC 162
P G++P+ S C DVDEC H P Q+C N PGS+QC TCP G+ C
Sbjct: 775 FQCVCPMGFQPNTAGSECEDVDECEN--HLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 832
Query: 163 VDIDECRYRY--C--QHRCVNLPGSFRCQCEPGFQLGPNNRS--CVDVNECDMGAPC--E 214
D+DEC C C N GSFRC C PG++ P+ R C DVNEC G C
Sbjct: 833 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPH 891
Query: 215 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGY 273
C N+ G+F C C GY G SC D+DECS LCQ C N G F C CP G+
Sbjct: 892 GECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED-LCQSGICTNTDGSFECICPPGH 950
Query: 274 QL---LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
+ LA+ C D+DEC +Q C N G YRCV
Sbjct: 951 RAGPDLAS--CLDVDECRERGPALCGSQRCENSPGSYRCV 988
Score = 164 bits (415), Expect = 1e-40
Identities = 106/326 (32%), Positives = 143/326 (43%), Gaps = 55/326 (16%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G++ + C DV+EC AC G+ +C+N G + C
Sbjct: 779 CPMGFQPNTAGSECEDVDECEN-HLACPGQ-ECVNSPGSFQC------------------ 818
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-- 156
CP G+ + C DVDEC+ C P C N GS++C+C GYR
Sbjct: 819 --------RTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP 869
Query: 157 --KIGPECVDIDECR---YRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
+ GP C D++EC + + C+N GSF C C PG++ GP SC+DV+EC
Sbjct: 870 SGRPGP-CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 928
Query: 212 PCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDEC-SYSSYLC-QYRCVNEPGRFSC- 267
C+ C N+ G+F C C G+ D SC D+DEC LC RC N PG + C
Sbjct: 929 LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 988
Query: 268 -HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY------- 319
C GY C D+DEC+ + AQ C N G YRC T C Y
Sbjct: 989 RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRC--TPACDPGYQPTPGGG 1046
Query: 320 ---IQVSENRCLCPASNPLCREQPSS 342
+ NR C A + +C+ P S
Sbjct: 1047 CQDVDECRNRSFCGA-HAVCQNLPGS 1071
Score = 158 bits (400), Expect = 8e-39
Identities = 109/294 (37%), Positives = 140/294 (47%), Gaps = 61/294 (20%)
Query: 52 CRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPP 111
C DVNECL + C +C+N G + C C P
Sbjct: 876 CADVNECLE-GDFCFPHGECLNTDGSFACT---------------------------CAP 907
Query: 112 GYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE---CVDIDE 167
GY P + SC+DVDEC++ D S C N GS++C CP G+R GP+ C+D+DE
Sbjct: 908 GYRPGPRGASCLDVDECSE--EDLCQSGICTNTDGSFECICPPGHRA-GPDLASCLDVDE 964
Query: 168 CRYR---YC-QHRCVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAP--C-EQRCF 218
CR R C RC N PGS+RC C+PG+ GP +C DV+EC P C QRC
Sbjct: 965 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCE 1023
Query: 219 NSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQ- 274
N+ G++ C C GY+ G C D+DEC S+ + C N PG F C C QGY+
Sbjct: 1024 NTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1082
Query: 275 LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV----------DTNRCVEP 318
R C D++ECE+ C A C N G + CV T RCV P
Sbjct: 1083 ARDGRHCVDVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPP 1135
Score = 150 bits (379), Expect = 2e-36
Identities = 87/225 (38%), Positives = 114/225 (50%), Gaps = 13/225 (5%)
Query: 94 EGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
E P P P + P P P + P+ +S C + C P + C + P Y C C
Sbjct: 515 EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-CISRPSGYTCACD 573
Query: 153 DGYR--KIGPECVDIDECRY---RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
G+R G C+D+DECR RC N PGSFRC C PGF+ GP C+DV+EC
Sbjct: 574 SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 633
Query: 208 D-MGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ PC+ RC N+ G+FLC C GY+ G SC D+DEC+ S LC + C N PG
Sbjct: 634 HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGS 693
Query: 265 FSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
F C CP G++ A +D+DEC C + C N G + C
Sbjct: 694 FRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGSFHC 735
Score = 133 bits (335), Expect = 3e-31
Identities = 91/246 (36%), Positives = 113/246 (45%), Gaps = 45/246 (18%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY P C DV+EC + + C+ + C N G + C+
Sbjct: 905 CAPGYRPGPRGASCLDVDEC-SEEDLCQSGI-CTNTDGSFECI----------------- 945
Query: 99 PVPPAQHPNPCPPGYEPD-DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT--CPDGY 155
CPPG+ D SC+DVDEC + SQ C N PGSY+C C GY
Sbjct: 946 ----------CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 995
Query: 156 RKIGPE--CVDIDECRY---RYC-QHRCVNLPGSFRCQ--CEPGFQLGPNNRSCVDVNEC 207
GPE C D+DEC+ C RC N PGS+RC C+PG+Q P C DV+EC
Sbjct: 996 HA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDEC 1053
Query: 208 DMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
+ C C N G+F C C QGYE RDG C D++EC +C C N G
Sbjct: 1054 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1113
Query: 265 FSCHCP 270
F C CP
Sbjct: 1114 FLCVCP 1119
Score = 109 bits (273), Expect = 4e-24
Identities = 56/139 (40%), Positives = 69/139 (49%), Gaps = 5/139 (3%)
Query: 176 RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYE 233
RC++ P + C C+ GF+L P C+DV+EC + PC RC NS G+F C C G+
Sbjct: 560 RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFR 619
Query: 234 LHRDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQLLA-TRLCQDIDECESGA 291
C D+DEC C RC N PG F C CP GYQ CQD+DEC
Sbjct: 620 AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 679
Query: 292 HQCSEAQTCVNFHGGYRCV 310
C C N G +RCV
Sbjct: 680 GLCGRG-ACKNLPGSFRCV 697
Score = 83.6 bits (205), Expect = 3e-16
Identities = 103/406 (25%), Positives = 135/406 (33%), Gaps = 130/406 (32%)
Query: 21 LLGSASPQDSEEPDSYT---ECTDGYEWDPDSQHCRDVNECLTI-PEACKGEMKCINHYG 76
L GS ++S P SY +C GY P+ C DV+EC PE C G +C N G
Sbjct: 972 LCGSQRCENS--PGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGPEIC-GAQRCENTPG 1027
Query: 77 GYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRP 136
Y C P C PGY+P C DVDEC C
Sbjct: 1028 SYRCTPA-------------------------CDPGYQPTPGGGCQDVDECRNRSF-CGA 1061
Query: 137 SQDCHNLPGSYQCTCPDGYR--KIGPECVDIDE-------CRYRYCQHR-------CVNL 180
C NLPGS+QC C GY + G CVD++E C C++ C N
Sbjct: 1062 HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNS 1121
Query: 181 PGSF-----RCQCE-------PGFQ-----------------------------LGPNNR 199
P F RC PG Q +G R
Sbjct: 1122 PEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRR 1181
Query: 200 SCVDVNECDMGAP--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR 257
C D AP C+ + C C G G C I +C +
Sbjct: 1182 ECY----FDTAAPDACDNILARNVTWQECCCTVGEGW---GSGCR-IQQCPGT------- 1226
Query: 258 CVNEPGRFSCHCPQGYQLLATR----LCQDIDECESGAHQCSEAQTCVNFHGGY------ 307
E + CP G LA L +D+DEC+ Q ++ CVN GY
Sbjct: 1227 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1283
Query: 308 ---------RCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIV 344
C+D + C + RC+ + C +P ++
Sbjct: 1284 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329
Score = 78.6 bits (192), Expect = 1e-14
Identities = 85/303 (28%), Positives = 109/303 (35%), Gaps = 40/303 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PRSAAVINDLHGEGPP 97
C GYE D +HC DVNEC T+ C G C N G +LC+ P S + + G P
Sbjct: 1076 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1134
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
P P G +P S V RPS GS + C +
Sbjct: 1135 PRTSAGTFP-----GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDT 1187
Query: 158 IGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRC 217
P+ D R Q C C G+ G + C + +
Sbjct: 1188 AAPDACDNILARNVTWQECC--------CTVGEGWGSGCRIQQCPGTETAEYQS------ 1233
Query: 218 FNSYGTFLCRCHQGYELHRDGFSCS-DIDECS-YSSYLCQYR-CVNEPGRFSCHCPQGYQ 274
LC +GY S D+DEC + +C+ CVN +SC+C GY
Sbjct: 1234 -------LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY 1286
Query: 275 LLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI-QVSENRCLCPAS 332
RL C D DEC C E CVN G Y C C P + S+ RC+ S
Sbjct: 1287 YHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHCT----CEPPLVLDGSQRRCVSNES 1341
Query: 333 NPL 335
L
Sbjct: 1342 QSL 1344
Score = 61.6 bits (148), Expect = 1e-09
Identities = 32/94 (34%), Positives = 46/94 (48%), Gaps = 10/94 (10%)
Query: 145 GSYQCTCPDGYRKI-GPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVD 203
GSY + + Y ++ EC +D C RCV +P F C+C G++L +CVD
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCT----NGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574
Query: 204 VNECDMGAPC-----EQRCFNSYGTFLCRCHQGY 232
+NECD RC N+ G+F C C G+
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/107 (32%), Positives = 43/107 (40%), Gaps = 18/107 (16%)
Query: 96 PPPPVPP--AQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPD 153
P P PP + YE + + C +D C C +P + C C D
Sbjct: 1510 PEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGR--------CVRVPEGFTCRCFD 1561
Query: 154 GYR--KIGPECVDIDECRYRYC------QHRCVNLPGSFRCQCEPGF 192
GYR CVDI+EC RC+N GSFRC C PGF
Sbjct: 1562 GYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 11/93 (11%)
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT------CPDGYRKIGPECVDIDECRY- 170
Q+ C A +HDC Q C G+ + CP G+ ++ C D+DEC
Sbjct: 308 QEVCCRGAGLAWGVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATG 364
Query: 171 RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCV 202
CQH C N G + C C GF L + SC+
Sbjct: 365 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 397
Score = 50.4 bits (119), Expect = 3e-06
Identities = 27/72 (37%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 243 DIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDEC---ESGAHQCSEAQ 298
+ +EC RCV P F+C C GY+L TR+ C DI+EC E+ + C A+
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 299 TCVNFHGGYRCV 310
C+N G +RC+
Sbjct: 1593 -CLNTDGSFRCI 1603
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 202 VDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYSSYLC-QY 256
++ EC + C RC F CRC GY L +C DI+EC +S LC
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591
Query: 257 RCVNEPGRFSCHCPQGY 273
RC+N G F C C G+
Sbjct: 1592 RCLNTDGSFRCICRPGF 1608
Score = 45.8 bits (107), Expect = 8e-05
Identities = 23/48 (47%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 108 PCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
PCP G+E + SC DVDECA C+ + C N G Y C CPDG+
Sbjct: 343 PCPTGFERVN-GSCEDVDECATGGR-CQHGE-CANTRGGYTCVCPDGF 387
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 21/130 (16%)
Query: 204 VNECDMGAPCEQRCFNSYGTFLCR--CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNE 261
V++C + C +R NS C G+E R SC D+DEC+ C N
Sbjct: 321 VHDCQL---CSERLGNSERVSAPDGPCPTGFE--RVNGSCEDVDECATGGRCQHGECANT 375
Query: 262 PGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQ-TCVNFHGGYRCVDTNRCVEPYI 320
G ++C CP G+ L ++R C S H SEA+ C +R + C P +
Sbjct: 376 RGGYTCVCPDGFLLDSSR-----SSCIS-QHVISEAKGPC------FRVLRDGGCSLPIL 423
Query: 321 Q-VSENRCLC 329
+ +++ C C
Sbjct: 424 RNITKQICCC 433
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Query: 188 CEPGFQLGPNNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSC 241
C GF+ N SC DV+EC G C+ C N+ G + C C G+ L SC
Sbjct: 344 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 35.8 bits (81), Expect = 0.080
Identities = 23/82 (28%), Positives = 31/82 (37%), Gaps = 17/82 (20%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACK--GEMKCINHYGGYLCLPRSAAVIN 89
P+ +T C DGY D C D+NEC A +C+N G + C+ R
Sbjct: 1552 PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR------ 1605
Query: 90 DLHGEGPPPPVPPAQHPNPCPP 111
P P P+ C P
Sbjct: 1606 --------PGFAPTHQPHHCAP 1619
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 177 bits (449), Expect = 2e-44
Identities = 100/286 (34%), Positives = 138/286 (48%), Gaps = 39/286 (13%)
Query: 34 DSYTECTDGYEWD-PDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLH 92
D +C +GYE ++C D++EC P C+G + C N G Y C
Sbjct: 1092 DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGV-CHNTEGSYRC------------ 1138
Query: 93 GEGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
CPPG++ + +C+D++EC + H C P+ C NL G YQC C
Sbjct: 1139 ---------------ECPPGHQLSPNISACIDINECELSAHLC-PNGRCVNLIGKYQCAC 1182
Query: 152 PDGYRKIGPE--CVDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
GY CVDIDEC C+ C N GS+ C C+PGF L P+ RSC D++EC
Sbjct: 1183 NPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDEC 1242
Query: 208 -DMGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGR 264
D C+ +C N G + C C+ G+ D +C D++EC + +C C N G
Sbjct: 1243 EDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGS 1302
Query: 265 FSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRC 309
F CHC GY + C DI+ECE GAH C + C N G ++C
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC 1348
Score = 172 bits (435), Expect = 7e-43
Identities = 106/323 (32%), Positives = 142/323 (43%), Gaps = 57/323 (17%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
EC G++ P+ C D+NEC C +C+N G Y C
Sbjct: 1139 ECPPGHQLSPNISACIDINECELSAHLCPNG-RCVNLIGKYQC----------------- 1180
Query: 98 PPVPPAQHPNPCPPGY-EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
C PGY D+ CVD+DEC+ C C N GSY+C+C G+
Sbjct: 1181 ----------ACNPGYHSTPDRLFCVDIDECSIMNGGCETF--CTNSEGSYECSCQPGFA 1228
Query: 157 KIGPE--CVDIDEC--RYRYCQ-HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
+ + C DIDEC C +C N+PG +RC C GF + ++CVDVNECD+
Sbjct: 1229 LMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNP 1288
Query: 212 P--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR--CVNEPGRFSC 267
C N+ G+F+C C GY + C+DI+EC ++ C C N G F C
Sbjct: 1289 NICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC 1348
Query: 268 HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI------- 320
C G+ + C D+DEC +G H CS+ C N G YRC+ C E Y
Sbjct: 1349 SCSPGWIGDGIK-CTDLDECSNGTHMCSQHADCKNTMGSYRCL----CKEGYTGDGFTCT 1403
Query: 321 ---QVSENRCLCPASNPLCREQP 340
+ SEN LC N C P
Sbjct: 1404 DLDECSENLNLC--GNGQCLNAP 1424
Score = 171 bits (434), Expect = 9e-43
Identities = 96/268 (35%), Positives = 127/268 (47%), Gaps = 40/268 (14%)
Query: 53 RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPG 112
+D+NEC IP C KC N G + C C G
Sbjct: 1027 KDINECKMIPSLCT-HGKCRNTIGSFKC---------------------------RCDSG 1058
Query: 113 YEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK---IGPECVDIDEC 168
+ D ++ +C D+DEC + C Q C N PG ++C C +GY + C+DIDEC
Sbjct: 1059 FALDSEERNCTDIDECRISPDLCGRGQ-CVNTPGDFECKCDEGYESGFMMMKNCMDIDEC 1117
Query: 169 RYRYCQHR---CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC--EQRCFNSYGT 223
+ R C N GS+RC+C PG QL PN +C+D+NEC++ A RC N G
Sbjct: 1118 QRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGK 1177
Query: 224 FLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLA-TRLCQ 282
+ C C+ GY D C DIDECS + C+ C N G + C C G+ L+ R C
Sbjct: 1178 YQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCT 1237
Query: 283 DIDECESGAHQCSEAQTCVNFHGGYRCV 310
DIDECE + C Q C N G YRC+
Sbjct: 1238 DIDECEDNPNICDGGQ-CTNIPGEYRCL 1264
Score = 163 bits (412), Expect = 3e-40
Identities = 101/297 (34%), Positives = 131/297 (44%), Gaps = 45/297 (15%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY D C D+NEC P+ C C N G Y C
Sbjct: 2429 CKTGYTPDITGTSCVDLNECNQAPKPCN--FICKNTEGSYQC------------------ 2468
Query: 99 PVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
CP GY +D SC D+DECA H+C+ C N G + C CP G+ +
Sbjct: 2469 ---------SCPKGYILQEDGRSCKDLDECATKQHNCQFL--CVNTIGGFTCKCPPGFTQ 2517
Query: 158 IGPECVDIDECR--YRYCQHR--CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC 213
C+D +EC C + C N PGSF C+C+ GF L SC DV+EC+ C
Sbjct: 2518 HHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRC 2577
Query: 214 EQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGRFSCHCPQG 272
+ C N G + C C QGY H C D +EC S+++C C N G + C CP G
Sbjct: 2578 QHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENEC-LSAHICGGASCHNTLGSYKCMCPAG 2636
Query: 273 YQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL 328
+Q + CQDI+EC S CS C N GGY C C Y ++ + C+
Sbjct: 2637 FQYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLC----GCPPGYFRIGQGHCV 2687
Score = 159 bits (403), Expect = 4e-39
Identities = 109/333 (32%), Positives = 149/333 (44%), Gaps = 46/333 (13%)
Query: 35 SYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93
SYT EC DG+ P+ C D E E + C + +S + G
Sbjct: 2313 SYTCECNDGFTASPNQDECLDNREGYCFTEVLQN--MCQIGSSNRNPVTKSECCCDGGRG 2370
Query: 94 EGPPPPVPPAQ----HPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC 149
GP + P Q CP G + D+DEC + +HD + +C N GSY C
Sbjct: 2371 WGPHCEICPFQGTVAFKKLCPHG--RGFMTNGADIDEC-KVIHDVCRNGECVNDRGSYHC 2427
Query: 150 TCPDGYRK--IGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205
C GY G CVD++EC + C C N GS++C C G+ L + RSC D++
Sbjct: 2428 ICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD 2487
Query: 206 EC-DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR--CVNEP 262
EC C+ C N+ G F C+C G+ H SC D +EC+ LC + C N P
Sbjct: 2488 ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT--SCIDNNECTSDINLCGSKGICQNTP 2545
Query: 263 GRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYR------------- 308
G F+C C +G+ L T C+D+DECE G H+C C N GGYR
Sbjct: 2546 GSFTCECQRGFSLDQTGSSCEDVDECE-GNHRCQHG--CQNIIGGYRCSCPQGYLQHYQW 2602
Query: 309 --CVDTNRCVEPYI--------QVSENRCLCPA 331
CVD N C+ +I + +C+CPA
Sbjct: 2603 NQCVDENECLSAHICGGASCHNTLGSYKCMCPA 2635
Score = 158 bits (400), Expect = 8e-39
Identities = 106/345 (30%), Positives = 148/345 (42%), Gaps = 45/345 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------PRSAAVI 88
C DG+ D + C DVNEC P C C N G ++C I
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGT-CENTKGSFICHCDMGYSGKKGKTGCTDI 1323
Query: 89 NDLH------GEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHN 142
N+ G+ C PG+ D C D+DEC+ H C DC N
Sbjct: 1324 NECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGI-KCTDLDECSNGTHMCSQHADCKN 1382
Query: 143 LPGSYQCTCPDGYRKIGPECVDIDEC--RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNR 199
GSY+C C +GY G C D+DEC C + +C+N PG +RC+C+ GF + +
Sbjct: 1383 TMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGK 1442
Query: 200 SCVDVNECDMGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRC 258
+C D++EC + C C N G F C C GYEL R G +C+D++EC + C
Sbjct: 1443 ACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNC 1502
Query: 259 VNEPGRFSCHCPQGYQLLATRL-CQDI--DEC--------ESGAHQC--------SEAQT 299
VN PG + C CP ++L TR+ C D C ++G C S+A
Sbjct: 1503 VNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASC 1562
Query: 300 CVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIV 344
C + G C P + SE + LCP R P +++
Sbjct: 1563 CCSL-GKAWGTPCEMC--PAVNTSEYKILCPGGEGF-RPNPITVI 1603
Score = 155 bits (391), Expect = 9e-38
Identities = 99/298 (33%), Positives = 137/298 (45%), Gaps = 44/298 (14%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
EC G+ ++ C D++EC P C+ +CIN G Y C
Sbjct: 1792 ECPVGFFYNDKLLVCEDIDECQNGP-VCQRNAECINTAGSYRC----------------- 1833
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
C PGY C D +EC + + C Q C + GS+ C C G++
Sbjct: 1834 ----------DCKPGYRFTSTGQCNDRNECQEIPNICSHGQ-CIDTVGSFYCLCHTGFKT 1882
Query: 158 IGPE--CVDIDECRYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP-- 212
+ C+DI+EC C + C N GSF C+C GF L NN C+DV+EC G
Sbjct: 1883 NDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNN-DCIDVDECASGNGNL 1941
Query: 213 CEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGRFSCHCP 270
C +C N+ G+F C+C++GYE+ DG +C DI+EC C C N G + C CP
Sbjct: 1942 CRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICP 2001
Query: 271 QGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY-IQVSENRC 327
GY L C+DIDEC C+ TC N G ++C+ C E + + S RC
Sbjct: 2002 PGYS-LQNEKCEDIDECVEEPEICA-LGTCSNTEGSFKCL----CPEGFSLSSSGRRC 2053
Score = 155 bits (391), Expect = 9e-38
Identities = 109/350 (31%), Positives = 145/350 (41%), Gaps = 108/350 (30%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C +GYE PD + C D+NECL P C C N G Y C+
Sbjct: 1957 QCNEGYEVAPDGRTCVDINECLLEPRKC-APGTCQNLDGSYRCI---------------- 1999
Query: 98 PPVPPAQHPNPCPPGY-----EPDDQDSCVDVDE-----------------CAQALHDCR 135
CPPGY + +D D CV+ E C +
Sbjct: 2000 -----------CPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSS 2048
Query: 136 PSQDCHNLPGSY---------------------QCTC-----------------PD-GYR 156
+ C +L SY +C C PD +R
Sbjct: 2049 SGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFR 2108
Query: 157 KIGP-----------ECVDIDECRYR-YCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVD 203
+I P VD+DEC+ C+H +C+N GS+RC+C G+ L N CVD
Sbjct: 2109 QICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNE--CVD 2166
Query: 204 VNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEP 262
+EC +G PC C N G F C C +G+E +C DI+EC+ + LC +RCVN
Sbjct: 2167 TDECSVGNPCGNGTCKNVIGGFECTCEEGFE-PGPMMTCEDINECAQNPLLCAFRCVNTY 2225
Query: 263 GRFSCHCPQGYQLLA-TRLCQDIDECESGAHQCSEAQ-TCVNFHGGYRCV 310
G + C CP GY L R+C+D DECE G H C+E Q C N G Y C+
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI 2275
Score = 154 bits (389), Expect = 2e-37
Identities = 100/307 (32%), Positives = 143/307 (46%), Gaps = 61/307 (19%)
Query: 54 DVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGY 113
D++EC IP C+ + CIN G + C CP G+
Sbjct: 1766 DIDECREIPGVCENGV-CINMVGSFRC---------------------------ECPVGF 1797
Query: 114 EPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGP-ECVDIDECRY- 170
+D+ C D+DEC C+ + +C N GSY+C C GYR +C D +EC+
Sbjct: 1798 FYNDKLLVCEDIDECQNG-PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEI 1856
Query: 171 -RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRC 228
C H +C++ GSF C C GF+ + C+D+NEC+ A C N+ G+F CRC
Sbjct: 1857 PNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRC 1916
Query: 229 HQGYELHRDGFSCSDIDEC-SYSSYLCQY-RCVNEPGRFSCHCPQGYQLLAT-RLCQDID 285
+ G+ L + C D+DEC S + LC+ +C+N G F C C +GY++ R C DI+
Sbjct: 1917 NHGFILSHNN-DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDIN 1975
Query: 286 ECESGAHQCSEAQTCVNFHGGYRCV-------------DTNRCV-EPYI--------QVS 323
EC +C+ TC N G YRC+ D + CV EP I
Sbjct: 1976 ECLLEPRKCAPG-TCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEG 2034
Query: 324 ENRCLCP 330
+CLCP
Sbjct: 2035 SFKCLCP 2041
Score = 152 bits (384), Expect = 6e-37
Identities = 103/329 (31%), Positives = 145/329 (44%), Gaps = 58/329 (17%)
Query: 36 YTECTDGYEWDPDSQHCRDVNE--CLT----------IPEACKGEMKCINHYGGY----- 78
+ +C G+ PD C DV C T +P++ +M+C G
Sbjct: 312 FCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSIT-KMQCCCDAGRCWSPGV 370
Query: 79 -----LCLPRSAAVINDL---------HGEGPPPPVPPAQHPNPCPPGYEPDDQDSC--- 121
+C R+ N L E PPPP+ P P PPG+ P Q
Sbjct: 371 TVAPEMCPIRATEDFNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIPVPRP 430
Query: 122 ----------------VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-KIGPECVD 164
V+V + Q + + C PGS +C C G++ + EC+D
Sbjct: 431 PVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECID 490
Query: 165 IDECRYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSY 221
+DEC C C+N GS+ CQC G+Q C D++EC G C RC N+
Sbjct: 491 VDECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTD 550
Query: 222 GTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RL 280
G+F C C+ G+ + RDG +C D+DECS + C+NE G F C C G+QL + R
Sbjct: 551 GSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRY 610
Query: 281 CQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C+DI+ECE+ C + CVN G YRC
Sbjct: 611 CKDINECETPG-ICMNGR-CVNTDGSYRC 637
Score = 144 bits (363), Expect = 2e-34
Identities = 85/257 (33%), Positives = 123/257 (47%), Gaps = 44/257 (17%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C GY + Q C D NEC IP C +CI+ G + CL
Sbjct: 1834 DCKPGYRFTSTGQ-CNDRNECQEIPNIC-SHGQCIDTVGSFYCL---------------- 1875
Query: 98 PPVPPAQHPNPCPPGYEP-DDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY- 155
C G++ DDQ C+D++EC + D + C N GS+ C C G+
Sbjct: 1876 -----------CHTGFKTNDDQTMCLDINECER---DACGNGTCRNTIGSFNCRCNHGFI 1921
Query: 156 RKIGPECVDIDEC---RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC--DM 209
+C+D+DEC C++ +C+N GSF+CQC G+++ P+ R+CVD+NEC +
Sbjct: 1922 LSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEP 1981
Query: 210 GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCH 268
C N G++ C C GY L + C DIDEC +C C N G F C
Sbjct: 1982 RKCAPGTCQNLDGSYRCICPPGYSLQNE--KCEDIDECVEEPEICALGTCSNTEGSFKCL 2039
Query: 269 CPQGYQLLAT-RLCQDI 284
CP+G+ L ++ R CQD+
Sbjct: 2040 CPEGFSLSSSGRRCQDL 2056
Score = 140 bits (354), Expect = 2e-33
Identities = 93/297 (31%), Positives = 132/297 (44%), Gaps = 34/297 (11%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------PRSAAVI 88
C G+ PD + C D++EC P C G +C N G Y CL ++ +
Sbjct: 1223 CQPGFALMPDQRSCTDIDECEDNPNICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDV 1281
Query: 89 ND--------LHGEGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQD 139
N+ L G H C GY + C D++EC H+C
Sbjct: 1282 NECDLNPNICLSGTCENTKGSFICH---CDMGYSGKKGKTGCTDINECEIGAHNCGKHAV 1338
Query: 140 CHNLPGSYQCTCPDGYRKIGPECVDIDEC---RYRYCQHR-CVNLPGSFRCQCEPGFQLG 195
C N GS++C+C G+ G +C D+DEC + QH C N GS+RC C+ G+
Sbjct: 1339 CTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT-- 1396
Query: 196 PNNRSCVDVNEC--DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYL 253
+ +C D++EC ++ +C N+ G + C C G+ DG +C DIDECS +
Sbjct: 1397 GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNIC 1456
Query: 254 CQYRCVNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C N PG F C C GY+L + C D++EC S CVN G Y C
Sbjct: 1457 VFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCIS--GNCVNTPGSYIC 1511
Score = 134 bits (336), Expect = 2e-31
Identities = 82/232 (35%), Positives = 117/232 (50%), Gaps = 27/232 (11%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI--GPECVDID 166
C G++ D + C+DVDEC + + C + C N GSY C C GY+ EC DID
Sbjct: 476 CNKGFQLDLRGECIDVDECEK--NPCAGGE-CINNQGSYTCQCRAGYQSTLTRTECRDID 532
Query: 167 ECRY--RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC-EQRCFNSYG 222
EC R C + RC+N GSF C C GF + + ++C D++EC + C C N G
Sbjct: 533 ECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDG 592
Query: 223 TFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQL-LATRLC 281
+F C C G++L DG C DI+EC RCVN G + C C G + L R+C
Sbjct: 593 SFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVC 652
Query: 282 QDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP-YIQVSENRCLCPAS 332
D H S TC +GGY+ +C++P + V+++ C C ++
Sbjct: 653 VD-------THMRS---TC---YGGYK---RGQCIKPLFGAVTKSECCCAST 688
Score = 130 bits (327), Expect = 2e-30
Identities = 94/297 (31%), Positives = 133/297 (44%), Gaps = 38/297 (12%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY +Q C D++EC P CK + C+N G + C S + D G
Sbjct: 896 CGKGYSRIKGTQ-CEDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTL-DATGR---- 948
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVD----VDECAQALHDCRPSQDCHNLP----GSYQCT 150
+ C YE ++ + +D C ++ +++C P Y+
Sbjct: 949 -ICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEEL 1007
Query: 151 CPDGYRKIGPECV-------DIDECRY--RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRS 200
CP G E DI+EC+ C H +C N GSF+C+C+ GF L R+
Sbjct: 1008 CPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERN 1067
Query: 201 CVDVNECDMGAPC--EQRCFNSYGTFLCRCHQGYELHRDGF----SCSDIDECSYSSYLC 254
C D++EC + +C N+ G F C+C +GYE GF +C DIDEC LC
Sbjct: 1068 CTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYE---SGFMMMKNCMDIDECQRDPLLC 1124
Query: 255 QYR-CVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
+ C N G + C CP G+QL C DI+ECE AH C + CVN G Y+C
Sbjct: 1125 RGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGR-CVNLIGKYQC 1180
Score = 126 bits (317), Expect = 3e-29
Identities = 103/361 (28%), Positives = 138/361 (38%), Gaps = 100/361 (27%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C+ W D C D++EC C C N G Y CL
Sbjct: 1347 KCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCL---------------- 1390
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY-- 155
C GY D +C D+DEC++ L+ C Q C N PG Y+C C G+
Sbjct: 1391 -----------CKEGY-TGDGFTCTDLDECSENLNLCGNGQ-CLNAPGGYRCECDMGFVP 1437
Query: 156 RKIGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC 213
G C DIDEC C C NLPG FRC+CE G++L + +C DVNEC C
Sbjct: 1438 SADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTC 1497
Query: 214 -EQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYL--------CQYRCVNEPG- 263
C N+ G+++C C +EL+ C +D S + YL C NE G
Sbjct: 1498 ISGNCVNTPGSYICDCPPDFELNPTRVGC--VDTRSGNCYLDIRPRGDNGDTACSNEIGV 1555
Query: 264 ---RFSCHCPQG-----------------YQLLA-----------TRLCQDIDECESGAH 292
+ SC C G Y++L T + +DIDEC+
Sbjct: 1556 GVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPG 1615
Query: 293 QCSEAQTCVNFHGGYR---------------CVDTNRCVEP--------YIQVSENRCLC 329
C + C+N G ++ C D N C P Y V C+C
Sbjct: 1616 LC-QGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCIC 1674
Query: 330 P 330
P
Sbjct: 1675 P 1675
Score = 125 bits (313), Expect = 1e-28
Identities = 100/352 (28%), Positives = 139/352 (39%), Gaps = 82/352 (23%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEAC-KGEMKCINHYGGYLCLPRSAAVINDLHGEGP 96
+C GY D + C+D +EC C + +M+C N G Y+C+
Sbjct: 2231 KCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI--------------- 2275
Query: 97 PPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
C PGY+ D + CVD +EC C + C N GSY C C DG+
Sbjct: 2276 ------------CGPGYQRRPDGEGCVDENECQTKPGICENGR-CLNTRGSYTCECNDGF 2322
Query: 156 RKI--GPECVDIDE--CRYRYCQHRCV------NLPGSFRCQCEPGFQLGPNNRSC---- 201
EC+D E C Q+ C N C C+ G GP+ C
Sbjct: 2323 TASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQG 2382
Query: 202 ------------------VDVNECD-MGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSC 241
D++EC + C C N G++ C C GY G SC
Sbjct: 2383 TVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSC 2442
Query: 242 SDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTC 300
D++EC+ + C + C N G + C CP+GY L R C+D+DEC + H C C
Sbjct: 2443 VDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQ--FLC 2500
Query: 301 VNFHGGYRCVDTNRCVEPYIQ-----VSENRC-----LCPASNPLCREQPSS 342
VN GG+ C +C + Q + N C LC S +C+ P S
Sbjct: 2501 VNTIGGFTC----KCPPGFTQHHTSCIDNNECTSDINLC-GSKGICQNTPGS 2547
Score = 118 bits (295), Expect = 1e-26
Identities = 101/342 (29%), Positives = 135/342 (39%), Gaps = 82/342 (23%)
Query: 36 YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEG 95
Y C G++ + D C D+NEC +AC G C N G + C
Sbjct: 1873 YCLCHTGFKTNDDQTMCLDINECER--DAC-GNGTCRNTIGSFNC--------------- 1914
Query: 96 PPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
C G+ + C+DVDECA + + C N GS+QC C +GY
Sbjct: 1915 ------------RCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGY 1962
Query: 156 RKI--GPECVDIDEC--RYRYC-QHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC--D 208
G CVDI+EC R C C NL GS+RC C PG+ L N C D++EC +
Sbjct: 1963 EVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSL--QNEKCEDIDECVEE 2020
Query: 209 MGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDI-----------DECS------YSS 251
C N+ G+F C C +G+ L G C D+ +CS +S
Sbjct: 2021 PEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSK 2080
Query: 252 YLCQYR------------CVNEPGR-FSCHCPQGYQLLA--TRLCQDIDECESGAHQCSE 296
C C EP F CP G ++ D+DEC+ C
Sbjct: 2081 QECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKE-PDVCKH 2139
Query: 297 AQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL----CPASNP 334
Q C+N G YRC C YI ++ N C+ C NP
Sbjct: 2140 GQ-CINTDGSYRC----ECPFGYI-LAGNECVDTDECSVGNP 2175
Score = 117 bits (292), Expect = 3e-26
Identities = 100/360 (27%), Positives = 155/360 (43%), Gaps = 72/360 (20%)
Query: 41 DGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVINDLHG 93
+G+ +P + D++EC +P C+G KCIN +G + C L V +D++
Sbjct: 1593 EGFRPNPITVILEDIDECQELPGLCQGG-KCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651
Query: 94 EGPPPPVPPAQHPNP-------CPPGY-EPDDQDSCVDVDECAQALHDCRPSQDC----- 140
P P N CPP Y + + ++C+D+ + +Q C
Sbjct: 1652 CETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELL 1711
Query: 141 -----------HNLPGSY-----QCTCPD--------GYRKIGPEC-------VDIDECR 169
+N+ ++ QC P G ++ G VDIDECR
Sbjct: 1712 FNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECR 1771
Query: 170 Y--RYCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQ--RCFNSYGTF 224
C++ C+N+ GSFRC+C GF C D++EC G C++ C N+ G++
Sbjct: 1772 EIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSY 1831
Query: 225 LCRCHQGYELHRDGFSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQLLATR-LCQ 282
C C GY G C+D +EC +C + +C++ G F C C G++ + +C
Sbjct: 1832 RCDCKPGYRFTSTG-QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCL 1890
Query: 283 DIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL----CPASN-PLCR 337
DI+ECE A C TC N G + C RC +I N C+ C + N LCR
Sbjct: 1891 DINECERDA--CGNG-TCRNTIGSFNC----RCNHGFILSHNNDCIDVDECASGNGNLCR 1943
Score = 116 bits (290), Expect = 5e-26
Identities = 102/372 (27%), Positives = 141/372 (37%), Gaps = 91/372 (24%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLH------ 92
C G+ + PD + C D++EC + P C + C N G ++C S + ++
Sbjct: 792 CPKGFIYKPDLKTCEDIDECESSP--CINGV-CKNSPGSFICECSSESTLDPTKTICIET 848
Query: 93 -------------------------------GEGPPPPVPPAQHPNPCPPGYEPDDQDSC 121
G P Q C GY C
Sbjct: 849 IKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQC 908
Query: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR--KIGPECVDI--DECRYRYCQHRC 177
D+DEC C+ C N GS++C CP G G C+DI + C RY C
Sbjct: 909 EDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEEC 967
Query: 178 -VNLPGSFRC--------------QCE-----------------PGF---QLGPNNRSCV 202
+ + G R +CE PGF ++
Sbjct: 968 TLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFK 1027
Query: 203 DVNECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCV 259
D+NEC M +C N+ G+F CRC G+ L + +C+DIDEC S LC + +CV
Sbjct: 1028 DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCV 1087
Query: 260 NEPGRFSCHCPQGYQ--LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVE 317
N PG F C C +GY+ + + C DIDEC+ C C N G YRC C
Sbjct: 1088 NTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLC-RGGVCHNTEGSYRC----EC-P 1141
Query: 318 PYIQVSENRCLC 329
P Q+S N C
Sbjct: 1142 PGHQLSPNISAC 1153
Score = 115 bits (288), Expect = 8e-26
Identities = 96/354 (27%), Positives = 144/354 (40%), Gaps = 78/354 (22%)
Query: 35 SYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93
SYT +C GY+ CRD++ECL C +CIN G + C+
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG-RCINTDGSFHCV------------ 556
Query: 94 EGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
C G+ D +C D+DEC ++ + + C N GS++C C
Sbjct: 557 ---------------CNAGFHVTRDGKNCEDMDEC--SIRNMCLNGMCINEDGSFKCICK 599
Query: 153 DGYR--KIGPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVN--- 205
G++ G C DI+EC C + RCVN GS+RC+C PG +G + R CVD +
Sbjct: 600 PGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRS 659
Query: 206 -----------------------------ECDMGAPCEQRCFNSYGTFLCRCHQGYELHR 236
E G PC+ + + C G +
Sbjct: 660 TCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTS 719
Query: 237 DGFSCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQC 294
G SDI+EC+ +C C N G + C C GY++ +T + C DI+EC + C
Sbjct: 720 AG---SDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLC 776
Query: 295 SEAQTCVNFHGGYRCVDTNRCV-EPYIQVSENRCLC---PASNPLCREQPSSIV 344
Q C N G + C + +P ++ E+ C P N +C+ P S +
Sbjct: 777 DNGQ-CRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFI 829
Score = 115 bits (288), Expect = 8e-26
Identities = 94/342 (27%), Positives = 134/342 (39%), Gaps = 75/342 (21%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVINDL 91
C G++ D ++C+D+NEC T P C +C+N G Y C + V D
Sbjct: 598 CKPGFQLASDGRYCKDINECET-PGICMNG-RCVNTDGSYRCECFPGLAVGLDGRVCVDT 655
Query: 92 H-------GEGPPPPVPP-------------------AQHPNPCPPGYEPDDQDSCV--- 122
H G + P + PCP + Q C
Sbjct: 656 HMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGP 715
Query: 123 -------DVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR--KIGPECVDIDECRYR-- 171
D++ECA C P+ C NL G+Y+C C GY G CVDI+EC
Sbjct: 716 GMTSAGSDINECALDPDIC-PNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSL 774
Query: 172 YCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ 230
C + +C N PGSF C C GF P+ ++C D++EC+ C NS G+F+C C
Sbjct: 775 LCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSS 834
Query: 231 GYELHRDGFSCSD----------ID---ECSYSSYLCQYRCVNEPG----------RFSC 267
L C + ID E + + + +C + G +
Sbjct: 835 ESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDP 894
Query: 268 HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C +GY + C+DIDECE C CVN G ++C
Sbjct: 895 ICGKGYSRIKGTQCEDIDECEVFPGVCKNG-LCVNTRGSFKC 935
Score = 112 bits (280), Expect = 7e-25
Identities = 94/309 (30%), Positives = 131/309 (42%), Gaps = 59/309 (19%)
Query: 54 DVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVINDLHGEGPPPPVPPAQH- 105
D++EC P+ CK +CIN G Y C L + V D G P ++
Sbjct: 2127 DMDECKE-PDVCK-HGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNV 2184
Query: 106 ----PNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY--RKIG 159
C G+EP +C D++ECAQ C + C N GSY+C CP GY R+
Sbjct: 2185 IGGFECTCEEGFEPGPMMTCEDINECAQNPLLC--AFRCVNTYGSYECKCPVGYVLREDR 2242
Query: 160 PECVDIDECRY--RYC---QHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD-MGAPC 213
C D DEC C Q C NL G++ C C PG+Q P+ CVD NEC C
Sbjct: 2243 RMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGIC 2302
Query: 214 EQ-RCFNSYGTFLCRCHQGYEL---------HRDGFSCSDI--DECSYSSY----LCQYR 257
E RC N+ G++ C C+ G+ +R+G+ +++ + C S + +
Sbjct: 2303 ENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSE 2362
Query: 258 CVNEPGR----------------FSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCV 301
C + GR F CP G + DIDEC+ C + CV
Sbjct: 2363 CCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG--ADIDECKVIHDVCRNGE-CV 2419
Query: 302 NFHGGYRCV 310
N G Y C+
Sbjct: 2420 NDRGSYHCI 2428
Score = 93.6 bits (231), Expect = 3e-19
Identities = 86/317 (27%), Positives = 119/317 (37%), Gaps = 76/317 (23%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
+C G++ + SQ C D++EC TIP C+G +C N Y C
Sbjct: 272 KCPAGHKLNEVSQKCEDIDECSTIPGICEGG-ECTNTVSSYFC----------------- 313
Query: 98 PPVPPAQHPNPCPPG-YEPDDQDSCVDV--DECAQALHDCRPSQDCHNLPGSYQCTCPDG 154
CPPG Y D C+DV C AL + R S QC C G
Sbjct: 314 ----------KCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAG 363
Query: 155 Y-----RKIGPECVDI--DECRYRYCQHRCVNLPGSFR------------CQCEPGFQLG 195
+ PE I E + C V +PG PGF G
Sbjct: 364 RCWSPGVTVAPEMCPIRATEDFNKLCSVPMV-IPGRPEYPPPPLGPIPPVLPVPPGFPPG 422
Query: 196 PN-------------NRSCVDVNECDMGAPCE--------QRCFNSYGTFLCRCHQGYEL 234
P +R V ++ C+ RC + G+ C C++G++L
Sbjct: 423 PQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQL 482
Query: 235 HRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQ 293
G C D+DEC + C+N G ++C C GYQ TR C+DIDEC
Sbjct: 483 DLRG-ECIDVDECE-KNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRI 540
Query: 294 CSEAQTCVNFHGGYRCV 310
C+ + C+N G + CV
Sbjct: 541 CNNGR-CINTDGSFHCV 556
Score = 93.6 bits (231), Expect = 3e-19
Identities = 97/363 (26%), Positives = 136/363 (37%), Gaps = 93/363 (25%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PR-------------- 83
C GYE D ++C D+NEC+ C +C N G ++C P+
Sbjct: 750 CNSGYEVDSTGKNCVDINECVLNSLLCDNG-QCRNTPGSFVCTCPKGFIYKPDLKTCEDI 808
Query: 84 ----SAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDE--CAQALHDCR-- 135
S+ IN + P + + P + C++ + C Q + D R
Sbjct: 809 DECESSPCINGVCKNSPGSFICECSSESTLDP-----TKTICIETIKGTCWQTVIDGRCE 863
Query: 136 --------PSQDCHNLPGSY--QCT-------CPDGYRKI-GPECVDIDECRY--RYCQH 175
SQ C +L ++ CT C GY +I G +C DIDEC C++
Sbjct: 864 ININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKN 923
Query: 176 R-CVNLPGSFRCQCEPGFQLGPNNRSCVDVNE--------------------------CD 208
CVN GSF+CQC G L R C+D+ C
Sbjct: 924 GLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCS 983
Query: 209 MGA-----PCEQRCFNSYGTFLCRCHQG-----YELHRDGFSCSDIDECSYSSYLCQY-R 257
+GA CE+ + + C +G E+ DI+EC LC + +
Sbjct: 984 VGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGK 1043
Query: 258 CVNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCV 316
C N G F C C G+ L R C DIDEC C Q CVN G + C +C
Sbjct: 1044 CRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ-CVNTPGDFEC----KCD 1098
Query: 317 EPY 319
E Y
Sbjct: 1099 EGY 1101
Score = 90.1 bits (222), Expect = 4e-18
Identities = 83/322 (25%), Positives = 123/322 (38%), Gaps = 66/322 (20%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC------LPRSAAVINDLH 92
C +GY D + C D++EC C G +C+N GGY C +P + +
Sbjct: 1391 CKEGYTGDGFT--CTDLDECSENLNLC-GNGQCLNAPGGYRCECDMGFVPSADGKACEDI 1447
Query: 93 GEGPPPPVP--------PAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNL 143
E P + P C GYE D +C DV+EC S +C N
Sbjct: 1448 DECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCI--SGNCVNT 1505
Query: 144 PGSYQCTCPDGYRKIGPECVDIDECRYRYCQ-------------------------HRCV 178
PGSY C CP + ++ P V + R C C
Sbjct: 1506 PGSYICDCPPDF-ELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCC 1564
Query: 179 NLPGSFRCQCE-----------------PGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFN 219
+L ++ CE GF+ P D++EC ++ C+ +C N
Sbjct: 1565 SLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCIN 1624
Query: 220 SYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGY-QLLAT 278
++G+F CRC GY L+ D C D++EC C N G ++C CP Y Q+
Sbjct: 1625 TFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGG 1684
Query: 279 RLCQDIDECESGAHQCSEAQTC 300
C D+ + ++ QTC
Sbjct: 1685 NNCMDMRRSLCYRNYYADNQTC 1706
Score = 82.0 bits (201), Expect = 1e-15
Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 18/174 (10%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTI--PEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGP 96
CT G+ P + C T+ + C+G++ G +C ++ G
Sbjct: 168 CTYGFT-GPQCERDYRTGPCFTVISNQMCQGQLS------GIVCT-KTLCCATVGRAWGH 219
Query: 97 PPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155
P + PAQ P+PC G+ P+ + +C DVDEC QA+ +C N GS++C CP G+
Sbjct: 220 PCEMCPAQ-PHPCRRGFIPNIRTGACQDVDEC-QAIPGLCQGGNCINTVGSFECKCPAGH 277
Query: 156 R--KIGPECVDIDECRY--RYCQ-HRCVNLPGSFRCQCEPGFQLGPNNRSCVDV 204
+ ++ +C DIDEC C+ C N S+ C+C PGF P+ C+DV
Sbjct: 278 KLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Score = 80.9 bits (198), Expect = 2e-15
Identities = 62/187 (33%), Positives = 75/187 (40%), Gaps = 41/187 (21%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P S+T EC G+ D C DV+EC G C N GGY C
Sbjct: 2545 PGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHG---CQNIIGGYRC----------- 2590
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQ-DSCVDVDECAQALHDCRPSQDCHNLPGSYQCT 150
CP GY Q + CVD +EC A H C CHN GSY+C
Sbjct: 2591 ----------------SCPQGYLQHYQWNQCVDENECLSA-HIC-GGASCHNTLGSYKCM 2632
Query: 151 CPDG--YRKIGPECVDIDEC--RYRYCQHRCVNLPGSFRCQCEPG-FQLGPNNRSCVDVN 205
CP G Y + C DI+EC C + C N G + C C PG F++G + CV
Sbjct: 2633 CPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGH--CVSGM 2690
Query: 206 ECDMGAP 212
G P
Sbjct: 2691 GMGRGNP 2697
Score = 67.0 bits (162), Expect = 3e-11
Identities = 49/168 (29%), Positives = 66/168 (39%), Gaps = 28/168 (16%)
Query: 188 CEPGFQLGPNNRSCVDVNECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDID 245
C GF +C DV+EC G C N+ G+F C+C G++L+ C DID
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 246 ECSYSSYLCQ-YRCVNEPGRFSCHCPQGYQLL--ATRLCQDI-----------DECESGA 291
ECS +C+ C N + C CP G+ TR C D+ C +
Sbjct: 291 ECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTR-CIDVRPGYCYTALTNGRCSNQL 349
Query: 292 HQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPAS---NPLC 336
Q C C D RC P + V+ C A+ N LC
Sbjct: 350 PQSITKMQC--------CCDAGRCWSPGVTVAPEMCPIRATEDFNKLC 389
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 172 bits (437), Expect = 4e-43
Identities = 112/330 (33%), Positives = 146/330 (44%), Gaps = 43/330 (13%)
Query: 38 ECTDGYEWD-PDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVIN 89
EC GYE ++C DV+EC P C+G C N G Y C L
Sbjct: 1054 ECFPGYESGFMLMKNCMDVDECARDPLLCRGGT-CTNTDGSYKCQCPPGHELTAKGTACE 1112
Query: 90 DLHGEGPPPPV-PPAQHPN-------PCPPGYEPD-DQDSCVDVDECAQALHDCRPSQDC 140
D+ + P Q N C G++ D+ CVD++EC C C
Sbjct: 1113 DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC--DVHC 1170
Query: 141 HNLPGSYQCTCPDGYRKI--GPECVDIDECRY--RYC-QHRCVNLPGSFRCQCEPGFQLG 195
N GSY+C+C GY + G C D+DEC R C Q C N+PG RC C GF
Sbjct: 1171 INTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT 1230
Query: 196 PNNRSCVDVNECDMGAP--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYL 253
P+ R+CVDV+ECD+ C N+ G+F+C C GY + + CSD+DEC +
Sbjct: 1231 PDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
Query: 254 CQYR--CVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV- 310
C C+N PG FSC C G+ C D+DEC S H+CS C+N G YRC
Sbjct: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGFE-CHDLDECVSQEHRCSPRGDCLNVPGSYRCTC 1349
Query: 311 ------------DTNRCVEPYIQVSENRCL 328
D + C E +CL
Sbjct: 1350 RQGFAGDGFFCEDRDECAENVDLCDNGQCL 1379
Score = 165 bits (417), Expect = 9e-41
Identities = 97/297 (32%), Positives = 129/297 (43%), Gaps = 44/297 (14%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY D + C D++EC +P+ C C N G +LC
Sbjct: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC------------------ 2429
Query: 99 PVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
CP GY +D +C D+DEC H+C+ C N G++ C CP G+ +
Sbjct: 2430 ---------SCPRGYLLEEDGRTCKDLDECTSRQHNCQFL--CVNTVGAFTCRCPPGFTQ 2478
Query: 158 IGPECVDIDECRYRY----CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC 213
C D DEC + C N PGSFRC+C GF L + C DVNECD C
Sbjct: 2479 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC 2538
Query: 214 EQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-QYRCVNEPGRFSCHCPQG 272
+ C N G + C C QG+ H C D +EC+ S C C N G F C CP G
Sbjct: 2539 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG 2598
Query: 273 YQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL 328
+ A CQ++DEC CS +C N GG+ C C + Y + + C+
Sbjct: 2599 FDFDQALGGCQEVDECAGRRGPCS--YSCANTPGGFLC----GCPQGYFRAGQGHCV 2649
Score = 162 bits (409), Expect = 7e-40
Identities = 94/257 (36%), Positives = 127/257 (49%), Gaps = 22/257 (8%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-------LPRSAAVINDL 91
C DG+ PD + C DV+EC P C C N G ++C + + A +D+
Sbjct: 1223 CYDGFMATPDMRTCVDVDECDLNPHICL-HGDCENTKGSFVCHCQLGYMVRKGATGCSDV 1281
Query: 92 H-----GEGPPPPVP----PAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHN 142
G P C PG+ D + C D+DEC H C P DC N
Sbjct: 1282 DECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE-CHDLDECVSQEHRCSPRGDCLN 1340
Query: 143 LPGSYQCTCPDGYRKIGPECVDIDEC--RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNR 199
+PGSY+CTC G+ G C D DEC C + +C+N PG +RC+CE GF ++R
Sbjct: 1341 VPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHR 1400
Query: 200 SCVDVNECDMGAPCE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRC 258
+C DV+EC G C C N G F C C+ GYEL R G +C+DI+EC+ C
Sbjct: 1401 ACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVC 1460
Query: 259 VNEPGRFSCHCPQGYQL 275
+N PG + C CPQ ++L
Sbjct: 1461 INTPGSYLCSCPQDFEL 1477
Score = 160 bits (406), Expect = 2e-39
Identities = 100/283 (35%), Positives = 129/283 (45%), Gaps = 47/283 (16%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G++ PD Q C D+NEC C ++ CIN G Y C
Sbjct: 1140 CHAGFQSTPDRQGCVDINECRVQNGGC--DVHCINTEGSYRC------------------ 1179
Query: 99 PVPPAQHPNPCPPGYE--PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
C GY PD + +C DVDEC + C C N+PG ++C C DG+
Sbjct: 1180 ---------SCGQGYSLMPDGR-ACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFM 1228
Query: 157 KIGP--ECVDIDEC--RYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
CVD+DEC C H C N GSF C C+ G+ + C DV+EC++G
Sbjct: 1229 ATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGG 1288
Query: 212 -PCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR--CVNEPGRFS 266
C+ C N G+F CRC G+ DGF C D+DEC + C R C+N PG +
Sbjct: 1289 HNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYR 1346
Query: 267 CHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C C QG+ C+D DEC C Q C+N GGYRC
Sbjct: 1347 CTCRQGFAGDGF-FCEDRDECAENVDLCDNGQ-CLNAPGGYRC 1387
Score = 157 bits (398), Expect = 1e-38
Identities = 89/268 (33%), Positives = 120/268 (44%), Gaps = 40/268 (14%)
Query: 53 RDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPG 112
+DVNEC P C C N G + C C G
Sbjct: 985 KDVNECKVFPGLCT-HGTCRNTVGSFHCA---------------------------CAGG 1016
Query: 113 YEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK---IGPECVDIDEC 168
+ D Q+ +C D+DEC + C C N PGS++C C GY + C+D+DEC
Sbjct: 1017 FALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECFPGYESGFMLMKNCMDVDEC 1075
Query: 169 RYRYCQHR---CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDM--GAPCEQRCFNSYGT 223
R C N GS++CQC PG +L +C D++EC + G +C N G
Sbjct: 1076 ARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
Query: 224 FLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQ 282
F C CH G++ D C DI+EC + C C+N G + C C QGY L+ R C
Sbjct: 1136 FQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA 1195
Query: 283 DIDECESGAHQCSEAQTCVNFHGGYRCV 310
D+DECE C + C N GG+RC+
Sbjct: 1196 DVDECEENPRVCDQGH-CTNMPGGHRCL 1222
Score = 152 bits (383), Expect = 8e-37
Identities = 105/326 (32%), Positives = 141/326 (43%), Gaps = 62/326 (19%)
Query: 38 ECTDGYEWDPDSQHCRDV--------------------NECLTIPEACKG---------- 67
+C +G++ P C D+ +E +T E C G
Sbjct: 2278 DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE 2337
Query: 68 ---------EMKCINHYGGYLCLPRSAAVINDL-----HGEGPPPPVPPAQHPNPCPPGY 113
K H GY R L HGE H C GY
Sbjct: 2338 LCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCH---CQAGY 2394
Query: 114 EPD-DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY--RKIGPECVDIDEC-- 168
PD +C+D+DEC+Q C + C N GS+ C+CP GY + G C D+DEC
Sbjct: 2395 TPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTS 2452
Query: 169 RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD-MGAPC--EQRCFNSYGTFL 225
R CQ CVN G+F C+C PGF ++++C D +EC PC C N+ G+F
Sbjct: 2453 RQHNCQFLCVNTVGAFTCRCPPGFT--QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFR 2510
Query: 226 CRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGY-QLLATRLCQDI 284
C CHQG+ L G C D++EC + CQ+ C N+ G + C CPQG+ Q C D
Sbjct: 2511 CECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDE 2569
Query: 285 DECESGAHQCSEAQTCVNFHGGYRCV 310
+EC C A +C N GG+RCV
Sbjct: 2570 NECALSPPTCGSA-SCRNTLGGFRCV 2594
Score = 151 bits (381), Expect = 1e-36
Identities = 95/296 (32%), Positives = 135/296 (45%), Gaps = 46/296 (15%)
Query: 54 DVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGY 113
D++EC IP C + CIN G + C CP G+
Sbjct: 1721 DIDECGEIPAICANGI-CINQIGSFRC---------------------------ECPAGF 1752
Query: 114 EPDD-QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR-KIGPECVDIDECRY- 170
+ +C DVDEC C+ + DC N+PGSY+C C GY+ G CV +ECR
Sbjct: 1753 NYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREI 1812
Query: 171 -RYCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRC 228
C H C++ GS+ C C GFQ + C+D++ECD C N G++ C C
Sbjct: 1813 PNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLC 1872
Query: 229 HQGYELHRDGFSCSDIDEC-SYSSYLCQY-RCVNEPGRFSCHCPQGYQLLAT-RLCQDID 285
G+ + +G C D DEC + +C++ C+N G F C C G++L A + C D +
Sbjct: 1873 FPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
Query: 286 ECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPS 341
EC S A C TC N G +RC+ P QV + C+ C E+P+
Sbjct: 1932 ECLSLAGTCLPG-TCQNLEGSFRCI-----CPPGFQVQSDHCI---DIDECSEEPN 1978
Score = 148 bits (374), Expect = 8e-36
Identities = 81/212 (38%), Positives = 114/212 (53%), Gaps = 17/212 (8%)
Query: 124 VDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK-IGPECVDIDECRYRYCQHR-CVNLP 181
+D C + C + C P SY+C C GY + + EC+D+DEC C H CVN+P
Sbjct: 409 IDICRHFTNLCLNGR-CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIP 467
Query: 182 GSFRCQCEPGFQLGPNNRSCVDVNECDM-GAPCEQ-RCFNSYGTFLCRCHQGYELHRDGF 239
G++ C+C PGFQ P ++CVDV+EC + G C RC N+ G+F C C+ G+EL DG
Sbjct: 468 GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGK 527
Query: 240 SCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRLCQDIDECESGAHQCSEAQ 298
+C D +EC+ S+ C+NE G FSC C G+ L C DIDEC++ C
Sbjct: 528 NCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG-ICVNGH 586
Query: 299 TCVNFHGGYRC---------VDTNRCVEPYIQ 321
C N G +RC D CV+ +++
Sbjct: 587 -CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVR 617
Score = 148 bits (374), Expect = 8e-36
Identities = 92/280 (32%), Positives = 129/280 (46%), Gaps = 38/280 (13%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
EC G+ ++ C DV+EC + C+ CIN G Y C
Sbjct: 1747 ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC----------------- 1789
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
C GY+ +CV +EC + + C DC + GSY C C G++
Sbjct: 1790 ----------KCTRGYKLSPGGACVGRNECREIPNVCSHG-DCMDTEGSYMCLCHRGFQA 1838
Query: 158 IGPE--CVDIDECRYRYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD--MGAP 212
+ C+DIDEC + C + C N+ GS+ C C PGF + +N CVD +EC +G
Sbjct: 1839 SADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVV-THNGDCVDFDECTTLVGQV 1897
Query: 213 CE-QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC-SYSSYLCQYRCVNEPGRFSCHCP 270
C C N+ G+F C C G+EL DG +C D +EC S + C N G F C CP
Sbjct: 1898 CRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP 1957
Query: 271 QGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
G+Q+ + C DIDEC + C TC N G ++C+
Sbjct: 1958 PGFQVQSDH-CIDIDECSEEPNLCLFG-TCTNSPGSFQCL 1995
Score = 146 bits (369), Expect = 3e-35
Identities = 108/366 (29%), Positives = 145/366 (39%), Gaps = 77/366 (21%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGE-MKCINHYGGYLCLPRSAAVINDLHGEGPP 97
C GY D CRDV+EC + C M+C N G + C+ + L G G
Sbjct: 2192 CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPG--MRPLPGSGEG 2249
Query: 98 PPVPPAQHPNP------------------CPPGYEPDDQ-DSCVDVDE---CAQALHD-C 134
H P C G++P C D+ + A+ L C
Sbjct: 2250 CTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMC 2309
Query: 135 RPSQDCHNLPGSYQCTCPDG-----------------YRKIGP-------ECVDIDECRY 170
R +C C G YRK+ P E D+DECR
Sbjct: 2310 RSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRM 2369
Query: 171 --RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD-MGAPCEQRCFNSYGTFLC 226
C H C+N GSFRC C+ G+ +C+D++EC + PC C N+ G+FLC
Sbjct: 2370 LAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLC 2429
Query: 227 RCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDE 286
C +GY L DG +C D+DEC+ + CQ+ CVN G F+C CP G+ + C D DE
Sbjct: 2430 SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGF-TQHHQACFDNDE 2488
Query: 287 CESGAHQCSEAQTCVNFHGGYR---------------CVDTNRCVEPY-------IQVSE 324
C + C C N G +R C D N C P+ Q+
Sbjct: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGG 2548
Query: 325 NRCLCP 330
RC CP
Sbjct: 2549 YRCSCP 2554
Score = 144 bits (364), Expect = 1e-34
Identities = 116/387 (29%), Positives = 155/387 (40%), Gaps = 68/387 (17%)
Query: 19 LLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGY 78
L L G+ P + + C + S HC D++EC P C C N G +
Sbjct: 1934 LSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGT-CTNSPGSF 1992
Query: 79 LCLPRSAAVINDL-----------------------------------------HGEGPP 97
CL V++D G G P
Sbjct: 1993 QCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDP 2052
Query: 98 PPVPP----AQHPNPCPPGYE--PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
+ P A CP G+ P DS DV+ECA+ C C N GS++C C
Sbjct: 2053 CELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGV-CVNTDGSFRCEC 2111
Query: 152 PDGYRK--IGPECVDIDECRYRY-C-QHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
P GY G CVD DEC + C Q C N+ G F C C GF+ G +C D++EC
Sbjct: 2112 PFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-MTCEDIDEC 2170
Query: 208 DMGAP-CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR---CVNEPG 263
+ C RC N+ G++LC C GY L DG C D+DEC+ C R C N G
Sbjct: 2171 SLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIG 2230
Query: 264 RFSCHCPQGYQLL--ATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQ 321
F+C CP G + L + C D +EC + C + CVN G +RC D + +P
Sbjct: 2231 TFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CVNTAGSFRC-DCDEGFQPSPT 2288
Query: 322 VSE------NRCLCPASNPLCREQPSS 342
++E C +CR SS
Sbjct: 2289 LTECHDIRQGPCFAEVLQTMCRSLSSS 2315
Score = 137 bits (346), Expect = 1e-32
Identities = 84/239 (35%), Positives = 106/239 (44%), Gaps = 11/239 (4%)
Query: 102 PAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE 161
P+ + C GY D + C+DVDEC + C DC N+PG+Y C C G++
Sbjct: 428 PSSYRCECNVGYTQDVRGECIDVDECTSS--PCHHG-DCVNIPGTYHCRCYPGFQATPTR 484
Query: 162 --CVDIDECRYR--YCQ-HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQR 216
CVD+DEC C RCVN GSF+C C GF+L P+ ++CVD NEC C
Sbjct: 485 QACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNG 544
Query: 217 -CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQL 275
C N G+F C C G+ L G C DIDEC C N G F C C G +
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAV 604
Query: 276 -LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASN 333
R+C D S + E +C G C P E LCPA +
Sbjct: 605 GTDGRVCVD-THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKD 662
Score = 126 bits (316), Expect = 5e-29
Identities = 108/353 (30%), Positives = 142/353 (40%), Gaps = 62/353 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIND-------- 90
C G++ D C D++EC P C G C N G Y CL V+
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQP--C-GNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFD 1888
Query: 91 ----LHGE----GPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCH 141
L G+ G + H C G+E D +CVD +EC C P C
Sbjct: 1889 ECTTLVGQVCRFGHCLNTAGSFHCL-CQDGFELTADGKNCVDTNECLSLAGTCLPGT-CQ 1946
Query: 142 NLPGSYQCTCPDGYRKIGPECVDIDECRYR--YCQH-RCVNLPGSFRCQCEPGFQLGPNN 198
NL GS++C CP G++ C+DIDEC C C N PGSF+C C PGF L N
Sbjct: 1947 NLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNG 2006
Query: 199 RSCVDVNEC------DMGAPCEQRCFNSYGTFLC---RCHQGY----------------E 233
C D + + G + FN+ T C R +G+ E
Sbjct: 2007 HRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQE 2066
Query: 234 LHRDGF--------SCSDIDECSYSSYLCQYR-CVNEPGRFSCHCPQGYQLLATRL-CQD 283
L G S D++EC+ + +C CVN G F C CP GY L T + C D
Sbjct: 2067 LCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Query: 284 IDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLC 336
DEC G H C + TC N GG+ C + + E+ C + LC
Sbjct: 2127 TDECSVG-HPCGQG-TCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLC 2177
Score = 123 bits (309), Expect = 3e-28
Identities = 109/375 (29%), Positives = 147/375 (39%), Gaps = 88/375 (23%)
Query: 16 ALLLLLLGSASPQDSEEPDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINH 74
AL LL + Q+S P SY+ C G+ + D++ C+DV+ECL+ P C + C N
Sbjct: 729 ALNSLLCDNGWCQNS--PGSYSCSCPPGFHFWQDTEICKDVDECLSSP--CVSGV-CRNL 783
Query: 75 YGGYLC--------------------------LPRSAAVIN-----------DLHGEGPP 97
G Y C + S +N G
Sbjct: 784 AGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWG 843
Query: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR- 156
P + C G+ +C DV+EC C P+ C N GS++C CP+G
Sbjct: 844 SPCERCEIDPACARGFARMTGVTCDDVNECESFPGVC-PNGRCVNTAGSFRCECPEGLML 902
Query: 157 -KIGPECVDI--DECRYRYCQHRC-VNLPGSFR---CQCEPGFQLGPNNRSC-------- 201
G CVD+ + C R+ + C V LPG +R C C G G +C
Sbjct: 903 DASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEF 962
Query: 202 ----------------------VDVNECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRD 237
DVNEC + G C N+ G+F C C G+ L
Sbjct: 963 ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
Query: 238 GFSCSDIDECSYSSYLC-QYRCVNEPGRFSCHCPQGYQ--LLATRLCQDIDECESGAHQC 294
+C+DIDEC S LC Q CVN PG F C C GY+ + + C D+DEC C
Sbjct: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLC 1082
Query: 295 SEAQTCVNFHGGYRC 309
TC N G Y+C
Sbjct: 1083 -RGGTCTNTDGSYKC 1096
Score = 111 bits (278), Expect = 1e-24
Identities = 93/352 (26%), Positives = 127/352 (36%), Gaps = 111/352 (31%)
Query: 36 YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEG 95
+ C G++ P Q C DV+EC+ C +C+N G + C+
Sbjct: 471 HCRCYPGFQATPTRQACVDVDECIVSGGLCH-LGRCVNTEGSFQCV-------------- 515
Query: 96 PPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG 154
C G+E D +CVD +ECA + + C N GS+ C C G
Sbjct: 516 -------------CNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSCLCKPG 560
Query: 155 YRKI--GPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDV------ 204
+ G C+DIDEC+ C + C N GSFRCQC G +G + R CVD
Sbjct: 561 FLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTC 620
Query: 205 -------------------NEC-------DMGAPCEQRCFNSYGTFLCRCHQGYELHRD- 237
+EC G PC+ F C G + D
Sbjct: 621 YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG 680
Query: 238 --------------------------------------GFSCSDIDECSYSSYLCQYR-C 258
G C+D+DEC+ +S LC C
Sbjct: 681 RDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC 740
Query: 259 VNEPGRFSCHCPQGYQLLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
N PG +SC CP G+ T +C+D+DEC S + C N G Y C
Sbjct: 741 QNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP---CVSGVCRNLAGSYTC 789
Score = 108 bits (270), Expect = 1e-23
Identities = 89/308 (28%), Positives = 124/308 (40%), Gaps = 46/308 (14%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK---CINHYGGYLCLPRSAAVINDLHGE 94
+C G D + C D + + C G ++ C + G + D HG
Sbjct: 597 QCLGGLAVGTDGRVCVDTH----VRSTCYGAIEKGSCARPFPGTVTKSECCCANPD-HGF 651
Query: 95 GPPPPVPPAQHPNP----CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT 150
G P + PA+ C G D++ECA C C NL GSY+C
Sbjct: 652 GEPCQLCPAKDSAEFQALCSSGLGITTDGR--DINECALDPEVCANGV-CENLRGSYRCV 708
Query: 151 CPDGYRK--IGPECVDIDECRYR--YCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205
C GY G +C D+DEC C + C N PGS+ C C PGF + C DV+
Sbjct: 709 CNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVD 768
Query: 206 ECDMGAPCEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRC-VNEPG 263
EC + +PC C N G++ C+C G L G C D + + + + RC VN G
Sbjct: 769 EC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG 827
Query: 264 ---RFSC-------------------HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCV 301
R C C +G+ + C D++ECES C + CV
Sbjct: 828 ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGR-CV 886
Query: 302 NFHGGYRC 309
N G +RC
Sbjct: 887 NTAGSFRC 894
Score = 108 bits (269), Expect = 1e-23
Identities = 92/310 (29%), Positives = 135/310 (43%), Gaps = 32/310 (10%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PRSAAVINDLHGEGP 96
EC GY ++ C D++EC T C G C N G Y C+ P +N +
Sbjct: 1589 ECPPGYHLSEHTRICEDIDECSTHSGIC-GPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD 1647
Query: 97 PPPVPPAQHPN-PCPPGYEPD-DQDSCVDVDECAQALHDCRPSQDCHN-LPGSYQCTCPD 153
+H N C + + C QA + RP + C + YQ C
Sbjct: 1648 MRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN--RPCEACPTPISPDYQILC-- 1703
Query: 154 GYRKIG-------PECVDIDECRY--RYCQHR-CVNLPGSFRCQCEPGFQLGPNNRSCVD 203
G + G + +DIDEC C + C+N GSFRC+C GF +C D
Sbjct: 1704 GNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACED 1763
Query: 204 VNEC-DMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY-RCV 259
V+EC +PC+Q C N G++ C+C +GY+L G +C +EC +C + C+
Sbjct: 1764 VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCM 1822
Query: 260 NEPGRFSCHCPQGYQLLATR-LCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
+ G + C C +G+Q A + LC DIDEC+ C TC N G Y C+ C
Sbjct: 1823 DTEGSYMCLCHRGFQASADQTLCMDIDECD--RQPCGNG-TCKNIIGSYNCL----CFPG 1875
Query: 319 YIQVSENRCL 328
++ C+
Sbjct: 1876 FVVTHNGDCV 1885
Score = 86.7 bits (213), Expect = 4e-17
Identities = 89/370 (24%), Positives = 130/370 (35%), Gaps = 100/370 (27%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P S++ C G W D C D++EC++ C C+N G Y C R +
Sbjct: 1301 PGSFSCRCLPG--WVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF 1358
Query: 92 HGEGPPPPVP-------------PAQHPNPCPPGYEP-DDQDSCVDVDECAQA------- 130
E P + C G++P +D +C DVDECAQ
Sbjct: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
Query: 131 ---------------------------LHDCRPSQDCHN-----LPGSYQCTCPDGYR-- 156
+++C +C N PGSY C+CP +
Sbjct: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478
Query: 157 KIGPECVD-------------------------IDECRYRYC-------QHRCVNLPGS- 183
G CVD + R C + C P +
Sbjct: 1479 PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMAN 1538
Query: 184 ---FRCQCEPGFQLGPNNRSCV--DVNEC-DMGAPCEQR-CFNSYGTFLCRCHQGYELHR 236
+R C G PN + + D++EC ++ C+ C N++G+F C C GY L
Sbjct: 1539 TTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598
Query: 237 DGFSCSDIDECSYSSYLC-QYRCVNEPGRFSCHCPQGY-QLLATRLCQDIDECESGAHQC 294
C DIDECS S +C C N G ++C CP Y Q+ C D+ + H
Sbjct: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658
Query: 295 SEAQTCVNFH 304
Q + F+
Sbjct: 1659 GTCQNELAFN 1668
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/161 (31%), Positives = 65/161 (40%), Gaps = 38/161 (23%)
Query: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
EC G+ C DVNEC P C + C N GGY C
Sbjct: 2512 ECHQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQLGGYRC----------------- 2551
Query: 98 PPVPPAQHPNPCPPGYEPDDQ-DSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY- 155
CP G+ Q CVD +ECA + C S C N G ++C CP G+
Sbjct: 2552 ----------SCPQGFTQHSQWAQCVDENECALSPPTC-GSASCRNTLGGFRCVCPSGFD 2600
Query: 156 --RKIGPECVDIDECRYRY--CQHRCVNLPGSFRCQCEPGF 192
+ +G C ++DEC R C + C N PG F C C G+
Sbjct: 2601 FDQALG-GCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
Score = 73.9 bits (180), Expect = 3e-13
Identities = 97/402 (24%), Positives = 134/402 (33%), Gaps = 108/402 (26%)
Query: 4 CASCLPGSLLLWALLLLLLGSASPQDSEE-PDSYTECTDGYEWDPDSQHCRDVNECLTIP 62
C L G + AL +G A E P C G+ + + C+DV+EC +P
Sbjct: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
Query: 63 EACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYE-PDDQDSC 121
C+G C+N G + C CP G+ D +C
Sbjct: 256 GLCQGG-SCVNMVGSFHC---------------------------RCPVGHRLSDSSAAC 287
Query: 122 VD--VDECAQALHDCRPSQDCHNLPGSY---QCTCPDGYRKIGPECVDIDECR-----YR 171
D C L R + D L G Y QC C G ++ R +
Sbjct: 288 EDYRAGACFSVLFGGRCAGD---LAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
Query: 172 YCQHRCVNLPGSFRCQCEPGF--------------------------------QLGPNN- 198
C R LPG PG LGP N
Sbjct: 345 LCAQRLPLLPG------HPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNS 398
Query: 199 -------RSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSS 251
+D+ RC + ++ C C+ GY G C D+DEC+ S
Sbjct: 399 NIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG-ECIDVDECTSSP 457
Query: 252 YLCQY-RCVNEPGRFSCHCPQGYQLLATR-LCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C + CVN PG + C C G+Q TR C D+DEC C + CVN G ++C
Sbjct: 458 --CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSFQC 514
Query: 310 V---------DTNRCVEPYIQVSENRCLCPASNPLCREQPSS 342
V D CV+ + C+ N +C + S
Sbjct: 515 VCNAGFELSPDGKNCVDHNECATSTMCV----NGVCLNEDGS 552
Score = 52.8 bits (125), Expect = 6e-07
Identities = 50/167 (29%), Positives = 68/167 (40%), Gaps = 33/167 (19%)
Query: 127 CAQALHDCRPSQDCHN---LPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGS 183
C Q + D + CHN G +C C G+ +GP+C E YR C G
Sbjct: 146 CGQPICD----RGCHNGGRCIGPNRCACVYGF--MGPQC----ERDYR--TGPCFGQVGP 193
Query: 184 FRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCR-----CHQGYELHRDG 238
CQ + + C V G PCE LC C +G+ +
Sbjct: 194 EGCQHQLTGLVCTKALCCATVGRA-WGLPCE----------LCPAQPHPCRRGFIPNIHT 242
Query: 239 FSCSDIDECSYSSYLCQY-RCVNEPGRFSCHCPQGYQLL-ATRLCQD 283
+C D+DEC LCQ CVN G F C CP G++L ++ C+D
Sbjct: 243 GACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289
Score = 43.1 bits (100), Expect = 5e-04
Identities = 62/229 (27%), Positives = 86/229 (37%), Gaps = 52/229 (22%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDEC 168
C PG+ S V C +A + SQ NL CTC DG + P C
Sbjct: 68 CCPGWRTFPGRSQCVVPICRRACGEGFCSQP--NL-----CTCADG--TLAPSC---GVS 115
Query: 169 RYRYCQHRCVNLPGSFR---CQCEPGFQ-------------------LGPNNRSCVDVNE 206
R C C+N G+ R C C+ G+ +GPN +CV
Sbjct: 116 RGSGCSVSCMN-GGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACV---Y 171
Query: 207 CDMGAPCEQR-----CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNE 261
MG CE+ CF G C+ HQ G C+ C+ C
Sbjct: 172 GFMGPQCERDYRTGPCFGQVGPEGCQ-HQ-----LTGLVCTKALCCATVGRAWGLPCELC 225
Query: 262 PGRFSCHCPQGY-QLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
P + C +G+ + T CQD+DEC++ C + +CVN G + C
Sbjct: 226 PAQ-PHPCRRGFIPNIHTGACQDVDECQAVPGLC-QGGSCVNMVGSFHC 272
Score = 29.3 bits (64), Expect = 7.5
Identities = 41/156 (26%), Positives = 54/156 (34%), Gaps = 43/156 (27%)
Query: 181 PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTF---------LCR--CH 229
PG R + PG GPN G+ C + TF +CR C
Sbjct: 42 PGRVRRRGSPGILQGPNV----------CGSRFHAYCCPGWRTFPGRSQCVVPICRRACG 91
Query: 230 QGYELHRDGFSCSD---IDECSYSSYL-CQYRCVNEPG--RFSCHCPQGYQLLATRLCQD 283
+G+ + +C+D C S C C+N SC C +GY T Q
Sbjct: 92 EGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT--GTVCGQP 149
Query: 284 IDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY 319
I C+ G H G RC+ NRC Y
Sbjct: 150 I--CDRGCHN------------GGRCIGPNRCACVY 171
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 169 bits (428), Expect = 5e-42
Identities = 113/372 (30%), Positives = 159/372 (42%), Gaps = 77/372 (20%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY+ + C DVNEC C+ + C N GGY C+ DL
Sbjct: 5217 CEPGYQLK--GRKCMDVNECRQ--NVCRPDQHCKNTRGGYKCI--------DL------- 5257
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK- 157
CP G + +C+D+DEC H CR +Q C N GSY+C CP GYR
Sbjct: 5258 ----------CPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQ 5307
Query: 158 -IGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPC 213
+G C+DI+EC + C H+C N PGSF+C C PG L + +SC + + G
Sbjct: 5308 GVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQY 5367
Query: 214 E-----------------------QRCFNSYG------TFLCR--------CHQGYELHR 236
++SY T L R C +G E
Sbjct: 5368 SSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASH 5427
Query: 237 DGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQDIDECESGAHQCS 295
D +C DIDEC ++ CQ+ C N G + C CP GYQL + CQDIDEC C
Sbjct: 5428 D--TCVDIDECE-NTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCG 5484
Query: 296 EAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL--CPASNPLCREQPSSIVHRYMTITSE 353
+ C N G Y+C+DT CL CP ++ C P ++ ++ +++
Sbjct: 5485 PNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFG 5544
Query: 354 RSVPADVFQIQA 365
+ D+ ++ A
Sbjct: 5545 IATNQDLIRLVA 5556
Score = 163 bits (413), Expect = 3e-40
Identities = 100/263 (38%), Positives = 122/263 (46%), Gaps = 39/263 (14%)
Query: 107 NPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG--YRKIGPECV 163
N CP G+ D C D DECA A + C S CHN G+Y C+CP G G C
Sbjct: 5090 NQCPSGFTLDSVGPFCADEDECA-AGNPC--SHSCHNAMGTYYCSCPKGLTIAADGRTCQ 5146
Query: 164 DIDECRY-RYCQHR---CVNLPGSFRC--QCEPGFQLGPNNRSCVDVNECDMGAPCEQRC 217
DIDEC R+ H C N GS+RC +C GF+ + SC D+NEC +PC QRC
Sbjct: 5147 DIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRC 5206
Query: 218 FNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSC--HCPQGYQL 275
FN+ G+F C C GY+L G C D++EC + C N G + C CP G
Sbjct: 5207 FNAIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTK 5264
Query: 276 LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV---------------DTNRCVE--- 317
C DIDEC+ G HQC Q C N G YRCV D N C +
Sbjct: 5265 AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPK 5324
Query: 318 PYIQVSEN-----RCLCPASNPL 335
P N +C+CP L
Sbjct: 5325 PCAHQCSNTPGSFKCICPPGQHL 5347
Score = 141 bits (356), Expect = 1e-33
Identities = 106/378 (28%), Positives = 152/378 (40%), Gaps = 77/378 (20%)
Query: 36 YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEG 95
Y C G D + C+D++EC C C N G Y C+ R +
Sbjct: 5129 YCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGL 5188
Query: 96 PPPPVPPAQHPNP---------------CPPGYEPDDQDSCVDVDECAQALHDCRPSQDC 140
+ Q +P C PGY+ + C+DV+EC Q + CRP Q C
Sbjct: 5189 SCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGR-KCMDVNECRQNV--CRPDQHC 5245
Query: 141 HNLPGSYQC--TCPDGYRKI-GPECVDIDECR--YRYCQHR--CVNLPGSFRCQCEPGFQ 193
N G Y+C CP+G K C+DIDEC+ C++ C N GS+RC C G++
Sbjct: 5246 KNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYR 5305
Query: 194 LGPNNRSCVDVNECD-MGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDE-----C 247
R C+D+NEC+ + PC +C N+ G+F C C G L DG SC+ ++
Sbjct: 5306 SQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGT 5365
Query: 248 SYSSY-LCQYRCVNEPGRFSCH-------------------------------CPQGYQL 275
YSSY L ++ V + H CP+G +
Sbjct: 5366 QYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSE- 5424
Query: 276 LATRLCQDIDECES------------GAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVS 323
+ C DIDECE+ G++QC H G C D + C+E +
Sbjct: 5425 ASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCG 5484
Query: 324 ENR-CLCPASNPLCREQP 340
NR C + C + P
Sbjct: 5485 PNRMCFNMRGSYQCIDTP 5502
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 162 bits (411), Expect = 4e-40
Identities = 114/332 (34%), Positives = 146/332 (43%), Gaps = 67/332 (20%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
PD Y C+ GY+ P +C D NECL P CKG+ +CIN G Y C
Sbjct: 865 PDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCF---------- 912
Query: 92 HGEGPPPPVPPAQHPNPCPPGYE---PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148
C PGY C D++EC Q C Q C N GSY
Sbjct: 913 -----------------CYPGYTLATSGATQECQDINECEQP-GVCSGGQ-CTNTEGSYH 953
Query: 149 CTCPDGYRKIGP-ECVDIDECRYRYC--QHRCVNLPGSFRC-QCEPGFQLGPNNRSCVDV 204
C C GY + C DI+ECR+ RCVN PGS+ C CE G++ + SCVDV
Sbjct: 954 CECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDV 1011
Query: 205 NECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG 263
NEC C +C N G+F C C QGYE+ D C D+DEC+ + C+N G
Sbjct: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEG 1071
Query: 264 RFSCH-CPQGYQLLAT-RLCQDIDE------CESG-AHQCSEAQTCVNFHGGYR------ 308
F+C C GY + C+D+DE C SG + + +C + GGYR
Sbjct: 1072 SFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGD 1131
Query: 309 -CVDTNRCVEPYIQ---------VSENRCLCP 330
C D + C +P V +CLCP
Sbjct: 1132 SCEDVDECEDPQSSCLGGECKNTVGSYQCLCP 1163
Score = 151 bits (382), Expect = 1e-36
Identities = 110/308 (35%), Positives = 132/308 (42%), Gaps = 40/308 (12%)
Query: 33 PDSYT--ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLC-LPRSAAVIN 89
P SYT C +GY S C DVNECLT P C KC N G + C + V +
Sbjct: 989 PGSYTCLACEEGYRGQSGS--CVDVNECLT-PGVC-AHGKCTNLEGSFRCSCEQGYEVTS 1044
Query: 90 DLHGEGPPPPVPPAQHPNPCPPG------------------YEPDDQDSCVDVDECAQAL 131
D G V CP G + +D +C D+DECA
Sbjct: 1045 DEKG---CQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA--F 1099
Query: 132 HDCRPSQDCHNLPGSYQCT-CPDGYRK--IGPECVDIDECRYRYCQ---HRCVNLPGSFR 185
PS C N GS+ C C GYR +G C D+DEC C N GS++
Sbjct: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
Query: 186 CQCEPGFQLGPNNRSCVDVNECDMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSD 243
C C GFQL N C DVNEC C C NS+G+F C C G+ G SC D
Sbjct: 1160 CLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
Query: 244 IDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ-LLATRLCQDIDECESGAHQCSEAQTCVN 302
+DEC+ + CVN G F+C C G+Q + C DIDECE C N
Sbjct: 1219 VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCEN 1278
Query: 303 FHGGYRCV 310
G YRCV
Sbjct: 1279 SPGSYRCV 1286
Score = 146 bits (369), Expect = 3e-35
Identities = 96/287 (33%), Positives = 128/287 (44%), Gaps = 42/287 (14%)
Query: 35 SYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE 94
S +C GY P C DV+EC +C G +C N G Y CL
Sbjct: 1116 SCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG-ECKNTVGSYQCL------------- 1161
Query: 95 GPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG 154
CP G++ + C DV+EC H C P +C N GS+ C C G
Sbjct: 1162 --------------CPQGFQLANGTVCEDVNECMGEEH-CAPHGECLNSHGSFFCLCAPG 1206
Query: 155 YRKI--GPECVDIDECRYR--YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DM 209
+ G C D+DEC CVN GSF C CE GFQ P + CVD++EC D
Sbjct: 1207 FVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDY 1266
Query: 210 GAPC--EQRCFNSYGTFLC--RCHQGYELHRDGFSCSDIDECSYSSYLCQYR-CVNEPGR 264
G P +C NS G++ C C G+ + +G C DIDEC+ + + C N G
Sbjct: 1267 GDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGS 1325
Query: 265 FSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
F C C QG+++ + C D++ECE C A C N G + C+
Sbjct: 1326 FRCLCDQGFEISPSGWDCVDVNECELMLAVCG-AALCENVEGSFLCL 1371
Score = 123 bits (308), Expect = 4e-28
Identities = 75/213 (35%), Positives = 110/213 (51%), Gaps = 20/213 (9%)
Query: 124 VDECAQ-ALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE---CVDIDECRYRYC--QHRC 177
+D CA A + C P C NLP Y+C C GY ++ P C D +EC C + RC
Sbjct: 845 IDRCAAGATNVCGPGT-CVNLPDGYRCVCSPGY-QLHPSQAYCTDDNECLRDPCKGKGRC 902
Query: 178 VNLPGSFRCQCEPGFQLGPN--NRSCVDVNECDMGAPCE-QRCFNSYGTFLCRCHQGYEL 234
+N GS+ C C PG+ L + + C D+NEC+ C +C N+ G++ C C QGY +
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
Query: 235 HRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSC-HCPQGYQLLATRLCQDIDECESGAHQ 293
R G C DI+EC + RCVN PG ++C C +GY+ + C D++EC +
Sbjct: 963 VRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLTPG-V 1019
Query: 294 CSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR 326
C+ + C N G +RC C + Y S+ +
Sbjct: 1020 CAHGK-CTNLEGSFRC----SCEQGYEVTSDEK 1047
Score = 107 bits (266), Expect = 3e-23
Identities = 73/218 (33%), Positives = 97/218 (44%), Gaps = 25/218 (11%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAV-------INDL 91
C G++ + C DVNEC+ E C +C+N +G + CL V D+
Sbjct: 1162 CPQGFQL-ANGTVCEDVNECMG-EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDV 1219
Query: 92 HGEGPPPPVPPAQHPNP-------CPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNL 143
P N C G++P + CVD+DEC + C N
Sbjct: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENS 1279
Query: 144 PGSYQCT--CPDGYRKI-GPECVDIDECRY-RYCQHR--CVNLPGSFRCQCEPGFQLGPN 197
PGSY+C C G+ +C+DIDEC C C N GSFRC C+ GF++ P+
Sbjct: 1280 PGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPS 1339
Query: 198 NRSCVDVNECD-MGAPC-EQRCFNSYGTFLCRCHQGYE 233
CVDVNEC+ M A C C N G+FLC C E
Sbjct: 1340 GWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLE 1377
Score = 77.4 bits (189), Expect = 2e-14
Identities = 44/114 (38%), Positives = 55/114 (48%), Gaps = 9/114 (7%)
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N + C C GY+LH C+D +EC + RC+N G +SC C GY L
Sbjct: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920
Query: 277 ---ATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRC 327
AT+ CQDI+ECE CS Q C N G Y C C + YI V + C
Sbjct: 921 TSGATQECQDINECEQPG-VCSGGQ-CTNTEGSYHC----ECDQGYIMVRKGHC 968
Score = 63.5 bits (153), Expect = 4e-10
Identities = 77/306 (25%), Positives = 104/306 (33%), Gaps = 62/306 (20%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL----------------P 82
C G+E P C DVNEC + C G C N G +LCL P
Sbjct: 1330 CDQGFEISPSGWDCVDVNECELMLAVC-GAALCENVEGSFLCLCASDLEEYDAQEGHCRP 1388
Query: 83 RSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCR------- 135
R A E P PA C G + S V QA C
Sbjct: 1389 RGAG--GQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGD 1446
Query: 136 -----PSQDCHNLPGSYQCTCPDGYRKIGPE---------CVDIDECRY---RYCQH-RC 177
PS+D + CP G I E D DEC C + RC
Sbjct: 1447 ACDLCPSEDS----AEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRC 1502
Query: 178 VNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRD 237
+N + C C PGF +++ C D +EC A C N+ G+F C C L
Sbjct: 1503 LNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLS 1562
Query: 238 GFSC-------SDIDECSYSSYLCQYRCVNEPGRFSCHCP-QGYQLLATRLCQDIDECES 289
C D+ + +C + N+ C P +G++ T C + E+
Sbjct: 1563 QQRCMNSTSSTEDLPDHDIHMDICWKKVTND----VCSEPLRGHRTTYTECC--CQDGEA 1616
Query: 290 GAHQCS 295
+ QC+
Sbjct: 1617 WSQQCA 1622
Score = 60.1 bits (144), Expect = 4e-09
Identities = 53/202 (26%), Positives = 77/202 (38%), Gaps = 33/202 (16%)
Query: 96 PPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSY-------- 147
PP P+PPA P P G + V+ +CA L + +DC G++
Sbjct: 536 PPRPLPPAA---PRPRGLLGRCYLNTVN-GQCANPLLELTTQEDCCGSVGAFWGVTLCAP 591
Query: 148 -------------QCTCPDGYRKIG-PECVDIDEC-RYRYCQH-RCVNLPGSFRCQCEPG 191
Q CP GY+++ C DI+EC C+ CVN GS+ C C PG
Sbjct: 592 CPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG 651
Query: 192 FQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSS 251
L P+ CV M + C+ S G C + + CS + + S
Sbjct: 652 LMLDPSRSRCVSDKAISM---LQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE 708
Query: 252 YLCQYRCVNEPGRFSCHCPQGY 273
C+ + F CP G+
Sbjct: 709 --CEKCPLPGTEAFREICPAGH 728
Score = 53.1 bits (126), Expect = 5e-07
Identities = 30/81 (37%), Positives = 42/81 (51%), Gaps = 7/81 (8%)
Query: 159 GPECVDIDECRY-RYCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPC-- 213
G E + +EC C++ RCV + + C C GFQL + +CVDVNEC D+ P
Sbjct: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL 1787
Query: 214 --EQRCFNSYGTFLCRCHQGY 232
C N+ G++ C C GY
Sbjct: 1788 CVHGYCENTEGSYRCHCSPGY 1808
Score = 47.8 bits (112), Expect = 2e-05
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 10/87 (11%)
Query: 191 GFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC--- 247
GF+ G C +N C+ G RC + C C +G++L +C D++EC
Sbjct: 1728 GFE-GLQAEECGILNGCENG-----RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
Query: 248 SYSSYLCQY-RCVNEPGRFSCHCPQGY 273
+ + LC + C N G + CHC GY
Sbjct: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 43.1 bits (100), Expect = 5e-04
Identities = 24/75 (32%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 15 WALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINH 74
W + L P + EC GY+ + HC+D+NECLT+ CK + +C+N
Sbjct: 584 WGVTLCAPCPPRPASPVIENGQLECPQGYK-RLNLTHCQDINECLTL-GLCK-DAECVNT 640
Query: 75 YGGYLCLPRSAAVIN 89
G YLC R +++
Sbjct: 641 RGSYLCTCRPGLMLD 655
Score = 43.1 bits (100), Expect = 5e-04
Identities = 67/306 (21%), Positives = 103/306 (33%), Gaps = 51/306 (16%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G+ +D + C D +EC + AC+ +C+N G + C PP
Sbjct: 1513 CNPGFHYDASHKKCEDHDECQDL--ACENG-ECVNTEGSFHCFC------------SPPL 1557
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSY-QCTCPDGYRK 157
+ +Q D D + +D C + + + S+ +Y +C C DG
Sbjct: 1558 TLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-EA 1616
Query: 158 IGPECV----DIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPC 213
+C E + C + PG++ GP GAP
Sbjct: 1617 WSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPF 1676
Query: 214 -----------EQRCFNSYGTFLCRCH------QGYELHRD----------GFSCSDIDE 246
E N+ G R Q EL GF +E
Sbjct: 1677 YNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEE 1736
Query: 247 CSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL-CQDIDECE--SGAHQCSEAQTCVNF 303
C + RCV ++C C +G+QL A + C D++EC+ +G C N
Sbjct: 1737 CGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENT 1796
Query: 304 HGGYRC 309
G YRC
Sbjct: 1797 EGSYRC 1802
Score = 40.4 bits (93), Expect = 0.003
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 7/61 (11%)
Query: 269 CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCL 328
CPQGY+ L CQDI+EC + C +A+ CVN G Y C P + + +R
Sbjct: 608 CPQGYKRLNLTHCQDINECLT-LGLCKDAE-CVNTRGSYLCT-----CRPGLMLDPSRSR 660
Query: 329 C 329
C
Sbjct: 661 C 661
Score = 36.2 bits (82), Expect = 0.061
Identities = 21/64 (32%), Positives = 27/64 (42%), Gaps = 5/64 (7%)
Query: 275 LLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNP 334
+L T ID C +GA TCVN GYRCV P Q+ ++ C N
Sbjct: 836 VLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCV-----CSPGYQLHPSQAYCTDDNE 890
Query: 335 LCRE 338
R+
Sbjct: 891 CLRD 894
Score = 33.5 bits (75), Expect = 0.40
Identities = 28/103 (27%), Positives = 37/103 (35%), Gaps = 13/103 (12%)
Query: 228 CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDEC 287
C QGY+ + C DI+EC CVN G + C C G L +R C
Sbjct: 608 CPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSR-----SRC 661
Query: 288 ESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQ-VSENRCLC 329
S C YR + C P Q +++ C C
Sbjct: 662 VSDKAISMLQGLC------YRSLGPGTCTLPLAQRITKQICCC 698
Score = 31.2 bits (69), Expect = 2.0
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 13/55 (23%)
Query: 109 CPPGYEPDDQD-SCVDVDECAQ-------ALHDCRPSQDCHNLPGSYQCTCPDGY 155
C G++ D +CVDV+EC +H C N GSY+C C GY
Sbjct: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-----CENTEGSYRCHCSPGY 1808
Score = 30.4 bits (67), Expect = 3.4
Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 3/50 (6%)
Query: 34 DSYT-ECTDGYEWDPDSQHCRDVNEC--LTIPEACKGEMKCINHYGGYLC 80
+ YT +C +G++ D C DVNEC L P C N G Y C
Sbjct: 1753 EGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRC 1802
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 157 bits (398), Expect = 1e-38
Identities = 92/298 (30%), Positives = 140/298 (46%), Gaps = 49/298 (16%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P S+ +C GY D + C V+ C + C+ E C+N G YLC +N
Sbjct: 298 PGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNP- 354
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
D+ +C +D CA + H C+ +C N SY C C
Sbjct: 355 -------------------------DKKTCTKIDYCASSNHGCQ--HECVNTDDSYSCHC 387
Query: 152 PDGYRKIGPE---CVDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
G+ + P+ C I+ C C+H CVN+ S+ C+C G+ L PN ++C V+
Sbjct: 388 LKGFT-LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDH 446
Query: 207 C---DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG 263
C D G CEQ C N+ +F+C+C +G+ ++ D +CS +D C S + C+Y CVN
Sbjct: 447 CAQQDHG--CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDR 504
Query: 264 RFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI 320
F+C CP+G+ L + + C +D C G H C +CV+ + C +C E YI
Sbjct: 505 SFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVC----QCFEGYI 556
Score = 148 bits (373), Expect = 1e-35
Identities = 91/291 (31%), Positives = 130/291 (44%), Gaps = 33/291 (11%)
Query: 58 CLTIPEACKGEMKCINHYGGYLCLPRSAAVIN---------DL-----HGEGPPPPVPPA 103
C T+ C CIN G Y+C + ++N DL H P
Sbjct: 242 CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 104 QHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE- 161
C GY +D CV VD CA H C +C N GSY C C +G+ + P+
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLCQCHEGF-ALNPDK 356
Query: 162 --CVDIDEC--RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP-CEQR 216
C ID C CQH CVN S+ C C GF L P+ ++C +N C + P CE
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N ++ CRCH+GY L +G +CS +D C+ + C+ C+N F C C +G+ +
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 277 A-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR 326
+ C +D C H C +CVN + C +C E ++ S+ +
Sbjct: 477 EDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFAC----QCPEGHVLRSDGK 521
Score = 145 bits (367), Expect = 5e-35
Identities = 98/338 (28%), Positives = 147/338 (43%), Gaps = 53/338 (15%)
Query: 34 DSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLH 92
DSY+ C G+ +PD + CR +N C C+ E C+N Y C
Sbjct: 381 DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE--CVNMEESYYCR----------- 427
Query: 93 GEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
C GY D +C VD CAQ H C Q C N S+ C C
Sbjct: 428 ----------------CHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQC 469
Query: 152 PDGY--RKIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
+G+ + C +D C C++ CVN+ SF CQC G L + ++C ++ C
Sbjct: 470 SEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSC 529
Query: 208 DMGAP-CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFS 266
+G CE C +S +F+C+C +GY L DG +C D C + C++ CVN ++
Sbjct: 530 ALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT 589
Query: 267 CHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
C C +G++L + C+ D C+S H C CVN Y C +C E ++ +
Sbjct: 590 CECLEGFRLAEDGKRCRRKDVCKSTHHGCE--HICVNNGNSYIC----KCSEGFVLAEDG 643
Query: 326 RCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQI 363
R C C E P +V I +S+ + F++
Sbjct: 644 R-RCKK----CTEGPIDLV---FVIDGSKSLGEENFEV 673
Score = 123 bits (308), Expect = 4e-28
Identities = 72/249 (28%), Positives = 106/249 (42%), Gaps = 35/249 (14%)
Query: 32 EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
E Y C GY DP+ + C V+ C C E C+N ++C +IN
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLIN-- 476
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
+D +C VD C + H C S C N+ S+ C C
Sbjct: 477 ------------------------EDLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQC 510
Query: 152 PDGY--RKIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
P+G+ R G C +D C C+H CV+ SF CQC G+ L + ++C + C
Sbjct: 511 PEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
Query: 208 D-MGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFS 266
+ CE C NS ++ C C +G+ L DG C D C + + C++ CVN +
Sbjct: 571 QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
Query: 267 CHCPQGYQL 275
C C +G+ L
Sbjct: 631 CKCSEGFVL 639
Score = 38.1 bits (87), Expect = 0.016
Identities = 31/127 (24%), Positives = 40/127 (31%), Gaps = 32/127 (25%)
Query: 30 SEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIN 89
S E +C +GY D + CR + C I C E C+N Y C
Sbjct: 542 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTC--------- 590
Query: 90 DLHGEGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148
C G+ +D C D C H C C N SY
Sbjct: 591 ------------------ECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYI 630
Query: 149 CTCPDGY 155
C C +G+
Sbjct: 631 CKCSEGF 637
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 157 bits (398), Expect = 1e-38
Identities = 92/298 (30%), Positives = 140/298 (46%), Gaps = 49/298 (16%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P S+ +C GY D + C V+ C + C+ E C+N G YLC +N
Sbjct: 298 PGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNP- 354
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
D+ +C +D CA + H C+ +C N SY C C
Sbjct: 355 -------------------------DKKTCTKIDYCASSNHGCQ--HECVNTDDSYSCHC 387
Query: 152 PDGYRKIGPE---CVDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
G+ + P+ C I+ C C+H CVN+ S+ C+C G+ L PN ++C V+
Sbjct: 388 LKGFT-LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDH 446
Query: 207 C---DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG 263
C D G CEQ C N+ +F+C+C +G+ ++ D +CS +D C S + C+Y CVN
Sbjct: 447 CAQQDHG--CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDR 504
Query: 264 RFSCHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI 320
F+C CP+G+ L + + C +D C G H C +CV+ + C +C E YI
Sbjct: 505 SFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVC----QCFEGYI 556
Score = 148 bits (373), Expect = 1e-35
Identities = 91/291 (31%), Positives = 130/291 (44%), Gaps = 33/291 (11%)
Query: 58 CLTIPEACKGEMKCINHYGGYLCLPRSAAVIN---------DL-----HGEGPPPPVPPA 103
C T+ C CIN G Y+C + ++N DL H P
Sbjct: 242 CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 104 QHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE- 161
C GY +D CV VD CA H C +C N GSY C C +G+ + P+
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLCQCHEGF-ALNPDK 356
Query: 162 --CVDIDEC--RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP-CEQR 216
C ID C CQH CVN S+ C C GF L P+ ++C +N C + P CE
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 217 CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL 276
C N ++ CRCH+GY L +G +CS +D C+ + C+ C+N F C C +G+ +
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 277 A-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENR 326
+ C +D C H C +CVN + C +C E ++ S+ +
Sbjct: 477 EDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFAC----QCPEGHVLRSDGK 521
Score = 145 bits (367), Expect = 5e-35
Identities = 98/338 (28%), Positives = 147/338 (43%), Gaps = 53/338 (15%)
Query: 34 DSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLH 92
DSY+ C G+ +PD + CR +N C C+ E C+N Y C
Sbjct: 381 DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE--CVNMEESYYCR----------- 427
Query: 93 GEGPPPPVPPAQHPNPCPPGYEPDDQD-SCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
C GY D +C VD CAQ H C Q C N S+ C C
Sbjct: 428 ----------------CHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQC 469
Query: 152 PDGY--RKIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
+G+ + C +D C C++ CVN+ SF CQC G L + ++C ++ C
Sbjct: 470 SEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSC 529
Query: 208 DMGAP-CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFS 266
+G CE C +S +F+C+C +GY L DG +C D C + C++ CVN ++
Sbjct: 530 ALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYT 589
Query: 267 CHCPQGYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSEN 325
C C +G++L + C+ D C+S H C CVN Y C +C E ++ +
Sbjct: 590 CECLEGFRLAEDGKRCRRKDVCKSTHHGCE--HICVNNGNSYIC----KCSEGFVLAEDG 643
Query: 326 RCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQI 363
R C C E P +V I +S+ + F++
Sbjct: 644 R-RCKK----CTEGPIDLV---FVIDGSKSLGEENFEV 673
Score = 123 bits (308), Expect = 4e-28
Identities = 72/249 (28%), Positives = 106/249 (42%), Gaps = 35/249 (14%)
Query: 32 EPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
E Y C GY DP+ + C V+ C C E C+N ++C +IN
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLIN-- 476
Query: 92 HGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151
+D +C VD C + H C S C N+ S+ C C
Sbjct: 477 ------------------------EDLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQC 510
Query: 152 PDGY--RKIGPECVDIDECRY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
P+G+ R G C +D C C+H CV+ SF CQC G+ L + ++C + C
Sbjct: 511 PEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
Query: 208 D-MGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFS 266
+ CE C NS ++ C C +G+ L DG C D C + + C++ CVN +
Sbjct: 571 QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
Query: 267 CHCPQGYQL 275
C C +G+ L
Sbjct: 631 CKCSEGFVL 639
Score = 38.1 bits (87), Expect = 0.016
Identities = 31/127 (24%), Positives = 40/127 (31%), Gaps = 32/127 (25%)
Query: 30 SEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIN 89
S E +C +GY D + CR + C I C E C+N Y C
Sbjct: 542 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTC--------- 590
Query: 90 DLHGEGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ 148
C G+ +D C D C H C C N SY
Sbjct: 591 ------------------ECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYI 630
Query: 149 CTCPDGY 155
C C +G+
Sbjct: 631 CKCSEGF 637
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 155 bits (391), Expect = 9e-38
Identities = 103/321 (32%), Positives = 143/321 (44%), Gaps = 57/321 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C +GY + + C D++EC + C + +C N G +LC+
Sbjct: 901 CYEGYRFSEQQRKCVDIDECTQVQHLCS-QGRCENTEGSFLCI----------------- 942
Query: 99 PVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCT-CPDGYR 156
CP G+ ++ + C+DVDEC + D C N G+++C C GYR
Sbjct: 943 ----------CPAGFMASEEGTNCIDVDECLRP--DVCGEGHCVNTVGAFRCEYCDSGYR 990
Query: 157 KIGP-ECVDIDEC-RYRYC-QHRCVNLPGSFRC-QCEPGFQLGPNNRSCVDVNECDMGAP 212
C DIDEC C +CVN PGS++C C GF+ N C+DV+EC
Sbjct: 991 MTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGW--NGQCLDVDECLEPNV 1048
Query: 213 CEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQ 271
C C N G+++C CH+GY D C DIDEC + +C N G F C C Q
Sbjct: 1049 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 1108
Query: 272 GYQLLATR-LCQDIDECESGAHQCSEAQTCVNFHGGYRCV---------------DTNRC 315
GYQL A + C+DIDEC+ H C+ Q C N G ++CV D N C
Sbjct: 1109 GYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDINEC 1166
Query: 316 VEPYIQVSENRCLCPASNPLC 336
+E C+ A + C
Sbjct: 1167 LEDKSVCQRGDCINTAGSYDC 1187
Score = 142 bits (358), Expect = 6e-34
Identities = 95/302 (31%), Positives = 135/302 (44%), Gaps = 42/302 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNEC----LTIPEACK---GEMKCINHYGGYLCLPRSAAVIND- 90
C GY PD +HCRD++EC L + CK G +C G L + D
Sbjct: 1065 CHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE 1124
Query: 91 -------LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-DSCVDVDECAQALHDCRPSQDCHN 142
HG+ C GY D C D++EC + C+ DC N
Sbjct: 1125 CQHRHLCAHGQCRNTE---GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRG-DCIN 1180
Query: 143 LPGSYQCTCPDGYR-KIGPECVDIDECRYR-YC--QHRCVNLPGSFRCQCEPGFQLGPNN 198
GSY CTCPDG++ C DI+EC + C Q C+N GSF C C+ GF + +
Sbjct: 1181 TAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADG 1240
Query: 199 RSCVDVNECDMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-Q 255
R+C D++EC C+ C N+ G+F C C+QG++ +DG C D++EC S +C +
Sbjct: 1241 RTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE 1300
Query: 256 YRCVNEPGRFSCHCPQGYQ-----------LLATRLCQDIDECESGAHQC----SEAQTC 300
C N G F C C Q +T L D+D+ + +C ++A C
Sbjct: 1301 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1360
Query: 301 VN 302
N
Sbjct: 1361 DN 1362
Score = 119 bits (298), Expect = 6e-27
Identities = 80/225 (35%), Positives = 104/225 (46%), Gaps = 14/225 (6%)
Query: 94 EGPPPPVPPAQHPNPCPPGYEPDDQDSCV-DVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
E PPVP P + V +++EC C C NLP Y C C
Sbjct: 844 EKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGH-CINLPVRYTCICY 902
Query: 153 DGYR--KIGPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
+GYR + +CVDIDEC ++ Q RC N GSF C C GF +C+DV+EC
Sbjct: 903 EGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDEC 962
Query: 208 DMGAPC-EQRCFNSYGTFLCR-CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRF 265
C E C N+ G F C C GY + + G C DIDEC S +CVN PG +
Sbjct: 963 LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSY 1021
Query: 266 SC-HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C C +G++ + C D+DEC + C+ C N G Y C
Sbjct: 1022 QCVPCTEGFRGWNGQ-CLDVDECLE-PNVCANGD-CSNLEGSYMC 1063
Score = 109 bits (272), Expect = 6e-24
Identities = 58/161 (36%), Positives = 83/161 (51%), Gaps = 19/161 (11%)
Query: 177 CVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYEL 234
C+NLP + C C G++ R CVD++EC + C Q RC N+ G+FLC C G+
Sbjct: 890 CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMA 949
Query: 235 HRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSC-HCPQGYQLLATRLCQDIDECESGAHQ 293
+G +C D+DEC + CVN G F C +C GY++ C+DIDEC + +
Sbjct: 950 SEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS-T 1008
Query: 294 CSEAQTCVNFHGGYRCV--------------DTNRCVEPYI 320
C + Q CVN G Y+CV D + C+EP +
Sbjct: 1009 CPDEQ-CVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNV 1048
Score = 97.8 bits (242), Expect = 2e-20
Identities = 100/377 (26%), Positives = 142/377 (37%), Gaps = 92/377 (24%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY HC D+NECL C+ CIN G Y C ++D
Sbjct: 1147 CDQGYRASGLGDHCEDINECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDD---NKTCQ 1202
Query: 99 PVPPAQHPNPCPPGYE------------------PDDQDSCVDVDECAQALHDCRPSQDC 140
+ +HP C P E D +C D+DEC C C
Sbjct: 1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV-CDSHGFC 1261
Query: 141 HNLPGSYQCTCPDGYR--KIGPECVDIDECRYR--YCQHR-CVNLPGSFRCQC-EPGFQL 194
N GS++C C G++ + G CVD++EC C C N+ GSF C C + +
Sbjct: 1262 DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY 1321
Query: 195 GPNNRSC---------VDVNE-----------------CD-MGAP--CEQRCFNSYG--- 222
P C VDV++ CD + AP +Q C + G
Sbjct: 1322 SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGW 1381
Query: 223 -----------------TFLCRCHQGY------ELHRDGFSCSDIDECS-YSSYLCQYR- 257
T +C +G+ G + D DEC + +C+
Sbjct: 1382 GDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGF 1441
Query: 258 CVNEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCV 316
C+N + C+C QG +L C D+DEC+ + C + Q CVN G Y C T+ V
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1499
Query: 317 EPYIQVSENRCLCPASN 333
+ SE RC+ PA +
Sbjct: 1500 ---LDASEKRCIRPAES 1513
Score = 55.8 bits (133), Expect = 7e-08
Identities = 67/264 (25%), Positives = 101/264 (38%), Gaps = 48/264 (18%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G +DP C D++EC P +C + +C+N G Y C V++
Sbjct: 1453 CKQGTYYDPVKLQCFDMDECQD-PSSCI-DGQCVNTEGSYNCFCTHPMVLD--------- 1501
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDV--DECAQALHD----CRPS-------QDCHNLPG 145
C E ++Q DV D C + L D RP +C L G
Sbjct: 1502 -----ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1556
Query: 146 S---YQCT-CP----DGYRKIGPEC-VDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGP 196
QC CP D Y ++ C + + R Y + V+ + + +P F
Sbjct: 1557 EAWGMQCALCPLKDSDDYAQL---CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1613
Query: 197 --NNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYS 250
N+ + EC + CE RC + C C GY L +C D++EC +
Sbjct: 1614 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1673
Query: 251 SYLCQ-YRCVNEPGRFSCHCPQGY 273
LC+ +C+N G + C C GY
Sbjct: 1674 MSLCKNAKCINTDGSYKCLCLPGY 1697
Score = 48.9 bits (115), Expect = 9e-06
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDEC-----RYRYCQ 174
+ +EC L+ C + C + Y C C DGY + CVD++EC R C+
Sbjct: 1621 LQAEECG-ILNGCENGR-CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCK 1678
Query: 175 H-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205
+ +C+N GS++C C PG+ C +N
Sbjct: 1679 NAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 44.3 bits (103), Expect = 2e-04
Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 9/103 (8%)
Query: 245 DECSYSSYLCQYRCVNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQ---CSEAQTC 300
+EC + RCV ++C C GY L A C D++EC+ ++ C A+ C
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-C 1682
Query: 301 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSI 343
+N G Y+C+ C+ Y+ + P + L E+ S +
Sbjct: 1683 INTDGSYKCL----CLPGYVPSDKPNYCTPLNTALNLEKDSDL 1721
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 10/92 (10%)
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSY----QCTCPDGYRKIGPE-CVDIDECRYR- 171
Q+ C + + C Q C P + C GY+++ C DI+EC+ +
Sbjct: 578 QEDCCGTVGTSWGFNKC---QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 634
Query: 172 YCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCV 202
C + C+N GS+RC C+ GF P SCV
Sbjct: 635 VCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666
Score = 43.1 bits (100), Expect = 5e-04
Identities = 21/53 (39%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE 161
C PGY+ + C D++EC L P+ +C N GSY+CTC G+ GP+
Sbjct: 612 CLPGYKRVNNTFCQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGF---GPD 659
Score = 40.4 bits (93), Expect = 0.003
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 187 QCEPGFQLGPNNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGY 232
+C PG++ NN C D+NEC + C C N+ G++ C C G+
Sbjct: 611 ECLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/82 (35%), Positives = 33/82 (40%), Gaps = 19/82 (23%)
Query: 34 DSYT-ECTDGYEWDPDSQHCRDVNECLTI---PEACKGEMKCINHYGGYLCLPRSAAVIN 89
+ YT +C DGY D C DVNEC + CK KCIN G Y CL
Sbjct: 1642 EGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCK-NAKCINTDGSYKCLCL------ 1694
Query: 90 DLHGEGPPPPVPPAQHPNPCPP 111
P P+ PN C P
Sbjct: 1695 --------PGYVPSDKPNYCTP 1708
Score = 34.7 bits (78), Expect = 0.18
Identities = 32/122 (26%), Positives = 47/122 (38%), Gaps = 18/122 (14%)
Query: 225 LCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDI 284
+ C GY+ + F C DI+EC C+N G + C C G+ T
Sbjct: 609 MMECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT-----F 662
Query: 285 DECESGAHQCSEAQ-TCVNFHGGYRCVDTNR-CVEPY-IQVSENRCLC---PASNPLCRE 338
C SE + C YR V + R C+ P + +++ C C A P C +
Sbjct: 663 SSCVPDPPVISEEKGPC------YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEK 716
Query: 339 QP 340
P
Sbjct: 717 CP 718
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 155 bits (391), Expect = 9e-38
Identities = 103/321 (32%), Positives = 143/321 (44%), Gaps = 57/321 (17%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C +GY + + C D++EC + C + +C N G +LC+
Sbjct: 575 CYEGYRFSEQQRKCVDIDECTQVQHLCS-QGRCENTEGSFLCI----------------- 616
Query: 99 PVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCT-CPDGYR 156
CP G+ ++ + C+DVDEC + D C N G+++C C GYR
Sbjct: 617 ----------CPAGFMASEEGTNCIDVDECLRP--DVCGEGHCVNTVGAFRCEYCDSGYR 664
Query: 157 KIGP-ECVDIDEC-RYRYC-QHRCVNLPGSFRC-QCEPGFQLGPNNRSCVDVNECDMGAP 212
C DIDEC C +CVN PGS++C C GF+ N C+DV+EC
Sbjct: 665 MTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGW--NGQCLDVDECLEPNV 722
Query: 213 CEQR-CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQ 271
C C N G+++C CH+GY D C DIDEC + +C N G F C C Q
Sbjct: 723 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 782
Query: 272 GYQLLATR-LCQDIDECESGAHQCSEAQTCVNFHGGYRCV---------------DTNRC 315
GYQL A + C+DIDEC+ H C+ Q C N G ++CV D N C
Sbjct: 783 GYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDINEC 840
Query: 316 VEPYIQVSENRCLCPASNPLC 336
+E C+ A + C
Sbjct: 841 LEDKSVCQRGDCINTAGSYDC 861
Score = 142 bits (358), Expect = 6e-34
Identities = 95/302 (31%), Positives = 135/302 (44%), Gaps = 42/302 (13%)
Query: 39 CTDGYEWDPDSQHCRDVNEC----LTIPEACK---GEMKCINHYGGYLCLPRSAAVIND- 90
C GY PD +HCRD++EC L + CK G +C G L + D
Sbjct: 739 CHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE 798
Query: 91 -------LHGEGPPPPVPPAQHPNPCPPGYEPDDQ-DSCVDVDECAQALHDCRPSQDCHN 142
HG+ C GY D C D++EC + C+ DC N
Sbjct: 799 CQHRHLCAHGQCRNTE---GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRG-DCIN 854
Query: 143 LPGSYQCTCPDGYR-KIGPECVDIDECRYR-YC--QHRCVNLPGSFRCQCEPGFQLGPNN 198
GSY CTCPDG++ C DI+EC + C Q C+N GSF C C+ GF + +
Sbjct: 855 TAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADG 914
Query: 199 RSCVDVNECDMGAPCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLC-Q 255
R+C D++EC C+ C N+ G+F C C+QG++ +DG C D++EC S +C +
Sbjct: 915 RTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE 974
Query: 256 YRCVNEPGRFSCHCPQGYQ-----------LLATRLCQDIDECESGAHQC----SEAQTC 300
C N G F C C Q +T L D+D+ + +C ++A C
Sbjct: 975 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1034
Query: 301 VN 302
N
Sbjct: 1035 DN 1036
Score = 119 bits (298), Expect = 6e-27
Identities = 80/225 (35%), Positives = 104/225 (46%), Gaps = 14/225 (6%)
Query: 94 EGPPPPVPPAQHPNPCPPGYEPDDQDSCV-DVDECAQALHDCRPSQDCHNLPGSYQCTCP 152
E PPVP P + V +++EC C C NLP Y C C
Sbjct: 518 EKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGH-CINLPVRYTCICY 576
Query: 153 DGYR--KIGPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC 207
+GYR + +CVDIDEC ++ Q RC N GSF C C GF +C+DV+EC
Sbjct: 577 EGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDEC 636
Query: 208 DMGAPC-EQRCFNSYGTFLCR-CHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRF 265
C E C N+ G F C C GY + + G C DIDEC S +CVN PG +
Sbjct: 637 LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSY 695
Query: 266 SC-HCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
C C +G++ + C D+DEC + C+ C N G Y C
Sbjct: 696 QCVPCTEGFRGWNGQ-CLDVDECLE-PNVCANGD-CSNLEGSYMC 737
Score = 109 bits (272), Expect = 6e-24
Identities = 58/161 (36%), Positives = 83/161 (51%), Gaps = 19/161 (11%)
Query: 177 CVNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQ-RCFNSYGTFLCRCHQGYEL 234
C+NLP + C C G++ R CVD++EC + C Q RC N+ G+FLC C G+
Sbjct: 564 CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMA 623
Query: 235 HRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSC-HCPQGYQLLATRLCQDIDECESGAHQ 293
+G +C D+DEC + CVN G F C +C GY++ C+DIDEC + +
Sbjct: 624 SEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS-T 682
Query: 294 CSEAQTCVNFHGGYRCV--------------DTNRCVEPYI 320
C + Q CVN G Y+CV D + C+EP +
Sbjct: 683 CPDEQ-CVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNV 722
Score = 97.8 bits (242), Expect = 2e-20
Identities = 100/377 (26%), Positives = 142/377 (37%), Gaps = 92/377 (24%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C GY HC D+NECL C+ CIN G Y C ++D
Sbjct: 821 CDQGYRASGLGDHCEDINECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDD---NKTCQ 876
Query: 99 PVPPAQHPNPCPPGYE------------------PDDQDSCVDVDECAQALHDCRPSQDC 140
+ +HP C P E D +C D+DEC C C
Sbjct: 877 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV-CDSHGFC 935
Query: 141 HNLPGSYQCTCPDGYR--KIGPECVDIDECRYR--YCQHR-CVNLPGSFRCQC-EPGFQL 194
N GS++C C G++ + G CVD++EC C C N+ GSF C C + +
Sbjct: 936 DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY 995
Query: 195 GPNNRSC---------VDVNE-----------------CD-MGAP--CEQRCFNSYG--- 222
P C VDV++ CD + AP +Q C + G
Sbjct: 996 SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGW 1055
Query: 223 -----------------TFLCRCHQGY------ELHRDGFSCSDIDECS-YSSYLCQYR- 257
T +C +G+ G + D DEC + +C+
Sbjct: 1056 GDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGF 1115
Query: 258 CVNEPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCV 316
C+N + C+C QG +L C D+DEC+ + C + Q CVN G Y C T+ V
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1173
Query: 317 EPYIQVSENRCLCPASN 333
+ SE RC+ PA +
Sbjct: 1174 ---LDASEKRCIRPAES 1187
Score = 55.8 bits (133), Expect = 7e-08
Identities = 67/264 (25%), Positives = 101/264 (38%), Gaps = 48/264 (18%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
C G +DP C D++EC P +C + +C+N G Y C V++
Sbjct: 1127 CKQGTYYDPVKLQCFDMDECQD-PSSCI-DGQCVNTEGSYNCFCTHPMVLD--------- 1175
Query: 99 PVPPAQHPNPCPPGYEPDDQDSCVDV--DECAQALHD----CRPS-------QDCHNLPG 145
C E ++Q DV D C + L D RP +C L G
Sbjct: 1176 -----ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1230
Query: 146 S---YQCT-CP----DGYRKIGPEC-VDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGP 196
QC CP D Y ++ C + + R Y + V+ + + +P F
Sbjct: 1231 EAWGMQCALCPLKDSDDYAQL---CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1287
Query: 197 --NNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC---SYS 250
N+ + EC + CE RC + C C GY L +C D++EC +
Sbjct: 1288 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1347
Query: 251 SYLCQ-YRCVNEPGRFSCHCPQGY 273
LC+ +C+N G + C C GY
Sbjct: 1348 MSLCKNAKCINTDGSYKCLCLPGY 1371
Score = 48.9 bits (115), Expect = 9e-06
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CVDIDEC-----RYRYCQ 174
+ +EC L+ C + C + Y C C DGY + CVD++EC R C+
Sbjct: 1295 LQAEECG-ILNGCENGR-CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCK 1352
Query: 175 H-RCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205
+ +C+N GS++C C PG+ C +N
Sbjct: 1353 NAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 44.3 bits (103), Expect = 2e-04
Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 9/103 (8%)
Query: 245 DECSYSSYLCQYRCVNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQ---CSEAQTC 300
+EC + RCV ++C C GY L A C D++EC+ ++ C A+ C
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-C 1356
Query: 301 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSI 343
+N G Y+C+ C+ Y+ + P + L E+ S +
Sbjct: 1357 INTDGSYKCL----CLPGYVPSDKPNYCTPLNTALNLEKDSDL 1395
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 10/92 (10%)
Query: 118 QDSCVDVDECAQALHDCRPSQDCHNLPGSY----QCTCPDGYRKIGPE-CVDIDECRYR- 171
Q+ C + + C Q C P + C GY+++ C DI+EC+ +
Sbjct: 252 QEDCCGTVGTSWGFNKC---QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 308
Query: 172 YCQH-RCVNLPGSFRCQCEPGFQLGPNNRSCV 202
C + C+N GS+RC C+ GF P SCV
Sbjct: 309 VCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340
Score = 43.1 bits (100), Expect = 5e-04
Identities = 21/53 (39%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE 161
C PGY+ + C D++EC L P+ +C N GSY+CTC G+ GP+
Sbjct: 286 CLPGYKRVNNTFCQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGF---GPD 333
Score = 40.4 bits (93), Expect = 0.003
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 187 QCEPGFQLGPNNRSCVDVNECDMGAPCEQ-RCFNSYGTFLCRCHQGY 232
+C PG++ NN C D+NEC + C C N+ G++ C C G+
Sbjct: 285 ECLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/82 (35%), Positives = 33/82 (40%), Gaps = 19/82 (23%)
Query: 34 DSYT-ECTDGYEWDPDSQHCRDVNECLTI---PEACKGEMKCINHYGGYLCLPRSAAVIN 89
+ YT +C DGY D C DVNEC + CK KCIN G Y CL
Sbjct: 1316 EGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCK-NAKCINTDGSYKCLCL------ 1368
Query: 90 DLHGEGPPPPVPPAQHPNPCPP 111
P P+ PN C P
Sbjct: 1369 --------PGYVPSDKPNYCTP 1382
Score = 34.7 bits (78), Expect = 0.18
Identities = 32/122 (26%), Positives = 47/122 (38%), Gaps = 18/122 (14%)
Query: 225 LCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDI 284
+ C GY+ + F C DI+EC C+N G + C C G+ T
Sbjct: 283 MMECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT-----F 336
Query: 285 DECESGAHQCSEAQ-TCVNFHGGYRCVDTNR-CVEPY-IQVSENRCLC---PASNPLCRE 338
C SE + C YR V + R C+ P + +++ C C A P C +
Sbjct: 337 SSCVPDPPVISEEKGPC------YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEK 390
Query: 339 QP 340
P
Sbjct: 391 CP 392
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 147 bits (372), Expect = 1e-35
Identities = 86/244 (35%), Positives = 127/244 (52%), Gaps = 28/244 (11%)
Query: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQ-CTCPDGYRKIGPEC-VDID 166
C + D++ C+ EC+ +L C C +PGS Q C CP G++ GP C D+D
Sbjct: 111 CRGWMQQPDEEGCLSA-ECSASL--CFHGGRC--VPGSAQPCHCPPGFQ--GPRCQYDVD 163
Query: 167 ECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG-APCEQRCFN-SYG 222
ECR CQHRCVN PGS+ C+C+PGF+L ++R+C+ +N C +G C+ C +
Sbjct: 164 ECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTIT 223
Query: 223 TFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLC 281
C+C G++L DG C C+ + C +RC G C C GYQL A + C
Sbjct: 224 RHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC 283
Query: 282 QDIDECESGAHQCSEAQTCVNFHGGYRCV---------DTNRCVEPYIQVSENRCLCPAS 332
+D+DEC +G QC A C+N G ++CV D +C +++ + C A+
Sbjct: 284 EDVDECAAGLAQC--AHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS---CEAN 338
Query: 333 NPLC 336
N C
Sbjct: 339 NGGC 342
Score = 142 bits (358), Expect = 6e-34
Identities = 97/316 (30%), Positives = 131/316 (41%), Gaps = 50/316 (15%)
Query: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
P SY EC G+ DS+ C +N C C+ H+ L + R
Sbjct: 180 PGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQ-------HHCVQLTITR-------- 224
Query: 92 HGEGPPPPVPPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCT 150
H C PG++ +D CV CA C C + G +C
Sbjct: 225 -------------HRCQCRPGFQLQEDGRHCVRRSPCANRNGSC--MHRCQVVRGLARCE 269
Query: 151 CPDGYRKI--GPECVDIDECR--YRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVD--- 203
C GY+ G C D+DEC C H C+N GSF+C C G++LG + R C
Sbjct: 270 CHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEM 329
Query: 204 --VNECDM-GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVN 260
VN C+ C C ++ LC C +GYEL D +C D+D+C+ S CQ C N
Sbjct: 330 EIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA-DSPCCQQVCTN 388
Query: 261 EPGRFSCHCPQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY 319
PG + C C GY+L A C+D+DEC S C C N G ++C C Y
Sbjct: 389 NPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE--HHCTNLAGSFQC----SCEAGY 442
Query: 320 IQVSENRCLCPASNPL 335
+ R P P+
Sbjct: 443 RLHEDRRGCSPLEEPM 458
Score = 139 bits (350), Expect = 5e-33
Identities = 101/300 (33%), Positives = 134/300 (44%), Gaps = 36/300 (12%)
Query: 57 ECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYE-P 115
E T+ C+G M+ + G CL + HG VP + P CPPG++ P
Sbjct: 103 EARTVLRCCRGWMQQPDEEG---CLSAECSASLCFHGGRC---VPGSAQPCHCPPGFQGP 156
Query: 116 DDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR--KIGPECVDIDECRYRY- 172
Q DVDEC C+ C N PGSY C C G+R C+ I+ C
Sbjct: 157 RCQ---YDVDECRTHNGGCQ--HRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNG 211
Query: 173 -CQHRCVNLP-GSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQRCFNSYGTFLCRCH 229
CQH CV L RCQC PGFQL + R CV + C + C RC G C CH
Sbjct: 212 GCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECH 271
Query: 230 QGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLC-----QD 283
GY+L DG +C D+DEC+ C + C+N G F C C GY+L A R C +
Sbjct: 272 VGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEI 331
Query: 284 IDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY-IQVSENRCL----CPASNPLCRE 338
++ CE+ CS C + G C C Y + + C+ C A +P C++
Sbjct: 332 VNSCEANNGGCSHG--CSHTSAGPLCT----CPRGYELDTDQRTCIDVDDC-ADSPCCQQ 384
Score = 53.5 bits (127), Expect = 4e-07
Identities = 79/333 (23%), Positives = 110/333 (33%), Gaps = 94/333 (28%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIN-DLHG---- 93
C GY D C DV+EC + C E C N G + C + ++ D G
Sbjct: 397 CYAGYRLSADGCGCEDVDECASSRGGC--EHHCTNLAGSFQCSCEAGYRLHEDRRGCSPL 454
Query: 94 -------EGPPPPVPPAQH----PNPCPPGYEPDDQDS------------------CVDV 124
+G P V P H + P ++ DD + C+D
Sbjct: 455 EEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDD 514
Query: 125 D---ECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLP 181
+C+ DCR C L G C CP+G+ + C C P
Sbjct: 515 SFGHDCSLTCDDCRNGGTC--LLGLDGCDCPEGWTGL-------------ICNETCP--P 557
Query: 182 GSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSC 241
+F C + SC C G C+ T CRC G G +C
Sbjct: 558 DTFGKNC---------SFSC----SCQNGGTCDSV------TGACRCPPGVS----GTNC 594
Query: 242 SDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCV 301
D Y C+ +C N R CH G L C+ G + TC
Sbjct: 595 EDGCPKGYYGKHCRKKC-NCANRGRCHRLYGACL-----------CDPGLYGRFCHLTCP 642
Query: 302 NFHGGYRCVDTNRCVEPYIQVSENR---CLCPA 331
+ G C + +CV+P+ Q + R C C A
Sbjct: 643 PWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKA 675
Score = 52.4 bits (124), Expect = 8e-07
Identities = 72/276 (26%), Positives = 93/276 (33%), Gaps = 61/276 (22%)
Query: 58 CLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPG-YEPD 116
C I AC+ +C G LCLP ++ + CP G Y P
Sbjct: 782 CQEICPACQHAARCDPETGACLCLPGFVG----------------SRCQDVCPAGWYGPS 825
Query: 117 DQDSCVDVDECAQALHDCRPSQ-DCHNLPG----SYQCTCPDGYRKIGPECVDIDECRYR 171
Q C CA H C P+ C PG S Q C G+ GP+C C
Sbjct: 826 CQTRC----SCANDGH-CHPATGHCSCAPGWTGFSCQRACDTGH--WGPDC--SHPCNCS 876
Query: 172 YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYG------TFL 225
C + G C CE G+ +GP R + G CEQRC +G +
Sbjct: 877 AGHGSCDAISG--LCLCEAGY-VGP--RCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGA 931
Query: 226 CRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG------RFSCHCPQGYQLLATR 279
C C G+ G C + C+ C G SC CP G +
Sbjct: 932 CTCPAGWR----GTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRR---GP 984
Query: 280 LCQDIDECESGAHQCSEAQTCVN------FHGGYRC 309
C + + H CS+A C N HG C
Sbjct: 985 RCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHC 1020
Score = 52.0 bits (123), Expect = 1e-06
Identities = 94/401 (23%), Positives = 119/401 (29%), Gaps = 146/401 (36%)
Query: 39 CTDGYEWDPDSQHCRDVN---------ECLT--IPEACKGEMKCINHYGGYLCLPRSAAV 87
C +G DP S HC ECL + C+ C+N G LC P +
Sbjct: 1048 CQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLN---GGLCDPHTGRC 1104
Query: 88 INDLHGEGPPPPVPPAQHPNPCPPGYEPDD-QDSCVDV---DECAQALHDCRPSQDCHNL 143
+ CP G+ D Q C+ + CAQ C P CH++
Sbjct: 1105 L--------------------CPAGWTGDKCQSPCLRGWFGEACAQRC-SCPPGAACHHV 1143
Query: 144 PGSYQCTCPDGYR-----------KIGPECVDIDEC--------------------RYRY 172
G+ C CP G+ G +C + +C
Sbjct: 1144 TGA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPS 1201
Query: 173 CQHRCVNLPGSF---------------------RCQCEPGF------------QLGPNNR 199
CQ RC PG + C+C GF + GPN
Sbjct: 1202 CQQRCP--PGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPN-- 1257
Query: 200 SCVDVNECDMGAPCEQ---RCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY 256
C V C GA C+ C G RC +G +R G C C
Sbjct: 1258 -CTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGL---- 1312
Query: 257 RCVNEPGRFSC-----------HCPQGYQLLATRL---CQDIDECESGAHQCS-----EA 297
C G SC CP G A L C + CE C
Sbjct: 1313 -CHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYG 1371
Query: 298 QTCVN-----FHGGYRCVDTNRCVE--PYIQVSENRCLCPA 331
Q C + FHG C C P +S RCLCPA
Sbjct: 1372 QACEHPCPPGFHGA-GCQGLCWCQHGAPCDPIS-GRCLCPA 1410
Score = 46.2 bits (108), Expect = 6e-05
Identities = 52/187 (27%), Positives = 65/187 (34%), Gaps = 45/187 (24%)
Query: 109 CPPGYEPDD---QDSCVDVDECAQALHDCRPSQDCHNLPGSY----QCTCPDGYRKIGPE 161
CPPG + SC + C A CR PG Y + CP G+ G +
Sbjct: 1335 CPPGRYGAACHLECSCHNNSTCEPATGTCRCG------PGFYGQACEHPCPPGFHGAGCQ 1388
Query: 162 CVDIDECRYRYCQHRCVNLPGSFRCQCEPGF---------QLGPNNRSCVDVNECDMGAP 212
+ C +CQH P S RC C GF + G C +CD GAP
Sbjct: 1389 GL----C---WCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP 1441
Query: 213 CEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRC------VNEPGRFS 266
C+ T LC C G R G +C+ C C +P
Sbjct: 1442 CDP------VTGLCLCPPG----RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQ 1491
Query: 267 CHCPQGY 273
CHC GY
Sbjct: 1492 CHCVDGY 1498
Score = 42.7 bits (99), Expect = 7e-04
Identities = 63/256 (24%), Positives = 87/256 (33%), Gaps = 84/256 (32%)
Query: 109 CPPG-YEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDE 167
CP G + P + C C+ C ++ G+ CTCP G+R
Sbjct: 904 CPQGHFGPGCEQRC-----------QCQHGAACDHVSGA--CTCPAGWRGT--------- 941
Query: 168 CRYRYCQHRCVNLPGSF-------RCQCEPGFQLGPNNRSCVDVNECDMGAP---CEQRC 217
+C+H C P F C C G N SC+ C G C + C
Sbjct: 942 ----FCEHAC---PAGFFGLDCRSACNCTAGAACDAVNGSCL----CPAGRRGPRCAETC 990
Query: 218 -FNSYG---TFLCRCHQGYE---LHRD--------GFSCSDI-------DECSYSSYLCQ 255
++YG + C C G +H G SC D C +S LCQ
Sbjct: 991 PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSC-LCQ 1049
Query: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315
+P C CP+G+ LA CE +C C++ C
Sbjct: 1050 NGGTCDPVSGHCACPEGWAGLA---------CEK---ECLPRDVRAGCRHSGGCLNGGLC 1097
Query: 316 VEPYIQVSENRCLCPA 331
+P+ RCLCPA
Sbjct: 1098 -DPH----TGRCLCPA 1108
Score = 40.8 bits (94), Expect = 0.002
Identities = 63/252 (25%), Positives = 85/252 (33%), Gaps = 63/252 (25%)
Query: 126 ECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSF- 184
+C A + C C + GS C CP G R GP C + C H C F
Sbjct: 955 DCRSACN-CTAGAACDAVNGS--CLCPAGRR--GPRCAET--CPAHTYGHNCSQACACFN 1007
Query: 185 ---------RCQCEPGFQLGPNNRSCVDVNECDM-GAPCEQRCFNSYGTFL------CRC 228
+C C PG+ +GP SC+ + G C C G C C
Sbjct: 1008 GASCDPVHGQCHCAPGW-MGP---SCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCAC 1063
Query: 229 HQGYELHRDGFSCSDIDECSYSSYLCQYR----CVN----EPGRFSCHCPQGYQLLATRL 280
+G+ G +C EC R C+N +P C CP G+
Sbjct: 1064 PEGWA----GLACEK--ECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGW---TGDK 1114
Query: 281 CQDIDEC------ESGAHQCS--EAQTCVNFHGGYRC---VDTNRCVEP-----YIQVSE 324
CQ C E+ A +CS C + G RC + C + + +
Sbjct: 1115 CQS--PCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCA 1172
Query: 325 NRCLCPASNPLC 336
C CP NP C
Sbjct: 1173 QMCQCPGENPAC 1184
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 145 bits (366), Expect = 7e-35
Identities = 92/293 (31%), Positives = 128/293 (43%), Gaps = 28/293 (9%)
Query: 39 CTDGYEWDPDSQHCRDVNECLTIPEACK-------GEMKCINHYGGYL------CLPRSA 85
C DG+ D +C DV+EC C+ G +C H G +L C+ RS
Sbjct: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSN 161
Query: 86 AVINDLHGEGPPPPV----PPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDC 140
+N ++ + + P C PG++ +Q C C C+ S C
Sbjct: 162 EGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHS--C 217
Query: 141 HNLPGSYQCTCPDGY--RKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNN 198
+ C C Y G C++ C C + RC C GF L P+
Sbjct: 218 EDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDG 277
Query: 199 RSCVDVNECDM-GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR 257
++C D+NEC + C+ C N+ G+F C C +GY+L D +C DIDECS+ C +
Sbjct: 278 KTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFER-TCDHI 336
Query: 258 CVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
C+N PG F C C +GY L T C D+DEC C Q CVN G Y CV
Sbjct: 337 CINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCD--QGCVNTKGSYECV 387
Score = 138 bits (348), Expect = 9e-33
Identities = 80/235 (34%), Positives = 116/235 (49%), Gaps = 34/235 (14%)
Query: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRY----CQHRC 177
VDVDEC++ DC C N P SY+C C GY+ G +C DIDEC Y C H C
Sbjct: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHEC 91
Query: 178 VNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQRCFNSYGTFLCRCHQGYELHR 236
+N+PG++RC C GF L + +C+DV+EC D C+Q C N+ G++ C+CH G+ L
Sbjct: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
Query: 237 DGFSC----SDIDECSYSSYLCQYRCVNEP-GRFSCHCPQGYQLLATRLCQDIDECESGA 291
+ +C ++ C + C + C P G +C C G+ L Q+ +C
Sbjct: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD-----LAQNQKDC---- 202
Query: 292 HQCSEAQTCVNFHGG--YRCVDTNR-----CVEPYIQVSENR-CL--CPASNPLC 336
TC +GG + C DT+ C + Y S+ R C+ C +N C
Sbjct: 203 -----TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC 252
Score = 129 bits (324), Expect = 5e-30
Identities = 101/376 (26%), Positives = 137/376 (36%), Gaps = 128/376 (34%)
Query: 54 DVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGY 113
DV+EC + C + C N Y CL C PGY
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL---------------------------CKPGY 65
Query: 114 EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI--GPECVDIDECRYR 171
+ + + C D+DEC ++ +C N+PG+Y+CTC DG+ G C+D+DEC+
Sbjct: 66 KGEGK-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN 124
Query: 172 Y--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE----------------------- 206
CQ CVN GS+ CQC GF L N +C+ +
Sbjct: 125 NGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGG 184
Query: 207 ---------------------CDMG-APCEQRCFNSYGTFLCRCHQGYELHRD------- 237
C+ G C+ C ++ C CHQ Y LH D
Sbjct: 185 VACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET 244
Query: 238 --------------------------------GFSCSDIDECSYSSYLCQYRCVNEPGRF 265
G +C DI+EC ++ C + C N G F
Sbjct: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSF 304
Query: 266 SCHCPQGYQLLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSE 324
C C +GY+LL R CQDIDEC S C C+N G ++C+ C YI
Sbjct: 305 ECGCRKGYKLLTDERTCQDIDEC-SFERTCD--HICINSPGSFQCL----CHRGYILYGT 357
Query: 325 NRC----LCPASNPLC 336
C C SN C
Sbjct: 358 THCGDVDECSMSNGSC 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.469
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,704,596
Number of Sequences: 37866
Number of extensions: 1374179
Number of successful extensions: 13782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 174
Number of HSP's that attempted gapping in prelim test: 7584
Number of HSP's gapped (non-prelim): 2427
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.