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Search of human proteins with 190341084
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 1575 0.0
gi|190341082 HECT domain containing 2 isoform b [Homo sapiens] 395 e-110
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 346 4e-95
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 346 4e-95
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 346 4e-95
gi|7657152 hect domain and RLD 3 [Homo sapiens] 311 2e-84
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 306 4e-83
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 304 2e-82
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 219 1e-56
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 203 4e-52
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 203 4e-52
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 202 1e-51
gi|110825982 hect domain and RLD 5 [Homo sapiens] 201 2e-51
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 199 8e-51
gi|114520609 neural precursor cell expressed, developmentally do... 196 9e-50
gi|114520607 neural precursor cell expressed, developmentally do... 196 9e-50
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 194 3e-49
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 192 1e-48
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 192 1e-48
gi|222352183 neural precursor cell expressed, developmentally do... 184 3e-46
gi|21361472 neural precursor cell expressed, developmentally dow... 184 3e-46
gi|222352094 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352092 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352090 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352088 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352086 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352084 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352082 neural precursor cell expressed, developmentally do... 184 3e-46
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 183 6e-46
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 181 2e-45
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 1575 bits (4078), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS 60
MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS
Sbjct: 1 MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS 60
Query: 61 SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL 120
SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL
Sbjct: 61 SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL 120
Query: 121 PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI 180
PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI
Sbjct: 121 PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI 180
Query: 181 EDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQ 240
EDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQ
Sbjct: 181 EDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQ 240
Query: 241 FNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKP 300
FNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKP
Sbjct: 241 FNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKP 300
Query: 301 EEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNF 360
EEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNF
Sbjct: 301 EEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNF 360
Query: 361 GNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMK 420
GNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMK
Sbjct: 361 GNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMK 420
Query: 421 VRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF 480
VRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF
Sbjct: 421 VRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF 480
Query: 481 TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSD 540
TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSD
Sbjct: 481 TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSD 540
Query: 541 QNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLK 600
QNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLK
Sbjct: 541 QNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLK 600
Query: 601 PGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEIL 660
PGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEIL
Sbjct: 601 PGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEIL 660
Query: 661 VCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGG 720
VCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGG
Sbjct: 661 VCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGG 720
Query: 721 MADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
MADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE
Sbjct: 721 MADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
>gi|190341082 HECT domain containing 2 isoform b [Homo sapiens]
Length = 207
Score = 395 bits (1016), Expect = e-110
Identities = 200/200 (100%), Positives = 200/200 (100%)
Query: 1 MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS 60
MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS
Sbjct: 1 MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFS 60
Query: 61 SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL 120
SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL
Sbjct: 61 SFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVL 120
Query: 121 PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI 180
PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI
Sbjct: 121 PEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTI 180
Query: 181 EDSGINAKFVNAVYDTLLNT 200
EDSGINAKFVNAVYDTLLNT
Sbjct: 181 EDSGINAKFVNAVYDTLLNT 200
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 346 bits (888), Expect = 4e-95
Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)
Query: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392
PLIP+ +F N L+ + M++ +T+ ++FSF PF+++ K + + D+ +M
Sbjct: 439 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 498
Query: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448
+ R +++ + + Q+ + +L +KVRR H++ D+L L ADLKK+L V
Sbjct: 499 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 555
Query: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508
F GE G+D GG++KE+F L++ +IF+PD GMFTY + + WF+ + +F L+GI+
Sbjct: 556 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 615
Query: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
+GLA+YN+ LD+ FP Y+KL+ T DL P L L +
Sbjct: 616 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 661
Query: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627
LL +EGNVE+D TFQ+ Q + FG Y+LK GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 662 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 721
Query: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685
S+ KQF AF GFH V + L L RPEE+E+L+CGS +LD AL+ +T+YD GY +
Sbjct: 722 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 781
Query: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745
+ I+ FW++V F + ++ L FTTG+DR PVGG+ L I+KN T LP +HTCF
Sbjct: 782 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 841
Query: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
N L LP Y SK+ LK++L+ I+ ++GFG+
Sbjct: 842 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 346 bits (888), Expect = 4e-95
Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)
Query: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392
PLIP+ +F N L+ + M++ +T+ ++FSF PF+++ K + + D+ +M
Sbjct: 419 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 478
Query: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448
+ R +++ + + Q+ + +L +KVRR H++ D+L L ADLKK+L V
Sbjct: 479 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 535
Query: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508
F GE G+D GG++KE+F L++ +IF+PD GMFTY + + WF+ + +F L+GI+
Sbjct: 536 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 595
Query: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
+GLA+YN+ LD+ FP Y+KL+ T DL P L L +
Sbjct: 596 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 641
Query: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627
LL +EGNVE+D TFQ+ Q + FG Y+LK GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 642 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 701
Query: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685
S+ KQF AF GFH V + L L RPEE+E+L+CGS +LD AL+ +T+YD GY +
Sbjct: 702 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 761
Query: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745
+ I+ FW++V F + ++ L FTTG+DR PVGG+ L I+KN T LP +HTCF
Sbjct: 762 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 821
Query: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
N L LP Y SK+ LK++L+ I+ ++GFG+
Sbjct: 822 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 346 bits (888), Expect = 4e-95
Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)
Query: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392
PLIP+ +F N L+ + M++ +T+ ++FSF PF+++ K + + D+ +M
Sbjct: 442 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 501
Query: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448
+ R +++ + + Q+ + +L +KVRR H++ D+L L ADLKK+L V
Sbjct: 502 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 558
Query: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508
F GE G+D GG++KE+F L++ +IF+PD GMFTY + + WF+ + +F L+GI+
Sbjct: 559 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 618
Query: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
+GLA+YN+ LD+ FP Y+KL+ T DL P L L +
Sbjct: 619 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 664
Query: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627
LL +EGNVE+D TFQ+ Q + FG Y+LK GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 665 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 724
Query: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685
S+ KQF AF GFH V + L L RPEE+E+L+CGS +LD AL+ +T+YD GY +
Sbjct: 725 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 784
Query: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745
+ I+ FW++V F + ++ L FTTG+DR PVGG+ L I+KN T LP +HTCF
Sbjct: 785 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 844
Query: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
N L LP Y SK+ LK++L+ I+ ++GFG+
Sbjct: 845 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 311 bits (796), Expect = 2e-84
Identities = 209/614 (34%), Positives = 318/614 (51%), Gaps = 43/614 (7%)
Query: 184 GINAKFVNAVYDTLLNTPQDVQKTVLKGIINS-----LLREWKGPRTKDDLRAYFILLQN 238
GI+ +++ L+N+ + +L+ I+NS + + P + +R Y IL +
Sbjct: 457 GIDLNSTRVLFEKLMNSQHSM---ILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEF 513
Query: 239 PQFNNTSTYV-IYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFP 297
P ++ Y+ + L I L L +W+ ++ K F +LV L + L L
Sbjct: 514 PLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVN-LYKGAVLYLLR 572
Query: 298 AKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDH-IDLMEEYHT 356
+ P+ ++ I +A K+L L N V + Y FY + + +D+ E+Y
Sbjct: 573 GRKTFLIPVLFNNY-ITAALKLLEKLYKVNLKVKH--VEYDTFYIPEISNLVDIQEDYLM 629
Query: 357 W--QNFGNSHRFSF-------CQYPFVISVAAKKIIIQRDSEQQM---INIARQSLVDKV 404
W G R S C YPF+ AK ++Q D+E QM +N A V +
Sbjct: 630 WFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFML 689
Query: 405 SRRQRPDMNILFLNMKVRRTHLVSDSLDELT-RKRADLKKKLKVTFVGEAGLDMGGLTKE 463
+ FL + VRR +LV D+L EL+ DLKK LKV F GE +D GG+TKE
Sbjct: 690 LTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKE 749
Query: 464 WFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRF 523
+FLLL++++ +P YGMFTY++DS+ WFS ++ F L+GI GLA+YNS +D+ F
Sbjct: 750 FFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHF 809
Query: 524 PPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYS 582
P YKKLL N+ G+ +DL ++ P L ELL + G +VEE F
Sbjct: 810 PLALYKKLL---------NVKPGL-----EDLKELSPTEGRSLQELLDYPGEDVEETFCL 855
Query: 583 TFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHS 642
F + +E +G+I+ L PGGD ++V NR+E+V Y +++ S+++ + AF GF
Sbjct: 856 NFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLK 915
Query: 643 VCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDVVLGFPLD 701
VC L L +P E+ ++ G+ + + L+ + Y G Y+ T T+K FW+ FPL+
Sbjct: 916 VCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLE 975
Query: 702 LQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
+KK L F TGSDR+P+ GMA L I + LPVAHTC+N L LP Y SK+ L
Sbjct: 976 KKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSA 1035
Query: 762 KLIIGISNSEGFGL 775
+L + N EGF L
Sbjct: 1036 RLTQALDNYEGFSL 1049
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 306 bits (785), Expect = 4e-83
Identities = 194/561 (34%), Positives = 296/561 (52%), Gaps = 30/561 (5%)
Query: 229 LRAYFILLQNPQFNNTSTYVIYAHLL-RQIATLVEADHHFLVHWFKKLSQKRFKQLVERL 287
LR Y L + P ++++ + A + L +A L +W+ L F ++VE L
Sbjct: 504 LRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVE-L 562
Query: 288 LQFISLRLFPAKPEEFPPITKCSW--WIPSAAKVLALLNTANNLVHPPLIPYTDFY-NST 344
+ + + L PP + + ++ +A KVL +L+ N + +I Y FY +
Sbjct: 563 FKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ-IIQYDKFYIHEV 621
Query: 345 LDHIDLMEEYHTW---QNFGNSHRF--SFCQYPFVISVAAKKIIIQRDSEQQMINIARQS 399
+ ID+ +Y W Q +G + C YPFV AK ++Q D+ QM Q+
Sbjct: 622 QELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQA 681
Query: 400 LVDKVSRRQRPDMNIL--FLNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLD 456
VS P + + L + VRR ++V D+++ L + K D KK LKV FVGE +D
Sbjct: 682 HRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVD 741
Query: 457 MGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNS 516
GG+ KE+FLL++R++ P YGMF Y++DS WFS ++ F L+G++ GLA+YN
Sbjct: 742 AGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNC 801
Query: 517 ITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSH-EGN 575
+D+ FP YKKLL ++DDL ++MP++ + +LL + E +
Sbjct: 802 TIVDLHFPLALYKKLLKK--------------KPSLDDLKELMPDVGRSMQQLLDYPEDD 847
Query: 576 VEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAA 635
+EE F F + E FG + L G +V QNR+E+V Y D++ NKS+ F A
Sbjct: 848 IEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDA 907
Query: 636 FYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDV 694
F+ GFH VC L+L +P E++ +V G+ + D L+++T+Y G Y TIK FW+V
Sbjct: 908 FHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEV 967
Query: 695 VLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYK 754
PL+ +K+ L F TGSDR+P+ GM L I LPV+HTCFN L LP Y
Sbjct: 968 FHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYT 1027
Query: 755 SKKDLKQKLIIGISNSEGFGL 775
K+ L+ KLI I ++EGF L
Sbjct: 1028 EKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 304 bits (779), Expect = 2e-82
Identities = 194/569 (34%), Positives = 296/569 (52%), Gaps = 38/569 (6%)
Query: 229 LRAYFILLQNPQFNNTSTYVIYAHLL-RQIATLVEADHHFLVHWFKKLSQKRFKQLVERL 287
LR Y L + P ++++ + A + L +A L +W+ L F ++VE L
Sbjct: 504 LRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVE-L 562
Query: 288 LQFISLRLFPAKPEEFPPITKCSW--WIPSAAKVLALLNTANNLVHPPLIPYTDFY-NST 344
+ + + L PP + + ++ +A KVL +L+ N + +I Y FY +
Sbjct: 563 FKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ-IIQYDKFYIHEV 621
Query: 345 LDHIDLMEEYHTW---QNFGNSHRF----------SFCQYPFVISVAAKKIIIQRDSEQQ 391
+ ID+ +Y W Q +G + C YPFV AK ++Q D+ Q
Sbjct: 622 QELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQ 681
Query: 392 MINIARQSLVDKVSRRQRPDMNIL--FLNMKVRRTHLVSDSLDELTR-KRADLKKKLKVT 448
M Q+ VS P + + L + VRR ++V D+++ L + K D KK LKV
Sbjct: 682 MQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVI 741
Query: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508
FVGE +D GG+ KE+FLL++R++ P YGMF Y++DS WFS ++ F L+G++
Sbjct: 742 FVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVI 801
Query: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
GLA+YN +D+ FP YKKLL ++DDL ++MP++ + +
Sbjct: 802 CGLAIYNCTIVDLHFPLALYKKLLKK--------------KPSLDDLKELMPDVGRSMQQ 847
Query: 569 LLSH-EGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627
LL + E ++EE F F + E FG + L G +V QNR+E+V Y D++ NK
Sbjct: 848 LLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNK 907
Query: 628 SIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDL 686
S+ F AF+ GFH VC L+L +P E++ +V G+ + D L+++T+Y G Y
Sbjct: 908 SVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHP 967
Query: 687 TIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFN 746
TIK FW+V PL+ +K+ L F TGSDR+P+ GM L I LPV+HTCFN
Sbjct: 968 TIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFN 1027
Query: 747 QLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
L LP Y K+ L+ KLI I ++EGF L
Sbjct: 1028 LLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 219 bits (557), Expect = 1e-56
Identities = 136/373 (36%), Positives = 204/373 (54%), Gaps = 30/373 (8%)
Query: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
+ + V R L DS ++ DL+++L V F GE GLD GG+ +EWF LL ++ +P
Sbjct: 507 IKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP 566
Query: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Y +F Y KD++C S D+ FR +G + +A+++ +D F YK++
Sbjct: 567 MYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRI 626
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEE-DFYSTFQVFQEE 590
L N PVG+ DL I PE + L + E N+EE D F V +E
Sbjct: 627 L---------NKPVGL-----KDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDKEI 670
Query: 591 FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
G IKS++LKP G I VT +N++EY+++ ++ L++ + +Q AF+ GF+ + L
Sbjct: 671 LGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQ 730
Query: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
+E+E+L+CG ++D++ QR Y YA+T I +FW V + + +LL F
Sbjct: 731 YFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFV 790
Query: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
TG+ R+PVGG ADL F I K N LP +HTCFN+L LPPYKS + LK+KL
Sbjct: 791 TGTCRLPVGGFADLMGSNGPQKFCIEK-VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKL 849
Query: 764 IIGISNSEGFGLE 776
+ I +EGFG E
Sbjct: 850 LFAIEETEGFGQE 862
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 203 bits (517), Expect = 4e-52
Identities = 128/373 (34%), Positives = 199/373 (53%), Gaps = 30/373 (8%)
Query: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
+ + V R L DS ++ K DL+++L + GE GLD GG+ +EWF LL ++ +P
Sbjct: 76 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP 135
Query: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Y +F Y K+++C SS D+ + FR +G + +A+Y+ +D F YK++
Sbjct: 136 MYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 195
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L+ T+ DL I PE + + + E N+EE + + E
Sbjct: 196 LNK--------------RPTLKDLESIDPEFYNSIVWI--KENNLEECGLELYFIQDMEI 239
Query: 592 -GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
G + ++ LK GG+ I VT +N++EY+ L TD+ + + +Q AF GF+ V L
Sbjct: 240 LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLR 299
Query: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
+E+E+++CG ++DM Q+ST Y Y K I++FW VV + + +LL F
Sbjct: 300 YFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 359
Query: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
TG+ R+PVGG A+L F I K T LP +HTCFN+L LPPYKS + L++KL
Sbjct: 360 TGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKL 418
Query: 764 IIGISNSEGFGLE 776
+ I +EGFG E
Sbjct: 419 LYAIEETEGFGQE 431
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 203 bits (517), Expect = 4e-52
Identities = 128/373 (34%), Positives = 199/373 (53%), Gaps = 30/373 (8%)
Query: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
+ + V R L DS ++ K DL+++L + GE GLD GG+ +EWF LL ++ +P
Sbjct: 515 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP 574
Query: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Y +F Y K+++C SS D+ + FR +G + +A+Y+ +D F YK++
Sbjct: 575 MYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 634
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L+ T+ DL I PE + + + E N+EE + + E
Sbjct: 635 LNK--------------RPTLKDLESIDPEFYNSIVWI--KENNLEECGLELYFIQDMEI 678
Query: 592 -GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
G + ++ LK GG+ I VT +N++EY+ L TD+ + + +Q AF GF+ V L
Sbjct: 679 LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLR 738
Query: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
+E+E+++CG ++DM Q+ST Y Y K I++FW VV + + +LL F
Sbjct: 739 YFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
Query: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
TG+ R+PVGG A+L F I K T LP +HTCFN+L LPPYKS + L++KL
Sbjct: 799 TGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKL 857
Query: 764 IIGISNSEGFGLE 776
+ I +EGFG E
Sbjct: 858 LYAIEETEGFGQE 870
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 202 bits (514), Expect = 1e-51
Identities = 129/375 (34%), Positives = 197/375 (52%), Gaps = 42/375 (11%)
Query: 421 VRRTHLVSDSLDELTRKRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGM 479
VRR H+ DS EL RK + +K +L + F GE G D GGL +EW++++ R++F+P Y +
Sbjct: 4021 VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL 4080
Query: 480 F----------TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYK 529
F T + SHC+ ++ S F+ VG ++ AVY++ L+ F YK
Sbjct: 4081 FRTSPGDRVTYTINPSSHCN------PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYK 4134
Query: 530 KLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYS-TFQVFQ 588
+L + +D +D GL LL E +V Y TF
Sbjct: 4135 HILGKSVRYTDMES---------EDY-----HFYQGLVYLL--ENDVSTLGYDLTFSTEV 4178
Query: 589 EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648
+EFG+ + +LKP G I VT +N+KEYV L + +I KQ AAF GF+ +
Sbjct: 4179 QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRL 4238
Query: 649 LMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708
+ + +E+E+L+ G P +D+ L+ +T+Y Y + I++FW + F + K L
Sbjct: 4239 ISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQ 4298
Query: 709 FTTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
F TG+ +VP+ G A L F+I +++ ST+ LP AHTCFNQL LP Y+S + L+
Sbjct: 4299 FVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRH 4358
Query: 762 KLIIGISN-SEGFGL 775
L++ I SEGFGL
Sbjct: 4359 MLLLAIQECSEGFGL 4373
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 201 bits (511), Expect = 2e-51
Identities = 122/414 (29%), Positives = 214/414 (51%), Gaps = 25/414 (6%)
Query: 368 FCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILF---LNMKVRRT 424
F +PF+ + +K ++ D+ ++ + ++ + + + + ++ VRR
Sbjct: 629 FSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRN 688
Query: 425 HLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYH 483
HL+ D L++L++ + DL+K+L V+F GE G D+GG+ KE+F L ++ P+YGMF Y
Sbjct: 689 HLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYP 748
Query: 484 KDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNI 543
+ + C WF + G+L GL+++N ++ FP +KKLL +PS
Sbjct: 749 EGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQ--MPS---- 802
Query: 544 PVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYSTFQVFQEEFGIIKSYNLKPG 602
++DL ++ P+L L LL EG N EE FY F V + NL P
Sbjct: 803 --------LEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDR----NDTNLIPN 850
Query: 603 GDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVC 662
G I+V N+++YV Y +++ N S+ + F GF+ +C + + L PEE++ ++
Sbjct: 851 GSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIV 910
Query: 663 GSPDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGM 721
G+ D D +++ +Y+ GY + TI FW L+ +KK L F TG+DR+ + +
Sbjct: 911 GNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDL 970
Query: 722 ADLNFKISKNETSTNCLPV-AHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFG 774
++ E+ P+ A TCF+ L LP Y + + +++ L I+N+ GFG
Sbjct: 971 NNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 199 bits (506), Expect = 8e-51
Identities = 129/375 (34%), Positives = 200/375 (53%), Gaps = 34/375 (9%)
Query: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
+ + V R L DS ++ K DL+++L V F GE GLD GGL +EWF LL ++ +P
Sbjct: 567 VKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNP 626
Query: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Y +F Y K+++C S+ D+ S F +G + +A+++ +D F YK++
Sbjct: 627 MYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRM 686
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEE---DFYSTFQVFQ 588
LS + T+ DL I E + L + + N+EE + Y F V
Sbjct: 687 LSKKL--------------TIKDLESIDTEFYNSL--IWIRDNNIEECGLEMY--FSVDM 728
Query: 589 EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648
E G + S++LK GG I VT +N+ EY+ L T++ ++ + +Q AF GF+ V
Sbjct: 729 EILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQW 788
Query: 649 LMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708
L +E+E+++CG ++D+ QR+T Y Y + I +FW V +++ +LL
Sbjct: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 848
Query: 709 FTTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
F TG+ R+P+GG A+L F I K T LP +HTCFN+L LPPYKS + LK+
Sbjct: 849 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKE 907
Query: 762 KLIIGISNSEGFGLE 776
KL+ I +EGFG E
Sbjct: 908 KLLFAIEETEGFGQE 922
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 196 bits (497), Expect = 9e-50
Identities = 130/370 (35%), Positives = 202/370 (54%), Gaps = 33/370 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+RR ++ DS + KRAD LK +L + F GE GLD GG+ +EWF L+ +++F+P
Sbjct: 545 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 604
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F+ +G + G+AVY+ LD F YK +
Sbjct: 605 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 664
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L PI T+ D+ + E + L +L ++ + F + +E F
Sbjct: 665 LHKPI--------------TLHDMESVDSEYYNSLRWILENDPT---ELDLRFIIDEELF 707
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G + LK GG +I VTN+N+KEY+ L + I KQ AAF GF + + + +
Sbjct: 708 GQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKI 767
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ + T+Y +GY+ I++FW VL + + +LL F
Sbjct: 768 FDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFV 827
Query: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
TG+ RVP+ G A+L +F + + T LP AHTCFN+L LPPY+S ++L KL
Sbjct: 828 TGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKL 886
Query: 764 IIGISNSEGF 773
+ I N++GF
Sbjct: 887 QMAIENTQGF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 196 bits (497), Expect = 9e-50
Identities = 130/370 (35%), Positives = 202/370 (54%), Gaps = 33/370 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+RR ++ DS + KRAD LK +L + F GE GLD GG+ +EWF L+ +++F+P
Sbjct: 892 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 951
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F+ +G + G+AVY+ LD F YK +
Sbjct: 952 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 1011
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L PI T+ D+ + E + L +L ++ + F + +E F
Sbjct: 1012 LHKPI--------------TLHDMESVDSEYYNSLRWILENDPT---ELDLRFIIDEELF 1054
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G + LK GG +I VTN+N+KEY+ L + I KQ AAF GF + + + +
Sbjct: 1055 GQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKI 1114
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ + T+Y +GY+ I++FW VL + + +LL F
Sbjct: 1115 FDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFV 1174
Query: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
TG+ RVP+ G A+L +F + + T LP AHTCFN+L LPPY+S ++L KL
Sbjct: 1175 TGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKL 1233
Query: 764 IIGISNSEGF 773
+ I N++GF
Sbjct: 1234 QMAIENTQGF 1243
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 194 bits (493), Expect = 3e-49
Identities = 127/398 (31%), Positives = 204/398 (51%), Gaps = 35/398 (8%)
Query: 391 QMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRA-DLKKKLKVTF 449
Q + I RQ L +Q+P ++V R + +S ++ + R DL K+L + F
Sbjct: 374 QKLKILRQEL-----SQQQPQAG--HCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKF 426
Query: 450 VGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDS----HCHWFSSFKCDNYSEFRLV 505
GE GLD GG+ +EW LL ++ +P YG+F Y +D + S+ ++ S F V
Sbjct: 427 RGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFV 486
Query: 506 GILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHG 565
G +MG+AV++ +D F YK+LL ++T+DD+ + P+L +
Sbjct: 487 GRIMGMAVFHGHYIDGGFTLPFYKQLLGK--------------SITLDDMELVDPDLHNS 532
Query: 566 LSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLL 625
L +L E ++ TF V +G I + LKP G I V +N+KEYV+LY ++
Sbjct: 533 LVWIL--ENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRF 590
Query: 626 NKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTD 685
+ I QF A GF+ V + L +E+E+++CG +D++ + +T+
Sbjct: 591 LRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDS 650
Query: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLN-------FKISKNETSTNCL 738
+K+FW V F + + +LL F TGS RVP+ G L F I + + TN L
Sbjct: 651 NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNL 710
Query: 739 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
P AHTCFN++ +PPY+S + L +KL+ I + GF +E
Sbjct: 711 PKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 192 bits (488), Expect = 1e-48
Identities = 122/373 (32%), Positives = 192/373 (51%), Gaps = 31/373 (8%)
Query: 419 MKVRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDY 477
++V R + +S ++ + R DLKK+L V F GE GLD GG+ +EW LL ++ +P Y
Sbjct: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
Query: 478 GMFTYHKDS----HCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLS 533
G+F Y D+ + SS D+ S F VG +MGLAV++ ++ F YK+LL
Sbjct: 461 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 520
Query: 534 PPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGI 593
PI + DL + PEL L +L E ++ TF V FG
Sbjct: 521 KPI--------------QLSDLESVDPELHKSLVWIL--ENDITPVLDHTFCVEHNAFGR 564
Query: 594 IKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLR 653
I + LKP G + VT +N+KEYV+LY ++ + I QF A GF+ + + L
Sbjct: 565 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD 624
Query: 654 PEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGS 713
+E+E+++ G +D++ + +T+ +++FW V F + + +LL F TGS
Sbjct: 625 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 684
Query: 714 DRVPVGGMADLN----------FKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
RVP+ G L F I + +T+ LP AHTCFN++ +PPY+S + L +KL
Sbjct: 685 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL 744
Query: 764 IIGISNSEGFGLE 776
+ + + GF +E
Sbjct: 745 LTAVEETCGFAVE 757
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 192 bits (488), Expect = 1e-48
Identities = 122/373 (32%), Positives = 192/373 (51%), Gaps = 31/373 (8%)
Query: 419 MKVRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDY 477
++V R + +S ++ + R DLKK+L V F GE GLD GG+ +EW LL ++ +P Y
Sbjct: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
Query: 478 GMFTYHKDS----HCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLS 533
G+F Y D+ + SS D+ S F VG +MGLAV++ ++ F YK+LL
Sbjct: 435 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 494
Query: 534 PPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGI 593
PI + DL + PEL L +L E ++ TF V FG
Sbjct: 495 KPI--------------QLSDLESVDPELHKSLVWIL--ENDITPVLDHTFCVEHNAFGR 538
Query: 594 IKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLR 653
I + LKP G + VT +N+KEYV+LY ++ + I QF A GF+ + + L
Sbjct: 539 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD 598
Query: 654 PEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGS 713
+E+E+++ G +D++ + +T+ +++FW V F + + +LL F TGS
Sbjct: 599 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 658
Query: 714 DRVPVGGMADLN----------FKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
RVP+ G L F I + +T+ LP AHTCFN++ +PPY+S + L +KL
Sbjct: 659 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL 718
Query: 764 IIGISNSEGFGLE 776
+ + + GF +E
Sbjct: 719 LTAVEETCGFAVE 731
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 842 MAVENAQGF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 600 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 659
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 660 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 719
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 720 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 762
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 763 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 822
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 823 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 882
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 883 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 942
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 943 MAVENAQGF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 599 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 641
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 642 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 702 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 761
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 762 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 822 MAVENAQGF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 599 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 641
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 642 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 702 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 761
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 762 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 822 MAVENAQGF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 592 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 651
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 652 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 711
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 712 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 754
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 755 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 814
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 815 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 874
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 875 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 934
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 935 MAVENAQGF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 612 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 671
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 672 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 731
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 732 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 774
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 775 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 834
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 835 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 894
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 895 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 954
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 955 MAVENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 620 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 679
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 680 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 739
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 740 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 782
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 783 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 842
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 843 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 902
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 903 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 962
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 963 MAVENAQGF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 842 MAVENAQGF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661
Query: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781
Query: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 765 IGISNSEGF 773
+ + N++GF
Sbjct: 842 MAVENAQGF 850
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 183 bits (464), Expect = 6e-46
Identities = 123/374 (32%), Positives = 197/374 (52%), Gaps = 31/374 (8%)
Query: 417 LNMKVRRTHLVSDSLDELTR-KRADLKK-KLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH 474
L + +RR HL+ D+ +++ R DL++ KL VTFVGE GLD G ++E+F L+ R++F+
Sbjct: 1216 LKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFN 1275
Query: 475 PDYGMFTYH-KDSHCHWFSSFKC--DNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKK 530
P YG+F Y D++ S DN+ E FR G ++GLA+ + LD F YK
Sbjct: 1276 PYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKA 1335
Query: 531 LLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEE 590
LL +C+++ DL + E L + + ++ + TF V +E
Sbjct: 1336 LLRI------------LCDLS--DLEYLDEEFHQSLQWM--KDNDIHDILDLTFTVNEEV 1379
Query: 591 FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
FG I LKPGG I VT +N+KEY++ + + + + +Q + GF+ V + +
Sbjct: 1380 FGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVS 1439
Query: 651 LLRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHF 709
+ E+E+++ G+ ++D+ + +T+Y GY + I++FW V F + + +LL F
Sbjct: 1440 VFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQF 1499
Query: 710 TTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQK 762
TG+ +P G A L F + K T LP AHTCFN+L LPPY S L +K
Sbjct: 1500 VTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEK 1558
Query: 763 LIIGISNSEGFGLE 776
L+ + + FGLE
Sbjct: 1559 LLTAVEETSTFGLE 1572
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 181 bits (459), Expect = 2e-45
Identities = 119/359 (33%), Positives = 184/359 (51%), Gaps = 28/359 (7%)
Query: 421 VRRTHLVSDSLDELTRKR-ADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGM 479
V R + S + +++ A LK+ + V F GE G+ G + +EWF +L +I +PDY +
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 480 FTYHKDSHCHWFSS---FKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPI 536
FT D +S D+ + FR G ++GLA+ + ++I F YK +L P
Sbjct: 616 FTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP- 674
Query: 537 IPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKS 596
V D+ I PE A L +L ++ + + TF V + FG ++
Sbjct: 675 -------------VNYQDVASIDPEYAKNLQWILDNDIS-DLGLELTFSVETDVFGAMEE 720
Query: 597 YNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEE 656
LKPGG I VT N+ EYVQL T+ + ++I Q AF GFH + + L E
Sbjct: 721 VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE 780
Query: 657 VEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDR 715
+E+L+ G P++D+ ++T+Y GY + D I++FW+VV + + LL F TGS R
Sbjct: 781 LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR 840
Query: 716 VPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGI 767
VP GG A++ NF I+ + N LP + TC N L LP Y SK+ LK +L++ +
Sbjct: 841 VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,300,725
Number of Sequences: 37866
Number of extensions: 1403099
Number of successful extensions: 4239
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4023
Number of HSP's gapped (non-prelim): 80
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.