Search of human proteins with 189491778

Search of human proteins with 189491778

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
         (614 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]                 1232   0.0  
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]                 1173   0.0  
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]                 1098   0.0  
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]                  1084   0.0  
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    57   4e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    57   4e-08
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    57   4e-08
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    55   2e-07
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...    55   2e-07
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ...    54   4e-07
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...    53   7e-07
gi|21735415 centromere protein B [Homo sapiens]                        53   7e-07
gi|55749544 SH3 multiple domains 1 [Homo sapiens]                      52   2e-06
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    52   2e-06
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    52   2e-06
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    52   2e-06
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    52   2e-06
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    52   2e-06
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap...    51   4e-06
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        51   4e-06
gi|20149528 proline-serine-threonine phosphatase interacting pro...    50   5e-06
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     50   6e-06
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     50   6e-06
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...    49   1e-05
gi|130977759 tec protein tyrosine kinase [Homo sapiens]                49   1e-05
gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]      49   2e-05
gi|17975763 myelin transcription factor 1 [Homo sapiens]               48   2e-05
gi|109689723 abl interactor 2 [Homo sapiens]                           48   3e-05
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              48   3e-05
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]      48   3e-05

>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
          Length = 614

 Score = 1232 bits (3187), Expect = 0.0
 Identities = 614/614 (100%), Positives = 614/614 (100%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESE 60
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESE
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESE 60

Query: 61  SEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVI 120
           SEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVI
Sbjct: 61  SEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVI 120

Query: 121 EKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQ 180
           EKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQ
Sbjct: 121 EKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQ 180

Query: 181 RTDPHWSAVQKAISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPS 240
           RTDPHWSAVQKAISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPS
Sbjct: 181 RTDPHWSAVQKAISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPS 240

Query: 241 QLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVL 300
           QLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVL
Sbjct: 241 QLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVL 300

Query: 301 SNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRN 360
           SNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRN
Sbjct: 301 SNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRN 360

Query: 361 STGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFY 420
           STGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFY
Sbjct: 361 STGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFY 420

Query: 421 QIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMS 480
           QIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMS
Sbjct: 421 QIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMS 480

Query: 481 LQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHD 540
           LQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHD
Sbjct: 481 LQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHD 540

Query: 541 CVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSE 600
           CVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSE
Sbjct: 541 CVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSE 600

Query: 601 QTYDFLGEMRKNAV 614
           QTYDFLGEMRKNAV
Sbjct: 601 QTYDFLGEMRKNAV 614


>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
          Length = 677

 Score = 1173 bits (3035), Expect = 0.0
 Identities = 605/678 (89%), Positives = 611/678 (90%), Gaps = 65/678 (9%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQL-------------------KEALEPNK 41
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQL                   K+A++ NK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 42  --------------------------------------------RQHIYQRVGAPTEEEE 57
                                                       R++I + VGAPTEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE-VGAPTEEEE 119

Query: 58  ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 117
           ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL
Sbjct: 120 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 179

Query: 118 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 177
           LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE
Sbjct: 180 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239

Query: 178 VKQRTDPHWSAVQKAISE-INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 236
           VKQRTDPHWSAVQKAISE INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE
Sbjct: 240 VKQRTDPHWSAVQKAISEQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 299

Query: 237 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 296
           LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
Sbjct: 300 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 359

Query: 297 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 356
           NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS
Sbjct: 360 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 419

Query: 357 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 416
           YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG
Sbjct: 420 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 479

Query: 417 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 476
           SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
Sbjct: 480 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 539

Query: 477 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 536
           DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL
Sbjct: 540 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 599

Query: 537 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 596
           VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF
Sbjct: 600 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 659

Query: 597 DLSEQTYDFLGEMRKNAV 614
           DLSEQTYDFLGEMRKNAV
Sbjct: 660 DLSEQTYDFLGEMRKNAV 677


>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
          Length = 732

 Score = 1098 bits (2841), Expect = 0.0
 Identities = 584/737 (79%), Positives = 598/737 (81%), Gaps = 128/737 (17%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQL-------------------KEALEPNK 41
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQL                   K+A++ NK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 42  --------------------------------------------RQHIYQRVGAPTEEEE 57
                                                       R++I + VGAPTEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE-VGAPTEEEE 119

Query: 58  ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 117
           ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL
Sbjct: 120 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 179

Query: 118 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED------------ 165
           LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED            
Sbjct: 180 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239

Query: 166 ----------------------------------------VEAVDETADGAEVKQRTDPH 185
                                                   +E V++T +G+E   R    
Sbjct: 240 VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDT-NGSETGFRA--- 295

Query: 186 WSA--------VQKAISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 237
           W+         V K + +INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL
Sbjct: 296 WNVQSRGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 355

Query: 238 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 297
           MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN
Sbjct: 356 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 415

Query: 298 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 357
           KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY
Sbjct: 416 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 475

Query: 358 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 417
           IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS
Sbjct: 476 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 535

Query: 418 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 477
           VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD
Sbjct: 536 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 595

Query: 478 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 537
           RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV
Sbjct: 596 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 655

Query: 538 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 597
           YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD
Sbjct: 656 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 715

Query: 598 LSEQTYDFLGEMRKNAV 614
           LSEQTYDFLGEMRKNAV
Sbjct: 716 LSEQTYDFLGEMRKNAV 732


>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
          Length = 733

 Score = 1084 bits (2803), Expect = 0.0
 Identities = 578/738 (78%), Positives = 595/738 (80%), Gaps = 129/738 (17%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQL-------------------KEALEPNK 41
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQL                   K+A++ NK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 42  --------------------------------------------RQHIYQRVGAPTEEEE 57
                                                       R++I + VGAPTEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE-VGAPTEEEE 119

Query: 58  ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 117
           ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL
Sbjct: 120 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 179

Query: 118 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE--------------EGSE 163
           LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE              +G+E
Sbjct: 180 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239

Query: 164 --------------------------------------EDVEAVDETADGAEVKQRTDPH 185
                                                   +E V++T +G+E   R    
Sbjct: 240 VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDT-NGSETGFRA--- 295

Query: 186 WSAVQKA---------ISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 236
           W+   +          + +INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE
Sbjct: 296 WNVQSRGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 355

Query: 237 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 296
           LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
Sbjct: 356 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 415

Query: 297 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 356
           NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS
Sbjct: 416 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 475

Query: 357 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 416
           YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG
Sbjct: 476 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 535

Query: 417 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 476
           SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
Sbjct: 536 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 595

Query: 477 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 536
           DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL
Sbjct: 596 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 655

Query: 537 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 596
           VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF
Sbjct: 656 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 715

Query: 597 DLSEQTYDFLGEMRKNAV 614
           DLSEQTYDFLGEMRKNAV
Sbjct: 716 DLSEQTYDFLGEMRKNAV 733


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 69   GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 124
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 929  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 986

Query: 125  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 173
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 987  DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1035



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/169 (27%), Positives = 78/169 (46%), Gaps = 26/169 (15%)

Query: 2   LARRQRDPLQALRRRNQEL--------------KQQVDSLLSESQLKEALEPNKRQHIYQ 47
           L + +RD L+ + R+  EL              KQ  ++L  E+  KE  E  KR    +
Sbjct: 637 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 696

Query: 48  RVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVG 107
                T+E+ + E   +E+   +++D  + EE+K E      S    Y A+  F A+   
Sbjct: 697 -----TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA----SVLVNYRALYPFEARNHD 747

Query: 108 DLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 153
           +++F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 748 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 94   EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 153
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1104 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1162

Query: 154  GQE 156
             Q+
Sbjct: 1163 SQQ 1165



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 97  AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 156
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 878 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 935

Query: 157 SSE 159
             E
Sbjct: 936 EPE 938


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 69   GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 124
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 956  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013

Query: 125  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 173
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/169 (27%), Positives = 78/169 (46%), Gaps = 26/169 (15%)

Query: 2   LARRQRDPLQALRRRNQEL--------------KQQVDSLLSESQLKEALEPNKRQHIYQ 47
           L + +RD L+ + R+  EL              KQ  ++L  E+  KE  E  KR    +
Sbjct: 664 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 723

Query: 48  RVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVG 107
                T+E+ + E   +E+   +++D  + EE+K E      S    Y A+  F A+   
Sbjct: 724 -----TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA----SVLVNYRALYPFEARNHD 774

Query: 108 DLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 153
           +++F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 775 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 94   EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 153
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189

Query: 154  GQE 156
             Q+
Sbjct: 1190 SQQ 1192



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 97  AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 156
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962

Query: 157 SSE 159
             E
Sbjct: 963 EPE 965


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 69   GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 124
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 956  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013

Query: 125  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 173
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/169 (27%), Positives = 78/169 (46%), Gaps = 26/169 (15%)

Query: 2   LARRQRDPLQALRRRNQEL--------------KQQVDSLLSESQLKEALEPNKRQHIYQ 47
           L + +RD L+ + R+  EL              KQ  ++L  E+  KE  E  KR    +
Sbjct: 664 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 723

Query: 48  RVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVG 107
                T+E+ + E   +E+   +++D  + EE+K E      S    Y A+  F A+   
Sbjct: 724 -----TQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA----SVLVNYRALYPFEARNHD 774

Query: 108 DLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 153
           +++F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 775 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 94   EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 153
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189

Query: 154  GQE 156
             Q+
Sbjct: 1190 SQQ 1192



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 97  AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 156
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962

Query: 157 SSE 159
             E
Sbjct: 963 EPE 965


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/165 (29%), Positives = 73/165 (44%), Gaps = 32/165 (19%)

Query: 14  RRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEED 73
           + RNQE+++  +    E + +E                  EEEEE E E  E+  GEE +
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEG---------------DREEEEEKEGEGKEEGEGEEVE 765

Query: 74  AEEEEEE---KEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIA 130
            E E+EE   K+E  + K   GEE    G+   ++    T  +GE     EK+  G    
Sbjct: 766 GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEE----TEGRGE-----EKEEGG---- 812

Query: 131 KDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADG 175
            + +G E    +   E   EE EG+E   EG EE+ E  +E  +G
Sbjct: 813 -EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 41/124 (33%), Positives = 57/124 (45%), Gaps = 13/124 (10%)

Query: 50   GAPTEEEEESESEDSEDSG--------GEEEDAEEEEEEKEENESHKW-STGEEYIAVGD 100
            G   EEE E E ED E  G        GEEE+ E E EE+ E E  +    GEE    G+
Sbjct: 930  GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGE 989

Query: 101  FTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEE 160
               ++  +   ++GE     E++ +G    ++    EG V     E   EEEEG+E  EE
Sbjct: 990  GEEEEGEEEGEEEGE----GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045

Query: 161  GSEE 164
              +E
Sbjct: 1046 REKE 1049



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 15/130 (11%)

Query: 54   EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 113
            EEE E E E+ E  G EEE   E EEE+ E E  +   GEE    G+   ++ G++   +
Sbjct: 967  EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE-GEGEGEEEEEGEV---E 1022

Query: 114  GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 173
            GE+     +  +G    ++ +G E    R       +E EG+E+     EE+ E      
Sbjct: 1023 GEV-----EGEEGEGEGEEEEGEEEGEER------EKEGEGEENRRNREEEEEEEGKYQE 1071

Query: 174  DGAEVKQRTD 183
             G E  +R D
Sbjct: 1072 TGEEENERQD 1081



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 12/131 (9%)

Query: 50  GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ-QVGD 108
           G   EE +    E+ E+  GEEE+ E EEEE E  E      GEE    G+   + + G+
Sbjct: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE 875

Query: 109 LTFKKGEILLVIEKKPDGWWIAKDAKG---NEGLVPRTYLEPYSEEEEGQ-ESSEEGSEE 164
              ++ E     E++ +G    ++ +G    EG       E   EEEEG+ +  EEG E 
Sbjct: 876 GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-------EGEGEEEEGEGKGEEEGEEG 928

Query: 165 DVEAVDETADG 175
           + E  +E  +G
Sbjct: 929 EGEGEEEEGEG 939



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 43/140 (30%), Positives = 60/140 (42%), Gaps = 31/140 (22%)

Query: 54   EEEEESESEDSEDSG-----GEEEDAEEEEEEKE----------ENESHKWSTGEEYIAV 98
            EEE E E E+ E  G     GEE + E EEEE E          E E  +W  GEE    
Sbjct: 905  EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE-GEEEEGE 963

Query: 99   GDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESS 158
            G+   +  G+    +GE      ++ +G    ++ +G          E   EE EG+E  
Sbjct: 964  GEGEEEGEGEGEEGEGE-----GEEEEGEGEGEEEEGE---------EEGEEEGEGEEEG 1009

Query: 159  E-EGSEEDVEAVDETADGAE 177
            E EG EE+   V+   +G E
Sbjct: 1010 EGEGEEEEEGEVEGEVEGEE 1029



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 41/159 (25%), Positives = 64/159 (40%), Gaps = 11/159 (6%)

Query: 30  ESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKW 89
           E +L E  E  KR    Q      +  ++  +++ E+ G EE    EEEE   E E  K 
Sbjct: 693 EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752

Query: 90  STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKK-------PDGWWIAKDAKGNE----G 138
             G+E     +   ++  +   +K E     E+K        +G     + +G E    G
Sbjct: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812

Query: 139 LVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 177
            V    +E    E E +E   EG EE+ E  +E  +G E
Sbjct: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/126 (31%), Positives = 54/126 (42%), Gaps = 27/126 (21%)

Query: 55  EEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKG 114
           EEEE E E  E+  GE E+ EE E + EE        GEE    G+      G+    +G
Sbjct: 896 EEEEGEGEGEEEGEGEGEE-EEGEGKGEEEGEEGEGEGEEEEGEGE------GEDGEGEG 948

Query: 115 EILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE---EGQESSEEGSEEDVEAVDE 171
           E       + +G W  ++ +G          E   EEE   EG+E   EG EE+ E   E
Sbjct: 949 E-------EEEGEWEGEEEEG----------EGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991

Query: 172 TADGAE 177
             +G E
Sbjct: 992 EEEGEE 997



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 36/128 (28%), Positives = 52/128 (40%), Gaps = 26/128 (20%)

Query: 50  GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDL 109
           G   EE  E E  + E+  GE E+ EEE E +EE    +   GE     G+   ++ G+ 
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE- 863

Query: 110 TFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAV 169
              +GE                + +G EG       E   EEEEG+   EE  E + E  
Sbjct: 864 ---EGE---------------GEEEGEEG-------EGEGEEEEGEGEGEEEGEGEGEEE 898

Query: 170 DETADGAE 177
           +   +G E
Sbjct: 899 EGEGEGEE 906



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 42/155 (27%), Positives = 77/155 (49%), Gaps = 14/155 (9%)

Query: 30  ESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEE--EKEENESH 87
           + + +E  E +K +   +R G    E+E +E E+ +   GEE++ +E E+  +KE N+  
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEG--EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEM 727

Query: 88  KWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEP 147
           +   GEE    G+       +   K+GE     +++ +G  +  + +  EG   R   E 
Sbjct: 728 E-EGGEEEHGEGEEEEGDREEEEEKEGE----GKEEGEGEEVEGEREKEEG--ERKKEER 780

Query: 148 YSEEEEGQESSE--EGSEEDVEA-VDETADGAEVK 179
             +EE+G+E  +  EG EE+ E   +E  +G EV+
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVE 815



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 1/45 (2%)

Query: 50   GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEE 94
            G   EEE E E E+ E  G  EE+    EEE+EE   ++  TGEE
Sbjct: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ-ETGEE 1075



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 38/159 (23%)

Query: 29  SESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHK 88
           +E  LK  L P ++Q   Q +G  T++   +E++DS        D  EE  E +E ++ K
Sbjct: 511 NEKSLK--LSPVQKQKKQQTIGELTQDTALTENDDS--------DEYEEMSEMKEGKACK 560

Query: 89  WSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 148
                ++++ G F  Q    +     E + + E+K      A+D+KGN            
Sbjct: 561 -----QHVSQGIFMTQPATTIEAFSDEEVEIPEEKEG----AEDSKGN------------ 599

Query: 149 SEEEEGQESSEE------GSEEDVEAV-DETADGAEVKQ 180
             EE+  E++EE      G +E  E + D+  D AEV +
Sbjct: 600 GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 35/131 (26%), Positives = 53/131 (40%), Gaps = 17/131 (12%)

Query: 50  GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDL 109
           GA   ++EE E  + +   GE E   E E+E  E E  K   GEE     +   ++ G  
Sbjct: 665 GAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ----EQKEREQGHQ 720

Query: 110 TFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAV 169
             +  E+      +  G     + +  EG       +   EEE+  E  EEG  E+VE  
Sbjct: 721 KERNQEM------EEGGEEEHGEGEEEEG-------DREEEEEKEGEGKEEGEGEEVEGE 767

Query: 170 DETADGAEVKQ 180
            E  +G   K+
Sbjct: 768 REKEEGERKKE 778



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 41/167 (24%), Positives = 71/167 (42%), Gaps = 24/167 (14%)

Query: 28  LSESQLKEALEPNKRQHIYQRVGAPTEE----------EEESESEDSEDSGGEEEDAEEE 77
           +SE +  +A + +  Q I+    A T E          EE+  +EDS+ +G EE++ E  
Sbjct: 550 MSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEAN 609

Query: 78  EEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNE 137
           EE  + +   K  T    I   D T +   +++  K + +   E  P+G       +G+ 
Sbjct: 610 EENVKVHGGRKEKT---EILSDDLTDK--AEVSEGKAKSVGEAEDGPEGRGDGTCEEGSS 664

Query: 138 GLVPRTYLEPYSEEEEGQESSEEG---SEEDVEAVDETADGAEVKQR 181
           G       E + +EE  +   ++G    E   E   E A+  E K+R
Sbjct: 665 G------AEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKR 705



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 1/42 (2%)

Query: 54   EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEY 95
            E E+E E E++  +  EEE+ E + +E  E E+ +   GEEY
Sbjct: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENER-QDGEEY 1085


>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 94  EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 152
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194

Query: 153 EGQESSEEGSEE 164
               +   G++E
Sbjct: 195 ASVSALIGGNQE 206


>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
           [Homo sapiens]
          Length = 204

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)

Query: 94  EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 148
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y
Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 24/54 (44%), Positives = 34/54 (62%), Gaps = 1/54 (1%)

Query: 94  EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 146
           EY+  + DF      DL FKKGEIL++IEK  + WW A++  G  G++P  Y+E
Sbjct: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179


>gi|21735415 centromere protein B [Homo sapiens]
          Length = 599

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 8/133 (6%)

Query: 54  EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 113
           EEEEE E E+ E+  GEEE+ E EEEE+E  E  +    EE    GD  + +  +   + 
Sbjct: 407 EEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEES 466

Query: 114 GEILLVIEKKPDGWWIAKDAKGNEGLVPRT------YLE--PYSEEEEGQESSEEGSEED 165
               L  E    G   A  + G  G           +LE    S+ +  +E  EE  +ED
Sbjct: 467 SSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDED 526

Query: 166 VEAVDETADGAEV 178
            +  D+  DG EV
Sbjct: 527 EDDDDDEEDGDEV 539



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 13/45 (28%), Positives = 25/45 (55%)

Query: 54  EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAV 98
           + + +SE ED E+   E+ED +++EE+ +E     +     Y A+
Sbjct: 509 DSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAM 553



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 12/39 (30%), Positives = 27/39 (69%)

Query: 55  EEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGE 93
           E+ +S+SE+ +D   ++ED +++++E++ +E    S GE
Sbjct: 508 EDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGE 546


>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
          Length = 1105

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)

Query: 93  EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 150
           E+Y+ V ++  Q+  +L+ + GE++ VIEK   GWW    ++  +G VP TYLE    + 
Sbjct: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227

Query: 151 EEEGQESSEEGSEE 164
           ++    +S+ G EE
Sbjct: 228 DDSDINTSKTGEEE 241



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 75  EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 132
           E +   +++++ +   TGEE  Y+ V  +T+Q   ++ F+KG  + VI K  +GWW  + 
Sbjct: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279

Query: 133 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 174
             G EG  P +YL+   ++   ++ +  G  E +  + E ++
Sbjct: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 39/186 (20%), Positives = 76/186 (40%), Gaps = 24/186 (12%)

Query: 29  SESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE--- 85
           +ESQ +E ++ +  +   +  G      + S+SEDSE       +A  E   +  ++   
Sbjct: 737 AESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLIT 796

Query: 86  ----------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAK 134
                       +W      Y+    +   Q  +++F  G  + V+EK+  GWW  +  +
Sbjct: 797 LPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE 856

Query: 135 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAIS 194
             EG  P  YL      +E ++    G E D       A G + + ++D     +++ + 
Sbjct: 857 -LEGWAPSHYL----VLDENEQPDPSGKELDT----VPAKGRQNEGKSD-SLEKIERRVQ 906

Query: 195 EINTVD 200
            +NTV+
Sbjct: 907 ALNTVN 912



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 18/55 (32%), Positives = 30/55 (54%), Gaps = 4/55 (7%)

Query: 95   YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKDAKGNEGLVPRTYLE 146
            Y+++ D+   +     F++G  + V+E+ P+GWW   I    K  +G VP  YLE
Sbjct: 1049 YVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLE 1102



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 94  EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 146
           EY  + +F +     ++F+ G+   VI+K   GWW  +  +  EG  P +Y++
Sbjct: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 229 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 288

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------I 116
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E       +
Sbjct: 289 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHL 345

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
           L+V E + D     +D+  +E        E   E  EG   S   +E D           
Sbjct: 346 LVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPI 392

Query: 177 EVKQRTDPHWSAVQ 190
           E+KQ    +  A+Q
Sbjct: 393 ELKQELPKYLPALQ 406



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 38/195 (19%), Positives = 78/195 (40%), Gaps = 15/195 (7%)

Query: 3   ARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESE 62
           +RR+RD L+ L R+ +           E +++E  +  + Q   +R      +E E+  E
Sbjct: 150 SRRERDRLEQLERKRER----------ERKMREQQKEQREQKERERRAEERRKEREARRE 199

Query: 63  DSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK 122
            S       ED  ++ +    + S      E +  +GD   + V +   ++ ++L  ++ 
Sbjct: 200 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERF-ELGD-GRKPVKEEKMEERDLLSDLQD 257

Query: 123 KPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRT 182
             D     +     E     +      EEEE +E  EEGS  +    +E  +  E ++  
Sbjct: 258 ISDS---ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 314

Query: 183 DPHWSAVQKAISEIN 197
                A +++  E++
Sbjct: 315 SNSEEASEQSAEEVS 329


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------I 116
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E       +
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHL 354

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
           L+V E + D     +D+  +E        E   E  EG   S   +E D           
Sbjct: 355 LVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPI 401

Query: 177 EVKQRTDPHWSAVQ 190
           E+KQ    +  A+Q
Sbjct: 402 ELKQELPKYLPALQ 415



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 40/206 (19%), Positives = 69/206 (33%), Gaps = 62/206 (30%)

Query: 4   RRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R++R+  + +   ++ +++     +  S    +     R+      G    +EE+ E  D
Sbjct: 200 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 259

Query: 64  -----------------SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 106
                            +E S  E     EEEEE+EE E  + ST EE            
Sbjct: 260 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE------------ 307

Query: 107 GDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDV 166
                         E++ +                    E   EEEE   +SEE SE+  
Sbjct: 308 -------------SEEEEE--------------------EEEEEEEETGSNSEEASEQSA 334

Query: 167 EAVDETADGAEVKQRTDPHWSAVQKA 192
           E V E     + ++  + H   V ++
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPES 360


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 206 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 265

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------I 116
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E       +
Sbjct: 266 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHL 322

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
           L+V E + D     +D+  +E        E   E  EG   S   +E D           
Sbjct: 323 LVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPI 369

Query: 177 EVKQRTDPHWSAVQ 190
           E+KQ    +  A+Q
Sbjct: 370 ELKQELPKYLPALQ 383



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 38/195 (19%), Positives = 78/195 (40%), Gaps = 15/195 (7%)

Query: 3   ARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESE 62
           +RR+RD L+ L R+ +           E +++E  +  + Q   +R      +E E+  E
Sbjct: 127 SRRERDRLEQLERKRER----------ERKMREQQKEQREQKERERRAEERRKEREARRE 176

Query: 63  DSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK 122
            S       ED  ++ +    + S      E +  +GD   + V +   ++ ++L  ++ 
Sbjct: 177 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERF-ELGD-GRKPVKEEKMEERDLLSDLQD 234

Query: 123 KPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRT 182
             D     +     E     +      EEEE +E  EEGS  +    +E  +  E ++  
Sbjct: 235 ISDS---ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 291

Query: 183 DPHWSAVQKAISEIN 197
                A +++  E++
Sbjct: 292 SNSEEASEQSAEEVS 306


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 195 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 254

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------I 116
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E       +
Sbjct: 255 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHL 311

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
           L+V E + D     +D+  +E        E   E  EG   S   +E D           
Sbjct: 312 LVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPI 358

Query: 177 EVKQRTDPHWSAVQ 190
           E+KQ    +  A+Q
Sbjct: 359 ELKQELPKYLPALQ 372



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 38/195 (19%), Positives = 78/195 (40%), Gaps = 15/195 (7%)

Query: 3   ARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESE 62
           +RR+RD L+ L R+ +           E +++E  +  + Q   +R      +E E+  E
Sbjct: 116 SRRERDRLEQLERKRER----------ERKMREQQKEQREQKERERRAEERRKEREARRE 165

Query: 63  DSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK 122
            S       ED  ++ +    + S      E +  +GD   + V +   ++ ++L  ++ 
Sbjct: 166 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERF-ELGD-GRKPVKEEKMEERDLLSDLQD 223

Query: 123 KPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRT 182
             D     +     E     +      EEEE +E  EEGS  +    +E  +  E ++  
Sbjct: 224 ISDS---ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280

Query: 183 DPHWSAVQKAISEIN 197
                A +++  E++
Sbjct: 281 SNSEEASEQSAEEVS 295


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 240 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 299

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------I 116
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E       +
Sbjct: 300 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHL 356

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
           L+V E + D     +D+  +E        E   E  EG   S   +E D           
Sbjct: 357 LVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPI 403

Query: 177 EVKQRTDPHWSAVQ 190
           E+KQ    +  A+Q
Sbjct: 404 ELKQELPKYLPALQ 417



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 38/195 (19%), Positives = 78/195 (40%), Gaps = 15/195 (7%)

Query: 3   ARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESE 62
           +RR+RD L+ L R+ +           E +++E  +  + Q   +R      +E E+  E
Sbjct: 161 SRRERDRLEQLERKRER----------ERKMREQQKEQREQKERERRAEERRKEREARRE 210

Query: 63  DSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK 122
            S       ED  ++ +    + S      E +  +GD   + V +   ++ ++L  ++ 
Sbjct: 211 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERF-ELGD-GRKPVKEEKMEERDLLSDLQD 268

Query: 123 KPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRT 182
             D     +     E     +      EEEE +E  EEGS  +    +E  +  E ++  
Sbjct: 269 ISDS---ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 325

Query: 183 DPHWSAVQKAISEIN 197
                A +++  E++
Sbjct: 326 SNSEEASEQSAEEVS 340


>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo
           sapiens]
          Length = 2211

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 35/101 (34%), Positives = 53/101 (52%), Gaps = 17/101 (16%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEE-EESE 60
           L  R+ D       R ++ K ++  LL + +LK  L+  K++    R G+  E+E EE E
Sbjct: 901 LVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKK----RKGSDEEDEGEEEE 956

Query: 61  SEDSEDSGGEEEDAEEEEEEKE------------ENESHKW 89
           S  SE+S  EEE+ EEEEEE+E            + E+H+W
Sbjct: 957 SSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRW 997


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 16/114 (14%)

Query: 54  EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 113
           EEEEE E E+ E+   EEE+ EEEEEE+EE E  +       +A+G+    + G  +  +
Sbjct: 734 EEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSG--SSSE 791

Query: 114 GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 167
           G      E+  D        +  EG  P T L    +E  G+ S  +G  E  E
Sbjct: 792 GS-----ERSTD--------RSQEG-APSTLLADDQKESRGRASMADGDLEPEE 831



 Score = 29.6 bits (65), Expect = 8.5
 Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 7/47 (14%)

Query: 34  KEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEE 80
           KE  E  +     +      EEEEE E E       EEE+ EEEEEE
Sbjct: 732 KEEEEEEEEDEEEEEEDEEEEEEEEEEEE-------EEEEEEEEEEE 771


>gi|20149528 proline-serine-threonine phosphatase interacting
           protein 1 [Homo sapiens]
          Length = 416

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/65 (40%), Positives = 37/65 (56%), Gaps = 1/65 (1%)

Query: 82  EENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVP 141
           +E + +  S  +EY A+ D+TAQ   +L    G+IL VI +  DGWW   +  G  G VP
Sbjct: 351 QEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTV-ERNGQRGFVP 409

Query: 142 RTYLE 146
            +YLE
Sbjct: 410 GSYLE 414


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 43/162 (26%), Positives = 72/162 (44%), Gaps = 19/162 (11%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 228 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 287

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKK 123
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E        
Sbjct: 288 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDE-------- 336

Query: 124 PDGWWIAKDAKGNEGLVPRTYLEPYS-EEEEGQESSEEGSEE 164
                  ++ + +  +VP +  +  S E EE +E   EG+ +
Sbjct: 337 ------ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQ 372



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 49/183 (26%), Positives = 71/183 (38%), Gaps = 22/183 (12%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   + V A      E
Sbjct: 149 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 208

Query: 59  SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTA--QQVGDLTFKKGEI 116
             S+  + S           E  E  +  K    EE +   D  +  Q + D   K    
Sbjct: 209 DYSDKVKASHWSRSPPRPPRERFELGDGRK-PVKEEKMEERDLLSDLQDISDSERKTSSA 267

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEG--QESSEEGSEEDVEAVDETAD 174
               E        A+   G+E        E   EEEEG   E SEE  EE+ E  +ET  
Sbjct: 268 ----ESSS-----AESGSGSE----EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 314

Query: 175 GAE 177
            +E
Sbjct: 315 NSE 317


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 43/162 (26%), Positives = 72/162 (44%), Gaps = 19/162 (11%)

Query: 5   RQRDPLQALRRRNQELKQQVDSLLSESQ-LKEALEPNKRQHIYQRVGAPTEEEEESESED 63
           R+R  L   R+  +E K +   LLS+ Q + ++                  EEEE E E+
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297

Query: 64  SEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKK 123
            E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + E        
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSEDE-------- 346

Query: 124 PDGWWIAKDAKGNEGLVPRTYLEPYS-EEEEGQESSEEGSEE 164
                  ++ + +  +VP +  +  S E EE +E   EG+ +
Sbjct: 347 ------ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQ 382



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 49/183 (26%), Positives = 71/183 (38%), Gaps = 22/183 (12%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   + V A      E
Sbjct: 159 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 218

Query: 59  SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTA--QQVGDLTFKKGEI 116
             S+  + S           E  E  +  K    EE +   D  +  Q + D   K    
Sbjct: 219 DYSDKVKASHWSRSPPRPPRERFELGDGRK-PVKEEKMEERDLLSDLQDISDSERKTSSA 277

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEG--QESSEEGSEEDVEAVDETAD 174
               E        A+   G+E        E   EEEEG   E SEE  EE+ E  +ET  
Sbjct: 278 ----ESSS-----AESGSGSE----EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 324

Query: 175 GAE 177
            +E
Sbjct: 325 NSE 327


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 42/143 (29%), Positives = 63/143 (44%), Gaps = 23/143 (16%)

Query: 55  EEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKG 114
           EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A++V +    + 
Sbjct: 35  EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEVSEEEMSED 91

Query: 115 E-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 167
           E       +L+V E + D     +D+  +E        E   E  EG   S   +E D  
Sbjct: 92  EERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSSALTEGDYV 138

Query: 168 AVDETADGAEVKQRTDPHWSAVQ 190
                    E+KQ    +  A+Q
Sbjct: 139 PDSPALSPIELKQELPKYLPALQ 161



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 11/70 (15%)

Query: 29 SESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEE----------- 77
          S S  +E  E  + +         +EEEEE E E+ E++G   E+A E+           
Sbjct: 30 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 89

Query: 78 EEEKEENESH 87
          E+E+ ENE+H
Sbjct: 90 EDEERENENH 99



 Score = 37.4 bits (85), Expect = 0.041
 Identities = 18/48 (37%), Positives = 26/48 (54%)

Query: 47 QRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEE 94
          Q +     +   +ES  +E   G EE+ EEEEEE+EE  + + S  EE
Sbjct: 11 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 58


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 24/66 (36%), Positives = 37/66 (56%), Gaps = 6/66 (9%)

Query: 80  EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGL 139
           E+E+N        E  +A+ DF A +  DL  ++G+  L++EK    WW A+D  GNEG 
Sbjct: 175 EEEDNSE------EIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGY 228

Query: 140 VPRTYL 145
           +P  Y+
Sbjct: 229 IPSNYV 234


>gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]
          Length = 359

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 13/109 (11%)

Query: 49  VGAPTEEEEESESEDSEDSGGEEEDA---EEEEEEKEENESHKWSTGEE-------YIAV 98
           +  P    +  + E  E+   EEED+   + EE+ K   +S   ++G++       Y  +
Sbjct: 246 ISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGL 305

Query: 99  GDFTAQQVGDLTFKKGEILLVIEKKPD--GWWIAKDAKGNEGLVPRTYL 145
            D T     +L+FK+G+++ ++ K+ +  GWW+  + KG  GLVP+ Y+
Sbjct: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG-EMKGAIGLVPKAYI 353


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 25/52 (48%), Positives = 31/52 (59%)

Query: 54  EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQ 105
           EEEEE E E+ E+   EEE+ EEEEEE+EE E  +    EE  A  D   Q+
Sbjct: 264 EEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/86 (34%), Positives = 45/86 (52%), Gaps = 8/86 (9%)

Query: 10  LQALRRRNQEL-KQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSG 68
           ++    R+Q+L  Q ++   SE       E +K++ I        EEEEE E E+ ++  
Sbjct: 225 VEVTTERSQDLCPQSLEDAASE-------ESSKQKGILSHEEEDEEEEEEEEEEEEDEEE 277

Query: 69  GEEEDAEEEEEEKEENESHKWSTGEE 94
            EEE+ EEEEEE+EE E  +    EE
Sbjct: 278 EEEEEEEEEEEEEEEEEEEEEEEEEE 303



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 35/150 (23%), Positives = 63/150 (42%), Gaps = 8/150 (5%)

Query: 23  QVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKE 82
           +V +  S+    ++LE    +   ++ G  + EEE+ E E+ E+   EE++ EEEEEE+E
Sbjct: 226 EVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEE-EEDEEEEEEEEEE 284

Query: 83  ENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPR 142
           E E  +    EE     +   +   D+ F++       +K P       + +G E   P+
Sbjct: 285 EEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAP-------ELRGPESPSPK 337

Query: 143 TYLEPYSEEEEGQESSEEGSEEDVEAVDET 172
                  E     +  E+         DE+
Sbjct: 338 PEYSVIVEVRSDDDKDEDTHSRKSTVTDES 367



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 5/82 (6%)

Query: 11  QALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGE 70
           Q+L     E   +   +LS  +  E  E  + +          EEEEE E E+ E+   E
Sbjct: 238 QSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEE 297

Query: 71  EEDAEEEEEEK-----EENESH 87
           EE+ EEEEE       +E+ SH
Sbjct: 298 EEEEEEEEEAAPDVIFQEDTSH 319



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 32/136 (23%), Positives = 45/136 (33%), Gaps = 51/136 (37%)

Query: 57  EESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEI 116
           E++ SE+S    G     EE+EEE+EE E  +    EE                      
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE---------------------- 278

Query: 117 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 176
                                        E   EEEE +E  EE  EE+ E  +E     
Sbjct: 279 -----------------------------EEEEEEEEEEEEEEEEEEEEEEEEEEEEAAP 309

Query: 177 EVKQRTDPHWSAVQKA 192
           +V  + D   ++ QKA
Sbjct: 310 DVIFQEDTSHTSAQKA 325


>gi|109689723 abl interactor 2 [Homo sapiens]
          Length = 475

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 13/111 (11%)

Query: 52  PTEEEEESESEDSEDSGGEEEDAEEEEEEKEE------NESHKWSTG---EEYIAVGDFT 102
           P    EE   ++S       ED EEEE    E       E   W+     E+ +A+ D+T
Sbjct: 366 PPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYT 425

Query: 103 AQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEP---YSE 150
             +  +L+F++G I+ VI+K  DGW+      G  GL P  Y+E    YSE
Sbjct: 426 KDKEDELSFQEGAIIYVIKKNDDGWYEGV-MNGVTGLFPGNYVESIMHYSE 475


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 23/57 (40%), Positives = 33/57 (57%)

Query: 32  QLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHK 88
           QL+E LE      +   +    +EEEE E E+ E+   EEE+ +EEEEE+EE E  +
Sbjct: 340 QLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEE 396



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 19/39 (48%), Positives = 26/39 (66%), Gaps = 1/39 (2%)

Query: 54  EEEEESESEDSEDSGGEEEDAE-EEEEEKEENESHKWST 91
           EEEEE+E E+ ED   EEE+ E EEEE ++  +  K +T
Sbjct: 371 EEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSAT 409



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 15/38 (39%), Positives = 20/38 (52%)

Query: 51  APTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHK 88
           A  EEEE+ E E+ E+   EEE  +  + EK    S K
Sbjct: 376 AEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413



 Score = 30.0 bits (66), Expect = 6.5
 Identities = 14/35 (40%), Positives = 20/35 (57%)

Query: 146 EPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQ 180
           E   EEEEG+E  EE  EE+ E  +E  +  E ++
Sbjct: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEE 395


>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
          Length = 545

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 6/101 (5%)

Query: 51  APTEEEEESESEDSEDSGGEEEDAEEEE-----EEKEENESHKWSTGEEYIAVGDFTAQQ 105
           AP +    S S+D+++S  E    E ++     E  E+ E    S     +A+  F    
Sbjct: 440 APPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSS 499

Query: 106 VGDLTFKKGEILLVIEK-KPDGWWIAKDAKGNEGLVPRTYL 145
            G ++  +GE L ++E+ K DGW   +  +G EG VP +YL
Sbjct: 500 EGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYL 540


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,682,471
Number of Sequences: 37866
Number of extensions: 1237437
Number of successful extensions: 31540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 675
Number of HSP's successfully gapped in prelim test: 458
Number of HSP's that attempted gapping in prelim test: 11975
Number of HSP's gapped (non-prelim): 9633
length of query: 614
length of database: 18,247,518
effective HSP length: 108
effective length of query: 506
effective length of database: 14,157,990
effective search space: 7163942940
effective search space used: 7163942940
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.