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Search of human proteins with 188595682
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
(1863 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 3696 0.0
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 3652 0.0
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 2867 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 2115 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 1753 0.0
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 1751 0.0
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 1749 0.0
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 1748 0.0
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 1746 0.0
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens] 937 0.0
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 327 5e-89
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 314 4e-85
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 308 4e-83
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 306 9e-83
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 305 2e-82
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 296 1e-79
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 293 8e-79
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 249 1e-65
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 237 7e-62
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 237 7e-62
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 233 1e-60
gi|34304381 inversin isoform a [Homo sapiens] 209 3e-53
gi|34304379 inversin isoform b [Homo sapiens] 209 3e-53
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 208 5e-53
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 184 7e-46
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 180 1e-44
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 179 2e-44
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 173 2e-42
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 173 2e-42
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 173 2e-42
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 3696 bits (9585), Expect = 0.0
Identities = 1863/1863 (100%), Positives = 1863/1863 (100%)
Query: 1 MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQ 60
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQ
Sbjct: 1 MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQ 60
Query: 61 ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 120
ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN
Sbjct: 61 ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 120
Query: 121 HIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAAR 180
HIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAAR
Sbjct: 121 HIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAAR 180
Query: 181 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 240
KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF
Sbjct: 181 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 240
Query: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
Query: 301 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 360
GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT
Sbjct: 301 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 360
Query: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM
Sbjct: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
Query: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 481 HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540
HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK
Sbjct: 481 HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540
Query: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Query: 661 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV
Sbjct: 661 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
Query: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA
Sbjct: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Query: 781 KRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEY 840
KRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEY
Sbjct: 781 KRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEY 840
Query: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAV 900
LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAV
Sbjct: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAV 900
Query: 901 MDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFL 960
MDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFL
Sbjct: 901 MDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFL 960
Query: 961 VSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASR 1020
VSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASR
Sbjct: 961 VSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASR 1020
Query: 1021 LIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRG 1080
LIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRG
Sbjct: 1021 LIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRG 1080
Query: 1081 KERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQ 1140
KERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQ
Sbjct: 1081 KERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQ 1140
Query: 1141 YFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKI 1200
YFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKI
Sbjct: 1141 YFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKI 1200
Query: 1201 LGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTT 1260
LGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTT
Sbjct: 1201 LGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTT 1260
Query: 1261 PAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAK 1320
PAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAK
Sbjct: 1261 PAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAK 1320
Query: 1321 FVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNL 1380
FVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNL
Sbjct: 1321 FVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNL 1380
Query: 1381 VPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLN 1440
VPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLN
Sbjct: 1381 VPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLN 1440
Query: 1441 ITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFT 1500
ITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFT
Sbjct: 1441 ITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFT 1500
Query: 1501 EEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTE 1560
EEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTE
Sbjct: 1501 EEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTE 1560
Query: 1561 PLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSE 1620
PLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSE
Sbjct: 1561 PLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSE 1620
Query: 1621 EDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFV 1680
EDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFV
Sbjct: 1621 EDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFV 1680
Query: 1681 TTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSE 1740
TTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSE
Sbjct: 1681 TTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSE 1740
Query: 1741 HREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHT 1800
HREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHT
Sbjct: 1741 HREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHT 1800
Query: 1801 VVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSED 1860
VVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSED
Sbjct: 1801 VVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSED 1860
Query: 1861 NNE 1863
NNE
Sbjct: 1861 NNE 1863
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 3652 bits (9471), Expect = 0.0
Identities = 1845/1858 (99%), Positives = 1846/1858 (99%), Gaps = 12/1858 (0%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL
Sbjct: 267 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD
Sbjct: 327 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV
Sbjct: 867 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
Query: 906 VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMV 965
VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG FLVSFMV
Sbjct: 927 VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG------------FLVSFMV 974
Query: 966 DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1025
DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG
Sbjct: 975 DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1034
Query: 1026 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1085
PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL
Sbjct: 1035 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1094
Query: 1086 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1145
VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV
Sbjct: 1095 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1154
Query: 1146 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1205
SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA
Sbjct: 1155 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1214
Query: 1206 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1265
TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE
Sbjct: 1215 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1274
Query: 1266 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1325
DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA
Sbjct: 1275 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1334
Query: 1326 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1385
KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK
Sbjct: 1335 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1394
Query: 1386 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1445
SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI
Sbjct: 1395 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1454
Query: 1446 YTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIH 1505
YTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIH
Sbjct: 1455 YTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIH 1514
Query: 1506 QIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQER 1565
QIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQER
Sbjct: 1515 QIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQER 1574
Query: 1566 ISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISV 1625
ISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISV
Sbjct: 1575 ISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISV 1634
Query: 1626 GYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGT 1685
GYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGT
Sbjct: 1635 GYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGT 1694
Query: 1686 ETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREES 1745
ETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREES
Sbjct: 1695 ETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREES 1754
Query: 1746 SPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKV 1805
SPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKV
Sbjct: 1755 SPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKV 1814
Query: 1806 TRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE 1863
TRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Sbjct: 1815 TRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE 1872
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 2867 bits (7431), Expect = 0.0
Identities = 1499/1747 (85%), Positives = 1549/1747 (88%), Gaps = 43/1747 (2%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL
Sbjct: 267 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD
Sbjct: 327 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV
Sbjct: 867 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
Query: 906 VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMV 965
VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG FLVSFMV
Sbjct: 927 VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG------------FLVSFMV 974
Query: 966 DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1025
DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG
Sbjct: 975 DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1034
Query: 1026 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1085
PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL
Sbjct: 1035 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1094
Query: 1086 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1145
VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV
Sbjct: 1095 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1154
Query: 1146 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1205
SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA
Sbjct: 1155 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1214
Query: 1206 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1265
TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE
Sbjct: 1215 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1274
Query: 1266 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1325
DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA
Sbjct: 1275 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1334
Query: 1326 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1385
KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK
Sbjct: 1335 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1394
Query: 1386 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1445
SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI
Sbjct: 1395 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1454
Query: 1446 YTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLG-FSWTELARELDFTEEQI 1504
YTKESESDQEQEEEIDMTSEKN + E +++ + + + +L E+ ++ +
Sbjct: 1455 YTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
Query: 1505 HQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQE 1564
++ + D++ ++ L + + +IV ++ + E + E
Sbjct: 1515 IKMTAILTTDVSDKAGSIKVKELVKAAEEEPG----------EPFEIVERVKEDLEKVNE 1564
Query: 1565 RI-SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDI 1623
+ S + E ++ SE +++EE ++ EE E ++P + D
Sbjct: 1565 ILRSGTCTRDESSVQSSRSER-GLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDK 1623
Query: 1624 SVGYSTFQDG---VPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFV 1680
+ +D V D + P+ + VQ K + L S E + +
Sbjct: 1624 EIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK--- 1680
Query: 1681 TTPGTETSETQKAMIVPSSPSKTP-----------EEVSTPAEEEKLYLQTPTSSERGGS 1729
P ET TQK PS K P +E A EK L+ +S E G
Sbjct: 1681 DIPPDETQSTQK-QHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGE 1739
Query: 1730 PIIQEPE 1736
PE
Sbjct: 1740 DPGLAPE 1746
Score = 803 bits (2073), Expect = 0.0
Identities = 418/509 (82%), Positives = 436/509 (85%), Gaps = 25/509 (4%)
Query: 1376 CFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLS-------FMKEPKST 1428
C G P +S +H FF N + F ++ D + RL+ + + +S+
Sbjct: 3453 CRGGTSPTKESKEH----FFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESS 3508
Query: 1429 RGLVHQAICNL-------NITLPIYTKESESDQEQEEEIDMTSEKN-------PQDEQER 1474
L I NL ++ I+ D+ E I+ ++N PQDEQER
Sbjct: 3509 SALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQER 3568
Query: 1475 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 1534
IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA
Sbjct: 3569 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 3628
Query: 1535 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 1594
TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT
Sbjct: 3629 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 3688
Query: 1595 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 1654
AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ
Sbjct: 3689 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 3748
Query: 1655 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 1714
VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE
Sbjct: 3749 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 3808
Query: 1715 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 1774
KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF
Sbjct: 3809 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 3868
Query: 1775 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 1834
EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV
Sbjct: 3869 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 3928
Query: 1835 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 1863
NIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Sbjct: 3929 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 3957
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 2115 bits (5480), Expect = 0.0
Identities = 1061/1477 (71%), Positives = 1234/1477 (83%), Gaps = 84/1477 (5%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+KSD+NAS+LRAARAG+L+K ++Y+K G+DIN CNQNGLNALHLA+KEGHV +V ELL R
Sbjct: 37 KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
++VD+ATKKGNTALHIASLAGQAEVVKVLV GAN+NAQSQNGFTPLYMAAQENH++VV
Sbjct: 97 EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LL+NGA+QS ATEDGFTPLAVALQQGH+Q V++LLENDTKGKVRLPALHIAARKDDTK
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AALLLQND+NADV+SK SGFTPLHIAAHYGN+NVATLLLNR AAVDFTARN
Sbjct: 217 AAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLHVASKRGN NMVKLLLDRG +IDAKTRDGLTPLHC ARSGH+QVVE+LL+R AP+L
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
++TKNGLSPLHMA QGDH+ CV+ LLQH PVDDVT DYLTALHVAAHCGHY+V K+LLD
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K+ANPNA+ALNGFTPLHIACKKNRIKVMELL+K+GASIQA+TESGLTPIHVAAFMGH+NI
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V L+ +GASP+ TN+RGETALHMAAR+GQ EVVR L+++GA V+A+A+++QTPLHI++R
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
LGK +IVQ LLQ A P+AATT+GYTPLH+SAREG DVA+ LL+ GA+ S+ TKKGFTP
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG L+VA LLLQ+ A+ D+AGK+GLTPLHVAAHYDNQKVALLLL++GASPHA A
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
KNGYTPLHIAAKKNQM IA+TLL YGA+ N VT+QG+ +HLA+QEGH DMV+LLL + A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N+++S KSGLT LHLAAQED+VNVA++L GA DA TK+GYTPL V CHYGN+K+VNF
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A VNAKTKNGYTPLHQAAQQGHTHIINVLLQ+ A PN T NGNTAL IA+RLGY
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSD------------------- 826
ISVVDTLK+VTEE T TTTT+TEKHK+NVPETM EVLD+SD
Sbjct: 809 ISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYIS 867
Query: 827 --EEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSD 884
EEG+D MTGD +YL P+DLKELGDDSLP+ Y+ +SL G RS SLRSFSSD
Sbjct: 868 DVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSD 920
Query: 885 RSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPI 943
RS+TL+ +SY RDS ++++ +V Q T +E + +S R SW + LDNV L SSPI
Sbjct: 921 RSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPI 980
Query: 944 HSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRH 1003
HSG FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH
Sbjct: 981 HSG------------FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRH 1028
Query: 1004 RLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTK 1063
+LA PPP+ EGE L SR++++GP G +
Sbjct: 1029 KLAN---------------------------------PPPMVEGEGLASRLVEMGPAGAQ 1055
Query: 1064 FLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPE 1123
FLGPVIVEIPHF ++RGKEREL+VLRSENG++WKEH D ++L E+LNGMDE LDSPE
Sbjct: 1056 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 1115
Query: 1124 DLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRI 1183
+L KKRICRIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRI
Sbjct: 1116 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 1175
Query: 1184 RVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFG 1243
RVGLQAQP+ E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP S + + NG+
Sbjct: 1176 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 1235
Query: 1244 GDA-PTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESV 1302
GD P LRLLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V
Sbjct: 1236 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 1295
Query: 1303 TFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSR 1362
A+Q+YRE+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+
Sbjct: 1296 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 1355
Query: 1363 DVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFM 1422
D+EVLEGKPIYVDC+GNL PLTK GQ +F+F++FKENRLP +K+RDT+QEPCGRLSF+
Sbjct: 1356 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 1415
Query: 1423 KEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEE 1459
KEPK+T+GL A+CNLNITLP + KE+ESDQ+ E E
Sbjct: 1416 KEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIE 1452
Score = 113 bits (282), Expect = 2e-24
Identities = 58/113 (51%), Positives = 77/113 (68%), Gaps = 4/113 (3%)
Query: 1444 PIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQ 1503
P+ +K ++ E+ + PQ ER + R+A +ADHLG SWTELAREL+F+ ++
Sbjct: 4063 PLKSKSEKAGSEKRS----SRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDE 4118
Query: 1504 IHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
I+QIR+ENPNSL QS LLK W+ RDGK+AT L LTKINR+DIV L+E
Sbjct: 4119 INQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLE 4171
Score = 32.0 bits (71), Expect = 5.8
Identities = 64/299 (21%), Positives = 109/299 (36%), Gaps = 41/299 (13%)
Query: 1569 SYAEIEQTITLDHSEGFSVLQEELCTAQHKQKE--EQAVSKES---ETCDHPPIVSEEDI 1623
+Y+EI + G EE T+ K + E + KES + DH PI E +
Sbjct: 3018 TYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGLEKL 3077
Query: 1624 SVGYSTFQDGVPKTEGDSSATAL-----FPQTHKE---QVQQD-----FSGKMQDLPEES 1670
+ + +TEG L F Q K+ ++QQ S + + + E
Sbjct: 3078 AP--------LAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQECKTVQETR 3129
Query: 1671 SLEY---QQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSER- 1726
Y QQ+ + G+ +T + + S K+P TP+ EE Y T + +
Sbjct: 3130 GTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYEFTSKTPDSL 3189
Query: 1727 -----GGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGD--- 1778
G I E E SE E++ VE + E + +D+ +
Sbjct: 3190 IAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQRPKNNRV 3249
Query: 1779 ---DMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 1834
+ P PP + E +H + K+V + + + E +++ P PV
Sbjct: 3250 AYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPPSPV 3308
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 1753 bits (4540), Expect = 0.0
Identities = 912/1597 (57%), Positives = 1161/1597 (72%), Gaps = 85/1597 (5%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+K+D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 221 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG +T G E + +
Sbjct: 813 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKA 870
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
+ D + LD F + + R M ++V
Sbjct: 871 ERRDSRDVDEEKELLD-------------------FVPKLDQVVESPAIPRIPCAMPETV 911
Query: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 912 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 959
Query: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 960 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 1019
Query: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 1020 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1046
Query: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1047 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1106
Query: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1107 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1166
Query: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1167 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1226
Query: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1227 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1286
Query: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1287 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1346
Query: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1347 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1405
Query: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1406 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1465
Query: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1466 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1525
Query: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 1592
+ + + + + + +++ G+S LQ+EL
Sbjct: 1526 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL 1562
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/48 (39%), Positives = 30/48 (62%)
Query: 1776 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1823
+G++ IP E VTEE++ DE G+ V KK+ RK++R+ S +E
Sbjct: 1839 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1886
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 1751 bits (4535), Expect = 0.0
Identities = 975/1954 (49%), Positives = 1280/1954 (65%), Gaps = 192/1954 (9%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
R S + L F + + R M ++V
Sbjct: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
Query: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 919 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
Query: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 979 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
Query: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
Query: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
Query: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
Query: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
Query: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
Query: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
Query: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
Query: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
Query: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL-------CTAQHKQKEEQ----- 1603
+ + + + + + +++ G+S LQ+EL C + +Q
Sbjct: 1485 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEV 1544
Query: 1604 -------AVSKESETCDH------------PPIVSEEDISVGYSTFQDGVP-----KTEG 1639
+ E +T P +V+ ED S+ S +D K EG
Sbjct: 1545 AVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEG 1604
Query: 1640 DSSATALFPQ------THKEQVQQDFSGKMQDLPEESSLEYQQEYFV-------TTPGTE 1686
S P+ + V D + + DL E+ + +E T +
Sbjct: 1605 ALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQ 1664
Query: 1687 TSETQKAMI-------VPSSPSKTPEEVSTPAEEEKL-----------YLQTPTSSE--- 1725
SE + +++ + S T +V T +++L YLQ
Sbjct: 1665 DSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDRLQDWDADGSIVSYLQDAAQGSWQE 1723
Query: 1726 --RGGSPIIQEPEEPSEHREESSPRKTSLVIVESADN----QPET-CERLDEDAAFEKGD 1778
G Q +E E ++ V+V +++ QPE + D D + +
Sbjct: 1724 EVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQE 1783
Query: 1779 DMPEIPPETVTE------------EEYIDE-----HGHTVVKKVTRKIIRRYVSSE---G 1818
+ + T T+ E+ +E G+ V KK+ RK++R+ S
Sbjct: 1784 EQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAA 1843
Query: 1819 TEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLK 1852
E EE+ ++G +P ++ EG ++++KR LK
Sbjct: 1844 QEHEEVELRGSGLQP-DLIEGRKGAQIVKRASLK 1876
Score = 348 bits (892), Expect = 4e-95
Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)
Query: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+V F + T A++ GN + L G I+ ++GL LH A++ GH ++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
LL + L TK G + LH+AA E V+ L+ + A V+ + T L++AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416
V K LL+ AN N +GFTPL +A ++ V+ L+ YG + L +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
AA +LLQN +PDV + G T LH+AA + V + LL GA V+ +
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
TPLHIASR G +V+LLL A + T + TPLH +AR G V ++ +LL+ GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
TK G +P+H+AA+ LD +LLLQ A D + LTPLHVAAH + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
KGA P++ A NG+TPLHIA KKN +++ LL GA + VT+ G+TPLH+AS GH +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
V LL +GA+ ++S T LH+AA+ VA L ++ A +A K TPL A
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
G+ MV LL+ AN N T G+TPLH AA++GH + LL+ A T G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 777 LAIAKRLGYISVVDTL 792
L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 1749 bits (4530), Expect = 0.0
Identities = 971/1939 (50%), Positives = 1271/1939 (65%), Gaps = 191/1939 (9%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
R S + L F + + R M ++V
Sbjct: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
Query: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 919 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
Query: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 979 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
Query: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
Query: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
Query: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
Query: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
Query: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
Query: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
Query: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
Query: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
Query: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL-------CTAQHKQKEEQ----- 1603
+ + + + + + +++ G+S LQ+EL C + +Q
Sbjct: 1485 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEV 1544
Query: 1604 -------AVSKESETCDH------------PPIVSEEDISVGYSTFQDGVP-----KTEG 1639
+ E +T P +V+ ED S+ S +D K EG
Sbjct: 1545 AVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEG 1604
Query: 1640 DSSATALFPQ------THKEQVQQDFSGKMQDLPEESSLEYQQEYFV-------TTPGTE 1686
S P+ + V D + + DL E+ + +E T +
Sbjct: 1605 ALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQ 1664
Query: 1687 TSETQKAMI-------VPSSPSKTPEEVSTPAEEEKL-----------YLQTPTSSE--- 1725
SE + +++ + S T +V T +++L YLQ
Sbjct: 1665 DSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDRLQDWDADGSIVSYLQDAAQGSWQE 1723
Query: 1726 --RGGSPIIQEPEEPSEHREESSPRKTSLVIVESADN----QPET-CERLDEDAAFEKGD 1778
G Q +E E ++ V+V +++ QPE + D D + +
Sbjct: 1724 EVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQE 1783
Query: 1779 DMPEIPPETVTE------------EEYIDE-----HGHTVVKKVTRKIIRRYVSSE---G 1818
+ + T T+ E+ +E G+ V KK+ RK++R+ S
Sbjct: 1784 EQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAA 1843
Query: 1819 TEKEEIMVQGMPQEPVNIE 1837
E EE+ V+G ++P +E
Sbjct: 1844 QEHEEVTVEGPLEDPSELE 1862
Score = 348 bits (892), Expect = 4e-95
Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)
Query: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+V F + T A++ GN + L G I+ ++GL LH A++ GH ++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
LL + L TK G + LH+AA E V+ L+ + A V+ + T L++AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416
V K LL+ AN N +GFTPL +A ++ V+ L+ YG + L +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
AA +LLQN +PDV + G T LH+AA + V + LL GA V+ +
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
TPLHIASR G +V+LLL A + T + TPLH +AR G V ++ +LL+ GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
TK G +P+H+AA+ LD +LLLQ A D + LTPLHVAAH + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
KGA P++ A NG+TPLHIA KKN +++ LL GA + VT+ G+TPLH+AS GH +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
V LL +GA+ ++S T LH+AA+ VA L ++ A +A K TPL A
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
G+ MV LL+ AN N T G+TPLH AA++GH + LL+ A T G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 777 LAIAKRLGYISVVDTL 792
L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 1748 bits (4528), Expect = 0.0
Identities = 908/1597 (56%), Positives = 1158/1597 (72%), Gaps = 93/1597 (5%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
R S + L F + + R M ++V
Sbjct: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
Query: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 919 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
Query: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 979 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
Query: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
Query: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
Query: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
Query: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
Query: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
Query: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
Query: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
Query: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
Query: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 1592
+ + + + + + +++ G+S LQ+EL
Sbjct: 1485 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL 1521
Score = 348 bits (892), Expect = 4e-95
Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)
Query: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+V F + T A++ GN + L G I+ ++GL LH A++ GH ++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
LL + L TK G + LH+AA E V+ L+ + A V+ + T L++AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416
V K LL+ AN N +GFTPL +A ++ V+ L+ YG + L +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
AA +LLQN +PDV + G T LH+AA + V + LL GA V+ +
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
TPLHIASR G +V+LLL A + T + TPLH +AR G V ++ +LL+ GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
TK G +P+H+AA+ LD +LLLQ A D + LTPLHVAAH + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
KGA P++ A NG+TPLHIA KKN +++ LL GA + VT+ G+TPLH+AS GH +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
V LL +GA+ ++S T LH+AA+ VA L ++ A +A K TPL A
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
G+ MV LL+ AN N T G+TPLH AA++GH + LL+ A T G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 777 LAIAKRLGYISVVDTL 792
L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/48 (39%), Positives = 30/48 (62%)
Query: 1776 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1823
+G++ IP E VTEE++ DE G+ V KK+ RK++R+ S +E
Sbjct: 1798 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1845
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 1746 bits (4523), Expect = 0.0
Identities = 955/1846 (51%), Positives = 1243/1846 (67%), Gaps = 167/1846 (9%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
Query: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
R S + L F + + R M ++V
Sbjct: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
Query: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 919 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
Query: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 979 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
Query: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
Query: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
Query: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
Query: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
Query: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
Query: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
Query: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
Query: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
Query: 1557 TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPP 1616
+ R S + + D+S S + H++ + + H P
Sbjct: 1485 GS-----GRQSRNLKPDRRHTDRDYSLSPSQMN------GHQRGQARIT--------HSP 1525
Query: 1617 IVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQ 1676
VS+ QD + + D S + + Q++ + S++
Sbjct: 1526 TVSQVT-----ERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGL 1580
Query: 1677 EYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQTPTSSERGGSPIIQE 1734
E PG + E +K ++ S + T PE S+ A+ ++ ++G +QE
Sbjct: 1581 E-----PG-GSQEYEKVLVSVSEHTWTEQPEAESSQADRDR--------RQQGQEEQVQE 1626
Query: 1735 PEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYI 1794
+ T +V+ + Q E++ E E T+E+
Sbjct: 1627 ------------AKNTFTQVVQGNEFQNIPGEQVTE---------------EQFTDEQ-- 1657
Query: 1795 DEHGHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQGMPQEPVNIE 1837
G+ V KK+ RK++R+ S E EE+ V+G ++P +E
Sbjct: 1658 ---GNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELE 1700
Score = 348 bits (892), Expect = 4e-95
Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)
Query: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+V F + T A++ GN + L G I+ ++GL LH A++ GH ++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
LL + L TK G + LH+AA E V+ L+ + A V+ + T L++AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416
V K LL+ AN N +GFTPL +A ++ V+ L+ YG + L +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
AA +LLQN +PDV + G T LH+AA + V + LL GA V+ +
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
TPLHIASR G +V+LLL A + T + TPLH +AR G V ++ +LL+ GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
TK G +P+H+AA+ LD +LLLQ A D + LTPLHVAAH + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
KGA P++ A NG+TPLHIA KKN +++ LL GA + VT+ G+TPLH+AS GH +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
V LL +GA+ ++S T LH+AA+ VA L ++ A +A K TPL A
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
G+ MV LL+ AN N T G+TPLH AA++GH + LL+ A T G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 777 LAIAKRLGYISVVDTL 792
L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555
>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
Length = 1001
Score = 937 bits (2421), Expect = 0.0
Identities = 525/1009 (52%), Positives = 658/1009 (65%), Gaps = 128/1009 (12%)
Query: 828 EGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSH 887
+ +D MTGD +YL P+DLKELGDDSLP+ Y+ +SL G RS SLRSFSSDRS+
Sbjct: 5 QSEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSDRSY 57
Query: 888 TLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPIHSG 946
TL+ +SY RDS ++++ +V Q T +E + +S R SW + LDNV L SSPIHSG
Sbjct: 58 TLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG 117
Query: 947 RASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLA 1006
FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA
Sbjct: 118 ------------FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLA 165
Query: 1007 TMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLG 1066
PPP+ EGE L SR++++GP G +FLG
Sbjct: 166 N---------------------------------PPPMVEGEGLASRLVEMGPAGAQFLG 192
Query: 1067 PVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLE 1126
PVIVEIPHF ++RGKEREL+VLRSENG++WKEH D ++L E+LNGMDE LDSPE+L
Sbjct: 193 PVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELG 252
Query: 1127 KKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVG 1186
KKRICRIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVG
Sbjct: 253 KKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVG 312
Query: 1187 LQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA 1246
LQAQP+ E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP S + + NG+ GD
Sbjct: 313 LQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDT 372
Query: 1247 -PTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFA 1305
P LRLLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V A
Sbjct: 373 TPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLA 432
Query: 1306 SQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVE 1365
+Q+YRE+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+E
Sbjct: 433 TQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIE 492
Query: 1366 VLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEP 1425
VLEGKPIYVDC+GNL PLTK GQ +F+F++FKENRLP +K+RDT+QEPCGRLSF+KEP
Sbjct: 493 VLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEP 552
Query: 1426 KSTRGLVHQAICNLNITLPIYTKESESDQEQ-------EEEIDMTSE--KNPQDEQERIE 1476
K+T+GL A+CNLNITLP + K ++D+ Q + +E +PQ ER +
Sbjct: 553 KTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTD 612
Query: 1477 ERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATD 1536
R+A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL QS LLK W+ RDGK+AT
Sbjct: 613 IRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATT 672
Query: 1537 TNLVECLTKINRMDIVHLMETNTEPLQE--RIS--HSYAEIEQTITLDHSEGFSVLQEEL 1592
L LTKINR+DIV L+E P+ + IS S+A+ E + D +G+ LQ EL
Sbjct: 673 DALTSVLTKINRIDIVTLLE---GPIFDYGNISGTRSFAD-ENNVFHDPVDGYPSLQVEL 728
Query: 1593 CTA-----------QHKQKEEQAVSKES--------------------ETCDHPPIVSEE 1621
T Q S ES + D PP+V+ E
Sbjct: 729 ETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAE 788
Query: 1622 DISVGYSTFQDGVPKTE--------------------GDSSATALFPQTHKEQVQQDFSG 1661
D S+ S +D VP TE ++S+ L +V
Sbjct: 789 DASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLD 848
Query: 1662 KMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQ 1719
++ D P++ + Y G + I P + +K+ PE + ++
Sbjct: 849 RLDDSPDQCR-DSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETL 907
Query: 1720 TPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERL 1768
P + GS ++EP P ++S + L+I E+ P + +++
Sbjct: 908 KP---KIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKM 953
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 327 bits (839), Expect = 5e-89
Identities = 248/808 (30%), Positives = 385/808 (47%), Gaps = 43/808 (5%)
Query: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
RA + + + V LK D+N ++N LH+AA V + L+ S+V+ + +
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
Query: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
G TALH A+ +G E+VK+L+ GANINA + ++ AA HI+VVK L+ +GA
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Query: 136 STATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALL 190
+ + +TPL A G V LL+ N+ P LH+A
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP-LHVACYNGQDVVV--- 255
Query: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPL 249
N + +VN+ E GFTPLH AA + + LL+ GA V+ +++G TPL
Sbjct: 256 -----NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
H+ + G + + ++ G ID + ++G TPLH AAR GH+ ++ L+ GA R
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
Query: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
+G+ PLH+AA +C + LL +D T LH AA G+ LLL+ A+
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
Query: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL-L 428
N + G +PLH A + + LV GAS+ + E G TP+H AA L
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
Query: 429 LLQNGASPDVTNIRGETALHMAARAGQ------------VEVVRCLLRNGALVDARAREE 476
LL+N A+P + + +G A+H +A G ++V+ L D+ R
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
+PLH+A+ G + +++L+Q + D ++G TPL ++A +G V+ VL+ GA S
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--S 608
Query: 537 LATKKGF---TPLHVAAKYGSLDVAKLLL---QRRAAADSAGKNGLTPLHVAAHYDNQKV 590
+ K TP+H AA G + +LL+ + + A D NG TPL ++ +
Sbjct: 609 ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668
Query: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
LL KGA+ A K G T LH A + LL +GA+ + +G TP+HL++
Sbjct: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728
Query: 651 EGHTDMVTLLLDKGANIHMSTKS----GLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 706
GH ++ LL A++ + + G T+LH A ++L + Q
Sbjct: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN- 787
Query: 707 GYTPLIVACHYGNVKMVNFLLKQ-GAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 764
++PL A N L+ GA+ VNA G TPLH AA H + +LL H A
Sbjct: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
Query: 765 KPNATTANGNTALAIAKRLGYISVVDTL 792
+ N+ + G T L +A G + V+ L
Sbjct: 848 QVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 313 bits (803), Expect = 8e-85
Identities = 246/764 (32%), Positives = 386/764 (50%), Gaps = 46/764 (6%)
Query: 15 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73
L AA + + VV+YL G+D+N N G LH+A G +V EL+ G+ V+
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
Query: 74 KKGNTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
+KG T LH A+ + + +++LV GA++N +S++G TPL+M A + ++++G
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAA 188
A ++G TPL +A + GH + L+ + DT +G + LH+AA +
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
Query: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
LL + + D + G T LH AA GN+ LLLN GA + + G +P
Sbjct: 390 KLLSSGFDIDTPD--------DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Query: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGAPLLAR 307
LH A+ N + L+ G ++ G TPLH AA S D + +E LL A R
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
Query: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--------DVTLDY-----LTALHVAAHC 354
K G + +H +A H C++ L+ + P+D D+ D ++ LH+AA+
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560
Query: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL--T 412
GH++ ++L+ + + R +G TPL +A K ++ +++L+ GASI + + L T
Sbjct: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKRT 619
Query: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNGALV 469
PIH AA GH + LL+ N + +I+ G+T L ++ G + V LL GA V
Sbjct: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
Query: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529
DA+ + +T LH + G E V LLQH A + G TP+H+SA G + V LL
Sbjct: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
Query: 530 EAGAAH----SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
++ A+ + A G+T LH A G +LLL++ + G N +PLH A
Sbjct: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVIN 798
Query: 586 DNQKVALLLLEK-GAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
DN+ A +L++ GAS +AT G TPLH AA + ++ LL++ A+ N V G T
Sbjct: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858
Query: 644 PLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD- 701
PL +A++ G T+ V +L+ A + + S T+LHLA + A ++ + D++
Sbjct: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918
Query: 702 --AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
A TPL VA G +V LL +GA+V A +NGYTP
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 297 bits (761), Expect = 6e-80
Identities = 236/777 (30%), Positives = 363/777 (46%), Gaps = 38/777 (4%)
Query: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
S ++A G+ D+V + D+N + LH AA G +++ L+ G+ V++
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
K T LH A + E V+VL+K A++NA+ +N TPL++AA + + L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAA 188
+N + + G T L A GH + V +LL K A+H AA +
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
LL+ H A+V K + +TPLH AA G ++V LL+ G ++ G TP
Sbjct: 191 LLV--SHGAEVTCK------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
Query: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLAR 307
LHVA G +V L+D G ++ K G TPLH AA S H + +ELL+ GA + +
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
Query: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
+K+G +PLHM A + ++Q A +D + T LH+AA GH + L+
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Query: 368 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
A+ R ++G PLH+A L+ G I + G T +H AA G+L +
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
Query: 428 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 487
LLL GA + + G + LH AA + + L+ +GA V+ TPLH A+
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
Query: 488 KT-EIVQLLLQHMAHPDAATTNGYTPLHISAREG---------QVDVASVLLEAGAAHSL 537
+ ++ LL++ A+P GY +H SA G VL+E L
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
Query: 538 A---TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
+ + +PLH+AA +G ++L+Q D +G TPL +AA + + +L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Query: 595 LEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLA 648
+ +GAS K+ TP+H AA + L+ N V Q G TPL L+
Sbjct: 603 INQGAS--ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
GHTD V LL+KGAN+ K G T+LH A D L +HGA G
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 709 TPLIVACHYGNVKMVNFLLKQGANVNAK----TKNGYTPLHQAAQQGHTHIINVLLQ 761
TP+ ++ G++ ++ LL+ A+++A +GYT LH A GH + +LL+
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
Score = 277 bits (708), Expect = 8e-74
Identities = 217/702 (30%), Positives = 305/702 (43%), Gaps = 92/702 (13%)
Query: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234
LH AA D + LL + S VN TPLH A + +LL
Sbjct: 45 LHAAAYLGDAEIIELL--------ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
Query: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
A V+ +N TPLH+A+ + L+ ++ R G T LH AA SGH ++V
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
Query: 295 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
+LLL RGA + A K +H AA H+E VK L+ H A V T LH AA
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Query: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
G V K LLD + N G TPLH+AC + V+ L+ GA + E G TP+
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Query: 415 HVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
H AA H + L LL+ NGA ++ + G+T LHM A G+ + ++++GA++D
Sbjct: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
Query: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
+ TPLHIA+R G ++ L+ A +G PLH++A G D LL +G
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593
G T LH AA G+L+ LLL A + K G +PLH AA N +
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
Query: 594 LLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAETNIVTKQG----------- 641
L+ GAS + + G TPLH AA + + LL A I KQG
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
Query: 642 ----------------------------------VTPLHLASQEGHTDMVTLLLDKGANI 667
++PLHLA+ GH + +L+ ++
Sbjct: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
Query: 668 HMSTKSGLTSLHLAAQEDKVNVADILTK-----------------HGADQDAHTKL---- 706
+ SG T L LAA + V D+L H A + H++
Sbjct: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
Query: 707 ----------------GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 750
G TPL+++ G+ V LL +GANV+AK K G T LH+ A
Sbjct: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696
Query: 751 GHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
GH ++ LLQHGAK + G T + ++ G+I V+ L
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Score = 261 bits (666), Expect = 6e-69
Identities = 183/584 (31%), Positives = 289/584 (49%), Gaps = 14/584 (2%)
Query: 223 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 282
G+ + L+ + V+F TPLH A+ G+ +++LL+ G +++AK LTPL
Sbjct: 19 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
Query: 283 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 342
H A S ++ V++LL+ A + AR KN +PLH+AA V+C + L+ + V+
Sbjct: 79 HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
Query: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
TALH AA GH + KLLL + AN NA +H A I+V++LLV +GA
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
Query: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
+ + TP+H AA G +++V LL G + N G T LH+A GQ VV L
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
Query: 463 LRNGALVDARAREEQTPLHIASRLGKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQ 521
+ GA+V+ + + TPLH A+ + ++LL+ + A + + +G TPLH++A G+
Sbjct: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
Query: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
+ ++++GA K G TPLH+AA+YG + L+ A G +G+ PLH+
Sbjct: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
Query: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 641
AA LL G G T LH AA ++ + LLN GA+ N K G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED-KVNVADILTKHGADQ 700
+PLH A+ + + L+ GA+++ + G T LH AA D + L ++ A+
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
Query: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQ----------GANVNAKTKNGYT--PLHQAA 748
K GY + + YG+ + + + G ++ + + N T PLH AA
Sbjct: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
Query: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
GH + VL+Q + ++G T L +A G++ VD L
Sbjct: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Score = 244 bits (622), Expect = 7e-64
Identities = 212/712 (29%), Positives = 330/712 (46%), Gaps = 59/712 (8%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
++ D A G + ++ G I+ ++NG LH+AA+ GH L+ L+
Sbjct: 301 MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
Query: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
G+ G LH+A+L+G ++ + L+ G +I+ G T L+ AA +++
Sbjct: 361 SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420
Query: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL-----ENDTKGKVRLPALHIAA 179
+ LL GA+ + + G +PL A + Q + L+ ND + P LH AA
Sbjct: 421 LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTP-LHYAA 479
Query: 180 RKD-DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
D D K LL+ND N ++ K G+ +H +A YG+ L+ +
Sbjct: 480 TSDTDGKCLEYLLRNDANPGIRDK--------QGYNAVHYSAAYGHRLCLQLIASE---- 527
Query: 239 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL 298
TPL V + T+M+ D+ R ++PLH AA GH Q +E+L+
Sbjct: 528 --------TPLDVLMETSGTDMLS---------DSDNRATISPLHLAAYHGHHQALEVLV 570
Query: 299 ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL---TALHVAAHCG 355
+ L R +G +PL +AA HVECV L+ A + + DY+ T +H AA G
Sbjct: 571 QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI--LVKDYILKRTPIHAAATNG 628
Query: 356 HYRVTKLLLDKRANPNARAL---NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 412
H +LL+ NA + NG TPL ++ + L+ GA++ A + G T
Sbjct: 629 HSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRT 688
Query: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 472
+H A GH V LLQ+GA + + RG T +H++A G + V+ LL++ A +DA
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748
Query: 473 A----REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
T LH A G V+LLL+ N ++PLH + A +L
Sbjct: 749 PATADNHGYTALHWACYNGHETCVELLLEQEVF-QKTEGNAFSPLHCAVINDNEGAAEML 807
Query: 529 LEA-GAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586
++ GA+ AT KG TPLH AA ++ +LLL A +S G TPL +AA +
Sbjct: 808 IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE-N 866
Query: 587 NQKVALLLLEKGASPHATAKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-- 642
Q + +L AS T ++ T LH+A K A +L + N++
Sbjct: 867 GQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL 926
Query: 643 -TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
TPLH+A++ G T +V LL KGA++ ++G T LA +K +VAD L
Sbjct: 927 QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA-LACAPNK-DVADCL 976
Score = 187 bits (474), Expect = 1e-46
Identities = 124/370 (33%), Positives = 184/370 (49%), Gaps = 1/370 (0%)
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
A F G + V L+ + + T LH AA G E++ L+ +GA V+A+ +
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
TPLH A E VQ+LL+H A +A N TPLHI+A V A L+ + +
Sbjct: 75 LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
++ + G T LH AA G ++ KLLL R A ++ K +H AA+ + +V LL+
Sbjct: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
Query: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
GA K YTPLH AA + + LL+ G + N G TPLH+A G +
Sbjct: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
Query: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVAC 715
V L+D GA ++ + G T LH AA + ++L +GAD + +K G TPL +
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
Query: 716 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 775
+G +++ GA ++ + KNG TPLH AA+ GH +IN L+ GA +G
Sbjct: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374
Query: 776 ALAIAKRLGY 785
L +A G+
Sbjct: 375 PLHLAALSGF 384
Score = 169 bits (429), Expect = 2e-41
Identities = 113/353 (32%), Positives = 178/353 (50%), Gaps = 1/353 (0%)
Query: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500
+R + +L A G + VR L+ V+ + E++TPLH A+ LG EI++LL+ A
Sbjct: 6 LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 501 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 560
+A + TPLH + + VLL+ A + K TPLH+AA ++ A+
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 561 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 620
L+ + + + + G T LH AA + ++ LLL +GA+ +A K +H AA
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 621 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680
+++ L+++GAE K+ TPLH A+ G +V LLD G +++ G T LH+
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPL-IVACHYGNVKMVNFLLKQGANVNAKTKN 739
A + V + L GA + + G+TPL A + L+ GA+VN K+K+
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
G TPLH A G ++Q GA + NGNT L IA R G+ +++TL
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Score = 89.7 bits (221), Expect = 2e-17
Identities = 57/168 (33%), Positives = 78/168 (46%)
Query: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
+ N + TPLH A+ G +++ LL+ GA ++ LT LH A +
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
Query: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
L KH AD +A K TPL +A VK L+ +NVN + G T LH AA GH
Sbjct: 93 LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
Query: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800
++ +LL GA NA A+ A +G+I VV L EVT
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 314 bits (805), Expect = 4e-85
Identities = 266/829 (32%), Positives = 389/829 (46%), Gaps = 89/829 (10%)
Query: 44 LNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN 103
+ L AA GHV +V+ LL + V++ + GNTAL A G +VVKVL++ GA+I
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 104 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGFTPLAVALQQGHNQAVAILL 162
++NG TPL A H++V + LLENGA +T + E + L +A +GH + V LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 163 ENDTKGKVRLPALHIA---ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 219
E + + +H A A D A LL + S VN +S +PL +A
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLL-------LDSGAQVNMPADSFESPLTLA 474
Query: 220 AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG- 278
A G+V +A LL+ RGA+++ G TPL A++ G+ MV LLL +G I+A+T +
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534
Query: 279 ------------------------------LTPLHCAARSGHDQVVELLLERGAPLLART 308
TPL AA+ GH ++V+ LL GA + A T
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
G + L A + H + LLQ A ++ + T L AA GH + L+ K A
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
Query: 369 NPN-ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
N N A N T L +AC + V+ELL+ +GA + G T + AA GH ++V
Sbjct: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 428 LLLQ------NGASPDVTNIRGETALHMAARAGQVEV--------------------VRC 461
LL + PDVT + + H RA +V V
Sbjct: 715 YLLDYPNNLLSAPPPDVTQLTPPS--HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
Query: 462 LLRNGALVDARAREEQTPLH-IASRLGKTEI----------VQLLLQHMAHPDAAT-TNG 509
+RN A+ + TP H IA+ + + + L + DA T +N
Sbjct: 773 PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832
Query: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
T L ++ G ++ LLE GA+ KKGFTPL +AA G + V ++LL A +
Sbjct: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892
Query: 570 SAGKNGL-TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ + TPL +A Q+V LLL +GA+ + YTPL +AA + I LL
Sbjct: 893 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952
Query: 629 NYGAETNIVT--KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQED 685
N GAE N T K G++PL LA+ GHT V LLLD G++I+ ++ T+L LA +
Sbjct: 953 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
Query: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK--TKNGYTP 743
+ V +L A+ + K G TPL+ A G ++ LL +GA+VNA + T
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
Query: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
L AA +GH +L+ GA + GNT L +A G++ VV L
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Score = 308 bits (789), Expect = 3e-83
Identities = 263/826 (31%), Positives = 393/826 (47%), Gaps = 58/826 (7%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M +S +NA S A G+++ V + L G +N + G + L LA G
Sbjct: 219 LTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAG 278
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L A+ G ++VK+L+ A++NAQS G T L
Sbjct: 279 YYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTAL 338
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KG 168
A ++DVVK LLE+GA+ E+G TPL A GH + +LLEN
Sbjct: 339 TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K + LL + AD + K T+ T L A G+V VA
Sbjct: 399 EFKESALTLACYKGHLEMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 450
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 451 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G +E L++ A D+ L T
Sbjct: 511 GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTP 567
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
L AA GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNG 466
E G TP+ AA GH+ V L+ GA+ + T + T L +A G + VV LL +G
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQV 522
A R ++ T L A++ G T +V LL + ++ P T P H R +V
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Query: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH-V 581
V ++ + P K + L ++ +A + A TP H +
Sbjct: 748 PVQALPM-------------VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSI 794
Query: 582 AAHYDNQKV----------ALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNY 630
AA + A+L + A T N T L +A ++ TLL
Sbjct: 795 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 854
Query: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNV 689
GA K+G TPL LA+ GH +V +LLD GA+I S ++ T L LA + V
Sbjct: 855 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 914
Query: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT--KNGYTPLHQA 747
++L GA+++ YTPL +A G V ++ LL GA +N++T K G +PL A
Sbjct: 915 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 974
Query: 748 AQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISVVDTL 792
A GHT + +LL G+ NA N NTAL +A G VV L
Sbjct: 975 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Score = 300 bits (769), Expect = 7e-81
Identities = 294/1043 (28%), Positives = 472/1043 (45%), Gaps = 113/1043 (10%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 67
+ + + A AG+++ L+ G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
Query: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
Query: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187
L+E GA+ ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA---------NINAQTEETQET 536
Query: 188 ALLL--------------------------------QNDHNADVQSKMM----VNRTTES 211
AL L Q H V+ + V+ TT +
Sbjct: 537 ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596
Query: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
G T L A G+ +VA +LL GA ++ + G TPL A++ G+ V+ L+ +G +
Sbjct: 597 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
Query: 272 DAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
+ T + T L A GH VVELLL GA R K+G + L AA+G H V +L
Sbjct: 657 NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Query: 331 LQH-----KAPVDDVTL------DYLTALHVAAHC--------------GHYRVTKLLLD 365
L + AP DVT D A V + T + +
Sbjct: 717 LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRN 776
Query: 366 KRANPNARALNGFTPLH-IACKKNR---------IKVMELLVKYGA-SIQAITESGL-TP 413
K + A A++ TP H IA ++ I +L Y A I A TES T
Sbjct: 777 KAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTA 835
Query: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
+ +A GH +V LL+ GAS + + +G T L +AA AG V VV LL NGA ++A++
Sbjct: 836 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895
Query: 474 -REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
R + TPL +A G+ E+V+LLL A+ + + YTPL ++A G V++ +LL AG
Sbjct: 896 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955
Query: 533 AAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQK 589
A + T K G +PL +AA G KLLL + ++ + N T L +A +
Sbjct: 956 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015
Query: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI--VTKQGVTPLHL 647
V LLL++ A+ AK G TPL AA ++ LL+ GA+ N V T L +
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075
Query: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
A+ +GH LL+ +GA+I + K G T L LAA ++V +L + GAD DA
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 708 YTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
TPL+ A G+VK+V +L+K+ +++ + H+ +
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKD 1195
Query: 766 PNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH------KLNVPETMT 819
A AN N ++ + + +D K+ E EK K
Sbjct: 1196 RQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKL 1248
Query: 820 EVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYLRYSLEGG---RS 875
E ++ ++E + E L+ ED E L + ++ G++ +L G R+
Sbjct: 1249 EEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRN 1308
Query: 876 DSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDN 935
+++ + SS R + + + + DD + I Q + E++ +S S + DN
Sbjct: 1309 NTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS---DN 1365
Query: 936 VALSSSPIHSGRASPCLERDNSS 958
+ +SS S ++ + DN S
Sbjct: 1366 MRISSCSDESSNSNSSRKSDNHS 1388
Score = 199 bits (506), Expect = 2e-50
Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)
Query: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
KA D L LT+ + C L RA A A + L AC + +
Sbjct: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
Query: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 451
+ L+ G S+ TE G + + +A G+ + +LL A+ + I+G+ T L AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511
G V++V+ LL + A V+A++ T L A G ++V++LL+ A + NG+T
Sbjct: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
Query: 512 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
PL + G V+VA +LLE GA HS K+ + L +A G L++ + LL+ A
Sbjct: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
Query: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ T L A + +VA LLL+ GA + A + +PL +AA +++A+ L+
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
Query: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 687
GA V +G TPL A++EGH +MV LLL +GANI+ T+ T+L LA +
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
VAD L K GAD + TPL+ A G++++V +LL GANV+A T G T L A
Sbjct: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Query: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 807
+ GHT + +VLLQ GA + G T L A R G++ V L +++ TT
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
Query: 808 EKH 810
H
Sbjct: 663 NDH 665
Score = 163 bits (412), Expect = 2e-39
Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)
Query: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+S+ + + A G+ + V L+ G I ++ G L LAA GHVG+V+ LL G
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
Query: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+ +++ +++ +T L +A G+ EVV++L+ GAN ++ + +TPL +AA +++++
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
+ T+ +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Query: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+ + T L +A+ +G+ +LL+ RG ID + + G TPL AA GH VV+L
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1174
Score = 32.0 bits (71), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
++ N AA G+LD V ++ G D++ + + L A ++GHV +V+ L+
Sbjct: 1097 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 308 bits (788), Expect = 4e-83
Identities = 233/780 (29%), Positives = 363/780 (46%), Gaps = 51/780 (6%)
Query: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
VN+ +G T L AA+ G+++V LL++RGA ++ +G TPL +A+++G+T +V L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
+ G I+ +DG T L AA GH +VV LL G + + + L AA G H
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
Query: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
+ V +LLQH A V+ + TAL AA+ GH + + LLD A N ++G T L +A
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Query: 385 C-----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439
K V+ LL+ GA + + G+TP+ VAA+ GH+++V LLL+ GA D T
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
Query: 440 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
+ G T L AA G VV LL GA VD+ E +T L IAS G E+V+ LL
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 500 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559
+ G+TPLH++A EG + L+E GA + G P +A++ G D +
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 560 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619
+LL+ ++ D G +G L VAA ++ + LL GA + +G L+I A +N
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 620 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 679
Q+ +A L GA +G T LH++ +GH +MV +L+ A+++ + ++L
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 680 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 739
AA + V V +L +HGA D G T L +A G++ +V LL+ GA+ N +
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
Query: 740 GYTPLHQAAQQGHTHIINVLLQHGAKP-NATTANGNTALAIAKRLGYISVVDTLKVVTEE 798
G T + AA+ GH+ II +L ++GA N + + + S V +L + +
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137
Query: 799 VTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQ 858
+T + +P T E D T+ L ++SL SS
Sbjct: 1138 SGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTV---------DRQKSSLSNNSLKSS- 1187
Query: 859 FLDGMNYLRYSLEGGRSDSLRSFSS---------DRSHTLSHASYLRDSAV----MDDSV 905
++ SLR+ SS D H LS ++ ++ S+
Sbjct: 1188 ---------------KNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSI 1232
Query: 906 VIPSHQVSTLAKEAERNSYRLSWG-------TENLDNVALSSSPIHSGRASPCLERDNSS 958
V PS +L + S W + S + SG A ++ NSS
Sbjct: 1233 VSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSS 1292
Score = 291 bits (746), Expect = 3e-78
Identities = 211/693 (30%), Positives = 338/693 (48%), Gaps = 50/693 (7%)
Query: 88 QAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147
+ EV+++LVK GA++N++ + A + D ++ LL+NGA+ + +G T LA
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 148 VALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 207
A G V +L+ ++ A L +++ H
Sbjct: 551 NAAYSGSLDVVNLLV---------------------SRGADLEIEDAH------------ 577
Query: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
G TPL +AA G+ V L+ GA ++ T ++G T L A+ G+T +V LL
Sbjct: 578 ----GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Query: 268 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327
G ++D D T L AA GH+ +V LL+ GA + G + L AA H E V
Sbjct: 634 GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693
Query: 328 KHLLQHKAPVDDVTLDYLTALHVAAHC-----GHYRVTKLLLDKRANPNARALNGFTPLH 382
+HLL H A V+ +D TAL VAA C GH V LL+D+ A + +G TPL
Sbjct: 694 EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL 753
Query: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442
+A + + V++LL++ GA + +G TP+ AA MGH ++V LL GA+ D +
Sbjct: 754 VAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 813
Query: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
G T L +A+ G VEVVR LL G + R TPLH+A+ G I + L++ A
Sbjct: 814 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Query: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
+ +G P ++++EG D +LLE + G L VAA G D+ +LL
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622
A + +G L++ A + +A LE GA+ A+ G T LH++ + M+
Sbjct: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHME 993
Query: 623 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 682
+ L+ Y A+ N + + L A+ +GH +V LL++ GA + + G T+L +AA
Sbjct: 994 MVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAA 1053
Query: 683 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY- 741
QE ++V +L +HGAD + + G T + VA G+ +++ L K GA+ + NG
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS----SLNGCS 1109
Query: 742 -TPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
+P+H Q+ + + + K N++ + G
Sbjct: 1110 PSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
Score = 282 bits (721), Expect = 2e-75
Identities = 195/587 (33%), Positives = 303/587 (51%), Gaps = 21/587 (3%)
Query: 5 LQKSDSNASFL--RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL 62
+ + DSN L AA +G+LD V + G D+ + +G L LAA++GH +V L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 63 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122
+G G++++ + G TAL A+ G EVV L+ G ++ + T L AA H
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
Query: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRL--P 173
D+V LL++GA + A +G T L A GH + V LL++ D G+ L
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Query: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
AL + A K +LL+ D A+ V+ + G TPL +AA+ G+V+V LLL
Sbjct: 718 ALCVPASKGHASVVSLLI--DRGAE------VDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293
GA VD T NG TPL A+ G+ ++V LL G +D+ +G T L A+ G+ +V
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
Query: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353
V LL+RG R G +PLHMAA H + L++ A +++ D +A+
Sbjct: 830 VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
Query: 354 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 413
GHY ++LL+ ++N + R +G L +A + ++ELL +GA + G
Sbjct: 890 EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
Query: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
+++ A L + L+NGA+ + ++ G TALH++ G +E+V+ L+ A V+A
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Query: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
E+++ L A+ G ++VQLL++H A D G T L I+A+EG +DV VLLE GA
Sbjct: 1010 NEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGA 1069
Query: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
+ A + G T + VAAK G + KLL + A S +P+H
Sbjct: 1070 DPNHADQFGRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVH 1114
Score = 270 bits (689), Expect = 1e-71
Identities = 208/715 (29%), Positives = 328/715 (45%), Gaps = 42/715 (5%)
Query: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290
LL+ GA+V+ NG T L A+ G+ ++V LL+ RG ++ + G TPL AAR GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350
+VV L+ GA + ++G + L AA G H E V LL VD D TAL
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
AA GH + LN L+++GA + G
Sbjct: 651 AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677
Query: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA-----ARAGQVEVVRCLLRN 465
T + AA+MGH IV LL +GA + ++ G TAL +A A G VV L+
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
GA VD ++ TPL +A+ G ++V LLL+ A D NG TPL +A G V
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
Query: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
+ LL GAA +G T L +A+ G+++V + LL R + G TPLH+AA
Sbjct: 798 NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857
Query: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
++ + L+E+GA + +G P +A+++ LL + + G L
Sbjct: 858 GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917
Query: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705
+A+ EGH D+V LL GA+++ G +L++ A E+++ +A+ ++GA+ +A
Sbjct: 918 RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977
Query: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
G T L V+C G+++MV L+ A+VNA + L AA QGH ++ +L++HGA
Sbjct: 978 EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
Query: 766 PNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVS 825
+ T G TAL IA + G+I VV L + ++ ++++ +
Sbjct: 1038 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Query: 826 DEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDR 885
++ G ++ G + + K L S N + G SLR +
Sbjct: 1098 EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGP 1157
Query: 886 SHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSS 940
+H S S DS V + ++ + K ++ +S R + T V + S
Sbjct: 1158 THAFSSPSESPDSTVDRQKSSLSNNSL----KSSKNSSLRTTSSTATAQTVPIDS 1208
Score = 191 bits (486), Expect = 4e-48
Identities = 140/404 (34%), Positives = 201/404 (49%), Gaps = 22/404 (5%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
D L AA G++D V L+GG D++ + NG L AA GH +V LL G++
Sbjct: 747 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
VDS +G T L IAS G EVV+ L+ G + N + G+TPL+MAA E H + + L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDT 184
+E GA + DG P +A Q+GH V ILLEN D +G AL +AA +
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
Query: 185 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 244
LL H ADV K R T L+I A + +A L GA V+ +
Sbjct: 927 DIVELLF--SHGADVNCKDADGRPT------LYILALENQLTMAEYFLENGANVEASDAE 978
Query: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
G T LHV+ +G+ MV++L+ ++A + + L AA GH +VV+LL+E GA +
Sbjct: 979 GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
Query: 305 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 364
G + L +AAQ H++ V+ LL+H A + TA+ VAA GH ++ KLL
Sbjct: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL- 1097
Query: 365 DKRANPNARALNGFTPLHIACKKNR------IKVMELLVKYGAS 402
A +LNG +P + + + KV L +K +S
Sbjct: 1098 ---EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
Score = 107 bits (268), Expect = 8e-23
Identities = 81/242 (33%), Positives = 116/242 (47%), Gaps = 7/242 (2%)
Query: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615
+V +LL++ A +S ++ T V + + LL+ GAS + NG T L A
Sbjct: 495 EVLQLLVKAGAHVNS--EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675
A + + + L++ GA+ I G TPL LA+++GHT +V L+ GANI+ + + G
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
Query: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735
T+L AA V L G D T L A G+ +V LL+ GA VN
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
Query: 736 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA-----KRLGYISVVD 790
G T L AA GH I+ LL HGA+ N +G TAL++A G+ SVV
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
Query: 791 TL 792
L
Sbjct: 733 LL 734
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 306 bits (785), Expect = 9e-83
Identities = 248/777 (31%), Positives = 361/777 (46%), Gaps = 97/777 (12%)
Query: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
L A R G++ +V + L ++N + G + LH AA G +V+ LL G++V +
Sbjct: 187 LEACRNGDVSRV-KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
Query: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
G LH A G AEVV +L+ +GA+ NA+ +TPL+ AA + IDV LL++G
Sbjct: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
A+ + DG + AL A A+L G+ + L AAR + + LL
Sbjct: 306 ADPNIRNTDGKS----ALDLADPSAKAVL-----TGEYKKDELLEAARSGNEEKLMALL- 355
Query: 193 NDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250
+ + VN G TPLH+AA Y V + LLL GA V + G+ PLH
Sbjct: 356 --------TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407
Query: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
A G+ + +LLL G ++A TPLH AA +V LLL GA +
Sbjct: 408 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCH 467
Query: 311 GLSPLHMAAQGDHVECVKH------LLQHKAPVD------DVTLDYL---------TALH 349
G S + MA + E + + LLQ D + L+ + TALH
Sbjct: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
Query: 350 VAA---HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
A H +VT+LLL K AN N + + TPLH+A ++ VME+L K+GA + A+
Sbjct: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL 587
Query: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM----------------- 449
G T +H AA GHL LLL G+ P + +++G TA M
Sbjct: 588 DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRT 647
Query: 450 ---------AARAGQVEVVR--CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
A++AG +E V+ C +N D R TPLH A+ + +V+ LL H
Sbjct: 648 SDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGR-HSTPLHFAAGYNRVSVVEYLLHH 706
Query: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
A A G PLH + G +VA +L+ GA+ ++A FTPLH AA G ++
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC 766
Query: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDN----------------QKVALLLLEKGASP- 601
KLLL+ A ++G TPL + D +K L ++K +P
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE 826
Query: 602 ----HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 657
T TPLH+AA N +++A LL +GA+ N K G+ PLH A+ GH D+
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 658 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
LL+ ++ + K T LH AAQ+ + + +L HGAD + G TPL +A
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 236 bits (601), Expect = 2e-61
Identities = 213/709 (30%), Positives = 303/709 (42%), Gaps = 111/709 (15%)
Query: 165 DTKGKVRLPALHIAA---RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
D G+ P LH AA RKD + + N H D + G PLH A
Sbjct: 211 DMAGRKSSP-LHFAAGFGRKDVVEHLLQMGANVHARD-----------DGGLIPLHNACS 258
Query: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
+G+ V +LLL +GA + TPLH A+ +G ++ +LL G + + DG +
Sbjct: 259 FGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSA 318
Query: 282 LHCA--------------------ARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQ 320
L A ARSG+++ ++ LL A +PLH+AA
Sbjct: 319 LDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAG 378
Query: 321 GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTP 380
+ V V+ LLQH A V L LH A GHY VT+LLL A NA L FTP
Sbjct: 379 YNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTP 438
Query: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA-----------FMGHLNIVLLL 429
LH A KNR++V LL+ +GA + G + + +A F GH L
Sbjct: 439 LHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS-----L 493
Query: 430 LQNGASPDVTNIRG---------------ETALHMAARA---GQVEVVRCLLRNGALVDA 471
LQ D+ ++ ETALH A + + +V LLR GA V+
Sbjct: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553
Query: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531
+ ++ TPLH+A+ +++++L +H A +A T G T LH +A G + +LL
Sbjct: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613
Query: 532 GAAHSLATKKGFTPLHV--------------------------AAKYGSLDVAKLLL--Q 563
G+ S+ + +GFT + A+K G L+ K L Q
Sbjct: 614 GSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673
Query: 564 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623
D G++ TPLH AA Y+ V LL GA HA K G PLH A ++
Sbjct: 674 NVNCRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEV 732
Query: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
A L+ +GA N+ TPLH A+ +G ++ LLL GA+ + G T L L +
Sbjct: 733 AELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE 792
Query: 684 EDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
D ++ D+L A DA K + C N+ N QG N TP
Sbjct: 793 GD-TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI---NCRDTQGRNS--------TP 840
Query: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
LH AA + + LL+HGA NA G L A G++ + L
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
Score = 235 bits (600), Expect = 3e-61
Identities = 196/648 (30%), Positives = 295/648 (45%), Gaps = 86/648 (13%)
Query: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
L AAR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 340 LEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
Query: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
K G LH A G EV ++L+K GA +NA FTPL+ AA +N ++V LL +G
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
A+ + G + A+ + L + KG L A A K+ AL +
Sbjct: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
Query: 193 NDHNADVQSKMMVNRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPL 249
N + +S T LH A H V LLL +GA V+ ++ +TPL
Sbjct: 515 NF------------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
Query: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
HVA++R + +++++L G +++A G T LH AA +GH Q LLL G+ +
Sbjct: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
Query: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
G + M E V+ +L P+ +DY L A+ G K L + N
Sbjct: 623 QGFTAAQMGN-----EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-N 674
Query: 370 PNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
N R L G TPLH A NR+ V+E L+ +GA + A + GL P+H A GH +
Sbjct: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAE 734
Query: 428 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA-------------------- 467
LL+++GAS +V ++ T LH AA G+ E+ + LL++GA
Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD 794
Query: 468 ------------LVDARAR----------------------EEQTPLHIASRLGKTEIVQ 493
L+DA + TPLH+A+ E+ +
Sbjct: 795 TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854
Query: 494 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 553
LL+H A +A G PLH +A G VD+A++L++ + K FTPLH AA+ G
Sbjct: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914
Query: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601
+ LLL A + G TPL +A D + + + + A P
Sbjct: 915 RTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALP 962
Score = 234 bits (597), Expect = 6e-61
Identities = 195/613 (31%), Positives = 281/613 (45%), Gaps = 75/613 (12%)
Query: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
A D R +PLH A+ G ++V+ LL G + A+ GL PLH A GH +VV L
Sbjct: 209 AKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSL 267
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA----- 351
LL +GA AR +PLH AA ++ LLQH A + D +AL +A
Sbjct: 268 LLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 352 -AHCGHYRVTKLLLDKRA-------------NPNARALNG--FTPLHIACKKNRIKVMEL 395
G Y+ +LL R+ N N A +G TPLH+A NR+++++L
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQL 387
Query: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455
L+++GA + A + GL P+H A GH + LLL++GA + ++ T LH AA +
Sbjct: 388 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 447
Query: 456 VEVVRCLLRNGA---LVDARAREE----QTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 508
VEV LL +GA LV+ + TP + RL LLQ D A
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTP-ELRERLTYEFKGHSLLQAAREADLAKVK 506
Query: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
L I + + +H A LH K V +LLL++ A
Sbjct: 507 KTLALEI-----------INFKQPQSHETALHCAVASLHPKRK----QVTELLLRKGANV 551
Query: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ K+ +TPLHVAA + V +L + GA +A G T LH AA +Q LL
Sbjct: 552 NEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL 611
Query: 629 NYGAETNIVTKQGVTPLHL--------------------------ASQEGHTDMVTLLLD 662
+YG++ +I++ QG T + AS+ G + V L
Sbjct: 612 SYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS 671
Query: 663 KGANIHMSTKSGL--TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
N++ G T LH AA ++V+V + L HGAD A K G PL AC YG+
Sbjct: 672 S-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHY 730
Query: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
++ L++ GA+VN +TPLH+AA +G I +LL+HGA P +GNT L +
Sbjct: 731 EVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV 790
Query: 781 KRLGYISVVDTLK 793
K G + D L+
Sbjct: 791 KE-GDTDIQDLLR 802
Score = 155 bits (392), Expect = 3e-37
Identities = 102/288 (35%), Positives = 146/288 (50%), Gaps = 24/288 (8%)
Query: 516 SAREGQVDVASVLLEAGA--AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573
+ R G V L++A A +A +K +PLH AA +G DV + LLQ A +
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633
GL PLH A + + +V LLL +GA P+A YTPLH AA K ++ + LL +GA+
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
Query: 634 TNIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTK 672
NI G + L LA ++ G+ + ++ LL N H S
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367
Query: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
T LHLAA ++V + +L +HGAD A K G PL AC YG+ ++ LLK GA
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
VNA +TPLH+AA + + ++LL HGA P +G +A+ +A
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 142 bits (358), Expect = 3e-33
Identities = 102/323 (31%), Positives = 163/323 (50%), Gaps = 19/323 (5%)
Query: 2 TTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLV 59
+T ++ SD + L A++AG+L+ V+ L ++N + G ++ LH AA V +V
Sbjct: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
Query: 60 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 119
+ LL G+ V + K G LH A G EV ++LV+ GA++N FTPL+ AA +
Sbjct: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
Query: 120 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 179
++ K LL++GA+ + DG TPL + +++G + D + +R A + A
Sbjct: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEG---------DTDIQDLLRGDAALLDA 810
Query: 180 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239
K + L N + + T TPLH+AA Y N+ VA LL GA V+
Sbjct: 811 AKKGCLARVQKLCTPENINCRD------TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
Query: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
+ G+ PLH A+ G+ ++ LL+ ++A + TPLH AA+ G Q+ LLL
Sbjct: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
Query: 300 RGAPLLARTKNGLSPLHMAAQGD 322
GA + + G +PL +A D
Sbjct: 925 HGADPTMKNQEGQTPLDLATADD 947
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 305 bits (782), Expect = 2e-82
Identities = 254/850 (29%), Positives = 376/850 (44%), Gaps = 70/850 (8%)
Query: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
RA + + + V +K D+N ++N LH+AA V + ++ SSV+ + +
Sbjct: 55 RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114
Query: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
G TALH A+L G E+V +L+ +GANINA + L+ AA H+DVV L+ +GA
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 136 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 191
+ + G+TPL A G V LL E D ALHIA L+
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
Query: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 250
D+ A+ VN+ +GFTPLH AA + + LL+N GA V+ +++G +PLH
Sbjct: 235 --DYGAN------VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Query: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
+ + G + L+ GG+ID +DG TPLH AAR GH+ ++ L GA +
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346
Query: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
+ PLH+AA H +C + LL +D T LH AA G+ KLL A+
Sbjct: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406
Query: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA---------FMG 421
+ + G TPLH A +E LV GA++ + G T +H AA +G
Sbjct: 407 HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466
Query: 422 HLN-------------------IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
+ + + LLQN A+P + + G ++H AA G + + L
Sbjct: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
Query: 463 LR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
L N ++ + ++PLH+A+ G + +++LLQ + D G T L ++A +G
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
Query: 521 QVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKN 574
+ L+ GA+ TK+ TPLH + G +LLL+ A D
Sbjct: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
Query: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
G TPL +A Y + LLLEK A+ G T LH + LL
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
Query: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVAD 691
+G TPLH A+ GH ++ LL + G T LH A N +
Sbjct: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
Query: 692 ILTKHGADQDAHTKL---GYTPLIVAC--HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 746
+L +Q K +TPL A +GN + + V+ + G TPL
Sbjct: 765 VL----LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
Query: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTI 806
AA H + +LL+H A NA +G TAL +A G VD L V + +
Sbjct: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL------VNSAQADL 874
Query: 807 TEKHK-LNVP 815
T K K LN P
Sbjct: 875 TVKDKDLNTP 884
Score = 294 bits (752), Expect = 6e-79
Identities = 234/777 (30%), Positives = 344/777 (44%), Gaps = 79/777 (10%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
AA G+LD V + G ++ ++ G LH AA G + +V+ LL G +D G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLENGANQ 135
NTALHIA GQ VV L+ GAN+N + NGFTPL+ AA H + ++ L+ NGA+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195
+ ++DG +PL + A+H + T L+QN
Sbjct: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305
Query: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255
D K G TPLH+AA YG+ + L GA + + PLH+A+
Sbjct: 306 EIDCVDK--------DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357
Query: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315
+++ + LL G +ID + G T LH AA G+ + ++LL GA + K G +PL
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Query: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR----------------- 358
H AA H C++ L+ A V++ TALH AA R
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
Query: 359 -----------VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
+ LL ANP+ R G+ +H A + +ELL++ S +
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
Query: 408 ESGLT--PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
+SG T P+H+AA+ GH + +LLQ+ D+ + +G TAL +AA G E V L+
Sbjct: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
Query: 466 GALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAA---TTNGYTPLHISAREGQ 521
GA + + ++TPLH + G T ++LLL+ +P+A G TPL ++ G
Sbjct: 598 GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657
Query: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
+D S+LLE A G T LH G + ++LL++ + G TPLH
Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
Query: 582 AAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 638
AA + LL+ S GYTPLH A LL +
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777
Query: 639 KQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
TPLH A H + +LLL + + G T L AA D V +L +H
Sbjct: 778 NP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
Query: 697 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGH 752
A +A G T L++A G V+ L+ A++ K K+ TPLH A +GH
Sbjct: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
Score = 254 bits (650), Expect = 4e-67
Identities = 183/577 (31%), Positives = 277/577 (48%), Gaps = 31/577 (5%)
Query: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
TPLHVA+ G+ +++LL+ G +++AK LTPLH A S ++ V++L++ A + A
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366
R KN +PLH+AA V+C + ++ + V+ TALH AA GH + LLL K
Sbjct: 78 RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
Query: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 426
AN NA LH A + V+ LL+ +GA + + G TP+H AA G +N+V
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
Query: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
LL G D N+ G TALH+A GQ VV L+ GA V+ TPLH A+
Sbjct: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257
Query: 487 GKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
+ ++LL+ + A + + +G +PLH++A G+ + L++ G K G TP
Sbjct: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTP 317
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
LHVAA+YG + L A G + + PLH+AA + LL G
Sbjct: 318 LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPD 377
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
K G T LH AA ++ L + GA+ + K G TPLH A+ H + L+ GA
Sbjct: 378 KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
Query: 666 NIHMSTKSGLTSLHLAA----------------------------QEDKVNVADILTKHG 697
N++ + G T+LH AA +++ + L ++
Sbjct: 438 NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497
Query: 698 ADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT--PLHQAAQQGHTHI 755
A+ K GY + A YG+ + + LL++ + ++ +G T PLH AA GH
Sbjct: 498 ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557
Query: 756 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+ VLLQ + G TAL +A G+ V+ L
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
Score = 250 bits (639), Expect = 8e-66
Identities = 200/664 (30%), Positives = 293/664 (44%), Gaps = 44/664 (6%)
Query: 164 NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223
N + R P LH+AA D + LL+ + + + M + TPLH A
Sbjct: 10 NTLDSEKRTP-LHVAAFLGDAEIIELLILSGARVNAKDNMWL--------TPLHRAVASR 60
Query: 224 NVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 283
+ +L+ A V+ +N TPLHVA+ ++++ ++ R G T LH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 284 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 343
AA +GH ++V LLL +GA + A K LH AA H++ V L+ H A V
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 344 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
T LH AA G V K LL+ + + G T LHIAC + V+ L+ YGA++
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 404 QAITESGLTPIHVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
+G TP+H AA H + L LL+ NGA ++ + G++ LHM A G+ + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522
++NG +D ++ TPLH+A+R G ++ L A + PLH++A
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
D LL +G K G T LH AA G+++ KLL A K G TPLH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Query: 583 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA-------------------------- 616
A + L+ GA+ + T G T LH AA
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
Query: 617 --KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
+K LL A +I K+G +H A+ GH + LLL++ + + SG
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
Query: 675 LTS--LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
T LHLAA ++L + D D + G T L +A G+ + V L+ GA+
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 733 VNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNAT---TANGNTALAIAKRLGYISV 788
+ K TPLH + GHT + +LL+ P A A G T L +A G+I
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
Query: 789 VDTL 792
V L
Sbjct: 661 VSLL 664
Score = 239 bits (610), Expect = 2e-62
Identities = 163/528 (30%), Positives = 252/528 (47%), Gaps = 29/528 (5%)
Query: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
+L+ + ++ + TPLH AA G +++ELL+ GA + A+ L+PLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 323 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382
E V+ L++H A V+ ++ T LHVAA + ++++ ++ N G T LH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442
A ++++ LL+ GA+I A + +H AA+MGHL++V LL+ +GA + +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
G T LH AA GQ+ VV+ LL G +D T LHIA G+ +V L+ + A+
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 503 DAATTNGYTPLHISAREGQVDVA-SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
+ NG+TPLH +A + +L+ GA ++ +K G +PLH+ A +G ++ L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
+Q D K+G TPLHVAA Y ++ + L GA + PLH+AA
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681
LL+ G E + K G T LH A+ G+ + + LL GA+ H K G T LH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Query: 682 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH---------YGNVK----------- 721
A + + L GA+ + G T L A GN
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
Query: 722 --------MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
+ FLL+ AN + + K GY +H AA GH + +LL+
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
Score = 206 bits (523), Expect = 2e-52
Identities = 171/602 (28%), Positives = 255/602 (42%), Gaps = 57/602 (9%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
D N AAR G+ + G D C + + LHLAA H ++LL G
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
Query: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
+D+ K G T LH A+ G E +K+L GA+ + + + G TPL+ AA H ++ L
Sbjct: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 129 LENGANQSTATEDGFTPL--AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 186
+ GAN + + G T L A A N+ + L N L K+ T
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTI---LGNAHDNSEELERARELKEKEATLC 489
Query: 187 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 246
LLQND N ++ K G+ +H AA YG+ LLL R + + +G
Sbjct: 490 LEFLLQNDANPSIRDK--------EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 247 T--PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
T PLH+A+ G+ +++LL +D + G T L AA GH + VE L+ GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 305 LARTK-NGLSPLHMAAQGDHVECVKHLLQ---HKAPVDDVTLDYLTALHVAAHCGHYRVT 360
+ +PLH + H C++ LL+ + VD T L +A GH
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
Query: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
LLL+K AN + + G T LH + +++L++ SI G TP+H AA
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Query: 421 GHLNIVLLLLQNGASPD---VTNIRGETALHMAARAGQVEVVRCLLR------------- 464
GH + LLQ S + + +G T LH A G + LL
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT 781
Query: 465 ---------------------NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
+ ++V R + +TPL A+ E +QLLL+H A +
Sbjct: 782 PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
Query: 504 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TPLHVAAKYGSLDVAKLLL 562
A +G T L ++A GQ +L+ + A K TPLH+A G A L+L
Sbjct: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Query: 563 QR 564
+
Sbjct: 902 DK 903
Score = 189 bits (481), Expect = 2e-47
Identities = 116/331 (35%), Positives = 173/331 (52%), Gaps = 3/331 (0%)
Query: 437 DVTNIRGE--TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
DV + E T LH+AA G E++ L+ +GA V+A+ TPLH A E VQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
L++H A +A N TPLH++A V A V++ ++ +++ + G T LH AA G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 614
+++ LLL + A ++ K LH AA+ + V LL+ GA K GYTPLH
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
AA Q+ + LLN G E + + G T LH+A G +V L+D GAN++ +G
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 675 LTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
T LH AA + ++L +GAD + +K G +PL + +G L++ G +
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 764
+ K+G TPLH AA+ GH +IN L GA
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Score = 92.0 bits (227), Expect = 5e-18
Identities = 58/174 (33%), Positives = 84/174 (48%)
Query: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 686
L++ + N + + TPLH+A+ G +++ LL+ GA ++ LT LH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 687 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 746
+L KH AD +A K TPL VA VK ++ ++VN + G T LH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800
AA GH ++N+LL GA NA AL A +G++ VV L EVT
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 296 bits (759), Expect = 1e-79
Identities = 257/815 (31%), Positives = 370/815 (45%), Gaps = 104/815 (12%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSATK 74
A R G++++V + L +N+ + G + LH AA G +V+ LL G++V +
Sbjct: 31 ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
Query: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
G LH A G AEVV +L++ GA+ NA+ +TPL+ AA + IDV LL++GA
Sbjct: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
Query: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ-- 192
+ DG T L +A A A+L K ++ L A ++ K ALL
Sbjct: 150 PTIRNTDGRTALDLA----DPSAKAVLTGEYKKDEL----LESARSGNEEKMMALLTPLN 201
Query: 193 -NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 251
N H +D + TPLH+AA Y V + LLL GA V + + PLH
Sbjct: 202 VNCHASDGRKS-----------TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
Query: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 310
A G+ + +LL+ G ++A TPLH AA +V LLL GA P L N
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
Query: 311 ---------------------GLSPLHMAAQGDHVECVKHL----LQHKAPVDDVTLDYL 345
G S L A + D KHL + K P +
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT-----HE 365
Query: 346 TALHVAAHCGHYR---VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
TALH AA + + + +LLL K AN N + TPLH+A +K V+E++VK+ A
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
Query: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM------------- 449
+ A+ G T +H AA+ GHL LLL G P++ +++G TAL M
Sbjct: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGI 485
Query: 450 -------------AARAGQVEVVR--CLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
AA+AG VE V+ C +++ D R+ TPLH A+ + +V+
Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVEY 544
Query: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
LLQH A A G PLH + G +VA +L++ GA ++A FTPLH AA G
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
Query: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 614
++ KLLLQ A ++G TPL + D LL G L
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLL-------------RGDAALLD 651
Query: 615 AAKKNQMQIASTLLNYGAETNIVTKQG--VTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672
AAKK + L + N QG TPLHLA+ + ++ LL GA+++ K
Sbjct: 652 AAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710
Query: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
GL LH AA V+VA +L K+ A +A K +TPL A G ++ LL GA+
Sbjct: 711 GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 770
Query: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
K + G TPL + + ++ + A P+
Sbjct: 771 PTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805
Score = 278 bits (711), Expect = 4e-74
Identities = 237/745 (31%), Positives = 324/745 (43%), Gaps = 147/745 (19%)
Query: 165 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 224
DT G+ P LH AA LLQN A+VQ++ + G PLH A +G+
Sbjct: 53 DTAGRKSTP-LHFAAGFGRKDVVEYLLQN--GANVQAR------DDGGLIPLHNACSFGH 103
Query: 225 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284
V LLL GA + TPLH A+ +G ++ +LL G + + DG T L
Sbjct: 104 AEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDL 163
Query: 285 A--------------------ARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQGDH 323
A ARSG+++ ++ LL A +PLH+AA +
Sbjct: 164 ADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNR 223
Query: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383
V+ V+ LLQH A V L LH A GHY VT+LL+ A NA L FTPLH
Sbjct: 224 VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHE 283
Query: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA-----------FMGHLNIVLLLLQN 432
A KNR++V LL+ YGA + + I +A F GH LLQ
Sbjct: 284 AASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS-----LLQA 338
Query: 433 GASPDVTNIRG---------------ETALHMAARAG---QVEVVRCLLRNGALVDARAR 474
DVT I+ ETALH AA + + ++ LLR GA ++ + +
Sbjct: 339 AREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398
Query: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL------ 528
E TPLH+AS ++V+++++H A +A G T LH +A G + +L
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCD 458
Query: 529 --------------------------------------LEAGAAHSLATKKGF------- 543
LEA A + T K
Sbjct: 459 PNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVN 518
Query: 544 ---------TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
TPLH AA Y + V + LLQ A + K GL PLH A Y + +VA LL
Sbjct: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578
Query: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
++ GA + +TPLH AA K + +I LL +GA+ + G TPL L ++G T
Sbjct: 579 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDT 637
Query: 655 DMVTLLLDKGANIHMSTKSGL----------------------TSLHLAAQEDKVNVADI 692
D+ LL A + + K L T LHLAA + + VA+
Sbjct: 638 DIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEY 697
Query: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
L +HGAD +A K G PL A YG+V + L+K A VNA K +TPLH+AAQ+G
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757
Query: 753 THIINVLLQHGAKPNATTANGNTAL 777
T + +LL HGA P G T L
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPL 782
Score = 228 bits (582), Expect = 3e-59
Identities = 189/599 (31%), Positives = 266/599 (44%), Gaps = 77/599 (12%)
Query: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
TA TPLH A+ G ++V+ LL G + A+ GL PLH A GH +VV LLL
Sbjct: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
Query: 301 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA------AHC 354
GA AR +PLH AA ++ LLQH A D TAL +A
Sbjct: 114 GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLT 173
Query: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
G Y+ +LL R+ + + TPL++ C A TP+
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTPLNVNC------------------HASDGRKSTPL 215
Query: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 474
H+AA + IV LLLQ+GA + LH A G EV L+++GA V+A
Sbjct: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
Query: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHP-----------DAATT-----------NGYTP 512
+ TPLH A+ + E+ LLL + A P D A T G++
Sbjct: 276 WQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSL 335
Query: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG---SLDVAKLLLQRRAAAD 569
L +ARE V L + + T LH AA + +LLL++ A +
Sbjct: 336 LQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANIN 394
Query: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
K LTPLHVA+ + V ++++ A +A G T LH AA +Q LL+
Sbjct: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
Query: 630 YGAETNIVTKQGVTPLHLASQE-----------GHTDMVTLLLDKGANIHMSTKSGL--- 675
YG + NI++ QG T L + ++ G+++ LL+ + T L
Sbjct: 455 YGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTV 514
Query: 676 -------------TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
T LH AA ++V+V + L +HGAD A K G PL AC YG+ ++
Sbjct: 515 QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEV 574
Query: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
L+K GA VN +TPLH+AA +G I +LLQHGA P +GNT L + K
Sbjct: 575 AELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
Score = 226 bits (577), Expect = 1e-58
Identities = 212/725 (29%), Positives = 314/725 (43%), Gaps = 101/725 (13%)
Query: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
L +AR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 182 LESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
Query: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
K LH A G EV ++LVK GA +NA FTPL+ AA +N ++V LL G
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
A+ + L HN++ L P + R LLQ
Sbjct: 301 ADPT-------------LLNCHNKSAIDLA----------PTPQLKERLAYEFKGHSLLQ 337
Query: 193 NDHNADVQ------SKMMVN-RTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTA 242
ADV S MVN + ++ T LH AA + + LLL +GA ++
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
Query: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 302
+ +TPLHVAS++ + ++V++++ +++A G T LH AA GH Q LLL G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
Query: 303 PLLARTKNGLSPLHM--------------------------AAQGDHVECVKHLLQ-HKA 335
+ G + L M AA+ VE VK L
Sbjct: 458 DPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 336 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 395
D+ T LH AA V + LL A+ +A+ G PLH AC +V EL
Sbjct: 518 NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAEL 577
Query: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455
LVK+GA + TP+H AA G I LLLQ+GA P N G T L + + G
Sbjct: 578 LVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGD 636
Query: 456 VEVVRCLLRNGALVDARAR----------------------EEQTPLHIASRLGKTEIVQ 493
++ L + AL+DA + TPLH+A+ E+ +
Sbjct: 637 TDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696
Query: 494 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 553
LLQH A +A G PLH +A G VDVA++L++ A + K FTPLH AA+ G
Sbjct: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756
Query: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 613
+ LLL A + G TPL + + D V+ LL A P + + Y P
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPLDLVSADD---VSALL--TAAMPPSALPSCYKP-- 809
Query: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
Q+ + + + GA + ++ +P L++ ++ + + + S
Sbjct: 810 --------QVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTE 861
Query: 674 GLTSL 678
G +SL
Sbjct: 862 GASSL 866
Score = 171 bits (433), Expect = 6e-42
Identities = 139/449 (30%), Positives = 203/449 (45%), Gaps = 72/449 (16%)
Query: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501
R T LH AA G+ +VV LL+NGA V AR PLH A G E+V LLL+H A
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGAD 116
Query: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
P+A YTPLH +A +G++DV VLL+ GA ++ G T L +A AK +
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS-----AKAV 171
Query: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
L D L A + +K+ LL + HA+ TPLH+AA N++
Sbjct: 172 LTGEYKKDEL-------LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 224
Query: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681
+I LL +GA+ + K + PLH A GH ++ LL+ GA ++ T LH A
Sbjct: 225 KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284
Query: 682 AQEDKVNVADILTKHGADQ---DAHTK----LGYTP--------------LIVACHYGNV 720
A +++V V +L +GAD + H K L TP L+ A +V
Sbjct: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344
Query: 721 ---------KMVNF---------------------------LLKQGANVNAKTKNGYTPL 744
+MVNF LL++GAN+N KTK TPL
Sbjct: 345 TRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPL 404
Query: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV---TEEVTT 801
H A+++ H ++ V+++H AK NA G T+L A G++ L ++
Sbjct: 405 HVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL 464
Query: 802 TTTTITEKHKLNVPETMTEVLDVSDEEGD 830
T + NV + + E + + + E D
Sbjct: 465 QGFTALQMGNENVQQLLQEGISLGNSEAD 493
Score = 150 bits (378), Expect = 1e-35
Identities = 99/287 (34%), Positives = 140/287 (48%), Gaps = 22/287 (7%)
Query: 516 SAREGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574
+ R G V+ L+ +S T + TPLH AA +G DV + LLQ A +
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
Query: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
GL PLH A + + +V LLL GA P+A YTPLH AA K ++ + LL +GAE
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 635 NIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTKS 673
I G T L LA ++ G+ + M+ LL N H S
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
Query: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
T LHLAA ++V + +L +HGAD A K PL AC YG+ ++ L+K GA V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
Query: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
NA +TPLH+AA + + ++LL +GA P + +A+ +A
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 137 bits (345), Expect = 1e-31
Identities = 98/319 (30%), Positives = 154/319 (48%), Gaps = 17/319 (5%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
L S+++ L AA+AG+++ V + ++ LH AA V +V+ LL
Sbjct: 487 LGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLL 546
Query: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 123
G+ V + K G LH A G EV ++LVK GA +N FTPL+ AA + +
Sbjct: 547 QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYE 606
Query: 124 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 183
+ K LL++GA+ + DG TPL + ++ G + D + +R A + A K
Sbjct: 607 ICKLLLQHGADPTKKNRDGNTPLDL-VKDG---------DTDIQDLLRGDAALLDAAKKG 656
Query: 184 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 243
+ L + N + + T TPLH+AA Y N+ VA LL GA V+ +
Sbjct: 657 CLARVKKLSSPDNVNCRD------TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710
Query: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
G+ PLH A+ G+ ++ LL+ ++A + TPLH AA+ G Q+ LLL GA
Sbjct: 711 GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 770
Query: 304 LLARTKNGLSPLHMAAQGD 322
+ + G +PL + + D
Sbjct: 771 PTLKNQEGQTPLDLVSADD 789
Score = 95.5 bits (236), Expect = 4e-19
Identities = 75/257 (29%), Positives = 104/257 (40%), Gaps = 54/257 (21%)
Query: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
AAA++ + D ++V L+ + + TA TPLH AA + +
Sbjct: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75
Query: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
LL GA G+ PLH A GH ++V LLL GA+ + T LH AA +
Sbjct: 76 YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
Query: 686 KVNVADILTKHGAD-----QDAHTKLG--------------------------------- 707
K++V +L +HGA+ D T L
Sbjct: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195
Query: 708 -YTPLIVACH---------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 751
TPL V CH Y VK+V LL+ GA+V+AK K PLH A G
Sbjct: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
Query: 752 HTHIINVLLQHGAKPNA 768
H + +L++HGA NA
Sbjct: 256 HYEVTELLVKHGACVNA 272
Score = 66.2 bits (160), Expect = 3e-10
Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 15/139 (10%)
Query: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
TPL A +G +V +LL+ GANV A+ G PLH A GH ++N+LL+HGA PNA
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 828
T L A G I V L E T T LD++D
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT------------DGRTALDLADPS 167
Query: 829 GDDTMTGDGGEYLRPEDLK 847
+T GEY + E L+
Sbjct: 168 AKAVLT---GEYKKDELLE 183
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 293 bits (751), Expect = 8e-79
Identities = 262/848 (30%), Positives = 378/848 (44%), Gaps = 86/848 (10%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
A +G+L+ V L G +N C++ LH AA GH+ +++ L+ RG+ + +KG
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
LH A+ +GQ EVVK L++ GA I+ + G T L++A V L+ GAN +
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 137 TATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDTKSAALLL 191
+ GFTPL VA + LL N + + K LH+AA + +L+
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
Query: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI---TP 248
QN D K G TPLH+AA YG+ + + L+ GA TAR GI P
Sbjct: 327 QNGSEIDCADKF--------GNTPLHVAARYGHELLISTLMTNGAD---TARRGIHDMFP 375
Query: 249 LHVASKRGNTNMVKLLLDRG----------------GQIDAKTRD--GLTPLHCAARSGH 290
LH+A G ++ + LL G D T D G T LH AA G+
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
Query: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350
+ + LLL GA L R K G +PLH AA +C L+ A V++ + LH
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
Query: 351 AAHCGHYR----------------------------VTKLLLDKRANPNARALNGFTPLH 382
AA YR + LLD A+P+ R G+T +H
Sbjct: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
Query: 383 IACKKNRIKVMELLVKYGASIQAITESGL--TPIHVAAFMGHLNIVLLLLQNGASPDVTN 440
A + +ELL++ + ES + +P+H+AA+ GH + L + + DV +
Sbjct: 556 YAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
Query: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLL--- 496
+G TAL +A G E V L +GA + R+ + TPLH A+ G T+ + LL+
Sbjct: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
Query: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556
+ D G TPL ++ G VD +LLE G+ A +G T LH A G D
Sbjct: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
Query: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH----ATAKNGYTPL 612
LL A G TP+H+A+ + V LL+ S +GY+P+
Sbjct: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795
Query: 613 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA---SQEGHTDMVTLLLDKGANIHM 669
H A+ LL + + + + TPLH A +Q+ T+M LL GA I
Sbjct: 796 HWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM--LLGALGAKIVN 852
Query: 670 STKS-GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728
S + G T LH AA D V+ +L +H A+ +A G T L+ A G V FLL
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
Query: 729 QG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLL---QHGAKPNATTANGNTALAIAKRLG 784
+G A++ +N T LH A +GH ++L Q NAT + L IA R G
Sbjct: 913 RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
Query: 785 YISVVDTL 792
SVV L
Sbjct: 973 LASVVQAL 980
Score = 283 bits (725), Expect = 8e-76
Identities = 250/840 (29%), Positives = 362/840 (43%), Gaps = 72/840 (8%)
Query: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
RAA + N + L D+N ++ LH+AA + L SS++ A +
Sbjct: 80 RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
G +ALH A +G E V +L+ +GA++N + PL+ AA H++V+K L+ GA+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 136 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 191
G+ L A G + V LL E D ALHIA A L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
Query: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 250
N VN+ + GFTPLH+AA N + LL+N GA V++ ++ G +PLH
Sbjct: 260 NAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311
Query: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
+A+ G ++L+ G +ID + G TPLH AAR GH+ ++ L+ GA R +
Sbjct: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
Query: 311 GLSPLHMAAQGDHVECVKHLLQH----------------KAPVDDVTLDYL--TALHVAA 352
+ PLH+A +C + LL A D T D L T LH AA
Sbjct: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431
Query: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 412
G+ LLL A+ R G TPLH A + LV GA + G +
Sbjct: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
Query: 413 PIHVAAFMGHLN----------------------------IVLLLLQNGASPDVTNIRGE 444
P+H AA + LL NGA P + + +G
Sbjct: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551
Query: 445 TALHMAARAGQVEVVRCLLRN--GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
TA+H AA G + + LL L D + +PLH+A+ G E ++ L + + +
Sbjct: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
Query: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLL 561
D G T L ++ G + VL GA+ + K+ +TPLH AA G D LL
Sbjct: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
Query: 562 L---QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618
+ +R D G TPL +A + LLLEKG++ A G T LH A
Sbjct: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
Query: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK----SG 674
+ LL++ A +G TP+HLAS GHT ++ LL + SG
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791
Query: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGAN- 732
+ +H A+ + ++L +H +TPL A LL GA
Sbjct: 792 YSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKI 850
Query: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
VN++ G TPLH AA + + +LLQH A+ NAT G TAL A G + V+ L
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Score = 269 bits (688), Expect = 2e-71
Identities = 230/786 (29%), Positives = 364/786 (46%), Gaps = 60/786 (7%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
AA +G ++ V L+ G +I+ N G ALH+A G + EL+ G++V+ KG
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 77 NTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
T LH+A+++ + +++LV GA++N QS+ G +PL+MAA + L++NG+
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
Query: 136 STATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAALLL 191
A + G TPL VA + GH ++ L+ N DT +G + LH+A + LL
Sbjct: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
Query: 192 QNDHNADVQSKMMVNRTTESGF----------TPLHIAAHYGNVNVATLLLNRGAAVDFT 241
+ + S + +GF T LH AA GNV LLL+ GA +
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
Query: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS------------G 289
+ G TPLH A+ G+ L+ G ++ G +PLH AA S
Sbjct: 453 DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512
Query: 290 HDQ----------------VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
HD +E LL+ GA R + G + +H AA + + ++ LL+
Sbjct: 513 HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
Query: 334 KAP-VDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 391
++DV ++ LH+AA+ GH K L + N + R G T L +A ++ +
Sbjct: 573 SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632
Query: 392 VMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETAL 447
+E+L +GAS + + TP+H AA GH + + LL+ +G D+T++ G+T L
Sbjct: 633 CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692
Query: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
+A G V+ V LL G+ DA +T LH + G + + LL H A
Sbjct: 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
Query: 508 NGYTPLHISAREGQVDVASVLLEAGAA----HSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
G TP+H+++ G V LL+A + + G++P+H A+ G D +LLL+
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Query: 564 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQM 621
+ G N TPLH A + +LL + +++ G TPLH AA + +
Sbjct: 813 HSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNV 871
Query: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHL 680
LL + AE N G T L A++ G T V LL +G A++ + ++ T+LHL
Sbjct: 872 SGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931
Query: 681 AAQEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 737
A + A ++ D +A PL +A G +V LL GA V A
Sbjct: 932 ACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991
Query: 738 KNGYTP 743
+ G+TP
Sbjct: 992 EEGHTP 997
Score = 246 bits (629), Expect = 1e-64
Identities = 205/698 (29%), Positives = 296/698 (42%), Gaps = 119/698 (17%)
Query: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 258
+ K +N + TPLH AA+ G+V + LLL GA V+ +TPLH A+ N
Sbjct: 28 LSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNE 87
Query: 259 NMVKLLLDRGGQIDAKTRDGLTPLHCAA-------------------------------- 286
++ LLL ++A+ + TPLH AA
Sbjct: 88 KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 147
Query: 287 -RSGHDQVVELLLE---------------------------------RGAPLLARTKNGL 312
SGH + V LLL RGA L + + G
Sbjct: 148 VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGY 207
Query: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
LH AA +E VK+LL+ A +D+ TALH+A + G V L++ AN N
Sbjct: 208 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 373 RALNGFTPLHIAC-KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
GFTPLH+A N +ELLV GA + ++ G +P+H+AA G +L+Q
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 432 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 491
NG+ D + G T LH+AAR G ++ L+ NGA R + PLH+A G ++
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Query: 492 VQLLL--------------QHM--AHPDAATTN--GYTPLHISAREGQVDVASVLLEAGA 533
+ LL +H+ A D T + G T LH +A G V+ ++LL +GA
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA 447
Query: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA-- 591
K G TPLH AA GS A L+ A + A G +PLH AA D + A
Sbjct: 448 DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEP 507
Query: 592 --------------------------LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
LL+ GA P + GYT +H AA Q
Sbjct: 508 HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLE 567
Query: 626 TLL--NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
LL ++ ++ + V+PLHLA+ GH + + L + N+ + G T+L LA +
Sbjct: 568 LLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627
Query: 684 EDKVNVADILTKHGADQ-DAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKN 739
++LT HGA K +TPL A G+ ++ L+ G +
Sbjct: 628 RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY 687
Query: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
G TPL A GH +++LL+ G+ +A G TAL
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Score = 234 bits (597), Expect = 6e-61
Identities = 186/627 (29%), Positives = 281/627 (44%), Gaps = 49/627 (7%)
Query: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274
PL A +V LL++ ++ + TPLH A+ G+ +++LLL G ++AK
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
LTPLH AA S +++V+ LLL A + AR K +PLH+AA +C + L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 335 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 394
+ ++ +ALH A H GH LLL+K A+ N PLH A ++V++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 395 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 454
LLV GA + G +H AA G + +V LL+ GA D N G TALH+A G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Query: 455 QVEVVRCLLRNGALVDARAREEQTPLHIAS-RLGKTEIVQLLLQHMAHPDAATTNGYTPL 513
Q V L+ GA V+ + TPLH+A+ ++LL+ + A + + G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Query: 514 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573
H++A G+ + +L++ G+ A K G TPLHVAA+YG + L+ A G
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
Query: 574 NGLTPLHVAAHYDNQKVALLLLEKG---------ASPHATAKN---------GYTPLHIA 615
+ + PLH+A + LL G ++ H + G T LH A
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
Query: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675
A ++ + LL+ GA+ K G TPLH A+ G L+ GA ++ + G
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
Query: 676 TSLHLAAQEDKVNVA----------------------------DILTKHGADQDAHTKLG 707
+ LH AA D A + L +GAD + G
Sbjct: 491 SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
Query: 708 YTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
YT + A YGN + + LL+ N + ++ +PLH AA GH + L +
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
Query: 766 PNATTANGNTALAIAKRLGYISVVDTL 792
+ G TAL +A G V+ L
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVL 637
Score = 205 bits (521), Expect = 4e-52
Identities = 198/729 (27%), Positives = 310/729 (42%), Gaps = 60/729 (8%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Q + + AA G + ++ G +I+ ++ G LH+AA+ GH L+ L+
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA------------------NINAQSQ 107
G+ LH+A L G ++ + L+ G +IN
Sbjct: 362 GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDN 421
Query: 108 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----- 162
G T L+ AA +++ + LL +GA+ + G TPL A G Q L+
Sbjct: 422 LGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG 481
Query: 163 --ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220
E D KG LH AA D + A + H+A+ + +R E+ F
Sbjct: 482 VNEADCKG---CSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFF------- 531
Query: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI--DAKTRDG 278
LL+ GA R G T +H A+ GN ++LLL+ D ++
Sbjct: 532 ------CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP 585
Query: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PV 337
++PLH AA +GH + ++ L E L R G + L +A + ECV+ L H A +
Sbjct: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 338 DDVTLDYLTALHVAAHCGHYRVTKLLLD--KRAN-PNARALNGFTPLHIACKKNRIKVME 394
T LH AA GH LL+D +RA+ + G TPL +A + +
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
Query: 395 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 454
LL++ G++ A G T +H A G + + LL + A + +G T +H+A+ G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Query: 455 QVEVVRCLLRNGALVDARAR----EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
V+R LL+ D +P+H AS G + ++LLL+H N +
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF-SYLEGNPF 824
Query: 511 TPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
TPLH + Q +LL A A + ++ KG TPLH AA ++ ++LLQ +A
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTL 627
++ G T L AA LL +G A +N T LH+A K + A +
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944
Query: 628 LNYGAETNIVTKQGVT---PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684
L + ++ PLH+A++ G +V LL GA + + G T LA
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAP 1003
Query: 685 DKVNVADIL 693
+K +VAD L
Sbjct: 1004 NK-DVADCL 1011
Score = 197 bits (502), Expect = 6e-50
Identities = 192/673 (28%), Positives = 280/673 (41%), Gaps = 117/673 (17%)
Query: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89
L G DINT + G LH AA G+V + LL G+ + K G T LH A+ G
Sbjct: 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469
Query: 90 EVVKVLVKEGANINAQSQNGFTPLYMAAQ-------ENHID------------------- 123
+ LV GA +N G +PL+ AA E H
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEA 529
Query: 124 --VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE------NDTKGKVRLPAL 175
+++LL+NGA+ S G+T + A G+ Q + +LLE D + + + L
Sbjct: 530 FFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPL 589
Query: 176 HIAARKDDTKSAALLLQNDHNADVQS---KMMVNRTTESG-------------------- 212
H+AA ++ L + N DV+ + + TE G
Sbjct: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
Query: 213 ---FTPLHIAAHYGNVNVATLLLNRGAAVDFTA---RNGITPLHVASKRGNTNMVKLLLD 266
+TPLH AA G+ + LL++ G D T G TPL +A G+ + V LLL+
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709
Query: 267 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
+G DA G T LH A +G + + LL+ A +L R G +P+H+A+ H
Sbjct: 710 KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 769
Query: 327 VKHLLQHKAPVD--DVTLDY--LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382
++ LLQ D D +DY + +H A++ GH +LLL+ N FTPLH
Sbjct: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLH 828
Query: 383 IACKKNRIKVMELLV-KYGASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440
A N+ E+L+ GA I ++ G TP+H AAF +++ + +LLQ+ A + T+
Sbjct: 829 CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATD 888
Query: 441 IRGETALHMAARAGQVEVVRCLLRNG---------------------------------- 466
G TAL AA GQ V LL G
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948
Query: 467 ---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 523
L++A Q PLHIA+R G +VQ LL H A A G+TP A D
Sbjct: 949 QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA--PNKD 1006
Query: 524 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
VA L A L+T K F P + + + + AAA + G G P +
Sbjct: 1007 VADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTVGGCGALPHGASC 1058
Query: 584 HYDNQKVALLLLE 596
Y ++ + L+
Sbjct: 1059 PYSQERPGAIGLD 1071
Score = 166 bits (419), Expect = 3e-40
Identities = 118/356 (33%), Positives = 178/356 (50%), Gaps = 1/356 (0%)
Query: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
+ +I + L A + VE VR LL ++ +E +TPLH A+ +G I+QLLL
Sbjct: 3 ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
Query: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557
A+ +A T TPLH +A V +LL A + K TPLHVAA +
Sbjct: 63 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
Query: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
A+ L ++ + A ++G + LH A H + + LLL KGAS + K PLH AA
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
Query: 618 KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 677
+++ L+ GA+ ++G LH A+ G ++V LL GA I G T+
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
Query: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM-VNFLLKQGANVNAK 736
LH+A + VA L GA+ + G+TPL VA N + + L+ GA+VN +
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
Query: 737 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+K G +PLH AA G +L+Q+G++ + GNT L +A R G+ ++ TL
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Score = 87.4 bits (215), Expect = 1e-16
Identities = 61/190 (32%), Positives = 88/190 (46%)
Query: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669
TPLH AA + I LL GA N +TPLH A+ + ++ LLL A+++
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
Query: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
K T LH+AA A+ L + + + G + L A H G+++ VN LL +
Sbjct: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
Query: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
GA++N K PLH AA GH ++ +L+ GA G L A G I VV
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222
Query: 790 DTLKVVTEEV 799
L + E+
Sbjct: 223 KYLLRMGAEI 232
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 249 bits (637), Expect = 1e-65
Identities = 166/475 (34%), Positives = 267/475 (56%), Gaps = 8/475 (1%)
Query: 319 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG- 377
++GD V V+ LL V++ T + + L +A G+Y + ++LL AN R + G
Sbjct: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
TPL A +K+++LL+ + A + A + +G T + A G++++V +LL++GAS +
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL 496
N G T L A AG VEV R LL NGA ++ + E +++ L +A G E+V+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556
+ A + T +T L + +G V+VA +LL++GA ++ +PL +AA G ++
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIA 615
+A LL++R A+ + G TPL AA ++++ LLL +GA+ +A T + T L +A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675
+++A L+ GA+ + TPL A+QEGH ++V LL GAN+H +T +G
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
Query: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735
T+L A + +VAD+L + GAD + ++ G TPL+ A G+V V FL+ +GANVN
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 736 KT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
T N +T L A GH ++ +LL HGA P +G+T L A + G+ SVV
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Score = 221 bits (564), Expect = 4e-57
Identities = 178/545 (32%), Positives = 271/545 (49%), Gaps = 29/545 (5%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M +S +NA S A G+++ V + L G +N + G + L LA G
Sbjct: 219 LTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAG 278
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L A+ G ++VK+L+ A++NAQS G T L
Sbjct: 279 YYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTAL 338
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KG 168
A ++DVVK LLE+GA+ E+G TPL A GH + +LLEN
Sbjct: 339 TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K + LL + AD + K T+ T L A G+V VA
Sbjct: 399 EFKESALTLACYKGHLEMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 450
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 451 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G +E L++ A D+ L T
Sbjct: 511 GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTP 567
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
L AA GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNG 466
E G TP+ AA GH+ V L+ GA+ + T + T L +A G + VV LL +G
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQV 522
A R ++ T L A++ G T +V LL + ++ P T P H R +V
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Query: 523 DVASV 527
V ++
Sbjct: 748 PVQAL 752
Score = 217 bits (553), Expect = 7e-56
Identities = 169/489 (34%), Positives = 246/489 (50%), Gaps = 13/489 (2%)
Query: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKN 310
A G+ N V+ LL G ++ T +G + L A +G+ ++ ++LL A + R K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
++PL AA G HV+ VK LL HKA V+ + TAL A G+ V K+LL+ A+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426
NG TPL A ++V LL++ GA I ES LT +A + GHL +V
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMV 417
Query: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
Query: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TP 545
G E+ LL++ A + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
L +A G L+VA L++ A + TPL AA + ++ LL GA+ HAT
Sbjct: 538 LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
G T L A + +A LL GA+ ++ G TPL A++ GH V L+ KGA
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
Query: 666 NIHMSTKSG-LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
N++ +T + T L LA + V ++L HGAD K G T LI A G+ +V
Sbjct: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 725 FLLKQGANV 733
+LL N+
Sbjct: 715 YLLDYPNNL 723
Score = 215 bits (547), Expect = 4e-55
Identities = 168/518 (32%), Positives = 259/518 (50%), Gaps = 12/518 (2%)
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM----VNRTTESGFTPLHIAAHYGN 224
++R + A + D+ A + D NA V+ ++ VN TE G + L +A G
Sbjct: 221 RMRAESTANAGQSDNRSLAEACSEGDVNA-VRKLLIEGRSVNEHTEEGESLLCLACSAGY 279
Query: 225 VNVATLLLNRGAAVDFTARNG-ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 283
+A +LL A V+ G ITPL A+ G+ +VKLLL ++A++ G T L
Sbjct: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
Query: 284 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 343
A G+ VV++LLE GA + +NG +PL A HVE + LL++ A ++ + +
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
Query: 344 YL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
+ +AL +A + GH + + LL+ A+ + T L AC ++V LL+ GA
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459
Query: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
+ +S +P+ +AA GH+ + LL++ GAS + N G T L AAR G E+V L
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
Query: 463 LRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 521
L GA ++A+ E Q T L +A G E+ L++ A + + TPL +A+EG
Sbjct: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576
Query: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
+++ LL AGA T G T L A + G DVA +LLQ A + + G TPL
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 582 AAHYDNQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640
AA + L+ KGA+ + TA N +T L +A + + LL +GA+ K
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
Query: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
G T L A++ GHT +V LLD N+ + +T L
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
Score = 199 bits (506), Expect = 2e-50
Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)
Query: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
KA D L LT+ + C L RA A A + L AC + +
Sbjct: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
Query: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 451
+ L+ G S+ TE G + + +A G+ + +LL A+ + I+G+ T L AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511
G V++V+ LL + A V+A++ T L A G ++V++LL+ A + NG+T
Sbjct: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
Query: 512 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
PL + G V+VA +LLE GA HS K+ + L +A G L++ + LL+ A
Sbjct: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
Query: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ T L A + +VA LLL+ GA + A + +PL +AA +++A+ L+
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
Query: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 687
GA V +G TPL A++EGH +MV LLL +GANI+ T+ T+L LA +
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
VAD L K GAD + TPL+ A G++++V +LL GANV+A T G T L A
Sbjct: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Query: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 807
+ GHT + +VLLQ GA + G T L A R G++ V L +++ TT
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
Query: 808 EKH 810
H
Sbjct: 663 NDH 665
Score = 191 bits (486), Expect = 4e-48
Identities = 217/844 (25%), Positives = 354/844 (41%), Gaps = 100/844 (11%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 67
+ + + A AG+++ L+ G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
Query: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
Query: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187
L+E GA+ ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQET 536
Query: 188 ALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTARN 244
AL L + ++ + TPL AA G++ + LL GA V T
Sbjct: 537 ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596
Query: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
G T L A + G+T++ +LL G ++ ++ G TPL AAR+GH V+ L+ +GA +
Sbjct: 597 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
Query: 305 LART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
T N + L +A G H+ V+ LL H A D T L AA GH V L
Sbjct: 657 NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Query: 364 LDKRAN----PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 419
LD N P P H + R+ V L + E P +VA
Sbjct: 717 LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVA-- 769
Query: 420 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479
L ++N A+ + +++ H+ A + V+ ++V+ A+ + T
Sbjct: 770 ------TTLPIRNKAAS-----KQKSSSHLPANSQDVQGYITNQSPESIVE-EAQGKLTE 817
Query: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE--AGAAHSL 537
L + + QL +AH D T L+ RE Q+ +LE L
Sbjct: 818 LEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILEELQKVEREL 876
Query: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL---- 593
K T + +Y + ++ LQ++ LTP+ V A L
Sbjct: 877 QLK---TQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933
Query: 594 -LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE- 651
+L K A+ G+ P+ A + +A+ L G+ N+ QGV + Q
Sbjct: 934 PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQPV 989
Query: 652 -GHTDMVTLLLDKGANIHMSTKSGLTSLH------------LAAQEDKVNVADILTKH-- 696
G + L G I T+ GL +AA + + H
Sbjct: 990 LGQAQLAGL----GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSI 1045
Query: 697 --------------------------GADQDAHTKLGY-TPLIVACHYGNVKMVNFLLKQ 729
D DA T+ + T L +AC G+ ++V LL++
Sbjct: 1046 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 1105
Query: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISV 788
GA++ + K G+TPL AA GH ++ +LL +GA A + +T L++A G V
Sbjct: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165
Query: 789 VDTL 792
V+ L
Sbjct: 1166 VELL 1169
Score = 177 bits (450), Expect = 7e-44
Identities = 165/575 (28%), Positives = 267/575 (46%), Gaps = 29/575 (5%)
Query: 403 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
I A TES T + +A GH +V LL+ GAS + + +G T L +AA AG V VV
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
Query: 462 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
LL NGA ++A++ R + TPL +A G+ E+V+LLL A+ + + YTPL ++A G
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
Query: 521 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577
V++ +LL AGA + T K G +PL +AA G KLLL + ++ + N T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
Query: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 637 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
V T L +A+ +GH LL+ +GA+I + K G T L LAA ++V +L +
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHT 753
GAD DA TPL+ A G+VK+V +L+K+ +++ +
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
Query: 754 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH--- 810
H+ + A AN N ++ + + +D K+ E EK
Sbjct: 1435 HLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEK 1487
Query: 811 ---KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYL 866
K E ++ ++E + E L+ ED E L + ++ G++
Sbjct: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT 1547
Query: 867 RYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS 923
+L G R++++ + SS R + + + + DD + I Q + E++ +S
Sbjct: 1548 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS 1607
Query: 924 YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSS 958
S + DN+ +SS S ++ + DN S
Sbjct: 1608 TSESGDS---DNMRISSCSDESSNSNSSRKSDNHS 1639
Score = 171 bits (433), Expect = 6e-42
Identities = 122/334 (36%), Positives = 185/334 (55%), Gaps = 9/334 (2%)
Query: 205 VNRTTESGF-TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 263
++ TES T L +A G+ + LL RGA+++ + G TPL +A+ G+ +V++
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
Query: 264 LLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
LLD G I+A++ R TPL A G +VVELLL RGA R + +PL +AA G
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
Query: 323 HVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFT 379
+V +K LL A ++ T L + L +AA GH KLLLD ++ NA+ N T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
Query: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA---SP 436
L +AC + R +V+ LL+ A+++ ++GLTP+ AA G+ + +LL GA +P
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
V + R +TAL +AA G + L+ GA +D R ++ TPL +A+ G ++VQLL+
Sbjct: 1315 PVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
Query: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Q A DAA TPL + R+G V V L++
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 163 bits (412), Expect = 2e-39
Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)
Query: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+S+ + + A G+ + V L+ G I ++ G L LAA GHVG+V+ LL G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
Query: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+ +++ +++ +T L +A G+ EVV++L+ GAN ++ + +TPL +AA +++++
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
+ T+ +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Query: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+ + T L +A+ +G+ +LL+ RG ID + + G TPL AA GH VV+L
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1425
Score = 162 bits (411), Expect = 2e-39
Identities = 130/370 (35%), Positives = 185/370 (50%), Gaps = 42/370 (11%)
Query: 101 NINAQSQ-NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
+I+AQ++ N T L +A H ++V+ LLE GA+ + GFTPL +A GH V
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 160 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 219
ILL+N I A+ + TK TPL +A
Sbjct: 1134 ILLDNGAD---------IEAQSERTKD---------------------------TPLSLA 1157
Query: 220 AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-- 277
G V LLL RGA + + TPL +A+ G N++K+LL+ G +I+++T
Sbjct: 1158 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217
Query: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAP 336
G++PL AA +GH V+LLL+ G+ + A+ + N + L +A E V LL KA
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN 1277
Query: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF--TPLHIACKKNRIKVME 394
V+ LT L AA G+ V ++LLDK A+ NA + T L IA K K E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337
Query: 395 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 454
LL+ GA I + G TP+ +AA GHL++V LL+Q GA D + R T L A R G
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397
Query: 455 QVEVVRCLLR 464
V+VVR L++
Sbjct: 1398 HVKVVRYLVK 1407
Score = 153 bits (387), Expect = 1e-36
Identities = 115/331 (34%), Positives = 169/331 (51%), Gaps = 10/331 (3%)
Query: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
T N T L +A G+ +V+ LL+RG I+ + + G TPL AA +GH VVE+LL+
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 301 GAPLLA---RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
GA + A RTK+ +PL +A G E V+ LL A + + T L +AA G+
Sbjct: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
Query: 358 RVTKLLLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPI 414
+ K+LL+ A N+R + G +PL +A ++LL+ G+ I A E+ T +
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
Query: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-- 472
+A F G +V LLL A+ + G T L AA G EV R LL GA V+A
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
Query: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
T L IA+ G + +LL+ AH D G TPL ++A G +DV +L++AG
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
Query: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
A A + TPL A + G + V + L++
Sbjct: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 76.6 bits (187), Expect = 2e-13
Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 15 LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
+ AA G + L G D+N + AL +AA +GH + L+GRG+ +D
Sbjct: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
Query: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
KKGNT L +A+ G +VV++LV+ GA+++A TPL A ++ H+ VV+YL++
Sbjct: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1408
Query: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
NQ + + +A + + + +E+ + K R A + K+A++LL+
Sbjct: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1461
Score = 32.0 bits (71), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
++ N AA G+LD V ++ G D++ + + L A ++GHV +V+ L+
Sbjct: 1348 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 237 bits (605), Expect = 7e-62
Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)
Query: 294 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 342
V L+ A L R K S H A Q D V V+ LL V++ T
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
Query: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 401
+ + L +A G+Y + ++LL AN R G TPL A + +++LL+ + A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
Query: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
+ + + +G T + A G ++IV +LL GA+ + N G T L AA AG VEV R
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 462 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
LL +GA ++ + E +++ L +A G ++V+ LL+ A + T +T L + +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
V+VA +LL++GA ++ +PL +AA G +++A LL++R A + G TPL
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
Query: 581 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639
AA ++++ LLL +GA+ +A T + T L +A ++A L+ GA+ +
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
Query: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
TPL ASQEGH ++V LL GAN+H +T +G T+L A + +VAD+L + GAD
Sbjct: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
Query: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 758
+ ++ G TPL+ A G++ V FL+ +GANVN A N +T + A GH ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
Query: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 812
LL HGA P +G+T L A + G+ +VV L V + TT + +
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
Query: 813 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 856
VP T L D + +E + G G + L+ D LPS
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
Score = 214 bits (546), Expect = 5e-55
Identities = 167/512 (32%), Positives = 252/512 (49%), Gaps = 25/512 (4%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNG 466
E G TP+ AA GHL V L+ GA+ + T T + +A G + VV LL +G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
A R ++ T L A++ G T +V LL +
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 163 bits (412), Expect = 2e-39
Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)
Query: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181
I V + G+N S+ T + TP + + Q N A + P++ I A
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
Query: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 235
+ AL L + +++ R + GFTPL +AA G+V V +LL++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 236 AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
++ + R TPL +A G +V LLL RG + + TPL AA G+ ++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 295 ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 351
++LL GA + +RT K G+SPL +AA HV VK LL + ++ + + TAL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 409
G V LLLD++AN RA G TPL A +V +L+ GA + A + S
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
T + +AA GH LL+ GA DV N +G T L +A+ G +VV+ L++ GA V
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Query: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHM 499
DA + TPL A R G ++VQ L++ +
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
Score = 161 bits (407), Expect = 6e-39
Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)
Query: 403 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
I A TES T + +A GH +V +L+ A + + +G T L +AA AG V VV
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 462 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
LL G ++A++ R + TPL +A G+ E+V LLL A+ + + YTPL ++A G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 521 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577
V++ +LL AGA + T K G +PL +AA G + KLLL + ++ + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 637 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
V T L +A+ +GH LL+ +GA+I + K G T L LA+ +V +L +
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
GAD DA TPL+ A G+VK+V +L+K+
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 152 bits (384), Expect = 3e-36
Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)
Query: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+S+ + + A G+ + V + I ++ G L LAA GHVG+V+ LL +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +++++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
+ + +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+ + T L +A+ +G+ +LL+ RG ID + + G TPL A+ GH VV+L
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
Score = 145 bits (365), Expect = 5e-34
Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)
Query: 469 VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
+DA T L +A G E+V +L+ A + G+TPL ++A G V V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 528 LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
LL+ G A S TK TPL +A G +V LLL R A + + TPL +AA
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 585 YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 641
+ +LL GA ++ +K G +PL +AA + LL+ G++ N +
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
T L LA +G ++V+LLLD+ AN+ K+GLT L AA V +L GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 702 AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
A T L +A G+ K L+ +GA+++ + K G TPL A+ GH ++ +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 813
+Q GA +A T L A R G++ VV L K V + E TIT+K L
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
Query: 814 VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 853
E + + ++ + L+ DL++ ++S
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
Score = 120 bits (301), Expect = 1e-26
Identities = 102/376 (27%), Positives = 170/376 (45%), Gaps = 66/376 (17%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 67
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
Query: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKD 182
L+E GAN ++G+TPL A ++GH + VA+LL N + + AL +A
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 183 DTKSAALLLQNDHNADVQ------------------------SKMMVNRTTESGFTPLHI 218
++ A L++ AD++ S V+ TT +G T L
Sbjct: 517 FSEVADFLIKA--GADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574
Query: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT--- 275
A G+ +VA +LL GA ++ + G TPL A++ G+ V+ L+ +G ++ T
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 276 -------------------------------RDGLTPLHCAARSGHDQVVELLLERGAPL 304
+DG T L AA+ GH VV LL+ +
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Query: 305 LARTKNGLSPLHMAAQ 320
L+ +S L +Q
Sbjct: 695 LSVPTTDVSQLPPPSQ 710
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 237 bits (605), Expect = 7e-62
Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)
Query: 294 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 342
V L+ A L R K S H A Q D V V+ LL V++ T
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
Query: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 401
+ + L +A G+Y + ++LL AN R G TPL A + +++LL+ + A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
Query: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
+ + + +G T + A G ++IV +LL GA+ + N G T L AA AG VEV R
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 462 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
LL +GA ++ + E +++ L +A G ++V+ LL+ A + T +T L + +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
V+VA +LL++GA ++ +PL +AA G +++A LL++R A + G TPL
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
Query: 581 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639
AA ++++ LLL +GA+ +A T + T L +A ++A L+ GA+ +
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
Query: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
TPL ASQEGH ++V LL GAN+H +T +G T+L A + +VAD+L + GAD
Sbjct: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
Query: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 758
+ ++ G TPL+ A G++ V FL+ +GANVN A N +T + A GH ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
Query: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 812
LL HGA P +G+T L A + G+ +VV L V + TT + +
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
Query: 813 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 856
VP T L D + +E + G G + L+ D LPS
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
Score = 214 bits (546), Expect = 5e-55
Identities = 167/512 (32%), Positives = 252/512 (49%), Gaps = 25/512 (4%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNG 466
E G TP+ AA GHL V L+ GA+ + T T + +A G + VV LL +G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
A R ++ T L A++ G T +V LL +
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 163 bits (412), Expect = 2e-39
Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)
Query: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181
I V + G+N S+ T + TP + + Q N A + P++ I A
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
Query: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 235
+ AL L + +++ R + GFTPL +AA G+V V +LL++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 236 AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
++ + R TPL +A G +V LLL RG + + TPL AA G+ ++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 295 ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 351
++LL GA + +RT K G+SPL +AA HV VK LL + ++ + + TAL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 409
G V LLLD++AN RA G TPL A +V +L+ GA + A + S
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
T + +AA GH LL+ GA DV N +G T L +A+ G +VV+ L++ GA V
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Query: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHM 499
DA + TPL A R G ++VQ L++ +
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
Score = 161 bits (407), Expect = 6e-39
Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)
Query: 403 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
I A TES T + +A GH +V +L+ A + + +G T L +AA AG V VV
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 462 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
LL G ++A++ R + TPL +A G+ E+V LLL A+ + + YTPL ++A G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 521 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577
V++ +LL AGA + T K G +PL +AA G + KLLL + ++ + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 637 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
V T L +A+ +GH LL+ +GA+I + K G T L LA+ +V +L +
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
GAD DA TPL+ A G+VK+V +L+K+
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 152 bits (384), Expect = 3e-36
Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)
Query: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+S+ + + A G+ + V + I ++ G L LAA GHVG+V+ LL +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
+++ +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +++++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
+ + +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
+ + T L +A+ +G+ +LL+ RG ID + + G TPL A+ GH VV+L
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
Score = 145 bits (365), Expect = 5e-34
Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)
Query: 469 VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
+DA T L +A G E+V +L+ A + G+TPL ++A G V V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 528 LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
LL+ G A S TK TPL +A G +V LLL R A + + TPL +AA
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 585 YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 641
+ +LL GA ++ +K G +PL +AA + LL+ G++ N +
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
T L LA +G ++V+LLLD+ AN+ K+GLT L AA V +L GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 702 AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
A T L +A G+ K L+ +GA+++ + K G TPL A+ GH ++ +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 813
+Q GA +A T L A R G++ VV L K V + E TIT+K L
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
Query: 814 VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 853
E + + ++ + L+ DL++ ++S
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
Score = 120 bits (301), Expect = 1e-26
Identities = 102/376 (27%), Positives = 170/376 (45%), Gaps = 66/376 (17%)
Query: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 67
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
Query: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKD 182
L+E GAN ++G+TPL A ++GH + VA+LL N + + AL +A
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 183 DTKSAALLLQNDHNADVQ------------------------SKMMVNRTTESGFTPLHI 218
++ A L++ AD++ S V+ TT +G T L
Sbjct: 517 FSEVADFLIKA--GADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574
Query: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT--- 275
A G+ +VA +LL GA ++ + G TPL A++ G+ V+ L+ +G ++ T
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 276 -------------------------------RDGLTPLHCAARSGHDQVVELLLERGAPL 304
+DG T L AA+ GH VV LL+ +
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Query: 305 LARTKNGLSPLHMAAQ 320
L+ +S L +Q
Sbjct: 695 LSVPTTDVSQLPPPSQ 710
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 233 bits (594), Expect = 1e-60
Identities = 138/385 (35%), Positives = 207/385 (53%)
Query: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
+N ++PLH VE V+ LL H+ VD T T L +AA + LLL A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 369 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 428
+ N +G+ PLH A + LL+ +GA + A G TP+H+AA N+ L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
L+ A P++ G+T LH+AA G V +V+ L GA +DA+ R +TPLH+A GK
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548
+Q LL+ A PDA +GY PLH +A G+ + +LL GA+ L T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
AA G L++ LL + A + G TPLH+AA + + V LL+ GA P+A ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
+TPLH+A +++ LL + A + K G TP HLA+ +G+T ++ +L++ GA +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 669 MSTKSGLTSLHLAAQEDKVNVADIL 693
+ T L LA + K + L
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 223 bits (569), Expect = 1e-57
Identities = 140/377 (37%), Positives = 204/377 (54%)
Query: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
I E+ +TP+H G + V LLL + D G T L +AA+ Q ++ LL +
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
GA + + PLH A++ G +LLL H A DA G+TPLH++A+ +VA
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
+L+ A +L +G TPLHVAA +G + + KLL + A D+ +N TPLH+A
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
+ LL+ GA P A ++GY PLH AA + + I LL YGA + T QG TPL
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705
HLA+ +GH +++ LL + AN+ T LHLAA+ + V L + GAD +A +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
Query: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
G+TPL +A V LL+ ANV+A+ K G+TP H AA +G+T I+ VL++ GA+
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Query: 766 PNATTANGNTALAIAKR 782
+ T L +A R
Sbjct: 718 LDVQDGVSCTPLQLALR 734
Score = 221 bits (564), Expect = 4e-57
Identities = 138/402 (34%), Positives = 212/402 (52%), Gaps = 2/402 (0%)
Query: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269
E+ TPLH G+V LLL VD +G TPL +A++ ++ LLL G
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 270 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
+ DG PLH AA++G D LLL+ GA + A+ + G +PLH+AAQ + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389
L+ +A + + T LHVAA+ GH + KLL + A +A+ N TPLH+A ++ +
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
++ ++ L+K GA A+ +SG P+H AA G I +LL+ GAS ++ +G T LH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509
AA G +E++ L + A + A TPLH+A+R G+ +V LLQ A P+AA +G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
+TPLH++ + LLE A K G+TP H+AA G+ + K+L++ A D
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 611
TPL +A ++K ++ +G P G P
Sbjct: 720 VQDGVSCTPLQLALR--SRKQGIMSFLEGKEPSVATLGGSKP 759
Score = 221 bits (564), Expect = 4e-57
Identities = 139/401 (34%), Positives = 205/401 (51%), Gaps = 2/401 (0%)
Query: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
N +TPLH +G+ V+LLL +D +T G TPL AA+ + LLL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 304 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
++G +PLH AAQ + LL H A VD + T LH+AA V +LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 423
+ ++A+PN G TPLH+A + +++LL GA + A + TP+H+A G +
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 424 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 483
+ LL++GA PD + G LH AA G+ + + LLR GA ++ + TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 484 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 543
+ G EI+ LL + A+ A +TPLH++AR G+ V S LL+ GA + A + G+
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
Query: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
TPLH+A + + LL+ A + K G TP H+AA N + +L+E GA
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
Query: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644
TPL +A + + I S L G E ++ T G P
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 221 bits (564), Expect = 4e-57
Identities = 136/381 (35%), Positives = 202/381 (53%), Gaps = 8/381 (2%)
Query: 171 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230
++ LH + + LLL ++ + D Q T SG+TPL IAA ++ L
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ--------TASGYTPLLIAAQDQQPDLCAL 413
Query: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290
LL GA + +G PLH A++ G+ +LLLD G +DA+ R+G TPLH AA++
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
Query: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350
+ V LL+ R A G +PLH+AA HV VK L A +D + T LH+
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Query: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
A G R + LL A P+A +G+ PLH A + + + ++L++YGAS++ T G
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
Query: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
TP+H+AA+ GHL I+ LL ++ A+ T LH+AAR G+ VV LL+ GA +
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
Query: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
A + TPLH+A + V LL+H A+ A G+TP H++A +G + VL+E
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
Query: 531 AGAAHSLATKKGFTPLHVAAK 551
AGA + TPL +A +
Sbjct: 714 AGAQLDVQDGVSCTPLQLALR 734
Score = 218 bits (555), Expect = 4e-56
Identities = 137/389 (35%), Positives = 203/389 (52%)
Query: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
+TPLH G + V LLL + +T +G +PL +AAQ + LL H A +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 398
V D LH AA G +LLLD A +A+ G+TPLH+A + N V LLV
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 399 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 458
A G TP+HVAA+ GH+++V LL GA D T LH+A G+V
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 459 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 518
++ LL++GA+ DA + PLH A+ GK I ++LL++ A + T G+TPLH++A
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 519 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 578
+G +++ +L E+ A +TPLH+AA++G V LLQ A ++A ++G TP
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
Query: 579 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 638
LH+A + LLE A+ HA K G+TP H+AA K I L+ GA+ ++
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
Query: 639 KQGVTPLHLASQEGHTDMVTLLLDKGANI 667
TPL LA + +++ L K ++
Sbjct: 723 GVSCTPLQLALRSRKQGIMSFLEGKEPSV 751
Score = 210 bits (535), Expect = 9e-54
Identities = 134/399 (33%), Positives = 196/399 (49%), Gaps = 2/399 (0%)
Query: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404
+T LH G +LLL + + + +G+TPL IA + + + LL+ +GA
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 405 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
+ E G P+H AA G LLL +GA D G T LH+AA+ V R L+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
A + E +TPLH+A+ G +V+LL A DA N TPLH++ G+V
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
LL++GA + G+ PLH AA G + K+LL+ A+ + G TPLH+AA+
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 585 YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644
+ ++ LL E A+ A +TPLH+AA+ + + S LL GA+ N + G TP
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
Query: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 704
LHLA Q V LL+ AN+H K G T HLAA + + +L + GA D
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
Query: 705 KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
+ TPL +A +++FL +G + T G P
Sbjct: 723 GVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 209 bits (532), Expect = 2e-53
Identities = 144/439 (32%), Positives = 211/439 (48%), Gaps = 39/439 (8%)
Query: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166
+N TPL+ + ++ V+ LL + + T G+TPL +A Q A+LL
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA--- 416
Query: 167 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 226
H AD NR E G+ PLH AA G+
Sbjct: 417 ----------------------------HGADA------NRVDEDGWAPLHFAAQNGDDG 442
Query: 227 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
A LLL+ GA VD R G TPLH+A++ N+ +LL+ R + +G TPLH AA
Sbjct: 443 TARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAA 502
Query: 287 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 346
GH +V+LL +GA L A+ +N +PLH+A + V ++HLL+ A D +
Sbjct: 503 YFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG 562
Query: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
LH AA G Y + K+LL A+ G+TPLH+A K ++++ LL + A++ A+
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
TP+H+AA G +V LLQ GA P+ G T LH+A + V LL +
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Query: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526
A V AR + TP H+A+ G T I+++L++ A D TPL ++ R + + S
Sbjct: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMS 742
Query: 527 VLLEAGAAHSLATKKGFTP 545
L G S+AT G P
Sbjct: 743 FL--EGKEPSVATLGGSKP 759
Score = 208 bits (530), Expect = 3e-53
Identities = 139/426 (32%), Positives = 210/426 (49%), Gaps = 8/426 (1%)
Query: 355 GHYRVTKLLLDKRAN--PNARAL----NGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408
G+Y L L R N P L N TPLH + ++ + LL+ + + T
Sbjct: 334 GNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA 393
Query: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468
SG TP+ +AA ++ LLL +GA + + G LH AA+ G R LL +GA
Sbjct: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
Query: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
VDA+ RE TPLH+A++ + +LL+ A P+ G TPLH++A G V + +L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Query: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
GA + TPLH+A + G + + LL+ A D+ ++G PLH AA
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
+ +LL GAS G+TPLH+AA K ++I L A + TPLHLA
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Query: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
++ G +V+ LL GA+ + + +SG T LHLA Q L +H A+ A K+G+
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
Query: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
TP +A GN ++ L++ GA ++ + TPL A + I++ L G +P+
Sbjct: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSV 751
Query: 769 TTANGN 774
T G+
Sbjct: 752 ATLGGS 757
Score = 196 bits (499), Expect = 1e-49
Identities = 132/413 (31%), Positives = 202/413 (48%), Gaps = 37/413 (8%)
Query: 41 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 100
+N + LH +G V V+ LL VD T G T L IA+ Q ++ +L+ GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 101 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 160
+ N ++G+ PL+ AAQ + LL++GA +G+TPL +A Q +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220
L+ P LH A G TPLH+AA
Sbjct: 480 LVSRQAD-----PNLHEA--------------------------------EGKTPLHVAA 502
Query: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280
++G+V++ LL ++GA +D RN TPLH+A +RG ++ LL G DA + G
Sbjct: 503 YFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG 562
Query: 281 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340
PLH AA G + ++LL GA L T G +PLH+AA H+E + L + A + +
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
T LH+AA G V LL A+PNA +G+TPLH+A +++ + L+++
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Query: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 453
A++ A + G TP H+AA G+ I+ +L++ GA DV + T L +A R+
Sbjct: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
Score = 174 bits (442), Expect = 6e-43
Identities = 107/285 (37%), Positives = 149/285 (52%)
Query: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 567
N TPLH +G V+ +LL T G+TPL +AA+ D+ LLL A
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 568 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627
A+ ++G PLH AA + A LLL+ GA A + G+TPLH+AA+ N +A L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 628 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 687
++ A+ N+ +G TPLH+A+ GH +V LL +GA + ++ T LHLA + KV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
L K GA DA + GY PL A G + LL+ GA++ T G+TPLH A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
A +GH II++L + A A A T L +A R G +VV L
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 166 bits (420), Expect = 2e-40
Identities = 114/380 (30%), Positives = 189/380 (49%), Gaps = 12/380 (3%)
Query: 21 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 80
G++++V L +D++ +G L +AA++ L LL G+ + + G L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 81 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATE 140
H A+ G ++L+ GA ++AQ + G+TPL++AAQ N +V + L+ A+ +
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
Query: 141 DGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 196
+G TPL VA GH V +L E D + + LH+A + ++ LL
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL----- 547
Query: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
+S + + +SG+ PLH AA G + +LL GA+++ G TPLH+A+ +G
Sbjct: 548 ---KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
Query: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 316
+ ++ LL + + A TPLH AAR G + VV LL+ GA A ++G +PLH
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664
Query: 317 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 376
+A Q V +LL+H A V T H+AA G+ + K+L++ A + +
Sbjct: 665 LAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV 724
Query: 377 GFTPLHIACKKNRIKVMELL 396
TPL +A + + +M L
Sbjct: 725 SCTPLQLALRSRKQGIMSFL 744
Score = 141 bits (355), Expect = 7e-33
Identities = 85/215 (39%), Positives = 116/215 (53%), Gaps = 4/215 (1%)
Query: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
+N +TPLH + + LLL +GYTPL IAA+ Q + + LL +GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
+ N V + G PLH A+Q G LLLD GA + + G T LHLAAQ + NVA +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
L AD + H G TPL VA ++G+V +V L QGA ++A+ +N TPLH A ++G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 753 THIINVLLQHGAKPNATTANG----NTALAIAKRL 783
I LL+ GA P+A +G +TA A K L
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Score = 137 bits (346), Expect = 7e-32
Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 15/305 (4%)
Query: 15 LRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73
L A N + V L D N G LH+AA GHV LV+ L +G+ +D+
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
Query: 74 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133
+ T LH+A G+ ++ L+K GA +A Q+G+ PL+ AA + K LL GA
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAAL 189
+ T G+TPL +A +GH + + +L E+ G V LH+AAR + +
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 190 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 249
LLQ AD N +SG+TPLH+A LL A V + G TP
Sbjct: 645 LLQ--CGAD------PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696
Query: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
H+A+ +GNT ++K+L++ G Q+D + TPL A RS Q + LE P +A T
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGKEPSVA-TL 754
Query: 310 NGLSP 314
G P
Sbjct: 755 GGSKP 759
Score = 110 bits (274), Expect = 2e-23
Identities = 77/282 (27%), Positives = 134/282 (47%), Gaps = 16/282 (5%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
L +++ AA G++ V G +++ +N LHLA + G V +Q LL
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
G+ D+ + G LH A+ G+ + K+L++ GA++ + G+TPL++AA + H+++
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
Query: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAA 179
+ L E+ AN +TPL +A + G V+ LL+ N + P LH+A
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP-LHLAV 667
Query: 180 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239
++ S LL++ N ++K+ G+TP H+AA GN + +L+ GA +D
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKV--------GWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
TPL +A + ++ L G + T G P
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 100 bits (250), Expect = 1e-20
Identities = 60/187 (32%), Positives = 90/187 (48%)
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
+N TPLH + ++ LL + + + T G TPL +A+Q+ D+ LLL GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
+ + + G LH AAQ A +L HGA DA + G+TPL +A +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
L+ + A+ N G TPLH AA GH ++ +L GA+ +A N T L +A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 786 ISVVDTL 792
+ + L
Sbjct: 540 VRAIQHL 546
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 209 bits (531), Expect = 3e-53
Identities = 170/571 (29%), Positives = 269/571 (47%), Gaps = 58/571 (10%)
Query: 47 LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
+H AA G G +Q L+ G + D + G T L LA + + L+K GA++N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 106 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL--- 162
+ T L++AAQ+ + +K LL AN + TPL + + + +A+LL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 163 ---ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 219
E DT+ K + ALH +A ++ + LL+++D N + G PLH A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV--------EGKIPLHWA 189
Query: 220 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
A++ + V+ +L+ + +++ G TPLH A GN +V +L +
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNI 248
Query: 274 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 330
+ D L TPLH AA GH Q+V LLLER + + G +PLH AAQ + E VK
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308
Query: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
L+H + DD L+ T+ AA G V + +L +++ +
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349
Query: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
+ + KYG T +H AA GH++ V LLL+N A D T++ T L A
Sbjct: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
Query: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
G +V++ L++ GA VD ++ + LH A+ G ++ Q+L+++ +P+ G
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
Query: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
TPL +A G ++ +VL+E A ++ K+G T LH + G LD KLLL A +
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 571 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 599
N TPL A + +V +LE GA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 193 bits (491), Expect = 1e-48
Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)
Query: 282 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340
+H AA +G ++ L+ + L + G +PL D ++C LL+ A V+
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
TALH+AA G+YR KLLL +RAN + L TPLH+ + K + LL+K+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 401 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 455
A + T+ + T +H +A+ + V LL+++ ++ + ++ G+ LH AA
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 456 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 511
V VRC+L +L++ + E +TPLH A G +V +L + + + N + T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 512 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
PLH +A G + +LLE + ++ + +G TPLH AA+ + K+ L+ + D
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 571 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ G T AA + V +L L+ + K G T LH AA + LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 688
A+ + TPL A + GH D++ L+ GA + + + G + LH AA +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Query: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
V IL ++ + + G TPL A + G + + L++ A+ N + K G T LH +
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
Query: 749 QQGHTHIINVLLQHGAKPNATTAN 772
G+ I +LL A PN N
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENN 521
Score = 172 bits (436), Expect = 3e-42
Identities = 151/543 (27%), Positives = 250/543 (46%), Gaps = 25/543 (4%)
Query: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
+Q G L + LL G+ V+ TALH+A+ G +K+L+
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 100 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN--QA 157
AN + TPL++ + + LL+ A T+D A+ +N +
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164
Query: 158 VAILLENDT-------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
V +L+++D+ +GK+ LH AA D + + A +S ++N
Sbjct: 165 VKLLIKHDSNIGIPDVEGKI---PLHWAANHKDPSAVHTVRCILDAAPTES--LLNWQDY 219
Query: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDR- 267
G TPLH A GNV V +L + + + T+ + + TPLH A+ G+ +V LLL+R
Sbjct: 220 EGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278
Query: 268 -GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
G I + ++ G TPLH AA+S + V++ L+ + G + AA +
Sbjct: 279 KSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 327 VKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
++ +L K+ +D D TALH AA GH KLLL+ A +A + TPL A
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
Query: 385 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 444
C+ V++ L+K GA + + + G + +H AA G+ ++ +L++N +P+V + G
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
Query: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
T L AA G + + L+ N A + + +E +T LH + G + ++LLL A P+
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 505 ATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
N YTPL + + +V +LE GA S+A + + A Y V K
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQAVYKGYKVRKAFR 576
Query: 563 QRR 565
R+
Sbjct: 577 DRK 579
Score = 162 bits (410), Expect = 3e-39
Identities = 131/458 (28%), Positives = 217/458 (47%), Gaps = 13/458 (2%)
Query: 348 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
+H AA G + +L++ A + G TPL +R+ + L+K GA +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
S T +H+AA G+ + LLL A+ ++ T LH+ R + + LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 467 AL--VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE---GQ 521
A VD + + +QT LH ++ E V+LL++H ++ G PLH +A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 522 VDVASVLLEAGAAHSLAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-T 577
V +L+A SL +G TPLH A G++ V +L + ++ N T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGAETNI 636
PLH AA + ++ LLLE+ S + + G TPLH AA+ N + L + + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 637 VTKQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILT 694
+G T A+ +G D++ +L +I+M+ K G T+LH AA V+ +L
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 695 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 754
++ A DA + +TPL AC G+ ++ L+K GA V+ ++G++ LH AA G+
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Query: 755 IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+ +L+++ PN G T L A GYI+ + L
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Score = 161 bits (408), Expect = 5e-39
Identities = 162/589 (27%), Positives = 260/589 (44%), Gaps = 61/589 (10%)
Query: 60 QELLGRGSSVDSATKKGNTALHIASLAG-QAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118
+ LL GSS+ S +H A++ G + + +++V A + + Q G TPL
Sbjct: 5 ENLLFAGSSLASQ-------VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57
Query: 119 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 178
+ +D LL+ GA+ + + H+Q A LH+A
Sbjct: 58 ADRLDCADALLKAGADVN--------------KTDHSQRTA---------------LHLA 88
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA- 237
A+K + + LLL N + + E TPLH+ + + LLL A
Sbjct: 89 AQKGNYRFMKLLLTRRAN-------WMQKDLEE-MTPLHLTTRHRSPKCLALLLKFMAPG 140
Query: 238 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
VD +N T LH ++ N VKLL+ I +G PLH AA V
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
Query: 297 L--LERGAP----LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TAL 348
+ + AP L + G +PLH A +V V L +++ + + D L T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNITSYDNLFRTPL 259
Query: 349 HVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
H AA GH ++ LLL++ + + G TPLH A + N + +++ +K+ +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
Query: 408 ESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
G T AA G +++ +L L++ ++ + G TALH AA +G V V+ LL N
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
A VDA + TPL A +G +++Q L++ A D +G++ LH +A G DV
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
+L+E ++ G TPL AA G ++ +L++ A + K G T LH + +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 586 DNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 632
LLL+ A P+ N YTPL A + ++ +L +GA
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 151 bits (382), Expect = 5e-36
Identities = 143/502 (28%), Positives = 218/502 (43%), Gaps = 63/502 (12%)
Query: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS----------- 68
A LD LK G D+N + + ALHLAA++G+ ++ LL R ++
Sbjct: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
Query: 69 ------------------------VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 104
VD+ K TALH ++ E VK+L+K +NI
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177
Query: 105 QSQNGFTPLYMAAQENHID-----VVKYLLENGANQSTAT---EDGFTPLAVALQQGHNQ 156
G PL+ AA NH D V+ +L+ +S +G TPL A+ G+
Sbjct: 178 PDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT 235
Query: 157 AVAILLENDT------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
V +L ++ R P LH AA + LLL+ + + + S
Sbjct: 236 VVDVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPS-------DS 287
Query: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
G TPLH AA + L + D + G T A+ +G+ ++++ +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 271 IDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 328
ID D G T LH AA SGH V+LLLE A + A +PL A + H + ++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 329 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
L++ A VD V D + LH AA G+ V ++L++ + NPN + G TPL A
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 389 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNIRGETA 446
I M +L++ A + G T +H + G+L+ + LLL A P+ N T
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 447 LHMAARAGQVEVVRCLLRNGAL 468
L A + EV++ +L +GAL
Sbjct: 528 LDYALLGERHEVIQFMLEHGAL 549
Score = 108 bits (270), Expect = 5e-23
Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)
Query: 480 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 538
+H A+ G K + +L++ + A D G TPL ++D A LL+AGA +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 539 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598
T LH+AA+ G+ KLLL RRA +TPLH+ + + K LLL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 599 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 655
A KN T LH +A N + L+ + + I +G PLH A+ H D
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195
Query: 656 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 707
V +LD ++ G T LH A + V V D+LT + + ++ L
Sbjct: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 766
TPL A G+ ++V+ LL++ + + + G TPLH AAQ + V L+H +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 767 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 799
+ + G T+ A G V+ T+ + ++
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Score = 92.8 bits (229), Expect = 3e-18
Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)
Query: 9 DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+ SF+ AA G+ D + + LK IDIN ++ G ALH AA GHV V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
+ VD+ +T L A G +V++ L+K GA ++ Q+G + L+ AA + DV +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
Query: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 182
L+EN N + G TPL A G+ +A+L+EN+ + K ALH +
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
Query: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 236
+ LLL D + E +TPL A V +L GA
Sbjct: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/139 (27%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
L D ++ AA GN D ++ I+ N + G L AA G++ + L+
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN--GFTPLYMAAQENHI 122
+ + K+G TALH + G + +K+L+ A N N +TPL A
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537
Query: 123 DVVKYLLENGANQSTATED 141
+V++++LE+GA A +D
Sbjct: 538 EVIQFMLEHGALSIAAIQD 556
Score = 51.6 bits (122), Expect = 7e-06
Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 2/163 (1%)
Query: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
G TPL D LL GA+++ + S T+LHLAAQ+ +L A+
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGA--NVNAKTKNGYTPLHQAAQQGHTHIINV 758
TPL + + + K + LLK A V+ + KN T LH +A + + +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
L++H + G L A S V T++ + + T
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 209 bits (531), Expect = 3e-53
Identities = 170/571 (29%), Positives = 269/571 (47%), Gaps = 58/571 (10%)
Query: 47 LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
+H AA G G +Q L+ G + D + G T L LA + + L+K GA++N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 106 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL--- 162
+ T L++AAQ+ + +K LL AN + TPL + + + +A+LL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 163 ---ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 219
E DT+ K + ALH +A ++ + LL+++D N + G PLH A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV--------EGKIPLHWA 189
Query: 220 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
A++ + V+ +L+ + +++ G TPLH A GN +V +L +
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNI 248
Query: 274 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 330
+ D L TPLH AA GH Q+V LLLER + + G +PLH AAQ + E VK
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308
Query: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
L+H + DD L+ T+ AA G V + +L +++ +
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349
Query: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
+ + KYG T +H AA GH++ V LLL+N A D T++ T L A
Sbjct: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
Query: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
G +V++ L++ GA VD ++ + LH A+ G ++ Q+L+++ +P+ G
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
Query: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
TPL +A G ++ +VL+E A ++ K+G T LH + G LD KLLL A +
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 571 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 599
N TPL A + +V +LE GA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 193 bits (491), Expect = 1e-48
Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)
Query: 282 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340
+H AA +G ++ L+ + L + G +PL D ++C LL+ A V+
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
TALH+AA G+YR KLLL +RAN + L TPLH+ + K + LL+K+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 401 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 455
A + T+ + T +H +A+ + V LL+++ ++ + ++ G+ LH AA
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 456 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 511
V VRC+L +L++ + E +TPLH A G +V +L + + + N + T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 512 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
PLH +A G + +LLE + ++ + +G TPLH AA+ + K+ L+ + D
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 571 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
+ G T AA + V +L L+ + K G T LH AA + LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 688
A+ + TPL A + GH D++ L+ GA + + + G + LH AA +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Query: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
V IL ++ + + G TPL A + G + + L++ A+ N + K G T LH +
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
Query: 749 QQGHTHIINVLLQHGAKPNATTAN 772
G+ I +LL A PN N
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENN 521
Score = 172 bits (436), Expect = 3e-42
Identities = 151/543 (27%), Positives = 250/543 (46%), Gaps = 25/543 (4%)
Query: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
+Q G L + LL G+ V+ TALH+A+ G +K+L+
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 100 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN--QA 157
AN + TPL++ + + LL+ A T+D A+ +N +
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164
Query: 158 VAILLENDT-------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
V +L+++D+ +GK+ LH AA D + + A +S ++N
Sbjct: 165 VKLLIKHDSNIGIPDVEGKI---PLHWAANHKDPSAVHTVRCILDAAPTES--LLNWQDY 219
Query: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDR- 267
G TPLH A GNV V +L + + + T+ + + TPLH A+ G+ +V LLL+R
Sbjct: 220 EGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278
Query: 268 -GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
G I + ++ G TPLH AA+S + V++ L+ + G + AA +
Sbjct: 279 KSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 327 VKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
++ +L K+ +D D TALH AA GH KLLL+ A +A + TPL A
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
Query: 385 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 444
C+ V++ L+K GA + + + G + +H AA G+ ++ +L++N +P+V + G
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
Query: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
T L AA G + + L+ N A + + +E +T LH + G + ++LLL A P+
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 505 ATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
N YTPL + + +V +LE GA S+A + + A Y V K
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQAVYKGYKVRKAFR 576
Query: 563 QRR 565
R+
Sbjct: 577 DRK 579
Score = 162 bits (410), Expect = 3e-39
Identities = 131/458 (28%), Positives = 217/458 (47%), Gaps = 13/458 (2%)
Query: 348 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
+H AA G + +L++ A + G TPL +R+ + L+K GA +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
S T +H+AA G+ + LLL A+ ++ T LH+ R + + LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 467 AL--VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE---GQ 521
A VD + + +QT LH ++ E V+LL++H ++ G PLH +A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 522 VDVASVLLEAGAAHSLAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-T 577
V +L+A SL +G TPLH A G++ V +L + ++ N T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGAETNI 636
PLH AA + ++ LLLE+ S + + G TPLH AA+ N + L + + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 637 VTKQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILT 694
+G T A+ +G D++ +L +I+M+ K G T+LH AA V+ +L
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 695 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 754
++ A DA + +TPL AC G+ ++ L+K GA V+ ++G++ LH AA G+
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Query: 755 IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+ +L+++ PN G T L A GYI+ + L
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Score = 161 bits (408), Expect = 5e-39
Identities = 162/589 (27%), Positives = 260/589 (44%), Gaps = 61/589 (10%)
Query: 60 QELLGRGSSVDSATKKGNTALHIASLAG-QAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118
+ LL GSS+ S +H A++ G + + +++V A + + Q G TPL
Sbjct: 5 ENLLFAGSSLASQ-------VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57
Query: 119 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 178
+ +D LL+ GA+ + + H+Q A LH+A
Sbjct: 58 ADRLDCADALLKAGADVN--------------KTDHSQRTA---------------LHLA 88
Query: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA- 237
A+K + + LLL N + + E TPLH+ + + LLL A
Sbjct: 89 AQKGNYRFMKLLLTRRAN-------WMQKDLEE-MTPLHLTTRHRSPKCLALLLKFMAPG 140
Query: 238 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
VD +N T LH ++ N VKLL+ I +G PLH AA V
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
Query: 297 L--LERGAP----LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TAL 348
+ + AP L + G +PLH A +V V L +++ + + D L T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNITSYDNLFRTPL 259
Query: 349 HVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
H AA GH ++ LLL++ + + G TPLH A + N + +++ +K+ +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
Query: 408 ESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
G T AA G +++ +L L++ ++ + G TALH AA +G V V+ LL N
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
A VDA + TPL A +G +++Q L++ A D +G++ LH +A G DV
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
+L+E ++ G TPL AA G ++ +L++ A + K G T LH + +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 586 DNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 632
LLL+ A P+ N YTPL A + ++ +L +GA
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 151 bits (382), Expect = 5e-36
Identities = 143/502 (28%), Positives = 218/502 (43%), Gaps = 63/502 (12%)
Query: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS----------- 68
A LD LK G D+N + + ALHLAA++G+ ++ LL R ++
Sbjct: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
Query: 69 ------------------------VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 104
VD+ K TALH ++ E VK+L+K +NI
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177
Query: 105 QSQNGFTPLYMAAQENHID-----VVKYLLENGANQSTAT---EDGFTPLAVALQQGHNQ 156
G PL+ AA NH D V+ +L+ +S +G TPL A+ G+
Sbjct: 178 PDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT 235
Query: 157 AVAILLENDT------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
V +L ++ R P LH AA + LLL+ + + + S
Sbjct: 236 VVDVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPS-------DS 287
Query: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
G TPLH AA + L + D + G T A+ +G+ ++++ +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 271 IDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 328
ID D G T LH AA SGH V+LLLE A + A +PL A + H + ++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 329 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
L++ A VD V D + LH AA G+ V ++L++ + NPN + G TPL A
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 389 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNIRGETA 446
I M +L++ A + G T +H + G+L+ + LLL A P+ N T
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 447 LHMAARAGQVEVVRCLLRNGAL 468
L A + EV++ +L +GAL
Sbjct: 528 LDYALLGERHEVIQFMLEHGAL 549
Score = 108 bits (270), Expect = 5e-23
Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)
Query: 480 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 538
+H A+ G K + +L++ + A D G TPL ++D A LL+AGA +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 539 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598
T LH+AA+ G+ KLLL RRA +TPLH+ + + K LLL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 599 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 655
A KN T LH +A N + L+ + + I +G PLH A+ H D
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195
Query: 656 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 707
V +LD ++ G T LH A + V V D+LT + + ++ L
Sbjct: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 766
TPL A G+ ++V+ LL++ + + + G TPLH AAQ + V L+H +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 767 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 799
+ + G T+ A G V+ T+ + ++
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Score = 92.8 bits (229), Expect = 3e-18
Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)
Query: 9 DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
+ SF+ AA G+ D + + LK IDIN ++ G ALH AA GHV V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
+ VD+ +T L A G +V++ L+K GA ++ Q+G + L+ AA + DV +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
Query: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 182
L+EN N + G TPL A G+ +A+L+EN+ + K ALH +
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
Query: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 236
+ LLL D + E +TPL A V +L GA
Sbjct: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/139 (27%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
L D ++ AA GN D ++ I+ N + G L AA G++ + L+
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN--GFTPLYMAAQENHI 122
+ + K+G TALH + G + +K+L+ A N N +TPL A
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537
Query: 123 DVVKYLLENGANQSTATED 141
+V++++LE+GA A +D
Sbjct: 538 EVIQFMLEHGALSIAAIQD 556
Score = 51.6 bits (122), Expect = 7e-06
Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 2/163 (1%)
Query: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
G TPL D LL GA+++ + S T+LHLAAQ+ +L A+
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGA--NVNAKTKNGYTPLHQAAQQGHTHIINV 758
TPL + + + K + LLK A V+ + KN T LH +A + + +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
L++H + G L A S V T++ + + T
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 208 bits (529), Expect = 5e-53
Identities = 215/837 (25%), Positives = 348/837 (41%), Gaps = 106/837 (12%)
Query: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
+N + NG AL LA + L+ + VD K G + LH G L
Sbjct: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
Query: 96 VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 143
+K GA +NA + TPL++ A +++ DV+ + LL+ GAN + G
Sbjct: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
Query: 144 TPLAVALQQGHNQAVAILLE--------NDTKGKVR--LPALHIAARK------------ 181
TPL V++ G+ + LL+ D +G L HI
Sbjct: 369 TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
Query: 182 ------DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235
D+ AA L+Q + D T +G L AA GN A L G
Sbjct: 429 VNGTSFDENSFAARLIQRGSHTDAPD-------TATGNCLLQRAAGAGNEAAALFLATNG 481
Query: 236 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL---------------- 279
A V+ + G TPLH A + G N+ LL +G + +T + L
Sbjct: 482 AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV 541
Query: 280 ---TPLHCAARSGHDQVVELLLERGAPLLARTKN-------------GLSPLHMAAQGDH 323
TPLH A H VV ++LE+ A L T N + L +A
Sbjct: 542 HLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
Query: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN-ARALNGFTPLH 382
LL A ++D D T LH+A + LL+ +A+ N +R +G T L
Sbjct: 602 HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
Query: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442
+A + V++ + GA + E G P+ +A +I L+++G
Sbjct: 662 LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
Query: 443 G----ETALHMAARAGQVEVVRCLLRNGALVDA------------RAREEQTPLHIASRL 486
+T LH A L+R+G V++ AR+ QTPLH+A+
Sbjct: 722 PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781
Query: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTP 545
G E VQ LL+ A+ +A G TP+H++ + +L+ H ++ ++G TP
Sbjct: 782 GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841
Query: 546 LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604
A + + A+ +L+R + AA+ G LHVA + + L L+ A+ ++
Sbjct: 842 FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
Query: 605 AKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
++ TPLH+A + I LL GA+ N +TK T LHLA+Q+ + ++LL+
Sbjct: 902 VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
Query: 663 KGANIHMSTKSGLTSLHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYG--N 719
G + ++G +LHLA ++ N+ +LT+ D +A G +PL + YG N
Sbjct: 962 NGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021
Query: 720 VKMVNFLLKQ---GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
+ L + G ++ +G T L A +G+ ++ +++ GA+ G
Sbjct: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
Score = 168 bits (426), Expect = 4e-41
Identities = 205/787 (26%), Positives = 316/787 (40%), Gaps = 139/787 (17%)
Query: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
+N NG L +A + L+ + A+ + G++ L +Q+G A L
Sbjct: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
Query: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
++N + A + A++ AL H+ADV S+M
Sbjct: 309 IKNGAF----VNAATLGAQETPLHLVALYSSKKHSADVMSEM------------------ 346
Query: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD-RGGQIDAKTRDGLT 280
+A LL GA + G TPLHV+ GN + LL + ++ K +G T
Sbjct: 347 ---AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST 403
Query: 281 PLHCAARS---GHDQVVELLLERGAPLLARTK--NGLSPLHMAAQGDHVECVKHLLQHKA 335
L A + DQ V + P++ T + +G H + A
Sbjct: 404 ALWLAVQHITVSSDQSVNPFED--VPVVNGTSFDENSFAARLIQRGSHTD---------A 452
Query: 336 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 395
P D T + L L AA G+ L A+ N R G TPLH AC+ +
Sbjct: 453 P-DTATGNCL--LQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509
Query: 396 LVKYGASIQAITESGL-------------------TPIHVAAFMGHLNIVLLLLQNGAS- 435
L++ GA+ TE L TP+H+A H ++V ++L+ A+
Sbjct: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569
Query: 436 ----------PDVT--NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 483
PD + + R +T L +A G + LL +GA ++ + QT LH+A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
Query: 484 SRLGKTEIVQLLLQHMAHPDAATT-NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
+ ++ LL+H A + + T +G T L ++ R V + GA S+ +KG
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
Query: 543 FTPLHVAAKYGSLDVAKLLLQRRAAAD--SAGKNGL--TPLHVAAHYDNQKVALLLLEKG 598
PL +A D+A L++ A G G T LH A +N+ A L+ G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
Query: 599 ASPHAT------------AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646
++ A++G TPLH+AA + LL +GA N +G TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
Query: 647 LASQEGHTDMVTLLLDKGANIHMSTKS--GLTS--------------------------- 677
+A H ++ LL+ +IH++ + GLT
Sbjct: 810 VAISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV 868
Query: 678 -------LHLAAQEDKVNVADILTKHGAD-----QDAHTKLGYTPLIVACHYGNVKMVNF 725
LH+A Q + L A+ QDA +KL TPL +A G+ +V
Sbjct: 869 DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDA-SKL--TPLHLAVQAGSEIIVRN 925
Query: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
LL GA VN TK+ T LH AAQQ I +VLL++G A NGN AL +A G
Sbjct: 926 LLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985
Query: 786 ISVVDTL 792
++ + L
Sbjct: 986 LNNIRVL 992
Score = 152 bits (385), Expect = 2e-36
Identities = 177/638 (27%), Positives = 265/638 (41%), Gaps = 76/638 (11%)
Query: 11 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
N RAA AGN + G +N N+ G LH A + G L ELL +G++ +
Sbjct: 459 NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN 518
Query: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHIDVVKYL 128
Q E L KE A++ A S + TPL+MA NH DVV +
Sbjct: 519 L----------------QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
Query: 129 LENGANQSTATED-------------GFTPLAVALQQGHNQAVAILLE-----NDTKGKV 170
LE AN AT + T L +AL G + A LL NDT
Sbjct: 563 LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622
Query: 171 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230
+ LH+A ++ D+KSA LL +H AD+ V+R T+ G T L +A V
Sbjct: 623 Q-TLLHMAIQRQDSKSALFLL--EHQADIN----VSR-TQDGETALQLAIRNQLPLVVDA 674
Query: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP-------LH 283
+ RGA + G PL +A ++ L+ G DA T G P LH
Sbjct: 675 ICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG--CDA-TCWGPGPGGCLQTLLH 731
Query: 284 CAARSGHDQVVELLLERGAPLLA------------RTKNGLSPLHMAAQGDHVECVKHLL 331
A ++ L+ G + + ++G +PLH+AA E V+ LL
Sbjct: 732 RAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLL 791
Query: 332 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD-KRANPNARALNGFTPLHIACK-KNR 389
+ A V+ + T +HVA H + +LL+ + N R G TP A KN
Sbjct: 792 EFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNN 851
Query: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNIRGETAL 447
+L + + + + G +HVA + VL L+ A+ + V + T L
Sbjct: 852 KSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPL 911
Query: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
H+A +AG +VR LL GA V+ + QT LH+A++ I +LL++ A
Sbjct: 912 HLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDE 971
Query: 508 NGYTPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL----- 561
NG LH++ G+++ VLL E +G +PLH+ +YG + A +
Sbjct: 972 NGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLE 1031
Query: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
D +G T L +A N + ++ GA
Sbjct: 1032 CMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGA 1069
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 184 bits (467), Expect = 7e-46
Identities = 129/396 (32%), Positives = 205/396 (51%), Gaps = 3/396 (0%)
Query: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353
++ LLE+ + R + G +PL +AA+ ++E VK L+++ A + LD TAL A+
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 354 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 413
GH + + LL N R + G+T L AC K R V+ELL+ +GA+ + P
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
Query: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
I AA GH +IV LLLQNGA + ++ G T L AAR G +E V+ LL GA VD
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
T L +A + G T+ V+ +L+ + + +G T L I+++EG ++ LL+AG
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593
++ + G T L A + G +++ + LLQ+ A D G++ T L+ A N +
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
Query: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
+L+ K+G TPL A K +++ LL+ GA+ + V K+G TPLH+A +
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
Query: 654 TDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDK 686
+ LLL G ++ K+G T ++ K
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 416
Score = 183 bits (465), Expect = 1e-45
Identities = 123/377 (32%), Positives = 197/377 (52%)
Query: 386 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
++ I ++ L++ + E G TP+ +AA G+L IV L++NGA+ ++ ++ T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 446 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 505
AL A++ G V +V LL+ G ++ R T L A G+T++V+LLL H A+P
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 506 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
P+ +A G D+ +LL+ GA + + K G TPL AA+ G L+ K LL
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
A D G N +T L VA + +L++ + + T K+G T L IA+K+ +I
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
LL+ G NI + G T L A + GH ++V LL K A+I + + T+L+ A ++
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
Query: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 745
+ + + D + TK G TPLI A N+++V LL +GA V+A K G TPLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
Query: 746 QAAQQGHTHIINVLLQH 762
A + + +LL++
Sbjct: 374 IAIRGRSRKLAELLLRN 390
Score = 175 bits (443), Expect = 4e-43
Identities = 127/385 (32%), Positives = 192/385 (49%), Gaps = 12/385 (3%)
Query: 52 KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 111
+E ++ ++ LL + VD + G T L IA+ G E+VK L+K GAN N + + +T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK---- 167
L A++E H+ +V+ LL+ G N G+T L A +G V +LL +
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 168 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 227
G + + AA + LLLQN VN + + G TPL AA G++
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLEC 185
Query: 228 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287
LL GA VD N +T L VA K G T VK +L R ++ +DG T L A++
Sbjct: 186 VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASK 245
Query: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH ++V+ LL+ G + ++G + L A +G HVE V+ LLQ A +D D TA
Sbjct: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
L+ A G+ + + +L + +G TPL A K I+V+ELL+ GA + A+
Sbjct: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
Query: 408 ESGLTPIHVAAFMGHLNIVLLLLQN 432
+ G TP+H+A + LLL+N
Sbjct: 366 KKGDTPLHIAIRGRSRKLAELLLRN 390
Score = 167 bits (424), Expect = 7e-41
Identities = 141/490 (28%), Positives = 214/490 (43%), Gaps = 73/490 (14%)
Query: 118 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 177
+E +I +K LLE + E G TPL +A +QG+ + V L+
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
Query: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237
+N N +++ +T L A+ G+V++ LL G
Sbjct: 59 --------------KNGANCNLEDL--------DNWTALISASKEGHVHIVEELLKCGVN 96
Query: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
++ G T L A +G T++V+LLL G + P+ AA GH +V LL
Sbjct: 97 LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Query: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
L+ GA + K G +PL AA+ H+ECVKHLL A VD + +TAL VA G+
Sbjct: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
Query: 358 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417
+ K +L + N N +G T L IA K+
Sbjct: 217 QSVKEILKRNPNVNLTDKDGNTALMIASKE------------------------------ 246
Query: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 477
GH IV LL G ++ + G+T L A R G VE+VR LL+ A +D R ++ +
Sbjct: 247 ---GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303
Query: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 537
T L+ A G +V+ +LQ + T +G TPL + + ++V +LL+ GA S
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
Query: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKVALLL 594
KKG TPLH+A + S +A+LLL+ K G TP ++ + + +
Sbjct: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423
Query: 595 LEKGASPHAT 604
+ SP T
Sbjct: 424 GARHLSPTET 433
Score = 159 bits (403), Expect = 2e-38
Identities = 128/403 (31%), Positives = 200/403 (49%), Gaps = 24/403 (5%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
AA GNL+ V E +K G + N + + AL A+KEGHV +V+ELL G +++ G
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
TAL A G+ +VV++L+ GAN + P+ AA H D+V LL+NGA +
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
Query: 137 TATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
+ + G TPL A ++GH + V LL + D +G + AL +A + T+S +L+
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
Query: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 252
+ N VN T + G T L IA+ G+ + LL+ G V+ R+G T L A
Sbjct: 225 RNPN--------VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA 276
Query: 253 SKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL 312
+ G+ +V+ LL + ID + +D T L+ A G+ +V +L+ TK+G
Sbjct: 277 VRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGE 336
Query: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
+PL A + ++E V+ LL A V V T LH+A ++ +LLL NP
Sbjct: 337 TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL---RNPKD 393
Query: 373 RAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409
L G TP +I C + + ++ +GA + TE+
Sbjct: 394 GRLLYRPNKAGETPYNIDCSHQKSILTQI---FGARHLSPTET 433
Score = 141 bits (355), Expect = 7e-33
Identities = 110/360 (30%), Positives = 165/360 (45%), Gaps = 33/360 (9%)
Query: 456 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 515
+ ++ LL VD R QTPL IA+ G EIV+ L+++ A+ + + +T L
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
Query: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575
+++EG V + LL+ G G+T L A G DV +LLL A G
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE-- 633
+ P+ AA + + LLL+ GA + + K G TPL AA+K ++ LL GA+
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
Query: 634 -------------------------------TNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
N+ K G T L +AS+EGHT++V LLD
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
Query: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
G +++ +SG T L A + V + L + AD D + T L A GN M
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
Query: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782
V +L+ + TK+G TPL +A + + ++ +LL GAK +A G+T L IA R
Sbjct: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377
Score = 113 bits (282), Expect = 2e-24
Identities = 73/239 (30%), Positives = 118/239 (49%)
Query: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 613
++ K LL++ D + G TPL +AA N ++ L++ GA+ + + +T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
A+K+ + I LL G G T L A +G TD+V LLL GAN ++
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
+ + AA ++ +L ++GA + K G TPL+ A G+++ V LL GA+V
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+ + N T L A + G+T + +L+ N T +GNTAL IA + G+ +V L
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Score = 101 bits (252), Expect = 6e-21
Identities = 67/215 (31%), Positives = 115/215 (53%), Gaps = 9/215 (4%)
Query: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
++S + + A + G V E LK ++N +++G AL +A+KEGH +VQ+LL G+
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
V+ + G+T L A G E+V+ L+++ A+I+ + Q+ T LY A ++ + +V+
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
Query: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDD 183
+L+ + T+DG TPL A + + + V +LL+ K K LHIA R
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
Query: 184 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218
K A LLL+N + ++ R ++G TP +I
Sbjct: 381 RKLAELLLRNPKDG-----RLLYRPNKAGETPYNI 410
Score = 95.1 bits (235), Expect = 6e-19
Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 25/236 (10%)
Query: 623 IASTLLNYGAETNIVTKQ---------------GVTPLHLASQEGHTDMVTLLLDKGANI 667
I+ +++NY E NI + G TPL +A+++G+ ++V L+ GAN
Sbjct: 5 ISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64
Query: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727
++ T+L A++E V++ + L K G + + G+T L+ AC+ G +V LL
Sbjct: 65 NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
Query: 728 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 787
GAN + P+ AA +GH I+++LLQ+GAK N + G T L A R G++
Sbjct: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
Query: 788 VVDTLKV----VTEEVTTTTTTITEKHKLNVPETMTEVL------DVSDEEGDDTM 833
V L V +E + T + K +++ E+L +++D++G+ +
Sbjct: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 180 bits (457), Expect = 1e-44
Identities = 155/542 (28%), Positives = 258/542 (47%), Gaps = 38/542 (7%)
Query: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVV 92
+ C+ LH AA EG + L++++ R SS++ + GNT LH A Q E V
Sbjct: 56 LKRCDDMDTFFLHYAAAEGQIELMEKIT-RDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114
Query: 93 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQSTATEDGFTPLAVALQ 151
K L+ GAN N ++ N PL++A Q + +V+K LLE+ + + E+G T + +A
Sbjct: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174
Query: 152 QGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 207
+++A+ ILL+ K K +H AA + ++L+ ++ +N
Sbjct: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234
Query: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
TPLH+A G++ + + L+ GA +D + T +H A+ +G T +VKL++
Sbjct: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
Query: 268 -GGQID-AKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 323
G +D T DG T LH A+ H ++ + L+ GA + G SPL +A
Sbjct: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
Query: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH------------YRVTKLLLDKRANPN 371
V LL A VD LH+ + ++ +L++D+
Sbjct: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN--- 411
Query: 372 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
+G TPLH AC++ + L+ + SI + ++ +P+H AA G +N LLQ
Sbjct: 412 ----DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467
Query: 432 NGASPDVTN---IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
+ + + N + G T LH+AA+ G +VV+ LL+ GAL T LH AS G
Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGY 526
Query: 489 TEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547
T+ ++++L ++ D +G T LH +AREG ++LL A + K+ + LH
Sbjct: 527 TQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN-ADIVLNKQQASFLH 585
Query: 548 VA 549
+A
Sbjct: 586 LA 587
Score = 178 bits (451), Expect = 5e-44
Identities = 152/541 (28%), Positives = 246/541 (45%), Gaps = 60/541 (11%)
Query: 249 LHVASKRGNTNMV-KLLLDRGGQIDAKTRD-GLTPLHCAARSGHDQVVELLLERGAPLLA 306
LH A+ G ++ K+ D ++ + D G TPLHCA + V+ LL RGA
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD---YLTALHVAAHCGHYRVTKLL 363
R N ++PLH+A QG + E +K LL+H+ DV L+ TA+ +A + ++L
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHR--TIDVNLEGENGNTAVIIACTTNNSEALQIL 184
Query: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS--------IQAITESGLTPIH 415
L K A P G P+H A + ME+++++G I + TP+H
Sbjct: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
Query: 416 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA----LVDA 471
+A G L ++ + L NGA D TA+H AA G E+V+ ++ + + +V+
Sbjct: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
Query: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531
+T LH AS E+ L+ A + + G +PL ++ ++ ++LL
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
Query: 532 GAAHSLATKKGFTPLHVAAK--YGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYD 586
GA + G LH+ + YG ++ +Q + + +G TPLH A
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424
Query: 587 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK---QGVT 643
LL S H+ +K+ +PLH AA ++ LL ++T ++ + G+T
Sbjct: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
Query: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 703
PLHLA++ GH +V LLL KGA + +S +G T+LH A+
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMG------------------- 524
Query: 704 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 763
GYT + N+K + L ++G T LH AA++GH + +LL H
Sbjct: 525 ---GYTQTMKVILDTNLKCTDRL----------DEDGNTALHFAAREGHAKAVALLLSHN 571
Query: 764 A 764
A
Sbjct: 572 A 572
Score = 164 bits (416), Expect = 6e-40
Identities = 147/517 (28%), Positives = 233/517 (45%), Gaps = 55/517 (10%)
Query: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--------TALHVAAHCGHYRVTKLLLDK 366
LH AA +E ++ + + D +L+ L T LH A K LL +
Sbjct: 67 LHYAAAEGQIELMEKITR------DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 120
Query: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNI 425
ANPN R N PLHIA + +VM++L+++ + E+G T + +A +
Sbjct: 121 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 180
Query: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL--------VDARAREEQ 477
+ +LL+ GA P +N G +H AA +G E + +LR G ++ +
Sbjct: 181 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 240
Query: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA--GAAH 535
TPLH+A + G E++++ L + A D T +H +A +G ++ +++ + G+
Sbjct: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
Query: 536 SLATKKGF--TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593
+ T G T LH A+ + ++A L+ A + G +PL +A + + L
Sbjct: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
Query: 594 LLEKGASP-----------HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642
LL KGA H T + Y ++ + QMQ L+ E N G
Sbjct: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVM--DEDN----DGC 414
Query: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ-- 700
TPLH A ++G V LL +IH +K + LH AA ++N L + +D
Sbjct: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRL 474
Query: 701 ----DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHII 756
D H G TPL +A G+ K+V LLK+GA + NG+T LH A+ G+T +
Sbjct: 475 LNEGDLH---GMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
Query: 757 NVLLQHGAK-PNATTANGNTALAIAKRLGYISVVDTL 792
V+L K + +GNTAL A R G+ V L
Sbjct: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALL 567
Score = 149 bits (377), Expect = 2e-35
Identities = 131/488 (26%), Positives = 214/488 (43%), Gaps = 68/488 (13%)
Query: 381 LHIACKKNRIKVMELLVKYGASIQAITES---GLTPIHVAAFMGHLNIVLLLLQNGASPD 437
LH A + +I++ME + + +S++ + E G TP+H A + V LL GA+P+
Sbjct: 67 LHYAAAEGQIELMEKITR-DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPN 125
Query: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLL 496
+ N LH+A + EV++ LL + + V+ T + IA +E +Q+LL
Sbjct: 126 LRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILL 185
Query: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--------TPLHV 548
+ A P + G P+H +A G + ++L G H + + TPLH+
Sbjct: 186 KKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
Query: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK--GASPHATAK 606
A + G L++ K+ L A D K T +H AA ++ L++ G+
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
Query: 607 NGY--TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
+G T LH A+ + ++A L++ GA+ N + +G +PL LA+ ++V LLL KG
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
Query: 665 ANIHMSTKSGLTSLHLAAQED--------KVNVADILTKHGADQDAHTKLGYTPLIVACH 716
A + + G LHL Q+ + + + D+D G TPL AC
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDND---GCTPLHYACR 422
Query: 717 YGNVKMVNFLLKQGANVNAKTKN------------------------------------G 740
G VN LL ++++K+K+ G
Sbjct: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHG 482
Query: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800
TPLH AA+ GH ++ +LL+ GA + NG TAL A GY T+KV+ +
Sbjct: 483 MTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMGGY---TQTMKVILDTNL 538
Query: 801 TTTTTITE 808
T + E
Sbjct: 539 KCTDRLDE 546
Score = 140 bits (353), Expect = 1e-32
Identities = 129/464 (27%), Positives = 214/464 (46%), Gaps = 49/464 (10%)
Query: 34 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 93
ID+N +NG A+ +A + +Q LL +G+ + K G +H A+ +G E ++
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
Query: 94 VLVKEG--------ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
++++ G +IN + TPL++A Q ++++K L+NGA + T
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
Query: 146 LAVALQQGHNQAVAILLEN--------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197
+ A QG + V +++ + +T LH A+ D + A L+ A
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLI--SVGA 333
Query: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR-- 255
D +N+ G +PL +A + N+ LLL++GA VD G LH+ ++
Sbjct: 334 D------INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387
Query: 256 GNTNM----------VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
G N+ +L++D + DG TPLH A R G V LL +
Sbjct: 388 GLKNLRPEFMQMQQIKELVMD-------EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIH 440
Query: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAP---VDDVTLDYLTALHVAAHCGHYRVTKL 362
+++K+ SPLH AA + + LLQ + +++ L +T LH+AA GH +V +L
Sbjct: 441 SKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQL 500
Query: 363 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMG 421
LL K A NG+T LH A + M++++ + E G T +H AA G
Sbjct: 501 LLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559
Query: 422 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
H V LLL + A V N + + LH+A + EVV ++R+
Sbjct: 560 HAKAVALLLSHNAD-IVLNKQQASFLHLALHNKRKEVVLTIIRS 602
Score = 118 bits (295), Expect = 6e-26
Identities = 109/365 (29%), Positives = 166/365 (45%), Gaps = 49/365 (13%)
Query: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSA-TK 74
A + G+L+ + L G I+ + A+H AA +G +V+ ++ S SVD T
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
Query: 75 KG--NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
G T LH ASL E+ L+ GA+IN G +PL +A ++V LL G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
Query: 133 ANQSTATEDGFTPLAVALQQGH------------NQAVAILLENDTKGKVRLPALHIAAR 180
A G L + +QQ + Q ++++ D G LH A R
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDG---CTPLHYACR 422
Query: 181 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA---------TLL 231
+ S LL N + SK ++ +PLH AA YG +N T L
Sbjct: 423 QGGPGSVNNLL--GFNVSIHSK------SKDKKSPLHFAASYGRINTCQRLLQDISDTRL 474
Query: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 291
LN G +G+TPLH+A+K G+ +V+LLL +G + +G T LH A+ G+
Sbjct: 475 LNEGDL------HGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYT 527
Query: 292 QVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA--L 348
Q ++++L+ R ++G + LH AA+ H + V LL H A D+ L+ A L
Sbjct: 528 QTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA---DIVLNKQQASFL 584
Query: 349 HVAAH 353
H+A H
Sbjct: 585 HLALH 589
Score = 46.2 bits (108), Expect = 3e-04
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 7/118 (5%)
Query: 17 AARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSAT 73
AA+ G+ DKVV+ L KG + ++ + NG ALH A+ G+ ++ +L D
Sbjct: 489 AAKNGH-DKVVQLLLKKGALFLS--DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
Query: 74 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 131
+ GNTALH A+ G A+ V +L+ A+I Q + L++A +VV ++ +
Sbjct: 546 EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 179 bits (455), Expect = 2e-44
Identities = 109/326 (33%), Positives = 172/326 (52%), Gaps = 2/326 (0%)
Query: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
G + LH+A AGQ E + LL N A + R TPLH+A +V+LLL
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
+A + +T LH +A+ G +LLE A+ + +G TP+HVA ++G ++ ++LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
Query: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQM 621
+R GK+ PLH AA + + LL ++ G S +A +G TPLH+AA++
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
Query: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681
++A L++ ++ N+ + TPLH+A++ GHT LLL +GA T G T+LHLA
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
Query: 682 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 741
A+ + +L + AD A L T L +A +G+ ++V L+ ++ + G
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736
Query: 742 TPLHQAAQQGHTHIINVLLQHGAKPN 767
+ LH AAQ H + LL+HGA N
Sbjct: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 178 bits (451), Expect = 5e-44
Identities = 117/335 (34%), Positives = 176/335 (52%), Gaps = 3/335 (0%)
Query: 339 DVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 397
D+ LD + LH+A G K LL ANPN G TPLH+A ++ V+ELL+
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
Query: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457
S+ A E T +H AA G + LLL+ AS + + G T +H+A + GQ
Sbjct: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
Query: 458 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHIS 516
+VR LLR G V + ++ PLH A+ G IV+LL Q +A T +G TPLH++
Sbjct: 552 IVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 517 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
A+ G VA +L++ + ++ + TPLHVAA+ G A+LLL R A ++ +G
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
Query: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
T LH+AA + LL+E+ A A T LH+AA ++ L++ ++
Sbjct: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDL 730
Query: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST 671
+QG++ LHLA+Q H V LL GA+I++ +
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
Score = 172 bits (435), Expect = 4e-42
Identities = 115/345 (33%), Positives = 176/345 (51%), Gaps = 3/345 (0%)
Query: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315
G+T+ + +L + +D G + LH A +G ++ + LL A + G +PL
Sbjct: 417 GDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375
HMA + V+ LL K V+ D TALH AA G T+LLL+K A+ N
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
Query: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGA 434
G TP+H+AC+ + ++ +L++ G + + P+H AA+ GHL IV LL Q G
Sbjct: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
Query: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
S + + G T LH+AA+ G V R L+ + V+ + QTPLH+A+ G T +L
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
Query: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
LL A +A T++GYT LH++AR G + +L+E A T LH+AA +G
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
Query: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
+V + L+ D + GL+ LH+AA + + LL GA
Sbjct: 716 SEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 169 bits (427), Expect = 3e-41
Identities = 125/378 (33%), Positives = 196/378 (51%), Gaps = 17/378 (4%)
Query: 2 TTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 61
TT +QK + A +G+ K+++ L+ D++ +G + LHLA + G +
Sbjct: 402 TTDVQKK----KLVDAIVSGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKW 456
Query: 62 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
LL ++ + + ++G+T LH+A VV++L+ ++NA+ ++ +T L+ AAQ
Sbjct: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGD 516
Query: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHI 177
+ LLE A+ + +G TP+ VA Q G V ILL +GK LH
Sbjct: 517 ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHY 576
Query: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237
AA + LL + Q + VN T G TPLH+AA G+ VA +L++ +
Sbjct: 577 AAWQGHLPIVKLLAK-------QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
V+ + TPLHVA++ G+T+ +LLL RG +A T DG T LH AAR+GH V+LL
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689
Query: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
+E A +LAR + LH+AA H E V+ L+ +D L+ALH+AA H
Sbjct: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHA 748
Query: 358 RVTKLLLDKRANPNARAL 375
+ + LL A+ N ++L
Sbjct: 749 QTVETLLRHGAHINLQSL 766
Score = 168 bits (426), Expect = 4e-41
Identities = 116/358 (32%), Positives = 183/358 (51%), Gaps = 9/358 (2%)
Query: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
K+M++L + +SG + +H+A G LL N A+P+++N RG T LHMA
Sbjct: 421 KLMKILQPQ--DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
Query: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
VV LL V+A+ ++ T LH A++ G +LLL+ A + G
Sbjct: 479 VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR 538
Query: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
TP+H++ + GQ ++ +LL G SL K + PLH AA G L + KLL ++ + +
Sbjct: 539 TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVN 598
Query: 571 AGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
A +G TPLH+AA + +VA +L++ + + + TPLH+AA+ A LL+
Sbjct: 599 AQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH 658
Query: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689
GA +T G T LHLA++ GH V LL+++ A++ T+LHLAA V
Sbjct: 659 RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEV 718
Query: 690 ADILTKHGADQ-DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN---AKTKNGYTP 743
+ L AD D + G + L +A + + V LL+ GA++N K + G+ P
Sbjct: 719 VEELV--SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
Score = 157 bits (397), Expect = 9e-38
Identities = 103/330 (31%), Positives = 163/330 (49%), Gaps = 2/330 (0%)
Query: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
VD +G + LH+A + G K LL + R G TPLH A VVELL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
L R + A+ ++ + LH AAQ + LL+ A V++V + T +HVA G
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 358 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITESGLTPIHV 416
+ ++LL + + + + + + PLH A + + +++LL K G S+ A T G TP+H+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
AA GH + +L+ + +V ++ +T LH+AA G R LL GA +A +
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
T LH+A+R G V+LL++ A A T LH++A G +V L+ A
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-D 729
Query: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
L ++G + LH+AA+ + LL+ A
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 156 bits (395), Expect = 2e-37
Identities = 96/314 (30%), Positives = 160/314 (50%), Gaps = 2/314 (0%)
Query: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
LH+A G+ E + LL + A+P+ + G TPLH++ V +LL + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
+ +T LH AA+ G +LLL++ A+ + G TP+HVA + + + +LL +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 600 SPHATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVT 658
K+ + PLH AA + + I L G N T G TPLHLA+Q GH +
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 659 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 718
+L+D +++++ + T LH+AA+ + A +L GA ++A T GYT L +A G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
Query: 719 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 778
++ V L+++ A+V A+ T LH AA GH+ ++ L+ + G +AL
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
Query: 779 IAKRLGYISVVDTL 792
+A + + V+TL
Sbjct: 741 LAAQGRHAQTVETL 754
Score = 108 bits (269), Expect = 6e-23
Identities = 74/234 (31%), Positives = 116/234 (49%), Gaps = 3/234 (1%)
Query: 607 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
+G + LH+A + Q + A LL A N+ ++G TPLH+A + +V LLL + +
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
Query: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
++ + T+LH AAQ + +L + A + G TP+ VAC +G +V L
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 785
L++G +V+ + K+ + PLH AA QGH I+ +L Q G NA T +G T L +A + G+
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
Query: 786 ISVVDTLKVVTEEVTTTTTTI-TEKH-KLNVPETMTEVLDVSDEEGDDTMTGDG 837
V L + +V + T H T T L + G + MT DG
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Score = 70.5 bits (171), Expect = 1e-11
Identities = 44/160 (27%), Positives = 74/160 (46%)
Query: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
+ ++ G + LHLA + G + LL AN ++S + G T LH+A + V ++
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
L +A + +T L A G+ LL++ A+VN G TP+H A Q G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
+I+ +LL+ G + + L A G++ +V L
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 38.5 bits (88), Expect = 0.062
Identities = 24/72 (33%), Positives = 38/72 (52%)
Query: 4 MLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
+L + N + L A A +VVE L I+ ++ GL+ALHLAA+ H V+ LL
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
Query: 64 GRGSSVDSATKK 75
G+ ++ + K
Sbjct: 756 RHGAHINLQSLK 767
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 173 bits (438), Expect = 2e-42
Identities = 124/333 (37%), Positives = 166/333 (49%), Gaps = 11/333 (3%)
Query: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
G+ L A G + T LL +GA+V+ G TPLH+A RG+ +V+LLL RG +
Sbjct: 41 GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
Query: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 331
A R G T LH AA GH +V ELLL+RGA AR+ GL+PLH AA H LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
Query: 332 QHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 387
+ P + TA H AA G V +LL L+G L +A
Sbjct: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAAAA 213
Query: 388 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447
R + L+ GA + A +G T + +AA +G + +LL +GA P + + G +AL
Sbjct: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
Query: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
H AA G + V+ L+ GA VDAR TPLH ASR G E+ LL A DA
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
Query: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540
TPLH++A G +LL GA+ +L T+
Sbjct: 334 LRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
Score = 163 bits (412), Expect = 2e-39
Identities = 120/313 (38%), Positives = 161/313 (51%), Gaps = 11/313 (3%)
Query: 293 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 352
+V LL +GA + R G +PLH+A H V+ LLQ APV V TALH AA
Sbjct: 56 LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
Query: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNRIKVMELLVKYG---ASIQAITE 408
GH RV +LLL + A+ AR+ G TPLH A + + LL G A+ +A
Sbjct: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175
Query: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468
G T H AA G L ++ LL GA D AL +AA AG+ +R LL GA
Sbjct: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGAR 228
Query: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
VDAR T L +A+ LG+++ +++LL H A P +G + LH +A G + +L
Sbjct: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
Query: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
+ GA G TPLH A++ G ++VA LL R A D+ G TPLH+AA +
Sbjct: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
Query: 589 KVALLLLEKGASP 601
LLL +GASP
Sbjct: 349 PTVGLLLSRGASP 361
Score = 155 bits (392), Expect = 3e-37
Identities = 121/326 (37%), Positives = 161/326 (49%), Gaps = 11/326 (3%)
Query: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
A + G +V LL+ GAS + + G T LH+A G +VR LL+ GA V A R
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG---- 532
+T LH A+ G + + +LLLQ A A + G TPLH +A G +A+ LLEA
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
Query: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592
AA +G+T H AA G L V +LL AA AG +G L VAA
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGA--LLVAAAAGRGAALR 220
Query: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652
LL +GA A G T L +AA + Q LL +GA+ I + G + LH A+ G
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
Query: 653 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 712
H V LL+ +GA + GLT LH A++E V VA L GA DA L TPL
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
Query: 713 VACHYGNVKMVNFLLKQGANVNAKTK 738
+A G+ V LL +GA+ +T+
Sbjct: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
Score = 152 bits (383), Expect = 4e-36
Identities = 118/335 (35%), Positives = 160/335 (47%), Gaps = 15/335 (4%)
Query: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
G L A G GLV +LL +G+SV+ G T LH+A L G A +V++L++ GA +
Sbjct: 41 GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
Query: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
A + G T L+ AA H V + LL+ GA+ + + G TPL A GH A LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
Query: 163 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH----I 218
E G PA AA +D + H A ++ V +G L +
Sbjct: 161 EAPGPG----PA---AAEAEDARGWTAA----HWAAAGGRLAVLELLAAGGAGLDGALLV 209
Query: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
AA G LL RGA VD G T L +A+ G + +++LL G + R G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269
Query: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
+ LH AA GH V+LL+ +GA + AR GL+PLH A++ HVE LL A VD
Sbjct: 270 RSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVD 329
Query: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 373
T LH+AA GH LLL + A+P R
Sbjct: 330 ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
Score = 138 bits (348), Expect = 4e-32
Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 13/341 (3%)
Query: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546
G +V LL+ A + G TPLH++ G + +LL+ GA + G T L
Sbjct: 52 GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
Query: 547 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 606
H AA +G VA+LLLQR A+A + GLTPLH AA + +A LLE A A+
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
Query: 607 ----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
G+T H AA ++ + L GA + L +A+ G + LL
Sbjct: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLA 224
Query: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
+GA + +G T+L LAA + ++L HGAD + G + L A G++
Sbjct: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
Query: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782
V L+ QGA V+A+ G TPLH A+++GH + LL GA+ +AT T L +A
Sbjct: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
Query: 783 LGYISVVDTL--KVVTEEVTTTTTTITEKHKLNVPETMTEV 821
G+ V L + + + T + + + ++P+ + E+
Sbjct: 345 RGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPEL 385
Score = 124 bits (310), Expect = 1e-27
Identities = 113/349 (32%), Positives = 157/349 (44%), Gaps = 29/349 (8%)
Query: 109 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN---- 164
G+ L A +V LL GA+ G TPL +A+ +GH V +LL+
Sbjct: 41 GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
Query: 165 ---DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
D G+ ALH AA ++ A LLLQ +A +S +G TPLH AA
Sbjct: 101 GAVDRAGRT---ALHEAAWHGHSRVAELLLQRGASAAARSG--------TGLTPLHWAAA 149
Query: 222 YGNVNVATLLLNRG----AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277
G+ +A LL AA + G T H A+ G +++LL G +D
Sbjct: 150 LGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA--- 206
Query: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 337
L AA +G + LL RGA + AR G + L +AA + ++ LL H A
Sbjct: 207 ----LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262
Query: 338 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 397
+ALH AA GH +LL+ + A +AR G TPLH A ++ ++V L+
Sbjct: 263 GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
Query: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 446
GA + A TP+H+AA GH V LLL GASP + E A
Sbjct: 323 DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371
Score = 82.0 bits (201), Expect = 5e-15
Identities = 55/179 (30%), Positives = 86/179 (48%)
Query: 11 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
+ + L AA AG + L G ++ + G AL LAA G ++ LLG G+
Sbjct: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
Query: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
+ G +ALH A+ G V++LV +GA ++A+ G TPL+ A++E H++V LL+
Sbjct: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
Query: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 189
GA TPL +A ++GH V +LL +R +A + AL
Sbjct: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
Score = 72.4 bits (176), Expect = 4e-12
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 1/135 (0%)
Query: 7 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
+ + A+ L A A + +E L G G D +++G +ALH AA GH+ VQ L+ +
Sbjct: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
Query: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
G+ VD+ G T LH AS G EV L+ GA ++A TPL++AA+ H V
Sbjct: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
Query: 126 KYLLENGANQSTATE 140
LL GA+ + T+
Sbjct: 352 GLLLSRGASPTLRTQ 366
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 173 bits (438), Expect = 2e-42
Identities = 135/416 (32%), Positives = 204/416 (49%), Gaps = 24/416 (5%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA +
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 169 bits (429), Expect = 2e-41
Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)
Query: 37 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
Query: 97 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
Query: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215
V +LL + DHN E+G TP
Sbjct: 319 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 341
Query: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 273
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
Query: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
Query: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
Query: 453 AGQVEVVRCLLRNGALVD 470
G +V LL+ GA +D
Sbjct: 578 NGHTDVADVLLQAGADLD 595
Score = 168 bits (425), Expect = 5e-41
Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)
Query: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
A G+ N V+ LLD G ++ T +G + L A +G+ ++ ++LL A + R G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 312 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
++PL A+ G +++ VK LL H A V+ + TAL A G + K+LL++ AN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426
NG TPL A ++V +L+ +GA I ES LT +A + GHL++V
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 388
Query: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 545
G E+ LL++ A+ + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
L +A G +VA L++ A + TPL A+ + ++ LL GA+ HAT
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAE 633
G T L A + +A LL GA+
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGAD 593
Score = 141 bits (355), Expect = 7e-33
Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)
Query: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
N VD R+ E A G V+ LL + T G + L ++ G ++
Sbjct: 200 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
Query: 525 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
A VLL A K TPL A+ G LD+ KLLL A +S G T L A
Sbjct: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
Query: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 642
+ +LL +GA+ +NG+TPL AA +++A LL++GA N + +
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373
Query: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
+ L LA +GH DMV LL+ GA+ T T+L A + V VA +L GA +
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
+PL +A G+V++ L+++GAN+ GYTPL +AA++GH ++ +LL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 763 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 820
GA NA T TAL +A G+ V D L K + +T + E + E +
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
Query: 821 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872
+L T TGD Y ++ D L + LD ++ LEG
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 606
Score = 137 bits (344), Expect = 1e-31
Identities = 131/503 (26%), Positives = 218/503 (43%), Gaps = 71/503 (14%)
Query: 33 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92
G D+ T + L + +G + G+ + ++ +++ A A +
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191
Query: 93 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 152
++ + N Q L A + ++ V+ LL+ G + + TE+G + L +A
Sbjct: 192 RMKAENSHNAG---QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA 248
Query: 153 GHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESG 212
G+ + +LL A+H A+V+ +R +
Sbjct: 249 GYYELAQVLL-----------AMH--------------------ANVE-----DRGNKGD 272
Query: 213 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
TPL A+ G +++ LLL A V+ + G T L A G ++VK+LL+ G I+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 273 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLL 331
+G TPL AA +GH +V +LL+ GA + + S L +A H++ V+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 332 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 391
+ A + T + TAL A GH V +LLLD A N A + +PL +A ++
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV-TNIRGETALHMA 450
+ LL++ GA+++ + + G TP+ AA GH +V LLL GA+ + T ETAL +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 451 ------------------------------ARAGQVEVVRCLLRNGALVDARAREEQTPL 480
++ G +E+V+ LL +GA V A T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 481 HIASRLGKTEIVQLLLQHMAHPD 503
A G T++ +LLQ A D
Sbjct: 573 TYACENGHTDVADVLLQAGADLD 595
Score = 68.6 bits (166), Expect = 6e-11
Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
K N H + + SL A + VN L G + HT+ G + L +AC G ++
Sbjct: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
Query: 723 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
LL ANV + K TPL A+ G+ I+ +LL H A N+ +A GNTAL A
Sbjct: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
Query: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 840
G+ VD +KV+ E E H N + E E + G G
Sbjct: 314 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 365
Query: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 888
+ KE +L + + ++ +R+ LE G + +D HT
Sbjct: 366 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 407
Score = 51.6 bits (122), Expect = 7e-06
Identities = 35/102 (34%), Positives = 56/102 (54%), Gaps = 6/102 (5%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINT-CNQNGLNALHLAAKEGHVGLVQELL 63
Q ++ + L A G +V ++L K G DI C+ L A++EGH+ LV+ LL
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLL 555
Query: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
G++V + T G+TAL A G +V VL++ GA+++ Q
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 173 bits (438), Expect = 2e-42
Identities = 135/416 (32%), Positives = 204/416 (49%), Gaps = 24/416 (5%)
Query: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
Query: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298
Query: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
Query: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 359 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 410
Query: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
Query: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 527
Query: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA +
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
Score = 169 bits (429), Expect = 2e-41
Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)
Query: 37 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
Query: 97 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
Query: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215
V +LL + DHN E+G TP
Sbjct: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
Query: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 273
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
Query: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
Query: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
Query: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
Query: 453 AGQVEVVRCLLRNGALVD 470
G +V LL+ GA +D
Sbjct: 567 NGHTDVADVLLQAGADLD 584
Score = 168 bits (425), Expect = 5e-41
Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)
Query: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
A G+ N V+ LLD G ++ T +G + L A +G+ ++ ++LL A + R G
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 312 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
++PL A+ G +++ VK LL H A V+ + TAL A G + K+LL++ AN
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426
NG TPL A ++V +L+ +GA I ES LT +A + GHL++V
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
Query: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
Query: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 545
G E+ LL++ A+ + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
Query: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
L +A G +VA L++ A + TPL A+ + ++ LL GA+ HAT
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
Query: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAE 633
G T L A + +A LL GA+
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
Score = 160 bits (406), Expect = 8e-39
Identities = 119/388 (30%), Positives = 189/388 (48%), Gaps = 33/388 (8%)
Query: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
+L A G + LLD+ + N G + L +AC ++ ++L+ A+++
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 407 TESG-LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
G +TP+ A+ G+L+IV LLL + A + + G TAL A G V++V+ LL
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN-GYTPLHISAREGQVDV 524
GA ++ TPL A+ G E+ ++LL H A + + + L ++ +G +D+
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
Query: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
LLEAGA T + T L A G ++VA+LLL A + + +PL +AA
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
Query: 585 YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG--- 641
+ ++A LL+E+GA+ GYTPL AA++ ++ + LL GA N T++
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
Query: 642 ----------------------------VTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
TPL ASQEGH ++V LL GAN+H +T +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTAT 556
Query: 674 GLTSLHLAAQEDKVNVADILTKHGADQD 701
G T+L A + +VAD+L + GAD D
Sbjct: 557 GDTALTYACENGHTDVADVLLQAGADLD 584
Score = 141 bits (355), Expect = 7e-33
Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)
Query: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
N VD R+ E A G V+ LL + T G + L ++ G ++
Sbjct: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
Query: 525 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
A VLL A K TPL A+ G LD+ KLLL A +S G T L A
Sbjct: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
Query: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 642
+ +LL +GA+ +NG+TPL AA +++A LL++GA N + +
Sbjct: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
Query: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
+ L LA +GH DMV LL+ GA+ T T+L A + V VA +L GA +
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
+PL +A G+V++ L+++GAN+ GYTPL +AA++GH ++ +LL
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Query: 763 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 820
GA NA T TAL +A G+ V D L K + +T + E + E +
Sbjct: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
Query: 821 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872
+L T TGD Y ++ D L + LD ++ LEG
Sbjct: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
Score = 136 bits (342), Expect = 2e-31
Identities = 120/420 (28%), Positives = 191/420 (45%), Gaps = 68/420 (16%)
Query: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 175
A + ++ V+ LL+ G + + TE+G + L +A G+ + +LL A+
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-----------AM 249
Query: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235
H A+V+ +R + TPL A+ G +++ LLL
Sbjct: 250 H--------------------ANVE-----DRGNKGDITPLMAASSGGYLDIVKLLLLHD 284
Query: 236 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 295
A V+ + G T L A G ++VK+LL+ G I+ +G TPL AA +GH +V
Sbjct: 285 ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
Query: 296 LLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
+LL+ GA + + S L +A H++ V+ LL+ A + T + TAL A
Sbjct: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
Query: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
GH V +LLLD A N A + +PL +A +++ LL++ GA+++ + + G TP+
Sbjct: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 464
Query: 415 HVAAFMGHLNIVLLLLQNGASPDV-TNIRGETALHMA----------------------- 450
AA GH +V LLL GA+ + T ETAL +A
Sbjct: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 524
Query: 451 -------ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
++ G +E+V+ LL +GA V A T L A G T++ +LLQ A D
Sbjct: 525 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 68.6 bits (166), Expect = 6e-11
Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
K N H + + SL A + VN L G + HT+ G + L +AC G ++
Sbjct: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
Query: 723 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
LL ANV + K TPL A+ G+ I+ +LL H A N+ +A GNTAL A
Sbjct: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
Query: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 840
G+ VD +KV+ E E H N + E E + G G
Sbjct: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
Query: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 888
+ KE +L + + ++ +R+ LE G + +D HT
Sbjct: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
Score = 51.6 bits (122), Expect = 7e-06
Identities = 35/102 (34%), Positives = 56/102 (54%), Gaps = 6/102 (5%)
Query: 6 QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINT-CNQNGLNALHLAAKEGHVGLVQELL 63
Q ++ + L A G +V ++L K G DI C+ L A++EGH+ LV+ LL
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLL 544
Query: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
G++V + T G+TAL A G +V VL++ GA+++ Q
Sbjct: 545 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,256,977
Number of Sequences: 37866
Number of extensions: 3417346
Number of successful extensions: 28927
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 397
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 12355
Number of HSP's gapped (non-prelim): 6967
length of query: 1863
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1746
effective length of database: 13,817,196
effective search space: 24124824216
effective search space used: 24124824216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.