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Search of human proteins with 188219762
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188219762 denticleless homolog [Homo sapiens]
(730 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188219762 denticleless homolog [Homo sapiens] 1498 0.0
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 89 2e-17
gi|32189425 WD repeat domain 69 [Homo sapiens] 83 8e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 79 1e-14
gi|16554627 WD repeat domain 5 [Homo sapiens] 79 1e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 76 1e-13
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 70 5e-12
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 70 7e-12
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 70 7e-12
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 66 1e-10
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 65 2e-10
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 61 3e-09
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 61 3e-09
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 61 4e-09
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 61 4e-09
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 61 4e-09
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 60 9e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 58 4e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 58 4e-08
gi|4757988 WD repeat domain 39 [Homo sapiens] 57 5e-08
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 55 2e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 55 2e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 55 2e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 55 2e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 55 2e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 54 5e-07
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 54 7e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 53 9e-07
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 53 9e-07
gi|24041023 embryonic ectoderm development isoform b [Homo sapiens] 52 1e-06
>gi|188219762 denticleless homolog [Homo sapiens]
Length = 730
Score = 1498 bits (3877), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSA 60
MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSA
Sbjct: 1 MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSA 60
Query: 61 PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ 120
PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ
Sbjct: 61 PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ 120
Query: 121 TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR 180
TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR
Sbjct: 121 TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR 180
Query: 181 QVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII 240
QVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII
Sbjct: 181 QVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII 240
Query: 241 KVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNM 300
KVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNM
Sbjct: 241 KVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNM 300
Query: 301 TGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHS 360
TGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHS
Sbjct: 301 TGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHS 360
Query: 361 QEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGL 420
QEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGL
Sbjct: 361 QEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGL 420
Query: 421 VTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPI 480
VTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPI
Sbjct: 421 VTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPI 480
Query: 481 NRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQ 540
NRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQ
Sbjct: 481 NRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQ 540
Query: 541 AEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSK 600
AEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSK
Sbjct: 541 AEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSK 600
Query: 601 DSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENK 660
DSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENK
Sbjct: 601 DSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENK 660
Query: 661 NWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQED 720
NWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQED
Sbjct: 661 NWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQED 720
Query: 721 FCGPEHSTEL 730
FCGPEHSTEL
Sbjct: 721 FCGPEHSTEL 730
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 88.6 bits (218), Expect = 2e-17
Identities = 79/319 (24%), Positives = 122/319 (38%), Gaps = 55/319 (17%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
LA A + + L+N K H AV +L + L +A+ D+T WD
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLK---GHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137
Query: 127 VKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQIS 186
+ GE + KGH + S ++ + CTG DG + +WD R
Sbjct: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR--------------- 182
Query: 187 GAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLR 246
K + V V F D + + +G +D IKVWDLR
Sbjct: 183 -------------------KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223
Query: 247 KNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGL--K 304
+N Y A + L L S GS L +N D+ + ++++ K
Sbjct: 224 QNKLTYTMRGHAD-------------SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270
Query: 305 TSPVAIFNG--HQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQE 362
V IF G H ++ S SPD + +GS+D Y+W +T + L GH+
Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD-TTSRRILYKLPGHAGS 329
Query: 363 VTSVCWCPSDFTKIATCSD 381
+ V + P + I+ SD
Sbjct: 330 INEVAFHPDEPIIISASSD 348
Score = 37.0 bits (84), Expect = 0.065
Identities = 30/110 (27%), Positives = 48/110 (43%), Gaps = 4/110 (3%)
Query: 283 GSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAY 342
GSTL + D I ++N+ G A GH + ++ + D L S S+D+
Sbjct: 78 GSTLASAGFDRLILLWNVYG-DCDNYATLKGHSGAV--MELHYNTDGSMLFSASTDKTVA 134
Query: 343 IWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNR 392
+W T + L GH+ V S + T SDD T+K+W + +
Sbjct: 135 VWDSETGERVKR-LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 83.2 bits (204), Expect = 8e-16
Identities = 79/305 (25%), Positives = 125/305 (40%), Gaps = 61/305 (20%)
Query: 89 KCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAF 148
KC+ + H + L++ P + T + D TAK WD++ GE + T +GH + S++F
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 149 SKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKG 208
+ + TG D ++VWD +K VN + G
Sbjct: 228 NTSGDRII-TGSFDHTVVVWDADTGRK------VNILIG--------------------- 259
Query: 209 LAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSS 268
++ F + +L+ G++D K+WD A + +A+ +
Sbjct: 260 ------HCAEISSASFNWDCSLILTGSMDKTCKLWD------ATNGKCVATLT------- 300
Query: 269 TRKLGYSSLILDS----TGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSS 324
G+ ILDS TG + D +F+ K +A GH+ K S
Sbjct: 301 ----GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC--IAKLEGHEGE--ISKIS 352
Query: 325 LSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNT 384
+P L++GSSD+ A IW T Q VL GH+ E+ S C + T S DNT
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQT-GQCLQVLEGHTDEIFS-CAFNYKGNIVITGSKDNT 410
Query: 385 LKIWR 389
+IWR
Sbjct: 411 CRIWR 415
Score = 53.1 bits (126), Expect = 9e-07
Identities = 25/103 (24%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
++A A+ +G R+++ + +KC + H + +++ P L+T + D+TA+ W
Sbjct: 317 LIATASADGTARIFSAAT----RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVW 168
D + G+ + +GH + S AF+ ++ + TG +D +W
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414
Score = 39.7 bits (91), Expect = 0.010
Identities = 31/134 (23%), Positives = 58/134 (43%), Gaps = 5/134 (3%)
Query: 262 FLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYV 321
+L+ L +++ L+ +GS D +++ + GH+N + +
Sbjct: 83 YLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTAS--GEELNTLEGHRNVVYAI 140
Query: 322 KSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSD 381
+ +P + +GS D+ +W V T T GH+ E+ + + P T +AT S
Sbjct: 141 AFN-NPYGDKIATGSFDKTCKLWSVETGKCYHT-FRGHTAEIVCLSFNPQS-TLVATGSM 197
Query: 382 DNTLKIWRLNRGLE 395
D T K+W + G E
Sbjct: 198 DTTAKLWDIQNGEE 211
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 79.0 bits (193), Expect = 1e-14
Identities = 73/332 (21%), Positives = 135/332 (40%), Gaps = 56/332 (16%)
Query: 60 APNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGD 119
+PN E LA ++ + ++++ F K H + D+AW LV+A+ D
Sbjct: 54 SPNGEW-LASSSADKLIKIWGAYDGKFEKTI----SGHKLGISDVAWSSDSNLLVSASDD 108
Query: 120 QTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFY 179
+T K WDV +G+ + T KGH + F+ + + +G D ++ +WD + K
Sbjct: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGK----- 162
Query: 180 RQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGI 239
K P+ V+ V F + +L+ + + DG+
Sbjct: 163 ------------CLKTLPA----------------HSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 240 IKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFN 299
++WD AS L S + G + A D+ + +++
Sbjct: 195 CRIWD------------TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 300 MTGLKTSPVAIFNGHQNSTFYVKSSLS-PDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLG 358
+ K + + GH+N + + ++ S +++VSGS D YIW + T + L G
Sbjct: 243 YS--KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQG 299
Query: 359 HSQEVTSVCWCPSD-FTKIATCSDDNTLKIWR 389
H+ V S P++ A +D T+K+W+
Sbjct: 300 HTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSD 372
GH + VK SP+ ++L S S+D+ IW T+ GH ++ V W SD
Sbjct: 43 GHTKAVSSVK--FSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWS-SD 98
Query: 373 FTKIATCSDDNTLKIWRLNRG 393
+ + SDD TLKIW ++ G
Sbjct: 99 SNLLVSASDDKTLKIWDVSSG 119
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 79.0 bits (193), Expect = 1e-14
Identities = 73/332 (21%), Positives = 135/332 (40%), Gaps = 56/332 (16%)
Query: 60 APNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGD 119
+PN E LA ++ + ++++ F K H + D+AW LV+A+ D
Sbjct: 54 SPNGEW-LASSSADKLIKIWGAYDGKFEKTI----SGHKLGISDVAWSSDSNLLVSASDD 108
Query: 120 QTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFY 179
+T K WDV +G+ + T KGH + F+ + + +G D ++ +WD + K
Sbjct: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGK----- 162
Query: 180 RQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGI 239
K P+ V+ V F + +L+ + + DG+
Sbjct: 163 ------------CLKTLPA----------------HSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 240 IKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFN 299
++WD AS L S + G + A D+ + +++
Sbjct: 195 CRIWD------------TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 300 MTGLKTSPVAIFNGHQNSTFYVKSSLS-PDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLG 358
+ K + + GH+N + + ++ S +++VSGS D YIW + T + L G
Sbjct: 243 YS--KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQG 299
Query: 359 HSQEVTSVCWCPSD-FTKIATCSDDNTLKIWR 389
H+ V S P++ A +D T+K+W+
Sbjct: 300 HTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSD 372
GH + VK SP+ ++L S S+D+ IW T+ GH ++ V W SD
Sbjct: 43 GHTKAVSSVK--FSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWS-SD 98
Query: 373 FTKIATCSDDNTLKIWRLNRG 393
+ + SDD TLKIW ++ G
Sbjct: 99 SNLLVSASDDKTLKIWDVSSG 119
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 75.9 bits (185), Expect = 1e-13
Identities = 71/334 (21%), Positives = 135/334 (40%), Gaps = 56/334 (16%)
Query: 60 APNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGD 119
+PN E LA ++ + + ++ + K + H + D+AW +LV+A+ D
Sbjct: 50 SPNGEW-LASSSADRLIIIWGAYDGKYEKTLY----GHNLEISDVAWSSDSSRLVSASDD 104
Query: 120 QTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFY 179
+T K WDV++G+ + T KGH + F+ + +G D + +W+ + K
Sbjct: 105 KTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII-SGSFDETVKIWEVKTGK----- 158
Query: 180 RQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGI 239
+ AH+ V+ V F +L+ +G+ DG+
Sbjct: 159 --CLKTLSAHS--------------------------DPVSAVHFNCSGSLIVSGSYDGL 190
Query: 240 IKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFN 299
++WD AS L S + G + D+ + +++
Sbjct: 191 CRIWD------------AASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 300 MTGLKTSPVAIFNGHQNSTFYVKSSLS-PDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLG 358
+ + + + GH+N + + ++ S +++VSGS D YIW + T + L G
Sbjct: 239 YS--RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQG 295
Query: 359 HSQEVTSVCWCPSD-FTKIATCSDDNTLKIWRLN 391
H+ V S P++ A +D T+K+W N
Sbjct: 296 HTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 50.4 bits (119), Expect = 6e-06
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 4/81 (4%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSD 372
GH + VK SP+ ++L S S+D IW T L GH+ E++ V W SD
Sbjct: 39 GHTEAVSSVK--FSPNGEWLASSSADRLIIIWGAYDGKYEKT-LYGHNLEISDVAWS-SD 94
Query: 373 FTKIATCSDDNTLKIWRLNRG 393
+++ + SDD TLK+W + G
Sbjct: 95 SSRLVSASDDKTLKLWDVRSG 115
Score = 38.1 bits (87), Expect = 0.029
Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 30/207 (14%)
Query: 185 ISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVW- 243
+S + N S K+ P P N V ++V+ V F +++ + D +I +W
Sbjct: 15 LSSSANQS-KEVPENP----NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG 69
Query: 244 --DLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMT 301
D + T Y L S + S S L + D + ++++
Sbjct: 70 AYDGKYEKTLYGHN----------------LEISDVAWSSDSSRLVSASDDKTLKLWDVR 113
Query: 302 GLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQ 361
K + GH N F + +P ++SGS DE IW+V T T L HS
Sbjct: 114 SGKC--LKTLKGHSNYVFCC--NFNPPSNLIISGSFDETVKIWEVKTGKCLKT-LSAHSD 168
Query: 362 EVTSVCWCPSDFTKIATCSDDNTLKIW 388
V++V + S + I + S D +IW
Sbjct: 169 PVSAVHFNCSG-SLIVSGSYDGLCRIW 194
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 70.5 bits (171), Expect = 5e-12
Identities = 68/331 (20%), Positives = 128/331 (38%), Gaps = 53/331 (16%)
Query: 61 PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ 120
P H+L + + ++L+ + ++C + ++ H AV D+ + + ++AA D+
Sbjct: 298 PLSGHLLLSCSMDCKIKLWEVYGE---RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDR 354
Query: 121 TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFE--KAVFCTGGRDGNIMVWDTRCNKKDGF 178
K WD + G+ I + V F+ E + +F G D I+ WD R +
Sbjct: 355 YLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---I 410
Query: 179 YRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDG 238
++ ++ GA NT ++F DEN + + D
Sbjct: 411 VQEYDRHLGAVNT------------------------------IVFVDENRRFVSTSDDK 440
Query: 239 IIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMF 298
++VW+ P+ K P + ++ L G L D+ I +F
Sbjct: 441 SLRVWEW--------DIPVDFKYIAEPSMHSMP----AVTLSPNGKWLACQSMDNQILIF 488
Query: 299 NMTG-LKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLL 357
+ + IF GH + + + SPD +++SG + IW T + +
Sbjct: 489 GAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT-KLYSRFK 547
Query: 358 GHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
H + W P + +K+ TC D +K+W
Sbjct: 548 AHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578
Score = 30.8 bits (68), Expect = 4.7
Identities = 23/92 (25%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 303 LKTSPVAIFNGHQNSTFYVKSSLSP-DDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQ 361
L + +++GH V+ L P L+S S D +W+V + +GHS+
Sbjct: 276 LPKKQIHVWSGHTKGVSAVR--LFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK 333
Query: 362 EVTSVCWCPSDFTKIATCSDDNTLKIWRLNRG 393
V +C+ + T+ + + D LK+W G
Sbjct: 334 AVRDICFNTAG-TQFLSAAYDRYLKLWDTETG 364
Score = 30.8 bits (68), Expect = 4.7
Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 1/83 (1%)
Query: 87 RKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 146
+KK FK M A + + P +++ G+ WD K +L K H
Sbjct: 498 KKKIFKGHMVAGYAC-QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGA 556
Query: 147 AFSKFEKAVFCTGGRDGNIMVWD 169
+ E + T G DG I +WD
Sbjct: 557 VWHPHETSKVITCGWDGLIKLWD 579
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 70.1 bits (170), Expect = 7e-12
Identities = 63/249 (25%), Positives = 104/249 (41%), Gaps = 49/249 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKA-V 155
H N + ++ +++++TA+GD T WDV++G+L+ + GH + + + E
Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT 211
Query: 156 FCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDF 215
F +GG D MVWD R Q Q H
Sbjct: 212 FVSGGCDKKAMVWDMRSG-------QCVQAFETH-------------------------- 238
Query: 216 QQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYS 275
+ + V + ++G+ D +++DLR A R+ I SK + G S
Sbjct: 239 ESDINSVRYYPSGDAFASGSDDATCRLYDLR----ADREVAIYSKESII-------FGAS 287
Query: 276 SLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSG 335
S+ +G LFA D I ++++ LK S V+I GH+N ++ +SPD SG
Sbjct: 288 SVDFSLSGRLLFAGYNDYTINVWDV--LKGSRVSILFGHENRVSTLR--VSPDGTAFCSG 343
Query: 336 SSDEAAYIW 344
S D +W
Sbjct: 344 SWDHTLRVW 352
Score = 31.2 bits (69), Expect = 3.6
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 311 FNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370
F+GH + + S VSG D+ A +W + + Q H ++ SV + P
Sbjct: 191 FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS-GQCVQAFETHESDINSVRYYP 249
Query: 371 SDFTKIATCSDDNTLKIWRLNRGLE 395
S A+ SDD T +++ L E
Sbjct: 250 SG-DAFASGSDDATCRLYDLRADRE 273
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 70.1 bits (170), Expect = 7e-12
Identities = 63/249 (25%), Positives = 104/249 (41%), Gaps = 49/249 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKA-V 155
H N + ++ +++++TA+GD T WDV++G+L+ + GH + + + E
Sbjct: 194 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT 253
Query: 156 FCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDF 215
F +GG D MVWD R Q Q H
Sbjct: 254 FVSGGCDKKAMVWDMRSG-------QCVQAFETH-------------------------- 280
Query: 216 QQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYS 275
+ + V + ++G+ D +++DLR A R+ I SK + G S
Sbjct: 281 ESDINSVRYYPSGDAFASGSDDATCRLYDLR----ADREVAIYSKESII-------FGAS 329
Query: 276 SLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSG 335
S+ +G LFA D I ++++ LK S V+I GH+N ++ +SPD SG
Sbjct: 330 SVDFSLSGRLLFAGYNDYTINVWDV--LKGSRVSILFGHENRVSTLR--VSPDGTAFCSG 385
Query: 336 SSDEAAYIW 344
S D +W
Sbjct: 386 SWDHTLRVW 394
Score = 31.2 bits (69), Expect = 3.6
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 311 FNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370
F+GH + + S VSG D+ A +W + + Q H ++ SV + P
Sbjct: 233 FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS-GQCVQAFETHESDINSVRYYP 291
Query: 371 SDFTKIATCSDDNTLKIWRLNRGLE 395
S A+ SDD T +++ L E
Sbjct: 292 SG-DAFASGSDDATCRLYDLRADRE 315
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 66.2 bits (160), Expect = 1e-10
Identities = 91/370 (24%), Positives = 149/370 (40%), Gaps = 64/370 (17%)
Query: 43 YGETGVPVPPFGCTF-----SSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAH 97
Y E P C F SS E + + + R+++ E +S + H
Sbjct: 85 YVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKSIMTI-----VGH 139
Query: 98 WNAVFDLAWVPGE---LKLVTAAGDQTAKFWD-------VKAGELIGTCKGHQCSLKSVA 147
+ V D+AWV + L++A+ DQT W+ VKA + C+GH S+ S+A
Sbjct: 140 TDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKA---LHCCRGHAGSVDSIA 196
Query: 148 FSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSK 207
FC+G D + +W T + +++ ++P+KKQ ++
Sbjct: 197 VDG-SGTKFCSGSWDKMLKIWST--------------VPTDEEDEMEESTNRPRKKQKTE 241
Query: 208 GLA----PSVDFQ---QSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASK 260
L P V ++V+ VL+ D + SA + D I+VWD+ + K
Sbjct: 242 QLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSA-SWDHTIRVWDVESG---------SLK 291
Query: 261 SFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAI-FNGHQNSTF 319
S L + YS L L + TD +I +++ S V++ H
Sbjct: 292 STLTGNKVFNCISYSPLC-----KRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
Query: 320 YVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATC 379
VK S + + Q L+SGS D +W + P L H +V SV W +D + +
Sbjct: 347 SVKWSPTHEQQ-LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDW--TDTGLLLSG 403
Query: 380 SDDNTLKIWR 389
DN L +R
Sbjct: 404 GADNKLYSYR 413
Score = 34.3 bits (77), Expect = 0.42
Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 2/42 (4%)
Query: 352 PPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRG 393
P L GH + V+SV W SD +I + S D+T+++W + G
Sbjct: 249 PIVTLSGHMEAVSSVLW--SDAEEICSASWDHTIRVWDVESG 288
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 65.1 bits (157), Expect = 2e-10
Identities = 83/378 (21%), Positives = 144/378 (38%), Gaps = 54/378 (14%)
Query: 89 KCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAF 148
+C H AV +A+ P L + +GD T +FWD+ TCKGH+ + S+++
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 149 SKFEKAVFCTGGRDGNIMVWDTRCNKKDG--FYRQVNQISGAHNTSDKQTPSKPKKKQNS 206
S + +G ++G I++WD K+ G I+G P +S
Sbjct: 165 SP-DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
Query: 207 KGLAPSV-------------DFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRK------ 247
K + + QSVT + + + L SA + D IKVW
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSA-SQDRTIKVWRAHDGVLCRT 282
Query: 248 --------NYTAYRQEPIASKSFLYPGSST---------------RKLGYSSLILDSTGS 284
N A + P ++ R L +L+
Sbjct: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE 342
Query: 285 TLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIW 344
L + D +++++ K P+ GHQ + SPD + + S S D++ +W
Sbjct: 343 RLVSGSDDFTLFLWSPAEDK-KPLTRMTGHQ--ALINQVLFSPDSRIVASASFDKSIKLW 399
Query: 345 KVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW--RLNRGLEEKPG-GD 401
T + L GH V + W +D + + S D+TLK+W + + + PG D
Sbjct: 400 DGRT-GKYLASLRGHVAAVYQIAW-SADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 457
Query: 402 KLSTVGWASQKKKESRPG 419
++ V W+ ++ + G
Sbjct: 458 EVYAVDWSPDGQRVASGG 475
Score = 58.2 bits (139), Expect = 3e-08
Identities = 81/327 (24%), Positives = 131/327 (40%), Gaps = 65/327 (19%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
+A ++++G VR+++T + +C + H +V L W G+ L +A+ D+T K W
Sbjct: 219 VASSSKDGSVRIWDTTAG----RCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIKVWR 273
Query: 127 VKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQIS 186
G L T +GH G N M T + G +
Sbjct: 274 AHDGVLCRTLQGH--------------------GHWVNTMALSTDYALRTGAFEPAE--- 310
Query: 187 GAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLR 246
+ N D Q + K++ +V Q LVS
Sbjct: 311 ASVNPQDLQGSLQELKERALS----------RYNLVRGQGPERLVSGS------------ 348
Query: 247 KNYTAYRQEPIASKSFLYPGSSTRKLGYSSLI---LDSTGSTLFANCT-DDNIYMFNMTG 302
++T + P K L TR G+ +LI L S S + A+ + D +I +++ G
Sbjct: 349 DDFTLFLWSPAEDKKPL-----TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--G 401
Query: 303 LKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQE 362
+A GH + + + + S D + LVSGSSD +W V + L GH+ E
Sbjct: 402 RTGKYLASLRGHVAAVYQI--AWSADSRLLVSGSSDSTLKVWDVKAQ-KLAMDLPGHADE 458
Query: 363 VTSVCWCPSDFTKIATCSDDNTLKIWR 389
V +V W P D ++A+ D L+IWR
Sbjct: 459 VYAVDWSP-DGQRVASGGKDKCLRIWR 484
Score = 40.8 bits (94), Expect = 0.005
Identities = 35/125 (28%), Positives = 54/125 (43%), Gaps = 14/125 (11%)
Query: 278 ILDSTGSTLFANCTD-----DNIY----MFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPD 328
I+ S G TL + + D IY +F + + T + GH + V + SP
Sbjct: 69 IVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAV-TRCTSSLEGHSEAVISV--AFSPT 125
Query: 329 DQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
++L SGS D W +ST P GH V S+ W P D K+A+ + + +W
Sbjct: 126 GKYLASGSGDTTVRFWDLSTE-TPHFTCKGHRHWVLSISWSP-DGRKLASGCKNGQILLW 183
Query: 389 RLNRG 393
+ G
Sbjct: 184 DPSTG 188
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 61.2 bits (147), Expect = 3e-09
Identities = 65/247 (26%), Positives = 103/247 (41%), Gaps = 41/247 (16%)
Query: 114 VTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTR-- 171
+T D+T K W+ G L+ T GH + A S F+ + C+GG D +++WD
Sbjct: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS-FDNSSLCSGGGDKAVVLWDVASG 99
Query: 172 --CNKKDGFYRQVNQI----------SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSV 219
K G +VN + SG+ ++S + + ++ + + L + D SV
Sbjct: 100 QVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV 159
Query: 220 TVVLFQDENTLVSAGAVDGIIKVWDLRKN--YTAYRQEPIASKSFLYPGSSTRKLGYSSL 277
V D L AG+VDG ++ +DLR ++ Y PI F G T
Sbjct: 160 KV---SDHEIL--AGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCT-------- 206
Query: 278 ILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSS 337
++ S STL D TG + + GH+N + + LS D +VS S
Sbjct: 207 LVSSLDSTLRLLDKD--------TG---ELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
Query: 338 DEAAYIW 344
D + W
Sbjct: 256 DGKVFFW 262
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 61.2 bits (147), Expect = 3e-09
Identities = 65/247 (26%), Positives = 103/247 (41%), Gaps = 41/247 (16%)
Query: 114 VTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTR-- 171
+T D+T K W+ G L+ T GH + A S F+ + C+GG D +++WD
Sbjct: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS-FDNSSLCSGGGDKAVVLWDVASG 99
Query: 172 --CNKKDGFYRQVNQI----------SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSV 219
K G +VN + SG+ ++S + + ++ + + L + D SV
Sbjct: 100 QVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV 159
Query: 220 TVVLFQDENTLVSAGAVDGIIKVWDLRKN--YTAYRQEPIASKSFLYPGSSTRKLGYSSL 277
V D L AG+VDG ++ +DLR ++ Y PI F G T
Sbjct: 160 KV---SDHEIL--AGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCT-------- 206
Query: 278 ILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSS 337
++ S STL D TG + + GH+N + + LS D +VS S
Sbjct: 207 LVSSLDSTLRLLDKD--------TG---ELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
Query: 338 DEAAYIW 344
D + W
Sbjct: 256 DGKVFFW 262
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 60.8 bits (146), Expect = 4e-09
Identities = 75/329 (22%), Positives = 126/329 (38%), Gaps = 77/329 (23%)
Query: 87 RKKCFKEWM----------AHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTC 136
+K+ KEW+ H + V + + P +V+A+ D T K WD + G+ T
Sbjct: 87 QKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL 146
Query: 137 KGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQT 196
KGH S++ ++F K + + D I +WD + GF HN S
Sbjct: 147 KGHTDSVQDISFDHSGK-LLASCSADMTIKLWDFQ-----GFECIRTMHGHDHNVS---- 196
Query: 197 PSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEP 256
+V + + + +VSA D IK+W+++ Y
Sbjct: 197 -----------------------SVAIMPNGDHIVSASR-DKTIKMWEVQTGYCV----- 227
Query: 257 IASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKT----------- 305
K+F T + ++ + TL A+C++D + K
Sbjct: 228 ---KTF------TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 306 ------SPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGH 359
+P + ++ +T FL+SGS D+ +W VST T L+GH
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT-LVGH 337
Query: 360 SQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
V V + S I +C+DD TL++W
Sbjct: 338 DNWVRGVLF-HSGGKFILSCADDKTLRVW 365
Score = 38.1 bits (87), Expect = 0.029
Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 54/179 (30%)
Query: 88 KKCFKEWMAHWNAVFDLAWVP------------GELK--------LVTAAGDQTAKFWDV 127
K+C E H + V ++W P E K L++ + D+T K WDV
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325
Query: 128 KAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISG 187
G + T GH ++ V F K + D + VWD + NK+ +
Sbjct: 326 STGMCLMTLVGHDNWVRGVLFHSGGKFILSCAD-DKTLRVWDYK-NKR------CMKTLN 377
Query: 188 AHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLR 246
AH + S+DF ++ V+ G+VD +KVW+ R
Sbjct: 378 AH-----------------EHFVTSLDFHKTAPYVV---------TGSVDQTVKVWECR 410
Score = 30.0 bits (66), Expect = 8.0
Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 4/81 (4%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSD 372
GH +S + S + L S S+D +W ++ + GH V+SV P+
Sbjct: 148 GHTDSVQDI--SFDHSGKLLASCSADMTIKLWDFQG-FECIRTMHGHDHNVSSVAIMPNG 204
Query: 373 FTKIATCSDDNTLKIWRLNRG 393
I + S D T+K+W + G
Sbjct: 205 -DHIVSASRDKTIKMWEVQTG 224
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 60.8 bits (146), Expect = 4e-09
Identities = 79/337 (23%), Positives = 129/337 (38%), Gaps = 59/337 (17%)
Query: 55 CTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLV 114
C FS N LA +++ V ++ + + K K H V +AW P + LV
Sbjct: 198 CKFS---NDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLV 254
Query: 115 TAAGDQTAKFW--DVKAGEL-IGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTR 171
D ++ W +V+ GEL + H+ SL SVA++ K F TGG+ G D
Sbjct: 255 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR-FVTGGQRGQFYQCDLD 313
Query: 172 CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLV 231
N D + + ++ SD +T Q +G +F+ + Q+++ ++
Sbjct: 314 GNLLDSW--EGVRVQCLWCLSDGKTVLASDTHQRIRGY----NFEDLTDRNIVQEDHPIM 367
Query: 232 SAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT 291
S +T + +A + G L L+ G T
Sbjct: 368 S----------------FTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVT------ 405
Query: 292 DDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQ 351
Y + + F GH ++ F+ SGS D YIW +
Sbjct: 406 -QGFYTIH---------SCFGGH-------------NEDFIASGSEDHKVYIWHKRSEL- 441
Query: 352 PPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
P L GH++ V V W P + +A+ SDD T++IW
Sbjct: 442 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/118 (27%), Positives = 48/118 (40%), Gaps = 20/118 (16%)
Query: 310 IFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLL-------GHSQE 362
I H N ++ K S D L +GS D IW+V P T LL GH+
Sbjct: 187 ILTEHCNEVWFCK--FSNDGTKLATGSKDTTVIIWQVD----PDTHLLKLLKTLEGHAYG 240
Query: 363 VTSVCWCPSDFTKIATCSDDNTLKIWRLN------RGLEEKPGGDKLSTVGWASQKKK 414
V+ + W P D + C D+ ++W N R + D L++V W K+
Sbjct: 241 VSYIAWSPDD-NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR 297
>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
Length = 514
Score = 60.8 bits (146), Expect = 4e-09
Identities = 79/337 (23%), Positives = 129/337 (38%), Gaps = 59/337 (17%)
Query: 55 CTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLV 114
C FS N LA +++ V ++ + + K K H V +AW P + LV
Sbjct: 214 CKFS---NDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLV 270
Query: 115 TAAGDQTAKFW--DVKAGEL-IGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTR 171
D ++ W +V+ GEL + H+ SL SVA++ K F TGG+ G D
Sbjct: 271 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR-FVTGGQRGQFYQCDLD 329
Query: 172 CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLV 231
N D + + ++ SD +T Q +G +F+ + Q+++ ++
Sbjct: 330 GNLLDSW--EGVRVQCLWCLSDGKTVLASDTHQRIRGY----NFEDLTDRNIVQEDHPIM 383
Query: 232 SAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT 291
S +T + +A + G L L+ G T
Sbjct: 384 S----------------FTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVT------ 421
Query: 292 DDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQ 351
Y + + F GH ++ F+ SGS D YIW +
Sbjct: 422 -QGFYTIH---------SCFGGH-------------NEDFIASGSEDHKVYIWHKRSEL- 457
Query: 352 PPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
P L GH++ V V W P + +A+ SDD T++IW
Sbjct: 458 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/118 (27%), Positives = 48/118 (40%), Gaps = 20/118 (16%)
Query: 310 IFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLL-------GHSQE 362
I H N ++ K S D L +GS D IW+V P T LL GH+
Sbjct: 203 ILTEHCNEVWFCK--FSNDGTKLATGSKDTTVIIWQVD----PDTHLLKLLKTLEGHAYG 256
Query: 363 VTSVCWCPSDFTKIATCSDDNTLKIWRLN------RGLEEKPGGDKLSTVGWASQKKK 414
V+ + W P D + C D+ ++W N R + D L++V W K+
Sbjct: 257 VSYIAWSPDD-NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR 313
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 59.7 bits (143), Expect = 9e-09
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)
Query: 53 FGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAW--VPGE 110
F T+S N EHVL + +G ++L++T + + +KE H V+ + W GE
Sbjct: 71 FDVTWSE--NNEHVLITCSGDGSLQLWDTAKAAGPLQVYKE---HAQEVYSVDWSQTRGE 125
Query: 111 LKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDT 170
+V+ + DQT K WD G+ + T +GH+ + S +S F + D + +WD
Sbjct: 126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
Query: 171 R 171
+
Sbjct: 186 K 186
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 1/99 (1%)
Query: 290 CTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTP 349
C+ D T P+ ++ H + V S + +Q +VSGS D+ +W T
Sbjct: 86 CSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD-PTV 144
Query: 350 WQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
+ GH + S W P A+ S D TL+IW
Sbjct: 145 GKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIW 183
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 97 HWNAVFDLAW---VPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEK 153
H + ++ W +PG +A+GDQT + WDVKA + HQ + S + K+ +
Sbjct: 154 HESIIYSTIWSPHIPG--CFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNE 211
Query: 154 AVFCTGGRDGNIMVWDTR 171
+ TG D ++ WD R
Sbjct: 212 NLLVTGAVDCSLRGWDLR 229
Score = 41.6 bits (96), Expect = 0.003
Identities = 66/297 (22%), Positives = 112/297 (37%), Gaps = 59/297 (19%)
Query: 106 WVPGELKLVTA-----AGDQTAKFWDV-KAGELIGTCKGHQCSLKSVAFSKFEKAVFCTG 159
++PG L TA AG T D +AG + L V +S+ + V T
Sbjct: 27 YLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITC 86
Query: 160 GRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSV 219
DG++ +WDT K K++++ + SVD+ Q+
Sbjct: 87 SGDGSLQLWDTA----------------------KAAGPLQVYKEHAQEVY-SVDWSQT- 122
Query: 220 TVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLIL 279
LV +G+ D +K+WD P KS G+ S+I
Sbjct: 123 ------RGEQLVVSGSWDQTVKLWD-----------PTVGKSLC------TFRGHESIIY 159
Query: 280 DSTGST----LFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSG 335
+ S FA+ + D + +K + V I + ++ LV+G
Sbjct: 160 STIWSPHIPGCFASASGDQT--LRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTG 217
Query: 336 SSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNR 392
+ D + W + QP LLGH+ + V + P + +A+CS D T++ W ++
Sbjct: 218 AVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
Score = 32.3 bits (72), Expect = 1.6
Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 6/112 (5%)
Query: 60 APNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVP-GELKLVTAAG 118
+P++ A A+ + +R+++ ++ R AH + W E LVT A
Sbjct: 164 SPHIPGCFASASGDQTLRIWDVKAAGVRIVI----PAHQAEILSCDWCKYNENLLVTGAV 219
Query: 119 DQTAKFWDVK-AGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWD 169
D + + WD++ + + GH +++ V FS F +V + D + W+
Sbjct: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWN 271
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/149 (28%), Positives = 70/149 (46%), Gaps = 18/149 (12%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
+A A + V++++ + + + + H AV L++ P L+TA+ D T K D
Sbjct: 164 IAAAGMDNTVKVWDVRTH----RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Query: 127 VKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQIS 186
+ G L+ T GHQ +VAFS+ + F +GG D +MVW + + D + +V ++
Sbjct: 220 LMEGRLLYTLHGHQGPATTVAFSRTGE-YFASGGSDEQVMVWKSNFDIVD--HGEVTKV- 275
Query: 187 GAHNTSDKQTPSKPKKKQNSKGLAPSVDF 215
P P +S G P VDF
Sbjct: 276 ----------PRPPATLASSMGNLPEVDF 294
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 311 FNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370
F GH+++ V + SP L SGS D+ IW + + TV H+ V SV +C
Sbjct: 19 FTGHKDAVTCV--NFSPSGHLLASGSRDKTVRIWVPNVKGES-TVFRAHTATVRSVHFC- 74
Query: 371 SDFTKIATCSDDNTLKIWRLNR 392
SD T SDD T+K+W +R
Sbjct: 75 SDGQSFVTASDDKTVKVWATHR 96
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/259 (21%), Positives = 100/259 (38%), Gaps = 29/259 (11%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H +AV + + P L + + D+T + W + H +++SV F ++ F
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS-F 80
Query: 157 CTGGRDGNIMVWDTRCNK-KDGFYRQVNQISGAH---------NTSDKQTPSKPKKKQNS 206
T D + VW T K + +N + A + SD +T K K +
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV-KLWDKSSR 139
Query: 207 KGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPG 266
+ + + VT V F T ++A +D +KVWD+R + L
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR-------------LLQH 186
Query: 267 SSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLS 326
+ L +G+ L +D + + ++ ++ + +GHQ V + S
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQGPATTV--AFS 242
Query: 327 PDDQFLVSGSSDEAAYIWK 345
++ SG SDE +WK
Sbjct: 243 RTGEYFASGGSDEQVMVWK 261
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 23/175 (13%)
Query: 216 QQSVTVVLFQDENTLVSAGAVDGIIKVW--DLRKNYTAYRQEPIASKSFLYPGSSTRKLG 273
+ +VT V F L+++G+ D +++W +++ T +R +S +
Sbjct: 23 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG----- 77
Query: 274 YSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLV 333
S + S T+ T ++F+++ Q+ + + SPD + +V
Sbjct: 78 -QSFVTASDDKTVKVWATHRQKFLFSLS-------------QHINWVRCAKFSPDGRLIV 123
Query: 334 SGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
S S D+ +W S+ + H VT V + PS T IA DNT+K+W
Sbjct: 124 SASDDKTVKLWDKSSR-ECVHSYCEHGGFVTYVDFHPSG-TCIAAAGMDNTVKVW 176
Score = 36.6 bits (83), Expect = 0.085
Identities = 41/183 (22%), Positives = 70/183 (38%), Gaps = 14/183 (7%)
Query: 70 ANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKA 129
A+++ V+++ T Q F + H N V + P +V+A+ D+T K WD +
Sbjct: 83 ASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138
Query: 130 GELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR----QVNQI 185
E + + H + V F + G D + VWD R ++ Y+ VN +
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCI-AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGL 197
Query: 186 SGAHN-----TSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII 240
S + T+ + K + L Q T V F ++G D +
Sbjct: 198 SFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 257
Query: 241 KVW 243
VW
Sbjct: 258 MVW 260
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/149 (28%), Positives = 70/149 (46%), Gaps = 18/149 (12%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
+A A + V++++ + + + + H AV L++ P L+TA+ D T K D
Sbjct: 202 IAAAGMDNTVKVWDVRTH----RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Query: 127 VKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQIS 186
+ G L+ T GHQ +VAFS+ + F +GG D +MVW + + D + +V ++
Sbjct: 258 LMEGRLLYTLHGHQGPATTVAFSRTGE-YFASGGSDEQVMVWKSNFDIVD--HGEVTKV- 313
Query: 187 GAHNTSDKQTPSKPKKKQNSKGLAPSVDF 215
P P +S G P VDF
Sbjct: 314 ----------PRPPATLASSMGNLPEVDF 332
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 311 FNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370
F GH+++ V + SP L SGS D+ IW + + TV H+ V SV +C
Sbjct: 57 FTGHKDAVTCV--NFSPSGHLLASGSRDKTVRIWVPNVKGES-TVFRAHTATVRSVHFC- 112
Query: 371 SDFTKIATCSDDNTLKIWRLNR 392
SD T SDD T+K+W +R
Sbjct: 113 SDGQSFVTASDDKTVKVWATHR 134
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/259 (21%), Positives = 100/259 (38%), Gaps = 29/259 (11%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H +AV + + P L + + D+T + W + H +++SV F ++ F
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS-F 118
Query: 157 CTGGRDGNIMVWDTRCNK-KDGFYRQVNQISGAH---------NTSDKQTPSKPKKKQNS 206
T D + VW T K + +N + A + SD +T K K +
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV-KLWDKSSR 177
Query: 207 KGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPG 266
+ + + VT V F T ++A +D +KVWD+R + L
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR-------------LLQH 224
Query: 267 SSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLS 326
+ L +G+ L +D + + ++ ++ + +GHQ V + S
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQGPATTV--AFS 280
Query: 327 PDDQFLVSGSSDEAAYIWK 345
++ SG SDE +WK
Sbjct: 281 RTGEYFASGGSDEQVMVWK 299
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 23/175 (13%)
Query: 216 QQSVTVVLFQDENTLVSAGAVDGIIKVW--DLRKNYTAYRQEPIASKSFLYPGSSTRKLG 273
+ +VT V F L+++G+ D +++W +++ T +R +S +
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG----- 115
Query: 274 YSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLV 333
S + S T+ T ++F+++ Q+ + + SPD + +V
Sbjct: 116 -QSFVTASDDKTVKVWATHRQKFLFSLS-------------QHINWVRCAKFSPDGRLIV 161
Query: 334 SGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
S S D+ +W S+ + H VT V + PS T IA DNT+K+W
Sbjct: 162 SASDDKTVKLWDKSSR-ECVHSYCEHGGFVTYVDFHPSG-TCIAAAGMDNTVKVW 214
Score = 36.6 bits (83), Expect = 0.085
Identities = 41/183 (22%), Positives = 70/183 (38%), Gaps = 14/183 (7%)
Query: 70 ANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKA 129
A+++ V+++ T Q F + H N V + P +V+A+ D+T K WD +
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 130 GELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR----QVNQI 185
E + + H + V F + G D + VWD R ++ Y+ VN +
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCI-AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGL 235
Query: 186 SGAHN-----TSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII 240
S + T+ + K + L Q T V F ++G D +
Sbjct: 236 SFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 241 KVW 243
VW
Sbjct: 296 MVW 298
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 57.4 bits (137), Expect = 5e-08
Identities = 81/366 (22%), Positives = 136/366 (37%), Gaps = 69/366 (18%)
Query: 51 PPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGE 110
P C F + +LA + +R++ TE S+ K H V +AW P
Sbjct: 15 PDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCG 73
Query: 111 LKLVTAAGDQTAKFWDVKAG--ELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVW 168
L +A+ D T W E + T +GH+ +KSVA++ + T RD ++ VW
Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVW 132
Query: 169 DTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDEN 228
+ +++D + + + +H K P S+ L S + +V + ++++
Sbjct: 133 EV--DEEDEY--ECVSVLNSHTQDVKHVVWHP-----SQELLASASYDDTVKLYREEEDD 183
Query: 229 TLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFA 288
+ A VW SL D +G L A
Sbjct: 184 WVCCATLEGHESTVW--------------------------------SLAFDPSGQRL-A 210
Query: 289 NCTDDNIYMF-------NMTGLKTSP-------VAIFNGHQNSTFYVKSSLSPDDQFLVS 334
+C+DD N G+ S + +G + T Y + L +
Sbjct: 211 SCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA-LAT 269
Query: 335 GSSDEAAYIWKV---STPWQPPTVLLGH-----SQEVTSVCWCPSDFTKIATCSDDNTLK 386
D+A +++ S P QP L H SQ+V V W P + +A+CSDD +
Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVA 329
Query: 387 IWRLNR 392
W+ R
Sbjct: 330 FWKYQR 335
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/349 (22%), Positives = 137/349 (39%), Gaps = 50/349 (14%)
Query: 89 KCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAF 148
K ++ H V +A PG VT + D+T K WD+ +G+L + GH +++ V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 149 SKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR-QVNQISG--AHNTSD------KQTPSK 199
S +F + G D + WD NK Y ++ + G H T D + + ++
Sbjct: 255 STRSPYLF-SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 200 PKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIAS 259
+ + +V V Q + G+ D I++WDL +A
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL-----------VAG 362
Query: 260 KSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQN--S 317
K+ + + K +++L T FA+ + DNI + S + +GH +
Sbjct: 363 KTRV--TLTNHKKSVRAVVLHPRHYT-FASGSPDNIKQWKFP--DGSFIQNLSGHNAIIN 417
Query: 318 TFYVKSSLSPDDQFLVSGSSDEAAYIW---------KVSTPWQPPTVLLGHSQEVTSVCW 368
T V S D LVSG+ + ++W +V QP ++ S+ C
Sbjct: 418 TLTVNS-----DGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSL---DSESGIFACA 469
Query: 369 CPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESR 417
+++ T D T+K++R E+ ++ V W + K R
Sbjct: 470 FDQSESRLLTAEADKTIKVYR-----EDDTATEETHPVSWKPEIIKRKR 513
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 55.1 bits (131), Expect = 2e-07
Identities = 75/313 (23%), Positives = 115/313 (36%), Gaps = 62/313 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H + VF AW P L + +GD TA+ W++ G+ Q L+ E
Sbjct: 180 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST---QLVLRHCIR---EGGHD 233
Query: 157 CTGGRDGNIMVWDTR-----CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAP 211
+D + W+T DGF R + +T + K N KG
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG--- 290
Query: 212 SVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRK 271
N ++SAG VD +WD A +Q P S
Sbjct: 291 ----------------NYILSAG-VDKTTIIWDAHTG-EAKQQFPFHSAP---------- 322
Query: 272 LGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQF 331
+L +D +T FA+C+ D G PV F GH N +K P
Sbjct: 323 ----ALDVDWQNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAIK--WDPSGML 375
Query: 332 LVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCPS--------DFTKIATCSD 381
L S S D IW + Q + L H++E+ ++ W P+ +A+ S
Sbjct: 376 LASCSDDMTLKIWSMK---QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 382 DNTLKIWRLNRGL 394
D+T+++W + RG+
Sbjct: 433 DSTVRLWDIERGV 445
Score = 46.6 bits (109), Expect = 8e-05
Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 30/222 (13%)
Query: 213 VDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTA---YRQEPIASKSFLYPGSST 269
V + VT + + TL++ G+ DG ++W N + + PI + + G+
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 293
Query: 270 RKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDD 329
G +D T + ++ T + F ++P + N+TF
Sbjct: 294 LSAG-----VDKT-TIIWDAHTGEAKQQFPF---HSAPALDVDWQNNTTF---------- 334
Query: 330 QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWR 389
S S+D ++ ++ +P GH+ EV ++ W PS +A+CSDD TLKIW
Sbjct: 335 ---ASCSTDMCIHVCRLGCD-RPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWS 389
Query: 390 LNRGL---EEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQS 428
+ + + + + ++ T+ W+ S P + +S S
Sbjct: 390 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/172 (21%), Positives = 58/172 (33%), Gaps = 16/172 (9%)
Query: 92 KEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKF 151
K + H N V + W P + L + + D T K W +K I + H + ++ +S
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 152 EKA--------VFCTGGRDGNIMVWD--------TRCNKKDGFYRQVNQISGAHNTSDKQ 195
A + + D + +WD T ++ Y G + S
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 196 TPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRK 247
S L S + V + V A A DG + V DLRK
Sbjct: 475 DKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 36.6 bits (83), Expect = 0.085
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 18/93 (19%)
Query: 309 AIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCW 368
A NG +N V + P + + G +V P TVL GH EV W
Sbjct: 142 ATVNGEENRAHSVNNHAKPME---IDG---------EVEIPSSKATVLRGHESEVFICAW 189
Query: 369 CP-SDFTKIATCSDDNTLKIWRLNRGLEEKPGG 400
P SD +A+ S D+T +IW LN E GG
Sbjct: 190 NPVSDL--LASGSGDSTARIWNLN---ENSNGG 217
Score = 33.9 bits (76), Expect = 0.55
Identities = 60/309 (19%), Positives = 109/309 (35%), Gaps = 62/309 (20%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
+LA + +GF R++ TE + + H +F L W +++A D+T W
Sbjct: 251 LLATGSYDGFARIW-TEDGNLASTLGQ----HKGPIFALKWNRKGNYILSAGVDKTTIIW 305
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQI 185
D GE H V + F + D I V C+ R V
Sbjct: 306 DAHTGEAKQQFPFHSAPALDVDWQN--NTTFASCSTDMCIHVCRLGCD------RPVKTF 357
Query: 186 SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDL 245
G N V + + L+++ + D +K+W +
Sbjct: 358 QGHTN---------------------------EVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Query: 246 RKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT-DDNIYMFNMT-GL 303
++ + + + + S T + + + A+ + D + ++++ G+
Sbjct: 391 KQEVCIHDLQAHNKEIYTIKWSPT-----GPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 304 KTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEV 363
T + HQ + V + SPD ++L SGS D+ +IW + L HS
Sbjct: 446 CTHTLT---KHQEPVYSV--AFSPDGKYLASGSFDKCVHIWNTQSG------NLVHSYRG 494
Query: 364 T----SVCW 368
T VCW
Sbjct: 495 TGGIFEVCW 503
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 55.1 bits (131), Expect = 2e-07
Identities = 75/313 (23%), Positives = 115/313 (36%), Gaps = 62/313 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H + VF AW P L + +GD TA+ W++ G+ Q L+ E
Sbjct: 180 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST---QLVLRHCIR---EGGHD 233
Query: 157 CTGGRDGNIMVWDTR-----CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAP 211
+D + W+T DGF R + +T + K N KG
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG--- 290
Query: 212 SVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRK 271
N ++SAG VD +WD A +Q P S
Sbjct: 291 ----------------NYILSAG-VDKTTIIWDAHTG-EAKQQFPFHSAP---------- 322
Query: 272 LGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQF 331
+L +D +T FA+C+ D G PV F GH N +K P
Sbjct: 323 ----ALDVDWQNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAIK--WDPSGML 375
Query: 332 LVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCPS--------DFTKIATCSD 381
L S S D IW + Q + L H++E+ ++ W P+ +A+ S
Sbjct: 376 LASCSDDMTLKIWSMK---QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 382 DNTLKIWRLNRGL 394
D+T+++W + RG+
Sbjct: 433 DSTVRLWDIERGV 445
Score = 46.6 bits (109), Expect = 8e-05
Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 30/222 (13%)
Query: 213 VDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTA---YRQEPIASKSFLYPGSST 269
V + VT + + TL++ G+ DG ++W N + + PI + + G+
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 293
Query: 270 RKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDD 329
G +D T + ++ T + F ++P + N+TF
Sbjct: 294 LSAG-----VDKT-TIIWDAHTGEAKQQFPF---HSAPALDVDWQNNTTF---------- 334
Query: 330 QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWR 389
S S+D ++ ++ +P GH+ EV ++ W PS +A+CSDD TLKIW
Sbjct: 335 ---ASCSTDMCIHVCRLGCD-RPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWS 389
Query: 390 LNRGL---EEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQS 428
+ + + + + ++ T+ W+ S P + +S S
Sbjct: 390 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/172 (21%), Positives = 58/172 (33%), Gaps = 16/172 (9%)
Query: 92 KEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKF 151
K + H N V + W P + L + + D T K W +K I + H + ++ +S
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 152 EKA--------VFCTGGRDGNIMVWD--------TRCNKKDGFYRQVNQISGAHNTSDKQ 195
A + + D + +WD T ++ Y G + S
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 196 TPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRK 247
S L S + V + V A A DG + V DLRK
Sbjct: 475 DKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 36.6 bits (83), Expect = 0.085
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 18/93 (19%)
Query: 309 AIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCW 368
A NG +N V + P + + G +V P TVL GH EV W
Sbjct: 142 ATVNGEENRAHSVNNHAKPME---IDG---------EVEIPSSKATVLRGHESEVFICAW 189
Query: 369 CP-SDFTKIATCSDDNTLKIWRLNRGLEEKPGG 400
P SD +A+ S D+T +IW LN E GG
Sbjct: 190 NPVSDL--LASGSGDSTARIWNLN---ENSNGG 217
Score = 33.9 bits (76), Expect = 0.55
Identities = 60/309 (19%), Positives = 109/309 (35%), Gaps = 62/309 (20%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
+LA + +GF R++ TE + + H +F L W +++A D+T W
Sbjct: 251 LLATGSYDGFARIW-TEDGNLASTLGQ----HKGPIFALKWNRKGNYILSAGVDKTTIIW 305
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQI 185
D GE H V + F + D I V C+ R V
Sbjct: 306 DAHTGEAKQQFPFHSAPALDVDWQN--NTTFASCSTDMCIHVCRLGCD------RPVKTF 357
Query: 186 SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDL 245
G N V + + L+++ + D +K+W +
Sbjct: 358 QGHTN---------------------------EVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Query: 246 RKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT-DDNIYMFNMT-GL 303
++ + + + + S T + + + A+ + D + ++++ G+
Sbjct: 391 KQEVCIHDLQAHNKEIYTIKWSPT-----GPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 304 KTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEV 363
T + HQ + V + SPD ++L SGS D+ +IW + L HS
Sbjct: 446 CTHTLT---KHQEPVYSV--AFSPDGKYLASGSFDKCVHIWNTQSG------NLVHSYRG 494
Query: 364 T----SVCW 368
T VCW
Sbjct: 495 TGGIFEVCW 503
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 55.1 bits (131), Expect = 2e-07
Identities = 75/313 (23%), Positives = 115/313 (36%), Gaps = 62/313 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H + VF AW P L + +GD TA+ W++ G+ Q L+ E
Sbjct: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST---QLVLRHCIR---EGGHD 284
Query: 157 CTGGRDGNIMVWDTR-----CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAP 211
+D + W+T DGF R + +T + K N KG
Sbjct: 285 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG--- 341
Query: 212 SVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRK 271
N ++SAG VD +WD A +Q P S
Sbjct: 342 ----------------NYILSAG-VDKTTIIWDAHTG-EAKQQFPFHSAP---------- 373
Query: 272 LGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQF 331
+L +D +T FA+C+ D G PV F GH N +K P
Sbjct: 374 ----ALDVDWQNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAIK--WDPSGML 426
Query: 332 LVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCPS--------DFTKIATCSD 381
L S S D IW + Q + L H++E+ ++ W P+ +A+ S
Sbjct: 427 LASCSDDMTLKIWSMK---QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 382 DNTLKIWRLNRGL 394
D+T+++W + RG+
Sbjct: 484 DSTVRLWDIERGV 496
Score = 46.6 bits (109), Expect = 8e-05
Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 30/222 (13%)
Query: 213 VDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTA---YRQEPIASKSFLYPGSST 269
V + VT + + TL++ G+ DG ++W N + + PI + + G+
Sbjct: 285 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 344
Query: 270 RKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDD 329
G +D T + ++ T + F ++P + N+TF
Sbjct: 345 LSAG-----VDKT-TIIWDAHTGEAKQQFPF---HSAPALDVDWQNNTTF---------- 385
Query: 330 QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWR 389
S S+D ++ ++ +P GH+ EV ++ W PS +A+CSDD TLKIW
Sbjct: 386 ---ASCSTDMCIHVCRLGCD-RPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWS 440
Query: 390 LNRGL---EEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQS 428
+ + + + + ++ T+ W+ S P + +S S
Sbjct: 441 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/172 (21%), Positives = 58/172 (33%), Gaps = 16/172 (9%)
Query: 92 KEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKF 151
K + H N V + W P + L + + D T K W +K I + H + ++ +S
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 152 EKA--------VFCTGGRDGNIMVWD--------TRCNKKDGFYRQVNQISGAHNTSDKQ 195
A + + D + +WD T ++ Y G + S
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 196 TPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRK 247
S L S + V + V A A DG + V DLRK
Sbjct: 526 DKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 36.6 bits (83), Expect = 0.085
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 18/93 (19%)
Query: 309 AIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCW 368
A NG +N V + P + + G +V P TVL GH EV W
Sbjct: 193 ATVNGEENRAHSVNNHAKPME---IDG---------EVEIPSSKATVLRGHESEVFICAW 240
Query: 369 CP-SDFTKIATCSDDNTLKIWRLNRGLEEKPGG 400
P SD +A+ S D+T +IW LN E GG
Sbjct: 241 NPVSDL--LASGSGDSTARIWNLN---ENSNGG 268
Score = 33.9 bits (76), Expect = 0.55
Identities = 60/309 (19%), Positives = 109/309 (35%), Gaps = 62/309 (20%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
+LA + +GF R++ TE + + H +F L W +++A D+T W
Sbjct: 302 LLATGSYDGFARIW-TEDGNLASTLGQ----HKGPIFALKWNRKGNYILSAGVDKTTIIW 356
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQI 185
D GE H V + F + D I V C+ R V
Sbjct: 357 DAHTGEAKQQFPFHSAPALDVDWQN--NTTFASCSTDMCIHVCRLGCD------RPVKTF 408
Query: 186 SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDL 245
G N V + + L+++ + D +K+W +
Sbjct: 409 QGHTN---------------------------EVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Query: 246 RKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT-DDNIYMFNMT-GL 303
++ + + + + S T + + + A+ + D + ++++ G+
Sbjct: 442 KQEVCIHDLQAHNKEIYTIKWSPT-----GPATSNPNSNIMLASASFDSTVRLWDIERGV 496
Query: 304 KTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEV 363
T + HQ + V + SPD ++L SGS D+ +IW + L HS
Sbjct: 497 CTHTLT---KHQEPVYSV--AFSPDGKYLASGSFDKCVHIWNTQSG------NLVHSYRG 545
Query: 364 T----SVCW 368
T VCW
Sbjct: 546 TGGIFEVCW 554
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 55.1 bits (131), Expect = 2e-07
Identities = 75/313 (23%), Positives = 115/313 (36%), Gaps = 62/313 (19%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H + VF AW P L + +GD TA+ W++ G+ Q L+ E
Sbjct: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST---QLVLRHCIR---EGGHD 284
Query: 157 CTGGRDGNIMVWDTR-----CNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAP 211
+D + W+T DGF R + +T + K N KG
Sbjct: 285 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG--- 341
Query: 212 SVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRK 271
N ++SAG VD +WD A +Q P S
Sbjct: 342 ----------------NYILSAG-VDKTTIIWDAHTG-EAKQQFPFHSAP---------- 373
Query: 272 LGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQF 331
+L +D +T FA+C+ D G PV F GH N +K P
Sbjct: 374 ----ALDVDWQNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAIK--WDPSGML 426
Query: 332 LVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCPS--------DFTKIATCSD 381
L S S D IW + Q + L H++E+ ++ W P+ +A+ S
Sbjct: 427 LASCSDDMTLKIWSMK---QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 382 DNTLKIWRLNRGL 394
D+T+++W + RG+
Sbjct: 484 DSTVRLWDIERGV 496
Score = 46.6 bits (109), Expect = 8e-05
Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 30/222 (13%)
Query: 213 VDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTA---YRQEPIASKSFLYPGSST 269
V + VT + + TL++ G+ DG ++W N + + PI + + G+
Sbjct: 285 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 344
Query: 270 RKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDD 329
G +D T + ++ T + F ++P + N+TF
Sbjct: 345 LSAG-----VDKT-TIIWDAHTGEAKQQFPF---HSAPALDVDWQNNTTF---------- 385
Query: 330 QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWR 389
S S+D ++ ++ +P GH+ EV ++ W PS +A+CSDD TLKIW
Sbjct: 386 ---ASCSTDMCIHVCRLGCD-RPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWS 440
Query: 390 LNRGL---EEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQS 428
+ + + + + ++ T+ W+ S P + +S S
Sbjct: 441 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/172 (21%), Positives = 58/172 (33%), Gaps = 16/172 (9%)
Query: 92 KEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKF 151
K + H N V + W P + L + + D T K W +K I + H + ++ +S
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 152 EKA--------VFCTGGRDGNIMVWD--------TRCNKKDGFYRQVNQISGAHNTSDKQ 195
A + + D + +WD T ++ Y G + S
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 196 TPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRK 247
S L S + V + V A A DG + V DLRK
Sbjct: 526 DKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 36.6 bits (83), Expect = 0.085
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 18/93 (19%)
Query: 309 AIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCW 368
A NG +N V + P + + G +V P TVL GH EV W
Sbjct: 193 ATVNGEENRAHSVNNHAKPME---IDG---------EVEIPSSKATVLRGHESEVFICAW 240
Query: 369 CP-SDFTKIATCSDDNTLKIWRLNRGLEEKPGG 400
P SD +A+ S D+T +IW LN E GG
Sbjct: 241 NPVSDL--LASGSGDSTARIWNLN---ENSNGG 268
Score = 33.9 bits (76), Expect = 0.55
Identities = 60/309 (19%), Positives = 109/309 (35%), Gaps = 62/309 (20%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
+LA + +GF R++ TE + + H +F L W +++A D+T W
Sbjct: 302 LLATGSYDGFARIW-TEDGNLASTLGQ----HKGPIFALKWNRKGNYILSAGVDKTTIIW 356
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQI 185
D GE H V + F + D I V C+ R V
Sbjct: 357 DAHTGEAKQQFPFHSAPALDVDWQN--NTTFASCSTDMCIHVCRLGCD------RPVKTF 408
Query: 186 SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDL 245
G N V + + L+++ + D +K+W +
Sbjct: 409 QGHTN---------------------------EVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Query: 246 RKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCT-DDNIYMFNMT-GL 303
++ + + + + S T + + + A+ + D + ++++ G+
Sbjct: 442 KQEVCIHDLQAHNKEIYTIKWSPT-----GPATSNPNSNIMLASASFDSTVRLWDIERGV 496
Query: 304 KTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEV 363
T + HQ + V + SPD ++L SGS D+ +IW + L HS
Sbjct: 497 CTHTLT---KHQEPVYSV--AFSPDGKYLASGSFDKCVHIWNTQSG------NLVHSYRG 545
Query: 364 T----SVCW 368
T VCW
Sbjct: 546 TGGIFEVCW 554
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 53.9 bits (128), Expect = 5e-07
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 15/130 (11%)
Query: 44 GETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFD 103
G TG P C FS H+ A A+ + VRL++ R KC + H +V
Sbjct: 61 GHTG---PVKFCRFSPDG---HLFASASCDCTVRLWDVA----RAKCLRVLKGHQRSVET 110
Query: 104 LAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFC--TGGR 161
+++ P +L + D+ WDV++G+++ GH+ S++S S F V C TG
Sbjct: 111 VSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSW 167
Query: 162 DGNIMVWDTR 171
D + +WD R
Sbjct: 168 DSTVHIWDLR 177
Score = 50.8 bits (120), Expect = 4e-06
Identities = 62/263 (23%), Positives = 108/263 (41%), Gaps = 29/263 (11%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H V A+ P L+T + D W+ ++G+L+ GH +K FS + +F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP-DGHLF 78
Query: 157 CTGGRDGNIMVWDTRCNK----KDGFYRQVNQISGAHNTSDKQTPSKPKK-----KQNSK 207
+ D + +WD K G R V +S + ++ + K+ Q+ +
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 208 GLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGS 267
L V + S+ F ++ G+ D + +WDLR A + + S +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHS-----A 193
Query: 268 STRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAI-FNGHQNSTFYVKS-SL 325
+ L YS+ L ++GS D I+++ T TS + I GH +VKS +
Sbjct: 194 NISCLCYSASGLLASGS------WDKTIHIWKPT---TSSLLIQLKGH---VTWVKSIAF 241
Query: 326 SPDDQFLVSGSSDEAAYIWKVST 348
SPD+ +L S +W +T
Sbjct: 242 SPDELWLASAGYSRMVKVWDCNT 264
Score = 40.4 bits (93), Expect = 0.006
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIW--KVSTPWQPPTVLLGHSQEVTSVCWCP 370
GH++S S SP L +GS D +IW ++ TP L GHS ++ +C+
Sbjct: 145 GHRDSI--QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202
Query: 371 SDFTKIATCSDDNTLKIWR 389
S +A+ S D T+ IW+
Sbjct: 203 SGL--LASGSWDKTIHIWK 219
Score = 34.7 bits (78), Expect = 0.32
Identities = 24/73 (32%), Positives = 36/73 (49%), Gaps = 8/73 (10%)
Query: 323 SSLSPDDQFLVSGSSDEAAYIWKVSTP---WQPPTVLLGHSQEVTSVCWCPSDFTKIATC 379
S+ SPD Q L++GS D Y W+ + W+ L GH+ V C D A+
Sbjct: 27 SAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR----LGGHTGPV-KFCRFSPDGHLFASA 81
Query: 380 SDDNTLKIWRLNR 392
S D T+++W + R
Sbjct: 82 SCDCTVRLWDVAR 94
Score = 33.1 bits (74), Expect = 0.94
Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 1/62 (1%)
Query: 113 LVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRC 172
L + + D+T W L+ KGH +KS+AFS ++ + G + VWD
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWDCNT 264
Query: 173 NK 174
K
Sbjct: 265 GK 266
Score = 30.8 bits (68), Expect = 4.7
Identities = 17/51 (33%), Positives = 24/51 (47%), Gaps = 5/51 (9%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKG-----HQCS 142
H V +A+ P EL L +A + K WD G+ + T KG H C+
Sbjct: 232 HVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCA 282
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 53.5 bits (127), Expect = 7e-07
Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 5/102 (4%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
+A A + V++++ + + + + H AV L++ P L+TA+ D T K D
Sbjct: 202 IAAAGMDNTVKVWDVRTH----RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Query: 127 VKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVW 168
+ G L+ T GHQ +VAFS+ + F +GG D +MVW
Sbjct: 258 LMEGRLLYTLHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 298
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 311 FNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370
F GH+++ V + SP L SGS D+ IW + + TV H+ V SV +C
Sbjct: 57 FTGHKDAVTCV--NFSPSGHLLASGSRDKTVRIWVPNVKGES-TVFRAHTATVRSVHFC- 112
Query: 371 SDFTKIATCSDDNTLKIWRLNR 392
SD T SDD T+K+W +R
Sbjct: 113 SDGQSFVTASDDKTVKVWATHR 134
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/259 (21%), Positives = 100/259 (38%), Gaps = 29/259 (11%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H +AV + + P L + + D+T + W + H +++SV F ++ F
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS-F 118
Query: 157 CTGGRDGNIMVWDTRCNK-KDGFYRQVNQISGAH---------NTSDKQTPSKPKKKQNS 206
T D + VW T K + +N + A + SD +T K K +
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV-KLWDKSSR 177
Query: 207 KGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPG 266
+ + + VT V F T ++A +D +KVWD+R + L
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR-------------LLQH 224
Query: 267 SSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLS 326
+ L +G+ L +D + + ++ ++ + +GHQ V + S
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL--MEGRLLYTLHGHQGPATTV--AFS 280
Query: 327 PDDQFLVSGSSDEAAYIWK 345
++ SG SDE +WK
Sbjct: 281 RTGEYFASGGSDEQVMVWK 299
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 23/175 (13%)
Query: 216 QQSVTVVLFQDENTLVSAGAVDGIIKVW--DLRKNYTAYRQEPIASKSFLYPGSSTRKLG 273
+ +VT V F L+++G+ D +++W +++ T +R +S +
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG----- 115
Query: 274 YSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLV 333
S + S T+ T ++F+++ Q+ + + SPD + +V
Sbjct: 116 -QSFVTASDDKTVKVWATHRQKFLFSLS-------------QHINWVRCAKFSPDGRLIV 161
Query: 334 SGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIW 388
S S D+ +W S+ + H VT V + PS T IA DNT+K+W
Sbjct: 162 SASDDKTVKLWDKSSR-ECVHSYCEHGGFVTYVDFHPSG-TCIAAAGMDNTVKVW 214
Score = 36.6 bits (83), Expect = 0.085
Identities = 41/183 (22%), Positives = 70/183 (38%), Gaps = 14/183 (7%)
Query: 70 ANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKA 129
A+++ V+++ T Q F + H N V + P +V+A+ D+T K WD +
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
Query: 130 GELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR----QVNQI 185
E + + H + V F + G D + VWD R ++ Y+ VN +
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCI-AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGL 235
Query: 186 SGAHN-----TSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII 240
S + T+ + K + L Q T V F ++G D +
Sbjct: 236 SFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 241 KVW 243
VW
Sbjct: 296 MVW 298
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 53.1 bits (126), Expect = 9e-07
Identities = 64/302 (21%), Positives = 109/302 (36%), Gaps = 53/302 (17%)
Query: 92 KEWMAHWNAVFDLAWVPGELKLVTAAGDQT-AKFWDVKAGELIGTCKGHQCSLKSVAFSK 150
+E +AH + V L +L+ GD W + I + GH ++SV +
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73
Query: 151 FEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLA 210
E+ + G + G+I VWD +K L
Sbjct: 74 PEELIVA-GSQSGSIRVWDLEA---------------------------------AKILR 99
Query: 211 PSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTR 270
+ + ++ + F V++G+ D IK+WD+R+ +R Y G S
Sbjct: 100 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR----------YRGHSQ- 148
Query: 271 KLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQ 330
L G L + D + ++++T K ++ F GH V+ P++
Sbjct: 149 --AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM--MSEFPGHTGPVNVVE--FHPNEY 202
Query: 331 FLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRL 390
L SGSSD W + +Q + + G V SV + P + C D + W
Sbjct: 203 LLASGSSDRTIRFWDLE-KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEP 261
Query: 391 NR 392
R
Sbjct: 262 ER 263
Score = 47.8 bits (112), Expect = 4e-05
Identities = 34/115 (29%), Positives = 52/115 (45%), Gaps = 6/115 (5%)
Query: 55 CTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLV 114
C+ P E V A +++ ++L++ RK C + H AV L + P L
Sbjct: 109 CSLDFHPYGEFV-ASGSQDTNIKLWDIR----RKGCVFRYRGHSQAVRCLRFSPDGKWLA 163
Query: 115 TAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWD 169
+AA D T K WD+ AG+++ GH + V F E + +G D I WD
Sbjct: 164 SAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWD 217
Score = 46.6 bits (109), Expect = 8e-05
Identities = 44/192 (22%), Positives = 80/192 (41%), Gaps = 16/192 (8%)
Query: 66 VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
+LA ++ V L++ + C H + V + E +V + + + W
Sbjct: 35 LLATGGDDCRVNLWSIN----KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQI 185
D++A +++ T GH+ ++ S+ F + + V +G +D NI +WD R YR +Q
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFRYRGHSQA 149
Query: 186 ----------SGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGA 235
+ +D T K K ++ V VV F L+++G+
Sbjct: 150 VRCLRFSPDGKWLASAADDHT-VKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
Query: 236 VDGIIKVWDLRK 247
D I+ WDL K
Sbjct: 209 SDRTIRFWDLEK 220
Score = 37.0 bits (84), Expect = 0.065
Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 8/77 (10%)
Query: 327 PDDQFLVSGSSDEAAYIWKVSTPWQPPTVLL--GHSQEVTSVCWCPSDFTKIATCSDDNT 384
P +F+ SGS D +W + + V GHSQ V + + P D +A+ +DD+T
Sbjct: 115 PYGEFVASGSQDTNIKLWDIR---RKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHT 170
Query: 385 LKIWRLNRG--LEEKPG 399
+K+W L G + E PG
Sbjct: 171 VKLWDLTAGKMMSEFPG 187
Score = 37.0 bits (84), Expect = 0.065
Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 4/83 (4%)
Query: 67 LAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
LA A ++ V+L++ + K E+ H V + + P E L + + D+T +FWD
Sbjct: 162 LASAADDHTVKLWDLTAG----KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Query: 127 VKAGELIGTCKGHQCSLKSVAFS 149
++ +++ +G ++SV F+
Sbjct: 218 LEKFQVVSCIEGEPGPVRSVLFN 240
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 53.1 bits (126), Expect = 9e-07
Identities = 64/258 (24%), Positives = 99/258 (38%), Gaps = 30/258 (11%)
Query: 97 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVF 156
H + + D + P KL T++GD T K WD+ G+ I T +GH ++ S + V
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV- 451
Query: 157 CTGGRDGNIMVWDT---RCN-KKDGFYRQVNQISGAHNTSDKQTPSKPKKK---QNSKGL 209
+ D +WD RC G VN I ++ T S K G+
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
Query: 210 APS--VDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSF-LYPG 266
S+ +F ++++ G+ K+WD RK PI S PG
Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLL------PIVSIDIGPSPG 565
Query: 267 SSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLS 326
+ DS+G L A + + + ++ LK+ + GH+N V S
Sbjct: 566 NEVN--------FDSSGRVL-AQASGNGV--IHLLDLKSGEIHKLMGHENEAHTV--VFS 612
Query: 327 PDDQFLVSGSSDEAAYIW 344
D + L SG SD W
Sbjct: 613 HDGEILFSGGSDGTVRTW 630
Score = 38.9 bits (89), Expect = 0.017
Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 6/116 (5%)
Query: 282 TGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAA 341
+G L + D + ++++ K + F GH + + + F+ S S D+ +
Sbjct: 405 SGDKLATSSGDTTVKLWDLC--KGDCILTFEGHSRAVW--SCTWHSCGNFVASSSLDKTS 460
Query: 342 YIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEK 397
IW V++ + L GH+ V S+ + P T + T S D TL IW G+ E+
Sbjct: 461 KIWDVNSE-RCRCTLYGHTDSVNSIEFFPFSNT-LLTSSADKTLSIWDARTGICEQ 514
Score = 36.6 bits (83), Expect = 0.085
Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 6/72 (8%)
Query: 324 SLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVL--LGHSQEVTSVCWCPSDFTKIATCSD 381
S+ P LVS D +WKV + +L GH+ ++ C+ PS K+AT S
Sbjct: 359 SMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSG-DKLATSSG 414
Query: 382 DNTLKIWRLNRG 393
D T+K+W L +G
Sbjct: 415 DTTVKLWDLCKG 426
Score = 33.5 bits (75), Expect = 0.72
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 53 FGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELK 112
+ CT+ S N +A ++ + ++++ S+ +C H ++V + + P
Sbjct: 440 WSCTWHSCGNF---VASSSLDKTSKIWDVNSE----RCRCTLYGHTDSVNSIEFFPFSNT 492
Query: 113 LVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAF 148
L+T++ D+T WD + G + GH S+ F
Sbjct: 493 LLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIF 528
>gi|24041023 embryonic ectoderm development isoform b [Homo sapiens]
Length = 400
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/205 (25%), Positives = 94/205 (45%), Gaps = 30/205 (14%)
Query: 9 QPQLGVLRNGWSSQY--PL------QSLLTGYQCSGNDEHT---SYGETGVPVPPFGCTF 57
QP GV N W S+ PL + +T Y+C E SY + + C +
Sbjct: 94 QPLFGVQFN-WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAW 152
Query: 58 SSAPNMEH-VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELK-LVT 115
+ N H +LAVA G +R+ N + +C K ++ H NA+ +L + P + L++
Sbjct: 153 TYDSNTSHPLLAVAGSRGIIRIINPITM----QCIKHYVGHGNAINELKFHPRDPNLLLS 208
Query: 116 AAGDQTAKFWDVKAGELI---GTCKGHQCSLKSVAFSKF-EKAVFCTGGRDGNIMVWDTR 171
+ D + W+++ L+ G +GH+ + S + EK + C G D ++ +W R
Sbjct: 209 VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC--GMDHSLKLW--R 264
Query: 172 CNKKDGFYRQVNQISGAHNTSDKQT 196
N K R +N I +++ + +T
Sbjct: 265 INSK----RMMNAIKESYDYNPNKT 285
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 12/85 (14%)
Query: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCP 370
GH N+ +K D L+S S D A +W + T + GH EV S
Sbjct: 188 GHGNAINELKFH-PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS----- 241
Query: 371 SDFT----KIATCSDDNTLKIWRLN 391
+D+ KI +C D++LK+WR+N
Sbjct: 242 ADYDLLGEKIMSCGMDHSLKLWRIN 266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,115,998
Number of Sequences: 37866
Number of extensions: 1652778
Number of successful extensions: 9467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 180
Number of HSP's successfully gapped in prelim test: 460
Number of HSP's that attempted gapping in prelim test: 6832
Number of HSP's gapped (non-prelim): 2664
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.