Guide to the Human Genome
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Search of human proteins with 11321603

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
         (557 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]          1153   0.0  
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]          1153   0.0  
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]          1153   0.0  
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap...   457   e-128
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap...   457   e-128
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap...   420   e-117
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]           293   3e-79
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]            211   2e-54
gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]           180   3e-45
gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]            180   3e-45
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]           134   2e-31
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]         76   9e-14
gi|87241872 ring finger protein 151 [Homo sapiens]                     75   2e-13
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]            67   3e-11
gi|30520320 ring finger protein 166 [Homo sapiens]                     57   4e-08
gi|37595555 ring finger protein 125 [Homo sapiens]                     54   3e-07
gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens]            49   1e-05
gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens]             49   1e-05
gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens]          47   6e-05
gi|4508005 tripartite motif-containing 26 [Homo sapiens]               46   8e-05
gi|40288191 XIAP associated factor 1 isoform 1 [Homo sapiens]          45   1e-04
gi|7705415 hook homolog 1 [Homo sapiens]                               45   2e-04
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       45   2e-04
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    44   4e-04
gi|157785668 coiled-coil domain containing 39 [Homo sapiens]           44   4e-04
gi|62865604 tripartite motif protein 31 [Homo sapiens]                 44   5e-04
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             43   7e-04
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    43   7e-04
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    43   7e-04
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    43   7e-04

>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score = 1153 bits (2982), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
           MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60

Query: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
           GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120

Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
           ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180

Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
           QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240

Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
           HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300

Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
           KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360

Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
           NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420

Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
           VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480

Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
           RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540

Query: 541 DTLFLKVAVDLTDLEDL 557
           DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557


>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score = 1153 bits (2982), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
           MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60

Query: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
           GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120

Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
           ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180

Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
           QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240

Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
           HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300

Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
           KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360

Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
           NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420

Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
           VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480

Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
           RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540

Query: 541 DTLFLKVAVDLTDLEDL 557
           DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557


>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score = 1153 bits (2982), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
           MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1   MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60

Query: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
           GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61  GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120

Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
           ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180

Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
           QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240

Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
           HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300

Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
           KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360

Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
           NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420

Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
           VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480

Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
           RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540

Query: 541 DTLFLKVAVDLTDLEDL 557
           DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557


>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
           sapiens]
          Length = 568

 Score =  457 bits (1175), Expect = e-128
 Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)

Query: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84

Query: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143

Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203

Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
           CP+ C+ + +L++E+  HL+ C  A   C FK YGC      + ++ HE S+  +H+ L+
Sbjct: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263

Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323

Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377

Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437

Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497

Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555

Query: 545 LKVAVDLTDLED 556
           +KV VD +DL D
Sbjct: 556 IKVIVDTSDLPD 567


>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
           sapiens]
          Length = 568

 Score =  457 bits (1175), Expect = e-128
 Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)

Query: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84

Query: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143

Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203

Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
           CP+ C+ + +L++E+  HL+ C  A   C FK YGC      + ++ HE S+  +H+ L+
Sbjct: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263

Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323

Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377

Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437

Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497

Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555

Query: 545 LKVAVDLTDLED 556
           +KV VD +DL D
Sbjct: 556 IKVIVDTSDLPD 567


>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
           sapiens]
          Length = 543

 Score =  420 bits (1080), Expect = e-117
 Identities = 222/552 (40%), Positives = 342/552 (61%), Gaps = 46/552 (8%)

Query: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84

Query: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143

Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203

Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
           CP+ C+ + +L++E                            + ++ HE S+  +H+ L+
Sbjct: 204 CPHKCSVQTLLRSE-------------------------GTNQQIKAHEASSAVQHVNLL 238

Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 239 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 298

Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 299 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 352

Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 353 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 412

Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 413 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 472

Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 473 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 530

Query: 545 LKVAVDLTDLED 556
           +KV VD +DL D
Sbjct: 531 IKVIVDTSDLPD 542


>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
          Length = 501

 Score =  293 bits (750), Expect = 3e-79
 Identities = 172/528 (32%), Positives = 276/528 (52%), Gaps = 64/528 (12%)

Query: 38  RLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP----------ICPVDKEV 87
           +LE +Y C+ C +VL  P Q  CGHR+C  C+ S+  L++ P          I      +
Sbjct: 27  KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASI--LSSGPQNCAACVHEGIYEEGISI 84

Query: 88  IKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQD-HLQQCLFQPVQCSNEKCRE 146
           ++S   F DN  +REV +L   C +  GC  K  L  Y+  H  +C     +C    C+ 
Sbjct: 85  LESSSAFPDNAARREVESLPAVCPS-DGCTWKGTLKEYESCHEGRCPLMLTECP--ACKG 141

Query: 147 PVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKT 206
            V   + + HL   C  R   C +C+      +++ H E +CP++P+ C     K I + 
Sbjct: 142 LVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE-VCPKFPLTCDGCGKKKIPRE 200

Query: 207 EVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISD 266
           +  +H+  C +    C F   GC  T +    Q+HE   LREH+ ++L   ++ +  + D
Sbjct: 201 KFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGD 260

Query: 267 LHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQV 326
              +     S++ Q  E+++K    F+    +  +              +  +A   ++ 
Sbjct: 261 QSHA----GSELLQRCESLEKKTATFENIVCVLNRE----------VERVAMTAEACSRQ 306

Query: 327 HQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQ 386
           H+L Q               + ++ +  K+  LE +                 I +    
Sbjct: 307 HRLDQ---------------DKIEALSSKVQQLERS-----------------IGLKDLA 334

Query: 387 LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARA 446
           ++  E++   +E + Y+G  IWK++D+  K++EAV G   +IFS +FYTSR GY++C R 
Sbjct: 335 MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394

Query: 447 YLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSS 506
           YLNGDG+GRG+HLSL+FVVM+G  D+LL+WPF Q+VTLMLLDQ+ ++++++ F+PD  SS
Sbjct: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSS 454

Query: 507 SFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDL 554
           SF+RP  +MNIASGCP F   S +E AKN+Y++DD +F+K  VDLT L
Sbjct: 455 SFQRPVNDMNIASGCPLFCPVSKME-AKNSYVRDDAIFIKAIVDLTGL 501


>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
          Length = 416

 Score =  211 bits (536), Expect = 2e-54
 Identities = 143/429 (33%), Positives = 223/429 (51%), Gaps = 81/429 (18%)

Query: 161 CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEHLAVC 215
           CQ  KE    C    +  N +N E+ +CP+    C     + I     L+T+   H  V 
Sbjct: 27  CQDPKEPRALCCAGCLSENPRNGEDQICPK----CRGEDLQSISPGSRLRTQEKAHPEVA 82

Query: 216 PEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQ---------------L 260
            EA   CPF   GC+     +++Q+HE ++   H+ L+L    Q               L
Sbjct: 83  -EAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMAL 141

Query: 261 EEQISDLHK-------------------SLEQKESKIQQLAETIKKLEKEFKQFAQLFGK 301
           E+ +SDL                     S  Q+E  +Q   +  +KL  E +   ++F +
Sbjct: 142 EQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK--EKLLAELEGKLRVF-E 198

Query: 302 NGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLEN 361
           N   + N +V ASH+     L   +HQ         ++ D           +++I  LE 
Sbjct: 199 NIVAVLNKEVEASHLA----LATSIHQ---------SQLD-----------RERILSLE- 233

Query: 362 NDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAV 421
             QR+  L++   + D         L K E+  +L+E   ++G  +WK+T+   +  E+ 
Sbjct: 234 --QRVVELQQTLAQKDQ-------ALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESA 284

Query: 422 DGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQR 481
            G TVS+FS +FYT++ GY+LC R YLNGDG+G+ +HLSL+ V+MRGE+D+LL WPFR +
Sbjct: 285 CGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK 344

Query: 482 VTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDD 541
           VT MLLDQ+ +++ ++ F+PD +S+SF+RP  E N+ASGCP F   S L++ K+AY+KDD
Sbjct: 345 VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404

Query: 542 TLFLKVAVD 550
           T+FLK  V+
Sbjct: 405 TMFLKCIVE 413


>gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]
          Length = 522

 Score =  180 bits (456), Expect = 3e-45
 Identities = 143/525 (27%), Positives = 235/525 (44%), Gaps = 89/525 (16%)

Query: 32  EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCIL-SLRELNTVPICPVDKEVIKS 90
           + +F   LE +Y+C  C   L    QT CGHRFC+ CI+ S+R+      CPVD E++  
Sbjct: 57  DVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK--CPVDNEILLE 114

Query: 91  QEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLR 150
            ++F DN  KRE+L+L V C N  GC  K+ L   +DH   C F  + C   +C+ P  +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNE-GCLHKMELRHLEDHQAHCEFALMDCP--QCQRPFQK 171

Query: 151 KDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDE 210
             +  H+   C  R+  C  C   +   + + H++N CP   V C   C  I+++ ++  
Sbjct: 172 FHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQN-CPLANVIC-EYCNTILIREQMPN 229

Query: 211 HLAV-CPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHK 269
           H  + CP A   C F  +GC    +R +L +H            L++N Q          
Sbjct: 230 HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARH------------LQENTQ---------- 267

Query: 270 SLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL 329
                 S ++ LA+ +  L               S +P+    + +I +    +  +HQL
Sbjct: 268 ------SHMRMLAQAVHSL---------------SVIPD----SGYISEVRNFQETIHQL 302

Query: 330 LQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSK 389
              + +Q ++  +R L   ++T    ++ L+   + L                       
Sbjct: 303 EGRLVRQDHQ--IRELTAKMETQSMYVSELKRTIRTL----------------------- 337

Query: 390 NEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLN 449
            E++   +E    NG  IWK+ ++ M  +   +   V I S  FYT + GY+LC R +L 
Sbjct: 338 -EDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQ 396

Query: 450 GDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSG---KKNIMETFKPDPNS 505
              + R  +++SL+   M+GE+DS L WPF+  + L +LDQS    ++N  E     P  
Sbjct: 397 LPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPEL 456

Query: 506 SSFKRPDGEMNIAS-GCPRFVAHSVLENAKNAYIKDDTLFLKVAV 549
            +F+RP    N    G   F+    L   +  +IKDDTL ++  V
Sbjct: 457 LAFQRPTIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEV 499


>gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]
          Length = 522

 Score =  180 bits (456), Expect = 3e-45
 Identities = 143/525 (27%), Positives = 235/525 (44%), Gaps = 89/525 (16%)

Query: 32  EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCIL-SLRELNTVPICPVDKEVIKS 90
           + +F   LE +Y+C  C   L    QT CGHRFC+ CI+ S+R+      CPVD E++  
Sbjct: 57  DVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK--CPVDNEILLE 114

Query: 91  QEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLR 150
            ++F DN  KRE+L+L V C N  GC  K+ L   +DH   C F  + C   +C+ P  +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNE-GCLHKMELRHLEDHQAHCEFALMDCP--QCQRPFQK 171

Query: 151 KDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDE 210
             +  H+   C  R+  C  C   +   + + H++N CP   V C   C  I+++ ++  
Sbjct: 172 FHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQN-CPLANVIC-EYCNTILIREQMPN 229

Query: 211 HLAV-CPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHK 269
           H  + CP A   C F  +GC    +R +L +H            L++N Q          
Sbjct: 230 HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARH------------LQENTQ---------- 267

Query: 270 SLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL 329
                 S ++ LA+ +  L               S +P+    + +I +    +  +HQL
Sbjct: 268 ------SHMRMLAQAVHSL---------------SVIPD----SGYISEVRNFQETIHQL 302

Query: 330 LQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSK 389
              + +Q ++  +R L   ++T    ++ L+   + L                       
Sbjct: 303 EGRLVRQDHQ--IRELTAKMETQSMYVSELKRTIRTL----------------------- 337

Query: 390 NEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLN 449
            E++   +E    NG  IWK+ ++ M  +   +   V I S  FYT + GY+LC R +L 
Sbjct: 338 -EDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQ 396

Query: 450 GDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSG---KKNIMETFKPDPNS 505
              + R  +++SL+   M+GE+DS L WPF+  + L +LDQS    ++N  E     P  
Sbjct: 397 LPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPEL 456

Query: 506 SSFKRPDGEMNIAS-GCPRFVAHSVLENAKNAYIKDDTLFLKVAV 549
            +F+RP    N    G   F+    L   +  +IKDDTL ++  V
Sbjct: 457 LAFQRPTIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEV 499


>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
          Length = 470

 Score =  134 bits (337), Expect = 2e-31
 Identities = 68/160 (42%), Positives = 101/160 (63%), Gaps = 13/160 (8%)

Query: 403 NGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLY 462
           +G LIWK+  Y  + +EA     +  FS +FYT + GY+L   A+LNG+GSG G+HLSLY
Sbjct: 307 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY 366

Query: 463 FVVMRGEFDSLLQWPFRQRVTLMLLDQSG-----KKNIMETFKPDPNSSSFKRPD----- 512
             V+ G FD+LL+WPF +RVT  LLDQS       +++ ETF PDPN  +F++P      
Sbjct: 367 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS 426

Query: 513 -GEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDL 551
             E ++  G P+F++H  +   K  Y++DD +F++ AV+L
Sbjct: 427 LDESSLGFGYPKFISHQDIR--KRNYVRDDAVFIRAAVEL 464



 Score =  105 bits (263), Expect = 8e-23
 Identities = 71/302 (23%), Positives = 120/302 (39%), Gaps = 59/302 (19%)

Query: 29  PSIEYQFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEV 87
           P  +Y+F+E+ + R  C  C   +  P Q   CGHRFC  C+           CP D+  
Sbjct: 2   PGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFK-CPEDQLP 60

Query: 88  IKSQEVFKDNCCKREVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNE---- 142
           +   +++ D   + +VL L + C ++  GC     L   Q HL  C F  + C N     
Sbjct: 61  LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK 120

Query: 143 -------------------------------------------------KCREPVLRKDL 153
                                                            KC   ++R+ L
Sbjct: 121 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL 180

Query: 154 KEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNC-AKIILKTEVDEHL 212
            +H ++ C  R + C YC K+ V   +Q+H+   CP  PV CPN C    + + ++  HL
Sbjct: 181 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQ-CPRLPVACPNQCGVGTVAREDLPGHL 239

Query: 213 A-VCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSL 271
              C  A   CPFK  GC     +  + +H   +++ H+ ++     +  +++ +L + L
Sbjct: 240 KDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRREL 299

Query: 272 EQ 273
           E+
Sbjct: 300 EE 301


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 6/124 (4%)

Query: 44  KCAFCHSVLHNPHQTGCGHRFCQHCILS--LRELNTVPICPVDKEVIKSQEVFKDNCCKR 101
           KCA CH VL +P  T CGH FC  C+L   ++E +    C   +  + ++E+      KR
Sbjct: 17  KCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARC---RGRLSAKELNHVLPLKR 73

Query: 102 EVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS 160
            +L L + C+ A  GC   V L +  +HL++C F P +C +  C + +LR+D++ H+  +
Sbjct: 74  LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDA 133

Query: 161 CQFR 164
           C  R
Sbjct: 134 CDAR 137



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%)

Query: 194 FCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSA 245
           +    C +++   ++ EHL  C  A   C  +H GC     RR+++ H   A
Sbjct: 84  YATRGCGRVVKLQQLPEHLERCDFAPARC--RHAGCGQVLLRRDVEAHMRDA 133


>gi|87241872 ring finger protein 151 [Homo sapiens]
          Length = 245

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 3/135 (2%)

Query: 35  FVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVF 94
           F    +  + C+ CH VL  P +  C H FC+ CI  LR L     CP  ++ +K ++V 
Sbjct: 10  FASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCI--LRWLARQKTCPCCRKEVKRKKVV 67

Query: 95  KDNCCKREVLNLYVYCSNA-PGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDL 153
             N  ++ +  L V C NA  GC     L   + H   C F+   C NE C   V R  L
Sbjct: 68  HMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQVPRGTL 127

Query: 154 KEHLSASCQFRKEKC 168
            EH     Q  +++C
Sbjct: 128 AEHRQHCQQGSQQRC 142


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 61/276 (22%), Positives = 103/276 (37%), Gaps = 84/276 (30%)

Query: 35  FVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVF 94
           F E+   +  C  C SV  +P  T CGH FC+ C L   +      CPVD   +K   V 
Sbjct: 121 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEK------CPVDN--VKLTVVV 172

Query: 95  KDNCCKREVLNLYVYC--------SNAP--------GCNAKVILGRYQDHLQQCLFQPVQ 138
            +     ++  L+++C        S  P        GC   + L   +DH   C ++PV+
Sbjct: 173 NNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVR 232

Query: 139 CSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNN 198
           C N     P+LR +L+ HL        ++C + K                          
Sbjct: 233 CPNNPSCPPLLRMNLEAHL--------KECEHIK-------------------------- 258

Query: 199 CAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNV 258
                           CP ++       YGC     +   + H  +   E ++  L+   
Sbjct: 259 ----------------CPHSK-------YGCTFIGNQDTYETHLETCRFEGLKEFLQ--- 292

Query: 259 QLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQ 294
           Q +++  ++H +L QK+ +I  L   + KL ++  Q
Sbjct: 293 QTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQ 328


>gi|30520320 ring finger protein 166 [Homo sapiens]
          Length = 237

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 5/104 (4%)

Query: 39  LEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDN 97
           LE +Y C  C  V H P   G CGH FC  C+    ++ + P+CP+ +     ++V K  
Sbjct: 27  LEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPS-PLCPLCRLPFDPKKVDKAT 85

Query: 98  CCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSN 141
             ++++ +    C    GCN KV L + + H+  CL    Q +N
Sbjct: 86  HVEKQLSSYKAPCR---GCNKKVTLAKMRVHISSCLKVQEQMAN 126


>gi|37595555 ring finger protein 125 [Homo sapiens]
          Length = 232

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 21/156 (13%)

Query: 43  YKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKRE 102
           + CA C  VLH P +T CGH FC+ CI +  + N    CP  +  + S+ V   +  KR 
Sbjct: 35  FDCAVCLEVLHQPVRTRCGHVFCRSCIATSLK-NNKWTCPYCRAYLPSEGVPATDVAKR- 92

Query: 103 VLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQ 162
           + + Y  C+    C+  V L   + H++ C         +K  +        E  +A C 
Sbjct: 93  MKSEYKNCAE---CDTLVCLSEMRAHIRTC---------QKYIDKYGPLQELEETAARC- 139

Query: 163 FRKEKCLYCKKDVVVINLQNH--EENLCPEYPVFCP 196
                C +C++++   +L +H    +     PVFCP
Sbjct: 140 ----VCPFCQRELYEDSLLDHCITHHRSERRPVFCP 171


>gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens]
          Length = 317

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 39/129 (30%), Positives = 55/129 (42%), Gaps = 9/129 (6%)

Query: 34  QFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
           +F   ++E   C  C  VL  P Q   C H FC  CI      +    CPVD+ V+    
Sbjct: 7   RFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQW--FSQQQTCPVDRSVVTVAH 64

Query: 93  VFKDNCCKREVLN-LYVYCSNAP-GCNAKVILGRYQDHLQQCLF---QPVQCSNEKCREP 147
           +       R +L+ L + C NA  GC+A V L     HL  C     +PV C  + C   
Sbjct: 65  LRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTC-EQGCGLE 123

Query: 148 VLRKDLKEH 156
           + + +L  H
Sbjct: 124 MPKDELPNH 132


>gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens]
          Length = 317

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 39/129 (30%), Positives = 55/129 (42%), Gaps = 9/129 (6%)

Query: 34  QFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
           +F   ++E   C  C  VL  P Q   C H FC  CI      +    CPVD+ V+    
Sbjct: 7   RFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQW--FSQQQTCPVDRSVVTVAH 64

Query: 93  VFKDNCCKREVLN-LYVYCSNAP-GCNAKVILGRYQDHLQQCLF---QPVQCSNEKCREP 147
           +       R +L+ L + C NA  GC+A V L     HL  C     +PV C  + C   
Sbjct: 65  LRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTC-EQGCGLE 123

Query: 148 VLRKDLKEH 156
           + + +L  H
Sbjct: 124 MPKDELPNH 132


>gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens]
          Length = 282

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 10/106 (9%)

Query: 116 CNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS------CQFRKEKCL 169
           C   V+   +  H   CL   V C   +C EPV ++ ++EH          CQ R  +C 
Sbjct: 11  CKRHVVSANFTLHEAYCLRFLVLCP--ECEEPVPKETMEEHCKLEHQQANECQERPVECK 68

Query: 170 YCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVC 215
           +CK D+ +  L+ H E+ C      C   C + I+   + +H  VC
Sbjct: 69  FCKLDMQLSKLELH-ESYCGSRTELC-QGCGQFIMHRMLAQHRDVC 112


>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
          Length = 539

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 65/284 (22%), Positives = 118/284 (41%), Gaps = 48/284 (16%)

Query: 39  LEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN-TVPICPVDKEVIKSQEVFKDN 97
           LEE   C+ C   L +P    CGH FC+ C   +R ++ + P+CP+ K+  K + +    
Sbjct: 10  LEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFKKENI---- 65

Query: 98  CCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHL 157
              R V  L     N      KV  GR          QP + + E+ ++  L +  +E L
Sbjct: 66  ---RPVWQLASLVENIE--RLKVDKGR----------QPGEVTREQ-QDAKLCERHREKL 109

Query: 158 SASCQ-FRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEH 211
              C+   K  C+ C++       + H  +           +  KI+     L+ + D+ 
Sbjct: 110 HYYCEDDGKLLCVMCRES------REHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKI 163

Query: 212 LAVCPEAEQDCPFKHYGCAVTDKRRNLQQH-------EHSALREHMRLVLEKNVQLEEQI 264
                + E D        A   K ++ +Q+        H  LRE    +LE+  +LE+++
Sbjct: 164 QGFQAKGEADI------LAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQEL 217

Query: 265 SDLHKSLEQK-ESKIQQLAETIKKLEKEFKQ-FAQLFGKNGSFL 306
           ++  +  + +   ++ +LA  I +LE + +Q  A+L      FL
Sbjct: 218 TEGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFL 261


>gi|40288191 XIAP associated factor 1 isoform 1 [Homo sapiens]
          Length = 301

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 14/126 (11%)

Query: 99  CKREVLNLY-----VYCSN----APGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVL 149
           CKR V++        YC       P C   V     ++H   C  +  Q     C++ + 
Sbjct: 11  CKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEH---CKLEHQQVGCTMCQQSMQ 67

Query: 150 RKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVD 209
           +  L+ H +  CQ R  +C +CK D+ +  L+ H E+ C      C   C + I+   + 
Sbjct: 68  KSSLEFHKANECQERPVECKFCKLDMQLSKLELH-ESYCGSRTELC-QGCGQFIMHRMLA 125

Query: 210 EHLAVC 215
           +H  VC
Sbjct: 126 QHRDVC 131


>gi|7705415 hook homolog 1 [Homo sapiens]
          Length = 728

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 43/180 (23%), Positives = 85/180 (47%), Gaps = 16/180 (8%)

Query: 239 QQHEH-SALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQ 297
           Q+H   + L    RL  E+  +L++QI DL KSL+++ SK +   E+  KL+++ +   +
Sbjct: 498 QKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE--GESSSKLKQKLEAHME 555

Query: 298 LFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT 357
              +    L   Q           L+  ++Q +Q +N+ +    L+   E +  ++++  
Sbjct: 556 KLTEVHEELQKKQELIED------LQPDINQNVQKINELEAA--LQKKDEDMKAMEERYK 607

Query: 358 L-LENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMK 416
           + LE     +  L+ + N     I + + QL++ E R ++LE  C     + K  DY+ K
Sbjct: 608 MYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC----KVAKFRDYEEK 663



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 3/57 (5%)

Query: 238 LQQHEHSALREHMRLVLEKNVQLE---EQISDLHKSLEQKESKIQQLAETIKKLEKE 291
           +  H   +L E ++       QLE    Q+ DLH  L  +  +   LA  +K+LE++
Sbjct: 349 MYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEK 405


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 31/130 (23%), Positives = 51/130 (39%), Gaps = 29/130 (22%)

Query: 33  YQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
           Y + E +++   C  C   L +P  T CGH +C  C+ +   L     CP+D++ +  Q 
Sbjct: 29  YSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNF--LVEKDFCPMDRKPLVLQH 86

Query: 93  VFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKD 152
             K +    ++LN                       L  C F+      E C + + R D
Sbjct: 87  CKKSSILVNKLLNKL---------------------LVTCPFR------EHCTQVLQRCD 119

Query: 153 LKEHLSASCQ 162
           L+ H   SC+
Sbjct: 120 LEHHFQTSCK 129


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/177 (22%), Positives = 81/177 (45%), Gaps = 25/177 (14%)

Query: 239 QQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQL 298
           ++ E+S LRE M    E N     +   L   +E K+SKI  +   ++ LE+E     Q+
Sbjct: 353 KEKENSMLREEMHRRFE-NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI----QM 407

Query: 299 FGKNGSF--------LPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFD-----LRPL 345
              NG+         +  ++V+ SH   S +++ +V QL + ++ ++ +++        L
Sbjct: 408 LKSNGALSTEEREEEMKQMEVYRSH---SKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464

Query: 346 MEAVDTVKQKITLLENN----DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
              +  VKQ+++  +        +L  L  + +    HI + K  L+  E+R  +L+
Sbjct: 465 QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 33/167 (19%), Positives = 82/167 (49%), Gaps = 15/167 (8%)

Query: 246 LREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSF 305
           L+EH   +    ++ + ++  L  +LEQK+ +  ++   +KK  +   + A+   +    
Sbjct: 678 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE-ARASPEMSDR 736

Query: 306 LPNIQ-VFASHIDKSAWLEAQVHQLLQMVNQQQNKFD-----LRPLMEAVDTVKQKITLL 359
           + +++     + D+S+  +A+V +LL+++ + +N+ +     +  L   V    +K+  L
Sbjct: 737 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796

Query: 360 ENNDQ----RLAVLEEETNKHDTHINIHKAQLS----KNEERFKLLE 398
           ++ +Q    + A + EE  + + ++N    QL     K ++R + LE
Sbjct: 797 KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 843



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 36/165 (21%), Positives = 72/165 (43%), Gaps = 20/165 (12%)

Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
           +T++  + +QH    L+E +    ++   L+ ++  L   LE+KE+           L K
Sbjct: 492 LTNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLRLEEKET----------MLNK 540

Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
           + KQ   +  + G+    I      +D     E +V+ L + +   Q +  LR   + + 
Sbjct: 541 KTKQIQDMAEEKGTQAGEIHDLKDMLDVK---ERKVNVLQKKIENLQEQ--LRDKEKQMS 595

Query: 351 TVKQKITLLE----NNDQRLAVLEEETNKHDTHINIHKAQLSKNE 391
           ++K+++  L+    N D  L  LEE   + +  I   K Q  ++E
Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 640



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 34/199 (17%), Positives = 82/199 (41%), Gaps = 26/199 (13%)

Query: 230 AVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLE 289
           A++ + R  +  +    R H + +  K  QL+E++S      E+ + K   L   I +++
Sbjct: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472

Query: 290 KEFKQ-----------FAQLFGKNGSFLPNIQVFASHI----DKSAWLEAQVHQLLQMVN 334
           +E  +              L  +      +I+V    +     ++A L+ +V  L   + 
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532

Query: 335 QQQNKFDLRPLMEAVDTVKQKIT----------LLENNDQRLAVLEEETNKHDTHINIHK 384
           +++   + +   +  D  ++K T          +L+  ++++ VL+++       +   +
Sbjct: 533 EKETMLN-KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 591

Query: 385 AQLSKNEERFKLLEGTCYN 403
            Q+S  +ER K L+    N
Sbjct: 592 KQMSSLKERVKSLQADTTN 610


>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
          Length = 941

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 9/158 (5%)

Query: 237 NLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFA 296
           ++QQ E    R    +  E+   LE +I +L KSLE+K+S    L   IKKL  +     
Sbjct: 457 HIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIK 516

Query: 297 QLFGKNG----SFLPNIQVFASHIDKSAWLEAQVHQLLQ--MVNQQQNKFDLRPLMEAVD 350
           +   KN     S +  I      ID+S     +     Q  M+     K +++   E + 
Sbjct: 517 KAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH 576

Query: 351 TVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLS 388
           +  +++  LE   Q+L    EE  +    I +HK  L+
Sbjct: 577 SKAEEVLSLEKRKQQLYTAMEERTE---EIKVHKTMLA 611


>gi|62865604 tripartite motif protein 31 [Homo sapiens]
          Length = 425

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 34 QFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPI-CPVDKEVIKSQE 92
          QFV +L+E   C  C  +L  P    CGH FC  CI  + E +     CP+ K  ++   
Sbjct: 5  QFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSVRKNA 64

Query: 93 V 93
          +
Sbjct: 65 I 65


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 43/202 (21%), Positives = 95/202 (47%), Gaps = 38/202 (18%)

Query: 231  VTDKRRNLQQH------EHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAET 284
            +T     L+ H      E + L++  +L++++ ++L+ +   L  ++EQ++   Q L + 
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199

Query: 285  IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL-LQMVNQQQNK---- 339
            +KK E+E K+                     I+K A L +++ +  + M   ++N+    
Sbjct: 1200 VKKEEEELKK-------------------EFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240

Query: 340  FDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEG 399
              +  L E + TVK++    +++ +R++ LE++T+     I + +A +  N++  + L  
Sbjct: 1241 MQITALNENLGTVKKE---WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE 1297

Query: 400  TCYNG-----KLIWKVTDYKMK 416
             C  G     KL  KV + + K
Sbjct: 1298 RCLKGEGEIEKLQTKVLELQRK 1319



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 51/228 (22%), Positives = 100/228 (43%), Gaps = 32/228 (14%)

Query: 200 AKIILKTEVDEHLAVCPEAEQDCPFKHYGCA-----VTDKRRNLQQHEHSALREHMRLVL 254
           AK   + ++  HL     A QD   +          VT K ++ Q+H  S L  H++   
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH-CSQLESHLKEYK 715

Query: 255 EKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFAS 314
           EK + LE++  +L   +++ E+   ++  + ++  ++ +Q  QL         ++++ A+
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL-------NTDLELRAT 768

Query: 315 HIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRL----AVLE 370
            + K   +E ++            + DL+   EA++++KQK+T  E   Q L      L 
Sbjct: 769 ELSKQLEMEKEI--------VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820

Query: 371 EETNKHDTHIN------IHKAQLSKNEERFKLLEGTCYNGKLIWKVTD 412
           +ET      +N      + + Q  K E+   + E +    KL  KV+D
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS-KVSD 867



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 13/164 (7%)

Query: 239 QQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQ---KESKIQQLAETIKKLEKEF--- 292
           QQH+     E   L      +L E  +DL + L Q   K+ KIQ L   ++K ++     
Sbjct: 488 QQHQ-----EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542

Query: 293 -KQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDT 351
            K+   L+ K  +      V     +K+  L+ QV QL + + + Q++   +      D 
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL-KNQSESHKQAQENLHDQ 601

Query: 352 VKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFK 395
           V+++   L     R+  LE   N+ ++ +N  K ++S+ + + K
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 39/156 (25%), Positives = 65/156 (41%), Gaps = 32/156 (20%)

Query: 243 HSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKN 302
           HS L E  R + E + +L+EQ     + L  KE ++  L   + +LE++ K+        
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE-------- 471

Query: 303 GSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENN 362
              + N       +DK+     Q HQ  Q + Q         L EA + ++Q +  + + 
Sbjct: 472 --KVTNSTELQHQLDKT----KQQHQEQQALQQSTT----AKLREAQNDLEQVLRQIGDK 521

Query: 363 DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
           DQ++  LE              A L K++E   LLE
Sbjct: 522 DQKIQNLE--------------ALLQKSKENISLLE 543



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 28/134 (20%), Positives = 59/134 (44%), Gaps = 26/134 (19%)

Query: 243 HSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKN 302
           H  L+E  +L  EK +  E+Q++DL   L + E ++++      +L+ +  +  Q     
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ----- 488

Query: 303 GSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKI----TL 358
                       H ++ A  ++   +L +  N      DL  ++  +    QKI     L
Sbjct: 489 -----------QHQEQQALQQSTTAKLREAQN------DLEQVLRQIGDKDQKIQNLEAL 531

Query: 359 LENNDQRLAVLEEE 372
           L+ + + +++LE+E
Sbjct: 532 LQKSKENISLLEKE 545



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 36/156 (23%), Positives = 67/156 (42%), Gaps = 31/156 (19%)

Query: 251  RLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKL----EKEFKQFAQLFGKNGSFL 306
            +L LE N  ++EQ+     +L+Q E + QQL   I +L    E++ KQ   L G+     
Sbjct: 928  QLKLELN-SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE----- 981

Query: 307  PNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENN---- 362
                           L+  V Q  ++ N+ Q +  L    + +   K+KI++L+NN    
Sbjct: 982  ---------------LKIAVLQKTELENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKS 1024

Query: 363  DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
             +    L+ +    ++ +   +  L   EE+  L +
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)

Query: 231  VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
            +T+++  LQ+      E  A  E MR+ L  K  +LEE + ++   LE++E + QQL   
Sbjct: 885  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944

Query: 285  IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
             KK+ ++     +   +  +    +Q+    +   A ++    ++L M +Q       R 
Sbjct: 945  RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002

Query: 345  LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
            L+E  + +    T L   +++   L +  NKH++ I+  + +L K E+  + LE
Sbjct: 1003 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V+ K R L++ E ++L++ +   +E    LE  IS L+  L   + K+Q  A T++ LE+
Sbjct: 1334 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
              K+F +           I+      ++ A   A   +L +  N+ Q + D   L+  +D
Sbjct: 1393 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1437

Query: 351  TVKQKITLLENNDQRL-AVLEEETN 374
              +Q ++ LE   ++   +L EE N
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKN 1462



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V D + N    E   L E +  +     + EE+  +L K   + ES I +L   +KK EK
Sbjct: 989  VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
              ++  +L  K       ++  AS   ++ A L+AQ+ +L   + +++ +     L  A+
Sbjct: 1049 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1096

Query: 350  DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
              +  +I    N  +++  LE   +     ++  +A  +K E++
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)

Query: 231  VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
            +T+++  LQ+      E  A  E MR+ L  K  +LEE + ++   LE++E + QQL   
Sbjct: 892  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 285  IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
             KK+ ++     +   +  +    +Q+    +   A ++    ++L M +Q       R 
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 345  LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
            L+E  + +    T L   +++   L +  NKH++ I+  + +L K E+  + LE
Sbjct: 1010 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V+ K R L++ E ++L++ +   +E    LE  IS L+  L   + K+Q  A T++ LE+
Sbjct: 1341 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
              K+F +           I+      ++ A   A   +L +  N+ Q + D   L+  +D
Sbjct: 1400 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1444

Query: 351  TVKQKITLLENNDQRL-AVLEEETN 374
              +Q ++ LE   ++   +L EE N
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKN 1469



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V D + N    E   L E +  +     + EE+  +L K   + ES I +L   +KK EK
Sbjct: 996  VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
              ++  +L  K       ++  AS   ++ A L+AQ+ +L   + +++ +     L  A+
Sbjct: 1056 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1103

Query: 350  DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
              +  +I    N  +++  LE   +     ++  +A  +K E++
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)

Query: 231  VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
            +T+++  LQ+      E  A  E MR+ L  K  +LEE + ++   LE++E + QQL   
Sbjct: 892  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 285  IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
             KK+ ++     +   +  +    +Q+    +   A ++    ++L M +Q       R 
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 345  LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
            L+E  + +    T L   +++   L +  NKH++ I+  + +L K E+  + LE
Sbjct: 1010 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V+ K R L++ E ++L++ +   +E    LE  IS L+  L   + K+Q  A T++ LE+
Sbjct: 1341 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
              K+F +           I+      ++ A   A   +L +  N+ Q + D   L+  +D
Sbjct: 1400 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1444

Query: 351  TVKQKITLLENNDQRL-AVLEEETN 374
              +Q ++ LE   ++   +L EE N
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKN 1469



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)

Query: 231  VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
            V D + N    E   L E +  +     + EE+  +L K   + ES I +L   +KK EK
Sbjct: 996  VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 291  EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
              ++  +L  K       ++  AS   ++ A L+AQ+ +L   + +++ +     L  A+
Sbjct: 1056 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1103

Query: 350  DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
              +  +I    N  +++  LE   +     ++  +A  +K E++
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,691,058
Number of Sequences: 37866
Number of extensions: 1010981
Number of successful extensions: 5957
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 361
Number of HSP's that attempted gapping in prelim test: 4563
Number of HSP's gapped (non-prelim): 1529
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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