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Search of human proteins with 106507301
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|106507301 DNA-directed DNA polymerase alpha 1 [Homo sapiens]
(1462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|106507301 DNA-directed DNA polymerase alpha 1 [Homo sapiens] 2949 0.0
gi|156616275 DNA-directed DNA polymerase delta 1 [Homo sapiens] 207 5e-53
gi|153792012 DNA polymerase zeta [Homo sapiens] 141 5e-33
gi|62198237 DNA-directed DNA polymerase epsilon [Homo sapiens] 49 4e-05
gi|31543091 MAK16 homolog [Homo sapiens] 47 1e-04
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 40 0.013
gi|27597090 suppressor of Ty 6 homolog [Homo sapiens] 40 0.016
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 40 0.022
gi|21327710 nucleosome assembly protein 1-like 3 [Homo sapiens] 38 0.063
gi|156071450 nardilysin isoform a [Homo sapiens] 38 0.082
gi|13376429 hypothetical protein LOC80011 [Homo sapiens] 38 0.082
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 37 0.11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 37 0.11
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 37 0.11
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 37 0.14
gi|42542392 CCAAT/enhancer binding protein zeta [Homo sapiens] 37 0.14
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 37 0.14
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens] 37 0.14
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 37 0.14
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 37 0.18
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 37 0.18
gi|6857816 E74-like factor 2 (ets domain transcription factor) i... 37 0.18
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 37 0.18
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 37 0.18
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 36 0.31
gi|210147567 hypothetical protein LOC220081 [Homo sapiens] 36 0.31
gi|55749531 splicing factor 3B subunit 2 [Homo sapiens] 36 0.31
gi|19923844 coiled-coil domain containing 82 [Homo sapiens] 35 0.41
gi|4505999 protein phosphatase 1G [Homo sapiens] 35 0.53
gi|29826282 protein phosphatase 1G [Homo sapiens] 35 0.53
>gi|106507301 DNA-directed DNA polymerase alpha 1 [Homo sapiens]
Length = 1462
Score = 2949 bits (7644), Expect = 0.0
Identities = 1462/1462 (100%), Positives = 1462/1462 (100%)
Query: 1 MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE 60
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
Sbjct: 1 MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE 60
Query: 61 VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK 120
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
Sbjct: 61 VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK 120
Query: 121 RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI 180
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
Sbjct: 121 RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI 180
Query: 181 LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE 240
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
Sbjct: 181 LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE 240
Query: 241 EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF 300
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
Sbjct: 241 EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF 300
Query: 301 LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF 360
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
Sbjct: 301 LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF 360
Query: 361 LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK 420
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
Sbjct: 361 LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK 420
Query: 421 IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN 480
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
Sbjct: 421 IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN 480
Query: 481 TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM 540
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
Sbjct: 481 TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM 540
Query: 541 AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE 600
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
Sbjct: 541 AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE 600
Query: 601 VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS 660
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
Sbjct: 601 VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS 660
Query: 661 KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER 720
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
Sbjct: 661 KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER 720
Query: 721 VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL 780
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
Sbjct: 721 VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL 780
Query: 781 MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA 840
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
Sbjct: 781 MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA 840
Query: 841 GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE 900
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
Sbjct: 841 GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE 900
Query: 901 LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL 960
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
Sbjct: 901 LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL 960
Query: 961 GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK 1020
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
Sbjct: 961 GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK 1020
Query: 1021 LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV 1080
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
Sbjct: 1021 LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV 1080
Query: 1081 RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT 1140
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
Sbjct: 1081 RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT 1140
Query: 1141 KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK 1200
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
Sbjct: 1141 KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK 1200
Query: 1201 QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL 1260
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
Sbjct: 1201 QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL 1260
Query: 1261 LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL 1320
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
Sbjct: 1261 LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL 1320
Query: 1321 TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ 1380
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
Sbjct: 1321 TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ 1380
Query: 1381 PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF 1440
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
Sbjct: 1381 PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF 1440
Query: 1441 LSRSGYSEVNLSKLFAGCAVKS 1462
LSRSGYSEVNLSKLFAGCAVKS
Sbjct: 1441 LSRSGYSEVNLSKLFAGCAVKS 1462
>gi|156616275 DNA-directed DNA polymerase delta 1 [Homo sapiens]
Length = 1107
Score = 207 bits (528), Expect = 5e-53
Identities = 212/791 (26%), Positives = 364/791 (46%), Gaps = 102/791 (12%)
Query: 487 FLMNRKIKGPCWLEVKSPQL---LNQPVSWCKVEAMALKPDLVNVIKDVSPP-------- 535
F+++ I G WLE+ + + L + + C++EA L D+V+ PP
Sbjct: 254 FMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVS-----HPPEGPWQRIA 308
Query: 536 PLVVMAFSMKTMQNA----KNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKD 591
PL V++F ++ + ++ +I + +L L P+P + + +P
Sbjct: 309 PLRVLSFDIECAGRKGIFPEPERDPVIQICSL-----GLRWGEPEPFLR--LALTLRPCA 361
Query: 592 CIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRI 651
I KV+ E LL + + +DPD+I G+NI F+L L+ R
Sbjct: 362 PIL-----------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRA 410
Query: 652 NVCKAPHWSKIGRLKR--SNMPKLGGRSG-FGERNATCGRMICDVEISAKELI----RCK 704
K + +GR+ SN+ +S G R+ M+ V++ +++ + +
Sbjct: 411 QTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLR 470
Query: 705 SYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLE-HTWKDAKFILQIMCELNVLP 763
SY L+ + L ++ + I ++ + + Q L + KDA L+++ L VL
Sbjct: 471 SYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLV 530
Query: 764 LALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEI 823
A+++ + G +S L G+ + LL ++P + G ED
Sbjct: 531 NAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMP-------VVKSEGGED--- 580
Query: 824 DGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVA 883
Y G V++P G+YD I LDF+SLYPSI+ N+C+TT+ R
Sbjct: 581 ---------------YTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPG 625
Query: 884 SEAQK--VTEDG--EQEQIPELPDPSLEMGILPREIRKLVERRKQVK-QLMKQQDLNPDL 938
+ AQK +TED E S+ G+LP+ + L+ RK+ K +L K+ D
Sbjct: 626 T-AQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQ 684
Query: 939 ILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQ------ 992
+L D RQ ALK++ANS+YG G + ++ VT GR+++ TK++V+
Sbjct: 685 VL--DGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVE 742
Query: 993 ---KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLY-KLLEIDIDGVFKSLL 1048
+ +V+YGDTDS+M +++ E LG + V+ + + ++ + V+ L
Sbjct: 743 NGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYL 802
Query: 1049 LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTI 1108
L+ KK+YA L+ D + + + KGL+ VRRD C L + + ++L D+ +
Sbjct: 803 LISKKRYAGLLFSSRPDAH--DRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA 860
Query: 1109 VENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQG-GR 1167
V + Q ++ ++L + +SQ I K LT+ DY K++ HV +A + + G
Sbjct: 861 VAHAQ----DVISDLLCNRIDISQLVITKELTRAASDYAGKQA--HVELAERMRKRDPGS 914
Query: 1168 KVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPI 1227
GD V YVI + A ++ P + +L IDTQYYL QQ+ + RI EPI
Sbjct: 915 APSLGDRVPYVIISAAKGVAAYMKSEDP-LFVLEHSLPIDTQYYLEQQLAKPLLRIFEPI 973
Query: 1228 DG---IDAVLI 1235
G +AVL+
Sbjct: 974 LGEGRAEAVLL 984
>gi|153792012 DNA polymerase zeta [Homo sapiens]
Length = 3130
Score = 141 bits (355), Expect = 5e-33
Identities = 147/660 (22%), Positives = 267/660 (40%), Gaps = 64/660 (9%)
Query: 607 VKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLK 666
++V AA E+ L + + DPDI++G+ I LLQR I R+
Sbjct: 2374 LEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVP 2433
Query: 667 RSNMPK--LGGRSGFGERNAT----CGRMICDVEISAKELIRCKSYHLSELVQQILKTER 720
+ R +G + GR+ ++ + + +Y + +L
Sbjct: 2434 DDKIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRF 2493
Query: 721 VVIPMENIQNMYSESSQLLY--LLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSR 778
+ + + + + L +++H + LQ++ +L+++ ++ + G
Sbjct: 2494 PLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLH 2553
Query: 779 TLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAA 838
L G R E ++L NYI + ++ Q + A
Sbjct: 2554 VLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMR---------------------AP 2592
Query: 839 YAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDG----- 893
L+++P+ FY +L+LDF SLYPSI+ +N CF+T K E
Sbjct: 2593 QCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTS 2652
Query: 894 ----------EQEQIPELPD------PSLEMGILPREIRKLVERRKQVKQLMKQQDLNPD 937
+ I P+ PS+ G+LPR + ++++ R VKQ MK +
Sbjct: 2653 LRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA 2712
Query: 938 LILQYDIRQKALKLTANSMYGCLGFSYS-RFYAKPLAALVTYKGREILMHTKEMV---QK 993
L D RQ LKL AN +G ++S R + + +K RE L ++V +K
Sbjct: 2713 LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKK 2772
Query: 994 MNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLY-KLLEIDIDGVFKSLLLLKK 1052
V+YGDTDS+ + E+ FK+G ++ V K +++ + V+ +L K
Sbjct: 2773 WGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTK 2832
Query: 1053 KKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENI 1112
K+Y + E + V + KG++ VRRD C + + + I + +
Sbjct: 2833 KRYVGYMYETLDQKDPVF--DAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYV 2890
Query: 1113 QKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGR-KVKA 1171
Q++ +++ L G + F K + Y +P + + + + R + +
Sbjct: 2891 QRQCMKL----LEGKASIQDFIFAKEY-RGSFSYKPGACVPALELTRKMLTYDRRSEPQV 2945
Query: 1172 GDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGID 1231
G+ V YVI + Q P ++ + L ++ YY+ +QI P +ARI I GID
Sbjct: 2946 GERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSLI-GID 3004
>gi|62198237 DNA-directed DNA polymerase epsilon [Homo sapiens]
Length = 2286
Score = 48.9 bits (115), Expect = 4e-05
Identities = 73/304 (24%), Positives = 128/304 (42%), Gaps = 64/304 (21%)
Query: 942 YDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMN--LEVI 999
YD Q A K NS YG + +R+Y+ +A +V + G I+ +E+++++ LE+
Sbjct: 801 YDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLEL- 859
Query: 1000 YGDTDSI-MINTNSTNLEEVFKLGNKVKSEV------------------NKLYKLLE--- 1037
DTD I + NS VFK N K +V N Y+ L
Sbjct: 860 --DTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPS 917
Query: 1038 -------------IDIDGVFKSLLL--------LKKKKYAALVVEPTSDGNYVTKQELKG 1076
++DG + +++L KK+YA DG+ ELKG
Sbjct: 918 SLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVF----NEDGSLA---ELKG 970
Query: 1077 LDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVL---NGSVPVSQ- 1132
++ RR L K + V L + + + ++ K + + +VL ++P S+
Sbjct: 971 FEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAK-VADYWLDVLYSKAANMPDSEL 1029
Query: 1133 FEI---NKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVK-AGDTVSYVICQDGSNLTA 1188
FE+ N+++++ +DY ++KS G + VK AG + Y+I +
Sbjct: 1030 FELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPV 1089
Query: 1189 SQRA 1192
++RA
Sbjct: 1090 TERA 1093
Score = 33.9 bits (76), Expect = 1.2
Identities = 72/338 (21%), Positives = 119/338 (35%), Gaps = 47/338 (13%)
Query: 510 PVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAK-----NHQNEIIAMAALV 564
PV + + + +PD V + D+ L + +T Q + Q +I +V
Sbjct: 254 PVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIV 313
Query: 565 HHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLA 624
+ PKP ++ FCV ++P E L+ +
Sbjct: 314 SEDIEDFEFTPKPEYEGPFCVFNEP------------------------DEAHLIQRWFE 349
Query: 625 KVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNA 684
V + P I+V +N F+ + R V +IG K S GE A
Sbjct: 350 HVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQ----------GEYKA 399
Query: 685 -TCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLE 743
C M C + + S++L + L + V + E++ M +E Q L
Sbjct: 400 PQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYS 459
Query: 744 HTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIV 803
+ A + L + V P + I L G E LL+ + N I
Sbjct: 460 VSDAVATYYLYMK---YVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIF 516
Query: 804 PDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAG 841
P+KQ + KL D+ +D +T Y G +A +G
Sbjct: 517 PNKQ--EQEFNKLTDDGHVLDSET--YVGGHVEALESG 550
>gi|31543091 MAK16 homolog [Homo sapiens]
Length = 300
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/114 (31%), Positives = 61/114 (53%), Gaps = 18/114 (15%)
Query: 22 RREKKSKKGRQ-------EALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQ 74
RRE+K+ Q E LERLK+ G+ Y + + F E+ + E S + +
Sbjct: 147 RREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDTEEKD 206
Query: 75 DDDWIVDDDGIG---YVEDGREIFDDDLED----DALDA-DEKGKDGKARNKDK 120
DDD D++ +G +VEDG E+ + D+ D D LDA ++ +DGK+ ++++
Sbjct: 207 DDD--DDEEDVGKREFVEDG-EVDESDISDFEDMDKLDASSDEDQDGKSSSEEE 257
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 40.4 bits (93), Expect = 0.013
Identities = 68/283 (24%), Positives = 112/283 (39%), Gaps = 31/283 (10%)
Query: 26 KSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGI 85
K K+GR+ R+ + E E ++ DEE+ + Q + V++DG
Sbjct: 1130 KKKRGRKR--RRINSSVTTETISETTEVLNEPFDNSDEER--PMPQLEPTCEIEVEEDGR 1185
Query: 86 GYVEDGREIFDDDLEDDALDADEKGKDGKA----------RNKDKRNVKKLAVTKPNNIK 135
V R+ F +E+GKD N D N+K+ + P +K
Sbjct: 1186 KPVL--RKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLK 1243
Query: 136 SMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITP--PPVMIL---KKKRSIG-A 189
+ G K +K+ G LN TP TP P + +K+ S G
Sbjct: 1244 CKQVWPKGTKRGLSKWRQNKERKTGF---KLNLYTPPETPMEPDEQVTVEEQKETSEGKT 1300
Query: 190 SPNPFSVHTATAVPSGKIASPV--SRKEPPLTPVPLKRA--EFAGDD-VQVESTEEEQES 244
SP+P + +G+ P +R+E PV + E DD ++ E EEE+E
Sbjct: 1301 SPSPIRIEEEVK-ETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEE 1359
Query: 245 GAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEA 287
E E+ + +E V+ +P AK+ +KE K+++
Sbjct: 1360 EEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDS 1402
>gi|27597090 suppressor of Ty 6 homolog [Homo sapiens]
Length = 1726
Score = 40.0 bits (92), Expect = 0.016
Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 10/122 (8%)
Query: 16 FVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQD 75
FV S A ++ E + R+ K E+ E E+ + ++ ++ + D
Sbjct: 4 FVESEAEESEEEYNDEGEVVPRVTKKFVEEEDDDEEEEEENLDDQDEQGNLKGFINDDDD 63
Query: 76 DDWIVDDDG---------IGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK-RNVKK 125
+D +D+G +G+ + R FDD LEDD D E+ K + K R VKK
Sbjct: 64 EDEGEEDEGSDSGDSEDDVGHKKRKRTSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKK 123
Query: 126 LA 127
++
Sbjct: 124 MS 125
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 39.7 bits (91), Expect = 0.022
Identities = 34/136 (25%), Positives = 55/136 (40%), Gaps = 25/136 (18%)
Query: 171 PQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPV--------P 222
P PPV ++ + A+P P P + PV+ P L P P
Sbjct: 816 PPTASPPVPAKEEPEELPAAPGPLP---PPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPP 872
Query: 223 LKRAEF------AGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKE 276
+ + D+ + E EEE+E E E+ DF+E E EE + +++E
Sbjct: 873 ALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEE--------EYFEEE 924
Query: 277 SEPAEEVKQEADSGKG 292
E EE ++E + +G
Sbjct: 925 EEEEEEFEEEFEEEEG 940
Score = 33.5 bits (75), Expect = 1.5
Identities = 18/54 (33%), Positives = 30/54 (55%)
Query: 231 DDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVK 284
+D + E +EE+ E E+ +F+E E EE +LE + ++E E EEV+
Sbjct: 908 EDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVE 961
>gi|21327710 nucleosome assembly protein 1-like 3 [Homo sapiens]
Length = 506
Score = 38.1 bits (87), Expect = 0.063
Identities = 34/127 (26%), Positives = 51/127 (40%), Gaps = 12/127 (9%)
Query: 222 PLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAE 281
PL F + + E TEEE E + ED +F EV++ M ++E P E
Sbjct: 142 PLYDRRFQIINAEYEPTEEECEWNS---EDEEFSSDEEVQDNTPSEMPPLEGEEEENPKE 198
Query: 282 ---------EVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLV 332
EV +E K + +P+V + D + EV+ D +P V
Sbjct: 199 NPEVKAEEKEVPKEIPEVKDEEKEVPKEIPEVKAEEKADSKDCMEATPEVKEDPKEVPQV 258
Query: 333 KGADEEQ 339
K D+EQ
Sbjct: 259 KADDKEQ 265
>gi|156071450 nardilysin isoform a [Homo sapiens]
Length = 1219
Score = 37.7 bits (86), Expect = 0.082
Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 62 DEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLE-DDALDADEKGKDGKARNKDK 120
D+E+ ++ + +DDD +D G +D E FDD+ E DD D D +D + ++
Sbjct: 142 DDEEEEEVEEEEEDDD---EDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEE 198
Query: 121 RNVKKLAVTKPNNIKSMFI 139
R + T+ ++S+F+
Sbjct: 199 RAEARKKTTEKQQLQSLFL 217
>gi|13376429 hypothetical protein LOC80011 [Homo sapiens]
Length = 254
Score = 37.7 bits (86), Expect = 0.082
Identities = 32/129 (24%), Positives = 63/129 (48%), Gaps = 6/129 (4%)
Query: 6 GDD-SLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEE 64
GDD +L FVS E++ K RQE E+++K + E+ EV D +YE + E+
Sbjct: 4 GDDGNLIIKKRFVSEAELDERR--KRRQEEWEKVRKPEDPEECPEEVYDPRSLYERLQEQ 61
Query: 65 QYSKLVQARQDDDWIVDDDGIGYVEDGREIFDD-DLEDDALDADEKGKDGKARNKDKRNV 123
+ K Q ++ + + G ED D+ + + ++ + ++ K + + N+
Sbjct: 62 KDRK--QQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEKQRREEELKELKEYRNNL 119
Query: 124 KKLAVTKPN 132
KK+ +++ N
Sbjct: 120 KKVGISQEN 128
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 37.4 bits (85), Expect = 0.11
Identities = 55/222 (24%), Positives = 104/222 (46%), Gaps = 27/222 (12%)
Query: 879 VQRVASEAQKVTEDGE--QEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDL-N 935
+Q++ SE Q + + + Q+ + EL S + L +E + L + Q+++ KQ + N
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 936 PDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVT--YKGREILMHTKEMVQK 993
L Q +I+ L+ N G L ++ +K + + +E+ KE+V++
Sbjct: 839 KRLRQQAEIKDTTLEEN-NVKIGNLE-KENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 994 MNLEV-----IYGDTDSIMINTNSTNLE------EVFKLG-NKVK------SEVNKLYKL 1035
+++ + D S + T N + E+ K+G NK + S + YKL
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 1036 LEIDIDGVFKSLLLLKKKKYAALV--VEPTSDGNYVTKQELK 1075
LE ++ K L +K++K AAL +E +++ N +QELK
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 37.4 bits (85), Expect = 0.11
Identities = 54/221 (24%), Positives = 103/221 (46%), Gaps = 26/221 (11%)
Query: 879 VQRVASEAQKVTEDGE--QEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDL-N 935
+Q++ SE Q + + + Q+ + EL S + L +E + L + Q+++ KQ + N
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 936 PDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVT--YKGREILMHTKEMVQK 993
L Q +I+ L+ N G L ++ +K + + +E+ KE+V++
Sbjct: 839 KRLRQQAEIKDTTLEEN-NVKIGNLE-KENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 994 MNLEV-----IYGDTDSIMINTNSTNLE------EVFKLG-NKVK-----SEVNKLYKLL 1036
+++ + D S + T N + E+ K+G NK + + YKLL
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 1037 EIDIDGVFKSLLLLKKKKYAALV--VEPTSDGNYVTKQELK 1075
E ++ K L +K++K AAL +E +++ N +QELK
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 997
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 37.4 bits (85), Expect = 0.11
Identities = 52/210 (24%), Positives = 81/210 (38%), Gaps = 30/210 (14%)
Query: 151 VDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASP 210
VD++KD L + + + P +++K+R + P P I +
Sbjct: 848 VDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGP--------AESPDEGITTT 899
Query: 211 VSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEV-----DL 265
E TP L+ E G D +E E+E E GD++E E EE D
Sbjct: 900 EGEGECEQTPEELEPVEKQGVD-DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDG 958
Query: 266 EPMAAKAWDKES--EPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQ 323
E + K S E E K EAD +Y+ V+ D E D ++++ +
Sbjct: 959 EEHVCVSASKHSPTEDEESAKAEAD------AYIREKRESVASGDDRAEEDMDEAIEKGE 1012
Query: 324 VDSSHLPLVKGADEEQVFHFYWLDAYEDQY 353
+ S + ADEE DA E++Y
Sbjct: 1013 AEQSE----EEADEEDKAE----DAREEEY 1034
Score = 32.7 bits (73), Expect = 2.6
Identities = 43/149 (28%), Positives = 64/149 (42%), Gaps = 26/149 (17%)
Query: 162 ILQDLNTETPQIT-------PPPV-----MILKKKRSIGASPNPFSVHTATAVPSGKIAS 209
+ ++ ETP++T PP V +++KK + I P SV T VPS + S
Sbjct: 557 VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKP-SV-TEKEVPSKEEPS 614
Query: 210 PVSRK--EPPLTPVPLKRAEFAG----DDVQVESTEEEQESGAMEFEDGDFDEPMEVEEV 263
PV + E T V K A+ V+ E +EE+E E + P++ EE
Sbjct: 615 PVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEK 674
Query: 264 DLEPMAAKAWDKE------SEPAEEVKQE 286
+ K KE EP +EVK+E
Sbjct: 675 PKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 37.0 bits (84), Expect = 0.14
Identities = 32/115 (27%), Positives = 59/115 (51%), Gaps = 8/115 (6%)
Query: 17 VSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDD 76
V++ + E++ +K +E + +K +AG++ K E + G + D+ K A++ +
Sbjct: 119 VAAEVKNEEEDQKEDEED-QNEEKGEAGKEDKDEKGEEDG---KEDKNGNEKGEDAKEKE 174
Query: 77 DWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGK---DGKARNKDKRNVKKLAV 128
D +DG G EDG+E +D+ E++ GK DGK + DK+ K + V
Sbjct: 175 DGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKG-DKKEGKDVKV 228
>gi|42542392 CCAAT/enhancer binding protein zeta [Homo sapiens]
Length = 1054
Score = 37.0 bits (84), Expect = 0.14
Identities = 36/162 (22%), Positives = 66/162 (40%), Gaps = 28/162 (17%)
Query: 39 KKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIV----DDDGIGYVEDGREI 94
KK EK K + ++ + E+VD+E++ +L+ +DD+ D D G V+ +
Sbjct: 819 KKVAVKEKQKRDADEES--IEDVDDEEFEELIDTFEDDNCFSSGKDDMDFAGNVKKRTK- 875
Query: 95 FDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLS 154
+D+ LD D +G D + N D V G ++ ++
Sbjct: 876 ---GAKDNTLDEDSEGSDDELGNLDDDEVS-----------------LGSMDDEEFAEVD 915
Query: 155 KD-GLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFS 195
+D G D+L D + P++ + KK + G F+
Sbjct: 916 EDGGTFMDVLDDESESVPELEVHSKVSTKKSKRKGTDDFDFA 957
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 37.0 bits (84), Expect = 0.14
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 6/129 (4%)
Query: 7 DDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEV------EDFTGVYEE 60
D ++++ V + KK ++ R LE L E+ + +D EE
Sbjct: 174 DKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEE 233
Query: 61 VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK 120
+ Q + + + +D +DDG ++ + DDD +DD + DE +DG+ N+ +
Sbjct: 234 TTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKR 293
Query: 121 RNVKKLAVT 129
+++ T
Sbjct: 294 YYLRQRKAT 302
>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
Length = 2964
Score = 37.0 bits (84), Expect = 0.14
Identities = 31/121 (25%), Positives = 49/121 (40%), Gaps = 7/121 (5%)
Query: 163 LQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVP 222
LQ + P I P + I K+ + SP P P ++ SPV K P L+ P
Sbjct: 857 LQSKEEQEPPILQPEIEIPSFKQGLSVSPFP----KKRGRPKRQMRSPVKMKPPVLSVAP 912
Query: 223 LKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEE 282
E + ++ ES S E ED +P ++++ P D E EP ++
Sbjct: 913 FVATE-SPSKLESESDNHRSSSDFFESED-QLQDPDDLDD-SHRPSVCSMSDLEMEPDKK 969
Query: 283 V 283
+
Sbjct: 970 I 970
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 37.0 bits (84), Expect = 0.14
Identities = 59/298 (19%), Positives = 119/298 (39%), Gaps = 47/298 (15%)
Query: 20 RARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWI 79
+ +++KK KKG +E E+ KK + +++ +E +E Q R++++ I
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ------KREEEERI 366
Query: 80 VDDDGIGYVEDGREIFDDDLEDDALDADEKGKD-----GKARNKDKRNVKKLAVTKPNNI 134
+ + E + + + +++ K+ GK K +R + A +
Sbjct: 367 KRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426
Query: 135 KSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTET--------------------PQIT 174
++ + K + K + +D I Q L ++ + T
Sbjct: 427 QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEET 486
Query: 175 PPPVMILKKKRSIGASPNPF----SVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAG 230
PPPV +++ + A + + S V K+ V KE P + E
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV--KENPEE----EEEEEEE 540
Query: 231 DDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEAD 288
++ ES EEE+E G E +GD ++ E+V E + K DK +P++E+ +++
Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEED----EKVSDEKDSGKTLDK--KPSKEMSSDSE 592
Score = 34.3 bits (77), Expect = 0.90
Identities = 29/121 (23%), Positives = 50/121 (41%), Gaps = 8/121 (6%)
Query: 7 DDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQY 66
DD+ + +A ++++ +K R E +L+K K E+ + +D + +E
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD-----QSKQKESQ 273
Query: 67 SKLVQARQDDDWIVDDDGIGYVEDGREI---FDDDLEDDALDADEKGKDGKARNKDKRNV 123
K + VD I E+ E +DD E D D+K K G+ K+K
Sbjct: 274 RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
Query: 124 K 124
K
Sbjct: 334 K 334
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 36.6 bits (83), Expect = 0.18
Identities = 60/283 (21%), Positives = 112/283 (39%), Gaps = 35/283 (12%)
Query: 28 KKGRQEALERLKKAKA---GEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDG 84
K +EAL + + A E+ K E+ E +EE +K + + +++G
Sbjct: 466 KSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG 525
Query: 85 IGYVEDGREIFDDDLEDDALD-ADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAG 143
E+G+E +++ E D A+E G + + ++ + ++ T+ A
Sbjct: 526 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 585
Query: 144 KKTADKAVDL-SKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASP----------- 191
KK +K+ ++ +K+ L+ D + + P + K K + SP
Sbjct: 586 KKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 645
Query: 192 NPFSVHTATAVPSGKI----ASPVSR---KEPPLTPVPLKRAEFAGDDVQVESTEEEQES 244
+P + VP + SPVS+ +E +PVP E A +V E+++E
Sbjct: 646 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE- 704
Query: 245 GAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEA 287
E EV+E E K +K + E+ K E+
Sbjct: 705 -----------EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 736
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 36.6 bits (83), Expect = 0.18
Identities = 60/283 (21%), Positives = 112/283 (39%), Gaps = 35/283 (12%)
Query: 28 KKGRQEALERLKKAKA---GEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDG 84
K +EAL + + A E+ K E+ E +EE +K + + +++G
Sbjct: 90 KSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG 149
Query: 85 IGYVEDGREIFDDDLEDDALD-ADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAG 143
E+G+E +++ E D A+E G + + ++ + ++ T+ A
Sbjct: 150 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 209
Query: 144 KKTADKAVDL-SKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASP----------- 191
KK +K+ ++ +K+ L+ D + + P + K K + SP
Sbjct: 210 KKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 269
Query: 192 NPFSVHTATAVPSGKI----ASPVSR---KEPPLTPVPLKRAEFAGDDVQVESTEEEQES 244
+P + VP + SPVS+ +E +PVP E A +V E+++E
Sbjct: 270 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE- 328
Query: 245 GAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEA 287
E EV+E E K +K + E+ K E+
Sbjct: 329 -----------EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
>gi|6857816 E74-like factor 2 (ets domain transcription factor)
isoform 2 [Homo sapiens]
Length = 533
Score = 36.6 bits (83), Expect = 0.18
Identities = 28/102 (27%), Positives = 42/102 (41%), Gaps = 6/102 (5%)
Query: 209 SPVSRKEPPLTPVP-----LKRAEFAGDDVQVESTEEEQESGAMEFEDG-DFDEPMEVEE 262
SPV PP P R + + V STEE + D EPM+ ++
Sbjct: 56 SPVEVFVPPCVSTPEFIHAAMRPDVITETVVEVSTEESEPMDTSPIPTSPDSHEPMKKKK 115
Query: 263 VDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDV 304
V +P ++ P +K++ GKG +YL FL D+
Sbjct: 116 VGRKPKTQQSPISNGSPELGIKKKPREGKGNTTYLWEFLLDL 157
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 36.6 bits (83), Expect = 0.18
Identities = 34/138 (24%), Positives = 60/138 (43%), Gaps = 22/138 (15%)
Query: 4 VHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKK------AKAGEKYKYEVEDFTGV 57
V GDD +F+ ARRE++ +K QEALER K+ + +++ T
Sbjct: 82 VEGDDE----AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 58 YEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARN 117
E ++E+ S+ Q R + +E+ + ++D DA+E K+ K +
Sbjct: 138 NETTEKEEKSESRQERYE------------IEETETVTKSYQKNDWRDAEENKKEDKEKE 185
Query: 118 KDKRNVKKLAVTKPNNIK 135
+++ K N IK
Sbjct: 186 EEEEEKPKRGSIGENQIK 203
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 36.6 bits (83), Expect = 0.18
Identities = 34/138 (24%), Positives = 60/138 (43%), Gaps = 22/138 (15%)
Query: 4 VHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKK------AKAGEKYKYEVEDFTGV 57
V GDD +F+ ARRE++ +K QEALER K+ + +++ T
Sbjct: 88 VEGDDE----AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 58 YEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARN 117
E ++E+ S+ Q R + +E+ + ++D DA+E K+ K +
Sbjct: 144 NETTEKEEKSESRQERYE------------IEETETVTKSYQKNDWRDAEENKKEDKEKE 191
Query: 118 KDKRNVKKLAVTKPNNIK 135
+++ K N IK
Sbjct: 192 EEEEEKPKRGSIGENQIK 209
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 35.8 bits (81), Expect = 0.31
Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 22/140 (15%)
Query: 4 VHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKK------AKAGEKYKYEVEDFTGV 57
V GDD +F+ ARRE++ +K QEALER K+ + +++ T
Sbjct: 88 VEGDDE----AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 58 YEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARN 117
E ++E+ S+ Q R + +E+ + ++D DA+E K+ K +
Sbjct: 144 NETTEKEEKSESRQERYE------------IEETETVTKSYQKNDWRDAEENKKEDKEKE 191
Query: 118 KDKRNVKKLAVTKPNNIKSM 137
+++ K N ++ M
Sbjct: 192 EEEEEKPKRGSIGENQVEVM 211
>gi|210147567 hypothetical protein LOC220081 [Homo sapiens]
Length = 696
Score = 35.8 bits (81), Expect = 0.31
Identities = 66/267 (24%), Positives = 111/267 (41%), Gaps = 40/267 (14%)
Query: 24 EKKSKKGRQEALERLKKAK-AGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDD 82
E K G E E +++ + G++ E E++ G E ++EE+Y + +D+I +
Sbjct: 96 EYLEKAGYLEEEEYIEEEEYLGKEGYLEEEEYLGKEEHLEEEEYLGKEGYLEKEDYIEEV 155
Query: 83 DGIG---YVED----GREIFDDDLEDDALDADEKGKDGKARNKD-----KRNVKKLAVTK 130
D +G Y+E+ G++ + + E+ AL+ +E ++ +A K+ K N+ K + +
Sbjct: 156 DYLGKKAYLEEEEYLGKKSYLE--EEKALEKEENLEEEEALEKEENLDGKENLYKKYLKE 213
Query: 131 PNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPV---------MIL 181
P A +T S D + L TP PV ++L
Sbjct: 214 PK-------ASYSSQTMLLRDARSPDAGPSQVTTFLTVPLTFATPSPVSESATESSELLL 266
Query: 182 KKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEE 241
R AS + + TAV S K S ++ T L E VQ + E
Sbjct: 267 TLYRRSQASQTDW-CYDRTAVKSLKSKSETEQE----TTTKLAPEEHVNTKVQQKKEENV 321
Query: 242 QESGAME-FEDGDFDE---PMEVEEVD 264
E + E F DG DE +EVE++D
Sbjct: 322 LEFASKENFWDGITDESIDKLEVEDLD 348
>gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
Length = 895
Score = 35.8 bits (81), Expect = 0.31
Identities = 20/86 (23%), Positives = 37/86 (43%), Gaps = 7/86 (8%)
Query: 98 DLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDG 157
+ E+D + +K K+ K RN+ K+ KP ++ + +G + D D
Sbjct: 310 ETEEDTVSVSKKEKNRKRRNRKKKK-------KPQRVRGVSSESSGDREKDSTRSRGSDS 362
Query: 158 LLGDILQDLNTETPQITPPPVMILKK 183
D+ + TE P+I P + K+
Sbjct: 363 PAADVEIEYVTEEPEIYEPNFIFFKR 388
>gi|19923844 coiled-coil domain containing 82 [Homo sapiens]
Length = 544
Score = 35.4 bits (80), Expect = 0.41
Identities = 32/138 (23%), Positives = 64/138 (46%), Gaps = 30/138 (21%)
Query: 10 LSDSGSFVSSRARREKKSKKG-RQEALERLK---------KAKAGEKYKYEVEDFTGVYE 59
+ D GS V + +K+ ++E L++LK + +G ++ ++ +
Sbjct: 214 VEDEGSSVEMEQKTPEKTLAAQKREKLQKLKELSKQRSRQRRSSGRDFEDSEKESCPSSD 273
Query: 60 EVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKG-KDGKARNK 118
EVDEE+ ++D++ D+DG DD + DD + DE+G ++ K +
Sbjct: 274 EVDEEE--------EEDNYESDEDG-----------DDYIIDDFVVQDEEGDEENKNQQG 314
Query: 119 DKRNVKKLAVTKPNNIKS 136
+K +L + K N++ S
Sbjct: 315 EKLTTSQLKLVKQNSLYS 332
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 35.0 bits (79), Expect = 0.53
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 202 VPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESG-AMEFEDGDFDEPMEV 260
+P+G+ S L V + +D E+ EEE++S E EDG E E
Sbjct: 232 IPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAEN 291
Query: 261 EEVDLEPMAAKAWDKESE-----PAEEVKQEADSGKGTVS 295
EE + + A+ D+E E P E K+E S GT +
Sbjct: 292 EEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTA 331
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 35.0 bits (79), Expect = 0.53
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 202 VPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESG-AMEFEDGDFDEPMEV 260
+P+G+ S L V + +D E+ EEE++S E EDG E E
Sbjct: 232 IPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAEN 291
Query: 261 EEVDLEPMAAKAWDKESE-----PAEEVKQEADSGKGTVS 295
EE + + A+ D+E E P E K+E S GT +
Sbjct: 292 EEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTA 331
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,264,163
Number of Sequences: 37866
Number of extensions: 2686060
Number of successful extensions: 9915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 9469
Number of HSP's gapped (non-prelim): 528
length of query: 1462
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1347
effective length of database: 13,892,928
effective search space: 18713774016
effective search space used: 18713774016
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.