Search of human proteins with 105990526

Search of human proteins with 105990526

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
isoform b [Homo sapiens]
         (308 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i...   616   e-177
gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i...   603   e-173
gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho...   286   1e-77
gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ...   206   2e-53
gi|5031763 hairy and enhancer of split 1 [Homo sapiens]                91   1e-18
gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]     88   1e-17
gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]    85   9e-17
gi|71274142 HES/HEY-like transcription factor [Homo sapiens]           82   5e-16
gi|145207994 hairy and enhancer of split 7 [Homo sapiens]              69   4e-12
gi|13540521 basic helix-loop-helix domain containing, class B, 3...    65   8e-11
gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]     64   2e-10
gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]    63   3e-10
gi|58219048 hairy and enhancer of split 5 [Homo sapiens]               62   8e-10
gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]       60   2e-09
gi|24586667 transcription factor-like protein 4 isoform gamma [H...    53   3e-07
gi|38201612 transcription factor-like protein 4 isoform beta [Ho...    53   4e-07
gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]    47   2e-05
gi|38201614 transcription factor-like protein 4 isoform alpha [H...    47   2e-05
gi|66912172 hairy and enhancer of split 3 [Homo sapiens]               47   2e-05
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...    45   1e-04
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...    45   1e-04
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...    44   2e-04
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...    40   0.003
gi|66529407 tensin [Homo sapiens]                                      39   0.004
gi|52630419 sterol regulatory element binding transcription fact...    39   0.008
gi|22547195 sterol regulatory element binding transcription fact...    39   0.008
gi|24307933 transcription factor EB [Homo sapiens]                     37   0.029
gi|8659574 transcription factor E3 [Homo sapiens]                      36   0.038
gi|27477113 sterol regulatory element-binding transcription fact...    36   0.049
gi|4557755 microphthalmia-associated transcription factor isofor...    35   0.064

>gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
           isoform b [Homo sapiens]
          Length = 308

 Score =  616 bits (1588), Expect = e-177
 Identities = 308/308 (100%), Positives = 308/308 (100%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
Sbjct: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60

Query: 61  RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 120
           RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH
Sbjct: 61  RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 120

Query: 121 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 180
           ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG
Sbjct: 121 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 180

Query: 181 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 240
           HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS
Sbjct: 181 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 240

Query: 241 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 300
           LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP
Sbjct: 241 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 300

Query: 301 WGTEIGAF 308
           WGTEIGAF
Sbjct: 301 WGTEIGAF 308


>gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
           isoform a [Homo sapiens]
          Length = 304

 Score =  603 bits (1554), Expect = e-173
 Identities = 304/308 (98%), Positives = 304/308 (98%), Gaps = 4/308 (1%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
Sbjct: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60

Query: 61  RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 120
           RRDRINNSLSELRRLVPSAFEKQ    GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH
Sbjct: 61  RRDRINNSLSELRRLVPSAFEKQ----GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 116

Query: 121 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 180
           ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG
Sbjct: 117 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 176

Query: 181 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 240
           HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS
Sbjct: 177 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 236

Query: 241 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 300
           LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP
Sbjct: 237 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 296

Query: 301 WGTEIGAF 308
           WGTEIGAF
Sbjct: 297 WGTEIGAF 304


>gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo
           sapiens]
          Length = 337

 Score =  286 bits (733), Expect = 1e-77
 Identities = 182/340 (53%), Positives = 220/340 (64%), Gaps = 46/340 (13%)

Query: 7   EYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRIN 66
           E ++S+S++DETI+V  E+     + SS +   SPTT+SQI+ARK+RRGIIEKRRRDRIN
Sbjct: 6   EETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRIN 65

Query: 67  NSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDY 126
           NSLSELRRLVP+AFEKQ    GSAKLEKAEILQMTVDHLKML   GGKGYFDAHALAMD+
Sbjct: 66  NSLSELRRLVPTAFEKQ----GSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDF 121

Query: 127 RSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGA------HAGLG 180
            S+GFRECL EVARYLS +EGLD+SDPLRVRLVSHL+  A+QREAA+        H  L 
Sbjct: 122 MSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPLH 181

Query: 181 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGT-----TASPTEPHHQGRLGS---AHPEAPA 232
              W   F H P     LL P   H +  T     T S   P H   L +   AH ++ A
Sbjct: 182 PHHWAAAFHHLP---AALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADS-A 237

Query: 233 LRAPPSGSLGP-VLPVVTSASKLSPPLLSSVASLSA----FPFSF-GSFHLLSPN----- 281
           LR P +GS+ P V P+ TS   LS  + ++ A+ +A    FP SF G+F +L PN     
Sbjct: 238 LRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAV 297

Query: 282 ----ALSP-------SAP--TQAANLGKPYRPWGTEIGAF 308
               A+SP       S+P  T +    KPYRPWGTE+GAF
Sbjct: 298 AAATAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF 337


>gi|7657154 hairy/enhancer-of-split related with YRPW motif-like
           [Homo sapiens]
          Length = 328

 Score =  206 bits (524), Expect = 2e-53
 Identities = 153/349 (43%), Positives = 195/349 (55%), Gaps = 62/349 (17%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKR   E S SD E D  I+V +E     G LS     +S  +SSQ+ ARK+RRGIIEKR
Sbjct: 1   MKRPK-EPSGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQARKKRRGIIEKR 54

Query: 61  RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 120
           RRDRIN+SLSELRRLVP+AFEKQ    GS+KLEKAE+LQMTVDHLKMLH  GG G+FDA 
Sbjct: 55  RRDRINSSLSELRRLVPTAFEKQ----GSSKLEKAEVLQMTVDHLKMLHATGGTGFFDAR 110

Query: 121 ALAMDYRSLGFRECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHAGL 179
           ALA+D+RS+GFRECL EV RYL ++EG  + +DP+R+RL+SHLN+YA++ E +      L
Sbjct: 111 ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPL 170

Query: 180 GHIPWGTVFGHH----PHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALR- 234
               W   F H     P +++ L +        G   SP  P   G    A+P  PALR 
Sbjct: 171 AFPAWPWSFFHSCPGLPALSNQLAI-------LGRVPSPVLP---GVSSPAYP-IPALRT 219

Query: 235 APPSGSLGPVLPV--------VTSASKLSPPLLSSVASLSAFPFSFG--SFH---LLSPN 281
           AP   + G +LP           S+++ + PL      +   P S    S H   LL  +
Sbjct: 220 APLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSS 279

Query: 282 ALSPSAPTQAA--------------NLGKP-----YRPWG---TEIGAF 308
           + +P  PT +A                G+P     Y  W    TEIGAF
Sbjct: 280 SPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF 328


>gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
          Length = 280

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 91/285 (31%), Positives = 126/285 (44%), Gaps = 58/285 (20%)

Query: 41  PTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQM 100
           P T+S+   RK  + I+EKRRR RIN SLS+L+ L+  A +K       +KLEKA+IL+M
Sbjct: 28  PKTASE--HRKSSKPIMEKRRRARINESLSQLKTLILDALKKD--SSRHSKLEKADILEM 83

Query: 101 TVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVS 160
           TV HL+ L  A            +     GF EC+ EV R+LS  EG++    +R RL+ 
Sbjct: 84  TVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE--VRTRLLG 141

Query: 161 HLNNYASQREAASGAHAGLGHI-----------PWGTVFGHHPHIAHPLLLPQNGHGNAG 209
           HL N  +Q  A +  + G  H            P G    H P    P L+P  G     
Sbjct: 142 HLANCMTQINAMT--YPGQPHPALQAPPPPPPGPGGP--QHAPFAPPPPLVPIPGGAAPP 197

Query: 210 TTASPTEPHHQ-GRLGSAHPEAPALRAP--------PSGSL---GPVLPVVTSASKLSPP 257
              +P +   Q G           + AP        P+G+    GPV+PV TS S  S  
Sbjct: 198 PGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTS-- 255

Query: 258 LLSSVASLSAFPFSFGSFHLLSPNALSPSA-PTQAANLGKPYRPW 301
                               + PNA+SPS+ P+  A+    +RPW
Sbjct: 256 --------------------VGPNAVSPSSGPSLTAD--SMWRPW 278


>gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]
          Length = 221

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 75/201 (37%), Positives = 95/201 (47%), Gaps = 21/201 (10%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           RK  + ++EKRRR RIN SL++L+ L+  A  K+      +KLEKA+IL+MTV HL+ L 
Sbjct: 35  RKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRH--SKLEKADILEMTVRHLRSLR 92

Query: 110 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNY 165
                    A    +     GF ECLAEV R+L+  EG+ A   +R RL+ H    L   
Sbjct: 93  RVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQL 150

Query: 166 ASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGS 225
              R  AS + A     P   V+   P      LLP  G G     A P  P     L  
Sbjct: 151 GPSRRPASLSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTR 199

Query: 226 AHPEAPALRAPPSGSLGPVLP 246
           A P AP  RA P G  GP  P
Sbjct: 200 ALPAAP--RAGPQGPGGPWRP 218


>gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]
          Length = 247

 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 73/195 (37%), Positives = 92/195 (47%), Gaps = 21/195 (10%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKG 115
           ++EKRRR RIN SL++L+ L+  A  K+      +KLEKA+IL+MTV HL+ L       
Sbjct: 67  VMEKRRRARINESLAQLKTLILDALRKESSRH--SKLEKADILEMTVRHLRSLRRVQVTA 124

Query: 116 YFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNYASQREA 171
              A    +     GF ECLAEV R+L+  EG+ A   +R RL+ H    L      R  
Sbjct: 125 ALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQLGPSRRP 182

Query: 172 ASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAP 231
           AS + A     P   V+   P      LLP  G G     A P  P     L  A P AP
Sbjct: 183 ASLSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTRALPAAP 231

Query: 232 ALRAPPSGSLGPVLP 246
             RA P G  GP  P
Sbjct: 232 --RAGPQGPGGPWRP 244


>gi|71274142 HES/HEY-like transcription factor [Homo sapiens]
          Length = 327

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 83/275 (30%), Positives = 114/275 (41%), Gaps = 56/275 (20%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQ-------------------------------- 83
           +IEKRRRDRIN  L+EL + VP A  KQ                                
Sbjct: 61  VIEKRRRDRINRCLNELGKTVPMALAKQGEPQEALAQIRSRVRSLVLSSATVPDQQALGR 120

Query: 84  -----VMEQGSAKLEKAEILQMTVDHLKMLHTAG-GKGYFDAHALA--MDYRSLGFRECL 135
                ++ Q S KLEKAEIL+MTV +L+ LH+A   +G   A  LA   +Y   G+ EC+
Sbjct: 121 CEGPFLLLQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYHECM 180

Query: 136 AEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIA 195
             +  YL+ +E ++  D    R+++ L + A  R  A  A   LG +P    F +  H A
Sbjct: 181 KNLVHYLTTVERMETKDTKYARILAFLQSKA--RLGAEPAFPPLGSLP-EPDFSYQLHPA 237

Query: 196 HPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPV-VTSASKL 254
            P      GH        P     QG      P  P     P+    P  PV + S ++ 
Sbjct: 238 GPEFA---GHSPGEAAVFP-----QGSGAGPFPWPPGAARSPALPYLPSAPVPLASPAQQ 289

Query: 255 SPPLLSSVASLSAFPFS-FGSFHLLSPNALSPSAP 288
             P L+ V  L     +  G  H   PNAL+   P
Sbjct: 290 HSPFLTPVQGLDRHYLNLIGHAH---PNALNLHTP 321


>gi|145207994 hairy and enhancer of split 7 [Homo sapiens]
          Length = 225

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 68/212 (32%), Positives = 87/212 (41%), Gaps = 27/212 (12%)

Query: 51  KRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHT 110
           K  + ++EKRRRDRIN SL ELR L+      Q +   + KLEKAEIL+  V +L+    
Sbjct: 14  KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLR--NPKLEKAEILEFAVGYLRERSR 71

Query: 111 AGGKG-----YFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNY 165
               G       DA ALA  Y S GFRECL  +A +       DAS   R +L S L+ Y
Sbjct: 72  VEPPGVPRSPVQDAEALASCYLS-GFRECLLRLAAFAH-----DASPAARAQLFSALHGY 125

Query: 166 ASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGS 225
              +             P        P    P L P       G       P HQG    
Sbjct: 126 LRPKP------------PRPKPVDPRPPAPRPSLDP--AAPALGPALHQRPPVHQGHPSP 171

Query: 226 AHPEAPALRAPPSGSLGPVLPVVTSASKLSPP 257
               +P+L +P +G  G   P+        PP
Sbjct: 172 RCAWSPSLCSPRAGDSGAPAPLTGLLPPPPPP 203


>gi|13540521 basic helix-loop-helix domain containing, class B, 3
           [Homo sapiens]
          Length = 482

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 17/126 (13%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKG 115
           +IEK+RRDRIN  +++L+ L+P   +   +      LEKA +L++T+ HLK L     + 
Sbjct: 51  LIEKKRRDRINECIAQLKDLLPEHLKLTTL----GHLEKAVVLELTLKHLKALTALTEQQ 106

Query: 116 YFDAHALAMDYRSL-------------GFRECLAEVARYLSIIEGLDASDPLRVRLVSHL 162
           +    AL    RSL             GF+ C  EV +YLS  E     +P  V+L++HL
Sbjct: 107 HQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHL 166

Query: 163 NNYASQ 168
           +  A+Q
Sbjct: 167 HAVATQ 172


>gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]
          Length = 224

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 58/198 (29%), Positives = 89/198 (44%), Gaps = 18/198 (9%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           RK R+ ++EK+RR RIN SL ELR L+  A       +  AKLE AE+L++TV  ++ + 
Sbjct: 26  RKARKPLVEKKRRARINESLQELRLLLAGA-------EVQAKLENAEVLELTVRRVQGVL 78

Query: 110 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQR 169
               +      A A +  + G+ +C+ EV  ++S  + +DA+  +   L++HL      R
Sbjct: 79  RGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLR 136

Query: 170 EAAS------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRL 223
           E +S       A AG    P  + +        P+  P    G      S  E   +  L
Sbjct: 137 EGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAEL 193

Query: 224 GSAHPEAPALRAPPSGSL 241
             A  E P L     GSL
Sbjct: 194 SQAPAEGPDLVPAALGSL 211


>gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]
          Length = 222

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 58/198 (29%), Positives = 88/198 (44%), Gaps = 20/198 (10%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           RK R+ ++EK+RR RIN SL ELR L+  A          AKLE AE+L++TV  ++ + 
Sbjct: 26  RKARKPLVEKKRRARINESLQELRLLLAGA---------EAKLENAEVLELTVRRVQGVL 76

Query: 110 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQR 169
               +      A A +  + G+ +C+ EV  ++S  + +DA+  +   L++HL      R
Sbjct: 77  RGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLR 134

Query: 170 EAAS------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRL 223
           E +S       A AG    P  + +        P+  P    G      S  E   +  L
Sbjct: 135 EGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAEL 191

Query: 224 GSAHPEAPALRAPPSGSL 241
             A  E P L     GSL
Sbjct: 192 SQAPAEGPDLVPAALGSL 209


>gi|58219048 hairy and enhancer of split 5 [Homo sapiens]
          Length = 166

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 44/128 (34%), Positives = 75/128 (58%), Gaps = 15/128 (11%)

Query: 39  MSPTTSS-QILARKR----RRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLE 93
           M+P+T + ++L+ K     R+ ++EK RRDRIN+S+ +L+ L+   F +    Q ++KLE
Sbjct: 1   MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFAR---HQPNSKLE 57

Query: 94  KAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDP 153
           KA+IL+M V +LK  H+          +L  DY S G+  CL E  ++L+    L A+  
Sbjct: 58  KADILEMAVSYLK--HSKAFVAAAGPKSLHQDY-SEGYSWCLQEAVQFLT----LHAASD 110

Query: 154 LRVRLVSH 161
            +++L+ H
Sbjct: 111 TQMKLLYH 118


>gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]
          Length = 173

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 40/196 (20%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           RK  + ++EKRRR RIN SLS+L+ L+     ++      +KLEKA++L+MTV  L+ L 
Sbjct: 14  RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRE--NSNCSKLEKADVLEMTVRFLQELP 71

Query: 110 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQR 169
            +    +  A  L  D    G+  C+A +AR L     L+ +  +  RL+ HL      R
Sbjct: 72  AS---SWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPA--VSARLLEHL-----WR 121

Query: 170 EAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPE 229
            AAS    G                           G AG ++ P+ P       +  P 
Sbjct: 122 RAASATLDG---------------------------GRAGDSSGPSAP-APAPASAPEPA 153

Query: 230 APALRAPPSGSLGPVL 245
           +  + +PPS   GP L
Sbjct: 154 SAPVPSPPSPPCGPGL 169


>gi|24586667 transcription factor-like protein 4 isoform gamma [Homo
           sapiens]
          Length = 298

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 24/146 (16%)

Query: 4   AHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQIL--------------- 48
           A  EY+ SD+ LD  + VE   +   G++ S   S+  T++S +                
Sbjct: 67  AKVEYAYSDNSLDPGLFVE---STRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYK 123

Query: 49  -----ARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVD 103
                 R+R     E++RRD I     +L+ +VP+  ++Q    GS KL KA +LQ T+D
Sbjct: 124 ESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTC-QQQDFSIGSQKLSKAIVLQKTID 182

Query: 104 HLKMLHTAGGKGYFDAHALAMDYRSL 129
           +++ LH    K   +   L  D  +L
Sbjct: 183 YIQFLHKEKKKQEEEVSTLRKDVTAL 208


>gi|38201612 transcription factor-like protein 4 isoform beta [Homo
           sapiens]
          Length = 244

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 40/143 (27%), Positives = 66/143 (46%), Gaps = 24/143 (16%)

Query: 7   EYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQIL------------------ 48
           EY+ SD+ LD  + VE   +   G++ S   S+  T++S +                   
Sbjct: 16  EYAYSDNSLDPGLFVE---STRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESY 72

Query: 49  --ARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLK 106
              R+R     E++RRD I     +L+ +VP+  ++Q    GS KL KA +LQ T+D+++
Sbjct: 73  KDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTC-QQQDFSIGSQKLSKAIVLQKTIDYIQ 131

Query: 107 MLHTAGGKGYFDAHALAMDYRSL 129
            LH    K   +   L  D  +L
Sbjct: 132 FLHKEKKKQEEEVSTLRKDVTAL 154


>gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]
          Length = 412

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 22/129 (17%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKG 115
           +IEK+RRDRIN  +++L+ L+P   +   +      LEKA +L++T+ H+K L     + 
Sbjct: 59  LIEKKRRDRINECIAQLKDLLPEHLKLTTL----GHLEKAVVLELTLKHVKALTNLIDQQ 114

Query: 116 YFDAHALAMDYRS----------------LGFRECLAEVARYLSIIEGLDASDPLRVRLV 159
                AL    ++                 GF+ C  EV +YL+  E  +  D    +LV
Sbjct: 115 QQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLV 172

Query: 160 SHLNNYASQ 168
           +HL+   S+
Sbjct: 173 THLHRVVSE 181


>gi|38201614 transcription factor-like protein 4 isoform alpha [Homo
           sapiens]
          Length = 214

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 1/80 (1%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           R+R     E++RRD I     +L+ +VP+  ++Q    GS KL KA +LQ T+D+++ LH
Sbjct: 46  RRRAHTQAEQKRRDAIKRGYDDLQTIVPTC-QQQDFSIGSQKLSKAIVLQKTIDYIQFLH 104

Query: 110 TAGGKGYFDAHALAMDYRSL 129
               K   +   L  D  +L
Sbjct: 105 KEKKKQEEEVSTLRKDVTAL 124


>gi|66912172 hairy and enhancer of split 3 [Homo sapiens]
          Length = 186

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 48/165 (29%), Positives = 79/165 (47%), Gaps = 15/165 (9%)

Query: 57  IEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGY 116
           +EK+RR RIN SL +L+ L+   +  Q+ ++   KLEKA+IL+++V +++ L  +  +G 
Sbjct: 1   MEKKRRARINVSLEQLKSLLEKHYSHQIRKR---KLEKADILELSVKYMRSLQNS-LQGL 56

Query: 117 FDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAH 176
           +     A   +  GFR CL  V++ L    G +    LR  LV      ++   A  G  
Sbjct: 57  WPVPRGA--EQPSGFRSCLPGVSQLLR--RGDEVGSGLRCPLVPESAAGSTMDSAGLGQE 112

Query: 177 AGLGHIP-WGTVFGHHPHIAHP------LLLPQNGHGNAGTTASP 214
           A     P    V+   P    P      LLLP++  G++ +   P
Sbjct: 113 APALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPP 157


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 14/101 (13%)

Query: 11  SDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLS 70
           S ++  E+++ +K+  D +G L             +I   +     IEKRRRD++N+ + 
Sbjct: 42  SSTDYQESMDTDKD--DPHGRLEYT------EHQGRIKNAREAHSQIEKRRRDKMNSFID 93

Query: 71  ELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTA 111
           EL  LVP+          S KL+K  +L+M V H+K L  A
Sbjct: 94  ELASLVPTC------NAMSRKLDKLTVLRMAVQHMKTLRGA 128


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 14/101 (13%)

Query: 11  SDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLS 70
           S ++  E+++ +K+  D +G L             +I   +     IEKRRRD++N+ + 
Sbjct: 42  SSTDYQESMDTDKD--DPHGRLEYT------EHQGRIKNAREAHSQIEKRRRDKMNSFID 93

Query: 71  ELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTA 111
           EL  LVP+          S KL+K  +L+M V H+K L  A
Sbjct: 94  ELASLVPTC------NAMSRKLDKLTVLRMAVQHMKTLRGA 128


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 24/55 (43%), Positives = 33/55 (60%), Gaps = 6/55 (10%)

Query: 57  IEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTA 111
           IEKRRRD++N+ + EL  LVP+          S KL+K  +L+M V H+K L  A
Sbjct: 37  IEKRRRDKMNSFIDELASLVPTC------NAMSRKLDKLTVLRMAVQHMKTLRGA 85


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 6/51 (11%)

Query: 58  EKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKML 108
           EKRRRD++NN + EL  ++P           + KL+K  +L+M V HL+ L
Sbjct: 116 EKRRRDKMNNLIEELSAMIPQC------NPMARKLDKLTVLRMAVQHLRSL 160


>gi|66529407 tensin [Homo sapiens]
          Length = 1735

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 43/133 (32%), Positives = 51/133 (38%), Gaps = 15/133 (11%)

Query: 173  SGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNA-GTTASPTEPHHQGRLGSAHPEAP 231
            SG H  +   P     G HP  AH   L    H NA  +  SP+   H G  GS  P +P
Sbjct: 1257 SGLHNKVATTPGSPSLGRHPG-AHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSP 1315

Query: 232  AL-RAPPSGSLG------PVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALS 284
             L R    G         P L   +SAS    P      S  +FP S   +  LS  A S
Sbjct: 1316 CLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAP------STPSFPVSPAYYPGLSSPATS 1369

Query: 285  PSAPTQAANLGKP 297
            PS  + A   G P
Sbjct: 1370 PSPDSAAFRQGSP 1382


>gi|52630419 sterol regulatory element binding transcription factor
           1 isoform a [Homo sapiens]
          Length = 1177

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 9/80 (11%)

Query: 35  ALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEK 94
           A GS +P ++     ++     IEKR R  IN+ + EL+ LV             AKL K
Sbjct: 339 AAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGT---------EAKLNK 389

Query: 95  AEILQMTVDHLKMLHTAGGK 114
           + +L+  +D+++ L  +  K
Sbjct: 390 SAVLRKAIDYIRFLQHSNQK 409


>gi|22547195 sterol regulatory element binding transcription factor
           1 isoform b [Homo sapiens]
          Length = 1147

 Score = 38.5 bits (88), Expect = 0.008
 Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 9/80 (11%)

Query: 35  ALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEK 94
           A GS +P ++     ++     IEKR R  IN+ + EL+ LV             AKL K
Sbjct: 309 AAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGT---------EAKLNK 359

Query: 95  AEILQMTVDHLKMLHTAGGK 114
           + +L+  +D+++ L  +  K
Sbjct: 360 SAVLRKAIDYIRFLQHSNQK 379


>gi|24307933 transcription factor EB [Homo sapiens]
          Length = 476

 Score = 36.6 bits (83), Expect = 0.029
 Identities = 22/68 (32%), Positives = 40/68 (58%), Gaps = 10/68 (14%)

Query: 45  SQILARKRRR----GIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQM 100
           S+ LA++R++     +IE+RRR  IN+ + EL  L+P A +  V      +  K  IL+ 
Sbjct: 227 SRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDV------RWNKGTILKA 280

Query: 101 TVDHLKML 108
           +VD+++ +
Sbjct: 281 SVDYIRRM 288


>gi|8659574 transcription factor E3 [Homo sapiens]
          Length = 575

 Score = 36.2 bits (82), Expect = 0.038
 Identities = 24/99 (24%), Positives = 43/99 (43%), Gaps = 6/99 (6%)

Query: 10  SSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSL 69
           SS       I V      E  N+   +         +   +K    +IE+RRR  IN+ +
Sbjct: 307 SSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRI 366

Query: 70  SELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKML 108
            EL  L+P + + ++      +  K  IL+ +VD+++ L
Sbjct: 367 KELGTLIPKSSDPEM------RWNKGTILKASVDYIRKL 399


>gi|27477113 sterol regulatory element-binding transcription factor
           2 [Homo sapiens]
          Length = 1141

 Score = 35.8 bits (81), Expect = 0.049
 Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 9/65 (13%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
           R+    IIEKR R  IN+ + EL+ LV             AK+ K+ +L+  +D++K L 
Sbjct: 331 RRTTHNIIEKRYRSSINDKIIELKDLVMGT---------DAKMHKSGVLRKAIDYIKYLQ 381

Query: 110 TAGGK 114
               K
Sbjct: 382 QVNHK 386


>gi|4557755 microphthalmia-associated transcription factor isoform 4
           [Homo sapiens]
          Length = 419

 Score = 35.4 bits (80), Expect = 0.064
 Identities = 23/73 (31%), Positives = 43/73 (58%), Gaps = 11/73 (15%)

Query: 41  PTTS-SQILARKRRR----GIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKA 95
           PT S ++ LA++R++     +IE+RRR  IN+ + EL  L+P + +  +      +  K 
Sbjct: 191 PTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDM------RWNKG 244

Query: 96  EILQMTVDHLKML 108
            IL+ +VD+++ L
Sbjct: 245 TILKASVDYIRKL 257


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,270,048
Number of Sequences: 37866
Number of extensions: 585171
Number of successful extensions: 3036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 2778
Number of HSP's gapped (non-prelim): 360
length of query: 308
length of database: 18,247,518
effective HSP length: 102
effective length of query: 206
effective length of database: 14,385,186
effective search space: 2963348316
effective search space used: 2963348316
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.