Guide to the Human Genome
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Search of human proteins with 102470001

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
         (472 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   991   0.0  
gi|32189425 WD repeat domain 69 [Homo sapiens]                        145   6e-35
gi|16554629 WD repeat domain 5 [Homo sapiens]                         124   2e-28
gi|16554627 WD repeat domain 5 [Homo sapiens]                         124   2e-28
gi|113865883 WD repeat domain 38 [Homo sapiens]                       122   7e-28
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   120   3e-27
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   120   3e-27
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   120   3e-27
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   119   8e-27
gi|23199987 WD repeat domain 5B [Homo sapiens]                        119   8e-27
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            112   9e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   101   1e-21
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...   100   5e-21
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...   100   5e-21
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...   100   5e-21
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...   100   5e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       98   2e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     96   5e-20
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    94   2e-19
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    94   2e-19
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    94   2e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             92   8e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             92   8e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    92   1e-18
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    92   1e-18
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     91   2e-18
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     91   2e-18
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     91   2e-18
gi|26665869 WD repeat domain 51B [Homo sapiens]                        91   2e-18
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    90   4e-18

>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score =  991 bits (2563), Expect = 0.0
 Identities = 472/472 (100%), Positives = 472/472 (100%)

Query: 1   MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP 60
           MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP
Sbjct: 1   MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP 60

Query: 61  LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG 120
           LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG
Sbjct: 61  LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG 120

Query: 121 SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL 180
           SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL
Sbjct: 121 SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL 180

Query: 181 WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP 240
           WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP
Sbjct: 181 WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP 240

Query: 241 DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW 300
           DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW
Sbjct: 241 DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW 300

Query: 301 NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360
           NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK
Sbjct: 301 NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360

Query: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR 420
           GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR
Sbjct: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR 420

Query: 421 PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD 472
           PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD
Sbjct: 421 PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD 472


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  145 bits (367), Expect = 6e-35
 Identities = 88/305 (28%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 88  DPLSKIPFKILSGHEHAVSTCHFCVD-DTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
           D  S      L GH + V    F      K+ +GS+D T KLW    G     F     A
Sbjct: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT-A 178

Query: 147 PVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGF 205
            +V  S    S+ V   S D T + WD++ G+ ++ +R +   I+S  F+  G  +++G 
Sbjct: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG- 237

Query: 206 DVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
             DH + + DA+    V+++  H    I+S  F+ D   + + S+D+  K+WD T+   +
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGH-CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296

Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVS 325
            T+T  H + I + CF ++G  + T+S D   +I++  T +      C+  ++GHEG +S
Sbjct: 297 ATLT-GHDDEILDSCFDYTGKLIATASADGTARIFSAATRK------CIAKLEGHEGEIS 349

Query: 326 SCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDR 385
              F    + L++G  D+T  IWD   G     L+GH D +   A +     +++ SKD 
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409

Query: 386 TMRLW 390
           T R+W
Sbjct: 410 TCRIW 414



 Score =  114 bits (285), Expect = 2e-25
 Identities = 74/300 (24%), Positives = 125/300 (41%), Gaps = 10/300 (3%)

Query: 95  FKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
           FK+L  H   ++        +  ++GSYD T KLWD   G  +   E             
Sbjct: 85  FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICI 213
               ++   S+DKT + W +ETGK     R  T  + C  F+P    V +G  +D    +
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG-SMDTTAKL 203

Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
            D +N   V  ++ H +  I S  F+    R+ + S D  + +WD  +    + I   H 
Sbjct: 204 WDIQNGEEVYTLRGH-SAEIISLSFNTSGDRIITGSFDHTVVVWDADT-GRKVNILIGHC 261

Query: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
             IS+  F +    + T S DK  K+W+   G+      CV  + GH+  +    F    
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGK------CVATLTGHDDEILDSCFDYTG 315

Query: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
             + +   D T  I+  A       L+GH   +  ++ +     +L+ S D+T R+W+ +
Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 44/175 (25%), Positives = 83/175 (47%), Gaps = 8/175 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFS-GHF 287
           H   +T+   +       + S DR  K+WD  S   L T+ + H N +    F    G  
Sbjct: 91  HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL-EGHRNVVYAIAFNNPYGDK 149

Query: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347
           + T S+DK  K+W+V TG+      C    +GH   +    F   S+ + +G  D T  +
Sbjct: 150 IATGSFDKTCKLWSVETGK------CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 348 WDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
           WD+  G    +L+GH+  ++ ++ + +   I++ S D T+ +W+ +   ++ ++I
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 35/135 (25%), Positives = 64/135 (47%), Gaps = 7/135 (5%)

Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
           L  + KAH   ++N     SG    T S+D+  K+W+  +GE  N       ++GH   V
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELN------TLEGHRNVV 137

Query: 325 SSCHFARD-SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
            +  F       + +G FD+T  +W V  G    + +GH   ++ ++ +     + + S 
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197

Query: 384 DRTMRLWNIEEIDEI 398
           D T +LW+I+  +E+
Sbjct: 198 DTTAKLWDIQNGEEV 212


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  124 bits (310), Expect = 2e-28
 Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L+GH  AVS+  F  +   L S S D  +K+W   DG   +      K  + + + + DS
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
           + +++AS DKT++ WD+ +GK L  ++ +  ++  C F+P    +VSG   D  + I D 
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           +    +  +  H +  +++  F+ D   + S S D   +IWD  S   L T+    +  +
Sbjct: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
           S   F+ +G ++  ++ D  LK+W+   G+      C+    GH+     C FA  S   
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270

Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
             +++SG  D  V IW++        L+GH D V+  A    +  I SA+   D+T++LW
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  111 bits (278), Expect = 1e-24
 Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)

Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
           + S KFSP+G+++ S    D  I I  A +      I  H    I+   +  DS  + S 
Sbjct: 48  VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105

Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
           S D+ +KIWDV+S   L T+ K HSN +  C F    + + + S+D++++IW+V TG+  
Sbjct: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162

Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
               C+  +  H   VS+ HF RD S ++S  +D    IWD A G   K  +   N  V 
Sbjct: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218

Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
            V  S N K+IL+A+ D T++LW+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242



 Score =  100 bits (249), Expect = 3e-21
 Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           HT++++S  F P+ + +AS S D+ IKIW         TI+  H   IS+  ++   + L
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            ++S DK LKIW+V +G+      C+  ++GH   V  C+F   S+ ++SG FD +V IW
Sbjct: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           DV  G    +L  H+D V  V  + +   I+S+S D   R+W+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 24/275 (8%)

Query: 83  IWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH 142
           IWG  D   +   K +SGH+  +S   +  D   L+S S D T+K+WD   G  ++  + 
Sbjct: 71  IWGAYDGKFE---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127

Query: 143 RPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYV 201
                V  C+    S+ +++ S+D++VR WD++TGK L  +   +  VS   F+ DG  +
Sbjct: 128 HSNY-VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186

Query: 202 V-SGFDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV 259
           V S +D   G+C I D  +   +  + D     ++   F P+ + + + +LD  +K+WD 
Sbjct: 187 VSSSYD---GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 260 TSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVT 315
           +    L T T  H N    C F  FS   G ++ + S D  + IWN+ T E       V 
Sbjct: 244 SKGKCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQ 295

Query: 316 LMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
            +QGH   V  ++CH   +     +   D+T+ +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)

Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
           H+ A+S+  F+ +G +L +SS DK +KIW  + G+F         + GH+  +S   ++ 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97

Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           DS+ L+S   D+T+ IWDV+ G    +LKGH+++V     +     I+S S D ++R+W+
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 392 IE 393
           ++
Sbjct: 158 VK 159



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
           + GH  +VSS  F+ +  +L S   D+ + IW   +G  + ++ GH   + DVA S++  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 377 WILSASKDRTMRLWNI 392
            ++SAS D+T+++W++
Sbjct: 101 LLVSASDDKTLKIWDV 116



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
           K +L GH   V  V  S N +W+ S+S D+ +++W
Sbjct: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  124 bits (310), Expect = 2e-28
 Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L+GH  AVS+  F  +   L S S D  +K+W   DG   +      K  + + + + DS
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
           + +++AS DKT++ WD+ +GK L  ++ +  ++  C F+P    +VSG   D  + I D 
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           +    +  +  H +  +++  F+ D   + S S D   +IWD  S   L T+    +  +
Sbjct: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
           S   F+ +G ++  ++ D  LK+W+   G+      C+    GH+     C FA  S   
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270

Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
             +++SG  D  V IW++        L+GH D V+  A    +  I SA+   D+T++LW
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  111 bits (278), Expect = 1e-24
 Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)

Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
           + S KFSP+G+++ S    D  I I  A +      I  H    I+   +  DS  + S 
Sbjct: 48  VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105

Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
           S D+ +KIWDV+S   L T+ K HSN +  C F    + + + S+D++++IW+V TG+  
Sbjct: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162

Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
               C+  +  H   VS+ HF RD S ++S  +D    IWD A G   K  +   N  V 
Sbjct: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218

Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
            V  S N K+IL+A+ D T++LW+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242



 Score =  100 bits (249), Expect = 3e-21
 Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           HT++++S  F P+ + +AS S D+ IKIW         TI+  H   IS+  ++   + L
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            ++S DK LKIW+V +G+      C+  ++GH   V  C+F   S+ ++SG FD +V IW
Sbjct: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           DV  G    +L  H+D V  V  + +   I+S+S D   R+W+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 24/275 (8%)

Query: 83  IWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH 142
           IWG  D   +   K +SGH+  +S   +  D   L+S S D T+K+WD   G  ++  + 
Sbjct: 71  IWGAYDGKFE---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127

Query: 143 RPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYV 201
                V  C+    S+ +++ S+D++VR WD++TGK L  +   +  VS   F+ DG  +
Sbjct: 128 HSNY-VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186

Query: 202 V-SGFDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV 259
           V S +D   G+C I D  +   +  + D     ++   F P+ + + + +LD  +K+WD 
Sbjct: 187 VSSSYD---GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 260 TSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVT 315
           +    L T T  H N    C F  FS   G ++ + S D  + IWN+ T E       V 
Sbjct: 244 SKGKCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQ 295

Query: 316 LMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
            +QGH   V  ++CH   +     +   D+T+ +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)

Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
           H+ A+S+  F+ +G +L +SS DK +KIW  + G+F         + GH+  +S   ++ 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97

Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           DS+ L+S   D+T+ IWDV+ G    +LKGH+++V     +     I+S S D ++R+W+
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 392 IE 393
           ++
Sbjct: 158 VK 159



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
           + GH  +VSS  F+ +  +L S   D+ + IW   +G  + ++ GH   + DVA S++  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 377 WILSASKDRTMRLWNI 392
            ++SAS D+T+++W++
Sbjct: 101 LLVSASDDKTLKIWDV 116



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
           K +L GH   V  V  S N +W+ S+S D+ +++W
Sbjct: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  122 bits (306), Expect = 7e-28
 Identities = 73/238 (30%), Positives = 121/238 (50%), Gaps = 10/238 (4%)

Query: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIM 214
           D   ++  S D  V  W+  +G+LLW++   T  V  C+FSPDG    S    D  + + 
Sbjct: 32  DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA-SCDCTVRLW 90

Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
           D      + V+K H  RS+ +  F PDS+++AS   D+ + +WDV S   +L +   H +
Sbjct: 91  DVARAKCLRVLKGHQ-RSVETVSFSPDSRQLASGGWDKRVMLWDVQS-GQMLRLLVGHRD 148

Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSS-CHFARDS 333
           +I +  F+ + + L T SWD  + IW++              ++GH  ++S  C+ A  S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLR---MVTPAVSHQALEGHSANISCLCYSA--S 203

Query: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
             L SG +D+T+ IW        + LKGH  WV  +A S ++ W+ SA   R +++W+
Sbjct: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261



 Score =  110 bits (274), Expect = 4e-24
 Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 13/296 (4%)

Query: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
           K    H   V++  F  D   LL+GS D  V  W+   G ++         PV  C  + 
Sbjct: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT-GPVKFCRFSP 73

Query: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
           D     +AS D TVR WD+   K L  ++ +   + +  FSPD + + SG   D  + + 
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG-GWDKRVMLW 132

Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV--TSQATLLTITKAH 272
           D ++   + ++  H   SI S  F P    +A+ S D  + IWD+   + A      + H
Sbjct: 133 DVQSGQMLRLLVGHRD-SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191

Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARD 332
           S  IS  C++ SG  L + SWDK + IW   T         +  ++GH   V S  F+ D
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL------LIQLKGHVTWVKSIAFSPD 244

Query: 333 SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
             +L S G+ R V +WD   G    +LKG  D     A + + K ++S + D+T R
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 7/167 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           H   + S  F PD Q + + S D C+  W+ T    LL     H+  +  C F+  GH  
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            ++S D  +++W+V   +      C+ +++GH+ SV +  F+ DS  L SGG+D+ V +W
Sbjct: 79  ASASCDCTVRLWDVARAK------CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 395
           DV  G     L GH D +     S     + + S D T+ +W++  +
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 6/137 (4%)

Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
           H   +++  F+  G  L T S D  +  W   +G+       +  + GH G V  C F+ 
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL------LWRLGGHTGPVKFCRFSP 73

Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           D     S   D TV +WDVA       LKGH   V  V+ S + + + S   D+ + LW+
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 392 IEEIDEIPLVIKYKKAV 408
           ++    + L++ ++ ++
Sbjct: 134 VQSGQMLRLLVGHRDSI 150


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  120 bits (301), Expect = 3e-27
 Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)

Query: 96  KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
           K+L GH+  V TC  FC    +++SGS D T+K+W  V G  +R          V  S  
Sbjct: 256 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 311

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
            D+  +I+ S D+T++ W+ ETG+ +  +   T  V C    + K VVSG   D  + + 
Sbjct: 312 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 368

Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
           D E    + V+  H        C   D +RV S + D  +K+WD  ++  L T+ + H+N
Sbjct: 369 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 424

Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
            + +    F G  + + S D ++++W+V TG       C+  + GH+   S        +
Sbjct: 425 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 474

Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
            L+SG  D TV IWD+  G    +L+G N     V  +  NK +++++S D T++LW+++
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 534



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L GH   V   H  + + +++SGS D T+++WD   G  +        A  V C +  D 
Sbjct: 339 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 393

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
            RV++ +YD  V+ WD ET   L  ++  T  + S +F  DG +VVSG  +D  I + D 
Sbjct: 394 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 450

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           E    +  +  H  +S+TS     D+  V+  + D  +KIWD+ +   L T+   + +  
Sbjct: 451 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 507

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
           +  C  F+ +F+ TSS D  +K+W++ TGEF RN    VTL  G  G V
Sbjct: 508 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 553


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  120 bits (301), Expect = 3e-27
 Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)

Query: 96  KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
           K+L GH+  V TC  FC    +++SGS D T+K+W  V G  +R          V  S  
Sbjct: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 429

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
            D+  +I+ S D+T++ W+ ETG+ +  +   T  V C    + K VVSG   D  + + 
Sbjct: 430 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 486

Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
           D E    + V+  H        C   D +RV S + D  +K+WD  ++  L T+ + H+N
Sbjct: 487 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 542

Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
            + +    F G  + + S D ++++W+V TG       C+  + GH+   S        +
Sbjct: 543 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 592

Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
            L+SG  D TV IWD+  G    +L+G N     V  +  NK +++++S D T++LW+++
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L GH   V   H  + + +++SGS D T+++WD   G  +        A  V C +  D 
Sbjct: 457 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 511

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
            RV++ +YD  V+ WD ET   L  ++  T  + S +F  DG +VVSG  +D  I + D 
Sbjct: 512 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 568

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           E    +  +  H  +S+TS     D+  V+  + D  +KIWD+ +   L T+   + +  
Sbjct: 569 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 625

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
           +  C  F+ +F+ TSS D  +K+W++ TGEF RN    VTL  G  G V
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 671


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  120 bits (301), Expect = 3e-27
 Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)

Query: 96  KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
           K+L GH+  V TC  FC    +++SGS D T+K+W  V G  +R          V  S  
Sbjct: 294 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 349

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
            D+  +I+ S D+T++ W+ ETG+ +  +   T  V C    + K VVSG   D  + + 
Sbjct: 350 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 406

Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
           D E    + V+  H        C   D +RV S + D  +K+WD  ++  L T+ + H+N
Sbjct: 407 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 462

Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
            + +    F G  + + S D ++++W+V TG       C+  + GH+   S        +
Sbjct: 463 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 512

Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
            L+SG  D TV IWD+  G    +L+G N     V  +  NK +++++S D T++LW+++
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 572



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L GH   V   H  + + +++SGS D T+++WD   G  +        A  V C +  D 
Sbjct: 377 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 431

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
            RV++ +YD  V+ WD ET   L  ++  T  + S +F  DG +VVSG  +D  I + D 
Sbjct: 432 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 488

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           E    +  +  H  +S+TS     D+  V+  + D  +KIWD+ +   L T+   + +  
Sbjct: 489 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 545

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
           +  C  F+ +F+ TSS D  +K+W++ TGEF RN    VTL  G  G V
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 591


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  119 bits (297), Expect = 8e-27
 Identities = 78/305 (25%), Positives = 144/305 (47%), Gaps = 10/305 (3%)

Query: 94  PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
           P  +LSGHE  V  C F  + + L S  +D  + LW+                 V+E   
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117

Query: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGIC 212
             D S + +AS DKTV  WD ETG+ + +++ + +F+ SC  +  G  +V     D  + 
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177

Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
           + D      +   ++  T  + +  F+  S ++ S  +D  IK+WD+       T+ + H
Sbjct: 178 LWDIRKKAAIQTFQN--TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-RGH 234

Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH----EGSVSSCH 328
           +++++    +  G +L +++ D  +++W+V    F     CV + QG+    E ++  C 
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP--FAPKERCVKIFQGNVHNFEKNLLRCS 292

Query: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
           ++ D S + +G  DR V +WD         L GH   + +VA   ++  I+SAS D+ + 
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352

Query: 389 LWNIE 393
           +  I+
Sbjct: 353 MGEIQ 357



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 31/83 (37%), Positives = 49/83 (59%), Gaps = 1/83 (1%)

Query: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV-AEGYRKLSLKGHNDWVMDVA 370
           A + L+ GHEG V  C F  + S L S GFDR + +W+V  +     +LKGH+  VM++ 
Sbjct: 57  APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116

Query: 371 ISNNKKWILSASKDRTMRLWNIE 393
            + +   + SAS D+T+ +W+ E
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSE 139


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  119 bits (297), Expect = 8e-27
 Identities = 81/300 (27%), Positives = 143/300 (47%), Gaps = 17/300 (5%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L GH  AVS+  F  +   L S S D  + +W   DG   +   +     + + + + DS
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDS 95

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
           SR+++AS DKT++ WD+ +GK L  ++ +  ++  C F+P    ++SG   D  + I + 
Sbjct: 96  SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG-SFDETVKIWEV 154

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
           +    +  +  H +  +++  F+     + S S D   +IWD  S   L T+    +  +
Sbjct: 155 KTGKCLKTLSAH-SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
           S   F+ +G ++ T++ D  LK+W+   G       C+    GH+     C FA  S   
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGR------CLKTYTGHKNE-KYCIFANFSVTG 266

Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
             +++SG  D  V IW++        L+GH D V+  A    +  I SA+   D+T++LW
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score =  110 bits (274), Expect = 4e-24
 Identities = 69/204 (33%), Positives = 105/204 (51%), Gaps = 10/204 (4%)

Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
           + S KFSP+G+++ S    D  I I  A +      +  H+   I+   +  DS R+ S 
Sbjct: 44  VSSVKFSPNGEWLASS-SADRLIIIWGAYDGKYEKTLYGHNLE-ISDVAWSSDSSRLVSA 101

Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
           S D+ +K+WDV S   L T+ K HSN +  C F    + + + S+D+ +KIW V TG+  
Sbjct: 102 SDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK-- 158

Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
               C+  +  H   VS+ HF    S ++SG +D    IWD A G   K  +   N  V 
Sbjct: 159 ----CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214

Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
            V  S N K+IL+A+ D T++LW+
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWD 238



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 24/276 (8%)

Query: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
           +IWG  D   +   K L GH   +S   +  D ++L+S S D T+KLWD   G  ++  +
Sbjct: 66  IIWGAYDGKYE---KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK 122

Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKY 200
                 V  C+    S+ +I+ S+D+TV+ W+++TGK L  +   +  VS   F+  G  
Sbjct: 123 GHSNY-VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181

Query: 201 VVSG-FDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 258
           +VSG +D   G+C I DA +   +  + D     ++   F P+ + + + +LD  +K+WD
Sbjct: 182 IVSGSYD---GLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238

Query: 259 VTSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACV 314
            +    L T T  H N    C F  FS   G ++ + S D  + IWN+ T E       V
Sbjct: 239 YSRGRCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------V 290

Query: 315 TLMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
             +QGH   V  ++CH   +     +   D+T+ +W
Sbjct: 291 QKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 55/163 (33%), Positives = 86/163 (52%), Gaps = 7/163 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           HT +++S  F P+ + +AS S DR I IW         T+   H+  IS+  ++     L
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSRL 98

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            ++S DK LK+W+V +G+      C+  ++GH   V  C+F   S+ +ISG FD TV IW
Sbjct: 99  VSASDDKTLKLWDVRSGK------CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           +V  G    +L  H+D V  V  + +   I+S S D   R+W+
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 43/155 (27%), Positives = 82/155 (52%), Gaps = 7/155 (4%)

Query: 239 DPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLK 298
           D  +Q   S S ++  ++ +  + A   T+   H+ A+S+  F+ +G +L +SS D+ + 
Sbjct: 8   DAKAQLALSSSANQSKEVPENPNYALKCTLV-GHTEAVSSVKFSPNGEWLASSSADRLII 66

Query: 299 IWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLS 358
           IW  + G++         + GH   +S   ++ DSS L+S   D+T+ +WDV  G    +
Sbjct: 67  IWGAYDGKYEKT------LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120

Query: 359 LKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
           LKGH+++V     +     I+S S D T+++W ++
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  112 bits (279), Expect = 9e-25
 Identities = 80/252 (31%), Positives = 119/252 (47%), Gaps = 13/252 (5%)

Query: 99  SGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDP-VDGSVVRDFEHRPKAPVVECSITGDS 157
           +GH+ AV+  +F      L SGS D TV++W P V G       H   A V       D 
Sbjct: 20  TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH--TATVRSVHFCSDG 77

Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICIMDA 216
              + AS DKTV+ W     K L+ +      V C KFSPDG+ +VS  D D  + + D 
Sbjct: 78  QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-DKTVKLWDK 136

Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
            +   V    + H   +T   F P    +A+  +D  +K+WDV +   LL   + HS A+
Sbjct: 137 SSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAV 194

Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFL 336
           +   F  SG++L T+S D  LKI ++  G        +  + GH+G  ++  F+R   + 
Sbjct: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRL------LYTLHGHQGPATTVAFSRTGEYF 248

Query: 337 ISGGFDRTVAIW 348
            SGG D  V +W
Sbjct: 249 ASGGSDEQVMVW 260



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)

Query: 250 LDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRN 309
           +D C+ +W +  Q+     T  H +A++   F+ SGH L + S DK ++IW        N
Sbjct: 1   MDSCLMVWHMKPQSRAYRFT-GHKDAVTCVNFSPSGHLLASGSRDKTVRIW------VPN 53

Query: 310 CGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV 369
                T+ + H  +V S HF  D    ++   D+TV +W         SL  H +WV   
Sbjct: 54  VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 113

Query: 370 AISNNKKWILSASKDRTMRLWN 391
             S + + I+SAS D+T++LW+
Sbjct: 114 KFSPDGRLIVSASDDKTVKLWD 135


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  101 bits (252), Expect = 1e-21
 Identities = 72/268 (26%), Positives = 123/268 (45%), Gaps = 30/268 (11%)

Query: 145 KAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVS 203
           ++PV         S +++AS D T++ WD ETG     ++  T  V    F   GK + S
Sbjct: 108 RSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLAS 167

Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
               D  I + D +    +  +  H   +++S    P+   + S S D+ IK+W+V +  
Sbjct: 168 -CSADMTIKLWDFQGFECIRTMHGHD-HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225

Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
            + T T  H   +        G  + + S D+ +++W V T E      C   ++ HE  
Sbjct: 226 CVKTFT-GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE------CKAELREHEHV 278

Query: 324 VSSCHFARDSS--------------------FLISGGFDRTVAIWDVAEGYRKLSLKGHN 363
           V    +A +SS                    FL+SG  D+T+ +WDV+ G   ++L GH+
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338

Query: 364 DWVMDVAISNNKKWILSASKDRTMRLWN 391
           +WV  V   +  K+ILS + D+T+R+W+
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWD 366



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 7/162 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           H   +T   F P    + S S D  IK+WD  +     T+ K H++++ +  F  SG  L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL-KGHTDSVQDISFDHSGKLL 165

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            + S D  +K+W+    E      C+  M GH+ +VSS     +   ++S   D+T+ +W
Sbjct: 166 ASCSADMTIKLWDFQGFE------CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
           +V  GY   +  GH +WV  V  + +   I S S D+T+R+W
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 63/256 (24%), Positives = 120/256 (46%), Gaps = 35/256 (13%)

Query: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE-HRPKAPVVECSIT 154
           + + GH+H VS+     +   ++S S D T+K+W+   G  V+ F  HR    +V  +  
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN-- 243

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICI 213
            D + + + S D+TVR W + T +   ++R    +V C  ++P+  Y             
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSY------------- 290

Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
                 +++S      T+             + S S D+ IK+WDV++   L+T+   H 
Sbjct: 291 ------SSISEATGSETKK-----SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV-GHD 338

Query: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
           N +    F   G F+ + + DK L++W     +++N   C+  +  HE  V+S  F + +
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVW-----DYKN-KRCMKTLNAHEHFVTSLDFHKTA 392

Query: 334 SFLISGGFDRTVAIWD 349
            ++++G  D+TV +W+
Sbjct: 393 PYVVTGSVDQTVKVWE 408



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 73/319 (22%), Positives = 135/319 (42%), Gaps = 41/319 (12%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA---PVVECSIT 154
           LSGH   V+   F    + ++S S D T+K+WD   G    DFE   K     V + S  
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG----DFERTLKGHTDSVQDISFD 159

Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICI 213
                + + S D T++ WD +  + +  +  +D  + S    P+G ++VS    D  I +
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA-SRDKTIKM 218

Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
            + +    V     H    +     + D   +AS S D+ +++W V ++     + + H 
Sbjct: 219 WEVQTGYCVKTFTGHR-EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL-REHE 276

Query: 274 NAISNCCFTFS----------------------GHFLCTSSWDKNLKIWNVHTGEFRNCG 311
           + +   C +++                      G FL + S DK +K+W+V TG      
Sbjct: 277 HVVE--CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG------ 328

Query: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAI 371
            C+  + GH+  V    F     F++S   D+T+ +WD        +L  H  +V  +  
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDF 388

Query: 372 SNNKKWILSASKDRTMRLW 390
                ++++ S D+T+++W
Sbjct: 389 HKTAPYVVTGSVDQTVKVW 407



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 35/123 (28%), Positives = 63/123 (51%), Gaps = 8/123 (6%)

Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
           H + ++   F      + ++S D  +K+W+  TG+F         ++GH  SV    F  
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT------LKGHTDSVQDISFDH 160

Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKL-SLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
               L S   D T+ +WD  +G+  + ++ GH+  V  VAI  N   I+SAS+D+T+++W
Sbjct: 161 SGKLLASCSADMTIKLWDF-QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219

Query: 391 NIE 393
            ++
Sbjct: 220 EVQ 222



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 25/77 (32%), Positives = 42/77 (54%)

Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
           + GH   V+   F    S ++S   D T+ +WD   G  + +LKGH D V D++  ++ K
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 377 WILSASKDRTMRLWNIE 393
            + S S D T++LW+ +
Sbjct: 164 LLASCSADMTIKLWDFQ 180



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 16/43 (37%), Positives = 25/43 (58%)

Query: 88  DPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWD 130
           D  +K   K L+ HEH V++  F      +++GS D TVK+W+
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646

Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699

Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759

Query: 380 SASKDRTMRLWNIEEIDE 397
           S S D T++LW+    +E
Sbjct: 760 SCSADGTLKLWDATSANE 777



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 77/343 (22%), Positives = 144/343 (41%), Gaps = 60/343 (17%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
            GH ++V+ C F  DD  L S S D T+KLWD    +             + D +   +  
Sbjct: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800

Query: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
            V  CS + D +R++ A+ +K +  W+ ++   +   R + +++    FSPDG   ++  D
Sbjct: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859

Query: 207  VDHGICIMDAENITTVSVIK-------------------DHHTR---------------- 231
             D  I + + + +   S +                    DH  R                
Sbjct: 860  -DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 918

Query: 232  -SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
              ++ CC  P  Q +A    +  I+I ++ +     +  + H   + +  FT     L +
Sbjct: 919  AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLIS 977

Query: 291  SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
            SS D  +++WN    +      C+ L +GH+ +V      ++S  L+S  FD TV +W++
Sbjct: 978  SSDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNI 1029

Query: 351  AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
              G ++     H   V+   IS++     S S D+T ++W+ +
Sbjct: 1030 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1072



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)

Query: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654

Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713

Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773

Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307
           S     +I            +     I  CC ++  G  +  ++ +K + +WN  +  + 
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 832

Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
            +C       +GH   V    F+ D S  ++   D+T+ +W+  +  +  ++    +  +
Sbjct: 833 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 883

Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
           DV    N+  +L+    R ++L N
Sbjct: 884 DVVFQENEVMVLAVDHIRRLQLIN 907



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 997  LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1054

Query: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1113

Query: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 1114 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1163



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 893

Query: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 894  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 949

Query: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 950  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1007

Query: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 1008 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1066

Query: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 1067 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1126

Query: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 1127 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1161



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 13/45 (28%), Positives = 23/45 (51%)

Query: 93   IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
            +P   L GH   V    F VD T L +G  +  +++W+  +G ++
Sbjct: 1075 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1119


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646

Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699

Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759

Query: 380 SASKDRTMRLWNIEEIDE 397
           S S D T++LW+    +E
Sbjct: 760 SCSADGTLKLWDATSANE 777



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)

Query: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654

Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713

Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773

Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
           S     +I            +     I  CC ++  G  +  ++ +K + ++++HT    
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 829

Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368
             G    +  GH  ++  C F+  +   +       V +W+     +    +GH  WV  
Sbjct: 830 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 887

Query: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395
           V  S +    L++S D+T+RLW  +++
Sbjct: 888 VMFSPDGSSFLTSSDDQTIRLWETKKV 914



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 81/386 (20%), Positives = 145/386 (37%), Gaps = 103/386 (26%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
            GH ++V+ C F  DD  L S S D T+KLWD    +             + D +   +  
Sbjct: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800

Query: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLL--------------------------- 180
            V  CS + D +R++ A+ +K +  +D+ T  LL                           
Sbjct: 801  VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859

Query: 181  -------WKVRYDTFIVSCK----------FSPDGKYVVSGFDVDHGICIMDAENITTVS 223
                   W     + +  C+          FSPDG   ++  D D  I + + + +   S
Sbjct: 860  SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKNS 918

Query: 224  VIK-------------------DHHTR-----------------SITSCCFDPDSQRVAS 247
             +                    DH  R                  ++ CC  P  Q +A 
Sbjct: 919  AVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAF 978

Query: 248  VSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF 307
               +  I+I ++ +     +  + H   + +  FT     L +SS D  +++WN    + 
Sbjct: 979  GDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK- 1036

Query: 308  RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
                 C+ L +GH+ +V      ++S  L+S  FD TV +W++  G ++     H   V+
Sbjct: 1037 -----CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL 1089

Query: 368  DVAISNNKKWILSASKDRTMRLWNIE 393
               IS++     S S D+T ++W+ +
Sbjct: 1090 SCDISHDATKFSSTSADKTAKIWSFD 1115



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 1040 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1097

Query: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 1098 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1156

Query: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 1157 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1206



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 880  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 936

Query: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 937  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 992

Query: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 993  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1050

Query: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 1051 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109

Query: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 1110 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1169

Query: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 1170 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1204



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 13/45 (28%), Positives = 23/45 (51%)

Query: 93   IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
            +P   L GH   V    F VD T L +G  +  +++W+  +G ++
Sbjct: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635

Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688

Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748

Query: 380 SASKDRTMRLWNIEEIDE 397
           S S D T++LW+    +E
Sbjct: 749 SCSADGTLKLWDATSANE 766



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 77/343 (22%), Positives = 144/343 (41%), Gaps = 60/343 (17%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
            GH ++V+ C F  DD  L S S D T+KLWD    +             + D +   +  
Sbjct: 730  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789

Query: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
            V  CS + D +R++ A+ +K +  W+ ++   +   R + +++    FSPDG   ++  D
Sbjct: 790  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848

Query: 207  VDHGICIMDAENITTVSVIK-------------------DHHTR---------------- 231
             D  I + + + +   S +                    DH  R                
Sbjct: 849  -DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 907

Query: 232  -SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
              ++ CC  P  Q +A    +  I+I ++ +     +  + H   + +  FT     L +
Sbjct: 908  AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLIS 966

Query: 291  SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
            SS D  +++WN    +      C+ L +GH+ +V      ++S  L+S  FD TV +W++
Sbjct: 967  SSDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNI 1018

Query: 351  AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
              G ++     H   V+   IS++     S S D+T ++W+ +
Sbjct: 1019 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1061



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)

Query: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643

Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702

Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762

Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307
           S     +I            +     I  CC ++  G  +  ++ +K + +WN  +  + 
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 821

Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
            +C       +GH   V    F+ D S  ++   D+T+ +W+  +  +  ++    +  +
Sbjct: 822 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 872

Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
           DV    N+  +L+    R ++L N
Sbjct: 873 DVVFQENEVMVLAVDHIRRLQLIN 896



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 986  LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1043

Query: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1102

Query: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 1103 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1152



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 826  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 882

Query: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 883  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 938

Query: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 939  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 996

Query: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 997  RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1055

Query: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 1056 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1115

Query: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 1116 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1150



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 13/45 (28%), Positives = 23/45 (51%)

Query: 93   IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
            +P   L GH   V    F VD T L +G  +  +++W+  +G ++
Sbjct: 1064 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1108


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635

Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688

Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748

Query: 380 SASKDRTMRLWNIEEIDE 397
           S S D T++LW+    +E
Sbjct: 749 SCSADGTLKLWDATSANE 766



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)

Query: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643

Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702

Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762

Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
           S     +I            +     I  CC ++  G  +  ++ +K + ++++HT    
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 818

Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368
             G    +  GH  ++  C F+  +   +       V +W+     +    +GH  WV  
Sbjct: 819 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 876

Query: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395
           V  S +    L++S D+T+RLW  +++
Sbjct: 877 VMFSPDGSSFLTSSDDQTIRLWETKKV 903



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 81/386 (20%), Positives = 145/386 (37%), Gaps = 103/386 (26%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
            GH ++V+ C F  DD  L S S D T+KLWD    +             + D +   +  
Sbjct: 730  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789

Query: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLL--------------------------- 180
            V  CS + D +R++ A+ +K +  +D+ T  LL                           
Sbjct: 790  VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848

Query: 181  -------WKVRYDTFIVSCK----------FSPDGKYVVSGFDVDHGICIMDAENITTVS 223
                   W     + +  C+          FSPDG   ++  D D  I + + + +   S
Sbjct: 849  SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKNS 907

Query: 224  VIK-------------------DHHTR-----------------SITSCCFDPDSQRVAS 247
             +                    DH  R                  ++ CC  P  Q +A 
Sbjct: 908  AVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAF 967

Query: 248  VSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF 307
               +  I+I ++ +     +  + H   + +  FT     L +SS D  +++WN    + 
Sbjct: 968  GDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK- 1025

Query: 308  RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
                 C+ L +GH+ +V      ++S  L+S  FD TV +W++  G ++     H   V+
Sbjct: 1026 -----CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL 1078

Query: 368  DVAISNNKKWILSASKDRTMRLWNIE 393
               IS++     S S D+T ++W+ +
Sbjct: 1079 SCDISHDATKFSSTSADKTAKIWSFD 1104



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 1029 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1086

Query: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1145

Query: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 1146 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1195



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 925

Query: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 926  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 981

Query: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 982  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1039

Query: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 1040 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098

Query: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158

Query: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1193



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 13/45 (28%), Positives = 23/45 (51%)

Query: 93   IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
            +P   L GH   V    F VD T L +G  +  +++W+  +G ++
Sbjct: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 55/173 (31%), Positives = 88/173 (50%), Gaps = 9/173 (5%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           HT  ++ CCF P   ++A+ S D  +K+WD+     +LT  + HS A+ +C +   G+F+
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTF-EGHSRAVWSCTWHSCGNFV 451

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            +SS DK  KIW+V      N   C   + GH  SV+S  F   S+ L++   D+T++IW
Sbjct: 452 ASSSLDKTSKIWDV------NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLV 401
           D   G  + SL GH   + D         I S       +LW+  ++  +P+V
Sbjct: 506 DARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKL--LPIV 556



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 72/251 (28%), Positives = 107/251 (42%), Gaps = 14/251 (5%)

Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
           GH   +S C F     KL + S D TVKLWD   G  +  FE   +A V  C+     + 
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRA-VWSCTWHSCGNF 450

Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGFDVDHGICIMDAE- 217
           V ++S DKT + WD+ + +    +   T  V S +F P    +++    D  + I DA  
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTS-SADKTLSIWDART 509

Query: 218 NITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAIS 277
            I   S+    H  SI    FDP    +AS       K+WD      +++I    S   +
Sbjct: 510 GICEQSLY--GHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPG-N 566

Query: 278 NCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLI 337
              F  SG  L  +S +  + + ++ +GE          + GHE    +  F+ D   L 
Sbjct: 567 EVNFDSSGRVLAQASGNGVIHLLDLKSGEIHK-------LMGHENEAHTVVFSHDGEILF 619

Query: 338 SGGFDRTVAIW 348
           SGG D TV  W
Sbjct: 620 SGGSDGTVRTW 630



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 7/163 (4%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           H   ++     P    + S   DR  K+  +     LLT    H++ +S+CCF  SG  L
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLT-GFGHTDWLSDCCFHPSGDKL 409

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
            TSS D  +K+W++  G+      C+   +GH  +V SC +    +F+ S   D+T  IW
Sbjct: 410 ATSSGDTTVKLWDLCKGD------CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW 463

Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           DV     + +L GH D V  +        +L++S D+T+ +W+
Sbjct: 464 DVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 62/266 (23%), Positives = 98/266 (36%), Gaps = 74/266 (27%)

Query: 179 LLWKVRYDTFIVSCKFSPDGKYVVSG--------FDVDHGICIMDAENITTVSVIKDHHT 230
           LL    +  ++  C F P G  + +         +D+  G CI+  E           H+
Sbjct: 387 LLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEG----------HS 436

Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
           R++ SC +      VAS SLD+  KIWDV S+    T+   H++++++  F    + L T
Sbjct: 437 RAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLY-GHTDSVNSIEFFPFSNTLLT 495

Query: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
           SS DK L IW+  TG       C   + GH  S++   F      + S        +WD 
Sbjct: 496 SSADKTLSIWDARTG------ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD- 548

Query: 351 AEGYRKL---------------------------------------------SLKGHNDW 365
              +RKL                                              L GH + 
Sbjct: 549 ---FRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENE 605

Query: 366 VMDVAISNNKKWILSASKDRTMRLWN 391
              V  S++ + + S   D T+R W+
Sbjct: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 21/74 (28%), Positives = 38/74 (51%)

Query: 319 GHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWI 378
           GH   +S C F      L +   D TV +WD+ +G   L+ +GH+  V      +   ++
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451

Query: 379 LSASKDRTMRLWNI 392
            S+S D+T ++W++
Sbjct: 452 ASSSLDKTSKIWDV 465



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 24/89 (26%), Positives = 41/89 (46%)

Query: 320 HEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
           HE  VS          L+S G DR   +  + +    L+  GH DW+ D     +   + 
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410

Query: 380 SASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
           ++S D T++LW++ + D I     + +AV
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAV 439


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 76/282 (26%), Positives = 124/282 (43%), Gaps = 25/282 (8%)

Query: 113 DDTKLLSGSY-DCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRA 171
           DD+ L++G + D TV++W  V    +R  +              D S +   S D   R 
Sbjct: 480 DDSSLIAGGFADSTVRVWS-VTPKKLRSVKQ-----------ASDLSLIDKESDDVLERI 527

Query: 172 WDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHH 229
            D +T   L K+ Y     +    FSPD  Y++S  + D  + +   +  T +   K H+
Sbjct: 528 MDEKTASEL-KILYGHSGPVYGASFSPDRNYLLSSSE-DGTVRLWSLQTFTCLVGYKGHN 585

Query: 230 TRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLC 289
              +    F P      S   DR  ++W  T     L I   H   ++   F  + +++ 
Sbjct: 586 Y-PVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 290 TSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWD 349
           T S D+ +++W+V  G       CV +  GH+G + S  F+ +  FL +G  D  V +WD
Sbjct: 644 TGSADRTVRLWDVLNGN------CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697

Query: 350 VAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           +  G     LKGH D V  +  S + + + S S D T+RLW+
Sbjct: 698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 63/212 (29%), Positives = 101/212 (47%), Gaps = 10/212 (4%)

Query: 147 PVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGF 205
           PV   S + D + ++++S D TVR W L+T   L   +   + V   +FSP G Y VSG 
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604

Query: 206 DVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
             D    +   ++   + +   H    +    F P+S  VA+ S DR +++WDV +    
Sbjct: 605 H-DRVARLWATDHYQPLRIFAGH-LADVNCTRFHPNSNYVATGSADRTVRLWDVLN-GNC 661

Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVS 325
           + I   H   I +  F+ +G FL T + D  + +W++        G  V  ++GH  +V 
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI------GHGLMVGELKGHTDTVC 715

Query: 326 SCHFARDSSFLISGGFDRTVAIWDVAEGYRKL 357
           S  F+RD   L SG  D TV +WD  + +  L
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 59/241 (24%), Positives = 104/241 (43%), Gaps = 21/241 (8%)

Query: 153 ITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGIC 212
           +T DSS +     D TVR W +   KL           S K + D   +    D D    
Sbjct: 478 VTDDSSLIAGGFADSTVRVWSVTPKKLR----------SVKQASDLSLIDKESD-DVLER 526

Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
           IMD +  + + ++  H +  +    F PD   + S S D  +++W + +  T L   K H
Sbjct: 527 IMDEKTASELKILYGH-SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-FTCLVGYKGH 584

Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNV-HTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
           +  + +  F+  G++  +   D+  ++W   H    R       +  GH   V+   F  
Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-------IFAGHLADVNCTRFHP 637

Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
           +S+++ +G  DRTV +WDV  G       GH   +  +  S N +++ + + D  + LW+
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697

Query: 392 I 392
           I
Sbjct: 698 I 698



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 56/229 (24%), Positives = 102/229 (44%), Gaps = 9/229 (3%)

Query: 74  EKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVD 133
           E   V E+++  D+   S++  KIL GH   V    F  D   LLS S D TV+LW    
Sbjct: 519 ESDDVLERIM--DEKTASEL--KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT 574

Query: 134 GSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC- 192
            + +  ++     PV +   +      ++  +D+  R W  +  + L         V+C 
Sbjct: 575 FTCLVGYKGH-NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633

Query: 193 KFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDR 252
           +F P+  YV +G   D  + + D  N   V +    H   I S  F P+ + +A+ + D 
Sbjct: 634 RFHPNSNYVATG-SADRTVRLWDVLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDG 691

Query: 253 CIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWN 301
            + +WD+     ++   K H++ + +  F+  G  L + S D  +++W+
Sbjct: 692 RVLLWDI-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 3/124 (2%)

Query: 94  PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
           P +I +GH   V+   F  +   + +GS D TV+LWD ++G+ VR F    K P+   + 
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH-KGPIHSLTF 677

Query: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDT-FIVSCKFSPDGKYVVSGFDVDHGIC 212
           + +   +   + D  V  WD+  G ++ +++  T  + S +FS DG+ + SG  +D+ + 
Sbjct: 678 SPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG-SMDNTVR 736

Query: 213 IMDA 216
           + DA
Sbjct: 737 LWDA 740



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 36/96 (37%)

Query: 332 DSSFLISGGF-DRTVAIWDVAEGYRKLS-------------------------------- 358
           D S LI+GGF D TV +W V    +KL                                 
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTP--KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELK 537

Query: 359 -LKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
            L GH+  V   + S ++ ++LS+S+D T+RLW+++
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 16/35 (45%), Positives = 19/35 (54%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPV 132
           L GH   V +  F  D   L SGS D TV+LWD +
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           DD K++SG  D ++K+WD      ++       +  V C +  D   ++  S D TVR W
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 305

Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D+ TG++L   + ++  ++  +FS +G  V      D  I + D  + T +++ +     
Sbjct: 306 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 362

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
                  D D + + S S DR IK+W  TS    +     H   I+  C  +    + + 
Sbjct: 363 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 419

Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
           S D  +++W++       CGAC+ +++GHE  V    F  D+  ++SG +D  + +WD+ 
Sbjct: 420 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 471

Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
                   A      +L  H+  V  +     +  I+S+S D T+ +W+
Sbjct: 472 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 518



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)

Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
           C   D +++ S   D  IKIWD TS   L  +T  H+ ++   C  +    + T S D  
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 301

Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
           +++W+V+TGE  N     TL+  +E  +   H    +  +++   DR++A+WD+A     
Sbjct: 302 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 353

Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
             +  L GH   V    +  + K+I+SAS DRT+++W+    + +  +  +K+ +
Sbjct: 354 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 406


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           DD K++SG  D ++K+WD      ++       +  V C +  D   ++  S D TVR W
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 271

Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D+ TG++L   + ++  ++  +FS +G  V      D  I + D  + T +++ +     
Sbjct: 272 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 328

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
                  D D + + S S DR IK+W  TS    +     H   I+  C  +    + + 
Sbjct: 329 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 385

Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
           S D  +++W++       CGAC+ +++GHE  V    F  D+  ++SG +D  + +WD+ 
Sbjct: 386 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 437

Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
                   A      +L  H+  V  +     +  I+S+S D T+ +W+
Sbjct: 438 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 484



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)

Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
           C   D +++ S   D  IKIWD TS   L  +T  H+ ++   C  +    + T S D  
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 267

Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
           +++W+V+TGE  N     TL+  +E  +   H    +  +++   DR++A+WD+A     
Sbjct: 268 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 319

Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
             +  L GH   V    +  + K+I+SAS DRT+++W+    + +  +  +K+ +
Sbjct: 320 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 372


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           DD K++SG  D ++K+WD      ++       +  V C +  D   ++  S D TVR W
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 292

Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D+ TG++L   + ++  ++  +FS +G  V      D  I + D  + T +++ +     
Sbjct: 293 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 349

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
                  D D + + S S DR IK+W  TS    +     H   I+  C  +    + + 
Sbjct: 350 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 406

Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
           S D  +++W++       CGAC+ +++GHE  V    F  D+  ++SG +D  + +WD+ 
Sbjct: 407 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 458

Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
                   A      +L  H+  V  +     +  I+S+S D T+ +W+
Sbjct: 459 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 505



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)

Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
           C   D +++ S   D  IKIWD TS   L  +T  H+ ++   C  +    + T S D  
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 288

Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
           +++W+V+TGE  N     TL+  +E  +   H    +  +++   DR++A+WD+A     
Sbjct: 289 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 340

Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
             +  L GH   V    +  + K+I+SAS DRT+++W+    + +  +  +K+ +
Sbjct: 341 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 393


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 79/315 (25%), Positives = 137/315 (43%), Gaps = 20/315 (6%)

Query: 87  QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
           +DP  +  FK   GH  AV+   F ++  +L SGS D  + +W     S  R +      
Sbjct: 7   EDPSLERHFK---GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHK 61

Query: 147 PVVECSITGDSSRVIAA-SYDKTVRAW--DLETGKLLWKVRYDTFIVSCKFSPDGKYVVS 203
             V C     S  ++A+ S DKTVR W  +++    +++    T + S  F  DG+  V+
Sbjct: 62  DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-VRSVHFCSDGQSFVT 120

Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
             D D  + +        +  +  H    +    F PD + + S S D+ +K+WD +S+ 
Sbjct: 121 ASD-DKTVKVWATHRQKFLFSLSQH-INWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178

Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
            + +  + H   ++   F  SG  +  +  D  +K+W+V T         +   Q H  +
Sbjct: 179 CVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL------LQHYQLHSAA 231

Query: 324 VSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
           V+   F    ++LI+   D T+ I D+ EG    +L GH      VA S   ++  S   
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291

Query: 384 DRTMRLW--NIEEID 396
           D  + +W  N + +D
Sbjct: 292 DEQVMVWKSNFDIVD 306


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 79/315 (25%), Positives = 137/315 (43%), Gaps = 20/315 (6%)

Query: 87  QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
           +DP  +  FK   GH  AV+   F ++  +L SGS D  + +W     S  R +      
Sbjct: 7   EDPSLERHFK---GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHK 61

Query: 147 PVVECSITGDSSRVIAA-SYDKTVRAW--DLETGKLLWKVRYDTFIVSCKFSPDGKYVVS 203
             V C     S  ++A+ S DKTVR W  +++    +++    T + S  F  DG+  V+
Sbjct: 62  DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-VRSVHFCSDGQSFVT 120

Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
             D D  + +        +  +  H    +    F PD + + S S D+ +K+WD +S+ 
Sbjct: 121 ASD-DKTVKVWATHRQKFLFSLSQH-INWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178

Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
            + +  + H   ++   F  SG  +  +  D  +K+W+V T         +   Q H  +
Sbjct: 179 CVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL------LQHYQLHSAA 231

Query: 324 VSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
           V+   F    ++LI+   D T+ I D+ EG    +L GH      VA S   ++  S   
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291

Query: 384 DRTMRLW--NIEEID 396
           D  + +W  N + +D
Sbjct: 292 DEQVMVWKSNFDIVD 306


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 73/289 (25%), Positives = 130/289 (44%), Gaps = 29/289 (10%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           DD K++SG  D T+K+WD       R       +  V C +  D   +I  S D TVR W
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS--VLC-LQYDERVIITGSSDSTVRVW 332

Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D+ TG++L   + +   ++  +F+ +G  V      D  I + D  + T +++ +     
Sbjct: 333 DVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTC--SKDRSIAVWDMASPTDITLRRVLVGH 389

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
                  D D + + S S DR IK+W+ TS    +     H   I+  C  +    + + 
Sbjct: 390 RAAVNVVDFDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 446

Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351
           S D  +++W++       CGAC+ +++GHE  V    F  D+  ++SG +D  + +WD+ 
Sbjct: 447 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLV 498

Query: 352 EGYRKLSLKG---------HNDWVMDVAISNNKKWILSASKDRTMRLWN 391
                 +  G         H+  V  +     +  I+S+S D T+ +W+
Sbjct: 499 AALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 545



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 19/186 (10%)

Query: 229 HTRSITS---CCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSG 285
           H RS TS    C   D Q++ S   D  IKIWD  +      +T  H+ ++   C  +  
Sbjct: 261 HCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDE 317

Query: 286 HFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTV 345
             + T S D  +++W+V+TGE  N     TL+   E  +   H   ++  +++   DR++
Sbjct: 318 RVIITGSSDSTVRVWDVNTGEMLN-----TLIHHCEAVL---HLRFNNGMMVTCSKDRSI 369

Query: 346 AIWDVAEGYR---KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
           A+WD+A       +  L GH   V  V   +  K+I+SAS DRT+++WN    + +  + 
Sbjct: 370 AVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNTSTCEFVRTLN 427

Query: 403 KYKKAV 408
            +K+ +
Sbjct: 428 GHKRGI 433



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 60/244 (24%), Positives = 113/244 (46%), Gaps = 32/244 (13%)

Query: 163 ASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSP---------DGKYVVSGFDVDHGIC 212
           A Y K ++  D+ET +  W+  R+    + C+            D + +VSG   D+ I 
Sbjct: 234 ALYPKIIQ--DIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLR-DNTIK 290

Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
           I D   +    ++  H T S+   C   D + + + S D  +++WDV +   L T+   H
Sbjct: 291 IWDKNTLECKRILTGH-TGSVL--CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-H 346

Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQ---GHEGSVSSCHF 329
             A+ +    F+   + T S D+++ +W++ +         +TL +   GH  +V+   F
Sbjct: 347 CEAVLH--LRFNNGMMVTCSKDRSIAVWDMASP------TDITLRRVLVGHRAAVNVVDF 398

Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
             D  +++S   DRT+ +W+ +      +L GH   +    +    + ++S S D T+RL
Sbjct: 399 --DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRL 454

Query: 390 WNIE 393
           W+IE
Sbjct: 455 WDIE 458


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 73/289 (25%), Positives = 130/289 (44%), Gaps = 29/289 (10%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           DD K++SG  D T+K+WD       R       +  V C +  D   +I  S D TVR W
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS--VLC-LQYDERVIITGSSDSTVRVW 368

Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D+ TG++L   + +   ++  +F+ +G  V      D  I + D  + T +++ +     
Sbjct: 369 DVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTC--SKDRSIAVWDMASPTDITLRRVLVGH 425

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
                  D D + + S S DR IK+W+ TS    +     H   I+  C  +    + + 
Sbjct: 426 RAAVNVVDFDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 482

Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351
           S D  +++W++       CGAC+ +++GHE  V    F  D+  ++SG +D  + +WD+ 
Sbjct: 483 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLV 534

Query: 352 EGYRKLSLKG---------HNDWVMDVAISNNKKWILSASKDRTMRLWN 391
                 +  G         H+  V  +     +  I+S+S D T+ +W+
Sbjct: 535 AALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 581



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 19/186 (10%)

Query: 229 HTRSITS---CCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSG 285
           H RS TS    C   D Q++ S   D  IKIWD  +      +T  H+ ++   C  +  
Sbjct: 297 HCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDE 353

Query: 286 HFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTV 345
             + T S D  +++W+V+TGE  N     TL+   E  +   H   ++  +++   DR++
Sbjct: 354 RVIITGSSDSTVRVWDVNTGEMLN-----TLIHHCEAVL---HLRFNNGMMVTCSKDRSI 405

Query: 346 AIWDVAEGYR---KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
           A+WD+A       +  L GH   V  V   +  K+I+SAS DRT+++WN    + +  + 
Sbjct: 406 AVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNTSTCEFVRTLN 463

Query: 403 KYKKAV 408
            +K+ +
Sbjct: 464 GHKRGI 469



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 60/244 (24%), Positives = 113/244 (46%), Gaps = 32/244 (13%)

Query: 163 ASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSP---------DGKYVVSGFDVDHGIC 212
           A Y K ++  D+ET +  W+  R+    + C+            D + +VSG   D+ I 
Sbjct: 270 ALYPKIIQ--DIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLR-DNTIK 326

Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
           I D   +    ++  H T S+   C   D + + + S D  +++WDV +   L T+   H
Sbjct: 327 IWDKNTLECKRILTGH-TGSVL--CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-H 382

Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQ---GHEGSVSSCHF 329
             A+ +    F+   + T S D+++ +W++ +         +TL +   GH  +V+   F
Sbjct: 383 CEAVLH--LRFNNGMMVTCSKDRSIAVWDMASP------TDITLRRVLVGHRAAVNVVDF 434

Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
             D  +++S   DRT+ +W+ +      +L GH   +    +    + ++S S D T+RL
Sbjct: 435 --DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRL 490

Query: 390 WNIE 393
           W+IE
Sbjct: 491 WDIE 494


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)

Query: 56  ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
           AT+ P A+ ++ PP              H +   H  P ++    + P +K    +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178

Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
           E  V  C +      L SGS D T ++W+  + S            +R+  H   +   V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
                  D + +   SYD   R W  E G L   + ++   I + K++  G YV+S   V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296

Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
           D    I DA           H   ++     D D Q     AS S D CI +  +     
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
           + T  + H+N ++   +  SG  L + S D  LKIW++         ACV  +Q H   +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404

Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
            +  ++           S  L S  FD TV +WDV +G    +L  H + V  VA S + 
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464

Query: 376 KWILSASKDRTMRLWNIE 393
           K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           D T L  GSYD   ++W           +H  K P+         + V++A  DKT   W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303

Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D  TG+   +  + +   +   +  +  +     D+   +C +  ++          HT 
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
            + +  +DP    +AS S D  +KIW +   A +  + +AHS  I    ++ +G      
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419

Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
                L ++S+D  +++W+V  G       C   +  H+  V S  F+ D  +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 343 RTVAIWDVAEGYRKLSLKG 361
           + V IW+   G    S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)

Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
           + +TS  ++ D   +A  S D   +IW  T    L +    H   I    +   G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
           +  DK   IW+ HTGE +                                    C   V 
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353

Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
             QGH   V++  +      L S   D T+ IW + +      L+ H+  +  +  S   
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413

Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
                 N+   + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441



 Score = 32.3 bits (72), Expect = 0.96
 Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L  H+  V +  F  D   L SGS+D  V +W+   GS+V  ++      + E       
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505

Query: 158 SRVIAASYDKTVRAWDL 174
            +V A++ D +V   DL
Sbjct: 506 DKVGASASDGSVCVLDL 522


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)

Query: 56  ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
           AT+ P A+ ++ PP              H +   H  P ++    + P +K    +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178

Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
           E  V  C +      L SGS D T ++W+  + S            +R+  H   +   V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
                  D + +   SYD   R W  E G L   + ++   I + K++  G YV+S   V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296

Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
           D    I DA           H   ++     D D Q     AS S D CI +  +     
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
           + T  + H+N ++   +  SG  L + S D  LKIW++         ACV  +Q H   +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404

Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
            +  ++           S  L S  FD TV +WDV +G    +L  H + V  VA S + 
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464

Query: 376 KWILSASKDRTMRLWNIE 393
           K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           D T L  GSYD   ++W           +H  K P+         + V++A  DKT   W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303

Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D  TG+   +  + +   +   +  +  +     D+   +C +  ++          HT 
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
            + +  +DP    +AS S D  +KIW +   A +  + +AHS  I    ++ +G      
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419

Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
                L ++S+D  +++W+V  G       C   +  H+  V S  F+ D  +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 343 RTVAIWDVAEGYRKLSLKG 361
           + V IW+   G    S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)

Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
           + +TS  ++ D   +A  S D   +IW  T    L +    H   I    +   G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
           +  DK   IW+ HTGE +                                    C   V 
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353

Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
             QGH   V++  +      L S   D T+ IW + +      L+ H+  +  +  S   
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413

Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
                 N+   + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441



 Score = 32.3 bits (72), Expect = 0.96
 Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L  H+  V +  F  D   L SGS+D  V +W+   GS+V  ++      + E       
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505

Query: 158 SRVIAASYDKTVRAWDL 174
            +V A++ D +V   DL
Sbjct: 506 DKVGASASDGSVCVLDL 522


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)

Query: 56  ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
           AT+ P A+ ++ PP              H +   H  P ++    + P +K    +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178

Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
           E  V  C +      L SGS D T ++W+  + S            +R+  H   +   V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
                  D + +   SYD   R W  E G L   + ++   I + K++  G YV+S   V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296

Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
           D    I DA           H   ++     D D Q     AS S D CI +  +     
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
           + T  + H+N ++   +  SG  L + S D  LKIW++         ACV  +Q H   +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404

Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
            +  ++           S  L S  FD TV +WDV +G    +L  H + V  VA S + 
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464

Query: 376 KWILSASKDRTMRLWNIE 393
           K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)

Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
           D T L  GSYD   ++W           +H  K P+         + V++A  DKT   W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303

Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
           D  TG+   +  + +   +   +  +  +     D+   +C +  ++          HT 
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360

Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
            + +  +DP    +AS S D  +KIW +   A +  + +AHS  I    ++ +G      
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419

Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
                L ++S+D  +++W+V  G       C   +  H+  V S  F+ D  +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473

Query: 343 RTVAIWDVAEGYRKLSLKG 361
           + V IW+   G    S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)

Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
           + +TS  ++ D   +A  S D   +IW  T    L +    H   I    +   G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
           +  DK   IW+ HTGE +                                    C   V 
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353

Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
             QGH   V++  +      L S   D T+ IW + +      L+ H+  +  +  S   
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413

Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
                 N+   + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441



 Score = 32.3 bits (72), Expect = 0.96
 Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
           L  H+  V +  F  D   L SGS+D  V +W+   GS+V  ++      + E       
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505

Query: 158 SRVIAASYDKTVRAWDL 174
            +V A++ D +V   DL
Sbjct: 506 DKVGASASDGSVCVLDL 522


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 80/313 (25%), Positives = 142/313 (45%), Gaps = 18/313 (5%)

Query: 87  QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWD-PVDGSVVRDFEHRPK 145
           +DP+ +  FK   GH+ A+++     +  +L + S+D  + LW+        R   H+  
Sbjct: 6   EDPVLERYFK---GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62

Query: 146 APVVECSITGDSSRVIAASYDKTVRAWDLET-GKLLWKVRYDTFIVSCKFSPDGKYVVSG 204
              V+ S  G+   + +AS D+TVR W  +  GK      +   + S  FS DG+++ + 
Sbjct: 63  VTSVQFSPHGNL--LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120

Query: 205 FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQAT 264
            + D  I +        +  +   HT  +    F PD + + S S D+ IKIWD T++  
Sbjct: 121 SE-DKSIKVWSMYRQRFLYSLY-RHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178

Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
           +   + +   A +   F  SG  + ++  D+ +K+W+V   +       +   Q H G V
Sbjct: 179 VNNFSDSVGFA-NFVDFNPSGTCIASAGSDQTVKVWDVRVNKL------LQHYQVHSGGV 231

Query: 325 SSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKD 384
           +   F    ++LI+   D T+ I D+ EG    +L+GH   V  V+ S   +   S   D
Sbjct: 232 NCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291

Query: 385 RTMRLW--NIEEI 395
             + LW  N +E+
Sbjct: 292 TQVLLWRTNFDEL 304



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 10/135 (7%)

Query: 260 TSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNV--HTGEFRNCGACVTLM 317
           T    L    K H  AI++   + +G  L T+SWD  L +WN   H   +R  G      
Sbjct: 5   TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG------ 58

Query: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
             H+  V+S  F+   + L S   DRTV +W   +  +    K H   V  V  S + ++
Sbjct: 59  --HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116

Query: 378 ILSASKDRTMRLWNI 392
           + +AS+D+++++W++
Sbjct: 117 LATASEDKSIKVWSM 131


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 66/244 (27%), Positives = 115/244 (47%), Gaps = 22/244 (9%)

Query: 160 VIAASYDKTVRAWDLETGKLLWKVR------YDTFIVSCKFSPDGKYVVSGFDVDHGICI 213
           +++AS DKT+  W L   +  + +       +  F+     S DG++ +SG   D  + +
Sbjct: 31  ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSG-SWDGTLRL 89

Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
            D    TT      H T+ + S  F  D++++ S S D+ IK+W+           ++HS
Sbjct: 90  WDLTTGTTTRRFVGH-TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148

Query: 274 NAISNCCFTFSGH----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHF 329
             +S  C  FS +     + +  WDK +K+WN+      NC    T   GH G +++   
Sbjct: 149 EWVS--CVRFSPNSSNPIIVSCGWDKLVKVWNL-----ANC-KLKTNHIGHTGYLNTVTV 200

Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
           + D S   SGG D    +WD+ EG    +L G  D +  +  S N+ W L A+   ++++
Sbjct: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYW-LCAATGPSIKI 258

Query: 390 WNIE 393
           W++E
Sbjct: 259 WDLE 262



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 21/274 (7%)

Query: 93  IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECS 152
           IP + L GH H VS      D    LSGS+D T++LWD   G+  R F    K  V+  +
Sbjct: 54  IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVA 112

Query: 153 ITGDSSRVIAASYDKTVRAWD-LETGKLLWKVRYDTFIVSC-KFSPDGK---YVVSGFDV 207
            + D+ ++++ S DKT++ W+ L   K   +    +  VSC +FSP+      V  G+D 
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172

Query: 208 DHGICIMDAENITTVSVIKDH--HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
                ++   N+    +  +H  HT  + +    PD    AS   D    +WD+     L
Sbjct: 173 -----LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227

Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVH----TGEFRNCGACVTLMQGHE 321
            T+     + I+  CF+ + ++LC ++   ++KIW++       E +      T  +   
Sbjct: 228 YTLD--GGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQ-EVISTSSKAEP 283

Query: 322 GSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYR 355
              +S  ++ D   L +G  D  V +W V  G R
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 41/134 (30%), Positives = 69/134 (51%), Gaps = 2/134 (1%)

Query: 259 VTSQATLLTITKAHSNAISNCCFTFS-GHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLM 317
           +T Q TL    K H+  ++    T      + ++S DK + +W + T +  N G     +
Sbjct: 1   MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-TRDETNYGIPQRAL 59

Query: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
           +GH   VS    + D  F +SG +D T+ +WD+  G       GH   V+ VA S++ + 
Sbjct: 60  RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119

Query: 378 ILSASKDRTMRLWN 391
           I+S S+D+T++LWN
Sbjct: 120 IVSGSRDKTIKLWN 133



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 12/170 (7%)

Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
           H+  ++      D Q   S S D  +++WD+T+  T       H+  + +  F+     +
Sbjct: 62  HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQI 120

Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQ--GHEGSVSSCHFARDSS--FLISGGFDRT 344
            + S DK +K+WN         G C   +Q   H   VS   F+ +SS   ++S G+D+ 
Sbjct: 121 VSGSRDKTIKLWNT-------LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173

Query: 345 VAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEE 394
           V +W++A    K +  GH  ++  V +S +     S  KD    LW++ E
Sbjct: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 6/82 (7%)

Query: 317 MQGHEGSVSSCHFARD-SSFLISGGFDRTVAIWDVAE-----GYRKLSLKGHNDWVMDVA 370
           ++GH G V+           ++S   D+T+ +W +       G  + +L+GH+ +V DV 
Sbjct: 11  LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70

Query: 371 ISNNKKWILSASKDRTMRLWNI 392
           IS++ ++ LS S D T+RLW++
Sbjct: 71  ISSDGQFALSGSWDGTLRLWDL 92


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,701,954
Number of Sequences: 37866
Number of extensions: 940496
Number of successful extensions: 7098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 3504
Number of HSP's gapped (non-prelim): 1572
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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