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Search of human proteins with 102470001
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 991 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 145 6e-35
gi|16554629 WD repeat domain 5 [Homo sapiens] 124 2e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 124 2e-28
gi|113865883 WD repeat domain 38 [Homo sapiens] 122 7e-28
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 120 3e-27
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 120 3e-27
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 120 3e-27
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 119 8e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 119 8e-27
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 112 9e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 101 1e-21
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 100 5e-21
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 100 5e-21
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 100 5e-21
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 100 5e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 98 2e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens] 96 5e-20
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 94 2e-19
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 94 2e-19
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 94 2e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 92 8e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 92 8e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 92 1e-18
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 92 1e-18
gi|19913367 transducin beta-like 1Y [Homo sapiens] 91 2e-18
gi|19913365 transducin beta-like 1Y [Homo sapiens] 91 2e-18
gi|15150805 transducin beta-like 1Y [Homo sapiens] 91 2e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 91 2e-18
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 90 4e-18
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 991 bits (2563), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP 60
MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP
Sbjct: 1 MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP 60
Query: 61 LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG 120
LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG
Sbjct: 61 LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG 120
Query: 121 SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL 180
SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL
Sbjct: 121 SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL 180
Query: 181 WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP 240
WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP
Sbjct: 181 WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP 240
Query: 241 DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW 300
DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW
Sbjct: 241 DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW 300
Query: 301 NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360
NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK
Sbjct: 301 NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360
Query: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR 420
GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR
Sbjct: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR 420
Query: 421 PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD 472
PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD
Sbjct: 421 PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD 472
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 145 bits (367), Expect = 6e-35
Identities = 88/305 (28%), Positives = 148/305 (48%), Gaps = 12/305 (3%)
Query: 88 DPLSKIPFKILSGHEHAVSTCHFCVD-DTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
D S L GH + V F K+ +GS+D T KLW G F A
Sbjct: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT-A 178
Query: 147 PVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGF 205
+V S S+ V S D T + WD++ G+ ++ +R + I+S F+ G +++G
Sbjct: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG- 237
Query: 206 DVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
DH + + DA+ V+++ H I+S F+ D + + S+D+ K+WD T+ +
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGH-CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVS 325
T+T H + I + CF ++G + T+S D +I++ T + C+ ++GHEG +S
Sbjct: 297 ATLT-GHDDEILDSCFDYTGKLIATASADGTARIFSAATRK------CIAKLEGHEGEIS 349
Query: 326 SCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDR 385
F + L++G D+T IWD G L+GH D + A + +++ SKD
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409
Query: 386 TMRLW 390
T R+W
Sbjct: 410 TCRIW 414
Score = 114 bits (285), Expect = 2e-25
Identities = 74/300 (24%), Positives = 125/300 (41%), Gaps = 10/300 (3%)
Query: 95 FKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
FK+L H ++ + ++GSYD T KLWD G + E
Sbjct: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICI 213
++ S+DKT + W +ETGK R T + C F+P V +G +D +
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG-SMDTTAKL 203
Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
D +N V ++ H + I S F+ R+ + S D + +WD + + I H
Sbjct: 204 WDIQNGEEVYTLRGH-SAEIISLSFNTSGDRIITGSFDHTVVVWDADT-GRKVNILIGHC 261
Query: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
IS+ F + + T S DK K+W+ G+ CV + GH+ + F
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGK------CVATLTGHDDEILDSCFDYTG 315
Query: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
+ + D T I+ A L+GH + ++ + +L+ S D+T R+W+ +
Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
Score = 79.3 bits (194), Expect = 7e-15
Identities = 44/175 (25%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFS-GHF 287
H +T+ + + S DR K+WD S L T+ + H N + F G
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL-EGHRNVVYAIAFNNPYGDK 149
Query: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347
+ T S+DK K+W+V TG+ C +GH + F S+ + +G D T +
Sbjct: 150 IATGSFDKTCKLWSVETGK------CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 348 WDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
WD+ G +L+GH+ ++ ++ + + I++ S D T+ +W+ + ++ ++I
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
Score = 63.5 bits (153), Expect = 4e-10
Identities = 35/135 (25%), Positives = 64/135 (47%), Gaps = 7/135 (5%)
Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
L + KAH ++N SG T S+D+ K+W+ +GE N ++GH V
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELN------TLEGHRNVV 137
Query: 325 SSCHFARD-SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
+ F + +G FD+T +W V G + +GH ++ ++ + + + S
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
Query: 384 DRTMRLWNIEEIDEI 398
D T +LW+I+ +E+
Sbjct: 198 DTTAKLWDIQNGEEV 212
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 124 bits (310), Expect = 2e-28
Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L+GH AVS+ F + L S S D +K+W DG + K + + + + DS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
+ +++AS DKT++ WD+ +GK L ++ + ++ C F+P +VSG D + I D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
+ + + H + +++ F+ D + S S D +IWD S L T+ + +
Sbjct: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
S F+ +G ++ ++ D LK+W+ G+ C+ GH+ C FA S
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270
Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
+++SG D V IW++ L+GH D V+ A + I SA+ D+T++LW
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 111 bits (278), Expect = 1e-24
Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)
Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
+ S KFSP+G+++ S D I I A + I H I+ + DS + S
Sbjct: 48 VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105
Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
S D+ +KIWDV+S L T+ K HSN + C F + + + S+D++++IW+V TG+
Sbjct: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162
Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
C+ + H VS+ HF RD S ++S +D IWD A G K + N V
Sbjct: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
V S N K+IL+A+ D T++LW+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242
Score = 100 bits (249), Expect = 3e-21
Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
HT++++S F P+ + +AS S D+ IKIW TI+ H IS+ ++ + L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
++S DK LKIW+V +G+ C+ ++GH V C+F S+ ++SG FD +V IW
Sbjct: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
DV G +L H+D V V + + I+S+S D R+W+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 98.2 bits (243), Expect = 1e-20
Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 24/275 (8%)
Query: 83 IWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH 142
IWG D + K +SGH+ +S + D L+S S D T+K+WD G ++ +
Sbjct: 71 IWGAYDGKFE---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127
Query: 143 RPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYV 201
V C+ S+ +++ S+D++VR WD++TGK L + + VS F+ DG +
Sbjct: 128 HSNY-VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186
Query: 202 V-SGFDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV 259
V S +D G+C I D + + + D ++ F P+ + + + +LD +K+WD
Sbjct: 187 VSSSYD---GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 260 TSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVT 315
+ L T T H N C F FS G ++ + S D + IWN+ T E V
Sbjct: 244 SKGKCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQ 295
Query: 316 LMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
+QGH V ++CH + + D+T+ +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 81.6 bits (200), Expect = 1e-15
Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)
Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
H+ A+S+ F+ +G +L +SS DK +KIW + G+F + GH+ +S ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97
Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
DS+ L+S D+T+ IWDV+ G +LKGH+++V + I+S S D ++R+W+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 392 IE 393
++
Sbjct: 158 VK 159
Score = 56.2 bits (134), Expect = 6e-08
Identities = 24/76 (31%), Positives = 46/76 (60%)
Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
+ GH +VSS F+ + +L S D+ + IW +G + ++ GH + DVA S++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 377 WILSASKDRTMRLWNI 392
++SAS D+T+++W++
Sbjct: 101 LLVSASDDKTLKIWDV 116
Score = 33.5 bits (75), Expect = 0.43
Identities = 13/35 (37%), Positives = 21/35 (60%)
Query: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
K +L GH V V S N +W+ S+S D+ +++W
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 124 bits (310), Expect = 2e-28
Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L+GH AVS+ F + L S S D +K+W DG + K + + + + DS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
+ +++AS DKT++ WD+ +GK L ++ + ++ C F+P +VSG D + I D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
+ + + H + +++ F+ D + S S D +IWD S L T+ + +
Sbjct: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
S F+ +G ++ ++ D LK+W+ G+ C+ GH+ C FA S
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270
Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
+++SG D V IW++ L+GH D V+ A + I SA+ D+T++LW
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 111 bits (278), Expect = 1e-24
Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)
Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
+ S KFSP+G+++ S D I I A + I H I+ + DS + S
Sbjct: 48 VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105
Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
S D+ +KIWDV+S L T+ K HSN + C F + + + S+D++++IW+V TG+
Sbjct: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162
Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
C+ + H VS+ HF RD S ++S +D IWD A G K + N V
Sbjct: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
V S N K+IL+A+ D T++LW+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWD 242
Score = 100 bits (249), Expect = 3e-21
Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
HT++++S F P+ + +AS S D+ IKIW TI+ H IS+ ++ + L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
++S DK LKIW+V +G+ C+ ++GH V C+F S+ ++SG FD +V IW
Sbjct: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
DV G +L H+D V V + + I+S+S D R+W+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 98.2 bits (243), Expect = 1e-20
Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 24/275 (8%)
Query: 83 IWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH 142
IWG D + K +SGH+ +S + D L+S S D T+K+WD G ++ +
Sbjct: 71 IWGAYDGKFE---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127
Query: 143 RPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYV 201
V C+ S+ +++ S+D++VR WD++TGK L + + VS F+ DG +
Sbjct: 128 HSNY-VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186
Query: 202 V-SGFDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV 259
V S +D G+C I D + + + D ++ F P+ + + + +LD +K+WD
Sbjct: 187 VSSSYD---GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 260 TSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVT 315
+ L T T H N C F FS G ++ + S D + IWN+ T E V
Sbjct: 244 SKGKCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQ 295
Query: 316 LMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
+QGH V ++CH + + D+T+ +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 81.6 bits (200), Expect = 1e-15
Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)
Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
H+ A+S+ F+ +G +L +SS DK +KIW + G+F + GH+ +S ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97
Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
DS+ L+S D+T+ IWDV+ G +LKGH+++V + I+S S D ++R+W+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 392 IE 393
++
Sbjct: 158 VK 159
Score = 56.2 bits (134), Expect = 6e-08
Identities = 24/76 (31%), Positives = 46/76 (60%)
Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
+ GH +VSS F+ + +L S D+ + IW +G + ++ GH + DVA S++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 377 WILSASKDRTMRLWNI 392
++SAS D+T+++W++
Sbjct: 101 LLVSASDDKTLKIWDV 116
Score = 33.5 bits (75), Expect = 0.43
Identities = 13/35 (37%), Positives = 21/35 (60%)
Query: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
K +L GH V V S N +W+ S+S D+ +++W
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 122 bits (306), Expect = 7e-28
Identities = 73/238 (30%), Positives = 121/238 (50%), Gaps = 10/238 (4%)
Query: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIM 214
D ++ S D V W+ +G+LLW++ T V C+FSPDG S D + +
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA-SCDCTVRLW 90
Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
D + V+K H RS+ + F PDS+++AS D+ + +WDV S +L + H +
Sbjct: 91 DVARAKCLRVLKGHQ-RSVETVSFSPDSRQLASGGWDKRVMLWDVQS-GQMLRLLVGHRD 148
Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSS-CHFARDS 333
+I + F+ + + L T SWD + IW++ ++GH ++S C+ A S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLR---MVTPAVSHQALEGHSANISCLCYSA--S 203
Query: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
L SG +D+T+ IW + LKGH WV +A S ++ W+ SA R +++W+
Sbjct: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 110 bits (274), Expect = 4e-24
Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 13/296 (4%)
Query: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
K H V++ F D LL+GS D V W+ G ++ PV C +
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT-GPVKFCRFSP 73
Query: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
D +AS D TVR WD+ K L ++ + + + FSPD + + SG D + +
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG-GWDKRVMLW 132
Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV--TSQATLLTITKAH 272
D ++ + ++ H SI S F P +A+ S D + IWD+ + A + H
Sbjct: 133 DVQSGQMLRLLVGHRD-SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARD 332
S IS C++ SG L + SWDK + IW T + ++GH V S F+ D
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL------LIQLKGHVTWVKSIAFSPD 244
Query: 333 SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
+L S G+ R V +WD G +LKG D A + + K ++S + D+T R
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 92.4 bits (228), Expect = 8e-19
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 7/167 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
H + S F PD Q + + S D C+ W+ T LL H+ + C F+ GH
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
++S D +++W+V + C+ +++GH+ SV + F+ DS L SGG+D+ V +W
Sbjct: 79 ASASCDCTVRLWDVARAK------CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 395
DV G L GH D + S + + S D T+ +W++ +
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Score = 64.7 bits (156), Expect = 2e-10
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
H +++ F+ G L T S D + W +G+ + + GH G V C F+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL------LWRLGGHTGPVKFCRFSP 73
Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
D S D TV +WDVA LKGH V V+ S + + + S D+ + LW+
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 392 IEEIDEIPLVIKYKKAV 408
++ + L++ ++ ++
Sbjct: 134 VQSGQMLRLLVGHRDSI 150
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 120 bits (301), Expect = 3e-27
Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)
Query: 96 KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
K+L GH+ V TC FC +++SGS D T+K+W V G +R V S
Sbjct: 256 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 311
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
D+ +I+ S D+T++ W+ ETG+ + + T V C + K VVSG D + +
Sbjct: 312 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 368
Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
D E + V+ H C D +RV S + D +K+WD ++ L T+ + H+N
Sbjct: 369 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 424
Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
+ + F G + + S D ++++W+V TG C+ + GH+ S +
Sbjct: 425 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 474
Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
L+SG D TV IWD+ G +L+G N V + NK +++++S D T++LW+++
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 534
Score = 91.7 bits (226), Expect = 1e-18
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH V H + + +++SGS D T+++WD G + A V C + D
Sbjct: 339 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 393
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
RV++ +YD V+ WD ET L ++ T + S +F DG +VVSG +D I + D
Sbjct: 394 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 450
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
E + + H +S+TS D+ V+ + D +KIWD+ + L T+ + +
Sbjct: 451 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 507
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
+ C F+ +F+ TSS D +K+W++ TGEF RN VTL G G V
Sbjct: 508 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 553
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 120 bits (301), Expect = 3e-27
Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)
Query: 96 KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
K+L GH+ V TC FC +++SGS D T+K+W V G +R V S
Sbjct: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 429
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
D+ +I+ S D+T++ W+ ETG+ + + T V C + K VVSG D + +
Sbjct: 430 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 486
Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
D E + V+ H C D +RV S + D +K+WD ++ L T+ + H+N
Sbjct: 487 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 542
Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
+ + F G + + S D ++++W+V TG C+ + GH+ S +
Sbjct: 543 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 592
Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
L+SG D TV IWD+ G +L+G N V + NK +++++S D T++LW+++
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
Score = 91.7 bits (226), Expect = 1e-18
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH V H + + +++SGS D T+++WD G + A V C + D
Sbjct: 457 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 511
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
RV++ +YD V+ WD ET L ++ T + S +F DG +VVSG +D I + D
Sbjct: 512 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 568
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
E + + H +S+TS D+ V+ + D +KIWD+ + L T+ + +
Sbjct: 569 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
+ C F+ +F+ TSS D +K+W++ TGEF RN VTL G G V
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 671
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 120 bits (301), Expect = 3e-27
Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)
Query: 96 KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
K+L GH+ V TC FC +++SGS D T+K+W V G +R V S
Sbjct: 294 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 349
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
D+ +I+ S D+T++ W+ ETG+ + + T V C + K VVSG D + +
Sbjct: 350 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 406
Query: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
D E + V+ H C D +RV S + D +K+WD ++ L T+ + H+N
Sbjct: 407 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 462
Query: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
+ + F G + + S D ++++W+V TG C+ + GH+ S +
Sbjct: 463 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 512
Query: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
L+SG D TV IWD+ G +L+G N V + NK +++++S D T++LW+++
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 572
Score = 91.7 bits (226), Expect = 1e-18
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH V H + + +++SGS D T+++WD G + A V C + D
Sbjct: 377 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 431
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
RV++ +YD V+ WD ET L ++ T + S +F DG +VVSG +D I + D
Sbjct: 432 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 488
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
E + + H +S+TS D+ V+ + D +KIWD+ + L T+ + +
Sbjct: 489 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 545
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
+ C F+ +F+ TSS D +K+W++ TGEF RN VTL G G V
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 591
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 119 bits (297), Expect = 8e-27
Identities = 78/305 (25%), Positives = 144/305 (47%), Gaps = 10/305 (3%)
Query: 94 PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
P +LSGHE V C F + + L S +D + LW+ V+E
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
Query: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGIC 212
D S + +AS DKTV WD ETG+ + +++ + +F+ SC + G +V D +
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
+ D + ++ T + + F+ S ++ S +D IK+WD+ T+ + H
Sbjct: 178 LWDIRKKAAIQTFQN--TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-RGH 234
Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH----EGSVSSCH 328
+++++ + G +L +++ D +++W+V F CV + QG+ E ++ C
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP--FAPKERCVKIFQGNVHNFEKNLLRCS 292
Query: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
++ D S + +G DR V +WD L GH + +VA ++ I+SAS D+ +
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352
Query: 389 LWNIE 393
+ I+
Sbjct: 353 MGEIQ 357
Score = 62.0 bits (149), Expect = 1e-09
Identities = 31/83 (37%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Query: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV-AEGYRKLSLKGHNDWVMDVA 370
A + L+ GHEG V C F + S L S GFDR + +W+V + +LKGH+ VM++
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
Query: 371 ISNNKKWILSASKDRTMRLWNIE 393
+ + + SAS D+T+ +W+ E
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSE 139
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 119 bits (297), Expect = 8e-27
Identities = 81/300 (27%), Positives = 143/300 (47%), Gaps = 17/300 (5%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH AVS+ F + L S S D + +W DG + + + + + + DS
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDS 95
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
SR+++AS DKT++ WD+ +GK L ++ + ++ C F+P ++SG D + I +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG-SFDETVKIWEV 154
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
+ + + H + +++ F+ + S S D +IWD S L T+ + +
Sbjct: 155 KTGKCLKTLSAH-SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
S F+ +G ++ T++ D LK+W+ G C+ GH+ C FA S
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGR------CLKTYTGHKNE-KYCIFANFSVTG 266
Query: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
+++SG D V IW++ L+GH D V+ A + I SA+ D+T++LW
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 110 bits (274), Expect = 4e-24
Identities = 69/204 (33%), Positives = 105/204 (51%), Gaps = 10/204 (4%)
Query: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
+ S KFSP+G+++ S D I I A + + H+ I+ + DS R+ S
Sbjct: 44 VSSVKFSPNGEWLASS-SADRLIIIWGAYDGKYEKTLYGHNLE-ISDVAWSSDSSRLVSA 101
Query: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
S D+ +K+WDV S L T+ K HSN + C F + + + S+D+ +KIW V TG+
Sbjct: 102 SDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK-- 158
Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
C+ + H VS+ HF S ++SG +D IWD A G K + N V
Sbjct: 159 ----CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
V S N K+IL+A+ D T++LW+
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWD 238
Score = 99.4 bits (246), Expect = 6e-21
Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 24/276 (8%)
Query: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
+IWG D + K L GH +S + D ++L+S S D T+KLWD G ++ +
Sbjct: 66 IIWGAYDGKYE---KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK 122
Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKY 200
V C+ S+ +I+ S+D+TV+ W+++TGK L + + VS F+ G
Sbjct: 123 GHSNY-VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 201 VVSG-FDVDHGIC-IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 258
+VSG +D G+C I DA + + + D ++ F P+ + + + +LD +K+WD
Sbjct: 182 IVSGSYD---GLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 259 VTSQATLLTITKAHSNAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACV 314
+ L T T H N C F FS G ++ + S D + IWN+ T E V
Sbjct: 239 YSRGRCLKTYT-GHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------V 290
Query: 315 TLMQGHEGSV--SSCHFARDSSFLISGGFDRTVAIW 348
+QGH V ++CH + + D+T+ +W
Sbjct: 291 QKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 92.4 bits (228), Expect = 8e-19
Identities = 55/163 (33%), Positives = 86/163 (52%), Gaps = 7/163 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
HT +++S F P+ + +AS S DR I IW T+ H+ IS+ ++ L
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSRL 98
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
++S DK LK+W+V +G+ C+ ++GH V C+F S+ +ISG FD TV IW
Sbjct: 99 VSASDDKTLKLWDVRSGK------CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
+V G +L H+D V V + + I+S S D R+W+
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/155 (27%), Positives = 82/155 (52%), Gaps = 7/155 (4%)
Query: 239 DPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLK 298
D +Q S S ++ ++ + + A T+ H+ A+S+ F+ +G +L +SS D+ +
Sbjct: 8 DAKAQLALSSSANQSKEVPENPNYALKCTLV-GHTEAVSSVKFSPNGEWLASSSADRLII 66
Query: 299 IWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLS 358
IW + G++ + GH +S ++ DSS L+S D+T+ +WDV G +
Sbjct: 67 IWGAYDGKYEKT------LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120
Query: 359 LKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
LKGH+++V + I+S S D T+++W ++
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 112 bits (279), Expect = 9e-25
Identities = 80/252 (31%), Positives = 119/252 (47%), Gaps = 13/252 (5%)
Query: 99 SGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDP-VDGSVVRDFEHRPKAPVVECSITGDS 157
+GH+ AV+ +F L SGS D TV++W P V G H A V D
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH--TATVRSVHFCSDG 77
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICIMDA 216
+ AS DKTV+ W K L+ + V C KFSPDG+ +VS D D + + D
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-DKTVKLWDK 136
Query: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
+ V + H +T F P +A+ +D +K+WDV + LL + HS A+
Sbjct: 137 SSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAV 194
Query: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFL 336
+ F SG++L T+S D LKI ++ G + + GH+G ++ F+R +
Sbjct: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRL------LYTLHGHQGPATTVAFSRTGEYF 248
Query: 337 ISGGFDRTVAIW 348
SGG D V +W
Sbjct: 249 ASGGSDEQVMVW 260
Score = 79.3 bits (194), Expect = 7e-15
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)
Query: 250 LDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRN 309
+D C+ +W + Q+ T H +A++ F+ SGH L + S DK ++IW N
Sbjct: 1 MDSCLMVWHMKPQSRAYRFT-GHKDAVTCVNFSPSGHLLASGSRDKTVRIW------VPN 53
Query: 310 CGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV 369
T+ + H +V S HF D ++ D+TV +W SL H +WV
Sbjct: 54 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 113
Query: 370 AISNNKKWILSASKDRTMRLWN 391
S + + I+SAS D+T++LW+
Sbjct: 114 KFSPDGRLIVSASDDKTVKLWD 135
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 101 bits (252), Expect = 1e-21
Identities = 72/268 (26%), Positives = 123/268 (45%), Gaps = 30/268 (11%)
Query: 145 KAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVS 203
++PV S +++AS D T++ WD ETG ++ T V F GK + S
Sbjct: 108 RSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLAS 167
Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
D I + D + + + H +++S P+ + S S D+ IK+W+V +
Sbjct: 168 -CSADMTIKLWDFQGFECIRTMHGHD-HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
+ T T H + G + + S D+ +++W V T E C ++ HE
Sbjct: 226 CVKTFT-GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE------CKAELREHEHV 278
Query: 324 VSSCHFARDSS--------------------FLISGGFDRTVAIWDVAEGYRKLSLKGHN 363
V +A +SS FL+SG D+T+ +WDV+ G ++L GH+
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 364 DWVMDVAISNNKKWILSASKDRTMRLWN 391
+WV V + K+ILS + D+T+R+W+
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWD 366
Score = 90.9 bits (224), Expect = 2e-18
Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 7/162 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
H +T F P + S S D IK+WD + T+ K H++++ + F SG L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL-KGHTDSVQDISFDHSGKLL 165
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
+ S D +K+W+ E C+ M GH+ +VSS + ++S D+T+ +W
Sbjct: 166 ASCSADMTIKLWDFQGFE------CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
+V GY + GH +WV V + + I S S D+T+R+W
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 90.1 bits (222), Expect = 4e-18
Identities = 63/256 (24%), Positives = 120/256 (46%), Gaps = 35/256 (13%)
Query: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE-HRPKAPVVECSIT 154
+ + GH+H VS+ + ++S S D T+K+W+ G V+ F HR +V +
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN-- 243
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICI 213
D + + + S D+TVR W + T + ++R +V C ++P+ Y
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSY------------- 290
Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
+++S T+ + S S D+ IK+WDV++ L+T+ H
Sbjct: 291 ------SSISEATGSETKK-----SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV-GHD 338
Query: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
N + F G F+ + + DK L++W +++N C+ + HE V+S F + +
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVW-----DYKN-KRCMKTLNAHEHFVTSLDFHKTA 392
Query: 334 SFLISGGFDRTVAIWD 349
++++G D+TV +W+
Sbjct: 393 PYVVTGSVDQTVKVWE 408
Score = 89.0 bits (219), Expect = 9e-18
Identities = 73/319 (22%), Positives = 135/319 (42%), Gaps = 41/319 (12%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA---PVVECSIT 154
LSGH V+ F + ++S S D T+K+WD G DFE K V + S
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG----DFERTLKGHTDSVQDISFD 159
Query: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICI 213
+ + S D T++ WD + + + + +D + S P+G ++VS D I +
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA-SRDKTIKM 218
Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
+ + V H + + D +AS S D+ +++W V ++ + + H
Sbjct: 219 WEVQTGYCVKTFTGHR-EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL-REHE 276
Query: 274 NAISNCCFTFS----------------------GHFLCTSSWDKNLKIWNVHTGEFRNCG 311
+ + C +++ G FL + S DK +K+W+V TG
Sbjct: 277 HVVE--CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG------ 328
Query: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAI 371
C+ + GH+ V F F++S D+T+ +WD +L H +V +
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDF 388
Query: 372 SNNKKWILSASKDRTMRLW 390
++++ S D+T+++W
Sbjct: 389 HKTAPYVVTGSVDQTVKVW 407
Score = 63.9 bits (154), Expect = 3e-10
Identities = 35/123 (28%), Positives = 63/123 (51%), Gaps = 8/123 (6%)
Query: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
H + ++ F + ++S D +K+W+ TG+F ++GH SV F
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT------LKGHTDSVQDISFDH 160
Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKL-SLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
L S D T+ +WD +G+ + ++ GH+ V VAI N I+SAS+D+T+++W
Sbjct: 161 SGKLLASCSADMTIKLWDF-QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 391 NIE 393
++
Sbjct: 220 EVQ 222
Score = 55.5 bits (132), Expect = 1e-07
Identities = 25/77 (32%), Positives = 42/77 (54%)
Query: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
+ GH V+ F S ++S D T+ +WD G + +LKGH D V D++ ++ K
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 377 WILSASKDRTMRLWNIE 393
+ S S D T++LW+ +
Sbjct: 164 LLASCSADMTIKLWDFQ 180
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/43 (37%), Positives = 25/43 (58%)
Query: 88 DPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWD 130
D +K K L+ HEH V++ F +++GS D TVK+W+
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 99.8 bits (247), Expect = 5e-21
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646
Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699
Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759
Query: 380 SASKDRTMRLWNIEEIDE 397
S S D T++LW+ +E
Sbjct: 760 SCSADGTLKLWDATSANE 777
Score = 84.3 bits (207), Expect = 2e-16
Identities = 77/343 (22%), Positives = 144/343 (41%), Gaps = 60/343 (17%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
GH ++V+ C F DD L S S D T+KLWD + + D + +
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
Query: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
V CS + D +R++ A+ +K + W+ ++ + R + +++ FSPDG ++ D
Sbjct: 801 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
Query: 207 VDHGICIMDAENITTVSVIK-------------------DHHTR---------------- 231
D I + + + + S + DH R
Sbjct: 860 -DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 918
Query: 232 -SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
++ CC P Q +A + I+I ++ + + + H + + FT L +
Sbjct: 919 AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLIS 977
Query: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
SS D +++WN + C+ L +GH+ +V ++S L+S FD TV +W++
Sbjct: 978 SSDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNI 1029
Query: 351 AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
G ++ H V+ IS++ S S D+T ++W+ +
Sbjct: 1030 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1072
Score = 70.1 bits (170), Expect = 4e-12
Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)
Query: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307
S +I + I CC ++ G + ++ +K + +WN + +
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 832
Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
+C +GH V F+ D S ++ D+T+ +W+ + + ++ + +
Sbjct: 833 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 883
Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
DV N+ +L+ R ++L N
Sbjct: 884 DVVFQENEVMVLAVDHIRRLQLIN 907
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 997 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1054
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1113
Query: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
N + + H +T CF PD + + +S IK W+V +
Sbjct: 1114 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1163
Score = 59.3 bits (142), Expect = 7e-09
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 893
Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 894 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 949
Query: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 950 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1007
Query: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 1008 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1066
Query: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 1067 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1126
Query: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 1127 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1161
Score = 29.6 bits (65), Expect = 6.2
Identities = 13/45 (28%), Positives = 23/45 (51%)
Query: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
+P L GH V F VD T L +G + +++W+ +G ++
Sbjct: 1075 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1119
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 99.8 bits (247), Expect = 5e-21
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646
Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699
Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759
Query: 380 SASKDRTMRLWNIEEIDE 397
S S D T++LW+ +E
Sbjct: 760 SCSADGTLKLWDATSANE 777
Score = 86.3 bits (212), Expect = 6e-17
Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)
Query: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
S +I + I CC ++ G + ++ +K + ++++HT
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 829
Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368
G + GH ++ C F+ + + V +W+ + +GH WV
Sbjct: 830 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 887
Query: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395
V S + L++S D+T+RLW +++
Sbjct: 888 VMFSPDGSSFLTSSDDQTIRLWETKKV 914
Score = 74.3 bits (181), Expect = 2e-13
Identities = 81/386 (20%), Positives = 145/386 (37%), Gaps = 103/386 (26%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
GH ++V+ C F DD L S S D T+KLWD + + D + +
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
Query: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLL--------------------------- 180
V CS + D +R++ A+ +K + +D+ T LL
Sbjct: 801 VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859
Query: 181 -------WKVRYDTFIVSCK----------FSPDGKYVVSGFDVDHGICIMDAENITTVS 223
W + + C+ FSPDG ++ D D I + + + + S
Sbjct: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKNS 918
Query: 224 VIK-------------------DHHTR-----------------SITSCCFDPDSQRVAS 247
+ DH R ++ CC P Q +A
Sbjct: 919 AVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAF 978
Query: 248 VSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF 307
+ I+I ++ + + + H + + FT L +SS D +++WN +
Sbjct: 979 GDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK- 1036
Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
C+ L +GH+ +V ++S L+S FD TV +W++ G ++ H V+
Sbjct: 1037 -----CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL 1089
Query: 368 DVAISNNKKWILSASKDRTMRLWNIE 393
IS++ S S D+T ++W+ +
Sbjct: 1090 SCDISHDATKFSSTSADKTAKIWSFD 1115
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 1040 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1097
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 1098 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1156
Query: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
N + + H +T CF PD + + +S IK W+V +
Sbjct: 1157 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1206
Score = 59.3 bits (142), Expect = 7e-09
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 936
Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 937 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 992
Query: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 993 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1050
Query: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 1051 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109
Query: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 1110 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1169
Query: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 1170 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1204
Score = 29.6 bits (65), Expect = 6.2
Identities = 13/45 (28%), Positives = 23/45 (51%)
Query: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
+P L GH V F VD T L +G + +++W+ +G ++
Sbjct: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 99.8 bits (247), Expect = 5e-21
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635
Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688
Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
Query: 380 SASKDRTMRLWNIEEIDE 397
S S D T++LW+ +E
Sbjct: 749 SCSADGTLKLWDATSANE 766
Score = 84.3 bits (207), Expect = 2e-16
Identities = 77/343 (22%), Positives = 144/343 (41%), Gaps = 60/343 (17%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
GH ++V+ C F DD L S S D T+KLWD + + D + +
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
Query: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
V CS + D +R++ A+ +K + W+ ++ + R + +++ FSPDG ++ D
Sbjct: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
Query: 207 VDHGICIMDAENITTVSVIK-------------------DHHTR---------------- 231
D I + + + + S + DH R
Sbjct: 849 -DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 907
Query: 232 -SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
++ CC P Q +A + I+I ++ + + + H + + FT L +
Sbjct: 908 AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLIS 966
Query: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
SS D +++WN + C+ L +GH+ +V ++S L+S FD TV +W++
Sbjct: 967 SSDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNI 1018
Query: 351 AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
G ++ H V+ IS++ S S D+T ++W+ +
Sbjct: 1019 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1061
Score = 70.1 bits (170), Expect = 4e-12
Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)
Query: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307
S +I + I CC ++ G + ++ +K + +WN + +
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 821
Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
+C +GH V F+ D S ++ D+T+ +W+ + + ++ + +
Sbjct: 822 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 872
Query: 368 DVAISNNKKWILSASKDRTMRLWN 391
DV N+ +L+ R ++L N
Sbjct: 873 DVVFQENEVMVLAVDHIRRLQLIN 896
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 986 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1043
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1102
Query: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
N + + H +T CF PD + + +S IK W+V +
Sbjct: 1103 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1152
Score = 59.3 bits (142), Expect = 7e-09
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 882
Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 883 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 938
Query: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 939 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 996
Query: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 997 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1055
Query: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 1056 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1115
Query: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 1116 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1150
Score = 29.6 bits (65), Expect = 6.2
Identities = 13/45 (28%), Positives = 23/45 (51%)
Query: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
+P L GH V F VD T L +G + +++W+ +G ++
Sbjct: 1064 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1108
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 99.8 bits (247), Expect = 5e-21
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635
Query: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688
Query: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
Query: 380 SASKDRTMRLWNIEEIDE 397
S S D T++LW+ +E
Sbjct: 749 SCSADGTLKLWDATSANE 766
Score = 86.3 bits (212), Expect = 6e-17
Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)
Query: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
Query: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
S +I + I CC ++ G + ++ +K + ++++HT
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 818
Query: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368
G + GH ++ C F+ + + V +W+ + +GH WV
Sbjct: 819 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 876
Query: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395
V S + L++S D+T+RLW +++
Sbjct: 877 VMFSPDGSSFLTSSDDQTIRLWETKKV 903
Score = 74.3 bits (181), Expect = 2e-13
Identities = 81/386 (20%), Positives = 145/386 (37%), Gaps = 103/386 (26%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
GH ++V+ C F DD L S S D T+KLWD + + D + +
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
Query: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLL--------------------------- 180
V CS + D +R++ A+ +K + +D+ T LL
Sbjct: 790 VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
Query: 181 -------WKVRYDTFIVSCK----------FSPDGKYVVSGFDVDHGICIMDAENITTVS 223
W + + C+ FSPDG ++ D D I + + + + S
Sbjct: 849 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKNS 907
Query: 224 VIK-------------------DHHTR-----------------SITSCCFDPDSQRVAS 247
+ DH R ++ CC P Q +A
Sbjct: 908 AVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAF 967
Query: 248 VSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF 307
+ I+I ++ + + + H + + FT L +SS D +++WN +
Sbjct: 968 GDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK- 1025
Query: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
C+ L +GH+ +V ++S L+S FD TV +W++ G ++ H V+
Sbjct: 1026 -----CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL 1078
Query: 368 DVAISNNKKWILSASKDRTMRLWNIE 393
IS++ S S D+T ++W+ +
Sbjct: 1079 SCDISHDATKFSSTSADKTAKIWSFD 1104
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 1029 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1086
Query: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1145
Query: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
N + + H +T CF PD + + +S IK W+V +
Sbjct: 1146 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1195
Score = 59.3 bits (142), Expect = 7e-09
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 925
Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 926 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 981
Query: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 982 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1039
Query: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 1040 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
Query: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158
Query: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1193
Score = 29.6 bits (65), Expect = 6.2
Identities = 13/45 (28%), Positives = 23/45 (51%)
Query: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVV 137
+P L GH V F VD T L +G + +++W+ +G ++
Sbjct: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 97.8 bits (242), Expect = 2e-20
Identities = 55/173 (31%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
HT ++ CCF P ++A+ S D +K+WD+ +LT + HS A+ +C + G+F+
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTF-EGHSRAVWSCTWHSCGNFV 451
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
+SS DK KIW+V N C + GH SV+S F S+ L++ D+T++IW
Sbjct: 452 ASSSLDKTSKIWDV------NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLV 401
D G + SL GH + D I S +LW+ ++ +P+V
Sbjct: 506 DARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKL--LPIV 556
Score = 84.7 bits (208), Expect = 2e-16
Identities = 72/251 (28%), Positives = 107/251 (42%), Gaps = 14/251 (5%)
Query: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
GH +S C F KL + S D TVKLWD G + FE +A V C+ +
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRA-VWSCTWHSCGNF 450
Query: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGFDVDHGICIMDAE- 217
V ++S DKT + WD+ + + + T V S +F P +++ D + I DA
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTS-SADKTLSIWDART 509
Query: 218 NITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAIS 277
I S+ H SI FDP +AS K+WD +++I S +
Sbjct: 510 GICEQSLY--GHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPG-N 566
Query: 278 NCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLI 337
F SG L +S + + + ++ +GE + GHE + F+ D L
Sbjct: 567 EVNFDSSGRVLAQASGNGVIHLLDLKSGEIHK-------LMGHENEAHTVVFSHDGEILF 619
Query: 338 SGGFDRTVAIW 348
SGG D TV W
Sbjct: 620 SGGSDGTVRTW 630
Score = 82.4 bits (202), Expect = 8e-16
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 7/163 (4%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
H ++ P + S DR K+ + LLT H++ +S+CCF SG L
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLT-GFGHTDWLSDCCFHPSGDKL 409
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
TSS D +K+W++ G+ C+ +GH +V SC + +F+ S D+T IW
Sbjct: 410 ATSSGDTTVKLWDLCKGD------CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW 463
Query: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
DV + +L GH D V + +L++S D+T+ +W+
Sbjct: 464 DVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
Score = 62.0 bits (149), Expect = 1e-09
Identities = 62/266 (23%), Positives = 98/266 (36%), Gaps = 74/266 (27%)
Query: 179 LLWKVRYDTFIVSCKFSPDGKYVVSG--------FDVDHGICIMDAENITTVSVIKDHHT 230
LL + ++ C F P G + + +D+ G CI+ E H+
Sbjct: 387 LLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEG----------HS 436
Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
R++ SC + VAS SLD+ KIWDV S+ T+ H++++++ F + L T
Sbjct: 437 RAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLY-GHTDSVNSIEFFPFSNTLLT 495
Query: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
SS DK L IW+ TG C + GH S++ F + S +WD
Sbjct: 496 SSADKTLSIWDARTG------ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD- 548
Query: 351 AEGYRKL---------------------------------------------SLKGHNDW 365
+RKL L GH +
Sbjct: 549 ---FRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENE 605
Query: 366 VMDVAISNNKKWILSASKDRTMRLWN 391
V S++ + + S D T+R W+
Sbjct: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/74 (28%), Positives = 38/74 (51%)
Query: 319 GHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWI 378
GH +S C F L + D TV +WD+ +G L+ +GH+ V + ++
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
Query: 379 LSASKDRTMRLWNI 392
S+S D+T ++W++
Sbjct: 452 ASSSLDKTSKIWDV 465
Score = 35.4 bits (80), Expect = 0.11
Identities = 24/89 (26%), Positives = 41/89 (46%)
Query: 320 HEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
HE VS L+S G DR + + + L+ GH DW+ D + +
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 380 SASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
++S D T++LW++ + D I + +AV
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAV 439
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 96.3 bits (238), Expect = 5e-20
Identities = 76/282 (26%), Positives = 124/282 (43%), Gaps = 25/282 (8%)
Query: 113 DDTKLLSGSY-DCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRA 171
DD+ L++G + D TV++W V +R + D S + S D R
Sbjct: 480 DDSSLIAGGFADSTVRVWS-VTPKKLRSVKQ-----------ASDLSLIDKESDDVLERI 527
Query: 172 WDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHH 229
D +T L K+ Y + FSPD Y++S + D + + + T + K H+
Sbjct: 528 MDEKTASEL-KILYGHSGPVYGASFSPDRNYLLSSSE-DGTVRLWSLQTFTCLVGYKGHN 585
Query: 230 TRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLC 289
+ F P S DR ++W T L I H ++ F + +++
Sbjct: 586 Y-PVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 290 TSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWD 349
T S D+ +++W+V G CV + GH+G + S F+ + FL +G D V +WD
Sbjct: 644 TGSADRTVRLWDVLNGN------CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 350 VAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
+ G LKGH D V + S + + + S S D T+RLW+
Sbjct: 698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 95.1 bits (235), Expect = 1e-19
Identities = 63/212 (29%), Positives = 101/212 (47%), Gaps = 10/212 (4%)
Query: 147 PVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGF 205
PV S + D + ++++S D TVR W L+T L + + V +FSP G Y VSG
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
Query: 206 DVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
D + ++ + + H + F P+S VA+ S DR +++WDV +
Sbjct: 605 H-DRVARLWATDHYQPLRIFAGH-LADVNCTRFHPNSNYVATGSADRTVRLWDVLN-GNC 661
Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVS 325
+ I H I + F+ +G FL T + D + +W++ G V ++GH +V
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI------GHGLMVGELKGHTDTVC 715
Query: 326 SCHFARDSSFLISGGFDRTVAIWDVAEGYRKL 357
S F+RD L SG D TV +WD + + L
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747
Score = 75.1 bits (183), Expect = 1e-13
Identities = 59/241 (24%), Positives = 104/241 (43%), Gaps = 21/241 (8%)
Query: 153 ITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGIC 212
+T DSS + D TVR W + KL S K + D + D D
Sbjct: 478 VTDDSSLIAGGFADSTVRVWSVTPKKLR----------SVKQASDLSLIDKESD-DVLER 526
Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
IMD + + + ++ H + + F PD + S S D +++W + + T L K H
Sbjct: 527 IMDEKTASELKILYGH-SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-FTCLVGYKGH 584
Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNV-HTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
+ + + F+ G++ + D+ ++W H R + GH V+ F
Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-------IFAGHLADVNCTRFHP 637
Query: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
+S+++ +G DRTV +WDV G GH + + S N +++ + + D + LW+
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 392 I 392
I
Sbjct: 698 I 698
Score = 67.4 bits (163), Expect = 3e-11
Identities = 56/229 (24%), Positives = 102/229 (44%), Gaps = 9/229 (3%)
Query: 74 EKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVD 133
E V E+++ D+ S++ KIL GH V F D LLS S D TV+LW
Sbjct: 519 ESDDVLERIM--DEKTASEL--KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT 574
Query: 134 GSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC- 192
+ + ++ PV + + ++ +D+ R W + + L V+C
Sbjct: 575 FTCLVGYKGH-NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633
Query: 193 KFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDR 252
+F P+ YV +G D + + D N V + H I S F P+ + +A+ + D
Sbjct: 634 RFHPNSNYVATG-SADRTVRLWDVLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDG 691
Query: 253 CIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWN 301
+ +WD+ ++ K H++ + + F+ G L + S D +++W+
Sbjct: 692 RVLLWDI-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 57.0 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 3/124 (2%)
Query: 94 PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
P +I +GH V+ F + + +GS D TV+LWD ++G+ VR F K P+ +
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH-KGPIHSLTF 677
Query: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDT-FIVSCKFSPDGKYVVSGFDVDHGIC 212
+ + + + D V WD+ G ++ +++ T + S +FS DG+ + SG +D+ +
Sbjct: 678 SPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG-SMDNTVR 736
Query: 213 IMDA 216
+ DA
Sbjct: 737 LWDA 740
Score = 35.0 bits (79), Expect = 0.15
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 36/96 (37%)
Query: 332 DSSFLISGGF-DRTVAIWDVAEGYRKLS-------------------------------- 358
D S LI+GGF D TV +W V +KL
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTP--KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELK 537
Query: 359 -LKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
L GH+ V + S ++ ++LS+S+D T+RLW+++
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
Score = 33.5 bits (75), Expect = 0.43
Identities = 16/35 (45%), Positives = 19/35 (54%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPV 132
L GH V + F D L SGS D TV+LWD +
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 94.4 bits (233), Expect = 2e-19
Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
DD K++SG D ++K+WD ++ + V C + D ++ S D TVR W
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 305
Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D+ TG++L + ++ ++ +FS +G V D I + D + T +++ +
Sbjct: 306 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 362
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
D D + + S S DR IK+W TS + H I+ C + + +
Sbjct: 363 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 419
Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
S D +++W++ CGAC+ +++GHE V F D+ ++SG +D + +WD+
Sbjct: 420 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 471
Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
A +L H+ V + + I+S+S D T+ +W+
Sbjct: 472 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 518
Score = 74.7 bits (182), Expect = 2e-13
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)
Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
C D +++ S D IKIWD TS L +T H+ ++ C + + T S D
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 301
Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
+++W+V+TGE N TL+ +E + H + +++ DR++A+WD+A
Sbjct: 302 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 353
Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
+ L GH V + + K+I+SAS DRT+++W+ + + + +K+ +
Sbjct: 354 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 406
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 94.4 bits (233), Expect = 2e-19
Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
DD K++SG D ++K+WD ++ + V C + D ++ S D TVR W
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 271
Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D+ TG++L + ++ ++ +FS +G V D I + D + T +++ +
Sbjct: 272 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 328
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
D D + + S S DR IK+W TS + H I+ C + + +
Sbjct: 329 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 385
Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
S D +++W++ CGAC+ +++GHE V F D+ ++SG +D + +WD+
Sbjct: 386 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 437
Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
A +L H+ V + + I+S+S D T+ +W+
Sbjct: 438 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 484
Score = 74.7 bits (182), Expect = 2e-13
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)
Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
C D +++ S D IKIWD TS L +T H+ ++ C + + T S D
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 267
Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
+++W+V+TGE N TL+ +E + H + +++ DR++A+WD+A
Sbjct: 268 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 319
Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
+ L GH V + + K+I+SAS DRT+++W+ + + + +K+ +
Sbjct: 320 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 372
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 94.4 bits (233), Expect = 2e-19
Identities = 72/289 (24%), Positives = 132/289 (45%), Gaps = 29/289 (10%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
DD K++SG D ++K+WD ++ + V C + D ++ S D TVR W
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS--VLC-LQYDERVIVTGSSDSTVRVW 292
Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D+ TG++L + ++ ++ +FS +G V D I + D + T +++ +
Sbjct: 293 DVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTC--SKDRSIAVWDMASATDITLRRVLVGH 349
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
D D + + S S DR IK+W TS + H I+ C + + +
Sbjct: 350 RAAVNVVDFDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 406
Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV- 350
S D +++W++ CGAC+ +++GHE V F D+ ++SG +D + +WD+
Sbjct: 407 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQ 458
Query: 351 --------AEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
A +L H+ V + + I+S+S D T+ +W+
Sbjct: 459 AALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 505
Score = 74.7 bits (182), Expect = 2e-13
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 16/175 (9%)
Query: 237 CFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKN 296
C D +++ S D IKIWD TS L +T H+ ++ C + + T S D
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSV--LCLQYDERVIVTGSSDST 288
Query: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG--- 353
+++W+V+TGE N TL+ +E + H + +++ DR++A+WD+A
Sbjct: 289 VRVWDVNTGEVLN-----TLIHHNEAVL---HLRFSNGLMVTCSKDRSIAVWDMASATDI 340
Query: 354 YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
+ L GH V + + K+I+SAS DRT+++W+ + + + +K+ +
Sbjct: 341 TLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 393
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 92.4 bits (228), Expect = 8e-19
Identities = 79/315 (25%), Positives = 137/315 (43%), Gaps = 20/315 (6%)
Query: 87 QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
+DP + FK GH AV+ F ++ +L SGS D + +W S R +
Sbjct: 7 EDPSLERHFK---GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHK 61
Query: 147 PVVECSITGDSSRVIAA-SYDKTVRAW--DLETGKLLWKVRYDTFIVSCKFSPDGKYVVS 203
V C S ++A+ S DKTVR W +++ +++ T + S F DG+ V+
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-VRSVHFCSDGQSFVT 120
Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
D D + + + + H + F PD + + S S D+ +K+WD +S+
Sbjct: 121 ASD-DKTVKVWATHRQKFLFSLSQH-INWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
+ + + H ++ F SG + + D +K+W+V T + Q H +
Sbjct: 179 CVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL------LQHYQLHSAA 231
Query: 324 VSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
V+ F ++LI+ D T+ I D+ EG +L GH VA S ++ S
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 384 DRTMRLW--NIEEID 396
D + +W N + +D
Sbjct: 292 DEQVMVWKSNFDIVD 306
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 92.4 bits (228), Expect = 8e-19
Identities = 79/315 (25%), Positives = 137/315 (43%), Gaps = 20/315 (6%)
Query: 87 QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
+DP + FK GH AV+ F ++ +L SGS D + +W S R +
Sbjct: 7 EDPSLERHFK---GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHK 61
Query: 147 PVVECSITGDSSRVIAA-SYDKTVRAW--DLETGKLLWKVRYDTFIVSCKFSPDGKYVVS 203
V C S ++A+ S DKTVR W +++ +++ T + S F DG+ V+
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-VRSVHFCSDGQSFVT 120
Query: 204 GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQA 263
D D + + + + H + F PD + + S S D+ +K+WD +S+
Sbjct: 121 ASD-DKTVKVWATHRQKFLFSLSQH-INWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 264 TLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGS 323
+ + + H ++ F SG + + D +K+W+V T + Q H +
Sbjct: 179 CVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL------LQHYQLHSAA 231
Query: 324 VSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
V+ F ++LI+ D T+ I D+ EG +L GH VA S ++ S
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 384 DRTMRLW--NIEEID 396
D + +W N + +D
Sbjct: 292 DEQVMVWKSNFDIVD 306
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 92.0 bits (227), Expect = 1e-18
Identities = 73/289 (25%), Positives = 130/289 (44%), Gaps = 29/289 (10%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
DD K++SG D T+K+WD R + V C + D +I S D TVR W
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS--VLC-LQYDERVIITGSSDSTVRVW 332
Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D+ TG++L + + ++ +F+ +G V D I + D + T +++ +
Sbjct: 333 DVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTC--SKDRSIAVWDMASPTDITLRRVLVGH 389
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
D D + + S S DR IK+W+ TS + H I+ C + + +
Sbjct: 390 RAAVNVVDFDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 446
Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351
S D +++W++ CGAC+ +++GHE V F D+ ++SG +D + +WD+
Sbjct: 447 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLV 498
Query: 352 EGYRKLSLKG---------HNDWVMDVAISNNKKWILSASKDRTMRLWN 391
+ G H+ V + + I+S+S D T+ +W+
Sbjct: 499 AALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 545
Score = 73.2 bits (178), Expect = 5e-13
Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 19/186 (10%)
Query: 229 HTRSITS---CCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSG 285
H RS TS C D Q++ S D IKIWD + +T H+ ++ C +
Sbjct: 261 HCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDE 317
Query: 286 HFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTV 345
+ T S D +++W+V+TGE N TL+ E + H ++ +++ DR++
Sbjct: 318 RVIITGSSDSTVRVWDVNTGEMLN-----TLIHHCEAVL---HLRFNNGMMVTCSKDRSI 369
Query: 346 AIWDVAEGYR---KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
A+WD+A + L GH V V + K+I+SAS DRT+++WN + + +
Sbjct: 370 AVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNTSTCEFVRTLN 427
Query: 403 KYKKAV 408
+K+ +
Sbjct: 428 GHKRGI 433
Score = 68.6 bits (166), Expect = 1e-11
Identities = 60/244 (24%), Positives = 113/244 (46%), Gaps = 32/244 (13%)
Query: 163 ASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSP---------DGKYVVSGFDVDHGIC 212
A Y K ++ D+ET + W+ R+ + C+ D + +VSG D+ I
Sbjct: 234 ALYPKIIQ--DIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLR-DNTIK 290
Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
I D + ++ H T S+ C D + + + S D +++WDV + L T+ H
Sbjct: 291 IWDKNTLECKRILTGH-TGSVL--CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-H 346
Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQ---GHEGSVSSCHF 329
A+ + F+ + T S D+++ +W++ + +TL + GH +V+ F
Sbjct: 347 CEAVLH--LRFNNGMMVTCSKDRSIAVWDMASP------TDITLRRVLVGHRAAVNVVDF 398
Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
D +++S DRT+ +W+ + +L GH + + + ++S S D T+RL
Sbjct: 399 --DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRL 454
Query: 390 WNIE 393
W+IE
Sbjct: 455 WDIE 458
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 92.0 bits (227), Expect = 1e-18
Identities = 73/289 (25%), Positives = 130/289 (44%), Gaps = 29/289 (10%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
DD K++SG D T+K+WD R + V C + D +I S D TVR W
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS--VLC-LQYDERVIITGSSDSTVRVW 368
Query: 173 DLETGKLL-WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D+ TG++L + + ++ +F+ +G V D I + D + T +++ +
Sbjct: 369 DVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTC--SKDRSIAVWDMASPTDITLRRVLVGH 425
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
D D + + S S DR IK+W+ TS + H I+ C + + +
Sbjct: 426 RAAVNVVDFDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHKRGIA--CLQYRDRLVVSG 482
Query: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351
S D +++W++ CGAC+ +++GHE V F D+ ++SG +D + +WD+
Sbjct: 483 SSDNTIRLWDI------ECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLV 534
Query: 352 EGYRKLSLKG---------HNDWVMDVAISNNKKWILSASKDRTMRLWN 391
+ G H+ V + + I+S+S D T+ +W+
Sbjct: 535 AALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 581
Score = 73.2 bits (178), Expect = 5e-13
Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 19/186 (10%)
Query: 229 HTRSITS---CCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSG 285
H RS TS C D Q++ S D IKIWD + +T H+ ++ C +
Sbjct: 297 HCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILT-GHTGSV--LCLQYDE 353
Query: 286 HFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTV 345
+ T S D +++W+V+TGE N TL+ E + H ++ +++ DR++
Sbjct: 354 RVIITGSSDSTVRVWDVNTGEMLN-----TLIHHCEAVL---HLRFNNGMMVTCSKDRSI 405
Query: 346 AIWDVAEGYR---KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
A+WD+A + L GH V V + K+I+SAS DRT+++WN + + +
Sbjct: 406 AVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNTSTCEFVRTLN 463
Query: 403 KYKKAV 408
+K+ +
Sbjct: 464 GHKRGI 469
Score = 68.6 bits (166), Expect = 1e-11
Identities = 60/244 (24%), Positives = 113/244 (46%), Gaps = 32/244 (13%)
Query: 163 ASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSP---------DGKYVVSGFDVDHGIC 212
A Y K ++ D+ET + W+ R+ + C+ D + +VSG D+ I
Sbjct: 270 ALYPKIIQ--DIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLR-DNTIK 326
Query: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
I D + ++ H T S+ C D + + + S D +++WDV + L T+ H
Sbjct: 327 IWDKNTLECKRILTGH-TGSVL--CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-H 382
Query: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQ---GHEGSVSSCHF 329
A+ + F+ + T S D+++ +W++ + +TL + GH +V+ F
Sbjct: 383 CEAVLH--LRFNNGMMVTCSKDRSIAVWDMASP------TDITLRRVLVGHRAAVNVVDF 434
Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
D +++S DRT+ +W+ + +L GH + + + ++S S D T+RL
Sbjct: 435 --DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRL 490
Query: 390 WNIE 393
W+IE
Sbjct: 491 WDIE 494
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 91.3 bits (225), Expect = 2e-18
Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)
Query: 56 ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
AT+ P A+ ++ PP H + H P ++ + P +K +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178
Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
E V C + L SGS D T ++W+ + S +R+ H + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
D + + SYD R W E G L + ++ I + K++ G YV+S V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296
Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
D I DA H ++ D D Q AS S D CI + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
+ T + H+N ++ + SG L + S D LKIW++ ACV +Q H +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404
Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
+ ++ S L S FD TV +WDV +G +L H + V VA S +
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 376 KWILSASKDRTMRLWNIE 393
K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 78.6 bits (192), Expect = 1e-14
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
D T L GSYD ++W +H K P+ + V++A DKT W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D TG+ + + + + + + + D+ +C + ++ HT
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
+ + +DP +AS S D +KIW + A + + +AHS I ++ +G
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419
Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
L ++S+D +++W+V G C + H+ V S F+ D +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Query: 343 RTVAIWDVAEGYRKLSLKG 361
+ V IW+ G S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492
Score = 53.5 bits (127), Expect = 4e-07
Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)
Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
+ +TS ++ D +A S D +IW T L + H I + G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
+ DK IW+ HTGE + C V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
QGH V++ + L S D T+ IW + + L+ H+ + + S
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
N+ + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441
Score = 32.3 bits (72), Expect = 0.96
Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L H+ V + F D L SGS+D V +W+ GS+V ++ + E
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505
Query: 158 SRVIAASYDKTVRAWDL 174
+V A++ D +V DL
Sbjct: 506 DKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 91.3 bits (225), Expect = 2e-18
Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)
Query: 56 ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
AT+ P A+ ++ PP H + H P ++ + P +K +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178
Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
E V C + L SGS D T ++W+ + S +R+ H + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
D + + SYD R W E G L + ++ I + K++ G YV+S V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296
Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
D I DA H ++ D D Q AS S D CI + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
+ T + H+N ++ + SG L + S D LKIW++ ACV +Q H +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404
Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
+ ++ S L S FD TV +WDV +G +L H + V VA S +
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 376 KWILSASKDRTMRLWNIE 393
K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 78.6 bits (192), Expect = 1e-14
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
D T L GSYD ++W +H K P+ + V++A DKT W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D TG+ + + + + + + + D+ +C + ++ HT
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
+ + +DP +AS S D +KIW + A + + +AHS I ++ +G
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419
Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
L ++S+D +++W+V G C + H+ V S F+ D +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Query: 343 RTVAIWDVAEGYRKLSLKG 361
+ V IW+ G S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492
Score = 53.5 bits (127), Expect = 4e-07
Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)
Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
+ +TS ++ D +A S D +IW T L + H I + G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
+ DK IW+ HTGE + C V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
QGH V++ + L S D T+ IW + + L+ H+ + + S
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
N+ + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441
Score = 32.3 bits (72), Expect = 0.96
Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L H+ V + F D L SGS+D V +W+ GS+V ++ + E
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505
Query: 158 SRVIAASYDKTVRAWDL 174
+V A++ D +V DL
Sbjct: 506 DKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 91.3 bits (225), Expect = 2e-18
Identities = 98/378 (25%), Positives = 154/378 (40%), Gaps = 57/378 (15%)
Query: 56 ATLDPLALDREPPP--------------HLLPEKHQVPEKLIWGDQDPLSKIPFKILSGH 101
AT+ P A+ ++ PP H + H P ++ + P +K +L GH
Sbjct: 122 ATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKAT--VLRGH 178
Query: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGS-----------VVRDFEHRPKA--PV 148
E V C + L SGS D T ++W+ + S +R+ H + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDV 207
D + + SYD R W E G L + ++ I + K++ G YV+S V
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSA-GV 296
Query: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQR---VASVSLDRCIKIWDVTSQAT 264
D I DA H ++ D D Q AS S D CI + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPAL-----DVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
+ T + H+N ++ + SG L + S D LKIW++ ACV +Q H +
Sbjct: 352 VKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD------ACVHDLQAHSKEI 404
Query: 325 SSCHFA---------RDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
+ ++ S L S FD TV +WDV +G +L H + V VA S +
Sbjct: 405 YTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG 464
Query: 376 KWILSASKDRTMRLWNIE 393
K++ S S D+ + +WN +
Sbjct: 465 KYLASGSFDKYVHIWNTQ 482
Score = 78.6 bits (192), Expect = 1e-14
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 22/259 (8%)
Query: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
D T L GSYD ++W +H K P+ + V++A DKT W
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 173 DLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTR 231
D TG+ + + + + + + + D+ +C + ++ HT
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF---QGHTN 360
Query: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH----- 286
+ + +DP +AS S D +KIW + A + + +AHS I ++ +G
Sbjct: 361 EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL-QAHSKEIYTIKWSPTGPATSNP 419
Query: 287 ----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD 342
L ++S+D +++W+V G C + H+ V S F+ D +L SG FD
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQG------VCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Query: 343 RTVAIWDVAEGYRKLSLKG 361
+ V IW+ G S +G
Sbjct: 474 KYVHIWNTQSGSLVHSYQG 492
Score = 53.5 bits (127), Expect = 4e-07
Identities = 46/208 (22%), Positives = 77/208 (37%), Gaps = 46/208 (22%)
Query: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
+ +TS ++ D +A S D +IW T L + H I + G+++ +
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 291 SSWDKNLKIWNVHTGEFRN-----------------------------------CGACVT 315
+ DK IW+ HTGE + C V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS--- 372
QGH V++ + L S D T+ IW + + L+ H+ + + S
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 373 ------NNKKWILSASKDRTMRLWNIEE 394
N+ + SAS D T+RLW++E+
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQ 441
Score = 32.3 bits (72), Expect = 0.96
Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
L H+ V + F D L SGS+D V +W+ GS+V ++ + E
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ--GTGGIFEVCWNARG 505
Query: 158 SRVIAASYDKTVRAWDL 174
+V A++ D +V DL
Sbjct: 506 DKVGASASDGSVCVLDL 522
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 90.9 bits (224), Expect = 2e-18
Identities = 80/313 (25%), Positives = 142/313 (45%), Gaps = 18/313 (5%)
Query: 87 QDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWD-PVDGSVVRDFEHRPK 145
+DP+ + FK GH+ A+++ + +L + S+D + LW+ R H+
Sbjct: 6 EDPVLERYFK---GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62
Query: 146 APVVECSITGDSSRVIAASYDKTVRAWDLET-GKLLWKVRYDTFIVSCKFSPDGKYVVSG 204
V+ S G+ + +AS D+TVR W + GK + + S FS DG+++ +
Sbjct: 63 VTSVQFSPHGNL--LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
Query: 205 FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQAT 264
+ D I + + + HT + F PD + + S S D+ IKIWD T++
Sbjct: 121 SE-DKSIKVWSMYRQRFLYSLY-RHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
+ + + A + F SG + ++ D+ +K+W+V + + Q H G V
Sbjct: 179 VNNFSDSVGFA-NFVDFNPSGTCIASAGSDQTVKVWDVRVNKL------LQHYQVHSGGV 231
Query: 325 SSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKD 384
+ F ++LI+ D T+ I D+ EG +L+GH V V+ S + S D
Sbjct: 232 NCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
Query: 385 RTMRLW--NIEEI 395
+ LW N +E+
Sbjct: 292 TQVLLWRTNFDEL 304
Score = 59.7 bits (143), Expect = 6e-09
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 10/135 (7%)
Query: 260 TSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNV--HTGEFRNCGACVTLM 317
T L K H AI++ + +G L T+SWD L +WN H +R G
Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG------ 58
Query: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
H+ V+S F+ + L S DRTV +W + + K H V V S + ++
Sbjct: 59 --HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
Query: 378 ILSASKDRTMRLWNI 392
+ +AS+D+++++W++
Sbjct: 117 LATASEDKSIKVWSM 131
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 90.1 bits (222), Expect = 4e-18
Identities = 66/244 (27%), Positives = 115/244 (47%), Gaps = 22/244 (9%)
Query: 160 VIAASYDKTVRAWDLETGKLLWKVR------YDTFIVSCKFSPDGKYVVSGFDVDHGICI 213
+++AS DKT+ W L + + + + F+ S DG++ +SG D + +
Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSG-SWDGTLRL 89
Query: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
D TT H T+ + S F D++++ S S D+ IK+W+ ++HS
Sbjct: 90 WDLTTGTTTRRFVGH-TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148
Query: 274 NAISNCCFTFSGH----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHF 329
+S C FS + + + WDK +K+WN+ NC T GH G +++
Sbjct: 149 EWVS--CVRFSPNSSNPIIVSCGWDKLVKVWNL-----ANC-KLKTNHIGHTGYLNTVTV 200
Query: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
+ D S SGG D +WD+ EG +L G D + + S N+ W L A+ ++++
Sbjct: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYW-LCAATGPSIKI 258
Query: 390 WNIE 393
W++E
Sbjct: 259 WDLE 262
Score = 85.1 bits (209), Expect = 1e-16
Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 21/274 (7%)
Query: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECS 152
IP + L GH H VS D LSGS+D T++LWD G+ R F K V+ +
Sbjct: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVA 112
Query: 153 ITGDSSRVIAASYDKTVRAWD-LETGKLLWKVRYDTFIVSC-KFSPDGK---YVVSGFDV 207
+ D+ ++++ S DKT++ W+ L K + + VSC +FSP+ V G+D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 208 DHGICIMDAENITTVSVIKDH--HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
++ N+ + +H HT + + PD AS D +WD+ L
Sbjct: 173 -----LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
Query: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVH----TGEFRNCGACVTLMQGHE 321
T+ + I+ CF+ + ++LC ++ ++KIW++ E + T +
Sbjct: 228 YTLD--GGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQ-EVISTSSKAEP 283
Query: 322 GSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYR 355
+S ++ D L +G D V +W V G R
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Score = 72.4 bits (176), Expect = 8e-13
Identities = 41/134 (30%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
Query: 259 VTSQATLLTITKAHSNAISNCCFTFS-GHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLM 317
+T Q TL K H+ ++ T + ++S DK + +W + T + N G +
Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-TRDETNYGIPQRAL 59
Query: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
+GH VS + D F +SG +D T+ +WD+ G GH V+ VA S++ +
Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
Query: 378 ILSASKDRTMRLWN 391
I+S S+D+T++LWN
Sbjct: 120 IVSGSRDKTIKLWN 133
Score = 68.9 bits (167), Expect = 9e-12
Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 12/170 (7%)
Query: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
H+ ++ D Q S S D +++WD+T+ T H+ + + F+ +
Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQI 120
Query: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQ--GHEGSVSSCHFARDSS--FLISGGFDRT 344
+ S DK +K+WN G C +Q H VS F+ +SS ++S G+D+
Sbjct: 121 VSGSRDKTIKLWNT-------LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173
Query: 345 VAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEE 394
V +W++A K + GH ++ V +S + S KD LW++ E
Sbjct: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223
Score = 47.0 bits (110), Expect = 4e-05
Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 6/82 (7%)
Query: 317 MQGHEGSVSSCHFARD-SSFLISGGFDRTVAIWDVAE-----GYRKLSLKGHNDWVMDVA 370
++GH G V+ ++S D+T+ +W + G + +L+GH+ +V DV
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
Query: 371 ISNNKKWILSASKDRTMRLWNI 392
IS++ ++ LS S D T+RLW++
Sbjct: 71 ISSDGQFALSGSWDGTLRLWDL 92
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,701,954
Number of Sequences: 37866
Number of extensions: 940496
Number of successful extensions: 7098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 3504
Number of HSP's gapped (non-prelim): 1572
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.