Search of human proteins with 10190748

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10190748 CEGP1 protein [Homo sapiens]
         (999 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10190748 CEGP1 protein [Homo sapiens]                             2163   0.0  
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]   1395   0.0  
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]    1294   0.0  
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             255   1e-67
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             255   1e-67
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               240   6e-63
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      228   2e-59
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      215   2e-55
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      210   5e-54
gi|46249414 latent transforming growth factor beta binding prote...   194   3e-49
gi|46249412 latent transforming growth factor beta binding prote...   194   3e-49
gi|4557733 latent transforming growth factor beta binding protei...   187   6e-47
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              177   6e-44
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              176   1e-43
gi|110347437 latent transforming growth factor beta binding prot...   175   2e-43
gi|110347412 latent transforming growth factor beta binding prot...   175   2e-43
gi|110347431 latent transforming growth factor beta binding prot...   175   2e-43
gi|118572606 hemicentin 1 [Homo sapiens]                              168   3e-41
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              164   3e-40
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              164   3e-40
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        164   3e-40
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              164   3e-40
gi|194328809 latent transforming growth factor beta binding prot...   157   5e-38
gi|18497288 latent transforming growth factor beta binding prote...   154   4e-37
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   148   2e-35
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   148   2e-35
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   148   2e-35
gi|19743803 fibulin 5 precursor [Homo sapiens]                        142   1e-33
gi|148833508 notch1 preproprotein [Homo sapiens]                      139   1e-32
gi|134244285 Notch homolog 3 [Homo sapiens]                           138   3e-32

>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score = 2163 bits (5605), Expect = 0.0
 Identities = 999/999 (100%), Positives = 999/999 (100%)

Query: 1   MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADA 60
           MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADA
Sbjct: 1   MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADA 60

Query: 61  LCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLA 120
           LCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLA
Sbjct: 61  LCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLA 120

Query: 121 HDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK 180
           HDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
Sbjct: 121 HDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK 180

Query: 181 DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCH 240
           DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCH
Sbjct: 181 DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCH 240

Query: 241 PQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDT 300
           PQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDT
Sbjct: 241 PQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDT 300

Query: 301 STGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEK 360
           STGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEK
Sbjct: 301 STGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEK 360

Query: 361 SCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVN 420
           SCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVN
Sbjct: 361 SCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVN 420

Query: 421 TVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHL 480
           TVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHL
Sbjct: 421 TVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHL 480

Query: 481 SSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQV 540
           SSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQV
Sbjct: 481 SSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQV 540

Query: 541 PGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQ 600
           PGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQ
Sbjct: 541 PGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQ 600

Query: 601 FHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNG 660
           FHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNG
Sbjct: 601 FHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNG 660

Query: 661 TFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQ 720
           TFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQ
Sbjct: 661 TFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQ 720

Query: 721 PEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFG 780
           PEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFG
Sbjct: 721 PEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFG 780

Query: 781 KNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTIN 840
           KNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTIN
Sbjct: 781 KNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTIN 840

Query: 841 PPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLW 900
           PPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLW
Sbjct: 841 PPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLW 900

Query: 901 IQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDV 960
           IQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDV
Sbjct: 901 IQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDV 960

Query: 961 LAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK 999
           LAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
Sbjct: 961 LAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK 999


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score = 1395 bits (3611), Expect = 0.0
 Identities = 647/1012 (63%), Positives = 758/1012 (74%), Gaps = 90/1012 (8%)

Query: 36  RGRAAGPQE-----DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC 90
           RGR AG        DVDEC++G DDCH DA+CQNTP SYKC CKPGY+GEG+QCEDIDEC
Sbjct: 19  RGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDEC 78

Query: 91  GNEL-NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGS 149
            N+  NGGCVH+C+NIPGNYRCTCFDGFMLAHDGHNCLDVDEC +NNGGCQ  CVN MGS
Sbjct: 79  ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGS 138

Query: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKN 209
           YEC C  GFFLSDNQHTCIHRS EG++CMNKDHGC+HIC+E P+G VAC+CRPGF+LA+N
Sbjct: 139 YECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198

Query: 210 QRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS 269
           Q+DC LTCN+GNGGCQHSC+DT  GP C CH +Y +H+DGR+C+E               
Sbjct: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE--------------- 243

Query: 270 VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
                          TCAVNNGGCDRTCKDT+TGV CSCPVGFTLQ DGKTCKDI+EC  
Sbjct: 244 ---------------TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288

Query: 330 RNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACAC 389
            NGGCDHFC+N VGSF+CGC+KG+KLLTDE++CQD+DECS +RTCDH CIN PG+F C C
Sbjct: 289 NNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLC 348

Query: 390 NRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV-KGL 448
           +RGY LYG THCGD +ECS++NG C Q CVNT GSYEC C PG +LHWN KDCVE  K L
Sbjct: 349 HRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCL 408

Query: 449 LPTSVSPRVSLHCGKSGGGDGCFLRC---------------------------------- 474
                SPR  L C K+GG + CFL C                                  
Sbjct: 409 SRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGT 468

Query: 475 HSGIHLS---SDVTTIRTSVTFKLNEGKCSLK---NAELFPEGLRPALPEKHSSVKESFR 528
            SG+  S   +  T I+    FK+ + KC L+    A       +P L   H +      
Sbjct: 469 SSGLGPSCSDAPTTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVT------ 522

Query: 529 YVNLTCSSGKQVPGAPGRPSTPKEM-FITVEFELETNQKEVTASCDLSCIVKRTEKRLRK 587
           +V L C S K+     GR S  KE+  IT EFE+ET  +E + +C+  C+ KR E+ L+ 
Sbjct: 523 FVTLKCDSSKK--RRRGRKSPSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQA 580

Query: 588 AIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYY 647
           AI+TLRK++ R+QF++Q+SG   +VA++P +  E Q  +CG GQ   +++CV+C  GT++
Sbjct: 581 AIKTLRKSIGRQQFYVQVSGTEYEVAQRPAKALEGQG-ACGAGQVLQDSKCVACGPGTHF 639

Query: 648 DGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADG 707
            G   +C+ C  GT+Q+ EGQ++C PCP   +S  L  P A N+SECGG C PG +SADG
Sbjct: 640 GGELGQCVSCMPGTYQDMEGQLSCTPCP---SSDGLGLPGARNVSECGGQCSPGFFSADG 696

Query: 708 FAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRC 767
           F PCQ C +GT+QPE GRT CFPCGGGL TKH+G TSFQDCE +V CSPGH YNTTTHRC
Sbjct: 697 FKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRC 756

Query: 768 IRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPG 827
           IRCPVGTYQPEFG+N+C++CPGNT+TDFDGSTN+T CKN+ CGGELGD+TGYIESPNYPG
Sbjct: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPG 816

Query: 828 NYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYE 887
           +YPAN EC W I PPPKRRILIVVPEIFLPIED+CGD LVMRK++S  S+TTYETCQTYE
Sbjct: 817 DYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYE 876

Query: 888 RPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEI 947
           RPIAFTSRS+KLWIQFKSNEGNS +GFQVPYVTYDEDYQ+LIEDIVRDGRLYASENHQEI
Sbjct: 877 RPIAFTSRSRKLWIQFKSNEGNSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEI 936

Query: 948 LKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK 999
           LKDKKLIKALFDVLAHPQNYFKYTAQES+EMFPRSFI+LLRSKVSRFLRPYK
Sbjct: 937 LKDKKLIKALFDVLAHPQNYFKYTAQESKEMFPRSFIKLLRSKVSRFLRPYK 988


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 596/1022 (58%), Positives = 732/1022 (71%), Gaps = 78/1022 (7%)

Query: 22  LPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEG 81
           +P L LL   V     + +   +DVDEC +G D+CH DA+CQNTP SYKC CK GY G+G
Sbjct: 6   VPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG 65

Query: 82  RQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH 141
           + C+D+DEC  E N GCVHDC+NIPGNYRCTC+DGF LAHDGHNCLDVDEC E NGGCQ 
Sbjct: 66  KHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ 125

Query: 142 TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECR 201
           +CVN+MGSYEC C+EGFFLSDNQHTCI R EEG++CMNK+HGC+HIC+E P+G +ACECR
Sbjct: 126 SCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECR 185

Query: 202 PGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLE 261
           PGFEL KNQRDC LTCN+GNGGCQH+CDDT  GP C CH ++ +HTDG++C+E       
Sbjct: 186 PGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE------- 238

Query: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
                                  TCAVNNGGCD  C D +TGVHC+CPVGF LQ D KTC
Sbjct: 239 -----------------------TCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275

Query: 322 KDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINH 381
           KDIDEC+  NGGCDH C+N VGSF+C CKKG+KLL +E++CQD+DECS DRTCDH C+N 
Sbjct: 276 KDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNT 335

Query: 382 PGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGY-KLHWNKK 440
           PG+F C C+RGY LYG THCGD +ECSIN GGC+  C+NT GSY+C C  G  +LHWN K
Sbjct: 336 PGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGK 395

Query: 441 DCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRC-------------------------- 474
           DC E      +  + +  L C +SG  D C L C                          
Sbjct: 396 DCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAA 455

Query: 475 -----HSGIHLSSD------VTTIRTSVTFKLNEGKCSL--KNAELFPEGLRPALPEKHS 521
                H+G   +S+      V +I+   +FK+ + KC L  +N     E  R   P    
Sbjct: 456 PARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAP 515

Query: 522 SVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMF-ITVEFELETNQKEVTASCDLSCIVKR 580
             +    +++L C S ++  G   R    KE+  +T+E E E   +E TASC L C+ +R
Sbjct: 516 CSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQR 575

Query: 581 TEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAE---SCGVGQGHAENQ 637
            E+RL+ +++ LRK++++++F L+L+G++ ++A KP   +  +AE   SC  GQ  A  +
Sbjct: 576 MERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTK 635

Query: 638 CVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGL 697
           CVSC  GTYY G  E+C+ CP GTFQ  EGQ++C+ CP     G L    A N++ C G 
Sbjct: 636 CVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLG---ATNVTTCAGQ 692

Query: 698 CQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPG 757
           C PG++S DGF PCQ C  GT+QPEAGRT CFPCGGGL TKH+GA SFQDC+T+VQCSPG
Sbjct: 693 CPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPG 752

Query: 758 HFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFT 817
           H+YNT+ HRCIRC +G+YQP+F +N C  CPGNT+TDFDGST++ QCKNR+CGGELG+FT
Sbjct: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFT 812

Query: 818 GYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSV 877
           GYIESPNYPGNYPA  EC W INPPPKR+ILIVVPEIFLP ED+CGD LVMRK SS +S+
Sbjct: 813 GYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSI 872

Query: 878 TTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGR 937
           TTYETCQTYERPIAFT+RS+KLWI FK++E NSARGFQ+PYVTYDEDY++L+EDIVRDGR
Sbjct: 873 TTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGR 932

Query: 938 LYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRP 997
           LYASENHQEILKDKKLIKA F+VLAHPQNYFKYT ++ +EM P+SFI+LLRSKVS FLRP
Sbjct: 933 LYASENHQEILKDKKLIKAFFEVLAHPQNYFKYT-EKHKEMLPKSFIKLLRSKVSSFLRP 991

Query: 998 YK 999
           YK
Sbjct: 992 YK 993


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  255 bits (652), Expect = 1e-67
 Identities = 133/388 (34%), Positives = 189/388 (48%), Gaps = 42/388 (10%)

Query: 62  CQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML 119
           C N P SY C CK GY    +   C   D C  E +  C   C+N+PG++ C C+ G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME-DHNCEQLCVNVPGSFVCQCYSGYAL 311

Query: 120 AHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179
           A DG  C+ VD C   N GC+H CVN  GSY C C EGF L+ ++ TC         C +
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367

Query: 180 KDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPEC 237
            +HGC H C      S +C C  GF L  +++ C  I  C     GC+H C +  +   C
Sbjct: 368 SNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426

Query: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
            CH  Y +  +G++C                              ++ CA  + GC++ C
Sbjct: 427 RCHRGYTLDPNGKTCSR----------------------------VDHCAQQDHGCEQLC 458

Query: 298 KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLT 357
            +T     C C  GF +  D KTC  +D C   + GC++ C N+  SF C C +G  L +
Sbjct: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518

Query: 358 DEKSCQDVDECSL-DRTCDHSCINHPGTFACACNRGYTLY--GFTHCGDTNECSINNGGC 414
           D K+C  +D C+L D  C+HSC++   +F C C  GY L   G T C   + C   + GC
Sbjct: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT-CRRKDVCQAIDHGC 577

Query: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
           + +CVN+  SY C+C  G++L  + K C
Sbjct: 578 EHICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score =  235 bits (600), Expect = 1e-61
 Identities = 122/354 (34%), Positives = 175/354 (49%), Gaps = 39/354 (11%)

Query: 94  LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC 153
           L   C H C+NIPG+Y C C  G++L  D   C   D C   +  C+  CVNV GS+ C 
Sbjct: 245 LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ 304

Query: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
           C  G+ L+++   C+        C +++HGC H C  A  GS  C+C  GF L  +++ C
Sbjct: 305 CYSGYALAEDGKRCVAVD----YCASENHGCEHECVNAD-GSYLCQCHEGFALNPDKKTC 359

Query: 214 --ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
             I  C   N GCQH C +T D   C C   + ++ D ++C                   
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC------------------- 400

Query: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331
                  RR+    CA+N  GC+  C +     +C C  G+TL  +GKTC  +D C  ++
Sbjct: 401 -------RRI--NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451

Query: 332 GGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL-DRTCDHSCINHPGTFACACN 390
            GC+  C N   SF C C +GF +  D K+C  VD C L D  C++SC+N   +FAC C 
Sbjct: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511

Query: 391 RGYTLY--GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
            G+ L   G T C   + C++ + GC+  CV++  S+ CQC  GY L  + K C
Sbjct: 512 EGHVLRSDGKT-CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564



 Score =  195 bits (496), Expect = 2e-49
 Identities = 112/381 (29%), Positives = 170/381 (44%), Gaps = 62/381 (16%)

Query: 47  DECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDCLN 104
           D CA  ++D + + LC N P S+ C C  GY    +G++C  +D C +E N GC H+C+N
Sbjct: 281 DLCA--MEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337

Query: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN- 163
             G+Y C C +GF L  D   C  +D C  +N GCQH CVN   SY C C +GF L+ + 
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397

Query: 164 ----------------QHTCIHRSEEGLS--------------------CMNKDHGCSHI 187
                           +H C++  E                        C  +DHGC  +
Sbjct: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457

Query: 188 CKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKM 245
           C      S  C+C  GF + ++ + C  +  C   + GC++SC +      C C   + +
Sbjct: 458 CLNT-EDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516

Query: 246 HTDGRSCLEREDTVL--EVTESNTTSVVDG-------------DKRVKRRLLMETCAVNN 290
            +DG++C + +   L     E +  S  D              D +  RR   + C   +
Sbjct: 517 RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR--KDVCQAID 574

Query: 291 GGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCK 350
            GC+  C ++     C C  GF L  DGK C+  D C++ + GC+H C N   S+ C C 
Sbjct: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCS 634

Query: 351 KGFKLLTDEKSCQDVDECSLD 371
           +GF L  D + C+   E  +D
Sbjct: 635 EGFVLAEDGRRCKKCTEGPID 655



 Score =  173 bits (439), Expect = 6e-43
 Identities = 88/274 (32%), Positives = 131/274 (47%), Gaps = 35/274 (12%)

Query: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL--TCNHGNGGCQHSCDDTADG 234
           C   +H C+H C   P GS  C C+ G+ L  +Q  C +   C   +  C+  C +    
Sbjct: 242 CSTLEHNCAHFCINIP-GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
             C C+  Y +  DG+ C                            + ++ CA  N GC+
Sbjct: 301 FVCQCYSGYALAEDGKRC----------------------------VAVDYCASENHGCE 332

Query: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFK 354
             C +      C C  GF L  D KTC  ID C + N GC H C N   S+ C C KGF 
Sbjct: 333 HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFT 392

Query: 355 LLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINN 411
           L  D+K+C+ ++ C+L++  C+H C+N   ++ C C+RGYTL   G T C   + C+  +
Sbjct: 393 LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKT-CSRVDHCAQQD 451

Query: 412 GGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            GC+Q+C+NT  S+ CQC  G+ ++ + K C  V
Sbjct: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485



 Score =  119 bits (299), Expect = 1e-26
 Identities = 68/218 (31%), Positives = 94/218 (43%), Gaps = 20/218 (9%)

Query: 278 KRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF 337
           K+      C+     C   C +      C C  G+ L  D  TC+  D C   +  C+  
Sbjct: 234 KKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293

Query: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTLY 396
           C N+ GSF C C  G+ L  D K C  VD C S +  C+H C+N  G++ C C+ G+ L 
Sbjct: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 397 -GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK-------GL 448
                C   + C+ +N GCQ  CVNT  SY C C  G+ L+ +KK C  +        G 
Sbjct: 354 PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 449 LPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTT 486
               V+   S +C           RCH G  L  +  T
Sbjct: 414 EHECVNMEESYYC-----------RCHRGYTLDPNGKT 440


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  255 bits (652), Expect = 1e-67
 Identities = 133/388 (34%), Positives = 189/388 (48%), Gaps = 42/388 (10%)

Query: 62  CQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML 119
           C N P SY C CK GY    +   C   D C  E +  C   C+N+PG++ C C+ G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME-DHNCEQLCVNVPGSFVCQCYSGYAL 311

Query: 120 AHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179
           A DG  C+ VD C   N GC+H CVN  GSY C C EGF L+ ++ TC         C +
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367

Query: 180 KDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPEC 237
            +HGC H C      S +C C  GF L  +++ C  I  C     GC+H C +  +   C
Sbjct: 368 SNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426

Query: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
            CH  Y +  +G++C                              ++ CA  + GC++ C
Sbjct: 427 RCHRGYTLDPNGKTCSR----------------------------VDHCAQQDHGCEQLC 458

Query: 298 KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLT 357
            +T     C C  GF +  D KTC  +D C   + GC++ C N+  SF C C +G  L +
Sbjct: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518

Query: 358 DEKSCQDVDECSL-DRTCDHSCINHPGTFACACNRGYTLY--GFTHCGDTNECSINNGGC 414
           D K+C  +D C+L D  C+HSC++   +F C C  GY L   G T C   + C   + GC
Sbjct: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT-CRRKDVCQAIDHGC 577

Query: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
           + +CVN+  SY C+C  G++L  + K C
Sbjct: 578 EHICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score =  235 bits (600), Expect = 1e-61
 Identities = 122/354 (34%), Positives = 175/354 (49%), Gaps = 39/354 (11%)

Query: 94  LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC 153
           L   C H C+NIPG+Y C C  G++L  D   C   D C   +  C+  CVNV GS+ C 
Sbjct: 245 LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ 304

Query: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
           C  G+ L+++   C+        C +++HGC H C  A  GS  C+C  GF L  +++ C
Sbjct: 305 CYSGYALAEDGKRCVAVD----YCASENHGCEHECVNAD-GSYLCQCHEGFALNPDKKTC 359

Query: 214 --ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
             I  C   N GCQH C +T D   C C   + ++ D ++C                   
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC------------------- 400

Query: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331
                  RR+    CA+N  GC+  C +     +C C  G+TL  +GKTC  +D C  ++
Sbjct: 401 -------RRI--NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451

Query: 332 GGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL-DRTCDHSCINHPGTFACACN 390
            GC+  C N   SF C C +GF +  D K+C  VD C L D  C++SC+N   +FAC C 
Sbjct: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511

Query: 391 RGYTLY--GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
            G+ L   G T C   + C++ + GC+  CV++  S+ CQC  GY L  + K C
Sbjct: 512 EGHVLRSDGKT-CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564



 Score =  195 bits (496), Expect = 2e-49
 Identities = 112/381 (29%), Positives = 170/381 (44%), Gaps = 62/381 (16%)

Query: 47  DECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDCLN 104
           D CA  ++D + + LC N P S+ C C  GY    +G++C  +D C +E N GC H+C+N
Sbjct: 281 DLCA--MEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337

Query: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN- 163
             G+Y C C +GF L  D   C  +D C  +N GCQH CVN   SY C C +GF L+ + 
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397

Query: 164 ----------------QHTCIHRSEEGLS--------------------CMNKDHGCSHI 187
                           +H C++  E                        C  +DHGC  +
Sbjct: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457

Query: 188 CKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKM 245
           C      S  C+C  GF + ++ + C  +  C   + GC++SC +      C C   + +
Sbjct: 458 CLNT-EDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516

Query: 246 HTDGRSCLEREDTVL--EVTESNTTSVVDG-------------DKRVKRRLLMETCAVNN 290
            +DG++C + +   L     E +  S  D              D +  RR   + C   +
Sbjct: 517 RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR--KDVCQAID 574

Query: 291 GGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCK 350
            GC+  C ++     C C  GF L  DGK C+  D C++ + GC+H C N   S+ C C 
Sbjct: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCS 634

Query: 351 KGFKLLTDEKSCQDVDECSLD 371
           +GF L  D + C+   E  +D
Sbjct: 635 EGFVLAEDGRRCKKCTEGPID 655



 Score =  173 bits (439), Expect = 6e-43
 Identities = 88/274 (32%), Positives = 131/274 (47%), Gaps = 35/274 (12%)

Query: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL--TCNHGNGGCQHSCDDTADG 234
           C   +H C+H C   P GS  C C+ G+ L  +Q  C +   C   +  C+  C +    
Sbjct: 242 CSTLEHNCAHFCINIP-GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
             C C+  Y +  DG+ C                            + ++ CA  N GC+
Sbjct: 301 FVCQCYSGYALAEDGKRC----------------------------VAVDYCASENHGCE 332

Query: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFK 354
             C +      C C  GF L  D KTC  ID C + N GC H C N   S+ C C KGF 
Sbjct: 333 HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFT 392

Query: 355 LLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINN 411
           L  D+K+C+ ++ C+L++  C+H C+N   ++ C C+RGYTL   G T C   + C+  +
Sbjct: 393 LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKT-CSRVDHCAQQD 451

Query: 412 GGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            GC+Q+C+NT  S+ CQC  G+ ++ + K C  V
Sbjct: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485



 Score =  119 bits (299), Expect = 1e-26
 Identities = 68/218 (31%), Positives = 94/218 (43%), Gaps = 20/218 (9%)

Query: 278 KRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF 337
           K+      C+     C   C +      C C  G+ L  D  TC+  D C   +  C+  
Sbjct: 234 KKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293

Query: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTLY 396
           C N+ GSF C C  G+ L  D K C  VD C S +  C+H C+N  G++ C C+ G+ L 
Sbjct: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 397 -GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK-------GL 448
                C   + C+ +N GCQ  CVNT  SY C C  G+ L+ +KK C  +        G 
Sbjct: 354 PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 449 LPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTT 486
               V+   S +C           RCH G  L  +  T
Sbjct: 414 EHECVNMEESYYC-----------RCHRGYTLDPNGKT 440


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  240 bits (612), Expect = 6e-63
 Identities = 131/379 (34%), Positives = 180/379 (47%), Gaps = 56/379 (14%)

Query: 89  ECGNELNGGCVHDCLNIPGNYR-CTCFDGFMLAHDGHNC-LDVDECLENNGGCQHTCVNV 146
           EC   L   C H    +PG+ + C C  GF     G  C  DVDEC  +NGGCQH CVN 
Sbjct: 127 ECSASL---CFHGGRCVPGSAQPCHCPPGFQ----GPRCQYDVDECRTHNGGCQHRCVNT 179

Query: 147 MGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFEL 206
            GSY C CK GF L  +  TC+  +    SC   + GC H C +       C+CRPGF+L
Sbjct: 180 PGSYLCECKPGFRLHTDSRTCLAIN----SCALGNGGCQHHCVQLTITRHRCQCRPGFQL 235

Query: 207 AKNQRDCILT--CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTE 264
            ++ R C+    C + NG C H C        C CH  Y++  DG++C   ED       
Sbjct: 236 QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC---ED------- 285

Query: 265 SNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                             ++ CA     C   C +T     C C  G+ L  DG+ C  I
Sbjct: 286 ------------------VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRI 327

Query: 325 D-----ECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCI 379
           +      C+  NGGC H C +      C C +G++L TD+++C DVD+C+    C   C 
Sbjct: 328 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCT 387

Query: 380 NHPGTFACACNRGYTLYG-FTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWN 438
           N+PG + C C  GY L      C D +EC+ + GGC+  C N  GS++C C  GY+LH +
Sbjct: 388 NNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHED 447

Query: 439 KKDC-------VEVKGLLP 450
           ++ C       V++ G LP
Sbjct: 448 RRGCSPLEEPMVDLDGELP 466



 Score =  223 bits (568), Expect = 7e-58
 Identities = 112/323 (34%), Positives = 163/323 (50%), Gaps = 31/323 (9%)

Query: 71  CSCKPGYQGEGRQCE-DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDV 129
           C C PG+QG   +C+ D+DEC    NGGC H C+N PG+Y C C  GF L  D   CL +
Sbjct: 147 CHCPPGFQGP--RCQYDVDECRTH-NGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAI 203

Query: 130 DECLENNGGCQHTCVNV-MGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHIC 188
           + C   NGGCQH CV + +  + C C+ GF L ++   C+ RS     C N++  C H C
Sbjct: 204 NSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSP----CANRNGSCMHRC 259

Query: 189 KEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMH 246
            +  RG   CEC  G++LA + + C  +  C  G   C H C +T    +C CH  Y++ 
Sbjct: 260 -QVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELG 318

Query: 247 TDGRSCLEREDTVLEVTESNTTSVVDG------------------DKRVKRRLLMETCAV 288
            DGR C   E  ++   E+N      G                  D   +  + ++ CA 
Sbjct: 319 ADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA- 377

Query: 289 NNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCG 348
           ++  C + C +   G  C C  G+ L  DG  C+D+DEC +  GGC+H C N+ GSF C 
Sbjct: 378 DSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCS 437

Query: 349 CKKGFKLLTDEKSCQDVDECSLD 371
           C+ G++L  D + C  ++E  +D
Sbjct: 438 CEAGYRLHEDRRGCSPLEEPMVD 460



 Score =  163 bits (412), Expect = 9e-40
 Identities = 139/547 (25%), Positives = 197/547 (36%), Gaps = 130/547 (23%)

Query: 46  VDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDCL 103
           ++ CA G   C    + Q T T ++C C+PG+Q   +GR C     C N  NG C+H C 
Sbjct: 203 INSCALGNGGCQHHCV-QLTITRHRCQCRPGFQLQEDGRHCVRRSPCANR-NGSCMHRCQ 260

Query: 104 NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN 163
            + G  RC C  G+ LA DG  C DVDEC      C H C+N  GS++C C  G+ L  +
Sbjct: 261 VVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGAD 320

Query: 164 QHTCIHRSEEGL-SCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILT------ 216
              C     E + SC   + GCSH C     G + C C  G+EL  +QR CI        
Sbjct: 321 GRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPL-CTCPRGYELDTDQRTCIDVDDCADS 379

Query: 217 ------------------------------------CNHGNGGCQHSCDDTADGPECSCH 240
                                               C    GGC+H C + A   +CSC 
Sbjct: 380 PCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCE 439

Query: 241 PQYKMHTDGRSCLEREDTVLE-----------------------------VTESNTTSVV 271
             Y++H D R C   E+ +++                             V      + +
Sbjct: 440 AGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAEL 499

Query: 272 DGDKRVKRRLLMETCAVNNGG--CDRTCKDTSTGVHC-------SCPVGFTLQLDGKTCK 322
            G+  +  + +   C  ++ G  C  TC D   G  C        CP G+T  +  +TC 
Sbjct: 500 RGEHTLTEKFV---CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCP 556

Query: 323 DID-------ECQTRNGGCDHFCKNIVGSFDC-----------GCKKGFKLLTDEKSCQD 364
                      C  +NGG    C ++ G+  C           GC KG+      K C+ 
Sbjct: 557 PDTFGKNCSFSCSCQNGGT---CDSVTGACRCPPGVSGTNCEDGCPKGYY----GKHCRK 609

Query: 365 VDECSLDRTCDH---SCINHPGTFACACNRGYTLYGF-THCGD--------TNECSINNG 412
              C+    C     +C+  PG +   C+     + F   C +        T  C   +G
Sbjct: 610 KCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDG 669

Query: 413 GCQQVCVNTVGSYECQ--CHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C   C        CQ  C  GY      + C    G+   SVS      C     G+ C
Sbjct: 670 SCS--CKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC 727

Query: 471 FLRCHSG 477
              C  G
Sbjct: 728 GQECPVG 734



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 136/555 (24%), Positives = 178/555 (32%), Gaps = 172/555 (30%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNG----- 96
           EDVDECA     C     C N   S++CSC+ GY+   + R C  ++E   +L+G     
Sbjct: 411 EDVDECASSRGGCEHH--CTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFV 468

Query: 97  ----------------------GCVHDCLNIPGNYRCTCFDGFMLAHD--GHNC-LDVDE 131
                                 G   +   + G +  T  + F+   D  GH+C L  D+
Sbjct: 469 RPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLT--EKFVCLDDSFGHDCSLTCDD 526

Query: 132 CLENNGG-------------------CQHTCV-NVMG---SYECCCKEGFFLSDNQHTCI 168
           C   NGG                   C  TC  +  G   S+ C C+ G         C 
Sbjct: 527 C--RNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGAC- 583

Query: 169 HRSEEGLSCMNKDHGC------SHI---CKEAPRGSV-----ACECRPGFELAKNQRDCI 214
            R   G+S  N + GC       H    C  A RG       AC C PG       R C 
Sbjct: 584 -RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLY----GRFCH 638

Query: 215 LTCNHG--NGGCQHSCD---------DTADGPECSCHPQYK---------MHTDGRSCLE 254
           LTC       GC   C          D  DG  CSC   ++         +   G  C +
Sbjct: 639 LTCPPWAFGPGCSEECQCVQPHTQSCDKRDG-SCSCKAGFRGERCQAECELGYFGPGCWQ 697

Query: 255 REDTVLEVTESNTTSVVDGDKRVKRRLLMETCA----VNNGG--CDRTCKDTSTGVH--- 305
                + V   + +   +  KR       E C     V   G  C  +C       H   
Sbjct: 698 ACTCPVGVACDSVSG--ECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVT 755

Query: 306 --CSCPVGFTLQLDGKTCK-DIDE------CQTRNGGCDHFCKNIVGSFDCGCKKGFKLL 356
             C CP G T    G+ C+ D  E      CQ     C H  +    +  C C  GF   
Sbjct: 756 GQCRCPPGRT----GEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFV-- 809

Query: 357 TDEKSCQDV-------DECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNE--- 406
                CQDV         C    +C +    HP T  C+C  G+T +      DT     
Sbjct: 810 --GSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGP 867

Query: 407 -------CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSL 459
                  CS  +G C  +      S  C C  GY                   V PR   
Sbjct: 868 DCSHPCNCSAGHGSCDAI------SGLCLCEAGY-------------------VGPRCEQ 902

Query: 460 HCGKSGGGDGCFLRC 474
            C +   G GC  RC
Sbjct: 903 QCPQGHFGPGCEQRC 917



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 113/457 (24%), Positives = 150/457 (32%), Gaps = 108/457 (23%)

Query: 56   CHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFD 115
            C  D  C   P +  CSC PG+   G  C+   + G+     C H C    G+  C    
Sbjct: 832  CANDGHCH--PATGHCSCAPGW--TGFSCQRACDTGH-WGPDCSHPCNCSAGHGSCDAIS 886

Query: 116  GFMLAHDGH---NCLDVDECLENNGG--------CQH--TCVNVMGSYEC---------- 152
            G  L   G+    C    +C + + G        CQH   C +V G+  C          
Sbjct: 887  GLCLCEAGYVGPRC--EQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCE 944

Query: 153  -CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQR 211
              C  GFF  D +  C      G +C   +  C  +C    RG    E  P      N  
Sbjct: 945  HACPAGFFGLDCRSAC--NCTAGAACDAVNGSC--LCPAGRRGPRCAETCPAHTYGHN-- 998

Query: 212  DCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
             C   C   NG    SCD      +C C P +     G SCL+              + +
Sbjct: 999  -CSQACACFNGA---SCDPVHG--QCHCAPGWM----GPSCLQA-----------CPAGL 1037

Query: 272  DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC--KDIDECQT 329
             GD          +C   NGG   TC   S   HC+CP G+      K C  +D+     
Sbjct: 1038 YGDN------CRHSCLCQNGG---TCDPVSG--HCACPEGWAGLACEKECLPRDVRAGCR 1086

Query: 330  RNGGC--DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDV-------DECSLDRTCDHSCIN 380
             +GGC     C    G   C C  G+   T +K CQ         + C+   +C      
Sbjct: 1087 HSGGCLNGGLCDPHTGR--CLCPAGW---TGDK-CQSPCLRGWFGEACAQRCSCPPGAAC 1140

Query: 381  HPGTFACACNRGYTLYGFTH----------CGDTNECSINNGGCQQVCVNTVGSYECQCH 430
            H  T AC C  G+T  G             C    +C   N  C         +  C C 
Sbjct: 1141 HHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHP------ATGTCSCA 1194

Query: 431  PGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGG 467
             GY     ++ C       P    P     CG   GG
Sbjct: 1195 AGYHGPSCQQRCP------PGRYGPGCEQLCGCLNGG 1225



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 128/497 (25%), Positives = 154/497 (30%), Gaps = 122/497 (24%)

Query: 49   CAQGL--DDCHADALCQN----TPTSYKCSCKPGYQGEG--RQCEDID-ECGNELNGGCV 99
            C  GL  D+C    LCQN     P S  C+C  G+ G    ++C   D   G   +GGC+
Sbjct: 1033 CPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCL 1092

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLD--VDECLENNGGCQH--TCVNVMGSYEC--- 152
            +  L  P   RC C  G+        CL     E       C     C +V G+  C   
Sbjct: 1093 NGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPG 1152

Query: 153  --------CCKEGFFLSDNQHTC--------IHRSEEGLSCMNKDHG------------- 183
                     C  G F  D    C         H +    SC    HG             
Sbjct: 1153 FTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYG 1212

Query: 184  --CSHICKEAPRGSV-----ACECRPGFELAKNQRDCILTCNHGNGG--CQHSCD----- 229
              C  +C     GS      AC C  GF       DC LTC  G  G  C H C      
Sbjct: 1213 PGCEQLCGCLNGGSCDAATGACRCPTGFL----GTDCNLTCPQGRFGPNCTHVCGCGQGA 1268

Query: 230  --DTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCA 287
              D   G  C C P        R C +       V   +T S  +G            C 
Sbjct: 1269 ACDPVTGT-CLCPPGRAGVRCERGCPQNR---FGVGCEHTCSCRNGG----------LCH 1314

Query: 288  VNNGGCDRTCKDTSTGVHC--SCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSF 345
             +NG C  +C    TG HC  +CP G      G  C    EC   N      C+   G+ 
Sbjct: 1315 ASNGSC--SCGLGWTGRHCELACPPGRY----GAACHL--ECSCHNNST---CEPATGTC 1363

Query: 346  DCG-----------CKKGFKLLTDEKSCQDVDECSLDRTCDH---SCINHPGTFACACNR 391
             CG           C  GF        CQ +  C     CD     C+   G     C R
Sbjct: 1364 RCGPGFYGQACEHPCPPGFH----GAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCER 1419

Query: 392  GYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPT 451
            G     F   G    C  + G     C    G   C C PG        DC   +     
Sbjct: 1420 GCEPGSFGE-GCHQRCDCDGGA---PCDPVTGL--CLCPPGRSGATCNLDCRRGQ----- 1468

Query: 452  SVSPRVSLHCGKSGGGD 468
               P  +LHC   GG D
Sbjct: 1469 -FGPSCTLHCDCGGGAD 1484



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 98/411 (23%), Positives = 131/411 (31%), Gaps = 87/411 (21%)

Query: 71   CSCKPGYQGEGRQCEDIDECGNELNGGCVHDCL--------NIPGNYRCTCFDGFMLAHD 122
            CSCK G++GE  +C+   E G     GC   C         ++ G     C  GF     
Sbjct: 671  CSCKAGFRGE--RCQAECELG-YFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC 727

Query: 123  GHNCLDVDECLENNGGCQ---HTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179
            G  C      +  +  C      C  V G  +C C  G    D +  C      GL C  
Sbjct: 728  GQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCEADC-PEGRWGLGCQE 784

Query: 180  KDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADG----- 234
                C H  +  P  + AC C PGF  ++ Q  C          CQ  C    DG     
Sbjct: 785  ICPACQHAARCDPE-TGACLCLPGFVGSRCQDVC--PAGWYGPSCQTRCSCANDGHCHPA 841

Query: 235  -PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC 293
               CSC P +     G SC    DT     + +                   C+  +G C
Sbjct: 842  TGHCSCAPGW----TGFSCQRACDTGHWGPDCSHPC---------------NCSAGHGSC 882

Query: 294  DR-----TCKDTSTGVHC--SCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFD 346
            D       C+    G  C   CP G      G  C+   +CQ     CDH       S  
Sbjct: 883  DAISGLCLCEAGYVGPRCEQQCPQGHF----GPGCEQRCQCQ-HGAACDHV------SGA 931

Query: 347  CGCKKGFKLLTDEKS---------CQDVDECSLDRTCD---HSCINHPGTFACACNRGYT 394
            C C  G++    E +         C+    C+    CD    SC+   G     C     
Sbjct: 932  CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCP 991

Query: 395  LYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444
             + + H C     C  N   C  V        +C C PG    W    C++
Sbjct: 992  AHTYGHNCSQACAC-FNGASCDPV------HGQCHCAPG----WMGPSCLQ 1031



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 186/860 (21%), Positives = 254/860 (29%), Gaps = 190/860 (22%)

Query: 48   ECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE-----------GRQCEDIDECGNELNG 96
            +C+   DDC     C        C C  G+ G            G+ C     C N   G
Sbjct: 519  DCSLTCDDCRNGGTCLLGLDG--CDCPEGWTGLICNETCPPDTFGKNCSFSCSCQN---G 573

Query: 97   GCVHDCLNIPGNYRC-------TCFDGFMLAHDGHNCLDVDECLENNGGCQH---TCVNV 146
            G    C ++ G  RC        C DG    + G +C     C  N G C      C+  
Sbjct: 574  GT---CDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCA-NRGRCHRLYGACLCD 629

Query: 147  MGSY----ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGS-VACECR 201
             G Y       C    F       C        SC  +D  CS  CK   RG     EC 
Sbjct: 630  PGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCS--CKAGFRGERCQAECE 687

Query: 202  PGFELAKNQRDCI----LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED 257
             G+      + C     + C+  +G C   C     G +C    +  + T G +C     
Sbjct: 688  LGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCG--QECPVGTFGVNC----- 740

Query: 258  TVLEVTESNTTSV-------VDGDKRVKRRLLMETCAVN------NGGCDRTCKDTSTGV 304
                   S++ S        V G  R       E C  +        GC   C       
Sbjct: 741  -------SSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAA 793

Query: 305  HCSCPVGFTLQLDG---KTCKDI-------DECQTR-NGGCDHFCKNIVGSFDCGCKKGF 353
             C    G  L L G     C+D+         CQTR +   D  C    G   C C  G+
Sbjct: 794  RCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGH--CSCAPGW 851

Query: 354  KLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNG- 412
               + +++C   D       C H C    G  +C    G  L    + G   E     G 
Sbjct: 852  TGFSCQRAC---DTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGH 908

Query: 413  ---GCQQVCVNTVG------SYECQCHPGYKLHWNKK---------DCVEVKGLLPTSVS 454
               GC+Q C    G      S  C C  G++  + +          DC         +  
Sbjct: 909  FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC 968

Query: 455  PRVSLHCGKSGG--GDGCFLRC--HSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPE 510
              V+  C    G  G  C   C  H+  H  S         +     G+C      + P 
Sbjct: 969  DAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPS 1028

Query: 511  GLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTA 570
             L+      +    ++ R+  L C +G       G  + P E +  +  E E   ++V A
Sbjct: 1029 CLQACPAGLYG---DNCRHSCL-CQNGGTCDPVSGHCACP-EGWAGLACEKECLPRDVRA 1083

Query: 571  SCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVG 630
             C                               + SG  L+     P T       C   
Sbjct: 1084 GC-------------------------------RHSGGCLNGGLCDPHTGR-----CLCP 1107

Query: 631  QGHAENQCVS-CRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAW 689
             G   ++C S C  G + +   +RC  CP G          C        +GA + P  +
Sbjct: 1108 AGWTGDKCQSPCLRGWFGEACAQRCS-CPPGA--------ACHHV-----TGACRCPPGF 1153

Query: 690  NMSECGGLCQPGEYSADGFAPCQLCALG-TFQPEAGRTSCFPCGGGLATKHQGATSFQ-- 746
              S C   C PG +  D    CQ         P  G  SC       A  + G +  Q  
Sbjct: 1154 TGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSC-------AAGYHGPSCQQRC 1206

Query: 747  -------DCETRVQCSPGHFYNTTTHRCIRCPVGTY---------QPEFGKNNCVSCPGN 790
                    CE    C  G   +  T  C RCP G           Q  FG N    C   
Sbjct: 1207 PPGRYGPGCEQLCGCLNGGSCDAATGAC-RCPTGFLGTDCNLTCPQGRFGPNCTHVCGCG 1265

Query: 791  TTTDFDGSTNITQCKNRRCG 810
                 D  T    C   R G
Sbjct: 1266 QGAACDPVTGTCLCPPGRAG 1285



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/167 (26%), Positives = 59/167 (35%), Gaps = 16/167 (9%)

Query: 627  CGVGQGHAENQCVSCRAGTYYDGARERCILCPNGTFQNEEG---QMTCEPCPRPG----N 679
            CG GQG A +       GT         + C  G  QN  G   + TC  C   G    +
Sbjct: 1262 CGCGQGAACDPVT----GTCLCPPGRAGVRCERGCPQNRFGVGCEHTCS-CRNGGLCHAS 1316

Query: 680  SGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKH 739
            +G+      W    C   C PG Y A     C      T +P  G   C P   G A +H
Sbjct: 1317 NGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEH 1376

Query: 740  QGATSFQ--DCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNC 784
                 F    C+    C  G   +  + RC+ CP G +   F +  C
Sbjct: 1377 PCPPGFHGAGCQGLCWCQHGAPCDPISGRCL-CPAG-FHGHFCERGC 1421



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 48/226 (21%), Positives = 69/226 (30%), Gaps = 39/226 (17%)

Query: 627  CGVGQGHAENQCVS----CRAGTYYDGARERCILCPNGTF-QNEEGQMTCEPCPRPGN-S 680
            C    GH     +S    C AG       ++C   P G F    E +  C+      + S
Sbjct: 873  CNCSAGHGSCDAISGLCLCEAGYVGPRCEQQC---PQGHFGPGCEQRCQCQHGAACDHVS 929

Query: 681  GALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQ 740
            GA   P  W  + C   C  G +  D  + C  C  G        +   P G       +
Sbjct: 930  GACTCPAGWRGTFCEHACPAGFFGLDCRSACN-CTAGAACDAVNGSCLCPAG------RR 982

Query: 741  GATSFQDCETRVQCSPGHFYNTTTHRCIRCPVG-TYQPEFGKNNCV----------SCPG 789
            G    + C       P H Y     +   C  G +  P  G+ +C           +CP 
Sbjct: 983  GPRCAETC-------PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPA 1035

Query: 790  NTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTEC 835
                  D   +   C+N   GG     +G+   P          EC
Sbjct: 1036 GLYG--DNCRHSCLCQN---GGTCDPVSGHCACPEGWAGLACEKEC 1076



 Score = 30.4 bits (67), Expect = 8.7
 Identities = 47/199 (23%), Positives = 57/199 (28%), Gaps = 61/199 (30%)

Query: 626  SCGVGQGHAENQC-VSCRAGTYYDGARERCILCPNGTFQNEEGQMTC----------EPC 674
            SC  G G     C ++C  G Y       C    N T +   G   C           PC
Sbjct: 1319 SCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPC 1378

Query: 675  PRPGNSGA--------------------LKTPEAWNMSECGGLCQPGEY--------SAD 706
            P PG  GA                       P  ++   C   C+PG +          D
Sbjct: 1379 P-PGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCD 1437

Query: 707  GFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHR 766
            G APC         P  G   C P          GAT   DC        G F  + T  
Sbjct: 1438 GGAPC--------DPVTGLCLCPP-------GRSGATCNLDCRR------GQFGPSCTLH 1476

Query: 767  CIRCPVGTYQPEFGKNNCV 785
            C         P  G+ +CV
Sbjct: 1477 CDCGGGADCDPVSGQCHCV 1495


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  228 bits (581), Expect = 2e-59
 Identities = 141/414 (34%), Positives = 200/414 (48%), Gaps = 54/414 (13%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG--EGRQCEDIDECGNELNGGCVHDC 102
            D++EC+   + C  +  C N   +Y+CSC PGYQ   + + C DIDEC   +NGGC   C
Sbjct: 1200 DINECSLSDNLCR-NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDEC-MIMNGGCDTQC 1257

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161
             N  G+Y C+C +G+ L  DG +C D+DEC  N   C    C N+ G Y C C +GF  S
Sbjct: 1258 TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMAS 1317

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICK----EAPRGSVACECRPGFELAKNQRDC--IL 215
             +  TCI  +E  L+        S+IC     E  +GS  C C+ G+ + K    C  + 
Sbjct: 1318 MDMKTCIDVNECDLN--------SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVD 1369

Query: 216  TCNHGNGGCQH--SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273
             C  G   C    SC +     +CSC   +    +G  C++ ++       SN T     
Sbjct: 1370 ECEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDEC------SNGT----- 1416

Query: 274  DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333
                        C++N       C +T     C+C  GFT   DG TC D+DEC      
Sbjct: 1417 ----------HQCSIN-----AQCVNTPGSYRCACSEGFTG--DGFTCSDVDECAENINL 1459

Query: 334  CDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNR 391
            C++  C N+ G++ C C+ GF   +D +SCQD+DECS    C   +C N PG F C C+ 
Sbjct: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519

Query: 392  GYTLYGFT-HCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444
            GY L     +C D +EC+        +CVNT G YEC C P ++L+     CV+
Sbjct: 1520 GYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1573



 Score =  214 bits (544), Expect = 4e-55
 Identities = 140/445 (31%), Positives = 192/445 (43%), Gaps = 86/445 (19%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHD 101
            ED++ECAQ    C     C NT  SY+C+C  GY  + + + C+D+DEC   L     HD
Sbjct: 2252 EDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL-----HD 2304

Query: 102  C-------LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECC 153
            C        N+ G + C C  G     DG  C+D +EC    G C++  CVN++GSY C 
Sbjct: 2305 CESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE 2364

Query: 154  CKEGFFLSDNQHTCIHRSEEGLS------------------------CMNKDHGCSHICK 189
            C EGF  S +   C+  + +GL                         C +   G  H C+
Sbjct: 2365 CNEGFQSSSSGTECLD-NRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCE 2423

Query: 190  EAPRGSVA-----CECRPGFEL-AKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQY 243
              P    A     C   PG+    ++  +C +  N    G    C +T     C C   Y
Sbjct: 2424 LCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG---QCINTMGSFRCFCKVGY 2480

Query: 244  KMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTG 303
                 G SC++                            ++ C+ +   C+  CK+T   
Sbjct: 2481 TTDISGTSCID----------------------------LDECSQSPKPCNYICKNTEGS 2512

Query: 304  VHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQ 363
              CSCP G+ LQ DGKTCKD+DECQT+   C   C N +G F C C  GF       +C 
Sbjct: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--TQHHTACI 2570

Query: 364  DVDEC-SLDRTCDHS--CINHPGTFACACNRGYTLYGF-THCGDTNECSINNGGCQQVCV 419
            D +EC S    C     C N PG+F+C C RG++L     +C D +EC   N  CQ  C 
Sbjct: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD-GNHRCQHGCQ 2629

Query: 420  NTVGSYECQCHPGYKLHWNKKDCVE 444
            N +G Y C C  GY  H+    CV+
Sbjct: 2630 NILGGYRCGCPQGYIQHYQWNQCVD 2654



 Score =  213 bits (542), Expect = 7e-55
 Identities = 140/452 (30%), Positives = 201/452 (44%), Gaps = 55/452 (12%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ-GEGRQCEDIDECGNELNGGCVHD- 101
            ED+DEC+ G + C  +A C N+P SY+C C  G++      C D +EC  E+   C H  
Sbjct: 1849 EDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNEC-LEIPNVCSHGL 1907

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLEN---NGGCQHT---------------- 142
            C+++ G+Y+C C +GF  + D   C+DVDEC  +   NG C++T                
Sbjct: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967

Query: 143  ----------------------CVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK 180
                                  C N +GS++C C EG+ L+ +   CI  +E    C+  
Sbjct: 1968 NNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE----CVAL 2023

Query: 181  DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQH-SCDDTADGPECSC 239
               CS    +   GS  C C PG+E+       I  C+     C   SC +T  G +C C
Sbjct: 2024 PGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLC 2083

Query: 240  HPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGG--CDRT 296
             P + +  +GR C + R+       E+   SV       K +           G  C+  
Sbjct: 2084 PPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELC 2143

Query: 297  CKDTSTGVHCSCPVGF-TLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFK 354
             KD        CP G  T+     T +D++EC    G C +  C N  GSF C C  G+ 
Sbjct: 2144 PKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYN 2203

Query: 355  LLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGG 413
            L      C D DECS+   C + +C N  G+F C CN G+      +C D NEC+ N   
Sbjct: 2204 LDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLL 2263

Query: 414  CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            C   C+NT GSYEC C  GY L  ++K C ++
Sbjct: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDL 2295



 Score =  209 bits (531), Expect = 1e-53
 Identities = 139/474 (29%), Positives = 214/474 (45%), Gaps = 84/474 (17%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDEC--GNELNGGCV 99
            +D++EC      C     C+NT  S+KC C  G+    E R C DIDEC    +L G  +
Sbjct: 1072 KDINECKAFPGMC-TYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI 1130

Query: 100  HDCLNIPGNYRCTCFDG----FMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCC 154
              C+N PG++ C CF+G    FM+     NC+D+DEC  N   C+  TCVN  GS++C C
Sbjct: 1131 --CVNTPGSFECECFEGYESGFMMMK---NCMDIDECERNPLLCRGGTCVNTEGSFQCDC 1185

Query: 155  KEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC- 213
              G  LS ++  C+  +E    C   D+ C +       G+  C C PG++   +++ C 
Sbjct: 1186 PLGHELSPSREDCVDINE----CSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCT 1241

Query: 214  -ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVL--EVTESNTTSV 270
             I  C   NGGC   C ++    ECSC   Y +  DGRSC + ++     ++ +    + 
Sbjct: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTN 1301

Query: 271  VDGDKR------------VKRRLLMETCAVNNGGCD-RTCKDTSTGVHCSCPVGFTLQLD 317
            + G+ R            +K  + +  C +N+  C    C++T     C C +G++++  
Sbjct: 1302 IPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKG 1361

Query: 318  GKTCKDIDECQTRNGGCDHF--CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR--- 372
               C D+DEC+     CD    C NI GSF C C++G+  + +   C D+DECS      
Sbjct: 1362 TTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQC 1419

Query: 373  TCDHSCINHPGTFACACNRGYTLYGFT--------------------------------- 399
            + +  C+N PG++ CAC+ G+T  GFT                                 
Sbjct: 1420 SINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMG 1479

Query: 400  --------HCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
                     C D +ECS  N      C N  G + C C  GY+L     +C ++
Sbjct: 1480 FTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDI 1533



 Score =  185 bits (469), Expect = 2e-46
 Identities = 130/416 (31%), Positives = 188/416 (45%), Gaps = 29/416 (6%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVH-DCL 103
            DVDEC  G  +C   A C N P S+KCSC+ G+ G G +C D+DEC N  +   ++  C+
Sbjct: 1367 DVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCV 1426

Query: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSD 162
            N PG+YRC C +GF    DG  C DVDEC EN   C++  C+NV G+Y C C+ GF  + 
Sbjct: 1427 NTPGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPAS 1484

Query: 163  NQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHG 220
            +  +C    E    C  ++      C   P G   C C  G+EL +   +C  I  C   
Sbjct: 1485 DSRSCQDIDE----CSFQNICVFGTCNNLP-GMFHCICDDGYELDRTGGNCTDIDECADP 1539

Query: 221  NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE--DTVLEVTESNTTSVVDGDKRVK 278
                   C +T    EC+C P ++++  G  C++    +  L+       S +  +  + 
Sbjct: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGS-LSCNTEIG 1598

Query: 279  RRLLMETCAVNNG-----GCDRTCKDTSTGVHCSCPVGFTLQLDGKT--CKDIDECQTRN 331
              +   +C  + G      C+      ST  +  CP G   + +  T   +DIDECQ   
Sbjct: 1599 VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658

Query: 332  GGCD-HFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTC-DHSCINHPGTFACA 388
            G C    C N  GSF C C +G+ L  D + C+D+DEC +    C   +C N  G + C 
Sbjct: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCI 1718

Query: 389  CNRGY-TLYGFTHCGDTNEC----SINNGGCQQVCVNTVGSYECQCHPGYKLHWNK 439
            C   Y  + G  +C D  +     S N   C+      V    C C       WNK
Sbjct: 1719 CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNK 1774



 Score =  184 bits (467), Expect = 4e-46
 Identities = 130/440 (29%), Positives = 176/440 (40%), Gaps = 77/440 (17%)

Query: 33   PPGRGRAAGPQEDVDE--CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDID-- 88
            PPG  R    +  VDE  C      C  +  C N   SY+C C  G+Q      E +D  
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICE-NGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382

Query: 89   --------------------------ECGNELNGGCVHDC--LNIPGN--YRCTCFDGFM 118
                                      EC  +   G  H C    +PG   Y+  C  G  
Sbjct: 2383 QGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPG 2442

Query: 119  LAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSC 177
               DG    D+DEC      C +  C+N MGS+ C CK G+    +  +CI   E    C
Sbjct: 2443 YTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDE----C 2495

Query: 178  MNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGP 235
                  C++ICK    GS  C C  G+ L ++ + C  +  C      CQ  C +T  G 
Sbjct: 2496 SQSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554

Query: 236  ECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR 295
             C C P +  H                     T+ +D ++   +  L         G   
Sbjct: 2555 TCKCPPGFTQHH--------------------TACIDNNECGSQPSLC--------GAKG 2586

Query: 296  TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKL 355
             C++T     C C  GF+L   G  C+D+DEC   N  C H C+NI+G + CGC +G+  
Sbjct: 2587 ICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG-NHRCQHGCQNILGGYRCGCPQGYIQ 2645

Query: 356  LTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGG 413
                  C D +ECS    C   SC N  G++ CAC  G++   F+  C D NECS +   
Sbjct: 2646 HYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP 2705

Query: 414  CQQVCVNTVGSYECQCHPGY 433
            C   C NT G Y C C PGY
Sbjct: 2706 CNYGCSNTEGGYLCGCPPGY 2725



 Score =  179 bits (455), Expect = 9e-45
 Identities = 142/452 (31%), Positives = 197/452 (43%), Gaps = 69/452 (15%)

Query: 41   GPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGC 98
            G   D+DEC +    C A+ +C N   S++C C  G+        CEDIDEC N  N  C
Sbjct: 1804 GKAVDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDN-LC 1861

Query: 99   VH--DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCK 155
                DC+N PG+YRC C  GF L+ +G  C+D +ECLE    C H  CV++ GSY+C C 
Sbjct: 1862 QRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICH 1920

Query: 156  EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213
             GF  S +Q  C+   E    C  + H C +   +   GS  C C PGFEL  N  DC  
Sbjct: 1921 NGFKASQDQTMCMDVDE----C--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLD 1973

Query: 214  ILTCNHGNGG-CQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVL--EVTESNTTS 269
            I  C+   G  C++  C +     +C C+  Y++  DG++C++  + V         T  
Sbjct: 1974 IDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQ 2033

Query: 270  VVDGDKRV----KRRLLMETCAVNNGGCDR--------TCKDTSTGVHCSCPVGFTLQLD 317
             ++G  R        +  E C ++   CD         +C +T  G  C CP GF L  +
Sbjct: 2034 NLEGSFRCICPPGYEVKSENC-IDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDN 2092

Query: 318  GKTCKDIDE--CQT--RNGGCDHFCKNIVGSFDCGCKK--GFKLLTDEKSCQDVDECSLD 371
            G+ C D  +  C T   NG C            C C K  G       + C   DE +  
Sbjct: 2093 GRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQ 2152

Query: 372  RTCDH----------------SCINHP------------GTFACACNRGYTL-YGFTHCG 402
              C +                 C+  P            G+F C C  GY L Y    C 
Sbjct: 2153 DLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCV 2212

Query: 403  DTNECSINNGGCQQVCVNTVGSYECQCHPGYK 434
            DT+ECSI N      C N +GS+EC C+ G++
Sbjct: 2213 DTDECSIGNPCGNGTCTNVIGSFECNCNEGFE 2244



 Score =  177 bits (450), Expect = 3e-44
 Identities = 148/491 (30%), Positives = 202/491 (41%), Gaps = 103/491 (20%)

Query: 39  AAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNE--- 93
           A G   DVDEC    + C  +  C NTP SY C C  G+Q    +  C DIDEC      
Sbjct: 529 ANGDCIDVDECTS--NPC-TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVL 585

Query: 94  -LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC 152
             NG CV    N  G+++C C  GF L  DG NC+D DEC   N      C+N  GS++C
Sbjct: 586 CKNGRCV----NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC 641

Query: 153 CCKEGFFLSDNQHTCIHRSE---EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKN 209
            CK GF L+ N   C    E    G+ CMN      H       GS  C+C PG  +  +
Sbjct: 642 ICKPGFVLAPNGRYCTDVDECQTPGI-CMN-----GHCINS--EGSFRCDCPPGLAVGMD 693

Query: 210 QRDCI-----LTCNHG--NGGCQHSCDDTADGPECSC-HPQY---------------KMH 246
            R C+      TC  G   G C           EC C +P Y               + H
Sbjct: 694 GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753

Query: 247 ----------TDGRS----CLEREDTVLEVTES-------NTTSVVDGDKRVKRRLLMET 285
                      DGR      L+ +     + E+       N  S  + D   +  + ++ 
Sbjct: 754 GLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDE 813

Query: 286 CAVNNGGCDR-TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344
           C VN   CD   C++T     C+CP G+  + + +TC+DI+EC++ N   +  C+N +GS
Sbjct: 814 CLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECES-NPCVNGACRNNLGS 872

Query: 345 FDCGCKKGFKLLTDEKSCQDVDECSLDRTC-----DHSC-INHPGT-------------- 384
           F+C C  G KL +    C D    SL  TC     D  C +N  G               
Sbjct: 873 FNCECSPGSKLSSTGLICID----SLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAW 928

Query: 385 --------FACACNRGYTLYGFTHCGDTNECSINNGGCQQV-CVNTVGSYECQCHPGYKL 435
                      AC RG        C D NEC +  G C    CVN+ GS+ C+C  G  L
Sbjct: 929 GSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTL 988

Query: 436 HWNKKDCVEVK 446
               + C++++
Sbjct: 989 DGTGRVCLDIR 999



 Score =  172 bits (436), Expect = 1e-42
 Identities = 107/361 (29%), Positives = 149/361 (41%), Gaps = 47/361 (13%)

Query: 49   CAQGLDDCHADALCQNTPTS-YKCSCK--PGYQGEGRQCEDIDECGNELNGGCVHDCLNI 105
            C  G    H   LC    T+ YK  C   PGY  +GR   DIDEC    N      C+N 
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINT 2468

Query: 106  PGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQH 165
             G++RC C  G+     G +C+D+DEC ++   C + C N  GSY+C C  G+ L ++  
Sbjct: 2469 MGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGK 2528

Query: 166  TCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNG--- 222
            TC    E    C  K H C  +C     G   C+C PGF   ++   CI     G+    
Sbjct: 2529 TCKDLDE----CQTKQHNCQFLCVNT-LGGFTCKCPPGF--TQHHTACIDNNECGSQPSL 2581

Query: 223  -GCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281
             G +  C +T     C C   + +   G +C + ++              DG+ R     
Sbjct: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-------------DGNHR----- 2623

Query: 282  LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341
                       C   C++   G  C CP G+        C D +EC   N      C N 
Sbjct: 2624 -----------CQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNT 2672

Query: 342  VGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTLYGFTH 400
            +GS+ C C  GF       +C DV+ECS  +  C++ C N  G + C C  GY   G  H
Sbjct: 2673 LGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGH 2732

Query: 401  C 401
            C
Sbjct: 2733 C 2733



 Score =  171 bits (434), Expect = 2e-42
 Identities = 138/464 (29%), Positives = 191/464 (41%), Gaps = 75/464 (16%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNE---LNGGCV 99
            D+DEC      C  D  C N+  SY+CSC  GY    +GR C DIDEC N     +GG  
Sbjct: 1242 DIDECMIMNGGC--DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGG-- 1297

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGF 158
              C NIPG YRC C+DGFM + D   C+DV+EC  N+  C    C N  GS+ C C+ G+
Sbjct: 1298 -QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGY 1356

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILT-- 216
             +      C    E  +   N D   S  C   P GS  C CR G+    N   CI    
Sbjct: 1357 SVKKGTTGCTDVDECEIGAHNCDMHAS--CLNIP-GSFKCSCREGW--IGNGIKCIDLDE 1411

Query: 217  CNHGNGGCQHS--CDDTADGPECSCHPQYKMHTDGRSCLEREDTV--LEVTESNTTSVVD 272
            C++G   C  +  C +T     C+C   +    DG +C + ++    + + E+     V 
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVP 1469

Query: 273  GDKRVKRRLL------------METCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
            G  R +  +             ++ C+  N     TC +     HC C  G+ L   G  
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529

Query: 321  CKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD--VDECSL-------- 370
            C DIDEC       +  C N  G ++C C   F+L      C D  V  C L        
Sbjct: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589

Query: 371  DRTCDHSCINHPGTFACACNRG------------------YTLY----GFTH------CG 402
              +C+          +C C+ G                  YTL     GF          
Sbjct: 1590 SLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649

Query: 403  DTNECSINNGGCQQV-CVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            D +EC    G CQ   C+NT GS++C+C  GY L  + + C ++
Sbjct: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1693



 Score =  169 bits (429), Expect = 9e-42
 Identities = 133/476 (27%), Positives = 194/476 (40%), Gaps = 83/476 (17%)

Query: 51  QGLDDC-HADALCQN-----TPTSYKCSCKPGYQGEGR-QCEDIDEC-GNELNGGCVHDC 102
           Q +D C H   LC N     T +SY+C C  GY+ +    C D+DEC  N    G   DC
Sbjct: 493 QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNG---DC 549

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161
           +N PG+Y C C  GF        C+D+DEC++N   C++  CVN  GS++C C  GF L+
Sbjct: 550 VNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELT 609

Query: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
            +   C+   E    C   +   + +C     GS  C C+PGF LA N R C  +  C  
Sbjct: 610 TDGKNCVDHDE----CTTTNMCLNGMCINED-GSFKCICKPGFVLAPNGRYCTDVDECQT 664

Query: 220 GNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
                   C ++     C C P   +  DGR C++                         
Sbjct: 665 PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTH----------------------- 701

Query: 280 RLLMETC--AVNNGGCDRTCKDTSTGVHCSCP---VGFTLQLDGKTCKDIDECQTRNGGC 334
             +  TC   +  G C R      T   C C     GF     G+ C+    C  +N   
Sbjct: 702 --MRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF-----GEPCQP---CPAKNSA- 750

Query: 335 DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT--CDHSCINHPGTFACACNRG 392
                     F   C  G  +  D +   D++EC+LD     +  C N  G++ C CN G
Sbjct: 751 ---------EFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSG 798

Query: 393 YTLYGF-THCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP 450
           Y       +C D +EC +N   C   +C NT GSY C C PGY      + C ++     
Sbjct: 799 YEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDIN---E 855

Query: 451 TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSD----VTTIRTSVTFKLNEGKCSL 502
              +P V+  C  + G   C   C  G  LSS     + +++ +    + + +C +
Sbjct: 856 CESNPCVNGACRNNLGSFNC--ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEV 909



 Score =  169 bits (428), Expect = 1e-41
 Identities = 134/466 (28%), Positives = 189/466 (40%), Gaps = 88/466 (18%)

Query: 31   AVPPGRGRAAGPQ-EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDI 87
            A P G  R  G   EDV+EC      C  +  C N+  S+ C C  G    G GR C DI
Sbjct: 940  ACPRGLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGLTLDGTGRVCLDI 998

Query: 88   --DECGNELNGG-CVHDCLNIPGNYR---CTCFDGFMLAHDGHNC--------------- 126
              ++C  + +   C+H    +PG +R   C C  G     +   C               
Sbjct: 999  RMEQCYLKWDEDECIHP---VPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRG 1055

Query: 127  ----------------LDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIH 169
                             D++EC    G C +  C N +GS++C C  GF L   +  C  
Sbjct: 1056 AGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTD 1115

Query: 170  RSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFE----LAKNQRDCILTCNHGNGGCQ 225
              E  +S    D   S IC   P GS  CEC  G+E    + KN  D I  C      C+
Sbjct: 1116 IDECRIS---PDLCGSGICVNTP-GSFECECFEGYESGFMMMKNCMD-IDECERNPLLCR 1170

Query: 226  H-SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLME 284
              +C +T    +C C   +++      C++                            + 
Sbjct: 1171 GGTCVNTEGSFQCDCPLGHELSPSREDCVD----------------------------IN 1202

Query: 285  TCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVG 343
             C++++  C +  C +      CSC  G+    D + C DIDEC   NGGCD  C N  G
Sbjct: 1203 ECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262

Query: 344  SFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCD-HSCINHPGTFACACNRGY-TLYGFTH 400
            S++C C +G+ L+ D +SC D+DEC  +   CD   C N PG + C C  G+        
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322

Query: 401  CGDTNECSINNGGCQ-QVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            C D NEC +N+  C    C NT GS+ C C  GY +      C +V
Sbjct: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDV 1368



 Score =  161 bits (408), Expect = 2e-39
 Identities = 135/457 (29%), Positives = 188/457 (41%), Gaps = 101/457 (22%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDE-----------C 90
            ED+DEC      C     C NT  +Y C C P Y     G  C D+ +           C
Sbjct: 1691 EDIDECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749

Query: 91   GNELNGG-------CVHD--------CLNIP----GNYRCTC--FDGFMLAHDGHNCLDV 129
             NEL          C ++        C   P     +++  C    GF         +D+
Sbjct: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809

Query: 130  DECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH-- 186
            DEC E  G C +  C+N +GS+ C C  GF  +D    C    E+   C N D+ C    
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVC----EDIDECSNGDNLCQRNA 1865

Query: 187  ICKEAPRGSVACECRPGFELAKN-----QRDCI---LTCNHGNGGCQHSCDDTADGPECS 238
             C  +P GS  CEC  GF+L+ N     + +C+     C+HG       C D     +C 
Sbjct: 1866 DCINSP-GSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG------LCVDLQGSYQCI 1918

Query: 239  CHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCK 298
            CH  +K   D   C++ ++                          E     NG    TCK
Sbjct: 1919 CHNGFKASQDQTMCMDVDE-------------------------CERHPCGNG----TCK 1949

Query: 299  DTSTGVHCSCPVGFTLQLDGKTCKDIDECQT------RNGGCDHFCKNIVGSFDCGCKKG 352
            +T    +C C  GF L      C DIDEC +      RNG     C N +GSF C C +G
Sbjct: 1950 NTVGSYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCRNGR----CFNEIGSFKCLCNEG 2004

Query: 353  FKLLTDEKSCQDVDEC-SLDRTCD-HSCINHPGTFACACNRGYTLYGFTHCGDTNECSIN 410
            ++L  D K+C D +EC +L  +C   +C N  G+F C C  GY +    +C D NEC  +
Sbjct: 2005 YELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKS-ENCIDINECDED 2063

Query: 411  NGGCQ-QVCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446
               C    C NT G ++C C PG+ L  N + C + +
Sbjct: 2064 PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100



 Score =  157 bits (398), Expect = 4e-38
 Identities = 128/453 (28%), Positives = 180/453 (39%), Gaps = 67/453 (14%)

Query: 9    PGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAG---PQEDVDECAQGLDDCHADALCQNT 65
            PG  W     L      +      P G G        +EDV+EC +    C ++  C NT
Sbjct: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGIC-SNGQCINT 2190

Query: 66   PTSYKCSCKPGYQGE--GRQCEDIDEC--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAH 121
              S++C C  GY  +  G +C D DEC  GN    G    C N+ G++ C C +GF    
Sbjct: 2191 DGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGT---CTNVIGSFECNCNEGFEPG- 2246

Query: 122  DGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE--EGL-SCM 178
               NC D++EC +N   C   C+N  GSYEC C  G+ L ++Q  C    E  EGL  C 
Sbjct: 2247 PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCE 2306

Query: 179  NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI--LTCNHGNGGCQHS-CDDTADGP 235
            ++   C ++      G+  C C PG     +   C+    C    G C++  C +     
Sbjct: 2307 SRGMMCKNLI-----GTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSY 2361

Query: 236  ECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR 295
             C C+  ++  + G  CL+    +       T   +    R       E C     G   
Sbjct: 2362 RCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSR-NLVTKSECCCDGGRGWGH 2420

Query: 296  TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKL 355
             C+         CP+  T Q                       K I       C  G   
Sbjct: 2421 QCE--------LCPLPGTAQY----------------------KKI-------CPHGPGY 2443

Query: 356  LTDEKSCQDVDECS-LDRTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNECSINNG 412
             TD +   D+DEC  +   C +  CIN  G+F C C  GYT     T C D +ECS +  
Sbjct: 2444 TTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500

Query: 413  GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
             C  +C NT GSY+C C  GY L  + K C ++
Sbjct: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDL 2533



 Score =  117 bits (294), Expect = 4e-26
 Identities = 71/223 (31%), Positives = 99/223 (44%), Gaps = 14/223 (6%)

Query: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDEC 90
            PPG  +      D +EC      C A  +CQNTP S+ C C+ G+     G  CED+DEC
Sbjct: 2559 PPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC 2618

Query: 91   GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY 150
                N  C H C NI G YRC C  G++  +  + C+D +EC   N     +C N +GSY
Sbjct: 2619 DG--NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSY 2676

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
            +C C  GF        C   +E    C +  + C++ C     G   C C PG+     Q
Sbjct: 2677 KCACPSGFSFDQFSSACHDVNE----CSSSKNPCNYGCSNT-EGGYLCGCPPGY-YRVGQ 2730

Query: 211  RDCILTCNHGNGGCQHSCDDTADGPECSCHPQ--YKMHTDGRS 251
              C+       G  Q+   DT    E +  P+  Y+   +G S
Sbjct: 2731 GHCVSGMGFNKG--QYLSLDTEVDEENALSPEACYECKINGYS 2771



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 49/133 (36%), Positives = 64/133 (48%), Gaps = 8/133 (6%)

Query: 308 CPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVD 366
           C  GF   +    C+D+DECQ   G C    C N VGSF+C C  G K     + C+D+D
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 320

Query: 367 ECS-LDRTCD-HSCINHPGTFACACNRGY-TLYGFTHCGD--TNEC--SINNGGCQQVCV 419
           ECS +   C+   C N  G++ C C RGY T    + C D  T  C   + NG C Q   
Sbjct: 321 ECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELP 380

Query: 420 NTVGSYECQCHPG 432
             +   +C C PG
Sbjct: 381 GRMTKMQCCCEPG 393



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 12/155 (7%)

Query: 10  GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSY 69
           G AW     +    P     G +P  R    G  +DVDEC Q +        C NT  S+
Sbjct: 244 GRAWGHPCEMCPAQPQPCRRGFIPNIR---TGACQDVDEC-QAIPGICQGGNCINTVGSF 299

Query: 70  KCSCKPGY-QGEGRQ-CEDIDECGNELNGGC-VHDCLNIPGNYRCTCFDGFMLAHDGHNC 126
           +C C  G+ Q E  Q CEDIDEC + + G C   +C N  G+Y C C  G++ + DG  C
Sbjct: 300 ECRCPAGHKQSETTQKCEDIDEC-SIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358

Query: 127 LD--VDECLEN--NGGCQHTCVNVMGSYECCCKEG 157
           +D     C     NG C       M   +CCC+ G
Sbjct: 359 IDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 8/124 (6%)

Query: 84  CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-H 141
           C+D+DEC   + G C   +C+N  G++ C C  G   +     C D+DEC    G C+  
Sbjct: 274 CQDVDEC-QAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332

Query: 142 TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAP--RGSVACE 199
            C N +GSY C C  G+  S +   CI +   G+      +G     +E P     + C 
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQ-RTGMCFSGLVNG--RCAQELPGRMTKMQCC 389

Query: 200 CRPG 203
           C PG
Sbjct: 390 CEPG 393



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 67/260 (25%), Positives = 99/260 (38%), Gaps = 57/260 (21%)

Query: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG---------CDH 336
           C  ++G    TC   S    CS        ++G TC D D CQ + G          C++
Sbjct: 130 CTCSSGQISSTCGSKSIQ-QCSVRC-----MNGGTCAD-DHCQCQKGYIGTYCGQPVCEN 182

Query: 337 FCKN---IVGSFDCGCKKGFK--------------LLTDEKSCQD----------VDECS 369
            C+N    +G   C C  GF                  + + CQ           +   +
Sbjct: 183 GCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCAT 242

Query: 370 LDRTCDHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQV-CVNTVGSYEC 427
           + R   H C   P      C RG+     T  C D +EC    G CQ   C+NTVGS+EC
Sbjct: 243 IGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFEC 301

Query: 428 QCHPGYKLHWNKKDCVEVKGLLPTSVSPRV--SLHCGKSGGGDGCFLRCHSGIHLSSDVT 485
           +C  G+K     + C ++      S+ P +  +  C  + G   C   C  G   S+D +
Sbjct: 302 RCPAGHKQSETTQKCEDID---ECSIIPGICETGECSNTVGSYFCV--CPRGYVTSTDGS 356

Query: 486 TI---RTSVTFK-LNEGKCS 501
                RT + F  L  G+C+
Sbjct: 357 RCIDQRTGMCFSGLVNGRCA 376



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 54/194 (27%), Positives = 68/194 (35%), Gaps = 31/194 (15%)

Query: 648  DGARERCILCPNGTFQNEEGQMTCEPCPR--PGNSGALKTPEAWNMSECGGLCQ------ 699
            D  +E   +C NG   N+ G   CE CP     N   L   +    S    LCQ      
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCE-CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868

Query: 700  --PGEYSADGFAPCQLCALGTFQPEAGRTSCFP----CGGGLATKHQGATSFQD-CETRV 752
              PG Y  +  A  +L   G       R  C      C  GL    QG  S+Q  C    
Sbjct: 1869 NSPGSYRCECAAGFKLSPNGAC---VDRNECLEIPNVCSHGLCVDLQG--SYQCICHNGF 1923

Query: 753  QCSPGHFYNTTTHRCIR--CPVGTYQPEFGKNNCVSCPG------NTTTDFDGSTNI--T 802
            + S           C R  C  GT +   G  NC+  PG      N   D D  ++    
Sbjct: 1924 KASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQ 1983

Query: 803  QCKNRRCGGELGDF 816
             C+N RC  E+G F
Sbjct: 1984 VCRNGRCFNEIGSF 1997



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 61/283 (21%), Positives = 93/283 (32%), Gaps = 61/283 (21%)

Query: 71  CSCKPGYQGEGRQCEDIDECGNE-LNGG-CVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
           C+C  G        + I +C    +NGG C  D         C C  G++  + G    +
Sbjct: 130 CTCSSGQISSTCGSKSIQQCSVRCMNGGTCADD--------HCQCQKGYIGTYCGQPVCE 181

Query: 129 VDECLENNGGCQHTCVNVMGSYECCCKEGF--------------FLSDNQHTCIHR---- 170
            + C +N G C       +G   C C  GF              F   N   C  +    
Sbjct: 182 -NGC-QNGGRC-------IGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGI 232

Query: 171 -SEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQH- 226
              + L C        H C+  P  +    CR GF        C  +  C    G CQ  
Sbjct: 233 VCTKTLCCATIGRAWGHPCEMCP--AQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGG 290

Query: 227 SCDDTADGPECSCHPQYKMHTDGRSCLEREDT-----VLEVTESNTT------------- 268
           +C +T    EC C   +K     + C + ++      + E  E + T             
Sbjct: 291 NCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYV 350

Query: 269 SVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVG 311
           +  DG + + +R  M    + NG C +      T + C C  G
Sbjct: 351 TSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 37/145 (25%), Positives = 48/145 (33%), Gaps = 29/145 (20%)

Query: 641 CRAGTYYDGARERCI----------LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWN 690
           C AG      ++ CI          LC NG   N +G   C  C    N+G   T +  N
Sbjct: 560 CHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCI-C----NAGFELTTDGKN 614

Query: 691 MSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGG--LATKHQGATSFQDC 748
             +            D      +C  G    E G   C  C  G  LA   +  T   +C
Sbjct: 615 CVD-----------HDECTTTNMCLNGMCINEDGSFKCI-CKPGFVLAPNGRYCTDVDEC 662

Query: 749 ETRVQCSPGHFYNTTTHRCIRCPVG 773
           +T   C  GH  N+       CP G
Sbjct: 663 QTPGICMNGHCINSEGSFRCDCPPG 687



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 29/162 (17%)

Query: 648  DGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECG---GLCQPGEYS 704
            D      +LC  GT  N EG   C+ CP  G+  +    +  +++EC     LC+ G+  
Sbjct: 1160 DECERNPLLCRGGTCVNTEGSFQCD-CPL-GHELSPSREDCVDINECSLSDNLCRNGKC- 1216

Query: 705  ADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQD-------CETRVQCSPG 757
                    +  +GT+Q      SC P G       QG T   +       C+T+   S G
Sbjct: 1217 --------VNMIGTYQ-----CSCNP-GYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262

Query: 758  HFYNTTTHRCIRCPVGTYQPEFG--KNNCVSCPGNTTTDFDG 797
             +  + +      P G    +    +NN   C G   T+  G
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPG 1304



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 55/247 (22%), Positives = 90/247 (36%), Gaps = 39/247 (15%)

Query: 595 AVHREQFH-LQLSGMNLDVAKKPPRTSERQAESC--GVGQGHAENQCVSCRAGTYYDGAR 651
           A +  +FH L  SG+ + V  +         + C  G+ +    +   +C +G   D + 
Sbjct: 746 AKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASG 805

Query: 652 ERCI----------LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSEC------G 695
             CI          LC NG  +N  G  +C  CP PG     +T    +++EC       
Sbjct: 806 RNCIDIDECLVNRLLCDNGLCRNTPGSYSC-TCP-PGYVFRTETETCEDINECESNPCVN 863

Query: 696 GLCQP--GEYSADGFAPCQLCALGTFQPEAGRTSCF--PCGGGLATKHQGATSFQDCETR 751
           G C+   G ++ +     +L + G    ++ + +C+             GAT   +C   
Sbjct: 864 GACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCAT 923

Query: 752 VQCSPGHFYNTTTHRCIRCPVGTYQPE-FGKNNCVSCPG-NTTTDFDGSTNITQCKNRRC 809
           +  + G         C RC + T  P    +   V+C   N    F G      C N RC
Sbjct: 924 LGAAWG-------SPCERCELDTACPRGLARIKGVTCEDVNECEVFPG-----VCPNGRC 971

Query: 810 GGELGDF 816
               G F
Sbjct: 972 VNSKGSF 978


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  215 bits (547), Expect = 2e-55
 Identities = 156/525 (29%), Positives = 206/525 (39%), Gaps = 110/525 (20%)

Query: 33   PPGRGRAAGPQE---DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDE 89
            P G G   GP +   D+DEC +   D      C NT  SY+C C  GY   G +C D DE
Sbjct: 2112 PYGSGIIVGPDDSAVDMDECKE--PDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDE 2169

Query: 90   C--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVM 147
            C  GN    G    C N+ G + CTC +GF        C D++EC +N   C   CVN  
Sbjct: 2170 CSVGNPCGNGT---CKNVIGGFECTCEEGFEPG-PMMTCEDINECAQNPLLCAFRCVNTY 2225

Query: 148  GSYECCCKEGFFLSDNQHTCIHRSE--EGL-SCMNKDHGCSHI----------------- 187
            GSYEC C  G+ L +++  C    E  EG   C  K   C ++                 
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPD 2285

Query: 188  ---------CKEAP-----------RGSVACECRPGFELAKNQRDCILT----------- 216
                     C+  P           RGS  CEC  GF  + NQ +C+             
Sbjct: 2286 GEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQ 2345

Query: 217  --CNHGNGG------CQHSCDDTAD-GPECSCHPQY------KMHTDGRS---------- 251
              C  G+         +  CD     GP C   P        K+   GR           
Sbjct: 2346 NMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDE 2405

Query: 252  ------------CLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKD 299
                        C+    +   + ++  T  + G   V     +  C      C+  CK+
Sbjct: 2406 CKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVD----LNECNQAPKPCNFICKN 2461

Query: 300  TSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDE 359
            T     CSCP G+ LQ DG++CKD+DEC T+   C   C N +G F C C  GF      
Sbjct: 2462 TEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF--TQHH 2519

Query: 360  KSCQDVDECSLDRTCDHS---CINHPGTFACACNRGYTL-YGFTHCGDTNECSINNGGCQ 415
             SC D +EC+ D     S   C N PG+F C C RG++L    + C D +EC   N  CQ
Sbjct: 2520 TSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECE-GNHRCQ 2578

Query: 416  QVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLH 460
              C N +G Y C C  GY  H+    CV+    L   +    S H
Sbjct: 2579 HGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCH 2623



 Score =  207 bits (526), Expect = 5e-53
 Identities = 139/432 (32%), Positives = 193/432 (44%), Gaps = 44/432 (10%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVHD- 101
            D+DEC +    C    +C NT  SY+C C PG+Q       C DI+EC  EL+     + 
Sbjct: 1113 DIDECQRDPLLCRG-GVCHNTEGSYRCECPPGHQLSPNISACIDINEC--ELSAHLCPNG 1169

Query: 102  -CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFL 160
             C+N+ G Y+C C  G+    D   C+D+DEC   NGGC+  C N  GSYEC C+ GF L
Sbjct: 1170 RCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL 1229

Query: 161  SDNQHTCIHRSEEGLSCMNKDHGC-SHICKEAPRGSVACECRPGFELAKNQRDC--ILTC 217
              +Q +C    E    C +  + C    C   P G   C C  GF  +++ + C  +  C
Sbjct: 1230 MPDQRSCTDIDE----CEDNPNICDGGQCTNIP-GEYRCLCYDGFMASEDMKTCVDVNEC 1284

Query: 218  NHGNGGC-QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVL-------EVTESNTTS 269
            +     C   +C++T     C C   Y        C +  +  +           +NT  
Sbjct: 1285 DLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAG 1344

Query: 270  ----------VVDGDKRVKRRLLMETCAVNNGGCDR--TCKDTSTGVHCSCPVGFTLQLD 317
                      + DG K       ++ C+     C +   CK+T     C C  G+T   D
Sbjct: 1345 SFKCSCSPGWIGDGIKCTD----LDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GD 1398

Query: 318  GKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH 376
            G TC D+DEC      C +  C N  G + C C  GF    D K+C+D+DECSL   C  
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVF 1458

Query: 377  -SCINHPGTFACACNRGYTL-YGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYK 434
             +C N PG F C C  GY L     +C D NEC          CVNT GSY C C P ++
Sbjct: 1459 GTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFE 1518

Query: 435  LHWNKKDCVEVK 446
            L+  +  CV+ +
Sbjct: 1519 LNPTRVGCVDTR 1530



 Score =  196 bits (499), Expect = 7e-50
 Identities = 137/458 (29%), Positives = 204/458 (44%), Gaps = 48/458 (10%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEG---RQCEDIDECGNE---LNGGC 98
            D+DEC    D C     C NTP  ++C C  GY+      + C DIDEC  +     GG 
Sbjct: 1070 DIDECRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGV 1128

Query: 99   VHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEG 157
             H   N  G+YRC C  G  L+ +   C+D++EC  +   C +  CVN++G Y+C C  G
Sbjct: 1129 CH---NTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPG 1185

Query: 158  FFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--IL 215
            +  + ++  C+   E    C   + GC   C  +  GS  C C+PGF L  +QR C  I 
Sbjct: 1186 YHSTPDRLFCVDIDE----CSIMNGGCETFCTNS-EGSYECSCQPGFALMPDQRSCTDID 1240

Query: 216  TCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLE-------VTESNT 267
             C      C    C +      C C+  +    D ++C++  +  L          E+  
Sbjct: 1241 ECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTK 1300

Query: 268  TSVV-------DGDKRVKRRLLMETCAVNNGGCDR--TCKDTSTGVHCSCPVGFTLQLDG 318
             S +        G K       +  C +    C +   C +T+    CSC  G+    DG
Sbjct: 1301 GSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG--DG 1358

Query: 319  KTCKDIDECQTRNGGCDHF--CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS--LDRTC 374
              C D+DEC      C     CKN +GS+ C CK+G+    D  +C D+DECS  L+   
Sbjct: 1359 IKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSENLNLCG 1416

Query: 375  DHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGY 433
            +  C+N PG + C C+ G+        C D +ECS+ N      C N  G + C+C  GY
Sbjct: 1417 NGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGY 1476

Query: 434  KLHWNKKDCVEVKGLL-PTSVSPRVSLHCGKSGGGDGC 470
            +L  +  +C +V   L PT+    +S +C  + G   C
Sbjct: 1477 ELDRSGGNCTDVNECLDPTTC---ISGNCVNTPGSYIC 1511



 Score =  191 bits (484), Expect = 4e-48
 Identities = 136/452 (30%), Positives = 198/452 (43%), Gaps = 66/452 (14%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR-QCEDIDECGNELNGGCVHD- 101
            ED+DEC  G   C  +A C NT  SY+C CKPGY+     QC D +EC  E+   C H  
Sbjct: 1807 EDIDECQNG-PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNEC-QEIPNICSHGQ 1864

Query: 102  ----------------------------------------CLNIPGNYRCTCFDGFMLAH 121
                                                    C N  G++ C C  GF+L+H
Sbjct: 1865 CIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSH 1924

Query: 122  DGHNCLDVDECLENNGG-CQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179
            + ++C+DVDEC   NG  C++  C+N +GS++C C EG+ ++ +  TC+  +E    C+ 
Sbjct: 1925 N-NDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE----CLL 1979

Query: 180  KDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQ-HSCDDTADGPECS 238
            +   C+    +   GS  C C PG+ L   + + I  C      C   +C +T    +C 
Sbjct: 1980 EPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCL 2039

Query: 239  CHPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
            C   + + + GR C + R        E    S        K+      CA+   G    C
Sbjct: 2040 CPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC---CALKGEGWGDPC 2096

Query: 298  K----DTSTGVHCSCPVGFTLQLD-GKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKK 351
            +    +        CP G  + +    +  D+DEC+  +  C H  C N  GS+ C C  
Sbjct: 2097 ELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDV-CKHGQCINTDGSYRCECPF 2155

Query: 352  GFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGFTHCGDTNECSIN 410
            G+ L  +E  C D DECS+   C + +C N  G F C C  G+       C D NEC+ N
Sbjct: 2156 GYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQN 2213

Query: 411  NGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
               C   CVNT GSYEC+C  GY L  +++ C
Sbjct: 2214 PLLCAFRCVNTYGSYECKCPVGYVLREDRRMC 2245



 Score =  187 bits (476), Expect = 3e-47
 Identities = 137/426 (32%), Positives = 187/426 (43%), Gaps = 48/426 (11%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDC 102
            DVDECA G  +   +  C NT  S++C C  GY+   +GR C DI+EC  E        C
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTC 1989

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMGSYECCCKEGFFLS 161
             N+ G+YRC C  G+ L ++   C D+DEC+E    C   TC N  GS++C C EGF LS
Sbjct: 1990 QNLDGSYRCICPPGYSLQNE--KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLS 2047

Query: 162  DNQHTC-------IHRSEEGLSCMN---KDHGCSHICKEAPRGSVACECRPGFELAKNQR 211
             +   C        +   EG  C +   ++H     C           C    EL   + 
Sbjct: 2048 SSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPC----ELCPTEP 2103

Query: 212  DCILT--CNHGNGGCQHSCDDTADGPECS----CHPQYKMHTDGR-SCLEREDTVLEVTE 264
            D      C +G+G      D   D  EC     C     ++TDG   C      +L   E
Sbjct: 2104 DEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNE 2163

Query: 265  SNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                  VD D+          C+V N   + TCK+   G  C+C  GF       TC+DI
Sbjct: 2164 C-----VDTDE----------CSVGNPCGNGTCKNVIGGFECTCEEGFEPG-PMMTCEDI 2207

Query: 325  DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR-TCDH---SCIN 380
            +EC      C   C N  GS++C C  G+ L  D + C+D DEC   +  C      C N
Sbjct: 2208 NECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKN 2267

Query: 381  HPGTFACACNRGYTLY-GFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWN 438
              GT+ C C  GY        C D NEC    G C+   C+NT GSY C+C+ G+    N
Sbjct: 2268 LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPN 2327

Query: 439  KKDCVE 444
            + +C++
Sbjct: 2328 QDECLD 2333



 Score =  178 bits (452), Expect = 2e-44
 Identities = 139/441 (31%), Positives = 198/441 (44%), Gaps = 47/441 (10%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE--GRQCEDIDECG-NEL---NGGC 98
            D++ECA   D C  + +C+N   +YKC C  GY+ +  G+ C DI+EC  N L   NG  
Sbjct: 723  DINECALDPDIC-PNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNG-- 779

Query: 99   VHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGF 158
               C N PG++ CTC  GF+   D   C D+DEC E++      C N  GS+ C C    
Sbjct: 780  --QCRNTPGSFVCTCPKGFIYKPDLKTCEDIDEC-ESSPCINGVCKNSPGSFICECSSES 836

Query: 159  FLSDNQHTCIHRSE--------EGLSCMN------KDHGCSHICKEAPRGSVACE----C 200
             L   +  CI   +        +G   +N      K   CS +          C+    C
Sbjct: 837  TLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPIC 896

Query: 201  RPGFELAKN-QRDCILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLE--RE 256
              G+   K  Q + I  C    G C++  C +T    +C C     +   GR CL+   E
Sbjct: 897  GKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLE 956

Query: 257  DTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP--VGFTL 314
               L   +   T  + G  R+         A     C+      +      CP   GF  
Sbjct: 957  TCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFAT 1016

Query: 315  Q--LDGKTC-KDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-- 368
            +   +GK   KDI+EC+     C H  C+N +GSF C C  GF L ++E++C D+DEC  
Sbjct: 1017 KEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRI 1076

Query: 369  SLDRTCDHSCINHPGTFACACNRGYTLYGF---THCGDTNECSINNGGCQ-QVCVNTVGS 424
            S D      C+N PG F C C+ GY   GF    +C D +EC  +   C+  VC NT GS
Sbjct: 1077 SPDLCGRGQCVNTPGDFECKCDEGYE-SGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGS 1135

Query: 425  YECQCHPGYKLHWNKKDCVEV 445
            Y C+C PG++L  N   C+++
Sbjct: 1136 YRCECPPGHQLSPNISACIDI 1156



 Score =  177 bits (449), Expect = 4e-44
 Identities = 120/368 (32%), Positives = 162/368 (44%), Gaps = 36/368 (9%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE--GRQCEDIDEC---GNELNGGCV 99
           DVDEC +  + C A   C N   SY C C+ GYQ      +C DIDEC   G   N G  
Sbjct: 490 DVDECEK--NPC-AGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG-- 544

Query: 100 HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFF 159
             C+N  G++ C C  GF +  DG NC D+DEC   N      C+N  GS++C CK GF 
Sbjct: 545 -RCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQ 603

Query: 160 LSDNQHTC--IHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI--- 214
           L+ +   C  I+  E    CMN        C     GS  CEC PG  +  + R C+   
Sbjct: 604 LASDGRYCKDINECETPGICMNGR------CVNTD-GSYRCECFPGLAVGLDGRVCVDTH 656

Query: 215 --LTCNHG--NGGCQHSCDDTADGPECSC-HPQYKMHTDGRSCLEREDTVLEVTESNTTS 269
              TC  G   G C           EC C   +Y      + C  +     +   S+   
Sbjct: 657 MRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPG 716

Query: 270 VVDGDKRVKRRLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQ 328
           +      +        CA++   C +  C++      C C  G+ +   GK C DI+EC 
Sbjct: 717 MTSAGSDINE------CALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECV 770

Query: 329 TRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFAC 387
             +  CD+  C+N  GSF C C KGF    D K+C+D+DEC      +  C N PG+F C
Sbjct: 771 LNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFIC 830

Query: 388 ACNRGYTL 395
            C+   TL
Sbjct: 831 ECSSESTL 838



 Score =  176 bits (445), Expect = 1e-43
 Identities = 148/566 (26%), Positives = 209/566 (36%), Gaps = 134/566 (23%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELN----GGCVH 100
            D+DEC+ G   C   A C+NT  SY+C CK GY G+G  C D+DEC   LN    G C++
Sbjct: 1363 DLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLN 1422

Query: 101  -------------------------------------DCLNIPGNYRCTCFDGFMLAHDG 123
                                                  C N+PG +RC C  G+ L   G
Sbjct: 1423 APGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSG 1482

Query: 124  HNCLDVDECLEN----NGGCQHT------------------------------------- 142
             NC DV+ECL+     +G C +T                                     
Sbjct: 1483 GNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRG 1542

Query: 143  ------CVNVMG----SYECCCKEGFFLSDNQHTC--IHRSEEGLSCMN----KDHGCSH 186
                  C N +G       CCC  G         C  ++ SE  + C      + +  + 
Sbjct: 1543 DNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITV 1602

Query: 187  I------CKEAPR-----------GSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHS 227
            I      C+E P            GS  C C  G+ L ++ R C  +  C         +
Sbjct: 1603 ILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGT 1662

Query: 228  CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCA 287
            C +T     C C P Y     G +C++   ++            DG+        M  C+
Sbjct: 1663 CYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCS 1722

Query: 288  VNNGG--------CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FC 338
             N G         C     D    +  S   GF + +      DIDEC+   G C++  C
Sbjct: 1723 YNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVC 1782

Query: 339  KNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS--CINHPGTFACACNRGYTLY 396
             N+VGSF C C  GF        C+D+DEC     C  +  CIN  G++ C C  GY   
Sbjct: 1783 INMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFT 1842

Query: 397  GFTHCGDTNEC-SINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSP 455
                C D NEC  I N      C++TVGS+ C CH G+K + ++  C+++      +   
Sbjct: 1843 STGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGN 1902

Query: 456  RVSLHCGKSGGGDGCFLRCHSGIHLS 481
                 C  + G   C  RC+ G  LS
Sbjct: 1903 GT---CRNTIGSFNC--RCNHGFILS 1923



 Score =  175 bits (444), Expect = 2e-43
 Identities = 128/423 (30%), Positives = 179/423 (42%), Gaps = 41/423 (9%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVH-DCL 103
            D++EC  G  +C   A+C NT  S+KCSC PG+ G+G +C D+DEC N  +    H DC 
Sbjct: 1322 DINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCK 1381

Query: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSD 162
            N  G+YRC C +G+    DG  C D+DEC EN   C +  C+N  G Y C C  GF  S 
Sbjct: 1382 NTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSA 1439

Query: 163  NQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI-------- 214
            +   C    E+   C   +      C   P G   CEC  G+EL ++  +C         
Sbjct: 1440 DGKAC----EDIDECSLPNICVFGTCHNLP-GLFRCECEIGYELDRSGGNCTDVNECLDP 1494

Query: 215  LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE--DTVLEVTESNTTSVVD 272
             TC  GN      C +T     C C P ++++     C++    +  L++          
Sbjct: 1495 TTCISGN------CVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTA 1548

Query: 273  GDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCS-----CPVGFTLQLDGKTC--KDID 325
                +   +   +C  + G    T  +    V+ S     CP G   + +  T   +DID
Sbjct: 1549 CSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDID 1608

Query: 326  ECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC-DHSCINHPG 383
            ECQ   G C    C N  GSF C C  G+ L  D + C DV+EC     C   +C N  G
Sbjct: 1609 ECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVG 1668

Query: 384  TFACACNRGY-TLYGFTHCGDTNE--CSIN----NGGCQQVCVNTVGSYECQCHPGYKLH 436
             + C C   Y  + G  +C D     C  N    N  C    +  +    C C       
Sbjct: 1669 NYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRA 1728

Query: 437  WNK 439
            WNK
Sbjct: 1729 WNK 1731



 Score =  173 bits (439), Expect = 6e-43
 Identities = 138/492 (28%), Positives = 186/492 (37%), Gaps = 112/492 (22%)

Query: 44   EDVDECAQGLDDCHADAL-CQNTPTSYKCSCKPGYQ----GEGR---------------- 82
            +D DEC +G  DC    + C+N   +Y C C PGYQ    GEG                 
Sbjct: 2246 KDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENG 2305

Query: 83   -----------QCED-------IDECGNELNGGCVHDCL-----------NIPGNYRCTC 113
                       +C D        DEC +   G C  + L           N      C C
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCC 2365

Query: 114  --------------FDGFM----LAHDGH----NCLDVDECLENNGGCQH-TCVNVMGSY 150
                          F G +    L   G     N  D+DEC   +  C++  CVN  GSY
Sbjct: 2366 DGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSY 2425

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
             C CK G+       +C+  +E    C      C+ ICK    GS  C C  G+ L ++ 
Sbjct: 2426 HCICKTGYTPDITGTSCVDLNE----CNQAPKPCNFICKNT-EGSYQCSCPKGYILQEDG 2480

Query: 211  RDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTT 268
            R C  +  C      CQ  C +T  G  C C P +  H    SC++  +           
Sbjct: 2481 RSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT--SCIDNNEC---------- 2528

Query: 269  SVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQ 328
                            T  +N  G    C++T     C C  GF+L   G +C+D+DEC+
Sbjct: 2529 ----------------TSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECE 2572

Query: 329  TRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFAC 387
              N  C H C+NI+G + C C +G+        C D +EC     C   SC N  G++ C
Sbjct: 2573 G-NHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKC 2631

Query: 388  ACNRGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446
             C  G+    F+  C D NEC      C   C NT G Y C C PGY     +  CV   
Sbjct: 2632 MCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY-FRIGQGHCVSGM 2690

Query: 447  GLLPTSVSPRVS 458
            G+   +  P VS
Sbjct: 2691 GMGRGNPEPPVS 2702



 Score =  172 bits (436), Expect = 1e-42
 Identities = 146/509 (28%), Positives = 197/509 (38%), Gaps = 122/509 (23%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVHDC 102
            D++EC      C  +  C N    Y+C+C PGY     +  C DIDEC + +NGGC   C
Sbjct: 1155 DINECELSAHLC-PNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC-SIMNGGCETFC 1212

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161
             N  G+Y C+C  GF L  D  +C D+DEC +N   C    C N+ G Y C C +GF  S
Sbjct: 1213 TNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMAS 1272

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
            ++  TC+  +E  L   N +   S  C E  +GS  C C  G+   K +  C  I  C  
Sbjct: 1273 EDMKTCVDVNECDL---NPNICLSGTC-ENTKGSFICHCDMGYSGKKGKTGCTDINECEI 1328

Query: 220  GNGGC-QHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRV 277
            G   C +H+ C +TA   +CSC P +    DG  C + ++       SN T +       
Sbjct: 1329 GAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDEC------SNGTHMCSQHADC 1380

Query: 278  KRRLLMETCAVNNG--GCDRTCKDTST------------------GVHCSCPVGFTLQLD 317
            K  +    C    G  G   TC D                     G  C C +GF    D
Sbjct: 1381 KNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSAD 1440

Query: 318  GKTCKDIDECQTRN----GGCDHF------------------------------------ 337
            GK C+DIDEC   N    G C +                                     
Sbjct: 1441 GKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISG 1500

Query: 338  -CKNIVGSFDCGCKKGFKLLTDEKSCQDV--DECSLD-----RTCDHSCINHPGT----F 385
             C N  GS+ C C   F+L      C D     C LD        D +C N  G      
Sbjct: 1501 NCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKA 1560

Query: 386  ACACNRG-----------------YTLY-----GFTH------CGDTNECSINNGGCQQ- 416
            +C C+ G                 Y +      GF          D +EC    G CQ  
Sbjct: 1561 SCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGG 1620

Query: 417  VCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
             C+NT GS++C+C  GY L+ + + C +V
Sbjct: 1621 KCINTFGSFQCRCPTGYYLNEDTRVCDDV 1649



 Score =  170 bits (430), Expect = 7e-42
 Identities = 131/441 (29%), Positives = 189/441 (42%), Gaps = 81/441 (18%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCEDIDECGNELNGGCVHDC 102
            D+DEC +    C  + +C N   S++C C  G  Y  +   CEDIDEC N        +C
Sbjct: 1766 DIDECREIPGVCE-NGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAEC 1824

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161
            +N  G+YRC C  G+     G  C D +EC E    C H  C++ +GS+ C C  GF  +
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTG-QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTN 1883

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILT--CNH 219
            D+Q  C+  +E       +D   +  C+    GS  C C  GF L+ N  DCI    C  
Sbjct: 1884 DDQTMCLDINE-----CERDACGNGTCRNT-IGSFNCRCNHGFILSHN-NDCIDVDECAS 1936

Query: 220  GNGG-CQH-SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRV 277
            GNG  C++  C +T    +C C+  Y++  DGR+C++  + +LE  +             
Sbjct: 1937 GNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRK------------- 1983

Query: 278  KRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCD-H 336
                    CA        TC++      C CP G++LQ   + C+DIDEC      C   
Sbjct: 1984 --------CAPG------TCQNLDGSYRCICPPGYSLQ--NEKCEDIDECVEEPEICALG 2027

Query: 337  FCKNIVGSFDCGCKKGFKLLTDEKSCQDV-----------DECSLDRTCDHS-------- 377
             C N  GSF C C +GF L +  + CQD+            +CS  ++ +HS        
Sbjct: 2028 TCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCAL 2087

Query: 378  -----------CINHPGTF---ACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVG 423
                       C   P       C    G  +       D +EC   +      C+NT G
Sbjct: 2088 KGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDG 2147

Query: 424  SYECQCHPGYKLHWNKKDCVE 444
            SY C+C  GY L  N  +CV+
Sbjct: 2148 SYRCECPFGYILAGN--ECVD 2166



 Score =  169 bits (428), Expect = 1e-41
 Identities = 125/413 (30%), Positives = 188/413 (45%), Gaps = 46/413 (11%)

Query: 61  LCQN-----TPTSYKCSCKPGYQGEGR-QCEDIDECG-NELNGGCVHDCLNIPGNYRCTC 113
           LCQN     TP S +C C  G+Q + R +C D+DEC  N   GG   +C+N  G+Y C C
Sbjct: 459 LCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGG---ECINNQGSYTCQC 515

Query: 114 FDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSE 172
             G+        C D+DECL+N   C +  C+N  GS+ C C  GF ++ +   C    E
Sbjct: 516 RAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDE 575

Query: 173 EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDD 230
             +  M  +  C +       GS  C C+PGF+LA + R C  I  C          C +
Sbjct: 576 CSIRNMCLNGMCIN-----EDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVN 630

Query: 231 TADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNN 290
           T     C C P   +  DGR C+          +++  S   G  +  + +     AV  
Sbjct: 631 TDGSYRCECFPGLAVGLDGRVCV----------DTHMRSTCYGGYKRGQCIKPLFGAVTK 680

Query: 291 GGCDRTCKDTSTGVHCS-CPVGFTLQLD-------GKTC--KDIDECQTRNGGCDH-FCK 339
             C     + + G  C  CP   + +         G T    DI+EC      C +  C+
Sbjct: 681 SECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICE 740

Query: 340 NIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR-TCDH-SCINHPGTFACACNRGYTLY- 396
           N+ G++ C C  G+++ +  K+C D++EC L+   CD+  C N PG+F C C +G+ +Y 
Sbjct: 741 NLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGF-IYK 799

Query: 397 -GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE-VKG 447
                C D +EC  ++     VC N+ GS+ C+C     L   K  C+E +KG
Sbjct: 800 PDLKTCEDIDECE-SSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKG 851



 Score =  165 bits (418), Expect = 2e-40
 Identities = 149/536 (27%), Positives = 200/536 (37%), Gaps = 103/536 (19%)

Query: 10   GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQ-EDVDECAQGLDDCHADALCQNTPTS 68
            GAAW     L  + P+         G  R  G Q ED+DEC      C  + LC NT  S
Sbjct: 880  GAAWGSPCTLCQVDPIC------GKGYSRIKGTQCEDIDECEVFPGVCK-NGLCVNTRGS 932

Query: 69   YKCSCKPGY--QGEGRQCEDI-----------DEC-----GNELNGGC---------VHD 101
            +KC C  G      GR C DI           +EC     G      C           +
Sbjct: 933  FKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEE 992

Query: 102  CLNIPGNYR------CTCFDGFM---LAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYE 151
            C   P          C    GF    + +      D++EC      C H  C N +GS++
Sbjct: 993  CEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFK 1052

Query: 152  CCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH-ICKEAPRGSVACECRPGFE----L 206
            C C  GF L   +  C    E    C      C    C   P G   C+C  G+E    +
Sbjct: 1053 CRCDSGFALDSEERNCTDIDE----CRISPDLCGRGQCVNTP-GDFECKCDEGYESGFMM 1107

Query: 207  AKNQRDCILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTES 265
             KN  D I  C      C+   C +T     C C P +++  +  +C++  +  L     
Sbjct: 1108 MKNCMD-IDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSA--- 1163

Query: 266  NTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDID 325
                                C   NG     C +      C+C  G+    D   C DID
Sbjct: 1164 ------------------HLCP--NG----RCVNLIGKYQCACNPGYHSTPDRLFCVDID 1199

Query: 326  ECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCD-HSCINHPG 383
            EC   NGGC+ FC N  GS++C C+ GF L+ D++SC D+DEC  +   CD   C N PG
Sbjct: 1200 ECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPG 1259

Query: 384  TFACACNRGY-TLYGFTHCGDTNECSINNGGC-QQVCVNTVGSYECQCHPGYKLHWNKKD 441
             + C C  G+        C D NEC +N   C    C NT GS+ C C  GY     K  
Sbjct: 1260 EYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTG 1319

Query: 442  CVEV-----------KGLLPTSVSPRVSLHCGKSGGGDGC----FLRCHSGIHLSS 482
            C ++           K  + T+ +      C     GDG        C +G H+ S
Sbjct: 1320 CTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCS 1375



 Score =  158 bits (399), Expect = 3e-38
 Identities = 216/853 (25%), Positives = 306/853 (35%), Gaps = 176/853 (20%)

Query: 33   PPGRGRAAGP----QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCED 86
            P G G    P     ED+DEC Q L        C NT  S++C C  GY    + R C+D
Sbjct: 1590 PGGEGFRPNPITVILEDIDEC-QELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDD 1648

Query: 87   IDECGNELNGGC-VHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL------ENNGGC 139
            ++EC  E  G C    C N  GNY C C   +M  + G+NC+D+   L       +N  C
Sbjct: 1649 VNEC--ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSV--- 196
                +  M    CCC                        N     +  C++ P  S    
Sbjct: 1707 DGELLFNMTKKMCCCS----------------------YNIGRAWNKPCEQCPIPSTDEF 1744

Query: 197  ACEC---RPGF--ELAKNQRDCILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGR 250
            A  C   RPGF  ++       I  C    G C++  C +      C C P    + D  
Sbjct: 1745 ATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCEC-PVGFFYND-- 1801

Query: 251  SCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRT--CKDTSTGVHCSC 308
              L  ED                         ++ C  N   C R   C +T+    C C
Sbjct: 1802 KLLVCED-------------------------IDECQ-NGPVCQRNAECINTAGSYRCDC 1835

Query: 309  PVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
              G+     G+ C D +ECQ     C H  C + VGSF C C  GFK   D+  C D++E
Sbjct: 1836 KPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINE 1894

Query: 368  CSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGG-CQQ-VCVNTVGSY 425
            C  D   + +C N  G+F C CN G+ L     C D +EC+  NG  C+   C+NTVGS+
Sbjct: 1895 CERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSF 1954

Query: 426  ECQCHPGYKLHWNKKDCVEVKGLL--PTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSD 483
            +CQC+ GY++  + + CV++   L  P   +P     C    G   C   C  G  L ++
Sbjct: 1955 QCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGT---CQNLDGSYRCI--CPPGYSLQNE 2009

Query: 484  VTTIRTSVTFKLNEGK-CSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPG 542
                   +   + E + C+L          +   PE  S      R  +L  S       
Sbjct: 2010 KC---EDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSY-CYAKF 2065

Query: 543  APGRPSTPKEMFITVEFELETNQKEVTASCDLS-------CIVKRTEKRLRKAIRTLRKA 595
              G+ S+PK            N  +    C L        C +  TE    +A R +   
Sbjct: 2066 EGGKCSSPK----------SRNHSKQECCCALKGEGWGDPCELCPTEP--DEAFRQICPY 2113

Query: 596  VHREQFHLQLSGMNLDVAKKPPRTSERQAES--------CGVGQGHAENQCV---SCRAG 644
                      S +++D  K+P      Q  +        C  G   A N+CV    C  G
Sbjct: 2114 GSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVG 2173

Query: 645  TYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGG---LCQPG 701
                        C NGT +N  G   C  C      G + T E  +++EC     LC   
Sbjct: 2174 N----------PCGNGTCKNVIGGFEC-TCEEGFEPGPMMTCE--DINECAQNPLLCAFR 2220

Query: 702  EYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQ-----CSP 756
              +  G   C+ C +G    E  R  C         KH       +C+  +      C P
Sbjct: 2221 CVNTYGSYECK-CPVGYVLRE-DRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGP 2278

Query: 757  GHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDF 816
            G+        C+            +N C + PG              C+N RC    G +
Sbjct: 2279 GYQRRPDGEGCV-----------DENECQTKPG-------------ICENGRCLNTRGSY 2314

Query: 817  T-----GYIESPN 824
            T     G+  SPN
Sbjct: 2315 TCECNDGFTASPN 2327



 Score =  118 bits (295), Expect = 3e-26
 Identities = 78/249 (31%), Positives = 113/249 (45%), Gaps = 21/249 (8%)

Query: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE--GRQCEDIDEC 90
            PPG  +      D +EC   ++ C +  +CQNTP S+ C C+ G+  +  G  CED+DEC
Sbjct: 2512 PPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDEC 2571

Query: 91   GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY 150
              E N  C H C NI G YRC+C  G++  +  + C+D +ECL  +     +C N +GSY
Sbjct: 2572 --EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSY 2629

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
            +C C  GF        C   +E G +     +GCS+       G   C C PG+     Q
Sbjct: 2630 KCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSN-----TEGGYLCGCPPGY-FRIGQ 2683

Query: 211  RDCILTCNHGNGG----CQHSCDDTADGP----ECSCHPQYKMHTDGRSCLEREDTVLE- 261
              C+     G G          DD +  P    EC  +   K     RS  E + + +E 
Sbjct: 2684 GHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECKINGYPKRGRKRRSTNETDASNIED 2743

Query: 262  --VTESNTT 268
               TE+N +
Sbjct: 2744 QSETEANVS 2752



 Score =  105 bits (263), Expect = 2e-22
 Identities = 62/191 (32%), Positives = 98/191 (51%), Gaps = 11/191 (5%)

Query: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLL 356
           C  T     C C  GF L L G+ C D+DEC+ +N      C N  GS+ C C+ G++  
Sbjct: 465 CIPTPGSCRCECNKGFQLDLRGE-CIDVDECE-KNPCAGGECINNQGSYTCQCRAGYQST 522

Query: 357 TDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRGYTLY-GFTHCGDTNECSINNGG 413
                C+D+DEC  + R C++  CIN  G+F C CN G+ +     +C D +ECSI N  
Sbjct: 523 LTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMC 582

Query: 414 CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCF-L 472
              +C+N  GS++C C PG++L  + + C ++        +P + ++ G+    DG +  
Sbjct: 583 LNGMCINEDGSFKCICKPGFQLASDGRYCKDIN----ECETPGICMN-GRCVNTDGSYRC 637

Query: 473 RCHSGIHLSSD 483
            C  G+ +  D
Sbjct: 638 ECFPGLAVGLD 648



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 94/361 (26%), Positives = 134/361 (37%), Gaps = 67/361 (18%)

Query: 96  GGCVHDCLNIPG----NYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYE 151
           GG  HD L  P      Y   C  G+     G+ C+           C+H+C +   S  
Sbjct: 46  GGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPI--------CRHSCGDGFCSRP 97

Query: 152 --CCCKEGFFLSDNQHTCIHRSEE--GLSCMNKDHGCSHICKEAPRGSVACECRPGFELA 207
             C C  G        +C  RS +   + CMN    CS       +G +   C       
Sbjct: 98  NMCTCPSGQIAP----SCGSRSIQHCNIRCMNGG-SCSDDHCLCQKGYIGTHC------- 145

Query: 208 KNQRDCILTCNHGNGGC----QHSCDDTADGPECSCHPQYKMHTDGRS--CLEREDTVL- 260
             Q  C   C +G G C    + +C     GP+C          D R+  C     TV+ 
Sbjct: 146 -GQPVCESGCLNG-GRCVAPNRCACTYGFTGPQCE--------RDYRTGPCF----TVIS 191

Query: 261 -EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGK 319
            ++ +   + +V       + L    CA         C+      H  C  GF   +   
Sbjct: 192 NQMCQGQLSGIV-----CTKTLC---CATVGRAWGHPCEMCPAQPH-PCRRGFIPNIRTG 242

Query: 320 TCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS-LDRTCD-H 376
            C+D+DECQ   G C    C N VGSF+C C  G KL    + C+D+DECS +   C+  
Sbjct: 243 ACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGG 302

Query: 377 SCINHPGTFACACNRG-YTLYGFTHCGDTNE----CSINNGGCQQVCVNTVGSYECQCHP 431
            C N   ++ C C  G YT    T C D        ++ NG C      ++   +C C  
Sbjct: 303 ECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDA 362

Query: 432 G 432
           G
Sbjct: 363 G 363



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 50/155 (32%), Positives = 68/155 (43%), Gaps = 12/155 (7%)

Query: 10  GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSY 69
           G AW     +    P     G +P  R    G  +DVDEC Q +        C NT  S+
Sbjct: 214 GRAWGHPCEMCPAQPHPCRRGFIPNIR---TGACQDVDEC-QAIPGLCQGGNCINTVGSF 269

Query: 70  KCSCKPGYQGE--GRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNC 126
           +C C  G++     ++CEDIDEC   + G C   +C N   +Y C C  GF  + DG  C
Sbjct: 270 ECKCPAGHKLNEVSQKCEDIDECST-IPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328

Query: 127 LDV--DECLE--NNGGCQHTCVNVMGSYECCCKEG 157
           +DV    C     NG C +     +   +CCC  G
Sbjct: 329 IDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAG 363



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 32/87 (36%), Positives = 44/87 (50%), Gaps = 3/87 (3%)

Query: 84  CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-H 141
           C+D+DEC   + G C   +C+N  G++ C C  G  L      C D+DEC    G C+  
Sbjct: 244 CQDVDEC-QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGG 302

Query: 142 TCVNVMGSYECCCKEGFFLSDNQHTCI 168
            C N + SY C C  GF+ S +   CI
Sbjct: 303 ECTNTVSSYFCKCPPGFYTSPDGTRCI 329



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 60/227 (26%), Positives = 89/227 (39%), Gaps = 17/227 (7%)

Query: 288 VNNGGCDRT---CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344
           +N G C      C+    G HC  PV  +  L+G  C   + C    G     C+    +
Sbjct: 124 MNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRT 183

Query: 345 FDCGCKKGFKLLTDEKS---CQDVDECS-LDRTCDHSCINHPGTFACACNRGYTLYGFTH 400
             C      ++   + S   C     C+ + R   H C   P      C RG+     T 
Sbjct: 184 GPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ-PHPCRRGFIPNIRTG 242

Query: 401 -CGDTNECSINNGGCQQV-CVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVS 458
            C D +EC    G CQ   C+NTVGS+EC+C  G+KL+   + C ++      S  P + 
Sbjct: 243 ACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID---ECSTIPGIC 299

Query: 459 LHCGKSGGGDGCFLRCHSGIHLSSDVT---TIRTSVTF-KLNEGKCS 501
                +      F +C  G + S D T    +R    +  L  G+CS
Sbjct: 300 EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCS 346



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 54/203 (26%), Positives = 72/203 (35%), Gaps = 29/203 (14%)

Query: 636  NQCVS----CRAGTYYDGARERCILCPNGTFQNEEGQ----MTCEPCPRPGNSGALKTPE 687
            ++CV     C  GT  +       LCP G   +  G+    +    C      G   +P+
Sbjct: 2015 DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPK 2074

Query: 688  AWNMSECGGLCQ-PGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLAT-KHQGATSF 745
            + N S+    C   GE   D   PC+LC   T   EA R  C P G G+       A   
Sbjct: 2075 SRNHSKQECCCALKGEGWGD---PCELCP--TEPDEAFRQIC-PYGSGIIVGPDDSAVDM 2128

Query: 746  QDCETRVQCSPGHFYNTT-THRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQC 804
             +C+    C  G   NT  ++RC  CP G               GN   D D  +    C
Sbjct: 2129 DECKEPDVCKHGQCINTDGSYRC-ECPFG-----------YILAGNECVDTDECSVGNPC 2176

Query: 805  KNRRCGGELGDFTGYIESPNYPG 827
             N  C   +G F    E    PG
Sbjct: 2177 GNGTCKNVIGGFECTCEEGFEPG 2199



 Score = 37.4 bits (85), Expect = 0.071
 Identities = 62/282 (21%), Positives = 91/282 (32%), Gaps = 59/282 (20%)

Query: 71  CSCKPGYQGEGRQCEDIDECGNE-LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDV 129
           C+C  G          I  C    +NGG   D         C C  G++  H G    + 
Sbjct: 100 CTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD-------HCLCQKGYIGTHCGQPVCE- 151

Query: 130 DECLENNGGCQHTCVNVMGSYECCCKEGF--------------FLSDNQHTCIHRSE--- 172
             CL N G C       +    C C  GF              F   +   C  +     
Sbjct: 152 SGCL-NGGRC-------VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIV 203

Query: 173 --EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQH-S 227
             + L C        H C+  P  +    CR GF        C  +  C    G CQ  +
Sbjct: 204 CTKTLCCATVGRAWGHPCEMCP--AQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGN 261

Query: 228 CDDTADGPECSCHPQYKMHTDGRSCLERED--TVLEVTE----SNTTSVV---------- 271
           C +T    EC C   +K++   + C + ++  T+  + E    +NT S            
Sbjct: 262 CINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYT 321

Query: 272 --DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVG 311
             DG + +  R      A+ NG C      + T + C C  G
Sbjct: 322 SPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAG 363



 Score = 37.4 bits (85), Expect = 0.071
 Identities = 49/165 (29%), Positives = 54/165 (32%), Gaps = 50/165 (30%)

Query: 671  CEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAP------------CQ----LC 714
            CE CP            A N SE   LC  GE    GF P            CQ    LC
Sbjct: 1574 CEMCP------------AVNTSEYKILCPGGE----GFRPNPITVILEDIDECQELPGLC 1617

Query: 715  ALGTFQPEAGRTSC-FPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVG 773
              G      G   C  P G  L    +      +CET   C PG  YNT  +    CP  
Sbjct: 1618 QGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICP-P 1676

Query: 774  TYQPEFGKNNCVS-----CPGNTTTDFDGSTNITQCKNRRCGGEL 813
             Y    G NNC+      C  N   D           N+ C GEL
Sbjct: 1677 DYMQVNGGNNCMDMRRSLCYRNYYAD-----------NQTCDGEL 1710



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 58/255 (22%), Positives = 87/255 (34%), Gaps = 48/255 (18%)

Query: 616  PPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCI---LCPNGTFQNEEGQMTCE 672
            P R +    E C  G G A  +  + +   ++    E  +   LC +G  +N  G   C 
Sbjct: 997  PMRNTPEYEELCPRGPGFATKEITNGKP--FFKDINECKMIPSLCTHGKCRNTIGSFKCR 1054

Query: 673  PCPRPGNSGALKTPEAWNMSE----------CG-GLC--QPGEYSA---DGFAPCQLCAL 716
             C    +SG     E  N ++          CG G C   PG++     +G+    +   
Sbjct: 1055 -C----DSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMK 1109

Query: 717  GTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCI-------- 768
                 +  +     C GG+    +G+        R +C PGH  +     CI        
Sbjct: 1110 NCMDIDECQRDPLLCRGGVCHNTEGSY-------RCECPPGHQLSPNISACIDINECELS 1162

Query: 769  --RCPVGTYQPEFGKNNCVSCPG-NTTTDFDGSTNITQCK--NRRCGGELGDFTGYIESP 823
               CP G      GK  C   PG ++T D     +I +C   N  C     +  G  E  
Sbjct: 1163 AHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECS 1222

Query: 824  NYPG--NYPANTECT 836
              PG    P    CT
Sbjct: 1223 CQPGFALMPDQRSCT 1237



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 38/153 (24%), Positives = 51/153 (33%), Gaps = 34/153 (22%)

Query: 671 CEPCP------RPGNSGALKTPEAWNMSECG---GLCQPGEYSADGFAPCQLCALGTFQP 721
           CE CP      R G    ++T    ++ EC    GLCQ G           +  +G+F+ 
Sbjct: 221 CEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNC---------INTVGSFEC 271

Query: 722 EAGRTSCFPCGGGLATKHQGATSFQDCETRVQ-CSPGHFYNTTTHRCIRCPVGTYQPEFG 780
           +       P G  L    Q      +C T    C  G   NT +    +CP G Y     
Sbjct: 272 KC------PAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY----- 320

Query: 781 KNNCVSCPGNTTTDFDGSTNITQCKNRRCGGEL 813
                S  G    D       T   N RC  +L
Sbjct: 321 ----TSPDGTRCIDVRPGYCYTALTNGRCSNQL 349


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  210 bits (535), Expect = 5e-54
 Identities = 147/473 (31%), Positives = 210/473 (44%), Gaps = 48/473 (10%)

Query: 10   GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGP-------QEDVDECAQGLDDCHADALC 62
            GA W V       P  L  A   P G G A+          +DV+EC      C     C
Sbjct: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC-THGTC 1002

Query: 63   QNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCF----DG 116
            +NT  S+ C+C  G+    + R C DIDEC    +      C+N PG++ C CF     G
Sbjct: 1003 RNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESG 1062

Query: 117  FMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGL 175
            FML     NC+DVDEC  +   C+  TC N  GSY+C C  G  L+     C    E+  
Sbjct: 1063 FMLM---KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC----EDID 1115

Query: 176  SCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTAD 233
             C   D  C H       G+  C C  GF+   +++ C  I  C   NGGC   C +T  
Sbjct: 1116 ECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEG 1175

Query: 234  GPECSCHPQYKMHTDGRSCL---EREDTVLEVTESNTTSVVDGDK-----------RVKR 279
               CSC   Y +  DGR+C    E E+      + + T++  G +            ++ 
Sbjct: 1176 SYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRT 1235

Query: 280  RLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF- 337
             + ++ C +N   C    C++T     C C +G+ ++     C D+DEC+     CD   
Sbjct: 1236 CVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHA 1295

Query: 338  -CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCD--HSCINHPGTFACACNRGY 393
             C NI GSF C C  G+  + D   C D+DEC S +  C     C+N PG++ C C +G+
Sbjct: 1296 SCLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF 1353

Query: 394  TLYGFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
               GF  C D +EC+ N   C    C+N  G Y C+C  G+    + + C +V
Sbjct: 1354 AGDGF-FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDV 1405



 Score =  199 bits (507), Expect = 8e-51
 Identities = 184/662 (27%), Positives = 242/662 (36%), Gaps = 145/662 (21%)

Query: 8    RPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGP---QEDVDECAQGLDDCHADALCQN 64
            RPG  W     L             P G G   GP   +EDV+ECA+    C  + +C N
Sbjct: 2044 RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC-TNGVCVN 2102

Query: 65   TPTSYKCSCKPGYQ--------------------GEGR---------------------- 82
            T  S++C C  GY                     G+G                       
Sbjct: 2103 TDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162

Query: 83   QCEDIDECG-NELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH 141
             CEDIDEC  N L   C   C N  G+Y CTC  G+ L  DG  C DVDEC +    C  
Sbjct: 2163 TCEDIDECSLNPLL--CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2220

Query: 142  T---CVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEA----PRG 194
                C N++G++ C C  G          +  S EG +  N+ H    +C         G
Sbjct: 2221 RGMECKNLIGTFACVCPPGM-------RPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAG 2273

Query: 195  SVACECRPGFELAKNQRDCI------------------------------LTCNHGNGG- 223
            S  C+C  GF+ +    +C                                 C  G G  
Sbjct: 2274 SFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWG 2333

Query: 224  -----------------CQHSCDDTADG---PECSCHPQYKMHTDGRSCLEREDTVLEVT 263
                             C H    TA+G    EC        H +   C+    +     
Sbjct: 2334 PRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE---CINSLGSFRCHC 2390

Query: 264  ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
            ++  T     D      L M+ C+     C   CK+T     CSCP G+ L+ DG+TCKD
Sbjct: 2391 QAGYTP----DATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446

Query: 324  IDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR---TCDHSCIN 380
            +DEC +R   C   C N VG+F C C  GF      ++C D DECS           C N
Sbjct: 2447 LDECTSRQHNCQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHN 2504

Query: 381  HPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNK 439
             PG+F C C++G+TL    H C D NEC      CQ  C N +G Y C C  G+  H   
Sbjct: 2505 TPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQNQLGGYRCSCPQGFTQHSQW 2563

Query: 440  KDCVEVKGLLPTSVSPRV--SLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNE 497
              CV+       ++SP    S  C  + GG  C   C SG      +   +         
Sbjct: 2564 AQCVDEN---ECALSPPTCGSASCRNTLGGFRCV--CPSGFDFDQALGGCQEVDECAGRR 2618

Query: 498  GKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTP-KEMFIT 556
            G CS   A   P G     P+ +      FR     C SG  +  +PG   TP KE  ++
Sbjct: 2619 GPCSYSCANT-PGGFLCGCPQGY------FRAGQGHCVSG--LGFSPGPQDTPDKEELLS 2669

Query: 557  VE 558
             E
Sbjct: 2670 SE 2671



 Score =  192 bits (488), Expect = 1e-48
 Identities = 138/442 (31%), Positives = 186/442 (42%), Gaps = 31/442 (7%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC-GNELNGGCVHDCL 103
            DVDEC  G  +C + A C N P S+ C C PG+ G+G +C D+DEC   E       DCL
Sbjct: 1280 DVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCL 1339

Query: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSD 162
            N+PG+YRCTC  GF  A DG  C D DEC EN   C +  C+N  G Y C C+ GF  ++
Sbjct: 1340 NVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTE 1397

Query: 163  NQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHG 220
            +   C    E    C   +      C+  P G   C C  G+EL +   +C  I  C   
Sbjct: 1398 DHRACQDVDE----CAQGNLCAFGSCENLP-GMFRCICNGGYELDRGGGNCTDINECADP 1452

Query: 221  NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVKR 279
                   C +T     CSC   ++++  G  C++ R       T     S +     +  
Sbjct: 1453 VNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGV 1512

Query: 280  RLLMETCAVNNG-----GCDRTCKDTSTGVHCSCPVGFTLQLDGKT--CKDIDECQTRNG 332
             +   +C  + G      C+      +T     CP G   Q +  T   +DIDECQ   G
Sbjct: 1513 GVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPG 1572

Query: 333  GCD-HFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC--DHSCINHPGTFACAC 389
             C    C N  GSF C C  G+ L    + C+D+DECS         +C N  G + C C
Sbjct: 1573 LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVC 1632

Query: 390  NRGY-TLYGFTHCGDTNECSI---NNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
               Y  + G  +C D  +       NG CQ      V    C C       WN + C   
Sbjct: 1633 PAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN-RPC--- 1688

Query: 446  KGLLPTSVSPRVSLHCGKSGGG 467
                PT +SP   + CG    G
Sbjct: 1689 -EACPTPISPDYQILCGNQAPG 1709



 Score =  191 bits (484), Expect = 4e-48
 Identities = 213/831 (25%), Positives = 307/831 (36%), Gaps = 143/831 (17%)

Query: 51   QGLDDC-HADALCQN-----TPTSYKCSCKPGYQGEGR-QCEDIDECGNELNGGCVH-DC 102
            Q +D C H   LC N     TP+SY+C C  GY  + R +C D+DEC    +  C H DC
Sbjct: 407  QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC---TSSPCHHGDC 463

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMGSYECCCKEGFFLS 161
            +NIPG Y C C+ GF        C+DVDEC+ + G C    CVN  GS++C C  GF LS
Sbjct: 464  VNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELS 523

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
             +   C+  +E   S M  +  C +       GS +C C+PGF LA     C  I  C  
Sbjct: 524  PDGKNCVDHNECATSTMCVNGVCLN-----EDGSFSCLCKPGFLLAPGGHYCMDIDECQT 578

Query: 220  GNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKR 279
                    C +T     C C     + TDGR C++                         
Sbjct: 579  PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH----------------------- 615

Query: 280  RLLMETC--AVNNGGCDRTCKDTSTGVHCSCPV---GFTLQLDGKTCKDIDECQTRNGGC 334
              +  TC  A+  G C R    T T   C C     GF     G+ C+    C  ++   
Sbjct: 616  --VRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-----GEPCQ---LCPAKDSA- 664

Query: 335  DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRG 392
                      F   C  G  + TD +   D++EC+LD   C +  C N  G++ C CN G
Sbjct: 665  ---------EFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLG 712

Query: 393  YTLYGF-THCGDTNECSINNGGCQQV-CVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP 450
            Y        C D +EC++N+  C    C N+ GSY C C PG+    + + C +V   L 
Sbjct: 713  YEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLS 772

Query: 451  TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVT----TIRTSVTFKLNEGKC--SLKN 504
               SP VS  C    G   C  +C  G  L    T    + + +   K+ E +C  +L+ 
Sbjct: 773  ---SPCVSGVCRNLAGSYTC--KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG 827

Query: 505  AELFPE-----GLRPALPEKHSSVKES-----FRYVNLTCSSGKQVPGAPGRPSTPKEMF 554
            A L  E     G     P +   +  +      R   +TC    +    PG     + + 
Sbjct: 828  ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVN 887

Query: 555  ITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQL------SGM 608
                F  E  +  +  +    C+  R E    +            ++ + +      +  
Sbjct: 888  TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW 947

Query: 609  NLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCI---LCPNGTFQNE 665
             ++    P   S   A  C  G G A    +S R   +Y    E  +   LC +GT +N 
Sbjct: 948  GVECEACPDPESLEFASLCPRGLGFASRDFLSGR--PFYKDVNECKVFPGLCTHGTCRNT 1005

Query: 666  EGQMTCEPCPRPGNSGALKTPE--AWNMSEC--------GGLC--QPGEYSAD---GFAP 710
             G   C  C       AL   E    ++ EC         G C   PG +  +   G+  
Sbjct: 1006 VGSFHC-AC---AGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061

Query: 711  CQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCI-- 768
              +        +        C GG  T   G+        + QC PGH        C   
Sbjct: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGS-------YKCQCPPGHELTAKGTACEDI 1114

Query: 769  --------RCPVGTYQPEFGKNNCVSCPG-NTTTDFDGSTNITQCKNRRCG 810
                     CP G      G   C    G  +T D  G  +I +C+ +  G
Sbjct: 1115 DECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG 1165



 Score =  187 bits (475), Expect = 4e-47
 Identities = 143/479 (29%), Positives = 209/479 (43%), Gaps = 40/479 (8%)

Query: 47   DECAQGLDDC-HADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVHDCL 103
            +EC +  + C H D  C +T  SY C C  G+Q    Q  C DIDEC  +  G     C 
Sbjct: 1807 NECREIPNVCSHGD--CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT--CK 1862

Query: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG-CQHT-CVNVMGSYECCCKEGFFLS 161
            NI G+Y C CF GF++ H+G +C+D DEC    G  C+   C+N  GS+ C C++GF L+
Sbjct: 1863 NIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELT 1921

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221
             +   C+  +E    C++    C     +   GS  C C PGF++  +    I  C+   
Sbjct: 1922 ADGKNCVDTNE----CLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEP 1977

Query: 222  GGCQH-SCDDTADGPECSCHPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVKR 279
              C   +C ++    +C C P + +  +G  C + R+       E+   SV       K 
Sbjct: 1978 NLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKT 2037

Query: 280  RLLMETCAVNNGG--CDRTCKDTSTGVHCSCPVGF-TLQLDGKTCKDIDECQTRNGGCDH 336
            R           G  C+   ++ S      CP G   +     + +D++EC    G C +
Sbjct: 2038 RCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTN 2097

Query: 337  -FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYT 394
              C N  GSF C C  G+ L     +C D DECS+   C   +C N  G F CAC  G+ 
Sbjct: 2098 GVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFE 2157

Query: 395  LYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWN-------------KKD 441
                  C D +ECS+N   C   C NT GSY C C  GY L  +             ++D
Sbjct: 2158 PGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217

Query: 442  C----VEVKGLLPTSVSPRVSLHCGKSGGGDGCF--LRCHSGIHLSSDVTTIRTSVTFK 494
            C    +E K L+ T             G G+GC     CH+   L  +   + T+ +F+
Sbjct: 2218 CHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFR 2276



 Score =  186 bits (472), Expect = 9e-47
 Identities = 142/468 (30%), Positives = 189/468 (40%), Gaps = 101/468 (21%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCEDI-----------DEC 90
            +DV+EC      C  +  C NT  S++C C  G      GR C D+           DEC
Sbjct: 868  DDVNECESFPGVC-PNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC 926

Query: 91   GNELNGGCVHDCLNIPGNYR---CTCFDGFMLAHDGHNC--------------------- 126
            G           + +PG YR   C C  G +   +   C                     
Sbjct: 927  G-----------VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASR 975

Query: 127  ---------LDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLS 176
                      DV+EC    G C H TC N +GS+ C C  GF L   +  C    E    
Sbjct: 976  DFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDE---- 1031

Query: 177  CMNKDHGCSH-ICKEAPRGSVACECRPGFE----LAKNQRD---CI---LTCNHGNGGCQ 225
            C      C    C   P GS  CEC PG+E    L KN  D   C    L C  G     
Sbjct: 1032 CRISPDLCGQGTCVNTP-GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGG----- 1085

Query: 226  HSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVL-----------EVTESNTTSVVDGD 274
             +C +T    +C C P +++   G +C + ++  L            V  +   S   G 
Sbjct: 1086 -TCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGF 1144

Query: 275  KRVKRR---LLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331
            +    R   + +  C V NGGCD  C +T     CSC  G++L  DG+ C D+DEC+   
Sbjct: 1145 QSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204

Query: 332  GGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDH-SCINHPGTFACA 388
              CD   C N+ G   C C  GF    D ++C DVDEC L+   C H  C N  G+F C 
Sbjct: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCH 1264

Query: 389  CNRGYTL-YGFTHCGDTNECSINNGGCQQ--VCVNTVGSYECQCHPGY 433
            C  GY +  G T C D +EC +    C     C+N  GS+ C+C PG+
Sbjct: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW 1312



 Score =  178 bits (452), Expect = 2e-44
 Identities = 124/408 (30%), Positives = 176/408 (43%), Gaps = 44/408 (10%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVH-- 100
           DVDEC      CH    C N P +Y C C PG+Q    +  C D+DEC   ++GG  H  
Sbjct: 449 DVDECTSS--PCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDEC--IVSGGLCHLG 503

Query: 101 DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFL 160
            C+N  G+++C C  GF L+ DG NC+D +EC  +       C+N  GS+ C CK GF L
Sbjct: 504 RCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLL 563

Query: 161 SDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI-----L 215
           +   H C+   E    C       +  C     GS  C+C  G  +  + R C+      
Sbjct: 564 APGGHYCMDIDE----CQTPGICVNGHCTNT-EGSFRCQCLGGLAVGTDGRVCVDTHVRS 618

Query: 216 TCNHG--NGGCQHSCDDTADGPECSC-HPQYKMHTDGRSCLEREDTVLEVTESNTTSV-V 271
           TC      G C      T    EC C +P +      + C  ++    +   S+   +  
Sbjct: 619 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITT 678

Query: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331
           DG    +  L  E CA  NG     C++      C C +G+     GK C D+DEC   +
Sbjct: 679 DGRDINECALDPEVCA--NG----VCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732

Query: 332 GGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACN 390
             CD+ +C+N  GS+ C C  GF    D + C+DVDEC         C N  G++ C C 
Sbjct: 733 LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCG 792

Query: 391 RGYTL-YGFTHCGDT-----------NECSINNGGC--QQVCVNTVGS 424
            G  L    T C D+           + C +N  G   +  C  T+G+
Sbjct: 793 PGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840



 Score =  167 bits (422), Expect = 6e-41
 Identities = 134/453 (29%), Positives = 199/453 (43%), Gaps = 58/453 (12%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE--GRQCEDIDECGNELNGGCVHD 101
            +DVDECAQG  +  A   C+N P  ++C C  GY+ +  G  C DI+EC + +N  C++ 
Sbjct: 1403 QDVDECAQG--NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN--CING 1458

Query: 102  -CLNIPGNYRCTCFDGFMLAHDGHNCLDV--DECL---ENNGGCQHTCVNVMG----SYE 151
             C+N PG+Y C+C   F L   G  C+D     C     + G    +C   +G       
Sbjct: 1459 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS 1518

Query: 152  CCCKEGFFLSDNQHTC--IHRSEEGLSCMNKDHGCSHI----------CKEAPR------ 193
            CCC  G    +    C   + +E    C   +    +           C+E P       
Sbjct: 1519 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD 1578

Query: 194  -----GSVACECRPGFELAKNQRDC--ILTCNHGNGGC-QHSCDDTADGPECSCHPQYKM 245
                 GS  CEC PG+ L+++ R C  I  C+  +G C   +C +T     C C  +Y  
Sbjct: 1579 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ 1638

Query: 246  HTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC-DRTCKDTSTGV 304
               G +C++   +V      N T   +    V R++    C+ N G   +R C+   T +
Sbjct: 1639 VNGGNNCMDMRKSVC-FRHYNGTCQNELAFNVTRKMCC--CSYNIGQAWNRPCEACPTPI 1695

Query: 305  HCSCPV-------GFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLL 356
                 +       GF   +      DIDEC      C +  C N +GSF C C  GF   
Sbjct: 1696 SPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN 1755

Query: 357  TDEKSCQDVDEC-SLDRTCDHS--CINHPGTFACACNRGYTLYGFTHCGDTNEC-SINNG 412
            +   +C+DVDEC S +  C  +  CIN PG++ C C RGY L     C   NEC  I N 
Sbjct: 1756 SILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNV 1815

Query: 413  GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
                 C++T GSY C CH G++   ++  C+++
Sbjct: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLCMDI 1848



 Score =  166 bits (421), Expect = 8e-41
 Identities = 129/449 (28%), Positives = 184/449 (40%), Gaps = 83/449 (18%)

Query: 72   SCKPGY-QGEGRQCEDIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDV 129
            +C  G+ +  G  C+D++EC     G C +  C+N  G++RC C +G ML   G  C+DV
Sbjct: 854  ACARGFARMTGVTCDDVNEC-ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV 912

Query: 130  --DECL----ENNGGCQHTCVNVMGSYE---CCCKEGFFLSDNQHTC--------IHRSE 172
              + C     E+  G     V + G Y    CCC  G         C             
Sbjct: 913  RLEPCFLRWDEDECG-----VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCP 967

Query: 173  EGLSCMNKDH------------------GCSHICKEAPRGSVACECRPGFELAKNQRDC- 213
             GL   ++D                    C+H       GS  C C  GF L   +R+C 
Sbjct: 968  RGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCT 1027

Query: 214  -ILTCNHGNGGC-QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
             I  C      C Q +C +T    EC C P Y+                           
Sbjct: 1028 DIDECRISPDLCGQGTCVNTPGSFECECFPGYE--------------------------- 1060

Query: 272  DGDKRVKRRLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTR 330
             G   +K  + ++ CA +   C   TC +T     C CP G  L   G  C+DIDEC   
Sbjct: 1061 SGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLS 1120

Query: 331  NGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR-TCDHSCINHPGTFACA 388
            +G C H  C N++G+F C C  GF+   D + C D++EC +    CD  CIN  G++ C+
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCS 1180

Query: 389  CNRGYTLY-GFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446
            C +GY+L      C D +EC  N   C Q  C N  G + C C+ G+    + + CV+V 
Sbjct: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVD 1240

Query: 447  GLLPTSVSPRVSLHCGKSGGGDGCFLRCH 475
                  ++P + LH G      G F+ CH
Sbjct: 1241 ---ECDLNPHICLH-GDCENTKGSFV-CH 1264



 Score =  166 bits (421), Expect = 8e-41
 Identities = 140/475 (29%), Positives = 190/475 (40%), Gaps = 98/475 (20%)

Query: 23   PPLLLLAGAVPPG--RGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE 80
            P   +L G   PG       G   D+DEC +    C A+ +C N   S++C C  G+   
Sbjct: 1697 PDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYN 1755

Query: 81   G--RQCEDIDECGNELNGGCVH--DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENN 136
                 CED+DECG+     C    DC+NIPG+YRC C  G+ L+  G  C+  +EC E  
Sbjct: 1756 SILLACEDVDECGSR-ESPCQQNADCINIPGSYRCKCTRGYKLS-PGGACVGRNECREIP 1813

Query: 137  GGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGS 195
              C H  C++  GSY C C  GF  S +Q  C+   E    C  +  G +  CK    GS
Sbjct: 1814 NVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDE----CDRQPCG-NGTCKNI-IGS 1867

Query: 196  VACECRPGFELAKNQRDCI----------LTCNHGNGGCQHSCDDTADGPECSCHPQYKM 245
              C C PGF +  N  DC+            C  G+      C +TA    C C   +++
Sbjct: 1868 YNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGH------CLNTAGSFHCLCQDGFEL 1920

Query: 246  HTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVH 305
              DG++C++  + +                      L  TC         TC++      
Sbjct: 1921 TADGKNCVDTNECL---------------------SLAGTCLPG------TCQNLEGSFR 1953

Query: 306  CSCPVGFTLQLDGKTCKDIDECQTRNGGC-DHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
            C CP GF +Q D   C DIDEC      C    C N  GSF C C  GF L  +   C D
Sbjct: 1954 CICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD 2011

Query: 365  -----------VDECSLDRTCDHS-----CINHPG------------------TFACACN 390
                         +CS+ +  + +     C   PG                     C   
Sbjct: 2012 TRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFG 2071

Query: 391  RGYTLYGFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVE 444
             G          D NEC+ N G C   VCVNT GS+ C+C  GY L +   +CV+
Sbjct: 2072 HGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126



 Score =  164 bits (414), Expect = 5e-40
 Identities = 121/413 (29%), Positives = 169/413 (40%), Gaps = 56/413 (13%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLN 104
            D +EC      C     CQN   S++C C PG+Q +   C DIDEC  E N      C N
Sbjct: 1929 DTNECLSLAGTC-LPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTN 1987

Query: 105  IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQ 164
             PG+++C C  GF+L+ +GH C D           Q  C     + +C   + F  +  +
Sbjct: 1988 SPGSFQCLCPPGFVLSDNGHRCFDTR---------QSFCFTRFEAGKCSVPKAFNTTKTR 2038

Query: 165  HTCIHRSEEGLS--C-MNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221
              C  R  EG    C +    G +   +  P G  A    PG     + R+ +  C    
Sbjct: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV---PG---PDDSREDVNECAENP 2092

Query: 222  GGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRR 280
            G C +  C +T     C C   Y +   G +C++ ++                       
Sbjct: 2093 GVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDE----------------------- 2129

Query: 281  LLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKN 340
                 C+V +     TC +   G  C+C  GF   L   TC+DIDEC      C   C N
Sbjct: 2130 -----CSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHN 2183

Query: 341  IVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS----CINHPGTFACACNRGY-TL 395
              GS+ C C  G+ L  D   C+DVDEC+  +   H+    C N  GTFAC C  G   L
Sbjct: 2184 TEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPL 2243

Query: 396  YGFTH-CGDTNECSINNGGC-QQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446
             G    C D NEC      C    CVNT GS+ C C  G++      +C +++
Sbjct: 2244 PGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296



 Score =  139 bits (349), Expect = 2e-32
 Identities = 115/442 (26%), Positives = 169/442 (38%), Gaps = 78/442 (17%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG--EGRQCEDIDECGNELNGGCVHD 101
            ED DECA+ +D C  +  C N P  Y+C C+ G+    + R C+D+DEC    N      
Sbjct: 1361 EDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG-NLCAFGS 1418

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161
            C N+PG +RC C  G+ L   G NC D++EC +        C+N  GSY C C + F L+
Sbjct: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221
             +   C+       +C  + H          RG     C     +   +  C   C+ G 
Sbjct: 1479 PSGVGCV--DTRAGNCFLETH---------DRGDSGISCSAEIGVGVTRASC--CCSLGR 1525

Query: 222  GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281
                      A G  C   P          C   E       + N  +V+  D       
Sbjct: 1526 ----------AWGNPCELCPMANTTEYRTLCPGGEG-----FQPNRITVILED------- 1563

Query: 282  LMETCAVNNGGCD-RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC-DHFCK 339
             ++ C    G C    C +T     C CP G+ L    + C+DIDEC T +G C    C 
Sbjct: 1564 -IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCY 1622

Query: 340  NIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR----TCDHSCINHPGTFACAC------ 389
            N +G++ C C   +  +    +C D+ +    R    TC +    +     C C      
Sbjct: 1623 NTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQ 1682

Query: 390  --NR-----------------GYTLYGF---THCG---DTNECSINNGGCQQ-VCVNTVG 423
              NR                 G    GF    H G   D +EC      C   +C+N +G
Sbjct: 1683 AWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIG 1742

Query: 424  SYECQCHPGYKLHWNKKDCVEV 445
            S+ C+C  G+  +     C +V
Sbjct: 1743 SFRCECPAGFNYNSILLACEDV 1764



 Score =  130 bits (326), Expect = 8e-30
 Identities = 117/437 (26%), Positives = 176/437 (40%), Gaps = 96/437 (21%)

Query: 67   TSYKCSCKPGYQGEGRQ-------CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFM 118
            T Y+  C PG  GEG Q        EDIDEC  EL G C   DC+N  G+++C C  G+ 
Sbjct: 1540 TEYRTLC-PG--GEGFQPNRITVILEDIDEC-QELPGLCQGGDCVNTFGSFQCECPPGYH 1595

Query: 119  LAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSC 177
            L+     C D+DEC  ++G C   TC N +G+Y C C   +   +  + C+   +     
Sbjct: 1596 LSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKS---- 1651

Query: 178  MNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPEC 237
                     +C     G+    C+   ELA N    +  C++  G   +   +    P  
Sbjct: 1652 ---------VCFRHYNGT----CQN--ELAFNVTRKMCCCSYNIGQAWNRPCEACPTP-- 1694

Query: 238  SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
               P Y++      C  +    L  T+ +T   +D D+  +   +   CA  NG     C
Sbjct: 1695 -ISPDYQI-----LCGNQAPGFL--TDIHTGKPLDIDECGE---IPAICA--NG----IC 1737

Query: 298  KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF--CKNIVGSFDCGCKKGFKL 355
             +      C CP GF        C+D+DEC +R   C     C NI GS+ C C +G+KL
Sbjct: 1738 INQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL 1797

Query: 356  L-----------------------------------------TDEKSCQDVDECSLDRTC 374
                                                       D+  C D+DEC      
Sbjct: 1798 SPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCG 1857

Query: 375  DHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQV--CVNTVGSYECQCHPG 432
            + +C N  G++ C C  G+ +     C D +EC+   G   +   C+NT GS+ C C  G
Sbjct: 1858 NGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDG 1917

Query: 433  YKLHWNKKDCVEVKGLL 449
            ++L  + K+CV+    L
Sbjct: 1918 FELTADGKNCVDTNECL 1934



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 65/258 (25%), Positives = 91/258 (35%), Gaps = 44/258 (17%)

Query: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAP--RGSVACECRPGFE-LAKNQ 210
           C EGF    N  TC   +      +++  GCS  C      RG+ +C C+ G+      Q
Sbjct: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGA-SCLCQKGYTGTVCGQ 148

Query: 211 RDCILTCNHGN---GGCQHSCDDTADGPECS-------CHPQYKMHTDGRSCLEREDTVL 260
             C   C++G    G  + +C     GP+C        C  Q      G    + + T L
Sbjct: 149 PICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQV-----GPEGCQHQLTGL 203

Query: 261 EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
             T++   + V         L  E C      C R               GF   +    
Sbjct: 204 VCTKALCCATVGR----AWGLPCELCPAQPHPCRR---------------GFIPNIHTGA 244

Query: 321 CKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVD-----ECSLDRTC 374
           C+D+DECQ   G C    C N+VGSF C C  G +L     +C+D              C
Sbjct: 245 CQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRC 304

Query: 375 DHSCINHPGTFACACNRG 392
                 H     C C+RG
Sbjct: 305 AGDLAGHYTRRQCCCDRG 322



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 53/197 (26%), Positives = 72/197 (36%), Gaps = 45/197 (22%)

Query: 282 LMETCAVNNG-GCDRTCKDTST--GVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFC 338
           L  +C V+ G GC  +C +  T  G  C C  G+T  + G+              CD  C
Sbjct: 108 LAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPI------------CDRGC 155

Query: 339 KN---IVGSFDCGCKKGFKLLTDEKSCQDVDECSLD---RTCDHSCINHPGTFA--CA-- 388
            N    +G   C C  GF     E+  +    C        C H       T A  CA  
Sbjct: 156 HNGGRCIGPNRCACVYGFMGPQCERDYR-TGPCFGQVGPEGCQHQLTGLVCTKALCCATV 214

Query: 389 -----------------CNRGYTLYGFTH-CGDTNECSINNGGCQQ-VCVNTVGSYECQC 429
                            C RG+     T  C D +EC    G CQ   CVN VGS+ C+C
Sbjct: 215 GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRC 274

Query: 430 HPGYKLHWNKKDCVEVK 446
             G++L  +   C + +
Sbjct: 275 PVGHRLSDSSAACEDYR 291



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 24/56 (42%), Positives = 30/56 (53%), Gaps = 1/56 (1%)

Query: 113 CFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTC 167
           C  GF+       C DVDEC    G CQ  +CVN++GS+ C C  G  LSD+   C
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287



 Score = 37.7 bits (86), Expect = 0.054
 Identities = 39/142 (27%), Positives = 48/142 (33%), Gaps = 27/142 (19%)

Query: 640  SCRAGTYYDGA----RERCI----LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNM 691
            +CR G   DG     R+ C     LC NG   N  G   CE                ++ 
Sbjct: 1348 TCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE------------CEMGFDP 1395

Query: 692  SECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQG--ATSFQDCE 749
            +E    CQ  +  A G     LCA G+ +   G   C  C GG      G   T   +C 
Sbjct: 1396 TEDHRACQDVDECAQG----NLCAFGSCENLPGMFRCI-CNGGYELDRGGGNCTDINECA 1450

Query: 750  TRVQCSPGHFYNTTTHRCIRCP 771
              V C  G   NT       CP
Sbjct: 1451 DPVNCINGVCINTPGSYLCSCP 1472



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 84  CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLD--VDECLE--NNGG 138
           C+D+DEC   + G C    C+N+ G++ C C  G  L+     C D     C      G 
Sbjct: 245 CQDVDEC-QAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303

Query: 139 CQHTCVNVMGSYECCCKEG 157
           C           +CCC  G
Sbjct: 304 CAGDLAGHYTRRQCCCDRG 322



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 47/183 (25%), Positives = 62/183 (33%), Gaps = 25/183 (13%)

Query: 656  LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSAD-----GFAP 710
            +C NG   N+ G   CE CP   N  ++      ++ ECG    P + +AD     G   
Sbjct: 1731 ICANGICINQIGSFRCE-CPAGFNYNSILLA-CEDVDECGSRESPCQQNADCINIPGSYR 1788

Query: 711  CQLCALGTFQPEA---GRTSCFP----CGGGLATKHQGATSFQDCETRVQCSPGHFYNTT 763
            C+        P     GR  C      C  G     +G+     C    Q S        
Sbjct: 1789 CKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCL-CHRGFQASADQTLCMD 1847

Query: 764  THRCIR--CPVGTYQPEFGKNNCVSCPGNTTT------DFDGSTNIT--QCKNRRCGGEL 813
               C R  C  GT +   G  NC+  PG   T      DFD  T +    C+   C    
Sbjct: 1848 IDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTA 1907

Query: 814  GDF 816
            G F
Sbjct: 1908 GSF 1910



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 42/178 (23%), Positives = 61/178 (34%), Gaps = 33/178 (18%)

Query: 655  ILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLC 714
            +LC  GT  N +G   C+ CP PG+    K     ++ EC          +DG  P   C
Sbjct: 1080 LLCRGGTCTNTDGSYKCQ-CP-PGHELTAKGTACEDIDECS--------LSDGLCPHGQC 1129

Query: 715  --ALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPV 772
               +G FQ      SC   G       QG     +C  +      H  NT          
Sbjct: 1130 VNVIGAFQ-----CSCH-AGFQSTPDRQGCVDINECRVQNGGCDVHCINTE--------- 1174

Query: 773  GTYQPEFGKNNCVSCPGNTTTDFDG-STNITQCKNRRCGGELGD-----FTGYIESPN 824
            G+Y+   G+   +   G    D D    N   C    C    G      + G++ +P+
Sbjct: 1175 GSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPD 1232



 Score = 33.9 bits (76), Expect = 0.78
 Identities = 47/205 (22%), Positives = 64/205 (31%), Gaps = 45/205 (21%)

Query: 56  CHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFD 115
           C    +   T     C C+ GY G          CG  +     H+     G  RC C  
Sbjct: 120 CSVSCMNGGTCRGASCLCQKGYTGT--------VCGQPICDRGCHNGGRCIGPNRCACVY 171

Query: 116 GFMLAHDGHNC---LDVDECLENNG--GCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHR 170
           GFM    G  C        C    G  GCQH    ++ +   CC             + R
Sbjct: 172 GFM----GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC-----------ATVGR 216

Query: 171 SEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQ-HS 227
           +  GL C         +C   P       CR GF    +   C  +  C    G CQ  S
Sbjct: 217 A-WGLPC--------ELCPAQPH-----PCRRGFIPNIHTGACQDVDECQAVPGLCQGGS 262

Query: 228 CDDTADGPECSCHPQYKMHTDGRSC 252
           C +      C C   +++     +C
Sbjct: 263 CVNMVGSFHCRCPVGHRLSDSSAAC 287



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 46/178 (25%), Positives = 66/178 (37%), Gaps = 34/178 (19%)

Query: 655 ILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSEC------GGLCQ--PGEYSAD 706
           +LC NG  QN  G  +C  CP PG      T    ++ EC       G+C+   G Y+  
Sbjct: 733 LLCDNGWCQNSPGSYSCS-CP-PGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCK 790

Query: 707 GFAPCQLCALGTFQPEAGRTSCF------PCGGGLATKHQGATSFQDCETRVQCSPGHFY 760
                +L   GTF  ++ + +C+       C   L    QGA+   +C   +  + G   
Sbjct: 791 CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNL----QGASLRSECCATLGAAWG--- 843

Query: 761 NTTTHRCIRCPVG-TYQPEFGKNNCVSCPG-NTTTDFDGSTNITQCKNRRCGGELGDF 816
                 C RC +       F +   V+C   N    F G      C N RC    G F
Sbjct: 844 ----SPCERCEIDPACARGFARMTGVTCDDVNECESFPG-----VCPNGRCVNTAGSF 892



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 52/196 (26%), Positives = 72/196 (36%), Gaps = 40/196 (20%)

Query: 656  LCPNGTFQNEEGQMTCEPCPRP---GNSGALKTPE-------AWNMSECGGLCQPGEYSA 705
            +CPNG   N  G   CE CP       SG L            W+  EC G+  PG+Y  
Sbjct: 879  VCPNGRCVNTAGSFRCE-CPEGLMLDASGRLCVDVRLEPCFLRWDEDEC-GVTLPGKYRM 936

Query: 706  DGFAPCQLCALGTFQPEA-------GRTSCFPCGGGLATKH--QGATSFQDCETRVQCSP 756
            D    C + A+   + EA          S  P G G A++    G   ++D     +C  
Sbjct: 937  D-VCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVN---ECKV 992

Query: 757  GHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFD--GSTNITQCK--NRRCG-G 811
              F    TH   R  VG++          +C G    D      T+I +C+     CG G
Sbjct: 993  --FPGLCTHGTCRNTVGSFH--------CACAGGFALDAQERNCTDIDECRISPDLCGQG 1042

Query: 812  ELGDFTGYIESPNYPG 827
               +  G  E   +PG
Sbjct: 1043 TCVNTPGSFECECFPG 1058



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 17/94 (18%)

Query: 693  ECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRV 752
            E  GLCQ G+          +   G+FQ E       P G  L+   +      +C T  
Sbjct: 1569 ELPGLCQGGDC---------VNTFGSFQCEC------PPGYHLSEHTRICEDIDECSTHS 1613

Query: 753  Q-CSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCV 785
              C PG  YNT  +    CP   Y    G NNC+
Sbjct: 1614 GICGPGTCYNTLGNYTCVCP-AEYLQVNGGNNCM 1646



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 41/159 (25%), Positives = 56/159 (35%), Gaps = 28/159 (17%)

Query: 651  RERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAP 710
            RE   +C +G   + EG   C  C R   + A +T    ++ EC                
Sbjct: 1810 REIPNVCSHGDCMDTEGSYMCL-CHRGFQASADQTL-CMDIDECDR-------------- 1853

Query: 711  CQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRV--QCSPGHFYNTTTHRCI 768
             Q C  GT +   G  +C    G + T +     F +C T V   C  GH  NT      
Sbjct: 1854 -QPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHC 1912

Query: 769  RCPVGTYQPEFGK-----NNCVS----CPGNTTTDFDGS 798
             C  G      GK     N C+S    C   T  + +GS
Sbjct: 1913 LCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGS 1951



 Score = 30.4 bits (67), Expect = 8.7
 Identities = 41/161 (25%), Positives = 55/161 (34%), Gaps = 44/161 (27%)

Query: 671  CEPCPRPGNS--------GALKTPEAWNMSEC---GGLCQPGE-YSADGFAPCQLCALGT 718
            CE CP PG S        G+  T E  ++ EC     LC  GE  ++ G   C  C  G 
Sbjct: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCH-CQAG- 2393

Query: 719  FQPEAGRTSCF-------------------------PCGGGLATKHQGAT--SFQDCETR 751
            + P+A  T+C                           C  G   +  G T     +C +R
Sbjct: 2394 YTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSR 2453

Query: 752  VQCSPGHFYNTTTHRCIRCPVG---TYQPEFGKNNCVSCPG 789
                     NT      RCP G    +Q  F  + C + PG
Sbjct: 2454 QHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPG 2494


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  194 bits (493), Expect = 3e-49
 Identities = 127/446 (28%), Positives = 187/446 (41%), Gaps = 45/446 (10%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDC 102
            +++EC    D C A   C N P  Y C C  GY+   + R+C DIDEC    +      C
Sbjct: 874  EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC-CCKEGFFLS 161
             N  G++ C C  GFM + +G NC+DVDECL  +   +  CVN +G++ C  C  G+ ++
Sbjct: 933  ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 992

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221
                    R E+   C+N        C  +P       C  GF     Q   +  C   N
Sbjct: 993  QR-----GRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPN 1047

Query: 222  GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281
                  C +      CSCH  Y    D + C +                           
Sbjct: 1048 VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD--------------------------- 1080

Query: 282  LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341
             ++ C   N   +  CK+T     C+C  G+ L      C+DIDECQ R+      C+N 
Sbjct: 1081 -IDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 1139

Query: 342  VGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT-CDH-SCINHPGTFACACNRGYTLYGFT 399
             GSF C C +G++       C+D++EC  D++ C    CIN  G++ C C  G+ L    
Sbjct: 1140 EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK 1199

Query: 400  HCGDTNECSINNGGC--QQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRV 457
             C D NEC  + G C  Q  C+NT GS+ C C  G+ +  + + C ++   +  +V    
Sbjct: 1200 TCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSH 1258

Query: 458  SLHCGKSGGGDGCFLRCHSGIHLSSD 483
               C  + G   C   C+ G     D
Sbjct: 1259 GF-CDNTAGSFRCL--CYQGFQAPQD 1281



 Score =  180 bits (456), Expect = 7e-45
 Identities = 132/441 (29%), Positives = 190/441 (43%), Gaps = 61/441 (13%)

Query: 41   GPQEDVDECAQGLDDCHADALCQNTPTSYKC-SCKPGYQGEGRQCEDIDECGNELNGGCV 99
            G  ED+DEC      C  D  C N+P SY+C  C  G++G   QC D+DEC  E N    
Sbjct: 995  GRCEDIDECLNP-STC-PDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCAN 1051

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFF 159
             DC N+ G+Y C+C  G+    D  +C D+DEC + N      C N  GS+ C C +G+ 
Sbjct: 1052 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQ 1111

Query: 160  LSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTC 217
            LS  +  C    E+   C ++ H C+H       GS  C C  G+  +     C  I  C
Sbjct: 1112 LSAAKDQC----EDIDECQHR-HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINEC 1166

Query: 218  NHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKR 276
                  CQ   C +TA   +C+C   +++  D ++C +       + E     +      
Sbjct: 1167 LEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQD-------INECEHPGLC----- 1213

Query: 277  VKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH 336
                           G    C +T    HC C  GF++  DG+TC+DIDEC   N  CD 
Sbjct: 1214 ---------------GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDS 1257

Query: 337  --FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS-LDRTCDHS-CINHPGTFACAC--- 389
              FC N  GSF C C +GF+   D + C DV+EC  L   C  + C N  G+F C C   
Sbjct: 1258 HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 1317

Query: 390  NRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLL 449
            N+ Y+         T +C         V V+     + +C      ++N  D      +L
Sbjct: 1318 NQEYSPM-------TGQCRSRTSTDLDVDVDQPKEEKKEC------YYNLNDASLCDNVL 1364

Query: 450  PTSVSPRVSLHCGKSGGGDGC 470
              +V+ +       +G GD C
Sbjct: 1365 APNVTKQECCCTSGAGWGDNC 1385



 Score =  165 bits (418), Expect = 2e-40
 Identities = 118/378 (31%), Positives = 164/378 (43%), Gaps = 28/378 (7%)

Query: 128  DVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
            +++EC  N   C    C+N+   Y C C EG+  S+ Q  C+   E    C    H CS 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDE----CTQVQHLCSQ 929

Query: 187  ICKEAPRGSVACECRPGFELAKNQRDCILT--CNHGNGGCQHSCDDTADGPECS-CHPQY 243
               E   GS  C C  GF  ++   +CI    C   +   +  C +T     C  C   Y
Sbjct: 930  GRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGY 989

Query: 244  KMHTDGR-----SCLER-----EDTVLEVTESNTTSVVDGDKRVKRRLL-METCAVNNGG 292
            +M   GR      CL       E  V            +G +    + L ++ C   N  
Sbjct: 990  RMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVC 1049

Query: 293  CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKG 352
             +  C +      CSC  G+T   D K C+DIDECQ  N   +  CKN  GSF C C +G
Sbjct: 1050 ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQG 1109

Query: 353  FKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGF-THCGDTNECSIN 410
            ++L   +  C+D+DEC     C H  C N  G+F C C++GY   G   HC D NEC  +
Sbjct: 1110 YQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLED 1169

Query: 411  NGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGL-LPTSVSPRVSLHCGKSGGGD 468
               CQ+  C+NT GSY+C C  G++L  N K C ++     P    P+    C  + G  
Sbjct: 1170 KSVCQRGDCINTAGSYDCTCPDGFQLDDN-KTCQDINECEHPGLCGPQG--ECLNTEGSF 1226

Query: 469  GCFLRCHSGIHLSSDVTT 486
             C   C  G  +S+D  T
Sbjct: 1227 HCV--CQQGFSISADGRT 1242



 Score =  155 bits (393), Expect = 1e-37
 Identities = 137/449 (30%), Positives = 194/449 (43%), Gaps = 70/449 (15%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVH-D 101
            D+DEC QG  +   +  C+NT  S++C+C  GYQ      QCEDIDEC +     C H  
Sbjct: 1080 DIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL--CAHGQ 1135

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFL 160
            C N  G+++C C  G+  +  G +C D++ECLE+   CQ   C+N  GSY+C C +GF L
Sbjct: 1136 CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 1195

Query: 161  SDNQHTC--IHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILT 216
             DN+ TC  I+  E    C     G    C     GS  C C+ GF ++ + R C  I  
Sbjct: 1196 DDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDE 1248

Query: 217  CNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGD- 274
            C +      H  CD+TA    C C+  ++   DG+ C++       V E    S V G+ 
Sbjct: 1249 CVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD-------VNECELLSGVCGEA 1301

Query: 275  --KRVKRRLLMETCAVNN-------GGC-DRTCKDTSTGV--------HCSCPVGFTLQL 316
              + V+   L   CA  N       G C  RT  D    V         C   +      
Sbjct: 1302 FCENVEGSFLC-VCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1360

Query: 317  DGKTCKDIDE---CQTRNGG----CDHFCKNIVGSFD----CGCKKGFKLLTDEKS---- 361
            D     ++ +   C T   G    C+ F   ++G+ +    C   KGF    +  S    
Sbjct: 1361 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1420

Query: 362  --CQDVDECSL--DRTCDHS-CINHPGTFACACNRGYTLYGFT--HCGDTNECSINNGGC 414
               +D DEC L     C +  C+N    + C C +G T Y      C D +EC   +   
Sbjct: 1421 ENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSSCI 1479

Query: 415  QQVCVNTVGSYECQCHPGYKLHWNKKDCV 443
               CVNT GSY C C     L  ++K C+
Sbjct: 1480 DGQCVNTEGSYNCFCTHPMVLDASEKRCI 1508



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 119/510 (23%), Positives = 174/510 (34%), Gaps = 134/510 (26%)

Query: 44   EDVDECAQ-GLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVH 100
            +D++EC   GL  C     C NT  S+ C C+ G+    +GR CEDIDEC N        
Sbjct: 1202 QDINECEHPGL--CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG 1259

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCL--------------------------------- 127
             C N  G++RC C+ GF    DG  C+                                 
Sbjct: 1260 FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQ 1319

Query: 128  -------------------DVDECLENNGGCQHT------CVNVMG----SYECCCKEGF 158
                               DVD+  E    C +       C NV+       ECCC  G 
Sbjct: 1320 EYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA 1379

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCN 218
               DN   C       L        C       P G  + E   G E  K+  +C+L   
Sbjct: 1380 GWGDN---CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEA--GGENYKDADECLL--- 1431

Query: 219  HGNGGCQHS-CDDTADGPEC-------------------------SCHPQYKMHTDGR-S 251
             G   C++  C +T  G EC                         SC     ++T+G  +
Sbjct: 1432 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1491

Query: 252  CLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTG-----VHC 306
            C      VL+ +E       + +++++   + +     +   +  C     G       C
Sbjct: 1492 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1551

Query: 307  SCPVGFTLQLDGKTC--KDIDE-CQTRN----GGCDHFCKNIVGSFDCGCKKGFKLLTDE 359
             C  G    +    C  KD D+  Q  N    G    + ++ +  F     + +    D 
Sbjct: 1552 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFS----EQYTPEADP 1607

Query: 360  KSCQD----------VDECSLDRTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNEC 407
               QD           +EC +   C++  C+     + C C  GY L      C D NEC
Sbjct: 1608 YFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1667

Query: 408  S-INN--GGCQQV-CVNTVGSYECQCHPGY 433
              +NN    C+   C+NT GSY+C C PGY
Sbjct: 1668 DELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 91/368 (24%), Positives = 124/368 (33%), Gaps = 69/368 (18%)

Query: 42   PQEDVDECAQGLDDCHADALCQNT----PTSYKCSCKPGYQGEGRQCE------------ 85
            P+E+  EC   L+D    +LC N      T  +C C  G  G G  CE            
Sbjct: 1343 PKEEKKECYYNLNDA---SLCDNVLAPNVTKQECCCTSG-AGWGDNCEIFPCPVLGTAEF 1398

Query: 86   --------------------------DIDEC---GNELNGGCVHD-CLNIPGNYRCTCFD 115
                                      D DEC   G E+   C +  CLN    Y C C  
Sbjct: 1399 TEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEI---CKNGFCLNTRPGYECYCKQ 1455

Query: 116  GFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGL 175
            G         C D+DEC + +      CVN  GSY C C     L  ++  CI  +E   
Sbjct: 1456 GTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1515

Query: 176  SCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNG-GCQHSCDDTADG 234
                 D     +C E       C  RP         +C   C +G   G Q +     D 
Sbjct: 1516 QIEETD-VYQDLCWEHLSDEYVCS-RPLVGKQTTYTEC--CCLYGEAWGMQCALCPLKDS 1571

Query: 235  PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS-----VVDGDKRVKRRLLMETCAVN 289
             + +      +   GR      D +++ +E  T       + D        L  E C + 
Sbjct: 1572 DDYA--QLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGIL 1629

Query: 290  NGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG---CDHF-CKNIVGSF 345
            NG  +  C     G  C C  G+ L     TC D++EC   N     C +  C N  GS+
Sbjct: 1630 NGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSY 1689

Query: 346  DCGCKKGF 353
             C C  G+
Sbjct: 1690 KCLCLPGY 1697



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 33/84 (39%), Positives = 45/84 (53%), Gaps = 5/84 (5%)

Query: 88   DECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQHT-C 143
            +ECG  LNG     C+ +   Y C CFDG+ L      C+DV+EC E N     C++  C
Sbjct: 1624 EECGI-LNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1682

Query: 144  VNVMGSYECCCKEGFFLSDNQHTC 167
            +N  GSY+C C  G+  SD  + C
Sbjct: 1683 INTDGSYKCLCLPGYVPSDKPNYC 1706



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 108/464 (23%), Positives = 157/464 (33%), Gaps = 80/464 (17%)

Query: 364  DVDECSL--DRTCDHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQV-CV 419
            +++EC++  D      CIN P  + C C  GY        C D +EC+     C Q  C 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 420  NTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIH 479
            NT GS+ C C  G+       +C++V   L   V      HC  + G   C   C SG  
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEG--HCVNTVGAFRCEY-CDSGYR 990

Query: 480  LSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQ 539
            ++                G+C     E   E L P+       V     Y  + C+ G +
Sbjct: 991  MTQ--------------RGRC-----EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR 1031

Query: 540  VPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVH-R 598
              G  G+        + V+  LE N   V A+ D S +         K         H R
Sbjct: 1032 --GWNGQ-------CLDVDECLEPN---VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 1079

Query: 599  EQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGH----AENQCVSCRAGTYYDGARERC 654
            +    Q   + ++   K    S R    C  GQG+    A++QC         D  + R 
Sbjct: 1080 DIDECQQGNLCVNGQCKNTEGSFR----CTCGQGYQLSAAKDQCEDI------DECQHRH 1129

Query: 655  ILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLC 714
             LC +G  +N EG   C               + +  S  G  C+      +  + CQ  
Sbjct: 1130 -LCAHGQCRNTEGSFQC------------VCDQGYRASGLGDHCEDINECLEDKSVCQ-- 1174

Query: 715  ALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP-GHFYNTTTHRCIRCPVG 773
              G     AG   C    G     ++      +CE    C P G   NT          G
Sbjct: 1175 -RGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTE---------G 1224

Query: 774  TYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRR-CGGELGDF 816
            ++     +   +S  G T  D D   N T C +   C    G F
Sbjct: 1225 SFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 1268



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 121/557 (21%), Positives = 181/557 (32%), Gaps = 143/557 (25%)

Query: 349  CKKGFKLLTDEKSCQDVDECSLDRTCDHS-CINHPGTFACACNRGY-TLYGFTHC-GDTN 405
            C  G+K + +   CQD++EC L   C +  C+N  G++ C C  G+     F+ C  D  
Sbjct: 612  CLPGYKRVNNT-FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670

Query: 406  ECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSG 465
              S   G C ++      S   QC     +H  K+ C         SV      HC K  
Sbjct: 671  VISEEKGPCYRLV-----SSGRQCMHPLSVHLTKQLCC-------CSVGKAWGPHCEKCP 718

Query: 466  -GGDGCFLR-CHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLR---PALPEKH 520
              G   F   C  G+  +      R  +   + +G   +K     P       P LP K 
Sbjct: 719  LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKE 778

Query: 521  SSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKR 580
              V E+  +      S +  PG     + P+      E E+ +  +E T        ++ 
Sbjct: 779  EPV-EALTF------SREHGPGV----AEPEVATAPPEKEIPSLDQEKTK-------LEP 820

Query: 581  TEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKP------PRTSERQA---------- 624
             + +L   I T+         H Q  G+ ++    P      P  S   A          
Sbjct: 821  GQPQLSPGISTI-------HLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVT 873

Query: 625  --ESCGV-----GQGHAEN-----QCVSCRAGTYYDGARERCI----------LCPNGTF 662
                C V     G GH  N      C+ C  G  +   + +C+          LC  G  
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCI-CYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932

Query: 663  QNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPE 722
            +N EG   C  CP    +G + + E  N  +     +P            +C  G     
Sbjct: 933  ENTEGSFLC-ICP----AGFMASEEGTNCIDVDECLRP-----------DVCGEGHCVNT 976

Query: 723  AGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTT---HRCIRCPVGTYQPEF 779
             G   C  C  G     +G      CE   +C      N +T    +C+  P G+YQ   
Sbjct: 977  VGAFRCEYCDSGYRMTQRGR-----CEDIDEC-----LNPSTCPDEQCVNSP-GSYQ--- 1022

Query: 780  GKNNCVSCP------GNTTTDFDGSTNITQCKNRRCGGELGDF-----TGYIESPNY--- 825
                CV C            D D       C N  C    G +      GY  +P++   
Sbjct: 1023 ----CVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC 1078

Query: 826  -------PGNYPANTEC 835
                    GN   N +C
Sbjct: 1079 RDIDECQQGNLCVNGQC 1095



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/98 (31%), Positives = 42/98 (42%), Gaps = 15/98 (15%)

Query: 73  CKPGYQGEGRQ-CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVD 130
           C PGY+      C+DI+EC  +L G C + +CLN  G+YRCTC  GF       +C+   
Sbjct: 612 CLPGYKRVNNTFCQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 669

Query: 131 ECLENNGG-----------CQHTCVNVMGSYECCCKEG 157
             +    G           C H     +    CCC  G
Sbjct: 670 PVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 707



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 9/93 (9%)

Query: 47   DECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGG---CVH- 100
            +EC   L+ C  +  C      Y C C  GY  +  +  C D++EC +ELN     C + 
Sbjct: 1624 EECGI-LNGCE-NGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC-DELNNRMSLCKNA 1680

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
             C+N  G+Y+C C  G++ +   + C  ++  L
Sbjct: 1681 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 17/87 (19%)

Query: 108 NYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGF-------- 158
           N    C  G+   ++   C D++EC +  G C +  C+N MGSY C CK GF        
Sbjct: 607 NQMMECLPGYKRVNNTF-CQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSS 664

Query: 159 ------FLSDNQHTCIHRSEEGLSCMN 179
                  +S+ +  C      G  CM+
Sbjct: 665 CVPDPPVISEEKGPCYRLVSSGRQCMH 691



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 26/84 (30%), Positives = 35/84 (41%), Gaps = 12/84 (14%)

Query: 321 CKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC--------QDVDEC---- 368
           C+DI+ECQ +    +  C N +GS+ C CK GF       SC        ++   C    
Sbjct: 624 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 683

Query: 369 SLDRTCDHSCINHPGTFACACNRG 392
           S  R C H    H     C C+ G
Sbjct: 684 SSGRQCMHPLSVHLTKQLCCCSVG 707


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  194 bits (493), Expect = 3e-49
 Identities = 127/446 (28%), Positives = 187/446 (41%), Gaps = 45/446 (10%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDC 102
           +++EC    D C A   C N P  Y C C  GY+   + R+C DIDEC    +      C
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC-CCKEGFFLS 161
            N  G++ C C  GFM + +G NC+DVDECL  +   +  CVN +G++ C  C  G+ ++
Sbjct: 607 ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 666

Query: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221
                   R E+   C+N        C  +P       C  GF     Q   +  C   N
Sbjct: 667 QR-----GRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPN 721

Query: 222 GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281
                 C +      CSCH  Y    D + C +                           
Sbjct: 722 VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD--------------------------- 754

Query: 282 LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341
            ++ C   N   +  CK+T     C+C  G+ L      C+DIDECQ R+      C+N 
Sbjct: 755 -IDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 813

Query: 342 VGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT-CDH-SCINHPGTFACACNRGYTLYGFT 399
            GSF C C +G++       C+D++EC  D++ C    CIN  G++ C C  G+ L    
Sbjct: 814 EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK 873

Query: 400 HCGDTNECSINNGGC--QQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRV 457
            C D NEC  + G C  Q  C+NT GS+ C C  G+ +  + + C ++   +  +V    
Sbjct: 874 TCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSH 932

Query: 458 SLHCGKSGGGDGCFLRCHSGIHLSSD 483
              C  + G   C   C+ G     D
Sbjct: 933 GF-CDNTAGSFRCL--CYQGFQAPQD 955



 Score =  180 bits (456), Expect = 7e-45
 Identities = 132/441 (29%), Positives = 190/441 (43%), Gaps = 61/441 (13%)

Query: 41   GPQEDVDECAQGLDDCHADALCQNTPTSYKC-SCKPGYQGEGRQCEDIDECGNELNGGCV 99
            G  ED+DEC      C  D  C N+P SY+C  C  G++G   QC D+DEC  E N    
Sbjct: 669  GRCEDIDECLNP-STC-PDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNVCAN 725

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFF 159
             DC N+ G+Y C+C  G+    D  +C D+DEC + N      C N  GS+ C C +G+ 
Sbjct: 726  GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQ 785

Query: 160  LSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTC 217
            LS  +  C    E+   C ++ H C+H       GS  C C  G+  +     C  I  C
Sbjct: 786  LSAAKDQC----EDIDECQHR-HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINEC 840

Query: 218  NHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKR 276
                  CQ   C +TA   +C+C   +++  D ++C +       + E     +      
Sbjct: 841  LEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQD-------INECEHPGLC----- 887

Query: 277  VKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH 336
                           G    C +T    HC C  GF++  DG+TC+DIDEC   N  CD 
Sbjct: 888  ---------------GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDS 931

Query: 337  --FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS-LDRTCDHS-CINHPGTFACAC--- 389
              FC N  GSF C C +GF+   D + C DV+EC  L   C  + C N  G+F C C   
Sbjct: 932  HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 991

Query: 390  NRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLL 449
            N+ Y+         T +C         V V+     + +C      ++N  D      +L
Sbjct: 992  NQEYSPM-------TGQCRSRTSTDLDVDVDQPKEEKKEC------YYNLNDASLCDNVL 1038

Query: 450  PTSVSPRVSLHCGKSGGGDGC 470
              +V+ +       +G GD C
Sbjct: 1039 APNVTKQECCCTSGAGWGDNC 1059



 Score =  165 bits (418), Expect = 2e-40
 Identities = 118/378 (31%), Positives = 164/378 (43%), Gaps = 28/378 (7%)

Query: 128 DVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
           +++EC  N   C    C+N+   Y C C EG+  S+ Q  C+   E    C    H CS 
Sbjct: 548 EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDE----CTQVQHLCSQ 603

Query: 187 ICKEAPRGSVACECRPGFELAKNQRDCILT--CNHGNGGCQHSCDDTADGPECS-CHPQY 243
              E   GS  C C  GF  ++   +CI    C   +   +  C +T     C  C   Y
Sbjct: 604 GRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGY 663

Query: 244 KMHTDGR-----SCLER-----EDTVLEVTESNTTSVVDGDKRVKRRLL-METCAVNNGG 292
           +M   GR      CL       E  V            +G +    + L ++ C   N  
Sbjct: 664 RMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVC 723

Query: 293 CDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKG 352
            +  C +      CSC  G+T   D K C+DIDECQ  N   +  CKN  GSF C C +G
Sbjct: 724 ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQG 783

Query: 353 FKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGF-THCGDTNECSIN 410
           ++L   +  C+D+DEC     C H  C N  G+F C C++GY   G   HC D NEC  +
Sbjct: 784 YQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLED 843

Query: 411 NGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGL-LPTSVSPRVSLHCGKSGGGD 468
              CQ+  C+NT GSY+C C  G++L  N K C ++     P    P+    C  + G  
Sbjct: 844 KSVCQRGDCINTAGSYDCTCPDGFQLDDN-KTCQDINECEHPGLCGPQG--ECLNTEGSF 900

Query: 469 GCFLRCHSGIHLSSDVTT 486
            C   C  G  +S+D  T
Sbjct: 901 HCV--CQQGFSISADGRT 916



 Score =  155 bits (393), Expect = 1e-37
 Identities = 137/449 (30%), Positives = 194/449 (43%), Gaps = 70/449 (15%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVH-D 101
            D+DEC QG  +   +  C+NT  S++C+C  GYQ      QCEDIDEC +     C H  
Sbjct: 754  DIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL--CAHGQ 809

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFL 160
            C N  G+++C C  G+  +  G +C D++ECLE+   CQ   C+N  GSY+C C +GF L
Sbjct: 810  CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 869

Query: 161  SDNQHTC--IHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILT 216
             DN+ TC  I+  E    C     G    C     GS  C C+ GF ++ + R C  I  
Sbjct: 870  DDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCEDIDE 922

Query: 217  CNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGD- 274
            C +      H  CD+TA    C C+  ++   DG+ C++       V E    S V G+ 
Sbjct: 923  CVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD-------VNECELLSGVCGEA 975

Query: 275  --KRVKRRLLMETCAVNN-------GGC-DRTCKDTSTGV--------HCSCPVGFTLQL 316
              + V+   L   CA  N       G C  RT  D    V         C   +      
Sbjct: 976  FCENVEGSFLC-VCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1034

Query: 317  DGKTCKDIDE---CQTRNGG----CDHFCKNIVGSFD----CGCKKGFKLLTDEKS---- 361
            D     ++ +   C T   G    C+ F   ++G+ +    C   KGF    +  S    
Sbjct: 1035 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1094

Query: 362  --CQDVDECSL--DRTCDHS-CINHPGTFACACNRGYTLYGFT--HCGDTNECSINNGGC 414
               +D DEC L     C +  C+N    + C C +G T Y      C D +EC   +   
Sbjct: 1095 ENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSSCI 1153

Query: 415  QQVCVNTVGSYECQCHPGYKLHWNKKDCV 443
               CVNT GSY C C     L  ++K C+
Sbjct: 1154 DGQCVNTEGSYNCFCTHPMVLDASEKRCI 1182



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 119/510 (23%), Positives = 174/510 (34%), Gaps = 134/510 (26%)

Query: 44   EDVDECAQ-GLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVH 100
            +D++EC   GL  C     C NT  S+ C C+ G+    +GR CEDIDEC N        
Sbjct: 876  QDINECEHPGL--CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG 933

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCL--------------------------------- 127
             C N  G++RC C+ GF    DG  C+                                 
Sbjct: 934  FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQ 993

Query: 128  -------------------DVDECLENNGGCQHT------CVNVMG----SYECCCKEGF 158
                               DVD+  E    C +       C NV+       ECCC  G 
Sbjct: 994  EYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA 1053

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCN 218
               DN   C       L        C       P G  + E   G E  K+  +C+L   
Sbjct: 1054 GWGDN---CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEA--GGENYKDADECLL--- 1105

Query: 219  HGNGGCQHS-CDDTADGPEC-------------------------SCHPQYKMHTDGR-S 251
             G   C++  C +T  G EC                         SC     ++T+G  +
Sbjct: 1106 FGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYN 1165

Query: 252  CLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTG-----VHC 306
            C      VL+ +E       + +++++   + +     +   +  C     G       C
Sbjct: 1166 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1225

Query: 307  SCPVGFTLQLDGKTC--KDIDE-CQTRN----GGCDHFCKNIVGSFDCGCKKGFKLLTDE 359
             C  G    +    C  KD D+  Q  N    G    + ++ +  F     + +    D 
Sbjct: 1226 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFS----EQYTPEADP 1281

Query: 360  KSCQD----------VDECSLDRTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNEC 407
               QD           +EC +   C++  C+     + C C  GY L      C D NEC
Sbjct: 1282 YFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1341

Query: 408  S-INN--GGCQQV-CVNTVGSYECQCHPGY 433
              +NN    C+   C+NT GSY+C C PGY
Sbjct: 1342 DELNNRMSLCKNAKCINTDGSYKCLCLPGY 1371



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 91/368 (24%), Positives = 124/368 (33%), Gaps = 69/368 (18%)

Query: 42   PQEDVDECAQGLDDCHADALCQNT----PTSYKCSCKPGYQGEGRQCE------------ 85
            P+E+  EC   L+D    +LC N      T  +C C  G  G G  CE            
Sbjct: 1017 PKEEKKECYYNLNDA---SLCDNVLAPNVTKQECCCTSG-AGWGDNCEIFPCPVLGTAEF 1072

Query: 86   --------------------------DIDEC---GNELNGGCVHD-CLNIPGNYRCTCFD 115
                                      D DEC   G E+   C +  CLN    Y C C  
Sbjct: 1073 TEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEI---CKNGFCLNTRPGYECYCKQ 1129

Query: 116  GFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGL 175
            G         C D+DEC + +      CVN  GSY C C     L  ++  CI  +E   
Sbjct: 1130 GTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1189

Query: 176  SCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNG-GCQHSCDDTADG 234
                 D     +C E       C  RP         +C   C +G   G Q +     D 
Sbjct: 1190 QIEETD-VYQDLCWEHLSDEYVCS-RPLVGKQTTYTEC--CCLYGEAWGMQCALCPLKDS 1245

Query: 235  PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS-----VVDGDKRVKRRLLMETCAVN 289
             + +      +   GR      D +++ +E  T       + D        L  E C + 
Sbjct: 1246 DDYA--QLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGIL 1303

Query: 290  NGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG---CDHF-CKNIVGSF 345
            NG  +  C     G  C C  G+ L     TC D++EC   N     C +  C N  GS+
Sbjct: 1304 NGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSY 1363

Query: 346  DCGCKKGF 353
             C C  G+
Sbjct: 1364 KCLCLPGY 1371



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 33/84 (39%), Positives = 45/84 (53%), Gaps = 5/84 (5%)

Query: 88   DECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQHT-C 143
            +ECG  LNG     C+ +   Y C CFDG+ L      C+DV+EC E N     C++  C
Sbjct: 1298 EECGI-LNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1356

Query: 144  VNVMGSYECCCKEGFFLSDNQHTC 167
            +N  GSY+C C  G+  SD  + C
Sbjct: 1357 INTDGSYKCLCLPGYVPSDKPNYC 1380



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 108/464 (23%), Positives = 157/464 (33%), Gaps = 80/464 (17%)

Query: 364 DVDECSL--DRTCDHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQV-CV 419
           +++EC++  D      CIN P  + C C  GY        C D +EC+     C Q  C 
Sbjct: 548 EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 420 NTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIH 479
           NT GS+ C C  G+       +C++V   L   V      HC  + G   C   C SG  
Sbjct: 608 NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEG--HCVNTVGAFRCEY-CDSGYR 664

Query: 480 LSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQ 539
           ++                G+C     E   E L P+       V     Y  + C+ G +
Sbjct: 665 MTQ--------------RGRC-----EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR 705

Query: 540 VPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVH-R 598
             G  G+        + V+  LE N   V A+ D S +         K         H R
Sbjct: 706 --GWNGQ-------CLDVDECLEPN---VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 753

Query: 599 EQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGH----AENQCVSCRAGTYYDGARERC 654
           +    Q   + ++   K    S R    C  GQG+    A++QC         D  + R 
Sbjct: 754 DIDECQQGNLCVNGQCKNTEGSFR----CTCGQGYQLSAAKDQCEDI------DECQHRH 803

Query: 655 ILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLC 714
            LC +G  +N EG   C               + +  S  G  C+      +  + CQ  
Sbjct: 804 -LCAHGQCRNTEGSFQC------------VCDQGYRASGLGDHCEDINECLEDKSVCQ-- 848

Query: 715 ALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP-GHFYNTTTHRCIRCPVG 773
             G     AG   C    G     ++      +CE    C P G   NT          G
Sbjct: 849 -RGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTE---------G 898

Query: 774 TYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRR-CGGELGDF 816
           ++     +   +S  G T  D D   N T C +   C    G F
Sbjct: 899 SFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 942



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 121/557 (21%), Positives = 181/557 (32%), Gaps = 143/557 (25%)

Query: 349 CKKGFKLLTDEKSCQDVDECSLDRTCDHS-CINHPGTFACACNRGY-TLYGFTHC-GDTN 405
           C  G+K + +   CQD++EC L   C +  C+N  G++ C C  G+     F+ C  D  
Sbjct: 286 CLPGYKRVNNT-FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344

Query: 406 ECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSG 465
             S   G C ++      S   QC     +H  K+ C         SV      HC K  
Sbjct: 345 VISEEKGPCYRLV-----SSGRQCMHPLSVHLTKQLCC-------CSVGKAWGPHCEKCP 392

Query: 466 -GGDGCFLR-CHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLR---PALPEKH 520
             G   F   C  G+  +      R  +   + +G   +K     P       P LP K 
Sbjct: 393 LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKE 452

Query: 521 SSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKR 580
             V E+  +      S +  PG     + P+      E E+ +  +E T        ++ 
Sbjct: 453 EPV-EALTF------SREHGPGV----AEPEVATAPPEKEIPSLDQEKTK-------LEP 494

Query: 581 TEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKP------PRTSERQA---------- 624
            + +L   I T+         H Q  G+ ++    P      P  S   A          
Sbjct: 495 GQPQLSPGISTI-------HLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVT 547

Query: 625 --ESCGV-----GQGHAEN-----QCVSCRAGTYYDGARERCI----------LCPNGTF 662
               C V     G GH  N      C+ C  G  +   + +C+          LC  G  
Sbjct: 548 EINECTVNPDICGAGHCINLPVRYTCI-CYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606

Query: 663 QNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPE 722
           +N EG   C  CP    +G + + E  N  +     +P            +C  G     
Sbjct: 607 ENTEGSFLC-ICP----AGFMASEEGTNCIDVDECLRP-----------DVCGEGHCVNT 650

Query: 723 AGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTT---HRCIRCPVGTYQPEF 779
            G   C  C  G     +G      CE   +C      N +T    +C+  P G+YQ   
Sbjct: 651 VGAFRCEYCDSGYRMTQRGR-----CEDIDEC-----LNPSTCPDEQCVNSP-GSYQ--- 696

Query: 780 GKNNCVSCP------GNTTTDFDGSTNITQCKNRRCGGELGDF-----TGYIESPNY--- 825
               CV C            D D       C N  C    G +      GY  +P++   
Sbjct: 697 ----CVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC 752

Query: 826 -------PGNYPANTEC 835
                   GN   N +C
Sbjct: 753 RDIDECQQGNLCVNGQC 769



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/98 (31%), Positives = 42/98 (42%), Gaps = 15/98 (15%)

Query: 73  CKPGYQGEGRQ-CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVD 130
           C PGY+      C+DI+EC  +L G C + +CLN  G+YRCTC  GF       +C+   
Sbjct: 286 CLPGYKRVNNTFCQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 343

Query: 131 ECLENNGG-----------CQHTCVNVMGSYECCCKEG 157
             +    G           C H     +    CCC  G
Sbjct: 344 PVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 381



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 9/93 (9%)

Query: 47   DECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGG---CVH- 100
            +EC   L+ C  +  C      Y C C  GY  +  +  C D++EC +ELN     C + 
Sbjct: 1298 EECGI-LNGCE-NGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC-DELNNRMSLCKNA 1354

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECL 133
             C+N  G+Y+C C  G++ +   + C  ++  L
Sbjct: 1355 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 17/87 (19%)

Query: 108 NYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGF-------- 158
           N    C  G+   ++   C D++EC +  G C +  C+N MGSY C CK GF        
Sbjct: 281 NQMMECLPGYKRVNNTF-CQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSS 338

Query: 159 ------FLSDNQHTCIHRSEEGLSCMN 179
                  +S+ +  C      G  CM+
Sbjct: 339 CVPDPPVISEEKGPCYRLVSSGRQCMH 365



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 26/84 (30%), Positives = 35/84 (41%), Gaps = 12/84 (14%)

Query: 321 CKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC--------QDVDEC---- 368
           C+DI+ECQ +    +  C N +GS+ C CK GF       SC        ++   C    
Sbjct: 298 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 357

Query: 369 SLDRTCDHSCINHPGTFACACNRG 392
           S  R C H    H     C C+ G
Sbjct: 358 SSGRQCMHPLSVHLTKQLCCCSVG 381


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  187 bits (474), Expect = 6e-47
 Identities = 133/451 (29%), Positives = 194/451 (43%), Gaps = 55/451 (12%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGY----QGEGRQCEDIDECGNELNGGCVH 100
            D +EC +  D C     C N   SY C C PGY     G  ++C+DI+EC  E  G C  
Sbjct: 887  DDNECLR--DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINEC--EQPGVCSG 942

Query: 101  -DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC-CCKEGF 158
              C N  G+Y C C  G+++   GH C D++EC          CVN  GSY C  C+EG+
Sbjct: 943  GQCTNTEGSYHCECDQGYIMVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY 1001

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILT 216
                   +C+  +E    C+     C+H       GS  C C  G+E+  +++ C  +  
Sbjct: 1002 --RGQSGSCVDVNE----CLTPGV-CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDE 1054

Query: 217  CNHGNGGCQHSCDDTADGPECS-CHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDK 275
            C          C +T     CS C   Y ++ DG +C   ED                  
Sbjct: 1055 CASRASCPTGLCLNTEGSFACSACENGYWVNEDGTAC---ED------------------ 1093

Query: 276  RVKRRLLMETCAVNNGGCDRTCKDTSTGVHCS-CPVGFTLQLDGKTCKDIDECQTRNGGC 334
                   ++ CA         C +T+    C  C  G+     G +C+D+DEC+     C
Sbjct: 1094 -------LDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC 1146

Query: 335  -DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC--DHSCINHPGTFACACNR 391
                CKN VGS+ C C +GF+L  +   C+DV+EC  +  C     C+N  G+F C C  
Sbjct: 1147 LGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAP 1205

Query: 392  GY-TLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP 450
            G+ +  G T C D +EC+  +      CVNT GS+ C C  G++      +CV++     
Sbjct: 1206 GFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECED 1265

Query: 451  TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
                   +  C  S G   C L C  G H++
Sbjct: 1266 YGDPVCGTWKCENSPGSYRCVLGCQPGFHMA 1296



 Score =  171 bits (434), Expect = 2e-42
 Identities = 121/418 (28%), Positives = 183/418 (43%), Gaps = 50/418 (11%)

Query: 41   GPQEDVDECAQGLDDCHADALCQNTPTSYKC-SCKPGYQGEGRQCEDIDECGNELNGGCV 99
            G  +D++EC      C  D  C N+P SY C +C+ GY+G+   C D++EC     G C 
Sbjct: 966  GHCQDINECRHP-GTC-PDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTP--GVCA 1021

Query: 100  HD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC-CCKEG 157
            H  C N+ G++RC+C  G+ +  D   C DVDEC          C+N  GS+ C  C+ G
Sbjct: 1022 HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENG 1081

Query: 158  FFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVAC-ECRPGFELAKNQRDC--I 214
            ++++++   C    E    C       S +C     GS +C +C  G+  +     C  +
Sbjct: 1082 YWVNEDGTACEDLDE----CAFPGVCPSGVCTNTA-GSFSCKDCDGGYRPSPLGDSCEDV 1136

Query: 215  LTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273
              C      C    C +T    +C C PQ     +G  C +  + + E            
Sbjct: 1137 DECEDPQSSCLGGECKNTVGSYQCLC-PQGFQLANGTVCEDVNECMGE------------ 1183

Query: 274  DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333
                      E CA +       C ++     C C  GF     G +C+D+DEC T +  
Sbjct: 1184 ----------EHCAPHG-----ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPC 1228

Query: 334  CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL--DRTCDH-SCINHPGTFACA-- 388
                C N  GSF+C C+ GF+   +   C D+DEC    D  C    C N PG++ C   
Sbjct: 1229 VGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLG 1288

Query: 389  CNRGYTLYGFTHCGDTNECSINNG-GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            C  G+ +     C D +EC+ +   G    C NT GS+ C C  G+++  +  DCV+V
Sbjct: 1289 CQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDV 1346



 Score =  144 bits (363), Expect = 4e-34
 Identities = 130/448 (29%), Positives = 184/448 (41%), Gaps = 62/448 (13%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ-GEGRQCEDIDECGNELNGGCVHDC 102
            EDVDEC      C     C+NT  SY+C C  G+Q   G  CED++EC  E +     +C
Sbjct: 1134 EDVDECEDPQSSCLGGE-CKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGEC 1192

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSD 162
            LN  G++ C C  GF+ A  G +C DVDEC   +      CVN  GS+ C C+ GF  S 
Sbjct: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252

Query: 163  NQHTCIHRSEEGLSCMNKDHG---C-SHICKEAPRGSVAC--ECRPGFELAKNQRDCI-- 214
                C+   E    C  +D+G   C +  C+ +P GS  C   C+PGF +A N  DCI  
Sbjct: 1253 ESGECVDIDE----C--EDYGDPVCGTWKCENSP-GSYRCVLGCQPGFHMAPN-GDCIDI 1304

Query: 215  -LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE--DTVLEVTESNTTSVV 271
                N    G    CD+T     C C   +++   G  C++    + +L V  +     V
Sbjct: 1305 DECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENV 1364

Query: 272  DGDKRVKRRLLMETCAVNNGGC------DRTCKDTSTGVHCSCPVG---FTLQLDGKTCK 322
            +G         +E      G C       ++  +  TG H   P     ++ Q     C 
Sbjct: 1365 EGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCS 1424

Query: 323  DI-------DECQTRNG-----GCDHFCKNIVGSFDCGCKKGFKLLTDEKS-------CQ 363
             +        EC    G      CD         F   C  G   +  E +         
Sbjct: 1425 SVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT 1484

Query: 364  DVDECSL--DRTCDHS-CINHPGTFACACNRGYTLYGFTH--CGDTNEC---SINNGGCQ 415
            D DEC +     C +  C+N    + C CN G+  Y  +H  C D +EC   +  NG   
Sbjct: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFH-YDASHKKCEDHDECQDLACENG--- 1540

Query: 416  QVCVNTVGSYECQCHPGYKLHWNKKDCV 443
              CVNT GS+ C C P   L  +++ C+
Sbjct: 1541 -ECVNTEGSFHCFCSPPLTLDLSQQRCM 1567



 Score =  119 bits (297), Expect = 2e-26
 Identities = 91/317 (28%), Positives = 134/317 (42%), Gaps = 47/317 (14%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCS-CKPGYQGE--GRQCEDIDECGNELNGGCVH 100
            ED+DECA          +C NT  S+ C  C  GY+    G  CED+DEC +  +     
Sbjct: 1092 EDLDECA--FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG 1149

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFF 159
            +C N  G+Y+C C  GF LA +G  C DV+EC+       H  C+N  GS+ C C  GF 
Sbjct: 1150 ECKNTVGSYQCLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFV 1208

Query: 160  LSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTC 217
             ++   +C    E    C   D      C     GS  C C  GF+ +    +C  I  C
Sbjct: 1209 SAEGGTSCQDVDE----CATTDPCVGGHCVNT-EGSFNCLCETGFQPSPESGECVDIDEC 1263

Query: 218  -NHGNGGC-QHSCDDTADGPEC--SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273
             ++G+  C    C+++     C   C P + M  +G  C++ ++                
Sbjct: 1264 EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECA-------------- 1308

Query: 274  DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333
                      +T   ++G CD    +T     C C  GF +   G  C D++EC+     
Sbjct: 1309 ---------NDTMCGSHGFCD----NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAV 1355

Query: 334  CD-HFCKNIVGSFDCGC 349
            C    C+N+ GSF C C
Sbjct: 1356 CGAALCENVEGSFLCLC 1372



 Score =  109 bits (272), Expect = 1e-23
 Identities = 98/338 (28%), Positives = 134/338 (39%), Gaps = 36/338 (10%)

Query: 40   AGPQEDVDECAQGLDDCHADALCQNTPTSYKC--SCKPGY-QGEGRQCEDIDECGNELNG 96
            +G   D+DEC    D       C+N+P SY+C   C+PG+       C DIDEC N+   
Sbjct: 1254 SGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMC 1313

Query: 97   GCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCK 155
            G    C N  G++RC C  GF ++  G +C+DV+EC      C    C NV GS+ C C 
Sbjct: 1314 GSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373

Query: 156  EGFFLSDNQH-TCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI 214
                  D Q   C  R   G S             EAP G  A         A  + DC 
Sbjct: 1374 SDLEEYDAQEGHCRPRGAGGQS-----------MSEAPTGDHA--------PAPTRMDC- 1413

Query: 215  LTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTV--LEVTESNTTSV-V 271
             +   G+  C           EC C  Q     D       ED+    E+  S    + V
Sbjct: 1414 YSGQKGHAPCSSVLGRNTTQAECCC-TQGASWGDACDLCPSEDSAEFSEICPSGKGYIPV 1472

Query: 272  DGDKRVKRRLLMET--CAVNNGGC--DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDEC 327
            +G     + +  +   C +   G   +  C +T  G  C C  GF      K C+D DEC
Sbjct: 1473 EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC 1532

Query: 328  QTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
            Q  +  C++  C N  GSF C C     L   ++ C +
Sbjct: 1533 Q--DLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMN 1568



 Score =  107 bits (266), Expect = 7e-23
 Identities = 119/451 (26%), Positives = 164/451 (36%), Gaps = 53/451 (11%)

Query: 73   CKPGYQGEG-RQCEDIDECGNELNGGCVHD--CLNIPGNYRCTCFDGFMLAHDGHNCLDV 129
            C  GY+      C+DI+EC   L  G   D  C+N  G+Y CTC  G ML      C+  
Sbjct: 608  CPQGYKRLNLTHCQDINEC---LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664

Query: 130  DECLENNGGCQH-----TCV-----NVMGSYECCCKEGFFLSDNQHTC-IHRSEEGLSCM 178
                   G C       TC       +     CC + G         C +  +E      
Sbjct: 665  KAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC 724

Query: 179  NKDHGCSHICKE---------------APR--GSVACECRPGFELAKNQRDCILTCNHGN 221
               HG ++   +                PR  G  +    PG   A+ Q   ++T     
Sbjct: 725  PAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPG--PAERQPLRVVTDTWLE 782

Query: 222  GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE--REDTVLEVTESNTTSVVDGDKRVKR 279
             G      D+  G   +          G +      E  + E+ E   T   D    +  
Sbjct: 783  AGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLST 842

Query: 280  RLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFC 338
              +    A     C   TC +   G  C C  G+ L      C D +EC          C
Sbjct: 843  PGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRC 902

Query: 339  KNIVGSFDCGCKKGFKLLTD--EKSCQDVDECSLDRTCD-HSCINHPGTFACACNRGYTL 395
             N VGS+ C C  G+ L T    + CQD++EC     C    C N  G++ C C++GY +
Sbjct: 903  INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962

Query: 396  YGFTHCGDTNECSINNGGCQQ-VCVNTVGSYEC-QCHPGYKLHWNKKDCVEVKGLLPTSV 453
                HC D NEC  + G C    CVN+ GSY C  C  GY+       CV+V   L    
Sbjct: 963  VRKGHCQDINECR-HPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECL---- 1015

Query: 454  SPRVSLHCGKSGGGDGCF-LRCHSGIHLSSD 483
            +P V  H GK    +G F   C  G  ++SD
Sbjct: 1016 TPGVCAH-GKCTNLEGSFRCSCEQGYEVTSD 1045



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 86/336 (25%), Positives = 124/336 (36%), Gaps = 39/336 (11%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCEDIDECGNEL--NGGCVH 100
            D DEC         +  C NT   Y C C PG  Y    ++CED DEC +    NG    
Sbjct: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENG---- 1540

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLEN----------------NGGCQHTCV 144
            +C+N  G++ C C     L      C++     E+                N  C     
Sbjct: 1541 ECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLR 1600

Query: 145  NVMGSY-ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPG 203
                +Y ECCC++G   S     C  RS E  + +     C+    EA R       RPG
Sbjct: 1601 GHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL-----CNVARIEAER-EAGVHFRPG 1654

Query: 204  FELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVT 263
            +E      D   +    +G   ++     D       P    H+  R+ +   ++ L+ +
Sbjct: 1655 YEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPI--LESPLQPS 1712

Query: 264  ESNTTSVVDGDKRVK--RRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
            E     V    +       L  E C + NG  +  C     G  C C  GF L      C
Sbjct: 1713 ELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMAC 1772

Query: 322  KDIDECQTRNGG---CDH-FCKNIVGSFDCGCKKGF 353
             D++EC   NG    C H +C+N  GS+ C C  G+
Sbjct: 1773 VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 26/74 (35%), Positives = 33/74 (44%), Gaps = 6/74 (8%)

Query: 366  DECSLDRTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNECSINNGGC----QQVCV 419
            +EC +   C++  C+     + C C  G+ L      C D NEC   NG         C 
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794

Query: 420  NTVGSYECQCHPGY 433
            NT GSY C C PGY
Sbjct: 1795 NTEGSYRCHCSPGY 1808



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 9/86 (10%)

Query: 47   DECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGG---CVHD 101
            +EC   L+ C  +  C      Y C C  G+Q +     C D++EC ++LNG    CVH 
Sbjct: 1735 EECGI-LNGCE-NGRCVRVREGYTCDCFEGFQLDAAHMACVDVNEC-DDLNGPAVLCVHG 1791

Query: 102  -CLNIPGNYRCTCFDGFMLAHDGHNC 126
             C N  G+YRC C  G++      +C
Sbjct: 1792 YCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 24/72 (33%), Positives = 38/72 (52%), Gaps = 5/72 (6%)

Query: 108 NYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHT-CVNVMGSYECCCKEGFFLSDNQHT 166
           N +  C  G+   +  H C D++ECL   G C+   CVN  GSY C C+ G  L  ++  
Sbjct: 603 NGQLECPQGYKRLNLTH-CQDINECL-TLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR 660

Query: 167 CIHRSEEGLSCM 178
           C+  S++ +S +
Sbjct: 661 CV--SDKAISML 670



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 33/196 (16%)

Query: 657  CPNGTFQNEEGQMTCEPCPR--PGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLC 714
            CP+G   N  G  TC  C     G SG+       +++EC     PG           +C
Sbjct: 980  CPDGRCVNSPGSYTCLACEEGYRGQSGS-----CVDVNEC---LTPG-----------VC 1020

Query: 715  ALGTFQPEAGRTSCFPCGGG--LATKHQGATSFQDCETRVQCSPGHFYNTT-THRCIRCP 771
            A G      G   C  C  G  + +  +G     +C +R  C  G   NT  +  C  C 
Sbjct: 1021 AHGKCTNLEGSFRC-SCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079

Query: 772  VGTYQPEFGK-----NNCV---SCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESP 823
             G +  E G      + C     CP    T+  GS +   C        LGD    ++  
Sbjct: 1080 NGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDEC 1139

Query: 824  NYPGNYPANTECTWTI 839
              P +     EC  T+
Sbjct: 1140 EDPQSSCLGGECKNTV 1155



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 33/121 (27%), Positives = 44/121 (36%), Gaps = 20/121 (16%)

Query: 657  CPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCAL 716
            CP G   N EG   C  C              + ++E G  C+      D  A   +C  
Sbjct: 1061 CPTGLCLNTEGSFACSAC-----------ENGYWVNEDGTACE----DLDECAFPGVCPS 1105

Query: 717  GTFQPEAGRTSCFPCGGGLATKHQG--ATSFQDCE-TRVQCSPGHFYNTT-THRCIRCPV 772
            G     AG  SC  C GG      G       +CE  +  C  G   NT  +++C+ CP 
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCL-CPQ 1164

Query: 773  G 773
            G
Sbjct: 1165 G 1165



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 18/42 (42%), Positives = 23/42 (54%), Gaps = 10/42 (23%)

Query: 45   DVDECAQGLDDCHADAL------CQNTPTSYKCSCKPGYQGE 80
            DV+EC    DD +  A+      C+NT  SY+C C PGY  E
Sbjct: 1774 DVNEC----DDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAE 1811



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 42/159 (26%), Positives = 51/159 (32%), Gaps = 31/159 (19%)

Query: 656  LCPNGTFQNEEGQMTCEPC-----PRPGNSGALKTPEAWN-MSEC-GGLCQ--PGEYSA- 705
            +CP+G   N  G  +C+ C     P P         E  +  S C GG C+   G Y   
Sbjct: 1102 VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCL 1161

Query: 706  --DGFAPCQLCALGTFQPEAGRTSCFP--------------CGGGLATKHQGATSFQD-- 747
               GF               G   C P              C  G  +  +G TS QD  
Sbjct: 1162 CPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSA-EGGTSCQDVD 1220

Query: 748  -CETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCV 785
             C T   C  GH  NT       C  G +QP      CV
Sbjct: 1221 ECATTDPCVGGHCVNTEGSFNCLCETG-FQPSPESGECV 1258



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 6/81 (7%)

Query: 182  HGCSHICKEAPRGSVACECRPGFELAKNQRDCILT--CNHGNGG---CQHS-CDDTADGP 235
            +GC +      R    C+C  GF+L      C+    C+  NG    C H  C++T    
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 236  ECSCHPQYKMHTDGRSCLERE 256
             C C P Y        C  +E
Sbjct: 1801 RCHCSPGYVAEAGPPHCTAKE 1821



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 2/33 (6%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPG 76
           +D++EC   L  C  DA C NT  SY C+C+PG
Sbjct: 621 QDINECLT-LGLCK-DAECVNTRGSYLCTCRPG 651



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 24/83 (28%), Positives = 30/83 (36%), Gaps = 22/83 (26%)

Query: 615  KPPRTSER-QAESCGVGQGHAENQCV--------SCRAGTYYDGARERC----------- 654
            +PP   E  QAE CG+  G    +CV         C  G   D A   C           
Sbjct: 1724 EPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNG 1783

Query: 655  --ILCPNGTFQNEEGQMTCEPCP 675
              +LC +G  +N EG   C   P
Sbjct: 1784 PAVLCVHGYCENTEGSYRCHCSP 1806



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 27/108 (25%), Positives = 39/108 (36%), Gaps = 34/108 (31%)

Query: 136 NGGCQHTCVNVMGSYECCCKEGFF-----------------LSDNQHTCIHRSEEGLSCM 178
           NG C +  + +    +CC   G F                 + + Q  C     +G   +
Sbjct: 560 NGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLEC----PQGYKRL 615

Query: 179 NKDHGCSHI--------CKEAP----RGSVACECRPGFELAKNQRDCI 214
           N  H C  I        CK+A     RGS  C CRPG  L  ++  C+
Sbjct: 616 NLTH-CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 45/195 (23%), Positives = 61/195 (31%), Gaps = 25/195 (12%)

Query: 654  CILCPNGTFQNEEGQMTCE---PCPRPG---NSGALKTPEAWNMSECGGLCQPGEY--SA 705
            C  C NG + NE+G   CE    C  PG   +     T  +++  +C G  +P     S 
Sbjct: 1075 CSACENGYWVNEDG-TACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSC 1133

Query: 706  DGFAPCQ----LCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP-GHFY 760
            +    C+     C  G  +   G   C    G             +C     C+P G   
Sbjct: 1134 EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECL 1193

Query: 761  NTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYI 820
            N+       C  G    E G     SC      D D       C    C    G F    
Sbjct: 1194 NSHGSFFCLCAPGFVSAEGG----TSC-----QDVDECATTDPCVGGHCVNTEGSFNCLC 1244

Query: 821  ESPNYPGNYPANTEC 835
            E+   P   P + EC
Sbjct: 1245 ETGFQPS--PESGEC 1257



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 15/40 (37%), Positives = 18/40 (45%)

Query: 406  ECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            EC I NG     CV     Y C C  G++L      CV+V
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDV 1775


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  177 bits (448), Expect = 6e-44
 Identities = 122/392 (31%), Positives = 174/392 (44%), Gaps = 69/392 (17%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKC----SCKPGYQGEGRQCEDIDECG---NELNG 96
            ED++EC   L  C     C NT  S+ C    +C+PGY  +  +CED+DEC    +    
Sbjct: 718  EDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQP 777

Query: 97   GCVHDCLNIPGNYRCT----CFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSY 150
            G +  C N  G++ C     C DGF+   +G NC+D++EC   +  C+   +C+N +GSY
Sbjct: 778  GFL--CQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSY 834

Query: 151  EC-----CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH--ICKEAPRGSVACECRPG 203
             C      C  G+  SD+   C+  +E    C    H C    +C   P GS  C+C+ G
Sbjct: 835  TCQRNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAG 889

Query: 204  FELAKNQRDCILT--CNHGNGG-CQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVL 260
            F+     R CI    C    G  CQH+C++T     CSC   + +  DG+ C   ED   
Sbjct: 890  FQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC---ED--- 943

Query: 261  EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
                                  +  C      C + C +      C C  G+ L  DG T
Sbjct: 944  ----------------------VNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHT 979

Query: 321  CKDIDECQTRNGG-CDHFCKNIVGSFDCGC-KKGFKLLTDEKSCQDVDECSL-DRTCD-- 375
            C DIDEC    G  C   C N+ GS+ C C ++G+ +  + +SC+DVDEC+L    C   
Sbjct: 980  CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1039

Query: 376  HSCINHPGTFAC---ACNRGYTLYGFTHCGDT 404
             +C N  G+F C    C   Y     T C  T
Sbjct: 1040 ETCHNIQGSFRCLRFECPPNYVQVSKTKCERT 1071



 Score =  176 bits (447), Expect = 7e-44
 Identities = 136/462 (29%), Positives = 190/462 (41%), Gaps = 94/462 (20%)

Query: 42   PQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQC--------------- 84
            P +D DEC   L       LC NT  SY C+C PG+  Q +GR C               
Sbjct: 601  PGDDQDECLL-LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEP 659

Query: 85   ----EDIDECGNEL------------NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
                E      N +            NG C   C  + G+  C+CF G+ +  DG +C D
Sbjct: 660  ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCED 719

Query: 129  VDECLENNGGCQHT--CVNVMGSYEC----CCKEGFFLSDNQHTCIHRSEEGLSCMNKDH 182
            ++EC+ +   C     CVN +GS+ C     C+ G+ L D +       E+   C    H
Sbjct: 720  INECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE------CEDVDECAMGTH 773

Query: 183  GCS--HICKEAPRGSVACE----CRPGFELAKNQRDC--ILTCNHGNGGCQ--HSCDDTA 232
             C    +C+   +GS  C+    C  GF L   + +C  I  C   +  C+   SC +T 
Sbjct: 774  TCQPGFLCQNT-KGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTV 831

Query: 233  DGPECSCHPQ-----YKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCA 287
                C  +P      Y    DG  C++       V E  T                    
Sbjct: 832  GSYTCQRNPLICARGYHASDDGTKCVD-------VNECET-------------------G 865

Query: 288  VNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG-CDHFCKNIVGSFD 346
            V+  G  + C +      C C  GF     G+ C D++EC    G  C H C+N +GS+ 
Sbjct: 866  VHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYR 925

Query: 347  CGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTH-CGDTN 405
            C C  GF L  D K C+DV+EC   R C   C N  G++ C C +GY L    H C D +
Sbjct: 926  CSCASGFLLAADGKRCEDVNECEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 984

Query: 406  ECSINNG-GCQQVCVNTVGSYECQC-HPGYKLHWNKKDCVEV 445
            EC+   G  C   C+N  GSY+C C   GY +  N + C +V
Sbjct: 985  ECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1026



 Score =  134 bits (337), Expect = 4e-31
 Identities = 105/375 (28%), Positives = 141/375 (37%), Gaps = 103/375 (27%)

Query: 34   PGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCS--------------------- 72
            PG     G  EDVDECA G   C    LCQNT  S+ C                      
Sbjct: 753  PGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDIN 812

Query: 73   --------CKPGY------------------------QGEGRQCEDIDECGNELNG-GCV 99
                    C+PG+                          +G +C D++EC   ++  G  
Sbjct: 813  ECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEG 872

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG-CQHTCVNVMGSYECCCKEGF 158
              C N+PG+YRC C  GF     G  C+DV+EC  + G  CQHTC N +GSY C C  GF
Sbjct: 873  QVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGF 932

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILT 216
             L+ +   C    E+   C  +   CS  C     GS  C CR G++LA++   C  I  
Sbjct: 933  LLAADGKRC----EDVNEC--EAQRCSQECANI-YGSYQCYCRQGYQLAEDGHTCTDIDE 985

Query: 217  CNHGNG-GCQHSCDDTADGPECSCHPQ-YKMHTDGRSCLEREDTVLEVTESNTTSVVDGD 274
            C  G G  C   C +     +C+C  Q Y M  +GRSC +                    
Sbjct: 986  CAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD-------------------- 1025

Query: 275  KRVKRRLLMETCAVNNGGCD--RTCKDTSTGVHC---SCPVGFT----LQLDGKTCKDID 325
                    ++ CA+    C    TC +      C    CP  +      + +  TC D  
Sbjct: 1026 --------VDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFL 1077

Query: 326  ECQTRNGGCDHFCKN 340
            ECQ       H+  N
Sbjct: 1078 ECQNSPARITHYQLN 1092



 Score =  130 bits (327), Expect = 6e-30
 Identities = 129/445 (28%), Positives = 179/445 (40%), Gaps = 70/445 (15%)

Query: 39  AAGPQE--DVDECAQGLDDCHADALCQNTP----TSY--KCSCKPGYQG--EGRQC--ED 86
           AAG Q   D DEC +  +    D +C+        SY  + SC  G  G  EG  C  ED
Sbjct: 447 AAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAED 506

Query: 87  IDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            D CG  L   C  DC          C  G  +  +G +C       E+N    + C +V
Sbjct: 507 NDSCGISLYKQCC-DC----------CGLGLRVRAEGQSC-------ESNPNLGYPCNHV 548

Query: 147 MGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFEL 206
           M S  CC  E   +       + R  E  +   +        +EA       E  P    
Sbjct: 549 MLS--CCEGEEPLIVPE----VRRPPEPAAAPRRVSEAEMAGREALSLGTEAEL-PNSLP 601

Query: 207 AKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCL------EREDTVL 260
             +Q +C+L        CQH C +T     C+C P + +  DGR+C       + E    
Sbjct: 602 GDDQDECLLLPGE---LCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658

Query: 261 EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
              +S  + V      +   L       +NG C + C        CSC  G+ +  DG +
Sbjct: 659 PALKSEFSQV--ASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 321 CKDIDECQTRNGGCD--HFCKNIVGSFDC----GCKKGFKLLTDEKSCQDVDECSL-DRT 373
           C+DI+EC T    C     C N +GSF C     C+ G+ L   E  C+DVDEC++   T
Sbjct: 717 CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHT 774

Query: 374 CDHS--CINHPGTFAC----ACNRGYTLYGFTHCGDTNECSINNGGCQQ--VCVNTVGSY 425
           C     C N  G+F C     C  G+      +C D NEC+  +  C+    C+NTVGSY
Sbjct: 775 CQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSY 834

Query: 426 ECQ-----CHPGYKLHWNKKDCVEV 445
            CQ     C  GY    +   CV+V
Sbjct: 835 TCQRNPLICARGYHASDDGTKCVDV 859


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  176 bits (445), Expect = 1e-43
 Identities = 141/483 (29%), Positives = 192/483 (39%), Gaps = 89/483 (18%)

Query: 42   PQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQC--------------- 84
            P +D DEC   L       LC NT  SY C+C PG+  Q +GR C               
Sbjct: 601  PGDDQDECLL-LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEP 659

Query: 85   ----EDIDECGNEL------------NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD 128
                E      N +            NG C   C  + G+  C+CF G+ +  DG +C D
Sbjct: 660  ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCED 719

Query: 129  VDECLENNGGCQHT--CVNVMGSYECC-----CKEGFFLSDNQH--------TCIHRSEE 173
             DECL     C     CVN +GS+ C      C +G+ L+ ++         T +H    
Sbjct: 720  QDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSR 779

Query: 174  GLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHS--CDDT 231
            G  C+N   G  H  K       A  C PG+ L   + + +  C  G   CQ    C +T
Sbjct: 780  GEHCVNT-LGSFHCYK-------ALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNT 831

Query: 232  ADGPECS----CHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVD--GDKRVKRRLLMET 285
                 C     C   +    +G      E T L        S ++  G    +R  L+  
Sbjct: 832  KGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICA 891

Query: 286  CAVNNGGCDRTCKDTS---TGVH----------------CSCPVGFTLQLDGKTCKDIDE 326
               +       C D +   TGVH                C C  GF     G+ C D++E
Sbjct: 892  RGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE 951

Query: 327  CQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTF 385
            C    G  C H C+N +GS+ C C  GF L  D K C+DV+EC   R C   C N  G++
Sbjct: 952  CWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR-CSQECANIYGSY 1010

Query: 386  ACACNRGYTLYGFTH-CGDTNECSINNG-GCQQVCVNTVGSYECQC-HPGYKLHWNKKDC 442
             C C +GY L    H C D +EC+   G  C   C+N  GSY+C C   GY +  N + C
Sbjct: 1011 QCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSC 1070

Query: 443  VEV 445
             +V
Sbjct: 1071 KDV 1073



 Score =  162 bits (411), Expect = 1e-39
 Identities = 124/439 (28%), Positives = 174/439 (39%), Gaps = 116/439 (26%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKC-------------------------------- 71
            ED DEC  G  DC     C NT  S+ C                                
Sbjct: 718  EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTC 777

Query: 72   -------------------SCKPGYQGEGRQCEDIDECG---NELNGGCVHDCLNIPGNY 109
                               +C+PGY  +  +CED+DEC    +    G +  C N  G++
Sbjct: 778  SRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFL--CQNTKGSF 835

Query: 110  RC----TCFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYEC-----CCKEGF 158
             C     C DGF+   +G NC+D++EC   +  C+   +C+N +GSY C      C  G+
Sbjct: 836  YCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGY 894

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGC--SHICKEAPRGSVACECRPGFELAKNQRDCI-- 214
              SD+   C+  +E    C    H C    +C   P GS  C+C+ GF+     R CI  
Sbjct: 895  HASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAGFQRDAFGRGCIDV 949

Query: 215  LTCNHGNGG-CQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273
              C    G  CQH+C++T     CSC   + +  DG+ C   ED                
Sbjct: 950  NECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC---ED---------------- 990

Query: 274  DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNG- 332
                     +  C      C + C +      C C  G+ L  DG TC DIDEC    G 
Sbjct: 991  ---------VNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGI 1039

Query: 333  GCDHFCKNIVGSFDCGC-KKGFKLLTDEKSCQDVDECSL-DRTCD--HSCINHPGTFAC- 387
             C   C N+ GS+ C C ++G+ +  + +SC+DVDEC+L    C    +C N  G+F C 
Sbjct: 1040 LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1099

Query: 388  --ACNRGYTLYGFTHCGDT 404
               C   Y     T C  T
Sbjct: 1100 RFECPPNYVQVSKTKCERT 1118



 Score =  152 bits (385), Expect = 1e-36
 Identities = 107/369 (28%), Positives = 163/369 (44%), Gaps = 53/369 (14%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKC----SCKPGYQGEGRQCEDIDECG---NELNGG 97
            D++EC   L  C     C NT  S+ C    +C+PGY  +  +CED+DEC    +    G
Sbjct: 766  DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPG 825

Query: 98   CVHDCLNIPGNYRCT----CFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYE 151
             +  C N  G++ C     C DGF+   +G NC+D++EC   +  C+   +C+N +GSY 
Sbjct: 826  FL--CQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYT 882

Query: 152  C-----CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH--ICKEAPRGSVACECRPGF 204
            C      C  G+  SD+   C+  +E    C    H C    +C   P GS  C+C+ GF
Sbjct: 883  CQRNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAGF 937

Query: 205  ELAKNQRDCILT--CNHGNGG-CQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLE 261
            +     R CI    C    G  CQH+C++T     CSC   + +  DG+ C +  +   +
Sbjct: 938  QRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ 997

Query: 262  VTESNTTSVVDGDKRVKRRLL-----------METCAVNNGG-CDRTCKDTSTGVHCSCP 309
                   ++    +   R+             ++ CA   G  C   C +      C+CP
Sbjct: 998  RCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACP 1057

Query: 310  V-GFTLQLDGKTCKDIDECQTRNGGCD--HFCKNIVGSFDC---GCKKGF----KLLTDE 359
              G+T+  +G++CKD+DEC      C     C NI GSF C    C   +    K   + 
Sbjct: 1058 EQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCER 1117

Query: 360  KSCQDVDEC 368
             +C D  EC
Sbjct: 1118 TTCHDFLEC 1126



 Score =  134 bits (337), Expect = 4e-31
 Identities = 105/375 (28%), Positives = 141/375 (37%), Gaps = 103/375 (27%)

Query: 34   PGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCS--------------------- 72
            PG     G  EDVDECA G   C    LCQNT  S+ C                      
Sbjct: 800  PGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDIN 859

Query: 73   --------CKPGY------------------------QGEGRQCEDIDECGNELNG-GCV 99
                    C+PG+                          +G +C D++EC   ++  G  
Sbjct: 860  ECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEG 919

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG-CQHTCVNVMGSYECCCKEGF 158
              C N+PG+YRC C  GF     G  C+DV+EC  + G  CQHTC N +GSY C C  GF
Sbjct: 920  QVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGF 979

Query: 159  FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILT 216
             L+ +   C    E+   C  +   CS  C     GS  C CR G++LA++   C  I  
Sbjct: 980  LLAADGKRC----EDVNEC--EAQRCSQECANI-YGSYQCYCRQGYQLAEDGHTCTDIDE 1032

Query: 217  CNHGNG-GCQHSCDDTADGPECSCHPQ-YKMHTDGRSCLEREDTVLEVTESNTTSVVDGD 274
            C  G G  C   C +     +C+C  Q Y M  +GRSC +                    
Sbjct: 1033 CAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD-------------------- 1072

Query: 275  KRVKRRLLMETCAVNNGGCD--RTCKDTSTGVHC---SCPVGFT----LQLDGKTCKDID 325
                    ++ CA+    C    TC +      C    CP  +      + +  TC D  
Sbjct: 1073 --------VDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFL 1124

Query: 326  ECQTRNGGCDHFCKN 340
            ECQ       H+  N
Sbjct: 1125 ECQNSPARITHYQLN 1139



 Score =  133 bits (335), Expect = 7e-31
 Identities = 138/488 (28%), Positives = 191/488 (39%), Gaps = 74/488 (15%)

Query: 39  AAGPQE--DVDECAQGLDDCHADALCQNTP----TSY--KCSCKPGYQG--EGRQC--ED 86
           AAG Q   D DEC +  +    D +C+        SY  + SC  G  G  EG  C  ED
Sbjct: 447 AAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAED 506

Query: 87  IDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            D CG  L   C  DC          C  G  +  +G +C       E+N    + C +V
Sbjct: 507 NDSCGISLYKQCC-DC----------CGLGLRVRAEGQSC-------ESNPNLGYPCNHV 548

Query: 147 MGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFEL 206
           M S  CC  E   +       + R  E  +   +        +EA       E  P    
Sbjct: 549 MLS--CCEGEEPLIVPE----VRRPPEPAAAPRRVSEAEMAGREALSLGTEAEL-PNSLP 601

Query: 207 AKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCL------EREDTVL 260
             +Q +C+L        CQH C +T     C+C P + +  DGR+C       + E    
Sbjct: 602 GDDQDECLLLPGE---LCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658

Query: 261 EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
              +S  + V      +   L       +NG C + C        CSC  G+ +  DG +
Sbjct: 659 PALKSEFSQV--ASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVS 716

Query: 321 CKDIDECQTRNGGCD--HFCKNIVGSFDCG-----CKKGFKLLTDEKSCQDVDECSLD-R 372
           C+D DEC      C    FC N +GSF C      C  G+ +L   + C D++EC  D  
Sbjct: 717 CEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGY-ILNAHRKCVDINECVTDLH 775

Query: 373 TCDHS--CINHPGTFAC----ACNRGYTLYGFTHCGDTNECSINNGGCQQ--VCVNTVGS 424
           TC     C+N  G+F C     C  GY L     C D +EC++    CQ   +C NT GS
Sbjct: 776 TCSRGEHCVNTLGSFHCYKALTCEPGYALKD-GECEDVDECAMGTHTCQPGFLCQNTKGS 834

Query: 425 YECQ----CHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCF---LRCHSG 477
           + CQ    C  G+ L   + +CV++      S   R    C  + G   C    L C  G
Sbjct: 835 FYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARG 893

Query: 478 IHLSSDVT 485
            H S D T
Sbjct: 894 YHASDDGT 901



 Score =  133 bits (334), Expect = 9e-31
 Identities = 125/406 (30%), Positives = 170/406 (41%), Gaps = 75/406 (18%)

Query: 128 DVDECLENNGG-CQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
           D DECL   G  CQH C+N +GSY C C  GF L D          +G +C  + H    
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQD----------DGRTCRPEGHPPQP 653

Query: 187 ICKEAPR-----GSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHP 241
              + P        VA    P   L   Q +   TC   NG C+  C        CSC P
Sbjct: 654 EAPQEPALKSEFSQVASNTIP---LPLPQPN---TCK-DNGPCKQVCSTVGGSAICSCFP 706

Query: 242 QYKMHTDGRSCLEREDTVLEVTE-----------------SNTTSVVDGDKRVKRRLLME 284
            Y +  DG SC ++++ ++   +                 ++T    DG      R  ++
Sbjct: 707 GYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVD 766

Query: 285 --TCAVNNGGCDR--TCKDTSTGVHC----SCPVGFTLQLDGKTCKDIDECQTRNGGCD- 335
              C  +   C R   C +T    HC    +C  G+ L+ DG+ C+D+DEC      C  
Sbjct: 767 INECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGE-CEDVDECAMGTHTCQP 824

Query: 336 -HFCKNIVGSFDC----GCKKGFKLLTDEKSCQDVDEC-SLDRTC--DHSCINHPGTFAC 387
              C+N  GSF C     C  GF L   E +C D++EC SL   C    SCIN  G++ C
Sbjct: 825 GFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTC 883

Query: 388 -----ACNRGY-TLYGFTHCGDTNEC--SINNGGCQQVCVNTVGSYECQCHPGYKLHWNK 439
                 C RGY      T C D NEC   ++  G  QVC N  GSY C C  G++     
Sbjct: 884 QRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFG 943

Query: 440 KDCVEVKGLLPTSVSP-RVSLH-CGKSGGGDGCFLRCHSGIHLSSD 483
           + C++V        SP R+  H C  + G   C   C SG  L++D
Sbjct: 944 RGCIDVN---ECWASPGRLCQHTCENTLGSYRC--SCASGFLLAAD 984


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score =  175 bits (444), Expect = 2e-43
 Identities = 130/454 (28%), Positives = 186/454 (40%), Gaps = 51/454 (11%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVHDC 102
           DVDEC +    C A   C+N+P S++C C PG++   R  +C D+DEC        +  C
Sbjct: 520 DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 578

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLS 161
            N PG++ C C  G+  A  G +C DVDEC ++ G C +  C N+ GS+ C C  GF   
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 635

Query: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
                C    E+   C  +   C     +   GS  C C  GF        C  +  C  
Sbjct: 636 -RGSAC---EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691

Query: 220 GNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278
               C +  C++T    +C C   ++ +T G  C   ED                     
Sbjct: 692 SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC---ED--------------------- 727

Query: 279 RRLLMETCAVNNGGCDRTCKDTSTGVHC-SCPVGFTLQLDGKTCKDIDECQTRNGGC--D 335
               ++ C  +     + C ++     C +CP G    L    C D+DEC +    C   
Sbjct: 728 ----VDECENHLACPGQECVNSPGSFQCRTCPSGH--HLHRGRCTDVDECSSGAPPCGPH 781

Query: 336 HFCKNIVGSFDCGCKKGFKLLTDEKS-CQDVDECSLDRTC--DHSCINHPGTFACACNRG 392
             C N  GSF C C  G++  +     C DV+EC     C     C+N  G+FAC C  G
Sbjct: 782 GHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPG 841

Query: 393 YTL-YGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPT 451
           Y        C D +ECS  +     +C NT GS+EC C PG++   +   C++V      
Sbjct: 842 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRER 901

Query: 452 SVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVT 485
             +   S  C  S G   C   C  G H   + T
Sbjct: 902 GPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT 935



 Score =  173 bits (439), Expect = 6e-43
 Identities = 130/432 (30%), Positives = 179/432 (41%), Gaps = 54/432 (12%)

Query: 32   VPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDE 89
            V P   R +  +EDVDECAQ    C     C NT  S+ C+C  G++  G G  C+D+DE
Sbjct: 630  VCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 688

Query: 90   CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMG 148
            C           C N  G+++C C  GF     G  C DVDEC EN+  C    CVN  G
Sbjct: 689  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPG 747

Query: 149  SYEC-CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELA 207
            S++C  C  G  L   + T +     G         C++       GS  C C PG+   
Sbjct: 748  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAP 802

Query: 208  KNQRD-C--ILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVT 263
              +   C  +  C  G+    H  C +T     C+C P Y+    G SCL+         
Sbjct: 803  SGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLD--------- 853

Query: 264  ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
                               ++ C+  +      C +T     C CP G     D  +C D
Sbjct: 854  -------------------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 894

Query: 324  IDECQTRNGGC--DHFCKNIVGSFDC--GCKKGFKLLTDEKSCQDVDECSL--DRTCD-H 376
            +DEC+ R         C+N  GS+ C   C  G+     E +C DVDEC       C   
Sbjct: 895  VDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQEYGPEICGAQ 953

Query: 377  SCINHPGTFAC--ACNRGYTLYGFTHCGDTNECSINNG-GCQQVCVNTVGSYECQCHPGY 433
             C N PG++ C  AC+ GY       C D +EC   +  G   VC N  GS++C C  GY
Sbjct: 954  RCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1013

Query: 434  KLHWNKKDCVEV 445
            +   + + CV+V
Sbjct: 1014 EGARDGRHCVDV 1025



 Score =  160 bits (406), Expect = 4e-39
 Identities = 114/383 (29%), Positives = 151/383 (39%), Gaps = 67/383 (17%)

Query: 63  QNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHD 122
           ++ P+S  C   P   G GR                   C++ P  Y C C  GF L+  
Sbjct: 474 ESGPSSGMCQRNPQVCGPGR-------------------CISRPSGYTCACDSGFRLSPQ 514

Query: 123 GHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKD 181
           G  C+DVDEC      C    C N  GS+ C C  GF        C+   E    C    
Sbjct: 515 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE----CHRVP 570

Query: 182 HGCS-HICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGC-QHSCDDTADGPEC 237
             C    C+  P GS  C C  G++ A +   C  +  C    G C + +C +      C
Sbjct: 571 PPCDLGRCENTP-GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 629

Query: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC-DRT 296
            C   ++    G +C E  D                            CA     C    
Sbjct: 630 VCPAGFR----GSACEEDVD---------------------------ECAQEPPPCGPGR 658

Query: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKL 355
           C +T+   HC+CP GF  +  G  C+D+DEC      C +  C+N  GSF C C  GF+ 
Sbjct: 659 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 718

Query: 356 LTDEKSCQDVDECSLDRTC-DHSCINHPGTFAC-ACNRGYTLYGFTHCGDTNECSINNGG 413
            T    C+DVDEC     C    C+N PG+F C  C  G+ L+    C D +ECS     
Sbjct: 719 NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GRCTDVDECSSGAPP 777

Query: 414 C--QQVCVNTVGSYECQCHPGYK 434
           C     C NT GS+ C C PGY+
Sbjct: 778 CGPHGHCTNTEGSFRCSCAPGYR 800



 Score =  142 bits (358), Expect = 2e-33
 Identities = 108/334 (32%), Positives = 143/334 (42%), Gaps = 54/334 (16%)

Query: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ---GEGRQCEDIDE 89
            P G     G   DVDEC+ G   C     C NT  S++CSC PGY+   G    C D++E
Sbjct: 755  PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 814

Query: 90   CGNELNGGCVH---DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            C   L G       +CLN  G++ CTC  G+     G +CLDVDEC E +      C N 
Sbjct: 815  C---LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 871

Query: 147  MGSYECCCKEGFFLSDNQHTCIHRSEEGL-SCMNKDHGCSHICKE---APRGSVACECRP 202
             GS+EC C  G           HR+   L SC++ D      C+E   A  GS  CE  P
Sbjct: 872  DGSFECICPPG-----------HRAGPDLASCLDVDE-----CRERGPALCGSQRCENSP 915

Query: 203  GFELAKNQRDCILTCNHG-NGGCQHSCDDTAD----GPECSCHPQYKMHTDGR-SCLERE 256
            G         C+  C+ G + G + +CDD  +    GPE  C  Q   +T G   C    
Sbjct: 916  G------SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEI-CGAQRCENTPGSYRCTPAC 968

Query: 257  DTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQL 316
            D   + T       VD     + R           G    C++      C C  G+    
Sbjct: 969  DPGYQPTPGGGCQDVD---ECRNRSFC--------GAHAVCQNLPGSFQCLCDQGYEGAR 1017

Query: 317  DGKTCKDIDECQTRNGGCD-HFCKNIVGSFDCGC 349
            DG+ C D++EC+T  G C    C+N+ GSF C C
Sbjct: 1018 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1051



 Score =  128 bits (322), Expect = 2e-29
 Identities = 141/559 (25%), Positives = 207/559 (37%), Gaps = 114/559 (20%)

Query: 73  CKPGYQGEGRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
           C  G++     CED+DEC     G C H +C N  G Y C C DGF+L     +C+    
Sbjct: 277 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 334

Query: 132 CLE---------NNGGCQHTCVNVMGSYECCC-KEGFFLSDNQHTCIHRSEEGL------ 175
             E          +GGC    +  +    CCC + G         C     EG       
Sbjct: 335 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 394

Query: 176 ------SCMNKDHGCSHICKEAPRGSVA----------------------------CECR 201
                 S  +  +    + +E PR S++                             + R
Sbjct: 395 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPR 454

Query: 202 PGFELAKNQRDC-----ILTCNHGNGGCQHS--------CDDTADGPECSCHPQYKMHTD 248
           PG EL            I      +G CQ +        C     G  C+C   +++   
Sbjct: 455 PGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQ 514

Query: 249 GRSCLEREDT----------VLEVTESNTTSVVDGDKRVKRR----LLMETCAVNNGGCD 294
           G  C++ ++             E +  +   V     R   R    L ++ C      CD
Sbjct: 515 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD 574

Query: 295 -RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKG 352
              C++T     C CP G+     G +C+D+DEC    G C    CKN+ GSF C C  G
Sbjct: 575 LGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAG 634

Query: 353 FKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRGYTLYG-FTHCGDTNECSI 409
           F+    E   +DVDEC+ +   C    C N  G+F CAC  G+   G    C D +EC+ 
Sbjct: 635 FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691

Query: 410 NNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGD 468
           +   C    C NT GS++C C  G++ +    +C +V         P     C  S G  
Sbjct: 692 SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP--GQECVNSPGSF 749

Query: 469 GCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKH-SSVKESF 527
            C   C SG H               L+ G+C+  + +    G  P  P  H ++ + SF
Sbjct: 750 QC-RTCPSGHH---------------LHRGRCT--DVDECSSGAPPCGPHGHCTNTEGSF 791

Query: 528 RYVNLTCSSGKQVP-GAPG 545
           R    +C+ G + P G PG
Sbjct: 792 R---CSCAPGYRAPSGRPG 807



 Score =  127 bits (318), Expect = 7e-29
 Identities = 125/431 (29%), Positives = 169/431 (39%), Gaps = 60/431 (13%)

Query: 33   PPGRGRAAGPQE----DVDECAQGLDDCHADALCQNTPTSYKC--SCKPGYQ-GEGRQCE 85
            PPG    AGP      DVDEC +          C+N+P SY+C   C PGY  G    C+
Sbjct: 880  PPGH--RAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD 937

Query: 86   DIDEC---GNELNGGCVHDCLNIPGNYRCT--CFDGFMLAHDGHNCLDVDECLENNG-GC 139
            D+DEC   G E+ G     C N PG+YRCT  C  G+     G  C DVDEC   +  G 
Sbjct: 938  DVDECQEYGPEICGA--QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGA 994

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACE 199
               C N+ GS++C C +G+  + +   C+  +E    C      C     E   GS  C 
Sbjct: 995  HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCV 1050

Query: 200  CRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTV 259
            C    E         +      G    S       P     P        R    R+  V
Sbjct: 1051 CPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPP-PPPLPRRPSTPRQGPV 1109

Query: 260  LEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGK 319
                         G  R  R    +T A +   CD       T   C C VG   +  G 
Sbjct: 1110 -------------GSGR--RECYFDTAAPD--ACDNILARNVTWQECCCTVG---EGWGS 1149

Query: 320  TCKDIDECQ-TRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQ-DVDECSL--DRTCD 375
             C+ I +C  T        C +          +G+   + + S + DVDEC L  D+ C 
Sbjct: 1150 GCR-IQQCPGTETAEYQSLCPH---------GRGYLAPSGDLSLRRDVDECQLFRDQVCK 1199

Query: 376  HS-CINHPGTFACACNRGYTLYGFT-HCGDTNECSINNGGCQQV-CVNTVGSYECQCHPG 432
               C+N    ++C C+ GY  +     C D +EC+     C+   CVNTVGSY C C P 
Sbjct: 1200 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPP 1259

Query: 433  YKLHWNKKDCV 443
              L  +++ CV
Sbjct: 1260 LVLDGSQRRCV 1270



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 107/430 (24%), Positives = 147/430 (34%), Gaps = 93/430 (21%)

Query: 30  GAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDE 89
           G  P G  R  G  EDVDECA G    H +  C NT   Y C C  G+            
Sbjct: 275 GPCPTGFERVNGSCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGF------------ 320

Query: 90  CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGS 149
                          +  + R +C    +++     C  V      +GGC    +  +  
Sbjct: 321 ---------------LLDSSRSSCISQHVISEAKGPCFRV----LRDGGCSLPILRNITK 361

Query: 150 YECCC-KEGFFLSDNQHTCIHRSEEGL------------SCMNKDHGCSHICKEAPRGSV 196
             CCC + G         C     EG             S  +  +    + +E PR S+
Sbjct: 362 QICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 421

Query: 197 ACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
           +   +P    A ++        H          D   GPE    P     T         
Sbjct: 422 S---QPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPL-PSIPAWTGP------- 470

Query: 257 DTVLEVTESNTTS-------VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP 309
               E+ ES  +S        V G  R   R    TCA     CD   + +  G  C   
Sbjct: 471 ----EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCA-----CDSGFRLSPQGTRC--- 518

Query: 310 VGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC- 368
                 +D   C+ +       G C+    N  GSF C C  GF+       C DVDEC 
Sbjct: 519 ------IDVDECRRVPP-PCAPGRCE----NSPGSFRCVCGPGFRAGPRAAECLDVDECH 567

Query: 369 SLDRTCD-HSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINNGGC-QQVCVNTVGS 424
            +   CD   C N PG+F C C  GY    +G   C D +EC+ + G C +  C N  GS
Sbjct: 568 RVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG-ASCQDVDECTQSPGLCGRGACKNLPGS 626

Query: 425 YECQCHPGYK 434
           + C C  G++
Sbjct: 627 FRCVCPAGFR 636



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 45/145 (31%), Positives = 61/145 (42%), Gaps = 20/145 (13%)

Query: 33   PPGRGRAAGP-----QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCE 85
            P GRG  A       + DVDEC    D      +C NT   Y C C  G  Y  +  +C 
Sbjct: 1169 PHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECI 1228

Query: 86   DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGG------ 138
            D DEC +E        C+N  G+Y CTC    +L      C+ +  + L++N G      
Sbjct: 1229 DNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEV 1288

Query: 139  -----CQHTCVNVMGSY-ECCCKEG 157
                 C H  ++   +Y ECCC  G
Sbjct: 1289 GADLVCSHPRLDRQATYTECCCLYG 1313



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 44/158 (27%), Positives = 62/158 (39%), Gaps = 16/158 (10%)

Query: 62   CQNTPTS-YKCSCKPGY-----QGEGRQCEDIDECGNELNGGCVHD-CLNIPGNYRCTCF 114
            C  T T+ Y+  C  G       G+     D+DEC    +  C    C+N    Y C C 
Sbjct: 1156 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1215

Query: 115  DGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEE 173
            +G+        C+D DEC +    C+   CVN +GSY C C+    L  +Q  C+    +
Sbjct: 1216 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQ 1275

Query: 174  GLS-----C---MNKDHGCSHICKEAPRGSVACECRPG 203
             L      C   +  D  CSH   +       C C  G
Sbjct: 1276 SLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1313



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 7/87 (8%)

Query: 86   DIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQH 141
            + +ECG  +  GC +  C+ +P  + C CFDG+ L      C+D++EC E       C +
Sbjct: 1466 EAEECG--ILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 142  T-CVNVMGSYECCCKEGFFLSDNQHTC 167
              C+N  GS+ C C+ GF  +   H C
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 9/103 (8%)

Query: 33   PPGRGRAAG----PQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CED 86
            PP  G  AG    P E+++    G+ D   +  C   P  + C C  GY+ +  +  C D
Sbjct: 1448 PPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507

Query: 87   IDEC--GNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNC 126
            I+EC      +  CV+  CLN  G++RC C  GF   H  H+C
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 57/205 (27%), Positives = 77/205 (37%), Gaps = 34/205 (16%)

Query: 24   PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADAL----CQN----TPTSYKCSCKP 75
            P+L      PP   R + P++       G  +C+ D      C N      T  +C C  
Sbjct: 1086 PVLPARPPPPPLPRRPSTPRQG--PVGSGRRECYFDTAAPDACDNILARNVTWQECCCTV 1143

Query: 76   GYQGEGRQCEDIDEC-GNELNGGCVHDCLNIPGNYRCTCFDGF-MLAHDGHNCL--DVDE 131
            G +G G  C  I +C G E               Y+  C  G   LA  G   L  DVDE
Sbjct: 1144 G-EGWGSGCR-IQQCPGTET------------AEYQSLCPHGRGYLAPSGDLSLRRDVDE 1189

Query: 132  C-LENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
            C L  +  C+   CVN    Y C C  G++    +  CI   E    C +++  C     
Sbjct: 1190 CQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACEGGRC 1245

Query: 190  EAPRGSVACECRPGFELAKNQRDCI 214
                GS  C C P   L  +QR C+
Sbjct: 1246 VNTVGSYHCTCEPPLVLDGSQRRCV 1270



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/111 (27%), Positives = 43/111 (38%), Gaps = 15/111 (13%)

Query: 297  CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKL 355
            C +T+ G  C C  G+        C D DEC      C+   C N VGS+ C C+    L
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262

Query: 356  LTDEKSC-----QDVD--------ECSLDRTCDHSCINHPGTFA-CACNRG 392
               ++ C     Q +D        E   D  C H  ++   T+  C C  G
Sbjct: 1263 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1313



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 8/77 (10%)

Query: 364  DVDECS-LDRTCDHSCINHPGTFACACNRGYTLYGFTH--CGDTNECSINNGG---CQQV 417
            + +EC  LD   +  C+  P  F C C  GY L   T   C D NEC         C   
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRL-DMTRMACVDINECDEAEAASPLCVNA 1524

Query: 418  -CVNTVGSYECQCHPGY 433
             C+NT GS+ C C PG+
Sbjct: 1525 RCLNTDGSFRCICRPGF 1541



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 5/76 (6%)

Query: 323  DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC----SLDRTCDHS- 377
            + +EC   +G  +  C  +   F C C  G++L     +C D++EC    +    C ++ 
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 378  CINHPGTFACACNRGY 393
            C+N  G+F C C  G+
Sbjct: 1526 CLNTDGSFRCICRPGF 1541



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 18/118 (15%)

Query: 323 DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINH 381
           D   C  R G  +      V + D  C  GF+ +    SC+DVDEC+    C H  C N 
Sbjct: 256 DCQLCSERLGNSER-----VSAPDGPCPTGFERVNG--SCEDVDECATGGRCQHGECANT 308

Query: 382 PGTFACACNRGYTL-YGFTHCGDTNECS---------INNGGCQQVCVNTVGSYECQC 429
            G + C C  G+ L    + C   +  S         + +GGC    +  +    C C
Sbjct: 309 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCC 366



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 23/74 (31%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 284  ETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG----CDHFCK 339
            E C + +G  +  C     G  C C  G+ L +    C DI+EC           +  C 
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1527

Query: 340  NIVGSFDCGCKKGF 353
            N  GSF C C+ GF
Sbjct: 1528 NTDGSFRCICRPGF 1541



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 25/91 (27%), Positives = 37/91 (40%), Gaps = 9/91 (9%)

Query: 127  LDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
            L+ +EC   +G     CV V   + C C +G+ L   +  C+  +E      ++    S 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE-----CDEAEAASP 1519

Query: 187  ICKEA----PRGSVACECRPGFELAKNQRDC 213
            +C  A      GS  C CRPGF        C
Sbjct: 1520 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 2/73 (2%)

Query: 403  DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGL-LPTSVSPR-VSLH 460
            +  EC I +G     CV     + C+C  GY+L   +  CV++       + SP  V+  
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 461  CGKSGGGDGCFLR 473
            C  + G   C  R
Sbjct: 1526 CLNTDGSFRCICR 1538



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 23/90 (25%), Positives = 34/90 (37%), Gaps = 1/90 (1%)

Query: 697 LCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP 756
           +C  G   A G   CQLC+      E       PC  G    +       +C T  +C  
Sbjct: 243 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQH 302

Query: 757 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVS 786
           G   NT       CP G +  +  +++C+S
Sbjct: 303 GECANTRGGYTCVCPDG-FLLDSSRSSCIS 331



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 57/265 (21%), Positives = 85/265 (32%), Gaps = 68/265 (25%)

Query: 611 DVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERC---------ILCPNGT 661
           + A+ PP  +  + E+          QCV C  G   + A   C         + CP   
Sbjct: 688 ECARSPPPCTYGRCENT-----EGSFQCV-CPMGFQPNTAGSECEDVDECENHLACPGQE 741

Query: 662 FQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQP-GEY----SADGFAPCQLCAL 716
             N  G   C  CP   +   L      ++ EC     P G +    + +G   C  CA 
Sbjct: 742 CVNSPGSFQCRTCP---SGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCS-CAP 797

Query: 717 GTFQPEAGRTS-------------CFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTT 763
           G ++  +GR               CFP G  L T         D      C+PG+     
Sbjct: 798 G-YRAPSGRPGPCADVNECLEGDFCFPHGECLNT---------DGSFACTCAPGYRPGPR 847

Query: 764 THRCI---------RCPVGTYQPEFGKNNCVSCPGNTT-TDFDGSTNITQCKNR---RCG 810
              C+          C  G      G   C+  PG+    D     ++ +C+ R    CG
Sbjct: 848 GASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCG 907

Query: 811 GELGDFTGYIESPNYPGNYPANTEC 835
            +           N PG+Y    +C
Sbjct: 908 SQ--------RCENSPGSYRCVRDC 924


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score =  175 bits (444), Expect = 2e-43
 Identities = 130/454 (28%), Positives = 186/454 (40%), Gaps = 51/454 (11%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVHDC 102
           DVDEC +    C A   C+N+P S++C C PG++   R  +C D+DEC        +  C
Sbjct: 550 DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 608

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLS 161
            N PG++ C C  G+  A  G +C DVDEC ++ G C +  C N+ GS+ C C  GF   
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 665

Query: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
                C    E+   C  +   C     +   GS  C C  GF        C  +  C  
Sbjct: 666 -RGSAC---EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721

Query: 220 GNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278
               C +  C++T    +C C   ++ +T G  C   ED                     
Sbjct: 722 SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC---ED--------------------- 757

Query: 279 RRLLMETCAVNNGGCDRTCKDTSTGVHC-SCPVGFTLQLDGKTCKDIDECQTRNGGC--D 335
               ++ C  +     + C ++     C +CP G    L    C D+DEC +    C   
Sbjct: 758 ----VDECENHLACPGQECVNSPGSFQCRTCPSGH--HLHRGRCTDVDECSSGAPPCGPH 811

Query: 336 HFCKNIVGSFDCGCKKGFKLLTDEKS-CQDVDECSLDRTC--DHSCINHPGTFACACNRG 392
             C N  GSF C C  G++  +     C DV+EC     C     C+N  G+FAC C  G
Sbjct: 812 GHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPG 871

Query: 393 YTL-YGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPT 451
           Y        C D +ECS  +     +C NT GS+EC C PG++   +   C++V      
Sbjct: 872 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRER 931

Query: 452 SVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVT 485
             +   S  C  S G   C   C  G H   + T
Sbjct: 932 GPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT 965



 Score =  173 bits (439), Expect = 6e-43
 Identities = 130/432 (30%), Positives = 179/432 (41%), Gaps = 54/432 (12%)

Query: 32   VPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDE 89
            V P   R +  +EDVDECAQ    C     C NT  S+ C+C  G++  G G  C+D+DE
Sbjct: 660  VCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 718

Query: 90   CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMG 148
            C           C N  G+++C C  GF     G  C DVDEC EN+  C    CVN  G
Sbjct: 719  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPG 777

Query: 149  SYEC-CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELA 207
            S++C  C  G  L   + T +     G         C++       GS  C C PG+   
Sbjct: 778  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAP 832

Query: 208  KNQRD-C--ILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVT 263
              +   C  +  C  G+    H  C +T     C+C P Y+    G SCL+         
Sbjct: 833  SGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLD--------- 883

Query: 264  ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
                               ++ C+  +      C +T     C CP G     D  +C D
Sbjct: 884  -------------------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 924

Query: 324  IDECQTRNGGC--DHFCKNIVGSFDC--GCKKGFKLLTDEKSCQDVDECSL--DRTCD-H 376
            +DEC+ R         C+N  GS+ C   C  G+     E +C DVDEC       C   
Sbjct: 925  VDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQEYGPEICGAQ 983

Query: 377  SCINHPGTFAC--ACNRGYTLYGFTHCGDTNECSINNG-GCQQVCVNTVGSYECQCHPGY 433
             C N PG++ C  AC+ GY       C D +EC   +  G   VC N  GS++C C  GY
Sbjct: 984  RCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1043

Query: 434  KLHWNKKDCVEV 445
            +   + + CV+V
Sbjct: 1044 EGARDGRHCVDV 1055



 Score =  160 bits (406), Expect = 4e-39
 Identities = 114/383 (29%), Positives = 151/383 (39%), Gaps = 67/383 (17%)

Query: 63  QNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHD 122
           ++ P+S  C   P   G GR                   C++ P  Y C C  GF L+  
Sbjct: 504 ESGPSSGMCQRNPQVCGPGR-------------------CISRPSGYTCACDSGFRLSPQ 544

Query: 123 GHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKD 181
           G  C+DVDEC      C    C N  GS+ C C  GF        C+   E    C    
Sbjct: 545 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE----CHRVP 600

Query: 182 HGCS-HICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGC-QHSCDDTADGPEC 237
             C    C+  P GS  C C  G++ A +   C  +  C    G C + +C +      C
Sbjct: 601 PPCDLGRCENTP-GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 659

Query: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC-DRT 296
            C   ++    G +C E  D                            CA     C    
Sbjct: 660 VCPAGFR----GSACEEDVD---------------------------ECAQEPPPCGPGR 688

Query: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKL 355
           C +T+   HC+CP GF  +  G  C+D+DEC      C +  C+N  GSF C C  GF+ 
Sbjct: 689 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 748

Query: 356 LTDEKSCQDVDECSLDRTC-DHSCINHPGTFAC-ACNRGYTLYGFTHCGDTNECSINNGG 413
            T    C+DVDEC     C    C+N PG+F C  C  G+ L+    C D +ECS     
Sbjct: 749 NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GRCTDVDECSSGAPP 807

Query: 414 C--QQVCVNTVGSYECQCHPGYK 434
           C     C NT GS+ C C PGY+
Sbjct: 808 CGPHGHCTNTEGSFRCSCAPGYR 830



 Score =  142 bits (358), Expect = 2e-33
 Identities = 108/334 (32%), Positives = 143/334 (42%), Gaps = 54/334 (16%)

Query: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ---GEGRQCEDIDE 89
            P G     G   DVDEC+ G   C     C NT  S++CSC PGY+   G    C D++E
Sbjct: 785  PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 844

Query: 90   CGNELNGGCVH---DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            C   L G       +CLN  G++ CTC  G+     G +CLDVDEC E +      C N 
Sbjct: 845  C---LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 901

Query: 147  MGSYECCCKEGFFLSDNQHTCIHRSEEGL-SCMNKDHGCSHICKE---APRGSVACECRP 202
             GS+EC C  G           HR+   L SC++ D      C+E   A  GS  CE  P
Sbjct: 902  DGSFECICPPG-----------HRAGPDLASCLDVDE-----CRERGPALCGSQRCENSP 945

Query: 203  GFELAKNQRDCILTCNHG-NGGCQHSCDDTAD----GPECSCHPQYKMHTDGR-SCLERE 256
            G         C+  C+ G + G + +CDD  +    GPE  C  Q   +T G   C    
Sbjct: 946  G------SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEI-CGAQRCENTPGSYRCTPAC 998

Query: 257  DTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQL 316
            D   + T       VD     + R           G    C++      C C  G+    
Sbjct: 999  DPGYQPTPGGGCQDVD---ECRNRSFC--------GAHAVCQNLPGSFQCLCDQGYEGAR 1047

Query: 317  DGKTCKDIDECQTRNGGCD-HFCKNIVGSFDCGC 349
            DG+ C D++EC+T  G C    C+N+ GSF C C
Sbjct: 1048 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081



 Score =  128 bits (322), Expect = 2e-29
 Identities = 141/559 (25%), Positives = 207/559 (37%), Gaps = 114/559 (20%)

Query: 73  CKPGYQGEGRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
           C  G++     CED+DEC     G C H +C N  G Y C C DGF+L     +C+    
Sbjct: 307 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 364

Query: 132 CLE---------NNGGCQHTCVNVMGSYECCC-KEGFFLSDNQHTCIHRSEEGL------ 175
             E          +GGC    +  +    CCC + G         C     EG       
Sbjct: 365 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 424

Query: 176 ------SCMNKDHGCSHICKEAPRGSVA----------------------------CECR 201
                 S  +  +    + +E PR S++                             + R
Sbjct: 425 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPR 484

Query: 202 PGFELAKNQRDC-----ILTCNHGNGGCQHS--------CDDTADGPECSCHPQYKMHTD 248
           PG EL            I      +G CQ +        C     G  C+C   +++   
Sbjct: 485 PGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQ 544

Query: 249 GRSCLEREDT----------VLEVTESNTTSVVDGDKRVKRR----LLMETCAVNNGGCD 294
           G  C++ ++             E +  +   V     R   R    L ++ C      CD
Sbjct: 545 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD 604

Query: 295 -RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKG 352
              C++T     C CP G+     G +C+D+DEC    G C    CKN+ GSF C C  G
Sbjct: 605 LGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAG 664

Query: 353 FKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRGYTLYG-FTHCGDTNECSI 409
           F+    E   +DVDEC+ +   C    C N  G+F CAC  G+   G    C D +EC+ 
Sbjct: 665 FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721

Query: 410 NNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGD 468
           +   C    C NT GS++C C  G++ +    +C +V         P     C  S G  
Sbjct: 722 SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP--GQECVNSPGSF 779

Query: 469 GCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKH-SSVKESF 527
            C   C SG H               L+ G+C+  + +    G  P  P  H ++ + SF
Sbjct: 780 QC-RTCPSGHH---------------LHRGRCT--DVDECSSGAPPCGPHGHCTNTEGSF 821

Query: 528 RYVNLTCSSGKQVP-GAPG 545
           R    +C+ G + P G PG
Sbjct: 822 R---CSCAPGYRAPSGRPG 837



 Score =  127 bits (318), Expect = 7e-29
 Identities = 125/431 (29%), Positives = 169/431 (39%), Gaps = 60/431 (13%)

Query: 33   PPGRGRAAGPQE----DVDECAQGLDDCHADALCQNTPTSYKC--SCKPGYQ-GEGRQCE 85
            PPG    AGP      DVDEC +          C+N+P SY+C   C PGY  G    C+
Sbjct: 910  PPGH--RAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD 967

Query: 86   DIDEC---GNELNGGCVHDCLNIPGNYRCT--CFDGFMLAHDGHNCLDVDECLENNG-GC 139
            D+DEC   G E+ G     C N PG+YRCT  C  G+     G  C DVDEC   +  G 
Sbjct: 968  DVDECQEYGPEICGA--QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGA 1024

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACE 199
               C N+ GS++C C +G+  + +   C+  +E    C      C     E   GS  C 
Sbjct: 1025 HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCV 1080

Query: 200  CRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTV 259
            C    E         +      G    S       P     P        R    R+  V
Sbjct: 1081 CPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPP-PPPLPRRPSTPRQGPV 1139

Query: 260  LEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGK 319
                         G  R  R    +T A +   CD       T   C C VG   +  G 
Sbjct: 1140 -------------GSGR--RECYFDTAAPD--ACDNILARNVTWQECCCTVG---EGWGS 1179

Query: 320  TCKDIDECQ-TRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQ-DVDECSL--DRTCD 375
             C+ I +C  T        C +          +G+   + + S + DVDEC L  D+ C 
Sbjct: 1180 GCR-IQQCPGTETAEYQSLCPH---------GRGYLAPSGDLSLRRDVDECQLFRDQVCK 1229

Query: 376  HS-CINHPGTFACACNRGYTLYGFT-HCGDTNECSINNGGCQQV-CVNTVGSYECQCHPG 432
               C+N    ++C C+ GY  +     C D +EC+     C+   CVNTVGSY C C P 
Sbjct: 1230 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPP 1289

Query: 433  YKLHWNKKDCV 443
              L  +++ CV
Sbjct: 1290 LVLDGSQRRCV 1300



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 107/430 (24%), Positives = 147/430 (34%), Gaps = 93/430 (21%)

Query: 30  GAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDE 89
           G  P G  R  G  EDVDECA G    H +  C NT   Y C C  G+            
Sbjct: 305 GPCPTGFERVNGSCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGF------------ 350

Query: 90  CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGS 149
                          +  + R +C    +++     C  V      +GGC    +  +  
Sbjct: 351 ---------------LLDSSRSSCISQHVISEAKGPCFRV----LRDGGCSLPILRNITK 391

Query: 150 YECCC-KEGFFLSDNQHTCIHRSEEGL------------SCMNKDHGCSHICKEAPRGSV 196
             CCC + G         C     EG             S  +  +    + +E PR S+
Sbjct: 392 QICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 451

Query: 197 ACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
           +   +P    A ++        H          D   GPE    P     T         
Sbjct: 452 S---QPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPL-PSIPAWTGP------- 500

Query: 257 DTVLEVTESNTTS-------VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP 309
               E+ ES  +S        V G  R   R    TCA     CD   + +  G  C   
Sbjct: 501 ----EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCA-----CDSGFRLSPQGTRC--- 548

Query: 310 VGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC- 368
                 +D   C+ +       G C+    N  GSF C C  GF+       C DVDEC 
Sbjct: 549 ------IDVDECRRVPP-PCAPGRCE----NSPGSFRCVCGPGFRAGPRAAECLDVDECH 597

Query: 369 SLDRTCD-HSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINNGGC-QQVCVNTVGS 424
            +   CD   C N PG+F C C  GY    +G   C D +EC+ + G C +  C N  GS
Sbjct: 598 RVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG-ASCQDVDECTQSPGLCGRGACKNLPGS 656

Query: 425 YECQCHPGYK 434
           + C C  G++
Sbjct: 657 FRCVCPAGFR 666



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 45/145 (31%), Positives = 61/145 (42%), Gaps = 20/145 (13%)

Query: 33   PPGRGRAAGP-----QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCE 85
            P GRG  A       + DVDEC    D      +C NT   Y C C  G  Y  +  +C 
Sbjct: 1199 PHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECI 1258

Query: 86   DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGG------ 138
            D DEC +E        C+N  G+Y CTC    +L      C+ +  + L++N G      
Sbjct: 1259 DNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEV 1318

Query: 139  -----CQHTCVNVMGSY-ECCCKEG 157
                 C H  ++   +Y ECCC  G
Sbjct: 1319 GADLVCSHPRLDRQATYTECCCLYG 1343



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 44/158 (27%), Positives = 62/158 (39%), Gaps = 16/158 (10%)

Query: 62   CQNTPTS-YKCSCKPGY-----QGEGRQCEDIDECGNELNGGCVHD-CLNIPGNYRCTCF 114
            C  T T+ Y+  C  G       G+     D+DEC    +  C    C+N    Y C C 
Sbjct: 1186 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1245

Query: 115  DGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEE 173
            +G+        C+D DEC +    C+   CVN +GSY C C+    L  +Q  C+    +
Sbjct: 1246 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQ 1305

Query: 174  GLS-----C---MNKDHGCSHICKEAPRGSVACECRPG 203
             L      C   +  D  CSH   +       C C  G
Sbjct: 1306 SLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1343



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 7/87 (8%)

Query: 86   DIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQH 141
            + +ECG  +  GC +  C+ +P  + C CFDG+ L      C+D++EC E       C +
Sbjct: 1496 EAEECG--ILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 142  T-CVNVMGSYECCCKEGFFLSDNQHTC 167
              C+N  GS+ C C+ GF  +   H C
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 9/103 (8%)

Query: 33   PPGRGRAAG----PQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CED 86
            PP  G  AG    P E+++    G+ D   +  C   P  + C C  GY+ +  +  C D
Sbjct: 1478 PPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537

Query: 87   IDEC--GNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNC 126
            I+EC      +  CV+  CLN  G++RC C  GF   H  H+C
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 57/205 (27%), Positives = 77/205 (37%), Gaps = 34/205 (16%)

Query: 24   PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADAL----CQN----TPTSYKCSCKP 75
            P+L      PP   R + P++       G  +C+ D      C N      T  +C C  
Sbjct: 1116 PVLPARPPPPPLPRRPSTPRQG--PVGSGRRECYFDTAAPDACDNILARNVTWQECCCTV 1173

Query: 76   GYQGEGRQCEDIDEC-GNELNGGCVHDCLNIPGNYRCTCFDGF-MLAHDGHNCL--DVDE 131
            G +G G  C  I +C G E               Y+  C  G   LA  G   L  DVDE
Sbjct: 1174 G-EGWGSGCR-IQQCPGTET------------AEYQSLCPHGRGYLAPSGDLSLRRDVDE 1219

Query: 132  C-LENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
            C L  +  C+   CVN    Y C C  G++    +  CI   E    C +++  C     
Sbjct: 1220 CQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACEGGRC 1275

Query: 190  EAPRGSVACECRPGFELAKNQRDCI 214
                GS  C C P   L  +QR C+
Sbjct: 1276 VNTVGSYHCTCEPPLVLDGSQRRCV 1300



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/111 (27%), Positives = 43/111 (38%), Gaps = 15/111 (13%)

Query: 297  CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKL 355
            C +T+ G  C C  G+        C D DEC      C+   C N VGS+ C C+    L
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292

Query: 356  LTDEKSC-----QDVD--------ECSLDRTCDHSCINHPGTFA-CACNRG 392
               ++ C     Q +D        E   D  C H  ++   T+  C C  G
Sbjct: 1293 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1343



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 8/77 (10%)

Query: 364  DVDECS-LDRTCDHSCINHPGTFACACNRGYTLYGFTH--CGDTNECSINNGG---CQQV 417
            + +EC  LD   +  C+  P  F C C  GY L   T   C D NEC         C   
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRL-DMTRMACVDINECDEAEAASPLCVNA 1554

Query: 418  -CVNTVGSYECQCHPGY 433
             C+NT GS+ C C PG+
Sbjct: 1555 RCLNTDGSFRCICRPGF 1571



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 5/76 (6%)

Query: 323  DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC----SLDRTCDHS- 377
            + +EC   +G  +  C  +   F C C  G++L     +C D++EC    +    C ++ 
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 378  CINHPGTFACACNRGY 393
            C+N  G+F C C  G+
Sbjct: 1556 CLNTDGSFRCICRPGF 1571



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 18/118 (15%)

Query: 323 DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINH 381
           D   C  R G  +      V + D  C  GF+ +    SC+DVDEC+    C H  C N 
Sbjct: 286 DCQLCSERLGNSER-----VSAPDGPCPTGFERVNG--SCEDVDECATGGRCQHGECANT 338

Query: 382 PGTFACACNRGYTL-YGFTHCGDTNECS---------INNGGCQQVCVNTVGSYECQC 429
            G + C C  G+ L    + C   +  S         + +GGC    +  +    C C
Sbjct: 339 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCC 396



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 23/74 (31%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 284  ETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG----CDHFCK 339
            E C + +G  +  C     G  C C  G+ L +    C DI+EC           +  C 
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1557

Query: 340  NIVGSFDCGCKKGF 353
            N  GSF C C+ GF
Sbjct: 1558 NTDGSFRCICRPGF 1571



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 25/91 (27%), Positives = 37/91 (40%), Gaps = 9/91 (9%)

Query: 127  LDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
            L+ +EC   +G     CV V   + C C +G+ L   +  C+  +E      ++    S 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE-----CDEAEAASP 1549

Query: 187  ICKEA----PRGSVACECRPGFELAKNQRDC 213
            +C  A      GS  C CRPGF        C
Sbjct: 1550 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 2/73 (2%)

Query: 403  DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGL-LPTSVSPR-VSLH 460
            +  EC I +G     CV     + C+C  GY+L   +  CV++       + SP  V+  
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 461  CGKSGGGDGCFLR 473
            C  + G   C  R
Sbjct: 1556 CLNTDGSFRCICR 1568



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 23/90 (25%), Positives = 34/90 (37%), Gaps = 1/90 (1%)

Query: 697 LCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP 756
           +C  G   A G   CQLC+      E       PC  G    +       +C T  +C  
Sbjct: 273 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQH 332

Query: 757 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVS 786
           G   NT       CP G +  +  +++C+S
Sbjct: 333 GECANTRGGYTCVCPDG-FLLDSSRSSCIS 361



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 57/265 (21%), Positives = 85/265 (32%), Gaps = 68/265 (25%)

Query: 611 DVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERC---------ILCPNGT 661
           + A+ PP  +  + E+          QCV C  G   + A   C         + CP   
Sbjct: 718 ECARSPPPCTYGRCENT-----EGSFQCV-CPMGFQPNTAGSECEDVDECENHLACPGQE 771

Query: 662 FQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQP-GEY----SADGFAPCQLCAL 716
             N  G   C  CP   +   L      ++ EC     P G +    + +G   C  CA 
Sbjct: 772 CVNSPGSFQCRTCP---SGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCS-CAP 827

Query: 717 GTFQPEAGRTS-------------CFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTT 763
           G ++  +GR               CFP G  L T         D      C+PG+     
Sbjct: 828 G-YRAPSGRPGPCADVNECLEGDFCFPHGECLNT---------DGSFACTCAPGYRPGPR 877

Query: 764 THRCI---------RCPVGTYQPEFGKNNCVSCPGNTT-TDFDGSTNITQCKNR---RCG 810
              C+          C  G      G   C+  PG+    D     ++ +C+ R    CG
Sbjct: 878 GASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCG 937

Query: 811 GELGDFTGYIESPNYPGNYPANTEC 835
            +           N PG+Y    +C
Sbjct: 938 SQ--------RCENSPGSYRCVRDC 954


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  175 bits (444), Expect = 2e-43
 Identities = 130/454 (28%), Positives = 186/454 (40%), Gaps = 51/454 (11%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR--QCEDIDECGNELNGGCVHDC 102
            DVDEC +    C A   C+N+P S++C C PG++   R  +C D+DEC        +  C
Sbjct: 587  DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 645

Query: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLS 161
             N PG++ C C  G+  A  G +C DVDEC ++ G C +  C N+ GS+ C C  GF   
Sbjct: 646  ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 702

Query: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219
                 C    E+   C  +   C     +   GS  C C  GF        C  +  C  
Sbjct: 703  -RGSAC---EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758

Query: 220  GNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278
                C +  C++T    +C C   ++ +T G  C   ED                     
Sbjct: 759  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC---ED--------------------- 794

Query: 279  RRLLMETCAVNNGGCDRTCKDTSTGVHC-SCPVGFTLQLDGKTCKDIDECQTRNGGC--D 335
                ++ C  +     + C ++     C +CP G    L    C D+DEC +    C   
Sbjct: 795  ----VDECENHLACPGQECVNSPGSFQCRTCPSGH--HLHRGRCTDVDECSSGAPPCGPH 848

Query: 336  HFCKNIVGSFDCGCKKGFKLLTDEKS-CQDVDECSLDRTC--DHSCINHPGTFACACNRG 392
              C N  GSF C C  G++  +     C DV+EC     C     C+N  G+FAC C  G
Sbjct: 849  GHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPG 908

Query: 393  YTL-YGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPT 451
            Y        C D +ECS  +     +C NT GS+EC C PG++   +   C++V      
Sbjct: 909  YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRER 968

Query: 452  SVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVT 485
              +   S  C  S G   C   C  G H   + T
Sbjct: 969  GPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT 1002



 Score =  173 bits (439), Expect = 6e-43
 Identities = 130/432 (30%), Positives = 179/432 (41%), Gaps = 54/432 (12%)

Query: 32   VPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDE 89
            V P   R +  +EDVDECAQ    C     C NT  S+ C+C  G++  G G  C+D+DE
Sbjct: 697  VCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 755

Query: 90   CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMG 148
            C           C N  G+++C C  GF     G  C DVDEC EN+  C    CVN  G
Sbjct: 756  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPG 814

Query: 149  SYEC-CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELA 207
            S++C  C  G  L   + T +     G         C++       GS  C C PG+   
Sbjct: 815  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAP 869

Query: 208  KNQRD-C--ILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVT 263
              +   C  +  C  G+    H  C +T     C+C P Y+    G SCL+         
Sbjct: 870  SGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLD--------- 920

Query: 264  ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323
                               ++ C+  +      C +T     C CP G     D  +C D
Sbjct: 921  -------------------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 961

Query: 324  IDECQTRNGGC--DHFCKNIVGSFDC--GCKKGFKLLTDEKSCQDVDECSL--DRTCD-H 376
            +DEC+ R         C+N  GS+ C   C  G+     E +C DVDEC       C   
Sbjct: 962  VDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQEYGPEICGAQ 1020

Query: 377  SCINHPGTFAC--ACNRGYTLYGFTHCGDTNECSINNG-GCQQVCVNTVGSYECQCHPGY 433
             C N PG++ C  AC+ GY       C D +EC   +  G   VC N  GS++C C  GY
Sbjct: 1021 RCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1080

Query: 434  KLHWNKKDCVEV 445
            +   + + CV+V
Sbjct: 1081 EGARDGRHCVDV 1092



 Score =  160 bits (406), Expect = 4e-39
 Identities = 114/383 (29%), Positives = 151/383 (39%), Gaps = 67/383 (17%)

Query: 63  QNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHD 122
           ++ P+S  C   P   G GR                   C++ P  Y C C  GF L+  
Sbjct: 541 ESGPSSGMCQRNPQVCGPGR-------------------CISRPSGYTCACDSGFRLSPQ 581

Query: 123 GHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKD 181
           G  C+DVDEC      C    C N  GS+ C C  GF        C+   E    C    
Sbjct: 582 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE----CHRVP 637

Query: 182 HGCS-HICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGC-QHSCDDTADGPEC 237
             C    C+  P GS  C C  G++ A +   C  +  C    G C + +C +      C
Sbjct: 638 PPCDLGRCENTP-GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 696

Query: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC-DRT 296
            C   ++    G +C E  D                            CA     C    
Sbjct: 697 VCPAGFR----GSACEEDVD---------------------------ECAQEPPPCGPGR 725

Query: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKL 355
           C +T+   HC+CP GF  +  G  C+D+DEC      C +  C+N  GSF C C  GF+ 
Sbjct: 726 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785

Query: 356 LTDEKSCQDVDECSLDRTC-DHSCINHPGTFAC-ACNRGYTLYGFTHCGDTNECSINNGG 413
            T    C+DVDEC     C    C+N PG+F C  C  G+ L+    C D +ECS     
Sbjct: 786 NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GRCTDVDECSSGAPP 844

Query: 414 C--QQVCVNTVGSYECQCHPGYK 434
           C     C NT GS+ C C PGY+
Sbjct: 845 CGPHGHCTNTEGSFRCSCAPGYR 867



 Score =  142 bits (358), Expect = 2e-33
 Identities = 108/334 (32%), Positives = 143/334 (42%), Gaps = 54/334 (16%)

Query: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ---GEGRQCEDIDE 89
            P G     G   DVDEC+ G   C     C NT  S++CSC PGY+   G    C D++E
Sbjct: 822  PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 881

Query: 90   CGNELNGGCVH---DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            C   L G       +CLN  G++ CTC  G+     G +CLDVDEC E +      C N 
Sbjct: 882  C---LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 938

Query: 147  MGSYECCCKEGFFLSDNQHTCIHRSEEGL-SCMNKDHGCSHICKE---APRGSVACECRP 202
             GS+EC C  G           HR+   L SC++ D      C+E   A  GS  CE  P
Sbjct: 939  DGSFECICPPG-----------HRAGPDLASCLDVDE-----CRERGPALCGSQRCENSP 982

Query: 203  GFELAKNQRDCILTCNHG-NGGCQHSCDDTAD----GPECSCHPQYKMHTDGR-SCLERE 256
            G         C+  C+ G + G + +CDD  +    GPE  C  Q   +T G   C    
Sbjct: 983  G------SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEI-CGAQRCENTPGSYRCTPAC 1035

Query: 257  DTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQL 316
            D   + T       VD     + R           G    C++      C C  G+    
Sbjct: 1036 DPGYQPTPGGGCQDVD---ECRNRSFC--------GAHAVCQNLPGSFQCLCDQGYEGAR 1084

Query: 317  DGKTCKDIDECQTRNGGCD-HFCKNIVGSFDCGC 349
            DG+ C D++EC+T  G C    C+N+ GSF C C
Sbjct: 1085 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1118



 Score =  128 bits (322), Expect = 2e-29
 Identities = 141/559 (25%), Positives = 207/559 (37%), Gaps = 114/559 (20%)

Query: 73  CKPGYQGEGRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDE 131
           C  G++     CED+DEC     G C H +C N  G Y C C DGF+L     +C+    
Sbjct: 344 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 401

Query: 132 CLE---------NNGGCQHTCVNVMGSYECCC-KEGFFLSDNQHTCIHRSEEGL------ 175
             E          +GGC    +  +    CCC + G         C     EG       
Sbjct: 402 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 461

Query: 176 ------SCMNKDHGCSHICKEAPRGSVA----------------------------CECR 201
                 S  +  +    + +E PR S++                             + R
Sbjct: 462 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPR 521

Query: 202 PGFELAKNQRDC-----ILTCNHGNGGCQHS--------CDDTADGPECSCHPQYKMHTD 248
           PG EL            I      +G CQ +        C     G  C+C   +++   
Sbjct: 522 PGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQ 581

Query: 249 GRSCLEREDT----------VLEVTESNTTSVVDGDKRVKRR----LLMETCAVNNGGCD 294
           G  C++ ++             E +  +   V     R   R    L ++ C      CD
Sbjct: 582 GTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD 641

Query: 295 -RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKG 352
              C++T     C CP G+     G +C+D+DEC    G C    CKN+ GSF C C  G
Sbjct: 642 LGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAG 701

Query: 353 FKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRGYTLYG-FTHCGDTNECSI 409
           F+    E   +DVDEC+ +   C    C N  G+F CAC  G+   G    C D +EC+ 
Sbjct: 702 FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758

Query: 410 NNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGD 468
           +   C    C NT GS++C C  G++ +    +C +V         P     C  S G  
Sbjct: 759 SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP--GQECVNSPGSF 816

Query: 469 GCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKH-SSVKESF 527
            C   C SG H               L+ G+C+  + +    G  P  P  H ++ + SF
Sbjct: 817 QC-RTCPSGHH---------------LHRGRCT--DVDECSSGAPPCGPHGHCTNTEGSF 858

Query: 528 RYVNLTCSSGKQVP-GAPG 545
           R    +C+ G + P G PG
Sbjct: 859 R---CSCAPGYRAPSGRPG 874



 Score =  127 bits (318), Expect = 7e-29
 Identities = 125/431 (29%), Positives = 169/431 (39%), Gaps = 60/431 (13%)

Query: 33   PPGRGRAAGPQE----DVDECAQGLDDCHADALCQNTPTSYKC--SCKPGYQ-GEGRQCE 85
            PPG    AGP      DVDEC +          C+N+P SY+C   C PGY  G    C+
Sbjct: 947  PPGH--RAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD 1004

Query: 86   DIDEC---GNELNGGCVHDCLNIPGNYRCT--CFDGFMLAHDGHNCLDVDECLENNG-GC 139
            D+DEC   G E+ G     C N PG+YRCT  C  G+     G  C DVDEC   +  G 
Sbjct: 1005 DVDECQEYGPEICGA--QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGA 1061

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACE 199
               C N+ GS++C C +G+  + +   C+  +E    C      C     E   GS  C 
Sbjct: 1062 HAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCV 1117

Query: 200  CRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTV 259
            C    E         +      G    S       P     P        R    R+  V
Sbjct: 1118 CPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPP-PPPLPRRPSTPRQGPV 1176

Query: 260  LEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGK 319
                         G  R  R    +T A +   CD       T   C C VG   +  G 
Sbjct: 1177 -------------GSGR--RECYFDTAAPD--ACDNILARNVTWQECCCTVG---EGWGS 1216

Query: 320  TCKDIDECQ-TRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQ-DVDECSL--DRTCD 375
             C+ I +C  T        C +          +G+   + + S + DVDEC L  D+ C 
Sbjct: 1217 GCR-IQQCPGTETAEYQSLCPH---------GRGYLAPSGDLSLRRDVDECQLFRDQVCK 1266

Query: 376  HS-CINHPGTFACACNRGYTLYGFT-HCGDTNECSINNGGCQQV-CVNTVGSYECQCHPG 432
               C+N    ++C C+ GY  +     C D +EC+     C+   CVNTVGSY C C P 
Sbjct: 1267 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPP 1326

Query: 433  YKLHWNKKDCV 443
              L  +++ CV
Sbjct: 1327 LVLDGSQRRCV 1337



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 107/430 (24%), Positives = 147/430 (34%), Gaps = 93/430 (21%)

Query: 30  GAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDE 89
           G  P G  R  G  EDVDECA G    H +  C NT   Y C C  G+            
Sbjct: 342 GPCPTGFERVNGSCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGF------------ 387

Query: 90  CGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGS 149
                          +  + R +C    +++     C  V      +GGC    +  +  
Sbjct: 388 ---------------LLDSSRSSCISQHVISEAKGPCFRV----LRDGGCSLPILRNITK 428

Query: 150 YECCC-KEGFFLSDNQHTCIHRSEEGL------------SCMNKDHGCSHICKEAPRGSV 196
             CCC + G         C     EG             S  +  +    + +E PR S+
Sbjct: 429 QICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 488

Query: 197 ACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE 256
           +   +P    A ++        H          D   GPE    P     T         
Sbjct: 489 S---QPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPL-PSIPAWTGP------- 537

Query: 257 DTVLEVTESNTTS-------VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP 309
               E+ ES  +S        V G  R   R    TCA     CD   + +  G  C   
Sbjct: 538 ----EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCA-----CDSGFRLSPQGTRC--- 585

Query: 310 VGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC- 368
                 +D   C+ +       G C+    N  GSF C C  GF+       C DVDEC 
Sbjct: 586 ------IDVDECRRVPP-PCAPGRCE----NSPGSFRCVCGPGFRAGPRAAECLDVDECH 634

Query: 369 SLDRTCD-HSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINNGGC-QQVCVNTVGS 424
            +   CD   C N PG+F C C  GY    +G   C D +EC+ + G C +  C N  GS
Sbjct: 635 RVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG-ASCQDVDECTQSPGLCGRGACKNLPGS 693

Query: 425 YECQCHPGYK 434
           + C C  G++
Sbjct: 694 FRCVCPAGFR 703



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 45/145 (31%), Positives = 61/145 (42%), Gaps = 20/145 (13%)

Query: 33   PPGRGRAAGP-----QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPG--YQGEGRQCE 85
            P GRG  A       + DVDEC    D      +C NT   Y C C  G  Y  +  +C 
Sbjct: 1236 PHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECI 1295

Query: 86   DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGG------ 138
            D DEC +E        C+N  G+Y CTC    +L      C+ +  + L++N G      
Sbjct: 1296 DNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEV 1355

Query: 139  -----CQHTCVNVMGSY-ECCCKEG 157
                 C H  ++   +Y ECCC  G
Sbjct: 1356 GADLVCSHPRLDRQATYTECCCLYG 1380



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 44/158 (27%), Positives = 62/158 (39%), Gaps = 16/158 (10%)

Query: 62   CQNTPTS-YKCSCKPGY-----QGEGRQCEDIDECGNELNGGCVHD-CLNIPGNYRCTCF 114
            C  T T+ Y+  C  G       G+     D+DEC    +  C    C+N    Y C C 
Sbjct: 1223 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1282

Query: 115  DGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEE 173
            +G+        C+D DEC +    C+   CVN +GSY C C+    L  +Q  C+    +
Sbjct: 1283 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQ 1342

Query: 174  GLS-----C---MNKDHGCSHICKEAPRGSVACECRPG 203
             L      C   +  D  CSH   +       C C  G
Sbjct: 1343 SLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1380



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 7/87 (8%)

Query: 86   DIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQH 141
            + +ECG  +  GC +  C+ +P  + C CFDG+ L      C+D++EC E       C +
Sbjct: 1533 EAEECG--ILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 142  T-CVNVMGSYECCCKEGFFLSDNQHTC 167
              C+N  GS+ C C+ GF  +   H C
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 9/103 (8%)

Query: 33   PPGRGRAAG----PQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CED 86
            PP  G  AG    P E+++    G+ D   +  C   P  + C C  GY+ +  +  C D
Sbjct: 1515 PPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574

Query: 87   IDEC--GNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNC 126
            I+EC      +  CV+  CLN  G++RC C  GF   H  H+C
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 57/205 (27%), Positives = 77/205 (37%), Gaps = 34/205 (16%)

Query: 24   PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADAL----CQN----TPTSYKCSCKP 75
            P+L      PP   R + P++       G  +C+ D      C N      T  +C C  
Sbjct: 1153 PVLPARPPPPPLPRRPSTPRQG--PVGSGRRECYFDTAAPDACDNILARNVTWQECCCTV 1210

Query: 76   GYQGEGRQCEDIDEC-GNELNGGCVHDCLNIPGNYRCTCFDGF-MLAHDGHNCL--DVDE 131
            G +G G  C  I +C G E               Y+  C  G   LA  G   L  DVDE
Sbjct: 1211 G-EGWGSGCR-IQQCPGTET------------AEYQSLCPHGRGYLAPSGDLSLRRDVDE 1256

Query: 132  C-LENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK 189
            C L  +  C+   CVN    Y C C  G++    +  CI   E    C +++  C     
Sbjct: 1257 CQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACEGGRC 1312

Query: 190  EAPRGSVACECRPGFELAKNQRDCI 214
                GS  C C P   L  +QR C+
Sbjct: 1313 VNTVGSYHCTCEPPLVLDGSQRRCV 1337



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 31/111 (27%), Positives = 43/111 (38%), Gaps = 15/111 (13%)

Query: 297  CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKL 355
            C +T+ G  C C  G+        C D DEC      C+   C N VGS+ C C+    L
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329

Query: 356  LTDEKSC-----QDVD--------ECSLDRTCDHSCINHPGTFA-CACNRG 392
               ++ C     Q +D        E   D  C H  ++   T+  C C  G
Sbjct: 1330 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1380



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 8/77 (10%)

Query: 364  DVDECS-LDRTCDHSCINHPGTFACACNRGYTLYGFTH--CGDTNECSINNGG---CQQV 417
            + +EC  LD   +  C+  P  F C C  GY L   T   C D NEC         C   
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRL-DMTRMACVDINECDEAEAASPLCVNA 1591

Query: 418  -CVNTVGSYECQCHPGY 433
             C+NT GS+ C C PG+
Sbjct: 1592 RCLNTDGSFRCICRPGF 1608



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 5/76 (6%)

Query: 323  DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC----SLDRTCDHS- 377
            + +EC   +G  +  C  +   F C C  G++L     +C D++EC    +    C ++ 
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 378  CINHPGTFACACNRGY 393
            C+N  G+F C C  G+
Sbjct: 1593 CLNTDGSFRCICRPGF 1608



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 18/118 (15%)

Query: 323 DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINH 381
           D   C  R G  +      V + D  C  GF+ +    SC+DVDEC+    C H  C N 
Sbjct: 323 DCQLCSERLGNSER-----VSAPDGPCPTGFERVNG--SCEDVDECATGGRCQHGECANT 375

Query: 382 PGTFACACNRGYTL-YGFTHCGDTNECS---------INNGGCQQVCVNTVGSYECQC 429
            G + C C  G+ L    + C   +  S         + +GGC    +  +    C C
Sbjct: 376 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCC 433



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 23/74 (31%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 284  ETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG----CDHFCK 339
            E C + +G  +  C     G  C C  G+ L +    C DI+EC           +  C 
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1594

Query: 340  NIVGSFDCGCKKGF 353
            N  GSF C C+ GF
Sbjct: 1595 NTDGSFRCICRPGF 1608



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 25/91 (27%), Positives = 37/91 (40%), Gaps = 9/91 (9%)

Query: 127  LDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186
            L+ +EC   +G     CV V   + C C +G+ L   +  C+  +E      ++    S 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE-----CDEAEAASP 1586

Query: 187  ICKEA----PRGSVACECRPGFELAKNQRDC 213
            +C  A      GS  C CRPGF        C
Sbjct: 1587 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 2/73 (2%)

Query: 403  DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGL-LPTSVSPR-VSLH 460
            +  EC I +G     CV     + C+C  GY+L   +  CV++       + SP  V+  
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 461  CGKSGGGDGCFLR 473
            C  + G   C  R
Sbjct: 1593 CLNTDGSFRCICR 1605



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 23/90 (25%), Positives = 34/90 (37%), Gaps = 1/90 (1%)

Query: 697 LCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSP 756
           +C  G   A G   CQLC+      E       PC  G    +       +C T  +C  
Sbjct: 310 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQH 369

Query: 757 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVS 786
           G   NT       CP G +  +  +++C+S
Sbjct: 370 GECANTRGGYTCVCPDG-FLLDSSRSSCIS 398



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 57/265 (21%), Positives = 85/265 (32%), Gaps = 68/265 (25%)

Query: 611 DVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERC---------ILCPNGT 661
           + A+ PP  +  + E+          QCV C  G   + A   C         + CP   
Sbjct: 755 ECARSPPPCTYGRCENT-----EGSFQCV-CPMGFQPNTAGSECEDVDECENHLACPGQE 808

Query: 662 FQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQP-GEY----SADGFAPCQLCAL 716
             N  G   C  CP   +   L      ++ EC     P G +    + +G   C  CA 
Sbjct: 809 CVNSPGSFQCRTCP---SGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCS-CAP 864

Query: 717 GTFQPEAGRTS-------------CFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTT 763
           G ++  +GR               CFP G  L T         D      C+PG+     
Sbjct: 865 G-YRAPSGRPGPCADVNECLEGDFCFPHGECLNT---------DGSFACTCAPGYRPGPR 914

Query: 764 THRCI---------RCPVGTYQPEFGKNNCVSCPGNTT-TDFDGSTNITQCKNR---RCG 810
              C+          C  G      G   C+  PG+    D     ++ +C+ R    CG
Sbjct: 915 GASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCG 974

Query: 811 GELGDFTGYIESPNYPGNYPANTEC 835
            +           N PG+Y    +C
Sbjct: 975 SQ--------RCENSPGSYRCVRDC 991


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  168 bits (425), Expect = 3e-41
 Identities = 113/366 (30%), Positives = 165/366 (45%), Gaps = 35/366 (9%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKC--SCKPGYQ--GEGRQCEDIDECGNELNGGCV 99
            +D+DECA G   CHA   C NT  SY+C   C  G++   +G  C+DI+EC  + +  C 
Sbjct: 5146 QDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC--QESSPCH 5203

Query: 100  HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC--CKEG 157
              C N  G++ C C  G+ L   G  C+DV+EC +N       C N  G Y+C   C  G
Sbjct: 5204 QRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNG 5261

Query: 158  FFLSDNQHTCIHRSEEGLSCMNKDHGCSH--ICKEAPRGSVACECRPGFELAKNQRDC-- 213
               ++N  TCI   E    C +  H C +  IC E  RGS  C C  G+      R C  
Sbjct: 5262 MTKAENG-TCIDIDE----CKDGTHQCRYNQIC-ENTRGSYRCVCPRGYRSQGVGRPCMD 5315

Query: 214  ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV-- 271
            I  C      C H C +T    +C C P   +  DG+SC   E      T+ ++ ++   
Sbjct: 5316 INECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARF 5375

Query: 272  -------DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                      +  ++   + +          +   T   +  +CP G     D  TC DI
Sbjct: 5376 SPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDI 5433

Query: 325  DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC---SLDRTCDHSCINH 381
            DEC+  +  C H CKN  GS+ C C  G++L  + K+CQD+DEC   ++    +  C N 
Sbjct: 5434 DECENTDA-CQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNM 5492

Query: 382  PGTFAC 387
             G++ C
Sbjct: 5493 RGSYQC 5498



 Score =  152 bits (383), Expect = 2e-36
 Identities = 124/440 (28%), Positives = 161/440 (36%), Gaps = 97/440 (22%)

Query: 73   CKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVD 130
            C  G+     G  C D DEC       C H C N  G Y C+C  G  +A DG  C D+D
Sbjct: 5092 CPSGFTLDSVGPFCADEDECA--AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 131  ECLENNGGCQ--HTCVNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMN-----KD 181
            EC      C     C N +GSY C   C  GF           R+ +GLSC +     + 
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGF----------RRTSDGLSCQDINECQES 5199

Query: 182  HGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPEC-SCH 240
              C   C  A  GS  C C PG++L   +   +  C          C +T  G +C    
Sbjct: 5200 SPCHQRCFNAI-GSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLC 5258

Query: 241  PQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDT 300
            P      +  +C++ ++              DG  +         C  N     + C++T
Sbjct: 5259 PNGMTKAENGTCIDIDECK------------DGTHQ---------CRYN-----QICENT 5292

Query: 301  STGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEK 360
                 C CP G+  Q  G+ C DI+EC+     C H C N  GSF C C  G  LL D K
Sbjct: 5293 RGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGK 5352

Query: 361  SCQDVDEC--------------------------------------SLDRTCDHSCINHP 382
            SC  ++                                        S  R    S     
Sbjct: 5353 SCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTR 5412

Query: 383  GTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
             T    C  G      T C D +EC  N   CQ  C NT GSY+C C PGY+L  N K C
Sbjct: 5413 RTIRKTCPEGSEASHDT-CVDIDECE-NTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470

Query: 443  VEVKGLLPTSVSPRVSLHCG 462
             ++   L  +V      HCG
Sbjct: 5471 QDIDECLEQNV------HCG 5484



 Score =  146 bits (368), Expect = 1e-34
 Identities = 122/452 (26%), Positives = 172/452 (38%), Gaps = 112/452 (24%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVH-- 100
            D DECA G    H+   C N   +Y CSC  G     +GR C+DIDEC   L     H  
Sbjct: 5107 DEDECAAGNPCSHS---CHNAMGTYYCSCPKGLTIAADGRTCQDIDECA--LGRHTCHAG 5161

Query: 101  -DCLNIPGNYRCT--CFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEG 157
             DC N  G+YRC   C  GF    DG +C D++EC E++  C   C N +GS+ C C+ G
Sbjct: 5162 QDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQRCFNAIGSFHCGCEPG 5220

Query: 158  FFLSDNQHTCIHRSEEGLSCMNKDHGCSHICK-----EAPRGSVACE--CRPGFELAKNQ 210
            + L            +G  CM+ +    ++C+     +  RG   C   C  G   A+N 
Sbjct: 5221 YQL------------KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENG 5268

Query: 211  RDC-ILTCNHGNGGCQHS--CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNT 267
                I  C  G   C+++  C++T     C C   Y+    GR C++             
Sbjct: 5269 TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD------------- 5315

Query: 268  TSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDEC 327
                           +  C      C   C +T     C CP G  L  DGK+C  ++  
Sbjct: 5316 ---------------INECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERL 5360

Query: 328  QTRNGGCDHFCKNIVG---------------------------------------SFDCG 348
               N G  +   N+                                         +    
Sbjct: 5361 P--NYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKT 5418

Query: 349  CKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTL-YGFTHCGDTNEC 407
            C +G +   D  +C D+DEC     C H C N  G++ C C  GY L +    C D +EC
Sbjct: 5419 CPEGSEASHD--TCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDEC 5476

Query: 408  SINNGGC--QQVCVNTVGSYEC---QCHPGYK 434
               N  C   ++C N  GSY+C    C P Y+
Sbjct: 5477 LEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQ 5508



 Score =  122 bits (306), Expect = 2e-27
 Identities = 70/187 (37%), Positives = 94/187 (50%), Gaps = 14/187 (7%)

Query: 308  CPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367
            CP GFTL   G  C D DEC   N  C H C N +G++ C C KG  +  D ++CQD+DE
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150

Query: 368  CSLDRTCDHS---CINHPGTFACA--CNRGY--TLYGFTHCGDTNECSINNGGCQQVCVN 420
            C+L R   H+   C N  G++ C   C  G+  T  G + C D NEC   +  C Q C N
Sbjct: 5151 CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLS-CQDINECQ-ESSPCHQRCFN 5208

Query: 421  TVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHL 480
             +GS+ C C PGY+L   K  C++V         P    HC  + GG  C   C +G+  
Sbjct: 5209 AIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRP--DQHCKNTRGGYKCIDLCPNGMTK 5264

Query: 481  SSDVTTI 487
            + + T I
Sbjct: 5265 AENGTCI 5271



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 3/38 (7%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKC---SCKPGYQ 78
            +D+DEC +    C  + +C N   SY+C    C P YQ
Sbjct: 5471 QDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQ 5508


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  164 bits (416), Expect = 3e-40
 Identities = 116/404 (28%), Positives = 178/404 (44%), Gaps = 65/404 (16%)

Query: 96  GGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYEC- 152
           G C   C +      C+CF G+ L  DG +C DV+EC+  +  C+   +C+N +GS+ C 
Sbjct: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243

Query: 153 ---CCKEGFFLS-DNQHTCIHRSEEGLSCMNKDHGC--SHICKEAPRGSVAC----ECRP 202
               C  G+ L+ DN    I   E G+      H C    IC+    GS  C    +C+ 
Sbjct: 244 RDSSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKS 296

Query: 203 GFELAKNQRDCI--LTCNHGNGGCQ--HSCDDTADGPEC-----SCHPQYKMHTDGRSCL 253
           GF +     +CI    C   +  C   H+C +T     C     +C   Y ++ +G  C+
Sbjct: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 254 EREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFT 313
           + ++                          E C     G    C ++     C C  G+ 
Sbjct: 356 DVDECAPPA---------------------EPC-----GKGHRCVNSPGSFRCECKTGYY 389

Query: 314 LQLDGKTCKDIDECQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR 372
                + C D++ECQ   G  C H C+N +GS+ C C  GF+L  D +SC+D++ECS   
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448

Query: 373 TCDHSCINHPGTFACACNRGYTLY---GFTHCGDTNECSINNGG--CQQVCVNTVGSYEC 427
            C   C N  G++ C C RGY L    G T C D +EC++  GG  C   C+N  GS++C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPGSFQC 507

Query: 428 QC-HPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C   GY+L  N ++C ++   +    +  ++  C    GG  C
Sbjct: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  149 bits (376), Expect = 1e-35
 Identities = 103/325 (31%), Positives = 141/325 (43%), Gaps = 55/325 (16%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC----SCKPGY-QGEGRQCEDIDECGNELNGGC 98
           +D+DEC  G+ +C  D +CQNT  S++C     CK G+ Q     C DI+EC   ++  C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISAPC 319

Query: 99  V--HDCLNIPGNYRC-----TCFDGFMLAHDGHNCLDVDECLENNGGC--QHTCVNVMGS 149
              H C+N  G+Y C      C  G+ L  +G  C+DVDEC      C   H CVN  GS
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMN-KDHGCSHICKEAPRGSVACECRPGFELAK 208
           + C CK G++       C+  +E    C       C H C E   GS  C C  GF L+ 
Sbjct: 380 FRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKC-ENTLGSYLCSCSVGFRLSV 434

Query: 209 NQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKM-HTDGRSCLEREDTVLEVTESNT 267
           + R C       +  C   C +     +C C   Y++   DG +C   ED          
Sbjct: 435 DGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC---ED---------- 481

Query: 268 TSVVDGDKRVKRRLLMETCAVNNGG--CDRTCKDTSTGVHCSCP-VGFTLQLDGKTCKDI 324
                          ++ CA+  GG  C   C +      CSCP  G+ L  +G+ C+DI
Sbjct: 482 ---------------IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526

Query: 325 DECQT--RNGGCDHFCKNIVGSFDC 347
           DEC T   N   +  C NI G F C
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRC 551



 Score =  131 bits (329), Expect = 4e-30
 Identities = 79/218 (36%), Positives = 107/218 (49%), Gaps = 30/218 (13%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEG--RQCEDIDECGNELNGGCVHDC 102
           DVDECA   + C     C N+P S++C CK GY  +G  R C D++EC       C H C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSD 162
            N  G+Y C+C  GF L+ DG +C D++EC  ++  C   C NV GSY+C C+ G+ LSD
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSD 473

Query: 163 NQHTCIHRSEEGLSCMNKD--------HGCSHICKEAPRGSVACEC-RPGFELAKNQRDC 213
                     +G++C + D        H CS+ C   P GS  C C   G+ LA N R+C
Sbjct: 474 ---------VDGVTCEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNC 523

Query: 214 --ILTCNHGNGGC--QHSCDDTADGPEC---SCHPQYK 244
             I  C  G   C    +C +   G  C    C   Y+
Sbjct: 524 QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561



 Score =  128 bits (321), Expect = 3e-29
 Identities = 138/509 (27%), Positives = 188/509 (36%), Gaps = 100/509 (19%)

Query: 24  PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ 83
           PLLLL G        AAG   DV      L+ C AD    +   +++  C   Y  E ++
Sbjct: 13  PLLLLGGLAL----LAAGVDADVL-----LEACCADG---HRMATHQKDCSLPYATESKE 60

Query: 84  CEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTC 143
           C  + E        C H  L         C  G  LA++   C        +N   + T 
Sbjct: 61  CRMVQE-------QCCHSQLE-----ELHCATGISLANEQDRCATPHG---DNASLEATF 105

Query: 144 VNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVAC--E 199
           V       CC  C  G        +C +    G  C      C    +E     V    E
Sbjct: 106 VK-----RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE 160

Query: 200 CRPGFELAKNQRDCILTCN-HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED- 257
                E+ + Q D  L     G G C+  C DT D   CSC   Y++ +DG SC +  + 
Sbjct: 161 TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 258 -----------------------------TVLEVTESNTTSVVDGDKRVKRRLLMETCAV 288
                                        T  E+TE N+   +D  +            +
Sbjct: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECE----------SGI 270

Query: 289 NNGGCDRTCKDTSTGVHC----SCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIV 342
           +N   D  C++T     C     C  GF     G  C DI+EC + +  C   H C N  
Sbjct: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTE 329

Query: 343 GSFDC-----GCKKGFKLLTDEKSCQDVDECSLD-RTC--DHSCINHPGTFACACNRGYT 394
           GS+ C      C +G+ L  +   C DVDEC+     C   H C+N PG+F C C  GY 
Sbjct: 330 GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 395 LYGFTH-CGDTNECSINNGG-CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTS 452
             G +  C D NEC    G  C   C NT+GSY C C  G++L  + + C ++      S
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN---ECS 446

Query: 453 VSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
            SP  S  C    G   C+  C  G  LS
Sbjct: 447 SSP-CSQECANVYGSYQCY--CRRGYQLS 472



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 100/433 (23%), Positives = 153/433 (35%), Gaps = 81/433 (18%)

Query: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKS 464
           N+     G C+Q C +T     C C  GY+L  +   C +V   +  S S R+   C  +
Sbjct: 177 NDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 465 GGGDGC--FLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPE-KHS 521
            G   C     C +G  L+ D                 S K+ +    G+   LP+    
Sbjct: 237 VGSFRCQRDSSCGTGYELTED----------------NSCKDIDECESGIHNCLPDFICQ 280

Query: 522 SVKESFR-YVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDL--SCIV 578
           +   SFR    L C SG  +  A G      E               ++A C +  +CI 
Sbjct: 281 NTLGSFRCRPKLQCKSG-FIQDALGNCIDINECL------------SISAPCPIGHTCIN 327

Query: 579 KRTEKRLRKAIRTLRKAVHREQFHLQLSGMN-LDVAKKPPRTSERQAESCGVGQGHAENQ 637
                  +K +    +      +HL   G   +DV +  P      AE CG G     ++
Sbjct: 328 TEGSYTCQKNVPNCGRG-----YHLNEEGTRCVDVDECAP-----PAEPCGKG-----HR 372

Query: 638 CVS--------CRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAW 689
           CV+        C+ G Y+DG    C+       Q   G++    C     S        +
Sbjct: 373 CVNSPGSFRCECKTGYYFDGISRMCV--DVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 690 NMSECGGLCQPGEYSADGFAPC-QLCA--LGTFQPEAGRTSCFPCGGGLATKHQGATSFQ 746
            +S  G  C+  + +    +PC Q CA   G++Q       C+   G   +   G T   
Sbjct: 431 RLSVDGRSCE--DINECSSSPCSQECANVYGSYQ-------CYCRRGYQLSDVDGVT--- 478

Query: 747 DCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCP-GNTTTDFDGS-TNITQC 804
            CE   +C+     +  ++RCI  P G++Q     +     P G    D D   T I  C
Sbjct: 479 -CEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536

Query: 805 K-NRRCGGELGDF 816
             N  C    G F
Sbjct: 537 SINETCFNIQGGF 549



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 16/66 (24%), Positives = 26/66 (39%), Gaps = 3/66 (4%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC---SCKPGYQGEGRQCEDIDECGNELNGGCVH 100
           +D+DEC  G+ +C  +  C N    ++C    C   Y+      +      N   G    
Sbjct: 524 QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKE 583

Query: 101 DCLNIP 106
           DC  +P
Sbjct: 584 DCRVLP 589


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  164 bits (416), Expect = 3e-40
 Identities = 116/404 (28%), Positives = 178/404 (44%), Gaps = 65/404 (16%)

Query: 96  GGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYEC- 152
           G C   C +      C+CF G+ L  DG +C DV+EC+  +  C+   +C+N +GS+ C 
Sbjct: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243

Query: 153 ---CCKEGFFLS-DNQHTCIHRSEEGLSCMNKDHGC--SHICKEAPRGSVAC----ECRP 202
               C  G+ L+ DN    I   E G+      H C    IC+    GS  C    +C+ 
Sbjct: 244 RDSSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKS 296

Query: 203 GFELAKNQRDCI--LTCNHGNGGCQ--HSCDDTADGPEC-----SCHPQYKMHTDGRSCL 253
           GF +     +CI    C   +  C   H+C +T     C     +C   Y ++ +G  C+
Sbjct: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 254 EREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFT 313
           + ++                          E C     G    C ++     C C  G+ 
Sbjct: 356 DVDECAPPA---------------------EPC-----GKGHRCVNSPGSFRCECKTGYY 389

Query: 314 LQLDGKTCKDIDECQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR 372
                + C D++ECQ   G  C H C+N +GS+ C C  GF+L  D +SC+D++ECS   
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448

Query: 373 TCDHSCINHPGTFACACNRGYTLY---GFTHCGDTNECSINNGG--CQQVCVNTVGSYEC 427
            C   C N  G++ C C RGY L    G T C D +EC++  GG  C   C+N  GS++C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPGSFQC 507

Query: 428 QC-HPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C   GY+L  N ++C ++   +    +  ++  C    GG  C
Sbjct: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  149 bits (376), Expect = 1e-35
 Identities = 103/325 (31%), Positives = 141/325 (43%), Gaps = 55/325 (16%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC----SCKPGY-QGEGRQCEDIDECGNELNGGC 98
           +D+DEC  G+ +C  D +CQNT  S++C     CK G+ Q     C DI+EC   ++  C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISAPC 319

Query: 99  V--HDCLNIPGNYRC-----TCFDGFMLAHDGHNCLDVDECLENNGGC--QHTCVNVMGS 149
              H C+N  G+Y C      C  G+ L  +G  C+DVDEC      C   H CVN  GS
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMN-KDHGCSHICKEAPRGSVACECRPGFELAK 208
           + C CK G++       C+  +E    C       C H C E   GS  C C  GF L+ 
Sbjct: 380 FRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKC-ENTLGSYLCSCSVGFRLSV 434

Query: 209 NQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKM-HTDGRSCLEREDTVLEVTESNT 267
           + R C       +  C   C +     +C C   Y++   DG +C   ED          
Sbjct: 435 DGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC---ED---------- 481

Query: 268 TSVVDGDKRVKRRLLMETCAVNNGG--CDRTCKDTSTGVHCSCP-VGFTLQLDGKTCKDI 324
                          ++ CA+  GG  C   C +      CSCP  G+ L  +G+ C+DI
Sbjct: 482 ---------------IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526

Query: 325 DECQT--RNGGCDHFCKNIVGSFDC 347
           DEC T   N   +  C NI G F C
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRC 551



 Score =  131 bits (329), Expect = 4e-30
 Identities = 79/218 (36%), Positives = 107/218 (49%), Gaps = 30/218 (13%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEG--RQCEDIDECGNELNGGCVHDC 102
           DVDECA   + C     C N+P S++C CK GY  +G  R C D++EC       C H C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSD 162
            N  G+Y C+C  GF L+ DG +C D++EC  ++  C   C NV GSY+C C+ G+ LSD
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSD 473

Query: 163 NQHTCIHRSEEGLSCMNKD--------HGCSHICKEAPRGSVACEC-RPGFELAKNQRDC 213
                     +G++C + D        H CS+ C   P GS  C C   G+ LA N R+C
Sbjct: 474 ---------VDGVTCEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNC 523

Query: 214 --ILTCNHGNGGC--QHSCDDTADGPEC---SCHPQYK 244
             I  C  G   C    +C +   G  C    C   Y+
Sbjct: 524 QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561



 Score =  128 bits (321), Expect = 3e-29
 Identities = 138/509 (27%), Positives = 188/509 (36%), Gaps = 100/509 (19%)

Query: 24  PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ 83
           PLLLL G        AAG   DV      L+ C AD    +   +++  C   Y  E ++
Sbjct: 13  PLLLLGGLAL----LAAGVDADVL-----LEACCADG---HRMATHQKDCSLPYATESKE 60

Query: 84  CEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTC 143
           C  + E        C H  L         C  G  LA++   C        +N   + T 
Sbjct: 61  CRMVQE-------QCCHSQLE-----ELHCATGISLANEQDRCATPHG---DNASLEATF 105

Query: 144 VNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVAC--E 199
           V       CC  C  G        +C +    G  C      C    +E     V    E
Sbjct: 106 VK-----RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE 160

Query: 200 CRPGFELAKNQRDCILTCN-HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED- 257
                E+ + Q D  L     G G C+  C DT D   CSC   Y++ +DG SC +  + 
Sbjct: 161 TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 258 -----------------------------TVLEVTESNTTSVVDGDKRVKRRLLMETCAV 288
                                        T  E+TE N+   +D  +            +
Sbjct: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECE----------SGI 270

Query: 289 NNGGCDRTCKDTSTGVHC----SCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIV 342
           +N   D  C++T     C     C  GF     G  C DI+EC + +  C   H C N  
Sbjct: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTE 329

Query: 343 GSFDC-----GCKKGFKLLTDEKSCQDVDECSLD-RTC--DHSCINHPGTFACACNRGYT 394
           GS+ C      C +G+ L  +   C DVDEC+     C   H C+N PG+F C C  GY 
Sbjct: 330 GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 395 LYGFTH-CGDTNECSINNGG-CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTS 452
             G +  C D NEC    G  C   C NT+GSY C C  G++L  + + C ++      S
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN---ECS 446

Query: 453 VSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
            SP  S  C    G   C+  C  G  LS
Sbjct: 447 SSP-CSQECANVYGSYQCY--CRRGYQLS 472



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 100/433 (23%), Positives = 153/433 (35%), Gaps = 81/433 (18%)

Query: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKS 464
           N+     G C+Q C +T     C C  GY+L  +   C +V   +  S S R+   C  +
Sbjct: 177 NDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 465 GGGDGC--FLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPE-KHS 521
            G   C     C +G  L+ D                 S K+ +    G+   LP+    
Sbjct: 237 VGSFRCQRDSSCGTGYELTED----------------NSCKDIDECESGIHNCLPDFICQ 280

Query: 522 SVKESFR-YVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDL--SCIV 578
           +   SFR    L C SG  +  A G      E               ++A C +  +CI 
Sbjct: 281 NTLGSFRCRPKLQCKSG-FIQDALGNCIDINECL------------SISAPCPIGHTCIN 327

Query: 579 KRTEKRLRKAIRTLRKAVHREQFHLQLSGMN-LDVAKKPPRTSERQAESCGVGQGHAENQ 637
                  +K +    +      +HL   G   +DV +  P      AE CG G     ++
Sbjct: 328 TEGSYTCQKNVPNCGRG-----YHLNEEGTRCVDVDECAP-----PAEPCGKG-----HR 372

Query: 638 CVS--------CRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAW 689
           CV+        C+ G Y+DG    C+       Q   G++    C     S        +
Sbjct: 373 CVNSPGSFRCECKTGYYFDGISRMCV--DVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 690 NMSECGGLCQPGEYSADGFAPC-QLCA--LGTFQPEAGRTSCFPCGGGLATKHQGATSFQ 746
            +S  G  C+  + +    +PC Q CA   G++Q       C+   G   +   G T   
Sbjct: 431 RLSVDGRSCE--DINECSSSPCSQECANVYGSYQ-------CYCRRGYQLSDVDGVT--- 478

Query: 747 DCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCP-GNTTTDFDGS-TNITQC 804
            CE   +C+     +  ++RCI  P G++Q     +     P G    D D   T I  C
Sbjct: 479 -CEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536

Query: 805 K-NRRCGGELGDF 816
             N  C    G F
Sbjct: 537 SINETCFNIQGGF 549



 Score = 30.4 bits (67), Expect = 8.7
 Identities = 11/38 (28%), Positives = 19/38 (50%), Gaps = 3/38 (7%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC---SCKPGYQ 78
           +D+DEC  G+ +C  +  C N    ++C    C   Y+
Sbjct: 524 QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  164 bits (416), Expect = 3e-40
 Identities = 116/404 (28%), Positives = 178/404 (44%), Gaps = 65/404 (16%)

Query: 96  GGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYEC- 152
           G C   C +      C+CF G+ L  DG +C DV+EC+  +  C+   +C+N +GS+ C 
Sbjct: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243

Query: 153 ---CCKEGFFLS-DNQHTCIHRSEEGLSCMNKDHGC--SHICKEAPRGSVAC----ECRP 202
               C  G+ L+ DN    I   E G+      H C    IC+    GS  C    +C+ 
Sbjct: 244 RDSSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKS 296

Query: 203 GFELAKNQRDCI--LTCNHGNGGCQ--HSCDDTADGPEC-----SCHPQYKMHTDGRSCL 253
           GF +     +CI    C   +  C   H+C +T     C     +C   Y ++ +G  C+
Sbjct: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 254 EREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFT 313
           + ++                          E C     G    C ++     C C  G+ 
Sbjct: 356 DVDECAPPA---------------------EPC-----GKGHRCVNSPGSFRCECKTGYY 389

Query: 314 LQLDGKTCKDIDECQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR 372
                + C D++ECQ   G  C H C+N +GS+ C C  GF+L  D +SC+D++ECS   
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448

Query: 373 TCDHSCINHPGTFACACNRGYTLY---GFTHCGDTNECSINNGG--CQQVCVNTVGSYEC 427
            C   C N  G++ C C RGY L    G T C D +EC++  GG  C   C+N  GS++C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPGSFQC 507

Query: 428 QC-HPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C   GY+L  N ++C ++   +    +  ++  C    GG  C
Sbjct: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  150 bits (379), Expect = 6e-36
 Identities = 109/366 (29%), Positives = 155/366 (42%), Gaps = 61/366 (16%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC----SCKPGY-QGEGRQCEDIDECGNELNGGC 98
           +D+DEC  G+ +C  D +CQNT  S++C     CK G+ Q     C DI+EC   ++  C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISAPC 319

Query: 99  V--HDCLNIPGNYRC-----TCFDGFMLAHDGHNCLDVDECLENNGGC--QHTCVNVMGS 149
              H C+N  G+Y C      C  G+ L  +G  C+DVDEC      C   H CVN  GS
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMN-KDHGCSHICKEAPRGSVACECRPGFELAK 208
           + C CK G++       C+  +E    C       C H C E   GS  C C  GF L+ 
Sbjct: 380 FRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKC-ENTLGSYLCSCSVGFRLSV 434

Query: 209 NQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKM-HTDGRSCLEREDTVLEVTESNT 267
           + R C       +  C   C +     +C C   Y++   DG +C   ED          
Sbjct: 435 DGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC---ED---------- 481

Query: 268 TSVVDGDKRVKRRLLMETCAVNNGG--CDRTCKDTSTGVHCSCP-VGFTLQLDGKTCKDI 324
                          ++ CA+  GG  C   C +      CSCP  G+ L  +G+ C+DI
Sbjct: 482 ---------------IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526

Query: 325 DECQT--RNGGCDHFCKNIVGSFDC---GCKKGFKLLTDEKSCQDVDECSLDRTC---DH 376
           DEC T   N   +  C NI G F C    C + ++        +  D     ++C   D 
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDV 586

Query: 377 SCINHP 382
           +C+  P
Sbjct: 587 TCVFDP 592



 Score =  128 bits (321), Expect = 3e-29
 Identities = 138/509 (27%), Positives = 188/509 (36%), Gaps = 100/509 (19%)

Query: 24  PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ 83
           PLLLL G        AAG   DV      L+ C AD    +   +++  C   Y  E ++
Sbjct: 13  PLLLLGGLAL----LAAGVDADVL-----LEACCADG---HRMATHQKDCSLPYATESKE 60

Query: 84  CEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTC 143
           C  + E        C H  L         C  G  LA++   C        +N   + T 
Sbjct: 61  CRMVQE-------QCCHSQLE-----ELHCATGISLANEQDRCATPHG---DNASLEATF 105

Query: 144 VNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVAC--E 199
           V       CC  C  G        +C +    G  C      C    +E     V    E
Sbjct: 106 VK-----RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE 160

Query: 200 CRPGFELAKNQRDCILTCN-HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED- 257
                E+ + Q D  L     G G C+  C DT D   CSC   Y++ +DG SC +  + 
Sbjct: 161 TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 258 -----------------------------TVLEVTESNTTSVVDGDKRVKRRLLMETCAV 288
                                        T  E+TE N+   +D  +            +
Sbjct: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECE----------SGI 270

Query: 289 NNGGCDRTCKDTSTGVHC----SCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIV 342
           +N   D  C++T     C     C  GF     G  C DI+EC + +  C   H C N  
Sbjct: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTE 329

Query: 343 GSFDC-----GCKKGFKLLTDEKSCQDVDECSLD-RTC--DHSCINHPGTFACACNRGYT 394
           GS+ C      C +G+ L  +   C DVDEC+     C   H C+N PG+F C C  GY 
Sbjct: 330 GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 395 LYGFTH-CGDTNECSINNGG-CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTS 452
             G +  C D NEC    G  C   C NT+GSY C C  G++L  + + C ++      S
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN---ECS 446

Query: 453 VSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
            SP  S  C    G   C+  C  G  LS
Sbjct: 447 SSP-CSQECANVYGSYQCY--CRRGYQLS 472



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 100/433 (23%), Positives = 153/433 (35%), Gaps = 81/433 (18%)

Query: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKS 464
           N+     G C+Q C +T     C C  GY+L  +   C +V   +  S S R+   C  +
Sbjct: 177 NDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 465 GGGDGC--FLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPE-KHS 521
            G   C     C +G  L+ D                 S K+ +    G+   LP+    
Sbjct: 237 VGSFRCQRDSSCGTGYELTED----------------NSCKDIDECESGIHNCLPDFICQ 280

Query: 522 SVKESFR-YVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDL--SCIV 578
           +   SFR    L C SG  +  A G      E               ++A C +  +CI 
Sbjct: 281 NTLGSFRCRPKLQCKSG-FIQDALGNCIDINECL------------SISAPCPIGHTCIN 327

Query: 579 KRTEKRLRKAIRTLRKAVHREQFHLQLSGMN-LDVAKKPPRTSERQAESCGVGQGHAENQ 637
                  +K +    +      +HL   G   +DV +  P      AE CG G     ++
Sbjct: 328 TEGSYTCQKNVPNCGRG-----YHLNEEGTRCVDVDECAP-----PAEPCGKG-----HR 372

Query: 638 CVS--------CRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAW 689
           CV+        C+ G Y+DG    C+       Q   G++    C     S        +
Sbjct: 373 CVNSPGSFRCECKTGYYFDGISRMCV--DVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 690 NMSECGGLCQPGEYSADGFAPC-QLCA--LGTFQPEAGRTSCFPCGGGLATKHQGATSFQ 746
            +S  G  C+  + +    +PC Q CA   G++Q       C+   G   +   G T   
Sbjct: 431 RLSVDGRSCE--DINECSSSPCSQECANVYGSYQ-------CYCRRGYQLSDVDGVT--- 478

Query: 747 DCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCP-GNTTTDFDGS-TNITQC 804
            CE   +C+     +  ++RCI  P G++Q     +     P G    D D   T I  C
Sbjct: 479 -CEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536

Query: 805 K-NRRCGGELGDF 816
             N  C    G F
Sbjct: 537 SINETCFNIQGGF 549


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  164 bits (416), Expect = 3e-40
 Identities = 116/404 (28%), Positives = 178/404 (44%), Gaps = 65/404 (16%)

Query: 96  GGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ--HTCVNVMGSYEC- 152
           G C   C +      C+CF G+ L  DG +C DV+EC+  +  C+   +C+N +GS+ C 
Sbjct: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243

Query: 153 ---CCKEGFFLS-DNQHTCIHRSEEGLSCMNKDHGC--SHICKEAPRGSVAC----ECRP 202
               C  G+ L+ DN    I   E G+      H C    IC+    GS  C    +C+ 
Sbjct: 244 RDSSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKS 296

Query: 203 GFELAKNQRDCI--LTCNHGNGGCQ--HSCDDTADGPEC-----SCHPQYKMHTDGRSCL 253
           GF +     +CI    C   +  C   H+C +T     C     +C   Y ++ +G  C+
Sbjct: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 254 EREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFT 313
           + ++                          E C     G    C ++     C C  G+ 
Sbjct: 356 DVDECAPPA---------------------EPC-----GKGHRCVNSPGSFRCECKTGYY 389

Query: 314 LQLDGKTCKDIDECQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR 372
                + C D++ECQ   G  C H C+N +GS+ C C  GF+L  D +SC+D++ECS   
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448

Query: 373 TCDHSCINHPGTFACACNRGYTLY---GFTHCGDTNECSINNGG--CQQVCVNTVGSYEC 427
            C   C N  G++ C C RGY L    G T C D +EC++  GG  C   C+N  GS++C
Sbjct: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPGSFQC 507

Query: 428 QC-HPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C   GY+L  N ++C ++   +    +  ++  C    GG  C
Sbjct: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  150 bits (378), Expect = 8e-36
 Identities = 108/354 (30%), Positives = 151/354 (42%), Gaps = 62/354 (17%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKC----SCKPGY-QGEGRQCEDIDECGNELNGGC 98
           +D+DEC  G+ +C  D +CQNT  S++C     CK G+ Q     C DI+EC   ++  C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISAPC 319

Query: 99  V--HDCLNIPGNYRC-----TCFDGFMLAHDGHNCLDVDECLENNGGC--QHTCVNVMGS 149
              H C+N  G+Y C      C  G+ L  +G  C+DVDEC      C   H CVN  GS
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMN-KDHGCSHICKEAPRGSVACECRPGFELAK 208
           + C CK G++       C+  +E    C       C H C E   GS  C C  GF L+ 
Sbjct: 380 FRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKC-ENTLGSYLCSCSVGFRLSV 434

Query: 209 NQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKM-HTDGRSCLEREDTVLEVTESNT 267
           + R C       +  C   C +     +C C   Y++   DG +C   ED          
Sbjct: 435 DGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC---ED---------- 481

Query: 268 TSVVDGDKRVKRRLLMETCAVNNGG--CDRTCKDTSTGVHCSCP-VGFTLQLDGKTCKDI 324
                          ++ CA+  GG  C   C +      CSCP  G+ L  +G+ C+DI
Sbjct: 482 ---------------IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526

Query: 325 DECQT--RNGGCDHFCKNIVGSFDC---GCKKGFK----LLTDEKSCQDVDECS 369
           DEC T   N   +  C NI G F C    C + ++       +   C +  ECS
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  128 bits (321), Expect = 3e-29
 Identities = 138/509 (27%), Positives = 188/509 (36%), Gaps = 100/509 (19%)

Query: 24  PLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ 83
           PLLLL G        AAG   DV      L+ C AD    +   +++  C   Y  E ++
Sbjct: 13  PLLLLGGLAL----LAAGVDADVL-----LEACCADG---HRMATHQKDCSLPYATESKE 60

Query: 84  CEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTC 143
           C  + E        C H  L         C  G  LA++   C        +N   + T 
Sbjct: 61  CRMVQE-------QCCHSQLE-----ELHCATGISLANEQDRCATPHG---DNASLEATF 105

Query: 144 VNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVAC--E 199
           V       CC  C  G        +C +    G  C      C    +E     V    E
Sbjct: 106 VK-----RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE 160

Query: 200 CRPGFELAKNQRDCILTCN-HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED- 257
                E+ + Q D  L     G G C+  C DT D   CSC   Y++ +DG SC +  + 
Sbjct: 161 TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 258 -----------------------------TVLEVTESNTTSVVDGDKRVKRRLLMETCAV 288
                                        T  E+TE N+   +D  +            +
Sbjct: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECE----------SGI 270

Query: 289 NNGGCDRTCKDTSTGVHC----SCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIV 342
           +N   D  C++T     C     C  GF     G  C DI+EC + +  C   H C N  
Sbjct: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTE 329

Query: 343 GSFDC-----GCKKGFKLLTDEKSCQDVDECSLD-RTC--DHSCINHPGTFACACNRGYT 394
           GS+ C      C +G+ L  +   C DVDEC+     C   H C+N PG+F C C  GY 
Sbjct: 330 GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 395 LYGFTH-CGDTNECSINNGG-CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTS 452
             G +  C D NEC    G  C   C NT+GSY C C  G++L  + + C ++      S
Sbjct: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN---ECS 446

Query: 453 VSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
            SP  S  C    G   C+  C  G  LS
Sbjct: 447 SSP-CSQECANVYGSYQCY--CRRGYQLS 472



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 100/433 (23%), Positives = 153/433 (35%), Gaps = 81/433 (18%)

Query: 405 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKS 464
           N+     G C+Q C +T     C C  GY+L  +   C +V   +  S S R+   C  +
Sbjct: 177 NDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 465 GGGDGC--FLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPE-KHS 521
            G   C     C +G  L+ D                 S K+ +    G+   LP+    
Sbjct: 237 VGSFRCQRDSSCGTGYELTED----------------NSCKDIDECESGIHNCLPDFICQ 280

Query: 522 SVKESFR-YVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDL--SCIV 578
           +   SFR    L C SG  +  A G      E               ++A C +  +CI 
Sbjct: 281 NTLGSFRCRPKLQCKSG-FIQDALGNCIDINECL------------SISAPCPIGHTCIN 327

Query: 579 KRTEKRLRKAIRTLRKAVHREQFHLQLSGMN-LDVAKKPPRTSERQAESCGVGQGHAENQ 637
                  +K +    +      +HL   G   +DV +  P      AE CG G     ++
Sbjct: 328 TEGSYTCQKNVPNCGRG-----YHLNEEGTRCVDVDECAP-----PAEPCGKG-----HR 372

Query: 638 CVS--------CRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAW 689
           CV+        C+ G Y+DG    C+       Q   G++    C     S        +
Sbjct: 373 CVNSPGSFRCECKTGYYFDGISRMCV--DVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

Query: 690 NMSECGGLCQPGEYSADGFAPC-QLCA--LGTFQPEAGRTSCFPCGGGLATKHQGATSFQ 746
            +S  G  C+  + +    +PC Q CA   G++Q       C+   G   +   G T   
Sbjct: 431 RLSVDGRSCE--DINECSSSPCSQECANVYGSYQ-------CYCRRGYQLSDVDGVT--- 478

Query: 747 DCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCP-GNTTTDFDGS-TNITQC 804
            CE   +C+     +  ++RCI  P G++Q     +     P G    D D   T I  C
Sbjct: 479 -CEDIDECALPTGGHICSYRCINIP-GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536

Query: 805 K-NRRCGGELGDF 816
             N  C    G F
Sbjct: 537 SINETCFNIQGGF 549


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score =  157 bits (397), Expect = 5e-38
 Identities = 205/838 (24%), Positives = 303/838 (36%), Gaps = 168/838 (20%)

Query: 32   VPPGRGR---AAGPQEDVDECAQGLDDC-HADALCQNTPTSYKCSCKPGYQG--EGRQCE 85
            +PP R     A     + DEC    + C H +  C   P  Y C C PGY+   + R C 
Sbjct: 558  LPPSRSAVEIAPTQVTETDECRLNQNICGHGE--CVPGPPDYSCHCNPGYRSHPQHRYCV 615

Query: 86   DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML--AHDGHNCLDVDEC----LENNGGC 139
            D++EC  E  G     C+N  G+Y C C  G+ L     G +C+D++EC    L  +GG 
Sbjct: 616  DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG- 674

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACE 199
               C+N  G Y+C C  G+ L  ++       +E   C +        C+  P       
Sbjct: 675  --FCINFPGHYKCNCYPGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIA 729

Query: 200  CRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED 257
            C+PG+  ++    C  +  C  G+      C++      C+C   Y    DGRSC     
Sbjct: 730  CQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC----- 783

Query: 258  TVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLD 317
              L+V E     V D                 NG     C +T     C C  G+ L  D
Sbjct: 784  --LDVDECEAGDVCD-----------------NG----ICSNTPGSFQCQCLSGYHLSRD 820

Query: 318  GKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC--- 374
               C+DIDEC          C N  GS+ C C +G +L+   K CQD+DECS D +    
Sbjct: 821  RSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLP 879

Query: 375  DHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYK 434
              +C N  G++ C C+ G+T     H            GC++V          Q H   +
Sbjct: 880  HGACKNLQGSYVCVCDEGFTPTQDQH------------GCEEV---------EQPHHKKE 918

Query: 435  LHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFK 494
             + N  D V    +L T+V+ +       +G GD C +     ++ S++  ++       
Sbjct: 919  CYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEI-YPCPVYSSAEFHSL------- 970

Query: 495  LNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMF 554
              +GK   ++  +   G+ PA    H  + E   + +  C  GK V   PG     K+ F
Sbjct: 971  CPDGKGYTQDNNIVNYGI-PA----HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGF 1025

Query: 555  ITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAK 614
                  LE    +        C+    E   R  +    +  +R              A 
Sbjct: 1026 YYDGNLLECVDVD-------ECL---DESNCRNGVCENTRGGYR-------------CAC 1062

Query: 615  KPPRTSERQAESCGVGQGHAENQC---VSCRAGTYYDGARERCILCPNGTFQNEEGQMTC 671
             PP         C   +    ++C    +CR G        RC+  P G+++ E     C
Sbjct: 1063 TPPAEYSPAQRQCLSPEEMDVDECQDPAACRPG--------RCVNLP-GSYRCE-----C 1108

Query: 672  EPCPRPGNSG---------ALKTPE----AWNMSECGGLCQPGEYSADGFAPCQLCALGT 718
             P   PG SG         A + PE     W+     G+C  G  +         C    
Sbjct: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC-AGPLAGPALTFDDCCCR-- 1165

Query: 719  FQPEAGRTSCFPC-----GGGLATKHQGATSFQDCETRVQCSPGHFYNTT---THRCIRC 770
             Q       C PC     G    T    + SF D    +   P    +++   +  C RC
Sbjct: 1166 -QGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC-RC 1223

Query: 771  PVGTYQPEFGKNNCVSCPGN--------TTTDFDGSTNITQ----CKNRRCGGELGDF 816
              G   P  G   C  CPG            D D    + Q    CK+ RC    G F
Sbjct: 1224 VSGRCVPRPGGAVC-ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280



 Score =  100 bits (250), Expect = 5e-21
 Identities = 119/463 (25%), Positives = 157/463 (33%), Gaps = 89/463 (19%)

Query: 33   PPGRGRAAGPQ-EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDID- 88
            P G     G + +D+DEC+Q    C     C+N   SY C C  G+     Q  CE+++ 
Sbjct: 853  PQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912

Query: 89   ----------------------------ECGNELNGGCVHDCLNIP------GNYRCTCF 114
                                        EC   L  G    C   P        +   C 
Sbjct: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972

Query: 115  DGFMLAHDGHNC-------LDVDEC-LENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQH 165
            DG     D +          D+DEC L  +  C+   CVN    YEC CK+GF+   N  
Sbjct: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLL 1032

Query: 166  TCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQ 225
             C+   E    C+++ +  + +C E  RG   C C P  E +  QR C+         CQ
Sbjct: 1033 ECVDVDE----CLDESNCRNGVC-ENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087

Query: 226  HS-------CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278
                     C +      C C P +     GR C   E       E         D    
Sbjct: 1088 DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERR-------DVCWS 1140

Query: 279  RRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG--CDH 336
            +R     CA    G   T  D      C C  G      G  C+    C  R  G  C  
Sbjct: 1141 QRGEDGMCAGPLAGPALTFDD------CCCRQGRGW---GAQCRP---CPPRGAGSHCPT 1188

Query: 337  FCKNIVGSFDCGCKKGFKLLTDEKSCQ-DVDECSLDRTCDHSCINHPGTFACACNRGYTL 395
                    +D       K   DE S + D DEC   R     C+  PG   C C  G+ L
Sbjct: 1189 SQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC---RCVSGRCVPRPGGAVCECPGGFQL 1245

Query: 396  YGF-THCGDTNEC-SINNGGC---QQVCVNTVGSYECQCHPGY 433
                  C D +EC  +N  G     + CVNT GS+ C C  G+
Sbjct: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 93/372 (25%), Positives = 142/372 (38%), Gaps = 52/372 (13%)

Query: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDN 163
           + G     C  G+   +  H C D++EC    G C+H  C+N  GSY C C  G  L  +
Sbjct: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPS 390

Query: 164 QHTCI-HRSEEGLSC---MNKDHGCSH-----------ICKEAPRGSVACECRPGFELAK 208
           +  CI  + EE   C   ++ +H C H            C         C+  P    A 
Sbjct: 391 RTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450

Query: 209 NQRDC-------ILTCNHG---NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDT 258
            +  C       ILT +      G    S     DGP     P+ +   +  S     + 
Sbjct: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP-----PKPQQLPESPSQAPPPED 505

Query: 259 VLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSC----PVGFTL 314
             E     T S V  ++ V++     T        +   + +   +        P    +
Sbjct: 506 TEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAV 565

Query: 315 QLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT 373
           ++      + DEC+     C H  C      + C C  G++     + C DV+EC  +  
Sbjct: 566 EIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-P 624

Query: 374 CDHS---CINHPGTFACACNRGYTLY---GFTHCGDTNECS----INNGGCQQVCVNTVG 423
           C      C+N  G++ C CNRGY L+   G   C D NEC+      +GG    C+N  G
Sbjct: 625 CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPG 681

Query: 424 SYECQCHPGYKL 435
            Y+C C+PGY+L
Sbjct: 682 HYKCNCYPGYRL 693



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 89/309 (28%), Positives = 109/309 (35%), Gaps = 36/309 (11%)

Query: 86   DIDEC---GNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH 141
            DIDEC   G+E+   C    C+N    Y C C  GF    +   C+DVDECL+ +     
Sbjct: 993  DIDECMLFGSEI---CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049

Query: 142  TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH-ICKEAPRGSVACEC 200
             C N  G Y C C      S  Q  C+   E  +        C    C   P GS  CEC
Sbjct: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP-GSYRCEC 1108

Query: 201  RPGFELAKNQRDCILTCNHGNGG--------CQHSCDDTADGP---------ECSCHPQY 243
            RP +    + RDC L  +              Q   D    GP         +C C    
Sbjct: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGR 1168

Query: 244  KMHTDGRSCLER---EDTVLEVTESNT---TSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
                  R C  R          +ESN+   TS +   K  +     E  +         C
Sbjct: 1169 GWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1228

Query: 298  KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG---C-DHFCKNIVGSFDCGCKKGF 353
                 G  C CP GF L      C DIDEC+  N     C    C N  GSF C CK GF
Sbjct: 1229 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288

Query: 354  KLLTDEKSC 362
                   +C
Sbjct: 1289 ARSRPHGAC 1297



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 35/89 (39%), Positives = 40/89 (44%), Gaps = 11/89 (12%)

Query: 85   EDIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLE-NNGGC--- 139
            ED DEC       CV   C+  PG   C C  GF L      C+D+DEC E N  G    
Sbjct: 1216 EDSDECR------CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK 1269

Query: 140  QHTCVNVMGSYECCCKEGFFLSDNQHTCI 168
               CVN  GS+ C CK GF  S     C+
Sbjct: 1270 SERCVNTSGSFRCVCKAGFARSRPHGACV 1298



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 114/517 (22%), Positives = 170/517 (32%), Gaps = 87/517 (16%)

Query: 343 GSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS-CINHPGTFACACNRGYTLYGFTHC 401
           G     C +G+K L +   CQD++EC++   C H  C+N+PG++ C C  G++L      
Sbjct: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL-----G 388

Query: 402 GDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHC 461
               +C  +    + +C   V S E QC         ++ C         SV       C
Sbjct: 389 PSRTQCIADKPEEKSLCFRLV-SPEHQCQHPLTTRLTRQLCC-------CSVGKAWGARC 440

Query: 462 GK-SGGGDGCFLR-CHSG----IHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPA 515
            +    G   F   C +G    I  S    TI+    F L          +  PE    A
Sbjct: 441 QRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQA 500

Query: 516 LP----------------EKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEF 559
            P                 +  SV++S  +   T +  +  P    RPS P   +   + 
Sbjct: 501 PPPEDTEEERGVTTDSPVSEERSVQQS--HPTATTTPARPYPELISRPSPPTMRWFLPDL 558

Query: 560 ELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHRE---QFHLQLSGMNLDVAKKP 616
               +  E+      + + +  E RL + I    + V        H      +    +  
Sbjct: 559 PPSRSAVEIAP----TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYC 614

Query: 617 PRTSERQAESCGVGQGHAEN-----QCVSCRAGTYYDGARER-CI---------LCPNGT 661
              +E +AE CG G+G   N      C   R    + GA  R C+         LC +G 
Sbjct: 615 VDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG 674

Query: 662 F-QNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQ 720
           F  N  G   C  C       A + P   ++ EC     P             C  G  +
Sbjct: 675 FCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECR---DPSS-----------CPDGKCE 719

Query: 721 PEAGRTSCFPCGGGLATKHQGA-TSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEF 779
            + G   C  C  G  ++  GA     +C     CSPG   N        C  G Y P  
Sbjct: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQG-YAPAP 778

Query: 780 GKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDF 816
              +C+        D D       C N  C    G F
Sbjct: 779 DGRSCL--------DVDECEAGDVCDNGICSNTPGSF 807



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/95 (34%), Positives = 41/95 (43%), Gaps = 12/95 (12%)

Query: 73  CKPGYQG-EGRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCL-DV 129
           C  GY+      C+DI+EC   + G C H DCLN PG+YRC C  G  L      C+ D 
Sbjct: 341 CPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 130 DE-------CLENNGGCQHTCVNVMGSYECCCKEG 157
            E        +     CQH     +    CCC  G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 15/34 (44%), Positives = 20/34 (58%), Gaps = 2/34 (5%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY 77
           +D++ECA      H D  C N P SY+C C PG+
Sbjct: 354 QDINECAMPGVCRHGD--CLNNPGSYRCVCPPGH 385


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score =  154 bits (389), Expect = 4e-37
 Identities = 108/380 (28%), Positives = 157/380 (41%), Gaps = 55/380 (14%)

Query: 83  QCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDEC-LENNGGCQ 140
           Q  + DEC    N  C H +C+  P +Y C C  G+        C+DV+EC  E  G  +
Sbjct: 571 QVTETDECRLNQNI-CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629

Query: 141 HTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN-----KDHGCSH--ICKEAPR 193
             C+N  GSY C C  G+ L        H    G SC++     K H C     C   P 
Sbjct: 630 GICMNTGGSYNCHCNRGYRL--------HVGAGGRSCVDLNECAKPHLCGDGGFCINFP- 680

Query: 194 GSVACECRPGFELAKNQR---DCILTCNHGNGGCQHSCDDTADGPEC-SCHPQYKMHTDG 249
           G   C C PG+ L  ++    + I  C   +      C++     +C +C P Y+    G
Sbjct: 681 GHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG 740

Query: 250 RSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP 309
            +C +                            +  CA  +      C++      C+C 
Sbjct: 741 -ACRD----------------------------VNECAEGSPCSPGWCENLPGSFRCTCA 771

Query: 310 VGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS 369
            G+    DG++C D+DEC+  +   +  C N  GSF C C  G+ L  D   C+D+DEC 
Sbjct: 772 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD 831

Query: 370 LDRTC-DHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGC--QQVCVNTVGSYE 426
               C    CIN  G++ C C +G+ L G   C D +ECS +   C     C N  GSY 
Sbjct: 832 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV 891

Query: 427 CQCHPGYKLHWNKKDCVEVK 446
           C C  G+    ++  C EV+
Sbjct: 892 CVCDEGFTPTQDQHGCEEVE 911



 Score =  153 bits (387), Expect = 7e-37
 Identities = 123/428 (28%), Positives = 173/428 (40%), Gaps = 65/428 (15%)

Query: 32  VPPGRGR---AAGPQEDVDECAQGLDDC-HADALCQNTPTSYKCSCKPGYQG--EGRQCE 85
           +PP R     A     + DEC    + C H +  C   P  Y C C PGY+   + R C 
Sbjct: 558 LPPSRSAVEIAPTQVTETDECRLNQNICGHGE--CVPGPPDYSCHCNPGYRSHPQHRYCV 615

Query: 86  DIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML--AHDGHNCLDVDEC----LENNGGC 139
           D++EC  E  G     C+N  G+Y C C  G+ L     G +C+D++EC    L  +GG 
Sbjct: 616 DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG- 674

Query: 140 QHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACE 199
              C+N  G Y+C C  G+ L  ++       +E   C +        C+  P       
Sbjct: 675 --FCINFPGHYKCNCYPGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIA 729

Query: 200 CRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED 257
           C+PG+  ++    C  +  C  G+      C++      C+C   Y    DGRSC     
Sbjct: 730 CQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC----- 783

Query: 258 TVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLD 317
             L+V E     V D                 NG     C +T     C C  G+ L  D
Sbjct: 784 --LDVDECEAGDVCD-----------------NG----ICSNTPGSFQCQCLSGYHLSRD 820

Query: 318 GKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC--- 374
              C+DIDEC          C N  GS+ C C +G +L+   K CQD+DECS D +    
Sbjct: 821 RSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLP 879

Query: 375 DHSCINHPGTFACACNRGYTLYGFTH-CGDT------NECSINNGG---CQQVCVNTVGS 424
             +C N  G++ C C+ G+T     H C +        EC +N      C  V    V  
Sbjct: 880 HGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQ 939

Query: 425 YECQCHPG 432
            EC C  G
Sbjct: 940 QECCCSLG 947



 Score =  140 bits (354), Expect = 5e-33
 Identities = 115/392 (29%), Positives = 166/392 (42%), Gaps = 53/392 (13%)

Query: 33   PPGRGRAAGPQ--EDVDECAQGLDDCHADALCQNTPTSYKC-SCKPGYQGEGR-QCEDID 88
            P  R +A+ P   ED+DEC      C  D  C+N P S+KC +C+PGY+ +G   C D++
Sbjct: 689  PGYRLKASRPPVCEDIDECRDP-SSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746

Query: 89   EC--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNV 146
            EC  G+  + G    C N+PG++RCTC  G+  A DG +CLDVDEC   +      C N 
Sbjct: 747  ECAEGSPCSPGW---CENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNT 803

Query: 147  MGSYECCCKEGFFLSDNQHTCIHRSE-------EGLSCMNKDHGCSHICKEAPRGSVACE 199
             GS++C C  G+ LS ++  C    E        G  C+N +     +C +  R     +
Sbjct: 804  PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK 863

Query: 200  CRPGFELAKNQRDCIL--TCNHGNGGCQHSCDD--TADGPECSCHPQYKMHTDGRSCLER 255
            C+   E +++   C+    C +  G     CD+  T    +  C    + H      L  
Sbjct: 864  CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF 923

Query: 256  EDTVL--EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCK------DTSTGVHCS 307
            +DTV    V  +N T               E C     G    C+       +S   H  
Sbjct: 924  DDTVFCDSVLATNVTQ-------------QECCCSLGAGWGDHCEIYPCPVYSSAEFHSL 970

Query: 308  CPVGFTLQLDGKTC-------KDIDECQTRNGGC--DHFCKNIVGSFDCGCKKGFKLLTD 358
            CP G     D           +DIDEC         +  C N    ++C CK+GF    +
Sbjct: 971  CPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGN 1030

Query: 359  EKSCQDVDECSLDRTCDHS-CINHPGTFACAC 389
               C DVDEC  +  C +  C N  G + CAC
Sbjct: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062



 Score =  125 bits (315), Expect = 2e-28
 Identities = 125/508 (24%), Positives = 183/508 (36%), Gaps = 121/508 (23%)

Query: 31   AVPPG-RGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG--EGRQCEDI 87
            A  PG R +  G   DV+ECA+G   C +   C+N P S++C+C  GY    +GR C D+
Sbjct: 729  ACQPGYRSQGGGACRDVNECAEG-SPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV 786

Query: 88   DEC--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVN 145
            DEC  G+  + G    C N PG+++C C  G+ L+ D  +C D+DEC          C+N
Sbjct: 787  DECEAGDVCDNGI---CSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCIN 843

Query: 146  VMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH---------ICKEAPRGSV 196
              GSY C C +G           HR   G  C + D  CS           CK   +GS 
Sbjct: 844  TNGSYRCLCPQG-----------HRLVGGRKCQDIDE-CSQDPSLCLPHGACKNL-QGSY 890

Query: 197  ACECRPGFELAKNQRDCI-LTCNHGNGGCQHSCDDTA----------DGPECSCH----- 240
             C C  GF   ++Q  C  +   H    C  + DDT              EC C      
Sbjct: 891  VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW 950

Query: 241  ---------PQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNG 291
                     P Y        C + +    +    N    +   + +   +L  +     G
Sbjct: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG--IPAHRDIDECMLFGSEICKEG 1008

Query: 292  GCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKK 351
                 C +T  G  C C  GF    +   C D+DEC   +   +  C+N  G + C C  
Sbjct: 1009 ----KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP 1064

Query: 352  GFKLLTDEKSCQDVDE----------CSLDRTCDHSCINHPG----TFACACNRGYTLYG 397
              +    ++ C   +E          C   R  D  C         TF   C R    +G
Sbjct: 1065 PAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWG 1124

Query: 398  F-----------THC-----------------------------GDTNECSINNGGCQQV 417
                        +HC                              D++EC   +G     
Sbjct: 1125 AQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR---- 1180

Query: 418  CVNTVGSYECQCHPGYKLHWNKKDCVEV 445
            CV   G   C+C  G++L  ++  CV++
Sbjct: 1181 CVPRPGGAVCECPGGFQLDASRARCVDI 1208



 Score =  111 bits (277), Expect = 4e-24
 Identities = 85/292 (29%), Positives = 116/292 (39%), Gaps = 42/292 (14%)

Query: 201 RPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGP---ECSCHPQYKMHTDGRSCLERED 257
           R   E+A  Q      C      C H   +   GP    C C+P Y+ H   R C++   
Sbjct: 562 RSAVEIAPTQVTETDECRLNQNICGHG--ECVPGPPDYSCHCNPGYRSHPQHRYCVD--- 616

Query: 258 TVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLD 317
               V E                   E C    G     C +T    +C C  G+ L + 
Sbjct: 617 ----VNECEA----------------EPCGPGRG----ICMNTGGSYNCHCNRGYRLHVG 652

Query: 318 --GKTCKDIDECQTRN-GGCDHFCKNIVGSFDCGCKKGFKLLTDEKS-CQDVDECSLDRT 373
             G++C D++EC   +  G   FC N  G + C C  G++L       C+D+DEC    +
Sbjct: 653 AGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSS 712

Query: 374 C-DHSCINHPGTFAC-ACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHP 431
           C D  C N PG+F C AC  GY   G   C D NEC+  +      C N  GS+ C C  
Sbjct: 713 CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQ 772

Query: 432 GYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSD 483
           GY    + + C++V       V       C  + G   C  +C SG HLS D
Sbjct: 773 GYAPAPDGRSCLDVDECEAGDVCDNGI--CSNTPGSFQC--QCLSGYHLSRD 820



 Score =  108 bits (271), Expect = 2e-23
 Identities = 119/481 (24%), Positives = 165/481 (34%), Gaps = 129/481 (26%)

Query: 30   GAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDI 87
            G  P   GR+     DVDEC  G  D   + +C NTP S++C C  GY    +   CEDI
Sbjct: 773  GYAPAPDGRSC---LDVDECEAG--DVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827

Query: 88   DECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLEN------NGGC- 139
            DEC  +    C+  DC+N  G+YRC C  G  L   G  C D+DEC ++      +G C 
Sbjct: 828  DEC--DFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACK 884

Query: 140  -------------------QHTCVNV--------------------------MGSYECCC 154
                               QH C  V                          +   ECCC
Sbjct: 885  NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCC 944

Query: 155  KEGFFLSDNQ--HTC-IHRSEE--------------------GLSCMNKDHGC----SHI 187
              G    D+   + C ++ S E                    G+        C    S I
Sbjct: 945  SLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004

Query: 188  CKEAP----RGSVACECRPGFELAKNQRDCILT--CNHGNGGCQHSCDDTADGPECSCHP 241
            CKE      +    C C+ GF    N  +C+    C   +      C++T  G  C+C P
Sbjct: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP 1064

Query: 242  QYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKR------RLLMETCAVNNG---G 292
              +     R CL  E+        +      G+  +         L  + C    G   G
Sbjct: 1065 PAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWG 1124

Query: 293  CD-RTCKDTSTGVHCSCP--------------VGFTLQLDGKTCKDIDECQTRNGGCDHF 337
               R C     G HC                 +G   + +  + +D DEC+  +G C   
Sbjct: 1125 AQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC--- 1181

Query: 338  CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC----SLDRTC-DHSCINHPGTFACACNRG 392
                 G   C C  GF+L      C D+DEC         C    C+N  G+F C C  G
Sbjct: 1182 -VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1240

Query: 393  Y 393
            +
Sbjct: 1241 F 1241



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 93/372 (25%), Positives = 142/372 (38%), Gaps = 52/372 (13%)

Query: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDN 163
           + G     C  G+   +  H C D++EC    G C+H  C+N  GSY C C  G  L  +
Sbjct: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPS 390

Query: 164 QHTCI-HRSEEGLSC---MNKDHGCSH-----------ICKEAPRGSVACECRPGFELAK 208
           +  CI  + EE   C   ++ +H C H            C         C+  P    A 
Sbjct: 391 RTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450

Query: 209 NQRDC-------ILTCNHG---NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDT 258
            +  C       ILT +      G    S     DGP     P+ +   +  S     + 
Sbjct: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGP-----PKPQQLPESPSQAPPPED 505

Query: 259 VLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSC----PVGFTL 314
             E     T S V  ++ V++     T        +   + +   +        P    +
Sbjct: 506 TEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAV 565

Query: 315 QLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT 373
           ++      + DEC+     C H  C      + C C  G++     + C DV+EC  +  
Sbjct: 566 EIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-P 624

Query: 374 CDHS---CINHPGTFACACNRGYTLY---GFTHCGDTNECS----INNGGCQQVCVNTVG 423
           C      C+N  G++ C CNRGY L+   G   C D NEC+      +GG    C+N  G
Sbjct: 625 CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPG 681

Query: 424 SYECQCHPGYKL 435
            Y+C C+PGY+L
Sbjct: 682 HYKCNCYPGYRL 693



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 79/286 (27%), Positives = 101/286 (35%), Gaps = 37/286 (12%)

Query: 86   DIDEC---GNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH 141
            DIDEC   G+E+   C    C+N    Y C C  GF    +   C+DVDECL+ +     
Sbjct: 993  DIDECMLFGSEI---CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049

Query: 142  TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECR 201
             C N  G Y C C      S  Q  C+   E   +   +D     +C  + RG       
Sbjct: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD-----VC-WSQRGEDGMCAG 1103

Query: 202  PGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVL- 260
            P    A    DC      G G     C     G  C         ++  S  +    +L 
Sbjct: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCP-----TSQSESNSFWDTSPLLLG 1158

Query: 261  EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320
            +      +S  D D+          C   +G     C     G  C CP GF L      
Sbjct: 1159 KPPRDEDSSEEDSDE----------CRCVSG----RCVPRPGGAVCECPGGFQLDASRAR 1204

Query: 321  CKDIDECQTRNGG---C-DHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
            C DIDEC+  N     C    C N  GSF C CK GF       +C
Sbjct: 1205 CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 35/89 (39%), Positives = 41/89 (46%), Gaps = 11/89 (12%)

Query: 85   EDIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG---CQ 140
            ED DEC       CV   C+  PG   C C  GF L      C+D+DEC E N     C+
Sbjct: 1169 EDSDECR------CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK 1222

Query: 141  -HTCVNVMGSYECCCKEGFFLSDNQHTCI 168
               CVN  GS+ C CK GF  S     C+
Sbjct: 1223 SERCVNTSGSFRCVCKAGFARSRPHGACV 1251



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 114/517 (22%), Positives = 170/517 (32%), Gaps = 87/517 (16%)

Query: 343 GSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS-CINHPGTFACACNRGYTLYGFTHC 401
           G     C +G+K L +   CQD++EC++   C H  C+N+PG++ C C  G++L      
Sbjct: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL-----G 388

Query: 402 GDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHC 461
               +C  +    + +C   V S E QC         ++ C         SV       C
Sbjct: 389 PSRTQCIADKPEEKSLCFRLV-SPEHQCQHPLTTRLTRQLCC-------CSVGKAWGARC 440

Query: 462 GK-SGGGDGCFLR-CHSG----IHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPA 515
            +    G   F   C +G    I  S    TI+    F L          +  PE    A
Sbjct: 441 QRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQA 500

Query: 516 LP----------------EKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEF 559
            P                 +  SV++S  +   T +  +  P    RPS P   +   + 
Sbjct: 501 PPPEDTEEERGVTTDSPVSEERSVQQS--HPTATTTPARPYPELISRPSPPTMRWFLPDL 558

Query: 560 ELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHRE---QFHLQLSGMNLDVAKKP 616
               +  E+      + + +  E RL + I    + V        H      +    +  
Sbjct: 559 PPSRSAVEIAP----TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYC 614

Query: 617 PRTSERQAESCGVGQGHAEN-----QCVSCRAGTYYDGARER-CI---------LCPNGT 661
              +E +AE CG G+G   N      C   R    + GA  R C+         LC +G 
Sbjct: 615 VDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG 674

Query: 662 F-QNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQ 720
           F  N  G   C  C       A + P   ++ EC     P             C  G  +
Sbjct: 675 FCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECR---DPSS-----------CPDGKCE 719

Query: 721 PEAGRTSCFPCGGGLATKHQGA-TSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEF 779
            + G   C  C  G  ++  GA     +C     CSPG   N        C  G Y P  
Sbjct: 720 NKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQG-YAPAP 778

Query: 780 GKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDF 816
              +C+        D D       C N  C    G F
Sbjct: 779 DGRSCL--------DVDECEAGDVCDNGICSNTPGSF 807



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/95 (34%), Positives = 41/95 (43%), Gaps = 12/95 (12%)

Query: 73  CKPGYQG-EGRQCEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCL-DV 129
           C  GY+      C+DI+EC   + G C H DCLN PG+YRC C  G  L      C+ D 
Sbjct: 341 CPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 130 DE-------CLENNGGCQHTCVNVMGSYECCCKEG 157
            E        +     CQH     +    CCC  G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 37.0 bits (84), Expect = 0.093
 Identities = 59/232 (25%), Positives = 73/232 (31%), Gaps = 55/232 (23%)

Query: 635  ENQCVS--------CRAGTYYDGARERCI---------LCPNGTFQNEEGQMTCEPCP-- 675
            E +CV+        C+ G YYDG    C+          C NG  +N  G   C   P  
Sbjct: 1007 EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA 1066

Query: 676  --RPGNSGALKTPEAWNMSECGGLC--QPGEYSADGFAPCQLCALG-TF------QPEAG 724
               P     L   E     E   +C  Q GE   DG     L     TF      Q    
Sbjct: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGE---DGMCAGPLAGPALTFDDCCCRQGRGW 1123

Query: 725  RTSCFPC-----GGGLATKHQGATSFQDCETRVQCSPGHFYNTT---THRCIRCPVGTYQ 776
               C PC     G    T    + SF D    +   P    +++   +  C RC  G   
Sbjct: 1124 GAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC-RCVSGRCV 1182

Query: 777  PEFGKNNCVSCPGN--------TTTDFDGSTNITQ----CKNRRCGGELGDF 816
            P  G   C  CPG            D D    + Q    CK+ RC    G F
Sbjct: 1183 PRPGGAVC-ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1233



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 15/34 (44%), Positives = 20/34 (58%), Gaps = 2/34 (5%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY 77
           +D++ECA      H D  C N P SY+C C PG+
Sbjct: 354 QDINECAMPGVCRHGD--CLNNPGSYRCVCPPGH 385


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  148 bits (374), Expect = 2e-35
 Identities = 114/375 (30%), Positives = 156/375 (41%), Gaps = 53/375 (14%)

Query: 73   CKPGYQ--GEGRQCEDIDECGNELNGG---CVHDCLNIPGNYRCTCFDGFMLAHDGHNCL 127
            C  G++   +G  C D DEC    +GG   C H CLN PG + CTC  GF LA D  NC 
Sbjct: 3428 CPEGFELDSQGAFCVDRDEC----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR 3483

Query: 128  DVDECLENNGGCQ--HTCVNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHG 183
            DVDEC  +   C+    CVN++GSY C   C  GF ++D         E+   C+     
Sbjct: 3484 DVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA-----GCEDVDECLEGLDD 3538

Query: 184  C--SHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSC 239
            C  + +C+  P G   C C  G+ +      C  +  C      C + C +      C C
Sbjct: 3539 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 3597

Query: 240  HPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKD 299
             P   +  DG++C     T LE    N T+V     R      +   A   G        
Sbjct: 3598 PPGQTLLRDGKAC-----TSLERNGQNVTTV---SHRGPLLPWLRPWASIPGTSYHAWVS 3649

Query: 300  TSTGV-------HCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKG 352
               G           CP GF  Q     C D+DEC+ RN  C H C+N  GS+ C C  G
Sbjct: 3650 LRPGPMALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAG 3706

Query: 353  FKLLTDEKSCQDVDEC---SLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSI 409
            ++LL   K+CQD++EC   S++      C N  G++ C           T C  T     
Sbjct: 3707 YRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGP 3757

Query: 410  NNGGCQQVCVNTVGS 424
            + G C + C    G+
Sbjct: 3758 SPGTCFRRCSQDCGT 3772



 Score =  122 bits (307), Expect = 1e-27
 Identities = 96/323 (29%), Positives = 135/323 (41%), Gaps = 41/323 (12%)

Query: 45   DVDECAQGLDDC-HADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHD 101
            D DEC+ G   C HA   C N P  + C+C  G+    + R C D+DEC  + +  C   
Sbjct: 3443 DRDECSGGPSPCSHA---CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAH-LCREG 3498

Query: 102  --CLNIPGNYRC--TCFDGFMLAHDGHNCLDVDECLENNGGCQHT--CVNVMGSYECCCK 155
              C+N+ G+YRC   C  GF +A DG  C DVDECLE    C +   C N  G + C C 
Sbjct: 3499 QRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCP 3557

Query: 156  EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213
             G+ +      C+  +E    C+     C++ C    +GS  C C PG  L ++ + C  
Sbjct: 3558 RGYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTS 3612

Query: 214  -------ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESN 266
                   + T +H  G         A  P  S H    +   G   L             
Sbjct: 3613 LERNGQNVTTVSH-RGPLLPWLRPWASIPGTSYHAWVSLR-PGPMALSSVGRAWCPPGFI 3670

Query: 267  TTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
              + V  D        ++ C V N  C   C++T     C CP G+ L   GK C+DI+E
Sbjct: 3671 RQNGVCTD--------LDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINE 3721

Query: 327  CQTRNGGC--DHFCKNIVGSFDC 347
            C+  +  C     C N  GS+ C
Sbjct: 3722 CEEESIECGPGQMCFNTRGSYQC 3744



 Score =  120 bits (300), Expect = 8e-27
 Identities = 99/353 (28%), Positives = 140/353 (39%), Gaps = 66/353 (18%)

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
            E  C EGF L      C+ R E    C      CSH C  AP G  +C C  GF LA + 
Sbjct: 3425 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 3479

Query: 211  RDC--ILTCNHGNGGCQHS--CDDTADGPEC--SCHPQYKMHTDGRSCLEREDTVLEVTE 264
            R+C  +  C      C+    C +      C   C P +++  DG  C E  D  LE   
Sbjct: 3480 RNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGC-EDVDECLEG-- 3535

Query: 265  SNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                              ++ C  N     + C++T  G  CSCP G+ +Q     C D+
Sbjct: 3536 ------------------LDDCHYN-----QLCENTPGGHRCSCPRGYRMQGPSLPCLDV 3572

Query: 325  DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDE----------------- 367
            +EC      C + C N+ GS+ C C  G  LL D K+C  ++                  
Sbjct: 3573 NECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPW 3632

Query: 368  ----CSLDRTCDHSCIN-HPGTFA-CACNRGYTLYGFTH----CGDTNECSINNGGCQQV 417
                 S+  T  H+ ++  PG  A  +  R +   GF      C D +EC + N  CQ  
Sbjct: 3633 LRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRN-LCQHA 3691

Query: 418  CVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C NT GSY+C C  GY+L  + K+C ++      S+       C  + G   C
Sbjct: 3692 CRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3744



 Score =  100 bits (249), Expect = 7e-21
 Identities = 72/220 (32%), Positives = 92/220 (41%), Gaps = 41/220 (18%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHD 101
            EDVDEC +GLDDCH + LC+NTP  ++CSC  GY  QG    C D++EC  +L   C + 
Sbjct: 3527 EDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC-LQLPKACAYQ 3585

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161
            C N+ G+YRC C  G  L  DG  C      LE NG                        
Sbjct: 3586 CHNLQGSYRCLCPPGQTLLRDGKACTS----LERNG------------------------ 3617

Query: 162  DNQHTCIHRSE--EGLSCMNKDHGCS-HICKEAPRGSVACE------CRPGFELAKNQRD 212
             N  T  HR      L       G S H       G +A        C PGF        
Sbjct: 3618 QNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCT 3677

Query: 213  CILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
             +  C   N  CQH+C +T    +C C   Y++   G++C
Sbjct: 3678 DLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNC 3716



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 39/108 (36%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 9    PGAAWAVLLLLLLLPPLLLLAGAV--PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTP 66
            PG ++   + L   P  L   G    PPG  R  G   D+DEC       HA   C+NT 
Sbjct: 3640 PGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA---CRNTE 3696

Query: 67   TSYKCSCKPGYQ--GEGRQCEDIDECGNE-LNGGCVHDCLNIPGNYRC 111
             SY+C C  GY+    G+ C+DI+EC  E +  G    C N  G+Y+C
Sbjct: 3697 GSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3744


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  148 bits (374), Expect = 2e-35
 Identities = 114/375 (30%), Positives = 156/375 (41%), Gaps = 53/375 (14%)

Query: 73   CKPGYQ--GEGRQCEDIDECGNELNGG---CVHDCLNIPGNYRCTCFDGFMLAHDGHNCL 127
            C  G++   +G  C D DEC    +GG   C H CLN PG + CTC  GF LA D  NC 
Sbjct: 4619 CPEGFELDSQGAFCVDRDEC----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR 4674

Query: 128  DVDECLENNGGCQ--HTCVNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHG 183
            DVDEC  +   C+    CVN++GSY C   C  GF ++D         E+   C+     
Sbjct: 4675 DVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA-----GCEDVDECLEGLDD 4729

Query: 184  C--SHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSC 239
            C  + +C+  P G   C C  G+ +      C  +  C      C + C +      C C
Sbjct: 4730 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 4788

Query: 240  HPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKD 299
             P   +  DG++C     T LE    N T+V     R      +   A   G        
Sbjct: 4789 PPGQTLLRDGKAC-----TSLERNGQNVTTV---SHRGPLLPWLRPWASIPGTSYHAWVS 4840

Query: 300  TSTGV-------HCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKG 352
               G           CP GF  Q     C D+DEC+ RN  C H C+N  GS+ C C  G
Sbjct: 4841 LRPGPMALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAG 4897

Query: 353  FKLLTDEKSCQDVDEC---SLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSI 409
            ++LL   K+CQD++EC   S++      C N  G++ C           T C  T     
Sbjct: 4898 YRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGP 4948

Query: 410  NNGGCQQVCVNTVGS 424
            + G C + C    G+
Sbjct: 4949 SPGTCFRRCSQDCGT 4963



 Score =  122 bits (307), Expect = 1e-27
 Identities = 96/323 (29%), Positives = 135/323 (41%), Gaps = 41/323 (12%)

Query: 45   DVDECAQGLDDC-HADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHD 101
            D DEC+ G   C HA   C N P  + C+C  G+    + R C D+DEC  + +  C   
Sbjct: 4634 DRDECSGGPSPCSHA---CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAH-LCREG 4689

Query: 102  --CLNIPGNYRC--TCFDGFMLAHDGHNCLDVDECLENNGGCQHT--CVNVMGSYECCCK 155
              C+N+ G+YRC   C  GF +A DG  C DVDECLE    C +   C N  G + C C 
Sbjct: 4690 QRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCP 4748

Query: 156  EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213
             G+ +      C+  +E    C+     C++ C    +GS  C C PG  L ++ + C  
Sbjct: 4749 RGYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTS 4803

Query: 214  -------ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESN 266
                   + T +H  G         A  P  S H    +   G   L             
Sbjct: 4804 LERNGQNVTTVSH-RGPLLPWLRPWASIPGTSYHAWVSLR-PGPMALSSVGRAWCPPGFI 4861

Query: 267  TTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
              + V  D        ++ C V N  C   C++T     C CP G+ L   GK C+DI+E
Sbjct: 4862 RQNGVCTD--------LDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINE 4912

Query: 327  CQTRNGGC--DHFCKNIVGSFDC 347
            C+  +  C     C N  GS+ C
Sbjct: 4913 CEEESIECGPGQMCFNTRGSYQC 4935



 Score =  120 bits (300), Expect = 8e-27
 Identities = 99/353 (28%), Positives = 140/353 (39%), Gaps = 66/353 (18%)

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
            E  C EGF L      C+ R E    C      CSH C  AP G  +C C  GF LA + 
Sbjct: 4616 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 4670

Query: 211  RDC--ILTCNHGNGGCQHS--CDDTADGPEC--SCHPQYKMHTDGRSCLEREDTVLEVTE 264
            R+C  +  C      C+    C +      C   C P +++  DG  C E  D  LE   
Sbjct: 4671 RNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGC-EDVDECLEG-- 4726

Query: 265  SNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                              ++ C  N     + C++T  G  CSCP G+ +Q     C D+
Sbjct: 4727 ------------------LDDCHYN-----QLCENTPGGHRCSCPRGYRMQGPSLPCLDV 4763

Query: 325  DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDE----------------- 367
            +EC      C + C N+ GS+ C C  G  LL D K+C  ++                  
Sbjct: 4764 NECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPW 4823

Query: 368  ----CSLDRTCDHSCIN-HPGTFA-CACNRGYTLYGFTH----CGDTNECSINNGGCQQV 417
                 S+  T  H+ ++  PG  A  +  R +   GF      C D +EC + N  CQ  
Sbjct: 4824 LRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRN-LCQHA 4882

Query: 418  CVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C NT GSY+C C  GY+L  + K+C ++      S+       C  + G   C
Sbjct: 4883 CRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 4935



 Score =  100 bits (249), Expect = 7e-21
 Identities = 72/220 (32%), Positives = 92/220 (41%), Gaps = 41/220 (18%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHD 101
            EDVDEC +GLDDCH + LC+NTP  ++CSC  GY  QG    C D++EC  +L   C + 
Sbjct: 4718 EDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC-LQLPKACAYQ 4776

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161
            C N+ G+YRC C  G  L  DG  C      LE NG                        
Sbjct: 4777 CHNLQGSYRCLCPPGQTLLRDGKACTS----LERNG------------------------ 4808

Query: 162  DNQHTCIHRSE--EGLSCMNKDHGCS-HICKEAPRGSVACE------CRPGFELAKNQRD 212
             N  T  HR      L       G S H       G +A        C PGF        
Sbjct: 4809 QNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCT 4868

Query: 213  CILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
             +  C   N  CQH+C +T    +C C   Y++   G++C
Sbjct: 4869 DLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNC 4907



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 39/108 (36%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 9    PGAAWAVLLLLLLLPPLLLLAGAV--PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTP 66
            PG ++   + L   P  L   G    PPG  R  G   D+DEC       HA   C+NT 
Sbjct: 4831 PGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA---CRNTE 4887

Query: 67   TSYKCSCKPGYQ--GEGRQCEDIDECGNE-LNGGCVHDCLNIPGNYRC 111
             SY+C C  GY+    G+ C+DI+EC  E +  G    C N  G+Y+C
Sbjct: 4888 GSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 4935


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  148 bits (374), Expect = 2e-35
 Identities = 114/375 (30%), Positives = 156/375 (41%), Gaps = 53/375 (14%)

Query: 73   CKPGYQ--GEGRQCEDIDECGNELNGG---CVHDCLNIPGNYRCTCFDGFMLAHDGHNCL 127
            C  G++   +G  C D DEC    +GG   C H CLN PG + CTC  GF LA D  NC 
Sbjct: 3337 CPEGFELDSQGAFCVDRDEC----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR 3392

Query: 128  DVDECLENNGGCQ--HTCVNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSCMNKDHG 183
            DVDEC  +   C+    CVN++GSY C   C  GF ++D         E+   C+     
Sbjct: 3393 DVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA-----GCEDVDECLEGLDD 3447

Query: 184  C--SHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSC 239
            C  + +C+  P G   C C  G+ +      C  +  C      C + C +      C C
Sbjct: 3448 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 3506

Query: 240  HPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKD 299
             P   +  DG++C     T LE    N T+V     R      +   A   G        
Sbjct: 3507 PPGQTLLRDGKAC-----TSLERNGQNVTTV---SHRGPLLPWLRPWASIPGTSYHAWVS 3558

Query: 300  TSTGV-------HCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKG 352
               G           CP GF  Q     C D+DEC+ RN  C H C+N  GS+ C C  G
Sbjct: 3559 LRPGPMALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAG 3615

Query: 353  FKLLTDEKSCQDVDEC---SLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSI 409
            ++LL   K+CQD++EC   S++      C N  G++ C           T C  T     
Sbjct: 3616 YRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGP 3666

Query: 410  NNGGCQQVCVNTVGS 424
            + G C + C    G+
Sbjct: 3667 SPGTCFRRCSQDCGT 3681



 Score =  122 bits (307), Expect = 1e-27
 Identities = 96/323 (29%), Positives = 135/323 (41%), Gaps = 41/323 (12%)

Query: 45   DVDECAQGLDDC-HADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHD 101
            D DEC+ G   C HA   C N P  + C+C  G+    + R C D+DEC  + +  C   
Sbjct: 3352 DRDECSGGPSPCSHA---CLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAH-LCREG 3407

Query: 102  --CLNIPGNYRC--TCFDGFMLAHDGHNCLDVDECLENNGGCQHT--CVNVMGSYECCCK 155
              C+N+ G+YRC   C  GF +A DG  C DVDECLE    C +   C N  G + C C 
Sbjct: 3408 QRCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCP 3466

Query: 156  EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213
             G+ +      C+  +E    C+     C++ C    +GS  C C PG  L ++ + C  
Sbjct: 3467 RGYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTS 3521

Query: 214  -------ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESN 266
                   + T +H  G         A  P  S H    +   G   L             
Sbjct: 3522 LERNGQNVTTVSH-RGPLLPWLRPWASIPGTSYHAWVSLR-PGPMALSSVGRAWCPPGFI 3579

Query: 267  TTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDE 326
              + V  D        ++ C V N  C   C++T     C CP G+ L   GK C+DI+E
Sbjct: 3580 RQNGVCTD--------LDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINE 3630

Query: 327  CQTRNGGC--DHFCKNIVGSFDC 347
            C+  +  C     C N  GS+ C
Sbjct: 3631 CEEESIECGPGQMCFNTRGSYQC 3653



 Score =  120 bits (300), Expect = 8e-27
 Identities = 99/353 (28%), Positives = 140/353 (39%), Gaps = 66/353 (18%)

Query: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
            E  C EGF L      C+ R E    C      CSH C  AP G  +C C  GF LA + 
Sbjct: 3334 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 3388

Query: 211  RDC--ILTCNHGNGGCQHS--CDDTADGPEC--SCHPQYKMHTDGRSCLEREDTVLEVTE 264
            R+C  +  C      C+    C +      C   C P +++  DG  C E  D  LE   
Sbjct: 3389 RNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRV-ADGAGC-EDVDECLEG-- 3444

Query: 265  SNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDI 324
                              ++ C  N     + C++T  G  CSCP G+ +Q     C D+
Sbjct: 3445 ------------------LDDCHYN-----QLCENTPGGHRCSCPRGYRMQGPSLPCLDV 3481

Query: 325  DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDE----------------- 367
            +EC      C + C N+ GS+ C C  G  LL D K+C  ++                  
Sbjct: 3482 NECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPW 3541

Query: 368  ----CSLDRTCDHSCIN-HPGTFA-CACNRGYTLYGFTH----CGDTNECSINNGGCQQV 417
                 S+  T  H+ ++  PG  A  +  R +   GF      C D +EC + N  CQ  
Sbjct: 3542 LRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRN-LCQHA 3600

Query: 418  CVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGC 470
            C NT GSY+C C  GY+L  + K+C ++      S+       C  + G   C
Sbjct: 3601 CRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3653



 Score =  100 bits (249), Expect = 7e-21
 Identities = 72/220 (32%), Positives = 92/220 (41%), Gaps = 41/220 (18%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHD 101
            EDVDEC +GLDDCH + LC+NTP  ++CSC  GY  QG    C D++EC  +L   C + 
Sbjct: 3436 EDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC-LQLPKACAYQ 3494

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161
            C N+ G+YRC C  G  L  DG  C      LE NG                        
Sbjct: 3495 CHNLQGSYRCLCPPGQTLLRDGKACTS----LERNG------------------------ 3526

Query: 162  DNQHTCIHRSE--EGLSCMNKDHGCS-HICKEAPRGSVACE------CRPGFELAKNQRD 212
             N  T  HR      L       G S H       G +A        C PGF        
Sbjct: 3527 QNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCT 3586

Query: 213  CILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
             +  C   N  CQH+C +T    +C C   Y++   G++C
Sbjct: 3587 DLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNC 3625



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 39/108 (36%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 9    PGAAWAVLLLLLLLPPLLLLAGAV--PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTP 66
            PG ++   + L   P  L   G    PPG  R  G   D+DEC       HA   C+NT 
Sbjct: 3549 PGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHA---CRNTE 3605

Query: 67   TSYKCSCKPGYQ--GEGRQCEDIDECGNE-LNGGCVHDCLNIPGNYRC 111
             SY+C C  GY+    G+ C+DI+EC  E +  G    C N  G+Y+C
Sbjct: 3606 GSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3653


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  142 bits (359), Expect = 1e-33
 Identities = 84/221 (38%), Positives = 103/221 (46%), Gaps = 17/221 (7%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLN 104
           DVDECA     C+   +C NT   Y CSC  GY     QC DIDEC     G C   C N
Sbjct: 127 DVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC---RYGYCQQLCAN 183

Query: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQ 164
           +PG+Y CTC  GF L  DG +C DV+EC   N  C  TCVN  GS+ C C  G+ L ++ 
Sbjct: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEEDG 242

Query: 165 HTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNG 222
             C    E    C   +  C H C   P G+  C C PG+ L  + R C  I  C H N 
Sbjct: 243 VHCSDMDE----CSFSEFLCQHECVNQP-GTYFCSCPPGYILLDDNRSCQDINECEHRNH 297

Query: 223 GC--QHSCDDTADGPEC----SCHPQYKMHTDGRSCLERED 257
            C  Q +C +   G +C     C   Y   +D R     E+
Sbjct: 298 TCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAEN 338



 Score =  142 bits (357), Expect = 2e-33
 Identities = 76/197 (38%), Positives = 106/197 (53%), Gaps = 9/197 (4%)

Query: 283 METCAVNNGGCDRT--CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKN 340
           ++ CA ++  C+ T  C +T  G  CSC  G+ L L+G+ C DIDEC  R G C   C N
Sbjct: 128 VDECATDSHQCNPTQICINTEGGYTCSCTDGYWL-LEGQ-CLDIDEC--RYGYCQQLCAN 183

Query: 341 IVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTL-YGFT 399
           + GS+ C C  GF L  D +SCQDV+EC+ +  C  +C+N  G+F C C+ GY L     
Sbjct: 184 VPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGV 243

Query: 400 HCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSL 459
           HC D +ECS +   CQ  CVN  G+Y C C PGY L  + + C ++      + +  +  
Sbjct: 244 HCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQ 303

Query: 460 HCGKSGGGDGCF--LRC 474
            C    GG  C   +RC
Sbjct: 304 TCYNLQGGFKCIDPIRC 320



 Score =  136 bits (343), Expect = 9e-32
 Identities = 101/368 (27%), Positives = 137/368 (37%), Gaps = 95/368 (25%)

Query: 102 CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHT--CVNVMGSYECC------ 153
           CL  PGN +  C +GF L      CLD+DEC      C+    CVN  G Y C       
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 154 -------------------------------------CKEGFFLSDNQHTCIHRSEEGLS 176
                                                C+ G+ + D  + C+   E    
Sbjct: 76  YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDE---- 130

Query: 177 CMNKDHGCS--HICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADG 234
           C    H C+   IC     G   C C  G+ L + Q   I  C +G   CQ  C +    
Sbjct: 131 CATDSHQCNPTQICINT-EGGYTCSCTDGYWLLEGQCLDIDECRYGY--CQQLCANVPGS 187

Query: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
             C+C+P + ++ DGRSC +                            +  CA  N  C 
Sbjct: 188 YSCTCNPGFTLNEDGRSCQD----------------------------VNECATEN-PCV 218

Query: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFK 354
           +TC +T     C C  G+ L+ DG  C D+DEC      C H C N  G++ C C  G+ 
Sbjct: 219 QTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYI 278

Query: 355 LLTDEKSCQDVDECS-LDRTCD--HSCINHPGTFAC----ACNRGYTLYGFTHCGDTNEC 407
           LL D +SCQD++EC   + TC+   +C N  G F C     C   Y       C     C
Sbjct: 279 LLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC----MC 334

Query: 408 SINNGGCQ 415
              N GC+
Sbjct: 335 PAENPGCR 342



 Score =  120 bits (301), Expect = 6e-27
 Identities = 67/190 (35%), Positives = 97/190 (51%), Gaps = 24/190 (12%)

Query: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDC 102
           D+DEC  G    +   LC N P SY C+C PG+    +GR C+D++EC  E    CV  C
Sbjct: 168 DIDECRYG----YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATE--NPCVQTC 221

Query: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSD 162
           +N  G++ C C  G+ L  DG +C D+DEC  +   CQH CVN  G+Y C C  G+ L D
Sbjct: 222 VNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLD 281

Query: 163 NQHTCIHRSEEGLSCMNKDHGCS--HICKEAPRG-----SVACECRPGFELAKNQRDCIL 215
           +  +C   +E    C +++H C+    C     G      + CE  P   ++ N+  C+ 
Sbjct: 282 DNRSCQDINE----CEHRNHTCNLQQTCYNLQGGFKCIDPIRCE-EPYLRISDNR--CM- 333

Query: 216 TCNHGNGGCQ 225
            C   N GC+
Sbjct: 334 -CPAENPGCR 342



 Score =  119 bits (298), Expect = 1e-26
 Identities = 80/262 (30%), Positives = 106/262 (40%), Gaps = 57/262 (21%)

Query: 38  RAAGPQEDVDECAQGLDDCHADALCQNTPTSYKC-------------------------- 71
           R +G   D+DEC    + C  D +C N    Y C                          
Sbjct: 35  RQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPA 94

Query: 72  -----------------SCKPGYQ-GEGRQCEDIDECGNELNG-GCVHDCLNIPGNYRCT 112
                             C+ GYQ  E  QC D+DEC  + +       C+N  G Y C+
Sbjct: 95  AAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCS 154

Query: 113 CFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE 172
           C DG+ L      CLD+DEC    G CQ  C NV GSY C C  GF L+++  +C   +E
Sbjct: 155 CTDGYWLLEG--QCLDIDEC--RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNE 210

Query: 173 EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDD 230
               C   ++ C   C     GS  C C PG+EL ++   C  +  C+     CQH C +
Sbjct: 211 ----CAT-ENPCVQTCVNT-YGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVN 264

Query: 231 TADGPECSCHPQYKMHTDGRSC 252
                 CSC P Y +  D RSC
Sbjct: 265 QPGTYFCSCPPGYILLDDNRSC 286



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 67/235 (28%), Positives = 91/235 (38%), Gaps = 57/235 (24%)

Query: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIVGSFDCG------ 348
           C  +       C  GF L      C DIDEC+T    C  D  C N  G + C       
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 349 -------------------------------------CKKGFKLLTDEKSCQDVDECSLD 371
                                                C+ G+++  +   C DVDEC+ D
Sbjct: 76  YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATD 134

Query: 372 -RTCDHS--CINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQ 428
              C+ +  CIN  G + C+C  GY L     C D +EC    G CQQ+C N  GSY C 
Sbjct: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLE-GQCLDIDEC--RYGYCQQLCANVPGSYSCT 191

Query: 429 CHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSD 483
           C+PG+ L+ + + C +V      + +P V   C  + G   C  RC  G  L  D
Sbjct: 192 CNPGFTLNEDGRSCQDVNEC--ATENPCVQT-CVNTYGSFIC--RCDPGYELEED 241


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  139 bits (350), Expect = 1e-32
 Identities = 127/408 (31%), Positives = 171/408 (41%), Gaps = 84/408 (20%)

Query: 49  CAQGLDDCHADALCQN-------TPTSYKCSCKPGYQGEGRQCEDIDECGNE--LNGGCV 99
           C   LD+      C+N       T T YKC C PG+   G+ C+  D C +    NGG  
Sbjct: 98  CLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGW--SGKSCQQADPCASNPCANGG-- 153

Query: 100 HDCLNIPGNYRCTCFDGFMLAHDGHNC-LDVDECLENNGGCQH--TCVNVMGSYECCCKE 156
             CL    +Y C C   F     G  C  DV+EC +  G C+H  TC N +GSY C C+ 
Sbjct: 154 -QCLPFEASYICHCPPSF----HGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208

Query: 157 GFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVA--CECRPGFELAKNQRDCI 214
                   HT  +     + C          C+  P G V   C C PGF   +N  + I
Sbjct: 209 -------THTGPNCERPYVPCSPSPCQNGGTCR--PTGDVTHECACLPGF-TGQNCEENI 258

Query: 215 LTC---NHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
             C   N  NGG   +C D  +   C C P++     G+ C E  D              
Sbjct: 259 DDCPGNNCKNGG---ACVDGVNTYNCRCPPEW----TGQYCTEDVD-------------- 297

Query: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC-KDIDECQTR 330
                 + +L+   C   NGG   TC +T  G +C C  G+T    G+ C ++ID+C   
Sbjct: 298 ------ECQLMPNAC--QNGG---TCHNTHGGYNCVCVNGWT----GEDCSENIDDC--A 340

Query: 331 NGGCDH--FCKNIVGSFDCGCKKG-FKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFAC 387
           +  C H   C + V SF C C  G   LL         + C+    CD + +N  G   C
Sbjct: 341 SAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVN--GKAIC 398

Query: 388 ACNRGYTLYGFTHCGDTNECSINNGGCQQV--CVNTVGSYECQCHPGY 433
            C  GYT  G     D +ECS+    C+    C+NT+GS+ECQC  GY
Sbjct: 399 TCPSGYT--GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY 444



 Score =  130 bits (328), Expect = 5e-30
 Identities = 114/419 (27%), Positives = 181/419 (43%), Gaps = 75/419 (17%)

Query: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCE-DIDECGNELNGGCVHD- 101
           +DVDEC+ G + C     C NT  S++C C  GY G   +CE D++EC   ++  C +D 
Sbjct: 411 QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGP--RCEIDVNEC---VSNPCQNDA 465

Query: 102 -CLNIPGNYRCTCFDGFMLAHDGHNC-LDVDECLENNGGCQHT--CVNVMGSYECCCKEG 157
            CL+  G ++C C  G+    +G +C ++ DEC   +  C H   C++ +  ++C C  G
Sbjct: 466 TCLDQIGEFQCICMPGY----EGVHCEVNTDECA--SSPCLHNGRCLDKINEFQCECPTG 519

Query: 158 FFLSDNQHTCIHRSEE--------GLSCMNKDHGCSHICKEAPRGSVA------CECRPG 203
           F      H C +  +E        G  C++  +  + +C E   G+        C+  P 
Sbjct: 520 F----TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPC 575

Query: 204 FELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVT 263
              +        TC    G   H C+   +  ECS  P       G +C +R++  L   
Sbjct: 576 HYGSCKDGVATFTCLCRPGYTGHHCETNIN--ECSSQP----CRHGGTCQDRDNAYLCFC 629

Query: 264 ESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR-TCKDTSTGVHCSCPVGFTLQLDGKTCK 322
              TT            + ++ CA  +  CD  TC D   G  C+C  G+T    G  C 
Sbjct: 630 LKGTTG-------PNCEINLDDCA--SSPCDSGTCLDKIDGYECACEPGYT----GSMCN 676

Query: 323 -DIDEC---QTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSC 378
            +IDEC      NGG    C++ +  F C C +G+    D     +V+EC+ +     +C
Sbjct: 677 INIDECAGNPCHNGGT---CEDGINGFTCRCPEGYH---DPTCLSEVNECNSNPCVHGAC 730

Query: 379 INHPGTFACACNRGYTLYGFTHCG-DTNECSIN---NGGCQQVCVNTVGSYECQCHPGY 433
            +    + C C+ G++    T+C  + NEC  N   NGG    C +    Y C C  G+
Sbjct: 731 RDSLNGYKCDCDPGWS---GTNCDINNNECESNPCVNGG---TCKDMTSGYVCTCREGF 783



 Score =  129 bits (323), Expect = 2e-29
 Identities = 147/555 (26%), Positives = 211/555 (38%), Gaps = 111/555 (20%)

Query: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCE-DIDECGNEL--NGGCVHD 101
            D++EC   L  C   A CQNT   Y+C C+ GY G  R CE DID+C      NGG   D
Sbjct: 869  DINECV--LSPCRHGASCQNTHGGYRCHCQAGYSG--RNCETDIDDCRPNPCHNGGSCTD 924

Query: 102  CLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGGCQHTCVNVMGSYECCCKEGFFL 160
             +N      C C  GF     G  C  D++EC  +       C + + SY C C  GF  
Sbjct: 925  GINTAF---CDCLPGFR----GTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGF-- 975

Query: 161  SDNQHTCIHRSEEGLSCMNKDHGCSH-------ICKEAPRGSVACECRPGFELAKNQRD- 212
                         G+ C N    C+         C +    S  C C PGF  +  Q D 
Sbjct: 976  ------------SGIHCENNTPDCTESSCFNGGTCVDGIN-SFTCLCPPGFTGSYCQHDV 1022

Query: 213  -------CIL--TCNHGNGGCQHSCDDTADGPECSCHPQYKMH-------TDGRSCLERE 256
                   C+   TC  G G  + +C     GP C    Q  +H        +G  C +  
Sbjct: 1023 NECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNC----QNLVHWCDSSPCKNGGKCWQTH 1078

Query: 257  DTVLEVTESNTTSV------VDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPV 310
                    S  T +      V  +   +R+ +       +GG    C D     HC C  
Sbjct: 1079 TQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGL---CVDAGNTHHCRCQA 1135

Query: 311  GFTLQLDGKTCKD-IDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECS 369
            G+T    G  C+D +DEC          C + +G + C C  G+  +      +++DEC 
Sbjct: 1136 GYT----GSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVN---CSEEIDEC- 1187

Query: 370  LDRTCDH--SCINHPGTFACACNRGYTLYGFTHCG-DTNECS------------INNGGC 414
            L   C +  +C++ P T+ C+C RG       HC  + ++C+             NNG  
Sbjct: 1188 LSHPCQNGGTCLDLPNTYKCSCPRGTQ---GVHCEINVDDCNPPVDPVSRSPKCFNNG-- 1242

Query: 415  QQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRC 474
               CV+ VG Y C C PG+     ++   +V   L      R + +C +      C  R 
Sbjct: 1243 --TCVDQVGGYSCTCPPGFV---GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA 1297

Query: 475  -HSGIHLSSDVTTIRTSVTFKLNEGKCSL--KNAELF----PEGLRPALPEKHSSVKESF 527
             H+G    S +   +       N G C++    A  F    P G   A  E  +    S 
Sbjct: 1298 GHTGRRCESVINGCKGKPC--KNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSL 1355

Query: 528  RYVN-LTCSSGKQVP 541
            R +N  TC SG + P
Sbjct: 1356 RCLNGGTCISGPRSP 1370



 Score =  120 bits (302), Expect = 5e-27
 Identities = 128/514 (24%), Positives = 177/514 (34%), Gaps = 142/514 (27%)

Query: 43  QEDVDECAQGLDDCHADALCQNTPTSYKCSCK---------------------------- 74
           ++DV+EC Q    C     C N   SY+C C+                            
Sbjct: 176 RQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRP 235

Query: 75  -----------PGYQGEGRQCEDIDEC--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAH 121
                      PG+ G+  + E+ID+C   N  NGG   D +N    Y C C   +    
Sbjct: 236 TGDVTHECACLPGFTGQNCE-ENIDDCPGNNCKNGGACVDGVN---TYNCRCPPEW---- 287

Query: 122 DGHNCL-DVDECLENNGGCQH--TCVNVMGSYECCCKEGFFLSDNQH--------TCIH- 169
            G  C  DVDEC      CQ+  TC N  G Y C C  G+   D            C H 
Sbjct: 288 TGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHG 347

Query: 170 ---------------RSEEGLSCMNKDHGCSHICKEAP-------RGSVACECRPGFELA 207
                              GL C   D   S+ C E          G   C C  G+   
Sbjct: 348 ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGP 407

Query: 208 KNQRDCILTCNHGNGGCQHS--CDDTADGPECSCHPQY---KMHTDGRSCL----EREDT 258
              +D +  C+ G   C+H+  C +T    EC C   Y   +   D   C+    + + T
Sbjct: 408 ACSQD-VDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDAT 466

Query: 259 VLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDG 318
            L+         + G + V   +  + CA +    +  C D      C CP GFT    G
Sbjct: 467 CLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFT----G 522

Query: 319 KTCK-DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS 377
             C+ D+DEC +        C +   ++ C C +G+   T      D+DEC  D     S
Sbjct: 523 HLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY---TGTHCEVDIDECDPDPCHYGS 579

Query: 378 CINHPGTFACACNRGYTLYGFTHC-GDTNECSI----NNGGCQQ---------------- 416
           C +   TF C C  GYT +   HC  + NECS     + G CQ                 
Sbjct: 580 CKDGVATFTCLCRPGYTGH---HCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGP 636

Query: 417 -----------------VCVNTVGSYECQCHPGY 433
                             C++ +  YEC C PGY
Sbjct: 637 NCEINLDDCASSPCDSGTCLDKIDGYECACEPGY 670



 Score =  120 bits (300), Expect = 8e-27
 Identities = 114/418 (27%), Positives = 164/418 (39%), Gaps = 98/418 (23%)

Query: 43  QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC-EDIDEC----GNELNGG 97
           +E++D+C    ++C     C +   +Y C C P + G+   C ED+DEC        NGG
Sbjct: 255 EENIDDCPG--NNCKNGGACVDGVNTYNCRCPPEWTGQ--YCTEDVDECQLMPNACQNGG 310

Query: 98  CVHDCLNIPGNYRCTCFDGFMLAHDGHNCLD-VDECLENNGGCQH--TCVNVMGSYECCC 154
             H   N  G Y C C +G+     G +C + +D+C   +  C H  TC + + S+ C C
Sbjct: 311 TCH---NTHGGYNCVCVNGWT----GEDCSENIDDCA--SAACFHGATCHDRVASFYCEC 361

Query: 155 KEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPR-------GSVACECRPGFELA 207
             G                GL C   D   S+ C E          G   C C  G+   
Sbjct: 362 PHG--------------RTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGP 407

Query: 208 KNQRDCILTCNHGNGGCQHS--CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTES 265
              +D +  C+ G   C+H+  C +T    EC C   Y     G  C       ++V E 
Sbjct: 408 ACSQD-VDECSLGANPCEHAGKCINTLGSFECQCLQGYT----GPRC------EIDVNE- 455

Query: 266 NTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCK-DI 324
                               C  N    D TC D      C C  G+    +G  C+ + 
Sbjct: 456 --------------------CVSNPCQNDATCLDQIGEFQCICMPGY----EGVHCEVNT 491

Query: 325 DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS--CINHP 382
           DEC +     +  C + +  F C C  GF   T      DVDEC+    C +   C++ P
Sbjct: 492 DECASSPCLHNGRCLDKINEFQCECPTGF---TGHLCQYDVDECA-STPCKNGAKCLDGP 547

Query: 383 GTFACACNRGYTLYGFTHCG-DTNECS---INNGGCQQVCVNTVGSYECQCHPGYKLH 436
            T+ C C  GYT    THC  D +EC     + G C+    + V ++ C C PGY  H
Sbjct: 548 NTYTCVCTEGYT---GTHCEVDIDECDPDPCHYGSCK----DGVATFTCLCRPGYTGH 598



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 103/406 (25%), Positives = 148/406 (36%), Gaps = 90/406 (22%)

Query: 47   DECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNE--LNGGCVHDCLN 104
            +EC    + C     C++  + Y C+C+ G+ G   Q  +I+EC +   LN G    C++
Sbjct: 755  NECES--NPCVNGGTCKDMTSGYVCTCREGFSGPNCQ-TNINECASNPCLNQG---TCID 808

Query: 105  IPGNYRCTCFDGFMLAHDGHNCLDV-----DECLENNGGCQHTCVNVMGSYECCCKEGF- 158
                Y+C C    +L + G  C  V          N G C+ +      S+ C C  G+ 
Sbjct: 809  DVAGYKCNC----LLPYTGATCEVVLAPCAPSPCRNGGECRQS--EDYESFSCVCPTGWQ 862

Query: 159  ---FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL 215
                  D     +     G SC N              G   C C+ G+   +N    I 
Sbjct: 863  GQTCEVDINECVLSPCRHGASCQN------------THGGYRCHCQAGYS-GRNCETDID 909

Query: 216  TCNHG---NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVD 272
             C      NGG   SC D  +   C C P ++    G  C E      ++ E        
Sbjct: 910  DCRPNPCHNGG---SCTDGINTAFCDCLPGFR----GTFCEE------DINE-------- 948

Query: 273  GDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNG 332
                         CA +       C D      C+CP GF+         D  E    NG
Sbjct: 949  -------------CASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNG 995

Query: 333  GCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH--SCINHPGTFACACN 390
            G    C + + SF C C  GF   T      DV+EC   + C H  +C +  G++ C C 
Sbjct: 996  GT---CVDGINSFTCLCPPGF---TGSYCQHDVNECD-SQPCLHGGTCQDGCGSYRCTCP 1048

Query: 391  RGYT---LYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGY 433
            +GYT        H  D++ C   NGG    C  T   Y C+C  G+
Sbjct: 1049 QGYTGPNCQNLVHWCDSSPC--KNGG---KCWQTHTQYRCECPSGW 1089



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 110/435 (25%), Positives = 166/435 (38%), Gaps = 107/435 (24%)

Query: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCE-DIDECGNEL-----NGG 97
            E++DEC      C     C + P +YKCSC  G QG    CE ++D+C   +     +  
Sbjct: 1182 EEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGTQGV--HCEINVDDCNPPVDPVSRSPK 1237

Query: 98   CVHD--CLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGGCQHT--CVNVMGSYEC 152
            C ++  C++  G Y CTC  GF+    G  C  DV+ECL N    + T  CV  +  + C
Sbjct: 1238 CFNNGTCVDQVGGYSCTCPPGFV----GERCEGDVNECLSNPCDARGTQNCVQRVNDFHC 1293

Query: 153  CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRD 212
             C+ G   +  +   +    +G  C  K+ G   +     RG + C+C  GFE A  + D
Sbjct: 1294 ECRAGH--TGRRCESVINGCKGKPC--KNGGTCAVASNTARGFI-CKCPAGFEGATCEND 1348

Query: 213  CILTCNH---GNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS 269
               TC      NGG   +C      P C C   +              T  E     ++ 
Sbjct: 1349 A-RTCGSLRCLNGG---TCISGPRSPTCLCLGPF--------------TGPECQFPASSP 1390

Query: 270  VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
             + G+              N G C+ T +  S    C CP  F    +G  C  +D    
Sbjct: 1391 CLGGNP-----------CYNQGTCEPTSE--SPFYRCLCPAKF----NGLLCHILDY--- 1430

Query: 330  RNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD---RTCDHSCINHPGTFA 386
                          SF  G  +       E++C ++ EC  D   + C   C NH    A
Sbjct: 1431 --------------SFGGGAGRDIPPPLIEEAC-ELPECQEDAGNKVCSLQCNNH----A 1471

Query: 387  CACNRGYTLYGFT----HCGDTNEC--SINNGGCQQVCVNTVG----SYEC-----QCHP 431
            C  + G     F     +C  + +C    ++G C   C N+ G     ++C     QC+P
Sbjct: 1472 CGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQC-NSAGCLFDGFDCQRAEGQCNP 1530

Query: 432  GY----KLHWNKKDC 442
             Y    K H++   C
Sbjct: 1531 LYDQYCKDHFSDGHC 1545



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 94/383 (24%), Positives = 128/383 (33%), Gaps = 122/383 (31%)

Query: 119 LAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCM 178
           LA  G  C    E   N G C+          E C   G F+         R ++   C+
Sbjct: 17  LAARGPRCSQPGETCLNGGKCE-----AANGTEACVCGGAFVGP-------RCQDPNPCL 64

Query: 179 N---KDHGCSHICKEAPRGSVACECRPGFE----LAKNQRDCILTCNHGNGGCQHSCD-D 230
           +   K+ G  H+         AC C  GF     L      C LT    NGG   +CD  
Sbjct: 65  STPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNAC-LTNPCRNGG---TCDLL 120

Query: 231 TADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVN- 289
           T    +C C P +     G+SC +                             + CA N 
Sbjct: 121 TLTEYKCRCPPGW----SGKSCQQ----------------------------ADPCASNP 148

Query: 290 --NGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCK-DIDECQTRNGGCDH--FCKNIVGS 344
             NGG    C        C CP  F     G TC+ D++EC  + G C H   C N VGS
Sbjct: 149 CANGG---QCLPFEASYICHCPPSF----HGPTCRQDVNECGQKPGLCRHGGTCHNEVGS 201

Query: 345 F---------------------------------------DCGCKKGFKLLTDEKSCQDV 365
           +                                       +C C  GF   T +   +++
Sbjct: 202 YRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGF---TGQNCEENI 258

Query: 366 DECSLDRTCDH--SCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQ--VCVNT 421
           D+C     C +  +C++   T+ C C   +T  G     D +EC +    CQ    C NT
Sbjct: 259 DDCP-GNNCKNGGACVDGVNTYNCRCPPEWT--GQYCTEDVDECQLMPNACQNGGTCHNT 315

Query: 422 VGSYECQCHPGYKLHWNKKDCVE 444
            G Y C C  G    W  +DC E
Sbjct: 316 HGGYNCVCVNG----WTGEDCSE 334



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 88/370 (23%), Positives = 131/370 (35%), Gaps = 77/370 (20%)

Query: 45   DVDECAQGLDDCHADALCQNTPT------SYKCSCKPGYQGEGRQCE-DIDEC-GNELNG 96
            +VD+C   +D       C N  T       Y C+C PG+ GE  +CE D++EC  N  + 
Sbjct: 1221 NVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE--RCEGDVNECLSNPCDA 1278

Query: 97   GCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLE----NNGGCQHTCVNVMGSYEC 152
                +C+    ++ C C  G    H G  C  V    +     NGG      N    + C
Sbjct: 1279 RGTQNCVQRVNDFHCECRAG----HTGRRCESVINGCKGKPCKNGGTCAVASNTARGFIC 1334

Query: 153  CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHI-------CKEAPRGSVACECRPGFE 205
             C  GF              EG +C N    C  +       C   PR S  C C   F 
Sbjct: 1335 KCPAGF--------------EGATCENDARTCGSLRCLNGGTCISGPR-SPTCLCLGPFT 1379

Query: 206  LAKNQRDCILTCNHGNGGC--QHSCDDTADGP--ECSCHPQYKMHTDGRSCLEREDTVLE 261
              + Q      C  GN  C  Q +C+ T++ P   C C  ++    +G  C      +L+
Sbjct: 1380 GPECQFPASSPCLGGN-PCYNQGTCEPTSESPFYRCLCPAKF----NGLLC-----HILD 1429

Query: 262  VTESNTTSVVDGDKRVKRRLLMETCAV-------NNGGCDRTCKDTSTGVH-CSCPVGFT 313
             +           + +   L+ E C +        N  C   C + + G     C + F 
Sbjct: 1430 YSFGG-----GAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNF- 1483

Query: 314  LQLDGKTCKDIDEC--QTRNGGCDHFCKN---IVGSFDCGCKKGFKLLTDEKSCQDVDEC 368
                 K C    +C     +G CD  C +   +   FDC   +G      ++ C+D    
Sbjct: 1484 -NDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFS- 1541

Query: 369  SLDRTCDHSC 378
              D  CD  C
Sbjct: 1542 --DGHCDQGC 1549


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  138 bits (347), Expect = 3e-32
 Identities = 142/494 (28%), Positives = 194/494 (39%), Gaps = 123/494 (24%)

Query: 33  PPG-RGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG------------ 79
           PPG +GR+   + DVDEC  G + C     C NTP S++C C  GY G            
Sbjct: 147 PPGYQGRSC--RSDVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAP 203

Query: 80  -------------------------EGRQCE-DIDECGNE--LNGGCVHDCLNIPGNYRC 111
                                    EG+ CE ++D+C     LNGG   D +N    Y C
Sbjct: 204 SPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN---TYNC 260

Query: 112 TCFDGFMLAHDGHNCL-DVDECLENNGGCQH--TCVNVMGSYECCCKEGF---FLSDN-- 163
            C   +     G  C  DVDEC      C +  TC N +G + C C  G+     S N  
Sbjct: 261 QCPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNID 316

Query: 164 ---QHTCIH----------------RSEEGLSCMNKDHGCSHICKE-------APRGSVA 197
                 C H                  + GL C   D   S+ C E          G   
Sbjct: 317 DCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAI 376

Query: 198 CECRPGFELAKNQRDCILTCNHGNGGCQH--SCDDTADGPECSCHPQY---KMHTDGRSC 252
           C C PGF      +D +  C+ G   C+H   C +T     C C   Y   +  TD   C
Sbjct: 377 CTCPPGFTGGACDQD-VDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNEC 435

Query: 253 L----EREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVN---NGGCDRTCKDTSTGVH 305
           L      + T L+     T   + G       + ++ C  +   NGG    CKD   G  
Sbjct: 436 LSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGG---VCKDRVNGFS 492

Query: 306 CSCPVGFTLQLDGKTCK-DIDECQT---RNGGCDHFCKNIVGSFDCGCKKGFK-LLTDEK 360
           C+CP GF+    G TC+ D+DEC +   RNG     C +    ++C C +GF+  L D  
Sbjct: 493 CTCPSGFS----GSTCQLDVDECASTPCRNGA---KCVDQPDGYECRCAEGFEGTLCD-- 543

Query: 361 SCQDVDECSLDRTCDHS-CINHPGTFACACNRGYTLYGFTHC-GDTNECSINNGGCQQVC 418
             ++VD+CS D  C H  C++   +F+CAC  GYT    T C    +EC          C
Sbjct: 544 --RNVDDCSPD-PCHHGRCVDGIASFSCACAPGYT---GTRCESQVDECRSQPCRHGGKC 597

Query: 419 VNTVGSYECQCHPG 432
           ++ V  Y C+C  G
Sbjct: 598 LDLVDKYLCRCPSG 611



 Score =  120 bits (302), Expect = 5e-27
 Identities = 134/480 (27%), Positives = 175/480 (36%), Gaps = 113/480 (23%)

Query: 22  LPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPT-SYKCSCKPGYQGE 80
           LP LLLLAG      G AA P  D   CA G         C   P+    C C PG+ GE
Sbjct: 27  LPLLLLLAGP-----GAAAPPCLDGSPCANG-------GRCTQLPSREAACLCPPGWVGE 74

Query: 81  GRQCEDIDECGNELNGGCVHD---------------------------CLNIP------- 106
             Q ED    G     G                               CL+ P       
Sbjct: 75  RCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARC 134

Query: 107 -----GNYRCTCFDGFMLAHDGHNC-LDVDECLENNGGCQH--TCVNVMGSYECCCKEGF 158
                G + C+C  G+     G +C  DVDEC      C+H  TC+N  GS+ C C  G+
Sbjct: 135 SVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGE-PCRHGGTCLNTPGSFRCQCPAGY 189

Query: 159 F--LSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFE---LAKNQRDC 213
              L +N           + C          C+++   +  C C PGFE      N  DC
Sbjct: 190 TGPLCEN---------PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC 240

Query: 214 ILTCNHG--NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERED-------------T 258
                H   NGG   +C D  +   C C P++     G+ C E  D             T
Sbjct: 241 ---PGHRCLNGG---TCVDGVNTYNCQCPPEW----TGQFCTEDVDECQLQPNACHNGGT 290

Query: 259 VLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDG 318
                  ++   V+G         ++ CA        TC D     +C+CP+G T    G
Sbjct: 291 CFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKT----G 346

Query: 319 KTCKDIDECQTRNGGCDHFCKN--IVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCD 375
             C   D C +     D  C    + G   C C  GF   T     QDVDECS+    C+
Sbjct: 347 LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF---TGGACDQDVDECSIGANPCE 403

Query: 376 H--SCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGY 433
           H   C+N  G+F C C RGYT  G     D NEC       Q  C++ +G + C C  G+
Sbjct: 404 HLGRCVNTQGSFLCQCGRGYT--GPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGF 461



 Score =  115 bits (289), Expect = 2e-25
 Identities = 122/433 (28%), Positives = 160/433 (36%), Gaps = 82/433 (18%)

Query: 33  PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCE-DIDECG 91
           PPG    A  Q DVDEC+ G + C     C NT  S+ C C  GY G   +CE D++EC 
Sbjct: 380 PPGFTGGACDQ-DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGP--RCETDVNEC- 435

Query: 92  NELNGGCVHD--CLNIPGNYRCTCFDGFMLAHDGHNC-LDVDECLEN---NGGCQHTCVN 145
             L+G C +   CL+  G + C C  GF     G  C +D+DEC  +   NGG    C +
Sbjct: 436 --LSGPCRNQATCLDRIGQFTCICMAGF----TGTYCEVDIDECQSSPCVNGG---VCKD 486

Query: 146 VMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFE 205
            +  + C C  GF    +  TC    +E   C +        C + P G   C C  GFE
Sbjct: 487 RVNGFSCTCPSGF----SGSTCQLDVDE---CASTPCRNGAKCVDQPDG-YECRCAEGFE 538

Query: 206 ---LAKNQRDCIL-TCNHGNGGCQHSCDDTADGPECSCHPQY-----KMHTD-------- 248
                +N  DC    C+HG       C D      C+C P Y     +   D        
Sbjct: 539 GTLCDRNVDDCSPDPCHHGR------CVDGIASFSCACAPGYTGTRCESQVDECRSQPCR 592

Query: 249 -GRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR------TCKDTS 301
            G  CL+  D  L    S TT V               C VN   C         C+D  
Sbjct: 593 HGGKCLDLVDKYLCRCPSGTTGV--------------NCEVNIDDCASNPCTFGVCRDGI 638

Query: 302 TGVHCSCPVGFTLQLDGKTCK-DIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEK 360
               C C  GFT    G  C  +I+EC +   G    C +    F C C  G    +   
Sbjct: 639 NRYDCVCQPGFT----GPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPG----SLPP 690

Query: 361 SCQDVDECSLDRTCDHS-CINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCV 419
            C           C H  C + PG F C C  G++    +     + C          C 
Sbjct: 691 LCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCS 750

Query: 420 NTVGSYECQCHPG 432
           +    + C C PG
Sbjct: 751 SDGMGFHCTCPPG 763



 Score =  110 bits (276), Expect = 5e-24
 Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 114/518 (22%)

Query: 33   PPG-RGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYK-CSCKPGYQGEGRQCEDIDEC 90
            PPG +GR     E +  C    + C     C++ P     CSC  G+QG   Q +D+DEC
Sbjct: 761  PPGVQGRQC---ELLSPCTP--NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ-QDVDEC 814

Query: 91   GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC-LDVDECLEN---NGGCQHTCVNV 146
                  G    C N+ G++ CTC  G+     G +C  D+++C  N   NGG   +C + 
Sbjct: 815  AGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNPCLNGG---SCQDG 867

Query: 147  MGSYECCCKEGFF---LSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPR---------- 193
            +GS+ C C  GF     + +   C+       +C   DH  S  C   P           
Sbjct: 868  VGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTC--TDHVASFTCTCPPGYGGFHCEQDL 925

Query: 194  ------------------GSVACECRPGFELAKNQ--------RDCIL--TCNHGNGGCQ 225
                               S +C CRPG+  A  Q        R C+    C+  + G +
Sbjct: 926  PDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFR 985

Query: 226  HSCDDTADGPECS----------CHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDK 275
             +C ++  GP+C           C    +    G  CL        + +  +    +   
Sbjct: 986  CTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAA 1045

Query: 276  RVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC-KDIDECQTRNGGC 334
            ++  R L + C    GG    C D  +  +C CP G T    G  C +++D C  +   C
Sbjct: 1046 QIGVR-LEQLCQA--GG---QCVDEDSSHYCVCPEGRT----GSHCEQEVDPCLAQ--PC 1093

Query: 335  DH--FCKNIVGSFDCGCKKGFKLLTDEKSCQ-DVDECSLDRTCDH--SCINHPGTFACAC 389
             H   C+  +G + C C  G+    +  +C+ DVDEC+  + C H  SCI+    + C+C
Sbjct: 1094 QHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECA-SQPCQHGGSCIDLVARYLCSC 1148

Query: 390  NRGYTL-----YGFTHCG-----DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNK 439
              G TL          CG     D+    ++NG     CV+ VG + C C PGY     +
Sbjct: 1149 PPG-TLGVLCEINEDDCGPGPPLDSGPRCLHNG----TCVDLVGGFRCTCPPGYTGLRCE 1203

Query: 440  KDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSG 477
             D  E +     +   R  L     GGG  C   CH+G
Sbjct: 1204 ADINECRSGACHAAHTRDCLQ--DPGGGFRCL--CHAG 1237



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 116/461 (25%), Positives = 163/461 (35%), Gaps = 138/461 (29%)

Query: 43   QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNE--LNGGCVH 100
            Q+DVDECA G   C    +C N   S+ C+C  GY G     +DI++C     LNGG   
Sbjct: 808  QQDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD-QDINDCDPNPCLNGGSCQ 865

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNCL-DVDECLENNGG--------------------- 138
            D +   G++ C+C  GF     G  C  DVDECL N  G                     
Sbjct: 866  DGV---GSFSCSCLPGFA----GPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGG 918

Query: 139  --CQH--------------TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDH 182
              C+               TCV+ + S+ C C+ G+       T  H   E   C+++  
Sbjct: 919  FHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY-------TGAHCQHEADPCLSRP- 970

Query: 183  GCSH--ICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCH 240
             C H  +C  A  G   C C   F   + Q   +  C+     CQ+       G  C C 
Sbjct: 971  -CLHGGVCSAAHPG-FRCTCLESFTGPQCQT-LVDWCSRQP--CQNGGRCVQTGAYCLCP 1025

Query: 241  PQYKMHT-DGRSCLEREDTV-----LE---------VTESNTTSVVDGDKRVKRRLLMET 285
            P +     D RS   RE        LE         V E ++   V  + R       E 
Sbjct: 1026 PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV 1085

Query: 286  CAVNNGGCDR--TCKDTSTGVHCSCPVGFTLQLDGKTCKD-IDECQTR---NGG------ 333
                   C    TC+    G  C C  G+    +G  C+D +DEC ++   +GG      
Sbjct: 1086 DPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQPCQHGGSCIDLV 1141

Query: 334  ----------------------------------CDH--FCKNIVGSFDCGCKKGFKLLT 357
                                              C H   C ++VG F C C  G+  L 
Sbjct: 1142 ARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR 1201

Query: 358  DEKSCQDVDEC---SLDRTCDHSCINHP-GTFACACNRGYT 394
             E    D++EC   +        C+  P G F C C+ G++
Sbjct: 1202 CE---ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS 1239



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 112/487 (22%), Positives = 164/487 (33%), Gaps = 132/487 (27%)

Query: 43   QEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVH-- 100
            +++VD C      C     C+     Y C C PGY G+  + +D+DEC ++    C H  
Sbjct: 1082 EQEVDPCLA--QPCQHGGTCRGYMGGYMCECLPGYNGDNCE-DDVDECASQ---PCQHGG 1135

Query: 101  DCLNIPGNYRCTCFDGFMLAHDGHNC-LDVDEC-----LENNGGCQH--TCVNVMGSYEC 152
             C+++   Y C+C  G +    G  C ++ D+C     L++   C H  TCV+++G + C
Sbjct: 1136 SCIDLVARYLCSCPPGTL----GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRC 1191

Query: 153  CCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHI--CKEAPRGSVACECRPGFELAKNQ 210
             C  G+       T +    +   C +     +H   C + P G   C C  GF   + Q
Sbjct: 1192 TCPPGY-------TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244

Query: 211  RDCILT------CNHGNGGCQHS------------------------------------- 227
               +L+      C HG G C+ S                                     
Sbjct: 1245 T--VLSPCESQPCQHG-GQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVG 1301

Query: 228  --CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS---VVDGDKRVKRRLL 282
              C  T  GP C+C P       G SC     +    + ++  +   +  G  R      
Sbjct: 1302 VPCQQTPRGPRCACPP----GLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAP 1357

Query: 283  METCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIV 342
               CA         C    TG  C  P       +   C     CQ + G  D  C    
Sbjct: 1358 FFRCA---------CAQGWTGPRCEAPAAAPEVSEEPRCPRA-ACQAKRG--DQRCDREC 1405

Query: 343  GSFDCGCKKGFKLLT---DEKSCQDVDECSL--DRTCDHSCIN----------HPGTFAC 387
             S  CG   G   L+     + C+ +    L  +  CD +C +          H G    
Sbjct: 1406 NSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRER 1465

Query: 388  ACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCV-EVK 446
             CN  Y  Y   H  D        G C Q C     + EC         W+  DC  EV 
Sbjct: 1466 TCNPVYEKYCADHFAD--------GRCDQGC----NTEEC--------GWDGLDCASEVP 1505

Query: 447  GLLPTSV 453
             LL   V
Sbjct: 1506 ALLARGV 1512


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,328,535
Number of Sequences: 37866
Number of extensions: 2682099
Number of successful extensions: 15310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 6208
Number of HSP's gapped (non-prelim): 3360
length of query: 999
length of database: 18,247,518
effective HSP length: 112
effective length of query: 887
effective length of database: 14,006,526
effective search space: 12423788562
effective search space used: 12423788562
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.