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Search of human proteins with 18677729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18677729 relaxin/insulin-like family peptide receptor 2
[Homo sapiens]
(754 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 1535 0.0
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 796 0.0
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 164 2e-40
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 155 2e-37
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 153 6e-37
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 152 8e-37
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 151 2e-36
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 133 5e-31
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 131 2e-30
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 127 4e-29
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 127 4e-29
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 127 5e-29
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 127 5e-29
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 123 5e-28
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 123 5e-28
gi|198041768 synleurin [Homo sapiens] 122 2e-27
gi|153251229 chondroadherin precursor [Homo sapiens] 115 1e-25
gi|225579152 insulin-like growth factor binding protein, acid la... 109 1e-23
gi|4826772 insulin-like growth factor binding protein, acid labi... 109 1e-23
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 107 5e-23
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 107 5e-23
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 103 8e-22
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 102 1e-21
gi|51317373 netrin-G1 ligand [Homo sapiens] 102 2e-21
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 100 4e-21
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 100 4e-21
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 98 3e-20
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 96 9e-20
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 95 2e-19
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 95 3e-19
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 1535 bits (3974), Expect = 0.0
Identities = 754/754 (100%), Positives = 754/754 (100%)
Query: 1 MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLP 60
MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLP
Sbjct: 1 MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLP 60
Query: 61 RAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKET 120
RAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKET
Sbjct: 61 RAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKET 120
Query: 121 ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKA 180
ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKA
Sbjct: 121 ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKA 180
Query: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM
Sbjct: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
Query: 241 VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT 300
VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT
Sbjct: 241 VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT 300
Query: 301 FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL
Sbjct: 301 FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Query: 361 ERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRI 420
ERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRI
Sbjct: 361 ERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRI 420
Query: 421 FVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRG 480
FVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRG
Sbjct: 421 FVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRG 480
Query: 481 QYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV 540
QYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV
Sbjct: 481 QYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV 540
Query: 541 ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLL 600
ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLL
Sbjct: 541 ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLL 600
Query: 601 AFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKIL 660
AFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKIL
Sbjct: 601 AFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKIL 660
Query: 661 SLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKK 720
SLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKK
Sbjct: 661 SLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKK 720
Query: 721 SLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS 754
SLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
Sbjct: 721 SLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS 754
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 796 bits (2055), Expect = 0.0
Identities = 394/716 (55%), Positives = 520/716 (72%), Gaps = 11/716 (1%)
Query: 24 FIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDT 83
F +LI K F+ G + C GYFPCGN+TKCLP+ HC+G DDCGN ADE+NCGD
Sbjct: 8 FYILIFGKYFSHGGGQDV--KCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDN 65
Query: 84 SGWATIFGTVHGNANSV-------ALTQECFLKQYPQCCDCKETELECVNGDLKSVPMIS 136
+GW+ F + + A T EC + P C C+ EL+C +L++VP +S
Sbjct: 66 NGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVS 125
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
+NVT +SL+ N I LP F Y L+K++LQ+N I IS AF GL +L LYL+HN
Sbjct: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
Query: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP-KQMCAQ 255
IT L+PG+F+DLH+L WLI++DN ++RIS F GLNSL L ++NN L LP K +C
Sbjct: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
Query: 256 MPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSN 315
MP+L+W+DLEGN I L N TF+SC +LTVL + +N+I + E TF+ L+ L ELDL SN
Sbjct: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
Query: 316 TITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQP 375
I L P +FKDLK L +LNLS NP+ + NQF+ L +L+SL LE IEI NI RMF+P
Sbjct: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
Query: 376 MKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLF 435
+ NLSHIYFK F+YC YAPHVR C P TDGISS E+LLA+ I R+FVWV++ +TCFGN+F
Sbjct: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425
Query: 436 VIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQC 495
VI MR +I++EN +AMSI LCCADCLMG+YLF +G FD+K+RG+Y K+A LWMES C
Sbjct: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485
Query: 496 RLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVI 555
+L+G LA+LSTEVSVLLLT+LTLEK++ IV+PF +RPGK +T +LI IW+ GF++A I
Sbjct: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFI 545
Query: 556 PFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCS 615
P NK++F N+YG NGVCFPL+ + TE IG++ YS+ IFLG+NL AF+IIVFSY +MF S
Sbjct: 546 PLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYS 605
Query: 616 IQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWI 675
+ ++A+ TE+RN +E+ +A RFFFIVF+DA+CWIP+FVVK LSL +VEIP T+TSW+
Sbjct: 606 VHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWV 665
Query: 676 VIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKH-QRKSIFKIKKKSLSTSIVWIE 730
VIF LP+NSALNPILYTLTT FK+ + + + + QRKS+ +K+ + S +W+E
Sbjct: 666 VIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVE 721
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 164 bits (416), Expect = 2e-40
Identities = 168/681 (24%), Positives = 287/681 (42%), Gaps = 112/681 (16%)
Query: 126 NGDLKSVPM--ISNNVTL--LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAF 181
+ L VP+ +SN TL L+L NKI S+PD F + L + L +N IR +S+ F
Sbjct: 162 DNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCF 221
Query: 182 FGLCNLQILYLNHN-----------------------CITTLRPGIFKDLHQLTWLILDD 218
GL NL+ L LN+N I+ + G F L + L D
Sbjct: 222 DGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYD 281
Query: 219 NPITRISQRLFTGLNSLFFL-----SMVNNY------------------LEALPKQMCAQ 255
NP++ + F L+ L L SMV + + ++P +C +
Sbjct: 282 NPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQE 341
Query: 256 MPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSN 315
L +DL N I+ L + F C +L + L RNQI + E TF L +L LDLS N
Sbjct: 342 QKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
Query: 316 TITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQP 375
I E+ F L + L++S N L L QL+ + +++ + + F
Sbjct: 400 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLK-EALAAKDFVN 458
Query: 376 MKNLSHIYFKN---FRYC-SYA---------------------------------PHVRI 398
+++LS Y F C SYA H +I
Sbjct: 459 LRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI 518
Query: 399 ---CMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHA-MSI 454
C P T E LL + ++R+ VW I + F NL VI + +F + + + I
Sbjct: 519 IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVI-LTTFASCTSLPSSKLFI 577
Query: 455 KILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLT 514
++ ++ MG+Y + D G++ ++ + W C++ GFLA+ S+E ++ LL
Sbjct: 578 GLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLM 637
Query: 515 YLTLEKFLVIVFPFSNIRPGK-RQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVC 573
T+E+ L N + +Q V + ++ + P +++ Y + +C
Sbjct: 638 LATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHR----GEYSASPLC 693
Query: 574 FPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGRE 633
P T + S G+++ + L +N LAFL++ Y ++C+++K L +
Sbjct: 694 LPF---PTGETPSLGFTVTLVL-LNSLAFLLMAVIYTKLYCNLEKEDLSENS-------Q 742
Query: 634 VAVANRFFFIVFSDAICWIPVFVVKILSLF-RVEIPDTMTSWIVIFFLPVNSALNPILYT 692
++ +++F++ I + PV L + I + + + F P+ + LNP+LY
Sbjct: 743 SSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYV 802
Query: 693 LTTNFFKDKLKQLLHKHQRKS 713
FK+ K L + +KS
Sbjct: 803 FFNPKFKEDWKLLKRRVTKKS 823
Score = 100 bits (248), Expect = 7e-21
Identities = 77/284 (27%), Positives = 128/284 (45%), Gaps = 3/284 (1%)
Query: 115 CDCK-ETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNC 172
C C + ++C L +VP +S L + N I LP+ F + L+++ L N
Sbjct: 33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGND 92
Query: 173 IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGL 232
+ I KA GL L++L L +N + T+ + L L L LD N IT + + F GL
Sbjct: 93 LSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGL 152
Query: 233 NSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQ 292
L L + +N L +P + +P L + L N+I + + F + SL VL L N+
Sbjct: 153 VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 212
Query: 293 IGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESL 352
I + + F L NL LDL+ N + E P K L L++L SN + + F+
Sbjct: 213 IRSLSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGN 271
Query: 353 KQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHV 396
L+++ L + + F + +L + + P++
Sbjct: 272 PLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNL 315
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 155 bits (391), Expect = 2e-37
Identities = 153/609 (25%), Positives = 279/609 (45%), Gaps = 62/609 (10%)
Query: 127 GDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQH-NCIRHISRKAFFGLC 185
GDL+ + + N+V + + VF KL +I ++ N + +I+ +AF L
Sbjct: 70 GDLEKIEISQNDV---------LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
Query: 186 NLQILYLNHNCITTLRPGIFKDLHQLTWLILD--DN-PITRISQRLFTGLNSLFFLSMVN 242
NLQ L +++ I L P + K +H L ++LD DN I I + F GL+ + +N
Sbjct: 121 NLQYLLISNTGIKHL-PDVHK-IHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLN 178
Query: 243 -NYLEALPKQMCA----QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
N ++ + CA Q+ +LN D N ++ L N F +L + R +I +P
Sbjct: 179 KNGIQEIHN--CAFNGTQLDELNLSD--NNNLEELPNDVFHGASGPVILDISRTRIHSLP 234
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQ-KLNLSSNPLMYLH-KNQFESLKQL 355
L+NL +L S + P L K + L++ L S+ + + + Q L +
Sbjct: 235 SY---GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPI 291
Query: 356 QSLDLERIEIPNI-------------NTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPL 402
+ + R E+ + N + ++++ F ++ C+ V C P
Sbjct: 292 CNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEF-DYDLCNEVVDVT-CSPK 349
Query: 403 TDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADC 462
D + ED++ NILR+ +W I+ + GN+ V+ + + + + T + L AD
Sbjct: 350 PDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADL 409
Query: 463 LMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFL 522
+G+YL + DI + QY YA+ W C GF + ++E+SV LT +TLE++
Sbjct: 410 CIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWH 469
Query: 523 VIVFPFS-NIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQ 580
I + + R + +++ W+ F A+ P FG + Y K +C P+ D
Sbjct: 470 TITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPI-----FGISSYMKVSICLPMDIDS 524
Query: 581 TEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRF 640
S+ Y + + L +N+LAF++I YI ++ +++ + ++ + +A R
Sbjct: 525 PL---SQLYVMSL-LVLNVLAFVVICGCYIHIYLTVRNPNIVSS------SSDTRIAKRM 574
Query: 641 FFIVFSDAICWIPVFVVKILSLFRVE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFK 699
++F+D +C P+ I + +V I + +++ F P+NS NP LY + T F+
Sbjct: 575 AMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFR 634
Query: 700 DKLKQLLHK 708
LL K
Sbjct: 635 RDFFILLSK 643
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 153 bits (386), Expect = 6e-37
Identities = 161/655 (24%), Positives = 285/655 (43%), Gaps = 65/655 (9%)
Query: 112 PQCCDC-KETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFL-Q 169
P+ C+C + L C P + +T LSL + +P + F ++ KI + Q
Sbjct: 31 PEPCNCVPDGALRC--------PGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQ 82
Query: 170 HNCIRHISRKAFFGLCNL-QILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQ-- 226
+ + I AF L NL +IL N + + PG F +L +L +L + + I +
Sbjct: 83 IDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVT 142
Query: 227 RLFTGLNSLFFLSMVNN-YLEALPKQMCAQMPQLN-WVDLEGNRIKYLTNSTFLSCDSLT 284
++F+ S F L + +N ++ +P M + + L GN + + + F + +LT
Sbjct: 143 KVFSS-ESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAF-NGTTLT 200
Query: 285 VLFLPRN-QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLL--------QKL- 334
L L N + + F LD+SS + L + + ++ L +KL
Sbjct: 201 SLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLP 260
Query: 335 ------NLSSNPLMY------------LHKNQFESLKQLQSLDLERIEIPNINTRMFQPM 376
NL L Y +N S+ + S E N ++ M
Sbjct: 261 SRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSM 320
Query: 377 KNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFV 436
S + ++ Y P C P D + ED++ + LR+ +W+I + GN+ V
Sbjct: 321 LAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTV 380
Query: 437 IGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCR 496
+ + + + T + L AD MG+YL + D + +GQY +A+ W C
Sbjct: 381 LFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCS 440
Query: 497 LMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFS-NIRPGKRQTSVILICIWMAGFLIAVI 555
GF + ++E+SV LT +TLE++ I + + + R +I++ W+ LIA++
Sbjct: 441 TAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAML 500
Query: 556 PFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCS 615
P + Y K +CFP+ E S+ Y L I + +N++AF II YI ++ +
Sbjct: 501 PLVGV----SNYMKVSICFPM---DVETTLSQVYILTILI-LNVVAFFIICACYIKIYFA 552
Query: 616 IQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVE-IPDTMTSW 674
++ L T ++ +A + ++F+D C P+ I + F+V I T +
Sbjct: 553 VRNPELMAT------NKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKV 606
Query: 675 IVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHK----HQRKSIFKIKKKSLSTS 725
+++ F P+NS NP LY + T F+ LL K +R +++ K S TS
Sbjct: 607 LLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTS 661
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 152 bits (385), Expect = 8e-37
Identities = 163/663 (24%), Positives = 268/663 (40%), Gaps = 118/663 (17%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
++L NKIH +PD F + L + L +N I + +K F GL +L+ L LN+N +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF- 249
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLE--------------- 246
P + L L L N I I ++ F G SL + +N ++
Sbjct: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 247 --------------------------------ALPKQMCAQMPQLNWVDLEGNRIKYLTN 274
+LP+ +C Q+P L +DL N ++ L +
Sbjct: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
Query: 275 STFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKL 334
F C L + L N+I + TF L +L L+L+ N I + P+ F L L KL
Sbjct: 370 --FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKL 427
Query: 335 NLSSN-----PLMYLHKNQFESL---KQLQSL-------DLERIEIP------------- 366
+LSSN P+ LH L LQSL +L+ IE+P
Sbjct: 428 DLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCEN 487
Query: 367 --------------------NINTRMFQPMKNLS-HIYFKNFRYCSYAPHVRICMPLTDG 405
+ MFQ + +F A H C P
Sbjct: 488 AYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGP 547
Query: 406 ISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMG 465
E LL ++RI VW IA + N V + + I ++ + L G
Sbjct: 548 FKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTG 607
Query: 466 VYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIV 525
V + D G + ++ W V C ++GFL++ ++E SV LLT LE+ +
Sbjct: 608 VSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVK 667
Query: 526 F--PFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTED 583
+ F P +IL+C +A +A +P G+ YG + +C PL + +
Sbjct: 668 YSAKFETKAPFSSLKVIILLCALLA-LTMAAVPLLG----GSKYGASPLCLPLPFGEP-- 720
Query: 584 IGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFI 643
+ GY + + L +N L FL++ +Y ++C++ K L+ + +C ++ +
Sbjct: 721 -STMGYMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLE--NIWDC-----SMVKHIALL 771
Query: 644 VFSDAICWIPVFVVKILSLFRVE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKL 702
+F++ I PV + SL + I + +I++ +P+ + LNP+LY L FK+ L
Sbjct: 772 LFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Query: 703 KQL 705
L
Sbjct: 832 VSL 834
Score = 89.4 bits (220), Expect = 1e-17
Identities = 75/278 (26%), Positives = 127/278 (45%), Gaps = 7/278 (2%)
Query: 108 LKQYPQCCDCKET-----ELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYT 161
L+ P C C+ ++C + L +P +S + L L N I L
Sbjct: 31 LRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR 90
Query: 162 KLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPI 221
L+++ L N + +I + AF GL +L++L L +N + + ++L L L LD N I
Sbjct: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Query: 222 TRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCD 281
+ + F+GL+SL L + +N L +P Q + L + L N+I ++ + F +
Sbjct: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLS 210
Query: 282 SLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPL 341
SL VL L N+I + +K F L +L LDL+ N + E P + L L++L SN +
Sbjct: 211 SLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNI 269
Query: 342 MYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 379
+ + F L ++ I + FQ + L
Sbjct: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPEL 307
Score = 83.2 bits (204), Expect = 8e-16
Identities = 62/195 (31%), Positives = 93/195 (47%), Gaps = 1/195 (0%)
Query: 190 LYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP 249
L L+ N I+ L P L L L L N +T I + FTGL SL L + NN L +P
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 250 KQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGE 309
+ + L + L+ N I Y+ S F SL L+L N + +P + F SL L
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 310 LDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNIN 369
+ L+ N I + + F +L L L+L +N + L K F+ L L++LDL +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 370 TRMFQPMKNLSHIYF 384
T + + + NL + F
Sbjct: 251 TAI-RTLSNLKELGF 264
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/182 (30%), Positives = 85/182 (46%), Gaps = 15/182 (8%)
Query: 241 VNNYLEALPKQMCAQMPQLNWVD---LEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
+NN + LP + P L +++ L GN + Y+ F SL VL L NQ+ VP
Sbjct: 75 MNNISQLLPNPL----PSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
+ +L++L L L +N I+ + P F L L+ L L N L + F SL LQ+
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFE--DLLAN 415
+ L +I +I F + +L ++ N R S + C DG+ S E DL N
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG---KKCF---DGLHSLETLDLNYN 244
Query: 416 NI 417
N+
Sbjct: 245 NL 246
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 151 bits (381), Expect = 2e-36
Identities = 141/585 (24%), Positives = 278/585 (47%), Gaps = 41/585 (7%)
Query: 136 SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHN 195
SN V L +++K+ +P + +L+ + + +R I + AF G +L+ + ++ N
Sbjct: 26 SNRVFLC--QESKVTEIPSDLPRNAIELRFVLTK---LRVIQKGAFSGFGDLEKIEISQN 80
Query: 196 -CITTLRPGIFKDLHQLTWLILDD-NPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMC 253
+ + +F +L +L + ++ N + I+ F L +L +L + N ++ LP
Sbjct: 81 DVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHK 140
Query: 254 AQMPQLNWVDLEGN-RIKYLTNSTF--LSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGEL 310
Q +D++ N I + ++F LS +S+ +L+L +N I + F+ + L EL
Sbjct: 141 IHSLQKVLLDIQDNINIHTIERNSFVGLSFESV-ILWLNKNGIQEIHNCAFNGTQ-LDEL 198
Query: 311 DLS-SNTITELSPHLFKDLK---LLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIP 366
+LS +N + EL +F +L +L+ N + + + + + Q + +R +
Sbjct: 199 NLSDNNNLEELPNDVFHGASGPVILSELHPICNKSIL--RQEVDYMTQARG---QRSSLA 253
Query: 367 NINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIA 426
N + ++++ F ++ C+ V C P D + ED++ NILR+ +W I+
Sbjct: 254 EDNESSYSRGFDMTYTEF-DYDLCNEVVDVT-CSPKPDAFNPCEDIMGYNILRVLIWFIS 311
Query: 427 FITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYA 486
+ GN+ V+ + + + + T + L AD +G+YL + DI + QY YA
Sbjct: 312 ILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYA 371
Query: 487 LLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFS-NIRPGKRQTSVILICI 545
+ W C GF + ++E+SV LT +TLE++ I + + R + +++
Sbjct: 372 IDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMG 431
Query: 546 WMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLI 604
W+ F A+ P FG + Y K +C P+ D S+ Y + + L +N+LAF++
Sbjct: 432 WIFAFAAALFPI-----FGISSYMKVSICLPMDIDSPL---SQLYVMSL-LVLNVLAFVV 482
Query: 605 IVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFR 664
I YI ++ +++ + ++ + +A R ++F+D +C P+ I + +
Sbjct: 483 ICGCYIHIYLTVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLK 536
Query: 665 VE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHK 708
V I + +++ F P+NS NP LY + T F+ LL K
Sbjct: 537 VPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSK 581
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 133 bits (335), Expect = 5e-31
Identities = 92/276 (33%), Positives = 142/276 (51%), Gaps = 8/276 (2%)
Query: 112 PQCCDCKETE-LECVNGDLKSVPMISN-----NVTLLSLKKNKIHSLPDKVFIKYTKLKK 165
P+ CDC+ + L C N L+ VP S+ +V SL N I ++ F + +L++
Sbjct: 28 PERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRR 87
Query: 166 IFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRIS 225
+ LQ+N IR + K F L L+ LYL +N + L PG L +L L + N I+R+S
Sbjct: 88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLS 147
Query: 226 QRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTV 285
+ F GL SL L + N L ALP + A + L ++ LE NRI++L + F L
Sbjct: 148 RGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRF 207
Query: 286 LFLPRNQI--GFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMY 343
L L N++ TF+ L++L L LS+N + L P +F+ L L L+L N L +
Sbjct: 208 LNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTH 267
Query: 344 LHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 379
L F L+ L+ L LE + + T + +P+ +L
Sbjct: 268 LAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSL 303
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/205 (32%), Positives = 95/205 (46%), Gaps = 2/205 (0%)
Query: 192 LNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQ 251
L N IT + F L QL L L N I + + F L+ L L + NN L+AL
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 252 MCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELD 311
A + +L + GN I L+ +F +SL L L N +G +P+ F+ L NL L
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 312 LSSNTITELSPHLFKDLKLLQKLNLSSNPLM--YLHKNQFESLKQLQSLDLERIEIPNIN 369
L SN I L + F L L+ LNLS+N L H F L+ L SL L + ++
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
Query: 370 TRMFQPMKNLSHIYFKNFRYCSYAP 394
R+FQ + L + + + AP
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAP 270
Score = 83.2 bits (204), Expect = 8e-16
Identities = 65/203 (32%), Positives = 94/203 (46%), Gaps = 8/203 (3%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N + +LPD VF L + L+ N IR + + AF L L+ L L+ N L+
Sbjct: 160 LRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSAN---ELQ 216
Query: 202 PGI-----FKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
P + F L L+ LIL N + + R+F L L LS+ N L L + +
Sbjct: 217 PSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGL 276
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
L + LEGNR+ L + SL L L N++ + TF L L EL L +N
Sbjct: 277 EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNA 336
Query: 317 ITELSPHLFKDLKLLQKLNLSSN 339
++ LS +F L +L+L N
Sbjct: 337 LSALSGDIFAASPALYRLDLDGN 359
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/130 (31%), Positives = 67/130 (51%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
+++ L L N + L ++F +L + L+ N + H++ +AF+GL L+ L L N +
Sbjct: 230 SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
+ L + + LH L L L N ++ + F L L LS+ NN L AL + A P
Sbjct: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
Query: 258 QLNWVDLEGN 267
L +DL+GN
Sbjct: 350 ALYRLDLDGN 359
Score = 58.2 bits (139), Expect = 3e-08
Identities = 45/152 (29%), Positives = 68/152 (44%), Gaps = 1/152 (0%)
Query: 238 LSMVNNYLEALPKQMCAQMPQ-LNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFV 296
L N L +PK P + L GN I +T F L L L NQI +
Sbjct: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
Query: 297 PEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQ 356
KTF L L EL L +N + L+P L+ L+ L + N + L + FE L+ L
Sbjct: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
Query: 357 SLDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
L L+ + + +F P+ NL +++ ++ R
Sbjct: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNR 190
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 131 bits (330), Expect = 2e-30
Identities = 154/692 (22%), Positives = 285/692 (41%), Gaps = 123/692 (17%)
Query: 115 CDC-KETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNC- 172
C+C +E + D++ +P + + L L + + ++P F + +I++ +
Sbjct: 29 CECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVT 88
Query: 173 IRHISRKAFFGLCNLQILYL-NHNCITTLRPGIFKDLHQLTWL----------------- 214
++ + +F+ L + + + N +T + P K+L L +L
Sbjct: 89 LQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVY 148
Query: 215 ------ILD--DNP-ITRISQRLFTGL-NSLFFLSMVNNYLEALPKQMCAQMPQLNWVDL 264
IL+ DNP +T I F GL N L + NN ++ Q N L
Sbjct: 149 STDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSV------QGYAFNGTKL 202
Query: 265 EG---NRIKYLT------------NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGE 309
+ N+ KYLT + L +V LP + + E + L +
Sbjct: 203 DAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKK 262
Query: 310 LDLSSN----TITELS--PHL--FKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD-- 359
L LS + T +LS H FK+ K ++ + S + +++ +SL+Q +S++
Sbjct: 263 LPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILES----LMCNESSMQSLRQRKSVNAL 318
Query: 360 ---LERIEIPNINTRM--------FQPMKNLSHIY----------------FKN------ 386
L + N+ + FQ N +H Y KN
Sbjct: 319 NSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETL 378
Query: 387 --------FRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIG 438
+ C + + +C P +D + ED++ LRI VW ++ + GN+FV+
Sbjct: 379 QAFDSHYDYTICGDSEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLL 437
Query: 439 MRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLM 498
+ + + L AD MG+YL + D+ +Y +A+ W C
Sbjct: 438 ILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTA 497
Query: 499 GFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGK-RQTSVILICIWMAGFLIAVIPF 557
GF + ++E+SV LT +TLE++ I F R + R I++ W+ FL+A++P
Sbjct: 498 GFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPL 557
Query: 558 WNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQ 617
+ Y K +C P+ TE + Y + + L +N++AF+I+ Y+ ++ +++
Sbjct: 558 VGI----SSYAKVSICLPM---DTETPLALAYIVFV-LTLNIVAFVIVCCCYVKIYITVR 609
Query: 618 KTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWI-V 676
N ++ +A R ++F+D IC P+ + ++ + S I +
Sbjct: 610 NPQY------NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILL 663
Query: 677 IFFLPVNSALNPILYTLTTNFFKDKLKQLLHK 708
+ F P+NS NP LY + T F+ + LL K
Sbjct: 664 VLFYPLNSCANPFLYAIFTKAFQRDVFILLSK 695
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 127 bits (319), Expect = 4e-29
Identities = 86/250 (34%), Positives = 127/250 (50%)
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
+N+ L L N + +PD F L K+ L N + HIS + F L NLQ+L L N
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
+T + G F L L L L N I +S LF ++L L + NN++ LP + Q+
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
PQLN + L GN +K L+ F +L L+L N I +P+ FS+L+ L L LS N
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334
Query: 317 ITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPM 376
I+ +SP F L L++L+L +N L L N F L LQ++ L+ + + +F +
Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394
Query: 377 KNLSHIYFKN 386
L I +N
Sbjct: 395 NGLMAIQLQN 404
Score = 120 bits (301), Expect = 5e-27
Identities = 85/276 (30%), Positives = 137/276 (49%), Gaps = 6/276 (2%)
Query: 111 YPQCCDCKETELECVNGDLKSVPMISNN----VTLLSLKKNKIHSLPDKVFIKYTKLKKI 166
+ QC + KE +L L+ +P + + +T L+L KN + + +VF L+ +
Sbjct: 151 FSQCSNLKELQLH--GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 208
Query: 167 FLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQ 226
L N + I F GL NLQ L L N I L PG+F + H L L L +N I+++
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268
Query: 227 RLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVL 286
+F L L L++ N L+ L + MP L + L N I L ++ F + L VL
Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 328
Query: 287 FLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHK 346
L RNQI F+ F+ L L EL L +N + +L ++F+ L LQ ++L +N L L
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388
Query: 347 NQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
N F ++ L ++ L+ ++ N+ +F + L +
Sbjct: 389 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 424
Score = 109 bits (272), Expect = 1e-23
Identities = 81/274 (29%), Positives = 134/274 (48%), Gaps = 2/274 (0%)
Query: 112 PQCCDC-KETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQ 169
P C C + +++EC + +VP + N L + I L + F+ + L + ++
Sbjct: 32 PSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIE 91
Query: 170 HNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLF 229
N + I+ AF L +L+ L L +N + L G+F+ L L L+L N + +I F
Sbjct: 92 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHF 151
Query: 230 TGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLP 289
+ ++L L + N+LE +P + L ++L N + +++ F +L VL L
Sbjct: 152 SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY 211
Query: 290 RNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQF 349
N++ +P TF L NL EL L N I LSP LF + LQ+L LS+N + L + F
Sbjct: 212 ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIF 271
Query: 350 ESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIY 383
L QL L L + ++ +F PM NL ++
Sbjct: 272 MQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 305
Score = 104 bits (259), Expect = 3e-22
Identities = 68/236 (28%), Positives = 115/236 (48%)
Query: 186 NLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYL 245
N L + + IT L F ++ L L ++ N ++RI+ F L SL +LS+ NN L
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 246 EALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLK 305
+ LP + + L + L N++ + + F C +L L L N + ++P+ F L
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179
Query: 306 NLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEI 365
L +L+L N++T +SP +F+ L LQ L L N L + F+ L LQ L L++ +I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 366 PNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIF 421
++ +F NL +Y N P + + +P + ++ F + L L IF
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 295
Score = 89.0 bits (219), Expect = 1e-17
Identities = 58/180 (32%), Positives = 92/180 (51%)
Query: 136 SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHN 195
++N+ L L N I LP +F++ +L ++ L N ++ +S F + NL+ L+L N
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 196 CITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQ 255
I++L +F +L QL LIL N I+ IS F GL L LS+ N L+ L +
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 369
Query: 256 MPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSN 315
+ L + L+ NR++ L + F + + L + L NQ+ +P F L L EL L N
Sbjct: 370 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/79 (35%), Positives = 38/79 (48%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
LSL N + L VF L+ I LQ+N +R + F + L + L +N + L
Sbjct: 352 LSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Query: 202 PGIFKDLHQLTWLILDDNP 220
GIF L +L L L DNP
Sbjct: 412 LGIFDHLGKLCELRLYDNP 430
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 127 bits (319), Expect = 4e-29
Identities = 86/250 (34%), Positives = 127/250 (50%)
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
+N+ L L N + +PD F L K+ L N + HIS + F L NLQ+L L N
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208
Query: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
+T + G F L L L L N I +S LF ++L L + NN++ LP + Q+
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
PQLN + L GN +K L+ F +L L+L N I +P+ FS+L+ L L LS N
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
Query: 317 ITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPM 376
I+ +SP F L L++L+L +N L L N F L LQ++ L+ + + +F +
Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
Query: 377 KNLSHIYFKN 386
L I +N
Sbjct: 389 NGLMAIQLQN 398
Score = 120 bits (301), Expect = 5e-27
Identities = 85/276 (30%), Positives = 137/276 (49%), Gaps = 6/276 (2%)
Query: 111 YPQCCDCKETELECVNGDLKSVPMISNN----VTLLSLKKNKIHSLPDKVFIKYTKLKKI 166
+ QC + KE +L L+ +P + + +T L+L KN + + +VF L+ +
Sbjct: 145 FSQCSNLKELQLH--GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVL 202
Query: 167 FLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQ 226
L N + I F GL NLQ L L N I L PG+F + H L L L +N I+++
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
Query: 227 RLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVL 286
+F L L L++ N L+ L + MP L + L N I L ++ F + L VL
Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322
Query: 287 FLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHK 346
L RNQI F+ F+ L L EL L +N + +L ++F+ L LQ ++L +N L L
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382
Query: 347 NQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
N F ++ L ++ L+ ++ N+ +F + L +
Sbjct: 383 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 418
Score = 109 bits (272), Expect = 1e-23
Identities = 81/274 (29%), Positives = 134/274 (48%), Gaps = 2/274 (0%)
Query: 112 PQCCDC-KETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQ 169
P C C + +++EC + +VP + N L + I L + F+ + L + ++
Sbjct: 26 PSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIE 85
Query: 170 HNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLF 229
N + I+ AF L +L+ L L +N + L G+F+ L L L+L N + +I F
Sbjct: 86 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHF 145
Query: 230 TGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLP 289
+ ++L L + N+LE +P + L ++L N + +++ F +L VL L
Sbjct: 146 SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY 205
Query: 290 RNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQF 349
N++ +P TF L NL EL L N I LSP LF + LQ+L LS+N + L + F
Sbjct: 206 ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIF 265
Query: 350 ESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIY 383
L QL L L + ++ +F PM NL ++
Sbjct: 266 MQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 299
Score = 104 bits (259), Expect = 3e-22
Identities = 68/236 (28%), Positives = 115/236 (48%)
Query: 186 NLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYL 245
N L + + IT L F ++ L L ++ N ++RI+ F L SL +LS+ NN L
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 246 EALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLK 305
+ LP + + L + L N++ + + F C +L L L N + ++P+ F L
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
Query: 306 NLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEI 365
L +L+L N++T +SP +F+ L LQ L L N L + F+ L LQ L L++ +I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 366 PNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIF 421
++ +F NL +Y N P + + +P + ++ F + L L IF
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 289
Score = 89.0 bits (219), Expect = 1e-17
Identities = 58/180 (32%), Positives = 92/180 (51%)
Query: 136 SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHN 195
++N+ L L N I LP +F++ +L ++ L N ++ +S F + NL+ L+L N
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Query: 196 CITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQ 255
I++L +F +L QL LIL N I+ IS F GL L LS+ N L+ L +
Sbjct: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 363
Query: 256 MPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSN 315
+ L + L+ NR++ L + F + + L + L NQ+ +P F L L EL L N
Sbjct: 364 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/79 (35%), Positives = 38/79 (48%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
LSL N + L VF L+ I LQ+N +R + F + L + L +N + L
Sbjct: 346 LSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Query: 202 PGIFKDLHQLTWLILDDNP 220
GIF L +L L L DNP
Sbjct: 406 LGIFDHLGKLCELRLYDNP 424
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 127 bits (318), Expect = 5e-29
Identities = 158/675 (23%), Positives = 275/675 (40%), Gaps = 135/675 (20%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
++L N+I +PD F T L + L +N I+H+ +F GL NL+ L LN+N +
Sbjct: 139 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF- 197
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTG------------------------------ 231
P + L +L L +N I I ++ F G
Sbjct: 198 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 257
Query: 232 -----------------LNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTN 274
SL L++ + LP MC Q+P+L ++L N+I+ L +
Sbjct: 258 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
Query: 275 ----------------------STFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDL 312
TF SL L L N I + + FS+L +L +LDL
Sbjct: 318 LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDL 377
Query: 313 SSNTITELSP---------HLFKDLKLLQ--------KLNLSSNPLMY------LHKNQF 349
+ N +T L L +L L Q KL + P Y + + F
Sbjct: 378 TDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFF 437
Query: 350 ESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA-----PHVRI-CMPLT 403
++ Q ++ DL + + + + + Y ++ PH + C P
Sbjct: 438 KASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTP 497
Query: 404 DGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKI----LCC 459
E L + +R+ VW I ++ N V+ + A +K +
Sbjct: 498 GPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLPPVKFVVGAIAG 554
Query: 460 ADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLE 519
A+ L G+ + D GQ+ +Y W + CR GFLA+L +E SVLLLT ++
Sbjct: 555 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ 614
Query: 520 KFLVIVFPFSNIRPGKRQTSV------ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVC 573
+ + S +R + S+ +L C+ +AG L A +P + YG + +C
Sbjct: 615 CSVSV----SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAALPLASV----GEYGASPLC 665
Query: 574 FPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGRE 633
P Y + G+++ + + +N FL++ +YI ++C + + + V +C
Sbjct: 666 LP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPRGDFEA--VWDC---- 717
Query: 634 VAVANRFFFIVFSDAICWIPVFVV---KILSLFRVEIPDTMTSWIVIFFLPVNSALNPIL 690
A+ +++F+D + + PV + +L LF V P+ + S +++ LP+ + LNP+L
Sbjct: 718 -AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLL 774
Query: 691 YTLTTNFFKDKLKQL 705
Y L F+D L++L
Sbjct: 775 YLLFNPHFRDDLRRL 789
Score = 93.6 bits (231), Expect = 6e-19
Identities = 74/251 (29%), Positives = 119/251 (47%), Gaps = 1/251 (0%)
Query: 129 LKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQ 188
L V +S ++ L N + L +F L+++ L N + HI +AF GL +L+
Sbjct: 6 LTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 65
Query: 189 ILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEAL 248
IL L +N + + +L L L LD N I+ + +R F GL+SL L + +N L +
Sbjct: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
Query: 249 PKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLG 308
P + +P L + L NRI ++ + F + SL VL L N+I + +F L NL
Sbjct: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 185
Query: 309 ELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNI 368
LDL+ N + E P + L LQ+L +N + + + F LQ++ I +
Sbjct: 186 TLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV 244
Query: 369 NTRMFQPMKNL 379
FQ + L
Sbjct: 245 GRSAFQYLPKL 255
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/103 (36%), Positives = 50/103 (48%), Gaps = 5/103 (4%)
Query: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
+L L N+I LP + KL++I LQHN I I F L +LQ L L+ N I ++
Sbjct: 304 VLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 361
Query: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNN 243
P F LH L L L DN +T + GL L L + N
Sbjct: 362 HPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 43.5 bits (101), Expect = 7e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 311 DLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINT 370
DLS N +TEL P LF L+ L++L LS N L ++ F L L+ L L+ ++ I
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 371 RMFQPMKNLSHI 382
+ +L +
Sbjct: 80 EALWELPSLQSL 91
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 127 bits (318), Expect = 5e-29
Identities = 158/675 (23%), Positives = 275/675 (40%), Gaps = 135/675 (20%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
++L N+I +PD F T L + L +N I+H+ +F GL NL+ L LN+N +
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF- 249
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTG------------------------------ 231
P + L +L L +N I I ++ F G
Sbjct: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
Query: 232 -----------------LNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTN 274
SL L++ + LP MC Q+P+L ++L N+I+ L +
Sbjct: 310 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 369
Query: 275 ----------------------STFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDL 312
TF SL L L N I + + FS+L +L +LDL
Sbjct: 370 LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDL 429
Query: 313 SSNTITELSP---------HLFKDLKLLQ--------KLNLSSNPLMY------LHKNQF 349
+ N +T L L +L L Q KL + P Y + + F
Sbjct: 430 TDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFF 489
Query: 350 ESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA-----PHVRI-CMPLT 403
++ Q ++ DL + + + + + Y ++ PH + C P
Sbjct: 490 KASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTP 549
Query: 404 DGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKI----LCC 459
E L + +R+ VW I ++ N V+ + A +K +
Sbjct: 550 GPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLPPVKFVVGAIAG 606
Query: 460 ADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLE 519
A+ L G+ + D GQ+ +Y W + CR GFLA+L +E SVLLLT ++
Sbjct: 607 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ 666
Query: 520 KFLVIVFPFSNIRPGKRQTSV------ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVC 573
+ + S +R + S+ +L C+ +AG L A +P + YG + +C
Sbjct: 667 CSVSV----SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAALPLASV----GEYGASPLC 717
Query: 574 FPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGRE 633
P Y + G+++ + + +N FL++ +YI ++C + + + V +C
Sbjct: 718 LP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPRGDFEA--VWDC---- 769
Query: 634 VAVANRFFFIVFSDAICWIPVFVV---KILSLFRVEIPDTMTSWIVIFFLPVNSALNPIL 690
A+ +++F+D + + PV + +L LF V P+ + S +++ LP+ + LNP+L
Sbjct: 770 -AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLL 826
Query: 691 YTLTTNFFKDKLKQL 705
Y L F+D L++L
Sbjct: 827 YLLFNPHFRDDLRRL 841
Score = 101 bits (251), Expect = 3e-21
Identities = 80/264 (30%), Positives = 123/264 (46%), Gaps = 7/264 (2%)
Query: 116 DCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRH 175
DC E L V GDL + L L N + L +F L+++ L N + H
Sbjct: 51 DCSELGLSAVPGDLDPL------TAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH 104
Query: 176 ISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSL 235
I +AF GL +L+IL L +N + + +L L L LD N I+ + +R F GL+SL
Sbjct: 105 IPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSL 164
Query: 236 FFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGF 295
L + +N L +P + +P L + L NRI ++ + F + SL VL L N+I
Sbjct: 165 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH 224
Query: 296 VPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQL 355
+ +F L NL LDL+ N + E P + L LQ+L +N + + + F L
Sbjct: 225 LGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLL 283
Query: 356 QSLDLERIEIPNINTRMFQPMKNL 379
Q++ I + FQ + L
Sbjct: 284 QTIHFYDNPIQFVGRSAFQYLPKL 307
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/103 (36%), Positives = 50/103 (48%), Gaps = 5/103 (4%)
Query: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
+L L N+I LP + KL++I LQHN I I F L +LQ L L+ N I ++
Sbjct: 356 VLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413
Query: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNN 243
P F LH L L L DN +T + GL L L + N
Sbjct: 414 HPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/73 (34%), Positives = 38/73 (52%)
Query: 310 LDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNIN 369
LDLS N +TEL P LF L+ L++L LS N L ++ F L L+ L L+ ++ I
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 370 TRMFQPMKNLSHI 382
+ +L +
Sbjct: 131 AEALWELPSLQSL 143
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 123 bits (309), Expect = 5e-28
Identities = 80/241 (33%), Positives = 126/241 (52%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L+ N++ +LP ++F T LK + L N + + + F L +LQ L L++N ++ L
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
G+F L L L LD N I+ + ++F+ L L L + N + LP + A + L +
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L+ N ++ L F L L L NQ+ V E TF+ L NL L LS N IT L
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSH 381
+F+DL+ L KL L SN L LH F++L +L+ L L + ++ + +F NL +
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
Query: 382 I 382
+
Sbjct: 390 L 390
Score = 112 bits (279), Expect = 2e-24
Identities = 75/219 (34%), Positives = 115/219 (52%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L+L +N + LP+++F T L+ + L +N + + + F L +LQ L+L+ N I+ L
Sbjct: 174 LNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P +F L L L L N IT + +F L +L FLS+ N L LP + A P L
Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVG 293
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L N+++ + TF +L L L N I +P F L+ L +L L SN +T L
Sbjct: 294 LSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALH 353
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
P LF++L L+ L+LS N L L + F++ L +L L
Sbjct: 354 PALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL 392
Score = 89.0 bits (219), Expect = 1e-17
Identities = 77/272 (28%), Positives = 125/272 (45%), Gaps = 25/272 (9%)
Query: 112 PQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHN 171
P CDC E+ C + +L +VP+ +P YTK I
Sbjct: 23 PMGCDCFVQEVFCSDEELATVPL----------------DIPP-----YTK--NIIFVET 59
Query: 172 CIRHISRKAFFGLCNL-QILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
+ +AF NL ++++LN + RP F L +L L + + +S +F+
Sbjct: 60 SFTTLETRAFGSNPNLTKVVFLNTQ-LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPR 290
L SL L++ N LEALP+ + + L + L+GN+++ L F L L L +
Sbjct: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 291 NQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFE 350
N + +PE+ F L +L L LS+N ++ L +F L LQ+L L SN + L F
Sbjct: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
Query: 351 SLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
L L+ L L+R I ++ +F + NL+ +
Sbjct: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFL 270
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/130 (36%), Positives = 67/130 (51%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+T LSL+ N + LP +F L + L HN + ++ F L NL+ L L++N I
Sbjct: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
T L GIF+DL +L L L N +T + LF L+ L LS+ N L LP+ +
Sbjct: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNY 385
Query: 258 QLNWVDLEGN 267
L + L GN
Sbjct: 386 NLFNLALHGN 395
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/183 (25%), Positives = 77/183 (42%)
Query: 214 LILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
+I + T + R F +L + +N L +P+L +++ G+ L+
Sbjct: 54 IIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLS 113
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
+ F + SL L L N + +PE F L L L L N + L LF+ L L+
Sbjct: 114 TNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKT 173
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA 393
LNL+ N L L + F L LQ+L L + + +F + +L ++ +
Sbjct: 174 LNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233
Query: 394 PHV 396
P V
Sbjct: 234 PQV 236
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/84 (34%), Positives = 42/84 (50%)
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
+N+ L L N I LP +F +L K++L N + + F L L++L L+ N
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 197 ITTLRPGIFKDLHQLTWLILDDNP 220
+TTL GIF + L L L NP
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGNP 396
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 123 bits (309), Expect = 5e-28
Identities = 151/606 (24%), Positives = 258/606 (42%), Gaps = 68/606 (11%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L N I ++P+K F+ L+ I N I+ + R AF L L L LN
Sbjct: 123 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 182
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P + K L L L I + + L L L + +N +E LP Q +L
Sbjct: 183 PDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ--KLEE 239
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L+ NRI + TF SL L L N I + + FS+L +L +LDL+ N +T L
Sbjct: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
Query: 322 P---------HLFKDLKLLQ--------KLNLSSNPLMY------LHKNQFESLKQLQSL 358
L +L L Q KL + P Y + + F++ Q ++
Sbjct: 300 LAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAE 359
Query: 359 DLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA-----PHVRI-CMPLTDGISSFEDL 412
DL + + + + + Y ++ PH + C P E L
Sbjct: 360 DLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYL 419
Query: 413 LANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKI----LCCADCLMGVYL 468
+ +R+ VW I ++ N V+ + A +K + A+ L G+
Sbjct: 420 FESWGIRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLPPVKFVVGAIAGANTLTGISC 476
Query: 469 FFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPF 528
+ D GQ+ +Y W + CR GFLA+L +E SVLLLT ++ + +
Sbjct: 477 GLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV---- 532
Query: 529 SNIRPGKRQTSV------ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTE 582
S +R + S+ +L C+ +AG L A +P + YG + +C P Y
Sbjct: 533 SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAALPLASV----GEYGASPLCLP-YAPPEG 586
Query: 583 DIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFF 642
+ G+++ + + +N FL++ +YI ++C + + + V +C A+ +
Sbjct: 587 QPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPRGDFEA--VWDC-----AMVRHVAW 638
Query: 643 IVFSDAICWIPVFVV---KILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFK 699
++F+D + + PV + +L LF V P+ + S +++ LP+ + LNP+LY L F+
Sbjct: 639 LIFADGLLYCPVAFLSFASMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFR 696
Query: 700 DKLKQL 705
D L++L
Sbjct: 697 DDLRRL 702
Score = 77.4 bits (189), Expect = 5e-14
Identities = 64/203 (31%), Positives = 96/203 (47%), Gaps = 4/203 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L NK+ P + +L+++ +N I+ I KAF G LQ ++ N I +
Sbjct: 100 LDLNYNKLQEFPVAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 158
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
F+ L +L L L+ + L G SL L++ + LP MC Q+P+L
Sbjct: 159 RSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 217
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
++L N+I+ L + C L + L N+I + TFS L +L LDLS N I +
Sbjct: 218 LELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 275
Query: 322 PHLFKDLKLLQKLNLSSNPLMYL 344
P F L L KL+L+ N L L
Sbjct: 276 PEAFSTLHSLVKLDLTDNQLTTL 298
Score = 63.5 bits (153), Expect = 7e-10
Identities = 45/169 (26%), Positives = 75/169 (44%), Gaps = 25/169 (14%)
Query: 192 LNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQ 251
L+ N +T L+PG+F L L L L N ++ I + F+GL SL L + NN L +P +
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
Query: 252 MCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELD 311
++P L +DL N+++ +L L EL
Sbjct: 90 ALWELPSLQSLDLNYNKLQEF-------------------------PVAIRTLGRLQELG 124
Query: 312 LSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
+N I + F LLQ ++ NP+ ++ ++ F+ L +L +L L
Sbjct: 125 FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 173
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/103 (36%), Positives = 50/103 (48%), Gaps = 5/103 (4%)
Query: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
+L L N+I LP + KL++I LQHN I I F L +LQ L L+ N I ++
Sbjct: 217 VLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 274
Query: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNN 243
P F LH L L L DN +T + GL L L + N
Sbjct: 275 HPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
Score = 43.5 bits (101), Expect = 7e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 311 DLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINT 370
DLS N +TEL P LF L+ L++L LS N L ++ F L L+ L L+ ++ I
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
Query: 371 RMFQPMKNLSHI 382
+ +L +
Sbjct: 89 EALWELPSLQSL 100
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 122 bits (305), Expect = 2e-27
Identities = 85/273 (31%), Positives = 132/273 (48%), Gaps = 3/273 (1%)
Query: 114 CCDCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNC 172
C C ++ C N L S+P + L L N I + + L ++L ++
Sbjct: 36 CQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSN 95
Query: 173 IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGL 232
I ++ KAF L +L L+LN+N I L PGIFK L L L L N ++ + + +F L
Sbjct: 96 ILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDL 155
Query: 233 NSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQ 292
S+ +L++ N L L M L +DL N I ++ S F ++L L+L N
Sbjct: 156 VSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNN 215
Query: 293 IGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESL 352
+ VP F LK+L L LS N I + P FK L L+ L L ++ + + ++ F +
Sbjct: 216 LTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI 275
Query: 353 KQLQSLDLERIEIPNINTRMFQPMKNLSHIYFK 385
L+ L L ++ N+N+ F +KNL IY K
Sbjct: 276 NNLKHLILSHNDLENLNSDTFSLLKNL--IYLK 306
Score = 94.4 bits (233), Expect = 4e-19
Identities = 71/242 (29%), Positives = 114/242 (47%), Gaps = 1/242 (0%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N I L +F L+ ++LQ+N + + R F L ++Q L L N +T L
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
G F + L L L +N I RIS+ F L +L L + +N L +P + L
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L N I+ + F +L L L ++I V FS + NL L LS N + L+
Sbjct: 233 LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLN 292
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESL-KQLQSLDLERIEIPNINTRMFQPMKNLS 380
F LK L L L N ++ + + FE++ L+ L+L + ++ R+ +P+ +L
Sbjct: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
Query: 381 HI 382
H+
Sbjct: 353 HL 354
Score = 90.1 bits (222), Expect = 7e-18
Identities = 67/219 (30%), Positives = 107/219 (48%), Gaps = 1/219 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+ L L+ N++ +P VF ++ + LQ N + + F G+ L+IL L++N I
Sbjct: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
+ F+ L L L L N +T++ F L SL LS+ +N +EA+ +
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA 252
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
L ++ L+ +RI+ +T F ++L L L N + + TFS LKNL L L N I
Sbjct: 253 NLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRI 312
Query: 318 TELSPHLFKDL-KLLQKLNLSSNPLMYLHKNQFESLKQL 355
+ F+++ L+ LNLS N L LH + L L
Sbjct: 313 ISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSL 351
Score = 60.5 bits (145), Expect = 6e-09
Identities = 39/123 (31%), Positives = 60/123 (48%)
Query: 264 LEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPH 323
L GN I Y+ S SL L+L + I +V K F L++L L L++N I L P
Sbjct: 67 LTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPG 126
Query: 324 LFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIY 383
+FK L L+ L L N + ++ + F L +Q L+L+R + + + F M L +
Sbjct: 127 IFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILD 186
Query: 384 FKN 386
N
Sbjct: 187 LSN 189
Score = 37.0 bits (84), Expect = 0.068
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 1/85 (1%)
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGL-CNLQILYLNHN 195
NN+ L L N + +L F L + L N I I F + +L+IL L+ N
Sbjct: 276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFN 335
Query: 196 CITTLRPGIFKDLHQLTWLILDDNP 220
+T L P + K L L L + NP
Sbjct: 336 NLTALHPRVLKPLSSLIHLQANSNP 360
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 115 bits (289), Expect = 1e-25
Identities = 81/280 (28%), Positives = 124/280 (44%), Gaps = 27/280 (9%)
Query: 112 PQCCDCKET--ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQ 169
PQ C C + C L+ +P +S LL+L++N L F L + LQ
Sbjct: 24 PQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQ 83
Query: 170 HNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLF 229
H IR ++ AF GL L LYL+HN I LR G F DL +LT+L LD N +T + + L
Sbjct: 84 HCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLL 143
Query: 230 TGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLP 289
+ L +LF L + NN + L L W+ L N + L ++L +
Sbjct: 144 SPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVD 203
Query: 290 RNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQF 349
RNQ+ P S L +++++L LS NPL + N F
Sbjct: 204 RNQLSSYPSAALSKL------------------------RVVEELKLSHNPLKSIPDNAF 239
Query: 350 ESL-KQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
+S + L++L L+ + + F + L H++ +N R
Sbjct: 240 QSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNR 279
Score = 49.3 bits (116), Expect = 1e-05
Identities = 39/155 (25%), Positives = 62/155 (40%)
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
L++ N L MP L + L+ +I+ + F L L+L N I +
Sbjct: 56 LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
F L L L L N +TEL L L L L L++N + L F+ K L+
Sbjct: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSY 392
L L + ++ ++NL+ + + SY
Sbjct: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSY 210
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/160 (23%), Positives = 58/160 (36%), Gaps = 49/160 (30%)
Query: 139 VTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCIT 198
+T L L NK+ LP + L + L +N IR + AF G +L+ LYL+ N ++
Sbjct: 125 LTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALS 184
Query: 199 TLRPGIFKDLHQLT---------------------------------------------- 212
+L+PG D+ L
Sbjct: 185 SLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGR 244
Query: 213 ---WLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP 249
L LD+ + + S F G+ +L + + NN L LP
Sbjct: 245 YLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP 284
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 109 bits (272), Expect = 1e-23
Identities = 75/243 (30%), Positives = 115/243 (47%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+ L L++N++ SL F L + L +N + + F GL +L L L N +
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
L F+ L L L+L N + + LF+GL L L + N L A+ + Q+P
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
+L + L+ N I + FL +L L L N++ + E TF L L L LS N I
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
Query: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMK 377
L P FKDL L++L L N + L + FE L QL+ L L+ ++ + F +
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Query: 378 NLS 380
N++
Sbjct: 401 NVA 403
Score = 109 bits (272), Expect = 1e-23
Identities = 85/301 (28%), Positives = 136/301 (45%), Gaps = 48/301 (15%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFF------------------- 182
L L +N + ++ VF++ +L+K++L N I ++ AF
Sbjct: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320
Query: 183 -----GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSL-- 235
GL L++L L+HN I +LRP FKDLH L L L N I ++++R F GL L
Sbjct: 321 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 380
Query: 236 --------------FFLSMVN--------NYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
FL + N N L LP+Q+ + +L+ + LEG+ + +
Sbjct: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
TF L LFL N + + E++ L L ELDL+SN +T L LF+ L L+
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA 393
L LS N L L + L++ LD+ + + + P+ L ++ +N ++
Sbjct: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT 560
Query: 394 P 394
P
Sbjct: 561 P 561
Score = 100 bits (249), Expect = 5e-21
Identities = 75/271 (27%), Positives = 116/271 (42%), Gaps = 24/271 (8%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N++ L +F +L+++ L N +R I F L LQ LYL+ N I +
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
PG F L L WL L N + + + F GL L L + +N + +L + + L
Sbjct: 297 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 356
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFV------------------------P 297
+ L NRI+ L +F L VL L NQ+ V P
Sbjct: 357 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
E+ F L L L L + + + PH F L L++L L N L+ + + L +L
Sbjct: 417 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE 476
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
LDL ++ ++ R+FQ + L ++ R
Sbjct: 477 LDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 507
Score = 100 bits (248), Expect = 7e-21
Identities = 80/268 (29%), Positives = 122/268 (45%), Gaps = 1/268 (0%)
Query: 116 DCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIR 174
D E + C + +L +P + L L N + S+P F + L + LQ +
Sbjct: 90 DADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLG 149
Query: 175 HISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNS 234
+ +A GL NL L+L N + +L G F L L L +N ++R+ LF GL S
Sbjct: 150 SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS 209
Query: 235 LFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIG 294
L+ L++ N L LP + L + L GNR+ YL + F L L L RN +
Sbjct: 210 LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 269
Query: 295 FVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQ 354
+ F L L +L L N I ++P F LK L+ L+LS N + L ++ F L
Sbjct: 270 AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 329
Query: 355 LQSLDLERIEIPNINTRMFQPMKNLSHI 382
L+ L L I ++ R F+ + L +
Sbjct: 330 LRVLRLSHNAIASLRPRTFKDLHFLEEL 357
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/254 (28%), Positives = 111/254 (43%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N++ L D +F L + L N + + AF GL +L+ L L N + L+
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P +F L +L L L N + I +F L L L + N + A+ + L W
Sbjct: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+DL NR+ L TF L VL L N I + +TF L L EL L N I +L+
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSH 381
F+ L L+ L L N L + F L + ++L + N+ ++F+ + L
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 428
Query: 382 IYFKNFRYCSYAPH 395
++ + PH
Sbjct: 429 LHLEGSCLGRIRPH 442
Score = 79.7 bits (195), Expect = 9e-15
Identities = 50/162 (30%), Positives = 78/162 (48%), Gaps = 1/162 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
NV +++L N + +LP++VF KL + L+ +C+ I F GL L+ L+L N +
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
+ L +L L L N +T + RLF GL L +L + N L LP +
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQI-GFVPE 298
+ W+D+ NR++ L NS L L L N + F P+
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 562
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/181 (29%), Positives = 86/181 (47%)
Query: 214 LILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
L LD N ++ + F L+SL FL++ L +L Q + L + LE N+++ L
Sbjct: 117 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 176
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
TF +L L L N++ + + F L +L +L+L N++ L F+ L L++
Sbjct: 177 LGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRE 236
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA 393
L L+ N L YL F L +L+ LDL R + I +F + L +Y + A
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296
Query: 394 P 394
P
Sbjct: 297 P 297
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 109 bits (272), Expect = 1e-23
Identities = 75/243 (30%), Positives = 115/243 (47%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+ L L++N++ SL F L + L +N + + F GL +L L L N +
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
L F+ L L L+L N + + LF+GL L L + N L A+ + Q+P
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
+L + L+ N I + FL +L L L N++ + E TF L L L LS N I
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
Query: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMK 377
L P FKDL L++L L N + L + FE L QL+ L L+ ++ + F +
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Query: 378 NLS 380
N++
Sbjct: 363 NVA 365
Score = 109 bits (272), Expect = 1e-23
Identities = 85/301 (28%), Positives = 136/301 (45%), Gaps = 48/301 (15%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFF------------------- 182
L L +N + ++ VF++ +L+K++L N I ++ AF
Sbjct: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282
Query: 183 -----GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSL-- 235
GL L++L L+HN I +LRP FKDLH L L L N I ++++R F GL L
Sbjct: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342
Query: 236 --------------FFLSMVN--------NYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
FL + N N L LP+Q+ + +L+ + LEG+ + +
Sbjct: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
TF L LFL N + + E++ L L ELDL+SN +T L LF+ L L+
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA 393
L LS N L L + L++ LD+ + + + P+ L ++ +N ++
Sbjct: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT 522
Query: 394 P 394
P
Sbjct: 523 P 523
Score = 100 bits (249), Expect = 5e-21
Identities = 75/271 (27%), Positives = 116/271 (42%), Gaps = 24/271 (8%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N++ L +F +L+++ L N +R I F L LQ LYL+ N I +
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 258
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
PG F L L WL L N + + + F GL L L + +N + +L + + L
Sbjct: 259 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 318
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFV------------------------P 297
+ L NRI+ L +F L VL L NQ+ V P
Sbjct: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
E+ F L L L L + + + PH F L L++L L N L+ + + L +L
Sbjct: 379 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE 438
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
LDL ++ ++ R+FQ + L ++ R
Sbjct: 439 LDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 469
Score = 100 bits (248), Expect = 7e-21
Identities = 80/268 (29%), Positives = 122/268 (45%), Gaps = 1/268 (0%)
Query: 116 DCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIR 174
D E + C + +L +P + L L N + S+P F + L + LQ +
Sbjct: 52 DADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLG 111
Query: 175 HISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNS 234
+ +A GL NL L+L N + +L G F L L L +N ++R+ LF GL S
Sbjct: 112 SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS 171
Query: 235 LFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIG 294
L+ L++ N L LP + L + L GNR+ YL + F L L L RN +
Sbjct: 172 LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 231
Query: 295 FVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQ 354
+ F L L +L L N I ++P F LK L+ L+LS N + L ++ F L
Sbjct: 232 AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 291
Query: 355 LQSLDLERIEIPNINTRMFQPMKNLSHI 382
L+ L L I ++ R F+ + L +
Sbjct: 292 LRVLRLSHNAIASLRPRTFKDLHFLEEL 319
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/254 (28%), Positives = 111/254 (43%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L N++ L D +F L + L N + + AF GL +L+ L L N + L+
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P +F L +L L L N + I +F L L L + N + A+ + L W
Sbjct: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+DL NR+ L TF L VL L N I + +TF L L EL L N I +L+
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSH 381
F+ L L+ L L N L + F L + ++L + N+ ++F+ + L
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 390
Query: 382 IYFKNFRYCSYAPH 395
++ + PH
Sbjct: 391 LHLEGSCLGRIRPH 404
Score = 79.7 bits (195), Expect = 9e-15
Identities = 50/162 (30%), Positives = 78/162 (48%), Gaps = 1/162 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
NV +++L N + +LP++VF KL + L+ +C+ I F GL L+ L+L N +
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
+ L +L L L N +T + RLF GL L +L + N L LP +
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQI-GFVPE 298
+ W+D+ NR++ L NS L L L N + F P+
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/181 (29%), Positives = 86/181 (47%)
Query: 214 LILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
L LD N ++ + F L+SL FL++ L +L Q + L + LE N+++ L
Sbjct: 79 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 138
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
TF +L L L N++ + + F L +L +L+L N++ L F+ L L++
Sbjct: 139 LGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRE 198
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA 393
L L+ N L YL F L +L+ LDL R + I +F + L +Y + A
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 258
Query: 394 P 394
P
Sbjct: 259 P 259
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 107 bits (266), Expect = 5e-23
Identities = 73/222 (32%), Positives = 104/222 (46%), Gaps = 3/222 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L +NKI ++ F LK + +Q N + + AF+GL N++IL L+HN +T +
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
G L L L L N I RIS + L L + N+L L + LN
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK---TFSSLKNLGELDLSSNTIT 318
+ + NR+ Y+ + F SL L L N+I + E FS L L L L N I
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIR 399
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
++ F L L+ L+LS N +M L N F +K+LQ L L
Sbjct: 400 SITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 441
Score = 104 bits (259), Expect = 3e-22
Identities = 73/252 (28%), Positives = 122/252 (48%), Gaps = 4/252 (1%)
Query: 135 ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNH 194
++N + +L L +N+I ++P K+F K +L+ + L N I+++ F GL L+ L +
Sbjct: 190 LANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 248
Query: 195 NCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCA 254
N +T L G F L + L LD N +T I++ GL L L + N + +
Sbjct: 249 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 308
Query: 255 QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSS 314
+L+ +DL N + L +S+FL L L + N++ ++ + F L +L LDL +
Sbjct: 309 FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 368
Query: 315 NTIT---ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTR 371
N I+ E F L L++L L N + + K F L L+ LDL I ++
Sbjct: 369 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 428
Query: 372 MFQPMKNLSHIY 383
F MK L ++
Sbjct: 429 AFSQMKKLQQLH 440
Score = 97.4 bits (241), Expect = 4e-20
Identities = 73/271 (26%), Positives = 131/271 (48%), Gaps = 29/271 (10%)
Query: 121 ELECVNGDLKSVPM---ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHIS 177
E++ N +L+++P +S N+TLLSL N+I + + ++ L+ + L N I +
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL- 160
Query: 178 RKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFF 237
+ F L+ LYLN N +T++ PG F +L N+L
Sbjct: 161 -QTAFPALQLKYLYLNSNRVTSMEPGYFDNL-----------------------ANTLLV 196
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
L + N + A+P +M ++PQL ++L N+IK + TF +L L + RN + +
Sbjct: 197 LKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
+ F L N+ L L N +TE++ L +LQ+L+LS N + + + +E ++L
Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
LDL + ++ F + L+ ++ N R
Sbjct: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 346
Score = 93.2 bits (230), Expect = 8e-19
Identities = 61/204 (29%), Positives = 103/204 (50%), Gaps = 3/204 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L +++N + L D F + ++ + L HN + I++ +GL LQ L+L+ N I +
Sbjct: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 303
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P ++ +L+ L L N ++R+ F GL+ L L + NN + + + L
Sbjct: 304 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363
Query: 262 VDLEGNRIKYLT---NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTIT 318
+DL+ N I + N F D L L L N+I + +K F+ L L LDLS N I
Sbjct: 364 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 423
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLM 342
L + F +K LQ+L+L+++ L+
Sbjct: 424 SLQGNAFSQMKKLQQLHLNTSSLL 447
Score = 43.9 bits (102), Expect = 6e-04
Identities = 42/152 (27%), Positives = 68/152 (44%), Gaps = 28/152 (18%)
Query: 257 PQLNWV---DLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLS 313
P +WV DL NR+ ++ S+ SL + L N++ +P S N+ L L+
Sbjct: 71 PLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLA 129
Query: 314 SNTITELSPHLFKDLKLLQKLNLSSNPL--------------MYLHKNQFESLK------ 353
N I E+ P K+ + L+ L+LSSN + +YL+ N+ S++
Sbjct: 130 GNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDN 189
Query: 354 ---QLQSLDLERIEIPNINTRMFQPMKNLSHI 382
L L L R I I +MF+ + L H+
Sbjct: 190 LANTLLVLKLNRNRISAIPPKMFK-LPQLQHL 220
Score = 37.0 bits (84), Expect = 0.068
Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 88 TIFGTVHGNANSVALTQECFLKQYP--QCCDCKETELECVNGDLKSVPMISNNVTLLSLK 145
++ T+H N V+ +C + + D K E+ D+ + + L L+
Sbjct: 335 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQ 394
Query: 146 KNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLN 193
N+I S+ K F L+ + L N I + AF + LQ L+LN
Sbjct: 395 GNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 442
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 107 bits (266), Expect = 5e-23
Identities = 73/222 (32%), Positives = 104/222 (46%), Gaps = 3/222 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L +NKI ++ F LK + +Q N + + AF+GL N++IL L+HN +T +
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
G L L L L N I RIS + L L + N+L L + LN
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK---TFSSLKNLGELDLSSNTIT 318
+ + NR+ Y+ + F SL L L N+I + E FS L L L L N I
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIR 339
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
++ F L L+ L+LS N +M L N F +K+LQ L L
Sbjct: 340 SITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 381
Score = 104 bits (259), Expect = 3e-22
Identities = 73/252 (28%), Positives = 122/252 (48%), Gaps = 4/252 (1%)
Query: 135 ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNH 194
++N + +L L +N+I ++P K+F K +L+ + L N I+++ F GL L+ L +
Sbjct: 130 LANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188
Query: 195 NCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCA 254
N +T L G F L + L LD N +T I++ GL L L + N + +
Sbjct: 189 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 248
Query: 255 QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSS 314
+L+ +DL N + L +S+FL L L + N++ ++ + F L +L LDL +
Sbjct: 249 FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 308
Query: 315 NTIT---ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTR 371
N I+ E F L L++L L N + + K F L L+ LDL I ++
Sbjct: 309 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 368
Query: 372 MFQPMKNLSHIY 383
F MK L ++
Sbjct: 369 AFSQMKKLQQLH 380
Score = 97.4 bits (241), Expect = 4e-20
Identities = 73/271 (26%), Positives = 131/271 (48%), Gaps = 29/271 (10%)
Query: 121 ELECVNGDLKSVPM---ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHIS 177
E++ N +L+++P +S N+TLLSL N+I + + ++ L+ + L N I +
Sbjct: 42 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL- 100
Query: 178 RKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFF 237
+ F L+ LYLN N +T++ PG F +L N+L
Sbjct: 101 -QTAFPALQLKYLYLNSNRVTSMEPGYFDNL-----------------------ANTLLV 136
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
L + N + A+P +M ++PQL ++L N+IK + TF +L L + RN + +
Sbjct: 137 LKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
+ F L N+ L L N +TE++ L +LQ+L+LS N + + + +E ++L
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
LDL + ++ F + L+ ++ N R
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 286
Score = 93.2 bits (230), Expect = 8e-19
Identities = 61/204 (29%), Positives = 103/204 (50%), Gaps = 3/204 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L +++N + L D F + ++ + L HN + I++ +GL LQ L+L+ N I +
Sbjct: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P ++ +L+ L L N ++R+ F GL+ L L + NN + + + L
Sbjct: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
Query: 262 VDLEGNRIKYLT---NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTIT 318
+DL+ N I + N F D L L L N+I + +K F+ L L LDLS N I
Sbjct: 304 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 363
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLM 342
L + F +K LQ+L+L+++ L+
Sbjct: 364 SLQGNAFSQMKKLQQLHLNTSSLL 387
Score = 37.0 bits (84), Expect = 0.068
Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 88 TIFGTVHGNANSVALTQECFLKQYP--QCCDCKETELECVNGDLKSVPMISNNVTLLSLK 145
++ T+H N V+ +C + + D K E+ D+ + + L L+
Sbjct: 275 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQ 334
Query: 146 KNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLN 193
N+I S+ K F L+ + L N I + AF + LQ L+LN
Sbjct: 335 GNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLN 382
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 103 bits (256), Expect = 8e-22
Identities = 86/309 (27%), Positives = 146/309 (47%), Gaps = 7/309 (2%)
Query: 112 PQCCDCKETELECVNGDLKSVPMISNNVTL-LSLKKNKIHSLPDKVFIKYTKLKKIFLQH 170
P C C++ C + SVP ++ +L LSL+ N I L F +++L + L H
Sbjct: 35 PPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDH 94
Query: 171 NCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
N I + AF GL L+ L L+ N I L F L L L L N ++ + LF
Sbjct: 95 NQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFY 154
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPR 290
GL L L + +N L +P ++ L ++DL NR++ L + F L L L
Sbjct: 155 GLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEH 214
Query: 291 NQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFE 350
NQ+ + F L +L L L N I+ L+ + L+KL+L+ N + + FE
Sbjct: 215 NQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFE 274
Query: 351 SLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFK-NFRYCSYAPHVRICMPLTDGISSF 409
++ L+ L ++ ++ ++++++ +++L+ + N CS RIC L + SF
Sbjct: 275 TMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECS----ARIC-ALASWLGSF 329
Query: 410 EDLLANNIL 418
+ ++IL
Sbjct: 330 QGRWEHSIL 338
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 102 bits (255), Expect = 1e-21
Identities = 77/255 (30%), Positives = 123/255 (48%), Gaps = 4/255 (1%)
Query: 135 ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNH 194
+S ++ L L KN+I LP + F K +L ++ L N IR I F GL +L++L L
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244
Query: 195 NCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCA 254
N I+ L G F L ++ L L+ N + ++ GL +L L + NN + + ++ +
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304
Query: 255 QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSS 314
+L+ + L N + L + SL+VL L N I + E F L++L LDL
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
Query: 315 NTIT---ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTR 371
N I+ E + F L L KL L N + + K F L+ L+ L+L I ++
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD 424
Query: 372 MFQPMKNLSHIYFKN 386
F MKNL ++ +
Sbjct: 425 AFVKMKNLKELHISS 439
Score = 86.3 bits (212), Expect = 1e-16
Identities = 58/209 (27%), Positives = 107/209 (51%), Gaps = 3/209 (1%)
Query: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
N++ +L L++N I L D F +K+ + L++N + ++ + +GL L L+L++N
Sbjct: 235 NSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNS 294
Query: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
I + + +L L+L N +TR+ + L+SL L + +N + + + +
Sbjct: 295 IARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGL 354
Query: 257 PQLNWVDLEGNRIKYL---TNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLS 313
L +DL+ N I T+ F DSL+ L L N+I V ++ FS L+ L L+L
Sbjct: 355 RSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLG 414
Query: 314 SNTITELSPHLFKDLKLLQKLNLSSNPLM 342
N I + F +K L++L++SS+ +
Sbjct: 415 GNAIRSVQFDAFVKMKNLKELHISSDSFL 443
Score = 85.9 bits (211), Expect = 1e-16
Identities = 67/244 (27%), Positives = 117/244 (47%), Gaps = 3/244 (1%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+ + L N++ ++P + + + +FLQHN IR + +L++L L+ N I
Sbjct: 93 NLQEVYLNNNELTAVPS-LGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNI 151
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLN-SLFFLSMVNNYLEALPKQMCAQM 256
T +R F + L L N I + F GL+ SL L + N + LP + ++
Sbjct: 152 TEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVR-AFKL 210
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
P+L +DL NRI+ + TF +SL VL L RN I + + F L + L L N+
Sbjct: 211 PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNS 270
Query: 317 ITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPM 376
+ E++ L L +L+LS+N + +H+ + ++L L L + ++ +
Sbjct: 271 LVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAEL 330
Query: 377 KNLS 380
+LS
Sbjct: 331 SSLS 334
Score = 83.6 bits (205), Expect = 6e-16
Identities = 71/229 (31%), Positives = 109/229 (47%), Gaps = 2/229 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC-NLQILYLNHNC 196
++ +L L N I + + F +K++ L N I + AF GL +L L L+ N
Sbjct: 140 SLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNR 199
Query: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
IT L FK L +LT L L+ N I I F GLNSL L + N + L +
Sbjct: 200 ITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGL 258
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
+++ + LE N + + + + +L L L N I + K +S + L EL LS N
Sbjct: 259 SKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNN 318
Query: 317 ITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEI 365
+T L +L L L LS N + ++ + F+ L+ L+ LDL+ EI
Sbjct: 319 LTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
Score = 66.6 bits (161), Expect = 8e-11
Identities = 60/224 (26%), Positives = 95/224 (42%), Gaps = 3/224 (1%)
Query: 164 KKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITR 223
+ + L +N + I F L NLQ +YLN+N +T + P + + L L N I
Sbjct: 71 RSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRS 129
Query: 224 ISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCD-S 282
+ SL L + N + + P + ++L GNRI L F S
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRS 189
Query: 283 LTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLM 342
L L L +N+I +P + F L L +LDL+ N I + F+ L L+ L L N +
Sbjct: 190 LLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNIS 248
Query: 343 YLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKN 386
L F L ++ L LE + +N+ + L ++ N
Sbjct: 249 KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSN 292
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 102 bits (253), Expect = 2e-21
Identities = 80/276 (28%), Positives = 131/276 (47%), Gaps = 30/276 (10%)
Query: 112 PQCCDCKE--TELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFL 168
P C C +++ CV +L+ VP IS N LL+L +N+I +
Sbjct: 48 PSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQ----------------II 91
Query: 169 QHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRL 228
+ N +H+ +L+IL L+ N I T+ G F L L L L DN +T I
Sbjct: 92 KVNSFKHLR--------HLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGA 143
Query: 229 FTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDL-EGNRIKYLTNSTFLSCDSLTVLF 287
F L+ L L + NN +E++P ++P L +DL E R+ Y++ F +L L
Sbjct: 144 FVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLN 203
Query: 288 LPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKN 347
L + +P T L L ELDLS N ++ + P F+ L LQKL + + + + +N
Sbjct: 204 LAMCNLREIPNLT--PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERN 261
Query: 348 QFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIY 383
F++L+ L ++L + + +F P+ +L I+
Sbjct: 262 AFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIH 297
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 100 bits (250), Expect = 4e-21
Identities = 76/259 (29%), Positives = 116/259 (44%), Gaps = 1/259 (0%)
Query: 112 PQCCDCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQH 170
P+ C C + C + +P IS LSL+ N I L F +L ++L H
Sbjct: 35 PKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 171 NCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
N I + AF G+ L+ L L+ N IT L F + L L L N + + F
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFK 154
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPR 290
GL L L + +N L+ +P ++ L+++DL NR++ L+ + F L L L
Sbjct: 155 GLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEH 214
Query: 291 NQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFE 350
NQ + F L NL + L N I +S L L L+LS N + + F+
Sbjct: 215 NQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFK 274
Query: 351 SLKQLQSLDLERIEIPNIN 369
L LQ L+L+ ++ NI+
Sbjct: 275 CLPNLQKLNLDSNKLTNIS 293
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/172 (31%), Positives = 86/172 (50%)
Query: 214 LILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
L L N I ++ F GLN L +L + +NY+ ++ + + +L + L N+I YL
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
N TF +L L L N++ + + F L+ L L L SN++ + +F+D + L
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFK 385
L+L N L L +N F L +L+ L LE + IN F + NL IY +
Sbjct: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQ 237
Score = 80.5 bits (197), Expect = 5e-15
Identities = 64/215 (29%), Positives = 98/215 (45%), Gaps = 9/215 (4%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L NKI L +K F L+ + L +N ++ + + F GL L IL+L N + T+
Sbjct: 114 LILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP 173
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
+F+D L +L L N + +S+ F GL L L + +N + ++ L
Sbjct: 174 IRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRS 233
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L+ NRI+ ++ + SL L L N I + TF L NL +L+L SN +T +S
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNIS 293
Query: 322 PHLFKDLKLLQKLNLSSN---------PLMYLHKN 347
L + LS N PL Y KN
Sbjct: 294 QETVNAWISLISITLSGNMWECSRSICPLFYWLKN 328
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/152 (28%), Positives = 72/152 (47%)
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
LS+ N ++ L A + QL W+ L+ N I + F L L L N+I ++
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
KTF + NL LDLS N + L FK L+ L L+L SN L + F+ + L
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRY 389
LDL + +++ F + L ++ ++ ++
Sbjct: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQF 217
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/151 (29%), Positives = 74/151 (49%)
Query: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
+L L+ N + ++P +VF L + L +N +R +SR AF GL L+ L+L HN + +
Sbjct: 161 ILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Query: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLN 260
F L L + L N I ISQ L +SL L + N ++ + +P L
Sbjct: 221 NFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQ 280
Query: 261 WVDLEGNRIKYLTNSTFLSCDSLTVLFLPRN 291
++L+ N++ ++ T + SL + L N
Sbjct: 281 KLNLDSNKLTNISQETVNAWISLISITLSGN 311
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/172 (28%), Positives = 73/172 (42%), Gaps = 33/172 (19%)
Query: 126 NGDLKSVPMI----SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAF 181
+ LK+VP+ N+ L L N++ SL F KLK++ L+HN I+ F
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHF 225
Query: 182 FGLCNLQILYLNHNCITT------------------------LRPGIFKDLHQLTWLILD 217
L NL+ +YL N I + + PG FK L L L LD
Sbjct: 226 PRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLD 285
Query: 218 DNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWV-DLEGNR 268
N +T ISQ SL +++ N E + +C P W+ + +GN+
Sbjct: 286 SNKLTNISQETVNAWISLISITLSGNMWEC-SRSIC---PLFYWLKNFKGNK 333
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 100 bits (250), Expect = 4e-21
Identities = 76/259 (29%), Positives = 116/259 (44%), Gaps = 1/259 (0%)
Query: 112 PQCCDCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQH 170
P+ C C + C + +P IS LSL+ N I L F +L ++L H
Sbjct: 35 PKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 171 NCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
N I + AF G+ L+ L L+ N IT L F + L L L N + + F
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFK 154
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPR 290
GL L L + +N L+ +P ++ L+++DL NR++ L+ + F L L L
Sbjct: 155 GLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEH 214
Query: 291 NQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFE 350
NQ + F L NL + L N I +S L L L+LS N + + F+
Sbjct: 215 NQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFK 274
Query: 351 SLKQLQSLDLERIEIPNIN 369
L LQ L+L+ ++ NI+
Sbjct: 275 CLPNLQKLNLDSNKLTNIS 293
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/172 (31%), Positives = 86/172 (50%)
Query: 214 LILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLT 273
L L N I ++ F GLN L +L + +NY+ ++ + + +L + L N+I YL
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 274 NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
N TF +L L L N++ + + F L+ L L L SN++ + +F+D + L
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
Query: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFK 385
L+L N L L +N F L +L+ L LE + IN F + NL IY +
Sbjct: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQ 237
Score = 80.5 bits (197), Expect = 5e-15
Identities = 64/215 (29%), Positives = 98/215 (45%), Gaps = 9/215 (4%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L NKI L +K F L+ + L +N ++ + + F GL L IL+L N + T+
Sbjct: 114 LILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP 173
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
+F+D L +L L N + +S+ F GL L L + +N + ++ L
Sbjct: 174 IRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRS 233
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L+ NRI+ ++ + SL L L N I + TF L NL +L+L SN +T +S
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNIS 293
Query: 322 PHLFKDLKLLQKLNLSSN---------PLMYLHKN 347
L + LS N PL Y KN
Sbjct: 294 QETVNAWISLISITLSGNMWECSRSICPLFYWLKN 328
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/152 (28%), Positives = 72/152 (47%)
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
LS+ N ++ L A + QL W+ L+ N I + F L L L N+I ++
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
KTF + NL LDLS N + L FK L+ L L+L SN L + F+ + L
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDF 185
Query: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRY 389
LDL + +++ F + L ++ ++ ++
Sbjct: 186 LDLGYNRLRSLSRNAFAGLLKLKELHLEHNQF 217
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/151 (29%), Positives = 74/151 (49%)
Query: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
+L L+ N + ++P +VF L + L +N +R +SR AF GL L+ L+L HN + +
Sbjct: 161 ILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Query: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLN 260
F L L + L N I ISQ L +SL L + N ++ + +P L
Sbjct: 221 NFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQ 280
Query: 261 WVDLEGNRIKYLTNSTFLSCDSLTVLFLPRN 291
++L+ N++ ++ T + SL + L N
Sbjct: 281 KLNLDSNKLTNISQETVNAWISLISITLSGN 311
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/172 (28%), Positives = 73/172 (42%), Gaps = 33/172 (19%)
Query: 126 NGDLKSVPMI----SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAF 181
+ LK+VP+ N+ L L N++ SL F KLK++ L+HN I+ F
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHF 225
Query: 182 FGLCNLQILYLNHNCITT------------------------LRPGIFKDLHQLTWLILD 217
L NL+ +YL N I + + PG FK L L L LD
Sbjct: 226 PRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLD 285
Query: 218 DNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWV-DLEGNR 268
N +T ISQ SL +++ N E + +C P W+ + +GN+
Sbjct: 286 SNKLTNISQETVNAWISLISITLSGNMWEC-SRSIC---PLFYWLKNFKGNK 333
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 97.8 bits (242), Expect = 3e-20
Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 1/222 (0%)
Query: 139 VTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCIT 198
+T L L N I S+ F K ++K++ L N I + F + NL+ + L++N +
Sbjct: 91 LTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQ 150
Query: 199 TLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQ 258
L P +F L +LT L + N I + R+F SL FL + N L++L + A + +
Sbjct: 151 ALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK 210
Query: 259 LNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTIT 318
L + LE N + + + F SL L L RN++ V + + NL ++DLS N I
Sbjct: 211 LTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVS-SLDWVWNLEKMDLSGNEIE 269
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
+ PH+F+ + LQ L L SN L Y+ S K L S+ L
Sbjct: 270 YMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITL 311
Score = 97.4 bits (241), Expect = 4e-20
Identities = 78/271 (28%), Positives = 127/271 (46%), Gaps = 1/271 (0%)
Query: 112 PQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHN 171
PQ C C+ L C +L P + + LSL+ N + L F +L ++L HN
Sbjct: 40 PQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHN 99
Query: 172 CIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTG 231
I + AF L ++ L L+ N IT L F+ + L + L N + ++ LF G
Sbjct: 100 HICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHG 159
Query: 232 LNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRN 291
L L L M N ++ +P ++ L ++D+ N++K L ++F LT L L N
Sbjct: 160 LRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHN 219
Query: 292 QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFES 351
+ V F L +L L L N + + L + L+K++LS N + Y+ + FE+
Sbjct: 220 DLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSL-DWVWNLEKMDLSGNEIEYMEPHVFET 278
Query: 352 LKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
+ LQSL L+ + I R+ K+L+ I
Sbjct: 279 VPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
Score = 67.4 bits (163), Expect = 5e-11
Identities = 42/155 (27%), Positives = 75/155 (48%)
Query: 232 LNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRN 291
L+ L LS+ N L L + QL W+ L+ N I + F + L L N
Sbjct: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
Query: 292 QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFES 351
QI +P TF + NL +DLS N + L+P LF L+ L L++ +N + ++ F+
Sbjct: 124 QITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQD 183
Query: 352 LKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKN 386
+ L+ LD+ ++ ++ F + L+ ++ ++
Sbjct: 184 CRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEH 218
Score = 65.5 bits (158), Expect = 2e-10
Identities = 51/197 (25%), Positives = 91/197 (46%), Gaps = 23/197 (11%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L+L N+I LP+ F L+ + L +N ++ ++ F GL L L++ N I +
Sbjct: 118 LTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVP 177
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEAL-----PK-----Q 251
IF+D L +L + N + +++ F GL L L + +N L + P+
Sbjct: 178 VRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHS 237
Query: 252 MCAQ-------MPQLNWV------DLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPE 298
+C + + L+WV DL GN I+Y+ F + L L L N++ ++
Sbjct: 238 LCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEP 297
Query: 299 KTFSSLKNLGELDLSSN 315
+ +S K+L + L+ N
Sbjct: 298 RILNSWKSLTSITLAGN 314
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 96.3 bits (238), Expect = 9e-20
Identities = 71/242 (29%), Positives = 120/242 (49%), Gaps = 4/242 (1%)
Query: 135 ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNH 194
+S+++ ++ L +N++ +P K+F K L+ + L+ N I+ + F GL +L+ L +
Sbjct: 190 LSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQR 248
Query: 195 NCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCA 254
N I+ L+ G F L+ + L L+ N +TR+++ GL L L + N +E +
Sbjct: 249 NGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE 308
Query: 255 QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSS 314
+L+ +DL N++ L S F+ L L L N++ + + F L NL LDL +
Sbjct: 309 FCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRN 368
Query: 315 NTIT---ELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTR 371
N I+ E + F L L KL L N + + K F L+ L+ LDL I +I
Sbjct: 369 NEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQEN 428
Query: 372 MF 373
F
Sbjct: 429 AF 430
Score = 90.9 bits (224), Expect = 4e-18
Identities = 58/207 (28%), Positives = 104/207 (50%), Gaps = 3/207 (1%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L +++N I L D F ++++ L+HN + +++ +GL LQ LY++ N I +
Sbjct: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
P ++ +L+ L L N +TR+ + F GL+ L L++ +N + + + + L
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
Query: 262 VDLEGNRIKYL---TNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTIT 318
+DL N I + + F SLT L L NQI + +K F L++L LDL++N I
Sbjct: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM 423
Query: 319 ELSPHLFKDLKLLQKLNLSSNPLMYLH 345
+ + F L + + +S+ L H
Sbjct: 424 SIQENAFSQTHLKELILNTSSLLCDCH 450
Score = 90.5 bits (223), Expect = 5e-18
Identities = 70/265 (26%), Positives = 125/265 (47%), Gaps = 28/265 (10%)
Query: 121 ELECVNGDLKSVPMI---SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHIS 177
E++ +L +P ++N+TLLSL N I + + Y L+ + L N I I
Sbjct: 101 EVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIK 160
Query: 178 RKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFF 237
+F + L+ L L++N ITTL G F +L +SL
Sbjct: 161 TSSFPRM-QLKYLNLSNNRITTLEAGCFDNLS-----------------------SSLLV 196
Query: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
+ + N + +P ++ ++P L +++L+ NRIK + TF DSL L + RN I +
Sbjct: 197 VKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK 255
Query: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
+ F L N+ EL+L N +T ++ L++LQ+L +S N + + + +E ++L
Sbjct: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
Query: 358 LDLERIEIPNINTRMFQPMKNLSHI 382
LDL ++ ++ F + L +
Sbjct: 316 LDLSYNQLTRLDESAFVGLSLLERL 340
Score = 90.1 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 5/223 (2%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
++ L LK+N+I + F L+ + +Q N I + AFFGL N++ L L HN +
Sbjct: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
T + G L L L + N I RIS + L L + N L L + +
Sbjct: 276 TRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLS 335
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPE---KTFSSLKNLGELDLSS 314
L ++L NR+ ++ + F +L L L N+I + E + F+ L +L +L L
Sbjct: 336 LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQG 395
Query: 315 NTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFES--LKQL 355
N I ++ F L+ L+ L+L++N +M + +N F LK+L
Sbjct: 396 NQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKEL 438
Score = 32.0 bits (71), Expect = 2.2
Identities = 29/103 (28%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 113 QCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNC 172
Q D + E+ D ++T L L+ N+I S+ K FI L+ + L +N
Sbjct: 362 QTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNA 421
Query: 173 IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLI 215
I I A F +L+ L LN + + D H L WL+
Sbjct: 422 IMSIQENA-FSQTHLKELILNTS-------SLLCDCH-LKWLL 455
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 95.1 bits (235), Expect = 2e-19
Identities = 85/310 (27%), Positives = 136/310 (43%), Gaps = 8/310 (2%)
Query: 112 PQCCDCKETELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQH 170
P+ C C+ + C + L+ +P IS LSL+ N + L F +L ++L H
Sbjct: 35 PKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDH 94
Query: 171 NCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
N I +I AF G+ L+ L L+ N I+ F+ + L L L N + + F
Sbjct: 95 NHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFR 154
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPR 290
GL L L + +N L +P ++ L +DL NRI+ L + F L L L
Sbjct: 155 GLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEH 214
Query: 291 NQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPL-MYLHKNQF 349
NQ + F L +L L L N I+ + + LQ+L+LS N + + + F
Sbjct: 215 NQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVF 274
Query: 350 ESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFK-NFRYCSYAPHVRICMPLTDGISS 408
+ + LQ L+L+ ++ I + +L+ I N CS R L + + S
Sbjct: 275 QCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECS-----RNICSLVNWLKS 329
Query: 409 FEDLLANNIL 418
F+ L N I+
Sbjct: 330 FKGLRENTII 339
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 94.7 bits (234), Expect = 3e-19
Identities = 69/217 (31%), Positives = 102/217 (47%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L L +NKI LP + K L+++FL HN +R I + F L NLQ L LN N + L
Sbjct: 103 LRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLP 162
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
+F +L L L L N +T + + L L L + +N L +L + + L
Sbjct: 163 ASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTE 222
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ N I+ + F +L+ L L RN + F+P F NL L L N + EL
Sbjct: 223 LQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELP 282
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSL 358
LF ++ LQ+L L+ L L F +L +L+ L
Sbjct: 283 GVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYL 319
Score = 91.7 bits (226), Expect = 2e-18
Identities = 70/241 (29%), Positives = 105/241 (43%)
Query: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
L + + I ++ F KLK + L N I H+ + L+ L+L+HN + +
Sbjct: 79 LMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGID 138
Query: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
+F+ L L L L+ N + + LFT L +L L + N L LPK + +L
Sbjct: 139 QNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLER 198
Query: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
+ L NR+ L + S +LT L RN I + F L NL L LS N + L
Sbjct: 199 LLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLP 258
Query: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSH 381
LF L L L NPL L F + LQ L L R ++ + F+ + L +
Sbjct: 259 SALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRY 318
Query: 382 I 382
+
Sbjct: 319 L 319
Score = 79.0 bits (193), Expect = 2e-14
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 1/246 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N+ L+L +N++ LP +F LK + L N + H+ + L+ L L+ N +
Sbjct: 147 NLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
Query: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
+L G+ L LT L N I I+ F L +L L++ N+L LP +
Sbjct: 207 VSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSH 266
Query: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLS-SNT 316
L + L N + L F L L+L R Q+ +P F +L L L ++ S
Sbjct: 267 NLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPR 326
Query: 317 ITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPM 376
++ L F+ L LQ L L SN L L L +L+ + L R + + +F+ +
Sbjct: 327 LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNL 386
Query: 377 KNLSHI 382
+L +
Sbjct: 387 SSLESV 392
Score = 75.9 bits (185), Expect = 1e-13
Identities = 53/180 (29%), Positives = 91/180 (50%), Gaps = 1/180 (0%)
Query: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
N++ L+L +N + LP +F+ L + L N + + F + LQ L+LN +
Sbjct: 243 NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQL 302
Query: 198 TTLRPGIFKDLHQLTWLILDDNP-ITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
TL F++L +L +L + +P ++ + Q F GL L L++ +N L ALP + +
Sbjct: 303 RTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGL 362
Query: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
+L V L NR++ L + F + SL + L NQ+ +P F +L L E+ L N+
Sbjct: 363 GKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/171 (25%), Positives = 82/171 (47%)
Query: 224 ISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSL 283
+ + F+G+ L L + ++++ A+ + + +L + L N+I +L + L
Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
Query: 284 TVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMY 343
LFL N + + + F L NL EL L+ N + L LF +L+ L+ L+LS N L +
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
Query: 344 LHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAP 394
L K + +L+ L L + ++++ + + L+ + F S AP
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAP 235
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/157 (29%), Positives = 76/157 (48%), Gaps = 25/157 (15%)
Query: 136 SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHN--------CIRHISRK-------- 179
S+N+TLL+L +N + LP +F + L++++L R++SR
Sbjct: 265 SHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLS 324
Query: 180 ---------AFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFT 230
AF GL LQ+L L+ N +T L G+ + L +L + L N + + + LF
Sbjct: 325 PRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFR 384
Query: 231 GLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN 267
L+SL + + +N LE LP + +P+L V L N
Sbjct: 385 NLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.329 0.142 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,341,715
Number of Sequences: 37866
Number of extensions: 1143919
Number of successful extensions: 6564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 435
Number of HSP's that attempted gapping in prelim test: 3691
Number of HSP's gapped (non-prelim): 1977
length of query: 754
length of database: 18,247,518
effective HSP length: 110
effective length of query: 644
effective length of database: 14,082,258
effective search space: 9068974152
effective search space used: 9068974152
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.