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Search of human proteins with 18390333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2
[Homo sapiens]
(302 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2 ... 623 e-179
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 602 e-172
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 332 2e-91
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 191 7e-49
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 67 1e-11
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 63 4e-10
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 63 4e-10
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens] 56 4e-08
gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Ho... 55 8e-08
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 55 1e-07
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 53 4e-07
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 52 5e-07
gi|34304381 inversin isoform a [Homo sapiens] 52 6e-07
gi|34304379 inversin isoform b [Homo sapiens] 52 6e-07
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 52 8e-07
gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens] 51 1e-06
gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens] 51 1e-06
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 51 1e-06
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 50 2e-06
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 50 2e-06
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 50 2e-06
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 50 2e-06
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 50 2e-06
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 49 4e-06
gi|24041035 notch 2 preproprotein [Homo sapiens] 49 5e-06
gi|16975496 cortactin binding protein 2 [Homo sapiens] 49 7e-06
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 48 1e-05
gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [H... 47 2e-05
gi|148833508 notch1 preproprotein [Homo sapiens] 47 3e-05
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 47 3e-05
>gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2
[Homo sapiens]
Length = 302
Score = 623 bits (1607), Expect = e-179
Identities = 302/302 (100%), Positives = 302/302 (100%)
Query: 1 MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 60
MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD
Sbjct: 1 MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 60
Query: 61 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLL 120
QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLL
Sbjct: 61 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLL 120
Query: 121 LRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTV 180
LRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTV
Sbjct: 121 LRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTV 180
Query: 181 EGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIH 240
EGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIH
Sbjct: 181 EGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIH 240
Query: 241 FILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 300
FILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG
Sbjct: 241 FILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 300
Query: 301 TW 302
TW
Sbjct: 301 TW 302
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 602 bits (1552), Expect = e-172
Identities = 292/293 (99%), Positives = 292/293 (99%)
Query: 10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 69
L ALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD
Sbjct: 131 LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
Query: 70 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY 129
HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY
Sbjct: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY 250
Query: 130 FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 189
FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK
Sbjct: 251 FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 310
Query: 190 DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL 249
DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL
Sbjct: 311 DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL 370
Query: 250 KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW 302
KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
Sbjct: 371 KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW 423
Score = 34.7 bits (78), Expect = 0.11
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 12/85 (14%)
Query: 47 LLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---N 103
LLI G DVN + ++AL+ A VKL+L +GA P+
Sbjct: 4 LLINYGADVNLRCA---------NERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFT 54
Query: 104 CLQIALRMGNYELISLLLRHGANVN 128
L +A + G+ E++ +LLR GAN +
Sbjct: 55 PLALAAQSGHTEIMEMLLRKGANAH 79
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 332 bits (851), Expect = 2e-91
Identities = 166/293 (56%), Positives = 208/293 (70%), Gaps = 9/293 (3%)
Query: 12 ALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHR 71
ALK LIPVT AI++SG++P+H AA G + QCLELLI+ GFDVN +L I++ YDD R
Sbjct: 291 ALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDER 350
Query: 72 KSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN-YF 130
K+ALYF VSN+D+ ++LL+AGA PN DP+NCL +A+R NYE++ LLL HGANVN YF
Sbjct: 351 KTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYF 410
Query: 131 CRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSY--------TVEG 182
VN FPS +QY L DEVMLR+LLN GY E CFDC HGD S+ + G
Sbjct: 411 MHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPG 470
Query: 183 WTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFI 242
WTS VIKD FCE IT+ W++HL G+V RV++DY+D V +C+KLK+ L+ Q W EI I
Sbjct: 471 WTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQI 530
Query: 243 LTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQ 295
L NP SLKHLCRLKIR+ MG L P + LPLP ++ Y+L+KEYDLYGQ
Sbjct: 531 LENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQ 583
Score = 37.4 bits (85), Expect = 0.016
Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 16/138 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+ G P+H A Q LE+++ A + + K D ++ L AV + +
Sbjct: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF-----KTCDG--ETPLTLAVKAGLVEN 126
Query: 87 VKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFC--RVNPLHFPSA 141
V+ LL G PN L IA++ G+Y+++S L++H +++ C R + +H A
Sbjct: 127 VRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMH--EA 184
Query: 142 LQYTLKDEVMLRMLLNYG 159
+ KD V L LL +G
Sbjct: 185 AKQGRKDIVAL--LLKHG 200
Score = 30.0 bits (66), Expect = 2.6
Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 45 LELLIQAGF--DVNFMLDQRINKHY-DDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP 101
L L ++AG +V +L++ + + +D ++ L AV V L+ +Q
Sbjct: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPC 174
Query: 102 V---NCLQIALRMGNYELISLLLRHGANVN 128
V + + A + G ++++LLL+HG NV+
Sbjct: 175 VKRWSAMHEAAKQGRKDIVALLLKHGGNVH 204
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 191 bits (485), Expect = 7e-49
Identities = 104/285 (36%), Positives = 164/285 (57%), Gaps = 10/285 (3%)
Query: 11 RALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDH 70
R +++L+PVT I++SG+SP+H AA H + LE L+ A FDVN L + Y+D
Sbjct: 303 RIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDR 362
Query: 71 RKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYF 130
R SALYFAV N+++ + +LLL GA PN+D ++ L +A+R G + LLL HGAN++ +
Sbjct: 363 RSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY 422
Query: 131 CRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHP--SYTVEGWTSTVI 188
+P FP+ + + +K +L+ L++ G D E CF C +G+ HP +
Sbjct: 423 IATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPA 482
Query: 189 KD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFIL 243
D +FCE ++ + +G ++ V+LDYV V++CS+LK + W+ I
Sbjct: 483 ADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKA 542
Query: 244 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYK 288
PR L HLCRL++RK +G+ ++ + LPLP RL Y+ Y+
Sbjct: 543 EPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYE 584
Score = 45.8 bits (107), Expect = 5e-05
Identities = 43/137 (31%), Positives = 61/137 (44%), Gaps = 17/137 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
GI+P+ AA + L L + G D+N SALY A N V+
Sbjct: 223 GITPLFVAAQSGQLEALRFLAKYGADINTQASDNA---------SALYEACKNEHEEVVE 273
Query: 89 LLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNY-FCRVNPLHFPSALQY 144
LLS GA N+D + L IA + GNY ++ +LL + V+PLH + +
Sbjct: 274 FLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNH 333
Query: 145 TLKDEVMLRMLLNYGYD 161
DEV L LL+ +D
Sbjct: 334 ---DEV-LEALLSARFD 346
Score = 40.8 bits (94), Expect = 0.001
Identities = 40/135 (29%), Positives = 62/135 (45%), Gaps = 12/135 (8%)
Query: 1 MLKCILKFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 59
++K I ALK +I +LA + G P+H AA CL++L +A +
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA---YPGTI 117
Query: 60 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP---NQDPVNCLQIALRMGNYEL 116
DQR + ++A+Y A L + LL AGA P N+ L A N E
Sbjct: 118 DQRTLQE-----ETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Query: 117 ISLLLRHGANVNYFC 131
+ +L++H A+ N+ C
Sbjct: 173 VKILVQHNADTNHRC 187
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 67.4 bits (163), Expect = 1e-11
Identities = 69/275 (25%), Positives = 121/275 (44%), Gaps = 36/275 (13%)
Query: 31 SPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL 90
+P+ AA H C++ LI+ G +V+ + D ++ALY AV N L S ++L
Sbjct: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLV---------DVKGQTALYVAVVNGHLESTQIL 130
Query: 91 LSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLK 147
L AGA PN + A R+G +++ L+R+GA+V+ + P P L
Sbjct: 131 LEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQP-RFSRRLT 189
Query: 148 DEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTST---------VIKDTKF---CE 195
V+ + ++ Y +CF +P + G +T + D CE
Sbjct: 190 SLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCE 249
Query: 196 VITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSLKHLCRL 255
+S L + V + + + K + ++ E + PR+L LCR+
Sbjct: 250 AAFVSLLVEFGANLNLVKWESLGP-ESRGRRKVDPEALQVFKEARSV---PRTLLCLCRV 305
Query: 256 KIRKCMG--RLHLRCPVFMSFLPLPNRLKAYVLYK 288
+R+ +G RLHL + LPLP+ +K ++L++
Sbjct: 306 AVRRALGKHRLHL-----IPSLPLPDPIKKFLLHE 335
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 62.8 bits (151), Expect = 4e-10
Identities = 75/284 (26%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 80
DL + S P+H AA H + L+LLI N D +NK S +Y AV
Sbjct: 166 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPL---TNRACDTGLNK------VSPVYSAVF 216
Query: 81 NSDLSSVKLLLSAGALPN---------QDPVNCLQIALRMGNYELISLLLRHGANVNYFC 131
+++LL G P+ PV C+ + ++++LL++GA
Sbjct: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPV-CMAFQKDCEFFGIVNILLKYGA------ 269
Query: 132 RVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 189
++N LH L+Y LR + G H K Y + W ++
Sbjct: 270 QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKY--KEWLPHLLV 327
Query: 190 DTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQG--IWSEIHFILTN 245
F +I L SW+ +S + L++ + + ++ +L + W I T
Sbjct: 328 -AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATV 386
Query: 246 PRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 289
P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 387 P-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
Score = 44.7 bits (104), Expect = 1e-04
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 10/96 (10%)
Query: 74 ALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN-- 128
AL+ A S V++LL AGA PN + L +A+ G +++ LLL+HGANVN
Sbjct: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
Query: 129 -YFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 163
C N LH S + + ++++LL G + E
Sbjct: 69 HSMCGWNSLHQASFQE----NAEIIKLLLRKGANKE 100
Score = 44.3 bits (103), Expect = 1e-04
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 13/102 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G +H AA+ H + +++L++AG D N + + L+ AV N + ++
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLE---------ETTPLFLAVENGQIDVLR 56
Query: 89 LLLSAGALPNQDPVNC----LQIALRMGNYELISLLLRHGAN 126
LLL GA N C L A N E+I LLLR GAN
Sbjct: 57 LLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 98
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Query: 39 GAHPQC-LELLIQAGFDVN-----FMLDQRINKH-YDDHRKSALYFAVSNSDLSSVKLLL 91
G+H C L QA F N +L + NK DD + L+ A L S+ +L+
Sbjct: 67 GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 126
Query: 92 SAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVN----PLHFPSALQY 144
S+GA N D L IA + G+ + + LLL GA+ + +C + P+H + + +
Sbjct: 127 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
Query: 145 TLKDEVMLRMLLNYGYDT 162
T K +L L N DT
Sbjct: 187 T-KILDLLIPLTNRACDT 203
Score = 36.2 bits (82), Expect = 0.037
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 22/146 (15%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
GI+P+ AA + L +LI +G +VN Q ++K + L+ A V+
Sbjct: 106 GITPLFVAAQYGKLESLSILISSGANVNC---QALDK------ATPLFIAAQEGHTKCVE 156
Query: 89 LLLSAGALP----NQDPVNC-LQIALRMGNYELISLL--LRHGANVNYFCRVNPLHFPSA 141
LLLS+GA P N+D + A +MG+ +++ LL L + A +V+P++ SA
Sbjct: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY--SA 214
Query: 142 LQYTLKDEVMLRMLLNYGY--DTERC 165
+ +D L +LL GY D + C
Sbjct: 215 VFGGHED--CLEILLRNGYSPDAQAC 238
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 62.8 bits (151), Expect = 4e-10
Identities = 75/284 (26%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 80
DL + S P+H AA H + L+LLI N D +NK S +Y AV
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPL---TNRACDTGLNK------VSPVYSAVF 289
Query: 81 NSDLSSVKLLLSAGALPN---------QDPVNCLQIALRMGNYELISLLLRHGANVNYFC 131
+++LL G P+ PV C+ + ++++LL++GA
Sbjct: 290 GGHEDCLEILLRNGYSPDAQACLVFGFSSPV-CMAFQKDCEFFGIVNILLKYGA------ 342
Query: 132 RVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 189
++N LH L+Y LR + G H K Y + W ++
Sbjct: 343 QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKY--KEWLPHLLV 400
Query: 190 DTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQG--IWSEIHFILTN 245
F +I L SW+ +S + L++ + + ++ +L + W I T
Sbjct: 401 -AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATV 459
Query: 246 PRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 289
P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 460 P-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 16/141 (11%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G P+H AA +CL++LI A N++ + AL+ A S V+
Sbjct: 43 GWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGF------CALHLAASQGHWKIVQ 96
Query: 89 LLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN---YFCRVNPLHFPSAL 142
+LL AGA PN + L +A+ G +++ LLL+HGANVN C N LH S
Sbjct: 97 ILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQ 156
Query: 143 QYTLKDEVMLRMLLNYGYDTE 163
+ + ++++LL G + E
Sbjct: 157 E----NAEIIKLLLRKGANKE 173
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Query: 39 GAHPQC-LELLIQAGFDVN-----FMLDQRINKH-YDDHRKSALYFAVSNSDLSSVKLLL 91
G+H C L QA F N +L + NK DD + L+ A L S+ +L+
Sbjct: 140 GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 199
Query: 92 SAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVN----PLHFPSALQY 144
S+GA N D L IA + G+ + + LLL GA+ + +C + P+H + + +
Sbjct: 200 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
Query: 145 TLKDEVMLRMLLNYGYDT 162
T K +L L N DT
Sbjct: 260 T-KILDLLIPLTNRACDT 276
Score = 36.2 bits (82), Expect = 0.037
Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 22/146 (15%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
GI+P+ AA + L +LI +G +VN Q ++K + L+ A V+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNC---QALDK------ATPLFIAAQEGHTKCVE 229
Query: 89 LLLSAGALP----NQDPVNC-LQIALRMGNYELISLL--LRHGANVNYFCRVNPLHFPSA 141
LLLS+GA P N+D + A +MG+ +++ LL L + A +V+P++ SA
Sbjct: 230 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY--SA 287
Query: 142 LQYTLKDEVMLRMLLNYGY--DTERC 165
+ +D L +LL GY D + C
Sbjct: 288 VFGGHED--CLEILLRNGYSPDAQAC 311
>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
Length = 288
Score = 55.8 bits (133), Expect = 4e-08
Identities = 76/289 (26%), Positives = 113/289 (39%), Gaps = 83/289 (28%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
+ P+HCA + C+ELL++ G +VN + D + ++AL++A + D + V++
Sbjct: 54 LKPLHCACMVSDADCVELLLEKGAEVNAL---------DGYNRTALHYA-AEKDEACVEV 103
Query: 90 LLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCRVN--PLHFPS---- 140
LL GA PN N L A N E + LL GA+VN N PL + +
Sbjct: 104 LLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGN 163
Query: 141 ------ALQYTLKDEVM----------LRMLLNYGYDTER---CFDCPHGDKVHPSYTVE 181
L Y + V+ L LL G TE+ CF+ H H
Sbjct: 164 LESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKN 223
Query: 182 G-WTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIH 240
G V +D + CE +T+ +CS
Sbjct: 224 GTMPREVARDPQLCEKLTV----------------------LCSA--------------- 246
Query: 241 FILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 289
P +LK L R +R+ +G +L P + LPLP LK Y+L E
Sbjct: 247 -----PGTLKTLARYAVRRSLGLQYL--PDAVKGLPLPASLKEYLLLLE 288
>gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 839
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/111 (35%), Positives = 57/111 (51%), Gaps = 13/111 (11%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKS----ALYFAVSNSDL 84
G++P+ A A +++LI AG +++ + +H H S +L FAV + +
Sbjct: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
Query: 85 SSVKLLLSAGALPNQDPVNC---------LQIALRMGNYELISLLLRHGAN 126
S V+LLL AGA VN LQ+A GNYEL+SLLL GA+
Sbjct: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/138 (27%), Positives = 69/138 (50%), Gaps = 13/138 (9%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
Q+ SP+H AA H +L+QAG +++ + +++ L A N+ L +
Sbjct: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTC---------SEDQRTPLMEAAENNHLEA 821
Query: 87 VKLLLSAGAL---PNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQ 143
VK L+ AGAL + + CL +A + G+YE++ LL +G ++ C+ + P
Sbjct: 822 VKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNG-QMDVNCQDDGGWTPMIWA 880
Query: 144 YTLKDEVMLRMLLNYGYD 161
K ++++LL+ G D
Sbjct: 881 TEYKHVDLVKLLLSKGSD 898
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 52.8 bits (125), Expect = 4e-07
Identities = 64/261 (24%), Positives = 113/261 (43%), Gaps = 40/261 (15%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
+SP+H A G H C+++L++ G VN + D H + L+ A + V L
Sbjct: 70 VSPLHEACLGGHLSCVKILLKHGAQVNGVT-------ADWH--TPLFNACVSGSWDCVNL 120
Query: 90 LLSAGA--LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLK 147
LL GA P D + + A R G+ E ++ L+ +G N+++ +++ L P L +
Sbjct: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDH--KISHLGTPLYLACENQ 178
Query: 148 DEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSG 207
++ LL G D + + P + V S + C ++
Sbjct: 179 QRACVKKLLESGADVNQ-----GKGQDSPLHAVARTASEELA----CLLMDFGADTQAKN 229
Query: 208 KVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSLKHLCRLKIRKCMG-RLHL 266
+ ++ V ++L L+++G P SL LCRL+IRKC G + H
Sbjct: 230 AEGKRPVELVPPESPLAQL--FLEREG-----------PPSLMQLCRLRIRKCFGIQQHH 276
Query: 267 RCPVFMSFLPLPNRLKAYVLY 287
+ ++ L LP LK ++L+
Sbjct: 277 K----ITKLVLPEDLKQFLLH 293
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 52.4 bits (124), Expect = 5e-07
Identities = 76/349 (21%), Positives = 128/349 (36%), Gaps = 90/349 (25%)
Query: 10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 69
+ L +L+ + +G +P+H A A+ C+++L G +N Y
Sbjct: 88 VECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNC---------YSL 138
Query: 70 HRKSALYFAVSNSDLSSVKLLLSAGA-----LPNQDPVNCLQIALRMGNYELISLLLRHG 124
+AL+F + S + K L+ GA NQD L A G EL++ + HG
Sbjct: 139 SGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHG 198
Query: 125 ANVNYFCRVNP-LHFPSAL-----------QYTLKDEVMLRMLLNYGYDT---------- 162
A V+ VN + P A+ +Y+ + ++ RMLL+Y +
Sbjct: 199 AIVD---SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
Query: 163 --ERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVI----------------------- 197
+ ++C H V +E + D C I
Sbjct: 256 LHKAAWNCDH---VLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLL 312
Query: 198 -------------TLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGI---WSEIHF 241
+ H K + V+++ + +R +K + + + W H
Sbjct: 313 NHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHS 372
Query: 242 ILT----NPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVL 286
+ T +PR+L HL R IR+ LH RC + L LP LK Y+L
Sbjct: 373 LFTVCCNSPRTLMHLSRCAIRR---TLHNRCHRAIPLLSLPLSLKKYLL 418
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 52.0 bits (123), Expect = 6e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 14/103 (13%)
Query: 28 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 87
+G +P+ CAA G + C+ +L++ D N D ++AL+++ +N L ++
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLMENNADPNIQ---------DKEGRTALHWSCNNGYLDAI 505
Query: 88 KLLLSAGALPNQ-----DPVNCLQIALRMGNYELISLLLRHGA 125
KLLL A PNQ + L AL +E+I +L HGA
Sbjct: 506 KLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 32.0 bits (71), Expect = 0.69
Identities = 28/99 (28%), Positives = 39/99 (39%), Gaps = 11/99 (11%)
Query: 31 SPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL 90
S VH AA L+ LI + + D ++ L + V L L
Sbjct: 16 SQVHAAAVNGDKGALQRLIVG--------NSALKDKEDQFGRTPLMYCVLADRLDCADAL 67
Query: 91 LSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGAN 126
L AGA N+ + L +A + GNY + LLL AN
Sbjct: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106
Score = 28.9 bits (63), Expect = 5.8
Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 12/99 (12%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
Q G +P+ C + L++AG DVN D +++AL+ A +
Sbjct: 46 QFGRTPLMYCVLADRLDCADALLKAGADVN---------KTDHSQRTALHLAAQKGNYRF 96
Query: 87 VKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLR 122
+KLLL+ A + + + L + R + + ++LLL+
Sbjct: 97 MKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 52.0 bits (123), Expect = 6e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 14/103 (13%)
Query: 28 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 87
+G +P+ CAA G + C+ +L++ D N D ++AL+++ +N L ++
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLMENNADPNIQ---------DKEGRTALHWSCNNGYLDAI 505
Query: 88 KLLLSAGALPNQ-----DPVNCLQIALRMGNYELISLLLRHGA 125
KLLL A PNQ + L AL +E+I +L HGA
Sbjct: 506 KLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 32.0 bits (71), Expect = 0.69
Identities = 28/99 (28%), Positives = 39/99 (39%), Gaps = 11/99 (11%)
Query: 31 SPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL 90
S VH AA L+ LI + + D ++ L + V L L
Sbjct: 16 SQVHAAAVNGDKGALQRLIVG--------NSALKDKEDQFGRTPLMYCVLADRLDCADAL 67
Query: 91 LSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGAN 126
L AGA N+ + L +A + GNY + LLL AN
Sbjct: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106
Score = 28.9 bits (63), Expect = 5.8
Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 12/99 (12%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
Q G +P+ C + L++AG DVN D +++AL+ A +
Sbjct: 46 QFGRTPLMYCVLADRLDCADALLKAGADVN---------KTDHSQRTALHLAAQKGNYRF 96
Query: 87 VKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLR 122
+KLLL+ A + + + L + R + + ++LLL+
Sbjct: 97 MKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 51.6 bits (122), Expect = 8e-07
Identities = 79/293 (26%), Positives = 115/293 (39%), Gaps = 56/293 (19%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G + +H A A H C+ +L+ AG D N D K L+ L +
Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIA---------DQDGKRPLHLCRGPGTLECAE 243
Query: 89 LLLSAGALPN----QDPVNCLQIALRMGNYELISLLLRHGA-----NVNYF------CRV 133
LLL GA + ++ L +A R+G+ EL LLLR GA N + C V
Sbjct: 244 LLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDV 303
Query: 134 NPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSY-TVEGWTSTVIKDTK 192
A T + + +LL+ G D D DK P + + V++
Sbjct: 304 RCQSITDAEATTARCLQLCSLLLSAGADA----DAADQDKQRPLHLACRRGHAAVVELLL 359
Query: 193 FCEVI--TLSWLQH------LSG----------KVVRVMLDYVDQVRICSKLKAVLQK-- 232
C V T+ + H L G VVR +L++ VR+ L K
Sbjct: 360 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH-GAVRV---WPGALPKKH 415
Query: 233 QGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYV 285
Q +S + ++ PRSL+HL R +R L P + LPLP RL Y+
Sbjct: 416 QRFYSSLFALVRQPRSLQHLSRCALR---SHLEGSLPQALPRLPLPPRLLRYL 465
Score = 42.4 bits (98), Expect = 5e-04
Identities = 47/174 (27%), Positives = 70/174 (40%), Gaps = 33/174 (18%)
Query: 31 SPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL 90
+P+H AA+ H + L LL++ +R ++AL+ A + + V +L
Sbjct: 163 TPLHVAASRGHTEVLRLLLR----------RRARPDSAPGGRTALHEACAAGHTACVHVL 212
Query: 91 LSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFC---RVNPLHFPSALQY 144
L AGA PN QD L + G E LLLR GA V+ PLH + L +
Sbjct: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
Query: 145 TLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVIT 198
+++LR CP + EGWT + C+ IT
Sbjct: 273 VELADLLLRR-----------GACP------DARNAEGWTPLLAACDVRCQSIT 309
>gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens]
Length = 641
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/138 (28%), Positives = 67/138 (48%), Gaps = 12/138 (8%)
Query: 1 MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 60
ML C ++ L+ + + + G++P+ A +++L+ AG D+N +
Sbjct: 113 MLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVV 172
Query: 61 QRINKHYDDHRKS----ALYFAVSNSDLSSVKLLLSAGALPNQDPVNC--------LQIA 108
+K+ H ++ AL FAV + + V+LLL AGA + LQ+A
Sbjct: 173 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 232
Query: 109 LRMGNYELISLLLRHGAN 126
+GN+EL+SLLL GA+
Sbjct: 233 AAVGNFELVSLLLERGAD 250
>gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens]
Length = 1104
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/138 (28%), Positives = 67/138 (48%), Gaps = 12/138 (8%)
Query: 1 MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 60
ML C ++ L+ + + + G++P+ A +++L+ AG D+N +
Sbjct: 576 MLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVV 635
Query: 61 QRINKHYDDHRKS----ALYFAVSNSDLSSVKLLLSAGALPNQDPVNC--------LQIA 108
+K+ H ++ AL FAV + + V+LLL AGA + LQ+A
Sbjct: 636 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 695
Query: 109 LRMGNYELISLLLRHGAN 126
+GN+EL+SLLL GA+
Sbjct: 696 AAVGNFELVSLLLERGAD 713
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 50.8 bits (120), Expect = 1e-06
Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 18/146 (12%)
Query: 21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 80
DL G++ +H AA G+HP C++LL++AG VN + + + S L++A
Sbjct: 217 DLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNL---------SCLHYAAL 267
Query: 81 NSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYF--CRVNP 135
+ ++L+ AG N + L +A+R L+ LL+ ++VN + P
Sbjct: 268 SGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTP 327
Query: 136 LHFPSALQYTLKDEVMLRMLLNYGYD 161
LH A ++ +D + MLL G D
Sbjct: 328 LHL--AAEHAWQD--IADMLLIAGVD 349
Score = 40.4 bits (93), Expect = 0.002
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 18/140 (12%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+ G + +H AA H L+ L+ G D+ + + +AL+ A S
Sbjct: 190 KEGNTALHLAAGRGHMAVLQRLVDIGLDL---------EEQNAEGLTALHSAAGGSHPDC 240
Query: 87 VKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHG--ANVNYFCRVNPLHFPSA 141
V+LLL AG+ N Q ++CL A G+ ++ +L+ G ANV +PLH A
Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL--A 298
Query: 142 LQYTLKDEVMLRMLLNYGYD 161
+++ ++R+L+N D
Sbjct: 299 VRHNF--PALVRLLINSDSD 316
Score = 32.3 bits (72), Expect = 0.53
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 9/74 (12%)
Query: 20 TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAV 79
+D+ A+ +P+H AA A ++L+ AG D+N D K+AL AV
Sbjct: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR---------DKQGKTALAVAV 365
Query: 80 SNSDLSSVKLLLSA 93
++ +S V +++ A
Sbjct: 366 RSNHVSLVDMIIKA 379
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A ++G+SP+H AA G H C+ LL+Q D I+ DH + L+ A
Sbjct: 331 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YDAEIDDITLDH-LTPLHVAAHC 381
Query: 82 SDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPL 136
K+LL GA PN +N L IA + + ++ LLL+ GA+++ + PL
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Query: 137 HFPS 140
H S
Sbjct: 442 HVAS 445
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)
Query: 25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 84
+ ++G +P+H AA + +LL+ G VNF I + L+ A ++
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPLHIASRRGNV 285
Query: 85 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 139
V+LLL GA +D + L A R G+ + +LL HGA + + ++P+H
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM- 344
Query: 140 SALQYTLKDEVMLRMLLNY 158
A Q D +R+LL Y
Sbjct: 345 -AAQGDHLD--CVRLLLQY 360
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 7 KFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINK 65
K +R +++L+ + A+ +SG++P+H A+ H ++ L+Q G N +
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKV 470
Query: 66 HYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGA 125
H + L K ++A A +Q P++C A R+G+ ++ LLL + A
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENNA 527
Query: 126 NVNYFCRV--NPLH 137
N N PLH
Sbjct: 528 NPNLATTAGHTPLH 541
Score = 39.7 bits (91), Expect = 0.003
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 13 LKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRK 72
L +L A + + G +P+H AA + ELL++ N +
Sbjct: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---------GKNGL 603
Query: 73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHG--ANV 127
+ L+ AV +++L VKLLL G P+ N L IA + E+ LL++G AN
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 128 NYFCRVNPLH 137
V PLH
Sbjct: 664 ESVQGVTPLH 673
Score = 37.7 bits (86), Expect = 0.013
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
++P+HCAA H + E+L+ G + + S ++ A L V+L
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL---------SPIHMAAQGDHLDCVRL 356
Query: 90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFPSALQY 144
LL A + D + L +A G++ + +LL GA N PLH +
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416
Query: 145 TLKDEVMLR 153
E++L+
Sbjct: 417 VRVMELLLK 425
Score = 35.4 bits (80), Expect = 0.062
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+SG++P+H A H ++LI+ G M+D Y + L+ A ++
Sbjct: 699 KSGLTPLHLVAQEGHVPVADVLIKHG----VMVDATTRMGY-----TPLHVASHYGNIKL 749
Query: 87 VKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 128
VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G++P+H AA H + + LL+ + N + + L+ +
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---------TPLHLVAQEGHVPVAD 718
Query: 89 LLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+L+ G + + L +A GN +L+ LL+H A+VN ++ +PLH
Sbjct: 719 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772
Score = 31.6 bits (70), Expect = 0.90
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 17 IPVTDLA--------AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 68
+PV D+ A + G +P+H A+ + + ++ L+Q DVN + Y
Sbjct: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN----AKTKLGY- 768
Query: 69 DHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLL 120
S L+ A V LLL GA PN+ D L IA R+G + +L
Sbjct: 769 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A ++G+SP+H AA G H C+ LL+Q D I+ DH + L+ A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YDAEIDDITLDH-LTPLHVAAHC 348
Query: 82 SDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPL 136
K+LL GA PN +N L IA + + ++ LLL+ GA+++ + PL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 137 HFPS 140
H S
Sbjct: 409 HVAS 412
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)
Query: 25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 84
+ ++G +P+H AA + +LL+ G VNF I + L+ A ++
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPLHIASRRGNV 252
Query: 85 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 139
V+LLL GA +D + L A R G+ + +LL HGA + + ++P+H
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM- 311
Query: 140 SALQYTLKDEVMLRMLLNY 158
A Q D +R+LL Y
Sbjct: 312 -AAQGDHLD--CVRLLLQY 327
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 7 KFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINK 65
K +R +++L+ + A+ +SG++P+H A+ H ++ L+Q G N +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKV 437
Query: 66 HYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGA 125
H + L K ++A A +Q P++C A R+G+ ++ LLL + A
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENNA 494
Query: 126 NVNYFCRV--NPLH 137
N N PLH
Sbjct: 495 NPNLATTAGHTPLH 508
Score = 39.7 bits (91), Expect = 0.003
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 13 LKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRK 72
L +L A + + G +P+H AA + ELL++ N +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---------GKNGL 570
Query: 73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHG--ANV 127
+ L+ AV +++L VKLLL G P+ N L IA + E+ LL++G AN
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 128 NYFCRVNPLH 137
V PLH
Sbjct: 631 ESVQGVTPLH 640
Score = 37.7 bits (86), Expect = 0.013
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
++P+HCAA H + E+L+ G + + S ++ A L V+L
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL---------SPIHMAAQGDHLDCVRL 323
Query: 90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFPSALQY 144
LL A + D + L +A G++ + +LL GA N PLH +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 145 TLKDEVMLR 153
E++L+
Sbjct: 384 VRVMELLLK 392
Score = 35.4 bits (80), Expect = 0.062
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+SG++P+H A H ++LI+ G M+D Y + L+ A ++
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHG----VMVDATTRMGY-----TPLHVASHYGNIKL 716
Query: 87 VKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 128
VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G++P+H AA H + + LL+ + N + + L+ +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---------TPLHLVAQEGHVPVAD 685
Query: 89 LLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+L+ G + + L +A GN +L+ LL+H A+VN ++ +PLH
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
Score = 31.6 bits (70), Expect = 0.90
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 17 IPVTDLA--------AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 68
+PV D+ A + G +P+H A+ + + ++ L+Q DVN + Y
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN----AKTKLGY- 735
Query: 69 DHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLL 120
S L+ A V LLL GA PN+ D L IA R+G + +L
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A ++G+SP+H AA G H C+ LL+Q D I+ DH + L+ A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YDAEIDDITLDH-LTPLHVAAHC 348
Query: 82 SDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPL 136
K+LL GA PN +N L IA + + ++ LLL+ GA+++ + PL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 137 HFPS 140
H S
Sbjct: 409 HVAS 412
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)
Query: 25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 84
+ ++G +P+H AA + +LL+ G VNF I + L+ A ++
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPLHIASRRGNV 252
Query: 85 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 139
V+LLL GA +D + L A R G+ + +LL HGA + + ++P+H
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM- 311
Query: 140 SALQYTLKDEVMLRMLLNY 158
A Q D +R+LL Y
Sbjct: 312 -AAQGDHLD--CVRLLLQY 327
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 7 KFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINK 65
K +R +++L+ + A+ +SG++P+H A+ H ++ L+Q G N +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKV 437
Query: 66 HYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGA 125
H + L K ++A A +Q P++C A R+G+ ++ LLL + A
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENNA 494
Query: 126 NVNYFCRV--NPLH 137
N N PLH
Sbjct: 495 NPNLATTAGHTPLH 508
Score = 39.7 bits (91), Expect = 0.003
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 13 LKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRK 72
L +L A + + G +P+H AA + ELL++ N +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---------GKNGL 570
Query: 73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHG--ANV 127
+ L+ AV +++L VKLLL G P+ N L IA + E+ LL++G AN
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 128 NYFCRVNPLH 137
V PLH
Sbjct: 631 ESVQGVTPLH 640
Score = 37.7 bits (86), Expect = 0.013
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
++P+HCAA H + E+L+ G + + S ++ A L V+L
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL---------SPIHMAAQGDHLDCVRL 323
Query: 90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFPSALQY 144
LL A + D + L +A G++ + +LL GA N PLH +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 145 TLKDEVMLR 153
E++L+
Sbjct: 384 VRVMELLLK 392
Score = 35.4 bits (80), Expect = 0.062
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+SG++P+H A H ++LI+ G M+D Y + L+ A ++
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHG----VMVDATTRMGY-----TPLHVASHYGNIKL 716
Query: 87 VKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 128
VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G++P+H AA H + + LL+ + N + + L+ +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---------TPLHLVAQEGHVPVAD 685
Query: 89 LLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+L+ G + + L +A GN +L+ LL+H A+VN ++ +PLH
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
Score = 31.6 bits (70), Expect = 0.90
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 17 IPVTDLA--------AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 68
+PV D+ A + G +P+H A+ + + ++ L+Q DVN + Y
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN----AKTKLGY- 735
Query: 69 DHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLL 120
S L+ A V LLL GA PN+ D L IA R+G + +L
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A ++G+SP+H AA G H C+ LL+Q D I+ DH + L+ A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YDAEIDDITLDH-LTPLHVAAHC 348
Query: 82 SDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPL 136
K+LL GA PN +N L IA + + ++ LLL+ GA+++ + PL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 137 HFPS 140
H S
Sbjct: 409 HVAS 412
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)
Query: 25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 84
+ ++G +P+H AA + +LL+ G VNF I + L+ A ++
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPLHIASRRGNV 252
Query: 85 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 139
V+LLL GA +D + L A R G+ + +LL HGA + + ++P+H
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM- 311
Query: 140 SALQYTLKDEVMLRMLLNY 158
A Q D +R+LL Y
Sbjct: 312 -AAQGDHLD--CVRLLLQY 327
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 7 KFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINK 65
K +R +++L+ + A+ +SG++P+H A+ H ++ L+Q G N +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKV 437
Query: 66 HYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGA 125
H + L K ++A A +Q P++C A R+G+ ++ LLL + A
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENNA 494
Query: 126 NVNYFCRV--NPLH 137
N N PLH
Sbjct: 495 NPNLATTAGHTPLH 508
Score = 39.7 bits (91), Expect = 0.003
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 13 LKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRK 72
L +L A + + G +P+H AA + ELL++ N +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---------GKNGL 570
Query: 73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHG--ANV 127
+ L+ AV +++L VKLLL G P+ N L IA + E+ LL++G AN
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 128 NYFCRVNPLH 137
V PLH
Sbjct: 631 ESVQGVTPLH 640
Score = 37.7 bits (86), Expect = 0.013
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
++P+HCAA H + E+L+ G + + S ++ A L V+L
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL---------SPIHMAAQGDHLDCVRL 323
Query: 90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFPSALQY 144
LL A + D + L +A G++ + +LL GA N PLH +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 145 TLKDEVMLR 153
E++L+
Sbjct: 384 VRVMELLLK 392
Score = 35.4 bits (80), Expect = 0.062
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+SG++P+H A H ++LI+ G M+D Y + L+ A ++
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHG----VMVDATTRMGY-----TPLHVASHYGNIKL 716
Query: 87 VKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 128
VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G++P+H AA H + + LL+ + N + + L+ +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---------TPLHLVAQEGHVPVAD 685
Query: 89 LLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+L+ G + + L +A GN +L+ LL+H A+VN ++ +PLH
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
Score = 31.6 bits (70), Expect = 0.90
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 17 IPVTDLA--------AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 68
+PV D+ A + G +P+H A+ + + ++ L+Q DVN + Y
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN----AKTKLGY- 735
Query: 69 DHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLL 120
S L+ A V LLL GA PN+ D L IA R+G + +L
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A ++G+SP+H AA G H C+ LL+Q D I+ DH + L+ A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YDAEIDDITLDH-LTPLHVAAHC 348
Query: 82 SDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPL 136
K+LL GA PN +N L IA + + ++ LLL+ GA+++ + PL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 137 HFPS 140
H S
Sbjct: 409 HVAS 412
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)
Query: 25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 84
+ ++G +P+H AA + +LL+ G VNF I + L+ A ++
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPLHIASRRGNV 252
Query: 85 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 139
V+LLL GA +D + L A R G+ + +LL HGA + + ++P+H
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM- 311
Query: 140 SALQYTLKDEVMLRMLLNY 158
A Q D +R+LL Y
Sbjct: 312 -AAQGDHLD--CVRLLLQY 327
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 7 KFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINK 65
K +R +++L+ + A+ +SG++P+H A+ H ++ L+Q G N +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKV 437
Query: 66 HYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGA 125
H + L K ++A A +Q P++C A R+G+ ++ LLL + A
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENNA 494
Query: 126 NVNYFCRV--NPLH 137
N N PLH
Sbjct: 495 NPNLATTAGHTPLH 508
Score = 39.7 bits (91), Expect = 0.003
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 13 LKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRK 72
L +L A + + G +P+H AA + ELL++ N +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---------GKNGL 570
Query: 73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHG--ANV 127
+ L+ AV +++L VKLLL G P+ N L IA + E+ LL++G AN
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 128 NYFCRVNPLH 137
V PLH
Sbjct: 631 ESVQGVTPLH 640
Score = 37.7 bits (86), Expect = 0.013
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
++P+HCAA H + E+L+ G + + S ++ A L V+L
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL---------SPIHMAAQGDHLDCVRL 323
Query: 90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFPSALQY 144
LL A + D + L +A G++ + +LL GA N PLH +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 145 TLKDEVMLR 153
E++L+
Sbjct: 384 VRVMELLLK 392
Score = 35.4 bits (80), Expect = 0.062
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+SG++P+H A H ++LI+ G M+D Y + L+ A ++
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHG----VMVDATTRMGY-----TPLHVASHYGNIKL 716
Query: 87 VKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 128
VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
G++P+H AA H + + LL+ + N + + L+ +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---------TPLHLVAQEGHVPVAD 685
Query: 89 LLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+L+ G + + L +A GN +L+ LL+H A+VN ++ +PLH
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
Score = 31.6 bits (70), Expect = 0.90
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 17 IPVTDLA--------AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 68
+PV D+ A + G +P+H A+ + + ++ L+Q DVN + Y
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN----AKTKLGY- 735
Query: 69 DHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLL 120
S L+ A V LLL GA PN+ D L IA R+G + +L
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 49.3 bits (116), Expect = 4e-06
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 14/116 (12%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
++G+SP+H A G H C++LL+Q V+ + + + +AL+ A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL---------TALHVAAHCGHYKV 382
Query: 87 VKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNYFCR--VNPLH 137
K+LL A PN +N L IA + +++ LLL+HGA++ + P+H
Sbjct: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Score = 41.2 bits (95), Expect = 0.001
Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 14/106 (13%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+ G++P+HC A H Q +E+L+ + ++K + S L+ A L+
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPI-------LSK--TKNGLSPLHMATQGDHLNC 349
Query: 87 VKLLLSAGALPNQDPVN----CLQIALRMGNYELISLLLRHGANVN 128
V+LLL +P D N L +A G+Y++ +LL AN N
Sbjct: 350 VQLLLQHN-VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/110 (25%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 22 LAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSN 81
+ A+ +SG++P+H AA H + L+ G N + ++AL+ A +
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT---------NVRGETALHMAARS 476
Query: 82 SDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 128
V+ L+ GA +D L I+ R+G +++ LL+ GA+ N
Sbjct: 477 GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Score = 39.3 bits (90), Expect = 0.004
Identities = 33/138 (23%), Positives = 60/138 (43%), Gaps = 14/138 (10%)
Query: 21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 80
D A+ + GI+ VH AA H + LL+ +VN + + L+ A
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL---------TPLHLAAQ 706
Query: 81 NSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNP 135
++ ++L++ GA + L + GN ++++ LL+H A VN + P
Sbjct: 707 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766
Query: 136 LHFPSALQYTLKDEVMLR 153
LH + +T V+L+
Sbjct: 767 LHQAAQQGHTHIINVLLQ 784
Score = 38.9 bits (89), Expect = 0.006
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 12/103 (11%)
Query: 24 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD 83
A + G + +H A+ + +++L+ G +VN + LY A +
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF---------TPLYMAAQENH 152
Query: 84 LSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRH 123
L VK LL GA L +D L +AL+ G+ +++SLLL +
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 35.4 bits (80), Expect = 0.062
Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 16/120 (13%)
Query: 24 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKH-YDDHRKSALYFAVSNS 82
A +SG++P+H AA + + LL LDQ + H + + L+ A +
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLL----------LDQGASPHAAAKNGYTPLHIAAKKN 642
Query: 83 DLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLH 137
+ LL GA N + + + +A + G+ +++SLLL ANVN + + PLH
Sbjct: 643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702
Score = 34.3 bits (77), Expect = 0.14
Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 14/119 (11%)
Query: 24 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD 83
A ++G +P+H AA L++ G D N + Q I ++++ A
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI---------ASVHLAAQEGH 676
Query: 84 LSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRV--NPLH 137
+ V LLL A L N+ + L +A + + +L+ GA+V+ ++ PLH
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735
Score = 30.0 bits (66), Expect = 2.6
Identities = 31/136 (22%), Positives = 55/136 (40%), Gaps = 25/136 (18%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ-RINKHYDDHRKSAL---------- 75
+ G +P+ A H Q + LL++ L I DD + +AL
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV 230
Query: 76 ---------YFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRH 123
+ A +++ LLL+ A + ++ + L +A + GN ++ LLL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Query: 124 GANVNYFCR--VNPLH 137
GA ++ R + PLH
Sbjct: 291 GAKIDAKTRDGLTPLH 306
Score = 28.9 bits (63), Expect = 5.8
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 98 NQDPVNCLQIALRMGNYELISLLLRHGANVN 128
NQ+ +N L +A + G+ E++S LL+ ANV+
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVD 101
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 48.9 bits (115), Expect = 5e-06
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 12/111 (10%)
Query: 19 VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 78
VTDL A G +P+ AA A + LI DVN + DDH KSAL++A
Sbjct: 1934 VTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAV---------DDHGKSALHWA 1984
Query: 79 VSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGAN 126
+ +++ + LLL GA + + L +A R G+YE +LL H AN
Sbjct: 1985 AAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN 2035
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 48.5 bits (114), Expect = 7e-06
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 12/103 (11%)
Query: 24 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD 83
A ++G +P+ AAA H +C+ELLI ++N H D ++ LY A N +
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANIN---------HAADGGQTPLYLACKNGN 822
Query: 84 LSSVKLLLSAG---ALPNQDPVNCLQIALRMGNYELISLLLRH 123
+KLLL AG ++ D + A+ GN + + LL+ H
Sbjct: 823 KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH 865
Score = 43.5 bits (101), Expect = 2e-04
Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 13/98 (13%)
Query: 36 AAAGAHPQCLELLI-QAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAG 94
AAA + L +L+ + G D+N+ + D H SALY A N V+LLLSA
Sbjct: 717 AAAQGNVTLLSMLLNEEGLDINYSCE-------DGH--SALYSAAKNGHTDCVRLLLSAE 767
Query: 95 ALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNY 129
A N N L A G++E + LL+ + AN+N+
Sbjct: 768 AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH 805
Score = 36.6 bits (83), Expect = 0.028
Identities = 33/106 (31%), Positives = 45/106 (42%), Gaps = 18/106 (16%)
Query: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
+ G S ++ AA H C+ LL+ A VN D + + L A +
Sbjct: 742 EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA---------DKNGFTPLCAAAAQGHFEC 792
Query: 87 VKLLLSAGALPN------QDPVNCLQIALRMGNYELISLLLRHGAN 126
V+LL+S A N Q P L +A + GN E I LLL G N
Sbjct: 793 VELLISYDANINHAADGGQTP---LYLACKNGNKECIKLLLEAGTN 835
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 47.8 bits (112), Expect = 1e-05
Identities = 37/137 (27%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 89
+SP+H A G H C+++L++ G VN + D H + L+ A + V L
Sbjct: 70 VSPLHEACLGGHLSCVKILLKHGAQVNGVT-------ADWH--TPLFNACVSGSWDCVNL 120
Query: 90 LLSAGA--LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLK 147
LL GA P D + + A R G+ E ++ L+ +G N+++ +++ L P L +
Sbjct: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDH--KISHLGTPLYLACENQ 178
Query: 148 DEVMLRMLLNYGYDTER 164
++ LL G D +
Sbjct: 179 QRACVKKLLESGADVNQ 195
>gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [Homo
sapiens]
Length = 309
Score = 47.4 bits (111), Expect = 2e-05
Identities = 34/101 (33%), Positives = 51/101 (50%), Gaps = 12/101 (11%)
Query: 31 SPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL 90
+P+ AA+ H CL++L+ G DV+ + D ++ L+ AVS+ L V++L
Sbjct: 66 TPLRLAASYGHLSCLQVLLAHGADVDSL---------DVKAQTPLFTAVSHGHLDCVRVL 116
Query: 91 LSAGALPNQDPV-NCLQI--ALRMGNYELISLLLRHGANVN 128
L AGA P NC + A R G ++ LL HGA N
Sbjct: 117 LEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEAN 157
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 46.6 bits (109), Expect = 3e-05
Identities = 39/110 (35%), Positives = 55/110 (50%), Gaps = 12/110 (10%)
Query: 20 TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAV 79
TDL A G +P+ AA A LE LI + DVN + DD KSAL++A
Sbjct: 1986 TDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAV---------DDLGKSALHWAA 2036
Query: 80 SNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGAN 126
+ +++ + +LL GA + N L +A R G+YE +LL H AN
Sbjct: 2037 AVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFAN 2086
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 46.6 bits (109), Expect = 3e-05
Identities = 39/139 (28%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 26 KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLS 85
+QS +P+H AA + +L+QAG ++N + D +++ L AV N+ L
Sbjct: 648 QQSKRTPLHAAAQKGSVEICHVLLQAGANINAV---------DKQQRTPLMEAVVNNHLE 698
Query: 86 SVKLLLSAGAL---PNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSAL 142
+ ++ G +D CL A ++GN E++SLLL G V+ + + P
Sbjct: 699 VARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTG-QVDVNAQDSGGWTPIIW 757
Query: 143 QYTLKDEVMLRMLLNYGYD 161
K ++RMLL G D
Sbjct: 758 AAEHKHIEVIRMLLTRGAD 776
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.141 0.447
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,337,103
Number of Sequences: 37866
Number of extensions: 479350
Number of successful extensions: 2329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 1391
Number of HSP's gapped (non-prelim): 771
length of query: 302
length of database: 18,247,518
effective HSP length: 102
effective length of query: 200
effective length of database: 14,385,186
effective search space: 2877037200
effective search space used: 2877037200
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.