Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 182765466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 1479 0.0
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens] 447 e-125
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 89 1e-17
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 89 1e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 84 5e-16
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 83 1e-15
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] 81 4e-15
gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] 81 4e-15
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens] 80 5e-15
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 80 7e-15
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 80 7e-15
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 79 2e-14
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 75 2e-13
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 72 1e-12
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 72 1e-12
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 72 1e-12
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 72 2e-12
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 72 2e-12
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 72 2e-12
gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens] 70 9e-12
gi|239745060 PREDICTED: similar to breast cancer anti-estrogen r... 69 1e-11
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 68 3e-11
gi|11321634 CD2-associated protein [Homo sapiens] 67 6e-11
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 66 1e-10
gi|239756225 PREDICTED: similar to breast cancer anti-estrogen r... 65 2e-10
gi|239750776 PREDICTED: similar to breast cancer anti-estrogen r... 65 2e-10
gi|239745044 PREDICTED: similar to breast cancer anti-estrogen r... 65 2e-10
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 60 6e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 60 6e-09
gi|148747351 protein kinase C and casein kinase substrate in neu... 58 3e-08
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 1479 bits (3830), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL 60
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL
Sbjct: 1 MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL 60
Query: 61 ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR 120
ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR
Sbjct: 61 ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR 120
Query: 121 SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF 180
SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
Sbjct: 121 SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF 180
Query: 181 QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN 240
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN
Sbjct: 181 QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN 240
Query: 241 VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ 300
VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ
Sbjct: 241 VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ 300
Query: 301 FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS 360
FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
Sbjct: 301 FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS 360
Query: 361 EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE 420
EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE
Sbjct: 361 EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE 420
Query: 421 RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY 480
RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY
Sbjct: 421 RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY 480
Query: 481 KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL 540
KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL
Sbjct: 481 KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL 540
Query: 541 AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE 600
AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE
Sbjct: 541 AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE 600
Query: 601 NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD 660
NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD
Sbjct: 601 NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD 660
Query: 661 QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP 720
QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP
Sbjct: 661 QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP 720
Query: 721 PTQNHRRPAEKIEDVEITLV 740
PTQNHRRPAEKIEDVEITLV
Sbjct: 721 PTQNHRRPAEKIEDVEITLV 740
>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
Length = 690
Score = 447 bits (1149), Expect = e-125
Identities = 283/732 (38%), Positives = 414/732 (56%), Gaps = 62/732 (8%)
Query: 1 MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL 60
MQPPPRKVK QE+K +EQ++ LQ Q E DLLED+R++S+++AAIEREY Q +QKL
Sbjct: 1 MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL 60
Query: 61 ASQYLKRDWPGVKADDRNDY-RSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTV 119
A +LKR+ G ++ + + R+++ W+ L+ T+ Q+R+ + Y++ T
Sbjct: 61 AGPFLKRE--GHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGG---TG 115
Query: 120 RSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKA-DIEAKSKLS 178
RS KEQ L++ + L + Q E+ ++V++L++ +K Y + E++ +EKA D++A+ S
Sbjct: 116 RSAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRS 175
Query: 179 ---LFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMK 235
+F SR SLQK S KL A+ ++ + + ARN+YLL L A NAH D YYQ +L ++K
Sbjct: 176 DHGIFHSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLK 235
Query: 236 ALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHK 295
AL + +HL+D L + S TELE + + + +S+V + +L+LFLQE VF
Sbjct: 236 ALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSP 295
Query: 296 PQPFQFQPCDSDTSRQLE-SETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLEC 354
P QFQP +D LE G + L KE ++ +R AR++K H RVL LE
Sbjct: 296 TPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQ 355
Query: 355 HGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVM 414
SE+ +EQ++ E RE+IR+A++ ++K ARL LL+ G+ V+ WLK AM Q
Sbjct: 356 RRQQASEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQ 415
Query: 415 EELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTC 474
+E+E ER A S L D E + EE E+ ++F++ + T R P
Sbjct: 416 DEVEQER-RLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALAT-RALPCPA 473
Query: 475 KVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLL 534
VV+ Y+A + DELTI E E LEVIE+GD ++WVKARN+ G+VG+VPE+YL FP
Sbjct: 474 HVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPD----- 528
Query: 535 SMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAII 594
+L S S N AE + +ALY Y GQ+ +ELSFPEGA+I
Sbjct: 529 ------LSLPESSQDSDNPCGAE---------PTAFLAQALYSYTGQSAEELSFPEGALI 573
Query: 595 RILNK-ENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASL 653
R+L + ++ DDGFW GEF GR+GVFPS+LVEEL G Q+ PSP P +
Sbjct: 574 RLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEEL-LGPPGPPELSDPEQMLPSPSPPSFS 632
Query: 654 PPLP--LYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKL 711
PP P + D PP+ P +K+L + PGF + +L
Sbjct: 633 PPAPTSVLDGPPAPVLP----------------GDKAL--DFPGFL-------DMMAPRL 667
Query: 712 RPVRAAPPPPTQ 723
RP+R PPPP +
Sbjct: 668 RPMRPPPPPPAK 679
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 89.0 bits (219), Expect = 1e-17
Identities = 92/344 (26%), Positives = 148/344 (43%), Gaps = 52/344 (15%)
Query: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
+E++ EQM L + + LL+D++ F +KKA IE +Y++ ++KLA ++L +
Sbjct: 22 KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
Query: 72 VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121
+ D + PV W L + ++ + + Y N I + R +
Sbjct: 82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKK 141
Query: 122 LKE--QQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETE-----QMAHAVRE 167
KE QQL+ D L K+ EL +K D + K E E Q+ +V++
Sbjct: 142 SKEVGQQLQ---DDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQ 198
Query: 168 K-----------ADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLA 216
+ A++ + K S ++K K +A+ +E KA ARN+YLL L
Sbjct: 199 EDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALE 258
Query: 217 AANAHQDRYYQTDLVNIM-KALDGNVYDHLKDYLIAFSRTEL-------ETCQAVQNTFQ 268
A NA +YY DL +++ + D + L L F EL E A++N +
Sbjct: 259 ATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVE 318
Query: 269 FLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQL 312
L S K +L N VF P F+FQP D + QL
Sbjct: 319 NLDATSDK------QRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
Score = 38.5 bits (88), Expect = 0.023
Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 3/47 (6%)
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620
A +DY G+T ELSF +GA + + + + D +WEG NG G+ P
Sbjct: 735 AKFDYVGRTARELSFKKGASLLLYQRASDD---WWEGRHNGIDGLIP 778
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 89.0 bits (219), Expect = 1e-17
Identities = 92/344 (26%), Positives = 148/344 (43%), Gaps = 52/344 (15%)
Query: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
+E++ EQM L + + LL+D++ F +KKA IE +Y++ ++KLA ++L +
Sbjct: 22 KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
Query: 72 VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121
+ D + PV W L + ++ + + Y N I + R +
Sbjct: 82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKK 141
Query: 122 LKE--QQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETE-----QMAHAVRE 167
KE QQL+ D L K+ EL +K D + K E E Q+ +V++
Sbjct: 142 SKEVGQQLQ---DDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQ 198
Query: 168 K-----------ADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLA 216
+ A++ + K S ++K K +A+ +E KA ARN+YLL L
Sbjct: 199 EDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALE 258
Query: 217 AANAHQDRYYQTDLVNIM-KALDGNVYDHLKDYLIAFSRTEL-------ETCQAVQNTFQ 268
A NA +YY DL +++ + D + L L F EL E A++N +
Sbjct: 259 ATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVE 318
Query: 269 FLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQL 312
L S K +L N VF P F+FQP D + QL
Sbjct: 319 NLDATSDK------QRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
Score = 38.5 bits (88), Expect = 0.023
Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 3/47 (6%)
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620
A +DY G+T ELSF +GA + + + + D +WEG NG G+ P
Sbjct: 735 AKFDYVGRTARELSFKKGASLLLYQRASDD---WWEGRHNGIDGLIP 778
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 84.0 bits (206), Expect = 5e-16
Identities = 59/187 (31%), Positives = 99/187 (52%), Gaps = 27/187 (14%)
Query: 460 SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIED---GDMEDWVKARNKVGQ 516
++ +G+L P +V+ SY A+ P++LT+ +++ + + G E ++AR K Q
Sbjct: 1065 TAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQ 1124
Query: 517 VGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALY 576
+G+ P Y++ LLS TS + S +L A+VC V +Y
Sbjct: 1125 IGWFPANYVK------LLS-----------PGTSKITPTEPPKSTAL---AAVCQVIGMY 1164
Query: 577 DYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTP 636
DY Q DDEL+F +G II +LNKE+ D +W+GE NG++G+FPS V +L+ +
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPD---WWKGEVNGQVGLFPSNYV-KLTTDMDPSQQ 1220
Query: 637 WMREIQI 643
W ++ +
Sbjct: 1221 WCSDLHL 1227
Score = 57.4 bits (137), Expect = 5e-08
Identities = 61/238 (25%), Positives = 102/238 (42%), Gaps = 34/238 (14%)
Query: 404 TWLKSAMNQVMEELENERWARPPAVT--SNGTLHSLNADTEREEGEEFEDNMDVFDDSSS 461
TW S N+ E + WA P++T S G L +A T + S
Sbjct: 856 TWPTST-NEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATA-------------TGS 901
Query: 462 SPSGTL----RNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQV 517
SPS L + L + +Y ++A + + L +++V+ V+E DM + + + GQ
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQ---GQK 958
Query: 518 GYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYD 577
G+ P+ Y++ + S S+ + S S S + ++G+ + A+Y
Sbjct: 959 GWFPKSYVKLISGPIRKST--SMDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYT 1012
Query: 578 YEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDT 635
YE +L+F +G +I + K D +W G + GVFPS V L SE T
Sbjct: 1013 YESSEQGDLTFQQGDVILVTKK----DGDWWTGTVGDKAGVFPSNYV-RLKDSEGSGT 1065
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 20/167 (11%)
Query: 562 SLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRI----LNKENQDDDGFWEGEFNGRIG 617
S + V + +ALY +E ++ DE++ G I+ + +++ + G+ GE G+ G
Sbjct: 735 SAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTG 794
Query: 618 VFPSVLVEELSASE-NGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSL 676
FP+ E++ +E + + +P+PK P PL S P +P+ +
Sbjct: 795 WFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPL-AVTSSEPSTTPNNWADF 853
Query: 677 YFPRSPSANEK-------------SLHAESPG-FSQASRHTPETSYG 709
S NEK SL S G Q S TP T+ G
Sbjct: 854 SSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 82.8 bits (203), Expect = 1e-15
Identities = 57/169 (33%), Positives = 92/169 (54%), Gaps = 26/169 (15%)
Query: 460 SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIED---GDMEDWVKARNKVGQ 516
++ +G+L P +V+ SY A+ P++LT+ +++ + + G E ++AR K Q
Sbjct: 1065 TAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQ 1124
Query: 517 VGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALY 576
+G+ P Y++ LLS TS + S +L A+VC V +Y
Sbjct: 1125 IGWFPANYVK------LLS-----------PGTSKITPTEPPKSTAL---AAVCQVIGMY 1164
Query: 577 DYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVE 625
DY Q DDEL+F +G II +LNKE+ D +W+GE NG++G+FPS V+
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPD---WWKGEVNGQVGLFPSNYVK 1210
Score = 57.4 bits (137), Expect = 5e-08
Identities = 61/238 (25%), Positives = 102/238 (42%), Gaps = 34/238 (14%)
Query: 404 TWLKSAMNQVMEELENERWARPPAVT--SNGTLHSLNADTEREEGEEFEDNMDVFDDSSS 461
TW S N+ E + WA P++T S G L +A T + S
Sbjct: 856 TWPTST-NEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATA-------------TGS 901
Query: 462 SPSGTL----RNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQV 517
SPS L + L + +Y ++A + + L +++V+ V+E DM + + + GQ
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQ---GQK 958
Query: 518 GYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYD 577
G+ P+ Y++ + S S+ + S S S + ++G+ + A+Y
Sbjct: 959 GWFPKSYVKLISGPIRKST--SMDSGSSESPASLKRVASPAAKPVVSGEEFI----AMYT 1012
Query: 578 YEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDT 635
YE +L+F +G +I + K D +W G + GVFPS V L SE T
Sbjct: 1013 YESSEQGDLTFQQGDVILVTKK----DGDWWTGTVGDKAGVFPSNYV-RLKDSEGSGT 1065
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 20/167 (11%)
Query: 562 SLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRI----LNKENQDDDGFWEGEFNGRIG 617
S + V + +ALY +E ++ DE++ G I+ + +++ + G+ GE G+ G
Sbjct: 735 SAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTG 794
Query: 618 VFPSVLVEELSASE-NGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSL 676
FP+ E++ +E + + +P+PK P PL S P +P+ +
Sbjct: 795 WFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPL-AVTSSEPSTTPNNWADF 853
Query: 677 YFPRSPSANEK-------------SLHAESPG-FSQASRHTPETSYG 709
S NEK SL S G Q S TP T+ G
Sbjct: 854 SSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 474 CKVV--YSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPT 529
C+V+ Y Y A DEL + +++ V+ D + W N GQVG P Y++ T
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN--GQVGLFPSNYVKLTT 1213
>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
Length = 551
Score = 80.9 bits (198), Expect = 4e-15
Identities = 121/548 (22%), Positives = 206/548 (37%), Gaps = 62/548 (11%)
Query: 20 EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79
+Q L Q D LE F +++ IE+ YA+ ++ L +Y P + D
Sbjct: 9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYC----PKRSSKDEEP 64
Query: 80 YRSMYPVWKSFLEGTMQVAQSRMNICENYKNFI-SEPARTVRSLKEQQLKRCVDQLTKIQ 138
+ + + L A R + E + + E R LK ++ K + + K Q
Sbjct: 65 RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTER-KMHLQEGRKAQ 123
Query: 139 TELQETVKDLAKGKKKYFETE----QMAHAVREKADIEAKSKLSLFQSRISLQKASVKLK 194
L K + KKK FE E + A E+ D + + ++ ++KA +L
Sbjct: 124 QYLDMCWKQMDNSKKK-FERECREAEKAQQSYERLDNDTNA------TKADVEKAKQQLN 176
Query: 195 ARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKAL---DGNVYDHLKDYLIA 251
R A +N+Y L N Q +++ + I K L D L +
Sbjct: 177 LR----THMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRG 232
Query: 252 FSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQE-NAVFHKPQPFQFQPCDSDTSR 310
F+ +E + + + ++ + V + Q+ + + F P F F+ R
Sbjct: 233 FADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYR 292
Query: 311 QLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQK 370
+ T + + K K A+ + ++ LE EQ R +L+Q+
Sbjct: 293 TISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQR 352
Query: 371 IDEARENIRKAEIIKLKAEARLDLLK---QIGV--SVDTWLKSAMNQV----MEELENER 421
IDE ++K K D+ + Q+G S+ L MN + ME +NE
Sbjct: 353 IDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEA 412
Query: 422 W---------ARPPAVTSNGTLHSLNADTEREEGEEFED-NMDV------------FDDS 459
W R S+ H + E EG +D N +V FDD
Sbjct: 413 WLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDE 472
Query: 460 --SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQV 517
P + + CK +Y + L ++E EVL +IE+ + W +AR + G+
Sbjct: 473 FEDDDPLPAIGH----CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEE 528
Query: 518 GYVPEKYL 525
GYVP Y+
Sbjct: 529 GYVPTSYI 536
>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
Length = 547
Score = 80.9 bits (198), Expect = 4e-15
Identities = 121/548 (22%), Positives = 206/548 (37%), Gaps = 62/548 (11%)
Query: 20 EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79
+Q L Q D LE F +++ IE+ YA+ ++ L +Y P + D
Sbjct: 9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYC----PKRSSKDEEP 64
Query: 80 YRSMYPVWKSFLEGTMQVAQSRMNICENYKNFI-SEPARTVRSLKEQQLKRCVDQLTKIQ 138
+ + + L A R + E + + E R LK ++ K + + K Q
Sbjct: 65 RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTER-KMHLQEGRKAQ 123
Query: 139 TELQETVKDLAKGKKKYFETE----QMAHAVREKADIEAKSKLSLFQSRISLQKASVKLK 194
L K + KKK FE E + A E+ D + + ++ ++KA +L
Sbjct: 124 QYLDMCWKQMDNSKKK-FERECREAEKAQQSYERLDNDTNA------TKADVEKAKQQLN 176
Query: 195 ARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKAL---DGNVYDHLKDYLIA 251
R A +N+Y L N Q +++ + I K L D L +
Sbjct: 177 LR----THMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRG 232
Query: 252 FSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQE-NAVFHKPQPFQFQPCDSDTSR 310
F+ +E + + + ++ + V + Q+ + + F P F F+ R
Sbjct: 233 FADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYR 292
Query: 311 QLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQK 370
+ T + + K K A+ + ++ LE EQ R +L+Q+
Sbjct: 293 TISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQR 352
Query: 371 IDEARENIRKAEIIKLKAEARLDLLK---QIGV--SVDTWLKSAMNQV----MEELENER 421
IDE ++K K D+ + Q+G S+ L MN + ME +NE
Sbjct: 353 IDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEA 412
Query: 422 W---------ARPPAVTSNGTLHSLNADTEREEGEEFED-NMDV------------FDDS 459
W R S+ H + E EG +D N +V FDD
Sbjct: 413 WLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDE 472
Query: 460 --SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQV 517
P + + CK +Y + L ++E EVL +IE+ + W +AR + G+
Sbjct: 473 FEDDDPLPAIGH----CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEE 528
Query: 518 GYVPEKYL 525
GYVP Y+
Sbjct: 529 GYVPTSYI 536
>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
Length = 545
Score = 80.5 bits (197), Expect = 5e-15
Identities = 118/564 (20%), Positives = 223/564 (39%), Gaps = 88/564 (15%)
Query: 20 EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79
+Q L+ Q DLL+ F +++ +E+ YA+ ++ L +YL K ++D
Sbjct: 9 DQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLP------KRPAKDD 62
Query: 80 YRSMYPVWKSFLEGTMQV---AQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTK 136
S + +SF++ +V A R + EN + +Q+ K + +
Sbjct: 63 PESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRR 122
Query: 137 IQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKAR 196
Q +L+ K L K+K+ + A + A+ I+ KA V+ +
Sbjct: 123 AQQQLENGFKQLENSKRKFERDCREAEKAAQTAE--------RLDQDINATKADVEKAKQ 174
Query: 197 RSECNSK-ATHARNDYLLTLAAANAHQDRYYQTDLVNI---MKALDGNVYDHLKDYLIAF 252
++ S A ++N+Y L N Q +Y + + I ++ +D L
Sbjct: 175 QAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLL 234
Query: 253 SRTELETCQAVQNTFQFL--LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSR 310
S ELE + + + N+ D ++ + L ++ F +P +F+ +R
Sbjct: 235 SEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSG-FARPGDVEFEDFSQPMNR 293
Query: 311 Q-LESETGTTEEH--SLNKEARKWATR--VAREHKNIV-----------HQQRVLNDLEC 354
+S GT + L R R +++K +V ++R+ LE
Sbjct: 294 APSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLE- 352
Query: 355 HGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAE----------------ARLDLLKQI 398
E+SR EL++++D+ RE ++K + + K + ++ LK
Sbjct: 353 ------ERSR-ELQKEVDQ-REALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLE 404
Query: 399 GVSVDTWLKSAMNQVMEELENE--RWARPPAV--------TSNGTLHSLNADTEREEGEE 448
+ WL A ++V+ + R ARPP +SN +E EE
Sbjct: 405 VQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEE 464
Query: 449 FEDNM------DVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDG 502
+D + F++ +SP G C +Y ++ S +++ E E L ++E+
Sbjct: 465 SQDTPIYTEFDEDFEEEPTSPIGH-------CVAIYHFEGSSEGTISMAEGEDLSLMEED 517
Query: 503 DMEDWVKARNKVGQVGYVPEKYLQ 526
+ W + R K G GYVP YL+
Sbjct: 518 KGDGWTRVRRKEGGEGYVPTSYLR 541
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 80.1 bits (196), Expect = 7e-15
Identities = 84/335 (25%), Positives = 144/335 (42%), Gaps = 39/335 (11%)
Query: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
+E++ VEQ L+ + ++ LL+D++ F ++KA IE EY++ ++KLA ++ +
Sbjct: 22 KEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS 81
Query: 72 VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121
+ + D + PV W L T + ++ + + + N + + R +
Sbjct: 82 REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKK 141
Query: 122 LKEQQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETEQMAHAVREKAD---- 170
KE L+ ++L K+ EL +K + + K E E+ K+
Sbjct: 142 SKEIGLQMH-EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSM 200
Query: 171 --IEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQT 228
+ + + S ++K K +A+ SE K T ARNDYLL LAA NA +YY
Sbjct: 201 NLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIH 260
Query: 229 DLVNIMKALDGNVYDHL----KDYLIAFSRTEL---ETCQAVQNTFQFLLENSSK-VVRD 280
D+ +++ D + L + YL A E E ++N L S K V D
Sbjct: 261 DVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMD 320
Query: 281 YNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESE 315
N VF P F+FQP D Q+ ++
Sbjct: 321 -------MCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 5/76 (6%)
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPS--VLVEELSASE 631
A +DY G++ ELSF +GA + + ++ ++D +WEG NG G+ P ++V+++ +
Sbjct: 727 AKFDYMGRSPRELSFKKGASLLLYHRASED---WWEGRHNGVDGLIPHQYIVVQDMDDAF 783
Query: 632 NGDTPWMREIQISPSP 647
+ + + S P
Sbjct: 784 SDSLSQKADSEASSGP 799
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 80.1 bits (196), Expect = 7e-15
Identities = 84/335 (25%), Positives = 144/335 (42%), Gaps = 39/335 (11%)
Query: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
+E++ VEQ L+ + ++ LL+D++ F ++KA IE EY++ ++KLA ++ +
Sbjct: 22 KEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS 81
Query: 72 VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121
+ + D + PV W L T + ++ + + + N + + R +
Sbjct: 82 REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKK 141
Query: 122 LKEQQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETEQMAHAVREKAD---- 170
KE L+ ++L K+ EL +K + + K E E+ K+
Sbjct: 142 SKEIGLQMH-EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSM 200
Query: 171 --IEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQT 228
+ + + S ++K K +A+ SE K T ARNDYLL LAA NA +YY
Sbjct: 201 NLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIH 260
Query: 229 DLVNIMKALDGNVYDHL----KDYLIAFSRTEL---ETCQAVQNTFQFLLENSSK-VVRD 280
D+ +++ D + L + YL A E E ++N L S K V D
Sbjct: 261 DVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMD 320
Query: 281 YNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESE 315
N VF P F+FQP D Q+ ++
Sbjct: 321 -------MCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 5/76 (6%)
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPS--VLVEELSASE 631
A +DY G++ ELSF +GA + + ++ ++D +WEG NG G+ P ++V+++ +
Sbjct: 751 AKFDYMGRSPRELSFKKGASLLLYHRASED---WWEGRHNGVDGLIPHQYIVVQDMDDAF 807
Query: 632 NGDTPWMREIQISPSP 647
+ + + S P
Sbjct: 808 SDSLSQKADSEASSGP 823
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 78.6 bits (192), Expect = 2e-14
Identities = 80/333 (24%), Positives = 145/333 (43%), Gaps = 36/333 (10%)
Query: 20 EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79
EQ+ L+ + + +LL+++ F +++A +E EY++G++KLA ++ R + +
Sbjct: 30 EQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQS 89
Query: 80 YR------SMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQ 133
+R S W L+ T Q ++ + E +++ + + +K+ D
Sbjct: 90 FRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDL 149
Query: 134 LTKIQTELQETVKDLAKGKKKY----FETEQMAHAVREKADIEAKSKLSLFQSRIS---- 185
++Q EL E V +L KK Y E+ +RE E K + +
Sbjct: 150 EQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATE 209
Query: 186 ---LQKASVKL--------KARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIM 234
L+K+S+K +A+ E K T ARN+YLL+LA+ NA YY D++++M
Sbjct: 210 AGPLRKSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLM 269
Query: 235 KALDGNVY----DHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQE- 289
D + L+ Y A SRT+ Q + + LE + + + + + E
Sbjct: 270 DCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGS-----LEEAVEALDPPGDKAKVLEV 324
Query: 290 -NAVFHKPQPFQFQPCDSDTSRQLESETGTTEE 321
VF P F + P D D ++ E +E
Sbjct: 325 HATVFCPPLRFDYHPHDGDEVAEICVEMELRDE 357
Score = 40.4 bits (93), Expect = 0.006
Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 17/107 (15%)
Query: 518 GYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVS--GSLNG--DASVCFVK 573
G V EK + P+++ L A L+S + EAE+ + L G +A CF
Sbjct: 703 GPVYEKCMAPPSASCLGD-----AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFA- 756
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620
Y G+T ELSF G ++R+ + + D +W GE NG G+ P
Sbjct: 757 ----YTGRTAQELSFRRGDVLRLHERASSD---WWRGEHNGMRGLIP 796
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
Length = 1085
Score = 75.1 bits (183), Expect = 2e-13
Identities = 83/342 (24%), Positives = 143/342 (41%), Gaps = 53/342 (15%)
Query: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
+E++ VEQ L+ + + LL+D++ F +KKA IE EY++ ++KLA +++ +
Sbjct: 22 KEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRST 81
Query: 72 VKADD-RNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLK 128
+ D + PV W L + ++ + + Y N + + + K
Sbjct: 82 KDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFK 141
Query: 129 RCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLS---------- 178
+ + ++ +L + + +L K Y M HA I A+SKL
Sbjct: 142 KSKEIAFQLHEDLMKVLNELYTVMKTY----HMYHA----ESISAESKLKEAEKQEEKQI 193
Query: 179 ------LFQSRI-----------SLQKASVKLKARRSECNSKATHARNDYLLTLAAANAH 221
+F R+ ++K K +A+ SE K+ ARN+YLLTL A NA
Sbjct: 194 GRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNAS 253
Query: 222 QDRYYQTDLVNIMKALD----GNVYDHLKDYLIAFSRTEL---ETCQAVQNTFQFLLENS 274
+YY DL +++ D ++ L+ YL A E E ++N L S
Sbjct: 254 VFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRS 313
Query: 275 SKVVRDYNLQLFLQ-ENAVFHKPQPFQFQPCDSDTSRQLESE 315
K Q F++ A F P F+FQ D Q+ ++
Sbjct: 314 DK-------QRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQ 348
Score = 38.5 bits (88), Expect = 0.023
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 15/125 (12%)
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPS--VLVEELSASE 631
A +DY G++ ELSF +GA + + ++ ++D +WEG NG G+ P ++V+++ +
Sbjct: 750 AKFDYVGRSARELSFKKGASLLLYHRASED---WWEGRHNGIDGLVPHQYIVVQDMDDTF 806
Query: 632 NGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSP-DKRSSLYFPRSPSANEKSLH 690
+ DT +S AS P+ D+ S SP D+ Y R E
Sbjct: 807 S-DT-------LSQKADSEASSGPV-TEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPP 857
Query: 691 AESPG 695
PG
Sbjct: 858 VRRPG 862
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 72.4 bits (176), Expect = 1e-12
Identities = 51/193 (26%), Positives = 88/193 (45%), Gaps = 34/193 (17%)
Query: 460 SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDW---VKARNKVGQ 516
S+S SG P +V +Y AS ++L++ +++ +++ W ++AR K Q
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 517 VGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALY 576
G+ P SH +E + + + VC V A+Y
Sbjct: 1077 KGWFPA------------------------SHVKLLGPSSERATPAFH---PVCQVIAMY 1109
Query: 577 DYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTP 636
DY +DELSF +G +I ++NK DD +W+GE NG G+FPS V +++ +
Sbjct: 1110 DYAANNEDELSFSKGQLINVMNK---DDPDWWQGEINGVTGLFPSNYV-KMTTDSDPSQQ 1165
Query: 637 WMREIQISPSPKP 649
W ++Q + +P
Sbjct: 1166 WCADLQTLDTMQP 1178
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/240 (23%), Positives = 99/240 (41%), Gaps = 27/240 (11%)
Query: 442 EREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIED 501
E+E + + MD F++ T L + +Y K + E+ E + LE+++
Sbjct: 603 EKETASKLSE-MDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEI---ERKRLELMQK 658
Query: 502 GDMEDWVKARNKVGQVGY--------VPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNS 553
+ED + K G+ EK + + + + + + ++
Sbjct: 659 KKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT 718
Query: 554 TEAELVSGSLNGDASVCF-VKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEF 612
+AE ASV +ALY +E + DE+SF G II++ +++ + G+ G F
Sbjct: 719 LKAE---EKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSF 774
Query: 613 NGRIGVFPSVLVEELSASENGDTPWMREIQISPSP---KPHASLPPLPLYDQPPSSPYPS 669
G G FP VE++ +SEN E +SP P SL +P SS P+
Sbjct: 775 QGNFGWFPCNYVEKMPSSEN-------EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPA 827
Score = 45.8 bits (107), Expect = 1e-04
Identities = 110/598 (18%), Positives = 216/598 (36%), Gaps = 91/598 (15%)
Query: 89 SFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDL 148
++ G M++ + R + E + A+ + E++ + +Q K Q EL++ ++
Sbjct: 370 NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
Query: 149 AKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHAR 208
+ +++ E + RE A E + + L RI Q+ + + E + +
Sbjct: 430 RELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
Query: 209 NDYLLTLAAANAHQD---RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQN 265
N +L A HQ R L + + V D D I + + Q QN
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 266 TFQFLLENSSKV-VRDYNLQLFLQENA---VFHKPQPFQFQPCD--SDTSRQLESETGT- 318
+L+ + R N+Q ++ + HK + + C + LE ET +
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASK 609
Query: 319 -TEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEAREN 377
+E S N + ++ + + ++ D E+ R EL QK E
Sbjct: 610 LSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK----LKEIERKRLELMQKKKLEDEA 665
Query: 378 IRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSL 437
RKA+ + N E L E + + T +
Sbjct: 666 ARKAK------------------------QGKENLWKENLRKEEEEKQKRLQEEKTQEKI 701
Query: 438 NADTEREEGEEFEDNMDV-FDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVL 496
+ + E ++ +D + ++ + L NY + +Y ++A DE++ +++
Sbjct: 702 QEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY----RALYPFEARNHDEMSFNSGDII 757
Query: 497 EVIEDGDMEDWVKARNKVGQVGYVPEKYLQ-FPTSNSLLSMLQSLAALDSRSHTSSNSTE 555
+V E E + G G+ P Y++ P+S + ++ A L S+ ST
Sbjct: 758 QVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTS 817
Query: 556 AELVSGS---------------------------------------LNGDASVCF---VK 573
+E +S + ++G V +
Sbjct: 818 SEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQ 877
Query: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASE 631
AL + + D+ L+F + II +L ++ + +W GE +G G FP V+ + SE
Sbjct: 878 ALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKIIPGSE 931
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/156 (24%), Positives = 71/156 (45%), Gaps = 23/156 (14%)
Query: 472 LTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQF-PTS 530
L + + S+ A + + L +H+++ V+E E+W G+ G+ P+ Y++ P S
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQ--QENWWFGEVHGGR-GWFPKSYVKIIPGS 930
Query: 531 NSLLSMLQSL-AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFP 589
++L AA++ + +++ S E + ALY Y +L+F
Sbjct: 931 EVKREEPEALYAAVNKKPTSAAYSVGEEYI--------------ALYPYSSVEPGDLTFT 976
Query: 590 EGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVE 625
EG I + K+ + +W G R G+FPS V+
Sbjct: 977 EGEEILVTQKDGE----WWTGSIGDRSGIFPSNYVK 1008
Score = 30.0 bits (66), Expect = 8.1
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 32/269 (11%)
Query: 280 DYNLQLFLQENAVFHKPQPF----QFQPCDSDTSRQLESETGTTEEHS-LNKEARKWATR 334
++ L + L + A +P P + P +Q++S GT + + +E +
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 335 VAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARE-------NIRKAEIIK-L 386
V E K + +R +LE A+ EQ + E E+K + +E +++ E K L
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 387 KAEARLDLLKQIGVSVDTWLKSAMNQ---VMEELENERWARPPAVTSNGTLHSLNADTE- 442
+ E RL+ +++ + + + + +ELE +R + L+ N + E
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 443 ----REEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEV-LE 497
+ + ++ + SG L++ L K +Q EL + + + LE
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLK-------KQTQKTELEVLDKQCDLE 533
Query: 498 VIEDGDMEDWVKA-RNKVGQVGYVPEKYL 525
++E ++ ++ +NK+ + VPEK L
Sbjct: 534 IMEIKQLQQELQEYQNKL--IYLVPEKQL 560
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 72.4 bits (176), Expect = 1e-12
Identities = 51/193 (26%), Positives = 88/193 (45%), Gaps = 34/193 (17%)
Query: 460 SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDW---VKARNKVGQ 516
S+S SG P +V +Y AS ++L++ +++ +++ W ++AR K Q
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 517 VGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALY 576
G+ P SH +E + + + VC V A+Y
Sbjct: 1104 KGWFPA------------------------SHVKLLGPSSERATPAFH---PVCQVIAMY 1136
Query: 577 DYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTP 636
DY +DELSF +G +I ++NK DD +W+GE NG G+FPS V +++ +
Sbjct: 1137 DYAANNEDELSFSKGQLINVMNK---DDPDWWQGEINGVTGLFPSNYV-KMTTDSDPSQQ 1192
Query: 637 WMREIQISPSPKP 649
W ++Q + +P
Sbjct: 1193 WCADLQTLDTMQP 1205
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASEN 632
+ALY +E + DE+SF G II++ +++ + G+ G F G G FP VE++ +SEN
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Query: 633 GDTPWMREIQISPSP---KPHASLPPLPLYDQPPSSPYPS 669
E +SP P SL +P SS P+
Sbjct: 822 -------EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPA 854
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/156 (24%), Positives = 71/156 (45%), Gaps = 23/156 (14%)
Query: 472 LTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQF-PTS 530
L + + S+ A + + L +H+++ V+E E+W G+ G+ P+ Y++ P S
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQ--QENWWFGEVHGGR-GWFPKSYVKIIPGS 957
Query: 531 NSLLSMLQSL-AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFP 589
++L AA++ + +++ S E + ALY Y +L+F
Sbjct: 958 EVKREEPEALYAAVNKKPTSAAYSVGEEYI--------------ALYPYSSVEPGDLTFT 1003
Query: 590 EGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVE 625
EG I + K+ + +W G R G+FPS V+
Sbjct: 1004 EGEEILVTQKDGE----WWTGSIGDRSGIFPSNYVK 1035
Score = 45.1 bits (105), Expect = 2e-04
Identities = 114/604 (18%), Positives = 229/604 (37%), Gaps = 76/604 (12%)
Query: 89 SFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDL 148
++ G M++ + R + E + A+ + E++ + +Q K Q EL++ ++
Sbjct: 370 NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
Query: 149 AKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHAR 208
+ +++ E + RE A E + + L RI Q+ + + E + +
Sbjct: 430 RELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
Query: 209 NDYLLTLAAANAHQD---RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQN 265
N +L A HQ R L + + V D D I + + Q QN
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 266 TFQFLLENSSKV-VRDYNLQLFLQENA---VFHKPQPFQFQPCD--SDTSRQLESETGT- 318
+L+ + R N+Q ++ + HK + + C + LE ET +
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASK 609
Query: 319 -TEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLEC-HGAAVSEQSRAELEQKIDEARE 376
+E S N + + +++ Q +L+ L C + + + E A E
Sbjct: 610 LSEMDSFNNQLK-----CGNMDDSVL--QCLLSLLSCLNNLFLLLKELRETYNTQQLALE 662
Query: 377 NIRKAEIIKLKA--EARLDLLKQIGVSVDTWLKSAM---NQVMEELENERWARPPAVTSN 431
+ K + KLK RL+L+++ + + K+ N E L E + +
Sbjct: 663 QLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE 722
Query: 432 GTLHSLNADTEREEGEEFEDNMDV-FDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTI 490
T + + + E ++ +D + ++ + L NY + +Y ++A DE++
Sbjct: 723 KTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY----RALYPFEARNHDEMSF 778
Query: 491 EEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQ-FPTSNSLLSMLQSLAALDSRSHT 549
++++V E E + G G+ P Y++ P+S + ++ A L
Sbjct: 779 NSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSL 838
Query: 550 SSNSTEAELVSGS---------------------------------------LNGDASVC 570
S+ ST +E +S + ++G V
Sbjct: 839 SATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVV 898
Query: 571 F---VKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEEL 627
+AL + + D+ L+F + II +L ++ + +W GE +G G FP V+ +
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKII 954
Query: 628 SASE 631
SE
Sbjct: 955 PGSE 958
Score = 30.0 bits (66), Expect = 8.1
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 32/269 (11%)
Query: 280 DYNLQLFLQENAVFHKPQPF----QFQPCDSDTSRQLESETGTTEEHS-LNKEARKWATR 334
++ L + L + A +P P + P +Q++S GT + + +E +
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 335 VAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARE-------NIRKAEIIK-L 386
V E K + +R +LE A+ EQ + E E+K + +E +++ E K L
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 387 KAEARLDLLKQIGVSVDTWLKSAMNQ---VMEELENERWARPPAVTSNGTLHSLNADTE- 442
+ E RL+ +++ + + + + +ELE +R + L+ N + E
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 443 ----REEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEV-LE 497
+ + ++ + SG L++ L K +Q EL + + + LE
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLK-------KQTQKTELEVLDKQCDLE 533
Query: 498 VIEDGDMEDWVKA-RNKVGQVGYVPEKYL 525
++E ++ ++ +NK+ + VPEK L
Sbjct: 534 IMEIKQLQQELQEYQNKL--IYLVPEKQL 560
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 72.4 bits (176), Expect = 1e-12
Identities = 51/193 (26%), Positives = 88/193 (45%), Gaps = 34/193 (17%)
Query: 460 SSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDW---VKARNKVGQ 516
S+S SG P +V +Y AS ++L++ +++ +++ W ++AR K Q
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 517 VGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALY 576
G+ P SH +E + + + VC V A+Y
Sbjct: 1104 KGWFPA------------------------SHVKLLGPSSERATPAFH---PVCQVIAMY 1136
Query: 577 DYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTP 636
DY +DELSF +G +I ++NK DD +W+GE NG G+FPS V +++ +
Sbjct: 1137 DYAANNEDELSFSKGQLINVMNK---DDPDWWQGEINGVTGLFPSNYV-KMTTDSDPSQQ 1192
Query: 637 WMREIQISPSPKP 649
W ++Q + +P
Sbjct: 1193 WCADLQTLDTMQP 1205
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASEN 632
+ALY +E + DE+SF G II++ +++ + G+ G F G G FP VE++ +SEN
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Query: 633 GDTPWMREIQISPSP---KPHASLPPLPLYDQPPSSPYPS 669
E +SP P SL +P SS P+
Sbjct: 822 -------EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPA 854
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/156 (24%), Positives = 71/156 (45%), Gaps = 23/156 (14%)
Query: 472 LTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQF-PTS 530
L + + S+ A + + L +H+++ V+E E+W G+ G+ P+ Y++ P S
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQ--QENWWFGEVHGGR-GWFPKSYVKIIPGS 957
Query: 531 NSLLSMLQSL-AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFP 589
++L AA++ + +++ S E + ALY Y +L+F
Sbjct: 958 EVKREEPEALYAAVNKKPTSAAYSVGEEYI--------------ALYPYSSVEPGDLTFT 1003
Query: 590 EGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVE 625
EG I + K+ + +W G R G+FPS V+
Sbjct: 1004 EGEEILVTQKDGE----WWTGSIGDRSGIFPSNYVK 1035
Score = 45.1 bits (105), Expect = 2e-04
Identities = 114/604 (18%), Positives = 229/604 (37%), Gaps = 76/604 (12%)
Query: 89 SFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDL 148
++ G M++ + R + E + A+ + E++ + +Q K Q EL++ ++
Sbjct: 370 NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
Query: 149 AKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHAR 208
+ +++ E + RE A E + + L RI Q+ + + E + +
Sbjct: 430 RELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
Query: 209 NDYLLTLAAANAHQD---RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQN 265
N +L A HQ R L + + V D D I + + Q QN
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 266 TFQFLLENSSKV-VRDYNLQLFLQENA---VFHKPQPFQFQPCD--SDTSRQLESETGT- 318
+L+ + R N+Q ++ + HK + + C + LE ET +
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASK 609
Query: 319 -TEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLEC-HGAAVSEQSRAELEQKIDEARE 376
+E S N + + +++ Q +L+ L C + + + E A E
Sbjct: 610 LSEMDSFNNQLK-----CGNMDDSVL--QCLLSLLSCLNNLFLLLKELRETYNTQQLALE 662
Query: 377 NIRKAEIIKLKA--EARLDLLKQIGVSVDTWLKSAM---NQVMEELENERWARPPAVTSN 431
+ K + KLK RL+L+++ + + K+ N E L E + +
Sbjct: 663 QLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE 722
Query: 432 GTLHSLNADTEREEGEEFEDNMDV-FDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTI 490
T + + + E ++ +D + ++ + L NY + +Y ++A DE++
Sbjct: 723 KTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY----RALYPFEARNHDEMSF 778
Query: 491 EEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQ-FPTSNSLLSMLQSLAALDSRSHT 549
++++V E E + G G+ P Y++ P+S + ++ A L
Sbjct: 779 NSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSL 838
Query: 550 SSNSTEAELVSGS---------------------------------------LNGDASVC 570
S+ ST +E +S + ++G V
Sbjct: 839 SATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVV 898
Query: 571 F---VKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEEL 627
+AL + + D+ L+F + II +L ++ + +W GE +G G FP V+ +
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKII 954
Query: 628 SASE 631
SE
Sbjct: 955 PGSE 958
Score = 30.0 bits (66), Expect = 8.1
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 32/269 (11%)
Query: 280 DYNLQLFLQENAVFHKPQPF----QFQPCDSDTSRQLESETGTTEEHS-LNKEARKWATR 334
++ L + L + A +P P + P +Q++S GT + + +E +
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 335 VAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARE-------NIRKAEIIK-L 386
V E K + +R +LE A+ EQ + E E+K + +E +++ E K L
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 387 KAEARLDLLKQIGVSVDTWLKSAMNQ---VMEELENERWARPPAVTSNGTLHSLNADTE- 442
+ E RL+ +++ + + + + +ELE +R + L+ N + E
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 443 ----REEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEV-LE 497
+ + ++ + SG L++ L K +Q EL + + + LE
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLK-------KQTQKTELEVLDKQCDLE 533
Query: 498 VIEDGDMEDWVKA-RNKVGQVGYVPEKYL 525
++E ++ ++ +NK+ + VPEK L
Sbjct: 534 IMEIKQLQQELQEYQNKL--IYLVPEKQL 560
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 72.0 bits (175), Expect = 2e-12
Identities = 66/256 (25%), Positives = 105/256 (41%), Gaps = 47/256 (18%)
Query: 474 CKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSL 533
CKV +SY Q DEL ++ E++E+I++ + W+ +N GQ+G P +++ S
Sbjct: 88 CKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKN--GQLGAFPSNFVELLDSGP- 144
Query: 534 LSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVC-------FVKALYDYEGQTDDEL 586
SL D S + +L S + + + L+DY+ + DEL
Sbjct: 145 ----PSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDEL 200
Query: 587 SFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPS 646
+ G ++++L+K +D G+WEGE GR GVFP V
Sbjct: 201 ALRRGDVVKVLSK-TTEDKGWWEGECQGRRGVFPDNFV---------------------- 237
Query: 647 PKPHASLPPLPLYDQPPS---SPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQA-SRH 702
LPP P+ P S +P K P++ K L + G S+A +
Sbjct: 238 ------LPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
Query: 703 TPETSYGKLRPVRAAP 718
TP KL + P
Sbjct: 292 TPSRDSQKLTSRDSGP 307
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/198 (25%), Positives = 82/198 (41%), Gaps = 38/198 (19%)
Query: 476 VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKV-----GQVGYVPEKYLQ-FPT 529
V+ Y+A + DEL++ +V+ + WV AR + G+ G PE+ +Q P
Sbjct: 5 VLAGYRAQKEDELSLAPGDVVRQVR------WVPARGWLRGEFGGRYGLFPERLVQEIPE 58
Query: 530 SNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFP 589
+ + R H + + + K + Y + DEL
Sbjct: 59 TLRGSGEARRPRCARRRGHPAKHPRPQR-------------WCKVNFSYSPEQADELKLQ 105
Query: 590 EGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASE----NGDTPWMREIQISP 645
G I+ ++ + +DG+W G+ NG++G FPS VE L + N D P +SP
Sbjct: 106 AGEIVEMIK---EIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMP-----SVSP 157
Query: 646 SPKPHASLPPLPLYDQPP 663
P+ L L YD PP
Sbjct: 158 GPQRPPKLSSL-AYDSPP 174
Score = 39.7 bits (91), Expect = 0.010
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Query: 572 VKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASE 631
V L Y Q +DELS G ++R + G+ GEF GR G+FP LV+E+ +
Sbjct: 3 VLVLAGYRAQKEDELSLAPGDVVRQVRW--VPARGWLRGEFGGRYGLFPERLVQEIPETL 60
Query: 632 NG 633
G
Sbjct: 61 RG 62
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 22/164 (13%)
Query: 478 YSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTS---NSLL 534
+ Y A Q EL I+++E L +++D + W + RN + GYVP Y++ S SL+
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDS--KTWWRVRNAANRTGYVPSNYVERKNSLKKGSLV 68
Query: 535 SMLQSLAAL-------DSRSHTSSNSTEAELVSGSLNGDASV-----CFVKALYDYEGQT 582
L+ L +R + + ST+AE + D FVK + Y +
Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK--FAYVAER 126
Query: 583 DDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEE 626
+DELS +G+ + ++ K DG+W G +NG+IG FPS V E
Sbjct: 127 EDELSLVKGSRVTVMEK---CSDGWWRGSYNGQIGWFPSNYVLE 167
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 16/167 (9%)
Query: 464 SGTLRNYPLTCK--VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVP 521
SG R Y L V ++Y A + DEL++ + + V+E W + N GQ+G+ P
Sbjct: 104 SGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYN--GQIGWFP 161
Query: 522 EKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQ 581
Y+ AA +S S S A L +G G + V+ LY +
Sbjct: 162 SNYVLEEVDE---------AAAESPSFLSLRKG-ASLSNGQ--GSRVLHVVQTLYPFSSV 209
Query: 582 TDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELS 628
T++EL+F +G + ++ K D + + G++G+ P V LS
Sbjct: 210 TEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLS 256
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 22/164 (13%)
Query: 478 YSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTS---NSLL 534
+ Y A Q EL I+++E L +++D + W + RN + GYVP Y++ S SL+
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDS--KTWWRVRNAANRTGYVPSNYVERKNSLKKGSLV 68
Query: 535 SMLQSLAAL-------DSRSHTSSNSTEAELVSGSLNGDASV-----CFVKALYDYEGQT 582
L+ L +R + + ST+AE + D FVK + Y +
Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK--FAYVAER 126
Query: 583 DDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEE 626
+DELS +G+ + ++ K DG+W G +NG+IG FPS V E
Sbjct: 127 EDELSLVKGSRVTVMEK---CSDGWWRGSYNGQIGWFPSNYVLE 167
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 16/167 (9%)
Query: 464 SGTLRNYPLTCK--VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVP 521
SG R Y L V ++Y A + DEL++ + + V+E W + N GQ+G+ P
Sbjct: 104 SGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYN--GQIGWFP 161
Query: 522 EKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQ 581
Y+ AA +S S S A L +G G + V+ LY +
Sbjct: 162 SNYVLEEVDE---------AAAESPSFLSLRKG-ASLSNGQ--GSRVLHVVQTLYPFSSV 209
Query: 582 TDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELS 628
T++EL+F +G + ++ K D + + G++G+ P V LS
Sbjct: 210 TEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLS 256
>gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens]
Length = 870
Score = 69.7 bits (169), Expect = 9e-12
Identities = 51/164 (31%), Positives = 76/164 (46%), Gaps = 12/164 (7%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP----SVLVEELS 628
KALYD ++ DELSF +G I+ +L ++ Q DG+W +GR G+ P +LV
Sbjct: 9 KALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYD 68
Query: 629 ASENGDTPWMREIQISPSPKPHASLPPLPLY-DQPPSSPYPSPDKRSSLYFPRSPSANEK 687
G P P P HA PP Y P++ P PD S+Y +PS ++
Sbjct: 69 KKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPD---SVYLVPTPSKAQQ 125
Query: 688 SLHAESPGFSQASRHTP---ETSYGKLRPVRAAPPPPTQNHRRP 728
L+ + PG S + P +++ K P P P T ++ P
Sbjct: 126 GLY-QVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVP 168
>gi|239745060 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 353
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/158 (31%), Positives = 74/158 (46%), Gaps = 12/158 (7%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP----SVLVEELS 628
KALYD ++ DELSF +G I+ +L ++ Q DG+W +GR G+ P +LV
Sbjct: 9 KALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIMPGNHLKILVGMYD 68
Query: 629 ASENGDTPWMREIQISPSPKPHASLPPLPLY-DQPPSSPYPSPDKRSSLYFPRSPSANEK 687
G P P P HA +PP Y P++ P PD S+Y +PS ++
Sbjct: 69 KKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPD---SVYLVPTPSKAQQ 125
Query: 688 SLHAESPGFSQASRHTP---ETSYGKLRPVRAAPPPPT 722
L+ + PG S + P +++ K P P P T
Sbjct: 126 GLY-QVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT 162
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/170 (28%), Positives = 82/170 (48%), Gaps = 23/170 (13%)
Query: 478 YSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSML 537
+ Y A Q EL I+++E L +++D + W + RN + + G+VP Y++ S S++
Sbjct: 11 FDYVAQQEQELDIKKNERLWLLDDS--KSWWRVRNSMNKTGFVPSNYVERKNSARKASIV 68
Query: 538 QSL-------------AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDD 584
++L + DS S + + LN A V F +Y + +D
Sbjct: 69 KNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKF-----NYMAERED 123
Query: 585 ELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGD 634
ELS +G + ++ K + DG+W G +NG++G FPS V E S GD
Sbjct: 124 ELSLIKGTKVIVMEKCS---DGWWRGSYNGQVGWFPSNYVTEEGDSPLGD 170
Score = 60.8 bits (146), Expect = 4e-09
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 451 DNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKA 510
D+ DDS P L + + V ++Y A + DEL++ + + V+E W +
Sbjct: 88 DSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGS 147
Query: 511 RNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVC 570
N GQVG+ P Y+ + L H S S + V +LN +
Sbjct: 148 YN--GQVGWFPSNYVTEEGDSPL------------GDHVGSLSEKLAAVVNNLNTGQVLH 193
Query: 571 FVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620
V+ALY + D+EL+F +G ++ ++ K D + + + NG +G+ P
Sbjct: 194 VVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVP 243
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 475 KVVYSYKASQPDELTIEEHEVLEVIEDGDME-DWVKARNKVGQVGYVPEKYLQFPTSNSL 533
+ +Y + +S +EL E+ +V++VIE + + +W K R G VG VP+ Y+ +N L
Sbjct: 196 QALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPL 255
Query: 534 LSMLQ 538
S L+
Sbjct: 256 TSGLE 260
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/204 (27%), Positives = 83/204 (40%), Gaps = 46/204 (22%)
Query: 536 MLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIR 595
+LQSL + TE ++ + + + L+ YEG +DEL+F EG II
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKE--------YCRTLFAYEGTNEDELTFKEGEIIH 297
Query: 596 ILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPP 655
+++KE + G+W GE NG+ GVFP +++ + P PK PP
Sbjct: 298 LISKET-GEAGWWRGELNGKEGVFPDNFAVQINELDKD----------FPKPKK----PP 342
Query: 656 LPLYDQPPSSPYPSPD--KRSSLYFPRSP-SANEKSLHAESPGFSQA-----SRHTPETS 707
P +P P P+ YF P +EKS + P A + TP T
Sbjct: 343 -----PPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTK 397
Query: 708 YGKL----------RPVRAAPPPP 721
L RP + PPPP
Sbjct: 398 ASNLLRSSGTVYPKRPEKPVPPPP 421
Score = 65.1 bits (157), Expect = 2e-10
Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 16/215 (7%)
Query: 476 VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQ--------- 526
V Y Y A DELTI E++ ++ E W++ G+ G P+ +++
Sbjct: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELN-GRRGMFPDNFVKEIKRETEFK 64
Query: 527 ---FPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTD 583
P + SL S + + + ++ K L++Y Q +
Sbjct: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
Query: 584 DELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQI 643
DEL G II I + ++G+W G N ++G+FPS V+EL +++G+T ++
Sbjct: 125 DELELKVGDIIDI---NEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSE 181
Query: 644 SPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYF 678
+ P + +P L + S P K + F
Sbjct: 182 TVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGF 216
Score = 32.3 bits (72), Expect = 1.6
Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 4/53 (7%)
Query: 474 CKVVYSYKASQPDELTIEEHEVLEVI--EDGDMEDWVKARNKVGQVGYVPEKY 524
C+ +++Y+ + DELT +E E++ +I E G+ W N G+ G P+ +
Sbjct: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELN--GKEGVFPDNF 324
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 65.9 bits (159), Expect = 1e-10
Identities = 104/482 (21%), Positives = 195/482 (40%), Gaps = 47/482 (9%)
Query: 13 ELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGV 72
+LKN E + KLQ E LLE ++ F + ++EYA +Q L +Q K
Sbjct: 6 DLKNSH-EAVLKLQ---DWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKES---- 57
Query: 73 KADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVD 132
N ++ W ++ T Q+++ E+ + + K+Q K +
Sbjct: 58 -TVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIG 116
Query: 133 QLTKIQTELQETVK-DLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASV 191
+I+ E+ + K +L K K Y + + ++ +EK ++ ++ K +
Sbjct: 117 VHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEK-----------YKEALAKGKETE 165
Query: 192 KLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTD---LVNIMKALDGNVYDHLKDY 248
K K R + K N Y+L L A HQ++YY L++ ++ + + LK
Sbjct: 166 KAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGI 225
Query: 249 LIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDT 308
+S+ + + N + + + ++ F+ H+ + Q + DT
Sbjct: 226 FDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFID----VHRTTAAKEQEIEFDT 281
Query: 309 SRQLESETGTTEE---HSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRA 365
S E+E E ++L E+ + + E + + QQ +LN E++
Sbjct: 282 SLLEENENLQANEIMWNNLTAESLQVMLKTLAE-ELMQTQQMLLN---------KEEAVL 331
Query: 366 ELEQKIDEARENIRKAE--IIKLKAEARLDLLKQIGVSVD-TWLK-SAMNQVMEE--LEN 419
ELE++I+E+ E K ++ L + L+ LKQ + T K SA +++E+ EN
Sbjct: 332 ELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQEN 391
Query: 420 ERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYS 479
+ PP V S+ + +E +FE SP L + L+ + S
Sbjct: 392 DGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISIS 451
Query: 480 YK 481
K
Sbjct: 452 EK 453
>gi|239756225 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 232
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 12/158 (7%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP----SVLVEELS 628
KALY ++ DELSF +G I+ +L ++ Q DG+W +GR G+ P +LV
Sbjct: 9 KALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHLKILVGMYD 68
Query: 629 ASENGDTPWMREIQISPSPKPHASLPPLPLY-DQPPSSPYPSPDKRSSLYFPRSPSANEK 687
G P P P HA +PP Y P++ P PD S+Y +PS ++
Sbjct: 69 KKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPD---SVYLVPTPSKAQQ 125
Query: 688 SLHAESPGFSQASRHTP---ETSYGKLRPVRAAPPPPT 722
L+ + PG S + P +++ K P P P T
Sbjct: 126 GLY-QVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT 162
>gi|239750776 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 224
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 12/158 (7%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP----SVLVEELS 628
KALY ++ DELSF +G I+ +L ++ Q DG+W +GR G+ P +LV
Sbjct: 9 KALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHLKILVGMYD 68
Query: 629 ASENGDTPWMREIQISPSPKPHASLPPLPLY-DQPPSSPYPSPDKRSSLYFPRSPSANEK 687
G P P P HA +PP Y P++ P PD S+Y +PS ++
Sbjct: 69 KKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPD---SVYLVPTPSKAQQ 125
Query: 688 SLHAESPGFSQASRHTP---ETSYGKLRPVRAAPPPPT 722
L+ + PG S + P +++ K P P P T
Sbjct: 126 GLY-QVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT 162
>gi|239745044 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 368
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 12/158 (7%)
Query: 573 KALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP----SVLVEELS 628
KALY ++ DELSF +G I+ +L ++ Q DG+W +GR G+ P +LV
Sbjct: 9 KALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHLKILVGMYD 68
Query: 629 ASENGDTPWMREIQISPSPKPHASLPPLPLY-DQPPSSPYPSPDKRSSLYFPRSPSANEK 687
G P P P HA +PP Y P++ P PD S+Y +PS ++
Sbjct: 69 KKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPD---SVYLVPTPSKAQQ 125
Query: 688 SLHAESPGFSQASRHTP---ETSYGKLRPVRAAPPPPT 722
L+ + PG S + P +++ K P P P T
Sbjct: 126 GLY-QVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPAT 162
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 60.5 bits (145), Expect = 6e-09
Identities = 56/204 (27%), Positives = 90/204 (44%), Gaps = 12/204 (5%)
Query: 531 NSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPE 590
N L + +++ + + +S++ E+ S + + D + K ++ YE Q DDEL+ E
Sbjct: 198 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKD----YCKVIFPYEAQNDDELTIKE 253
Query: 591 GAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEEL--SASENGDTPWMREIQISPSPK 648
G I+ ++NK+ D G+WEGE NGR GVFP V+ L + G+ P +P K
Sbjct: 254 GDIVTLINKD-CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIK 312
Query: 649 PHASLPPL--PLYDQPPSSPYPSPDKRSSLYFP-RSPSAN--EKSLHAESPGFSQASRHT 703
A + PP P P++ P R P + + S+ A P + +
Sbjct: 313 QGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTN 372
Query: 704 PETSYGKLRPVRAAPPPPTQNHRR 727
+ G L P R P H R
Sbjct: 373 SLSRPGALPPRRPERPVGPLTHTR 396
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/71 (36%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 576 YDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDT 635
+ Y Q DDEL G II ++ + ++G+WEG NG+ G+FPS ++ELS E+ +
Sbjct: 70 FSYLPQNDDELELKVGDIIEVVGEV---EEGWWEGVLNGKTGMFPSNFIKELS-GESDEL 125
Query: 636 PWMREIQISPS 646
++ Q+S S
Sbjct: 126 GISQDEQLSKS 136
Score = 34.7 bits (78), Expect = 0.33
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 4/71 (5%)
Query: 458 DSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDG--DMEDWVKARNKVG 515
DSS + + CKV++ Y+A DELTI+E +++ +I D+ W N G
Sbjct: 219 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN--G 276
Query: 516 QVGYVPEKYLQ 526
+ G P+ +++
Sbjct: 277 RRGVFPDNFVK 287
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 5/95 (5%)
Query: 474 CKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNS- 532
C+V +SY DEL ++ +++EV+ + + W N G+ G P +++ + S
Sbjct: 66 CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLN--GKTGMFPSNFIKELSGESD 123
Query: 533 --LLSMLQSLAALDSRSHTSSNSTEAELVSGSLNG 565
+S + L+ R T S S + S G
Sbjct: 124 ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEG 158
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 60.5 bits (145), Expect = 6e-09
Identities = 56/204 (27%), Positives = 90/204 (44%), Gaps = 12/204 (5%)
Query: 531 NSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPE 590
N L + +++ + + +S++ E+ S + + D + K ++ YE Q DDEL+ E
Sbjct: 235 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKD----YCKVIFPYEAQNDDELTIKE 290
Query: 591 GAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEEL--SASENGDTPWMREIQISPSPK 648
G I+ ++NK+ D G+WEGE NGR GVFP V+ L + G+ P +P K
Sbjct: 291 GDIVTLINKD-CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIK 349
Query: 649 PHASLPPL--PLYDQPPSSPYPSPDKRSSLYFP-RSPSAN--EKSLHAESPGFSQASRHT 703
A + PP P P++ P R P + + S+ A P + +
Sbjct: 350 QGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTN 409
Query: 704 PETSYGKLRPVRAAPPPPTQNHRR 727
+ G L P R P H R
Sbjct: 410 SLSRPGALPPRRPERPVGPLTHTR 433
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/174 (26%), Positives = 79/174 (45%), Gaps = 9/174 (5%)
Query: 476 VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLS 535
V + Y+A DELTI E++ I D W N G+ G P+ +++
Sbjct: 6 VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQIN--GRRGLFPDNFVREIKKEMKKD 63
Query: 536 MLQSLAALDSRSHTSSNST---EAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGA 592
L + A S ++ ++ + G+ + + Y Q DDEL G
Sbjct: 64 PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGD 123
Query: 593 IIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPS 646
II ++ + ++G+WEG NG+ G+FPS ++ELS E+ + ++ Q+S S
Sbjct: 124 IIEVVGEV---EEGWWEGVLNGKTGMFPSNFIKELS-GESDELGISQDEQLSKS 173
Score = 34.7 bits (78), Expect = 0.33
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 4/71 (5%)
Query: 458 DSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDG--DMEDWVKARNKVG 515
DSS + + CKV++ Y+A DELTI+E +++ +I D+ W N G
Sbjct: 256 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN--G 313
Query: 516 QVGYVPEKYLQ 526
+ G P+ +++
Sbjct: 314 RRGVFPDNFVK 324
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 5/95 (5%)
Query: 474 CKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNS- 532
C+V +SY DEL ++ +++EV+ + + W N G+ G P +++ + S
Sbjct: 103 CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLN--GKTGMFPSNFIKELSGESD 160
Query: 533 --LLSMLQSLAALDSRSHTSSNSTEAELVSGSLNG 565
+S + L+ R T S S + S G
Sbjct: 161 ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEG 195
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 58.2 bits (139), Expect = 3e-08
Identities = 81/340 (23%), Positives = 137/340 (40%), Gaps = 48/340 (14%)
Query: 312 LESETGTTEEHSLNKEA-RKWATRVAREHKNIVHQ----QRVLNDLECHGAAVSEQSRAE 366
+ E + + SLN E +K ++ + ++++ ++ L +L+ E
Sbjct: 170 ISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQV 229
Query: 367 LEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARP- 425
EQ + +R + L+ + LDL G + + +E+ RW R
Sbjct: 230 FEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRAN 289
Query: 426 --PAVTSNGTLHS-----LNADTEREEGEEFEDNMDVFD-----DSS--SSPSGTLRNYP 471
P + N LN R E ++ D + + D S S PS TL
Sbjct: 290 HGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPS 349
Query: 472 LTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSN 531
+ S + P E +E + + + +D KA+N EK +PT
Sbjct: 350 NPAQSAQSQSSYNPFE---DEDDTGSTVSE---KDDTKAKNVSSY-----EKTQSYPTDW 398
Query: 532 SLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASV---CFVKALYDYEGQTDDELSF 588
S D S+ +ST+A S + DA+ V+ALYDYEGQ DELSF
Sbjct: 399 S-----------DDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSF 447
Query: 589 PEGAIIRILNKENQDDDGFWEGEF-NGRIGVFPSVLVEEL 627
G + E++D+ G+ +G NG++G++P+ VE +
Sbjct: 448 KAGD--ELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAI 485
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,605,919
Number of Sequences: 37866
Number of extensions: 1368779
Number of successful extensions: 8146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 434
Number of HSP's that attempted gapping in prelim test: 6684
Number of HSP's gapped (non-prelim): 1641
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.