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Search of human proteins with 18254476
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18254476 ankyrin repeat and SOCS box-containing protein 5
[Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 664 0.0
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 350 1e-96
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 298 4e-81
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 267 8e-72
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 241 8e-64
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 207 8e-54
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 111 8e-25
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 111 8e-25
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 111 8e-25
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 111 8e-25
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 111 8e-25
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 105 7e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 102 5e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 101 8e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 101 8e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 101 8e-22
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 96 4e-20
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 96 4e-20
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 96 6e-20
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 96 6e-20
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 95 7e-20
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 95 7e-20
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 95 7e-20
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 95 7e-20
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 95 1e-19
gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [H... 94 1e-19
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 93 3e-19
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 92 6e-19
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 92 6e-19
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 92 6e-19
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 664 bits (1714), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYG 60
MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYG
Sbjct: 1 MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYG 60
Query: 61 VTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACAR 120
VTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACAR
Sbjct: 61 VTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACAR 120
Query: 121 TLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGH 180
TLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGH
Sbjct: 121 TLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGH 180
Query: 181 HECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA 240
HECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA
Sbjct: 181 HECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA 240
Query: 241 AQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLC 300
AQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLC
Sbjct: 241 AQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLC 300
Query: 301 IRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
IRSYIGKPRLHLIPQLQLPTLLKNFLQYR
Sbjct: 301 IRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 350 bits (898), Expect = 1e-96
Identities = 175/325 (53%), Positives = 232/325 (71%), Gaps = 4/325 (1%)
Query: 6 ENRPFAQQLSNVYFTILS-LFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVTQG 64
E+ P N++ T+ + F FKL +K+ LA+L+HFYIVKGNRKEAARIA E YG
Sbjct: 2 EDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISD 61
Query: 65 QGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLE 124
WADRSPLHEAA+QGRLLAL+TL++QG NVN VT++ V+ LHEACLG HVACA+ LLE
Sbjct: 62 --CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLE 119
Query: 125 AGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECL 184
GA+VN +T+ G TPLFNAC GS +C +LLE+GAKAQLE L SP HEA +GH EC+
Sbjct: 120 NGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECM 179
Query: 185 DILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQS 244
+IL++ +++D E+P LGTPLYVAC Q+ C+ KLL GA V G++ DTPLHAAA+QS
Sbjct: 180 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQS 239
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSY 304
+ E+++LL ++GA++ +N + +D+A S VE+ LL E P +L QLCRLC+R
Sbjct: 240 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG-PPALSQLCRLCVRKC 298
Query: 305 IGKPRLHLIPQLQLPTLLKNFLQYR 329
+G+ I +L LP L+ FL Y+
Sbjct: 299 LGRACHQAIHKLHLPEPLERFLLYQ 323
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 298 bits (763), Expect = 4e-81
Identities = 144/262 (54%), Positives = 192/262 (73%), Gaps = 1/262 (0%)
Query: 68 WADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGA 127
WADRSPLHEAA+QGRLLAL+TL++QG NVN VT++ V+ LHEACLG HVACA+ LLE GA
Sbjct: 42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 101
Query: 128 NVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDIL 187
+VN +T+ G TPLFNAC GS +C +LLE+GAKAQLE L SP HEA +GH EC++IL
Sbjct: 102 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 161
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTE 247
++ +++D E+P LGTPLYVAC Q+ C+ KLL GA V G++ DTPLHAAA+QS+ E
Sbjct: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVE 221
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGK 307
+++LL ++GA++ +N + +D+A S VE+ LL E P +L QLCRLC+R +G+
Sbjct: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG-PPALSQLCRLCVRKCLGR 280
Query: 308 PRLHLIPQLQLPTLLKNFLQYR 329
I +L LP L+ FL Y+
Sbjct: 281 ACHQAIHKLHLPEPLERFLLYQ 302
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 267 bits (683), Expect = 8e-72
Identities = 137/258 (53%), Positives = 179/258 (69%), Gaps = 1/258 (0%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
+D SP+HEAA G L+LR L+SQG+ VN +T DHV+PLHEACLG H++C + LL+ GA
Sbjct: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILI 188
VN +T D TPLFNAC GS C LLL++GA Q ES L SP HEAA +GH EC++ LI
Sbjct: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLI 154
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEI 248
++G ++D +I HLGTPLY+AC +QQ C+ KLL +GADV +GK D+PLHA A+ +S E+
Sbjct: 155 AYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEEL 214
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGKP 308
LL++FGAD AKN E RP+++ S + ++ L+ E P SL QLCRL IR G
Sbjct: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREG-PPSLMQLCRLRIRKCFGIQ 273
Query: 309 RLHLIPQLQLPTLLKNFL 326
+ H I +L LP LK FL
Sbjct: 274 QHHKITKLVLPEDLKQFL 291
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 241 bits (614), Expect = 8e-64
Identities = 117/219 (53%), Positives = 157/219 (71%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
+D SP+HEAA G L+LR L+SQG+ VN +T DHV+PLHEACLG H++C + LL+ GA
Sbjct: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILI 188
VN +T D TPLFNAC GS C LLL++GA Q ES L SP HEAA +GH EC++ LI
Sbjct: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLI 154
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEI 248
++G ++D +I HLGTPLY+AC +QQ C+ KLL +GADV +GK D+PLHA A+ +S E+
Sbjct: 155 AYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEEL 214
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHE 287
LL++FGAD AKN E RP+++ S + ++ L+ E
Sbjct: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLERE 253
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 207 bits (528), Expect = 8e-54
Identities = 110/263 (41%), Positives = 153/263 (58%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G W +R+P+HEAA +G L L+ L+ G VN VT+D +TPLH A L C + LL A
Sbjct: 15 GFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAA 74
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLD 185
GA V+A IDG TPL +AC+ GS C +LLL YGAK SP HEA G EC+
Sbjct: 75 GAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVR 134
Query: 186 ILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSS 245
+LI G +++ H GTPL+VAC + C+ LL AGA+V K +T LH AA+ +
Sbjct: 135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKN 194
Query: 246 TEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYI 305
+++ +L+EFG +I A++ +P D SSS + +E TP +L QLCR+ +R
Sbjct: 195 VDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKAT 254
Query: 306 GKPRLHLIPQLQLPTLLKNFLQY 328
G L I +L +P L ++L Y
Sbjct: 255 GVRGLEKIAKLNIPPRLIDYLSY 277
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 111 bits (278), Expect = 8e-25
Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL G + A T + ++P+H A GDH+ C R LL+ A ++
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
IT+D +TPL A G A++LL+ GAK + +P H A K H +++L+
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEI 248
G +D TPL+VA + LL GA +V K +TPLH AA+ TE+
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEV 485
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
LL+ A +NAK + P+ A + + ++LL++ A P+
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Score = 108 bits (269), Expect = 9e-24
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 4/221 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G ++ +R LL +G + T D +TPLH A HV + LL+ GA + A
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISW 190
T +G++P+ A C LLL+Y A+ + +P H AA GHH +L+
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G + + TPL++AC + LL GA + + TPLH A+ IV
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
LL+ GA N N ++ P+ +A + E + LLQ++A
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Score = 107 bits (268), Expect = 1e-23
Identities = 81/227 (35%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SP+H AA L +R LL ++ +TLDH+TPLH A H A+ LL+ GA N+
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL+ GA A ES L +P H A+ GH + L+
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 458
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + + TPL++A + LL A V K K TPLH AA+ T +
Sbjct: 459 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 518
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSSL 293
V LLLE A+ N T P+ +A VE + LL+ EA+ + +
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Score = 105 bits (261), Expect = 7e-23
Identities = 76/205 (37%), Positives = 106/205 (51%), Gaps = 4/205 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A L ++ LL +G + ++ + TPLH A + V AR+LL+ G + NA
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
++ GVTPL A +G LLL A L +S L +P H A +GH D+LI
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADVLIK 722
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G+ VD TPL+VA + LL ADV K K +PLH AAQQ T+I
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LLL+ GA N +++ P+ +A
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 102 bits (255), Expect = 4e-22
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA L + LL++G +VN + +TPLH A +V R LL+ GA +
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T D +TPL A G +E+LL++GA Q ++ SP H AA H +C+ +L+ +
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 191 GIDVDQ-EIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEI 248
++D + HL TPL+VA LL GA + TPLH A +++ +
Sbjct: 361 DAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
+ LLL+ GA I+A L P+ VA+ + + LLQ A+P+
Sbjct: 420 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Score = 95.1 bits (235), Expect = 7e-20
Identities = 81/250 (32%), Positives = 117/250 (46%), Gaps = 37/250 (14%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G+ +R L++ G NVNA + TPL+ A +H+ + LLE GAN N T
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS--------------------PTH 173
DG TPL A QG + L+ YG K ++ LP+ P
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVR--LPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 174 EAASK---------GHHECLDI---LISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
+ SK H+E L++ L++ G V+ + TPL++A + LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292
Query: 222 YAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE 280
GA ++ K K TPLH AA+ I +LL+ GA I AK L PI +A ++
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 281 --RILLQHEA 288
R+LLQ++A
Sbjct: 353 CVRLLLQYDA 362
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/231 (29%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G++ LL + + NA + +TPLH A +++ + LL G + ++
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A Q A LL+YG A ES +P H AA +GH E + +L+S
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS- 689
Query: 191 GIDVDQEIPHLG-----TPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQS 244
Q +LG TPL++ L+ G V + TPLH A+
Sbjct: 690 ----KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 745
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ ++V LL+ AD+NAK P+ A + +LL++ A+P+ +
Sbjct: 746 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 796
Score = 84.3 bits (207), Expect = 1e-16
Identities = 73/222 (32%), Positives = 100/222 (45%), Gaps = 6/222 (2%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH AA G ++ LL N N T TPLH A HV LLE A+
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDIL 187
+T G TPL A G AELLLE A A ++ L +P H A + + + +L
Sbjct: 563 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLL 621
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL-YAGADVQKGKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL Y G+ + TPLH AAQ+
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSS--MVERILLQH 286
E+V LLL A+ N N L P+ + V +L++H
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 4/224 (1%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
A +PLH AA +G + + LL + + +T TPLH A V A LLE A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDIL 187
NA +G+TPL A + +LLL G + +P H AA + E L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQSST 246
+ +G + E TPL++A + LL A+ G K TPLH AQ+
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+ ++L++ G ++A P+ VA+ ++ + LLQH+A
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/267 (27%), Positives = 111/267 (41%), Gaps = 33/267 (12%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTP------------ 106
YG S +PL+ AA + L ++ LL G N N T D TP
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 107 -----------------LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
LH A D A LL+ N + ++ G TPL A +
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252
Query: 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
+ A+LLL GA +P H A+ +G+ + +L+ G ++ + TPL+ A
Sbjct: 253 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 312
Query: 209 CMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL 267
+ LL GA +Q K K +P+H AAQ + V LLL++ A+I+ + L
Sbjct: 313 ARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
Query: 268 RPIDVAT--SSSMVERILLQHEATPSS 292
P+ VA V ++LL A P+S
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/248 (27%), Positives = 103/248 (41%), Gaps = 33/248 (13%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ +G + + LL + + T T LH A L R L+ GANVNA +
Sbjct: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
G TPL+ A + + LLE GA + + +P A +GH + LI++G
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 201
Query: 193 DVDQEIPHLG-----------------------------TPLYVACMSQQFHCIWKLLYA 223
+P L TPL++A + + LL
Sbjct: 202 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261
Query: 224 GADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSS--MVE 280
GA V + TPLH A+++ + +V LLL+ GA I K + L P+ A + +
Sbjct: 262 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
Query: 281 RILLQHEA 288
ILL H A
Sbjct: 322 EILLDHGA 329
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ E AR + YG + S +PLH AA +G + LLS+ N N +
Sbjct: 644 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH HV A L++ G V+A T G TPL A G+ + LL++ A
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 165 ESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
++ L SP H+AA +GH + + +L+ G ++ TPL +A
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G+ + +PLH A +G + L+ G V+A T TPLH A ++ + LL+
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECL 184
A+VNA T G +PL A QG LLL+ GA ++ S +P A G+
Sbjct: 757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 816
Query: 185 DIL 187
D+L
Sbjct: 817 DVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 111 bits (278), Expect = 8e-25
Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL G + A T + ++P+H A GDH+ C R LL+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
IT+D +TPL A G A++LL+ GAK + +P H A K H +++L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEI 248
G +D TPL+VA + LL GA +V K +TPLH AA+ TE+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEV 452
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
LL+ A +NAK + P+ A + + ++LL++ A P+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 108 bits (269), Expect = 9e-24
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 4/221 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G ++ +R LL +G + T D +TPLH A HV + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISW 190
T +G++P+ A C LLL+Y A+ + +P H AA GHH +L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G + + TPL++AC + LL GA + + TPLH A+ IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
LL+ GA N N ++ P+ +A + E + LLQ++A
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 107 bits (268), Expect = 1e-23
Identities = 81/227 (35%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SP+H AA L +R LL ++ +TLDH+TPLH A H A+ LL+ GA N+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL+ GA A ES L +P H A+ GH + L+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + + TPL++A + LL A V K K TPLH AA+ T +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSSL 293
V LLLE A+ N T P+ +A VE + LL+ EA+ + +
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Score = 105 bits (261), Expect = 7e-23
Identities = 76/205 (37%), Positives = 106/205 (51%), Gaps = 4/205 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A L ++ LL +G + ++ + TPLH A + V AR+LL+ G + NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
++ GVTPL A +G LLL A L +S L +P H A +GH D+LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADVLIK 689
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G+ VD TPL+VA + LL ADV K K +PLH AAQQ T+I
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LLL+ GA N +++ P+ +A
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 102 bits (255), Expect = 4e-22
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA L + LL++G +VN + +TPLH A +V R LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T D +TPL A G +E+LL++GA Q ++ SP H AA H +C+ +L+ +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 191 GIDVDQ-EIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEI 248
++D + HL TPL+VA LL GA + TPLH A +++ +
Sbjct: 328 DAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
+ LLL+ GA I+A L P+ VA+ + + LLQ A+P+
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Score = 95.1 bits (235), Expect = 7e-20
Identities = 81/250 (32%), Positives = 117/250 (46%), Gaps = 37/250 (14%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G+ +R L++ G NVNA + TPL+ A +H+ + LLE GAN N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS--------------------PTH 173
DG TPL A QG + L+ YG K ++ LP+ P
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVR--LPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 174 EAASK---------GHHECLDI---LISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
+ SK H+E L++ L++ G V+ + TPL++A + LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 222 YAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE 280
GA ++ K K TPLH AA+ I +LL+ GA I AK L PI +A ++
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 281 --RILLQHEA 288
R+LLQ++A
Sbjct: 320 CVRLLLQYDA 329
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/231 (29%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G++ LL + + NA + +TPLH A +++ + LL G + ++
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A Q A LL+YG A ES +P H AA +GH E + +L+S
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS- 656
Query: 191 GIDVDQEIPHLG-----TPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQS 244
Q +LG TPL++ L+ G V + TPLH A+
Sbjct: 657 ----KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ ++V LL+ AD+NAK P+ A + +LL++ A+P+ +
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
Score = 84.3 bits (207), Expect = 1e-16
Identities = 73/222 (32%), Positives = 100/222 (45%), Gaps = 6/222 (2%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH AA G ++ LL N N T TPLH A HV LLE A+
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDIL 187
+T G TPL A G AELLLE A A ++ L +P H A + + + +L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLL 588
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL-YAGADVQKGKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL Y G+ + TPLH AAQ+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSS--MVERILLQH 286
E+V LLL A+ N N L P+ + V +L++H
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 4/224 (1%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
A +PLH AA +G + + LL + + +T TPLH A V A LLE A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDIL 187
NA +G+TPL A + +LLL G + +P H AA + E L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQSST 246
+ +G + E TPL++A + LL A+ G K TPLH AQ+
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+ ++L++ G ++A P+ VA+ ++ + LLQH+A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/267 (27%), Positives = 111/267 (41%), Gaps = 33/267 (12%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTP------------ 106
YG S +PL+ AA + L ++ LL G N N T D TP
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 107 -----------------LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
LH A D A LL+ N + ++ G TPL A +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
+ A+LLL GA +P H A+ +G+ + +L+ G ++ + TPL+ A
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Query: 209 CMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL 267
+ LL GA +Q K K +P+H AAQ + V LLL++ A+I+ + L
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 268 RPIDVAT--SSSMVERILLQHEATPSS 292
P+ VA V ++LL A P+S
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/248 (27%), Positives = 103/248 (41%), Gaps = 33/248 (13%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ +G + + LL + + T T LH A L R L+ GANVNA +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
G TPL+ A + + LLE GA + + +P A +GH + LI++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 193 DVDQEIPHLG-----------------------------TPLYVACMSQQFHCIWKLLYA 223
+P L TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 224 GADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSS--MVE 280
GA V + TPLH A+++ + +V LLL+ GA I K + L P+ A + +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 281 RILLQHEA 288
ILL H A
Sbjct: 289 EILLDHGA 296
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ E AR + YG + S +PLH AA +G + LLS+ N N +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH HV A L++ G V+A T G TPL A G+ + LL++ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 165 ESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
++ L SP H+AA +GH + + +L+ G ++ TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G+ + +PLH A +G + L+ G V+A T TPLH A ++ + LL+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECL 184
A+VNA T G +PL A QG LLL+ GA ++ S +P A G+
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 185 DIL 187
D+L
Sbjct: 784 DVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 111 bits (278), Expect = 8e-25
Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL G + A T + ++P+H A GDH+ C R LL+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
IT+D +TPL A G A++LL+ GAK + +P H A K H +++L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEI 248
G +D TPL+VA + LL GA +V K +TPLH AA+ TE+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEV 452
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
LL+ A +NAK + P+ A + + ++LL++ A P+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 108 bits (269), Expect = 9e-24
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 4/221 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G ++ +R LL +G + T D +TPLH A HV + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISW 190
T +G++P+ A C LLL+Y A+ + +P H AA GHH +L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G + + TPL++AC + LL GA + + TPLH A+ IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
LL+ GA N N ++ P+ +A + E + LLQ++A
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 107 bits (268), Expect = 1e-23
Identities = 81/227 (35%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SP+H AA L +R LL ++ +TLDH+TPLH A H A+ LL+ GA N+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL+ GA A ES L +P H A+ GH + L+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + + TPL++A + LL A V K K TPLH AA+ T +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSSL 293
V LLLE A+ N T P+ +A VE + LL+ EA+ + +
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Score = 105 bits (261), Expect = 7e-23
Identities = 76/205 (37%), Positives = 106/205 (51%), Gaps = 4/205 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A L ++ LL +G + ++ + TPLH A + V AR+LL+ G + NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
++ GVTPL A +G LLL A L +S L +P H A +GH D+LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADVLIK 689
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G+ VD TPL+VA + LL ADV K K +PLH AAQQ T+I
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LLL+ GA N +++ P+ +A
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 102 bits (255), Expect = 4e-22
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA L + LL++G +VN + +TPLH A +V R LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T D +TPL A G +E+LL++GA Q ++ SP H AA H +C+ +L+ +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 191 GIDVDQ-EIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEI 248
++D + HL TPL+VA LL GA + TPLH A +++ +
Sbjct: 328 DAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
+ LLL+ GA I+A L P+ VA+ + + LLQ A+P+
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Score = 95.1 bits (235), Expect = 7e-20
Identities = 81/250 (32%), Positives = 117/250 (46%), Gaps = 37/250 (14%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G+ +R L++ G NVNA + TPL+ A +H+ + LLE GAN N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS--------------------PTH 173
DG TPL A QG + L+ YG K ++ LP+ P
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVR--LPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 174 EAASK---------GHHECLDI---LISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
+ SK H+E L++ L++ G V+ + TPL++A + LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 222 YAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE 280
GA ++ K K TPLH AA+ I +LL+ GA I AK L PI +A ++
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 281 --RILLQHEA 288
R+LLQ++A
Sbjct: 320 CVRLLLQYDA 329
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/231 (29%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G++ LL + + NA + +TPLH A +++ + LL G + ++
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A Q A LL+YG A ES +P H AA +GH E + +L+S
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS- 656
Query: 191 GIDVDQEIPHLG-----TPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQS 244
Q +LG TPL++ L+ G V + TPLH A+
Sbjct: 657 ----KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ ++V LL+ AD+NAK P+ A + +LL++ A+P+ +
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
Score = 84.3 bits (207), Expect = 1e-16
Identities = 73/222 (32%), Positives = 100/222 (45%), Gaps = 6/222 (2%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH AA G ++ LL N N T TPLH A HV LLE A+
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDIL 187
+T G TPL A G AELLLE A A ++ L +P H A + + + +L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLL 588
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL-YAGADVQKGKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL Y G+ + TPLH AAQ+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSS--MVERILLQH 286
E+V LLL A+ N N L P+ + V +L++H
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 4/224 (1%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
A +PLH AA +G + + LL + + +T TPLH A V A LLE A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDIL 187
NA +G+TPL A + +LLL G + +P H AA + E L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQSST 246
+ +G + E TPL++A + LL A+ G K TPLH AQ+
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+ ++L++ G ++A P+ VA+ ++ + LLQH+A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/267 (27%), Positives = 111/267 (41%), Gaps = 33/267 (12%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTP------------ 106
YG S +PL+ AA + L ++ LL G N N T D TP
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 107 -----------------LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
LH A D A LL+ N + ++ G TPL A +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
+ A+LLL GA +P H A+ +G+ + +L+ G ++ + TPL+ A
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Query: 209 CMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL 267
+ LL GA +Q K K +P+H AAQ + V LLL++ A+I+ + L
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 268 RPIDVAT--SSSMVERILLQHEATPSS 292
P+ VA V ++LL A P+S
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/248 (27%), Positives = 103/248 (41%), Gaps = 33/248 (13%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ +G + + LL + + T T LH A L R L+ GANVNA +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
G TPL+ A + + LLE GA + + +P A +GH + LI++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 193 DVDQEIPHLG-----------------------------TPLYVACMSQQFHCIWKLLYA 223
+P L TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 224 GADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSS--MVE 280
GA V + TPLH A+++ + +V LLL+ GA I K + L P+ A + +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 281 RILLQHEA 288
ILL H A
Sbjct: 289 EILLDHGA 296
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ E AR + YG + S +PLH AA +G + LLS+ N N +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH HV A L++ G V+A T G TPL A G+ + LL++ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 165 ESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
++ L SP H+AA +GH + + +L+ G ++ TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G+ + +PLH A +G + L+ G V+A T TPLH A ++ + LL+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECL 184
A+VNA T G +PL A QG LLL+ GA ++ S +P A G+
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 185 DIL 187
D+L
Sbjct: 784 DVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 111 bits (278), Expect = 8e-25
Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL G + A T + ++P+H A GDH+ C R LL+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
IT+D +TPL A G A++LL+ GAK + +P H A K H +++L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEI 248
G +D TPL+VA + LL GA +V K +TPLH AA+ TE+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEV 452
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
LL+ A +NAK + P+ A + + ++LL++ A P+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 108 bits (269), Expect = 9e-24
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 4/221 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G ++ +R LL +G + T D +TPLH A HV + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISW 190
T +G++P+ A C LLL+Y A+ + +P H AA GHH +L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G + + TPL++AC + LL GA + + TPLH A+ IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
LL+ GA N N ++ P+ +A + E + LLQ++A
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 107 bits (268), Expect = 1e-23
Identities = 81/227 (35%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SP+H AA L +R LL ++ +TLDH+TPLH A H A+ LL+ GA N+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL+ GA A ES L +P H A+ GH + L+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + + TPL++A + LL A V K K TPLH AA+ T +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSSL 293
V LLLE A+ N T P+ +A VE + LL+ EA+ + +
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Score = 105 bits (261), Expect = 7e-23
Identities = 76/205 (37%), Positives = 106/205 (51%), Gaps = 4/205 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A L ++ LL +G + ++ + TPLH A + V AR+LL+ G + NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
++ GVTPL A +G LLL A L +S L +P H A +GH D+LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADVLIK 689
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G+ VD TPL+VA + LL ADV K K +PLH AAQQ T+I
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LLL+ GA N +++ P+ +A
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 102 bits (255), Expect = 4e-22
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA L + LL++G +VN + +TPLH A +V R LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T D +TPL A G +E+LL++GA Q ++ SP H AA H +C+ +L+ +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 191 GIDVDQ-EIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEI 248
++D + HL TPL+VA LL GA + TPLH A +++ +
Sbjct: 328 DAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
+ LLL+ GA I+A L P+ VA+ + + LLQ A+P+
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Score = 95.1 bits (235), Expect = 7e-20
Identities = 81/250 (32%), Positives = 117/250 (46%), Gaps = 37/250 (14%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G+ +R L++ G NVNA + TPL+ A +H+ + LLE GAN N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS--------------------PTH 173
DG TPL A QG + L+ YG K ++ LP+ P
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVR--LPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 174 EAASK---------GHHECLDI---LISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
+ SK H+E L++ L++ G V+ + TPL++A + LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 222 YAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE 280
GA ++ K K TPLH AA+ I +LL+ GA I AK L PI +A ++
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 281 --RILLQHEA 288
R+LLQ++A
Sbjct: 320 CVRLLLQYDA 329
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/231 (29%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G++ LL + + NA + +TPLH A +++ + LL G + ++
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A Q A LL+YG A ES +P H AA +GH E + +L+S
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS- 656
Query: 191 GIDVDQEIPHLG-----TPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQS 244
Q +LG TPL++ L+ G V + TPLH A+
Sbjct: 657 ----KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ ++V LL+ AD+NAK P+ A + +LL++ A+P+ +
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
Score = 84.3 bits (207), Expect = 1e-16
Identities = 73/222 (32%), Positives = 100/222 (45%), Gaps = 6/222 (2%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH AA G ++ LL N N T TPLH A HV LLE A+
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDIL 187
+T G TPL A G AELLLE A A ++ L +P H A + + + +L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLL 588
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL-YAGADVQKGKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL Y G+ + TPLH AAQ+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSS--MVERILLQH 286
E+V LLL A+ N N L P+ + V +L++H
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 4/224 (1%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
A +PLH AA +G + + LL + + +T TPLH A V A LLE A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDIL 187
NA +G+TPL A + +LLL G + +P H AA + E L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQSST 246
+ +G + E TPL++A + LL A+ G K TPLH AQ+
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+ ++L++ G ++A P+ VA+ ++ + LLQH+A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/267 (27%), Positives = 111/267 (41%), Gaps = 33/267 (12%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTP------------ 106
YG S +PL+ AA + L ++ LL G N N T D TP
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 107 -----------------LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
LH A D A LL+ N + ++ G TPL A +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
+ A+LLL GA +P H A+ +G+ + +L+ G ++ + TPL+ A
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Query: 209 CMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL 267
+ LL GA +Q K K +P+H AAQ + V LLL++ A+I+ + L
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 268 RPIDVAT--SSSMVERILLQHEATPSS 292
P+ VA V ++LL A P+S
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/248 (27%), Positives = 103/248 (41%), Gaps = 33/248 (13%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ +G + + LL + + T T LH A L R L+ GANVNA +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
G TPL+ A + + LLE GA + + +P A +GH + LI++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 193 DVDQEIPHLG-----------------------------TPLYVACMSQQFHCIWKLLYA 223
+P L TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 224 GADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSS--MVE 280
GA V + TPLH A+++ + +V LLL+ GA I K + L P+ A + +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 281 RILLQHEA 288
ILL H A
Sbjct: 289 EILLDHGA 296
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ E AR + YG + S +PLH AA +G + LLS+ N N +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH HV A L++ G V+A T G TPL A G+ + LL++ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 165 ESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
++ L SP H+AA +GH + + +L+ G ++ TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G+ + +PLH A +G + L+ G V+A T TPLH A ++ + LL+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECL 184
A+VNA T G +PL A QG LLL+ GA ++ S +P A G+
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 185 DIL 187
D+L
Sbjct: 784 DVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 111 bits (278), Expect = 8e-25
Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL G + A T + ++P+H A GDH+ C R LL+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
IT+D +TPL A G A++LL+ GAK + +P H A K H +++L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEI 248
G +D TPL+VA + LL GA +V K +TPLH AA+ TE+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEV 452
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
LL+ A +NAK + P+ A + + ++LL++ A P+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 108 bits (269), Expect = 9e-24
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 4/221 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G ++ +R LL +G + T D +TPLH A HV + LL+ GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISW 190
T +G++P+ A C LLL+Y A+ + +P H AA GHH +L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G + + TPL++AC + LL GA + + TPLH A+ IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
LL+ GA N N ++ P+ +A + E + LLQ++A
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 107 bits (268), Expect = 1e-23
Identities = 81/227 (35%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SP+H AA L +R LL ++ +TLDH+TPLH A H A+ LL+ GA N+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL+ GA A ES L +P H A+ GH + L+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + + TPL++A + LL A V K K TPLH AA+ T +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSSL 293
V LLLE A+ N T P+ +A VE + LL+ EA+ + +
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Score = 105 bits (261), Expect = 7e-23
Identities = 76/205 (37%), Positives = 106/205 (51%), Gaps = 4/205 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A L ++ LL +G + ++ + TPLH A + V AR+LL+ G + NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
++ GVTPL A +G LLL A L +S L +P H A +GH D+LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADVLIK 689
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G+ VD TPL+VA + LL ADV K K +PLH AAQQ T+I
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LLL+ GA N +++ P+ +A
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 102 bits (255), Expect = 4e-22
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA L + LL++G +VN + +TPLH A +V R LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T D +TPL A G +E+LL++GA Q ++ SP H AA H +C+ +L+ +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 191 GIDVDQ-EIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEI 248
++D + HL TPL+VA LL GA + TPLH A +++ +
Sbjct: 328 DAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 249 VNLLLEFGADINAKNTELLRPIDVAT--SSSMVERILLQHEATPS 291
+ LLL+ GA I+A L P+ VA+ + + LLQ A+P+
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Score = 95.1 bits (235), Expect = 7e-20
Identities = 81/250 (32%), Positives = 117/250 (46%), Gaps = 37/250 (14%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G+ +R L++ G NVNA + TPL+ A +H+ + LLE GAN N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS--------------------PTH 173
DG TPL A QG + L+ YG K ++ LP+ P
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVR--LPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 174 EAASK---------GHHECLDI---LISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
+ SK H+E L++ L++ G V+ + TPL++A + LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 222 YAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE 280
GA ++ K K TPLH AA+ I +LL+ GA I AK L PI +A ++
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 281 --RILLQHEA 288
R+LLQ++A
Sbjct: 320 CVRLLLQYDA 329
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/231 (29%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G++ LL + + NA + +TPLH A +++ + LL G + ++
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A Q A LL+YG A ES +P H AA +GH E + +L+S
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS- 656
Query: 191 GIDVDQEIPHLG-----TPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQS 244
Q +LG TPL++ L+ G V + TPLH A+
Sbjct: 657 ----KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
Query: 245 STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ ++V LL+ AD+NAK P+ A + +LL++ A+P+ +
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
Score = 84.3 bits (207), Expect = 1e-16
Identities = 73/222 (32%), Positives = 100/222 (45%), Gaps = 6/222 (2%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH AA G ++ LL N N T TPLH A HV LLE A+
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDIL 187
+T G TPL A G AELLLE A A ++ L +P H A + + + +L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLL 588
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL-YAGADVQKGKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL Y G+ + TPLH AAQ+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSS--MVERILLQH 286
E+V LLL A+ N N L P+ + V +L++H
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 4/224 (1%)
Query: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
A +PLH AA +G + + LL + + +T TPLH A V A LLE A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDIL 187
NA +G+TPL A + +LLL G + +P H AA + E L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQQSST 246
+ +G + E TPL++A + LL A+ G K TPLH AQ+
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+ ++L++ G ++A P+ VA+ ++ + LLQH+A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/267 (27%), Positives = 111/267 (41%), Gaps = 33/267 (12%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTP------------ 106
YG S +PL+ AA + L ++ LL G N N T D TP
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 107 -----------------LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
LH A D A LL+ N + ++ G TPL A +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
+ A+LLL GA +P H A+ +G+ + +L+ G ++ + TPL+ A
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Query: 209 CMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL 267
+ LL GA +Q K K +P+H AAQ + V LLL++ A+I+ + L
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 268 RPIDVAT--SSSMVERILLQHEATPSS 292
P+ VA V ++LL A P+S
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/248 (27%), Positives = 103/248 (41%), Gaps = 33/248 (13%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ +G + + LL + + T T LH A L R L+ GANVNA +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
G TPL+ A + + LLE GA + + +P A +GH + LI++G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 193 DVDQEIPHLG-----------------------------TPLYVACMSQQFHCIWKLLYA 223
+P L TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 224 GADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSS--MVE 280
GA V + TPLH A+++ + +V LLL+ GA I K + L P+ A + +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 281 RILLQHEA 288
ILL H A
Sbjct: 289 EILLDHGA 296
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ E AR + YG + S +PLH AA +G + LLS+ N N +
Sbjct: 611 KQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH HV A L++ G V+A T G TPL A G+ + LL++ A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 165 ESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVA 208
++ L SP H+AA +GH + + +L+ G ++ TPL +A
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
G+ + +PLH A +G + L+ G V+A T TPLH A ++ + LL+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECL 184
A+VNA T G +PL A QG LLL+ GA ++ S +P A G+
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 185 DIL 187
D+L
Sbjct: 784 DVL 786
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 105 bits (261), Expect = 7e-23
Identities = 95/305 (31%), Positives = 123/305 (40%), Gaps = 50/305 (16%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AAS+G LR LL + ++ T LHEAC H AC LL AGA+ N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
DG PL G+ CAELLL +GA+ + E +P H AA GH E D+L+
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 190 WGIDVDQEIPHLGTPLYVAC-------------MSQQFHCIWKLLYAGADVQKG-KYWDT 235
G D TPL AC ++ LL AGAD +
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPID---------VATSSSMVERILLQH 286
PLH A ++ +V LLL G N + P+ +A S V R LL H
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
Query: 287 EAT------------------------PSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLL 322
A P SL L R +RS++ +P+L LP L
Sbjct: 402 GAVRVWPGALPKKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRL 461
Query: 323 KNFLQ 327
+LQ
Sbjct: 462 LRYLQ 466
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/135 (35%), Positives = 64/135 (47%), Gaps = 11/135 (8%)
Query: 165 ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAG 224
E L +P H AAS+GH E L +L+ D P T L+ AC + C+ LL AG
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 225 ADV----QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLR-PIDVATSSSMV 279
AD Q GK PLH + E LLL FGA ++ ++ E P+ VA V
Sbjct: 217 ADPNIADQDGK---RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273
Query: 280 E--RILLQHEATPSS 292
E +LL+ A P +
Sbjct: 274 ELADLLLRRGACPDA 288
Score = 47.4 bits (111), Expect = 2e-05
Identities = 44/154 (28%), Positives = 58/154 (37%), Gaps = 22/154 (14%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A + F G+ + +PLH AA G + LL +G +A + TPL
Sbjct: 240 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLA 299
Query: 110 AC------LGDHVA-------CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLL 156
AC + D A LL AGA+ +A D PL AC +G + ELLL
Sbjct: 300 ACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
Query: 157 ---------EYGAKAQLESCLPSPTHEAASKGHH 181
+YG L L P A H
Sbjct: 360 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
Score = 34.7 bits (78), Expect = 0.12
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 3/91 (3%)
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIV 249
W + ++E L TPL+VA + LL A T LH A T V
Sbjct: 153 WSLTYEEE---LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACV 209
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE 280
++LL GAD N + + RP+ + +E
Sbjct: 210 HVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 102 bits (254), Expect = 5e-22
Identities = 80/225 (35%), Positives = 109/225 (48%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPLH A L ++ LL V+ VT D++T LH A H A+ LL+ AN NA
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ--LESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELLL++GA Q ES L +P H AA GH + L+
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMH 454
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G + T L++A S Q + L+ GA V+ K K TPLH +A+ +I
Sbjct: 455 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 514
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSM--VERILLQHEATPS 291
V LL+ GA NA T P+ ++ V LL H A+ S
Sbjct: 515 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Score = 99.4 bits (246), Expect = 4e-21
Identities = 72/226 (31%), Positives = 110/226 (48%), Gaps = 4/226 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G+L LL + + +A +TPLH A D+ A LL+ GA+ +A
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+G TPL A + A LLEYGA A + + H AA +GH + + +L+
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
+V+ TPL++A + + L+ GA V + K TPLH + +IV
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746
Query: 250 NLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQHEATPSSL 293
N LL+ A +NAK P+ A + + +LLQ+ A+P+ L
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 92.8 bits (229), Expect = 4e-19
Identities = 70/226 (30%), Positives = 108/226 (47%), Gaps = 6/226 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G + LL++ V+ + +TPLH A + + LL+ GA ++A
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
T DG+TPL G E+LL+ A ++ ++ L SP H A H C+ +L+
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL-SPLHMATQGDHLNCVQLLLQ 355
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
+ VD T L+VA + LL A+ K TPLH A +++ ++
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERI--LLQHEATPSS 292
+ LLL+ GA I A L PI VA V + L+ H A+P++
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Score = 92.4 bits (228), Expect = 5e-19
Identities = 79/282 (28%), Positives = 120/282 (42%), Gaps = 16/282 (5%)
Query: 19 FTILSLFCFKLFVKISLAILSHFYIVKGNRKEAA---RIAAEF-----------YGVTQG 64
FT L + C K +K+ +L H ++ + +AA +G +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Query: 65 QGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLE 124
+ + LH AA G+ +R L+ G V A D TPLH + + LL+
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Query: 125 AGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHEC 183
GA+ NA T G TPL + +G A LL++GA + + +P H AA G E
Sbjct: 521 QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 580
Query: 184 LDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQ 242
++L+ D TPL+VA LL GA K TPLH AA+
Sbjct: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640
Query: 243 QSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
++ +I LLE+GAD NA + + + +A V+ + L
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSL 682
Score = 90.5 bits (223), Expect = 2e-18
Identities = 71/214 (33%), Positives = 107/214 (50%), Gaps = 7/214 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH A+ G+ ++ L++ G NVNA + + TPL+ A +H+ + LL+ GA+ + T
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT 170
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGID 193
DG TPL A QG LLLE K ++ LP+ H AA K + +L+ +
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTKGKVR--LPA-LHIAARKDDTKAAALLLQNDNN 227
Query: 194 VDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWD-TPLHAAAQQSSTEIVNLL 252
D E TPL++A + LL A V D TPLH A+++ + +V LL
Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287
Query: 253 LEFGADINAKNTELLRPIDVATSS---SMVERIL 283
L+ GA I+AK + L P+ S +VE +L
Sbjct: 288 LDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/213 (32%), Positives = 101/213 (47%), Gaps = 4/213 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D++PLH +A G+ ++ LL QG + NA T TPLH + H A LL+ GA++
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDIL 187
+ T G TPL A G A LLL+ A A +S L +P H AA + + +L
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-TPLHVAAHYDNQKVALLL 617
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSST 246
+ G + TPL++A Q LL GAD + +H AAQ+
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMV 279
++V+LLL A++N N L P+ +A V
Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 710
Score = 88.2 bits (217), Expect = 9e-18
Identities = 64/223 (28%), Positives = 106/223 (47%), Gaps = 4/223 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D +PLH A+ +G ++ LL +G ++A T D +TPLH H LL+ A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILI 188
+ T +G++PL A +C +LLL++ + + + H AA GH++ +L+
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTE 247
+ + + + TPL++AC + + LL GA +Q + TP+H AA
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
IV+ L+ GA N N + +A S E R L+Q A
Sbjct: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490
Score = 68.9 bits (167), Expect = 6e-12
Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 2/145 (1%)
Query: 45 KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHV 104
K N+ + A E YG + + +H AA +G + + LL + NVN +
Sbjct: 640 KKNQMDIATTLLE-YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 105 TPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
TPLH A D V A L+ GA+V+A T G TPL C G+ LL++ AK
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 165 ESCLP-SPTHEAASKGHHECLDILI 188
++ +P H+AA +GH +++L+
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLL 783
Score = 67.8 bits (164), Expect = 1e-11
Identities = 64/219 (29%), Positives = 97/219 (44%), Gaps = 8/219 (3%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PL+ AA + L ++ LL G + + T D TPL A H LLE
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
+ L A + A LLL+ A +ES +P H AA G+ +L++
Sbjct: 202 ----RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
VD + TPL+VA + + LL GA + K + TPLH A+ ++V
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQH 286
+LL+ A I +K L P+ +AT + ++LLQH
Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 58.5 bits (140), Expect = 8e-09
Identities = 54/198 (27%), Positives = 82/198 (41%), Gaps = 4/198 (2%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDG 136
AA G L + G ++N + + LH A HV LL+ ANV+A T G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 137 VTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVD 195
T L A G ++L+ GA +S +P + AA + H E + L+ G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 196 QEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEF 255
TPL VA + LL + KGK LH AA++ T+ LLL+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLL---ENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 256 GADINAKNTELLRPIDVA 273
+ + ++ P+ +A
Sbjct: 225 DNNADVESKSGFTPLHIA 242
Score = 45.8 bits (107), Expect = 5e-05
Identities = 28/84 (33%), Positives = 39/84 (46%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH G + + LL VNA T + TPLH+A H LL+ A+ N
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 132 ITIDGVTPLFNACSQGSPSCAELL 155
+T++G T L A G S + L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 101 bits (252), Expect = 8e-22
Identities = 79/225 (35%), Positives = 112/225 (49%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPLH AA + ++ LL V+ VTLD++T LH A H + LL+ AN NA
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ--LESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELL++YGA Q ES L +P H AA GH + +L+
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 431
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D T L++A + Q + LL GA V + + TPLH A++ TEI
Sbjct: 432 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 491
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPS 291
V LLL+ A +A T P+ ++ V+ +LL+ A S
Sbjct: 492 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Score = 100 bits (250), Expect = 1e-21
Identities = 76/193 (39%), Positives = 94/193 (48%), Gaps = 4/193 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA LL +G + +A + TPLH A + + A TLL GA N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
+T GVTPL A +G LLL+ GA + +S L S H AA + DIL
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 695
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D D TPL VAC + LL GA+V K K TPLH AAQQ T I
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755
Query: 249 VNLLLEFGADINA 261
+N+LL+ GA NA
Sbjct: 756 INVLLQHGAKPNA 768
Score = 95.9 bits (237), Expect = 4e-20
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 64 GQGSWAD------RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVA 117
G+GS D + LH A+ G+ ++ L+ +G N+NA + + TPL+ A +H+
Sbjct: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 123
Query: 118 CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAAS 177
+ LLE GAN + T DG TPL A QG +LLE K ++ LP+ H AA
Sbjct: 124 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR--LPA-LHIAAR 180
Query: 178 KGHHECLDILISWGIDVDQEIPHL--------GTPLYVACMSQQFHCIWKLLYAGADVQ- 228
K + +L+ + D + + TPL++A + LL GA V
Sbjct: 181 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 240
Query: 229 KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQH 286
+ TPLH A+++ +T +V LLL+ G I+AK + L P+ A S V +LL+
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
Query: 287 EATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
A L R+ G LH+ Q +K+ LQ++
Sbjct: 301 GAP---------LLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/225 (30%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G L + LL + ++ + +TPLH A D+ A LLE GA+ +A
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISW 190
+G TPL A + A LL YGA+ + + +P H A+ +GH + + +L+
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G ++ T L++A + + L GAD K TPL A + ++V
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723
Query: 250 NLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQHEATPSS 292
N LL+ GA++NAK P+ A + + +LLQH A P++
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Score = 90.1 bits (222), Expect = 2e-18
Identities = 76/260 (29%), Positives = 119/260 (45%), Gaps = 41/260 (15%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVT-------------------------- 105
+PLH A+ +G ++ LL +G ++A T D +T
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
Query: 106 -------PLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEY 158
PLH A GDHV C + LL+ A V+ +T+D +T L A G +LLL+
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366
Query: 159 GAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLG-TPLYVACMSQQFHC 216
A + +P H A K + +++L+ +G + Q I G TP++VA +
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMGHLNI 425
Query: 217 IWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVAT 274
+ LL GA DV + +T LH AA+ E+V LL GA ++A+ E P+ +A+
Sbjct: 426 VLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 484
Query: 275 SSSMVE--RILLQHEATPSS 292
E ++LLQH A P +
Sbjct: 485 RLGKTEIVQLLLQHMAHPDA 504
Score = 87.8 bits (216), Expect = 1e-17
Identities = 72/223 (32%), Positives = 105/223 (47%), Gaps = 4/223 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
+++PLH A+ G+ ++ LL + +A T + TPLH + V A LLEAGA
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILI 188
+ T G TPL A GS A+LLL+ A A +P H AA + + +L+
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTE 247
G + TPL++A Q LL GA+ K TPLH A+Q+ T+
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+V LLL+ GA+I+ L + +A V IL +H A
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 698
Score = 82.8 bits (203), Expect = 4e-16
Identities = 70/232 (30%), Positives = 105/232 (45%), Gaps = 9/232 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G++ +R LL G V+A + TPLH A + LL+ A+ +A T
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
+G TPL + +G A +LLE GA L + +P H AA G + +L+
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 193 DVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNL 251
D + TPL+VA LL GA K TPLH AA+++ +I +
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 626
Query: 252 LLEFGADINAKNTELLRPIDVATSSSMVERILLQ-------HEATPSSLYQL 296
LL +GA+ N + + P+ +A+ + + L H +T S L L
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/204 (28%), Positives = 93/204 (45%), Gaps = 3/204 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G + LL +G N++ T +T LH A D V A L + GA+ +A
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T G TPL AC G+ LL+ GA ++ +P H+AA +GH +++L+
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA-AQQSSTEIV 249
G + + T L +A + L +V T H ++ TE++
Sbjct: 763 GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 822
Query: 250 NLLLEFGAD-INAKNTELLRPIDV 272
++ E G D + E LRP D+
Sbjct: 823 DVSDEEGDDTMTGDGGEYLRPEDL 846
Score = 56.6 bits (135), Expect = 3e-08
Identities = 53/189 (28%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDG 136
AA G L + L G ++N + + LH A HV + LL G++V++ T G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 137 VTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVD 195
T L A G ++L++ GA +S +P + AA + H + + L+ G +
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 196 QEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLL-- 253
TPL VA + LL + KGK LH AA++ T+ LLL
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILL---ENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 254 EFGADINAK 262
+ AD+ +K
Sbjct: 194 DHNADVQSK 202
Score = 51.6 bits (122), Expect = 9e-07
Identities = 35/97 (36%), Positives = 45/97 (46%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVAC 118
+G Q + +PL A G + + LL QG NVNA T + TPLH+A H
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755
Query: 119 ARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL 155
LL+ GA NA T +G T L A G S + L
Sbjct: 756 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 101 bits (252), Expect = 8e-22
Identities = 79/225 (35%), Positives = 112/225 (49%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPLH AA + ++ LL V+ VTLD++T LH A H + LL+ AN NA
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ--LESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELL++YGA Q ES L +P H AA GH + +L+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 452
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D T L++A + Q + LL GA V + + TPLH A++ TEI
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPS 291
V LLL+ A +A T P+ ++ V+ +LL+ A S
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 100 bits (250), Expect = 1e-21
Identities = 76/193 (39%), Positives = 94/193 (48%), Gaps = 4/193 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA LL +G + +A + TPLH A + + A TLL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
+T GVTPL A +G LLL+ GA + +S L S H AA + DIL
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 716
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D D TPL VAC + LL GA+V K K TPLH AAQQ T I
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 249 VNLLLEFGADINA 261
+N+LL+ GA NA
Sbjct: 777 INVLLQHGAKPNA 789
Score = 95.9 bits (237), Expect = 4e-20
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 64 GQGSWAD------RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVA 117
G+GS D + LH A+ G+ ++ L+ +G N+NA + + TPL+ A +H+
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 144
Query: 118 CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAAS 177
+ LLE GAN + T DG TPL A QG +LLE K ++ LP+ H AA
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR--LPA-LHIAAR 201
Query: 178 KGHHECLDILISWGIDVDQEIPHL--------GTPLYVACMSQQFHCIWKLLYAGADVQ- 228
K + +L+ + D + + TPL++A + LL GA V
Sbjct: 202 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Query: 229 KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQH 286
+ TPLH A+++ +T +V LLL+ G I+AK + L P+ A S V +LL+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 287 EATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
A L R+ G LH+ Q +K+ LQ++
Sbjct: 322 GAP---------LLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/225 (30%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G L + LL + ++ + +TPLH A D+ A LLE GA+ +A
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISW 190
+G TPL A + A LL YGA+ + + +P H A+ +GH + + +L+
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G ++ T L++A + + L GAD K TPL A + ++V
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 250 NLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQHEATPSS 292
N LL+ GA++NAK P+ A + + +LLQH A P++
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Score = 90.1 bits (222), Expect = 2e-18
Identities = 76/260 (29%), Positives = 119/260 (45%), Gaps = 41/260 (15%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVT-------------------------- 105
+PLH A+ +G ++ LL +G ++A T D +T
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 106 -------PLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEY 158
PLH A GDHV C + LL+ A V+ +T+D +T L A G +LLL+
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 159 GAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLG-TPLYVACMSQQFHC 216
A + +P H A K + +++L+ +G + Q I G TP++VA +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMGHLNI 446
Query: 217 IWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVAT 274
+ LL GA DV + +T LH AA+ E+V LL GA ++A+ E P+ +A+
Sbjct: 447 VLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 275 SSSMVE--RILLQHEATPSS 292
E ++LLQH A P +
Sbjct: 506 RLGKTEIVQLLLQHMAHPDA 525
Score = 87.8 bits (216), Expect = 1e-17
Identities = 72/223 (32%), Positives = 105/223 (47%), Gaps = 4/223 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
+++PLH A+ G+ ++ LL + +A T + TPLH + V A LLEAGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILI 188
+ T G TPL A GS A+LLL+ A A +P H AA + + +L+
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTE 247
G + TPL++A Q LL GA+ K TPLH A+Q+ T+
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+V LLL+ GA+I+ L + +A V IL +H A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Score = 82.8 bits (203), Expect = 4e-16
Identities = 70/232 (30%), Positives = 105/232 (45%), Gaps = 9/232 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G++ +R LL G V+A + TPLH A + LL+ A+ +A T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
+G TPL + +G A +LLE GA L + +P H AA G + +L+
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 193 DVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNL 251
D + TPL+VA LL GA K TPLH AA+++ +I +
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 252 LLEFGADINAKNTELLRPIDVATSSSMVERILLQ-------HEATPSSLYQL 296
LL +GA+ N + + P+ +A+ + + L H +T S L L
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/204 (28%), Positives = 93/204 (45%), Gaps = 3/204 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G + LL +G N++ T +T LH A D V A L + GA+ +A
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T G TPL AC G+ LL+ GA ++ +P H+AA +GH +++L+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA-AQQSSTEIV 249
G + + T L +A + L +V T H ++ TE++
Sbjct: 784 GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 843
Query: 250 NLLLEFGAD-INAKNTELLRPIDV 272
++ E G D + E LRP D+
Sbjct: 844 DVSDEEGDDTMTGDGGEYLRPEDL 867
Score = 56.6 bits (135), Expect = 3e-08
Identities = 53/189 (28%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDG 136
AA G L + L G ++N + + LH A HV + LL G++V++ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 137 VTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVD 195
T L A G ++L++ GA +S +P + AA + H + + L+ G +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 196 QEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLL-- 253
TPL VA + LL + KGK LH AA++ T+ LLL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL---ENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 254 EFGADINAK 262
+ AD+ +K
Sbjct: 215 DHNADVQSK 223
Score = 51.6 bits (122), Expect = 9e-07
Identities = 35/97 (36%), Positives = 45/97 (46%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVAC 118
+G Q + +PL A G + + LL QG NVNA T + TPLH+A H
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 119 ARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL 155
LL+ GA NA T +G T L A G S + L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 101 bits (252), Expect = 8e-22
Identities = 79/225 (35%), Positives = 112/225 (49%), Gaps = 6/225 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPLH AA + ++ LL V+ VTLD++T LH A H + LL+ AN NA
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ--LESCLPSPTHEAASKGHHECLDILIS 189
++G TPL AC + ELL++YGA Q ES L +P H AA GH + +L+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 452
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D T L++A + Q + LL GA V + + TPLH A++ TEI
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPS 291
V LLL+ A +A T P+ ++ V+ +LL+ A S
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 100 bits (250), Expect = 1e-21
Identities = 76/193 (39%), Positives = 94/193 (48%), Gaps = 4/193 (2%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA LL +G + +A + TPLH A + + A TLL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL--ESCLPSPTHEAASKGHHECLDILIS 189
+T GVTPL A +G LLL+ GA + +S L S H AA + DIL
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 716
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G D D TPL VAC + LL GA+V K K TPLH AAQQ T I
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 249 VNLLLEFGADINA 261
+N+LL+ GA NA
Sbjct: 777 INVLLQHGAKPNA 789
Score = 95.9 bits (237), Expect = 4e-20
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 64 GQGSWAD------RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVA 117
G+GS D + LH A+ G+ ++ L+ +G N+NA + + TPL+ A +H+
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 144
Query: 118 CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAAS 177
+ LLE GAN + T DG TPL A QG +LLE K ++ LP+ H AA
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR--LPA-LHIAAR 201
Query: 178 KGHHECLDILISWGIDVDQEIPHL--------GTPLYVACMSQQFHCIWKLLYAGADVQ- 228
K + +L+ + D + + TPL++A + LL GA V
Sbjct: 202 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Query: 229 KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQH 286
+ TPLH A+++ +T +V LLL+ G I+AK + L P+ A S V +LL+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 287 EATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
A L R+ G LH+ Q +K+ LQ++
Sbjct: 322 GAP---------LLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/225 (30%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G L + LL + ++ + +TPLH A D+ A LLE GA+ +A
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISW 190
+G TPL A + A LL YGA+ + + +P H A+ +GH + + +L+
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G ++ T L++A + + L GAD K TPL A + ++V
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 250 NLLLEFGADINAKNTELLRPIDVATSS--SMVERILLQHEATPSS 292
N LL+ GA++NAK P+ A + + +LLQH A P++
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Score = 90.1 bits (222), Expect = 2e-18
Identities = 76/260 (29%), Positives = 119/260 (45%), Gaps = 41/260 (15%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVT-------------------------- 105
+PLH A+ +G ++ LL +G ++A T D +T
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 106 -------PLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEY 158
PLH A GDHV C + LL+ A V+ +T+D +T L A G +LLL+
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 159 GAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDQEIPHLG-TPLYVACMSQQFHC 216
A + +P H A K + +++L+ +G + Q I G TP++VA +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMGHLNI 446
Query: 217 IWKLLYAGA--DVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVAT 274
+ LL GA DV + +T LH AA+ E+V LL GA ++A+ E P+ +A+
Sbjct: 447 VLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 275 SSSMVE--RILLQHEATPSS 292
E ++LLQH A P +
Sbjct: 506 RLGKTEIVQLLLQHMAHPDA 525
Score = 87.8 bits (216), Expect = 1e-17
Identities = 72/223 (32%), Positives = 105/223 (47%), Gaps = 4/223 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
+++PLH A+ G+ ++ LL + +A T + TPLH + V A LLEAGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILI 188
+ T G TPL A GS A+LLL+ A A +P H AA + + +L+
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTE 247
G + TPL++A Q LL GA+ K TPLH A+Q+ T+
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
+V LLL+ GA+I+ L + +A V IL +H A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Score = 82.8 bits (203), Expect = 4e-16
Identities = 70/232 (30%), Positives = 105/232 (45%), Gaps = 9/232 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G++ +R LL G V+A + TPLH A + LL+ A+ +A T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
+G TPL + +G A +LLE GA L + +P H AA G + +L+
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 193 DVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNL 251
D + TPL+VA LL GA K TPLH AA+++ +I +
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 252 LLEFGADINAKNTELLRPIDVATSSSMVERILLQ-------HEATPSSLYQL 296
LL +GA+ N + + P+ +A+ + + L H +T S L L
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/204 (28%), Positives = 93/204 (45%), Gaps = 3/204 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A+ +G + LL +G N++ T +T LH A D V A L + GA+ +A
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISW 190
T G TPL AC G+ LL+ GA ++ +P H+AA +GH +++L+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA-AQQSSTEIV 249
G + + T L +A + L +V T H ++ TE++
Sbjct: 784 GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 843
Query: 250 NLLLEFGAD-INAKNTELLRPIDV 272
++ E G D + E LRP D+
Sbjct: 844 DVSDEEGDDTMTGDGGEYLRPEDL 867
Score = 56.6 bits (135), Expect = 3e-08
Identities = 53/189 (28%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDG 136
AA G L + L G ++N + + LH A HV + LL G++V++ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 137 VTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVD 195
T L A G ++L++ GA +S +P + AA + H + + L+ G +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 196 QEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLL-- 253
TPL VA + LL + KGK LH AA++ T+ LLL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL---ENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 254 EFGADINAK 262
+ AD+ +K
Sbjct: 215 DHNADVQSK 223
Score = 51.6 bits (122), Expect = 9e-07
Identities = 35/97 (36%), Positives = 45/97 (46%)
Query: 59 YGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVAC 118
+G Q + +PL A G + + LL QG NVNA T + TPLH+A H
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 119 ARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL 155
LL+ GA NA T +G T L A G S + L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 95.9 bits (237), Expect = 4e-20
Identities = 81/242 (33%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AAS+G LR LL + ++ T LHEAC H AC LL AGA+ N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
DG PL G+ CAELLL +GA+ + E +P H AA GH E D+L+
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 190 WGIDVDQEIPHLGTPLYVAC-------------MSQQFHCIWKLLYAGADVQKG-KYWDT 235
G D TPL AC ++ LL AGAD +
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPID---------VATSSSMVERILLQH 286
PLH A ++ +V LLL G N + P+ +A S V R LL H
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
Query: 287 EA 288
A
Sbjct: 402 GA 403
Score = 66.2 bits (160), Expect = 4e-11
Identities = 81/311 (26%), Positives = 115/311 (36%), Gaps = 54/311 (17%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN 130
R+ LHEA + G + LL G + N D PLH + CA LL GA V+
Sbjct: 194 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 253
Query: 131 AIT-IDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--------------CLPSPTHEA 175
+ + TPL A G A+LLL GA + C EA
Sbjct: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 313
Query: 176 ASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKY-WD 234
+ + +L+S G D D PL++AC + LL G Y
Sbjct: 314 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373
Query: 235 TPLHAAAQ-------QSSTEIVNLLLEFGA---------DINAKNTELLRPIDVATSSSM 278
TPLH A Q QS +V LL GA + + + R I+V ++
Sbjct: 374 TPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYS 433
Query: 279 VERI------------LLQHE----------ATPSSLYQLCRLCIRSYIGKPRLHLIPQL 316
V ++ L +H+ P SL L R +RS++ +P+L
Sbjct: 434 VVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRL 493
Query: 317 QLPTLLKNFLQ 327
LP L +LQ
Sbjct: 494 PLPPRLLRYLQ 504
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/135 (35%), Positives = 64/135 (47%), Gaps = 11/135 (8%)
Query: 165 ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAG 224
E L +P H AAS+GH E L +L+ D P T L+ AC + C+ LL AG
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 225 ADV----QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLR-PIDVATSSSMV 279
AD Q GK PLH + E LLL FGA ++ ++ E P+ VA V
Sbjct: 217 ADPNIADQDGK---RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273
Query: 280 E--RILLQHEATPSS 292
E +LL+ A P +
Sbjct: 274 ELADLLLRRGACPDA 288
Score = 47.4 bits (111), Expect = 2e-05
Identities = 44/154 (28%), Positives = 58/154 (37%), Gaps = 22/154 (14%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A + F G+ + +PLH AA G + LL +G +A + TPL
Sbjct: 240 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLA 299
Query: 110 AC------LGDHVA-------CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLL 156
AC + D A LL AGA+ +A D PL AC +G + ELLL
Sbjct: 300 ACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
Query: 157 ---------EYGAKAQLESCLPSPTHEAASKGHH 181
+YG L L P A H
Sbjct: 360 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
Score = 34.7 bits (78), Expect = 0.12
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 3/91 (3%)
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIV 249
W + ++E L TPL+VA + LL A T LH A T V
Sbjct: 153 WSLTYEEE---LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACV 209
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE 280
++LL GAD N + + RP+ + +E
Sbjct: 210 HVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 95.9 bits (237), Expect = 4e-20
Identities = 81/242 (33%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AAS+G LR LL + ++ T LHEAC H AC LL AGA+ N
Sbjct: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAK--AQLESCLPSPTHEAASKGHHECLDILIS 189
DG PL G+ CAELLL +GA+ + E +P H AA GH E D+L+
Sbjct: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
Query: 190 WGIDVDQEIPHLGTPLYVAC-------------MSQQFHCIWKLLYAGADVQKG-KYWDT 235
G D TPL AC ++ LL AGAD +
Sbjct: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
Query: 236 PLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPID---------VATSSSMVERILLQH 286
PLH A ++ +V LLL G N + P+ +A S V R LL H
Sbjct: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
Query: 287 EA 288
A
Sbjct: 342 GA 343
Score = 66.2 bits (160), Expect = 4e-11
Identities = 81/311 (26%), Positives = 115/311 (36%), Gaps = 54/311 (17%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN 130
R+ LHEA + G + LL G + N D PLH + CA LL GA V+
Sbjct: 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 193
Query: 131 AIT-IDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--------------CLPSPTHEA 175
+ + TPL A G A+LLL GA + C EA
Sbjct: 194 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 253
Query: 176 ASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKY-WD 234
+ + +L+S G D D PL++AC + LL G Y
Sbjct: 254 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
Query: 235 TPLHAAAQ-------QSSTEIVNLLLEFGA---------DINAKNTELLRPIDVATSSSM 278
TPLH A Q QS +V LL GA + + + R I+V ++
Sbjct: 314 TPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYS 373
Query: 279 VERI------------LLQHE----------ATPSSLYQLCRLCIRSYIGKPRLHLIPQL 316
V ++ L +H+ P SL L R +RS++ +P+L
Sbjct: 374 VVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRL 433
Query: 317 QLPTLLKNFLQ 327
LP L +LQ
Sbjct: 434 PLPPRLLRYLQ 444
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/135 (35%), Positives = 64/135 (47%), Gaps = 11/135 (8%)
Query: 165 ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAG 224
E L +P H AAS+GH E L +L+ D P T L+ AC + C+ LL AG
Sbjct: 98 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 156
Query: 225 ADV----QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLR-PIDVATSSSMV 279
AD Q GK PLH + E LLL FGA ++ ++ E P+ VA V
Sbjct: 157 ADPNIADQDGK---RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 213
Query: 280 E--RILLQHEATPSS 292
E +LL+ A P +
Sbjct: 214 ELADLLLRRGACPDA 228
Score = 47.4 bits (111), Expect = 2e-05
Identities = 44/154 (28%), Positives = 58/154 (37%), Gaps = 22/154 (14%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A + F G+ + +PLH AA G + LL +G +A + TPL
Sbjct: 180 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLA 239
Query: 110 AC------LGDHVA-------CARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLL 156
AC + D A LL AGA+ +A D PL AC +G + ELLL
Sbjct: 240 ACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 299
Query: 157 ---------EYGAKAQLESCLPSPTHEAASKGHH 181
+YG L L P A H
Sbjct: 300 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 333
Score = 34.7 bits (78), Expect = 0.12
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 3/91 (3%)
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIV 249
W + ++E L TPL+VA + LL A T LH A T V
Sbjct: 93 WSLTYEEE---LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACV 149
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVE 280
++LL GAD N + + RP+ + +E
Sbjct: 150 HVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 95.5 bits (236), Expect = 6e-20
Identities = 68/185 (36%), Positives = 94/185 (50%), Gaps = 5/185 (2%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN-AI 132
LH AASQG ++ LL G + NA TL+ TPL A + R LL+ GANVN +
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
Query: 133 TIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWG 191
++ G L A Q + +LLL GA + + +P AA G E L ILIS G
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ---KGKYWDTPLHAAAQQSSTEI 248
+V+ + TPL++A C+ LL +GAD W P+HAAAQ T+I
Sbjct: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 189
Query: 249 VNLLL 253
++LL+
Sbjct: 190 LDLLI 194
Score = 82.8 bits (203), Expect = 4e-16
Identities = 70/229 (30%), Positives = 100/229 (43%), Gaps = 9/229 (3%)
Query: 41 FYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVT 100
F V+ + + R+ + G S + LH+A+ Q ++ LL +G N
Sbjct: 44 FLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD 103
Query: 101 LDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA 160
+TPL A + L+ +GANVN +D TPLF A +G C ELLL GA
Sbjct: 104 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 163
Query: 161 KAQL---ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCI 217
L E P H AA GH + LD+LI + +P+Y A C+
Sbjct: 164 DPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL 223
Query: 218 WKLLYAG--ADVQKGKY--WDTPLHAAAQQSST--EIVNLLLEFGADIN 260
LL G D Q + +P+ A Q+ IVN+LL++GA IN
Sbjct: 224 EILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
Score = 68.6 bits (166), Expect = 7e-12
Identities = 93/352 (26%), Positives = 135/352 (38%), Gaps = 89/352 (25%)
Query: 48 RKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPL 107
RK A + + +G+T PL AA G+L +L L+S G NVN LD TPL
Sbjct: 94 RKGANKECQDDFGIT----------PLFVAAQYGKLESLSILISSGANVNCQALDKATPL 143
Query: 108 HEACLGDHVACARTLLEAGANVNAIT---------------------------------- 133
A H C LL +GA+ +
Sbjct: 144 FIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 203
Query: 134 -IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL----PSPTHEAASKG--HHECLDI 186
++ V+P+++A G C E+LL G ++CL SP A K ++I
Sbjct: 204 GLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNI 263
Query: 187 LISWGIDVDQEIPHLGTPLYVA-CMSQQFHCIWK-LLYAGADVQKGKY-WDTPLHAA-AQ 242
L+ +G +++ L++A C+ + I++ L G + + ++ HA AQ
Sbjct: 264 LLKYGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQ 315
Query: 243 QSSTEIVNLLLEFGAD---------------------INAKNTELLRPIDVATSSSMVER 281
E + LL G D + N + L P S+
Sbjct: 316 AKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASN 375
Query: 282 --ILLQHEATPSSLYQLCRLCIRSYIGKPRLH---LIPQLQLPTLLKNFLQY 328
IL QH AT SL LCRL IRS + RL I QL LP L N+L Y
Sbjct: 376 AWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLY 427
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/194 (26%), Positives = 78/194 (40%), Gaps = 34/194 (17%)
Query: 100 TLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYG 159
T + LH A H + LLEAGA+ NA T++ TPLF A G LLL++G
Sbjct: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
Query: 160 AKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWK 219
A G H + W L+ A + I
Sbjct: 63 ANVN---------------GSHS----MCGWN------------SLHQASFQENAEIIKL 91
Query: 220 LLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSM 278
LL GA+ + + + TPL AAQ E +++L+ GA++N + + P+ +A
Sbjct: 92 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 151
Query: 279 VE--RILLQHEATP 290
+ +LL A P
Sbjct: 152 TKCVELLLSSGADP 165
Score = 46.2 bits (108), Expect = 4e-05
Identities = 25/63 (39%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Query: 237 LHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEATPSSLY 294
LH AA Q +IV +LLE GAD NA E P+ +A + ++ R+LLQH A + +
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
Query: 295 QLC 297
+C
Sbjct: 70 SMC 72
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 95.5 bits (236), Expect = 6e-20
Identities = 68/185 (36%), Positives = 94/185 (50%), Gaps = 5/185 (2%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN-AI 132
LH AASQG ++ LL G + NA TL+ TPL A + R LL+ GANVN +
Sbjct: 83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 142
Query: 133 TIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWG 191
++ G L A Q + +LLL GA + + +P AA G E L ILIS G
Sbjct: 143 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 202
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ---KGKYWDTPLHAAAQQSSTEI 248
+V+ + TPL++A C+ LL +GAD W P+HAAAQ T+I
Sbjct: 203 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 262
Query: 249 VNLLL 253
++LL+
Sbjct: 263 LDLLI 267
Score = 82.8 bits (203), Expect = 4e-16
Identities = 70/229 (30%), Positives = 100/229 (43%), Gaps = 9/229 (3%)
Query: 41 FYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVT 100
F V+ + + R+ + G S + LH+A+ Q ++ LL +G N
Sbjct: 117 FLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD 176
Query: 101 LDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA 160
+TPL A + L+ +GANVN +D TPLF A +G C ELLL GA
Sbjct: 177 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 161 KAQL---ESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCI 217
L E P H AA GH + LD+LI + +P+Y A C+
Sbjct: 237 DPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL 296
Query: 218 WKLLYAG--ADVQKGKY--WDTPLHAAAQQSST--EIVNLLLEFGADIN 260
LL G D Q + +P+ A Q+ IVN+LL++GA IN
Sbjct: 297 EILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
Score = 68.6 bits (166), Expect = 7e-12
Identities = 93/352 (26%), Positives = 135/352 (38%), Gaps = 89/352 (25%)
Query: 48 RKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPL 107
RK A + + +G+T PL AA G+L +L L+S G NVN LD TPL
Sbjct: 167 RKGANKECQDDFGIT----------PLFVAAQYGKLESLSILISSGANVNCQALDKATPL 216
Query: 108 HEACLGDHVACARTLLEAGANVNAIT---------------------------------- 133
A H C LL +GA+ +
Sbjct: 217 FIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276
Query: 134 -IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL----PSPTHEAASKG--HHECLDI 186
++ V+P+++A G C E+LL G ++CL SP A K ++I
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNI 336
Query: 187 LISWGIDVDQEIPHLGTPLYVA-CMSQQFHCIWK-LLYAGADVQKGKY-WDTPLHAA-AQ 242
L+ +G +++ L++A C+ + I++ L G + + ++ HA AQ
Sbjct: 337 LLKYGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQ 388
Query: 243 QSSTEIVNLLLEFGAD---------------------INAKNTELLRPIDVATSSSMVER 281
E + LL G D + N + L P S+
Sbjct: 389 AKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASN 448
Query: 282 --ILLQHEATPSSLYQLCRLCIRSYIGKPRLH---LIPQLQLPTLLKNFLQY 328
IL QH AT SL LCRL IRS + RL I QL LP L N+L Y
Sbjct: 449 AWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLY 500
Score = 52.4 bits (124), Expect = 6e-07
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 175 AASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ--KGKY 232
AA +G+ + L L+ G VD P++ A C+ L+ A + K K
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 233 WD--TPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
++ LH AA Q +IV +LLE GAD NA E P+ +A + ++ R+LLQH A
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
Query: 289 TPSSLYQLC 297
+ + +C
Sbjct: 137 NVNGSHSMC 145
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 95.1 bits (235), Expect = 7e-20
Identities = 75/227 (33%), Positives = 99/227 (43%), Gaps = 14/227 (6%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
LH AA G + L S G N N + TPLH A + + A+ L EAG NVN
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPS---PTHEAASKGHHECLDILISW 190
+G TPL A ++G E L E+G A L +C H A + E + L+S
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHG--ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G VD + H TPL+VAC + L A ++ KY TPLH AA ++V
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQL 296
L GA + A T+ D+A S QHE L +L
Sbjct: 627 RYLCLMGASVEALTTDGKTAEDLARSE--------QHEHVAGLLARL 665
Score = 41.6 bits (96), Expect = 0.001
Identities = 47/185 (25%), Positives = 74/185 (40%), Gaps = 37/185 (20%)
Query: 114 DHVACARTLLEAGAN--VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL------- 164
D+V + LL + +N VN G PL A G+ +LL++ G++ +
Sbjct: 355 DNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSN 414
Query: 165 ------------------ESCLP---------SPTHEAASKGHHECLDILISWGIDVDQE 197
E+ P H AA GH + +L S+G + + +
Sbjct: 415 AVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQ 474
Query: 198 IPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFG 256
TPL+ A + L AG +V K + +TPL A+ + +IV L E G
Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534
Query: 257 ADINA 261
AD+NA
Sbjct: 535 ADLNA 539
Score = 34.7 bits (78), Expect = 0.12
Identities = 27/84 (32%), Positives = 36/84 (42%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A G + + L N++ TPLH A + R L GA+V A
Sbjct: 579 TPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 132 ITIDGVTPLFNACSQGSPSCAELL 155
+T DG T A S+ A LL
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGLL 662
Score = 29.6 bits (65), Expect = 3.9
Identities = 25/100 (25%), Positives = 42/100 (42%), Gaps = 1/100 (1%)
Query: 175 AASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYW 233
AA G+ + L +LI G +D + +Y A + L + K K
Sbjct: 386 AAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSG 445
Query: 234 DTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVA 273
+ LH AA+ ++ LL FG++ N ++ E P+ A
Sbjct: 446 EMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 95.1 bits (235), Expect = 7e-20
Identities = 73/220 (33%), Positives = 105/220 (47%), Gaps = 3/220 (1%)
Query: 60 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVA-C 118
GV + + +PLH A G+ + + L+ G VN TPLH A H A C
Sbjct: 229 GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 288
Query: 119 ARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAAS 177
L+ GA+VN + DG TPL G S ++ +++ GA E +P H AA
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 178 KGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTP 236
GH ++ LI+ G D + H PL++A +S C KLL +G D+ + T
Sbjct: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 237 LHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSS 276
LHAAA + E +NLLL GAD N K+ P+ A ++
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
Score = 94.4 bits (233), Expect = 1e-19
Identities = 68/208 (32%), Positives = 97/208 (46%), Gaps = 2/208 (0%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH A + A++ LL +VNA + TPLH A V CA L+ +NVN
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISW 190
G T L +A G +LLL GA + H AA GH E + +L+S
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIV 249
G +V + TPL+ A S + LL G D+ + Y +TPLH A +V
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 255
Query: 250 NLLLEFGADINAKNTELLRPIDVATSSS 277
N L++ GA +N KN + P+ A +S+
Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAAAST 283
Score = 88.2 bits (217), Expect = 9e-18
Identities = 62/210 (29%), Positives = 100/210 (47%), Gaps = 3/210 (1%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
DR +H AA G + ++ L+S G V TPLH A ++ + LL+ G ++
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHE-CLDIL 187
N G TPL AC G L++ GA Q +P H AA+ H CL++L
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSST 246
+ G DV+ + TPL++ + +F ++ +GA + + K +TPLH AA+
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSS 276
++N L+ GAD + + P+ +A S
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALS 382
Score = 84.3 bits (207), Expect = 1e-16
Identities = 64/205 (31%), Positives = 94/205 (45%), Gaps = 2/205 (0%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN 130
R+PLH AA G + L+ G VNA +TPLH A + LL+ A+VN
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 131 AITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL-ESCLPSPTHEAASKGHHECLDILIS 189
A + TPL A + + CAE L+ + + + + H AA GH E + +L+S
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEI 248
G +++ ++ A + L+ GA+V K K TPLHAAA +
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221
Query: 249 VNLLLEFGADINAKNTELLRPIDVA 273
V LL+ G D+N N P+ VA
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/235 (30%), Positives = 107/235 (45%), Gaps = 12/235 (5%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDH---VTPLHEACLGDHVACARTLLEAGA 127
R+P+H AA+ G LR L+ NAV + TPL + L H C +LL GA
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 128 NVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL-ESCLPSPTHEAASKGHHECLDI 186
NV+A G T L G C + LL++GAK L +S +P H +A+ GH L
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 737
Query: 187 LISWGIDVDQEIP----HLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQ 242
L+ +D H T L+ AC + C+ LL + +PLH A
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVI 797
Query: 243 QSSTEIVNLLLE-FGADI-NAKNTELLRPIDVATSSSMVE--RILLQHEATPSSL 293
+ +L++ GA I NA +++ P+ A + VE ++LL H A +S+
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/177 (30%), Positives = 85/177 (48%), Gaps = 10/177 (5%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN 130
++PLH A GR +T++ G ++ + TPLH A H TL+ +GA+
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 131 AITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL-----ESCLPSPTHEAASKGHHECLD 185
I G+ PL A G C LL G +CL H AA+ G+ ECL+
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCL----HAAAAGGNLECLN 422
Query: 186 ILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAA 241
+L++ G D +++ +PL+ A + + C++ L+ +GA V + TPLH AA
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Score = 72.4 bits (176), Expect = 5e-13
Identities = 66/232 (28%), Positives = 91/232 (39%), Gaps = 49/232 (21%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN 130
R+ LH AA+ G L L LL+ G + N +PLH A + C L+ +GA+VN
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 131 AITIDGVTPL-FNACSQGSPSCAELLL-----------------EYGAKAQLESCLP--- 169
+ G TPL + A S C E LL Y A CL
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
Query: 170 --------------------------SPTHEAASKGHHECLDILISWGIDVDQEIPHLGT 203
SP H AA GHH+ L++L+ +D+D T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 204 PLYVACMSQQFHCIWKLLYAGADVQKGKY--WDTPLHAAAQQSSTEIVNLLL 253
PL +A C+ L+ GA + Y TP+HAAA +E + LL+
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Score = 68.6 bits (166), Expect = 7e-12
Identities = 58/212 (27%), Positives = 94/212 (44%), Gaps = 2/212 (0%)
Query: 70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
D+ L +A G +R L+ + +VN + TPLH A L+ +GA V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL-ESCLPSPTHEAASKGHHECLDILI 188
NA +TPL A + S ++LL++ A + +P H AA+ +C + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWD-TPLHAAAQQSSTE 247
+V+ T L+ A S + LL GA++ D +H AA E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMV 279
+V LL+ GA++ K+ + P+ A SS M+
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMI 219
Score = 65.1 bits (157), Expect = 8e-11
Identities = 46/141 (32%), Positives = 67/141 (47%), Gaps = 1/141 (0%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PLH AA G L + TL++ G + + + PLH A L C R LL +G +++
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISW 190
G T L A + G+ C LLL GA + SP H AA+ +++CL L+
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGS 460
Query: 191 GIDVDQEIPHLGTPLYVACMS 211
G V+ TPL+ A S
Sbjct: 461 GASVNDLDERGCTPLHYAATS 481
Score = 62.8 bits (151), Expect = 4e-10
Identities = 53/164 (32%), Positives = 73/164 (44%), Gaps = 9/164 (5%)
Query: 72 SPLHEAASQGRLLALRTLLSQ--GYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
SPLH A A L+ VNA TPLH A DHV C + LL A V
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL---ESCLPSPTHEAASKGHHECLDI 186
N++ G TPL A G + E+L+ A A+L ++ + H A SKGH +
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVS-SASAELTLQDNSKNTALHLACSKGHETSALL 908
Query: 187 LISWGID---VDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
++ D ++ L TPL+VA + + +LL GA V
Sbjct: 909 ILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/173 (29%), Positives = 80/173 (46%), Gaps = 4/173 (2%)
Query: 120 RTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL-ESCLPSPTHEAASK 178
R L+ +VN + TPL A G ELL+ GA+ +S +P H A +
Sbjct: 25 RALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVAS 84
Query: 179 GHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPL 237
E + +L+ DV+ + TPL++A ++ C L+ ++V + T L
Sbjct: 85 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTAL 144
Query: 238 HAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
H AA E+V LLL GA+INA + + R I A +E ++L+ H A
Sbjct: 145 HHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Score = 34.3 bits (77), Expect = 0.16
Identities = 34/110 (30%), Positives = 47/110 (42%), Gaps = 6/110 (5%)
Query: 74 LHEAASQGR----LLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
LH A S+G LL L + + +NA TPLH A + LL GA+V
Sbjct: 894 LHLACSKGHETSALLILEKITDRNL-INATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Query: 130 NAITIDGVTP-LFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASK 178
A+ +G TP L A ++ C L+L S L S T A ++
Sbjct: 953 LAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINR 1002
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 95.1 bits (235), Expect = 7e-20
Identities = 75/238 (31%), Positives = 108/238 (45%), Gaps = 3/238 (1%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A++ + + +G D +PL AA+ G + ++ LL+ +VNA + T L
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 110 ACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--C 167
AC G +V + LLE+GA++ +G TPL A S G A LLLE GA S
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 168 LPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
S A KGH E + L+ G D + + + T L ACM LL +GA V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 228 -QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
+++PL AA E+ LL+E GA + N E P+ A E + L
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/166 (35%), Positives = 83/166 (50%), Gaps = 5/166 (3%)
Query: 102 DHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA- 160
+H T L AC G H +TLLE GA++ G TPL A + G E+LL+ GA
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
Query: 161 -KAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWK 219
+AQ E +P A S G E +++L++ G + + TPL +A + I
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 220 LLYAGADVQK---GKYWDTPLHAAAQQSSTEIVNLLLEFGADINAK 262
LL AGA++ K +PL AA T V LLL+ G+DINA+
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
Score = 82.4 bits (202), Expect = 5e-16
Identities = 78/284 (27%), Positives = 130/284 (45%), Gaps = 25/284 (8%)
Query: 46 GNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDH-- 103
G R+E + G + + +D +PL AAS G + ++ LL+ G +N+ T
Sbjct: 1160 GGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218
Query: 104 VTPLHEACLGDHVACARTLLEAGANVNA-ITIDGVTPLFNACSQGSPSCAELLLEYGAKA 162
++PL A + H A + LL+ G+++NA I + T L AC QG LLL+ A
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278
Query: 163 QLESCLP-SPTHEAASKGHHECLDILISWGIDVD-QEIP-HLGTPLYVACMSQQFHCIWK 219
+ + +P EAAS G+ E +L+ G DV+ +P T L +A +
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338
Query: 220 LLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSM 278
L+ GA + + K +TPL AA ++V LL++ GAD++A + + P+ A
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398
Query: 279 VE--RILLQH---------------EATPSSLYQLCRLCIRSYI 305
V+ R L++ T + + C LC+ S +
Sbjct: 1399 VKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1442
Score = 81.6 bits (200), Expect = 9e-16
Identities = 63/189 (33%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
L EA G + R LL G VN +PL A G HV A L+E GA++ +
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDILISWG 191
+G TPL A +G LLL GA AQ E + A G E D LI G
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVN 250
D++ TPL A + LL AGA+V DT L A + T++ +
Sbjct: 558 ADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
Query: 251 LLLEFGADI 259
+LL+ GAD+
Sbjct: 615 VLLQAGADL 623
Score = 80.9 bits (198), Expect = 1e-15
Identities = 73/225 (32%), Positives = 104/225 (46%), Gaps = 7/225 (3%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPL AA G + L+ +G ++ V + TPL EA H LL GAN+NA
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 132 ITID-GVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISW 190
T + T L AC G A+ L++ GA +L C +P EAA +GH E + L++
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIEL-GC-STPLMEAAQEGHLELVKYLLAA 586
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G +V T L AC + LL AGAD++ + + TPL AA+ V
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 250 NLLLEFGADIN---AKNTELLRPIDVATSSSMVERILLQHEATPS 291
L+ GA++N A N + + A V +LL H A P+
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Score = 75.5 bits (184), Expect = 6e-14
Identities = 74/268 (27%), Positives = 104/268 (38%), Gaps = 37/268 (13%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD------- 102
EAA + +D L EA S+G + A+R LL +G +VN T +
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 103 ---------------------------HVTPLHEACLGDHVACARTLLEAGANVNAITID 135
+TPL A G HV + LL A+VNA +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 136 GVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISWGIDV 194
G T L AC+ G ++LLE GA + +P EA S GH E +L+ G +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 195 DQEIPHL-GTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLL 252
+ + L +AC + LL AGAD + K T L A E+ LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 253 LEFGADINAKNTELLRPIDVATSSSMVE 280
L+ GA +N P+ +A VE
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVE 481
Score = 70.9 bits (172), Expect = 2e-12
Identities = 71/222 (31%), Positives = 105/222 (47%), Gaps = 12/222 (5%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA---IT 133
A + G ++TLL +G ++ TPL A HV LL+ GA++ A T
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
D TPL ACS G ELLL GA + + +P AAS G+ + IL++ G
Sbjct: 1150 KD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1207
Query: 193 DVDQEI-PHLG-TPLYVACMSQQFHCIWKLLYAGADV--QKGKYWDTPLHAAAQQSSTEI 248
+++ LG +PL +A M+ + LL G+D+ Q +T L A Q TE+
Sbjct: 1208 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1267
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
V+LLL+ A++ + L P+ A S E R+LL A
Sbjct: 1268 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/139 (31%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PL EAA +G L ++ LL+ G NV+A T T L AC H A LL+AGA++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPT--HEAASKGHHECLDILIS 189
+ G TPL A G + L+ GA + T A + GH +++L++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 190 WGIDVDQEIPHLGTPLYVA 208
G D + T L A
Sbjct: 686 HGADPTHRLKDGSTMLIEA 704
Score = 52.8 bits (125), Expect = 4e-07
Identities = 36/90 (40%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTL--DHVTPLHEACLGDHVACARTLLEAGAN 128
R+PL +AA G + ++ L+S+G NVN T DH T L AC G H+A LL GA+
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLAVVELLLAHGAD 689
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEY 158
DG T L A G S LL+Y
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 49.7 bits (117), Expect = 4e-06
Identities = 42/135 (31%), Positives = 60/135 (44%), Gaps = 4/135 (2%)
Query: 162 AQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
AQ ES + A + GH E + L+ G ++ TPL +A + + LL
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 222 YAGADV--QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMV 279
GAD+ Q + DTPL A E+V LLL GA+ +N P+ +A S V
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
Query: 280 E--RILLQHEATPSS 292
+ILL A +S
Sbjct: 1197 NIIKILLNAGAEINS 1211
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 95.1 bits (235), Expect = 7e-20
Identities = 75/238 (31%), Positives = 108/238 (45%), Gaps = 3/238 (1%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A++ + + +G D +PL AA+ G + ++ LL+ +VNA + T L
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 110 ACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--C 167
AC G +V + LLE+GA++ +G TPL A S G A LLLE GA S
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 168 LPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
S A KGH E + L+ G D + + + T L ACM LL +GA V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 228 -QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
+++PL AA E+ LL+E GA + N E P+ A E + L
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/166 (35%), Positives = 83/166 (50%), Gaps = 5/166 (3%)
Query: 102 DHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA- 160
+H T L AC G H +TLLE GA++ G TPL A + G E+LL+ GA
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
Query: 161 -KAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWK 219
+AQ E +P A S G E +++L++ G + + TPL +A + I
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 220 LLYAGADVQK---GKYWDTPLHAAAQQSSTEIVNLLLEFGADINAK 262
LL AGA++ K +PL AA T V LLL+ G+DINA+
Sbjct: 951 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996
Score = 82.4 bits (202), Expect = 5e-16
Identities = 78/284 (27%), Positives = 130/284 (45%), Gaps = 25/284 (8%)
Query: 46 GNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDH-- 103
G R+E + G + + +D +PL AAS G + ++ LL+ G +N+ T
Sbjct: 909 GGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967
Query: 104 VTPLHEACLGDHVACARTLLEAGANVNA-ITIDGVTPLFNACSQGSPSCAELLLEYGAKA 162
++PL A + H A + LL+ G+++NA I + T L AC QG LLL+ A
Sbjct: 968 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1027
Query: 163 QLESCLP-SPTHEAASKGHHECLDILISWGIDVD-QEIP-HLGTPLYVACMSQQFHCIWK 219
+ + +P EAAS G+ E +L+ G DV+ +P T L +A +
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087
Query: 220 LLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSM 278
L+ GA + + K +TPL AA ++V LL++ GAD++A + + P+ A
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147
Query: 279 VE--RILLQH---------------EATPSSLYQLCRLCIRSYI 305
V+ R L++ T + + C LC+ S +
Sbjct: 1148 VKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1191
Score = 81.6 bits (200), Expect = 9e-16
Identities = 63/189 (33%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
L EA G + R LL G VN +PL A G HV A L+E GA++ +
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDILISWG 191
+G TPL A +G LLL GA AQ E + A G E D LI G
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVN 250
D++ TPL A + LL AGA+V DT L A + T++ +
Sbjct: 558 ADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
Query: 251 LLLEFGADI 259
+LL+ GAD+
Sbjct: 615 VLLQAGADL 623
Score = 80.9 bits (198), Expect = 1e-15
Identities = 73/225 (32%), Positives = 104/225 (46%), Gaps = 7/225 (3%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPL AA G + L+ +G ++ V + TPL EA H LL GAN+NA
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 132 ITID-GVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISW 190
T + T L AC G A+ L++ GA +L C +P EAA +GH E + L++
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIEL-GC-STPLMEAAQEGHLELVKYLLAA 586
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G +V T L AC + LL AGAD++ + + TPL AA+ V
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 250 NLLLEFGADIN---AKNTELLRPIDVATSSSMVERILLQHEATPS 291
L+ GA++N A N + + A V +LL H A P+
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Score = 75.5 bits (184), Expect = 6e-14
Identities = 74/268 (27%), Positives = 104/268 (38%), Gaps = 37/268 (13%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD------- 102
EAA + +D L EA S+G + A+R LL +G +VN T +
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 103 ---------------------------HVTPLHEACLGDHVACARTLLEAGANVNAITID 135
+TPL A G HV + LL A+VNA +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 136 GVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISWGIDV 194
G T L AC+ G ++LLE GA + +P EA S GH E +L+ G +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 195 DQEIPHL-GTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLL 252
+ + L +AC + LL AGAD + K T L A E+ LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 253 LEFGADINAKNTELLRPIDVATSSSMVE 280
L+ GA +N P+ +A VE
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVE 481
Score = 70.9 bits (172), Expect = 2e-12
Identities = 71/222 (31%), Positives = 105/222 (47%), Gaps = 12/222 (5%)
Query: 77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA---IT 133
A + G ++TLL +G ++ TPL A HV LL+ GA++ A T
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGI 192
D TPL ACS G ELLL GA + + +P AAS G+ + IL++ G
Sbjct: 899 KD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 956
Query: 193 DVDQEI-PHLG-TPLYVACMSQQFHCIWKLLYAGADV--QKGKYWDTPLHAAAQQSSTEI 248
+++ LG +PL +A M+ + LL G+D+ Q +T L A Q TE+
Sbjct: 957 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1016
Query: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVE--RILLQHEA 288
V+LLL+ A++ + L P+ A S E R+LL A
Sbjct: 1017 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1058
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/139 (31%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PL EAA +G L ++ LL+ G NV+A T T L AC H A LL+AGA++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPT--HEAASKGHHECLDILIS 189
+ G TPL A G + L+ GA + T A + GH +++L++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 190 WGIDVDQEIPHLGTPLYVA 208
G D + T L A
Sbjct: 686 HGADPTHRLKDGSTMLIEA 704
Score = 52.8 bits (125), Expect = 4e-07
Identities = 36/90 (40%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTL--DHVTPLHEACLGDHVACARTLLEAGAN 128
R+PL +AA G + ++ L+S+G NVN T DH T L AC G H+A LL GA+
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLAVVELLLAHGAD 689
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEY 158
DG T L A G S LL+Y
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 49.7 bits (117), Expect = 4e-06
Identities = 42/135 (31%), Positives = 60/135 (44%), Gaps = 4/135 (2%)
Query: 162 AQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
AQ ES + A + GH E + L+ G ++ TPL +A + + LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 222 YAGADV--QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMV 279
GAD+ Q + DTPL A E+V LLL GA+ +N P+ +A S V
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 945
Query: 280 E--RILLQHEATPSS 292
+ILL A +S
Sbjct: 946 NIIKILLNAGAEINS 960
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 94.7 bits (234), Expect = 1e-19
Identities = 82/267 (30%), Positives = 123/267 (46%), Gaps = 14/267 (5%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTL-DHVTPLHEACLGDHVACARTLLEAGAN---V 129
LH +A++G+ +R L G + L T LH A + AR +LE+ +
Sbjct: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
Query: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILI 188
NA + DG TPL A G S LLLE+ A+ L +P A + C+ IL+
Sbjct: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
Query: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWD--TPLHAAAQQSST 246
++D + L Y S +C L GAD G+ D TPLH +A +
Sbjct: 171 DHNANIDIQNGFLLR--YAVIKSNHSYCRM-FLQRGADTNLGRLEDGQTPLHLSALRDDV 227
Query: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQ--HEAT--PSSLYQLCRLCIR 302
+L +GAD N +N E P+ V+ S S R L E T P +L LCR+ IR
Sbjct: 228 LCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIR 287
Query: 303 SYIGKPRLHLIPQLQLPTLLKNFLQYR 329
IG L L+ +L + ++K++L+++
Sbjct: 288 QCIGLQNLKLLDELPIAKVMKDYLKHK 314
>gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [Homo
sapiens]
Length = 309
Score = 94.4 bits (233), Expect = 1e-19
Identities = 78/271 (28%), Positives = 128/271 (47%), Gaps = 41/271 (15%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PL AAS G L L+ LL+ G +V+++ + TPL A H+ C R LLEAGA+
Sbjct: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP----------SPTHEAASKGHH 181
+ +P+ A G+ + + LL++GA+A +++ LP P + AA GH
Sbjct: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
Query: 182 ECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAA 241
+C +L+ G D D ++C + L A + + LH
Sbjct: 186 DCFRLLLLHGADPD------------------YNCTDQGLLARVPRPR-TLLEICLH--- 223
Query: 242 QQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCI 301
E + LL++FGA+I + L D+ + +LLQ ATP SL RL +
Sbjct: 224 HNCEPEYIQLLIDFGANIYLPSLSL----DLTSQDDKGIALLLQARATPRSLLSQVRLVV 279
Query: 302 RSYI---GKPRLHLIPQLQLPTLLKNFLQYR 329
R + G+P+ I QL +P +L ++L+++
Sbjct: 280 RRALCQAGQPQ--AINQLDIPPMLISYLKHQ 308
Score = 33.9 bits (76), Expect = 0.20
Identities = 29/90 (32%), Positives = 35/90 (38%), Gaps = 3/90 (3%)
Query: 202 GTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIVNLLLEFGADIN 260
GTPL +A C+ LL GADV TPL A + V +LLE GA
Sbjct: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
Query: 261 AKNTELLRPIDVATSSSMVERI--LLQHEA 288
P+ A V + LL H A
Sbjct: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGA 154
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 93.2 bits (230), Expect = 3e-19
Identities = 79/274 (28%), Positives = 119/274 (43%), Gaps = 32/274 (11%)
Query: 68 WADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGA 127
W +PL AA+ G + L+ +G V+ V + T L+ A + H+ + LLEAGA
Sbjct: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
Query: 128 NVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDIL 187
+ N TP+++A G + L+ YGA + HH D+
Sbjct: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV--------------NHHLTPDVQ 181
Query: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ---------KGKYWDTP-- 236
+ + + PLY++ C LL AGA+ +G Y +P
Sbjct: 182 PRFSRRLTSLVV---CPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
Query: 237 -LHAAAQQS-STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEA--TPSS 292
+ A + V+LL+EFGA++N E L P E + + EA P +
Sbjct: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
Query: 293 LYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFL 326
L LCR+ +R +GK RLHLIP L LP +K FL
Sbjct: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFL 332
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 92.0 bits (227), Expect = 6e-19
Identities = 72/238 (30%), Positives = 107/238 (44%), Gaps = 3/238 (1%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A++ + + +G+ D +PL A+S G L ++ LL +VN+ + T L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 110 ACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--C 167
AC G V + LL GAN+ +G TPL A S G A +LL++GA S
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 168 LPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
S A KGH + + L+ G D + + + T L ACM LL +GA V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 228 -QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
+++PL AA E+ LL+E GA++ N E P+ A E + L
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVAL 489
Score = 84.0 bits (206), Expect = 2e-16
Identities = 67/205 (32%), Positives = 90/205 (43%), Gaps = 8/205 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
L EA G + R LL G VN +PL A G HV A L+E GAN+ +
Sbjct: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDILISWG 191
+G TPL A +G LLL GA AQ E + A G E D LI G
Sbjct: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVN 250
D++ TPL A + LL +GA+V DT L A + T++ +
Sbjct: 529 ADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
Query: 251 LLLEFGADINAKN--TELLRPIDVA 273
+LL+ GAD++ + +L ID A
Sbjct: 586 VLLQAGADLDKQEDMKTILEGIDPA 610
Score = 69.3 bits (168), Expect = 4e-12
Identities = 71/268 (26%), Positives = 101/268 (37%), Gaps = 37/268 (13%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD------- 102
EAA D L EA S G + A+R LL +G +VN T +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 103 ---------------------------HVTPLHEACLGDHVACARTLLEAGANVNAITID 135
+TPL A G ++ + LL A+VN+ +
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 136 GVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISWGIDV 194
G T L AC+ G ++LL GA + +P EAAS GH E +L+ G +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 195 DQEIPHL-GTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLL 252
+ + L +AC + LL AGAD + K T L A E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 253 LEFGADINAKNTELLRPIDVATSSSMVE 280
L+ GA +N P+ +A VE
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVE 452
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/159 (34%), Positives = 75/159 (47%), Gaps = 3/159 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPL AA G + L+ +G N+ V + TPL EA H LL GAN+NA
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 132 ITID-GVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISW 190
T + T L AC G A+ L++ GA +L C +P EA+ +GH E + L++
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIEL-GC-STPLMEASQEGHLELVKYLLAS 557
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK 229
G +V T L AC + LL AGAD+ K
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 12/85 (14%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN- 130
+PL EA+ +G L ++ LL+ G NV+A T T L AC H A LL+AGA+++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
Query: 131 ----AITIDGVTP-------LFNAC 144
++G+ P F+AC
Sbjct: 597 QEDMKTILEGIDPAKHQVRVAFDAC 621
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 92.0 bits (227), Expect = 6e-19
Identities = 72/238 (30%), Positives = 107/238 (44%), Gaps = 3/238 (1%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A++ + + +G+ D +PL A+S G L ++ LL +VN+ + T L
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
Query: 110 ACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--C 167
AC G V + LL GAN+ +G TPL A S G A +LL++GA S
Sbjct: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360
Query: 168 LPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
S A KGH + + L+ G D + + + T L ACM LL +GA V
Sbjct: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
Query: 228 -QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
+++PL AA E+ LL+E GA++ N E P+ A E + L
Sbjct: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVAL 478
Score = 84.0 bits (206), Expect = 2e-16
Identities = 67/205 (32%), Positives = 90/205 (43%), Gaps = 8/205 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
L EA G + R LL G VN +PL A G HV A L+E GAN+ +
Sbjct: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDILISWG 191
+G TPL A +G LLL GA AQ E + A G E D LI G
Sbjct: 458 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 517
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVN 250
D++ TPL A + LL +GA+V DT L A + T++ +
Sbjct: 518 ADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
Query: 251 LLLEFGADINAKN--TELLRPIDVA 273
+LL+ GAD++ + +L ID A
Sbjct: 575 VLLQAGADLDKQEDMKTILEGIDPA 599
Score = 69.3 bits (168), Expect = 4e-12
Identities = 71/268 (26%), Positives = 101/268 (37%), Gaps = 37/268 (13%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD------- 102
EAA D L EA S G + A+R LL +G +VN T +
Sbjct: 174 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 233
Query: 103 ---------------------------HVTPLHEACLGDHVACARTLLEAGANVNAITID 135
+TPL A G ++ + LL A+VN+ +
Sbjct: 234 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 293
Query: 136 GVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISWGIDV 194
G T L AC+ G ++LL GA + +P EAAS GH E +L+ G +
Sbjct: 294 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 353
Query: 195 DQEIPHL-GTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLL 252
+ + L +AC + LL AGAD + K T L A E+ LL
Sbjct: 354 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 413
Query: 253 LEFGADINAKNTELLRPIDVATSSSMVE 280
L+ GA +N P+ +A VE
Sbjct: 414 LDSGAQVNMPADSFESPLTLAACGGHVE 441
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/159 (34%), Positives = 75/159 (47%), Gaps = 3/159 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPL AA G + L+ +G N+ V + TPL EA H LL GAN+NA
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
Query: 132 ITID-GVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISW 190
T + T L AC G A+ L++ GA +L C +P EA+ +GH E + L++
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIEL-GC-STPLMEASQEGHLELVKYLLAS 546
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK 229
G +V T L AC + LL AGAD+ K
Sbjct: 547 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 12/85 (14%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVN- 130
+PL EA+ +G L ++ LL+ G NV+A T T L AC H A LL+AGA+++
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
Query: 131 ----AITIDGVTP-------LFNAC 144
++G+ P F+AC
Sbjct: 586 QEDMKTILEGIDPAKHQVRVAFDAC 610
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 92.0 bits (227), Expect = 6e-19
Identities = 72/238 (30%), Positives = 107/238 (44%), Gaps = 3/238 (1%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHE 109
E A++ + + +G+ D +PL A+S G L ++ LL +VN+ + T L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 110 ACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLES--C 167
AC G V + LL GAN+ +G TPL A S G A +LL++GA S
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 168 LPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADV 227
S A KGH + + L+ G D + + + T L ACM LL +GA V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 228 -QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILL 284
+++PL AA E+ LL+E GA++ N E P+ A E + L
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVAL 489
Score = 83.2 bits (204), Expect = 3e-16
Identities = 63/189 (33%), Positives = 83/189 (43%), Gaps = 6/189 (3%)
Query: 74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAIT 133
L EA G + R LL G VN +PL A G HV A L+E GAN+ +
Sbjct: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
Query: 134 IDGVTPLFNACSQGSPSCAELLLEYGA--KAQLESCLPSPTHEAASKGHHECLDILISWG 191
+G TPL A +G LLL GA AQ E + A G E D LI G
Sbjct: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
Query: 192 IDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVN 250
D++ TPL A + LL +GA+V DT L A + T++ +
Sbjct: 529 ADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
Query: 251 LLLEFGADI 259
+LL+ GAD+
Sbjct: 586 VLLQAGADL 594
Score = 82.0 bits (201), Expect = 7e-16
Identities = 73/225 (32%), Positives = 104/225 (46%), Gaps = 7/225 (3%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
SPL AA G + L+ +G N+ V + TPL EA H LL GAN+NA
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 132 ITID-GVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISW 190
T + T L AC G A+ L++ GA +L C +P EA+ +GH E + L++
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIEL-GC-STPLMEASQEGHLELVKYLLAS 557
Query: 191 GIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIV 249
G +V T L AC + LL AGAD++ + + TPL AA+ V
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 250 NLLLEFGADIN---AKNTELLRPIDVATSSSMVERILLQHEATPS 291
L+ GA++N A N + + A V +LL H A P+
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Score = 79.3 bits (194), Expect = 4e-15
Identities = 68/225 (30%), Positives = 103/225 (45%), Gaps = 14/225 (6%)
Query: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNA-VTLDHVTPLHEACLGDHVACARTLLE 124
GS SPL AA G + A++ LL G ++NA + + T L AC LL+
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
Query: 125 AGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ---LESCLPSPTHEAASKGHH 181
ANV G+TPL A S G +LL+ GA + S + AA KGH+
Sbjct: 1246 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305
Query: 182 ECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWD-TPLHAA 240
+ ++LI G +D TPL++A F + L+ AGADV TPL +A
Sbjct: 1306 KFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSA 1365
Query: 241 AQQSSTEIVNLLL----EFGADINAKNTELLRPIDVATSSSMVER 281
++ ++V L+ +F +DI E +R I T ++++
Sbjct: 1366 FRKGHVKVVQYLVKEVNQFPSDI-----ECMRYIATITDKELLKK 1405
Score = 72.4 bits (176), Expect = 5e-13
Identities = 54/166 (32%), Positives = 76/166 (45%), Gaps = 5/166 (3%)
Query: 102 DHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA- 160
+H T L AC G H L+ A + G TPL A + G E+LL+ G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 161 -KAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWK 219
+AQ E +P A S G E +D+L++ G + + TPL +A + I
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 220 LLYAGADVQK---GKYWDTPLHAAAQQSSTEIVNLLLEFGADINAK 262
LL AGA++ K +PL AA V LLL+ G+DINA+
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
Score = 72.0 bits (175), Expect = 7e-13
Identities = 69/251 (27%), Positives = 109/251 (43%), Gaps = 40/251 (15%)
Query: 60 GVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA 119
G + Q +PL A S GR + LL++G N + TPL A G +V
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 120 RTLLEAGANVNAITID--GVTPLFNACSQGSPSCAELLLEYGA--KAQLE---------S 166
+ LL AGA +N+ T G++PL A G +LLL+ G+ AQ+E +
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 167 CLP------------------------SPTHEAASKGHHECLDILISWGIDVD-QEIP-H 200
C +P EAAS G+ E +L+ G DV+ +P
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 201 LGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADI 259
T L +A + L++ GA + + K +TPL A+ ++V LL++ GAD+
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Query: 260 NAKNTELLRPI 270
+A + + P+
Sbjct: 1352 DAADNRKITPL 1362
Score = 69.3 bits (168), Expect = 4e-12
Identities = 71/268 (26%), Positives = 101/268 (37%), Gaps = 37/268 (13%)
Query: 50 EAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD------- 102
EAA D L EA S G + A+R LL +G +VN T +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 103 ---------------------------HVTPLHEACLGDHVACARTLLEAGANVNAITID 135
+TPL A G ++ + LL A+VN+ +
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 136 GVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILISWGIDV 194
G T L AC+ G ++LL GA + +P EAAS GH E +L+ G +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 195 DQEIPHL-GTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLL 252
+ + L +AC + LL AGAD + K T L A E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 253 LEFGADINAKNTELLRPIDVATSSSMVE 280
L+ GA +N P+ +A VE
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVE 452
Score = 60.1 bits (144), Expect = 3e-09
Identities = 45/152 (29%), Positives = 68/152 (44%), Gaps = 2/152 (1%)
Query: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
+PL EA+ +G L ++ LL+ G NV+A T T L AC H A LL+AGA++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPT--HEAASKGHHECLDILIS 189
+ G TPL A G + L+ GA + T A + GH +++L++
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 190 WGIDVDQEIPHLGTPLYVACMSQQFHCIWKLL 221
G D + T L A + + LL
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTL--DHVTPLHEACLGDHVACARTLLEAGAN 128
R+PL +AA G L ++ L+S+G NVN T DH T + AC G H+A LL GA+
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGAD 660
Query: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEY 158
DG T L A G + LL+Y
Sbjct: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 35.8 bits (81), Expect = 0.054
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 32/171 (18%)
Query: 112 LGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSP 171
L D +A T + G+N ++ T + +TP +CSQ + + A + PS
Sbjct: 996 LDDLIAAVSTRVPTGSNSSSQTTECLTP--ESCSQTTSNVAS--------QSMPPVYPSV 1045
Query: 172 THEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KG 230
+A ++ +H+ T L +AC + L+ A ++ +
Sbjct: 1046 DIDAHTESNHD--------------------TALTLACAGGHEELVSVLIARDAKIEHRD 1085
Query: 231 KYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELL-RPIDVATSSSMVE 280
K TPL AA +V +LL+ G DI A++ P+ +A S E
Sbjct: 1086 KKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,256,454
Number of Sequences: 37866
Number of extensions: 544035
Number of successful extensions: 5007
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 1078
Number of HSP's gapped (non-prelim): 1774
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.