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Search of human proteins with 18087841
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18087841 WD repeat domain 89 [Homo sapiens]
(387 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57165359 WD repeat domain 89 [Homo sapiens] 798 0.0
gi|18087841 WD repeat domain 89 [Homo sapiens] 798 0.0
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 52 1e-06
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 52 1e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 47 3e-05
gi|38605733 nucleoporin 43kDa [Homo sapiens] 47 4e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 47 4e-05
gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens] 46 5e-05
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 46 5e-05
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 46 5e-05
gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens] 46 6e-05
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 46 6e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 45 8e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 45 8e-05
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 45 8e-05
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 45 8e-05
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 45 8e-05
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 45 1e-04
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 45 1e-04
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 44 2e-04
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 44 2e-04
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 44 3e-04
gi|26665869 WD repeat domain 51B [Homo sapiens] 44 3e-04
gi|14149987 WD repeat domain 24 [Homo sapiens] 43 4e-04
gi|32189425 WD repeat domain 69 [Homo sapiens] 43 6e-04
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s... 43 6e-04
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo... 43 6e-04
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 41 0.002
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 41 0.002
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 41 0.002
>gi|57165359 WD repeat domain 89 [Homo sapiens]
Length = 387
Score = 798 bits (2062), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL 60
MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL
Sbjct: 1 MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL 60
Query: 61 NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS 120
NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS
Sbjct: 61 NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS 120
Query: 121 FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP 180
FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP
Sbjct: 121 FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP 180
Query: 181 SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG 240
SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG
Sbjct: 181 SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG 240
Query: 241 FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI 300
FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI
Sbjct: 241 FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI 300
Query: 301 HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK 360
HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK
Sbjct: 301 HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK 360
Query: 361 ESMKIASSVHQRVRVHSNDSYKRRKKQ 387
ESMKIASSVHQRVRVHSNDSYKRRKKQ
Sbjct: 361 ESMKIASSVHQRVRVHSNDSYKRRKKQ 387
>gi|18087841 WD repeat domain 89 [Homo sapiens]
Length = 387
Score = 798 bits (2062), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL 60
MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL
Sbjct: 1 MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERL 60
Query: 61 NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS 120
NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS
Sbjct: 61 NVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFIS 120
Query: 121 FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP 180
FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP
Sbjct: 121 FDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHP 180
Query: 181 SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG 240
SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG
Sbjct: 181 SNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEG 240
Query: 241 FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI 300
FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI
Sbjct: 241 FYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRI 300
Query: 301 HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK 360
HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK
Sbjct: 301 HLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKK 360
Query: 361 ESMKIASSVHQRVRVHSNDSYKRRKKQ 387
ESMKIASSVHQRVRVHSNDSYKRRKKQ
Sbjct: 361 ESMKIASSVHQRVRVHSNDSYKRRKKQ 387
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 46 LCSNG---SIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVA 102
LCS G ++ ++D V+R+F G+ G +N V+F + S D +++CWD R
Sbjct: 82 LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSR 141
Query: 103 REKPVQLFKGYPSNIFISFDINCNDHIICAGT 134
R +PVQ + + +DH I AG+
Sbjct: 142 RPEPVQTLDEARDGV---SSVKVSDHEILAGS 170
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 46 LCSNG---SIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVA 102
LCS G ++ ++D V+R+F G+ G +N V+F + S D +++CWD R
Sbjct: 82 LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSR 141
Query: 103 REKPVQLFKGYPSNIFISFDINCNDHIICAGT 134
R +PVQ + + +DH I AG+
Sbjct: 142 RPEPVQTLDEARDGV---SSVKVSDHEILAGS 170
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 47.0 bits (110), Expect = 3e-05
Identities = 41/161 (25%), Positives = 66/161 (40%), Gaps = 17/161 (10%)
Query: 40 ENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDA 99
E L+ +GSIR++D E +LR G+ + + F + V S D +K WD
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
Query: 100 RVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTK 159
R R+ V ++G+ + + A DD + WD T
Sbjct: 135 R--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAA-----DDHTVKLWD---------LTA 178
Query: 160 DSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDI 200
+ + H+ V V FHP N ++ SGSSD + +D+
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHP-NEYLLASGSSDRTIRFWDL 218
Score = 31.2 bits (69), Expect = 1.7
Identities = 18/52 (34%), Positives = 26/52 (50%)
Query: 40 ENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTD 91
E L+A S+ +IR +D E+ V+ G PG + V F +YS C D
Sbjct: 201 EYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
>gi|38605733 nucleoporin 43kDa [Homo sapiens]
Length = 380
Score = 46.6 bits (109), Expect = 4e-05
Identities = 38/171 (22%), Positives = 71/171 (41%), Gaps = 24/171 (14%)
Query: 43 VAVLCSNGSIRIYDKERLNVLREFSGYPG-LLNGVRFANSCDSVYSACTDGTVKCWDARV 101
+ + +G I ++ + +R L+ V F + + + + + G +K WD R
Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPE-ILTVNSIGQLKIWDFRQ 202
Query: 102 AREKPVQLFKGYPSNIFISFDINCND------HIICAGTEKVDDDALLVFWDARMNSQNL 155
+P Q+ + ++C D H++ G + D +L WD R + +
Sbjct: 203 QGNEPSQILSLTGDRV----PLHCVDRHPNQQHVVATGGQ----DGMLSIWDVRQGTMPV 254
Query: 156 STTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEE 206
S K H ++ +V FHPSNP + + S DG + +D + D E
Sbjct: 255 SLLK--------AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPE 297
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 46.6 bits (109), Expect = 4e-05
Identities = 49/173 (28%), Positives = 77/173 (44%), Gaps = 20/173 (11%)
Query: 73 LNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIICA 132
++ V +++ + SA D T+K WD R K ++ KG+ SN + N ++I +
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSG--KCLKTLKGH-SNYVFCCNFNPPSNLIIS 142
Query: 133 GTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSD 192
G+ D + W+ + + L T HSD V+ V F+ S +++VSGS D
Sbjct: 143 GS----FDETVKIWEVK-TGKCLKTL--------SAHSDPVSAVHFNCSG-SLIVSGSYD 188
Query: 193 GLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWD 245
GL ++D LV N VS + +S G K I T D WD
Sbjct: 189 GLCRIWDAASGQCLKTLVDDDN--PPVSFVKFSPNG-KYILTATLDNTLKLWD 238
Score = 35.8 bits (81), Expect = 0.067
Identities = 52/231 (22%), Positives = 93/231 (40%), Gaps = 33/231 (14%)
Query: 30 DTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSAC 89
D+S+ V A + +++++D L+ G+ + F + + S
Sbjct: 94 DSSRLVSASDDK---------TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 90 TDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDAR 149
D TVK W+ + K ++ + S+ + NC+ +I +G+ D L WDA
Sbjct: 145 FDETVKIWEVKTG--KCLKTLSAH-SDPVSAVHFNCSGSLIVSGSY----DGLCRIWDA- 196
Query: 150 MNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDAL 209
+ Q L T D + V+ V+F P N +++ + D + ++D + L
Sbjct: 197 ASGQCLKTLVDD-------DNPPVSFVKFSP-NGKYILTATLDNTLKLWDY---SRGRCL 245
Query: 210 VTTCNSISSVSCI--GWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRL 258
T + CI +S G K I + D Y W +L T E V +L
Sbjct: 246 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW---NLQTKEIVQKL 293
Score = 32.3 bits (72), Expect = 0.74
Identities = 38/181 (20%), Positives = 68/181 (37%), Gaps = 13/181 (7%)
Query: 41 NLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDAR 100
NL+ + +++I++ + L+ S + ++ V F S + S DG + WDA
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 101 VAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKD 160
+ + P F+ F N +I+ A D L WD K
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPN-GKYILTATL-----DNTLKLWDYSRG----RCLKT 247
Query: 161 SLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVS 220
G +E + F + +VSGS D LV ++++ L + + S +
Sbjct: 248 YTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAA 304
Query: 221 C 221
C
Sbjct: 305 C 305
>gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]
Length = 676
Score = 46.2 bits (108), Expect = 5e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 19/169 (11%)
Query: 59 RLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIF 118
RL + E G+ G +N + + D + S D WD + +K + + G+ +NIF
Sbjct: 36 RLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTIVWDP-LHHKKLLSMHTGHTANIF 94
Query: 119 -ISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVR 177
+ F + D I+ G D++++ +L T K+++ + + H++ V ++
Sbjct: 95 SVKFLPHAGDRILITGAA-----------DSKVHVHDL-TVKETIHMFGD-HTNRVKRIA 141
Query: 178 FHPSNPNMVVSGSSDGLVNVFDINIDNEEDA----LVTTCNSISSVSCI 222
P PN S + DGL+ +D+ +++ L C + C+
Sbjct: 142 TAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCL 190
Score = 30.8 bits (68), Expect = 2.2
Identities = 11/32 (34%), Positives = 17/32 (53%)
Query: 319 GHAATVRSFCWNVQDDSLLTGGEDAQLLLWKP 350
GH+ V WN + D L +G +D ++W P
Sbjct: 45 GHSGCVNCLEWNEKGDLLASGSDDQHTIVWDP 76
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 46.2 bits (108), Expect = 5e-05
Identities = 46/238 (19%), Positives = 99/238 (41%), Gaps = 18/238 (7%)
Query: 39 KENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFA-NSCDSVYSACTDGTVKCW 97
K++ CS+ I VL ++ +P + G ++ N+ D + + C D V+ +
Sbjct: 467 KDSKRIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVY 525
Query: 98 DARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLST 157
+ ++P+++F G+ + +F + I+C+G+ DD + WD
Sbjct: 526 YVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS----DDGTVRIWD---------Y 572
Query: 158 TKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSIS 217
T+D+ H+ V + ++ P +++SGS D + V+D D + +
Sbjct: 573 TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVY 632
Query: 218 SVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALD 275
++C + + C + D W L L T + L + E++ + A++
Sbjct: 633 GLTC--HPSRPFTMASC-SRDSTVRLWSLTALVTPVQINILADRSWEEIIGNTDYAIE 687
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/187 (20%), Positives = 72/187 (38%), Gaps = 36/187 (19%)
Query: 169 HSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKG 228
H + + +F P +PN++ + S DG + V+DI N A+ T+ + + + W+ G
Sbjct: 368 HVETIFDCKFKPDDPNLLATASFDGTIKVWDI---NTLTAVYTSPGNEGVIYSLSWAPGG 424
Query: 229 YKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDT 288
I T G + W N+Q + + E T+
Sbjct: 425 LNCIAGGTSRNGAFIW--------------NVQKGKIIQRFNEHG------------TNG 458
Query: 289 LHVIGGTNKGRIHLMNCSMSGLTHVTSLQG------GHAATVRSFCWNVQD-DSLLTGGE 341
+ I ++K + CS G + ++ G H A V W+ + D + TG E
Sbjct: 459 IFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCE 518
Query: 342 DAQLLLW 348
D + ++
Sbjct: 519 DTNVRVY 525
Score = 35.0 bits (79), Expect = 0.11
Identities = 19/91 (20%), Positives = 42/91 (46%), Gaps = 5/91 (5%)
Query: 162 LGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSV-S 220
L A H +T + + P NP++ SGS+D LV ++++ E ++ +S + +
Sbjct: 51 LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNV----AEQKVIAKLDSTKGIPA 106
Query: 221 CIGWSGKGYKQIYCMTHDEGFYWWDLNHLDT 251
+ W + ++H + W ++ D+
Sbjct: 107 SLSWCWNAEDVVAFVSHRGPLFIWTISGPDS 137
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 46.2 bits (108), Expect = 5e-05
Identities = 46/238 (19%), Positives = 99/238 (41%), Gaps = 18/238 (7%)
Query: 39 KENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFA-NSCDSVYSACTDGTVKCW 97
K++ CS+ I VL ++ +P + G ++ N+ D + + C D V+ +
Sbjct: 491 KDSKRIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVY 549
Query: 98 DARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLST 157
+ ++P+++F G+ + +F + I+C+G+ DD + WD
Sbjct: 550 YVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS----DDGTVRIWD---------Y 596
Query: 158 TKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSIS 217
T+D+ H+ V + ++ P +++SGS D + V+D D + +
Sbjct: 597 TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVY 656
Query: 218 SVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALD 275
++C + + C + D W L L T + L + E++ + A++
Sbjct: 657 GLTC--HPSRPFTMASC-SRDSTVRLWSLTALVTPVQINILADRSWEEIIGNTDYAIE 711
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/187 (20%), Positives = 72/187 (38%), Gaps = 36/187 (19%)
Query: 169 HSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKG 228
H + + +F P +PN++ + S DG + V+DI N A+ T+ + + + W+ G
Sbjct: 392 HVETIFDCKFKPDDPNLLATASFDGTIKVWDI---NTLTAVYTSPGNEGVIYSLSWAPGG 448
Query: 229 YKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDT 288
I T G + W N+Q + + E T+
Sbjct: 449 LNCIAGGTSRNGAFIW--------------NVQKGKIIQRFNEHG------------TNG 482
Query: 289 LHVIGGTNKGRIHLMNCSMSGLTHVTSLQG------GHAATVRSFCWNVQD-DSLLTGGE 341
+ I ++K + CS G + ++ G H A V W+ + D + TG E
Sbjct: 483 IFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCE 542
Query: 342 DAQLLLW 348
D + ++
Sbjct: 543 DTNVRVY 549
Score = 35.0 bits (79), Expect = 0.11
Identities = 19/91 (20%), Positives = 42/91 (46%), Gaps = 5/91 (5%)
Query: 162 LGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSV-S 220
L A H +T + + P NP++ SGS+D LV ++++ E ++ +S + +
Sbjct: 75 LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNV----AEQKVIAKLDSTKGIPA 130
Query: 221 CIGWSGKGYKQIYCMTHDEGFYWWDLNHLDT 251
+ W + ++H + W ++ D+
Sbjct: 131 SLSWCWNAEDVVAFVSHRGPLFIWTISGPDS 161
>gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens]
Length = 597
Score = 45.8 bits (107), Expect = 6e-05
Identities = 70/343 (20%), Positives = 128/343 (37%), Gaps = 49/343 (14%)
Query: 40 ENLVAVLCS--NGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCW 97
E L VL +G +RI++ + N +R + G + G+ S ++ D TVK W
Sbjct: 229 EKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQW 288
Query: 98 DARVA----REKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQ 153
E+P+ G ++ D + + + ++VD WD + +
Sbjct: 289 KMDGPGYGDEEEPLHTILG--KTVYTGIDHHWKEAVFATCGQQVD------IWDEQRTNP 340
Query: 154 NLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTC 213
S T D ++ V+F+P ++ S +SD + ++D+ ++
Sbjct: 341 ICSMTWGF---------DSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDM 391
Query: 214 NSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDA 273
+ + I W+ D Y +D+ LDT V ++ V +V
Sbjct: 392 RT----NTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDV------- 440
Query: 274 LDYLIGGLYHEKTDTLHVIGGTNKG-RIHLMNCSMS-GLTHVTSLQGGHAATVRSFCWNV 331
DY T V +K RI ++ S S + H +Q H V+ W
Sbjct: 441 -DY-------SPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQ--HVICVK---WTS 487
Query: 332 QDDSLLTGGEDAQLLLWKPGAIEKTFTKKESMKIASSVHQRVR 374
++ G ++ + LWK A EK K A +Q+++
Sbjct: 488 DSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLK 530
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 45.8 bits (107), Expect = 6e-05
Identities = 55/222 (24%), Positives = 91/222 (40%), Gaps = 46/222 (20%)
Query: 155 LSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCN 214
L T L A ++ ++ V F P + V GS D LV V+ ++ + + + C+
Sbjct: 445 LDTETHDLVAIHTDGNEQISVVSFSPDGAYLAV-GSHDNLVYVYTVDQGGRKVSRLGKCS 503
Query: 215 SISS-VSCIGWSGKGYKQIYCMTHDEGFY---WWDLNHLDTDEPVTRLNIQDVREVVNMK 270
SS ++ + W+ + C + G Y +WD P T I V NM+
Sbjct: 504 GHSSFITHLDWA----QDSSCFVTNSGDYEILYWD--------PATCKQITSADAVRNME 551
Query: 271 EDALDYLIG----GLYHEKTDTLHV------------IGGTNKGRIHLMN---CSMSGLT 311
++G G++ E D + + G++HL + C L+
Sbjct: 552 WATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALS 611
Query: 312 HVTSLQGGHAATVR--SFCWNVQDDS--LLTGGEDAQLLLWK 349
H GGH++ V +F W DDS L TGG+D +L W+
Sbjct: 612 HK---YGGHSSHVTNVAFLW---DDSMALTTGGKDTSVLQWR 647
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.4 bits (106), Expect = 8e-05
Identities = 49/182 (26%), Positives = 82/182 (45%), Gaps = 20/182 (10%)
Query: 64 REFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDI 123
+ SG+ ++ V +++ + + SA D T+K WD V+ K ++ KG+ SN +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD--VSSGKCLKTLKGH-SNYVFCCNF 137
Query: 124 NCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNP 183
N ++I +G+ D + WD + + L T HSD V+ V F+ +
Sbjct: 138 NPQSNLIVSGS----FDESVRIWDVK-TGKCLKTL--------PAHSDPVSAVHFN-RDG 183
Query: 184 NMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYW 243
+++VS S DGL ++D L+ N VS + +S G K I T D
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVKFSPNG-KYILAATLDNTLKL 240
Query: 244 WD 245
WD
Sbjct: 241 WD 242
Score = 38.1 bits (87), Expect = 0.014
Identities = 39/154 (25%), Positives = 67/154 (43%), Gaps = 19/154 (12%)
Query: 67 SGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAR-EKPVQLFKGYPSNIFISFDINC 125
+G+ ++ V+F+ + + + S+ D +K W A + EK + K S++ S D N
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 126 NDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNM 185
DD L WD + + L T K HS+ V F+P + N+
Sbjct: 102 --------LVSASDDKTLKIWDV-SSGKCLKTLKG--------HSNYVFCCNFNPQS-NL 143
Query: 186 VVSGSSDGLVNVFDINIDNEEDALVTTCNSISSV 219
+VSGS D V ++D+ L + +S+V
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Score = 34.7 bits (78), Expect = 0.15
Identities = 38/183 (20%), Positives = 67/183 (36%), Gaps = 13/183 (7%)
Query: 39 KENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWD 98
+ NL+ + S+RI+D + L+ + ++ V F + S+ DG + WD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 99 ARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTT 158
+ + P F+ F N +I+ A D L WD
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPN-GKYILAATL-----DNTLKLWDYSKG----KCL 249
Query: 159 KDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISS 218
K G +E + F + +VSGS D LV ++++ L + + S
Sbjct: 250 KTYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306
Query: 219 VSC 221
+C
Sbjct: 307 TAC 309
Score = 30.8 bits (68), Expect = 2.2
Identities = 52/236 (22%), Positives = 92/236 (38%), Gaps = 30/236 (12%)
Query: 27 LGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVY 86
LGI S + NL+ + +++I+D L+ G+ + F + +
Sbjct: 88 LGI--SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 87 SACTDGTVKCWDARVAREKPVQLFKGYP--SNIFISFDINCNDHIICAGTEKVDDDALLV 144
S D +V+ WD + + K P S+ + N + +I + + D L
Sbjct: 146 SGSFDESVRIWDVKTGK-----CLKTLPAHSDPVSAVHFNRDGSLIVSSSY----DGLCR 196
Query: 145 FWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDN 204
WD + Q L T D + V+ V+F P N +++ + D + ++D +
Sbjct: 197 IWDT-ASGQCLKTLIDD-------DNPPVSFVKFSP-NGKYILAATLDNTLKLWDY---S 244
Query: 205 EEDALVTTCNSISSVSCI--GWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRL 258
+ L T + CI +S G K I + D Y W +L T E V +L
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW---NLQTKEIVQKL 297
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.4 bits (106), Expect = 8e-05
Identities = 49/182 (26%), Positives = 82/182 (45%), Gaps = 20/182 (10%)
Query: 64 REFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDI 123
+ SG+ ++ V +++ + + SA D T+K WD V+ K ++ KG+ SN +
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD--VSSGKCLKTLKGH-SNYVFCCNF 137
Query: 124 NCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNP 183
N ++I +G+ D + WD + + L T HSD V+ V F+ +
Sbjct: 138 NPQSNLIVSGS----FDESVRIWDVK-TGKCLKTL--------PAHSDPVSAVHFN-RDG 183
Query: 184 NMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYW 243
+++VS S DGL ++D L+ N VS + +S G K I T D
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVKFSPNG-KYILAATLDNTLKL 240
Query: 244 WD 245
WD
Sbjct: 241 WD 242
Score = 38.1 bits (87), Expect = 0.014
Identities = 39/154 (25%), Positives = 67/154 (43%), Gaps = 19/154 (12%)
Query: 67 SGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAR-EKPVQLFKGYPSNIFISFDINC 125
+G+ ++ V+F+ + + + S+ D +K W A + EK + K S++ S D N
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 126 NDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNM 185
DD L WD + + L T K HS+ V F+P + N+
Sbjct: 102 --------LVSASDDKTLKIWDV-SSGKCLKTLKG--------HSNYVFCCNFNPQS-NL 143
Query: 186 VVSGSSDGLVNVFDINIDNEEDALVTTCNSISSV 219
+VSGS D V ++D+ L + +S+V
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Score = 34.7 bits (78), Expect = 0.15
Identities = 38/183 (20%), Positives = 67/183 (36%), Gaps = 13/183 (7%)
Query: 39 KENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWD 98
+ NL+ + S+RI+D + L+ + ++ V F + S+ DG + WD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 99 ARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTT 158
+ + P F+ F N +I+ A D L WD
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPN-GKYILAATL-----DNTLKLWDYSKG----KCL 249
Query: 159 KDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISS 218
K G +E + F + +VSGS D LV ++++ L + + S
Sbjct: 250 KTYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306
Query: 219 VSC 221
+C
Sbjct: 307 TAC 309
Score = 30.8 bits (68), Expect = 2.2
Identities = 52/236 (22%), Positives = 92/236 (38%), Gaps = 30/236 (12%)
Query: 27 LGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVY 86
LGI S + NL+ + +++I+D L+ G+ + F + +
Sbjct: 88 LGI--SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 87 SACTDGTVKCWDARVAREKPVQLFKGYP--SNIFISFDINCNDHIICAGTEKVDDDALLV 144
S D +V+ WD + + K P S+ + N + +I + + D L
Sbjct: 146 SGSFDESVRIWDVKTGK-----CLKTLPAHSDPVSAVHFNRDGSLIVSSSY----DGLCR 196
Query: 145 FWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDN 204
WD + Q L T D + V+ V+F P N +++ + D + ++D +
Sbjct: 197 IWDT-ASGQCLKTLIDD-------DNPPVSFVKFSP-NGKYILAATLDNTLKLWDY---S 244
Query: 205 EEDALVTTCNSISSVSCI--GWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRL 258
+ L T + CI +S G K I + D Y W +L T E V +L
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW---NLQTKEIVQKL 297
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 45.4 bits (106), Expect = 8e-05
Identities = 44/177 (24%), Positives = 78/177 (44%), Gaps = 23/177 (12%)
Query: 73 LNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDI---NCNDHI 129
L+ F NS + +A DGT WD V + +Q F G+ +++ + D+ +
Sbjct: 156 LSACSFTNSDMQILTASGDGTCALWD--VESGQLLQSFHGHGADV-LCLDLAPSETGNTF 212
Query: 130 ICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSG 189
+ G +K + WD R + A+ ETH D+ VR++PS + SG
Sbjct: 213 VSGGCDKK-----AMVWDMRSGQ--------CVQAF-ETHESDINSVRYYPSG-DAFASG 257
Query: 190 SSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDL 246
S D ++D+ D E A+ + + I S + +S G + ++ +D WD+
Sbjct: 258 SDDATCRLYDLRADREV-AIYSKESIIFGASSVDFSLSG-RLLFAGYNDYTINVWDV 312
Score = 28.9 bits (63), Expect = 8.2
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 54 IYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGY 113
++D ++ F + +N VR+ S D+ S D T + +D R RE +
Sbjct: 223 VWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY---SK 279
Query: 114 PSNIF--ISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQ 153
S IF S D + + ++ AG +D + WD S+
Sbjct: 280 ESIIFGASSVDFSLSGRLLFAGY----NDYTINVWDVLKGSR 317
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 45.4 bits (106), Expect = 8e-05
Identities = 44/177 (24%), Positives = 78/177 (44%), Gaps = 23/177 (12%)
Query: 73 LNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDI---NCNDHI 129
L+ F NS + +A DGT WD V + +Q F G+ +++ + D+ +
Sbjct: 198 LSACSFTNSDMQILTASGDGTCALWD--VESGQLLQSFHGHGADV-LCLDLAPSETGNTF 254
Query: 130 ICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSG 189
+ G +K + WD R + A+ ETH D+ VR++PS + SG
Sbjct: 255 VSGGCDKK-----AMVWDMRSGQ--------CVQAF-ETHESDINSVRYYPSG-DAFASG 299
Query: 190 SSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDL 246
S D ++D+ D E A+ + + I S + +S G + ++ +D WD+
Sbjct: 300 SDDATCRLYDLRADREV-AIYSKESIIFGASSVDFSLSG-RLLFAGYNDYTINVWDV 354
Score = 28.9 bits (63), Expect = 8.2
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 54 IYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGY 113
++D ++ F + +N VR+ S D+ S D T + +D R RE +
Sbjct: 265 VWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY---SK 321
Query: 114 PSNIF--ISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQ 153
S IF S D + + ++ AG +D + WD S+
Sbjct: 322 ESIIFGASSVDFSLSGRLLFAGY----NDYTINVWDVLKGSR 359
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 45.4 bits (106), Expect = 8e-05
Identities = 57/269 (21%), Positives = 104/269 (38%), Gaps = 47/269 (17%)
Query: 30 DTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSAC 89
DT+K + G + V V +DK +L G+ + V F S D V+SA
Sbjct: 233 DTNKILTGGADKNVVV---------FDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283
Query: 90 TDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDAR 149
D T++ W V VQ+ + + S + D+++ + DD F D
Sbjct: 284 PDATIRIWS--VPNASCVQVVRAHESAVTGLSLHATGDYLLSS-----SDDQYWAFSD-- 334
Query: 150 MNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDAL 209
+ T + ET +T +FHP + +G+ D + ++D+ E +
Sbjct: 335 -----IQTGRVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDL---KERTNV 385
Query: 210 VTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNM 269
++ I +S GY +L T + + + D+R++ N
Sbjct: 386 ANFPGHSGPITSIAFSENGY------------------YLATAADDSSVKLWDLRKLKNF 427
Query: 270 KEDALD--YLIGGLYHEKTDTLHVIGGTN 296
K LD + + L +++ T +GGT+
Sbjct: 428 KTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
Score = 30.4 bits (67), Expect = 2.8
Identities = 39/180 (21%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 169 HSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKG 228
H+ VT V FHPS ++V S S D + ++ ++ N V + S+V+ + G
Sbjct: 263 HTKKVTSVVFHPSQ-DLVFSASPDATIRIW--SVPNASCVQVVRAHE-SAVTGLSLHATG 318
Query: 229 YKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDT 288
Y ++ + YW + + T +T++ + + + D LI G
Sbjct: 319 D---YLLSSSDDQYW-AFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGT------- 367
Query: 289 LHVIGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLW 348
GT +I + + + T+V + G H+ + S ++ L T +D+ + LW
Sbjct: 368 -----GTMDSQIKIWD--LKERTNVANFPG-HSGPITSIAFSENGYYLATAADDSSVKLW 419
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 45.1 bits (105), Expect = 1e-04
Identities = 38/149 (25%), Positives = 71/149 (47%), Gaps = 19/149 (12%)
Query: 53 RIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKG 112
R++ +R LR ++G+ ++ V+F + + + + TD TV+ W A+ + V+LF G
Sbjct: 409 RLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ--QGNSVRLFTG 466
Query: 113 YPSNIF-ISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSD 171
+ + ++F N ++ AG +D L WD +L H+D
Sbjct: 467 HRGPVLSLAFSPN-GKYLASAG-----EDQRLKLWD---------LASGTLYKELRGHTD 511
Query: 172 DVTQVRFHPSNPNMVVSGSSDGLVNVFDI 200
++T + F P + ++ S S D V V+DI
Sbjct: 512 NITSLTFSPDS-GLIASASMDNSVRVWDI 539
Score = 30.0 bits (66), Expect = 3.7
Identities = 19/77 (24%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 41 NLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDAR 100
N +A ++ ++R++ ++ N +R F+G+ G + + F+ + + SA D +K WD
Sbjct: 439 NYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD-- 496
Query: 101 VAREKPVQLFKGYPSNI 117
+A + +G+ NI
Sbjct: 497 LASGTLYKELRGHTDNI 513
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 44.7 bits (104), Expect = 1e-04
Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 23/162 (14%)
Query: 60 LNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFI 119
+ V RE S + G L+ RF + +++ ++ D T WD ++K V F G+ + +
Sbjct: 133 VKVSRELSAHTGYLSCCRFLDD-NNIVTSSGDTTCALWDIETGQQKTV--FVGHTGDC-M 188
Query: 120 SFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFH 179
S ++ + ++ +G DA WD R + + T H D+ + F
Sbjct: 189 SLAVSPDFNLFISGA----CDASAKLWDVREGTCRQTFTG---------HESDINAICFF 235
Query: 180 PSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSC 221
P N + +GS D +FD+ D E C S S+ C
Sbjct: 236 P-NGEAICTGSDDASCRLFDLRADQE-----LICFSHESIIC 271
Score = 33.5 bits (75), Expect = 0.33
Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 28/194 (14%)
Query: 40 ENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDA 99
+N + + + ++D E F G+ G + + + S D + K WD
Sbjct: 154 DNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
Query: 100 RVAREKPVQLFKGYPSNIFISFDINC-----NDHIICAGTEKVDDDALLVFWDARMNSQN 154
R + Q F G+ S DIN N IC G+ DDA +D R + +
Sbjct: 214 REGTCR--QTFTGHES------DINAICFFPNGEAICTGS----DDASCRLFDLRADQEL 261
Query: 155 LSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCN 214
+ + +S+ +T V F S ++ +G D NV+D ++ +E +++
Sbjct: 262 ICFSHESIIC-------GITSVAFSLSG-RLLFAGYDDFNCNVWD-SMKSERVGILS--G 310
Query: 215 SISSVSCIGWSGKG 228
+ VSC+G + G
Sbjct: 311 HDNRVSCLGVTADG 324
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/146 (24%), Positives = 67/146 (45%), Gaps = 16/146 (10%)
Query: 66 FSGYPGLLNGVRFANSCDSVY-SACTDGTVKCWDARV-AREKPVQLFKGYPSNI-FISFD 122
F+G+ ++ V + +S++ S D + WD R KP L + + + +SF+
Sbjct: 222 FTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 281
Query: 123 INCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSN 182
++ I+ G+ D + WD R L T E+H D++ QV + P N
Sbjct: 282 -PYSEFILATGSA----DKTVALWDLRNLKLKLHTF--------ESHKDEIFQVHWSPHN 328
Query: 183 PNMVVSGSSDGLVNVFDINIDNEEDA 208
++ S +D +NV+D++ EE +
Sbjct: 329 ETILASSGTDRRLNVWDLSKIGEEQS 354
Score = 37.0 bits (84), Expect = 0.030
Identities = 47/227 (20%), Positives = 83/227 (36%), Gaps = 59/227 (25%)
Query: 137 VDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVN 196
V DD L+ WD R N+ T+K S + H+ +V + F+P + ++ +GS+D V
Sbjct: 245 VADDQKLMIWDTRSNT----TSKPS--HLVDAHTAEVNCLSFNPYSEFILATGSADKTVA 298
Query: 197 VFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVT 256
++D+ N + L T + + + WS + D WDL+ + ++
Sbjct: 299 LWDLR--NLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA- 355
Query: 257 RLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHVTSL 316
EDA D G + +
Sbjct: 356 --------------EDAED---------------------------------GPPELLFI 368
Query: 317 QGGHAATVRSFCWNVQDDSLLTG-GEDAQLLLWKPGAIEKTFTKKES 362
GGH A + F WN + ++ ED + +W+ E + +ES
Sbjct: 369 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ--MAENIYNDEES 413
Score = 31.2 bits (69), Expect = 1.7
Identities = 44/248 (17%), Positives = 86/248 (34%), Gaps = 37/248 (14%)
Query: 128 HIICAGTEKVDDDALLVFW-------DARMNSQNLSTTKDSLGAYSET-----------H 169
H + GT D+ LV DA+ ++ + + K G + H
Sbjct: 63 HWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINH 122
Query: 170 SDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVS-------CI 222
+V + R+ P NP+++ + + V VFD + CN + +
Sbjct: 123 EGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGL 182
Query: 223 GWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLY 282
W+ + + D WD+N + I D + + ++ + L
Sbjct: 183 SWNSNLSGHLLSASDDHTVCLWDINAGPKEG-----KIVDAKAIFTGHSAVVEDVAWHLL 237
Query: 283 HEKTDTLHVIGG-TNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLL-TGG 340
HE + G + ++ + + + + + L H A V +N + +L TG
Sbjct: 238 HES-----LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS 292
Query: 341 EDAQLLLW 348
D + LW
Sbjct: 293 ADKTVALW 300
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 43.9 bits (102), Expect = 2e-04
Identities = 43/182 (23%), Positives = 75/182 (41%), Gaps = 20/182 (10%)
Query: 49 NGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQ 108
+G ++++D LR+F G+ ++ V F V S D TVK WD + K +
Sbjct: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD--IPNSKEIL 158
Query: 109 LFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSET 168
FK + +D++ C K++ D L + ++ + + S S
Sbjct: 159 TFKEH------------SDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSVE 204
Query: 169 HSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKG 228
H V V PS +V +G V V+D+ + LV+ N +V+C+ S G
Sbjct: 205 HGQPVESVLLFPSGGLLVSAGGR--YVKVWDMLKGGQ--LLVSLKNHHKTVTCLCLSSSG 260
Query: 229 YK 230
+
Sbjct: 261 QR 262
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 17/133 (12%)
Query: 68 GYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCND 127
G+ G + + + ++SA TD TV WD+ V+ KG+ S + +
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGER--VKRLKGHTSFVNSCYPARRGP 164
Query: 128 HIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVV 187
++C G+ DD + WD R K ++ + T+ V V F+ ++ + ++
Sbjct: 165 QLVCTGS----DDGTVKLWDIR--------KKAAIQTFQNTY--QVLAVTFNDTS-DQII 209
Query: 188 SGSSDGLVNVFDI 200
SG D + V+D+
Sbjct: 210 SGGIDNDIKVWDL 222
Score = 42.7 bits (99), Expect = 6e-04
Identities = 34/149 (22%), Positives = 64/149 (42%), Gaps = 19/149 (12%)
Query: 49 NGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDAR--VAREKP 106
+ I+++D + + G+ + G+ ++ + S D TV+ WD R +E+
Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC 273
Query: 107 VQLFKGYPSNI---FISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLG 163
V++F+G N + + + I AG+ D + WD TT +
Sbjct: 274 VKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSA----DRFVYVWD---------TTSRRIL 320
Query: 164 AYSETHSDDVTQVRFHPSNPNMVVSGSSD 192
H+ + +V FHP P +++S SSD
Sbjct: 321 YKLPGHAGSINEVAFHPDEP-IIISASSD 348
Score = 35.8 bits (81), Expect = 0.067
Identities = 45/245 (18%), Positives = 90/245 (36%), Gaps = 38/245 (15%)
Query: 104 EKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLG 163
+ P+ L G+ ++ C H + D L++ W+ + N +T K G
Sbjct: 56 QAPIMLLSGHEGEVYC-----CKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110
Query: 164 AYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIG 223
A E H + ++ +M+ S S+D V V+D L + ++S
Sbjct: 111 AVMELH---------YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC---- 157
Query: 224 WSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYH 283
+ + Q+ C D+G + + D+R+ ++ Y + +
Sbjct: 158 YPARRGPQLVCTGSDDG----------------TVKLWDIRKKAAIQTFQNTYQVLAVTF 201
Query: 284 EKTDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDA 343
T + GG + I + + + LT+ GHA +V + + LL+ D
Sbjct: 202 NDTSDQIISGGIDND-IKVWDLRQNKLTYT---MRGHADSVTGLSLSSEGSYLLSNAMDN 257
Query: 344 QLLLW 348
+ +W
Sbjct: 258 TVRVW 262
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 43.5 bits (101), Expect = 3e-04
Identities = 34/158 (21%), Positives = 63/158 (39%), Gaps = 17/158 (10%)
Query: 43 VAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVA 102
+A + SI+++ R L + + +F+ + S D T+K WD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
Query: 103 REKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSL 162
Q + ++ + ++ N C + D + WD R+N L
Sbjct: 177 -----QCVNNFSDSVGFANFVDFNPSGTCIAS--AGSDQTVKVWDVRVNK---------L 220
Query: 163 GAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDI 200
+ + HS V + FHPS N +++ SSDG + + D+
Sbjct: 221 LQHYQVHSGGVNCISFHPSG-NYLITASSDGTLKILDL 257
>gi|14149987 WD repeat domain 24 [Homo sapiens]
Length = 790
Score = 43.1 bits (100), Expect = 4e-04
Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 24/214 (11%)
Query: 40 ENLVAVLCSNGSIRIYDKERLNVLRE---FSGYPGLLNGVRF-ANSCDSVYSACTDGTVK 95
ENL+A +NG + ++ R + ++ F+ + +N V F + S DG +K
Sbjct: 87 ENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMK 146
Query: 96 CWDARVAREKPVQLFKGYPSNIF-ISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQN 154
C+D R R+ V F G ++ + F I D+ A T ++ + WD R
Sbjct: 147 CFDLR--RKDSVSTFSGQSESVRDVQFSIR--DYFTFASTF---ENGNVQLWDIRR---- 195
Query: 155 LSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCN 214
D H+ V +HP + + +G D +V V+D+ ++ +
Sbjct: 196 ----PDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKE--MHCVQ 249
Query: 215 SISSVSCIGW--SGKGYKQIYCMTHDEGFYWWDL 246
+I+SV+ + W + + M D Y WD+
Sbjct: 250 TIASVARVKWRPECRHHLATCSMMVDHNIYVWDV 283
Score = 40.4 bits (93), Expect = 0.003
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 9/114 (7%)
Query: 140 DALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFD 199
+ ++V W+ S+N +D L ++E H V +V FHP+ ++++SGS DG + FD
Sbjct: 96 NGVVVTWNLGRPSRN---KQDQL--FTE-HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFD 149
Query: 200 INIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDE 253
+ +D++ T SV + +S + Y + WD+ D E
Sbjct: 150 L---RRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCE 200
Score = 32.7 bits (73), Expect = 0.57
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 12/103 (11%)
Query: 91 DGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARM 150
D VK WD R K + + S + + C H+ T + D + WD R
Sbjct: 229 DKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHL---ATCSMMVDHNIYVWDVRR 285
Query: 151 NSQNLSTTKDSLGAYSETHSDDVTQVRF-HPSNPNMVVSGSSD 192
A E H D T + + HP +P+ ++SGS D
Sbjct: 286 PFVP--------AAMFEEHRDVTTGIAWRHPHDPSFLLSGSKD 320
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 42.7 bits (99), Expect = 6e-04
Identities = 64/297 (21%), Positives = 110/297 (37%), Gaps = 42/297 (14%)
Query: 53 RIYDKERLNVLREFSGYPGLLNGVRFANSC-DSVYSACTDGTVKCWDARVAREKPVQLFK 111
+++D L G+ ++ + F N D + + D T K W K F+
Sbjct: 117 KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG--KCYHTFR 174
Query: 112 GYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSD 171
G+ + I + N ++ G+ D WD + N + + T + HS
Sbjct: 175 GHTAEI-VCLSFNPQSTLVATGSM----DTTAKLWDIQ-NGEEVYTLRG--------HSA 220
Query: 172 DVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQ 231
++ + F+ S + +++GS D V V+D + + + L+ C ISS S W
Sbjct: 221 EIISLSFNTSG-DRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS-FNWD---CSL 275
Query: 232 IYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHV 291
I + D+ WD N + V + ++ LD Y K
Sbjct: 276 ILTGSMDKTCKLWDAT-----------NGKCVATLTGHDDEILDSCFD--YTGKLIATAS 322
Query: 292 IGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLW 348
GT RI S + + L+ GH + +N Q + LLTG D +W
Sbjct: 323 ADGT--ARIF----SAATRKCIAKLE-GHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 37.7 bits (86), Expect = 0.018
Identities = 21/94 (22%), Positives = 47/94 (50%), Gaps = 3/94 (3%)
Query: 42 LVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARV 101
L+A ++G+ RI+ + + G+ G ++ + F + + + +D T + WDA+
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
Query: 102 AREKPVQLFKGYPSNIFISFDINCNDHIICAGTE 135
+ +Q+ +G+ IF S N +I+ G++
Sbjct: 377 G--QCLQVLEGHTDEIF-SCAFNYKGNIVITGSK 407
>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
sapiens]
Length = 731
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/192 (20%), Positives = 75/192 (39%), Gaps = 30/192 (15%)
Query: 72 LLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIIC 131
+++ + F CD A +K ++ + V + YP N ++ CN I C
Sbjct: 423 IVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIH--YPEN-----EMTCNSKISC 475
Query: 132 AGTEKV--------DDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNP 183
D + ++ WD ++ Y E H V F+ +P
Sbjct: 476 ISWSSYHKNLLASSDYEGTVILWDGFTGQRSK--------VYQE-HEKRCWSVDFNLMDP 526
Query: 184 NMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYW 243
++ SGS D V ++ N+DN V + + ++V C+ +S + D ++
Sbjct: 527 KLLASGSDDAKVKLWSTNLDNS----VASIEAKANVCCVKFSPSSRYHLAFGCADHCVHY 582
Query: 244 WDLNHLDTDEPV 255
+DL +T +P+
Sbjct: 583 YDLR--NTKQPI 592
>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
sapiens]
Length = 707
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/192 (20%), Positives = 75/192 (39%), Gaps = 30/192 (15%)
Query: 72 LLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIIC 131
+++ + F CD A +K ++ + V + YP N ++ CN I C
Sbjct: 399 IVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIH--YPEN-----EMTCNSKISC 451
Query: 132 AGTEKV--------DDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNP 183
D + ++ WD ++ Y E H V F+ +P
Sbjct: 452 ISWSSYHKNLLASSDYEGTVILWDGFTGQRSK--------VYQE-HEKRCWSVDFNLMDP 502
Query: 184 NMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYW 243
++ SGS D V ++ N+DN V + + ++V C+ +S + D ++
Sbjct: 503 KLLASGSDDAKVKLWSTNLDNS----VASIEAKANVCCVKFSPSSRYHLAFGCADHCVHY 558
Query: 244 WDLNHLDTDEPV 255
+DL +T +P+
Sbjct: 559 YDLR--NTKQPI 568
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/146 (24%), Positives = 68/146 (46%), Gaps = 16/146 (10%)
Query: 66 FSGYPGLLNGVRFANSCDSVY-SACTDGTVKCWDARVAR-EKPVQLFKGYPSNI-FISFD 122
F+G+ ++ V + +S++ S D + WD R KP + + + +SF+
Sbjct: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 247
Query: 123 INCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSN 182
++ I+ G+ D + WD R NL S E+H D++ QV++ P N
Sbjct: 248 -PYSEFILATGSA----DKTVALWDLR----NLKLKLHSF----ESHKDEIFQVQWSPHN 294
Query: 183 PNMVVSGSSDGLVNVFDINIDNEEDA 208
++ S +D +NV+D++ EE +
Sbjct: 295 ETILASSGTDRRLNVWDLSKIGEEQS 320
Score = 35.8 bits (81), Expect = 0.067
Identities = 57/277 (20%), Positives = 104/277 (37%), Gaps = 68/277 (24%)
Query: 80 NSCDSVYSACTDGTVKCWD-ARVAREKPV----QLFKGYPSNIFISFDINCNDHIICAGT 134
N + SA D T+ WD + V +E V +F G+ + + D++ H++
Sbjct: 153 NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA---VVEDVSW--HLLHESL 207
Query: 135 -EKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDG 193
V DD L+ WD R N+ T+K S + H+ +V + F+P + ++ +GS+D
Sbjct: 208 FGSVADDQKLMIWDTRSNN----TSKPSHSV--DAHTAEVNCLSFNPYSEFILATGSADK 261
Query: 194 LVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDE 253
V ++D+ N + L + + + + WS + D WDL+ + ++
Sbjct: 262 TVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 319
Query: 254 PVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHV 313
EDA D G +
Sbjct: 320 S---------------PEDAED---------------------------------GPPEL 331
Query: 314 TSLQGGHAATVRSFCWNVQDDSLLTG-GEDAQLLLWK 349
+ GGH A + F WN + ++ ED + +W+
Sbjct: 332 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 368
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/146 (24%), Positives = 68/146 (46%), Gaps = 16/146 (10%)
Query: 66 FSGYPGLLNGVRFANSCDSVY-SACTDGTVKCWDARVAR-EKPVQLFKGYPSNI-FISFD 122
F+G+ ++ V + +S++ S D + WD R KP + + + +SF+
Sbjct: 222 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 281
Query: 123 INCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSN 182
++ I+ G+ D + WD R NL S E+H D++ QV++ P N
Sbjct: 282 -PYSEFILATGSA----DKTVALWDLR----NLKLKLHSF----ESHKDEIFQVQWSPHN 328
Query: 183 PNMVVSGSSDGLVNVFDINIDNEEDA 208
++ S +D +NV+D++ EE +
Sbjct: 329 ETILASSGTDRRLNVWDLSKIGEEQS 354
Score = 35.8 bits (81), Expect = 0.067
Identities = 57/277 (20%), Positives = 104/277 (37%), Gaps = 68/277 (24%)
Query: 80 NSCDSVYSACTDGTVKCWD-ARVAREKPV----QLFKGYPSNIFISFDINCNDHIICAGT 134
N + SA D T+ WD + V +E V +F G+ + + D++ H++
Sbjct: 187 NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA---VVEDVSW--HLLHESL 241
Query: 135 -EKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDG 193
V DD L+ WD R N+ T+K S + H+ +V + F+P + ++ +GS+D
Sbjct: 242 FGSVADDQKLMIWDTRSNN----TSKPSHSV--DAHTAEVNCLSFNPYSEFILATGSADK 295
Query: 194 LVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDE 253
V ++D+ N + L + + + + WS + D WDL+ + ++
Sbjct: 296 TVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 353
Query: 254 PVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHV 313
EDA D G +
Sbjct: 354 S---------------PEDAED---------------------------------GPPEL 365
Query: 314 TSLQGGHAATVRSFCWNVQDDSLLTG-GEDAQLLLWK 349
+ GGH A + F WN + ++ ED + +W+
Sbjct: 366 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 402
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/146 (24%), Positives = 68/146 (46%), Gaps = 16/146 (10%)
Query: 66 FSGYPGLLNGVRFANSCDSVY-SACTDGTVKCWDARVAR-EKPVQLFKGYPSNI-FISFD 122
F+G+ ++ V + +S++ S D + WD R KP + + + +SF+
Sbjct: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282
Query: 123 INCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSN 182
++ I+ G+ D + WD R NL S E+H D++ QV++ P N
Sbjct: 283 -PYSEFILATGSA----DKTVALWDLR----NLKLKLHSF----ESHKDEIFQVQWSPHN 329
Query: 183 PNMVVSGSSDGLVNVFDINIDNEEDA 208
++ S +D +NV+D++ EE +
Sbjct: 330 ETILASSGTDRRLNVWDLSKIGEEQS 355
Score = 35.8 bits (81), Expect = 0.067
Identities = 57/277 (20%), Positives = 104/277 (37%), Gaps = 68/277 (24%)
Query: 80 NSCDSVYSACTDGTVKCWD-ARVAREKPV----QLFKGYPSNIFISFDINCNDHIICAGT 134
N + SA D T+ WD + V +E V +F G+ + + D++ H++
Sbjct: 188 NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA---VVEDVSW--HLLHESL 242
Query: 135 -EKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDG 193
V DD L+ WD R N+ T+K S + H+ +V + F+P + ++ +GS+D
Sbjct: 243 FGSVADDQKLMIWDTRSNN----TSKPSHSV--DAHTAEVNCLSFNPYSEFILATGSADK 296
Query: 194 LVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDE 253
V ++D+ N + L + + + + WS + D WDL+ + ++
Sbjct: 297 TVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354
Query: 254 PVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHV 313
EDA D G +
Sbjct: 355 S---------------PEDAED---------------------------------GPPEL 366
Query: 314 TSLQGGHAATVRSFCWNVQDDSLLTG-GEDAQLLLWK 349
+ GGH A + F WN + ++ ED + +W+
Sbjct: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,751,593
Number of Sequences: 37866
Number of extensions: 638156
Number of successful extensions: 2249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 1698
Number of HSP's gapped (non-prelim): 616
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.