Guide to the Human Genome
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Search of human proteins with 17981702

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
         (166 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]        324   2e-89
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]       324   2e-89
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]       132   2e-31
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]        132   2e-31
gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo...   103   7e-23
gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo ...   102   2e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         89   2e-18
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        84   6e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         84   6e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         84   6e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        79   1e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         79   1e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         79   1e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         79   1e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         79   1e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   72   2e-13
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1...    72   2e-13
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    72   3e-13
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    71   5e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    70   6e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    70   8e-13
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]           70   1e-12
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  68   4e-12
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         68   4e-12
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         68   4e-12
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]         68   4e-12
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         68   4e-12
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]         68   4e-12
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]         68   4e-12
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]              68   4e-12

>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
          Length = 166

 Score =  324 bits (830), Expect = 2e-89
 Identities = 166/166 (100%), Positives = 166/166 (100%)

Query: 1   MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
           MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
Sbjct: 1   MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60

Query: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
           LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
Sbjct: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120

Query: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
           AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
Sbjct: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166


>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
          Length = 166

 Score =  324 bits (830), Expect = 2e-89
 Identities = 166/166 (100%), Positives = 166/166 (100%)

Query: 1   MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60
           MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
Sbjct: 1   MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL 60

Query: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
           LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
Sbjct: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120

Query: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
           AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
Sbjct: 121 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166


>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
          Length = 168

 Score =  132 bits (331), Expect = 2e-31
 Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)

Query: 9   GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
           G+ L+ AAARGD++++  LL    V+ +A N FG+TALQVM  G+  IA  LL +GA+P+
Sbjct: 6   GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64

Query: 69  VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
           ++D +G + +HDAAR GFLDTL+ L+E  ADVN+ D  G LP+HLA +EGH  VV FL  
Sbjct: 65  LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124

Query: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
              S++  R+ +G T  +LA   G  ++V ++Q +
Sbjct: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159


>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
          Length = 168

 Score =  132 bits (331), Expect = 2e-31
 Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)

Query: 9   GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
           G+ L+ AAARGD++++  LL    V+ +A N FG+TALQVM  G+  IA  LL +GA+P+
Sbjct: 6   GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64

Query: 69  VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
           ++D +G + +HDAAR GFLDTL+ L+E  ADVN+ D  G LP+HLA +EGH  VV FL  
Sbjct: 65  LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124

Query: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
              S++  R+ +G T  +LA   G  ++V ++Q +
Sbjct: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159


>gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo
           sapiens]
          Length = 138

 Score =  103 bits (257), Expect = 7e-23
 Identities = 60/116 (51%), Positives = 75/116 (64%), Gaps = 2/116 (1%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
           L+ AAARG V++VR+LL      P+ +NRFG+ A+QVMM GS  +A  LL  GA PN  D
Sbjct: 18  LASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCAD 76

Query: 72  TSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +  T PVHDAAR GFLDTL VL   GA ++V D  G LP+ LA + GH  V  +L
Sbjct: 77  PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132


>gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
           sapiens]
          Length = 156

 Score =  102 bits (253), Expect = 2e-22
 Identities = 66/150 (44%), Positives = 84/150 (56%), Gaps = 6/150 (4%)

Query: 8   AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASP 67
           + D L+ AAARG V+EVR LL    + P+A N +G+  +QVMM GS  +A  LL  GA P
Sbjct: 12  SADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARVAELLLLHGAEP 70

Query: 68  NVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           N  D +  T PVHDAAR GFLDTL VL   GA ++V D  G LP+ LA + GH  V  +L
Sbjct: 71  NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130

Query: 127 AAESDLHRRDARGLTPLELALQRGAQDLVD 156
            A +       RG     +    G  D+ D
Sbjct: 131 RAAAG----GTRGSNHARIDAAEGPSDIPD 156


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 88.6 bits (218), Expect = 2e-18
 Identities = 54/145 (37%), Positives = 80/145 (55%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+    EV  LL ++   PDA  + G T L V   + +  +AL LL QGASP+    +G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLH 133
            +P+H AA+   +D    L+E+GAD N     G   +HLA QEGH  +VS  L   ++++
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             +  GLTPL LA Q    ++ ++L
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVL 716



 Score = 73.9 bits (180), Expect = 6e-14
 Identities = 51/159 (32%), Positives = 77/159 (48%), Gaps = 2/159 (1%)

Query: 9   GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASP 67
           G+     AAR    EV R L ++    +A  +  +T L +    G   I  +LL+QGASP
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525

Query: 68  NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA 127
           N   TSG +P+H +AR G  D    L++HGA +++    G  P+H+A + G   V + L 
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585

Query: 128 AES-DLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +S         GLTPL +A     Q +  +L     +P
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624



 Score = 67.4 bits (163), Expect = 5e-12
 Identities = 40/110 (36%), Positives = 59/110 (53%), Gaps = 5/110 (4%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           G   +  ELL++ A+ +     G + +H A+  G  + +KVLV +GA+VN     G  P+
Sbjct: 85  GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144

Query: 112 HLAVQEGHTAVVSFL---AAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
           ++A QE H  VV FL    A   L   D  G TPL +ALQ+G   +V +L
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLL 192



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           A +GD     +LL +  V  D +     TAL V    G   +A  LL + A+PN +  +G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A +   +  +++L++HGA +     +G  PIH+A   GH  +VS L    +  +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + RG T L +A + G  ++V  L
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYL 485



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 2/150 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D  +   LL +   + D  ++ G T L +   +G+  +A  LL + A+ +    + 
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDLH 133
            +P+H A++ G  + +K+L++ GA ++     G  P+H   + GH  VV  L    + + 
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMV 163
            +   GL+PL +A Q    + V +L  H V
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358



 Score = 59.3 bits (142), Expect = 1e-09
 Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 2/145 (1%)

Query: 23  EVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDA 81
           +V ++L  +  +P+A    G T L +    +    +ELL K GAS      SG +P+H A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440

Query: 82  ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
           A  G ++ +  L+ HGA  N  +  G   +H+A + G   VV +L  + + +  +     
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500

Query: 141 TPLELALQRGAQDLVDILQGHMVAP 165
           TPL ++ + G  D+V  L     +P
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASP 525



 Score = 58.9 bits (141), Expect = 2e-09
 Identities = 44/147 (29%), Positives = 68/147 (46%), Gaps = 3/147 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V  V  LL R   + +  N+ G T L +        +A  L+ QGA  + Q   
Sbjct: 671 AAQEGHVDMVSLLLGRN-ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H     G +  +  L++H A VN     G  P+H A Q+GHT +++  L   +  
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQ 159
           +     G T L +A + G   +VD L+
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTLK 816



 Score = 50.8 bits (120), Expect = 5e-07
 Identities = 40/149 (26%), Positives = 71/149 (47%), Gaps = 3/149 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDT-S 73
           A+ RG+   V+ LL R     DA  R G T L           +E+L   A+P +  T +
Sbjct: 275 ASKRGNANMVKLLLDRG-AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G SP+H A +   L+ +++L++H   V+         +H+A   GH  V    L  +++ 
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGH 161
           + +   G TPL +A ++    ++++L  H
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKH 422



 Score = 48.1 bits (113), Expect = 3e-06
 Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 1/79 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRDARG 139
           AAR G L+     +++G D+N+ +  G   +HLA +EGH  VVS  L  E+++     +G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 140 LTPLELALQRGAQDLVDIL 158
            T L +A   G  ++V +L
Sbjct: 108 NTALHIASLAGQAEVVKVL 126



 Score = 37.4 bits (85), Expect = 0.006
 Identities = 25/84 (29%), Positives = 44/84 (52%), Gaps = 5/84 (5%)

Query: 78  VHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAESDLHR 134
           +H AAR        +L+++  + +V   +G  P+H+A   G+  V + L   AA  D   
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265

Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
           R+   +TPL +A +RG  ++V +L
Sbjct: 266 RN--DITPLHVASKRGNANMVKLL 287


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 84.0 bits (206), Expect = 6e-17
 Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+    +V +LL +     D+  + G T L V   + +  +AL LL++GASP+    +G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H AA+   +     L+ +GA+ N+    G  P+HLA QEGHT +V+ L  + +++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
                GLT L LA Q    ++ DIL  H
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKH 696



 Score = 65.9 bits (159), Expect = 2e-11
 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA  G++ +V   L +  +  +  N+ G  AL +    G   +  ELL +G+S +     
Sbjct: 17  AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
           G + +H A+  G  + +KVLV+ GA++N     G  P+++A QE H  VV +L  E+  +
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 134

Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
           +  A   G TPL +ALQ+G    V IL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAIL 161



 Score = 62.8 bits (151), Expect = 1e-10
 Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)

Query: 6   VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
           +R    L  AA  G V+ VR LL    +  DA  R  +T L +    G T I   LL+  
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 499

Query: 65  ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
           A P+   T+G +P+H +AR G +D   VL+E GA  ++    G  P+H+A + G   V  
Sbjct: 500 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559

Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
            L     L RR A       GLTPL +A     Q +  +L
Sbjct: 560 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
           V +LL  +  +P+A    G T L +    +    +ELL K GAS      SG +P+H AA
Sbjct: 359 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 418

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
             G L+ + +L+++GA  +V +  G   +H+A + G   VV  L     L    AR   T
Sbjct: 419 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 478

Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
           PL +A + G  ++V +L  HM  P
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHP 502



 Score = 61.6 bits (148), Expect = 3e-10
 Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)

Query: 23  EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
           +V  LL +      A+   G T + V  F G   I L LL+ GASP+V +  G + +H A
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450

Query: 82  ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
           AR G ++ ++ L+ +GA V+        P+H+A + G T +V  L    +        G 
Sbjct: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510

Query: 141 TPLELALQRGAQDLVDIL 158
           TPL ++ + G  D+  +L
Sbjct: 511 TPLHISAREGQVDVASVL 528



 Score = 60.1 bits (144), Expect = 9e-10
 Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
           +G+  +A  LL +GA+ +    +G +P+H A++ G  + +K+L++ G  ++     G  P
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281

Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
           +H A + GH  VV  L    + L  R   GL+PL +A Q    + V  L  H
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333



 Score = 58.5 bits (140), Expect = 2e-09
 Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+ D   V  +L +     DA  + G T L V   +G+  +   LLKQGA+ N +  +G
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +P+H AA+ G    + VL++HGA  N     G   + +A + G+ +VV  L
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 57.8 bits (138), Expect = 4e-09
 Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           G T +   LL +GA+ ++   SG + +H AA+   ++   +L +HGAD +     G  P+
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 711

Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +A   G+  +V+FL  + ++++ +   G TPL  A Q+G   ++++L  H   P
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766



 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)

Query: 16  AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA+GD V+ V+ LL  +    D    +  TAL V    G   +   LL + A+PN +  +
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 376

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
           G +P+H A +   +  +++LV++GA +     +G  PIH+A   GH  +V  L    A  
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
           D+   + RG T L +A + G  ++V  L
Sbjct: 437 DV--TNIRGETALHMAARAGQVEVVRCL 462



 Score = 50.8 bits (120), Expect = 5e-07
 Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
           SG +P+H AA  G ++   +L+  GA V+     G  P+H+A + G+T +V  L     +
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270

Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
            D   RD  GLTPL  A + G   +V++L
Sbjct: 271 IDAKTRD--GLTPLHCAARSGHDQVVELL 297



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
           A+ RG+   V+ LL R     DA  R G T L      G   +   LL++GA    +  +
Sbjct: 252 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
           G SP+H AA+   ++ +K L++H A V+         +H+A   GH  V   L    ++ 
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R   G TPL +A ++    ++++L
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELL 396



 Score = 36.6 bits (83), Expect = 0.010
 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)

Query: 19  GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
           G+V+ V  LL ++  + +A  + G T L Q    G T I   LL+ GA PN    +G + 
Sbjct: 718 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776

Query: 78  VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           +  A R G++   DTLKV+ E   +V     T      L V E  T V+     E D
Sbjct: 777 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 830


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 84.0 bits (206), Expect = 6e-17
 Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+    +V +LL +     D+  + G T L V   + +  +AL LL++GASP+    +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H AA+   +     L+ +GA+ N+    G  P+HLA QEGHT +V+ L  + +++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
                GLT L LA Q    ++ DIL  H
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKH 717



 Score = 65.9 bits (159), Expect = 2e-11
 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA  G++ +V   L +  +  +  N+ G  AL +    G   +  ELL +G+S +     
Sbjct: 38  AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
           G + +H A+  G  + +KVLV+ GA++N     G  P+++A QE H  VV +L  E+  +
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 155

Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
           +  A   G TPL +ALQ+G    V IL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAIL 182



 Score = 62.8 bits (151), Expect = 1e-10
 Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)

Query: 6   VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
           +R    L  AA  G V+ VR LL    +  DA  R  +T L +    G T I   LL+  
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 65  ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
           A P+   T+G +P+H +AR G +D   VL+E GA  ++    G  P+H+A + G   V  
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
            L     L RR A       GLTPL +A     Q +  +L
Sbjct: 581 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
           V +LL  +  +P+A    G T L +    +    +ELL K GAS      SG +P+H AA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
             G L+ + +L+++GA  +V +  G   +H+A + G   VV  L     L    AR   T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499

Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
           PL +A + G  ++V +L  HM  P
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHP 523



 Score = 61.6 bits (148), Expect = 3e-10
 Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)

Query: 23  EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
           +V  LL +      A+   G T + V  F G   I L LL+ GASP+V +  G + +H A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471

Query: 82  ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
           AR G ++ ++ L+ +GA V+        P+H+A + G T +V  L    +        G 
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531

Query: 141 TPLELALQRGAQDLVDIL 158
           TPL ++ + G  D+  +L
Sbjct: 532 TPLHISAREGQVDVASVL 549



 Score = 60.1 bits (144), Expect = 9e-10
 Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
           +G+  +A  LL +GA+ +    +G +P+H A++ G  + +K+L++ G  ++     G  P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302

Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
           +H A + GH  VV  L    + L  R   GL+PL +A Q    + V  L  H
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354



 Score = 58.5 bits (140), Expect = 2e-09
 Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+ D   V  +L +     DA  + G T L V   +G+  +   LLKQGA+ N +  +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +P+H AA+ G    + VL++HGA  N     G   + +A + G+ +VV  L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 57.8 bits (138), Expect = 4e-09
 Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           G T +   LL +GA+ ++   SG + +H AA+   ++   +L +HGAD +     G  P+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732

Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +A   G+  +V+FL  + ++++ +   G TPL  A Q+G   ++++L  H   P
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)

Query: 16  AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA+GD V+ V+ LL  +    D    +  TAL V    G   +   LL + A+PN +  +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
           G +P+H A +   +  +++LV++GA +     +G  PIH+A   GH  +V  L    A  
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
           D+   + RG T L +A + G  ++V  L
Sbjct: 458 DV--TNIRGETALHMAARAGQVEVVRCL 483



 Score = 50.8 bits (120), Expect = 5e-07
 Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
           SG +P+H AA  G ++   +L+  GA V+     G  P+H+A + G+T +V  L     +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291

Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
            D   RD  GLTPL  A + G   +V++L
Sbjct: 292 IDAKTRD--GLTPLHCAARSGHDQVVELL 318



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
           A+ RG+   V+ LL R     DA  R G T L      G   +   LL++GA    +  +
Sbjct: 273 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
           G SP+H AA+   ++ +K L++H A V+         +H+A   GH  V   L    ++ 
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R   G TPL +A ++    ++++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELL 417



 Score = 36.6 bits (83), Expect = 0.010
 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)

Query: 19  GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
           G+V+ V  LL ++  + +A  + G T L Q    G T I   LL+ GA PN    +G + 
Sbjct: 739 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797

Query: 78  VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           +  A R G++   DTLKV+ E   +V     T      L V E  T V+     E D
Sbjct: 798 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 84.0 bits (206), Expect = 6e-17
 Identities = 51/148 (34%), Positives = 81/148 (54%), Gaps = 2/148 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+    +V +LL +     D+  + G T L V   + +  +AL LL++GASP+    +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H AA+   +     L+ +GA+ N+    G  P+HLA QEGHT +V+ L  + +++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGH 161
                GLT L LA Q    ++ DIL  H
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKH 717



 Score = 65.9 bits (159), Expect = 2e-11
 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 5/147 (3%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA  G++ +V   L +  +  +  N+ G  AL +    G   +  ELL +G+S +     
Sbjct: 38  AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLH 133
           G + +H A+  G  + +KVLV+ GA++N     G  P+++A QE H  VV +L  E+  +
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGAN 155

Query: 134 RRDAR--GLTPLELALQRGAQDLVDIL 158
           +  A   G TPL +ALQ+G    V IL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAIL 182



 Score = 62.8 bits (151), Expect = 1e-10
 Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 13/160 (8%)

Query: 6   VRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQG 64
           +R    L  AA  G V+ VR LL    +  DA  R  +T L +    G T I   LL+  
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 65  ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS 124
           A P+   T+G +P+H +AR G +D   VL+E GA  ++    G  P+H+A + G   V  
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 125 FLAAESDLHRRDA------RGLTPLELALQRGAQDLVDIL 158
            L     L RR A       GLTPL +A     Q +  +L
Sbjct: 581 LL-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 47/144 (32%), Positives = 72/144 (50%), Gaps = 2/144 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAA 82
           V +LL  +  +P+A    G T L +    +    +ELL K GAS      SG +P+H AA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARG-LT 141
             G L+ + +L+++GA  +V +  G   +H+A + G   VV  L     L    AR   T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499

Query: 142 PLELALQRGAQDLVDILQGHMVAP 165
           PL +A + G  ++V +L  HM  P
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHP 523



 Score = 61.6 bits (148), Expect = 3e-10
 Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 2/138 (1%)

Query: 23  EVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA 81
           +V  LL +      A+   G T + V  F G   I L LL+ GASP+V +  G + +H A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471

Query: 82  ARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGL 140
           AR G ++ ++ L+ +GA V+        P+H+A + G T +V  L    +        G 
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531

Query: 141 TPLELALQRGAQDLVDIL 158
           TPL ++ + G  D+  +L
Sbjct: 532 TPLHISAREGQVDVASVL 549



 Score = 60.1 bits (144), Expect = 9e-10
 Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
           +G+  +A  LL +GA+ +    +G +P+H A++ G  + +K+L++ G  ++     G  P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302

Query: 111 IHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
           +H A + GH  VV  L    + L  R   GL+PL +A Q    + V  L  H
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354



 Score = 58.5 bits (140), Expect = 2e-09
 Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AA+ D   V  +L +     DA  + G T L V   +G+  +   LLKQGA+ N +  +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +P+H AA+ G    + VL++HGA  N     G   + +A + G+ +VV  L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 57.8 bits (138), Expect = 4e-09
 Identities = 33/115 (28%), Positives = 62/115 (53%), Gaps = 1/115 (0%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           G T +   LL +GA+ ++   SG + +H AA+   ++   +L +HGAD +     G  P+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPL 732

Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +A   G+  +V+FL  + ++++ +   G TPL  A Q+G   ++++L  H   P
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 8/148 (5%)

Query: 16  AARGD-VQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTS 73
           AA+GD V+ V+ LL  +    D    +  TAL V    G   +   LL + A+PN +  +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAES 130
           G +P+H A +   +  +++LV++GA +     +G  PIH+A   GH  +V  L    A  
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 131 DLHRRDARGLTPLELALQRGAQDLVDIL 158
           D+   + RG T L +A + G  ++V  L
Sbjct: 458 DV--TNIRGETALHMAARAGQVEVVRCL 483



 Score = 50.8 bits (120), Expect = 5e-07
 Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL---AAE 129
           SG +P+H AA  G ++   +L+  GA V+     G  P+H+A + G+T +V  L     +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291

Query: 130 SDLHRRDARGLTPLELALQRGAQDLVDIL 158
            D   RD  GLTPL  A + G   +V++L
Sbjct: 292 IDAKTRD--GLTPLHCAARSGHDQVVELL 318



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTS 73
           A+ RG+   V+ LL R     DA  R G T L      G   +   LL++GA    +  +
Sbjct: 273 ASKRGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDL 132
           G SP+H AA+   ++ +K L++H A V+         +H+A   GH  V   L    ++ 
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R   G TPL +A ++    ++++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELL 417



 Score = 36.6 bits (83), Expect = 0.010
 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 8/117 (6%)

Query: 19  GDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSP 77
           G+V+ V  LL ++  + +A  + G T L Q    G T I   LL+ GA PN    +G + 
Sbjct: 739 GNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797

Query: 78  VHDAARTGFL---DTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           +  A R G++   DTLKV+ E   +V     T      L V E  T V+     E D
Sbjct: 798 LAIAKRLGYISVVDTLKVVTE---EVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 79.3 bits (194), Expect = 1e-15
 Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V+    LL R+  HP+A  + G T L V +  +   I   LL +G SP+    +
Sbjct: 576 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 634

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H AA+   ++  + L+++G   N     G  P+HLA QEGH  +V+  L+ +++ 
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
           +  +  GLTPL L  Q G   + D+L  H V
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
           A+  G V+ V  LLH+E++  +   + G TAL +  + G   +  EL+  GA+ N Q   
Sbjct: 85  ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           G +P++ AA+   L+ +K L+E+GA+ NV    G  P+ +A+Q+GH  VV+ L
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196



 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 4   EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
           E V+    L  AA  G  + V  LL ++  + +  N+ G T L  V   G   +A  L+K
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 63  QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
            G   +     G +P+H A+  G +  +K L++H ADVN     G  P+H A Q+GHT +
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782

Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
           V+ L    +  +   + G TPL +A + G   + D+L+
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820



 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  LL +     DA+   G T L V  F G   I   LL++GASPNV +    +P+H AA
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
           R G  +  K L+++ A VN        P+H A + GHT +V  L    ++ +     G T
Sbjct: 479 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538

Query: 142 PLELALQRGAQDLV 155
           PL +A + G  + V
Sbjct: 539 PLHIAAREGHVETV 552



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D      +L +   +PD L++ G T L +   + +  +A  LL +GAS N    +G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A+R G +  +++L++ GA +         P+H A + GH  +   L    + + 
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +   GL+P+ +A Q    D V +L
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLL 357



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
           AAR    EV + L +     +A  +  +T L      G T +   LL+  A+PN+  T+G
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
            +P+H AAR G ++T+  L+E  A        G  P+H+A + G   V   L  E D H 
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 595

Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
             A   GLTPL +A+     D+V +L
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLL 621



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV R L +     +A +  G T L +    G   +   LL + A+ N+ + SG
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
            +P+H  A+ G +    VL++HG  V+     G  P+H+A   G+  +V FL   ++D++
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +   G +PL  A Q+G  D+V +L  +  +P
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793



 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           AA+GD  +  RLL +     D +     T L V    G   +A  LL +GA PN +  +G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
            +P+H A +   +  +++L++ GA ++    +G  P+H+A   GH  +V + L   +  +
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + +  TPL +A + G  ++   L
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYL 489



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  +L +  V  DA  R G T L V   +G+  +   LL+  A  N +   G SP+H AA
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           + G  D + +L+++GA  N     G  P+ +A + G+ +V   L   +D
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
           AAR+G LD     + +G D+N  +  G   +HLA +EGH   VV  L  E  L     +G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 140 LTPLELALQRGAQDLV 155
            T L +A   G  ++V
Sbjct: 112 NTALHIAALAGQDEVV 127



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV + L     + +     G T L V +  G   +   L+  G    V+    
Sbjct: 151 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 206

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
              +H AAR     T  VL+++  + +V   TG  P+H+A    +  V   L    + ++
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
                G+TPL +A +RG   +V +L
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLL 291


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 79.3 bits (194), Expect = 1e-15
 Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V+    LL R+  HP+A  + G T L V +  +   I   LL +G SP+    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H AA+   ++  + L+++G   N     G  P+HLA QEGH  +V+  L+ +++ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
           +  +  GLTPL L  Q G   + D+L  H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
           A+  G V+ V  LLH+E++  +   + G TAL +  + G   +  EL+  GA+ N Q   
Sbjct: 52  ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           G +P++ AA+   L+ +K L+E+GA+ NV    G  P+ +A+Q+GH  VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 4   EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
           E V+    L  AA  G  + V  LL ++  + +  N+ G T L  V   G   +A  L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 63  QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
            G   +     G +P+H A+  G +  +K L++H ADVN     G  P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
           V+ L    +  +   + G TPL +A + G   + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  LL +     DA+   G T L V  F G   I   LL++GASPNV +    +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
           R G  +  K L+++ A VN        P+H A + GHT +V  L    ++ +     G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 142 PLELALQRGAQDLV 155
           PL +A + G  + V
Sbjct: 506 PLHIAAREGHVETV 519



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D      +L +   +PD L++ G T L +   + +  +A  LL +GAS N    +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A+R G +  +++L++ GA +         P+H A + GH  +   L    + + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +   GL+P+ +A Q    D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
           AAR    EV + L +     +A  +  +T L      G T +   LL+  A+PN+  T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
            +P+H AAR G ++T+  L+E  A        G  P+H+A + G   V   L  E D H 
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562

Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
             A   GLTPL +A+     D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV R L +     +A +  G T L +    G   +   LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
            +P+H  A+ G +    VL++HG  V+     G  P+H+A   G+  +V FL   ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +   G +PL  A Q+G  D+V +L  +  +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           AA+GD  +  RLL +     D +     T L V    G   +A  LL +GA PN +  +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
            +P+H A +   +  +++L++ GA ++    +G  P+H+A   GH  +V + L   +  +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + +  TPL +A + G  ++   L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  +L +  V  DA  R G T L V   +G+  +   LL+  A  N +   G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           + G  D + +L+++GA  N     G  P+ +A + G+ +V   L   +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
           AAR+G LD     + +G D+N  +  G   +HLA +EGH   VV  L  E  L     +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 140 LTPLELALQRGAQDLV 155
            T L +A   G  ++V
Sbjct: 79  NTALHIAALAGQDEVV 94



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV + L     + +     G T L V +  G   +   L+  G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
              +H AAR     T  VL+++  + +V   TG  P+H+A    +  V   L    + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
                G+TPL +A +RG   +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 79.3 bits (194), Expect = 1e-15
 Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V+    LL R+  HP+A  + G T L V +  +   I   LL +G SP+    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H AA+   ++  + L+++G   N     G  P+HLA QEGH  +V+  L+ +++ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
           +  +  GLTPL L  Q G   + D+L  H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
           A+  G V+ V  LLH+E++  +   + G TAL +  + G   +  EL+  GA+ N Q   
Sbjct: 52  ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           G +P++ AA+   L+ +K L+E+GA+ NV    G  P+ +A+Q+GH  VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 4   EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
           E V+    L  AA  G  + V  LL ++  + +  N+ G T L  V   G   +A  L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 63  QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
            G   +     G +P+H A+  G +  +K L++H ADVN     G  P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
           V+ L    +  +   + G TPL +A + G   + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  LL +     DA+   G T L V  F G   I   LL++GASPNV +    +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
           R G  +  K L+++ A VN        P+H A + GHT +V  L    ++ +     G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 142 PLELALQRGAQDLV 155
           PL +A + G  + V
Sbjct: 506 PLHIAAREGHVETV 519



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D      +L +   +PD L++ G T L +   + +  +A  LL +GAS N    +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A+R G +  +++L++ GA +         P+H A + GH  +   L    + + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +   GL+P+ +A Q    D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
           AAR    EV + L +     +A  +  +T L      G T +   LL+  A+PN+  T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
            +P+H AAR G ++T+  L+E  A        G  P+H+A + G   V   L  E D H 
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562

Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
             A   GLTPL +A+     D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV R L +     +A +  G T L +    G   +   LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
            +P+H  A+ G +    VL++HG  V+     G  P+H+A   G+  +V FL   ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +   G +PL  A Q+G  D+V +L  +  +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           AA+GD  +  RLL +     D +     T L V    G   +A  LL +GA PN +  +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
            +P+H A +   +  +++L++ GA ++    +G  P+H+A   GH  +V + L   +  +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + +  TPL +A + G  ++   L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  +L +  V  DA  R G T L V   +G+  +   LL+  A  N +   G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           + G  D + +L+++GA  N     G  P+ +A + G+ +V   L   +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
           AAR+G LD     + +G D+N  +  G   +HLA +EGH   VV  L  E  L     +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 140 LTPLELALQRGAQDLV 155
            T L +A   G  ++V
Sbjct: 79  NTALHIAALAGQDEVV 94



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV + L     + +     G T L V +  G   +   L+  G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
              +H AAR     T  VL+++  + +V   TG  P+H+A    +  V   L    + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
                G+TPL +A +RG   +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 79.3 bits (194), Expect = 1e-15
 Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V+    LL R+  HP+A  + G T L V +  +   I   LL +G SP+    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H AA+   ++  + L+++G   N     G  P+HLA QEGH  +V+  L+ +++ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
           +  +  GLTPL L  Q G   + D+L  H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
           A+  G V+ V  LLH+E++  +   + G TAL +  + G   +  EL+  GA+ N Q   
Sbjct: 52  ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           G +P++ AA+   L+ +K L+E+GA+ NV    G  P+ +A+Q+GH  VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 4   EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
           E V+    L  AA  G  + V  LL ++  + +  N+ G T L  V   G   +A  L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 63  QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
            G   +     G +P+H A+  G +  +K L++H ADVN     G  P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
           V+ L    +  +   + G TPL +A + G   + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  LL +     DA+   G T L V  F G   I   LL++GASPNV +    +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
           R G  +  K L+++ A VN        P+H A + GHT +V  L    ++ +     G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 142 PLELALQRGAQDLV 155
           PL +A + G  + V
Sbjct: 506 PLHIAAREGHVETV 519



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D      +L +   +PD L++ G T L +   + +  +A  LL +GAS N    +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A+R G +  +++L++ GA +         P+H A + GH  +   L    + + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +   GL+P+ +A Q    D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
           AAR    EV + L +     +A  +  +T L      G T +   LL+  A+PN+  T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
            +P+H AAR G ++T+  L+E  A        G  P+H+A + G   V   L  E D H 
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562

Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
             A   GLTPL +A+     D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV R L +     +A +  G T L +    G   +   LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
            +P+H  A+ G +    VL++HG  V+     G  P+H+A   G+  +V FL   ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +   G +PL  A Q+G  D+V +L  +  +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           AA+GD  +  RLL +     D +     T L V    G   +A  LL +GA PN +  +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
            +P+H A +   +  +++L++ GA ++    +G  P+H+A   GH  +V + L   +  +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + +  TPL +A + G  ++   L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  +L +  V  DA  R G T L V   +G+  +   LL+  A  N +   G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           + G  D + +L+++GA  N     G  P+ +A + G+ +V   L   +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
           AAR+G LD     + +G D+N  +  G   +HLA +EGH   VV  L  E  L     +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 140 LTPLELALQRGAQDLV 155
            T L +A   G  ++V
Sbjct: 79  NTALHIAALAGQDEVV 94



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV + L     + +     G T L V +  G   +   L+  G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
              +H AAR     T  VL+++  + +V   TG  P+H+A    +  V   L    + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
                G+TPL +A +RG   +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 79.3 bits (194), Expect = 1e-15
 Identities = 51/151 (33%), Positives = 80/151 (52%), Gaps = 3/151 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTS 73
           AA  G V+    LL R+  HP+A  + G T L V +  +   I   LL +G SP+    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
           G +P+H AA+   ++  + L+++G   N     G  P+HLA QEGH  +V+  L+ +++ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGHMV 163
           +  +  GLTPL L  Q G   + D+L  H V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTS 73
           A+  G V+ V  LLH+E++  +   + G TAL +  + G   +  EL+  GA+ N Q   
Sbjct: 52  ASKEGHVKMVVELLHKEIIL-ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
           G +P++ AA+   L+ +K L+E+GA+ NV    G  P+ +A+Q+GH  VV+ L
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163



 Score = 68.6 bits (166), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 4   EEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLK 62
           E V+    L  AA  G  + V  LL ++  + +  N+ G T L  V   G   +A  L+K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 63  QGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV 122
            G   +     G +P+H A+  G +  +K L++H ADVN     G  P+H A Q+GHT +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 123 VSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQ 159
           V+ L    +  +   + G TPL +A + G   + D+L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 46/134 (34%), Positives = 66/134 (49%), Gaps = 2/134 (1%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  LL +     DA+   G T L V  F G   I   LL++GASPNV +    +P+H AA
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLT 141
           R G  +  K L+++ A VN        P+H A + GHT +V  L    ++ +     G T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 142 PLELALQRGAQDLV 155
           PL +A + G  + V
Sbjct: 506 PLHIAAREGHVETV 519



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           AAR D      +L +   +PD L++ G T L +   + +  +A  LL +GAS N    +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            +P+H A+R G +  +++L++ GA +         P+H A + GH  +   L    + + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +   GL+P+ +A Q    D V +L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLL 324



 Score = 65.5 bits (158), Expect = 2e-11
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSG 74
           AAR    EV + L +     +A  +  +T L      G T +   LL+  A+PN+  T+G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
            +P+H AAR G ++T+  L+E  A        G  P+H+A + G   V   L  E D H 
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHP 562

Query: 135 RDA--RGLTPLELALQRGAQDLVDIL 158
             A   GLTPL +A+     D+V +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLL 588



 Score = 62.4 bits (150), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV R L +     +A +  G T L +    G   +   LL + A+ N+ + SG
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLH 133
            +P+H  A+ G +    VL++HG  V+     G  P+H+A   G+  +V FL   ++D++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 134 RRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            +   G +PL  A Q+G  D+V +L  +  +P
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSG 74
           AA+GD  +  RLL +     D +     T L V    G   +A  LL +GA PN +  +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVV-SFLAAESDLH 133
            +P+H A +   +  +++L++ GA ++    +G  P+H+A   GH  +V + L   +  +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
             + +  TPL +A + G  ++   L
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYL 456



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 34/109 (31%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 24  VRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAA 82
           V  +L +  V  DA  R G T L V   +G+  +   LL+  A  N +   G SP+H AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 83  RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
           + G  D + +L+++GA  N     G  P+ +A + G+ +V   L   +D
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARG 139
           AAR+G LD     + +G D+N  +  G   +HLA +EGH   VV  L  E  L     +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 140 LTPLELALQRGAQDLV 155
            T L +A   G  ++V
Sbjct: 79  NTALHIAALAGQDEVV 94



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 6/145 (4%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 74
           AA+ +  EV + L     + +     G T L V +  G   +   L+  G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
              +H AAR     T  VL+++  + +V   TG  P+H+A    +  V   L    + ++
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
                G+TPL +A +RG   +V +L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 72.4 bits (176), Expect = 2e-13
 Identities = 54/150 (36%), Positives = 78/150 (52%), Gaps = 4/150 (2%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQ 70
           L  AAA G ++ V+ LL R     D  N FG TAL +  + G  A+A+EL+  GA+ N  
Sbjct: 210 LHTAAASGQIEVVKYLL-RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268

Query: 71  DTSGTSPVHDAA-RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH-TAVVSFLAA 128
           +  G +P+H AA  T     L++LV +GADVN     G  P+H+A   G  T     +  
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328

Query: 129 ESDLHRRDARGLTPLELALQRGAQDLVDIL 158
            S++   D  G TPL +A + G + L+  L
Sbjct: 329 GSEIDCADKFGNTPLHVAARYGHELLISTL 358



 Score = 63.5 bits (153), Expect = 8e-11
 Identities = 52/169 (30%), Positives = 79/169 (46%), Gaps = 8/169 (4%)

Query: 1   MLLEEVRAGDRLSGAAARGDVQEVRRLLH--RELVHPDALNRFGKTALQV-MMFGSTAIA 57
           ++ E  R    L  AAA G    +  L+         D ++ +G+T L + +M G     
Sbjct: 645 LIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704

Query: 58  LELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQE 117
             LL++G++ +  D  G + +H  A TG  D L  L++H A V   D  G  PIHLA   
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASAC 764

Query: 118 GHTAVV-SFLAAESDLHRRDA----RGLTPLELALQRGAQDLVDILQGH 161
           GHTAV+ + L A       DA     G +P+  A   G +D +++L  H
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score = 58.5 bits (140), Expect = 2e-09
 Identities = 47/145 (32%), Positives = 69/145 (47%), Gaps = 2/145 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFG-STAIALELLKQGASPNVQDTSG 74
           AA    ++V  LL       +A ++  +T L V     +T  A  L    +S NV D SG
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLH 133
            S +H A  +G L+T+ +L+  GA +NV D     P+H A   GH  V+  L A  +DL 
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200

Query: 134 RRDARGLTPLELALQRGAQDLVDIL 158
            +D +G   L  A   G  ++V  L
Sbjct: 201 CKDRKGYGLLHTAAASGQIEVVKYL 225



 Score = 58.2 bits (139), Expect = 3e-09
 Identities = 46/141 (32%), Positives = 70/141 (49%), Gaps = 3/141 (2%)

Query: 20  DVQEVRRLLHRELVHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPV 78
           DV+EVR LL ++  + + L++  +T L    + G   I   LL  GA+ N +DT   +P+
Sbjct: 20  DVEEVRSLLSQK-ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL 78

Query: 79  HDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESDLHRRDA 137
           H AA +     L +L+ H ADVN  D     P+H+A     T     LA   S L+  D 
Sbjct: 79  HRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADR 138

Query: 138 RGLTPLELALQRGAQDLVDIL 158
            G + L  A+  G  + V++L
Sbjct: 139 SGRSALHHAVHSGHLETVNLL 159



 Score = 57.4 bits (137), Expect = 6e-09
 Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 3/110 (2%)

Query: 60  LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADV--NVPDGTGALPIHLAVQE 117
           LL  GA P+++D  G + VH AA  G    L++L+E   +   +V       P+HLA   
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595

Query: 118 GHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL 166
           GH   +  LA    +L  RD +G T L LA +RG+ + V++L  H  + L
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645



 Score = 55.5 bits (132), Expect = 2e-08
 Identities = 44/121 (36%), Positives = 60/121 (49%), Gaps = 3/121 (2%)

Query: 39  NRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           +R G++AL   +  G       LL +GAS NV D     P+H AA  G L+ LK+LV  G
Sbjct: 137 DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 196

Query: 98  ADVNVPDGTGALPIHLAVQEGHTAVVSF-LAAESDLHRRDARGLTPLELALQRGAQDLVD 156
           AD+   D  G   +H A   G   VV + L   +++   +A G T L +A   G QD V 
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG-QDAVA 255

Query: 157 I 157
           I
Sbjct: 256 I 256



 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 2/85 (2%)

Query: 68  NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL- 126
           N +D  G +P+H AA    +  L++L++H A+VN  D TG   +  A + G TA V FL 
Sbjct: 852 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911

Query: 127 -AAESDLHRRDARGLTPLELALQRG 150
              ++DL   D    T L LA  +G
Sbjct: 912 YRGKADLTVLDENKNTALHLACSKG 936



 Score = 47.8 bits (112), Expect = 4e-06
 Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 1/88 (1%)

Query: 60  LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEG- 118
           +L  G   N  D  G + +H AA  G ++ L +L+  GAD+   D  G  P+H A   G 
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468

Query: 119 HTAVVSFLAAESDLHRRDARGLTPLELA 146
           +   V+ + A + ++  D +G +PL  A
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYA 496



 Score = 47.8 bits (112), Expect = 4e-06
 Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 8/102 (7%)

Query: 52  GSTAIALELLKQGASPNVQDT----SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTG 107
           G TA+   LL+   S +  D     SG SP+H A+ TG  D L++L+EH +  +  +G  
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 823

Query: 108 ALPIHLAV---QEGHTAVVSFLAAESDLHRRDARGLTPLELA 146
             P+H AV   Q+  T ++        ++ RDA+G TPL  A
Sbjct: 824 FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAA 865



 Score = 43.9 bits (102), Expect = 6e-05
 Identities = 42/134 (31%), Positives = 53/134 (39%), Gaps = 13/134 (9%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           +  G+T L     G     L LL   GA    +D  G +P+H AA  G       LV  G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479

Query: 98  ADVNVPDGTGALPIHLAV-------QEGHTAVVSFLAAESDLHRRDAR---GLTPLELAL 147
           A VN  D  G  P+H A         E HT   S   AE D   +++R       LE  L
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTP--SSHDAEEDEPLKESRRKEAFFCLEFLL 537

Query: 148 QRGAQDLVDILQGH 161
             GA   +   QG+
Sbjct: 538 DNGADPSLRDRQGY 551



 Score = 43.5 bits (101), Expect = 8e-05
 Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 6/126 (4%)

Query: 42  GKTALQVMMFGSTAIALELLKQG-ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG-AD 99
           G+T L    F      L +L Q  A  N  D +G + +  AA  G    ++ L+  G AD
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKAD 917

Query: 100 VNVPDGTGALPIHLAVQEGHTAVVSFLAAESD----LHRRDARGLTPLELALQRGAQDLV 155
           + V D      +HLA  +GH      + AE+     ++  ++    PL +A + G   +V
Sbjct: 918 LTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVV 977

Query: 156 DILQGH 161
             L  H
Sbjct: 978 QALLSH 983



 Score = 43.1 bits (100), Expect = 1e-04
 Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 7/151 (4%)

Query: 15  AAARGDVQEVRRLLHREL-VHPDALNRFGKTALQVMMFGSTAIALELLKQG-ASPNVQDT 72
           AAA G+ Q +  LL        D  +    + L +  +     AL+ L +   + +V+D 
Sbjct: 557 AAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH 616

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGA-LPIHLAVQEGHTAVVSFLAAESD 131
            G + +  A   G  + ++VL  HGA   + +      P+H A   GHT  +  L    +
Sbjct: 617 KGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676

Query: 132 ----LHRRDARGLTPLELALQRGAQDLVDIL 158
                   DA G TPL LA+  G  D V +L
Sbjct: 677 RADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707



 Score = 36.6 bits (83), Expect = 0.010
 Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 12/122 (9%)

Query: 1   MLLE---EVRAGDR-----LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMF- 51
           MLL+   EV A D      L  AA  G    V  LL+R       L+    TAL +    
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935

Query: 52  GSTAIALELLKQGASPNVQDTSGTS---PVHDAARTGFLDTLKVLVEHGADVNVPDGTGA 108
           G    AL +L +     + + + ++   P+H AAR G    ++ L+ HGA V   D  G 
Sbjct: 936 GHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGH 995

Query: 109 LP 110
            P
Sbjct: 996 TP 997



 Score = 34.7 bits (78), Expect = 0.038
 Identities = 34/137 (24%), Positives = 61/137 (44%), Gaps = 7/137 (5%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL--KQGASPNV 69
           L  AA   +V  +R LL  +    +A +  G+TAL          A+E L  +  A   V
Sbjct: 862 LHAAAFADNVSGLRMLLQHQ-AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 920

Query: 70  QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGA---LPIHLAVQEGHTAVV-SF 125
            D +  + +H A   G      +++    D+ + + T +   +P+H+A + G  +VV + 
Sbjct: 921 LDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980

Query: 126 LAAESDLHRRDARGLTP 142
           L+  + +   D  G TP
Sbjct: 981 LSHGATVLAVDEEGHTP 997



 Score = 30.4 bits (67), Expect = 0.73
 Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 1/86 (1%)

Query: 77  PVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRR 135
           P+  A  +  ++ ++ L+    ++NV D     P+H A   G   ++   L + ++++ +
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 136 DARGLTPLELALQRGAQDLVDILQGH 161
           D   LTPL  A     + ++ +L  H
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAH 96


>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
           [Homo sapiens]
          Length = 423

 Score = 72.0 bits (175), Expect = 2e-13
 Identities = 44/144 (30%), Positives = 76/144 (52%), Gaps = 1/144 (0%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSG 74
           AA+   +++ +L+     HPD  + +G T L +    G T I   LL++GA+ + Q +  
Sbjct: 26  AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHR 134
           +S + +AA  G  D + +L+E+GAD N+P  +G LPIH+A   GH   +  L   +DL  
Sbjct: 86  SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAA 145

Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
               G++P+  A        +++L
Sbjct: 146 IKQSGISPVHCAAAGAHPQCLELL 169



 Score = 43.9 bits (102), Expect = 6e-05
 Identities = 29/104 (27%), Positives = 53/104 (50%), Gaps = 1/104 (0%)

Query: 56  IALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV 115
           +A  L+  GA  N++  +  + +H+AA+ G  D +K+++  GA  +     G  P+ LA 
Sbjct: 1   MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60

Query: 116 QEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDIL 158
           Q GHT ++  L  + ++ H + +   + L  A   G  D V +L
Sbjct: 61  QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALL 104



 Score = 35.8 bits (81), Expect = 0.017
 Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 11/98 (11%)

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVP---------DGTGALPIHLAVQEGHTAVV 123
           SG SPVH AA       L++L++ G DVN           D      ++ AV     + V
Sbjct: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208

Query: 124 SFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
             L +   L  +D   +  L++AL+ G  +L+ +L  H
Sbjct: 209 KLLLSAGALPNQDP--VNCLQIALRMGNYELISLLLRH 244



 Score = 26.9 bits (58), Expect = 8.0
 Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 4/60 (6%)

Query: 43  KTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVN 101
           K+AL   +  S   +++LL   GA PN QD      +  A R G  + + +L+ HGA+VN
Sbjct: 193 KSALYFAVSNSDLSSVKLLLSAGALPN-QDPVNCLQI--ALRMGNYELISLLLRHGANVN 249


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 71.6 bits (174), Expect = 3e-13
 Identities = 43/108 (39%), Positives = 58/108 (53%), Gaps = 1/108 (0%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           GS    + LLK+GA+PN QD SG +P+H AAR G    +  L+E+ ADVN+ +  G   I
Sbjct: 76  GSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAI 135

Query: 112 HLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDIL 158
           H     G T ++  L    SD+   DA G T L +A Q G +  V  L
Sbjct: 136 HWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCL 183



 Score = 64.7 bits (156), Expect = 3e-11
 Identities = 35/121 (28%), Positives = 64/121 (52%), Gaps = 1/121 (0%)

Query: 39  NRFGKTALQ-VMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N  G TA+  + + G T +  +L++  +  +V+D  G + +H A + G   T++ L++ G
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSG 187

Query: 98  ADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDI 157
           AD+N P+ +GA P++ A   G       L      +  D  G+TPL+L +Q G  +  ++
Sbjct: 188 ADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEV 247

Query: 158 L 158
           L
Sbjct: 248 L 248



 Score = 43.1 bits (100), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 1/88 (1%)

Query: 76  SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHR 134
           S +H AA  G ++ L +L++ GA+ N  D +G  P+HLA + G    +S  L   +D++ 
Sbjct: 67  SLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126

Query: 135 RDARGLTPLELALQRGAQDLVDILQGHM 162
            +  GLT +      G  +L+  L  H+
Sbjct: 127 CNNEGLTAIHWLAVNGRTELLHDLVQHV 154


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 70.9 bits (172), Expect = 5e-13
 Identities = 57/177 (32%), Positives = 80/177 (45%), Gaps = 24/177 (13%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST---------AIALELLK 62
           L  AAA+G   E+ +LL +    P   NR G T L ++  G T         A  L+  K
Sbjct: 754 LHEAAAKGKY-EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAK 812

Query: 63  QGASPNVQ-----------DTSG--TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 109
           +G    VQ           DT G  ++P+H AA    L+  + L+EHGADVN  D  G +
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872

Query: 110 PIHLAVQEGHTAVVSFLAAESD-LHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
           P+H A   GH  + + L   +  ++  D    TPL  A Q+G   L  +L  H   P
Sbjct: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929



 Score = 66.6 bits (161), Expect = 9e-12
 Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 3/152 (1%)

Query: 11  RLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNV 69
           RL  A+  GD++ V++L   + V+   L     T L     +   ++   LL  GA  + 
Sbjct: 653 RLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712

Query: 70  QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE 129
           +D  G  P+H+A   G  +  ++LV HGA VNV D     P+H A  +G   +   L   
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772

Query: 130 -SDLHRRDARGLTPLELALQRGAQDLVDILQG 160
            +D  +++  G TPL+L ++ G  D+ D+L+G
Sbjct: 773 GADPTKKNRDGNTPLDL-VKEGDTDIQDLLRG 803



 Score = 66.2 bits (160), Expect = 1e-11
 Identities = 45/147 (30%), Positives = 75/147 (51%), Gaps = 3/147 (2%)

Query: 3   LEEVRAGDR-LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALEL 60
           ++++  GD  L  AA +G +  V++L   E ++         T L +   + +  +A  L
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856

Query: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
           L+ GA  N QD  G  P+H+AA  G +D   +L+++   VN  D     P+H A Q+G T
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916

Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELA 146
            + + L A  +D   ++  G TPL+LA
Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score = 55.1 bits (131), Expect = 3e-08
 Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)

Query: 15  AAARGDVQEVRRLLHRELVHP-DALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTS 73
           A   GDV  V+RL+    V+  D   R          FG   +   LL+ GA+ + +D  
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAV-VSFLAAESDL 132
           G  P+H+A   G  + + +L+  GAD N  D     P+H A  +G   V +  L   +D 
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308

Query: 133 HRRDARGLTPLELA 146
           + R+  G + L+LA
Sbjct: 309 NIRNTDGKSALDLA 322



 Score = 55.1 bits (131), Expect = 3e-08
 Identities = 44/166 (26%), Positives = 62/166 (37%), Gaps = 55/166 (33%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV--PDGTGA 108
           FG   +   LL QGA PN +D    +P+H+AA  G +D   VL++HGAD N+   DG  A
Sbjct: 259 FGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSA 318

Query: 109 L----------------------------------------------------PIHLAVQ 116
           L                                                    P+HLA  
Sbjct: 319 LDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAG 378

Query: 117 EGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
                +V  L    +D+H +D  GL PL  A   G  ++ ++L  H
Sbjct: 379 YNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424



 Score = 50.1 bits (118), Expect = 9e-07
 Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 34/175 (19%)

Query: 17  ARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNV------ 69
           A  DV EV   LH+     +AL+  G+TAL +  + G       LL  G+ P++      
Sbjct: 569 AHNDVMEV---LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF 625

Query: 70  -----------QDTSGTSPVH---------DAARTGFLDTLKVLVEHGADVNVPD--GTG 107
                      Q  S ++P+          +A++ G L+T+K L     +VN  D  G  
Sbjct: 626 TAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRH 684

Query: 108 ALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
           + P+H A      +VV +L    +D+H +D  GL PL  A   G  ++ ++L  H
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739



 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 1/118 (0%)

Query: 10  DRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPN 68
           D L  AA  G+ +++  LL    V+  A +    T L +   +    I   LL+ GA  +
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396

Query: 69  VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +D  G  P+H+A   G  +  ++L++HGA VN  D     P+H A  +    V S L
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454



 Score = 47.4 bits (111), Expect = 6e-06
 Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 3/114 (2%)

Query: 9   GDRLSGAAARGDVQEVRRLLHRELVH---PDALNRFGKTALQVMMFGSTAIALELLKQGA 65
           G  L  AA   D+ +V++ L  E+++   P +       A+  +      +   LL++GA
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549

Query: 66  SPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 119
           + N ++    +P+H AA     D ++VL +HGA +N  D  G   +H A   GH
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603



 Score = 43.9 bits (102), Expect = 6e-05
 Identities = 34/116 (29%), Positives = 56/116 (48%), Gaps = 5/116 (4%)

Query: 22  QEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHD 80
           ++V  LL R+  + +  N+   T L V    +    +E+L K GA  N  DT G + +H 
Sbjct: 538 KQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597

Query: 81  AARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRD 136
           AA  G L T ++L+ +G+D ++    G      A Q G+ AV   L+  + +   D
Sbjct: 598 AALAGHLQTCRLLLSYGSDPSIISLQG----FTAAQMGNEAVQQILSESTPIRTSD 649



 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 22/73 (30%), Positives = 36/73 (49%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
           +G   IA  L+K     N  D    +P+H+AA+ G      +L+ HGAD  + +  G  P
Sbjct: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939

Query: 111 IHLAVQEGHTAVV 123
           + LA  +   A++
Sbjct: 940 LDLATADDIRALL 952



 Score = 38.9 bits (89), Expect = 0.002
 Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 4/82 (4%)

Query: 80  DAARTGFLDTLKVLVEHGADVNVPDGTG--ALPIHLAVQEGHTAVVS-FLAAESDLHRRD 136
           +A R G +  +K LV+  A+VN  D  G  + P+H A   G   VV   L   +++H RD
Sbjct: 188 EACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246

Query: 137 ARGLTPLELALQRGAQDLVDIL 158
             GL PL  A   G  ++V +L
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLL 268



 Score = 36.6 bits (83), Expect = 0.010
 Identities = 19/64 (29%), Positives = 32/64 (50%)

Query: 51  FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALP 110
           +G   +   LLK GA  N  D    +P+H+AA    ++   +L+ HGAD  + +  G   
Sbjct: 412 YGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 471

Query: 111 IHLA 114
           + +A
Sbjct: 472 VDMA 475


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 70.5 bits (171), Expect = 6e-13
 Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 3/158 (1%)

Query: 3   LEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALE-LL 61
           L E      L  AA  G V  V+ LL  +    DA  R  +T L + +      A++ LL
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547

Query: 62  KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTA 121
           K GA P+  D SG  P+H AA  G     K+L+ +GA + +P   G  P+HLA  +GH  
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607

Query: 122 VVSFLA-AESDLHRRDARGLTPLELALQRGAQDLVDIL 158
           ++  LA + +++    A   TPL LA + G + +V  L
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645



 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 5/149 (3%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTS 73
           AA +G + E+  LL     +  AL     T L +    G  A+   LL+ GA PN  + S
Sbjct: 600 AAYKGHL-EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658

Query: 74  GTSPVHDAA-RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-AESD 131
           G +P+H A  R+ FL  + +L EH A+V+  +  G  P HLA  +G+TA++  L  A + 
Sbjct: 659 GWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717

Query: 132 LHRRDARGLTPLELALQRGAQDLVDILQG 160
           L  +D    TPL+LAL+   Q ++  L+G
Sbjct: 718 LDVQDGVSCTPLQLALRSRKQGIMSFLEG 746



 Score = 68.9 bits (167), Expect = 2e-12
 Identities = 50/144 (34%), Positives = 72/144 (50%), Gaps = 3/144 (2%)

Query: 17  ARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDTSGT 75
           A+G V++VR LL  E V  D     G T L +        +   LL  GA  N  D  G 
Sbjct: 371 AQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429

Query: 76  SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHR 134
           +P+H AA+ G   T ++L++HGA V+  +  G  P+HLA Q     V   L + ++D + 
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 135 RDARGLTPLELALQRGAQDLVDIL 158
            +A G TPL +A   G   LV +L
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLL 513



 Score = 64.7 bits (156), Expect = 3e-11
 Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 5/102 (4%)

Query: 52  GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 111
           G    A  LL  GA  + Q+  G +P+H AA+  F +  ++LV   AD N+ +  G  P+
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPL 498

Query: 112 HLAVQEGHTAVVSFL---AAESDLHRRDARGLTPLELALQRG 150
           H+A   GH ++V  L    AE D  +R+ R  TPL LA++RG
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLR--TPLHLAVERG 538



 Score = 55.5 bits (132), Expect = 2e-08
 Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 5/139 (3%)

Query: 15  AAARGDVQEVRRLL-HRELVHPDALNRFGKTALQVMMFGSTA-IALELLKQGASPNVQDT 72
           AA  GD    R LL H   V  DA  R G T L +    +   +A  L+ + A PN+ + 
Sbjct: 435 AAQNGDDGTARLLLDHGACV--DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492

Query: 73  SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDL 132
            G +P+H AA  G +  +K+L   GA+++        P+HLAV+ G    +  L     +
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV 552

Query: 133 -HRRDARGLTPLELALQRG 150
               D  G  PL  A  RG
Sbjct: 553 PDALDQSGYGPLHTAAARG 571



 Score = 42.7 bits (99), Expect = 1e-04
 Identities = 24/87 (27%), Positives = 42/87 (48%), Gaps = 1/87 (1%)

Query: 76  SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHR 134
           +P+H     G ++ +++L+ H  DV+    +G  P+ +A Q+    + + L A  +D +R
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 135 RDARGLTPLELALQRGAQDLVDILQGH 161
            D  G  PL  A Q G      +L  H
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDH 450


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 70.1 bits (170), Expect = 8e-13
 Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 24/177 (13%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST---------AIALELLK 62
           L  AAA+G   E+ +LL +    P   NR G T L ++  G T         A  L+  K
Sbjct: 596 LHEAAAKGKY-EICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAK 654

Query: 63  QG--------ASP---NVQDTSG--TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 109
           +G        +SP   N +DT G  ++P+H AA    L+  + L++HGADVN  D  G +
Sbjct: 655 KGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLI 714

Query: 110 PIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
           P+H A   GH  V + L    + ++  D    TPL  A Q+G   L  +L  H   P
Sbjct: 715 PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771



 Score = 66.2 bits (160), Expect = 1e-11
 Identities = 49/163 (30%), Positives = 80/163 (49%), Gaps = 6/163 (3%)

Query: 3   LEEVRAGDR-LSGAAARGDVQEVRRLLHRELVH-PDALNRFGKTALQVMMFGSTAIALEL 60
           ++++  GD  L  AA +G +  V++L   + V+  D   R          + +  +A  L
Sbjct: 639 IQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYL 698

Query: 61  LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT 120
           L+ GA  N QD  G  P+H+AA  G +D   +L+++ A VN  D     P+H A Q+G T
Sbjct: 699 LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758

Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHM 162
            + + L A  +D   ++  G TPL+L     A D+  +L   M
Sbjct: 759 QLCALLLAHGADPTLKNQEGQTPLDLV---SADDVSALLTAAM 798



 Score = 65.9 bits (159), Expect = 2e-11
 Identities = 47/155 (30%), Positives = 79/155 (50%), Gaps = 3/155 (1%)

Query: 8   AGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGAS 66
           A  +L  AA  GDV+ V++L   + V+   +     T L     +   ++   LL+ GA 
Sbjct: 492 ADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGAD 551

Query: 67  PNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            + +D  G  P+H+A   G  +  ++LV+HGA VNV D     P+H A  +G   +   L
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 127 AAE-SDLHRRDARGLTPLELALQRGAQDLVDILQG 160
               +D  +++  G TPL+L ++ G  D+ D+L+G
Sbjct: 612 LQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG 645



 Score = 61.2 bits (147), Expect = 4e-10
 Identities = 46/143 (32%), Positives = 64/143 (44%), Gaps = 6/143 (4%)

Query: 8   AGDRLSGAAARGDVQEVRRLLHRELVHP-DALNRFGKTALQVMMFGSTAIALELLKQGAS 66
           A   L  A   GDV+ V+RL+  E V+  D   R          FG   +   LL+ GA+
Sbjct: 24  AARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN 83

Query: 67  PNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
              +D  G  P+H+A   G  + + +L+ HGAD N  D     P+H A  +G   V   L
Sbjct: 84  VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143

Query: 127 ---AAESDLHRRDARGLTPLELA 146
               AE  +   D R  T L+LA
Sbjct: 144 LQHGAEPTIRNTDGR--TALDLA 164



 Score = 48.9 bits (115), Expect = 2e-06
 Identities = 44/155 (28%), Positives = 67/155 (43%), Gaps = 8/155 (5%)

Query: 9   GDRLSGAAARGDVQEVRRLLHRELV---HPDALNRFGKTALQVMMFGSTAIALELLKQGA 65
           G  L  AA   DV  +++ L  E+V   HP         A          I   LL++GA
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391

Query: 66  SPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSF 125
           + N +     +P+H A+     D ++V+V+H A VN  D  G   +H A   GH      
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451

Query: 126 LAAES-DLHRRDARGLTPLELALQRGAQDLVDILQ 159
           L +   D +    +G T    ALQ G +++  +LQ
Sbjct: 452 LLSYGCDPNIISLQGFT----ALQMGNENVQQLLQ 482



 Score = 48.1 bits (113), Expect = 3e-06
 Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 23/162 (14%)

Query: 23  EVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSPVH-- 79
           EV  LL R    P+A + +  T L +  + G   + + LL+ GA P +++T G + +   
Sbjct: 105 EVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164

Query: 80  ------------------DAARTGFLDTLKVLVEH-GADVNVPDGTGALPIHLAVQEGHT 120
                             ++AR+G  + +  L+     + +  DG  + P+HLA      
Sbjct: 165 DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 224

Query: 121 AVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
            +V  L    +D+H +D   L PL  A   G  ++ ++L  H
Sbjct: 225 KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266



 Score = 47.0 bits (110), Expect = 7e-06
 Identities = 40/151 (26%), Positives = 65/151 (43%), Gaps = 7/151 (4%)

Query: 10  DRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPN 68
           D L  +A  G+ +++  LL    V+  A +    T L +   +    I   LL+ GA  +
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238

Query: 69  VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA 128
            +D     P+H+A   G  +  ++LV+HGA VN  D     P+H A  +    V S L +
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 298

Query: 129 ES------DLHRRDARGLTPLELALQRGAQD 153
                   + H + A  L P     +R A +
Sbjct: 299 YGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329



 Score = 46.6 bits (109), Expect = 1e-05
 Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 11/153 (7%)

Query: 12  LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQD 71
           L  AA  G +Q  R LL      P+ ++  G TALQ+   G+  +  +LL++G S  + +
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGC-DPNIISLQGFTALQM---GNENVQ-QLLQEGIS--LGN 489

Query: 72  TSGTSPVHDAARTGFLDTLKVLVEHGADVNVPD--GTGALPIHLAVQEGHTAVVSFLAAE 129
           +     + +AA+ G ++T+K L    + VN  D  G  + P+H A      +VV +L   
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548

Query: 130 -SDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
            +D+H +D  GL PL  A   G  ++ ++L  H
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581


>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
          Length = 360

 Score = 69.7 bits (169), Expect = 1e-12
 Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 3/149 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTS 73
           AA  G ++ + + L  +    D  ++F +TAL +  + G   I  +LL  GA+ + QD  
Sbjct: 155 AAVEGKMKVIEKFL-ADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDL 132
             + +H A R G L+ +K+L  HGAD NV D   + P+H+AV+ G   +V  FL+   ++
Sbjct: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273

Query: 133 HRRDARGLTPLELALQRGAQDLVDILQGH 161
           + RD  G T L  A++     ++ +L  H
Sbjct: 274 NARDREGDTALHDAVRLNRYKIIKLLLLH 302



 Score = 51.6 bits (122), Expect = 3e-07
 Identities = 32/115 (27%), Positives = 59/115 (51%), Gaps = 1/115 (0%)

Query: 43  KTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV 102
           +T L+  + G   +  + L  G S +  D    + +H A+  G ++ L+ L+++GA V+ 
Sbjct: 150 ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF 209

Query: 103 PDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLVD 156
            D      +H A + GH  VV  L +  +D + RD    TPL +A++ G  ++V+
Sbjct: 210 QDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVE 264



 Score = 43.1 bits (100), Expect = 1e-04
 Identities = 30/99 (30%), Positives = 43/99 (43%), Gaps = 1/99 (1%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           A RG   EV +LL       +  ++   T L V +  G   I    L  G   N +D  G
Sbjct: 221 ACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREG 280

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHL 113
            + +HDA R      +K+L+ HGAD+   +  G  P  L
Sbjct: 281 DTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 42/125 (33%), Positives = 67/125 (53%), Gaps = 5/125 (4%)

Query: 35  PDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94
           PD  +     AL     G+T +   LL+  A+ +++D  G  P+H AA  G  + +K+++
Sbjct: 47  PDGFSALHHAALN----GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102

Query: 95  EHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAA-ESDLHRRDARGLTPLELALQRGAQD 153
           + G+ VN+P   G +P+HLA Q GH  V   L   +S+    D  G TPL+LA + G   
Sbjct: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162

Query: 154 LVDIL 158
           +V +L
Sbjct: 163 VVQLL 167



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 1/99 (1%)

Query: 68  NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSF-L 126
           N QD  G S +H AA  G  + + +L+E  A V++ D  G  P+H A  +G    +   L
Sbjct: 43  NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102

Query: 127 AAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAP 165
            A S ++     G  PL LA Q G  D+ ++L  H   P
Sbjct: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNP 141



 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 9/108 (8%)

Query: 60  LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 119
           +LK G++ N+    G  P+H AA+ G  D  ++L++H ++  + D +G  P+ LA + G 
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160

Query: 120 TAVVSFLAAESDL---------HRRDARGLTPLELALQRGAQDLVDIL 158
             VV  L + +              D  G +PL LA + G  D++ +L
Sbjct: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208



 Score = 48.9 bits (115), Expect = 2e-06
 Identities = 40/143 (27%), Positives = 66/143 (46%), Gaps = 11/143 (7%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASP------- 67
           AA+    +V  +L +   +P  ++  GKT L +   FG   +   LL             
Sbjct: 122 AAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRP 181

Query: 68  -NVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL 126
            +  D +GTSP+H AA+ G +D +++L++ G D+N    +G   +H A   G T VV  L
Sbjct: 182 GDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGT-ALHEAALCGKTEVVRLL 240

Query: 127 AAES-DLHRRDARGLTPLELALQ 148
                + H R+    T L++  Q
Sbjct: 241 LDSGINAHVRNTYSQTALDIVHQ 263



 Score = 38.5 bits (88), Expect = 0.003
 Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 14/110 (12%)

Query: 60  LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG----------ADVNVPDGTGAL 109
           LL+  ++P + D SG +P+  A   G +  +++L+              D   P+GT   
Sbjct: 134 LLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTS-- 191

Query: 110 PIHLAVQEGHTAVVS-FLAAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
           P+HLA + GH  ++   L A  D++R+   G T L  A   G  ++V +L
Sbjct: 192 PLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240



 Score = 31.2 bits (69), Expect = 0.43
 Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 99  DVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRDARGLTPLELALQRGAQD 153
           +VN  D  G   +H A   G+T ++S  L A++ +  +D +G+ PL  A  +G ++
Sbjct: 41  NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 63  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 121

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 122 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 181

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 182 NSRNKSGRTALMLACEIGSSNAVEAL 207



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 20  NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 79

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 80  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 139

Query: 157 ILQGH 161
           IL  H
Sbjct: 140 ILCEH 144



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 185 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 244

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 245 SQDADLKTP 253


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 52  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 110

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 111 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 170

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 171 NSRNKSGRTALMLACEIGSSNAVEAL 196



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 9   NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 68

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 69  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 128

Query: 157 ILQGH 161
           IL  H
Sbjct: 129 ILCEH 133



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 174 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 233

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 234 SQDADLKTP 242


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 60  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 17  NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 77  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136

Query: 157 ILQGH 161
           IL  H
Sbjct: 137 ILCEH 141



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 242 SQDADLKTP 250


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 60  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 17  NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 77  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136

Query: 157 ILQGH 161
           IL  H
Sbjct: 137 ILCEH 141



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 242 SQDADLKTP 250


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 60  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 17  NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 77  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136

Query: 157 ILQGH 161
           IL  H
Sbjct: 137 ILCEH 141



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 242 SQDADLKTP 250


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 49/146 (33%), Positives = 77/146 (52%), Gaps = 3/146 (2%)

Query: 15  AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQ-DTS 73
           AAA+G V E  R++    V   A +  G +AL +    S    +  L Q   P    D+S
Sbjct: 60  AAAKGHV-ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 118

Query: 74  GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE-SDL 132
           G + +H AA  G L  +++L EH + +N+ D  G +P+ LAVQ GH+ +  FL    +D+
Sbjct: 119 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 178

Query: 133 HRRDARGLTPLELALQRGAQDLVDIL 158
           + R+  G T L LA + G+ + V+ L
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEAL 204



 Score = 60.5 bits (145), Expect = 7e-10
 Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 39  NRFGKTALQVMMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHG 97
           N+     LQ +  G       LL K+GAS    D+ G +  H AA  G ++ L+V++ HG
Sbjct: 17  NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76

Query: 98  ADVNVPDGTGALPIHLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
            DV   D TG   +HLA +   H  +   L ++      D+ G T L  A  +G    V 
Sbjct: 77  VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136

Query: 157 ILQGH 161
           IL  H
Sbjct: 137 ILCEH 141



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 20/69 (28%), Positives = 33/69 (47%), Gaps = 4/69 (5%)

Query: 39  NRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHD---AARTGFLDTLKVLV 94
           N+ G+TAL +    GS+     L+K+GA  N+ D+ G + +H    +   G    L   +
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241

Query: 95  EHGADVNVP 103
              AD+  P
Sbjct: 242 SQDADLKTP 250


>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
          Length = 319

 Score = 67.8 bits (164), Expect = 4e-12
 Identities = 41/127 (32%), Positives = 71/127 (55%), Gaps = 2/127 (1%)

Query: 34  HPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKV 92
           +PD  + + +TAL +  + G  AI  +L++ GA    +D   ++ +H A+R G LD LK+
Sbjct: 145 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL 204

Query: 93  LVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGA 151
           L+  GA ++  D   +  +H+AV+ GH      L A E+DL+ +D  G TPL  A++   
Sbjct: 205 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR 264

Query: 152 QDLVDIL 158
             ++ +L
Sbjct: 265 YKMIRLL 271



 Score = 50.4 bits (119), Expect = 7e-07
 Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 3/118 (2%)

Query: 16  AARGDVQEVRRLLHRELVHPDALNRFGKTALQVMM-FGSTAIALELLKQGASPNVQDTSG 74
           A+RG   +V +LL  +     A ++   TAL V +  G    A  L+   A  N +D  G
Sbjct: 193 ASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREG 252

Query: 75  TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV--QEGHTAVVSFLAAES 130
            +P+HDA R      +++L+ +GAD+N+ +  G  P+ L +  Q G  A+   L   S
Sbjct: 253 DTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENS 310


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,793,519
Number of Sequences: 37866
Number of extensions: 236364
Number of successful extensions: 2503
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 572
Number of HSP's gapped (non-prelim): 1253
length of query: 166
length of database: 18,247,518
effective HSP length: 95
effective length of query: 71
effective length of database: 14,650,248
effective search space: 1040167608
effective search space used: 1040167608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 58 (26.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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