Search of human proteins with 17505200

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17505200 transient receptor potential cation channel,
subfamily V, member 5 [Homo sapiens]
         (729 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17505200 transient receptor potential cation channel, subfami...  1464   0.0  
gi|21314682 transient receptor potential cation channel, subfami...  1071   0.0  
gi|22547184 transient receptor potential cation channel, subfami...   266   4e-71
gi|74315354 transient receptor potential cation channel, subfami...   240   3e-63
gi|74315352 transient receptor potential cation channel, subfami...   240   3e-63
gi|74315350 transient receptor potential cation channel, subfami...   240   3e-63
gi|74315348 transient receptor potential cation channel, subfami...   240   3e-63
gi|21735483 transient receptor potential cation channel, subfami...   236   6e-62
gi|22547180 transient receptor potential cation channel, subfami...   206   5e-53
gi|20127551 transient receptor potential cation channel, subfami...   204   3e-52
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        65   2e-10
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         65   2e-10
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         65   2e-10
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         65   2e-10
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         65   2e-10
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        64   5e-10
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         64   5e-10
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         64   5e-10
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    60   9e-09
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...    59   2e-08
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    59   2e-08
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]              58   4e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         57   5e-08
gi|50511945 cajalin 2 isoform a [Homo sapiens]                         56   1e-07
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     54   4e-07
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    54   5e-07
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   54   5e-07
gi|134244285 Notch homolog 3 [Homo sapiens]                            54   7e-07
gi|148833508 notch1 preproprotein [Homo sapiens]                       53   9e-07
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           53   9e-07

>gi|17505200 transient receptor potential cation channel, subfamily
           V, member 5 [Homo sapiens]
          Length = 729

 Score = 1464 bits (3790), Expect = 0.0
 Identities = 729/729 (100%), Positives = 729/729 (100%)

Query: 1   MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60
           MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV
Sbjct: 1   MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60

Query: 61  LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120
           LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA
Sbjct: 61  LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120

Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180
           LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR
Sbjct: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180

Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240
           LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG
Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240

Query: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300
           LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD
Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300

Query: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360
           KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT
Sbjct: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360

Query: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420
           HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI
Sbjct: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420

Query: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480
           LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI
Sbjct: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480

Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540
           MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV
Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540

Query: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600
           IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
Sbjct: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600

Query: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660
           TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ
Sbjct: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660

Query: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE 720
           EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE
Sbjct: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE 720

Query: 721 GDGEEVYHF 729
           GDGEEVYHF
Sbjct: 721 GDGEEVYHF 729


>gi|21314682 transient receptor potential cation channel, subfamily
           V, member 6 [Homo sapiens]
          Length = 725

 Score = 1072 bits (2771), Expect = 0.0
 Identities = 547/729 (75%), Positives = 607/729 (83%), Gaps = 15/729 (2%)

Query: 1   MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60
           MG  LPK +G    L      +  R + W Q  D+ ++LQQKRI ESPLL A+K+ND+  
Sbjct: 1   MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQA 60

Query: 61  LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120
           L +LL    C V QRGA+GETALHIAALYDNLEAA+VLMEAAPELVFEP T E + GQTA
Sbjct: 61  LNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120

Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180
           LHIAVVNQN+NLVRALL RRASVSARATGTAFRRSP NLIYFGEHPLSFAACVNSEEIVR
Sbjct: 121 LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVR 180

Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240
           LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD HGDHLQPLDLVPNHQG
Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQG 240

Query: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300
           LTPFKLAGVEGNTVMFQHLMQKR+H QWTYGPLTS LYDLTEIDS G+E S LEL++++ 
Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTK 300

Query: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360
           KREARQIL+QTPVKELVS KW +YGRPYFC+L A+YLLY+ICFT CC+YRPLK R  NRT
Sbjct: 301 KREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT 360

Query: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420
             RD T+LQQKLLQEAY T +D IRLVGELV+++GA+IILL+E+PDIFR+G +R+FG+TI
Sbjct: 361 SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI 420

Query: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480
           LGGPFHV+IITYA +VLVTMVMRL + +GEVVPMSFALVLGWC+VMYF RGFQMLGPFTI
Sbjct: 421 LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTI 480

Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540
           MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDP  LG FYDYPMALF+TFELFLT+
Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTI 540

Query: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600
           ID PANY+VDLPFM+SI   AFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQ+VAT
Sbjct: 541 IDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT 600

Query: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660
           TVMLERKLPRCLWPRSGICG E+GLGDRWFLRVE+  D N  R+ RY + F     ED  
Sbjct: 601 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLD 660

Query: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTL-----GHLNLG 715
           +   EK     E G      L+LP  S+SR+ S+SS++  WE LRQ TL     G +N G
Sbjct: 661 KDSVEK----LELGCPFSPHLSLPMPSVSRSTSRSSAN--WERLRQGTLRRDLRGIINRG 714

Query: 716 LNLSEGDGE 724
           L     DGE
Sbjct: 715 LE----DGE 719


>gi|22547184 transient receptor potential cation channel, subfamily
           V, member 4 isoform a [Homo sapiens]
          Length = 871

 Score =  266 bits (681), Expect = 4e-71
 Identities = 192/581 (33%), Positives = 286/581 (49%), Gaps = 68/581 (11%)

Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR-RSPRNLIYF 162
           E +  P     + GQTALHIA+  +  + V  L+ + A V A+A G  F+ +      YF
Sbjct: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284

Query: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214
           GE PLS AAC N   IV  L E+    AD+R QDS GNTVLH L+      + N  F  +
Sbjct: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344

Query: 215 MYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR------RHIQ- 267
           MY+LLL           L+ V N+ GL+P  +A   G   +FQH++++       RH+  
Sbjct: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSR 404

Query: 268 ----WTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREAR-QILEQTPVKELVSFKWN 322
               W YGP+ S LYDL+ +D+ GEE S LE++V + K E R ++L   P+ EL+  KW 
Sbjct: 405 KFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWR 464

Query: 323 KYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETRED 382
           K+G   F I    YL  M+ FT    Y+PL+   G   +               Y T  D
Sbjct: 465 KFGAVSFYINVVSYLCAMVIFTLTAYYQPLE---GTPPYP--------------YRTTVD 507

Query: 383 IIRLVGELVSIVGAVIILLLEIPDIFRV---GASRYFGKTILGGPFHVIIITYASLVLVT 439
            +RL GE++++   V+     I D+F     G +  F    + G F ++   Y+ LV+V+
Sbjct: 508 YLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVS 563

Query: 440 MVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAV 499
             + L      +  M FALVLGW + +YFTRG ++ G ++IMIQK++F DL RF  +  +
Sbjct: 564 AALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLL 623

Query: 500 VILGFASAFYIIFQ--------TEDPT--------SLGQFYDYPMALFTTFELFLTVIDA 543
            ++G+ASA   +           ED T        S      +   L   F+L + + D 
Sbjct: 624 FMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDL 683

Query: 544 PANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVM 603
                   P +F I+   + I+  +L+LN+ IA+MG+T  +V++E   +W+ Q   T + 
Sbjct: 684 EMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 743

Query: 604 LERKLPRCLWP--RSG----ICGCEFGLGD-RWFLRVENHN 637
           +ER  P  L    RSG    +     G  D RW  RV+  N
Sbjct: 744 IERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVN 784


>gi|74315354 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  240 bits (613), Expect = 3e-63
 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%)

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158
           ++  ELV    T   + GQTALHIA+  +N+ LV  L+   A V A A G  F+++  R 
Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304

Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364

Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317
              R+  +W YGP+ S LYDL+ ID+  E+ S LE++   SS+      +L   P+  L+
Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423

Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377
             KW+++ +  F     +Y LYMI FT    YRP+                   L     
Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466

Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436
           E   D  R+ GE++S++G V      I    +   S    KT+    +  ++    SL +
Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523

Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496
           L T+V+  ++    V  M F+L LGW +++Y+TRGFQ +G + +MI+KMI  DL RF ++
Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583

Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541
             V + GF++A   + +                  P        Y     T  ELF   I
Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643

Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598
              D     + D   +F I+  A+ I+  +L+LN+ IA+MG+T  ++AQE   +W+ Q  
Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703

Query: 599 ATTVMLERKLPRCL 612
            T +  E+   +C+
Sbjct: 704 ITILDTEKSFLKCM 717


>gi|74315352 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  240 bits (613), Expect = 3e-63
 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%)

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158
           ++  ELV    T   + GQTALHIA+  +N+ LV  L+   A V A A G  F+++  R 
Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304

Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364

Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317
              R+  +W YGP+ S LYDL+ ID+  E+ S LE++   SS+      +L   P+  L+
Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423

Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377
             KW+++ +  F     +Y LYMI FT    YRP+                   L     
Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466

Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436
           E   D  R+ GE++S++G V      I    +   S    KT+    +  ++    SL +
Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523

Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496
           L T+V+  ++    V  M F+L LGW +++Y+TRGFQ +G + +MI+KMI  DL RF ++
Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583

Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541
             V + GF++A   + +                  P        Y     T  ELF   I
Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643

Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598
              D     + D   +F I+  A+ I+  +L+LN+ IA+MG+T  ++AQE   +W+ Q  
Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703

Query: 599 ATTVMLERKLPRCL 612
            T +  E+   +C+
Sbjct: 704 ITILDTEKSFLKCM 717


>gi|74315350 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  240 bits (613), Expect = 3e-63
 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%)

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158
           ++  ELV    T   + GQTALHIA+  +N+ LV  L+   A V A A G  F+++  R 
Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304

Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364

Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317
              R+  +W YGP+ S LYDL+ ID+  E+ S LE++   SS+      +L   P+  L+
Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423

Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377
             KW+++ +  F     +Y LYMI FT    YRP+                   L     
Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466

Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436
           E   D  R+ GE++S++G V      I    +   S    KT+    +  ++    SL +
Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523

Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496
           L T+V+  ++    V  M F+L LGW +++Y+TRGFQ +G + +MI+KMI  DL RF ++
Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583

Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541
             V + GF++A   + +                  P        Y     T  ELF   I
Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643

Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598
              D     + D   +F I+  A+ I+  +L+LN+ IA+MG+T  ++AQE   +W+ Q  
Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703

Query: 599 ATTVMLERKLPRCL 612
            T +  E+   +C+
Sbjct: 704 ITILDTEKSFLKCM 717


>gi|74315348 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  240 bits (613), Expect = 3e-63
 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%)

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158
           ++  ELV    T   + GQTALHIA+  +N+ LV  L+   A V A A G  F+++  R 
Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304

Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364

Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317
              R+  +W YGP+ S LYDL+ ID+  E+ S LE++   SS+      +L   P+  L+
Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423

Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377
             KW+++ +  F     +Y LYMI FT    YRP+                   L     
Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466

Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436
           E   D  R+ GE++S++G V      I    +   S    KT+    +  ++    SL +
Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523

Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496
           L T+V+  ++    V  M F+L LGW +++Y+TRGFQ +G + +MI+KMI  DL RF ++
Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583

Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541
             V + GF++A   + +                  P        Y     T  ELF   I
Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643

Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598
              D     + D   +F I+  A+ I+  +L+LN+ IA+MG+T  ++AQE   +W+ Q  
Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703

Query: 599 ATTVMLERKLPRCL 612
            T +  E+   +C+
Sbjct: 704 ITILDTEKSFLKCM 717


>gi|21735483 transient receptor potential cation channel, subfamily
           V, member 3 [Homo sapiens]
          Length = 790

 Score =  236 bits (602), Expect = 6e-62
 Identities = 184/633 (29%), Positives = 307/633 (48%), Gaps = 75/633 (11%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQR---------------GA 77
           L K    ++KR L+  +  A  E  +  L +LL++     R+R                 
Sbjct: 107 LAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASD 166

Query: 78  LGETALHIAALYDN---LEAALVLMEAAPE------LVFEPTTCEAFAGQTALHIAVVNQ 128
            G+T L  A L  N    E   +L+  A E       +    T EA+ GQTAL+IA+  +
Sbjct: 167 TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERR 226

Query: 129 NVNLVRALLTRRASVSARATGTAFR-RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG- 186
             ++   L+   A V+A A G  F  +      YFGE PL+ AAC N  EIV+LL+EH  
Sbjct: 227 QGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQ 286

Query: 187 ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGL 241
            DI ++DS GN +LH L+      +    F  +MY+++L   G+ +    L+   N+ GL
Sbjct: 287 TDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE----LETTRNNDGL 342

Query: 242 TPFKLAGVEGNTVMFQHLMQK-----------RRHIQWTYGPLTSILYDLTEIDSWGEEL 290
           TP +LA   G   + ++++ +           R+   W YGP++S LYDLT +D+  +  
Sbjct: 343 TPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDN- 401

Query: 291 SFLELVVSSDKREAR-QILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVY 349
           S LE+ V +   + R ++L   P+  L+  KW K+ +  F +    Y  Y I  T    Y
Sbjct: 402 SVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY 461

Query: 350 RPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFR 409
           RP           R+   +   L   A   +   ++L+G +  ++ A+ I + E   IF 
Sbjct: 462 RP-----------REEEAIPHPL---ALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFL 507

Query: 410 VGASRYFGKTILGGP-FHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYF 468
           +  S    ++IL    FH +    A LV++++ + L      +  +  A+ LGW +++Y+
Sbjct: 508 LRPSDL--QSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY 565

Query: 469 TRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ-----TEDPTSLGQF 523
           TRGFQ +G +++MIQK+I  D+++F ++  V +LGF  A   + +      +D +S G F
Sbjct: 566 TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSF 625

Query: 524 YDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHW 583
            D   A+   F+L + + D     +   P +F  +   + I+  +L+LN+ IA+MG+T  
Sbjct: 626 SD---AVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVE 682

Query: 584 RVAQERDELWRAQVVATTVMLERKLPRCLWPRS 616
            V++E + +WR Q   T +  E+ LP   W RS
Sbjct: 683 NVSKESERIWRLQRARTILEFEKMLPE--WLRS 713


>gi|22547180 transient receptor potential cation channel, subfamily
           V, member 4 isoform b [Homo sapiens]
          Length = 811

 Score =  206 bits (525), Expect = 5e-53
 Identities = 169/569 (29%), Positives = 250/569 (43%), Gaps = 104/569 (18%)

Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR-RSPRNLIYF 162
           E +  P     + GQTALHIA+  +  + V  L+ + A V A+A G  F+ +      YF
Sbjct: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284

Query: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214
           GE PLS AAC N   IV  L E+    AD+R QDS GNTVLH L+      + N  F  +
Sbjct: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344

Query: 215 MYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLT 274
           MY+LLL           L+ V N+ GL+P  +A   G            RH         
Sbjct: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKI--------GNRH--------- 387

Query: 275 SILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAA 334
                                          ++L   P+ EL+  KW K+G   F I   
Sbjct: 388 -------------------------------EMLAVEPINELLRDKWRKFGAVSFYINVV 416

Query: 335 LYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIV 394
            YL  M+ FT    Y+PL+   G   +               Y T  D +RL GE++++ 
Sbjct: 417 SYLCAMVIFTLTAYYQPLE---GTPPYP--------------YRTTVDYLRLAGEVITLF 459

Query: 395 GAVIILLLEIPDIFRV---GASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEV 451
             V+     I D+F     G +  F    + G F ++   Y+ LV+V+  + L      +
Sbjct: 460 TGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVSAALYLAGIEAYL 515

Query: 452 VPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYII 511
             M FALVLGW + +YFTRG ++ G ++IMIQK++F DL RF  +  + ++G+ASA   +
Sbjct: 516 AVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSL 575

Query: 512 FQ--------TEDPT--------SLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMF 555
                      ED T        S      +   L   F+L + + D         P +F
Sbjct: 576 LNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF 635

Query: 556 SIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWP- 614
            I+   + I+  +L+LN+ IA+MG+T  +V++E   +W+ Q   T + +ER  P  L   
Sbjct: 636 IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKA 695

Query: 615 -RSG----ICGCEFGLGD-RWFLRVENHN 637
            RSG    +     G  D RW  RV+  N
Sbjct: 696 FRSGEMVTVGKSSDGTPDRRWCFRVDEVN 724


>gi|20127551 transient receptor potential cation channel, subfamily
           V, member 2 [Homo sapiens]
          Length = 764

 Score =  204 bits (518), Expect = 3e-52
 Identities = 178/621 (28%), Positives = 287/621 (46%), Gaps = 82/621 (13%)

Query: 76  GALGETALHIAALY--DNLEAALVLM------EAAPE-LVFEPTTCEAFAGQTALHIAVV 126
           G+ G+T L  A L   D + A ++ +         P+ LV    T + + G +ALHIA+ 
Sbjct: 113 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 172

Query: 127 NQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG 186
            +++  V+ L+   A+V ARA G  F++      YFGE PLS AAC    ++V  L+E+ 
Sbjct: 173 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 232

Query: 187 ---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNH 238
              A ++A DS GNTVLH L++       N      MY+ LL           L+ + N 
Sbjct: 233 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 292

Query: 239 QGLTPFKLAGVEGNTVMFQHLMQK---------RRHIQWTYGPLTSILYDLTEIDSWGEE 289
           Q LTP KLA  EG   +F+H++Q+         R+  +W YGP+   LYDL  +DS  EE
Sbjct: 293 QDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSC-EE 351

Query: 290 LSFLELVV---SSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTC 346
            S LE++     S  R    +LE  P+ +L+  KW+    P F +     L+YM  FT  
Sbjct: 352 NSVLEIIAFHCKSPHRHRMVVLE--PLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAV 408

Query: 347 CVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPD 406
             ++P              T+ +Q       E    ++ L G ++ ++G + +L+ ++  
Sbjct: 409 AYHQP--------------TLKKQAAPHLKAEVGNSML-LTGHILILLGGIYLLVGQLWY 453

Query: 407 IFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVM 466
            +R     +   + +   F ++ +  A L +V+ V+        +  +  ALVLGW +++
Sbjct: 454 FWRRHV--FIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLL 511

Query: 467 YFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ----TEDPT---- 518
           Y+TRGFQ  G +++MIQK+I  DL+RF  +  V + GFA A   + Q     E PT    
Sbjct: 512 YYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNA 571

Query: 519 -----------SLGQFYDYPMALFTTFELF-LTVIDAPANYDVDLPF--MFSIVNFAFAI 564
                        G    Y   L  + ELF  T+      +   L F  M  ++  A+ +
Sbjct: 572 TESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVL 631

Query: 565 IATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFG 624
           +  +L+LN+ IA+M +T   VA +   +W+ Q   + + +E     C   +    G    
Sbjct: 632 LTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWC--RKKQRAGVMLT 689

Query: 625 LG--------DRWFLRVENHN 637
           +G        +RW  RVE  N
Sbjct: 690 VGTKPDGSPDERWCFRVEEVN 710


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA Y  +  A +L+E                G T LH+AV + N+++V+ LL 
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
           R               SP +  + G  PL  AA  N  E+ R L+++G    A+   G T
Sbjct: 624 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 670

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254
            LH+   + +     +M  LLLS   +G+       + N  GLTP  L   EG+     V
Sbjct: 671 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 719

Query: 255 MFQHLMQKRRHIQWTYGPL 273
           + +H +      +  Y PL
Sbjct: 720 LIKHGVMVDATTRMGYTPL 738



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 48  PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107
           P L  +  ND +    +LL    +       G T LHIAA Y+NL  A +L+     + F
Sbjct: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P       G T LHIA    NV +VR LL R A +  +                   PL
Sbjct: 268 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 309

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227
             AA      I  +L++HGA I+A+   G + +H+     +         LLL YD   D
Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 365

Query: 228 HLQPLDLVPNH 238
            +    L P H
Sbjct: 366 DITLDHLTPLH 376



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 62/279 (22%), Positives = 106/279 (37%), Gaps = 70/279 (25%)

Query: 40  QQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLM 99
           ++K    +  LRA++  +L      L +   D+      G   LH+A+   +++  + L+
Sbjct: 40  KKKADAATSFLRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELL 98

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159
               E++ E TT +   G TALHIA +     +VR L+   A+V+A++            
Sbjct: 99  HK--EIILETTTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK---------- 143

Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN-- 217
              G  PL  AA  N  E+V+ L+E+GA+       G T L + + Q ++     + N  
Sbjct: 144 ---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200

Query: 218 -----------------------LLLSYDGHGDHLQPLDLVPNH---------------- 238
                                  +LL  D + D L      P H                
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260

Query: 239 ----------QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267
                      G+TP  +A   GN +M + L+ +   I+
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A ++   +V+  L+     +   +G +   ALHIAA  D+   A VL++  P   
Sbjct: 179 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 230

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P       G T LHIA   +N+N+ + LL R ASV+          +P+N    G  P
Sbjct: 231 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 275

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           L  A+   +  +VRLL++ GA I  +     T LH
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 310



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92
           LD+   ++ K   E   L  +  N    + ++LLD    ++ +   G + +H+AA  D+L
Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 351

Query: 93  EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152
           +   +L++   E+  +  T +     T LH+A    +  + + LL + A  ++RA     
Sbjct: 352 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 403

Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
                     G  PL  A   N   ++ LL++ GA I A    G T LH+          
Sbjct: 404 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 443

Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
                   S+ GH   ++ L        V N +  TP  +A   G+T + ++L+Q +  +
Sbjct: 444 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 23/193 (11%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A   N+L +++ LLL            G T LHIAA  + +E A  L++      
Sbjct: 604 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 660

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
                 E+  G T LH+A    +  +V  LL+++A+      G    +S       G  P
Sbjct: 661 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN------GNLGNKS-------GLTP 704

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226
           L   A      +  +LI+HG  + A   +G T LH+     N     ++   LL +    
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN----IKLVKFLLQHQADV 760

Query: 227 DHLQPLDLVPNHQ 239
           +    L   P HQ
Sbjct: 761 NAKTKLGYSPLHQ 773



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LLL     +      G T LH+A+   +L     L++  A+P 
Sbjct: 406 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +            +T LH+A    +  + + LL  +A V+A+A                +
Sbjct: 465 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 504

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
            PL  AA +    +V+LL+E+ A+     + G+T LHI
Sbjct: 505 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 46/156 (29%), Positives = 70/156 (44%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A++E    ++  LLL    +       G T LH+ A   ++  A VL++    ++
Sbjct: 670 TPLHLAAQEGHAEMVA-LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--VM 726

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
            + TT     G T LH+A    N+ LV+ LL  +A V+A+                G  P
Sbjct: 727 VDATTR---MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK-------------LGYSP 770

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  AA     +IV LL+++GA      S G T L I
Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 806



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 44/188 (23%), Positives = 75/188 (39%), Gaps = 29/188 (15%)

Query: 73  RQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132
           R++ A   T+   AA   NL+ AL  +    ++     TC    G   LH+A    +V +
Sbjct: 39  RKKKADAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKM 93

Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192
           V  LL +   +                   G   L  AA    +E+VR L+ +GA++ AQ
Sbjct: 94  VVELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQ 140

Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
              G T L++   + +     ++   LL    + +       V    G TP  +A  +G+
Sbjct: 141 SQKGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGH 189

Query: 253 TVMFQHLM 260
             +  HL+
Sbjct: 190 ENVVAHLI 197


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA Y  +  A +L+E                G T LH+AV + N+++V+ LL 
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
           R               SP +  + G  PL  AA  N  E+ R L+++G    A+   G T
Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254
            LH+   + +     +M  LLLS   +G+       + N  GLTP  L   EG+     V
Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686

Query: 255 MFQHLMQKRRHIQWTYGPL 273
           + +H +      +  Y PL
Sbjct: 687 LIKHGVMVDATTRMGYTPL 705



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 48  PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107
           P L  +  ND +    +LL    +       G T LHIAA Y+NL  A +L+     + F
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P       G T LHIA    NV +VR LL R A +  +                   PL
Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227
             AA      I  +L++HGA I+A+   G + +H+     +         LLL YD   D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332

Query: 228 HLQPLDLVPNH 238
            +    L P H
Sbjct: 333 DITLDHLTPLH 343



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A ++   +V+  L+     +   +G +   ALHIAA  D+   A VL++  P   
Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P       G T LHIA   +N+N+ + LL R ASV+          +P+N    G  P
Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           L  A+   +  +VRLL++ GA I  +     T LH
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L      L +   D+      G   LH+A+   +++  + L+    E++ E 
Sbjct: 17  LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73

Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169
           TT +   G TALHIA +     +VR L+   A+V+A++               G  PL  
Sbjct: 74  TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117

Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217
           AA  N  E+V+ L+E+GA+       G T L + + Q ++     + N            
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177

Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238
                        +LL  D + D L      P H                          
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237

Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267
            G+TP  +A   GN +M + L+ +   I+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A   N+L +++ LLL            G T LHIAA  + +E A  L++      
Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161
                 E+  G T LH+A    +  +V  LL+++A+ +    G     +P +L+      
Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681

Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203
                              G  PL  A+   + ++V+ L++H AD+ A+  LG + LH  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
             Q +      +  N     +   D   PL +      ++   +  V  +   F  +  K
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319
            R    ++      + D++E +  GEEL    +   +++R++R + E+   KEL+ F
Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92
           LD+   ++ K   E   L  +  N    + ++LLD    ++ +   G + +H+AA  D+L
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318

Query: 93  EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152
           +   +L++   E+  +  T +     T LH+A    +  + + LL + A  ++RA     
Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370

Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
                     G  PL  A   N   ++ LL++ GA I A    G T LH+          
Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410

Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
                   S+ GH   ++ L        V N +  TP  +A   G+T + ++L+Q +  +
Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LLL     +      G T LH+A+   +L     L++  A+P 
Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +            +T LH+A    +  + + LL  +A V+A+A                +
Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
            PL  AA +    +V+LL+E+ A+     + G+T LHI
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%)

Query: 75  RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134
           R A   T+   AA   NL+ AL  +    ++     TC    G   LH+A    +V +V 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62

Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194
            LL +   +                   G   L  AA    +E+VR L+ +GA++ AQ  
Sbjct: 63  ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109

Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254
            G T L++   + +     ++   LL    + +       V    G TP  +A  +G+  
Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158

Query: 255 MFQHLM 260
           +  HL+
Sbjct: 159 VVAHLI 164


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA Y  +  A +L+E                G T LH+AV + N+++V+ LL 
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
           R               SP +  + G  PL  AA  N  E+ R L+++G    A+   G T
Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254
            LH+   + +     +M  LLLS   +G+       + N  GLTP  L   EG+     V
Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686

Query: 255 MFQHLMQKRRHIQWTYGPL 273
           + +H +      +  Y PL
Sbjct: 687 LIKHGVMVDATTRMGYTPL 705



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 48  PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107
           P L  +  ND +    +LL    +       G T LHIAA Y+NL  A +L+     + F
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P       G T LHIA    NV +VR LL R A +  +                   PL
Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227
             AA      I  +L++HGA I+A+   G + +H+     +         LLL YD   D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332

Query: 228 HLQPLDLVPNH 238
            +    L P H
Sbjct: 333 DITLDHLTPLH 343



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A ++   +V+  L+     +   +G +   ALHIAA  D+   A VL++  P   
Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P       G T LHIA   +N+N+ + LL R ASV+          +P+N    G  P
Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           L  A+   +  +VRLL++ GA I  +     T LH
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L      L +   D+      G   LH+A+   +++  + L+    E++ E 
Sbjct: 17  LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73

Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169
           TT +   G TALHIA +     +VR L+   A+V+A++               G  PL  
Sbjct: 74  TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117

Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217
           AA  N  E+V+ L+E+GA+       G T L + + Q ++     + N            
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177

Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238
                        +LL  D + D L      P H                          
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237

Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267
            G+TP  +A   GN +M + L+ +   I+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A   N+L +++ LLL            G T LHIAA  + +E A  L++      
Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161
                 E+  G T LH+A    +  +V  LL+++A+ +    G     +P +L+      
Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681

Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203
                              G  PL  A+   + ++V+ L++H AD+ A+  LG + LH  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
             Q +      +  N     +   D   PL +      ++   +  V  +   F  +  K
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319
            R    ++      + D++E +  GEEL    +   +++R++R + E+   KEL+ F
Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92
           LD+   ++ K   E   L  +  N    + ++LLD    ++ +   G + +H+AA  D+L
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318

Query: 93  EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152
           +   +L++   E+  +  T +     T LH+A    +  + + LL + A  ++RA     
Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370

Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
                     G  PL  A   N   ++ LL++ GA I A    G T LH+          
Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410

Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
                   S+ GH   ++ L        V N +  TP  +A   G+T + ++L+Q +  +
Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LLL     +      G T LH+A+   +L     L++  A+P 
Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +            +T LH+A    +  + + LL  +A V+A+A                +
Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
            PL  AA +    +V+LL+E+ A+     + G+T LHI
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%)

Query: 75  RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134
           R A   T+   AA   NL+ AL  +    ++     TC    G   LH+A    +V +V 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62

Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194
            LL +   +                   G   L  AA    +E+VR L+ +GA++ AQ  
Sbjct: 63  ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109

Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254
            G T L++   + +     ++   LL    + +       V    G TP  +A  +G+  
Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158

Query: 255 MFQHLM 260
           +  HL+
Sbjct: 159 VVAHLI 164


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA Y  +  A +L+E                G T LH+AV + N+++V+ LL 
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
           R               SP +  + G  PL  AA  N  E+ R L+++G    A+   G T
Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254
            LH+   + +     +M  LLLS   +G+       + N  GLTP  L   EG+     V
Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686

Query: 255 MFQHLMQKRRHIQWTYGPL 273
           + +H +      +  Y PL
Sbjct: 687 LIKHGVMVDATTRMGYTPL 705



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 48  PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107
           P L  +  ND +    +LL    +       G T LHIAA Y+NL  A +L+     + F
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P       G T LHIA    NV +VR LL R A +  +                   PL
Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227
             AA      I  +L++HGA I+A+   G + +H+     +         LLL YD   D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332

Query: 228 HLQPLDLVPNH 238
            +    L P H
Sbjct: 333 DITLDHLTPLH 343



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A ++   +V+  L+     +   +G +   ALHIAA  D+   A VL++  P   
Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P       G T LHIA   +N+N+ + LL R ASV+          +P+N    G  P
Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           L  A+   +  +VRLL++ GA I  +     T LH
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L      L +   D+      G   LH+A+   +++  + L+    E++ E 
Sbjct: 17  LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73

Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169
           TT +   G TALHIA +     +VR L+   A+V+A++               G  PL  
Sbjct: 74  TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117

Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217
           AA  N  E+V+ L+E+GA+       G T L + + Q ++     + N            
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177

Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238
                        +LL  D + D L      P H                          
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237

Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267
            G+TP  +A   GN +M + L+ +   I+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A   N+L +++ LLL            G T LHIAA  + +E A  L++      
Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161
                 E+  G T LH+A    +  +V  LL+++A+ +    G     +P +L+      
Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681

Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203
                              G  PL  A+   + ++V+ L++H AD+ A+  LG + LH  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
             Q +      +  N     +   D   PL +      ++   +  V  +   F  +  K
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319
            R    ++      + D++E +  GEEL    +   +++R++R + E+   KEL+ F
Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92
           LD+   ++ K   E   L  +  N    + ++LLD    ++ +   G + +H+AA  D+L
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318

Query: 93  EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152
           +   +L++   E+  +  T +     T LH+A    +  + + LL + A  ++RA     
Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370

Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
                     G  PL  A   N   ++ LL++ GA I A    G T LH+          
Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410

Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
                   S+ GH   ++ L        V N +  TP  +A   G+T + ++L+Q +  +
Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LLL     +      G T LH+A+   +L     L++  A+P 
Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +            +T LH+A    +  + + LL  +A V+A+A                +
Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
            PL  AA +    +V+LL+E+ A+     + G+T LHI
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%)

Query: 75  RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134
           R A   T+   AA   NL+ AL  +    ++     TC    G   LH+A    +V +V 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62

Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194
            LL +   +                   G   L  AA    +E+VR L+ +GA++ AQ  
Sbjct: 63  ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109

Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254
            G T L++   + +     ++   LL    + +       V    G TP  +A  +G+  
Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158

Query: 255 MFQHLM 260
           +  HL+
Sbjct: 159 VVAHLI 164


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA Y  +  A +L+E                G T LH+AV + N+++V+ LL 
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
           R               SP +  + G  PL  AA  N  E+ R L+++G    A+   G T
Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254
            LH+   + +     +M  LLLS   +G+       + N  GLTP  L   EG+     V
Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686

Query: 255 MFQHLMQKRRHIQWTYGPL 273
           + +H +      +  Y PL
Sbjct: 687 LIKHGVMVDATTRMGYTPL 705



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 48  PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107
           P L  +  ND +    +LL    +       G T LHIAA Y+NL  A +L+     + F
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P       G T LHIA    NV +VR LL R A +  +                   PL
Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227
             AA      I  +L++HGA I+A+   G + +H+     +         LLL YD   D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332

Query: 228 HLQPLDLVPNH 238
            +    L P H
Sbjct: 333 DITLDHLTPLH 343



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A ++   +V+  L+     +   +G +   ALHIAA  D+   A VL++  P   
Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P       G T LHIA   +N+N+ + LL R ASV+          +P+N    G  P
Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           L  A+   +  +VRLL++ GA I  +     T LH
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L      L +   D+      G   LH+A+   +++  + L+    E++ E 
Sbjct: 17  LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73

Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169
           TT +   G TALHIA +     +VR L+   A+V+A++               G  PL  
Sbjct: 74  TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117

Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217
           AA  N  E+V+ L+E+GA+       G T L + + Q ++     + N            
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177

Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238
                        +LL  D + D L      P H                          
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237

Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267
            G+TP  +A   GN +M + L+ +   I+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A   N+L +++ LLL            G T LHIAA  + +E A  L++      
Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161
                 E+  G T LH+A    +  +V  LL+++A+ +    G     +P +L+      
Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681

Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203
                              G  PL  A+   + ++V+ L++H AD+ A+  LG + LH  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
             Q +      +  N     +   D   PL +      ++   +  V  +   F  +  K
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319
            R    ++      + D++E +  GEEL    +   +++R++R + E+   KEL+ F
Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 33  LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92
           LD+   ++ K   E   L  +  N    + ++LLD    ++ +   G + +H+AA  D+L
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318

Query: 93  EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152
           +   +L++   E+  +  T +     T LH+A    +  + + LL + A  ++RA     
Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370

Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
                     G  PL  A   N   ++ LL++ GA I A    G T LH+          
Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410

Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
                   S+ GH   ++ L        V N +  TP  +A   G+T + ++L+Q +  +
Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LLL     +      G T LH+A+   +L     L++  A+P 
Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +            +T LH+A    +  + + LL  +A V+A+A                +
Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
            PL  AA +    +V+LL+E+ A+     + G+T LHI
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%)

Query: 75  RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134
           R A   T+   AA   NL+ AL  +    ++     TC    G   LH+A    +V +V 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62

Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194
            LL +   +                   G   L  AA    +E+VR L+ +GA++ AQ  
Sbjct: 63  ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109

Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254
            G T L++   + +     ++   LL    + +       V    G TP  +A  +G+  
Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158

Query: 255 MFQHLM 260
           +  HL+
Sbjct: 159 VVAHLI 164


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           ++PL  AS+     ++ QLLL            G T LHI+A    ++ A VL+EA    
Sbjct: 477 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 534

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165
                +     G T LH+A    ++++ + LL RRA+  +                 G  
Sbjct: 535 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 577

Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225
           PL  AA  +++++  LL+E GA   A    G T LHI      K    Q+ + LL+Y   
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 633

Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276
            +       +   QG+TP  LA  EG+T M   L+ K  +I   T   LTS+
Sbjct: 634 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LL+     ++     G T +H+AA   +L   L+L++  A+P+
Sbjct: 379 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +           G+TALH+A     V +VR LL   A V ARA                +
Sbjct: 438 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 477

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+ +   EIV+LL++H A   A  + G T LHI   +     A  +     ++  
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 536

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263
                     +   +G TP  +A   G+  + + L+Q+R
Sbjct: 537 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 565



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%)

Query: 3   GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62
           GF P A        + +   L  +      L  LH+  +K   +S  L    +++  V  
Sbjct: 142 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 201

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           +++++ T +       G T LHIAA Y N+  A +L+     + F      A  G T LH
Sbjct: 202 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 250

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
           +A    N N+V+ LL R   + A+                G  PL  AA    +++V LL
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 297

Query: 183 IEHGADIRAQDSLGNTVLHI 202
           +E GA + A+   G + LH+
Sbjct: 298 LERGAPLLARTKNGLSPLHM 317



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A+K   L V + LLL         G  G T LH+AA YDN + AL+L+E  A+P 
Sbjct: 544 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
                    A  G T LHIA     + +   LL   A  +              +   G 
Sbjct: 603 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 642

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+     ++V LL++ GA+I      G T LH+   +     A  +       D 
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
           H              G TP  +A   GN  M   L+++  ++
Sbjct: 703 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 733



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  AS+E    ++  LLLD   ++      G T+LH+AA  D +  A +L +   +  
Sbjct: 643 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 699

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
                     G T L +A    NV +V  LL + A+V+A+                G  P
Sbjct: 700 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 743

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  AA      I+ +L++HGA   A  + GNT L I
Sbjct: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 779



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A++     V+ +LLL+    +  R   G + LH+AA  D++E    L++    + 
Sbjct: 280 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 337

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
            +  T +     TALH+A    +  + + LL +RA+ +ARA               G  P
Sbjct: 338 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 380

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  A   N  +++ LL+++GA I+A    G T +H+
Sbjct: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 49/188 (26%), Positives = 84/188 (44%), Gaps = 27/188 (14%)

Query: 41  QKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100
           QK    +  LRA++  +L  + + L     D+      G  ALH+AA     E  + L++
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ 60

Query: 101 AAPELVFEPTTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRN 158
              EL+   ++ ++    G TALHIA +     +V+ L+   A+++A++           
Sbjct: 61  ---ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN--------- 108

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 218
               G  PL  AA  N  ++V+ L+E+GA+       G T L + + Q +     Q   +
Sbjct: 109 ----GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAI 160

Query: 219 LLSYDGHG 226
           LL  D  G
Sbjct: 161 LLENDTKG 168



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%)

Query: 52  ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111
           A+KE  + ++++LL      V      G TALHIA+L    E   VL++    +      
Sbjct: 50  AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 103

Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165
            ++  G T L++A    ++++V+ LL   A+ S  AT   F  +P  +     H      
Sbjct: 104 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 160

Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204
                         L  AA  +  +   LL++  H AD++++  +      G T LHI  
Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220

Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
              N   A  + N   + D                G+TP  +A   GNT M + L+ +
Sbjct: 221 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 267


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           ++PL  AS+     ++ QLLL            G T LHI+A    ++ A VL+EA    
Sbjct: 498 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 555

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165
                +     G T LH+A    ++++ + LL RRA+  +                 G  
Sbjct: 556 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 598

Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225
           PL  AA  +++++  LL+E GA   A    G T LHI      K    Q+ + LL+Y   
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 654

Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276
            +       +   QG+TP  LA  EG+T M   L+ K  +I   T   LTS+
Sbjct: 655 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LL+     ++     G T +H+AA   +L   L+L++  A+P+
Sbjct: 400 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +           G+TALH+A     V +VR LL   A V ARA                +
Sbjct: 459 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 498

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+ +   EIV+LL++H A   A  + G T LHI   +     A  +     ++  
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 557

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263
                     +   +G TP  +A   G+  + + L+Q+R
Sbjct: 558 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 586



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%)

Query: 3   GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62
           GF P A        + +   L  +      L  LH+  +K   +S  L    +++  V  
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           +++++ T +       G T LHIAA Y N+  A +L+     + F      A  G T LH
Sbjct: 223 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 271

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
           +A    N N+V+ LL R   + A+                G  PL  AA    +++V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 318

Query: 183 IEHGADIRAQDSLGNTVLHI 202
           +E GA + A+   G + LH+
Sbjct: 319 LERGAPLLARTKNGLSPLHM 338



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A+K   L V + LLL         G  G T LH+AA YDN + AL+L+E  A+P 
Sbjct: 565 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
                    A  G T LHIA     + +   LL   A  +              +   G 
Sbjct: 624 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 663

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+     ++V LL++ GA+I      G T LH+   +     A  +       D 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
           H              G TP  +A   GN  M   L+++  ++
Sbjct: 724 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  AS+E    ++  LLLD   ++      G T+LH+AA  D +  A +L +   +  
Sbjct: 664 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 720

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
                     G T L +A    NV +V  LL + A+V+A+                G  P
Sbjct: 721 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 764

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  AA      I+ +L++HGA   A  + GNT L I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 61/251 (24%)

Query: 47  SPLLRASKENDLSVLRQLL----------------------------LDCTCDVRQRGAL 78
           +PL  A++EN + V++ LL                            +    +   +G +
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191

Query: 79  GETALHIAALYDNLEAALVLM------EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132
              ALHIAA  D+ ++A +L+      +   +++   TT   F   T LHIA    NVN+
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNV 248

Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192
              LL R A+V   A         RN    G  PL  A+   +  +V+LL++ G  I A+
Sbjct: 249 ATLLLNRGAAVDFTA---------RN----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
              G T LH      +     Q+  LLL      +   PL L     GL+P  +A    +
Sbjct: 296 TRDGLTPLHCAARSGHD----QVVELLL------ERGAPL-LARTKNGLSPLHMAAQGDH 344

Query: 253 TVMFQHLMQKR 263
               +HL+Q +
Sbjct: 345 VECVKHLLQHK 355



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A++     V+ +LLL+    +  R   G + LH+AA  D++E    L++    + 
Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 358

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
            +  T +     TALH+A    +  + + LL +RA+ +ARA               G  P
Sbjct: 359 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 401

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  A   N  +++ LL+++GA I+A    G T +H+
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)

Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176
           G  ALH+A    +V LV+ LL R +SV +                 G   L  A+     
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-------------GNTALHIASLAGQA 110

Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHI 202
           E+V++L++ GA+I AQ   G T L++
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYM 136



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 27/179 (15%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L  + + L     D+      G  ALH+AA     E  + L++   EL+   
Sbjct: 36  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ---ELLGRG 87

Query: 110 TTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
           ++ ++    G TALHIA +     +V+ L+   A+++A++               G  PL
Sbjct: 88  SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-------------GFTPL 134

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226
             AA  N  ++V+ L+E+GA+       G T L + + Q +     Q   +LL  D  G
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAILLENDTKG 189



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%)

Query: 52  ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111
           A+KE  + ++++LL      V      G TALHIA+L    E   VL++    +      
Sbjct: 71  AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 124

Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165
            ++  G T L++A    ++++V+ LL   A+ S  AT   F  +P  +     H      
Sbjct: 125 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 181

Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204
                         L  AA  +  +   LL++  H AD++++  +      G T LHI  
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241

Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
              N   A  + N   + D                G+TP  +A   GNT M + L+ +
Sbjct: 242 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 288


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           ++PL  AS+     ++ QLLL            G T LHI+A    ++ A VL+EA    
Sbjct: 498 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 555

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165
                +     G T LH+A    ++++ + LL RRA+  +                 G  
Sbjct: 556 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 598

Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225
           PL  AA  +++++  LL+E GA   A    G T LHI      K    Q+ + LL+Y   
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 654

Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276
            +       +   QG+TP  LA  EG+T M   L+ K  +I   T   LTS+
Sbjct: 655 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A K+N + V+ +LL+     ++     G T +H+AA   +L   L+L++  A+P+
Sbjct: 400 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
           +           G+TALH+A     V +VR LL   A V ARA                +
Sbjct: 459 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 498

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+ +   EIV+LL++H A   A  + G T LHI   +     A  +     ++  
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 557

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263
                     +   +G TP  +A   G+  + + L+Q+R
Sbjct: 558 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 586



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%)

Query: 3   GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62
           GF P A        + +   L  +      L  LH+  +K   +S  L    +++  V  
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           +++++ T +       G T LHIAA Y N+  A +L+     + F      A  G T LH
Sbjct: 223 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 271

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
           +A    N N+V+ LL R   + A+                G  PL  AA    +++V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 318

Query: 183 IEHGADIRAQDSLGNTVLHI 202
           +E GA + A+   G + LH+
Sbjct: 319 LERGAPLLARTKNGLSPLHM 338



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A+K   L V + LLL         G  G T LH+AA YDN + AL+L+E  A+P 
Sbjct: 565 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
                    A  G T LHIA     + +   LL   A  +              +   G 
Sbjct: 624 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 663

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  A+     ++V LL++ GA+I      G T LH+   +     A  +       D 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
           H              G TP  +A   GN  M   L+++  ++
Sbjct: 724 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  AS+E    ++  LLLD   ++      G T+LH+AA  D +  A +L +   +  
Sbjct: 664 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 720

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
                     G T L +A    NV +V  LL + A+V+A+                G  P
Sbjct: 721 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 764

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  AA      I+ +L++HGA   A  + GNT L I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 61/251 (24%)

Query: 47  SPLLRASKENDLSVLRQLL----------------------------LDCTCDVRQRGAL 78
           +PL  A++EN + V++ LL                            +    +   +G +
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191

Query: 79  GETALHIAALYDNLEAALVLM------EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132
              ALHIAA  D+ ++A +L+      +   +++   TT   F   T LHIA    NVN+
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNV 248

Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192
              LL R A+V   A         RN    G  PL  A+   +  +V+LL++ G  I A+
Sbjct: 249 ATLLLNRGAAVDFTA---------RN----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
              G T LH      +     Q+  LLL      +   PL L     GL+P  +A    +
Sbjct: 296 TRDGLTPLHCAARSGHD----QVVELLL------ERGAPL-LARTKNGLSPLHMAAQGDH 344

Query: 253 TVMFQHLMQKR 263
               +HL+Q +
Sbjct: 345 VECVKHLLQHK 355



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A++     V+ +LLL+    +  R   G + LH+AA  D++E    L++    + 
Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 358

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
            +  T +     TALH+A    +  + + LL +RA+ +ARA               G  P
Sbjct: 359 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 401

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           L  A   N  +++ LL+++GA I+A    G T +H+
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)

Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176
           G  ALH+A    +V LV+ LL R +SV +                 G   L  A+     
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-------------GNTALHIASLAGQA 110

Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHI 202
           E+V++L++ GA+I AQ   G T L++
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYM 136



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 27/179 (15%)

Query: 50  LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109
           LRA++  +L  + + L     D+      G  ALH+AA     E  + L++   EL+   
Sbjct: 36  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ---ELLGRG 87

Query: 110 TTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
           ++ ++    G TALHIA +     +V+ L+   A+++A++               G  PL
Sbjct: 88  SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-------------GFTPL 134

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226
             AA  N  ++V+ L+E+GA+       G T L + + Q +     Q   +LL  D  G
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAILLENDTKG 189



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%)

Query: 52  ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111
           A+KE  + ++++LL      V      G TALHIA+L    E   VL++    +      
Sbjct: 71  AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 124

Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165
            ++  G T L++A    ++++V+ LL   A+ S  AT   F  +P  +     H      
Sbjct: 125 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 181

Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204
                         L  AA  +  +   LL++  H AD++++  +      G T LHI  
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241

Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
              N   A  + N   + D                G+TP  +A   GNT M + L+ +
Sbjct: 242 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 288


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 58/198 (29%), Positives = 90/198 (45%), Gaps = 29/198 (14%)

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           Q+LL  + DV  R    +T LHIAA    ++ A    EA   L+      +  AG+TALH
Sbjct: 91  QVLLKHSADVNARDKNWQTPLHIAAANKAVKCA----EALVPLLSNVNVSDR-AGRTALH 145

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
            A  + +  +V+ LL+R A+++A      F +  R  I++       AA +   E+V+LL
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINA------FDKKDRRAIHW-------AAYMGHIEVVKLL 192

Query: 183 IEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLT 242
           + HGA++  +D    T LH      +   +   Y L L  D +          PN  G T
Sbjct: 193 VSHGAEVTCKDKKSYTPLH--AAASSGMISVVKYLLDLGVDMN---------EPNAYGNT 241

Query: 243 PFKLAGVEGNTVMFQHLM 260
           P  +A   G  V+   L+
Sbjct: 242 PLHVACYNGQDVVVNELI 259



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 56/221 (25%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+     ++  +LL+    DV  +   G+T LH+ AL+     +  ++++   + 
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI- 332

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRSP 156
                CE   G T LHIA    +  L+  L+T  A  + R          A  + F    
Sbjct: 333 ----DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388

Query: 157 RNLIY----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQ 206
           R L+           FG   L  AA   + E + LL+  GAD   +D  G + LH     
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448

Query: 207 PNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLA 247
            N       Y  L +  G G  +  LD     +G TP   A
Sbjct: 449 CN-------YQCLFALVGSGASVNDLD----ERGCTPLHYA 478



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G TALH A    +     +L+E   + VF+ T   AF+    LH AV+N N      L+ 
Sbjct: 756 GYTALHWACYNGHETCVELLLE---QEVFQKTEGNAFS---PLHCAVINDNEGAAEMLID 809

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
              +    AT +            G  PL  AA  +  E ++LL+ H A + + DS G T
Sbjct: 810 TLGASIVNATDSK-----------GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858

Query: 199 VL 200
            L
Sbjct: 859 PL 860



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 50/181 (27%), Positives = 75/181 (41%), Gaps = 28/181 (15%)

Query: 75  RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134
           R + G T +H++A   ++     L+++A  +   P T +   G TALH A  N +   V 
Sbjct: 715 RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNH-GYTALHWACYNGHETCVE 773

Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH-GADI-RAQ 192
            LL +   V  +  G AF             PL  A   ++E    +LI+  GA I  A 
Sbjct: 774 LLLEQ--EVFQKTEGNAF------------SPLHCAVINDNEGAAEMLIDTLGASIVNAT 819

Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
           DS G T LH        T   +   LLLS++   + +       +  G TP  +A   G 
Sbjct: 820 DSKGRTPLHAAAF----TDHVECLQLLLSHNAQVNSV-------DSTGKTPLMMAAENGQ 868

Query: 253 T 253
           T
Sbjct: 869 T 869



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 25/181 (13%)

Query: 83  LHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142
           LH A + DN  AA +L++     +   T  +   G+T LH A    +V  ++ LL+  A 
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSK---GRTPLHAAAFTDHVECLQLLLSHNAQ 848

Query: 143 VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG-ADIRAQDSLGNTVLH 201
           V++  +              G+ PL  AA       V +L+    A++  QD+  NT LH
Sbjct: 849 VNSVDST-------------GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895

Query: 202 ILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
           +   + ++T A  +   +          + L    N    TP  +A   G T++ Q L+ 
Sbjct: 896 LACSKGHETSALLILEKITD--------RNLINATNAALQTPLHVAARNGLTMVVQELLG 947

Query: 262 K 262
           K
Sbjct: 948 K 948



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 36/126 (28%), Positives = 58/126 (46%), Gaps = 17/126 (13%)

Query: 78  LGETALHIAALYDNLEAALVLM-EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRAL 136
           L  T +H AA   + E   +L+  A P+   +    +   GQT L ++V+N + + V +L
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVD---IQDGNGQTPLMLSVLNGHTDCVYSL 672

Query: 137 LTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLG 196
           L + A+V A+               +G   L   A    EE V  L++HGA    +DS G
Sbjct: 673 LNKGANVDAKDK-------------WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719

Query: 197 NTVLHI 202
            T +H+
Sbjct: 720 RTPIHL 725



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 45/163 (27%), Positives = 66/163 (40%), Gaps = 32/163 (19%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+    +SV++ LL D   D+ +  A G T LH+A  Y+  +           +V
Sbjct: 208 TPLHAAASSGMISVVKYLL-DLGVDMNEPNAYGNTPLHVAC-YNGQDV----------VV 255

Query: 107 FEPTTCEAFAGQ------TALHIAVVNQNVNLVRALLT-RRASVSARATGTAFRRSPRNL 159
            E   C A   Q      T LH A  + +  L   LL    A V+ ++            
Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD---------- 305

Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
              G+ PL   A        + +I+ GA I  +D  GNT LHI
Sbjct: 306 ---GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 2/100 (2%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           ++PL+ A++    + +  L+   + ++  +     TALH+A    +  +AL+++E   + 
Sbjct: 857 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDR 916

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSA 145
                T  A   QT LH+A  N    +V+ LL + ASV A
Sbjct: 917 NLINATNAAL--QTPLHVAARNGLTMVVQELLGKGASVLA 954



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 15/96 (15%)

Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177
           +T LH A    +  ++  L+   A V+A+ +                 PL  A    SEE
Sbjct: 42  RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLT-------------PLHRAVASCSEE 88

Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFAC 213
            V++L++H AD+ A+D    T LH  I   NK   C
Sbjct: 89  AVQVLLKHSADVNARDKNWQTPLH--IAAANKAVKC 122



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 32/174 (18%)

Query: 53  SKENDLSVLRQLL-LDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111
           + E  L VL +    D   D   R  +  + LH+AA + + +A  VL+++  +L    ++
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATI--SPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582

Query: 112 CEAFAGQTALHIA-----------VVNQNVN-LVRALLTRRASVSARATG--------TA 151
                G+T L +A           ++NQ  + LV+  + +R  + A AT           
Sbjct: 583 -----GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637

Query: 152 FRRSPRNLIYF----GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
               P+N +      G+ PL  +      + V  L+  GA++ A+D  G T LH
Sbjct: 638 GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALH 691


>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 52/155 (33%), Positives = 68/155 (43%), Gaps = 18/155 (11%)

Query: 49  LLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIA-ALYDNLEAALVLMEAAPELVF 107
           LLRA  + D    R+LL     +  +RGA  E     A A      AA      AP    
Sbjct: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPV--- 69

Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167
            P  C   AG TAL  A    +  LVR LL R ASV++R              ++G   L
Sbjct: 70  -PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRN-------------HYGWSAL 115

Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
             AA      +  LL++HGAD+ AQ+ LG +VL +
Sbjct: 116 MQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTV 150



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 57/254 (22%), Positives = 95/254 (37%), Gaps = 48/254 (18%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           S L++A++   +SV   LLLD   DV  +  LG + L +A+   +L    +L+EA   + 
Sbjct: 113 SALMQAARFGHVSVAH-LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171

Query: 107 FEPTTCEAFA---------GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPR 157
               + E              TAL  A+ + +  +VR L+   A  +  A          
Sbjct: 172 HHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTV------- 224

Query: 158 NLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI------------- 204
                G  PL  AA      + + L+E GA+      L  T   + +             
Sbjct: 225 -----GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDP 279

Query: 205 ------------LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
                        +P+   A +M N  L  +   +    ++LV N  G TP  LA V G 
Sbjct: 280 LTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLV-NGDGATPLMLAAVTGQ 338

Query: 253 TVMFQHLMQKRRHI 266
             + Q L+++   +
Sbjct: 339 LALVQLLVERHADV 352



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 12/89 (13%)

Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176
           G T L +A V   + LV+ L+ R A V  + +              G   L  A    ++
Sbjct: 326 GATPLMLAAVTGQLALVQLLVERHADVDKQDS------------VHGWTALMQATYHGNK 373

Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILIL 205
           EIV+ L+  GAD+  +   G T   +++L
Sbjct: 374 EIVKYLLNQGADVTLRAKNGYTAFDLVML 402


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 19/155 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL RA        + Q+L+  + DV  R    +T LH+AA    ++ A V++      +
Sbjct: 51  TPLHRAVASRSEEAV-QVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIP-----L 104

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
                     G+TALH A +N +V +V  LL + A+++A      F +  R  +++    
Sbjct: 105 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA------FDKKDRRALHW---- 154

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
              AA +   ++V LLI HGA++  +D  G T LH
Sbjct: 155 ---AAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 28/180 (15%)

Query: 82  ALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRA 141
           ALH AA   +L+   +L+    E+     TC+   G T LH A  N  +N+V+ LL    
Sbjct: 151 ALHWAAYMGHLDVVALLINHGAEV-----TCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205

Query: 142 SVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
            +               +  +G   L  A     + +V  LI++GA++   ++ G T LH
Sbjct: 206 EID-------------EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252

Query: 202 ILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
                 +     +    LL  +G   ++Q  D      G +P  +  V G     Q L+Q
Sbjct: 253 FAAASTHGALCLE----LLVNNGADVNIQSKD------GKSPLHMTAVHGRFTRSQTLIQ 302



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 64/292 (21%), Positives = 109/292 (37%), Gaps = 38/292 (13%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           +SPL  A+       L ++LL    D+  R   G TAL +AA   + E    L+     +
Sbjct: 543 KSPLHLAAYNGHHQAL-EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165
             +    +    +T LH +V+N +   +R LL    +  A     A  ++P  L     H
Sbjct: 602 FVKDNVTK----RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657

Query: 166 -----------------------PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
                                   L        EE V++L+E    I  +DS G T LH 
Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717

Query: 203 LILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262
              + + T+  ++  + LS +             ++QG TP   A   GN    + L+++
Sbjct: 718 AAARGHATWLSELLQMALSEED--------CCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769

Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVK 314
           +   ++   P T +      I+  G   S L   + S     R    +TP++
Sbjct: 770 KCFRKFIGNPFTPL--HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLR 819



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 33/119 (27%), Positives = 52/119 (43%), Gaps = 18/119 (15%)

Query: 83  LHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142
           LH+AAL  + +    L+ +     FE  T + F G+T LH A    NV  ++ L      
Sbjct: 351 LHLAALNAHSDCCRKLLSSG----FEIDTPDKF-GRTCLHAAAAGGNVECIKLL------ 399

Query: 143 VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
              +++G  F +  +     G  PL +AA       +  L+  GA++   D  G T LH
Sbjct: 400 ---QSSGADFHKKDK----CGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALH 451



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 40/151 (26%), Positives = 61/151 (40%), Gaps = 28/151 (18%)

Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177
           +T LH+A    +  ++  L+   A V+A+                   PL  A    SEE
Sbjct: 17  RTPLHVAAFLGDAEIIELLILSGARVNAKDN-------------MWLTPLHRAVASRSEE 63

Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ--MYNLLLSYDGHGDHLQPLDLV 235
            V++LI+H AD+ A+D    T LH  +   NK   C   +  LL S +           V
Sbjct: 64  AVQVLIKHSADVNARDKNWQTPLH--VAAANKAVKCAEVIIPLLSSVN-----------V 110

Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
            +  G T    A + G+  M   L+ K  +I
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANI 141



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 25/175 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+     ++  +LL++   DV  +   G++ LH+ A++     +  L++   E+ 
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI- 307

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSA----------RATGTAFRRSP 156
                C    G T LH+A    +  L+  L T  A  +            A   A     
Sbjct: 308 ----DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363

Query: 157 RNLIY----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201
           R L+           FG   L  AA   + E ++LL   GAD   +D  G T LH
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 54/217 (24%), Positives = 89/217 (41%), Gaps = 25/217 (11%)

Query: 51  RASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPT 110
           R  KE + ++  + LL    +   R   G  ++H AA Y + +   +L+E      FE +
Sbjct: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT-NSGFEES 537

Query: 111 TCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFA 170
             ++ A ++ LH+A  N +   +  LL     +  R                G   L  A
Sbjct: 538 --DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK-------------GRTALDLA 582

Query: 171 ACVNSEEIVRLLIEHGADIRAQDSL-GNTVLHILILQPNKTFACQMYNLLLSYDGHGDHL 229
           A     E V  LI  GA I  +D++   T LH  ++  N    C    LLL      D+ 
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI--NGHTLC--LRLLLEI---ADNP 635

Query: 230 QPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
           + +D V + +G TP  LA   G+      L++K  ++
Sbjct: 636 EAVD-VKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV 671



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 41/163 (25%), Positives = 63/163 (38%), Gaps = 31/163 (19%)

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           Q+LL+    +  + + G T LH AA   +      L++ A  L  E    +   G T LH
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA--LSEEDCCFKDNQGYTPLH 752

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH----------------- 165
            A  N N N +  LL ++     +  G  F  +P +     +H                 
Sbjct: 753 WACYNGNENCIEVLLEQKCF--RKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSIVS 808

Query: 166 --------PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200
                   PL  AA  +  E ++LL+ H A + A D+ G T L
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 20/157 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+    ++V++ LL +   ++ +    G TALHIA  Y+  +A +  +      V
Sbjct: 183 TPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIAC-YNGQDAVVNELIDYGANV 240

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR-ASVSARATGTAFRRSPRNLIYFGEH 165
            +P       G T LH A  + +  L   LL    A V+ ++               G+ 
Sbjct: 241 NQPNN----NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-------------GKS 283

Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
           PL   A        + LI++G +I   D  GNT LH+
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 56/241 (23%), Positives = 91/241 (37%), Gaps = 56/241 (23%)

Query: 65  LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124
           LL    ++      G T LH AA   N+E   +L  +  +   +   C    G+T LH A
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF-HKKDKC----GRTPLHYA 420

Query: 125 VVNQNVNLVRALLTRRASVS-------ARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177
             N + + +  L+T  A+V+             A     RN    G       A  NSEE
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN------AHDNSEE 474

Query: 178 IVR--------------LLIEHGADIRAQDSLGNTVLH------------ILILQPNKTF 211
           + R               L+++ A+   +D  G   +H            +L+ + N  F
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534

Query: 212 ------ACQMYNLLLSYDGHGDHLQPL-----DL-VPNHQGLTPFKLAGVEGNTVMFQHL 259
                 A +    L +Y+GH   L+ L     DL + + +G T   LA  +G+T   + L
Sbjct: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594

Query: 260 M 260
           +
Sbjct: 595 I 595


>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
          Length = 319

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 55/187 (29%), Positives = 85/187 (45%), Gaps = 34/187 (18%)

Query: 50  LRASKENDLSVLRQLLLDCT----CDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           L+A+ EN L V+ + L D      CD  +R     TALH A L  +L     LMEA  ++
Sbjct: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKR-----TALHRACLEGHLAIVEKLMEAGAQI 179

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRS 155
            F           TA+H A    N+++++ LL + A +SAR          A  T     
Sbjct: 180 EFRD-----MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC 234

Query: 156 PRNLIYF----------GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILIL 205
             +LI            G+ PL  A  +N  +++RLLI +GAD+  ++  G T + +++ 
Sbjct: 235 AEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294

Query: 206 QPNKTFA 212
             N T A
Sbjct: 295 WQNGTKA 301



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 7/109 (6%)

Query: 39  LQQKRILESPLLR-ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALV 97
           ++ + +LES  +  AS+  +L VL+ LLL+    +  R  L  TALH+A    + E A  
Sbjct: 179 IEFRDMLESTAIHWASRGGNLDVLK-LLLNKGAKISARDKLLSTALHVAVRTGHYECAEH 237

Query: 98  LMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR 146
           L+    +L       +   G T LH AV      ++R L+   A ++ +
Sbjct: 238 LIACEADL-----NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIK 281


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 61/222 (27%), Positives = 94/222 (42%), Gaps = 34/222 (15%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  +++E    V    LLD    +      G T LH+AA Y  LE A +L++  A+P+
Sbjct: 534 TPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
              +       +G T LH+A    N  +   LL + AS  A A               G 
Sbjct: 593 AAGK-------SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN-------------GY 632

Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224
            PL  AA  N  +I   L+E+GAD  A    G   +H+   + +      M +LLL  + 
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH----VDMVSLLLGRNA 688

Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266
           + +       + N  GLTP  LA  E    + + L+ +  H+
Sbjct: 689 NVN-------LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 53/185 (28%), Positives = 78/185 (42%), Gaps = 22/185 (11%)

Query: 20  PSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLL--DCTCDVRQRGA 77
           P  +  +Q  DQ +  L     K  +  P L  +   D +    LLL  D   DV  +  
Sbjct: 176 PLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS- 234

Query: 78  LGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALL 137
            G T LHIAA Y N+  A +L+  A  + F      A    T LH+A    N N+V+ LL
Sbjct: 235 -GFTPLHIAAHYGNINVATLLLNRAAAVDF-----TARNDITPLHVASKRGNANMVKLLL 288

Query: 138 TRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGN 197
            R A + A+                G  PL   A    E++V +L++  A I ++   G 
Sbjct: 289 DRGAKIDAKTRD-------------GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335

Query: 198 TVLHI 202
           + LH+
Sbjct: 336 SPLHM 340



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 63/237 (26%), Positives = 93/237 (39%), Gaps = 41/237 (17%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104
           +PL  A+K   L V   LLL  +      G  G T LH+AA YDN + AL+L++  A+P 
Sbjct: 567 TPLHVAAKYGKLEVAN-LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALL---------TRRASVSARATGTAFRRS 155
                    A  G T LHIA     +++   LL         TR+   S           
Sbjct: 626 -------AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678

Query: 156 PRNLIY-----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204
             +L+             G  PL  AA  +   +  +L+  GA + AQ  +G T LH+  
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738

Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
              N     ++ N LL +    +            G TP   A  +G+T +   L+Q
Sbjct: 739 HYGN----IKIVNFLLQHSAKVN-------AKTKNGYTPLHQAAQQGHTHIINVLLQ 784



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 55/212 (25%), Positives = 81/212 (38%), Gaps = 30/212 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A K+N + V+ +LLL     ++     G T +H+AA   ++     LM       
Sbjct: 402 TPLHIACKKNRIKVM-ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS-- 458

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR------------- 153
             P T     G+TALH+A  +    +VR L+   A V A+A                   
Sbjct: 459 --PNTTNV-RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515

Query: 154 -------RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQ 206
                   SP      G  PL  +A    E++   L++HGA +      G T LH+    
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA-- 573

Query: 207 PNKTFACQMYNLLLSYDGHGDHLQPLDLVPNH 238
             K    ++ NLLL      D      L P H
Sbjct: 574 --KYGKLEVANLLLQKSASPDAAGKSGLTPLH 603



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 29/205 (14%)

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           ++LLD    +  +   G + LH+A   D+L    +L++    +  +  T +     TALH
Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH--NVPVDDVTNDYL---TALH 372

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
           +A    +  + + LL ++A+ +A+A               G  PL  A   N  +++ LL
Sbjct: 373 VAAHCGHYKVAKVLLDKKANPNAKALN-------------GFTPLHIACKKNRIKVMELL 419

Query: 183 IEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLT 242
           ++HGA I+A    G T +H+     +     Q+ +       HG          N +G T
Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH-------HGASPN----TTNVRGET 468

Query: 243 PFKLAGVEGNTVMFQHLMQKRRHIQ 267
              +A   G   + ++L+Q    ++
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVE 493



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 51/176 (28%), Positives = 71/176 (40%), Gaps = 26/176 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           SPL  A++ + L+ + QLLL     V        TALH+AA   + + A VL++      
Sbjct: 336 SPLHMATQGDHLNCV-QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN-- 392

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATG-------TAFR------ 153
                 +A  G T LHIA     + ++  LL   AS+ A            AF       
Sbjct: 393 ---PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449

Query: 154 -------RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
                   SP      GE  L  AA     E+VR L++ GA + A+     T LHI
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 41/148 (27%), Positives = 66/148 (44%), Gaps = 22/148 (14%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G  ALH+A+   ++E    L++    +           G TALHIA +     +V+ L+T
Sbjct: 74  GLNALHLASKEGHVEVVSELLQREANV-----DAATKKGNTALHIASLAGQAEVVKVLVT 128

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
             A+V+A++               G  PL  AA  N  E+V+ L+++GA        G T
Sbjct: 129 NGANVNAQSQN-------------GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFT 175

Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHG 226
            L + + Q +     Q+ +LLL  D  G
Sbjct: 176 PLAVALQQGHD----QVVSLLLENDTKG 199



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 6/96 (6%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A++E+ ++V  ++L++    V  +  +G T LH+   Y N++    L++ + ++ 
Sbjct: 699 TPLHLAAQEDRVNVA-EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV- 756

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142
                 +   G T LH A    + +++  LL   AS
Sbjct: 757 ----NAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/184 (30%), Positives = 84/184 (45%), Gaps = 23/184 (12%)

Query: 40  QQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLM 99
           +Q    E+ L  A++     V+  LL + T D   R +  ET L +AALY  L    +++
Sbjct: 123 EQNNENETALHCAAQYGHSEVVAVLLEELT-DPTIRNSKLETPLDLAALYGRLRVVKMII 181

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARAT-GTAFRRSPRN 158
            A P L+    +C      T LH+A  N +  +V+ LL     VS +   G+A       
Sbjct: 182 SAHPNLM----SCNT-RKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE---- 232

Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 218
                      AA     ++VR+L+E G D   +DSLG TVL IL   P++  + Q+  L
Sbjct: 233 -----------AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQK-SLQIATL 280

Query: 219 LLSY 222
           L  Y
Sbjct: 281 LQEY 284



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 16/93 (17%)

Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAA 171
           C   +G TALH A +N + ++V  LL   AS +             N  YF   P+  AA
Sbjct: 54  CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVAD----------NKGYF---PIHLAA 100

Query: 172 CVNSEEIVRLLIEHG---ADIRAQDSLGNTVLH 201
                EIV++LI HG   + +  Q++   T LH
Sbjct: 101 WKGDVEIVKILIHHGPSHSRVNEQNNENETALH 133



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 34/207 (16%)

Query: 56  NDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEA- 114
           N LS+ R   ++CT       + G TALH AAL  + +  L L++      +E +T  A 
Sbjct: 42  NLLSIWRGPNVNCT------DSSGYTALHHAALNGHKDIVLKLLQ------YEASTNVAD 89

Query: 115 FAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVN 174
             G   +H+A    +V +V+ L+    S S        R + +N     E  L  AA   
Sbjct: 90  NKGYFPIHLAAWKGDVEIVKILIHHGPSHS--------RVNEQN--NENETALHCAAQYG 139

Query: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDL 234
             E+V +L+E   D   ++S   T L +  L        ++  +++S         P  +
Sbjct: 140 HSEVVAVLLEELTDPTIRNSKLETPLDLAALYGR----LRVVKMIIS-------AHPNLM 188

Query: 235 VPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
             N +  TP  LA   G+  + Q L++
Sbjct: 189 SCNTRKHTPLHLAARNGHKAVVQVLLE 215


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 38/108 (35%), Positives = 57/108 (52%), Gaps = 7/108 (6%)

Query: 52  ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111
           A++ N LS++R LLL   C V ++   G+TALH+AA  ++ + A +L+EA  +     TT
Sbjct: 181 AARYNHLSIIR-LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-----TT 234

Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159
               AGQT L  A  + N   V  LLT+   V   + G + R+    L
Sbjct: 235 IVNNAGQTPLETARYHNNPE-VALLLTKAPQVLRFSRGRSLRKKRERL 281



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 37/138 (26%), Positives = 64/138 (46%), Gaps = 18/138 (13%)

Query: 63  QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122
           +LL+    +V  +   G TALH+A    + ++  VL+ A      +       AG T LH
Sbjct: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN-----AGDTCLH 179

Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182
           +A    +++++R LLT   SV  +                G+  L  AA +N +++ ++L
Sbjct: 180 VAARYNHLSIIRLLLTAFCSVHEKNQA-------------GDTALHVAAALNHKKVAKIL 226

Query: 183 IEHGADIRAQDSLGNTVL 200
           +E GAD    ++ G T L
Sbjct: 227 LEAGADTTIVNNAGQTPL 244



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 18/124 (14%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G T LH+AA   +L    +L++A  +L  +         QTALH A V  N  ++ AL+ 
Sbjct: 42  GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD-----GDQTALHRATVVGNTEIIAALIH 96

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
                     G A  R  ++    G   L  A+     +  +LL++ GA++ A++  GNT
Sbjct: 97  E---------GCALDRQDKD----GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNT 143

Query: 199 VLHI 202
            LH+
Sbjct: 144 ALHL 147



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/207 (23%), Positives = 86/207 (41%), Gaps = 30/207 (14%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           ++ L RA+   +  ++  L+ +  C + ++   G TALH A+ +   ++A +L++A   +
Sbjct: 76  QTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134

Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165
           + +       AG TALH+A  N +    R LL   +    +                G+ 
Sbjct: 135 LAKNK-----AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-------------GDT 176

Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225
            L  AA  N   I+RLL+     +  ++  G+T LH+     +K  A     +LL     
Sbjct: 177 CLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVA----KILLEAGAD 232

Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGN 252
                    + N+ G TP + A    N
Sbjct: 233 -------TTIVNNAGQTPLETARYHNN 252


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 67/232 (28%), Positives = 100/232 (43%), Gaps = 42/232 (18%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTC-DVRQRGALGETALHIAAL--YDNLEAALVLMEAAP 103
           +PL  A++  D    R LL    C D ++R   G T LH+AA   ++N+   LV  +A P
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQERE--GWTPLHLAAQNNFENVARLLVSRQADP 487

Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFG 163
            L           G+T LH+A    +V+LV+ L ++ A + A+          RNL    
Sbjct: 488 NL-------HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ---------RNL---- 527

Query: 164 EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223
             PL  A        ++ L++ GA   A D  G   LH    +  K   C+M   LL Y 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR-GKYLICKM---LLRY- 582

Query: 224 GHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRH------IQWT 269
             G  L+    +P HQG TP  LA  +G+  +   L +   +      + WT
Sbjct: 583 --GASLE----LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/158 (26%), Positives = 68/158 (43%), Gaps = 19/158 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+ +  L ++  LL +   ++   GA+  T LH+AA +        L++   +  
Sbjct: 595 TPLHLAAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD-- 651

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166
             P   E  +G T LH+AV       V  LL   A+V AR                G  P
Sbjct: 652 --PNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHANVHARNK-------------VGWTP 695

Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204
              AA   +  I+++L+E GA +  QD +  T L + +
Sbjct: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 19/162 (11%)

Query: 41  QKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100
           Q+R   +PL  A++ N  +V R LL+    D     A G+T LH+AA + ++    +L  
Sbjct: 457 QEREGWTPLHLAAQNNFENVAR-LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515

Query: 101 AAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLI 160
              EL  +         +T LH+AV    V  ++ LL   A              P  L 
Sbjct: 516 QGAELDAQQRNL-----RTPLHLAVERGKVRAIQHLLKSGA-------------VPDALD 557

Query: 161 YFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202
             G  PL  AA      I ++L+ +GA +      G T LH+
Sbjct: 558 QSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/223 (25%), Positives = 90/223 (40%), Gaps = 34/223 (15%)

Query: 41  QKRILESPLLRASKENDLSVLRQLLLD-CTCDVRQRGALGETALHIAALYDNLEAALVLM 99
           Q+R L +PL  A +   +  ++ LL      D   +   G   LH AA         +L+
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP--LHTAAARGKYLICKMLL 580

Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159
                L   PT      G T LH+A    ++ ++  L    A++ A              
Sbjct: 581 RYGASLEL-PT----HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGA----------- 624

Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLL 219
                 PL  AA    E +V  L++ GAD  A +  G T LH+ +    ++    + NLL
Sbjct: 625 --VNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV---QRSTFLSVINLL 679

Query: 220 LSYDGHGD-HLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
              + H + H +      N  G TP  LA ++GNT + + L++
Sbjct: 680 ---EHHANVHAR------NKVGWTPAHLAALKGNTAILKVLVE 713



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 18/122 (14%)

Query: 81  TALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR 140
           T LH      ++E   +L+    ++      C+  +G T L IA  +Q  +L   LL   
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDV-----DCQTASGYTPLLIAAQDQQPDLCALLLAHG 418

Query: 141 ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200
           A  +              +   G  PL FAA    +   RLL++HGA + AQ+  G T L
Sbjct: 419 ADAN-------------RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465

Query: 201 HI 202
           H+
Sbjct: 466 HL 467



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 59/202 (29%), Positives = 76/202 (37%), Gaps = 35/202 (17%)

Query: 63  QLLLDCTCDVRQRGALGETALHIAAL--YDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120
           +LLL    DV  + A G T L IAA     +L A L+   A    V E        G   
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-------GWAP 431

Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180
           LH A  N +    R LL   A V A+                G  PL  AA  N E + R
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQERE-------------GWTPLHLAAQNNFENVAR 478

Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240
           LL+   AD    ++ G T LH+     +      +  LL S        Q  +L    + 
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGH----VSLVKLLTS--------QGAELDAQQRN 526

Query: 241 L-TPFKLAGVEGNTVMFQHLMQ 261
           L TP  LA   G     QHL++
Sbjct: 527 LRTPLHLAVERGKVRAIQHLLK 548


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 63/237 (26%), Positives = 95/237 (40%), Gaps = 43/237 (18%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL RA+   +  VL  LLL  + DV  R  L +T LH+AA       A    EA   L+
Sbjct: 76  TPLHRAAASRNEKVLG-LLLAHSADVNARDKLWQTPLHVAA----ANRATKCAEALAPLL 130

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYF---- 162
                 +  +G++ALH AV + ++  V  LL + AS++         R P +   F    
Sbjct: 131 SSLNVADR-SGRSALHHAVHSGHLETVNLLLNKGASLN---VCDKKERQPLHWAAFLGHL 186

Query: 163 -------------------GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203
                              G   L  AA     E+V+ L+  GA+I   ++ GNT LHI 
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246

Query: 204 ILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLM 260
                   A ++ N   + +            PN +G TP  +A V  N  +   L+
Sbjct: 247 CYLGQDAVAIELVNAGANVN-----------QPNDKGFTPLHVAAVSTNGALCLELL 292



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 55/216 (25%), Positives = 91/216 (42%), Gaps = 31/216 (14%)

Query: 47  SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106
           +PL  A+   + ++  +LL++   DV  +   G++ LH+AA++     + +L++   E+ 
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI- 332

Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRSP 156
                C    G T LH+A    +  L+  L+T  A  + R          A    F    
Sbjct: 333 ----DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388

Query: 157 RNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMY 216
           R L+  G+   S  + +++E +    +  G DI   D+LG T LH      N     +  
Sbjct: 389 RKLLSSGQ-LYSIVSSLSNEHV----LSAGFDINTPDNLGRTCLHAAASGGN----VECL 439

Query: 217 NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
           NLLLS    G  L+  D      G TP   A   G+
Sbjct: 440 NLLLS---SGADLRRRDKF----GRTPLHYAAANGS 468



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 42/139 (30%), Positives = 61/139 (43%), Gaps = 19/139 (13%)

Query: 65  LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124
           LL    ++ +  A G TALHIA        A+ L+ A    V +P       G T LH+A
Sbjct: 225 LLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN-VNQPND----KGFTPLHVA 279

Query: 125 VVNQNVNLVRALLTRR-ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLI 183
            V+ N  L   LL    A V+ ++               G+ PL  AA        ++LI
Sbjct: 280 AVSTNGALCLELLVNNGADVNYQSKE-------------GKSPLHMAAIHGRFTRSQILI 326

Query: 184 EHGADIRAQDSLGNTVLHI 202
           ++G++I   D  GNT LH+
Sbjct: 327 QNGSEIDCADKFGNTPLHV 345



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 13/85 (15%)

Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177
           +T LH A    +V +++ LL   A+V+A+ T                 PL  AA   +E+
Sbjct: 42  RTPLHAAAYVGDVPILQLLLMSGANVNAKDT-------------LWLTPLHRAAASRNEK 88

Query: 178 IVRLLIEHGADIRAQDSLGNTVLHI 202
           ++ LL+ H AD+ A+D L  T LH+
Sbjct: 89  VLGLLLAHSADVNARDKLWQTPLHV 113



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 63/270 (23%), Positives = 93/270 (34%), Gaps = 65/270 (24%)

Query: 46  ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105
           E   L+ S+  +     + LLD   D   R   G TA+H AA Y N +   +L+E +   
Sbjct: 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576

Query: 106 VFEPTT---------------CEAF---------------AGQTALHIAVVNQNVNLVRA 135
           + +  +               CEA                 G+TAL +A    +   V  
Sbjct: 577 LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEV 636

Query: 136 LLTRRASVSAR-----------ATGTAFRRSPRNLI-------------YFGEHPLSFAA 171
           L    AS   +           A  +    S   LI              +G+ PL  A 
Sbjct: 637 LTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAI 696

Query: 172 CVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQP 231
                + V LL+E G+   A D  G T LH    +   T        LL +D        
Sbjct: 697 MNGHVDCVHLLLEKGSTADAADLRGRTALH----RGAVTGCEDCLAALLDHDA------- 745

Query: 232 LDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
             L  + +G TP  LA   G+T + + L+Q
Sbjct: 746 FVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 44/170 (25%), Positives = 60/170 (35%), Gaps = 41/170 (24%)

Query: 72   VRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVN 131
            V  R A G T LH AA  DN+    +L++   E+     T     G+TAL  A  N    
Sbjct: 851  VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-----GRTALMTAAENGQTA 905

Query: 132  LVRALLTRRASVSARATGTAFRRSPRNLIYFG---------------------------- 163
             V  LL R      +A  T    +    ++                              
Sbjct: 906  AVEFLLYR-----GKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA 960

Query: 164  -EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212
             + PL  AA      +V+ L+ HGA + A D  G+T    L   PNK  A
Sbjct: 961  LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT--PALACAPNKDVA 1008



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 26/165 (15%)

Query: 32  HLDKLHML----QQKRILE-------SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGE 80
           H D LH+L    ++  I +       +PL+ A     +  +  LLL+           G 
Sbjct: 664 HTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH-LLLEKGSTADAADLRGR 722

Query: 81  TALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR 140
           TALH  A+    +    L++    ++     C  F G+T +H+A    +  ++R LL   
Sbjct: 723 TALHRGAVTGCEDCLAALLDHDAFVL-----CRDFKGRTPIHLASACGHTAVLRTLLQAA 777

Query: 141 ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH 185
            S      G         + Y G  P+ +A+    E+ + LL+EH
Sbjct: 778 LSTDPLDAG---------VDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 55/237 (23%), Positives = 89/237 (37%), Gaps = 54/237 (22%)

Query: 64  LLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHI 123
           LLL    D+R+R   G T LH AA   + + A+ L+ A   +      C+   G + LH 
Sbjct: 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV--NEADCK---GCSPLHY 495

Query: 124 AVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLI 183
           A  +           RRA     ++  A            + PL  +    +   +  L+
Sbjct: 496 AAASDTY--------RRAEPHTPSSHDAEE----------DEPLKESRRKEAFFCLEFLL 537

Query: 184 EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL------------------LLSYDGH 225
           ++GAD   +D  G T +H      N+     +  +                  L +Y+GH
Sbjct: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597

Query: 226 GDHLQPLDL------VPNHQGLTPFKLAGVEGNT----VMFQH---LMQKRRHIQWT 269
            + L+ L        V +H+G T   LA   G+T    V+  H    + K R  +WT
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWT 654



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 40/157 (25%), Positives = 67/157 (42%), Gaps = 20/157 (12%)

Query: 47  SPLLRASKENDLSVLRQLLLDC-TCDVRQRGA--LGETALHIAALYDNLEAALVLMEAAP 103
           +P+  AS     +VLR LL    + D    G    G + +H A+   + +   +L+E +P
Sbjct: 756 TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815

Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFG 163
               E          T LH AV+N   +    LL    ++ A+   +   +        G
Sbjct: 816 FSYLEGNPF------TPLHCAVINNQDSTTEMLL---GALGAKIVNSRDAK--------G 858

Query: 164 EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200
             PL  AA  ++   +R+L++H A++ A D  G T L
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 23/143 (16%)

Query: 64   LLLDCTCDVRQRGA----LGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQT 119
            ++ D  C   Q GA     GETALH+AA Y   +AA  L++A  +     T  +  +G+T
Sbjct: 1820 IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGAD-----TNAQDHSGRT 1874

Query: 120  ALHIAVVNQNVNLVRALLTRRAS-VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEI 178
             LH AV      + + L+  R++ + AR                G   L  AA +  E +
Sbjct: 1875 PLHTAVTADAQGVFQILIRNRSTDLDARMAD-------------GSTALILAARLAVEGM 1921

Query: 179  VRLLIEHGADIRAQDSLGNTVLH 201
            V  LI   AD+ A D LG + LH
Sbjct: 1922 VEELIASHADVNAVDELGKSALH 1944



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 22/151 (14%)

Query: 47   SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAA--LYDNLEAALVLMEAAPE 104
            +PL  A   +   V + L+ + + D+  R A G TAL +AA    + +   L+   A   
Sbjct: 1874 TPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVN 1933

Query: 105  LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164
             V E        G++ALH A    NV    ALL   A+   + +               E
Sbjct: 1934 AVDE-------LGKSALHWAAAVNNVEATLALLKNGANKDMQDSKE-------------E 1973

Query: 165  HPLSFAACVNSEEIVRLLIEHGADIRAQDSL 195
             PL  AA   S E  +LL++H A+    D L
Sbjct: 1974 TPLFLAAREGSYEAAKLLLDHFANREITDHL 2004



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 12/76 (15%)

Query: 129  NVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGAD 188
            + +++  L+ + A + AR   T            GE  L  AA     +  + L++ GAD
Sbjct: 1817 SASIISDLICQGAQLGARTDRT------------GETALHLAARYARADAAKRLLDAGAD 1864

Query: 189  IRAQDSLGNTVLHILI 204
              AQD  G T LH  +
Sbjct: 1865 TNAQDHSGRTPLHTAV 1880


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 30/180 (16%)

Query: 74   QRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLV 133
            Q    GETALH+AA Y   +AA  L+EA+ +   +        G+T LH AV      + 
Sbjct: 1923 QTDRTGETALHLAARYSRSDAAKRLLEASADANIQDN-----MGRTPLHAAVSADAQGVF 1977

Query: 134  RALLTRRAS-VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192
            + L+  RA+ + AR             ++ G  PL  AA +  E ++  LI   AD+ A 
Sbjct: 1978 QILIRNRATDLDAR-------------MHDGTTPLILAARLAVEGMLEDLINSHADVNAV 2024

Query: 193  DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252
            D LG + LH      N   A     ++L  +G    +Q      N++  TP  LA  EG+
Sbjct: 2025 DDLGKSALHWAAAVNNVDAA-----VVLLKNGANKDMQ------NNREETPLFLAAREGS 2073



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 19/54 (35%), Positives = 34/54 (62%), Gaps = 1/54 (1%)

Query: 47   SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100
            +PL+ A++     +L  L+ +   DV     LG++ALH AA  +N++AA+VL++
Sbjct: 1997 TPLILAARLAVEGMLEDLI-NSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLK 2049


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 36/124 (29%), Positives = 59/124 (47%), Gaps = 18/124 (14%)

Query: 79  GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138
           G TALH+A   DN E    L+ +  ++         + G TALHIA +  ++     LL 
Sbjct: 101 GFTALHLAVYKDNAELITSLLHSGADI-----QQVGYGGLTALHIATIAGHLEAADVLLQ 155

Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198
             A+V+ +           + ++F   PL  AA    E++ RLL++ GAD+     +G+ 
Sbjct: 156 HGANVNIQ-----------DAVFFT--PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDR 202

Query: 199 VLHI 202
            LH+
Sbjct: 203 PLHL 206



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 60/207 (28%), Positives = 84/207 (40%), Gaps = 45/207 (21%)

Query: 65  LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124
           LL    D++Q G  G TALHIA +  +LEAA VL++    +  +          T LHIA
Sbjct: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF-----FTPLHIA 174

Query: 125 VVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIE 184
               +  + R LL   A V+                  G+ PL  A+      I +LL+E
Sbjct: 175 AYYGHEQVTRLLLKFGADVNVSGE-------------VGDRPLHLASAKGFLNIAKLLME 221

Query: 185 HG--ADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD---HLQPLDL----- 234
            G  AD+ AQD+  +  LH           C  +       GH D   +L   DL     
Sbjct: 222 EGSKADVNAQDNEDHVPLHF----------CSRF-------GHHDIVKYLLQSDLEVQPH 264

Query: 235 VPNHQGLTPFKLAGVEGNTVMFQHLMQ 261
           V N  G TP  LA   G   + + ++Q
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVAKEIIQ 291



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 30/142 (21%), Positives = 59/142 (41%), Gaps = 20/142 (14%)

Query: 64  LLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHI 123
           +LL    +V  + A+  T LHIAA Y + +   +L++   ++           G   LH+
Sbjct: 152 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV-----NVSGEVGDRPLHL 206

Query: 124 AVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH-PLSFAACVNSEEIVRLL 182
           A     +N+ + L+   +     A                +H PL F +     +IV+ L
Sbjct: 207 ASAKGFLNIAKLLMEEGSKADVNAQDNE------------DHVPLHFCSRFGHHDIVKYL 254

Query: 183 IEHGADIRAQ--DSLGNTVLHI 202
           ++   +++    +  G+T LH+
Sbjct: 255 LQSDLEVQPHVVNIYGDTPLHL 276


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,180,811
Number of Sequences: 37866
Number of extensions: 1116973
Number of successful extensions: 5984
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 3993
Number of HSP's gapped (non-prelim): 1215
length of query: 729
length of database: 18,247,518
effective HSP length: 110
effective length of query: 619
effective length of database: 14,082,258
effective search space: 8716917702
effective search space used: 8716917702
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.