BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|17505200 transient receptor potential cation channel, subfamily V, member 5 [Homo sapiens] (729 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|17505200 transient receptor potential cation channel, subfami... 1464 0.0 gi|21314682 transient receptor potential cation channel, subfami... 1071 0.0 gi|22547184 transient receptor potential cation channel, subfami... 266 4e-71 gi|74315354 transient receptor potential cation channel, subfami... 240 3e-63 gi|74315352 transient receptor potential cation channel, subfami... 240 3e-63 gi|74315350 transient receptor potential cation channel, subfami... 240 3e-63 gi|74315348 transient receptor potential cation channel, subfami... 240 3e-63 gi|21735483 transient receptor potential cation channel, subfami... 236 6e-62 gi|22547180 transient receptor potential cation channel, subfami... 206 5e-53 gi|20127551 transient receptor potential cation channel, subfami... 204 3e-52 gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 65 2e-10 gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 65 2e-10 gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 65 2e-10 gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 65 2e-10 gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 65 2e-10 gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 64 5e-10 gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 64 5e-10 gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 64 5e-10 gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 60 9e-09 gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 59 2e-08 gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 59 2e-08 gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 58 4e-08 gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 57 5e-08 gi|50511945 cajalin 2 isoform a [Homo sapiens] 56 1e-07 gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 54 4e-07 gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 54 5e-07 gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 54 5e-07 gi|134244285 Notch homolog 3 [Homo sapiens] 54 7e-07 gi|148833508 notch1 preproprotein [Homo sapiens] 53 9e-07 gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 53 9e-07 >gi|17505200 transient receptor potential cation channel, subfamily V, member 5 [Homo sapiens] Length = 729 Score = 1464 bits (3790), Expect = 0.0 Identities = 729/729 (100%), Positives = 729/729 (100%) Query: 1 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV Sbjct: 1 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60 Query: 61 LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120 LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA Sbjct: 61 LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120 Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR Sbjct: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300 Query: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT Sbjct: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360 Query: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI Sbjct: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420 Query: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI Sbjct: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540 Query: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT Sbjct: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 Query: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ Sbjct: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660 Query: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE 720 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE Sbjct: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE 720 Query: 721 GDGEEVYHF 729 GDGEEVYHF Sbjct: 721 GDGEEVYHF 729 >gi|21314682 transient receptor potential cation channel, subfamily V, member 6 [Homo sapiens] Length = 725 Score = 1072 bits (2771), Expect = 0.0 Identities = 547/729 (75%), Positives = 607/729 (83%), Gaps = 15/729 (2%) Query: 1 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV 60 MG LPK +G L + R + W Q D+ ++LQQKRI ESPLL A+K+ND+ Sbjct: 1 MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQA 60 Query: 61 LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120 L +LL C V QRGA+GETALHIAALYDNLEAA+VLMEAAPELVFEP T E + GQTA Sbjct: 61 LNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120 Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180 LHIAVVNQN+NLVRALL RRASVSARATGTAFRRSP NLIYFGEHPLSFAACVNSEEIVR Sbjct: 121 LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD HGDHLQPLDLVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD 300 LTPFKLAGVEGNTVMFQHLMQKR+H QWTYGPLTS LYDLTEIDS G+E S LEL++++ Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTK 300 Query: 301 KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT 360 KREARQIL+QTPVKELVS KW +YGRPYFC+L A+YLLY+ICFT CC+YRPLK R NRT Sbjct: 301 KREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT 360 Query: 361 HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI 420 RD T+LQQKLLQEAY T +D IRLVGELV+++GA+IILL+E+PDIFR+G +R+FG+TI Sbjct: 361 SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI 420 Query: 421 LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI 480 LGGPFHV+IITYA +VLVTMVMRL + +GEVVPMSFALVLGWC+VMYF RGFQMLGPFTI Sbjct: 421 LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV 540 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDP LG FYDYPMALF+TFELFLT+ Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTI 540 Query: 541 IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 ID PANY+VDLPFM+SI AFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQ+VAT Sbjct: 541 IDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT 600 Query: 601 TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ 660 TVMLERKLPRCLWPRSGICG E+GLGDRWFLRVE+ D N R+ RY + F ED Sbjct: 601 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLD 660 Query: 661 EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTL-----GHLNLG 715 + EK E G L+LP S+SR+ S+SS++ WE LRQ TL G +N G Sbjct: 661 KDSVEK----LELGCPFSPHLSLPMPSVSRSTSRSSAN--WERLRQGTLRRDLRGIINRG 714 Query: 716 LNLSEGDGE 724 L DGE Sbjct: 715 LE----DGE 719 >gi|22547184 transient receptor potential cation channel, subfamily V, member 4 isoform a [Homo sapiens] Length = 871 Score = 266 bits (681), Expect = 4e-71 Identities = 192/581 (33%), Positives = 286/581 (49%), Gaps = 68/581 (11%) Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR-RSPRNLIYF 162 E + P + GQTALHIA+ + + V L+ + A V A+A G F+ + YF Sbjct: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284 Query: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214 GE PLS AAC N IV L E+ AD+R QDS GNTVLH L+ + N F + Sbjct: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Query: 215 MYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR------RHIQ- 267 MY+LLL L+ V N+ GL+P +A G +FQH++++ RH+ Sbjct: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSR 404 Query: 268 ----WTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREAR-QILEQTPVKELVSFKWN 322 W YGP+ S LYDL+ +D+ GEE S LE++V + K E R ++L P+ EL+ KW Sbjct: 405 KFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWR 464 Query: 323 KYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETRED 382 K+G F I YL M+ FT Y+PL+ G + Y T D Sbjct: 465 KFGAVSFYINVVSYLCAMVIFTLTAYYQPLE---GTPPYP--------------YRTTVD 507 Query: 383 IIRLVGELVSIVGAVIILLLEIPDIFRV---GASRYFGKTILGGPFHVIIITYASLVLVT 439 +RL GE++++ V+ I D+F G + F + G F ++ Y+ LV+V+ Sbjct: 508 YLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVS 563 Query: 440 MVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAV 499 + L + M FALVLGW + +YFTRG ++ G ++IMIQK++F DL RF + + Sbjct: 564 AALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLL 623 Query: 500 VILGFASAFYIIFQ--------TEDPT--------SLGQFYDYPMALFTTFELFLTVIDA 543 ++G+ASA + ED T S + L F+L + + D Sbjct: 624 FMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDL 683 Query: 544 PANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVM 603 P +F I+ + I+ +L+LN+ IA+MG+T +V++E +W+ Q T + Sbjct: 684 EMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 743 Query: 604 LERKLPRCLWP--RSG----ICGCEFGLGD-RWFLRVENHN 637 +ER P L RSG + G D RW RV+ N Sbjct: 744 IERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVN 784 >gi|74315354 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 240 bits (613), Expect = 3e-63 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%) Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158 ++ ELV T + GQTALHIA+ +N+ LV L+ A V A A G F+++ R Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317 R+ +W YGP+ S LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377 KW+++ + F +Y LYMI FT YRP+ L Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466 Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436 E D R+ GE++S++G V I + S KT+ + ++ SL + Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523 Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496 L T+V+ ++ V M F+L LGW +++Y+TRGFQ +G + +MI+KMI DL RF ++ Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583 Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541 V + GF++A + + P Y T ELF I Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643 Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598 D + D +F I+ A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703 Query: 599 ATTVMLERKLPRCL 612 T + E+ +C+ Sbjct: 704 ITILDTEKSFLKCM 717 >gi|74315352 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 240 bits (613), Expect = 3e-63 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%) Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158 ++ ELV T + GQTALHIA+ +N+ LV L+ A V A A G F+++ R Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317 R+ +W YGP+ S LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377 KW+++ + F +Y LYMI FT YRP+ L Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466 Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436 E D R+ GE++S++G V I + S KT+ + ++ SL + Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523 Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496 L T+V+ ++ V M F+L LGW +++Y+TRGFQ +G + +MI+KMI DL RF ++ Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583 Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541 V + GF++A + + P Y T ELF I Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643 Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598 D + D +F I+ A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703 Query: 599 ATTVMLERKLPRCL 612 T + E+ +C+ Sbjct: 704 ITILDTEKSFLKCM 717 >gi|74315350 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 240 bits (613), Expect = 3e-63 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%) Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158 ++ ELV T + GQTALHIA+ +N+ LV L+ A V A A G F+++ R Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317 R+ +W YGP+ S LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377 KW+++ + F +Y LYMI FT YRP+ L Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466 Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436 E D R+ GE++S++G V I + S KT+ + ++ SL + Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523 Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496 L T+V+ ++ V M F+L LGW +++Y+TRGFQ +G + +MI+KMI DL RF ++ Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583 Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541 V + GF++A + + P Y T ELF I Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643 Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598 D + D +F I+ A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703 Query: 599 ATTVMLERKLPRCL 612 T + E+ +C+ Sbjct: 704 ITILDTEKSFLKCM 717 >gi|74315348 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 240 bits (613), Expect = 3e-63 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%) Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158 ++ ELV T + GQTALHIA+ +N+ LV L+ A V A A G F+++ R Sbjct: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 Query: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 Query: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317 R+ +W YGP+ S LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ Sbjct: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 Query: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377 KW+++ + F +Y LYMI FT YRP+ L Sbjct: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466 Query: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436 E D R+ GE++S++G V I + S KT+ + ++ SL + Sbjct: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523 Query: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496 L T+V+ ++ V M F+L LGW +++Y+TRGFQ +G + +MI+KMI DL RF ++ Sbjct: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583 Query: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541 V + GF++A + + P Y T ELF I Sbjct: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643 Query: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598 D + D +F I+ A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q Sbjct: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703 Query: 599 ATTVMLERKLPRCL 612 T + E+ +C+ Sbjct: 704 ITILDTEKSFLKCM 717 >gi|21735483 transient receptor potential cation channel, subfamily V, member 3 [Homo sapiens] Length = 790 Score = 236 bits (602), Expect = 6e-62 Identities = 184/633 (29%), Positives = 307/633 (48%), Gaps = 75/633 (11%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQR---------------GA 77 L K ++KR L+ + A E + L +LL++ R+R Sbjct: 107 LAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASD 166 Query: 78 LGETALHIAALYDN---LEAALVLMEAAPE------LVFEPTTCEAFAGQTALHIAVVNQ 128 G+T L A L N E +L+ A E + T EA+ GQTAL+IA+ + Sbjct: 167 TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERR 226 Query: 129 NVNLVRALLTRRASVSARATGTAFR-RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG- 186 ++ L+ A V+A A G F + YFGE PL+ AAC N EIV+LL+EH Sbjct: 227 QGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQ 286 Query: 187 ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGL 241 DI ++DS GN +LH L+ + F +MY+++L G+ + L+ N+ GL Sbjct: 287 TDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE----LETTRNNDGL 342 Query: 242 TPFKLAGVEGNTVMFQHLMQK-----------RRHIQWTYGPLTSILYDLTEIDSWGEEL 290 TP +LA G + ++++ + R+ W YGP++S LYDLT +D+ + Sbjct: 343 TPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDN- 401 Query: 291 SFLELVVSSDKREAR-QILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVY 349 S LE+ V + + R ++L P+ L+ KW K+ + F + Y Y I T Y Sbjct: 402 SVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY 461 Query: 350 RPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFR 409 RP R+ + L A + ++L+G + ++ A+ I + E IF Sbjct: 462 RP-----------REEEAIPHPL---ALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFL 507 Query: 410 VGASRYFGKTILGGP-FHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYF 468 + S ++IL FH + A LV++++ + L + + A+ LGW +++Y+ Sbjct: 508 LRPSDL--QSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY 565 Query: 469 TRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ-----TEDPTSLGQF 523 TRGFQ +G +++MIQK+I D+++F ++ V +LGF A + + +D +S G F Sbjct: 566 TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSF 625 Query: 524 YDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHW 583 D A+ F+L + + D + P +F + + I+ +L+LN+ IA+MG+T Sbjct: 626 SD---AVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVE 682 Query: 584 RVAQERDELWRAQVVATTVMLERKLPRCLWPRS 616 V++E + +WR Q T + E+ LP W RS Sbjct: 683 NVSKESERIWRLQRARTILEFEKMLPE--WLRS 713 >gi|22547180 transient receptor potential cation channel, subfamily V, member 4 isoform b [Homo sapiens] Length = 811 Score = 206 bits (525), Expect = 5e-53 Identities = 169/569 (29%), Positives = 250/569 (43%), Gaps = 104/569 (18%) Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR-RSPRNLIYF 162 E + P + GQTALHIA+ + + V L+ + A V A+A G F+ + YF Sbjct: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284 Query: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214 GE PLS AAC N IV L E+ AD+R QDS GNTVLH L+ + N F + Sbjct: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Query: 215 MYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLT 274 MY+LLL L+ V N+ GL+P +A G RH Sbjct: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKI--------GNRH--------- 387 Query: 275 SILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAA 334 ++L P+ EL+ KW K+G F I Sbjct: 388 -------------------------------EMLAVEPINELLRDKWRKFGAVSFYINVV 416 Query: 335 LYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIV 394 YL M+ FT Y+PL+ G + Y T D +RL GE++++ Sbjct: 417 SYLCAMVIFTLTAYYQPLE---GTPPYP--------------YRTTVDYLRLAGEVITLF 459 Query: 395 GAVIILLLEIPDIFRV---GASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEV 451 V+ I D+F G + F + G F ++ Y+ LV+V+ + L + Sbjct: 460 TGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVSAALYLAGIEAYL 515 Query: 452 VPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYII 511 M FALVLGW + +YFTRG ++ G ++IMIQK++F DL RF + + ++G+ASA + Sbjct: 516 AVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSL 575 Query: 512 FQ--------TEDPT--------SLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMF 555 ED T S + L F+L + + D P +F Sbjct: 576 LNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF 635 Query: 556 SIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWP- 614 I+ + I+ +L+LN+ IA+MG+T +V++E +W+ Q T + +ER P L Sbjct: 636 IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKA 695 Query: 615 -RSG----ICGCEFGLGD-RWFLRVENHN 637 RSG + G D RW RV+ N Sbjct: 696 FRSGEMVTVGKSSDGTPDRRWCFRVDEVN 724 >gi|20127551 transient receptor potential cation channel, subfamily V, member 2 [Homo sapiens] Length = 764 Score = 204 bits (518), Expect = 3e-52 Identities = 178/621 (28%), Positives = 287/621 (46%), Gaps = 82/621 (13%) Query: 76 GALGETALHIAALY--DNLEAALVLM------EAAPE-LVFEPTTCEAFAGQTALHIAVV 126 G+ G+T L A L D + A ++ + P+ LV T + + G +ALHIA+ Sbjct: 113 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 172 Query: 127 NQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG 186 +++ V+ L+ A+V ARA G F++ YFGE PLS AAC ++V L+E+ Sbjct: 173 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 232 Query: 187 ---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNH 238 A ++A DS GNTVLH L++ N MY+ LL L+ + N Sbjct: 233 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 292 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQK---------RRHIQWTYGPLTSILYDLTEIDSWGEE 289 Q LTP KLA EG +F+H++Q+ R+ +W YGP+ LYDL +DS EE Sbjct: 293 QDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSC-EE 351 Query: 290 LSFLELVV---SSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTC 346 S LE++ S R +LE P+ +L+ KW+ P F + L+YM FT Sbjct: 352 NSVLEIIAFHCKSPHRHRMVVLE--PLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAV 408 Query: 347 CVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPD 406 ++P T+ +Q E ++ L G ++ ++G + +L+ ++ Sbjct: 409 AYHQP--------------TLKKQAAPHLKAEVGNSML-LTGHILILLGGIYLLVGQLWY 453 Query: 407 IFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVM 466 +R + + + F ++ + A L +V+ V+ + + ALVLGW +++ Sbjct: 454 FWRRHV--FIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLL 511 Query: 467 YFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ----TEDPT---- 518 Y+TRGFQ G +++MIQK+I DL+RF + V + GFA A + Q E PT Sbjct: 512 YYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNA 571 Query: 519 -----------SLGQFYDYPMALFTTFELF-LTVIDAPANYDVDLPF--MFSIVNFAFAI 564 G Y L + ELF T+ + L F M ++ A+ + Sbjct: 572 TESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVL 631 Query: 565 IATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFG 624 + +L+LN+ IA+M +T VA + +W+ Q + + +E C + G Sbjct: 632 LTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWC--RKKQRAGVMLT 689 Query: 625 LG--------DRWFLRVENHN 637 +G +RW RVE N Sbjct: 690 VGTKPDGSPDERWCFRVEEVN 710 >gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] Length = 1897 Score = 65.1 bits (157), Expect = 2e-10 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA Y + A +L+E G T LH+AV + N+++V+ LL Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 R SP + + G PL AA N E+ R L+++G A+ G T Sbjct: 624 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 670 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254 LH+ + + +M LLLS +G+ + N GLTP L EG+ V Sbjct: 671 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 719 Query: 255 MFQHLMQKRRHIQWTYGPL 273 + +H + + Y PL Sbjct: 720 LIKHGVMVDATTRMGYTPL 738 Score = 60.1 bits (144), Expect = 7e-09 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%) Query: 48 PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107 P L + ND + +LL + G T LHIAA Y+NL A +L+ + F Sbjct: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P G T LHIA NV +VR LL R A + + PL Sbjct: 268 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 309 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227 AA I +L++HGA I+A+ G + +H+ + LLL YD D Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 365 Query: 228 HLQPLDLVPNH 238 + L P H Sbjct: 366 DITLDHLTPLH 376 Score = 49.3 bits (116), Expect = 1e-05 Identities = 62/279 (22%), Positives = 106/279 (37%), Gaps = 70/279 (25%) Query: 40 QQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLM 99 ++K + LRA++ +L L + D+ G LH+A+ +++ + L+ Sbjct: 40 KKKADAATSFLRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELL 98 Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159 E++ E TT + G TALHIA + +VR L+ A+V+A++ Sbjct: 99 HK--EIILETTTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK---------- 143 Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN-- 217 G PL AA N E+V+ L+E+GA+ G T L + + Q ++ + N Sbjct: 144 ---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200 Query: 218 -----------------------LLLSYDGHGDHLQPLDLVPNH---------------- 238 +LL D + D L P H Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260 Query: 239 ----------QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267 G+TP +A GN +M + L+ + I+ Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299 Score = 49.3 bits (116), Expect = 1e-05 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A ++ +V+ L+ + +G + ALHIAA D+ A VL++ P Sbjct: 179 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 230 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P G T LHIA +N+N+ + LL R ASV+ +P+N G P Sbjct: 231 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 275 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A+ + +VRLL++ GA I + T LH Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 310 Score = 45.8 bits (107), Expect = 1e-04 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92 LD+ ++ K E L + N + ++LLD ++ + G + +H+AA D+L Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 351 Query: 93 EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152 + +L++ E+ + T + T LH+A + + + LL + A ++RA Sbjct: 352 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 403 Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 G PL A N ++ LL++ GA I A G T LH+ Sbjct: 404 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 443 Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 S+ GH ++ L V N + TP +A G+T + ++L+Q + + Sbjct: 444 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496 Score = 45.1 bits (105), Expect = 2e-04 Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 23/193 (11%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A N+L +++ LLL G T LHIAA + +E A L++ Sbjct: 604 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 660 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 E+ G T LH+A + +V LL+++A+ G +S G P Sbjct: 661 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN------GNLGNKS-------GLTP 704 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226 L A + +LI+HG + A +G T LH+ N ++ LL + Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN----IKLVKFLLQHQADV 760 Query: 227 DHLQPLDLVPNHQ 239 + L P HQ Sbjct: 761 NAKTKLGYSPLHQ 773 Score = 44.3 bits (103), Expect = 4e-04 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LLL + G T LH+A+ +L L++ A+P Sbjct: 406 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +T LH+A + + + LL +A V+A+A + Sbjct: 465 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 504 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA + +V+LL+E+ A+ + G+T LHI Sbjct: 505 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542 Score = 42.7 bits (99), Expect = 0.001 Identities = 46/156 (29%), Positives = 70/156 (44%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A++E ++ LLL + G T LH+ A ++ A VL++ ++ Sbjct: 670 TPLHLAAQEGHAEMVA-LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--VM 726 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 + TT G T LH+A N+ LV+ LL +A V+A+ G P Sbjct: 727 VDATTR---MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK-------------LGYSP 770 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L AA +IV LL+++GA S G T L I Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 806 Score = 37.7 bits (86), Expect = 0.038 Identities = 44/188 (23%), Positives = 75/188 (39%), Gaps = 29/188 (15%) Query: 73 RQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132 R++ A T+ AA NL+ AL + ++ TC G LH+A +V + Sbjct: 39 RKKKADAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKM 93 Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192 V LL + + G L AA +E+VR L+ +GA++ AQ Sbjct: 94 VVELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQ 140 Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 G T L++ + + ++ LL + + V G TP +A +G+ Sbjct: 141 SQKGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGH 189 Query: 253 TVMFQHLM 260 + HL+ Sbjct: 190 ENVVAHLI 197 >gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] Length = 1881 Score = 65.1 bits (157), Expect = 2e-10 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA Y + A +L+E G T LH+AV + N+++V+ LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 R SP + + G PL AA N E+ R L+++G A+ G T Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254 LH+ + + +M LLLS +G+ + N GLTP L EG+ V Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686 Query: 255 MFQHLMQKRRHIQWTYGPL 273 + +H + + Y PL Sbjct: 687 LIKHGVMVDATTRMGYTPL 705 Score = 60.1 bits (144), Expect = 7e-09 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%) Query: 48 PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107 P L + ND + +LL + G T LHIAA Y+NL A +L+ + F Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P G T LHIA NV +VR LL R A + + PL Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227 AA I +L++HGA I+A+ G + +H+ + LLL YD D Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332 Query: 228 HLQPLDLVPNH 238 + L P H Sbjct: 333 DITLDHLTPLH 343 Score = 49.3 bits (116), Expect = 1e-05 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A ++ +V+ L+ + +G + ALHIAA D+ A VL++ P Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P G T LHIA +N+N+ + LL R ASV+ +P+N G P Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A+ + +VRLL++ GA I + T LH Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277 Score = 48.9 bits (115), Expect = 2e-05 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L L + D+ G LH+A+ +++ + L+ E++ E Sbjct: 17 LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73 Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169 TT + G TALHIA + +VR L+ A+V+A++ G PL Sbjct: 74 TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117 Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217 AA N E+V+ L+E+GA+ G T L + + Q ++ + N Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177 Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238 +LL D + D L P H Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267 G+TP +A GN +M + L+ + I+ Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A N+L +++ LLL G T LHIAA + +E A L++ Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161 E+ G T LH+A + +V LL+++A+ + G +P +L+ Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681 Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 G PL A+ + ++V+ L++H AD+ A+ LG + LH Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741 Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Q + + N + D PL + ++ + V + F + K Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801 Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319 R ++ + D++E + GEEL + +++R++R + E+ KEL+ F Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846 Score = 45.8 bits (107), Expect = 1e-04 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92 LD+ ++ K E L + N + ++LLD ++ + G + +H+AA D+L Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318 Query: 93 EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152 + +L++ E+ + T + T LH+A + + + LL + A ++RA Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370 Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 G PL A N ++ LL++ GA I A G T LH+ Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410 Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 S+ GH ++ L V N + TP +A G+T + ++L+Q + + Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463 Score = 44.3 bits (103), Expect = 4e-04 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LLL + G T LH+A+ +L L++ A+P Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +T LH+A + + + LL +A V+A+A + Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA + +V+LL+E+ A+ + G+T LHI Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509 Score = 36.6 bits (83), Expect = 0.085 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%) Query: 75 RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134 R A T+ AA NL+ AL + ++ TC G LH+A +V +V Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62 Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194 LL + + G L AA +E+VR L+ +GA++ AQ Sbjct: 63 ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109 Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254 G T L++ + + ++ LL + + V G TP +A +G+ Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158 Query: 255 MFQHLM 260 + HL+ Sbjct: 159 VVAHLI 164 >gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] Length = 1880 Score = 65.1 bits (157), Expect = 2e-10 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA Y + A +L+E G T LH+AV + N+++V+ LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 R SP + + G PL AA N E+ R L+++G A+ G T Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254 LH+ + + +M LLLS +G+ + N GLTP L EG+ V Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686 Query: 255 MFQHLMQKRRHIQWTYGPL 273 + +H + + Y PL Sbjct: 687 LIKHGVMVDATTRMGYTPL 705 Score = 60.1 bits (144), Expect = 7e-09 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%) Query: 48 PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107 P L + ND + +LL + G T LHIAA Y+NL A +L+ + F Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P G T LHIA NV +VR LL R A + + PL Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227 AA I +L++HGA I+A+ G + +H+ + LLL YD D Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332 Query: 228 HLQPLDLVPNH 238 + L P H Sbjct: 333 DITLDHLTPLH 343 Score = 49.3 bits (116), Expect = 1e-05 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A ++ +V+ L+ + +G + ALHIAA D+ A VL++ P Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P G T LHIA +N+N+ + LL R ASV+ +P+N G P Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A+ + +VRLL++ GA I + T LH Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277 Score = 48.9 bits (115), Expect = 2e-05 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L L + D+ G LH+A+ +++ + L+ E++ E Sbjct: 17 LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73 Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169 TT + G TALHIA + +VR L+ A+V+A++ G PL Sbjct: 74 TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117 Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217 AA N E+V+ L+E+GA+ G T L + + Q ++ + N Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177 Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238 +LL D + D L P H Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267 G+TP +A GN +M + L+ + I+ Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A N+L +++ LLL G T LHIAA + +E A L++ Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161 E+ G T LH+A + +V LL+++A+ + G +P +L+ Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681 Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 G PL A+ + ++V+ L++H AD+ A+ LG + LH Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741 Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Q + + N + D PL + ++ + V + F + K Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801 Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319 R ++ + D++E + GEEL + +++R++R + E+ KEL+ F Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846 Score = 45.8 bits (107), Expect = 1e-04 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92 LD+ ++ K E L + N + ++LLD ++ + G + +H+AA D+L Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318 Query: 93 EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152 + +L++ E+ + T + T LH+A + + + LL + A ++RA Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370 Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 G PL A N ++ LL++ GA I A G T LH+ Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410 Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 S+ GH ++ L V N + TP +A G+T + ++L+Q + + Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463 Score = 44.3 bits (103), Expect = 4e-04 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LLL + G T LH+A+ +L L++ A+P Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +T LH+A + + + LL +A V+A+A + Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA + +V+LL+E+ A+ + G+T LHI Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509 Score = 36.6 bits (83), Expect = 0.085 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%) Query: 75 RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134 R A T+ AA NL+ AL + ++ TC G LH+A +V +V Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62 Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194 LL + + G L AA +E+VR L+ +GA++ AQ Sbjct: 63 ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109 Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254 G T L++ + + ++ LL + + V G TP +A +G+ Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158 Query: 255 MFQHLM 260 + HL+ Sbjct: 159 VVAHLI 164 >gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] Length = 1719 Score = 65.1 bits (157), Expect = 2e-10 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA Y + A +L+E G T LH+AV + N+++V+ LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 R SP + + G PL AA N E+ R L+++G A+ G T Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254 LH+ + + +M LLLS +G+ + N GLTP L EG+ V Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686 Query: 255 MFQHLMQKRRHIQWTYGPL 273 + +H + + Y PL Sbjct: 687 LIKHGVMVDATTRMGYTPL 705 Score = 60.1 bits (144), Expect = 7e-09 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%) Query: 48 PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107 P L + ND + +LL + G T LHIAA Y+NL A +L+ + F Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P G T LHIA NV +VR LL R A + + PL Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227 AA I +L++HGA I+A+ G + +H+ + LLL YD D Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332 Query: 228 HLQPLDLVPNH 238 + L P H Sbjct: 333 DITLDHLTPLH 343 Score = 49.3 bits (116), Expect = 1e-05 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A ++ +V+ L+ + +G + ALHIAA D+ A VL++ P Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P G T LHIA +N+N+ + LL R ASV+ +P+N G P Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A+ + +VRLL++ GA I + T LH Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277 Score = 48.9 bits (115), Expect = 2e-05 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L L + D+ G LH+A+ +++ + L+ E++ E Sbjct: 17 LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73 Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169 TT + G TALHIA + +VR L+ A+V+A++ G PL Sbjct: 74 TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117 Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217 AA N E+V+ L+E+GA+ G T L + + Q ++ + N Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177 Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238 +LL D + D L P H Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267 G+TP +A GN +M + L+ + I+ Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A N+L +++ LLL G T LHIAA + +E A L++ Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161 E+ G T LH+A + +V LL+++A+ + G +P +L+ Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681 Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 G PL A+ + ++V+ L++H AD+ A+ LG + LH Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741 Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Q + + N + D PL + ++ + V + F + K Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801 Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319 R ++ + D++E + GEEL + +++R++R + E+ KEL+ F Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846 Score = 45.8 bits (107), Expect = 1e-04 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92 LD+ ++ K E L + N + ++LLD ++ + G + +H+AA D+L Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318 Query: 93 EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152 + +L++ E+ + T + T LH+A + + + LL + A ++RA Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370 Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 G PL A N ++ LL++ GA I A G T LH+ Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410 Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 S+ GH ++ L V N + TP +A G+T + ++L+Q + + Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463 Score = 44.3 bits (103), Expect = 4e-04 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LLL + G T LH+A+ +L L++ A+P Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +T LH+A + + + LL +A V+A+A + Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA + +V+LL+E+ A+ + G+T LHI Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509 Score = 36.6 bits (83), Expect = 0.085 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%) Query: 75 RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134 R A T+ AA NL+ AL + ++ TC G LH+A +V +V Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62 Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194 LL + + G L AA +E+VR L+ +GA++ AQ Sbjct: 63 ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109 Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254 G T L++ + + ++ LL + + V G TP +A +G+ Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158 Query: 255 MFQHLM 260 + HL+ Sbjct: 159 VVAHLI 164 >gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] Length = 1856 Score = 65.1 bits (157), Expect = 2e-10 Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 33/199 (16%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA Y + A +L+E G T LH+AV + N+++V+ LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAH-----PNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 R SP + + G PL AA N E+ R L+++G A+ G T Sbjct: 591 RGG-------------SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNT----V 254 LH+ + + +M LLLS +G+ + N GLTP L EG+ V Sbjct: 638 PLHLAAQEGH----AEMVALLLSKQANGN-------LGNKSGLTPLHLVAQEGHVPVADV 686 Query: 255 MFQHLMQKRRHIQWTYGPL 273 + +H + + Y PL Sbjct: 687 LIKHGVMVDATTRMGYTPL 705 Score = 60.1 bits (144), Expect = 7e-09 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 22/191 (11%) Query: 48 PLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVF 107 P L + ND + +LL + G T LHIAA Y+NL A +L+ + F Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P G T LHIA NV +VR LL R A + + PL Sbjct: 235 TPQN-----GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-------------TPL 276 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD 227 AA I +L++HGA I+A+ G + +H+ + LLL YD D Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH----LDCVRLLLQYDAEID 332 Query: 228 HLQPLDLVPNH 238 + L P H Sbjct: 333 DITLDHLTPLH 343 Score = 49.3 bits (116), Expect = 1e-05 Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 23/155 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A ++ +V+ L+ + +G + ALHIAA D+ A VL++ P Sbjct: 146 TPLAVALQQGHENVVAHLI-----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--- 197 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P G T LHIA +N+N+ + LL R ASV+ +P+N G P Sbjct: 198 -NPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNF---------TPQN----GITP 242 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A+ + +VRLL++ GA I + T LH Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277 Score = 48.9 bits (115), Expect = 2e-05 Identities = 61/269 (22%), Positives = 102/269 (37%), Gaps = 70/269 (26%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L L + D+ G LH+A+ +++ + L+ E++ E Sbjct: 17 LRAARSGNLDKALDHLRNGV-DINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILET 73 Query: 110 TTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSF 169 TT + G TALHIA + +VR L+ A+V+A++ G PL Sbjct: 74 TTKK---GNTALHIAALAGQDEVVRELVNYGANVNAQSQK-------------GFTPLYM 117 Query: 170 AACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN------------ 217 AA N E+V+ L+E+GA+ G T L + + Q ++ + N Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177 Query: 218 -------------LLLSYDGHGDHLQPLDLVPNH-------------------------- 238 +LL D + D L P H Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKRRHIQ 267 G+TP +A GN +M + L+ + I+ Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIE 266 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 45/297 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A N+L +++ LLL G T LHIAA + +E A L++ Sbjct: 571 TPLHVAVHHNNLDIVK-LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS-- 627 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIY----- 161 E+ G T LH+A + +V LL+++A+ + G +P +L+ Sbjct: 628 ---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GNKSGLTPLHLVAQEGHV 681 Query: 162 ------------------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 G PL A+ + ++V+ L++H AD+ A+ LG + LH Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741 Query: 204 ILQPNKTFACQMY-NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Q + + N + D PL + ++ + V + F + K Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801 Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSF 319 R ++ + D++E + GEEL + +++R++R + E+ KEL+ F Sbjct: 802 HR---MSFPETVDEILDVSEDE--GEEL----ISFKAERRDSRDVDEE---KELLDF 846 Score = 45.8 bits (107), Expect = 1e-04 Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 41/240 (17%) Query: 33 LDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNL 92 LD+ ++ K E L + N + ++LLD ++ + G + +H+AA D+L Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318 Query: 93 EAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAF 152 + +L++ E+ + T + T LH+A + + + LL + A ++RA Sbjct: 319 DCVRLLLQYDAEI--DDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN--- 370 Query: 153 RRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 G PL A N ++ LL++ GA I A G T LH+ Sbjct: 371 ----------GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV---------- 410 Query: 213 CQMYNLLLSYDGHGDHLQPL------DLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 S+ GH ++ L V N + TP +A G+T + ++L+Q + + Sbjct: 411 -------ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463 Score = 44.3 bits (103), Expect = 4e-04 Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 23/158 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LLL + G T LH+A+ +L L++ A+P Sbjct: 373 TPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +T LH+A + + + LL +A V+A+A + Sbjct: 432 V-------SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD-------------Q 471 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA + +V+LL+E+ A+ + G+T LHI Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509 Score = 36.6 bits (83), Expect = 0.085 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%) Query: 75 RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134 R A T+ AA NL+ AL + ++ TC G LH+A +V +V Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQ-NGLNGLHLASKEGHVKMVV 62 Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDS 194 LL + + G L AA +E+VR L+ +GA++ AQ Sbjct: 63 ELLHKEIILETTTKK-------------GNTALHIAALAGQDEVVRELVNYGANVNAQSQ 109 Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTV 254 G T L++ + + ++ LL + + V G TP +A +G+ Sbjct: 110 KGFTPLYMAAQENH----LEVVKFLLENGANQN-------VATEDGFTPLAVALQQGHEN 158 Query: 255 MFQHLM 260 + HL+ Sbjct: 159 VVAHLI 164 >gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] Length = 1863 Score = 63.9 bits (154), Expect = 5e-10 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 ++PL AS+ ++ QLLL G T LHI+A ++ A VL+EA Sbjct: 477 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 534 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165 + G T LH+A ++++ + LL RRA+ + G Sbjct: 535 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 577 Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225 PL AA +++++ LL+E GA A G T LHI K Q+ + LL+Y Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 633 Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276 + + QG+TP LA EG+T M L+ K +I T LTS+ Sbjct: 634 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678 Score = 60.5 bits (145), Expect = 5e-09 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LL+ ++ G T +H+AA +L L+L++ A+P+ Sbjct: 379 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + G+TALH+A V +VR LL A V ARA + Sbjct: 438 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 477 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ + EIV+LL++H A A + G T LHI + A + ++ Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 536 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 + +G TP +A G+ + + L+Q+R Sbjct: 537 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 565 Score = 59.7 bits (143), Expect = 9e-09 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%) Query: 3 GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62 GF P A + + L + L LH+ +K +S L +++ V Sbjct: 142 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 201 Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 +++++ T + G T LHIAA Y N+ A +L+ + F A G T LH Sbjct: 202 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 250 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 +A N N+V+ LL R + A+ G PL AA +++V LL Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 297 Query: 183 IEHGADIRAQDSLGNTVLHI 202 +E GA + A+ G + LH+ Sbjct: 298 LERGAPLLARTKNGLSPLHM 317 Score = 55.1 bits (131), Expect = 2e-07 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A+K L V + LLL G G T LH+AA YDN + AL+L+E A+P Sbjct: 544 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 A G T LHIA + + LL A + + G Sbjct: 603 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 642 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ ++V LL++ GA+I G T LH+ + A + D Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 H G TP +A GN M L+++ ++ Sbjct: 703 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 733 Score = 50.8 bits (120), Expect = 4e-06 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL AS+E ++ LLLD ++ G T+LH+AA D + A +L + + Sbjct: 643 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 699 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 G T L +A NV +V LL + A+V+A+ G P Sbjct: 700 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 743 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L AA I+ +L++HGA A + GNT L I Sbjct: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 779 Score = 46.2 bits (108), Expect = 1e-04 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A++ V+ +LLL+ + R G + LH+AA D++E L++ + Sbjct: 280 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 337 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 + T + TALH+A + + + LL +RA+ +ARA G P Sbjct: 338 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 380 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L A N +++ LL+++GA I+A G T +H+ Sbjct: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416 Score = 40.0 bits (92), Expect = 0.008 Identities = 49/188 (26%), Positives = 84/188 (44%), Gaps = 27/188 (14%) Query: 41 QKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100 QK + LRA++ +L + + L D+ G ALH+AA E + L++ Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ 60 Query: 101 AAPELVFEPTTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRN 158 EL+ ++ ++ G TALHIA + +V+ L+ A+++A++ Sbjct: 61 ---ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN--------- 108 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 218 G PL AA N ++V+ L+E+GA+ G T L + + Q + Q + Sbjct: 109 ----GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAI 160 Query: 219 LLSYDGHG 226 LL D G Sbjct: 161 LLENDTKG 168 Score = 37.4 bits (85), Expect = 0.050 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 52 ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111 A+KE + ++++LL V G TALHIA+L E VL++ + Sbjct: 50 AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 103 Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165 ++ G T L++A ++++V+ LL A+ S AT F +P + H Sbjct: 104 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 160 Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204 L AA + + LL++ H AD++++ + G T LHI Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220 Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 N A + N + D G+TP +A GNT M + L+ + Sbjct: 221 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 267 >gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] Length = 1872 Score = 63.9 bits (154), Expect = 5e-10 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 ++PL AS+ ++ QLLL G T LHI+A ++ A VL+EA Sbjct: 498 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 555 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165 + G T LH+A ++++ + LL RRA+ + G Sbjct: 556 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 598 Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225 PL AA +++++ LL+E GA A G T LHI K Q+ + LL+Y Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 654 Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276 + + QG+TP LA EG+T M L+ K +I T LTS+ Sbjct: 655 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699 Score = 60.5 bits (145), Expect = 5e-09 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LL+ ++ G T +H+AA +L L+L++ A+P+ Sbjct: 400 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + G+TALH+A V +VR LL A V ARA + Sbjct: 459 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 498 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ + EIV+LL++H A A + G T LHI + A + ++ Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 557 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 + +G TP +A G+ + + L+Q+R Sbjct: 558 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 586 Score = 59.7 bits (143), Expect = 9e-09 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%) Query: 3 GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62 GF P A + + L + L LH+ +K +S L +++ V Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222 Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 +++++ T + G T LHIAA Y N+ A +L+ + F A G T LH Sbjct: 223 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 271 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 +A N N+V+ LL R + A+ G PL AA +++V LL Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 318 Query: 183 IEHGADIRAQDSLGNTVLHI 202 +E GA + A+ G + LH+ Sbjct: 319 LERGAPLLARTKNGLSPLHM 338 Score = 55.1 bits (131), Expect = 2e-07 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A+K L V + LLL G G T LH+AA YDN + AL+L+E A+P Sbjct: 565 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 A G T LHIA + + LL A + + G Sbjct: 624 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 663 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ ++V LL++ GA+I G T LH+ + A + D Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 H G TP +A GN M L+++ ++ Sbjct: 724 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754 Score = 50.8 bits (120), Expect = 4e-06 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL AS+E ++ LLLD ++ G T+LH+AA D + A +L + + Sbjct: 664 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 720 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 G T L +A NV +V LL + A+V+A+ G P Sbjct: 721 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 764 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L AA I+ +L++HGA A + GNT L I Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800 Score = 48.5 bits (114), Expect = 2e-05 Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 61/251 (24%) Query: 47 SPLLRASKENDLSVLRQLL----------------------------LDCTCDVRQRGAL 78 +PL A++EN + V++ LL + + +G + Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191 Query: 79 GETALHIAALYDNLEAALVLM------EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132 ALHIAA D+ ++A +L+ + +++ TT F T LHIA NVN+ Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNV 248 Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192 LL R A+V A RN G PL A+ + +V+LL++ G I A+ Sbjct: 249 ATLLLNRGAAVDFTA---------RN----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295 Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 G T LH + Q+ LLL + PL L GL+P +A + Sbjct: 296 TRDGLTPLHCAARSGHD----QVVELLL------ERGAPL-LARTKNGLSPLHMAAQGDH 344 Query: 253 TVMFQHLMQKR 263 +HL+Q + Sbjct: 345 VECVKHLLQHK 355 Score = 46.2 bits (108), Expect = 1e-04 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A++ V+ +LLL+ + R G + LH+AA D++E L++ + Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 358 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 + T + TALH+A + + + LL +RA+ +ARA G P Sbjct: 359 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 401 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L A N +++ LL+++GA I+A G T +H+ Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437 Score = 40.0 bits (92), Expect = 0.008 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%) Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176 G ALH+A +V LV+ LL R +SV + G L A+ Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-------------GNTALHIASLAGQA 110 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHI 202 E+V++L++ GA+I AQ G T L++ Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYM 136 Score = 38.5 bits (88), Expect = 0.022 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 27/179 (15%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L + + L D+ G ALH+AA E + L++ EL+ Sbjct: 36 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ---ELLGRG 87 Query: 110 TTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 ++ ++ G TALHIA + +V+ L+ A+++A++ G PL Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-------------GFTPL 134 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226 AA N ++V+ L+E+GA+ G T L + + Q + Q +LL D G Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAILLENDTKG 189 Score = 37.4 bits (85), Expect = 0.050 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 52 ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111 A+KE + ++++LL V G TALHIA+L E VL++ + Sbjct: 71 AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 124 Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165 ++ G T L++A ++++V+ LL A+ S AT F +P + H Sbjct: 125 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 181 Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204 L AA + + LL++ H AD++++ + G T LHI Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241 Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 N A + N + D G+TP +A GNT M + L+ + Sbjct: 242 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 288 >gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] Length = 3957 Score = 63.9 bits (154), Expect = 5e-10 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 31/232 (13%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 ++PL AS+ ++ QLLL G T LHI+A ++ A VL+EA Sbjct: 498 QTPLHIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA- 555 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165 + G T LH+A ++++ + LL RRA+ + G Sbjct: 556 ----HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-------------GLT 598 Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225 PL AA +++++ LL+E GA A G T LHI K Q+ + LL+Y Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA----KKNQMQIASTLLNYGAE 654 Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQW-TYGPLTSI 276 + + QG+TP LA EG+T M L+ K +I T LTS+ Sbjct: 655 TN-------IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699 Score = 60.5 bits (145), Expect = 5e-09 Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A K+N + V+ +LL+ ++ G T +H+AA +L L+L++ A+P+ Sbjct: 400 TPLHIACKKNRIKVM-ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + G+TALH+A V +VR LL A V ARA + Sbjct: 459 VT-------NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------Q 498 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ + EIV+LL++H A A + G T LHI + A + ++ Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS- 557 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 + +G TP +A G+ + + L+Q+R Sbjct: 558 ----------LATKKGFTPLHVAAKYGSLDVAKLLLQRR 586 Score = 59.7 bits (143), Expect = 9e-09 Identities = 53/200 (26%), Positives = 85/200 (42%), Gaps = 24/200 (12%) Query: 3 GFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLR 62 GF P A + + L + L LH+ +K +S L +++ V Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222 Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 +++++ T + G T LHIAA Y N+ A +L+ + F A G T LH Sbjct: 223 KMMVNRTTES------GFTPLHIAAHYGNVNVATLLLNRGAAVDFT-----ARNGITPLH 271 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 +A N N+V+ LL R + A+ G PL AA +++V LL Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHDQVVELL 318 Query: 183 IEHGADIRAQDSLGNTVLHI 202 +E GA + A+ G + LH+ Sbjct: 319 LERGAPLLARTKNGLSPLHM 338 Score = 55.1 bits (131), Expect = 2e-07 Identities = 60/222 (27%), Positives = 87/222 (39%), Gaps = 34/222 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A+K L V + LLL G G T LH+AA YDN + AL+L+E A+P Sbjct: 565 TPLHVAAKYGSLDVAK-LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 A G T LHIA + + LL A + + G Sbjct: 624 -------ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-------------VTKQGV 663 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL A+ ++V LL++ GA+I G T LH+ + A + D Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 H G TP +A GN M L+++ ++ Sbjct: 724 H-----------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754 Score = 50.8 bits (120), Expect = 4e-06 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL AS+E ++ LLLD ++ G T+LH+AA D + A +L + + Sbjct: 664 TPLHLASQEGHTDMVT-LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-- 720 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 G T L +A NV +V LL + A+V+A+ G P Sbjct: 721 ---QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-------------GYTP 764 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L AA I+ +L++HGA A + GNT L I Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800 Score = 48.5 bits (114), Expect = 2e-05 Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 61/251 (24%) Query: 47 SPLLRASKENDLSVLRQLL----------------------------LDCTCDVRQRGAL 78 +PL A++EN + V++ LL + + +G + Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191 Query: 79 GETALHIAALYDNLEAALVLM------EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNL 132 ALHIAA D+ ++A +L+ + +++ TT F T LHIA NVN+ Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNV 248 Query: 133 VRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192 LL R A+V A RN G PL A+ + +V+LL++ G I A+ Sbjct: 249 ATLLLNRGAAVDFTA---------RN----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295 Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 G T LH + Q+ LLL + PL L GL+P +A + Sbjct: 296 TRDGLTPLHCAARSGHD----QVVELLL------ERGAPL-LARTKNGLSPLHMAAQGDH 344 Query: 253 TVMFQHLMQKR 263 +HL+Q + Sbjct: 345 VECVKHLLQHK 355 Score = 46.2 bits (108), Expect = 1e-04 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 19/156 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A++ V+ +LLL+ + R G + LH+AA D++E L++ + Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV- 358 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 + T + TALH+A + + + LL +RA+ +ARA G P Sbjct: 359 -DDVTLDYL---TALHVAAHCGHYRVTKLLLDKRANPNARALN-------------GFTP 401 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L A N +++ LL+++GA I+A G T +H+ Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437 Score = 40.0 bits (92), Expect = 0.008 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%) Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176 G ALH+A +V LV+ LL R +SV + G L A+ Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-------------GNTALHIASLAGQA 110 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHI 202 E+V++L++ GA+I AQ G T L++ Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYM 136 Score = 38.5 bits (88), Expect = 0.022 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 27/179 (15%) Query: 50 LRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEP 109 LRA++ +L + + L D+ G ALH+AA E + L++ EL+ Sbjct: 36 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAK----EGHVGLVQ---ELLGRG 87 Query: 110 TTCEAFA--GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 ++ ++ G TALHIA + +V+ L+ A+++A++ G PL Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-------------GFTPL 134 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHG 226 AA N ++V+ L+E+GA+ G T L + + Q + Q +LL D G Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN----QAVAILLENDTKG 189 Score = 37.4 bits (85), Expect = 0.050 Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 52 ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111 A+KE + ++++LL V G TALHIA+L E VL++ + Sbjct: 71 AAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI-----N 124 Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH------ 165 ++ G T L++A ++++V+ LL A+ S AT F +P + H Sbjct: 125 AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGF--TPLAVALQQGHNQAVAI 181 Query: 166 -------------PLSFAACVNSEEIVRLLIE--HGADIRAQDSL------GNTVLHILI 204 L AA + + LL++ H AD++++ + G T LHI Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241 Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 N A + N + D G+TP +A GNT M + L+ + Sbjct: 242 HYGNVNVATLLLNRGAAVD-----------FTARNGITPLHVASKRGNTNMVKLLLDR 288 >gi|68131557 ankyrin repeat domain 28 [Homo sapiens] Length = 1053 Score = 59.7 bits (143), Expect = 9e-09 Identities = 58/198 (29%), Positives = 90/198 (45%), Gaps = 29/198 (14%) Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 Q+LL + DV R +T LHIAA ++ A EA L+ + AG+TALH Sbjct: 91 QVLLKHSADVNARDKNWQTPLHIAAANKAVKCA----EALVPLLSNVNVSDR-AGRTALH 145 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 A + + +V+ LL+R A+++A F + R I++ AA + E+V+LL Sbjct: 146 HAAFSGHGEMVKLLLSRGANINA------FDKKDRRAIHW-------AAYMGHIEVVKLL 192 Query: 183 IEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLT 242 + HGA++ +D T LH + + Y L L D + PN G T Sbjct: 193 VSHGAEVTCKDKKSYTPLH--AAASSGMISVVKYLLDLGVDMN---------EPNAYGNT 241 Query: 243 PFKLAGVEGNTVMFQHLM 260 P +A G V+ L+ Sbjct: 242 PLHVACYNGQDVVVNELI 259 Score = 53.1 bits (126), Expect = 9e-07 Identities = 56/221 (25%), Positives = 86/221 (38%), Gaps = 36/221 (16%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ ++ +LL+ DV + G+T LH+ AL+ + ++++ + Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI- 332 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRSP 156 CE G T LHIA + L+ L+T A + R A + F Sbjct: 333 ----DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388 Query: 157 RNLIY----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQ 206 R L+ FG L AA + E + LL+ GAD +D G + LH Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448 Query: 207 PNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLA 247 N Y L + G G + LD +G TP A Sbjct: 449 CN-------YQCLFALVGSGASVNDLD----ERGCTPLHYA 478 Score = 44.7 bits (104), Expect = 3e-04 Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 17/122 (13%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G TALH A + +L+E + VF+ T AF+ LH AV+N N L+ Sbjct: 756 GYTALHWACYNGHETCVELLLE---QEVFQKTEGNAFS---PLHCAVINDNEGAAEMLID 809 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 + AT + G PL AA + E ++LL+ H A + + DS G T Sbjct: 810 TLGASIVNATDSK-----------GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858 Query: 199 VL 200 L Sbjct: 859 PL 860 Score = 43.9 bits (102), Expect = 5e-04 Identities = 50/181 (27%), Positives = 75/181 (41%), Gaps = 28/181 (15%) Query: 75 RGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVR 134 R + G T +H++A ++ L+++A + P T + G TALH A N + V Sbjct: 715 RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNH-GYTALHWACYNGHETCVE 773 Query: 135 ALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH-GADI-RAQ 192 LL + V + G AF PL A ++E +LI+ GA I A Sbjct: 774 LLLEQ--EVFQKTEGNAF------------SPLHCAVINDNEGAAEMLIDTLGASIVNAT 819 Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 DS G T LH T + LLLS++ + + + G TP +A G Sbjct: 820 DSKGRTPLHAAAF----TDHVECLQLLLSHNAQVNSV-------DSTGKTPLMMAAENGQ 868 Query: 253 T 253 T Sbjct: 869 T 869 Score = 43.9 bits (102), Expect = 5e-04 Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 25/181 (13%) Query: 83 LHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142 LH A + DN AA +L++ + T + G+T LH A +V ++ LL+ A Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSK---GRTPLHAAAFTDHVECLQLLLSHNAQ 848 Query: 143 VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG-ADIRAQDSLGNTVLH 201 V++ + G+ PL AA V +L+ A++ QD+ NT LH Sbjct: 849 VNSVDST-------------GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895 Query: 202 ILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + + ++T A + + + L N TP +A G T++ Q L+ Sbjct: 896 LACSKGHETSALLILEKITD--------RNLINATNAALQTPLHVAARNGLTMVVQELLG 947 Query: 262 K 262 K Sbjct: 948 K 948 Score = 43.1 bits (100), Expect = 0.001 Identities = 36/126 (28%), Positives = 58/126 (46%), Gaps = 17/126 (13%) Query: 78 LGETALHIAALYDNLEAALVLM-EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRAL 136 L T +H AA + E +L+ A P+ + + GQT L ++V+N + + V +L Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVD---IQDGNGQTPLMLSVLNGHTDCVYSL 672 Query: 137 LTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLG 196 L + A+V A+ +G L A EE V L++HGA +DS G Sbjct: 673 LNKGANVDAKDK-------------WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719 Query: 197 NTVLHI 202 T +H+ Sbjct: 720 RTPIHL 725 Score = 38.5 bits (88), Expect = 0.022 Identities = 45/163 (27%), Positives = 66/163 (40%), Gaps = 32/163 (19%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ +SV++ LL D D+ + A G T LH+A Y+ + +V Sbjct: 208 TPLHAAASSGMISVVKYLL-DLGVDMNEPNAYGNTPLHVAC-YNGQDV----------VV 255 Query: 107 FEPTTCEAFAGQ------TALHIAVVNQNVNLVRALLT-RRASVSARATGTAFRRSPRNL 159 E C A Q T LH A + + L LL A V+ ++ Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD---------- 305 Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 G+ PL A + +I+ GA I +D GNT LHI Sbjct: 306 ---GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345 Score = 38.1 bits (87), Expect = 0.029 Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 2/100 (2%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 ++PL+ A++ + + L+ + ++ + TALH+A + +AL+++E + Sbjct: 857 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDR 916 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSA 145 T A QT LH+A N +V+ LL + ASV A Sbjct: 917 NLINATNAAL--QTPLHVAARNGLTMVVQELLGKGASVLA 954 Score = 36.6 bits (83), Expect = 0.085 Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 15/96 (15%) Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177 +T LH A + ++ L+ A V+A+ + PL A SEE Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLT-------------PLHRAVASCSEE 88 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFAC 213 V++L++H AD+ A+D T LH I NK C Sbjct: 89 AVQVLLKHSADVNARDKNWQTPLH--IAAANKAVKC 122 Score = 35.8 bits (81), Expect = 0.14 Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 32/174 (18%) Query: 53 SKENDLSVLRQLL-LDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111 + E L VL + D D R + + LH+AA + + +A VL+++ +L ++ Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATI--SPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582 Query: 112 CEAFAGQTALHIA-----------VVNQNVN-LVRALLTRRASVSARATG--------TA 151 G+T L +A ++NQ + LV+ + +R + A AT Sbjct: 583 -----GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637 Query: 152 FRRSPRNLIYF----GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 P+N + G+ PL + + V L+ GA++ A+D G T LH Sbjct: 638 GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALH 691 >gi|67906195 ankyrin repeat and sterile alpha motif domain containing 6 [Homo sapiens] Length = 871 Score = 58.9 bits (141), Expect = 2e-08 Identities = 52/155 (33%), Positives = 68/155 (43%), Gaps = 18/155 (11%) Query: 49 LLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIA-ALYDNLEAALVLMEAAPELVF 107 LLRA + D R+LL + +RGA E A A AA AP Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPV--- 69 Query: 108 EPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPL 167 P C AG TAL A + LVR LL R ASV++R ++G L Sbjct: 70 -PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRN-------------HYGWSAL 115 Query: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 AA + LL++HGAD+ AQ+ LG +VL + Sbjct: 116 MQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTV 150 Score = 34.7 bits (78), Expect = 0.32 Identities = 57/254 (22%), Positives = 95/254 (37%), Gaps = 48/254 (18%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 S L++A++ +SV LLLD DV + LG + L +A+ +L +L+EA + Sbjct: 113 SALMQAARFGHVSVAH-LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171 Query: 107 FEPTTCEAFA---------GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPR 157 + E TAL A+ + + +VR L+ A + A Sbjct: 172 HHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTV------- 224 Query: 158 NLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI------------- 204 G PL AA + + L+E GA+ L T + + Sbjct: 225 -----GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDP 279 Query: 205 ------------LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 +P+ A +M N L + + ++LV N G TP LA V G Sbjct: 280 LTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLV-NGDGATPLMLAAVTGQ 338 Query: 253 TVMFQHLMQKRRHI 266 + Q L+++ + Sbjct: 339 LALVQLLVERHADV 352 Score = 30.4 bits (67), Expect = 6.1 Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 12/89 (13%) Query: 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176 G T L +A V + LV+ L+ R A V + + G L A ++ Sbjct: 326 GATPLMLAAVTGQLALVQLLVERHADVDKQDS------------VHGWTALMQATYHGNK 373 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILIL 205 EIV+ L+ GAD+ + G T +++L Sbjct: 374 EIVKYLLNQGADVTLRAKNGYTAFDLVML 402 >gi|24233530 ankyrin repeat domain 44 [Homo sapiens] Length = 919 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 19/155 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL RA + Q+L+ + DV R +T LH+AA ++ A V++ + Sbjct: 51 TPLHRAVASRSEEAV-QVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIP-----L 104 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 G+TALH A +N +V +V LL + A+++A F + R +++ Sbjct: 105 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA------FDKKDRRALHW---- 154 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 AA + ++V LLI HGA++ +D G T LH Sbjct: 155 ---AAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186 Score = 47.8 bits (112), Expect = 4e-05 Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 28/180 (15%) Query: 82 ALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRA 141 ALH AA +L+ +L+ E+ TC+ G T LH A N +N+V+ LL Sbjct: 151 ALHWAAYMGHLDVVALLINHGAEV-----TCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205 Query: 142 SVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 + + +G L A + +V LI++GA++ ++ G T LH Sbjct: 206 EID-------------EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252 Query: 202 ILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + + LL +G ++Q D G +P + V G Q L+Q Sbjct: 253 FAAASTHGALCLE----LLVNNGADVNIQSKD------GKSPLHMTAVHGRFTRSQTLIQ 302 Score = 46.6 bits (109), Expect = 8e-05 Identities = 64/292 (21%), Positives = 109/292 (37%), Gaps = 38/292 (13%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 +SPL A+ L ++LL D+ R G TAL +AA + E L+ + Sbjct: 543 KSPLHLAAYNGHHQAL-EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165 + + +T LH +V+N + +R LL + A A ++P L H Sbjct: 602 FVKDNVTK----RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657 Query: 166 -----------------------PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 L EE V++L+E I +DS G T LH Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717 Query: 203 LILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 + + T+ ++ + LS + ++QG TP A GN + L+++ Sbjct: 718 AAARGHATWLSELLQMALSEED--------CCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769 Query: 263 RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVK 314 + ++ P T + I+ G S L + S R +TP++ Sbjct: 770 KCFRKFIGNPFTPL--HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLR 819 Score = 41.2 bits (95), Expect = 0.003 Identities = 33/119 (27%), Positives = 52/119 (43%), Gaps = 18/119 (15%) Query: 83 LHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142 LH+AAL + + L+ + FE T + F G+T LH A NV ++ L Sbjct: 351 LHLAALNAHSDCCRKLLSSG----FEIDTPDKF-GRTCLHAAAAGGNVECIKLL------ 399 Query: 143 VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 +++G F + + G PL +AA + L+ GA++ D G T LH Sbjct: 400 ---QSSGADFHKKDK----CGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALH 451 Score = 39.7 bits (91), Expect = 0.010 Identities = 40/151 (26%), Positives = 61/151 (40%), Gaps = 28/151 (18%) Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177 +T LH+A + ++ L+ A V+A+ PL A SEE Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDN-------------MWLTPLHRAVASRSEE 63 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ--MYNLLLSYDGHGDHLQPLDLV 235 V++LI+H AD+ A+D T LH + NK C + LL S + V Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLH--VAAANKAVKCAEVIIPLLSSVN-----------V 110 Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 + G T A + G+ M L+ K +I Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANI 141 Score = 39.7 bits (91), Expect = 0.010 Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 25/175 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ ++ +LL++ DV + G++ LH+ A++ + L++ E+ Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI- 307 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSA----------RATGTAFRRSP 156 C G T LH+A + L+ L T A + A A Sbjct: 308 ----DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363 Query: 157 RNLIY----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLH 201 R L+ FG L AA + E ++LL GAD +D G T LH Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418 Score = 38.9 bits (89), Expect = 0.017 Identities = 54/217 (24%), Positives = 89/217 (41%), Gaps = 25/217 (11%) Query: 51 RASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPT 110 R KE + ++ + LL + R G ++H AA Y + + +L+E FE + Sbjct: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT-NSGFEES 537 Query: 111 TCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFA 170 ++ A ++ LH+A N + + LL + R G L A Sbjct: 538 --DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK-------------GRTALDLA 582 Query: 171 ACVNSEEIVRLLIEHGADIRAQDSL-GNTVLHILILQPNKTFACQMYNLLLSYDGHGDHL 229 A E V LI GA I +D++ T LH ++ N C LLL D+ Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI--NGHTLC--LRLLLEI---ADNP 635 Query: 230 QPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 + +D V + +G TP LA G+ L++K ++ Sbjct: 636 EAVD-VKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV 671 Score = 38.1 bits (87), Expect = 0.029 Identities = 41/163 (25%), Positives = 63/163 (38%), Gaps = 31/163 (19%) Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 Q+LL+ + + + G T LH AA + L++ A L E + G T LH Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA--LSEEDCCFKDNQGYTPLH 752 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH----------------- 165 A N N N + LL ++ + G F +P + +H Sbjct: 753 WACYNGNENCIEVLLEQKCF--RKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSIVS 808 Query: 166 --------PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200 PL AA + E ++LL+ H A + A D+ G T L Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851 Score = 37.4 bits (85), Expect = 0.050 Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 20/157 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ ++V++ LL + ++ + G TALHIA Y+ +A + + V Sbjct: 183 TPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIAC-YNGQDAVVNELIDYGANV 240 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR-ASVSARATGTAFRRSPRNLIYFGEH 165 +P G T LH A + + L LL A V+ ++ G+ Sbjct: 241 NQPNN----NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-------------GKS 283 Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL A + LI++G +I D GNT LH+ Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320 Score = 32.3 bits (72), Expect = 1.6 Identities = 56/241 (23%), Positives = 91/241 (37%), Gaps = 56/241 (23%) Query: 65 LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124 LL ++ G T LH AA N+E +L + + + C G+T LH A Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF-HKKDKC----GRTPLHYA 420 Query: 125 VVNQNVNLVRALLTRRASVS-------ARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177 N + + + L+T A+V+ A RN G A NSEE Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN------AHDNSEE 474 Query: 178 IVR--------------LLIEHGADIRAQDSLGNTVLH------------ILILQPNKTF 211 + R L+++ A+ +D G +H +L+ + N F Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534 Query: 212 ------ACQMYNLLLSYDGHGDHLQPL-----DL-VPNHQGLTPFKLAGVEGNTVMFQHL 259 A + L +Y+GH L+ L DL + + +G T LA +G+T + L Sbjct: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594 Query: 260 M 260 + Sbjct: 595 I 595 >gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] Length = 319 Score = 57.8 bits (138), Expect = 4e-08 Identities = 55/187 (29%), Positives = 85/187 (45%), Gaps = 34/187 (18%) Query: 50 LRASKENDLSVLRQLLLDCT----CDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 L+A+ EN L V+ + L D CD +R TALH A L +L LMEA ++ Sbjct: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKR-----TALHRACLEGHLAIVEKLMEAGAQI 179 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRS 155 F TA+H A N+++++ LL + A +SAR A T Sbjct: 180 EFRD-----MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC 234 Query: 156 PRNLIYF----------GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILIL 205 +LI G+ PL A +N +++RLLI +GAD+ ++ G T + +++ Sbjct: 235 AEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294 Query: 206 QPNKTFA 212 N T A Sbjct: 295 WQNGTKA 301 Score = 33.5 bits (75), Expect = 0.72 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 7/109 (6%) Query: 39 LQQKRILESPLLR-ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALV 97 ++ + +LES + AS+ +L VL+ LLL+ + R L TALH+A + E A Sbjct: 179 IEFRDMLESTAIHWASRGGNLDVLK-LLLNKGAKISARDKLLSTALHVAVRTGHYECAEH 237 Query: 98 LMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR 146 L+ +L + G T LH AV ++R L+ A ++ + Sbjct: 238 LIACEADL-----NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIK 281 >gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] Length = 4377 Score = 57.4 bits (137), Expect = 5e-08 Identities = 61/222 (27%), Positives = 94/222 (42%), Gaps = 34/222 (15%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL +++E V LLD + G T LH+AA Y LE A +L++ A+P+ Sbjct: 534 TPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 + +G T LH+A N + LL + AS A A G Sbjct: 593 AAGK-------SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN-------------GY 632 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 PL AA N +I L+E+GAD A G +H+ + + M +LLL + Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH----VDMVSLLLGRNA 688 Query: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHI 266 + + + N GLTP LA E + + L+ + H+ Sbjct: 689 NVN-------LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723 Score = 55.5 bits (132), Expect = 2e-07 Identities = 53/185 (28%), Positives = 78/185 (42%), Gaps = 22/185 (11%) Query: 20 PSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLL--DCTCDVRQRGA 77 P + +Q DQ + L K + P L + D + LLL D DV + Sbjct: 176 PLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS- 234 Query: 78 LGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALL 137 G T LHIAA Y N+ A +L+ A + F A T LH+A N N+V+ LL Sbjct: 235 -GFTPLHIAAHYGNINVATLLLNRAAAVDF-----TARNDITPLHVASKRGNANMVKLLL 288 Query: 138 TRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGN 197 R A + A+ G PL A E++V +L++ A I ++ G Sbjct: 289 DRGAKIDAKTRD-------------GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335 Query: 198 TVLHI 202 + LH+ Sbjct: 336 SPLHM 340 Score = 54.3 bits (129), Expect = 4e-07 Identities = 63/237 (26%), Positives = 93/237 (39%), Gaps = 41/237 (17%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME--AAPE 104 +PL A+K L V LLL + G G T LH+AA YDN + AL+L++ A+P Sbjct: 567 TPLHVAAKYGKLEVAN-LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALL---------TRRASVSARATGTAFRRS 155 A G T LHIA +++ LL TR+ S Sbjct: 626 -------AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678 Query: 156 PRNLIY-----------FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 +L+ G PL AA + + +L+ GA + AQ +G T LH+ Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738 Query: 205 LQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 N ++ N LL + + G TP A +G+T + L+Q Sbjct: 739 HYGN----IKIVNFLLQHSAKVN-------AKTKNGYTPLHQAAQQGHTHIINVLLQ 784 Score = 50.8 bits (120), Expect = 4e-06 Identities = 55/212 (25%), Positives = 81/212 (38%), Gaps = 30/212 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A K+N + V+ +LLL ++ G T +H+AA ++ LM Sbjct: 402 TPLHIACKKNRIKVM-ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS-- 458 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR------------- 153 P T G+TALH+A + +VR L+ A V A+A Sbjct: 459 --PNTTNV-RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515 Query: 154 -------RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQ 206 SP G PL +A E++ L++HGA + G T LH+ Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA-- 573 Query: 207 PNKTFACQMYNLLLSYDGHGDHLQPLDLVPNH 238 K ++ NLLL D L P H Sbjct: 574 --KYGKLEVANLLLQKSASPDAAGKSGLTPLH 603 Score = 48.5 bits (114), Expect = 2e-05 Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 29/205 (14%) Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 ++LLD + + G + LH+A D+L +L++ + + T + TALH Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH--NVPVDDVTNDYL---TALH 372 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 +A + + + LL ++A+ +A+A G PL A N +++ LL Sbjct: 373 VAAHCGHYKVAKVLLDKKANPNAKALN-------------GFTPLHIACKKNRIKVMELL 419 Query: 183 IEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLT 242 ++HGA I+A G T +H+ + Q+ + HG N +G T Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH-------HGASPN----TTNVRGET 468 Query: 243 PFKLAGVEGNTVMFQHLMQKRRHIQ 267 +A G + ++L+Q ++ Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVE 493 Score = 46.6 bits (109), Expect = 8e-05 Identities = 51/176 (28%), Positives = 71/176 (40%), Gaps = 26/176 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 SPL A++ + L+ + QLLL V TALH+AA + + A VL++ Sbjct: 336 SPLHMATQGDHLNCV-QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN-- 392 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATG-------TAFR------ 153 +A G T LHIA + ++ LL AS+ A AF Sbjct: 393 ---PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449 Query: 154 -------RSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 SP GE L AA E+VR L++ GA + A+ T LHI Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505 Score = 44.7 bits (104), Expect = 3e-04 Identities = 41/148 (27%), Positives = 66/148 (44%), Gaps = 22/148 (14%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G ALH+A+ ++E L++ + G TALHIA + +V+ L+T Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANV-----DAATKKGNTALHIASLAGQAEVVKVLVT 128 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 A+V+A++ G PL AA N E+V+ L+++GA G T Sbjct: 129 NGANVNAQSQN-------------GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFT 175 Query: 199 VLHILILQPNKTFACQMYNLLLSYDGHG 226 L + + Q + Q+ +LLL D G Sbjct: 176 PLAVALQQGHD----QVVSLLLENDTKG 199 Score = 32.3 bits (72), Expect = 1.6 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 6/96 (6%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A++E+ ++V ++L++ V + +G T LH+ Y N++ L++ + ++ Sbjct: 699 TPLHLAAQEDRVNVA-EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV- 756 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRAS 142 + G T LH A + +++ LL AS Sbjct: 757 ----NAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788 >gi|50511945 cajalin 2 isoform a [Homo sapiens] Length = 1248 Score = 55.8 bits (133), Expect = 1e-07 Identities = 56/184 (30%), Positives = 84/184 (45%), Gaps = 23/184 (12%) Query: 40 QQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLM 99 +Q E+ L A++ V+ LL + T D R + ET L +AALY L +++ Sbjct: 123 EQNNENETALHCAAQYGHSEVVAVLLEELT-DPTIRNSKLETPLDLAALYGRLRVVKMII 181 Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARAT-GTAFRRSPRN 158 A P L+ +C T LH+A N + +V+ LL VS + G+A Sbjct: 182 SAHPNLM----SCNT-RKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE---- 232 Query: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 218 AA ++VR+L+E G D +DSLG TVL IL P++ + Q+ L Sbjct: 233 -----------AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQK-SLQIATL 280 Query: 219 LLSY 222 L Y Sbjct: 281 LQEY 284 Score = 37.7 bits (86), Expect = 0.038 Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 16/93 (17%) Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAA 171 C +G TALH A +N + ++V LL AS + N YF P+ AA Sbjct: 54 CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVAD----------NKGYF---PIHLAA 100 Query: 172 CVNSEEIVRLLIEHG---ADIRAQDSLGNTVLH 201 EIV++LI HG + + Q++ T LH Sbjct: 101 WKGDVEIVKILIHHGPSHSRVNEQNNENETALH 133 Score = 30.0 bits (66), Expect = 7.9 Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 34/207 (16%) Query: 56 NDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEA- 114 N LS+ R ++CT + G TALH AAL + + L L++ +E +T A Sbjct: 42 NLLSIWRGPNVNCT------DSSGYTALHHAALNGHKDIVLKLLQ------YEASTNVAD 89 Query: 115 FAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVN 174 G +H+A +V +V+ L+ S S R + +N E L AA Sbjct: 90 NKGYFPIHLAAWKGDVEIVKILIHHGPSHS--------RVNEQN--NENETALHCAAQYG 139 Query: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDL 234 E+V +L+E D ++S T L + L ++ +++S P + Sbjct: 140 HSEVVAVLLEELTDPTIRNSKLETPLDLAALYGR----LRVVKMIIS-------AHPNLM 188 Query: 235 VPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 N + TP LA G+ + Q L++ Sbjct: 189 SCNTRKHTPLHLAARNGHKAVVQVLLE 215 >gi|55742857 ankyrin repeat domain 6 [Homo sapiens] Length = 722 Score = 54.3 bits (129), Expect = 4e-07 Identities = 38/108 (35%), Positives = 57/108 (52%), Gaps = 7/108 (6%) Query: 52 ASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTT 111 A++ N LS++R LLL C V ++ G+TALH+AA ++ + A +L+EA + TT Sbjct: 181 AARYNHLSIIR-LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-----TT 234 Query: 112 CEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159 AGQT L A + N V LLT+ V + G + R+ L Sbjct: 235 IVNNAGQTPLETARYHNNPE-VALLLTKAPQVLRFSRGRSLRKKRERL 281 Score = 51.6 bits (122), Expect = 3e-06 Identities = 37/138 (26%), Positives = 64/138 (46%), Gaps = 18/138 (13%) Query: 63 QLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALH 122 +LL+ +V + G TALH+A + ++ VL+ A + AG T LH Sbjct: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN-----AGDTCLH 179 Query: 123 IAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLL 182 +A +++++R LLT SV + G+ L AA +N +++ ++L Sbjct: 180 VAARYNHLSIIRLLLTAFCSVHEKNQA-------------GDTALHVAAALNHKKVAKIL 226 Query: 183 IEHGADIRAQDSLGNTVL 200 +E GAD ++ G T L Sbjct: 227 LEAGADTTIVNNAGQTPL 244 Score = 46.2 bits (108), Expect = 1e-04 Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 18/124 (14%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G T LH+AA +L +L++A +L + QTALH A V N ++ AL+ Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD-----GDQTALHRATVVGNTEIIAALIH 96 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 G A R ++ G L A+ + +LL++ GA++ A++ GNT Sbjct: 97 E---------GCALDRQDKD----GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNT 143 Query: 199 VLHI 202 LH+ Sbjct: 144 ALHL 147 Score = 45.1 bits (105), Expect = 2e-04 Identities = 48/207 (23%), Positives = 86/207 (41%), Gaps = 30/207 (14%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 ++ L RA+ + ++ L+ + C + ++ G TALH A+ + ++A +L++A + Sbjct: 76 QTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134 Query: 106 VFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH 165 + + AG TALH+A N + R LL + + G+ Sbjct: 135 LAKNK-----AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-------------GDT 176 Query: 166 PLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGH 225 L AA N I+RLL+ + ++ G+T LH+ +K A +LL Sbjct: 177 CLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVA----KILLEAGAD 232 Query: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGN 252 + N+ G TP + A N Sbjct: 233 -------TTIVNNAGQTPLETARYHNN 252 >gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo sapiens] Length = 765 Score = 53.9 bits (128), Expect = 5e-07 Identities = 67/232 (28%), Positives = 100/232 (43%), Gaps = 42/232 (18%) Query: 47 SPLLRASKENDLSVLRQLLLDCTC-DVRQRGALGETALHIAAL--YDNLEAALVLMEAAP 103 +PL A++ D R LL C D ++R G T LH+AA ++N+ LV +A P Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQERE--GWTPLHLAAQNNFENVARLLVSRQADP 487 Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFG 163 L G+T LH+A +V+LV+ L ++ A + A+ RNL Sbjct: 488 NL-------HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ---------RNL---- 527 Query: 164 EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 PL A ++ L++ GA A D G LH + K C+M LL Y Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR-GKYLICKM---LLRY- 582 Query: 224 GHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRH------IQWT 269 G L+ +P HQG TP LA +G+ + L + + + WT Sbjct: 583 --GASLE----LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628 Score = 45.1 bits (105), Expect = 2e-04 Identities = 42/158 (26%), Positives = 68/158 (43%), Gaps = 19/158 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ + L ++ LL + ++ GA+ T LH+AA + L++ + Sbjct: 595 TPLHLAAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD-- 651 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHP 166 P E +G T LH+AV V LL A+V AR G P Sbjct: 652 --PNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHANVHARNK-------------VGWTP 695 Query: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 AA + I+++L+E GA + QD + T L + + Sbjct: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733 Score = 43.5 bits (101), Expect = 7e-04 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 19/162 (11%) Query: 41 QKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100 Q+R +PL A++ N +V R LL+ D A G+T LH+AA + ++ +L Sbjct: 457 QEREGWTPLHLAAQNNFENVAR-LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515 Query: 101 AAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLI 160 EL + +T LH+AV V ++ LL A P L Sbjct: 516 QGAELDAQQRNL-----RTPLHLAVERGKVRAIQHLLKSGA-------------VPDALD 557 Query: 161 YFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 G PL AA I ++L+ +GA + G T LH+ Sbjct: 558 QSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599 Score = 43.1 bits (100), Expect = 0.001 Identities = 56/223 (25%), Positives = 90/223 (40%), Gaps = 34/223 (15%) Query: 41 QKRILESPLLRASKENDLSVLRQLLLD-CTCDVRQRGALGETALHIAALYDNLEAALVLM 99 Q+R L +PL A + + ++ LL D + G LH AA +L+ Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP--LHTAAARGKYLICKMLL 580 Query: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNL 159 L PT G T LH+A ++ ++ L A++ A Sbjct: 581 RYGASLEL-PT----HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGA----------- 624 Query: 160 IYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLL 219 PL AA E +V L++ GAD A + G T LH+ + ++ + NLL Sbjct: 625 --VNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV---QRSTFLSVINLL 679 Query: 220 LSYDGHGD-HLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + H + H + N G TP LA ++GNT + + L++ Sbjct: 680 ---EHHANVHAR------NKVGWTPAHLAALKGNTAILKVLVE 713 Score = 40.0 bits (92), Expect = 0.008 Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 18/122 (14%) Query: 81 TALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR 140 T LH ++E +L+ ++ C+ +G T L IA +Q +L LL Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDV-----DCQTASGYTPLLIAAQDQQPDLCALLLAHG 418 Query: 141 ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200 A + + G PL FAA + RLL++HGA + AQ+ G T L Sbjct: 419 ADAN-------------RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465 Query: 201 HI 202 H+ Sbjct: 466 HL 467 Score = 38.9 bits (89), Expect = 0.017 Identities = 59/202 (29%), Positives = 76/202 (37%), Gaps = 35/202 (17%) Query: 63 QLLLDCTCDVRQRGALGETALHIAAL--YDNLEAALVLMEAAPELVFEPTTCEAFAGQTA 120 +LLL DV + A G T L IAA +L A L+ A V E G Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-------GWAP 431 Query: 121 LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR 180 LH A N + R LL A V A+ G PL AA N E + R Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQERE-------------GWTPLHLAAQNNFENVAR 478 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG 240 LL+ AD ++ G T LH+ + + LL S Q +L + Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGH----VSLVKLLTS--------QGAELDAQQRN 526 Query: 241 L-TPFKLAGVEGNTVMFQHLMQ 261 L TP LA G QHL++ Sbjct: 527 LRTPLHLAVERGKVRAIQHLLK 548 >gi|157743284 ankyrin repeat domain 52 [Homo sapiens] Length = 1076 Score = 53.9 bits (128), Expect = 5e-07 Identities = 63/237 (26%), Positives = 95/237 (40%), Gaps = 43/237 (18%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL RA+ + VL LLL + DV R L +T LH+AA A EA L+ Sbjct: 76 TPLHRAAASRNEKVLG-LLLAHSADVNARDKLWQTPLHVAA----ANRATKCAEALAPLL 130 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYF---- 162 + +G++ALH AV + ++ V LL + AS++ R P + F Sbjct: 131 SSLNVADR-SGRSALHHAVHSGHLETVNLLLNKGASLN---VCDKKERQPLHWAAFLGHL 186 Query: 163 -------------------GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 G L AA E+V+ L+ GA+I ++ GNT LHI Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246 Query: 204 ILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLM 260 A ++ N + + PN +G TP +A V N + L+ Sbjct: 247 CYLGQDAVAIELVNAGANVN-----------QPNDKGFTPLHVAAVSTNGALCLELL 292 Score = 47.8 bits (112), Expect = 4e-05 Identities = 55/216 (25%), Positives = 91/216 (42%), Gaps = 31/216 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 +PL A+ + ++ +LL++ DV + G++ LH+AA++ + +L++ E+ Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI- 332 Query: 107 FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSAR----------ATGTAFRRSP 156 C G T LH+A + L+ L+T A + R A F Sbjct: 333 ----DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388 Query: 157 RNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMY 216 R L+ G+ S + +++E + + G DI D+LG T LH N + Sbjct: 389 RKLLSSGQ-LYSIVSSLSNEHV----LSAGFDINTPDNLGRTCLHAAASGGN----VECL 439 Query: 217 NLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 NLLLS G L+ D G TP A G+ Sbjct: 440 NLLLS---SGADLRRRDKF----GRTPLHYAAANGS 468 Score = 46.6 bits (109), Expect = 8e-05 Identities = 42/139 (30%), Positives = 61/139 (43%), Gaps = 19/139 (13%) Query: 65 LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124 LL ++ + A G TALHIA A+ L+ A V +P G T LH+A Sbjct: 225 LLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN-VNQPND----KGFTPLHVA 279 Query: 125 VVNQNVNLVRALLTRR-ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLI 183 V+ N L LL A V+ ++ G+ PL AA ++LI Sbjct: 280 AVSTNGALCLELLVNNGADVNYQSKE-------------GKSPLHMAAIHGRFTRSQILI 326 Query: 184 EHGADIRAQDSLGNTVLHI 202 ++G++I D GNT LH+ Sbjct: 327 QNGSEIDCADKFGNTPLHV 345 Score = 41.2 bits (95), Expect = 0.003 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 13/85 (15%) Query: 118 QTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEE 177 +T LH A +V +++ LL A+V+A+ T PL AA +E+ Sbjct: 42 RTPLHAAAYVGDVPILQLLLMSGANVNAKDT-------------LWLTPLHRAAASRNEK 88 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHI 202 ++ LL+ H AD+ A+D L T LH+ Sbjct: 89 VLGLLLAHSADVNARDKLWQTPLHV 113 Score = 40.4 bits (93), Expect = 0.006 Identities = 63/270 (23%), Positives = 93/270 (34%), Gaps = 65/270 (24%) Query: 46 ESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPEL 105 E L+ S+ + + LLD D R G TA+H AA Y N + +L+E + Sbjct: 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576 Query: 106 VFEPTT---------------CEAF---------------AGQTALHIAVVNQNVNLVRA 135 + + + CEA G+TAL +A + V Sbjct: 577 LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEV 636 Query: 136 LLTRRASVSAR-----------ATGTAFRRSPRNLI-------------YFGEHPLSFAA 171 L AS + A + S LI +G+ PL A Sbjct: 637 LTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAI 696 Query: 172 CVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQP 231 + V LL+E G+ A D G T LH + T LL +D Sbjct: 697 MNGHVDCVHLLLEKGSTADAADLRGRTALH----RGAVTGCEDCLAALLDHDA------- 745 Query: 232 LDLVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 L + +G TP LA G+T + + L+Q Sbjct: 746 FVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775 Score = 37.0 bits (84), Expect = 0.065 Identities = 44/170 (25%), Positives = 60/170 (35%), Gaps = 41/170 (24%) Query: 72 VRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVN 131 V R A G T LH AA DN+ +L++ E+ T G+TAL A N Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-----GRTALMTAAENGQTA 905 Query: 132 LVRALLTRRASVSARATGTAFRRSPRNLIYFG---------------------------- 163 V LL R +A T + ++ Sbjct: 906 AVEFLLYR-----GKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA 960 Query: 164 -EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 + PL AA +V+ L+ HGA + A D G+T L PNK A Sbjct: 961 LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT--PALACAPNKDVA 1008 Score = 36.6 bits (83), Expect = 0.085 Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 26/165 (15%) Query: 32 HLDKLHML----QQKRILE-------SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGE 80 H D LH+L ++ I + +PL+ A + + LLL+ G Sbjct: 664 HTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH-LLLEKGSTADAADLRGR 722 Query: 81 TALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR 140 TALH A+ + L++ ++ C F G+T +H+A + ++R LL Sbjct: 723 TALHRGAVTGCEDCLAALLDHDAFVL-----CRDFKGRTPIHLASACGHTAVLRTLLQAA 777 Query: 141 ASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH 185 S G + Y G P+ +A+ E+ + LL+EH Sbjct: 778 LSTDPLDAG---------VDYSGYSPMHWASYTGHEDCLELLLEH 813 Score = 36.2 bits (82), Expect = 0.11 Identities = 55/237 (23%), Positives = 89/237 (37%), Gaps = 54/237 (22%) Query: 64 LLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHI 123 LLL D+R+R G T LH AA + + A+ L+ A + C+ G + LH Sbjct: 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV--NEADCK---GCSPLHY 495 Query: 124 AVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLI 183 A + RRA ++ A + PL + + + L+ Sbjct: 496 AAASDTY--------RRAEPHTPSSHDAEE----------DEPLKESRRKEAFFCLEFLL 537 Query: 184 EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL------------------LLSYDGH 225 ++GAD +D G T +H N+ + + L +Y+GH Sbjct: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597 Query: 226 GDHLQPLDL------VPNHQGLTPFKLAGVEGNT----VMFQH---LMQKRRHIQWT 269 + L+ L V +H+G T LA G+T V+ H + K R +WT Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWT 654 Score = 35.8 bits (81), Expect = 0.14 Identities = 40/157 (25%), Positives = 67/157 (42%), Gaps = 20/157 (12%) Query: 47 SPLLRASKENDLSVLRQLLLDC-TCDVRQRGA--LGETALHIAALYDNLEAALVLMEAAP 103 +P+ AS +VLR LL + D G G + +H A+ + + +L+E +P Sbjct: 756 TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815 Query: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFG 163 E T LH AV+N + LL ++ A+ + + G Sbjct: 816 FSYLEGNPF------TPLHCAVINNQDSTTEMLL---GALGAKIVNSRDAK--------G 858 Query: 164 EHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200 PL AA ++ +R+L++H A++ A D G T L Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895 >gi|134244285 Notch homolog 3 [Homo sapiens] Length = 2321 Score = 53.5 bits (127), Expect = 7e-07 Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 23/143 (16%) Query: 64 LLLDCTCDVRQRGA----LGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQT 119 ++ D C Q GA GETALH+AA Y +AA L++A + T + +G+T Sbjct: 1820 IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGAD-----TNAQDHSGRT 1874 Query: 120 ALHIAVVNQNVNLVRALLTRRAS-VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEI 178 LH AV + + L+ R++ + AR G L AA + E + Sbjct: 1875 PLHTAVTADAQGVFQILIRNRSTDLDARMAD-------------GSTALILAARLAVEGM 1921 Query: 179 VRLLIEHGADIRAQDSLGNTVLH 201 V LI AD+ A D LG + LH Sbjct: 1922 VEELIASHADVNAVDELGKSALH 1944 Score = 35.0 bits (79), Expect = 0.25 Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 22/151 (14%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAA--LYDNLEAALVLMEAAPE 104 +PL A + V + L+ + + D+ R A G TAL +AA + + L+ A Sbjct: 1874 TPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVN 1933 Query: 105 LVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGE 164 V E G++ALH A NV ALL A+ + + E Sbjct: 1934 AVDE-------LGKSALHWAAAVNNVEATLALLKNGANKDMQDSKE-------------E 1973 Query: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQDSL 195 PL AA S E +LL++H A+ D L Sbjct: 1974 TPLFLAAREGSYEAAKLLLDHFANREITDHL 2004 Score = 30.8 bits (68), Expect = 4.7 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 12/76 (15%) Query: 129 NVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGAD 188 + +++ L+ + A + AR T GE L AA + + L++ GAD Sbjct: 1817 SASIISDLICQGAQLGARTDRT------------GETALHLAARYARADAAKRLLDAGAD 1864 Query: 189 IRAQDSLGNTVLHILI 204 AQD G T LH + Sbjct: 1865 TNAQDHSGRTPLHTAV 1880 >gi|148833508 notch1 preproprotein [Homo sapiens] Length = 2555 Score = 53.1 bits (126), Expect = 9e-07 Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 30/180 (16%) Query: 74 QRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLV 133 Q GETALH+AA Y +AA L+EA+ + + G+T LH AV + Sbjct: 1923 QTDRTGETALHLAARYSRSDAAKRLLEASADANIQDN-----MGRTPLHAAVSADAQGVF 1977 Query: 134 RALLTRRAS-VSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQ 192 + L+ RA+ + AR ++ G PL AA + E ++ LI AD+ A Sbjct: 1978 QILIRNRATDLDAR-------------MHDGTTPLILAARLAVEGMLEDLINSHADVNAV 2024 Query: 193 DSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGN 252 D LG + LH N A ++L +G +Q N++ TP LA EG+ Sbjct: 2025 DDLGKSALHWAAAVNNVDAA-----VVLLKNGANKDMQ------NNREETPLFLAAREGS 2073 Score = 31.2 bits (69), Expect = 3.6 Identities = 19/54 (35%), Positives = 34/54 (62%), Gaps = 1/54 (1%) Query: 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME 100 +PL+ A++ +L L+ + DV LG++ALH AA +N++AA+VL++ Sbjct: 1997 TPLILAARLAVEGMLEDLI-NSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLK 2049 >gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] Length = 835 Score = 53.1 bits (126), Expect = 9e-07 Identities = 36/124 (29%), Positives = 59/124 (47%), Gaps = 18/124 (14%) Query: 79 GETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLT 138 G TALH+A DN E L+ + ++ + G TALHIA + ++ LL Sbjct: 101 GFTALHLAVYKDNAELITSLLHSGADI-----QQVGYGGLTALHIATIAGHLEAADVLLQ 155 Query: 139 RRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT 198 A+V+ + + ++F PL AA E++ RLL++ GAD+ +G+ Sbjct: 156 HGANVNIQ-----------DAVFFT--PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDR 202 Query: 199 VLHI 202 LH+ Sbjct: 203 PLHL 206 Score = 51.6 bits (122), Expect = 3e-06 Identities = 60/207 (28%), Positives = 84/207 (40%), Gaps = 45/207 (21%) Query: 65 LLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIA 124 LL D++Q G G TALHIA + +LEAA VL++ + + T LHIA Sbjct: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF-----FTPLHIA 174 Query: 125 VVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIE 184 + + R LL A V+ G+ PL A+ I +LL+E Sbjct: 175 AYYGHEQVTRLLLKFGADVNVSGE-------------VGDRPLHLASAKGFLNIAKLLME 221 Query: 185 HG--ADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGD---HLQPLDL----- 234 G AD+ AQD+ + LH C + GH D +L DL Sbjct: 222 EGSKADVNAQDNEDHVPLHF----------CSRF-------GHHDIVKYLLQSDLEVQPH 264 Query: 235 VPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 V N G TP LA G + + ++Q Sbjct: 265 VVNIYGDTPLHLACYNGKFEVAKEIIQ 291 Score = 32.0 bits (71), Expect = 2.1 Identities = 30/142 (21%), Positives = 59/142 (41%), Gaps = 20/142 (14%) Query: 64 LLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHI 123 +LL +V + A+ T LHIAA Y + + +L++ ++ G LH+ Sbjct: 152 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV-----NVSGEVGDRPLHL 206 Query: 124 AVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEH-PLSFAACVNSEEIVRLL 182 A +N+ + L+ + A +H PL F + +IV+ L Sbjct: 207 ASAKGFLNIAKLLMEEGSKADVNAQDNE------------DHVPLHFCSRFGHHDIVKYL 254 Query: 183 IEHGADIRAQ--DSLGNTVLHI 202 ++ +++ + G+T LH+ Sbjct: 255 LQSDLEVQPHVVNIYGDTPLHL 276 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.325 0.139 0.424 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,180,811 Number of Sequences: 37866 Number of extensions: 1116973 Number of successful extensions: 5984 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 171 Number of HSP's successfully gapped in prelim test: 163 Number of HSP's that attempted gapping in prelim test: 3993 Number of HSP's gapped (non-prelim): 1215 length of query: 729 length of database: 18,247,518 effective HSP length: 110 effective length of query: 619 effective length of database: 14,082,258 effective search space: 8716917702 effective search space used: 8716917702 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.