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Search of human proteins with 17318559
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17318559 cyclin E1 isoform 1 [Homo sapiens]
(410 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17318559 cyclin E1 isoform 1 [Homo sapiens] 837 0.0
gi|17318561 cyclin E1 isoform 2 [Homo sapiens] 807 0.0
gi|17318565 cyclin E2 [Homo sapiens] 364 e-101
gi|161377472 cyclin A1 isoform c [Homo sapiens] 105 6e-23
gi|161377470 cyclin A1 isoform c [Homo sapiens] 105 6e-23
gi|161377468 cyclin A1 isoform b [Homo sapiens] 105 6e-23
gi|4502611 cyclin A1 isoform a [Homo sapiens] 105 6e-23
gi|4502613 cyclin A [Homo sapiens] 104 2e-22
gi|14327896 cyclin B1 [Homo sapiens] 100 2e-21
gi|4757930 cyclin B2 [Homo sapiens] 93 4e-19
gi|16950655 cyclin D1 [Homo sapiens] 90 4e-18
gi|4502617 cyclin D2 [Homo sapiens] 80 3e-15
gi|4502619 cyclin D3 isoform 2 [Homo sapiens] 79 7e-15
gi|90669307 cyclin B3 isoform 3 [Homo sapiens] 79 1e-14
gi|5802992 cyclin I [Homo sapiens] 67 4e-11
gi|153791755 cyclin domain containing [Homo sapiens] 63 4e-10
gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Ho... 62 7e-10
gi|16306525 cyclin B3 isoform 1 [Homo sapiens] 54 2e-07
gi|89886237 cyclin I family, member 2 [Homo sapiens] 51 2e-06
gi|4757936 cyclin G2 [Homo sapiens] 49 6e-06
gi|118572588 cyclin F [Homo sapiens] 49 1e-05
gi|197276674 cyclin J isoform 1 [Homo sapiens] 39 0.009
gi|40805832 cyclin G1 [Homo sapiens] 39 0.011
gi|4757934 cyclin G1 [Homo sapiens] 39 0.011
gi|197276676 cyclin J isoform 3 [Homo sapiens] 38 0.019
gi|40254889 cyclin J isoform 2 [Homo sapiens] 38 0.019
gi|27734799 REST corepressor 2 [Homo sapiens] 33 0.47
gi|239757770 PREDICTED: melanoma antigen family B, 5 [Homo sapiens] 32 0.80
gi|169216202 PREDICTED: melanoma antigen family B, 5 [Homo sapiens] 32 0.80
gi|169216811 PREDICTED: melanoma antigen family B, 5 [Homo sapiens] 32 0.80
>gi|17318559 cyclin E1 isoform 1 [Homo sapiens]
Length = 410
Score = 837 bits (2163), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ 60
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
Sbjct: 1 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ 60
Query: 61 PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM 120
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
Sbjct: 61 PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM 120
Query: 121 LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ 180
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
Sbjct: 121 LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ 180
Query: 181 ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR 240
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
Sbjct: 181 ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR 240
Query: 241 LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA 300
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
Sbjct: 241 LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA 300
Query: 301 ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI 360
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
Sbjct: 301 ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI 360
Query: 361 QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 410
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
Sbjct: 361 QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 410
>gi|17318561 cyclin E1 isoform 2 [Homo sapiens]
Length = 395
Score = 807 bits (2085), Expect = 0.0
Identities = 395/395 (100%), Positives = 395/395 (100%)
Query: 16 MKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLI 75
MKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLI
Sbjct: 1 MKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLI 60
Query: 76 PTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLE 135
PTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLE
Sbjct: 61 PTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLE 120
Query: 136 QHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISS 195
QHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISS
Sbjct: 121 QHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISS 180
Query: 196 LFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQ 255
LFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQ
Sbjct: 181 LFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQ 240
Query: 256 VAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQK 315
VAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQK
Sbjct: 241 VAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQK 300
Query: 316 VSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARA 375
VSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARA
Sbjct: 301 VSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARA 360
Query: 376 KKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 410
KKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
Sbjct: 361 KKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA 395
>gi|17318565 cyclin E2 [Homo sapiens]
Length = 404
Score = 364 bits (935), Expect = e-101
Identities = 185/335 (55%), Positives = 235/335 (70%), Gaps = 6/335 (1%)
Query: 71 PCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTY 127
PC +I TP KE D + N K I PS PLP LSW +EVW ML KE Y
Sbjct: 68 PCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKEVWLNMLKKESRY 124
Query: 128 LRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTL 187
+ D+HF H L+P+MR+ILLDWL+EVCEVY LHRETFYLAQDFFDR+M TQ+++ K +
Sbjct: 125 VHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNM 184
Query: 188 LQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIV 247
LQLIGI+SLFIA+KLEEIY PKL +FAYVTDGACS ++IL MEL+I+KALKW L P+TI+
Sbjct: 185 LQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTII 244
Query: 248 SWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHF 307
SWLN+++QV L D +VLLPQY Q+ FIQIA+LLDLC+L +D LEF Y IL A+AL HF
Sbjct: 245 SWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHF 304
Query: 308 SSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSL 367
+S E+++K SG +W I CV WMVPF V++ T KLK F+ + ED HNIQTH + L
Sbjct: 305 TSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTHTNYL 364
Query: 368 DLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKK 402
+L++ + G++TPP+S +K
Sbjct: 365 AMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEK 399
>gi|161377472 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 105 bits (263), Expect = 6e-23
Identities = 52/142 (36%), Positives = 92/142 (64%), Gaps = 1/142 (0%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFF 173
EE+++ + E + H++++ P + MR IL+DWL+EV E YKL ET YLA +F
Sbjct: 169 EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFL 228
Query: 174 DRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI 233
DR+++ +V++ LQL+G +++ +A+K EEIYPP++ +F Y+TD + ++L ME ++
Sbjct: 229 DRFLSCM-SVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 287
Query: 234 MKALKWRLSPLTIVSWLNVYMQ 255
+K L + L+ T +L Y++
Sbjct: 288 LKVLAFDLTVPTTNQFLLQYLR 309
>gi|161377470 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 105 bits (263), Expect = 6e-23
Identities = 52/142 (36%), Positives = 92/142 (64%), Gaps = 1/142 (0%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFF 173
EE+++ + E + H++++ P + MR IL+DWL+EV E YKL ET YLA +F
Sbjct: 169 EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFL 228
Query: 174 DRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI 233
DR+++ +V++ LQL+G +++ +A+K EEIYPP++ +F Y+TD + ++L ME ++
Sbjct: 229 DRFLSCM-SVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 287
Query: 234 MKALKWRLSPLTIVSWLNVYMQ 255
+K L + L+ T +L Y++
Sbjct: 288 LKVLAFDLTVPTTNQFLLQYLR 309
>gi|161377468 cyclin A1 isoform b [Homo sapiens]
Length = 464
Score = 105 bits (263), Expect = 6e-23
Identities = 52/142 (36%), Positives = 92/142 (64%), Gaps = 1/142 (0%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFF 173
EE+++ + E + H++++ P + MR IL+DWL+EV E YKL ET YLA +F
Sbjct: 212 EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFL 271
Query: 174 DRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI 233
DR+++ +V++ LQL+G +++ +A+K EEIYPP++ +F Y+TD + ++L ME ++
Sbjct: 272 DRFLSCM-SVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 330
Query: 234 MKALKWRLSPLTIVSWLNVYMQ 255
+K L + L+ T +L Y++
Sbjct: 331 LKVLAFDLTVPTTNQFLLQYLR 352
>gi|4502611 cyclin A1 isoform a [Homo sapiens]
Length = 465
Score = 105 bits (263), Expect = 6e-23
Identities = 52/142 (36%), Positives = 92/142 (64%), Gaps = 1/142 (0%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFF 173
EE+++ + E + H++++ P + MR IL+DWL+EV E YKL ET YLA +F
Sbjct: 213 EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFL 272
Query: 174 DRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI 233
DR+++ +V++ LQL+G +++ +A+K EEIYPP++ +F Y+TD + ++L ME ++
Sbjct: 273 DRFLSCM-SVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 331
Query: 234 MKALKWRLSPLTIVSWLNVYMQ 255
+K L + L+ T +L Y++
Sbjct: 332 LKVLAFDLTVPTTNQFLLQYLR 353
>gi|4502613 cyclin A [Homo sapiens]
Length = 432
Score = 104 bits (259), Expect = 2e-22
Identities = 64/207 (30%), Positives = 117/207 (56%), Gaps = 29/207 (14%)
Query: 126 TYLRDQH--------FLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYM 177
TYLR+ ++++ P + MRAIL+DWL+EV E YKL ET +LA ++ DR++
Sbjct: 184 TYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFL 243
Query: 178 ATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKAL 237
++ +V++ LQL+G +++ +A+K EEIYPP++ +F Y+TD + ++L ME +++K L
Sbjct: 244 SSM-SVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVL 302
Query: 238 KWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELL--DLCVLDVD-CLEF 294
+ L+ T+ +L Y L Q P ++ + +L ++D D L++
Sbjct: 303 TFDLAAPTVNQFLTQY------------FLHQQPANCKVESLAMFLGELSLIDADPYLKY 350
Query: 295 PYGILAASALYHFSSSELMQKVSGYQW 321
++A +A +H + + V+G W
Sbjct: 351 LPSVIAGAA-FHLA----LYTVTGQSW 372
>gi|14327896 cyclin B1 [Homo sapiens]
Length = 433
Score = 100 bits (249), Expect = 2e-21
Identities = 66/188 (35%), Positives = 107/188 (56%), Gaps = 27/188 (14%)
Query: 127 YLRDQHFLEQHPLLQPK----------MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRY 176
YLR LE+ ++PK MRAIL+DWL++V ++L +ET Y+ DR+
Sbjct: 177 YLRQ---LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRF 233
Query: 177 MATQENVV-KTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMK 235
M Q N V K +LQL+G++++FIA+K EE+YPP++ FA+VTD + +I ME+ I++
Sbjct: 234 M--QNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILR 291
Query: 236 ALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFP 295
AL + L + +L ++ + D+ + L +Y L++L +LD D + FP
Sbjct: 292 ALNFGLGRPLPLHFLRRASKIGEV-DVEQHTLAKY----------LMELTMLDYDMVHFP 340
Query: 296 YGILAASA 303
+AA A
Sbjct: 341 PSQIAAGA 348
>gi|4757930 cyclin B2 [Homo sapiens]
Length = 398
Score = 93.2 bits (230), Expect = 4e-19
Identities = 62/205 (30%), Positives = 111/205 (54%), Gaps = 19/205 (9%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFF 173
+++++ + E + HFL+ + +MRAIL+DWL++V ++L +ET Y+
Sbjct: 136 KDIYQYLRQLEVLQSINPHFLDGRDI-NGRMRAILVDWLVQVHSKFRLLQETLYMCVGIM 194
Query: 174 DRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI 233
DR++ Q V + LQL+GI++L +A+K EE++ P + F Y+TD A + +I ME +I
Sbjct: 195 DRFLQVQP-VSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLI 253
Query: 234 MKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLE 293
+K LK+ L + +L + + D+ + L +Y L++L ++D D +
Sbjct: 254 LKELKFELGRPLPLHFLRRASKAGEV-DVEQHTLAKY----------LMELTLIDYDMVH 302
Query: 294 FPYGILAASALYHFSSSELMQKVSG 318
+ +AA+A S L QKV G
Sbjct: 303 YHPSKVAAAA------SCLSQKVLG 321
>gi|16950655 cyclin D1 [Homo sapiens]
Length = 295
Score = 89.7 bits (221), Expect = 4e-18
Identities = 55/193 (28%), Positives = 103/193 (53%), Gaps = 11/193 (5%)
Query: 114 EEVWKIMLNKEKTYLRDQHFLE--QHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQD 171
+ V + ML E+T + + Q +L P MR I+ W++EVCE K E F LA +
Sbjct: 25 DRVLRAMLKAEETCAPSVSYFKCVQKEVL-PSMRKIVATWMLEVCEEQKCEEEVFPLAMN 83
Query: 172 FFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMEL 231
+ DR+++ E V K+ LQL+G + +F+A+K++E P + TD + +E+L MEL
Sbjct: 84 YLDRFLSL-EPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMEL 142
Query: 232 MIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDC 291
+++ LKW L+ +T ++ ++ + ++ ++ ++ Q + LC DV
Sbjct: 143 LLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQ-------TFVALCATDVKF 195
Query: 292 LEFPYGILAASAL 304
+ P ++AA ++
Sbjct: 196 ISNPPSMVAAGSV 208
>gi|4502617 cyclin D2 [Homo sapiens]
Length = 289
Score = 80.1 bits (196), Expect = 3e-15
Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 21/198 (10%)
Query: 114 EEVWKIMLNKEKTYLRD-QHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDF 172
+ V + +L E+ YL +F +QP MR ++ W++EVCE K E F LA ++
Sbjct: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
Query: 173 FDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELM 232
DR++A K+ LQL+G +F+A+KL+E P + TD + E+L EL+
Sbjct: 84 LDRFLAGVPTP-KSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELV 142
Query: 233 IMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQ------IFIQIAELLDLCV 286
++ LKW L+ +T +D E +L + PQQ I + LC
Sbjct: 143 VLGKLKWNLAAVT-------------PHDFIEHILRKLPQQREKLSLIRKHAQTFIALCA 189
Query: 287 LDVDCLEFPYGILAASAL 304
D +P ++A ++
Sbjct: 190 TDFKFAMYPPSMIATGSV 207
>gi|4502619 cyclin D3 isoform 2 [Homo sapiens]
Length = 292
Score = 79.0 bits (193), Expect = 7e-15
Identities = 55/193 (28%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 114 EEVWKIMLNKEKTYL-RDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDF 172
+ V + +L E+ Y+ R +F ++P MR +L W++EVCE + E F LA ++
Sbjct: 25 QRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNY 84
Query: 173 FDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELM 232
DRY++ K LQL+G + +A+KL E P + + TD A S ++ E++
Sbjct: 85 LDRYLSCVP-TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVL 143
Query: 233 IMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAE-LLDLCVLDVDC 291
++ LKW L+ + +L A++ LH + LP+ Q + + A+ L LC D
Sbjct: 144 VLGKLKWDLAAVIAHDFL------AFI--LHRLSLPRDRQALVKKHAQTFLALCATDYTF 195
Query: 292 LEFPYGILAASAL 304
+P ++A ++
Sbjct: 196 AMYPPSMIATGSI 208
>gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
Length = 1395
Score = 78.6 bits (192), Expect = 1e-14
Identities = 57/203 (28%), Positives = 98/203 (48%), Gaps = 7/203 (3%)
Query: 79 DKEDDDRVYPNSTCKPRIIAP----SRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFL 134
+ D V P + P+ I P S P + +E++ M +E+ ++ +
Sbjct: 1092 ESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMN 1151
Query: 135 EQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGIS 194
Q + MRAIL+DWL+EV +++ ET YLA D Y+ + K LQL+G +
Sbjct: 1152 RQIEITSD-MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLGAT 1209
Query: 195 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM 254
+ IAAK EE P++ F Y+ D E+L+ME+ I+ LK ++ +L Y
Sbjct: 1210 AFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYA 1269
Query: 255 QVAYLNDLHEVLLPQYPQQIFIQ 277
+ + N + + L +Y ++ +Q
Sbjct: 1270 RCIHTN-MKTLTLSRYICEMTLQ 1291
>gi|5802992 cyclin I [Homo sapiens]
Length = 377
Score = 66.6 bits (161), Expect = 4e-11
Identities = 71/260 (27%), Positives = 120/260 (46%), Gaps = 33/260 (12%)
Query: 115 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFD 174
++WK+ + K + + + P R ++ WL ++ + L+ ETF LA D
Sbjct: 25 QMWKVNVRK----------MPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLD 74
Query: 175 RYMATQENVVKTLLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACSGDEILTMELM 232
R++AT + K L I IS F+AAK E+ P L A + CS EIL ME +
Sbjct: 75 RFLATVKAHPK-YLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERI 133
Query: 233 IMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVL--LPQY-PQQIFIQIAELLDLCVLDV 289
I+ L W L T + +L+++ +A ++ ++L LP+ P Q + + L C+
Sbjct: 134 ILDKLNWDLHTATPLDFLHIFHAIA-VSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACN 192
Query: 290 DCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHF 349
L+F +LA + + S E+ + + + IE K + SS+L H
Sbjct: 193 QLLQFRGSMLALAMV----SLEMEKLIPDWLSLTIELLQK---------AQMDSSQLIHC 239
Query: 350 RGVADEDAHNIQTHRDSLDL 369
R + AH++ T + SL L
Sbjct: 240 RELV---AHHLSTLQSSLPL 256
>gi|153791755 cyclin domain containing [Homo sapiens]
Length = 350
Score = 63.2 bits (152), Expect = 4e-10
Identities = 52/193 (26%), Positives = 85/193 (44%), Gaps = 27/193 (13%)
Query: 72 CSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTY---- 127
C L +P D P+ A GSPLP + V ++ L + Y
Sbjct: 58 CDLFESPSSGSDGAESPS--------AARGGSPLP----GPAQPVAQLDLQTFRDYGQSC 105
Query: 128 -----LRDQHF-----LEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYM 177
++ HF L + P + + R LL WL+ V + L E+ L + DR++
Sbjct: 106 YAFRKAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFL 165
Query: 178 ATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKAL 237
T V QL+G++SL IA K E++PP++ Q + GA S ++ +E +++ L
Sbjct: 166 TTTP-VAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKL 224
Query: 238 KWRLSPLTIVSWL 250
+ L TI +L
Sbjct: 225 HFTLGAPTISFFL 237
>gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Homo
sapiens]
Length = 307
Score = 62.4 bits (150), Expect = 7e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 18/166 (10%)
Query: 142 PKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAK 201
P+MRA+++DWL++V E L +T YLA D Y++ V LQL+G++ LF+A K
Sbjct: 105 PEMRALVVDWLVQVHEYLGLAGDTLYLAVHLLDSYLSA-GRVRLHRLQLLGVACLFVACK 163
Query: 202 LEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRL---SPLTIVSWLNVYMQVAY 258
+EE P+ ++ + S E+L E I+ L +RL PL + L
Sbjct: 164 MEECVLPEPAFLCLLSADSFSRAELLRAERRILSRLDFRLHHPGPLLCLGLL-------- 215
Query: 259 LNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASAL 304
L Q+ + L+L +L+ + + G AA+AL
Sbjct: 216 ------AALAGSSPQVMLLATYFLELSLLEAEAAGWEPGRRAAAAL 255
>gi|16306525 cyclin B3 isoform 1 [Homo sapiens]
Length = 291
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/119 (29%), Positives = 61/119 (51%), Gaps = 2/119 (1%)
Query: 159 YKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTD 218
+++ ET YLA D Y+ + K LQL+G ++ IAAK EE P++ F Y+ D
Sbjct: 71 FEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICD 129
Query: 219 GACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQ 277
E+L+ME+ I+ LK ++ +L Y + + N + + L +Y ++ +Q
Sbjct: 130 DNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTN-MKTLTLSRYICEMTLQ 187
>gi|89886237 cyclin I family, member 2 [Homo sapiens]
Length = 369
Score = 50.8 bits (120), Expect = 2e-06
Identities = 49/176 (27%), Positives = 82/176 (46%), Gaps = 11/176 (6%)
Query: 151 WLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKL--EEIYPP 208
WL+ + + + TF LA F R + + + V + L I+SL +AAK+ EE + P
Sbjct: 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVK-VKEKYLHCATITSLRLAAKVNEEEEFIP 214
Query: 209 KLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEV-LL 267
++ F S +E+L MEL I+ L W L T + +L ++ + L+ H + LL
Sbjct: 215 QVKDFTKHYGSDYSPNELLRMELAILDRLHWDLYIGTPLDFLTIFHALVVLSWPHVLELL 274
Query: 268 PQYPQQIFI-QIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWC 322
PQ + + + L C+ L+F LA + + EL + + G WC
Sbjct: 275 PQRNPSLHVASLTRQLQHCMAGHQLLQFKGSTLALVII----TLELERLMPG--WC 324
>gi|4757936 cyclin G2 [Homo sapiens]
Length = 344
Score = 49.3 bits (116), Expect = 6e-06
Identities = 33/121 (27%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 135 EQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGIS 194
E L P +R ++ L + + ETF LA + DR++A + V L IG+
Sbjct: 46 ENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMK-VKPKHLSCIGVC 104
Query: 195 SLFIAAKL--EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNV 252
S +AA++ E+ P H ++ C+ +I ME +I + L + L T +++L++
Sbjct: 105 SFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHL 164
Query: 253 Y 253
Y
Sbjct: 165 Y 165
>gi|118572588 cyclin F [Homo sapiens]
Length = 786
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/167 (26%), Positives = 76/167 (45%), Gaps = 16/167 (9%)
Query: 140 LQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIA 199
L MR IL+DWL+EV + +L + DRY+ + V + LQL+GI+ + I
Sbjct: 305 LNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYL-RRRLVPRYRLQLLGIACMVIC 363
Query: 200 AKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYL 259
+ + + ++TD ++++ M I+ AL+ ++ T+V
Sbjct: 364 TRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVV------------ 411
Query: 260 NDLHEVLLPQYPQQIFIQ--IAELLDLCVLDVDCLEFPYGILAASAL 304
D EVLL P ++ Q + L +L +L + LAA+AL
Sbjct: 412 -DYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAAL 457
>gi|197276674 cyclin J isoform 1 [Homo sapiens]
Length = 383
Score = 38.9 bits (89), Expect = 0.009
Identities = 40/186 (21%), Positives = 81/186 (43%), Gaps = 31/186 (16%)
Query: 167 YLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQFAYV-----TDG 219
YL F DRY + + L L+ +S L +A+K EE PKL Q + +
Sbjct: 66 YLLDLFMDRYDISIQQ-----LHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNL 120
Query: 220 ACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM-QVAYLNDLHE----VLLPQYPQQI 274
+ +L MEL++++ +W L T ++ Y+ + + DLH+ + L + +
Sbjct: 121 VLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMICLEKTKLYM 180
Query: 275 FIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSEL-----------MQKVSGYQWCD 323
L++ + D L + ++AA+ + +SS + + +++ Y W
Sbjct: 181 AKYADYFLEVSLQDYAFLNYAPSLVAAACV---ASSRIILRLSPTWPTRLHRLTAYSWDF 237
Query: 324 IENCVK 329
+ C++
Sbjct: 238 LVQCIE 243
>gi|40805832 cyclin G1 [Homo sapiens]
Length = 295
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/124 (22%), Positives = 59/124 (47%), Gaps = 7/124 (5%)
Query: 143 KMRAILLDW----LMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFI 198
+M A L D+ L+ + + + ETF LA + DR+++ + V L +G+S ++
Sbjct: 46 RMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMK-VQPKHLGCVGLSCFYL 104
Query: 199 AAKL--EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQV 256
A K EE P ++ + +++ ME ++++ + W++ T +L +Y +
Sbjct: 105 AVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSL 164
Query: 257 AYLN 260
N
Sbjct: 165 LQEN 168
>gi|4757934 cyclin G1 [Homo sapiens]
Length = 295
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/124 (22%), Positives = 59/124 (47%), Gaps = 7/124 (5%)
Query: 143 KMRAILLDW----LMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFI 198
+M A L D+ L+ + + + ETF LA + DR+++ + V L +G+S ++
Sbjct: 46 RMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMK-VQPKHLGCVGLSCFYL 104
Query: 199 AAKL--EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQV 256
A K EE P ++ + +++ ME ++++ + W++ T +L +Y +
Sbjct: 105 AVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSL 164
Query: 257 AYLN 260
N
Sbjct: 165 LQEN 168
>gi|197276676 cyclin J isoform 3 [Homo sapiens]
Length = 371
Score = 37.7 bits (86), Expect = 0.019
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 13/106 (12%)
Query: 167 YLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQFAYV-----TDG 219
YL F DRY + + L L+ +S L +A+K EE PKL Q + +
Sbjct: 66 YLLDLFMDRYDISIQQ-----LHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNL 120
Query: 220 ACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM-QVAYLNDLHE 264
+ +L MEL++++ +W L T ++ Y+ + + DLH+
Sbjct: 121 VLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHD 166
>gi|40254889 cyclin J isoform 2 [Homo sapiens]
Length = 372
Score = 37.7 bits (86), Expect = 0.019
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 13/106 (12%)
Query: 167 YLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYP--PKLHQFAYV-----TDG 219
YL F DRY + + L L+ +S L +A+K EE PKL Q + +
Sbjct: 66 YLLDLFMDRYDISIQQ-----LHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNL 120
Query: 220 ACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM-QVAYLNDLHE 264
+ +L MEL++++ +W L T ++ Y+ + + DLH+
Sbjct: 121 VLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHD 166
>gi|27734799 REST corepressor 2 [Homo sapiens]
Length = 523
Score = 33.1 bits (74), Expect = 0.47
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 75 IPTPDKEDDDRVYPNS--TCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQH 132
+P P E+DD V S T PR + P+ P P S + + + L T LR
Sbjct: 409 LPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPP 468
Query: 133 FLEQHPLLQPKM 144
L+Q LQP++
Sbjct: 469 PLQQGRFLQPRL 480
>gi|239757770 PREDICTED: melanoma antigen family B, 5 [Homo
sapiens]
Length = 367
Score = 32.3 bits (72), Expect = 0.80
Identities = 13/25 (52%), Positives = 14/25 (56%)
Query: 52 TARDQCGSQPWDNNAVCADPCSLIP 76
T C SQPWDN C DP +L P
Sbjct: 5 TTEFNCYSQPWDNEDRCTDPLNLPP 29
>gi|169216202 PREDICTED: melanoma antigen family B, 5 [Homo
sapiens]
Length = 367
Score = 32.3 bits (72), Expect = 0.80
Identities = 13/25 (52%), Positives = 14/25 (56%)
Query: 52 TARDQCGSQPWDNNAVCADPCSLIP 76
T C SQPWDN C DP +L P
Sbjct: 5 TTEFNCYSQPWDNEDRCTDPLNLPP 29
>gi|169216811 PREDICTED: melanoma antigen family B, 5 [Homo
sapiens]
Length = 367
Score = 32.3 bits (72), Expect = 0.80
Identities = 13/25 (52%), Positives = 14/25 (56%)
Query: 52 TARDQCGSQPWDNNAVCADPCSLIP 76
T C SQPWDN C DP +L P
Sbjct: 5 TTEFNCYSQPWDNEDRCTDPLNLPP 29
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,661,657
Number of Sequences: 37866
Number of extensions: 763709
Number of successful extensions: 2311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2267
Number of HSP's gapped (non-prelim): 40
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.