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Search of human proteins with 171906567
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171906567 peripheral benzodiazepine receptor-associated
protein 1 isoform b [Homo sapiens]
(1797 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171906567 peripheral benzodiazepine receptor-associated prote... 3643 0.0
gi|171906559 peripheral benzodiazepine receptor-associated prote... 3599 0.0
gi|140561070 RIM-binding protein 2 [Homo sapiens] 425 e-118
gi|191252814 RIMS binding protein 3B [Homo sapiens] 270 7e-72
gi|191252806 RIMS binding protein 3C [Homo sapiens] 269 2e-71
gi|153792195 DKFZP434H0735 protein [Homo sapiens] 268 3e-71
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi... 81 8e-15
gi|148746195 trichohyalin [Homo sapiens] 80 1e-14
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 72 4e-12
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 72 5e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 72 6e-12
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 71 1e-11
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 70 2e-11
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 70 2e-11
gi|221139761 zinc finger protein 853 [Homo sapiens] 69 4e-11
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 69 4e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 69 4e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 69 4e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 69 4e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 69 4e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 69 5e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 68 9e-11
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 68 9e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 67 1e-10
gi|45439327 periplakin [Homo sapiens] 67 1e-10
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 67 2e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 67 2e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 67 2e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 67 2e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 67 2e-10
>gi|171906567 peripheral benzodiazepine receptor-associated protein 1
isoform b [Homo sapiens]
Length = 1797
Score = 3643 bits (9448), Expect = 0.0
Identities = 1797/1797 (100%), Positives = 1797/1797 (100%)
Query: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES
Sbjct: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
Query: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD
Sbjct: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA
Sbjct: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
Query: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 240
RKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL
Sbjct: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 240
Query: 241 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 300
QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK
Sbjct: 241 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 300
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 360
KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA
Sbjct: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 360
Query: 361 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ
Sbjct: 361 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
Query: 421 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 480
REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD
Sbjct: 421 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 480
Query: 481 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 540
CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK
Sbjct: 481 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 540
Query: 541 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 600
AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA
Sbjct: 541 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 600
Query: 601 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 660
RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD
Sbjct: 601 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 660
Query: 661 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 720
DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP
Sbjct: 661 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 720
Query: 721 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 780
SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP
Sbjct: 721 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 780
Query: 781 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 840
PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI
Sbjct: 781 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 840
Query: 841 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 900
TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE
Sbjct: 841 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 900
Query: 901 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 960
RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA
Sbjct: 901 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 960
Query: 961 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1020
IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP
Sbjct: 961 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1020
Query: 1021 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1080
ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA
Sbjct: 1021 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1080
Query: 1081 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1140
KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP
Sbjct: 1081 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1140
Query: 1141 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1200
ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI
Sbjct: 1141 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1200
Query: 1201 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1260
QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP
Sbjct: 1201 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1260
Query: 1261 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1320
LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC
Sbjct: 1261 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1320
Query: 1321 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1380
PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS
Sbjct: 1321 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1380
Query: 1381 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1440
GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE
Sbjct: 1381 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1440
Query: 1441 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1500
YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP
Sbjct: 1441 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1500
Query: 1501 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1560
ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL
Sbjct: 1501 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1560
Query: 1561 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1620
AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT
Sbjct: 1561 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1620
Query: 1621 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1680
GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK
Sbjct: 1621 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1680
Query: 1681 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1740
KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV
Sbjct: 1681 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1740
Query: 1741 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1797
FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC
Sbjct: 1741 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1797
>gi|171906559 peripheral benzodiazepine receptor-associated protein 1
isoform a [Homo sapiens]
Length = 1857
Score = 3599 bits (9332), Expect = 0.0
Identities = 1791/1857 (96%), Positives = 1792/1857 (96%), Gaps = 60/1857 (3%)
Query: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES
Sbjct: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
Query: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD
Sbjct: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEER- 179
RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEER
Sbjct: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
Query: 180 ---------------------------------ARKLQETNLRV---------------- 190
AR L ET +
Sbjct: 181 RKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
Query: 191 ----------EGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 240
EGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL
Sbjct: 241 LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 300
Query: 241 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 300
QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK
Sbjct: 301 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 360
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 360
KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA
Sbjct: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 420
Query: 361 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ
Sbjct: 421 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 480
Query: 421 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 480
REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD
Sbjct: 481 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 540
Query: 481 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 540
CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK
Sbjct: 541 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 600
Query: 541 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 600
AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA
Sbjct: 601 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 660
Query: 601 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 660
RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD
Sbjct: 661 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 720
Query: 661 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 720
DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP
Sbjct: 721 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 780
Query: 721 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 780
SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP
Sbjct: 781 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 840
Query: 781 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 840
PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI
Sbjct: 841 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 900
Query: 841 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 900
TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE
Sbjct: 901 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 960
Query: 901 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 960
RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA
Sbjct: 961 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 1020
Query: 961 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1020
IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP
Sbjct: 1021 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1080
Query: 1021 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1080
ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA
Sbjct: 1081 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1140
Query: 1081 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1140
KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP
Sbjct: 1141 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1200
Query: 1141 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1200
ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI
Sbjct: 1201 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1260
Query: 1201 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1260
QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP
Sbjct: 1261 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1320
Query: 1261 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1320
LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC
Sbjct: 1321 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1380
Query: 1321 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1380
PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS
Sbjct: 1381 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1440
Query: 1381 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1440
GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE
Sbjct: 1441 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1500
Query: 1441 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1500
YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP
Sbjct: 1501 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1560
Query: 1501 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1560
ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL
Sbjct: 1561 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1620
Query: 1561 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1620
AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT
Sbjct: 1621 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1680
Query: 1621 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1680
GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK
Sbjct: 1681 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1740
Query: 1681 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1740
KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV
Sbjct: 1741 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1800
Query: 1741 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1797
FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC
Sbjct: 1801 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1857
>gi|140561070 RIM-binding protein 2 [Homo sapiens]
Length = 1052
Score = 425 bits (1093), Expect = e-118
Identities = 301/865 (34%), Positives = 438/865 (50%), Gaps = 116/865 (13%)
Query: 381 MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQAR 440
MRE A+RRQQL++EH+QA L KQ+E+ LQ +++
Sbjct: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQ------------------------KSK 36
Query: 441 VRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPC 500
VRELEE+CR+Q+EQF+LL+++L+ FR H G +DLL +
Sbjct: 37 VRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGS---------------------- 74
Query: 501 RGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESL--SNSSHSESIHNSPK 558
P D+ P S+P P + G+ K ES +S+ E I P+
Sbjct: 75 -AVAPLDISTAP----------SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQ 123
Query: 559 SCPTPEVDTA---------SEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEG 609
PE +A S E+D + + R ++ + +ARYSYNPF+G
Sbjct: 124 PGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDG 183
Query: 610 PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPP 669
PNENPEAELPLTAG+Y+Y+YG+MDEDGF+EGEL+DG+RGLVPSNFV+ V D++
Sbjct: 184 PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNE------- 236
Query: 670 ELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDEL--SLSPSPEGLGE 727
+ L+ + G E + G G+ + P + D +L + + +GE
Sbjct: 237 --SRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGE 294
Query: 728 PPAVPYPRRLVVLKQLAHSVVLAWEP---PPEQVELHGFHICVNGELRQALGPGAPPKAV 784
VPYPR++ ++KQLA SV++ WEP PP + +++ V+ E R L G+ KA+
Sbjct: 295 -DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKAL 353
Query: 785 LENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVP 844
+E L++ A ISVQ +TSRGSSD L+C L VG V PS LRV +T SA+++W+P
Sbjct: 354 IEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLP 413
Query: 845 GNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQ 904
NSN +H I+LN EE + Y F +LRP Y+ +V A+ P Q PW+ E+ E+
Sbjct: 414 TNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-PHQMPWQLPLEQREK 472
Query: 905 RAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYAD 964
+ A ++F+TLPAGPP P DV ++ G +P + +SW P + G SNG VTGY +YA
Sbjct: 473 KEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAK 532
Query: 965 GQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLP 1024
GQ++ EV PTA S VEL +L+ L+ + V VRT+S GES DS A + P L
Sbjct: 533 GQRVAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAVPPEL------ 585
Query: 1025 ARVSCPSPHPSPEARA-PLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGS 1083
+ P+PHP P ++ PLAS+ G P + +H P + +P G
Sbjct: 586 --LVPPTPHPRPAPQSKPLASS----GVPETKDEHLGPHARMDEAWEQSRAPG--PVHGH 637
Query: 1084 HEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASS 1143
+PP + + + + T ++T+ + AA +A+ SS
Sbjct: 638 MLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSS 697
Query: 1144 STQGARAQQAPNTEMCQGGDPGSGLRPRAEKED---TAELG-----VHLVNSLVDHGRNS 1195
+ Q A + + D R A +D +ELG H + R S
Sbjct: 698 AGQYAASDEE------DAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGDEYHTESSRGS 751
Query: 1196 DLSDIQEEEEEE--EEEEEEELGSR 1218
DLSDI EE+EEE E + E+ G R
Sbjct: 752 DLSDIMEEDEEELYSEMQLEDGGRR 776
Score = 207 bits (526), Expect = 1e-52
Identities = 127/275 (46%), Positives = 157/275 (57%), Gaps = 47/275 (17%)
Query: 1505 RSATGRAKEPLSRATETGEARGQDGSGRRGPQ-KRGVRVLRPSTAELVP-----ARSP-- 1556
R +G + L A D GRR P+ G + RP T + SP
Sbjct: 776 RRPSGTSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDF 835
Query: 1557 ---SET-LAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFY 1612
SET + LP RIFVALFDYDP++MSPNPDA EEELPF+EGQI+KV+GDKDADGFY
Sbjct: 836 YEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFY 895
Query: 1613 QGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGP 1672
+GE R G IPCNMV+E+ D QLL++G+L + +E
Sbjct: 896 RGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVE----------------K 939
Query: 1673 PPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPF 1732
+ RRS + S + MVA +DY+P+ESSPN+DVEAEL F
Sbjct: 940 IERSRRSGRRHS-------------------VSTRRMVALYDYDPRESSPNVDVEAELTF 980
Query: 1733 RAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLE 1767
GD+ITVFG +D+DGFYYGELNGQ+GLVPSNFLE
Sbjct: 981 CTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
Score = 70.9 bits (172), Expect = 1e-11
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 1707 HSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGE-LNGQRGLVPSNF 1765
H VA + YNP + PN + EAELP AG + V+G MD+DGFY GE L+GQRGLVPSNF
Sbjct: 170 HLCVARYSYNPFDG-PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNF 228
Query: 1766 LE 1767
++
Sbjct: 229 VD 230
Score = 69.3 bits (168), Expect = 3e-11
Identities = 36/75 (48%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 588 GSRGGARIQVFLARYSYNPFEG-PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGR 646
G R + +A Y Y+P E PN + EAEL G+ I ++G +DEDGF+ GEL +G+
Sbjct: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQ 1005
Query: 647 RGLVPSNFVERVSDD 661
+GLVPSNF+E V DD
Sbjct: 1006 KGLVPSNFLEEVPDD 1020
Score = 66.6 bits (161), Expect = 2e-10
Identities = 35/67 (52%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627
R VAL+DYDP SPN D E EL F G I+ VFG+ D DGFY GE G+ G +P N
Sbjct: 955 RRMVALYDYDPRESSPNVDV-EAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF 1013
Query: 1628 VAEVAVD 1634
+ EV D
Sbjct: 1014 LEEVPDD 1020
Score = 54.3 bits (129), Expect = 1e-06
Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 596 QVFLARYSYNPFE-GPNENP-EAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSN 653
++F+A + Y+P PN + E ELP G+ I +YG+ D DGF+ GE R GL+P N
Sbjct: 851 RIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC-ARLGLIPCN 909
Query: 654 FVERVSDDD 662
V + DD
Sbjct: 910 MVSEIQADD 918
Score = 48.9 bits (115), Expect = 4e-05
Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 1567 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPC 1625
V + VA + Y+P PN + E ELP G+ L V+GD D DGFY+GE G+ G +P
Sbjct: 169 VHLCVARYSYNPFD-GPNENP-EAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPS 226
Query: 1626 NMV 1628
N V
Sbjct: 227 NFV 229
>gi|191252814 RIMS binding protein 3B [Homo sapiens]
Length = 1639
Score = 270 bits (691), Expect = 7e-72
Identities = 329/1147 (28%), Positives = 472/1147 (41%), Gaps = 278/1147 (24%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVI-------AK 174
N L +AL L +RC L+EEN+ LR++ P + +EKV+RLK K AEL + A+
Sbjct: 377 NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 175 RLEE---------------------------RARKLQET------------NLRVE---- 191
L+E RAR L E LR E
Sbjct: 437 ELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLL 496
Query: 192 -----------------GP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 232
GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 497 QARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ---------- 546
Query: 233 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292
Q GA P A G++ E E +++ LE EL ++R++C+
Sbjct: 547 --------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRRECQ 585
Query: 293 SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG 352
L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 586 ELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
Query: 353 VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++ L
Sbjct: 646 ACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQAL 695
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LHP 469
Q + Q+ ES + R + R + S +++Q R L
Sbjct: 696 QCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
Query: 470 GPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPAT 529
P+ L SA S+PQ SE PA+
Sbjct: 752 SPVALGESA----------------SVPQV-----------------------SETVPAS 772
Query: 530 LTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPEG 588
+ +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 773 -----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSA 827
Query: 589 SRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRG 648
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRRG
Sbjct: 828 APAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
Query: 649 LVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPE 708
LVPSNFVE++ D + LP + DL G S + Q
Sbjct: 888 LVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEAL 926
Query: 709 EEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVN 768
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 927 EEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQL 970
Query: 769 GELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQ 827
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 971 G-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYLD 1027
Query: 828 LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA 887
R H LT G H P YW T + V
Sbjct: 1028 DREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVTF 1078
Query: 888 QLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVT 944
GP P E L +R A+ L + LP A G S G+ + +
Sbjct: 1079 DTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY---- 1126
Query: 945 IDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHG 1004
A ++G++V A G ++ E SQLQ+ ++V VRTMS G
Sbjct: 1127 ---AVYADGLKVCEVADATAGSTVL------------EFSQLQVPLTWQKVSVRTMSLCG 1171
Query: 1005 ESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHP 1059
ES DS+PA I P + P +C GDPS+ +
Sbjct: 1172 ESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRVT 1210
Query: 1060 APLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD- 1118
P+ Q+ APP++ + GS +P A + A R + S LG +
Sbjct: 1211 FPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEGE 1265
Query: 1119 -PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDT 1177
P A S A++ AE A E C Q + P + Q G+ + + +
Sbjct: 1266 CPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSP 1323
Query: 1178 AELGVHL 1184
A +HL
Sbjct: 1324 APGFIHL 1330
Score = 127 bits (319), Expect = 1e-28
Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)
Query: 1517 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1562
R TE E R + R Q KRG ++ PS+A L PA S P +
Sbjct: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
Query: 1563 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1622
+ P R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G
Sbjct: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
Query: 1623 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1682
IP +VAE+ V G +Q R + SP G+ P V G
Sbjct: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LT 1550
Query: 1683 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1742
+G + G K +P L P M+AA DY+P + + L RAGDV+ V+G
Sbjct: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
Query: 1743 GMDDDGFYYGELNGQRGLVPSNFLE 1767
MDD GFYYGEL G RGLVP++ L+
Sbjct: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1710 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1767
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
Score = 58.2 bits (139), Expect = 7e-08
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1480 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1522
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1523 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1574
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1575 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1631
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
Query: 1632 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1660
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 4e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 596 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 654
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 655 VERVS 659
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 236 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 295
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 296 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 354
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 355 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 414
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 415 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 474
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 475 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 528
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 529 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 584
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 585 APEGSRGGAR 594
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1628 VAEVAV 1633
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 37.4 bits (85), Expect = 0.13
Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)
Query: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 288
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 289 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 344
++C +L++E ++ +R C + + ++++ + + A L RL+ RA E ++ +A
Sbjct: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
Query: 345 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 401
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 402 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 435
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 436 SMQARVRELEEQCRSQTE 453
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|191252806 RIMS binding protein 3C [Homo sapiens]
Length = 1639
Score = 269 bits (688), Expect = 2e-71
Identities = 328/1147 (28%), Positives = 472/1147 (41%), Gaps = 278/1147 (24%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVI-------AK 174
N L +AL L +RC L+EEN+ LR++ P + +EKV+RLK K AEL + A+
Sbjct: 377 NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 175 RLEE---------------------------RARKLQET------------NLRVE---- 191
L+E RAR L E LR E
Sbjct: 437 ELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLL 496
Query: 192 -----------------GP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 232
GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 497 QARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ---------- 546
Query: 233 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292
Q GA P A G++ E E +++ LE EL ++R++C+
Sbjct: 547 --------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRRECQ 585
Query: 293 SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG 352
L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 586 ELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
Query: 353 VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++ L
Sbjct: 646 ACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQAL 695
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LHP 469
Q + Q+ ES + R + R + S +++Q R L
Sbjct: 696 QCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
Query: 470 GPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPAT 529
P+ L SA S+PQ SE PA+
Sbjct: 752 SPVALGESA----------------SVPQV-----------------------SETVPAS 772
Query: 530 LTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPEG 588
+ +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 773 -----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSA 827
Query: 589 SRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRG 648
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRRG
Sbjct: 828 APAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
Query: 649 LVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPE 708
LVPSNFVE++ D + LP + DL G S + Q
Sbjct: 888 LVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEAL 926
Query: 709 EEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVN 768
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 927 EEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQL 970
Query: 769 GELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQ 827
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 971 G-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYLD 1027
Query: 828 LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA 887
R H LT G H P YW T + V
Sbjct: 1028 DREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVTF 1078
Query: 888 QLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVT 944
GP P + L +R A+ L + LP A G S G+ + +
Sbjct: 1079 DTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY---- 1126
Query: 945 IDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHG 1004
A ++G++V A G ++E SQLQ+ ++V VRTMS G
Sbjct: 1127 ---AVYADGLKVCEVADATAGSTVLE------------FSQLQVPLTWQKVSVRTMSLCG 1171
Query: 1005 ESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHP 1059
ES DS+PA I P + P +C GDPS+ +
Sbjct: 1172 ESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRVT 1210
Query: 1060 APLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD- 1118
P+ Q+ APP++ + GS +P A + A R + S LG +
Sbjct: 1211 FPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEGE 1265
Query: 1119 -PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDT 1177
P A S A++ AE A E C Q + P + Q G+ + + +
Sbjct: 1266 CPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSP 1323
Query: 1178 AELGVHL 1184
A +HL
Sbjct: 1324 APGFIHL 1330
Score = 127 bits (318), Expect = 1e-28
Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)
Query: 1517 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1562
R TE E R + R Q KRG ++ PS+A L PA S P +
Sbjct: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
Query: 1563 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1622
+ P R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G
Sbjct: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
Query: 1623 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1682
IP +VAE+ V G +Q R + SP G+ P V G
Sbjct: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LI 1550
Query: 1683 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1742
+G + G K +P L P M+AA DY+P + + L RAGDV+ V+G
Sbjct: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
Query: 1743 GMDDDGFYYGELNGQRGLVPSNFLE 1767
MDD GFYYGEL G RGLVP++ L+
Sbjct: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1710 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1767
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
Score = 58.2 bits (139), Expect = 7e-08
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1480 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1522
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1523 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1574
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1575 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1631
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
Query: 1632 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1660
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 4e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 596 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 654
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 655 VERVS 659
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 236 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 295
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 296 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 354
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 355 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 414
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 415 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 474
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 475 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 528
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 529 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 584
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 585 APEGSRGGAR 594
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1628 VAEVAV 1633
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 37.4 bits (85), Expect = 0.13
Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)
Query: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 288
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 289 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 344
++C +L++E ++ +R C + + ++++ + + A L RL+ RA E ++ +A
Sbjct: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
Query: 345 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 401
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 402 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 435
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 436 SMQARVRELEEQCRSQTE 453
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|153792195 DKFZP434H0735 protein [Homo sapiens]
Length = 1639
Score = 268 bits (686), Expect = 3e-71
Identities = 337/1202 (28%), Positives = 485/1202 (40%), Gaps = 277/1202 (23%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIA-------K 174
N L +AL L +RC L+ EN+ LR++ P + +EKV+RLK K AEL +A +
Sbjct: 377 NWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 175 RLEE---------------------------RARKLQET------------NLRVE---- 191
+L+E RAR L E LR E
Sbjct: 437 KLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLL 496
Query: 192 -----------------GP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 232
GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 497 QARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ---------- 546
Query: 233 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292
Q GA P A G++ E E +++ LE EL ++R++C+
Sbjct: 547 --------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRRECQ 585
Query: 293 SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG 352
L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 586 ELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
Query: 353 VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++ L
Sbjct: 646 ACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQAL 695
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LHP 469
Q + Q+ ES + R + R + S +++Q R L
Sbjct: 696 QCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
Query: 470 GPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPAT 529
P+ L SA S+PQ SE PA+
Sbjct: 752 SPVALGESA----------------SVPQV-----------------------SETVPAS 772
Query: 530 LTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPEG 588
+ +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 773 -----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSA 827
Query: 589 SRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRG 648
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRRG
Sbjct: 828 APAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRG 887
Query: 649 LVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPE 708
LVPSNFVE++ D + LP + DL G S + Q
Sbjct: 888 LVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEAL 926
Query: 709 EEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVN 768
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 927 EEDS----LLSGKAQGVVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQL 970
Query: 769 GELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQ 827
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 971 G-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYLD 1027
Query: 828 LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA 887
R H LT G H P YW T + V
Sbjct: 1028 DREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTM---------SSTVTF 1078
Query: 888 QLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVT 944
GP P + L +R A+ L + LP A G S G+ + +
Sbjct: 1079 DTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY---- 1126
Query: 945 IDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHG 1004
A ++G++V A G ++E SQLQ+ ++V VRTMS G
Sbjct: 1127 ---AVYADGLKVCEVADATAGSTLLE------------FSQLQVPLTWQKVSVRTMSLCG 1171
Query: 1005 ESADSIPAPIT---------PALAPASLPA------RVSCPSPHPSPEARAPLASASP-G 1048
ES DS+PA I P P S RV+ P P A ASP
Sbjct: 1172 ESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHN 1231
Query: 1049 PGDPSSPLQHPAPLGTQEPPGAPPASPSREM-AKGSHEDPPAPCSQEEAGAAVLGTSEER 1107
PG P +EPP SP + ++G A +E A G ++
Sbjct: 1232 PGSCGEPQAKFLEAFFEEPPRR--QSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDL 1289
Query: 1108 TASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSG 1167
S + P + K+ G + + R + P E CQ + +
Sbjct: 1290 LFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQ--EKAAL 1347
Query: 1168 LRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEE-----------EEEEEEEELG 1216
R +K+D + + + SD ++ +EE+E EE E E
Sbjct: 1348 ERVLRQKQDAQGFTPPQLGASQQYA--SDFHNVLKEEQEALCLDLWGTERREERREPEPH 1405
Query: 1217 SR 1218
SR
Sbjct: 1406 SR 1407
Score = 128 bits (322), Expect = 4e-29
Identities = 95/261 (36%), Positives = 127/261 (48%), Gaps = 33/261 (12%)
Query: 1517 RATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARS----------PSETLAYQHLP 1566
R E E G+ KRG ++ PS+A L PA S P + + P
Sbjct: 1395 RREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTGANTP 1453
Query: 1567 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCN 1626
R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G IP
Sbjct: 1454 ARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGR 1513
Query: 1627 MVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEG 1686
+VAE+ V G +Q R + SP GN P V G +G
Sbjct: 1514 LVAEMEV----GTEQT-DRRWRSP-----AQGNLPSVAHLEDFQG---------LTIPQG 1554
Query: 1687 PAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDD 1746
+ G K +P L P M+AA DY+P + + L RAGDV+ V+G MDD
Sbjct: 1555 SSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDD 1611
Query: 1747 DGFYYGELNGQRGLVPSNFLE 1767
GFYYGEL G RGLVP++ L+
Sbjct: 1612 QGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1710 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1767
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVE 895
Score = 57.8 bits (138), Expect = 9e-08
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1480 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1522
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1523 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1574
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1575 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1631
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPD 899
Query: 1632 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1660
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 4e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 596 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 654
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 655 VERVS 659
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 236 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 295
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 296 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 354
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 355 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 414
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 415 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 474
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 475 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 528
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 529 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 584
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 585 APEGSRGGAR 594
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1628 VAEVAV 1633
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 34.7 bits (78), Expect = 0.86
Identities = 59/258 (22%), Positives = 99/258 (38%), Gaps = 35/258 (13%)
Query: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 288
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 289 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 344
++C +L+ E ++ +R C + + ++++ + + A L RL+ RA + ++ +A
Sbjct: 389 RRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSA 448
Query: 345 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 401
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 402 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 435
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 436 SMQARVRELEEQCRSQTE 453
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
sapiens]
Length = 1002
Score = 81.3 bits (199), Expect = 8e-15
Identities = 109/411 (26%), Positives = 178/411 (43%), Gaps = 59/411 (14%)
Query: 100 RPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
+ E E+E L+ + G + NLE L+ E+ + Q + P+ +++
Sbjct: 311 KQEKSELEEKLRVLVTEKAGMQLNLEELQKKLEMTELLL-----QQFSSRCEAPDANQQL 365
Query: 160 RRLKRKNAELAVIAKRLEERARKLQ------ETNLRVEGPQWLH----VRDFDRLLRE-- 207
++ + A+L ++ E R+LQ NL+ E W + + LRE
Sbjct: 366 QQAMEERAQLEAHLGQVMESVRQLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEK 425
Query: 208 --SQREVLRLQRQIA-LRNQRETLPLPPSWPPGPA-----LQARAG---APAPGAPGEAT 256
S V L+ +A LRNQ P PP P GP+ LQA A G G+
Sbjct: 426 ECSMSRVQELETSLAELRNQMAEPP-PPEPPAGPSEVEQQLQAEAEHLRKELEGLAGQLQ 484
Query: 257 PQ-EDADNLPVILGEPEKE----QRVQQLESELSKKRKKCESLEQEARKKQRRC----EE 307
Q +D + L + E E+ +R +L E ++ R++ Q R R E
Sbjct: 485 AQVQDNEGLSRLNREQEERLLELERAAELWGEQAEARRQILETMQNDRTTISRALSQNRE 544
Query: 308 LELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALR----- 362
L+ QL + Q+ +L EN ++ ++ V+ E G+ LG QE+ S L+
Sbjct: 545 LKEQLAELQSGFVKLTNENMEITSALQSEQHVKRE----LGKKLGELQEKLSELKETVEL 600
Query: 363 KSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQRE 422
KSQ QS + +Q L H+++ QQL E E L + + V +LQQ +A+ +
Sbjct: 601 KSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAV 660
Query: 423 HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLD 473
E A Q L+ T + ++A ++ +Q R+ Q SL+A HPG D
Sbjct: 661 AEMARQELQETQERLEAATQQ-NQQLRA---QLSLMA--------HPGEGD 699
Score = 47.8 bits (112), Expect = 1e-04
Identities = 89/387 (22%), Positives = 156/387 (40%), Gaps = 50/387 (12%)
Query: 85 PSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFG-DRPNLELLRALGELRQRCAILKEE 143
PS +Q + R E E + L+A++ + G R N E L EL + + E+
Sbjct: 458 PSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGEQ 517
Query: 144 NQMLRK--SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGP--QWLHV- 198
+ R+ + + R +N EL L+ KL N+ + HV
Sbjct: 518 AEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVK 577
Query: 199 RDFDRLLRESQREVLRLQRQIALRNQR-ETLPLPPSWPPGPALQARAGAPAPGAPGEATP 257
R+ + L E Q ++ L+ + L++Q ++L G Q A A + T
Sbjct: 578 RELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVA------AYQQLTS 631
Query: 258 QEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQN 317
+++ + ++L + Q V QL+ + ++ + E QE ++ Q R E Q +Q +
Sbjct: 632 EKEVLHNQLLL----QTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRA 687
Query: 318 ENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQV 377
+ + L+ G E+E+ E E E + + V Q S + LES E +
Sbjct: 688 QLS-LMAHPGEGDGLDREEEEDEEEEEE---EAVAVPQPMPS-------IPEDLESREAM 736
Query: 378 LKHMREVAQRRQQLEVEHEQARL--SLREKQEEVRRLQQAQAEAQREHEGAV-------- 427
+ E EQARL L+E++ RRL A AQ+E E A
Sbjct: 737 VAFFNSAVA-----SAEEEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGD 791
Query: 428 -------QLLESTLDSMQARVRELEEQ 447
+ L+ ++ +Q+R EL ++
Sbjct: 792 SVCGETHRALQGAMEKLQSRFMELMQE 818
Score = 40.8 bits (94), Expect = 0.012
Identities = 50/231 (21%), Positives = 85/231 (36%), Gaps = 34/231 (14%)
Query: 275 QRVQQLESELSKKRKKCESLEQEARKKQRRCEEL---------------------ELQLR 313
Q + L SE ++ + + AR+K+ E+L Q +
Sbjct: 221 QTIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQQK 280
Query: 314 QAQNENARLVEENS----RLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQS 369
+A N L +E L E ++ E +EL +L + E+ + LQ
Sbjct: 281 KADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLEELQK 340
Query: 370 KLESLEQVLKHMR------EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 423
KLE E +L+ + Q+ QQ E Q L + E VR+LQ + +
Sbjct: 341 KLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENL 400
Query: 424 EGAVQLLESTLDSMQARV---RELEEQCRSQTEQFSLLAQELQAFRLHPGP 471
+G + + M +V RE +E S+ ++ EL+ P P
Sbjct: 401 KGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPP 451
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 80.5 bits (197), Expect = 1e-14
Identities = 105/416 (25%), Positives = 184/416 (44%), Gaps = 66/416 (15%)
Query: 51 QLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFL 110
Q Q LR E+ + K + R E E QQ +R ++E E L
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQER----REQQEERREQQLRREQEERREQQL 351
Query: 111 KAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELA 170
+ + +R +L R E R+ + +E Q LR+ E+++RR ++ E
Sbjct: 352 RREQEE---ERREQQLRREQEEERREQQLRRE--QQLRREQQLRREQQLRREQQLRREQQ 406
Query: 171 VIAKRLEERARKLQ-ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLP 229
+ ++ R ++L+ E LR E + H + ++ RE + + + +R+ L+ + ET
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET-- 464
Query: 230 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 289
E+E+R QQL+ + ++R+
Sbjct: 465 ---------------------------------------ERHEQERRKQQLKRDQEEERR 485
Query: 290 -KCESLEQEARKKQRRCEELELQLRQAQNENARLV--EENSRLSGRATEKEQVEWENAEL 346
+ LE+E R++Q+ E +L+ Q + RL EE RL R ++Q+ E E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 347 RGQLLGVTQER--DSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLRE 404
R QLL +E+ + R+ + + + E +Q+LK RE +R+Q+L+ E E+ RL R
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLK--REEERRQQRLKREQEE-RLEQRL 602
Query: 405 KQEEVRRLQQAQAEAQR------EHEGAVQLLESTLDSMQARVRELEEQCRSQTEQ 454
K+EEV RL+Q + QR E E QLL+S + + R ++L + + + EQ
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSE-EQEERRQQQLRREQQERREQ 657
Score = 77.4 bits (189), Expect = 1e-13
Identities = 88/347 (25%), Positives = 161/347 (46%), Gaps = 35/347 (10%)
Query: 132 ELRQRCAILKEENQML------RKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ- 184
E R+R +L++E + L R+ E EE++R+L+R+ EL + E++ ++L+
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQRLRR 302
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARA 244
E LR + + + +R ++ +RE +R+ LR ++E Q R
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR---------EQQLRR 353
Query: 245 GAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRR 304
QE+ + E E+E+R QQL E +R++ EQ+ R++Q+
Sbjct: 354 ------------EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 305 CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQE--RDSALR 362
E +L+ Q +L E + E+ + + E E R Q L QE RD R
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ-ERREQRLKREQEERRDWLKR 460
Query: 363 KSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQRE 422
+ + + + E +Q LK +E +R + L++E E+ R +++++RR Q+ + E + +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 423 HEGAVQLLESTLDSMQARVRELEEQCRS--QTEQFSLLAQELQAFRL 467
+ + L+ L S Q RE EE+ + E+ L QE + RL
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Score = 72.8 bits (177), Expect = 3e-12
Identities = 90/353 (25%), Positives = 155/353 (43%), Gaps = 38/353 (10%)
Query: 132 ELRQ-RCAILKEENQML----RKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQET 186
+LRQ R +EE Q L R F E E++VRR +R+ L + +ER RK +E
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 187 N--LRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARA 244
L+ Q LH ++ DR E ++++ R +R R Q L P L+
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE----LRSQEPERKFLEEEQ 1522
Query: 245 GAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRR 304
+ +E + +++R QQ + +K ++ E L QE ++Q
Sbjct: 1523 QLHRQQRQRKFLQEEQ---------QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 305 CEE------LELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELR--GQLLGV--- 353
+E LE Q + Q + + +E+ +L + +++ + + + R QLL
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 354 ----TQERDSALRKSQGLQSKLESLEQVLKHMREVAQR-RQQLEVEHEQARLSLREKQEE 408
QERD + + Q + + EQ L+H R+ R +QL E E+ +L +E+ +
Sbjct: 1634 QQLHRQERDRKFLEEEP-QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 409 VRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQE 461
R +Q +RE + + + ++ + RE EEQ R +TEQ L QE
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFRE-EEQLRQETEQEQLRRQE 1744
Score = 67.0 bits (162), Expect = 2e-10
Identities = 93/376 (24%), Positives = 160/376 (42%), Gaps = 33/376 (8%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLR 148
QQ S +R ++E E LK + + L+ E R+ + +EE + +
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Query: 149 KSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRES 208
+ + E +RLKR+ E RLE+ R+ E L+ E P+ + + L +S
Sbjct: 589 RLKREQEERLEQRLKREEVE------RLEQEERR--EQRLKREEPE----EERRQQLLKS 636
Query: 209 QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVIL 268
+ + R Q+Q+ Q L+ R + + + L
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQR-----------LKREHEEERREQEL 685
Query: 269 GEPEKEQRVQQLESELSKKRKKCESLEQEAR--KKQRRCEELELQLRQAQNENARLVEEN 326
E E+EQ ++++S + K + + ES E +AR K R + E Q R+ + E R E
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE- 743
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMR-EVA 385
S L + E+ + + E R Q + + R Q L ++ EQ + +R E
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 386 QRRQQL----EVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARV 441
Q+R+Q E E EQ R RE+++E++ L++ + +RE +Q E L Q R
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER- 862
Query: 442 RELEEQCRSQTEQFSL 457
R +EQ R Q ++ L
Sbjct: 863 RRSQEQRRDQKWRWQL 878
Score = 63.2 bits (152), Expect = 2e-09
Identities = 89/351 (25%), Positives = 152/351 (43%), Gaps = 31/351 (8%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRL---EERARKLQETNL 188
+ R+ + +EE Q+L + +++ R RK EL ++L E R+ QE
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 189 RVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSW-PPGPALQARAGAP 247
+ + L + ++LLRE + + R + + R + E P + R
Sbjct: 1109 QCREEEELQQEE-EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 248 APGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEE 307
E QE+ L E+E+R Q+ E + ++ E L+++ RK++ R E+
Sbjct: 1168 RQYREEEELQQEEEQLL-----REEQEKRRQERERQYREE----EELQRQKRKQRYRDED 1218
Query: 308 LELQLR-QAQNENARLVEENSRLSGRATEKEQV-EWENAELRGQ--------LLGVTQER 357
L+ Q + E V +N ++ + E EQ + E+++LR + LLG QER
Sbjct: 1219 QRSDLKWQWEPEKENAVRDN-KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 358 D--SALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
D R+ Q EQ+ + ++ A+RR + E +Q LRE++EE RR Q+
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL---LREEREEKRRRQET 1334
Query: 416 QAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
+ RE E +Q E Q R R+ E+ EQ +E Q R
Sbjct: 1335 DRKF-REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Score = 62.4 bits (150), Expect = 4e-09
Identities = 95/407 (23%), Positives = 165/407 (40%), Gaps = 63/407 (15%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEK 158
+ PE+E + LK++ +R +L R E R++ +EE + L + E EE+
Sbjct: 623 EEPEEERRQQLLKSEEQE---ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Query: 159 VRRLKRKNAELAVIAKRLEERARKLQ-----ETNLRV----------EGPQWLHVRDFDR 203
R + E +R++ R K Q E + R EG + ++ R
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739
Query: 204 LLRESQ---REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQED 260
RES+ +E R RQ QR +W +A + +
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDF----TWQ-----------------WQAEEKSE 778
Query: 261 ADNLPVILGEPEKEQRVQQLESELSKKRKKC---ESLEQEARKKQRRCEELELQLRQAQN 317
+ P +EQR +QL +E ++R++ E E+E R++QRR E ELQ + +
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 318 ENARLV-------EENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSK 370
+ R EE+ + + Q + + + R QL + R L LQ +
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 371 LESLEQVLKHMREVAQ-------RRQQLEVEH-EQARLSLREKQ---EEVRRLQQAQAEA 419
L +Q+L+ E Q RRQ+ E ++ E+ +L E+Q EE + ++ + E
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 420 QREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
Q + +Q E L + R +E+ + E+ L +E Q R
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Score = 62.4 bits (150), Expect = 4e-09
Identities = 97/392 (24%), Positives = 166/392 (42%), Gaps = 49/392 (12%)
Query: 85 PSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEEN 144
P+L +Q Q E+EE++ + K +R E + E Q +L+EE
Sbjct: 893 PALQEQLRKEQQLLQE-EEEELQREEREKRRRQEQERQYREEEQLQQEEEQ---LLREER 948
Query: 145 QMLRKSSFPETEEKVRRLKRKNAELA---VIAKRLEERARKL-QETNLRVEGPQWLHVRD 200
+ R+ K ++L++K +L +R +ER +K +E L+ E Q L
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 201 FDRLLRESQREV-----LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEA 255
R +E +R+ L+ + + LR +RE L Q R E
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-----ERQYRE---------EE 1054
Query: 256 TPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKK--QRRCEELELQLR 313
Q++ + L LGE + +R Q+LE + K+ + + EQ R++ +RR +E E Q R
Sbjct: 1055 ELQQEEEQL---LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Query: 314 QA----QNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQS 369
+ Q E L EE + + E++ E E V QE + LR+ +
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEE---------VQQEEEQLLREEPEKRR 1162
Query: 370 KLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQ--EEVRRLQQAQAEAQREHEGAV 427
+ E LE+ + E+ Q +QL E ++ R RE+Q EE +Q + + R+ +
Sbjct: 1163 RQE-LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 428 QLLESTLDSMQARVRELEEQCRS-QTEQFSLL 458
L + VR+ + C+ + EQF L
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Score = 61.6 bits (148), Expect = 7e-09
Identities = 63/215 (29%), Positives = 111/215 (51%), Gaps = 27/215 (12%)
Query: 270 EPEKEQRVQ-QLESELSKKRKKC---ESLEQEARKKQRRCEELELQLRQAQNENARLVEE 325
E ++Q+ + QLE E ++R +L+++ RK+Q+ +E E +L++ + E R E+
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ 926
Query: 326 NSRLSGRAT---EKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL--EQVLKH 380
+ E+EQ+ E E R + QER+ RK + LQ K E L E+ K
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRR-----QERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 381 MREVAQR--RQQLEVEHEQARLSLREKQEEVRRLQ-----QAQAEAQREHEGAVQLLEST 433
R+ ++ R++ E++ E+ +L LRE++E+ RR + + + E Q+E E QLL
Sbjct: 982 RRQEREKKYREEEELQQEEEQL-LREEREKRRRQEWERQYRKKDELQQEEE---QLLREE 1037
Query: 434 LDS--MQARVRELEEQCRSQTEQFSLLAQELQAFR 466
+ +Q R R+ E+ Q E+ LL +E + R
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Score = 60.1 bits (144), Expect = 2e-08
Identities = 99/401 (24%), Positives = 160/401 (39%), Gaps = 70/401 (17%)
Query: 102 EDEEVEAFLKAKLN--MSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
E+E E +LK + +R +L R E R++ +EE + L++ +E+++
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL--RSEQQL 538
Query: 160 RRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQ- 218
RR + + E + KR EE+ + + R++ Q R L RE +R RL+R+
Sbjct: 539 RREQEERREQ--LLKREEEKRLEQERREQRLKREQ--EERRDQLLKREEERRQQRLKREQ 594
Query: 219 ---IALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQ 275
+ R +RE + E QE+ + EPE+E+
Sbjct: 595 EERLEQRLKREEV-------------------------ERLEQEERREQRLKREEPEEER 629
Query: 276 RVQQLESELSKKRKKCE-SLEQEARKKQR-----RCEELELQLRQAQNENAR---LVEEN 326
R Q L+SE ++R++ + EQ+ R++QR E LE +L++ E R L EE
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 327 SRLSGRATEKEQVEWE-----NAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHM 381
+ + +W+ A+ R + + R+ Q + K E L+
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 382 REVAQRRQQLEVEHE----------------QARLSLREKQEEVRRLQ-QAQAEAQREHE 424
E RQQ E E + RLS R E R Q +A+ QRE
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 425 GAVQLLESTLDSMQARVRELEEQCRSQTEQFSL--LAQELQ 463
+ E Q R RE E Q + EQ AQ+LQ
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Score = 59.7 bits (143), Expect = 2e-08
Identities = 99/424 (23%), Positives = 170/424 (40%), Gaps = 86/424 (20%)
Query: 102 EDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRR 161
E+EE++ + L R EL R + R+ + +EE Q+LR+ +++ R
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELER---QYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 162 LKRKNAELAVIAKRL--EERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI 219
R+ EL ++L EE+ ++ QE +R RE + E+ R +R+
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQER---------------ERQYREEE-ELQRQKRKQ 1212
Query: 220 ALRNQRETLPLPPSWPPGPALQARAGAP-APGAPGEATPQ---------EDADNLPVILG 269
R++ + L W P R G E Q + +L +LG
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 270 EPEKEQRVQ----------------QLESELSKKRKKCESLEQEA-------RKKQRRCE 306
E ++ R Q QLE E K+ K+ + QE R+++RR +
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 307 ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT----------QE 356
E + + R E +L++E R E+++ ++ ELR Q G QE
Sbjct: 1333 ETDRKFR----EEEQLLQEREEQPLRRQERDR-KFREEELRHQEQGRKFLEEEQRLRRQE 1387
Query: 357 RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR----- 411
R+ K + Q + + EQ L+ R+ R ++ ++ ++ RE++++VRR
Sbjct: 1388 RERKFLKEEQ-QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Query: 412 --------LQQAQAEAQREHEGAVQLLESTLDSMQARVR---ELEEQCRSQTEQFSLLAQ 460
L+Q + RE E +Q E Q R R E E+Q R Q Q
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 461 ELQA 464
EL++
Sbjct: 1507 ELRS 1510
Score = 59.7 bits (143), Expect = 2e-08
Identities = 97/401 (24%), Positives = 165/401 (41%), Gaps = 53/401 (13%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EE 157
Q E F + +L +R LE + L +++ L+EE Q+ R+ + ++
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 158 KVRRLK-----RKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREV 212
+ R+ + R+ E ++++ +R +L+E +R + + + D +L R+ ++
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 272
LR +R R + L Q R + E+ L
Sbjct: 1613 LRQERDRKFREDEQLL------------QEREEQQLHRQERDRKFLEEEPQL-------R 1653
Query: 273 KEQRVQQLESELSKKRKKCESLEQEARKKQ-------RRCEELELQLRQAQNENARLVEE 325
+++R QQL + +K ++ E L QE ++Q R+ E E QLR+ + E L EE
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 326 NS----RLSGRATEKEQV--EWENAELRGQ-----LLGVTQ---ERDSALRKSQGLQSKL 371
L + E+EQ+ E E +LR Q +L Q ER+ + Q K
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 431
EQ L+ RE Q R Q + LR+++EE + Q + R E +QL E
Sbjct: 1774 REEEQ-LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 432 STLDSMQARVRE--LEEQC----RSQTEQFSLLAQELQAFR 466
Q R R+ EEQ +S+ E+ L +E Q R
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873
Score = 58.9 bits (141), Expect = 4e-08
Identities = 92/354 (25%), Positives = 150/354 (42%), Gaps = 47/354 (13%)
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA---ELAVIAKRLE 177
R L L E R+R + EE Q + PE EEK +R +++ EL + + +
Sbjct: 781 RQRLSARPPLREQRER-QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 178 ----ERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPS 233
ERA++LQE +G Q D +R + QR + + Q+ +R L
Sbjct: 840 LQRRERAQQLQEEE---DGLQ----EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 234 WPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCES 293
PALQ + + QE+ + L E + Q ++ E + +++ E
Sbjct: 893 ----PALQEQLRKE------QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Query: 294 LEQEARKKQRRCEELELQLRQ----AQNENARLVEENSRLSGRATEKEQVEWENAELRGQ 349
L +E R+K+RR +E E Q R+ Q E L EE + + EK+ E E + +
Sbjct: 943 LLREEREKRRR-QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 350 LL-------GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE--QARL 400
L QE + RK LQ + E L + + R + +R +Q E E Q
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 401 SLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQ 454
L ++ E RR Q+ + + ++E E +Q E L +RE E+ R Q +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEE--LQQEEEQL------LREEPEKRRRQERE 1107
Score = 58.2 bits (139), Expect = 7e-08
Identities = 80/343 (23%), Positives = 146/343 (42%), Gaps = 45/343 (13%)
Query: 140 LKEENQMLRKSSF--PETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLH 197
L+EE + R + + P +E++R+ ++ E +R E R+ QE + + L
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 198 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSW-PPGPALQARAGAPAPGAPGEAT 256
+ ++LLRE + + R +R+ R ++ P + R E
Sbjct: 938 QEE-EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 257 PQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEAR--KKQRRCEELELQLRQ 314
QE+ +L E +++R Q+ E + KK + + EQ R +++RR +E E Q R+
Sbjct: 997 QQEEEQ----LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE 1052
Query: 315 A---QNENARLVEENSRLSGRAT-------------EKEQVEWENAELRGQLLGVTQERD 358
Q E +L+ E R E+EQ+ E E R + QER+
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR-----QERE 1107
Query: 359 SALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEH--------EQARLSLREKQEEVR 410
R+ + LQ + E L +RE ++R++ E+E +Q L ++ E R
Sbjct: 1108 RQCREEEELQQEEEQL------LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 411 RLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
R Q+ + + + E E + + + + R +E E Q R + E
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Score = 55.8 bits (133), Expect = 4e-07
Identities = 94/389 (24%), Positives = 162/389 (41%), Gaps = 45/389 (11%)
Query: 80 AEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAI 139
A+AC +LGQ DEE A K ++ R + R RQ
Sbjct: 82 AQACYYALGQATGL---------DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQ---- 128
Query: 140 LKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVR 199
L+EE R+ E E ++ + ++ + +RLE+R R+ ++ L + +W
Sbjct: 129 LEEEPGQRRRQKRQEQERELAEGEEQSEK----QERLEQRDRQRRDEELWRQRQEWQ--- 181
Query: 200 DFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE 259
+R R ++ E Q Q ++ E P L+ R G Q+
Sbjct: 182 --EREERRAEEE----QLQSCKGHETEEFPDEEQLRRRELLELRR-------KGREEKQQ 228
Query: 260 DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNEN 319
+ + E+E+ ++ E+ L RK+ E L++E ++QR +E E QLR+ + +
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVL---RKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 320 ARLV-EENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
R +E + R ++Q+ + E R + + R+ R+ Q + + + L +
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQ--EERREQQERREQQEERREQQLRREQ 343
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEV-RRLQQAQAEAQREHEGAVQLLESTLDSM 437
+ RE RR+Q E EQ LR +QEE RR QQ + E Q E ++ +
Sbjct: 344 EERREQQLRREQEEERREQ---QLRREQEE-ERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 438 QARVRELEEQCRSQTEQFSLLAQELQAFR 466
Q R RE + + Q + L +E Q R
Sbjct: 400 QLR-REQQLRREQQLRREQQLRREQQLRR 427
Score = 52.0 bits (123), Expect = 5e-06
Identities = 92/412 (22%), Positives = 168/412 (40%), Gaps = 68/412 (16%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET--- 155
Q E+EEV+ + L R EL R + R+ + +EE Q+LR+
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELER---QYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 156 ------EEKVRRLKRKNA-----------------------ELAVIAK-RLEERARKLQE 185
EE+++R KRK + V K R E+ R+L++
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 186 TNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAG 245
+ LR Q +D LL E Q +R+ + R +P L+
Sbjct: 1256 SQLRDRQSQ----QDLQHLLGEQQERDREQERRRWQQRDRH-------FPEEEQLEREEQ 1304
Query: 246 APAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRC 305
A + ++ + ++ E E+++R Q+ + + ++ + + E++ ++Q R
Sbjct: 1305 KEA-----KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 306 EELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG--VTQERDSALRK 363
+ + + Q + + +EE RL + E++ ++ E +LR Q + Q+RD R+
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK-EEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 364 SQGLQSKLE-------SLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQ 416
+ S+ E +QV + RE R+ LE E + + R+ +EE + LQ+ +
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERE----RKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 417 AEAQREHEGAVQLLESTLD-SMQARVRELEEQ-CRSQTEQFSLLAQELQAFR 466
+ E + LE Q R R+ EQ RSQ + L +E Q R
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Score = 46.6 bits (109), Expect = 2e-04
Identities = 86/350 (24%), Positives = 140/350 (40%), Gaps = 74/350 (21%)
Query: 141 KEENQMLRKS---SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLH 197
+EE Q+ R+ F E E ++RR +R+ ++ E + LQE Q L
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE-----EQQLR 1685
Query: 198 VRDFDRLLRESQREVLRLQRQIALRNQRETL---PLPPSWPPGPALQARAGAPAPGAPGE 254
++ DR RE ++++ R +R+ + + L L + L+ +
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR------------Q 1733
Query: 255 ATPQEDA---DNLPVILGE----PEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEE 307
T QE + IL E PE+E++ Q E +K ++ E L QE ++Q R +E
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQ-QLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Query: 308 LELQLRQAQNENARLVEENSRLSGR----ATEKEQVEWENAELRGQLLGVTQERDSALRK 363
+ + R+ + E+ R R E+EQ++ E E R + QERD R
Sbjct: 1793 SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR-----LRQERDRQYRA 1847
Query: 364 SQ--GLQSKLESLEQVL-------------KHMREVAQRRQQLEVEHEQARLSLREKQEE 408
+ Q K EQ L + +RE RRQQ +EE
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ---------------KEE 1892
Query: 409 VRRLQQAQAEAQREHEGAVQLLE---STLDSMQARVRELEEQCRSQTEQF 455
R Q + ++Q E +G +LLE S+ R L E + Q Q+
Sbjct: 1893 QRHRQVGEIKSQ-EGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQY 1941
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.4 bits (176), Expect = 4e-12
Identities = 88/377 (23%), Positives = 162/377 (42%), Gaps = 50/377 (13%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRAL---GELRQRCAILKEENQ 145
+QA S+ ++ D +E K + D +LEL R EL+++ A L+E+ Q
Sbjct: 166 EQALSAVATQKKKADRYIEELTKER------DALSLELYRNTITDEELKEKNAKLQEKLQ 219
Query: 146 MLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLL 205
++ +S E + V+ LKRK LE L + L+ E D L
Sbjct: 220 LV-ESEKSEIQLNVKELKRK----------LERAKLLLPQQQLQAEA---------DHLG 259
Query: 206 RESQREVLRLQRQIA---LRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDAD 262
+E Q +LQ Q+ L N+ W +Q R E QE +
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER----------EEKIQEQEE 309
Query: 263 NLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEE-LELQLRQAQNENAR 321
I + EK +R +++ E +K ++ E + E +K R EE + Q + + E R
Sbjct: 310 K---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 366
Query: 322 LVEENSRLSGRATEKEQVEWENAE-LRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKH 380
EE R + E+E W E +R Q + ++ + + + + + E + + +
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 381 MREVAQRRQQLEVEHEQARLSLREKQEEVRR---LQQAQAEAQREHEGAVQLLESTLDSM 437
M+E ++ ++ E + + +RE++E++R + Q Q E E EG + E+ +
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486
Query: 438 QARVRELEEQCRSQTEQ 454
+ ++R EE+ R Q ++
Sbjct: 487 EEKMRRQEEKIREQEKK 503
Score = 63.2 bits (152), Expect = 2e-09
Identities = 68/316 (21%), Positives = 132/316 (41%), Gaps = 26/316 (8%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVE 191
EL R +EE ++ E EEK++ + K E +R EE + +E R E
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 192 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 251
W + R L E E +++ Q R + E + + R A
Sbjct: 337 EMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR---------EQEKRQEQEAKMW 386
Query: 252 PGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQ 311
E +E + + E+E+ +Q+ E ++ ++ +K E+E ++++ + E +
Sbjct: 387 RQEEKIREQEEKIR------EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
+R+ Q + R EE R E+E++ E E G+ G E+++ K Q + K+
Sbjct: 441 IRE-QEKKIREQEEKIR------EQEEMMQEQEEKMGEQEGKMCEQEA---KMQEQEEKM 490
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 431
E+ ++ + + +++ E E+ EK E Q E +E E ++ E
Sbjct: 491 RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
Query: 432 STLDSMQARVRELEEQ 447
+ + R+R+ EE+
Sbjct: 551 EKMREQEVRLRQQEEK 566
Score = 51.6 bits (122), Expect = 7e-06
Identities = 51/281 (18%), Positives = 125/281 (44%), Gaps = 51/281 (18%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIA----KRLEERARKLQETNLRVEGPQWL 196
KEE ++ E EEK+R L+ K E I KR EE + QE E W
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 387
Query: 197 H---VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPG 253
+R+ + +RE Q E+++ Q + + Q E + W +Q
Sbjct: 388 QEEKIREQEEKIRE-QEEMMQEQEE-KMGEQEEKM-----WEQEEEMQ------------ 428
Query: 254 EATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLR 313
E+E+++++ E ++ ++ KK E++ R+++ +E E ++
Sbjct: 429 ------------------EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 314 QAQN----ENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQS 369
+ + + A++ E+ ++ ++E++ + ++R Q + ++ + + + +
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMR---RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 527
Query: 370 KLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVR 410
+ E + + + M+E ++ ++ E + + + LR+++E+++
Sbjct: 528 QEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 32.0 bits (71), Expect = 5.6
Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 10/92 (10%)
Query: 1203 EEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCE-----TDSDEEILEQIL 1257
E+EE +E+EE++G + +Q A +E + Q + E + +E+I EQ
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-- 514
Query: 1258 ELPLQQFCSKKLFSIPEE--EEEEEEDEEEEK 1287
+ Q +K++ E+ E+EE+ E+EEK
Sbjct: 515 -EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 545
Score = 31.2 bits (69), Expect = 9.5
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 1202 EEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPL 1261
+E EE+ +E+EE++ + ++Q +E + Q + E + E+I EL
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE------EKIRELEE 351
Query: 1262 QQFCSKKLFSIPEEEEEEEEDEEEEK 1287
+ +K+ E+ +EEE+ E+EK
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEK 377
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 72.0 bits (175), Expect = 5e-12
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 41/325 (12%)
Query: 125 ELLRALGELRQRCAILKEE--NQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARK 182
ELL++ QRC EE Q+ R+ +E+ R +R+ AEL + ++LEE +
Sbjct: 733 ELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSA 792
Query: 183 LQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQA 242
L LR E + ++ R Q E+ L++Q+ L Q +W G +
Sbjct: 793 LTRA-LRAEFEKGREEQE-----RRHQMELNTLKQQLELERQ--------AWEAGRTRKE 838
Query: 243 RAGAPAPGAPGEATPQEDAD-NLPVILGEPE------KEQRVQQLESELSKKRKKCES-- 293
A ++ D + +++ E KE+ + ES + + R K E+
Sbjct: 839 EAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL 898
Query: 294 --LEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 351
LEQ RK Q RC EL+ QL +A+ EN RL G +KE+ + + QL
Sbjct: 899 SELEQSERKLQERCSELKGQLGEAEGENL-------RLQGLVRQKERALEDAQAVNEQLS 951
Query: 352 GVTQERDSALRKSQGLQSKLESLEQVLKHMR-EVA--QRRQQLEVE--HEQARLSLREKQ 406
+R Q + +L + E+ + + E+A Q RQQLE+E H + + +L K+
Sbjct: 952 SERSNLAQVIR--QEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1009
Query: 407 EEVRRLQQAQAEAQREHEGAVQLLE 431
E V L+ A + + +LLE
Sbjct: 1010 EAVSSLRTQHEAAVKRADHLEELLE 1034
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/220 (27%), Positives = 102/220 (46%), Gaps = 36/220 (16%)
Query: 270 EPEKEQRVQQLESELSKKRK--KCESLEQEARKKQRRCEELELQLRQAQNENARLVEENS 327
EPE ++ + + + E+ + + + E L+ + R QR + E Q + E L ++
Sbjct: 709 EPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQER 768
Query: 328 RLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQR 387
RA ++++ E E ELR QL +E SAL ++ + + EQ +H E+
Sbjct: 769 E---RARQRQRAELE--ELRQQL----EESSSALTRALRAEFEKGREEQERRHQMELNTL 819
Query: 388 RQQLEVEH----------EQARLSLREKQ--EEVR------------RLQQAQAEAQREH 423
+QQLE+E E+A L RE++ EE+R RL+ A A+ E
Sbjct: 820 KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 879
Query: 424 EGAVQ-LLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
E A + ++ D +A + ELE+ R E+ S L +L
Sbjct: 880 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQL 919
Score = 44.3 bits (103), Expect = 0.001
Identities = 48/188 (25%), Positives = 91/188 (48%), Gaps = 19/188 (10%)
Query: 277 VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 336
+ QL + +KCE++ E +++ +RC E ++ QAQ ++ +++ L ATEK
Sbjct: 631 IDQLIEDKKVLSEKCEAVVAELKQEDQRCTE---RVAQAQAQHELEIKKLKELMS-ATEK 686
Query: 337 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE 396
+ E +E ++ VT +GL+ +++ L + +H +EV RR + E E
Sbjct: 687 ARREKWISEKTKKIKEVT---------VRGLEPEIQKL--IARHKQEV--RRLKSLHEAE 733
Query: 397 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFS 456
+ R Q +R+ ++ + + +RE E Q + + Q + ELEE + E S
Sbjct: 734 LLQSDERASQRCLRQAEELREQLEREKEALGQ--QERERARQRQRAELEELRQQLEESSS 791
Query: 457 LLAQELQA 464
L + L+A
Sbjct: 792 ALTRALRA 799
Score = 33.1 bits (74), Expect = 2.5
Identities = 24/100 (24%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 353 VTQERDSALRK--------SQGLQSKLESLEQVL-KHMREVAQRRQQLEVEHEQARLSLR 403
+ Q+RD R+ S+ LQ + E E + +H+ + Q + +V E+ +
Sbjct: 591 LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVA 650
Query: 404 EKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
E ++E +R + A+AQ +HE ++ L+ + + + RE
Sbjct: 651 ELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE 690
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 71.6 bits (174), Expect = 6e-12
Identities = 118/475 (24%), Positives = 205/475 (43%), Gaps = 62/475 (13%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRA---LGEL---RQRCAIL 140
L QQ + A ++ EE+E +A + ELLRA LGEL RQ+ A
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGL------RAELLRAQRELGELIPLRQKVAEQ 1419
Query: 141 KEENQMLR--KSSFPETEEKVRRLKRKNAELAVIAKRLEERARK-LQETNLRVEGPQWLH 197
+ Q LR K+S+ E ++ LK+ + LA + L ERA Q + ++ + +
Sbjct: 1420 ERTAQQLRAEKASYAE---QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY 1476
Query: 198 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP 257
V++ + +++ + +QR+ A RE + + GA
Sbjct: 1477 VQELAAVRADAETRLAEVQRE-AQSTARELEVMTAKYE---------GAKVKVLEERQRF 1526
Query: 258 QEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQN 317
QE+ L + + E QR Q + E + KK +Q ++ +Q++ + ++ Q ++Q
Sbjct: 1527 QEERQKLTAQVEQLEVFQREQTKQVE--ELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
Query: 318 ENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQV 377
E RL + + L + ++KEQ E+ +L Q+ D+ +++Q LQ +L SLEQ+
Sbjct: 1585 EAQRLQAQLNELQAQLSQKEQAA-EHYKL--QMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641
Query: 378 LKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSM 437
K +E+ ++L E +QA L +E ++ R L + + S+
Sbjct: 1642 QKENKELRAEAERLGHELQQAGLKTKEAEQTCRH------------------LTAQVRSL 1683
Query: 438 QARVRELEEQCRSQTEQFSLLAQELQAFRLHPGP-LDLLTSALDCGSLGDCPPPPCCCSI 496
+A+V ++Q R +F + L++ P LDL +LD S + P +
Sbjct: 1684 EAQVAHADQQLR-DLGKFQVATDALKSREPQAKPQLDLSIDSLDL-SCEEGTPLSITSKL 1741
Query: 497 P--QPCRGSGPKDLDLPPGSP--GRCTPKSSEPAPATLTGVPRRTAKKAESLSNS 547
P QP S P + P SP R PK T +P R+ ES +S
Sbjct: 1742 PRTQPDGTSVPGE----PASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDS 1792
Score = 62.0 bits (149), Expect = 5e-09
Identities = 85/373 (22%), Positives = 159/373 (42%), Gaps = 32/373 (8%)
Query: 105 EVEAFLKAKLNMSFGDRPNLE-----LLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
E +A L+ +L+ + D+ LE L L +L + + L ++N K ++
Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL-QDNPPQEKGEVLGDVLQL 415
Query: 160 RRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI 219
LK++ A LA +L+ R L+ + E F+ ++ + LQ I
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475
Query: 220 ALRNQRETLPLPPSWPPGPALQAR-AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQ 278
+ +Q + S G L A+ A + AT Q+ L + + +++Q
Sbjct: 476 SNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA-- 533
Query: 279 QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQ-AQNENARLVEENSRLSGRATEKE 337
QL L ++ + + L + + ++ E QL++ A+ + A + +L+ A E+E
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 338 QVEWENAELRGQLLGVTQERDSALRKSQGLQ----SKLESLEQVLKHMREVAQRRQQLEV 393
A LR ERD+AL++ + L+ +KLE L+Q L+ E Q
Sbjct: 594 ------ASLR--------ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
Query: 394 EHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
+ ++ + L K EE++ + + Q E + V LE L S Q + E E + + +
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
Query: 454 QFSLLAQELQAFR 466
L ++LQA +
Sbjct: 700 ----LQEQLQALK 708
Score = 58.5 bits (140), Expect = 6e-08
Identities = 85/357 (23%), Positives = 157/357 (43%), Gaps = 58/357 (16%)
Query: 134 RQRCAILKEENQMLRKSSFPETEEKVR--------RLKRKNAELAVIAKRLEERARKLQE 185
+++ LKEE + R+ E +EKV ++ R+ ELA + L +++QE
Sbjct: 832 QEQLMTLKEECEKARQE-LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 186 TNLRVEGPQWLHVRDFDRLLRE----SQREVLRLQRQIALRN-QRETLPLPPSWPPGPAL 240
+R + + D L+E + +EV RL+ + Q+ET P
Sbjct: 891 KEVRAQ-----KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP---- 941
Query: 241 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 300
ARAG P E ++ + E+ +Q+ +EL +R + +E + ++
Sbjct: 942 -ARAGDRQPEWLEEQQGRQFCSTQAALQA---MEREAEQMGNEL--ERLRAALMESQGQQ 995
Query: 301 KQRRCEELELQLRQAQNENARLVEENSR------LSGRATEKEQVEWENA--ELRGQLLG 352
++ R Q + E ARL +E R L A + ++ +NA E R +
Sbjct: 996 QEER--------GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 353 VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
+ + AL + +G +L L + E AQ + E E+ R ++++ +E++ +
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGL-----EAAQIK-----ELEELRQTVKQLKEQLAKK 1097
Query: 413 QQAQAE---AQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
++ A AQ E G + L++++A V +LE+QC+ Q EQ L + L+A R
Sbjct: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
Score = 55.8 bits (133), Expect = 4e-07
Identities = 55/215 (25%), Positives = 98/215 (45%), Gaps = 21/215 (9%)
Query: 254 EATPQEDADNLPVILGEPEKEQR-----VQQLESELSKKRKKCESLEQEARKKQRRCEEL 308
EAT Q+ A L E E R ++QLE+ +K K E L+Q+ + +
Sbjct: 575 EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634
Query: 309 ELQLRQAQNENARLVEENSRLSG----RATEKEQVEWENAELRGQLLGVTQ---ERDSAL 361
+ + QAQ E A L + L E+ + + + AEL QL Q E++
Sbjct: 635 QTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA 694
Query: 362 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
++ LQ +L++L++ LK + LE E +A +L E+Q + L+
Sbjct: 695 QEKDQLQEQLQALKESLK------VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Query: 422 EHEGAVQLLE---STLDSMQARVRELEEQCRSQTE 453
+H+ + LE + ++AR+++L E +++TE
Sbjct: 749 QHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Score = 53.1 bits (126), Expect = 2e-06
Identities = 65/243 (26%), Positives = 103/243 (42%), Gaps = 46/243 (18%)
Query: 255 ATPQEDADNLPVILGEPEKEQRVQQLE-SELSKKRKKCESLEQEARKKQRRCEELELQLR 313
A Q+ D L ++ ++Q LE EL + R K ESL + ++C++L+ +
Sbjct: 252 AMMQQRIDRLALL----NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 314 QAQNENARLVEENSRLSGRATE--------------------KEQVEW--ENAELRGQLL 351
Q + +L EEN LS + E K EW + A+L +L
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367
Query: 352 GVTQERDSALRKSQGLQSKLESLEQVLKHMR--------EVAQRRQQLE-VEHEQARLSL 402
Q++ K++ LQ KL LE+ L ++ EV QLE ++ E A L+
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427
Query: 403 REKQ--------EEVRRLQQAQAEAQREH-EGAVQLLESTLDSMQARVRELEEQCRSQTE 453
Q E R Q+A+ A+R H E Q L S + +Q+ + L Q + + E
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL-SQAKEELE 486
Query: 454 QFS 456
Q S
Sbjct: 487 QAS 489
Score = 53.1 bits (126), Expect = 2e-06
Identities = 48/200 (24%), Positives = 92/200 (46%), Gaps = 34/200 (17%)
Query: 276 RVQQLESELSKKRKKCESLEQEARKKQRRCE----ELELQLRQAQNENARLVEENSRLSG 331
+ Q+ ++ELS+K ++ ++ + AR++Q + ELELQLR Q
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ-------------- 685
Query: 332 RATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSK-----LESLEQVLKHMREVAQ 386
+ATEKE+V E +L+ QL Q +L+ ++G + ++LE+ + + E+
Sbjct: 686 KATEKERVAQEKDQLQEQL----QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
Query: 387 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEE 446
+ L +H++ R L E++ + L+ + H+ ++L L A E
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 801
Query: 447 QCRSQTEQFSLLAQELQAFR 466
+C L +E+ A+R
Sbjct: 802 ECEQ-------LVKEVAAWR 814
Score = 50.8 bits (120), Expect = 1e-05
Identities = 102/474 (21%), Positives = 188/474 (39%), Gaps = 68/474 (14%)
Query: 53 QELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLK 111
QE S E K P G +P + +G + C QA E E + A L
Sbjct: 930 QETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALM 989
Query: 112 AKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRR-LKRKNAELA 170
+R E R + L Q + + L K++ E E +++ L + E A
Sbjct: 990 ESQGQQQEERGQQE--REVARLTQERG-RAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 171 VI----AKRLEERARKLQE-TNLR-VEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ 224
+ A L E+ K QE LR +E Q + + + +++ + ++ + +++ A +
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVIL-----GEPEKEQRVQQ 279
++ + P GP L+A + QE AD+L L E++ ++
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET 1166
Query: 280 LESELSKKRKKCESLEQEARKKQRRC--------------EELELQLRQAQNENAR---- 321
L+ +L +K ++ + QR +E + Q+ + + E R
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
Query: 322 ---LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLES----- 373
L EE S L+ + EKE E+ EL+ ++ +++ + + LQ++ S
Sbjct: 1227 ISSLEEEVSILNRQVLEKEG---ESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA 1283
Query: 374 ------LEQVLKHMREVAQR--------RQQLEVEHEQAR---LSLREKQEEVRRLQQAQ 416
L + ++ +RE A++ RQ+L + E+A L+ QE+ + +QA
Sbjct: 1284 AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343
Query: 417 AEAQREHEGAVQLLESTL------DSMQARVRELEEQCRSQTEQFSLLAQELQA 464
+ Q EH L+ L +QA E++ R + EQ A L+A
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397
Score = 50.4 bits (119), Expect = 2e-05
Identities = 113/482 (23%), Positives = 183/482 (37%), Gaps = 97/482 (20%)
Query: 53 QELRSEESSKPKGDGS-SRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDE--EVEAF 109
++L +E G G+ S G T+P G + L +L + S CQ+ +++ +E
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPK--LEALRAEVSKLEQQCQKQQEQADSLERS 1149
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAE- 168
L+A+ LE L+ G+L ++ L L + + + AE
Sbjct: 1150 LEAERASRAERDSALETLQ--GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
Query: 169 --LAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRE 226
A +A+ +E RK + E V +R + E + E L+R + +++
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEE-----EVSILNRQVLEKEGESKELKRLVMAESEKS 1262
Query: 227 TLPLPPSWPPGPALQARAGA-PAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELS 285
L+ R A A A E + L + VQ L E
Sbjct: 1263 Q-----------KLEERLRLLQAETASNSARAAERSSAL---------REEVQSLREEAE 1302
Query: 286 KKRKKCESLEQEARKKQRRCEELELQLRQ-----AQNENARLVEENSRLSGRATEKE--- 337
K+R E+L QE + R EEL +L+ Q E A + S +A E
Sbjct: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLP 1362
Query: 338 --------QVEWENAELR--------------------------GQLLGVTQERDSALRK 363
Q E AE R G+L+ + Q+ R
Sbjct: 1363 AKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422
Query: 364 SQGLQSKLESLEQVLKHM-----------REVAQR----RQQLEVEHEQARLSLREKQEE 408
+Q L+++ S + L + R + +R RQ LEVE +QAR ++
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 409 VRRLQQAQ-AEAQREHEGAVQLLE-STLDSMQARVRELEEQCRSQTEQFSLLAQ--ELQA 464
VR + + AE QRE + + LE T A+V+ LEE+ R Q E+ L AQ +L+
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 465 FR 466
F+
Sbjct: 1543 FQ 1544
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 70.9 bits (172), Expect = 1e-11
Identities = 100/329 (30%), Positives = 139/329 (42%), Gaps = 50/329 (15%)
Query: 196 LHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQA----RAGAPAPGA 251
L ++ D LL ++L L+R LR Q ETL Q R G A GA
Sbjct: 54 LQQKEKDLLLAAELGKML-LERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
Query: 252 PGEATPQE---DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEEL 308
EA E D + L LGE QR +Q +S + R E EQ R Q
Sbjct: 113 EWEARAVELEGDVEALRAQLGE----QRSEQQDSGRERARALSELSEQNLRLSQ------ 162
Query: 309 ELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 368
QL QA L E L G+ + AELR +L +S ++Q LQ
Sbjct: 163 --QLAQASQTEQELQRELDALRGQCQAQALA---GAELRTRL-------ESLQGENQMLQ 210
Query: 369 SKLESLEQVLKHMREVAQRRQ-QLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAV 427
S+ + LE ++ +RE ++ + +L+ HE+ L RE++E L++A++EA
Sbjct: 211 SRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE------ 264
Query: 428 QLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDC 487
S L +Q RV ELEE+ R Q S A LQ+ H LD + GD
Sbjct: 265 --ALSALRRLQRRVSELEEESRLQDADVS--AASLQSELAH--SLDDGDQGQGADAPGDT 318
Query: 488 P----PPPCCCSIPQPCRGSGPKDLDLPP 512
P P S PQP S P+++ PP
Sbjct: 319 PTTRSPKTRKASSPQP---SPPEEILEPP 344
Score = 51.6 bits (122), Expect = 7e-06
Identities = 92/372 (24%), Positives = 148/372 (39%), Gaps = 86/372 (23%)
Query: 81 EACLPSLGQQASS---SGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRAL------- 130
EA LG+Q S SG R E E L+ ++ + EL R L
Sbjct: 126 EALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQC 185
Query: 131 -------GELRQRCAILKEENQMLR----------KSSFPETEEKVRRLKRKNAELAVIA 173
ELR R L+ ENQML+ + E E+ RL+ + EL ++
Sbjct: 186 QAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLL- 244
Query: 174 KRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRN---------- 223
R E R L+ R E + L LR QR V L+ + L++
Sbjct: 245 -RRERREHSLELERARSEAGEALSA------LRRLQRRVSELEEESRLQDADVSAASLQS 297
Query: 224 ----------QRETLPLPPSWPPGPALQAR-AGAPAPGAPGEAT--PQEDADNLPVILGE 270
Q + P P + + R A +P P P E P++ P + E
Sbjct: 298 ELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILE 357
Query: 271 PEKEQRVQQLESELSKKRKKCESLEQE-ARKKQRRCEELELQLRQAQNENARLVEENSRL 329
EKE V +L+ E+S ++ + +SL +E R+K+ R +E + L
Sbjct: 358 -EKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQE----------------DPGEAL 400
Query: 330 SGRATEKEQVEWENAELRGQLLGVTQERDS-------ALRKSQGLQSKLESLE---QVLK 379
+++++ + EL QL V+ ERDS A+R+ L +LE+ + QV+
Sbjct: 401 HSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVI 460
Query: 380 HMREVAQRRQQL 391
+ +QR+++L
Sbjct: 461 GQQLRSQRQKEL 472
Score = 49.7 bits (117), Expect = 3e-05
Identities = 66/245 (26%), Positives = 100/245 (40%), Gaps = 41/245 (16%)
Query: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVIL--------GEPEKEQRVQQL 280
P PS+P GP G A+P D P +L G P E+ + L
Sbjct: 4 PDGPSFPSGPL------------SGGASPSGDEGFFPFVLERRDSFLGGGPGPEEP-EDL 50
Query: 281 ESELSKKRKKCESLEQEARKKQRRCEELELQLR----QAQNENARLVEENSRLSGRATEK 336
+L +K K + + R EEL QL Q RL +EN L R
Sbjct: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR-RGLAA 109
Query: 337 EQVEWEN--AELRGQLLGVTQERDSALRKSQGLQ--SKLESLEQVLKHMREVAQRRQQLE 392
EWE EL G + ALR G Q + +S + + + E++++ +L
Sbjct: 110 RGAEWEARAVELEGDV--------EALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 161
Query: 393 VEHEQARLSLREKQEEVRRLQ---QAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 449
+ QA + +E Q E+ L+ QAQA A E ++ L+ +Q+R ++LE Q R
Sbjct: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
Query: 450 SQTEQ 454
E+
Sbjct: 222 GLREE 226
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 70.1 bits (170), Expect = 2e-11
Identities = 114/443 (25%), Positives = 187/443 (42%), Gaps = 57/443 (12%)
Query: 119 GDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVI----AK 174
G R +L + E ++R A ++E +S+ ++R L+ + E A +
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQD---RSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 175 RLEERARKL---------QETNLRVEGPQWLHVRD-FDRLLRESQREVLRLQRQIALRNQ 224
RL+E+AR L + LR + RD R L E+QR++ Q ++ Q
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLES-- 282
E L S G A + A + A + +++ + + L +KEQ++ LE
Sbjct: 1197 -EAGELRRSLGEG-AKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
Query: 283 -----ELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKE 337
E + R + +E+ + +R +EL Q++ +EN RL E + L GR E
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGE 1314
Query: 338 QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRR-QQLEVEHE 396
+ E E+ R + LG+ Q R +G ++ LE + Q L +VAQR+ Q+ E E
Sbjct: 1315 RAEKES---RRETLGLRQ------RLLKG-EASLEVMRQEL----QVAQRKLQEQEGEFR 1360
Query: 397 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFS 456
L EE R ++ Q + R E ++L + ++ + +R + R+Q +
Sbjct: 1361 TRERRLLGSLEEARGTEKQQLDHARGLE--LKLEAARAEAAELGLRLSAAEGRAQGLEAE 1418
Query: 457 LLAQELQAFRLHPGPLDLLTSALDCG-SLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSP 515
L E+Q R L L SAL G LG P P P+P GS +D
Sbjct: 1419 LARVEVQR-RAAEAQLGGLRSALRRGLGLGRAPSP-----APRPVPGSPARDAPAEGSGE 1472
Query: 516 G-------RCTPKSSEPAPATLT 531
G C+P S P+P T
Sbjct: 1473 GLNSPSTLECSPGSQPPSPGPAT 1495
Score = 58.5 bits (140), Expect = 6e-08
Identities = 90/380 (23%), Positives = 154/380 (40%), Gaps = 57/380 (15%)
Query: 107 EAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKN 166
EA +A L E+ AL + L+ LR ++ + +L N
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEE-ASLQDSLSKLSALN 745
Query: 167 AELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR-EVLRLQRQIALRNQR 225
LA L +L+E ++G Q ++ E +R E LRL++++A +
Sbjct: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLE 805
Query: 226 ETLPLPPSWPPGPALQARAGAPAPGAPGEATP--QEDADNLPVILGEPEKEQ--RVQQLE 281
+L R A A + P + + L L + ++ R Q+LE
Sbjct: 806 GSL--------------RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
Query: 282 SELSKKRKKCESLEQEARKKQRRCEE---LELQLRQAQNENARLVEENSRLSGRATEKEQ 338
+ +++ E+LE+ AR+K+ +E L +QL A+ E L EE +RL EKE
Sbjct: 852 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR---LEKEA 908
Query: 339 VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMRE--------------- 383
+E E++ QL + R+ + Q L E+L L +R+
Sbjct: 909 LEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL 968
Query: 384 VAQRRQQLEVE-----------HEQARLSL-REKQEEVRRLQ----QAQAEAQREHEGAV 427
+AQ+ Q E E HE+ L REK+ R L+ Q Q++ QRE E +
Sbjct: 969 MAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL 1028
Query: 428 QLLESTLDSMQARVRELEEQ 447
LE+ + + + L+++
Sbjct: 1029 ARLEAEKEELSEEIAALQQE 1048
Score = 58.2 bits (139), Expect = 7e-08
Identities = 56/199 (28%), Positives = 92/199 (46%), Gaps = 14/199 (7%)
Query: 274 EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA 333
EQ + LE +L R + L+++ + R+ E +L QA+ E R VE R A
Sbjct: 812 EQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA---A 868
Query: 334 TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLE----QVLKHMREVAQRRQ 389
EKE + E+A L QL+ +E + ++ L+ + E+LE +V + + ++ RR+
Sbjct: 869 REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928
Query: 390 QLEVEHEQARLSLREKQEEVRRLQQ----AQAEAQREHEGAVQLLESTLDSMQARVRELE 445
QLE E + L+ E+ L+Q Q +A + E Q L QA +R
Sbjct: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR--- 985
Query: 446 EQCRSQTEQFSLLAQELQA 464
EQ + E L +E +A
Sbjct: 986 EQRAAHEEDLQRLQREKEA 1004
Score = 57.4 bits (137), Expect = 1e-07
Identities = 78/312 (25%), Positives = 127/312 (40%), Gaps = 35/312 (11%)
Query: 159 VRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQ 218
V+RL+++N E + K L E+ L+ +LR++ L D + L ++ LR Q
Sbjct: 406 VKRLEKQNLEKDQVNKDLTEKLEALE--SLRLQEQAALETEDGEGL-----QQTLRDLAQ 458
Query: 219 IALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQ 278
L + + L S A + G G+ TP P P + + +
Sbjct: 459 AVLSDSESGVQLSGSERTADA----SNGSLRGLSGQRTPS------PPRRSSPGRGRSPR 508
Query: 279 QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ 338
+ S + K+Q + +++ + +Q+ L +LS +E+
Sbjct: 509 RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTL---RKQLSDSESERRA 565
Query: 339 VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQA 398
+E + LR + G Q + A R+ Q L+S E L + ++ Q QQ E Q
Sbjct: 566 LEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE 625
Query: 399 RLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQF--- 455
R L+ QEE+RR + + E E AVQ ARVR E+ Q EQ
Sbjct: 626 REKLQAAQEELRRQRD---RLEEEQEDAVQ--------DGARVRRELERSHRQLEQLEGK 674
Query: 456 -SLLAQELQAFR 466
S+LA+EL R
Sbjct: 675 RSVLAKELVEVR 686
Score = 57.0 bits (136), Expect = 2e-07
Identities = 103/392 (26%), Positives = 164/392 (41%), Gaps = 67/392 (17%)
Query: 110 LKAKLNMSFGDRPNLELLRAL--GELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
LK L+ S LEL R GEL++ L + R++ +++V L+R+ A
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD-----REAQAQALQDRVDSLQRQVA 1694
Query: 168 ELAVIAKRLEERARKLQETNLRVEGPQWL---HVRDFDRLLRESQREV-------LRLQR 217
+ V A L+ +L +VE + VR L +S + L LQ+
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754
Query: 218 QI-ALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQR 276
+ A + R+ L +AR + + G + E AD + L E E +
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD---LELQRVEAEGQ 1811
Query: 277 VQQLESELSKKRK-------KCESLEQEARKKQRRCEELELQLRQAQNENARLVE----- 324
+QQL L ++++ + L+ E R Q R L+ L Q + E +
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
Query: 325 ENSRLSGRAT----EKEQVEW---------ENAELRGQLLGVTQERDSALRKSQGLQSKL 371
E R++ R T E+E++ E L L G E A R+ Q L++++
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 431
LEQ + QLEV+ +Q +L L Q+EV RL+ AQA+ +R LE
Sbjct: 1932 VVLEQ--------SHSPAQLEVDAQQQQLEL---QQEVERLRSAQAQTER-------TLE 1973
Query: 432 STLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
+ + + RVR LEEQ + Q L QEL+
Sbjct: 1974 ARERAHRQRVRGLEEQVSTLKGQ---LQQELR 2002
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/457 (23%), Positives = 181/457 (39%), Gaps = 84/457 (18%)
Query: 51 QLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFL 110
+L+ELR E+ +G S V E E LP+L + S
Sbjct: 789 RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS------------------ 830
Query: 111 KAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETE--EKVRR----LKR 164
+L L +L ++ + ++E + R+ + + E E+ R L +
Sbjct: 831 --------------QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 165 KNAELAVIAKRLEERARKLQE--TNLR-----VEGPQWLHVRDFDRLLRESQREVLRLQR 217
++A LAV E R L E T LR +EG + R +L E++RE L +
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQL--EARREQLEAEG 934
Query: 218 Q-------------IALRNQ----RETLPLPPSWPPGPALQARAGAPAPGAPGEATPQED 260
Q LR Q +E L +QA A A A +ED
Sbjct: 935 QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEED 994
Query: 261 ADNLPVILGEPEKEQRVQQLESELSK-----KRKKCESLEQEARKKQRRCEELELQLRQA 315
L + EKE ++LE+E ++ +R++ E L + +K+ EE+ L+Q
Sbjct: 995 LQRL-----QREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI-AALQQE 1048
Query: 316 QNENARLVEENSR--LSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLES 373
++E L E + LS + +EK + + R L ++ E + R +Q Q + S
Sbjct: 1049 RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
Query: 374 LEQVL-KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHE---GAVQL 429
L +R++ +R++ H Q +R QE+ R L + + RE E ++L
Sbjct: 1109 TVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRL 1165
Query: 430 LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
LE D ++ + E + + R E + QE R
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELR 1202
Score = 51.6 bits (122), Expect = 7e-06
Identities = 77/340 (22%), Positives = 150/340 (44%), Gaps = 57/340 (16%)
Query: 166 NAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIA-LRNQ 224
++ LA+I L +R ++Q+ R E Q L + + L +S+ E L+ Q+ LR++
Sbjct: 518 SSTLALIHSALHKRQLQVQDMRGRYEASQDL-LGTLRKQLSDSESERRALEEQLQRLRDK 576
Query: 225 RETLPLPPSWPPGPALQARAGAPAP----GAPGEATPQED---ADNLPVILGEPEK---- 273
+ A+QA A + E +E A +L V + E+
Sbjct: 577 TDG-----------AMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE 625
Query: 274 EQRVQQLESELSKKRKKCESLEQEA----RKKQRRCEELELQLRQAQNENA----RLVEE 325
+++Q + EL ++R + E +++A + +R E QL Q + + + LVE
Sbjct: 626 REKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEV 685
Query: 326 NSRLSGRATEKEQVEWENAELRGQL-----------LGVTQERD------------SALR 362
LS +++ ++ E AE+ L L +T+ R SAL
Sbjct: 686 REALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALN 745
Query: 363 KSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQRE 422
+S Q KL+ L +++ + E Q + + EQ RE+QE + L+ Q A++
Sbjct: 746 ESLA-QDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG 803
Query: 423 HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
EG++++ E ++++ ++ L + EQ + L+++L
Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
Score = 50.1 bits (118), Expect = 2e-05
Identities = 110/484 (22%), Positives = 184/484 (38%), Gaps = 93/484 (19%)
Query: 31 RGGEPSSAAPSIADTPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQ 90
R G APS A P ++ +E S G+G + P C P G Q
Sbjct: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGS----GEGLNSP-------STLECSP--GSQ 1487
Query: 91 ASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
S GPA P+L+ G LR+ L+E R+
Sbjct: 1488 PPSPGPATSPAS-------------------PDLDPEAVRGALRE---FLQELRSAQRER 1525
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR 210
E + L R+ AE+ RAR+LQ+ E + R D L Q
Sbjct: 1526 D--ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEAR----RSVDGRLSGVQA 1579
Query: 211 EVLRLQRQIALRNQRE-------TLPLPPSWPPGPA-LQARAGAPAPGAPGEATPQEDAD 262
E L LQ + R++RE L S + L+A + E + D
Sbjct: 1580 E-LALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
Query: 263 NLPVILGEPEK-----EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQN 317
L +L E E + + LE EL + R E +A+ Q R + L+ Q+ ++
Sbjct: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1698
Query: 318 ENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQ-------------ERDSALRKS 364
+ L RL+G + E+ E LR ++ G+T+ +++ L+K+
Sbjct: 1699 KAGTLQLTVERLNGALAKVEESE---GALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA 1755
Query: 365 --------QGLQSKLESLEQVLKHMREVAQRRQQ-----------LEVEHEQARLSLREK 405
Q LQ +L++ Q L R+ + + LE++ +A L++
Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815
Query: 406 QEEVRRLQQAQAEAQ---REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
+E +R+ Q+ +A A ++ + +LL+ L S+Q + +LE + R L ++
Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDR 1875
Query: 463 QAFR 466
A R
Sbjct: 1876 VALR 1879
Score = 44.7 bits (104), Expect = 8e-04
Identities = 82/358 (22%), Positives = 141/358 (39%), Gaps = 56/358 (15%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETN-- 187
LG LR++ + + E + L EE+++RL+ K + + ++L+ N
Sbjct: 549 LGTLRKQLSDSESERRAL--------EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600
Query: 188 LRVEGPQWLHVRDFDRLLRESQREVLRLQR------QIALRNQRETLPLPPSWPPGPALQ 241
L E H + + Q E LR +R Q LR QR+ L +
Sbjct: 601 LSREKSNLAHSLQ----VAQQQAEELRQEREKLQAAQEELRRQRDRLE-----------E 645
Query: 242 ARAGAPAPGAPGEATPQEDADNLPVILGE----PEKEQRVQQLESELSKKRKKCESLEQE 297
+ A GA + L + G+ ++ V++ S + +R ++ + E
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 298 ARKKQRRCE----ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 353
+ + E ELEL + + + E A L + S+LS Q + + L QL
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL--- 762
Query: 354 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARL----SLREKQEEV 409
+E SAL Q + EQ RE +R ++L +E E AR SLR ++
Sbjct: 763 -EEEKSAL------QGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
Query: 410 RRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEE---QCRSQTEQFSLLAQELQA 464
L+Q + E + L + R +ELE+ + + Q E A+E +A
Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA 873
Score = 42.4 bits (98), Expect = 0.004
Identities = 81/370 (21%), Positives = 154/370 (41%), Gaps = 99/370 (26%)
Query: 140 LKEENQMLRKSSFPETEEKVRRLKRKNAELAV----IAKRLEERARKLQETNLRVEGPQW 195
L+EENQ+L++ E+ + + + + ELA+ +++RLE+ A +L+ L + P+
Sbjct: 79 LQEENQLLQQE-LSRVEDLLAQSRAERDELAIKYNAVSERLEQ-ALRLEPGELETQEPRG 136
Query: 196 LHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEA 255
L VR L R+ Q E +R++ +
Sbjct: 137 L-VRQSVELRRQLQEEQASYRRKLQAYQE------------------------------- 164
Query: 256 TPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKK-----QRRCEELE- 309
G+ + Q VQ+L+ ++ + +K+C LEQ+ ++ Q+R + E
Sbjct: 165 -------------GQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEH 211
Query: 310 --------LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT------- 354
++L + Q +A L + N+ L + +Q N L + VT
Sbjct: 212 SQDLESALIRLEEEQQRSASLAQVNAML---REQLDQAGSANQALSEDIRKVTNDWTRCR 268
Query: 355 ---QERDSALRKSQ--------GLQSKLESL-EQVLKHMREVAQ-----RRQQLEVEHEQ 397
+ R++A R+ + S+L L QV+ R V++ R L++ E
Sbjct: 269 KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGEL 328
Query: 398 ARLSLREKQEEV-----RRLQQAQAEAQREHEGAVQL-LESTLDSMQARVREL-EEQCRS 450
AR S ++ + RL +++AEA E + +Q LE L R ++L ++Q +S
Sbjct: 329 ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQS 388
Query: 451 QTEQFSLLAQ 460
++ L A+
Sbjct: 389 DLDKADLSAR 398
Score = 38.1 bits (87), Expect = 0.078
Identities = 40/136 (29%), Positives = 57/136 (41%), Gaps = 18/136 (13%)
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
L Q EN L +E SR+ + E EL + V++ + ALR G +L
Sbjct: 76 LLSLQEENQLLQQELSRVEDLLAQSRA---ERDELAIKYNAVSERLEQALRLEPG---EL 129
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 431
E+ E + V RRQ L+E+Q RR QA E Q+ VQ L+
Sbjct: 130 ETQEPRGLVRQSVELRRQ------------LQEEQASYRRKLQAYQEGQQRQAQLVQRLQ 177
Query: 432 STLDSMQARVRELEEQ 447
+ + R ELE+Q
Sbjct: 178 GKILQYKKRCSELEQQ 193
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 69.7 bits (169), Expect = 2e-11
Identities = 97/376 (25%), Positives = 133/376 (35%), Gaps = 96/376 (25%)
Query: 997 VRTMSPHGESADSIPAPITPALAPA-----------------SLPARVSCPSPHPSPEAR 1039
V + P G + + PAP+ P AP+ S+P+ PS P P A
Sbjct: 635 VPPLQPMGPTCPT-PAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSA- 692
Query: 1040 APLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDP------------ 1087
P+ SA PGP ++ L P PP P P A GS+EDP
Sbjct: 693 GPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPG-PENHRA-GSNEDPILAPSGTPPPTI 750
Query: 1088 ----------PAPC----SQEEAGAAVLGTSEERTASTSTLGE-------KDPGPAAPSL 1126
P P +EEA + + S + E P A P
Sbjct: 751 PPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPP 810
Query: 1127 AKQEAEWTAGEACPASSSTQGARAQQAP------------------NTEMCQGGDPGSGL 1168
TA PA + A P ++ G PG G
Sbjct: 811 IAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGG 870
Query: 1169 RPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAG 1228
P E++ L V +NS SD +EEEEEEEEEEEEE F+++
Sbjct: 871 PPALEED----LTVININS----------SDEEEEEEEEEEEEEEEEEEEEEDFEEE--- 913
Query: 1229 NSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKS 1288
+ + + F E + +EE E+ E + ++ EEEEE EE E+ E
Sbjct: 914 -------EEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG 966
Query: 1289 GAGCSSRDPGPPEPAL 1304
AG + PP P L
Sbjct: 967 TAGGEVEEGAPPPPTL 982
Score = 41.2 bits (95), Expect = 0.009
Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 10/127 (7%)
Query: 229 PLPPSWPPGPALQARAGAPAP-----GAPGEATPQEDADNLPVIL-----GEPEKEQRVQ 278
PLPP PP P + P P G PG P ++L VI E E+E+ +
Sbjct: 838 PLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEE 897
Query: 279 QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ 338
+ E E ++ + E E++ + EE E + + E +EE E+E
Sbjct: 898 EEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEEL 957
Query: 339 VEWENAE 345
E E+ E
Sbjct: 958 EEVEDLE 964
Score = 39.3 bits (90), Expect = 0.035
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 2/73 (2%)
Query: 913 TLPAG--PPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIME 970
TLP PP++P VQ EP P PG+L+ P T + G + A+ + G+ E
Sbjct: 981 TLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVERE 1040
Query: 971 VASPTAGSVLVEL 983
SP AG EL
Sbjct: 1041 GESPAAGPPPQEL 1053
Score = 35.4 bits (80), Expect = 0.50
Identities = 44/149 (29%), Positives = 51/149 (34%), Gaps = 33/149 (22%)
Query: 1004 GESADSIPAPIT--PALAPASLPARVSCPSPHPSP------------EAR--------AP 1041
GE + P P T PAL P P +V P P P P E R AP
Sbjct: 970 GEVEEGAPPPPTLPPALPPPESPPKVQ-PEPEPEPGLLLEVEEPGTEEERGADTAPTLAP 1028
Query: 1042 LASASPGP--GDPSSPLQHPAPLG-TQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGA 1098
A S G + SP P P +E P APP E GS + P P + E
Sbjct: 1029 EALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAE--- 1085
Query: 1099 AVLGTSEERTASTSTLGEKDPGPAAPSLA 1127
E L EK+ A LA
Sbjct: 1086 ----EEMETETEAEALQEKEQDDTAAMLA 1110
Score = 32.0 bits (71), Expect = 5.6
Identities = 37/173 (21%), Positives = 63/173 (36%), Gaps = 11/173 (6%)
Query: 392 EVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ 451
E E E+ E++EE ++ + + + E + E + + ELEE+ +
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949
Query: 452 TEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLP 511
E+ +E++ L+ T+ G + + PPP P S PK P
Sbjct: 950 DEEEEEELEEVE-------DLEFGTAG---GEVEEGAPPPPTLPPALPPPESPPKVQPEP 999
Query: 512 PGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPE 564
PG + EP G E+L + E SP + P P+
Sbjct: 1000 EPEPGLLL-EVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQ 1051
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 68.9 bits (167), Expect = 4e-11
Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 29/256 (11%)
Query: 216 QRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQ 275
QR++ L+ Q E P P P LQ P P + PQ+D L + EK Q
Sbjct: 86 QRELQLQ-QLEQQPEPQQQPQHEQLQQ----PQPHLELQQQPQQDGQQQLSQL-QQEKHQ 139
Query: 276 RV--QQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA 333
V Q+L+ EL ++ + L+ + ++Q+R ++ + QL+ Q + +++++ +L +
Sbjct: 140 SVHHQELKPELQLMHQQ-QQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 334 TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEV 393
E++ + Q++ L++ Q LQ + + +Q + +E Q++QQL +
Sbjct: 199 QEQQ---------------LLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLL 243
Query: 394 EHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
+Q +L Q+++ + QQAQ + Q + QL + L Q ++++ ++Q Q +
Sbjct: 244 LQQQGQL-----QQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQ 298
Query: 454 QFSLLAQELQAFRLHP 469
Q L Q+LQ L P
Sbjct: 299 QEQLQQQQLQPPPLEP 314
Score = 62.0 bits (149), Expect = 5e-09
Identities = 50/197 (25%), Positives = 109/197 (55%), Gaps = 12/197 (6%)
Query: 272 EKEQRVQQLESEL-SKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLS 330
+++QR+QQ + +L +++ ++ + L+Q+ + +Q+ E+ LQ +Q Q + +L+++ +L
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQ 224
Query: 331 GRATEKEQVEWENAELRGQLLGVTQE---RDSALRKSQG-LQSKLESLEQVLKHMREVAQ 386
+ +++Q E + + QLL + Q+ + L++ Q LQ +L +Q + + Q
Sbjct: 225 QQQFQQQQ---EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQ 281
Query: 387 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEE 446
+++QL+ + +Q L +++Q + ++LQ E + E E ++L+ L S Q ELE+
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ----ELEQ 337
Query: 447 QCRSQTEQFSLLAQELQ 463
Q + Q L Q+ Q
Sbjct: 338 QRQELERQQELERQQEQ 354
Score = 57.8 bits (138), Expect = 9e-08
Identities = 79/398 (19%), Positives = 173/398 (43%), Gaps = 74/398 (18%)
Query: 88 GQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQML 147
G S G ++EE + + S RP + E+ + + E Q+
Sbjct: 38 GPDTLSGGSGGSESQEEE-----EPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQ 92
Query: 148 RKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLR- 206
+ PE +++ + + + + + ++ ++ + Q + L+ E Q +H ++ L+
Sbjct: 93 QLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQL 152
Query: 207 ---ESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADN 263
+ Q + ++Q Q L+ Q+E L +A Q+
Sbjct: 153 MHQQQQLQPQQVQEQQRLQQQQEQLQTQ----------------------QAQEQQVLQQ 190
Query: 264 LPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLV 323
+ + +++Q +QQ + +L ++ + L+Q+ + +Q++ ++ + QL+Q Q L+
Sbjct: 191 QEQLQQQVQEQQLLQQQQEQLQQQ----QLLQQQEQLQQQQFQQQQEQLQQQQQ--LLLL 244
Query: 324 EENSRLSGRATEKEQ-------VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL-- 374
++ +L + +++Q +E + A+L+ QLL QE+ ++ Q LQ + E L
Sbjct: 245 QQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQ 304
Query: 375 ---------------------------EQVLKHMREVAQRRQQLEVEHEQARLSLREKQE 407
EQ L+ R+ +R+Q+LE + EQ +L L+ QE
Sbjct: 305 QQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLK-LQE 363
Query: 408 EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELE 445
E+++L+Q + Q++ E LE T + A+ +E++
Sbjct: 364 ELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQ 401
Score = 53.9 bits (128), Expect = 1e-06
Identities = 61/261 (23%), Positives = 122/261 (46%), Gaps = 29/261 (11%)
Query: 233 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292
S P PA+ A GA E P + L + +PE +Q+ Q +L + + E
Sbjct: 62 SSPQRPAVSAPVGASEIAE--ETRPGQRELQLQQLEQQPEPQQQPQH--EQLQQPQPHLE 117
Query: 293 SLEQEARKKQRRCEELELQLRQAQNENA-----RLVEENSRLSGRATEKEQVEWENAELR 347
+Q + Q++ +L+ + Q+ + +L+ + +L + +++Q + E
Sbjct: 118 LQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQE-- 175
Query: 348 GQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARL------- 400
QL + L++ + LQ +++ +Q+L+ +E Q+ QQL + EQ +
Sbjct: 176 -QLQTQQAQEQQVLQQQEQLQQQVQE-QQLLQQQQEQLQQ-QQLLQQQEQLQQQQFQQQQ 232
Query: 401 -SLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 456
L+++Q+ + QQ Q + Q + QL + L+ QA++++ L++Q + Q +Q
Sbjct: 233 EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQ 292
Query: 457 LLAQ----ELQAFRLHPGPLD 473
L Q +LQ +L P PL+
Sbjct: 293 QLLQQQQEQLQQQQLQPPPLE 313
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 68.9 bits (167), Expect = 4e-11
Identities = 116/473 (24%), Positives = 210/473 (44%), Gaps = 71/473 (15%)
Query: 33 GEPSSAAPSI--------ADTPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACL 84
GE S+A+ S+ A +PPAA + + + ++ + G G DPE A
Sbjct: 511 GEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEE-LGPGQEE---AEDPEEKVAVS 566
Query: 85 PS--LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAI--L 140
P+ + + S+ P P ++ EA LKA E + + E QR +
Sbjct: 567 PTPPVSPEVRSTEPVA--PPEQLSEAALKAME----------EAVAQVLEQDQRHLLESK 614
Query: 141 KEENQMLRKSSFPETEEKVRRL-KRKNAELAVIAKRL-----EERARKLQETNLRVEGPQ 194
+E+ Q LR+ E EE++ RL ++K L+ + +RL EE AR +E + R+
Sbjct: 615 QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLS--- 671
Query: 195 WLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGE 254
WL + + ++ + +R +++ +L+ RE L +L+ + E
Sbjct: 672 WLRAQV--QSSTQADEDQIRAEQEASLQKLREELESQQK-AERASLEQKNRQMLEQLKEE 728
Query: 255 ATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC-ESLEQE-ARKKQRRCEELELQL 312
E ++ + KE+ +QQL +L +RK+ +LE+E + + +R C LE +
Sbjct: 729 IEASEKSEQAAL---NAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLE 372
R+ + + ++E A +KE+ + + LG + R +KS +
Sbjct: 786 REVVSSLQKKIQE-------AQQKEEAQLQKC------LGQVEHR--VHQKSYHVAGYEH 830
Query: 373 SLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQL--L 430
L +L+ ++RQ++E EHE+ ++E+ ++V + Q EA+ + A L L
Sbjct: 831 ELSSLLR------EKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHL 884
Query: 431 ESTLDSMQ-ARVRELEEQCRSQTEQFSLLAQ--ELQAFRLHPGPLDLLTSALD 480
L+ +Q A RELE + Q ++ L + Q +L LDL T A D
Sbjct: 885 TGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
Score = 47.4 bits (111), Expect = 1e-04
Identities = 90/399 (22%), Positives = 166/399 (41%), Gaps = 51/399 (12%)
Query: 102 EDEEVEAFLKAKLNMSFGDRPN-LELLRAL-GELRQRCAILKEENQMLRKSSFPETEEKV 159
++E + KA+ +R ELL L GEL + + E + +R+ E+
Sbjct: 855 KEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLR 914
Query: 160 RRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI 219
RR + + +L + LE RA+ ++ +E + R ++++L +QRQ+
Sbjct: 915 RRHREQERKLQDLELDLETRAKDVKARLALLEVQE--------ETARREKQQLLDVQRQV 966
Query: 220 ALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQ 279
AL+++ T L+ +E D L + + E +V
Sbjct: 967 ALKSEEATAT-------HQQLEEAQKEHTHLLQSNQQLREILDELQA--RKLKLESQVDL 1017
Query: 280 LESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 339
L+++ + +K SLE EA+KKQ E+ VEEN+ A+ +
Sbjct: 1018 LQAQSQQLQKHFSSLEAEAQKKQHLLREV-------------TVEENN-----ASPHFEP 1059
Query: 340 EWENAELRGQLLGVTQERDSALRKSQGLQS-KLESL-EQVLKHM--REVAQRRQQLEVEH 395
+ +LR + LG Q ++ + SQ + L+SL + H+ E R E
Sbjct: 1060 DLHIEDLR-KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLV 1118
Query: 396 EQARLSLREKQEEVRRLQQ------AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 449
+Q R S+R +Q ++ QQ A A+ + ++ LE +++ R L+E
Sbjct: 1119 QQTR-SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
Query: 450 SQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCP 488
+ + +LL ++ + +L+ L A D G+LG P
Sbjct: 1178 AMRKGHNLLKKKEE--KLNQLESSLWEEASDEGTLGGSP 1214
Score = 36.2 bits (82), Expect = 0.30
Identities = 88/425 (20%), Positives = 162/425 (38%), Gaps = 51/425 (12%)
Query: 54 ELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSL---GQQASSSGPAC-QRPEDEEVEAF 109
E + + S G P + P GA++ L S G+Q S + P ++ E+E+ E
Sbjct: 264 EEKKDVSLDSDAAGPPTPCKPSSP-GADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPK 322
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAEL 169
+ L D E +A + + E R+ + E ++K L+ +++
Sbjct: 323 ICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD- 381
Query: 170 AVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR----EVLRLQRQIALRNQR 225
A + E ++ Q ++ P+ H DF R S+ +VL A R +
Sbjct: 382 ASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQ 441
Query: 226 ETLPLPPS-----------WPPGPALQARAGAPAP------GAPGEATPQEDADNLPVIL 268
+ L + L+ R P P P +E+ P
Sbjct: 442 QPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPE-- 499
Query: 269 GEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQN-----ENARLV 323
G+PE ++ + E + + ++A CE+ + Q QA+ E A
Sbjct: 500 GQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDP 559
Query: 324 EENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMRE 383
EE +S +V + L ++AL+ + ++ + LEQ +H+ E
Sbjct: 560 EEKVAVSPTPPVSPEVRSTEPVAPPEQLS-----EAALKAME--EAVAQVLEQDQRHLLE 612
Query: 384 VAQRRQQLEVEHEQARLSL-REKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVR 442
Q + Q Q R L +E++EE+ RL Q + ++ + L+ ++ +AR+R
Sbjct: 613 SKQEKMQ------QLREKLCQEEEEEILRLHQ---QKEQSLSSLRERLQKAIEEEEARMR 663
Query: 443 ELEEQ 447
E E Q
Sbjct: 664 EEESQ 668
Score = 33.5 bits (75), Expect = 1.9
Identities = 88/417 (21%), Positives = 149/417 (35%), Gaps = 65/417 (15%)
Query: 192 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 251
G Q + D+D S++E+L R+I + P P AR G AP
Sbjct: 9 GDQLVLEEDYDETYIPSEQEILEFAREIG---------IDPIKEPELMWLAREGIVAP-L 58
Query: 252 PGEATPQEDAD---------NLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQ 302
PGE P +D N + P ++ + L + K +++++ +KK+
Sbjct: 59 PGEWKPCQDITGDIYYFNFANGQSMWDHP-CDEHYRSLVIQERAKLSTSGAIKKKKKKKE 117
Query: 303 RRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALR 362
++ ++ + + + L + L G A + V+ + LRG + +L
Sbjct: 118 KKDKKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRG-------SQSVSLG 170
Query: 363 KSQGLQSKLESLEQVLKHMREVAQRRQQL-EVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
S +L L + ++ A + L + ++ LSL EE + +++ Q
Sbjct: 171 SSVESGRQLGELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQS 230
Query: 422 EHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDC 481
H + L LD + A + E + +T Q P + +LD
Sbjct: 231 VHSSSEPLRNLHLD-IGALGGDFEYEESLRTSQ----------------PEEKKDVSLDS 273
Query: 482 GSLGDCPPPPCCCSIP------QPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPR 535
+ G PP PC S P G G + PG P + + SEP P+
Sbjct: 274 DAAG--PPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPK 331
Query: 536 RTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASE---VEELEADSVSLLPAAPEGS 589
++ + SE S K P VD E EE + A EGS
Sbjct: 332 ---------ADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGS 379
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 68.9 bits (167), Expect = 4e-11
Identities = 91/407 (22%), Positives = 171/407 (42%), Gaps = 48/407 (11%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
L ++ + S + E EA K +S R E L A EL + +LK E +
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLA-RALEEALEAKEELERTNKMLKAEMED 1515
Query: 147 LRKS------SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
L S + E E+ R L+ + E+ + LE+ + ++ LR+E
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 201 FDRLL--RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQ 258
F+R L R+ Q E R Q Q L L AL A A G + Q
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELE---DERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 259 EDADNLPVILGEPEKEQRVQQLES-------ELSKKRKKCESLEQEARKKQRRCEELELQ 311
D+ I G E +++++L++ EL R + + A++ +++ + LE
Sbjct: 1633 ADS----AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
L Q Q + L+ ++Q + E EL +L R++ + + L++++
Sbjct: 1689 LMQLQED----------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 372 ESLEQVLKH-----------MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LE+ L+ +R+ Q+ +QL E R + ++ + ++L++ E +
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 421 ---REHEGAVQL-LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
E EGAV+ +ST+ +++A++ +LEEQ + + + L+
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845
Score = 67.0 bits (162), Expect = 2e-10
Identities = 90/378 (23%), Positives = 170/378 (44%), Gaps = 63/378 (16%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETE-----EKVR-RLKRKNAELAVIAKRLEERARKL 183
L EL Q+ + L EE +L++ ETE E++R RL K EL I +E R +
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 184 QETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ-RETLPLPPSWPPGPALQA 242
++ +++ + ++ +++L L+ Q+ R+ L L +
Sbjct: 935 EDRGQQLQAER-----------KKMAQQMLDLEEQLEEEEAARQKLQLE---------KV 974
Query: 243 RAGAPAPGAPGEATPQEDADNLPVILGEPEK--EQRVQQLESELSKKRKKCESLEQEARK 300
A A E +D +N L + K E+R+ L + L+++ +K ++L + K
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNK---LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATE-KEQV---EWENAELRGQLLGVTQE 356
+ ELE++L++ + L + +L G A++ EQ+ + + AEL+ QL +E
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 357 RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQL--EVEHEQARLSLREKQ-----EEV 409
+AL + L ++ LK +RE+ L +++ E+A + EKQ EE+
Sbjct: 1092 LQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 410 RRLQ----------QAQAEAQREHEGAVQLLESTLD----SMQARVRELEEQCRSQTEQF 455
L+ Q E + + E V +L+ LD S +A+V+E+ ++ E+
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE- 1207
Query: 456 SLLAQELQAFRLHPGPLD 473
L ++L+ F+ LD
Sbjct: 1208 --LTEQLEQFKRAKANLD 1223
Score = 62.8 bits (151), Expect = 3e-09
Identities = 70/325 (21%), Positives = 136/325 (41%), Gaps = 20/325 (6%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
+EE ++ +T+E+ ++ + + EL +L E LQE L+ E + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAEE 908
Query: 201 FDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPG--EATPQ 258
L ++E+ + ++ R + E G LQA A E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEE-------DRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 259 EDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE 318
E+A + L + E ++++LE E+ + L +E + + R +L L + + +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 319 NARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
L + ++ +E E + + R QE + RK +G S EQ+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR-------QELEKLKRKLEGDASDFH--EQIA 1072
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQ 438
++A+ + QL + E+ + +L +E+ + A + RE EG + L+ LDS +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSER 1131
Query: 439 ARVRELEEQCRSQTEQFSLLAQELQ 463
A + E+Q R E+ L EL+
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELE 1156
Score = 60.8 bits (146), Expect = 1e-08
Identities = 90/425 (21%), Positives = 177/425 (41%), Gaps = 62/425 (14%)
Query: 110 LKAKLNMSFGDRPNLELLRALGE-----LRQRCAILKEENQMLRK-------------SS 151
L+ +L R L+L + E L ++ ++N L K ++
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 152 FPETEEKVRRL-KRKN------AELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL 204
E EEK + L K KN +EL V K+ E+ ++L++ ++EG DF
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD----ASDFHEQ 1070
Query: 205 LRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP-QEDADN 263
+ + Q ++ L+ Q+A + + E A + A G + QED D+
Sbjct: 1071 IADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 264 LPVILGEPEKEQRV--QQLES----------------ELSKKRKK-----CESLEQEARK 300
+ EK++R ++LE+ EL KR++ ++L++E R
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ-VEWENAELRGQLLGVTQERDS 359
+ + +E+ + QA E +E+ R + +Q +E ENA+L G+L + Q +
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 360 ALRKSQGLQSKLESLEQVL----KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
K + L+++++ L+ + E+ + +L+ E E L E + + +L +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 416 QAEAQREHEGAVQLLESTLD---SMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPL 472
A + + +LL+ ++ ++R+LEE+ S +Q + Q H L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 473 DLLTS 477
++ S
Sbjct: 1370 NIQLS 1374
Score = 55.8 bits (133), Expect = 4e-07
Identities = 91/431 (21%), Positives = 178/431 (41%), Gaps = 73/431 (16%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRL 162
DEE+EA + ++S + + + L + L+E + +K E E ++
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK----EIENLTQQY 1408
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVEGPQWL------HVRDFDRLLRE----SQREV 212
+ K A + K ++L + + ++ + L R FD+LL E S +
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE---DADNLPVILG 269
R A ++ET L + AL+A+ +A ++ D++ +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 270 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQR---RCE----------ELELQLRQAQ 316
E EK +R LE+++ + + + E LE E + + R E E +LQ R Q
Sbjct: 1529 ELEKSKRA--LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 317 NENAR-------------LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRK 363
NE R L +E + + A K+++E + +L Q + R+ A+++
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
Query: 364 SQGLQSKLESLEQVLKHMR----EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ LQ++++ ++ L+ R E+ ++ E + + L + QE++ ++A+ +A
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 420 QREHEGAVQLLESTLDS----------MQARVRELEEQC--------------RSQTEQF 455
E E + L S+L ++AR+ +LEE+ R T+Q
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 456 SLLAQELQAFR 466
L+ EL R
Sbjct: 1767 EQLSNELATER 1777
Score = 54.3 bits (129), Expect = 1e-06
Identities = 88/392 (22%), Positives = 166/392 (42%), Gaps = 51/392 (13%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS---SFPETEEKV 159
++E++A AKL + N++ L+ G+ + E+N+ R+ E E ++
Sbjct: 1552 EDELQATEDAKLRLEV----NMQALK--GQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 160 RRLKRKNAELAVIAKRLEERARKLQ-ETNLRVEGPQWL--HVRDFDRLLRESQREV--LR 214
+++ A A K+LE + L+ + + ++G + +R +++ QRE+ R
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 215 LQRQIALRNQRETLPLPPSWPPG--PALQARAGAPAPGAPGEATPQEDADNLPVILG--- 269
R +E S + A A + +E A+ L L
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 270 --EPEK---EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ-----NEN 319
+ EK E R+ QLE EL +++ E++ RK ++ E+L +L + NE+
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785
Query: 320 AR--LVEENSRLSGRATEKE------------QVEWENAELRGQLLGVTQERDSALRKSQ 365
AR L +N L + E E +E + A+L Q+ +E+ +A + +
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845
Query: 366 GLQSKL-ESLEQVLKHMREVAQRRQQLEVEH---EQARLSLREKQEEVRRLQQAQAEAQR 421
KL E L QV + Q ++Q E + +Q + L E +EE +R+ + + QR
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 422 EHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
E + A + + ++M V L+ + R E
Sbjct: 1906 ELDEATE----SNEAMGREVNALKSKLRRGNE 1933
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/104 (23%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 362 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
R+ + +Q+K + L++ + ++ ++LE +H Q QE+++ + AEA+
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 422 EH---EGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
Q LE L M+AR+ E E++ + + +AQ++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 68.9 bits (167), Expect = 4e-11
Identities = 91/407 (22%), Positives = 171/407 (42%), Gaps = 48/407 (11%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
L ++ + S + E EA K +S R E L A EL + +LK E +
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLA-RALEEALEAKEELERTNKMLKAEMED 1522
Query: 147 LRKS------SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
L S + E E+ R L+ + E+ + LE+ + ++ LR+E
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 201 FDRLL--RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQ 258
F+R L R+ Q E R Q Q L L AL A A G + Q
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELE---DERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 259 EDADNLPVILGEPEKEQRVQQLES-------ELSKKRKKCESLEQEARKKQRRCEELELQ 311
D+ I G E +++++L++ EL R + + A++ +++ + LE
Sbjct: 1640 ADS----AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
L Q Q + L+ ++Q + E EL +L R++ + + L++++
Sbjct: 1696 LMQLQED----------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 372 ESLEQVLKH-----------MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LE+ L+ +R+ Q+ +QL E R + ++ + ++L++ E +
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 421 ---REHEGAVQL-LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
E EGAV+ +ST+ +++A++ +LEEQ + + + L+
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852
Score = 67.0 bits (162), Expect = 2e-10
Identities = 90/378 (23%), Positives = 170/378 (44%), Gaps = 63/378 (16%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETE-----EKVR-RLKRKNAELAVIAKRLEERARKL 183
L EL Q+ + L EE +L++ ETE E++R RL K EL I +E R +
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 184 QETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ-RETLPLPPSWPPGPALQA 242
++ +++ + ++ +++L L+ Q+ R+ L L +
Sbjct: 942 EDRGQQLQAER-----------KKMAQQMLDLEEQLEEEEAARQKLQLE---------KV 981
Query: 243 RAGAPAPGAPGEATPQEDADNLPVILGEPEK--EQRVQQLESELSKKRKKCESLEQEARK 300
A A E +D +N L + K E+R+ L + L+++ +K ++L + K
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNK---LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATE-KEQV---EWENAELRGQLLGVTQE 356
+ ELE++L++ + L + +L G A++ EQ+ + + AEL+ QL +E
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 357 RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQL--EVEHEQARLSLREKQ-----EEV 409
+AL + L ++ LK +RE+ L +++ E+A + EKQ EE+
Sbjct: 1099 LQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 410 RRLQ----------QAQAEAQREHEGAVQLLESTLD----SMQARVRELEEQCRSQTEQF 455
L+ Q E + + E V +L+ LD S +A+V+E+ ++ E+
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE- 1214
Query: 456 SLLAQELQAFRLHPGPLD 473
L ++L+ F+ LD
Sbjct: 1215 --LTEQLEQFKRAKANLD 1230
Score = 62.8 bits (151), Expect = 3e-09
Identities = 70/325 (21%), Positives = 136/325 (41%), Gaps = 20/325 (6%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
+EE ++ +T+E+ ++ + + EL +L E LQE L+ E + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAEE 915
Query: 201 FDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPG--EATPQ 258
L ++E+ + ++ R + E G LQA A E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEE-------DRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 259 EDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE 318
E+A + L + E ++++LE E+ + L +E + + R +L L + + +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 319 NARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
L + ++ +E E + + R QE + RK +G S EQ+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR-------QELEKLKRKLEGDASDFH--EQIA 1079
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQ 438
++A+ + QL + E+ + +L +E+ + A + RE EG + L+ LDS +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSER 1138
Query: 439 ARVRELEEQCRSQTEQFSLLAQELQ 463
A + E+Q R E+ L EL+
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELE 1163
Score = 60.8 bits (146), Expect = 1e-08
Identities = 90/425 (21%), Positives = 177/425 (41%), Gaps = 62/425 (14%)
Query: 110 LKAKLNMSFGDRPNLELLRALGE-----LRQRCAILKEENQMLRK-------------SS 151
L+ +L R L+L + E L ++ ++N L K ++
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 152 FPETEEKVRRL-KRKN------AELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL 204
E EEK + L K KN +EL V K+ E+ ++L++ ++EG DF
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD----ASDFHEQ 1077
Query: 205 LRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP-QEDADN 263
+ + Q ++ L+ Q+A + + E A + A G + QED D+
Sbjct: 1078 IADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 264 LPVILGEPEKEQRV--QQLES----------------ELSKKRKK-----CESLEQEARK 300
+ EK++R ++LE+ EL KR++ ++L++E R
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ-VEWENAELRGQLLGVTQERDS 359
+ + +E+ + QA E +E+ R + +Q +E ENA+L G+L + Q +
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 360 ALRKSQGLQSKLESLEQVL----KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
K + L+++++ L+ + E+ + +L+ E E L E + + +L +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 416 QAEAQREHEGAVQLLESTLD---SMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPL 472
A + + +LL+ ++ ++R+LEE+ S +Q + Q H L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 473 DLLTS 477
++ S
Sbjct: 1377 NIQLS 1381
Score = 55.8 bits (133), Expect = 4e-07
Identities = 91/431 (21%), Positives = 178/431 (41%), Gaps = 73/431 (16%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRL 162
DEE+EA + ++S + + + L + L+E + +K E E ++
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK----EIENLTQQY 1415
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVEGPQWL------HVRDFDRLLRE----SQREV 212
+ K A + K ++L + + ++ + L R FD+LL E S +
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE---DADNLPVILG 269
R A ++ET L + AL+A+ +A ++ D++ +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 270 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQR---RCE----------ELELQLRQAQ 316
E EK +R LE+++ + + + E LE E + + R E E +LQ R Q
Sbjct: 1536 ELEKSKRA--LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 317 NENAR-------------LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRK 363
NE R L +E + + A K+++E + +L Q + R+ A+++
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
Query: 364 SQGLQSKLESLEQVLKHMR----EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ LQ++++ ++ L+ R E+ ++ E + + L + QE++ ++A+ +A
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 420 QREHEGAVQLLESTLDS----------MQARVRELEEQC--------------RSQTEQF 455
E E + L S+L ++AR+ +LEE+ R T+Q
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 456 SLLAQELQAFR 466
L+ EL R
Sbjct: 1774 EQLSNELATER 1784
Score = 54.3 bits (129), Expect = 1e-06
Identities = 88/392 (22%), Positives = 166/392 (42%), Gaps = 51/392 (13%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS---SFPETEEKV 159
++E++A AKL + N++ L+ G+ + E+N+ R+ E E ++
Sbjct: 1559 EDELQATEDAKLRLEV----NMQALK--GQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 160 RRLKRKNAELAVIAKRLEERARKLQ-ETNLRVEGPQWL--HVRDFDRLLRESQREV--LR 214
+++ A A K+LE + L+ + + ++G + +R +++ QRE+ R
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 215 LQRQIALRNQRETLPLPPSWPPG--PALQARAGAPAPGAPGEATPQEDADNLPVILG--- 269
R +E S + A A + +E A+ L L
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 270 --EPEK---EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ-----NEN 319
+ EK E R+ QLE EL +++ E++ RK ++ E+L +L + NE+
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792
Query: 320 AR--LVEENSRLSGRATEKE------------QVEWENAELRGQLLGVTQERDSALRKSQ 365
AR L +N L + E E +E + A+L Q+ +E+ +A + +
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852
Query: 366 GLQSKL-ESLEQVLKHMREVAQRRQQLEVEH---EQARLSLREKQEEVRRLQQAQAEAQR 421
KL E L QV + Q ++Q E + +Q + L E +EE +R+ + + QR
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1912
Query: 422 EHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
E + A + + ++M V L+ + R E
Sbjct: 1913 ELDEATE----SNEAMGREVNALKSKLRRGNE 1940
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/104 (23%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 362 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
R+ + +Q+K + L++ + ++ ++LE +H Q QE+++ + AEA+
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 422 EH---EGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
Q LE L M+AR+ E E++ + + +AQ++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 68.9 bits (167), Expect = 4e-11
Identities = 91/407 (22%), Positives = 171/407 (42%), Gaps = 48/407 (11%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
L ++ + S + E EA K +S R E L A EL + +LK E +
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLA-RALEEALEAKEELERTNKMLKAEMED 1522
Query: 147 LRKS------SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
L S + E E+ R L+ + E+ + LE+ + ++ LR+E
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 201 FDRLL--RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQ 258
F+R L R+ Q E R Q Q L L AL A A G + Q
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELE---DERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 259 EDADNLPVILGEPEKEQRVQQLES-------ELSKKRKKCESLEQEARKKQRRCEELELQ 311
D+ I G E +++++L++ EL R + + A++ +++ + LE
Sbjct: 1640 ADS----AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
L Q Q + L+ ++Q + E EL +L R++ + + L++++
Sbjct: 1696 LMQLQED----------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 372 ESLEQVLKH-----------MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LE+ L+ +R+ Q+ +QL E R + ++ + ++L++ E +
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 421 ---REHEGAVQL-LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
E EGAV+ +ST+ +++A++ +LEEQ + + + L+
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852
Score = 67.0 bits (162), Expect = 2e-10
Identities = 90/378 (23%), Positives = 170/378 (44%), Gaps = 63/378 (16%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETE-----EKVR-RLKRKNAELAVIAKRLEERARKL 183
L EL Q+ + L EE +L++ ETE E++R RL K EL I +E R +
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 184 QETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ-RETLPLPPSWPPGPALQA 242
++ +++ + ++ +++L L+ Q+ R+ L L +
Sbjct: 942 EDRGQQLQAER-----------KKMAQQMLDLEEQLEEEEAARQKLQLE---------KV 981
Query: 243 RAGAPAPGAPGEATPQEDADNLPVILGEPEK--EQRVQQLESELSKKRKKCESLEQEARK 300
A A E +D +N L + K E+R+ L + L+++ +K ++L + K
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNK---LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATE-KEQV---EWENAELRGQLLGVTQE 356
+ ELE++L++ + L + +L G A++ EQ+ + + AEL+ QL +E
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 357 RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQL--EVEHEQARLSLREKQ-----EEV 409
+AL + L ++ LK +RE+ L +++ E+A + EKQ EE+
Sbjct: 1099 LQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 410 RRLQ----------QAQAEAQREHEGAVQLLESTLD----SMQARVRELEEQCRSQTEQF 455
L+ Q E + + E V +L+ LD S +A+V+E+ ++ E+
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE- 1214
Query: 456 SLLAQELQAFRLHPGPLD 473
L ++L+ F+ LD
Sbjct: 1215 --LTEQLEQFKRAKANLD 1230
Score = 62.8 bits (151), Expect = 3e-09
Identities = 70/325 (21%), Positives = 136/325 (41%), Gaps = 20/325 (6%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
+EE ++ +T+E+ ++ + + EL +L E LQE L+ E + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAEE 915
Query: 201 FDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPG--EATPQ 258
L ++E+ + ++ R + E G LQA A E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEE-------DRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 259 EDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE 318
E+A + L + E ++++LE E+ + L +E + + R +L L + + +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 319 NARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
L + ++ +E E + + R QE + RK +G S EQ+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR-------QELEKLKRKLEGDASDFH--EQIA 1079
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQ 438
++A+ + QL + E+ + +L +E+ + A + RE EG + L+ LDS +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSER 1138
Query: 439 ARVRELEEQCRSQTEQFSLLAQELQ 463
A + E+Q R E+ L EL+
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELE 1163
Score = 60.8 bits (146), Expect = 1e-08
Identities = 90/425 (21%), Positives = 177/425 (41%), Gaps = 62/425 (14%)
Query: 110 LKAKLNMSFGDRPNLELLRALGE-----LRQRCAILKEENQMLRK-------------SS 151
L+ +L R L+L + E L ++ ++N L K ++
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 152 FPETEEKVRRL-KRKN------AELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL 204
E EEK + L K KN +EL V K+ E+ ++L++ ++EG DF
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD----ASDFHEQ 1077
Query: 205 LRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP-QEDADN 263
+ + Q ++ L+ Q+A + + E A + A G + QED D+
Sbjct: 1078 IADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 264 LPVILGEPEKEQRV--QQLES----------------ELSKKRKK-----CESLEQEARK 300
+ EK++R ++LE+ EL KR++ ++L++E R
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ-VEWENAELRGQLLGVTQERDS 359
+ + +E+ + QA E +E+ R + +Q +E ENA+L G+L + Q +
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 360 ALRKSQGLQSKLESLEQVL----KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
K + L+++++ L+ + E+ + +L+ E E L E + + +L +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 416 QAEAQREHEGAVQLLESTLD---SMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPL 472
A + + +LL+ ++ ++R+LEE+ S +Q + Q H L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 473 DLLTS 477
++ S
Sbjct: 1377 NIQLS 1381
Score = 55.8 bits (133), Expect = 4e-07
Identities = 91/431 (21%), Positives = 178/431 (41%), Gaps = 73/431 (16%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRL 162
DEE+EA + ++S + + + L + L+E + +K E E ++
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK----EIENLTQQY 1415
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVEGPQWL------HVRDFDRLLRE----SQREV 212
+ K A + K ++L + + ++ + L R FD+LL E S +
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE---DADNLPVILG 269
R A ++ET L + AL+A+ +A ++ D++ +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 270 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQR---RCE----------ELELQLRQAQ 316
E EK +R LE+++ + + + E LE E + + R E E +LQ R Q
Sbjct: 1536 ELEKSKRA--LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 317 NENAR-------------LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRK 363
NE R L +E + + A K+++E + +L Q + R+ A+++
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
Query: 364 SQGLQSKLESLEQVLKHMR----EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ LQ++++ ++ L+ R E+ ++ E + + L + QE++ ++A+ +A
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 420 QREHEGAVQLLESTLDS----------MQARVRELEEQC--------------RSQTEQF 455
E E + L S+L ++AR+ +LEE+ R T+Q
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 456 SLLAQELQAFR 466
L+ EL R
Sbjct: 1774 EQLSNELATER 1784
Score = 54.3 bits (129), Expect = 1e-06
Identities = 88/393 (22%), Positives = 170/393 (43%), Gaps = 50/393 (12%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS---SFPETEEKV 159
++E++A AKL + N++ L+ G+ + E+N+ R+ E E ++
Sbjct: 1559 EDELQATEDAKLRLEV----NMQALK--GQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 160 RRLKRKNAELAVIAKRLEERARKLQ-ETNLRVEGPQWL--HVRDFDRLLRESQREV--LR 214
+++ A A K+LE + L+ + + ++G + +R +++ QRE+ R
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 215 LQRQIALRNQRETLPLPPSWPPG--PALQARAGAPAPGAPGEATPQEDADNLPVILG--- 269
R +E S + A A + +E A+ L L
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 270 --EPEK---EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ-----NEN 319
+ EK E R+ QLE EL +++ E++ RK ++ E+L +L + NE+
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792
Query: 320 AR--LVEENSRLSGRATEKE------------QVEWENAELRGQLLGVTQERDSALRKSQ 365
AR L +N L + E E +E + A+L Q+ +E+ +A + +
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852
Query: 366 GLQSKL-ESLEQVLKHMREVAQRRQQLEVEH---EQARLSLREKQEEVRRLQQAQAEAQR 421
KL E L QV + Q ++Q E + +Q + L E +EE +R+ + + QR
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1912
Query: 422 EHEGAVQLLES---TLDSMQARVRELEEQCRSQ 451
E + A + E+ ++++++++R Q SQ
Sbjct: 1913 ELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/104 (23%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 362 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
R+ + +Q+K + L++ + ++ ++LE +H Q QE+++ + AEA+
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 422 EH---EGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
Q LE L M+AR+ E E++ + + +AQ++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 68.9 bits (167), Expect = 4e-11
Identities = 91/407 (22%), Positives = 171/407 (42%), Gaps = 48/407 (11%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
L ++ + S + E EA K +S R E L A EL + +LK E +
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLA-RALEEALEAKEELERTNKMLKAEMED 1515
Query: 147 LRKS------SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
L S + E E+ R L+ + E+ + LE+ + ++ LR+E
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 201 FDRLL--RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQ 258
F+R L R+ Q E R Q Q L L AL A A G + Q
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELE---DERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 259 EDADNLPVILGEPEKEQRVQQLES-------ELSKKRKKCESLEQEARKKQRRCEELELQ 311
D+ I G E +++++L++ EL R + + A++ +++ + LE
Sbjct: 1633 ADS----AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 312 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
L Q Q + L+ ++Q + E EL +L R++ + + L++++
Sbjct: 1689 LMQLQED----------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 372 ESLEQVLKH-----------MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
LE+ L+ +R+ Q+ +QL E R + ++ + ++L++ E +
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 421 ---REHEGAVQL-LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
E EGAV+ +ST+ +++A++ +LEEQ + + + L+
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845
Score = 67.0 bits (162), Expect = 2e-10
Identities = 90/378 (23%), Positives = 170/378 (44%), Gaps = 63/378 (16%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETE-----EKVR-RLKRKNAELAVIAKRLEERARKL 183
L EL Q+ + L EE +L++ ETE E++R RL K EL I +E R +
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 184 QETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ-RETLPLPPSWPPGPALQA 242
++ +++ + ++ +++L L+ Q+ R+ L L +
Sbjct: 935 EDRGQQLQAER-----------KKMAQQMLDLEEQLEEEEAARQKLQLE---------KV 974
Query: 243 RAGAPAPGAPGEATPQEDADNLPVILGEPEK--EQRVQQLESELSKKRKKCESLEQEARK 300
A A E +D +N L + K E+R+ L + L+++ +K ++L + K
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNK---LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATE-KEQV---EWENAELRGQLLGVTQE 356
+ ELE++L++ + L + +L G A++ EQ+ + + AEL+ QL +E
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 357 RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQL--EVEHEQARLSLREKQ-----EEV 409
+AL + L ++ LK +RE+ L +++ E+A + EKQ EE+
Sbjct: 1092 LQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 410 RRLQ----------QAQAEAQREHEGAVQLLESTLD----SMQARVRELEEQCRSQTEQF 455
L+ Q E + + E V +L+ LD S +A+V+E+ ++ E+
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE- 1207
Query: 456 SLLAQELQAFRLHPGPLD 473
L ++L+ F+ LD
Sbjct: 1208 --LTEQLEQFKRAKANLD 1223
Score = 62.8 bits (151), Expect = 3e-09
Identities = 70/325 (21%), Positives = 136/325 (41%), Gaps = 20/325 (6%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
+EE ++ +T+E+ ++ + + EL +L E LQE L+ E + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAEE 908
Query: 201 FDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPG--EATPQ 258
L ++E+ + ++ R + E G LQA A E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEE-------DRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 259 EDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE 318
E+A + L + E ++++LE E+ + L +E + + R +L L + + +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 319 NARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
L + ++ +E E + + R QE + RK +G S EQ+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR-------QELEKLKRKLEGDASDFH--EQIA 1072
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQ 438
++A+ + QL + E+ + +L +E+ + A + RE EG + L+ LDS +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSER 1131
Query: 439 ARVRELEEQCRSQTEQFSLLAQELQ 463
A + E+Q R E+ L EL+
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELE 1156
Score = 60.8 bits (146), Expect = 1e-08
Identities = 90/425 (21%), Positives = 177/425 (41%), Gaps = 62/425 (14%)
Query: 110 LKAKLNMSFGDRPNLELLRALGE-----LRQRCAILKEENQMLRK-------------SS 151
L+ +L R L+L + E L ++ ++N L K ++
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 152 FPETEEKVRRL-KRKN------AELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL 204
E EEK + L K KN +EL V K+ E+ ++L++ ++EG DF
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD----ASDFHEQ 1070
Query: 205 LRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP-QEDADN 263
+ + Q ++ L+ Q+A + + E A + A G + QED D+
Sbjct: 1071 IADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 264 LPVILGEPEKEQRV--QQLES----------------ELSKKRKK-----CESLEQEARK 300
+ EK++R ++LE+ EL KR++ ++L++E R
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ-VEWENAELRGQLLGVTQERDS 359
+ + +E+ + QA E +E+ R + +Q +E ENA+L G+L + Q +
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 360 ALRKSQGLQSKLESLEQVL----KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
K + L+++++ L+ + E+ + +L+ E E L E + + +L +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 416 QAEAQREHEGAVQLLESTLD---SMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPL 472
A + + +LL+ ++ ++R+LEE+ S +Q + Q H L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 473 DLLTS 477
++ S
Sbjct: 1370 NIQLS 1374
Score = 55.8 bits (133), Expect = 4e-07
Identities = 91/431 (21%), Positives = 178/431 (41%), Gaps = 73/431 (16%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRL 162
DEE+EA + ++S + + + L + L+E + +K E E ++
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK----EIENLTQQY 1408
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVEGPQWL------HVRDFDRLLRE----SQREV 212
+ K A + K ++L + + ++ + L R FD+LL E S +
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE---DADNLPVILG 269
R A ++ET L + AL+A+ +A ++ D++ +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 270 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQR---RCE----------ELELQLRQAQ 316
E EK +R LE+++ + + + E LE E + + R E E +LQ R Q
Sbjct: 1529 ELEKSKRA--LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 317 NENAR-------------LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRK 363
NE R L +E + + A K+++E + +L Q + R+ A+++
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
Query: 364 SQGLQSKLESLEQVLKHMR----EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ LQ++++ ++ L+ R E+ ++ E + + L + QE++ ++A+ +A
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 420 QREHEGAVQLLESTLDS----------MQARVRELEEQC--------------RSQTEQF 455
E E + L S+L ++AR+ +LEE+ R T+Q
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 456 SLLAQELQAFR 466
L+ EL R
Sbjct: 1767 EQLSNELATER 1777
Score = 54.3 bits (129), Expect = 1e-06
Identities = 88/393 (22%), Positives = 170/393 (43%), Gaps = 50/393 (12%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS---SFPETEEKV 159
++E++A AKL + N++ L+ G+ + E+N+ R+ E E ++
Sbjct: 1552 EDELQATEDAKLRLEV----NMQALK--GQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 160 RRLKRKNAELAVIAKRLEERARKLQ-ETNLRVEGPQWL--HVRDFDRLLRESQREV--LR 214
+++ A A K+LE + L+ + + ++G + +R +++ QRE+ R
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 215 LQRQIALRNQRETLPLPPSWPPG--PALQARAGAPAPGAPGEATPQEDADNLPVILG--- 269
R +E S + A A + +E A+ L L
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 270 --EPEK---EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ-----NEN 319
+ EK E R+ QLE EL +++ E++ RK ++ E+L +L + NE+
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785
Query: 320 AR--LVEENSRLSGRATEKE------------QVEWENAELRGQLLGVTQERDSALRKSQ 365
AR L +N L + E E +E + A+L Q+ +E+ +A + +
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845
Query: 366 GLQSKL-ESLEQVLKHMREVAQRRQQLEVEH---EQARLSLREKQEEVRRLQQAQAEAQR 421
KL E L QV + Q ++Q E + +Q + L E +EE +R+ + + QR
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 422 EHEGAVQLLES---TLDSMQARVRELEEQCRSQ 451
E + A + E+ ++++++++R Q SQ
Sbjct: 1906 ELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/104 (23%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 362 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 421
R+ + +Q+K + L++ + ++ ++LE +H Q QE+++ + AEA+
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 422 EH---EGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
Q LE L M+AR+ E E++ + + +AQ++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 68.6 bits (166), Expect = 5e-11
Identities = 69/338 (20%), Positives = 148/338 (43%), Gaps = 46/338 (13%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIA----KRLEERARKLQETNLRVEGPQWL 196
KEE ++ E EEK+R L+ K E I KR EE + QE E W
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 197 H---VRDFDRLLRESQREVLRLQRQI----ALRNQRETLPLPPSWPPGPALQARAGAPAP 249
+R+ + +RE ++++ R + +I +R + + W + +
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE----- 489
Query: 250 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE 309
E Q++ + E+E+++++ E ++ ++ +K E++ R+++ + E
Sbjct: 490 ----EIWRQKEKMH--------EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE 537
Query: 310 LQLRQAQ---------NENARLVEENSRLSGRATEKEQVEWENAE-LRGQLLGVTQERDS 359
++R+ + +E ++ EE R E+E W E +R Q V ++ +
Sbjct: 538 EKIREQEEMWREEEKMHEQEKIWEEEKR-----QEQEDKMWRQEEKIREQEEKVWRQEEK 592
Query: 360 ALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ + Q + E + + + +RE ++ Q+ E + + +RE++E + ++ E
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 420 QR---EHEGAVQLLESTLDSMQARVRELEEQCRSQTEQ 454
+ E E +Q E T+ + ++RE E++ R Q E+
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Score = 62.8 bits (151), Expect = 3e-09
Identities = 84/394 (21%), Positives = 166/394 (42%), Gaps = 31/394 (7%)
Query: 78 EGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRC 137
E A+ LP QA + E + V A L+A++ + EL L + ++
Sbjct: 252 ERAKLLLPQQQLQAEADHLG---KELQSVSAKLQAQVEEN-------ELWNRLNQQQEEK 301
Query: 138 AILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLH 197
+EE + E EEK+R + K E +R EE + +E R E W
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW-- 359
Query: 198 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP 257
++ + ++E + +++ +R Q E + W + R +
Sbjct: 360 ----EKEEKMRRQEEMMWEKEEKMRRQEEMM-----WEKEEKI--RELEEKMHEQEKIRE 408
Query: 258 QEDADNLPVILGEPEKEQRVQ-QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ 316
QE+ + E EK Q + ++ + K R++ E + ++ +K R+ E++ Q + +
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468
Query: 317 NENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL-E 375
E + EE R + E+E++ + ++ Q + ++ + R+ + ++ + E + E
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 376 QVLKHMREVAQRRQQLEV------EHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQL 429
Q K R+ + R+Q E+ HEQ ++ EK++E Q E RE E V
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 430 LESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 463
E + + + +E EE+ Q E+ +++Q
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622
Score = 52.4 bits (124), Expect = 4e-06
Identities = 66/308 (21%), Positives = 136/308 (44%), Gaps = 35/308 (11%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
+E+ +M R+ +E++ R K K E EE+ RK +E R E +R+
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQ-------EEKIRKQEEKVWRQEEK----IRE 521
Query: 201 FDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQED 260
+ +RE + ++ R + +I R Q E W + + E QE
Sbjct: 522 QEEKIREQEEKMWRQEEKI--REQEEM------WREEEKMHEQEKIWE-----EEKRQEQ 568
Query: 261 ADNLPVILGE-PEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNEN 319
D + + E+E++V + E ++ ++ +K + E++ K++ + E E ++ Q Q E
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKI-QEQEEK 627
Query: 320 ARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLK 379
R EE R E+E++ E E G+ E++ +++ + + E E++ +
Sbjct: 628 IREQEEKIR------EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE--EKIRE 679
Query: 380 HMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQA 439
+++ ++ +++ E E+ EK E Q E +E E ++ E + +
Sbjct: 680 QEKKIREQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 738
Query: 440 RVRELEEQ 447
R+R+ EE+
Sbjct: 739 RLRQQEEK 746
Score = 52.4 bits (124), Expect = 4e-06
Identities = 53/293 (18%), Positives = 129/293 (44%), Gaps = 25/293 (8%)
Query: 134 RQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGP 193
RQ I ++E +K E EEK+R+ + K R EE+ R+ +E E
Sbjct: 480 RQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK-------VWRQEEKIREQEEKIREQEEK 532
Query: 194 QWLH---VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPG 250
W +R+ + + RE ++ + Q +I +R+ W ++ +
Sbjct: 533 MWRQEEKIREQEEMWREEEK--MHEQEKIWEEEKRQEQE-DKMWRQEEKIREQE------ 583
Query: 251 APGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELEL 310
E +++ E+E+++ + E ++ ++ +K + E++ R+++ + E E
Sbjct: 584 ---EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640
Query: 311 QLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSK 370
++ + + E+ + E+E+ W E + +E++ +R+ + + +
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE 700
Query: 371 LESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 423
E E++ + ++ ++ ++++ + E+ R + E+ RL+Q Q E +EH
Sbjct: 701 QE--EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ-QEEKMQEH 750
Score = 48.9 bits (115), Expect = 4e-05
Identities = 44/183 (24%), Positives = 86/183 (46%), Gaps = 28/183 (15%)
Query: 277 VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA--- 333
++Q S ++ ++KK + +E K++ + L L+L + + L E+N++L +
Sbjct: 177 LEQALSAVATQKKKADRYIEELTKER---DALSLELYRNTITDEELKEKNAKLQEKLQLV 233
Query: 334 -TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLE 392
+EK +++ EL+ +L ER L Q LQ++ + L + E
Sbjct: 234 ESEKSEIQLNVKELKRKL-----ERAKLLLPQQQLQAEADHLGK---------------E 273
Query: 393 VEHEQARLSLREKQEEV-RRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ 451
++ A+L + ++ E+ RL Q Q E E +Q E + + ++RE EE+ R Q
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 452 TEQ 454
E+
Sbjct: 334 EEK 336
Score = 48.1 bits (113), Expect = 8e-05
Identities = 41/187 (21%), Positives = 91/187 (48%), Gaps = 19/187 (10%)
Query: 274 EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL------RQAQNENARL---VE 324
++++Q +ESE S+ + + L+++ + + + +LQ ++ Q+ +A+L VE
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 325 ENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREV 384
EN + ++E+ W E + QE++ +R+ + K+ E+ ++ E+
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEM 343
Query: 385 AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVREL 444
+++ E+ + EK+E++RR Q E E E ++ E + + ++REL
Sbjct: 344 MWEKEEKMRRQEE---MMWEKEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 445 EEQCRSQ 451
EE+ Q
Sbjct: 397 EEKMHEQ 403
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/180 (22%), Positives = 90/180 (50%), Gaps = 16/180 (8%)
Query: 278 QQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK- 336
++L+ + +K ++K + +E E + Q +EL+ +L E A+L+ +L A
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL-----ERAKLLLPQQQLQAEADHLG 271
Query: 337 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE 396
++++ +A+L+ Q+ +E + R +Q + K+ E+ ++ E Q +++ E E
Sbjct: 272 KELQSVSAKLQAQV----EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 397 QARLSLREKQEEVRRLQQ---AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 453
+ +RE++E++RR ++ + E R E + E + + + E EE+ R Q E
Sbjct: 328 E---KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 384
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 67.8 bits (164), Expect = 9e-11
Identities = 73/358 (20%), Positives = 164/358 (45%), Gaps = 44/358 (12%)
Query: 131 GELRQRCAILKEENQMLRKSS--FPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
G++R++ ++E+ +R+ E E +VR + + E + E + R+ QE +
Sbjct: 101 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQV 159
Query: 189 RVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPA 248
R + Q VR+ + +RE + +V + Q+ R Q +
Sbjct: 160 REQEGQ---VREQEGQVREQEGQVREQEGQV--REQEGQM-----------------GEQ 197
Query: 249 PGAPGEATPQ-----EDADNLPVILGEPEKEQRVQQ-----LESELSKKRKKCESLEQEA 298
G GE Q E +GE E++ R Q+ E ++ K+ ++ + E++
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 299 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERD 358
RK++ + E E Q+R+ + + + E+ + ++EQ+ + ++R Q + +E++
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQM-REQE 316
Query: 359 SALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQA---RLSLREKQEEVRRLQQ- 414
+R+ + K E EQ+ + ++ ++++Q+ + EQ +++++E+VR+ ++
Sbjct: 317 EQMREQEEQMGKQE--EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374
Query: 415 --AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPG 470
Q E R+ E ++ E + + ++ E +EQ R Q EQ ++++ H G
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 53.1 bits (126), Expect = 2e-06
Identities = 45/194 (23%), Positives = 95/194 (48%), Gaps = 7/194 (3%)
Query: 272 EKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSG 331
E+E +V++ E ++ ++ + E + R+++ + E E Q+R+ + + + G
Sbjct: 56 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 115
Query: 332 RATEKE-QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQ 390
+ E+E QV + ++R Q G +E++ +R+ +G + E QV + +V R Q+
Sbjct: 116 QVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEG--QVREQEGQV--REQE 170
Query: 391 LEVEHEQARLSLREKQEEVRRLQQAQAEAQR-EHEGAVQLLESTLDSMQARVRELEEQCR 449
+V ++ ++ +E Q + Q + E Q E E + E + + ++ E EEQ R
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 450 SQTEQFSLLAQELQ 463
Q EQ +++Q
Sbjct: 231 KQEEQMGEQEEQVQ 244
Score = 51.6 bits (122), Expect = 7e-06
Identities = 46/205 (22%), Positives = 101/205 (49%), Gaps = 17/205 (8%)
Query: 260 DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNEN 319
+ D +P+ +E +V++ E ++ ++ + E + R+++ + E E Q+R+ + +
Sbjct: 42 ETDKIPL-----PQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 96
Query: 320 ARLVEENSRLSGRATEKE-QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVL 378
+ G+ E+E QV + ++R Q G +E++ +R+ +G + E QV
Sbjct: 97 REQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEG--QVR 153
Query: 379 KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQ 438
+ +V ++ Q+ + Q +RE++ +VR Q+ Q RE EG + E + +
Sbjct: 154 EQEGQVREQEGQVREQEGQ----VREQEGQVRE-QEGQV---REQEGQMGEQEGQMGEQE 205
Query: 439 ARVRELEEQCRSQTEQFSLLAQELQ 463
++ E EEQ + Q EQ ++++
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMR 230
Score = 45.8 bits (107), Expect = 4e-04
Identities = 38/125 (30%), Positives = 63/125 (50%), Gaps = 8/125 (6%)
Query: 337 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE 396
E+++ +NAEL+ +L V E+ + L+ KLE+ + L +V ++ Q+ +
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66
Query: 397 QARL---SLREKQEEVRRLQQAQAEAQ----REHEGAVQLLESTLDSMQARVRELEEQCR 449
Q R +RE++ +VR Q+ Q Q RE EG V+ E + + +VRE E Q R
Sbjct: 67 QVREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 450 SQTEQ 454
Q Q
Sbjct: 126 EQEGQ 130
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 1203 EEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPLQ 1262
E+EE+ ++EE++G + QKQ +E + Q + E +E++ EQ ++ Q
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE--QEEQMREQEEQMLKQ 281
Query: 1263 QFCSKKLFSIPEEEEEEEEDEEE 1285
+ +++ E+EE+ E EE+
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQ 304
Score = 32.3 bits (72), Expect = 4.3
Identities = 21/101 (20%), Positives = 52/101 (51%), Gaps = 8/101 (7%)
Query: 1192 GRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETD---- 1247
G+ + + E+EE+ +++EE++G + +KQ +E + Q + + +
Sbjct: 199 GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258
Query: 1248 -SDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEK 1287
+E++ EQ ++ Q+ +++ E+ E+EE+ E+E+
Sbjct: 259 KQEEQMREQEEQMREQE---EQMLKQKEQTEQEEQTGEQEE 296
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 67.8 bits (164), Expect = 9e-11
Identities = 90/359 (25%), Positives = 149/359 (41%), Gaps = 40/359 (11%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLR 148
Q + C R +E E + K + +R R L Q L+++ Q L
Sbjct: 736 QSDERASQRCLRQAEELREQLEREKEALGQQERERARQ-RFQQHLEQEQWALQQQRQRLY 794
Query: 149 KSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRES 208
E E ++ R+ AEL + ++LEE + L LR E + ++ R
Sbjct: 795 SEVAEERERLGQQAARQRAELEELRQQLEESSSALTRA-LRAEFEKGREEQE-----RRH 848
Query: 209 QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDAD-NLPVI 267
Q E+ L++Q+ L Q +W G + A ++ D + ++
Sbjct: 849 QMELNTLKQQLELERQ--------AWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
Query: 268 LGEPE------KEQRVQQLESELSKKRKKCES----LEQEARKKQRRCEELELQLRQAQN 317
+ E KE+ + ES + + R K E+ LEQ RK Q RC EL+ QL +A+
Sbjct: 901 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 960
Query: 318 ENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQV 377
EN RL G +KE+ + + QL +R Q + +L + E+
Sbjct: 961 ENL-------RLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR--QEFEDRLAASEEE 1011
Query: 378 LKHMR-EVA--QRRQQLEVE--HEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 431
+ + E+A Q RQQLE+E H + + +L K+E V L+ A + + +LLE
Sbjct: 1012 TRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1070
Score = 53.9 bits (128), Expect = 1e-06
Identities = 62/217 (28%), Positives = 103/217 (47%), Gaps = 37/217 (17%)
Query: 275 QRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARL----VEENSRLS 330
++ ++L +L ++++ E+E R +QR + LE + Q + RL EE RL
Sbjct: 747 RQAEELREQLEREKEALGQQERE-RARQRFQQHLEQEQWALQQQRQRLYSEVAEERERL- 804
Query: 331 GRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQ 390
G+ +++ E E ELR QL +E SAL ++ + + EQ +H E+ +QQ
Sbjct: 805 GQQAARQRAELE--ELRQQL----EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 858
Query: 391 LEVEH----------EQARLSLREKQ--EEVR------------RLQQAQAEAQREHEGA 426
LE+E E+A L RE++ EE+R RL+ A A+ E E A
Sbjct: 859 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 918
Query: 427 VQ-LLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
+ ++ D +A + ELE+ R E+ S L +L
Sbjct: 919 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQL 955
Score = 47.0 bits (110), Expect = 2e-04
Identities = 94/387 (24%), Positives = 159/387 (41%), Gaps = 81/387 (20%)
Query: 133 LRQRC----AILKEENQMLRK---SSFPETEEKVRRLKR--KNAELAVIAKRLEERARKL 183
L ++C A LK+E+Q + + + E ++++LK E A K + E+ +K+
Sbjct: 641 LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKI 700
Query: 184 QETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR 243
+E +R P+ +L+ ++EV RL+ S LQ+
Sbjct: 701 KEVTVRGLEPE------IQKLIARHKQEVRRLK----------------SLHEAELLQSD 738
Query: 244 AGAPAPGAPGEATPQEDADNLPVILGEPEKE---QRVQQ-LESE---LSKKRKKC----- 291
A +E + LG+ E+E QR QQ LE E L ++R++
Sbjct: 739 ERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVA 798
Query: 292 ---ESLEQEARKKQRRCEELELQLRQ----------AQNENARLVEENSRLSGRATEKEQ 338
E L Q+A +++ EEL QL + A+ E R +E T K+Q
Sbjct: 799 EERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 858
Query: 339 VE-----WENAELRGQ---LLGVTQERDSALRKSQGLQSKL--ESLEQVLKHMREVAQR- 387
+E WE R + LL QE +RK + + +L LE + +E +++
Sbjct: 859 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 918
Query: 388 --------RQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH---EGAVQLLESTLDS 436
R + E E + S R+ QE L+ EA+ E+ +G V+ E L+
Sbjct: 919 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 978
Query: 437 MQARVRELEEQCRSQTEQFSLLAQELQ 463
QA +L + RS Q ++ QE +
Sbjct: 979 AQAVNEQLSSE-RSNLAQ--VIRQEFE 1002
Score = 43.5 bits (101), Expect = 0.002
Identities = 44/184 (23%), Positives = 89/184 (48%), Gaps = 21/184 (11%)
Query: 277 VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 336
+ QL + +KCE++ E +++ +RC E ++ QAQ ++ +++ L ATEK
Sbjct: 631 IDQLIEDKKVLSEKCEAVVAELKQEDQRCTE---RVAQAQAQHELEIKKLKELMS-ATEK 686
Query: 337 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVE-- 394
+ E +E ++ VT +GL+ +++ L + +H +EV + + E E
Sbjct: 687 ARREKWISEKTKKIKEVT---------VRGLEPEIQKL--IARHKQEVRRLKSLHEAELL 735
Query: 395 --HEQARLSLREKQEEVRRLQQAQAEA--QREHEGAVQLLESTLDSMQARVRELEEQCRS 450
E+A + EE+R + + EA Q+E E A Q + L+ Q +++ ++ S
Sbjct: 736 QSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYS 795
Query: 451 QTEQ 454
+ +
Sbjct: 796 EVAE 799
Score = 40.4 bits (93), Expect = 0.016
Identities = 53/222 (23%), Positives = 95/222 (42%), Gaps = 26/222 (11%)
Query: 272 EKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE-------LQLRQAQNENARLVE 324
E E+ QQLE S + + ++ R++Q R ++E L+L + E R +
Sbjct: 814 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 873
Query: 325 ENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG--------------LQSK 370
E + L R E + + + +L+ E D AL K + +++
Sbjct: 874 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 933
Query: 371 LESLEQVLKHMRE-VAQRRQQL-EVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQ 428
L LEQ + ++E ++ + QL E E E RL +Q+E R L+ AQA ++
Sbjct: 934 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKE-RALEDAQAVNEQLSSERSN 992
Query: 429 LLESTLDSMQARVRELEEQCRSQTEQFSLL--AQELQAFRLH 468
L + + R+ EE+ R + + L Q+L+ +H
Sbjct: 993 LAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVH 1034
Score = 33.1 bits (74), Expect = 2.5
Identities = 24/100 (24%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 353 VTQERDSALRK--------SQGLQSKLESLEQVL-KHMREVAQRRQQLEVEHEQARLSLR 403
+ Q+RD R+ S+ LQ + E E + +H+ + Q + +V E+ +
Sbjct: 591 LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVA 650
Query: 404 EKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
E ++E +R + A+AQ +HE ++ L+ + + + RE
Sbjct: 651 ELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE 690
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 67.4 bits (163), Expect = 1e-10
Identities = 100/448 (22%), Positives = 183/448 (40%), Gaps = 79/448 (17%)
Query: 78 EGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRC 137
E +A + QAS++G + + LK K +R + L+ GEL+
Sbjct: 1358 EHLQAAVVEARAQASAAG--ILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 138 AILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLH 197
+EN L + E EE+V L+ + EL E+ R++Q+ L + L
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQEL--------EKQREMQKAALELLS---LD 1464
Query: 198 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATP 257
++ ++ + Q ++ L++ R+ E LP+ A+Q R
Sbjct: 1465 LKKRNQEVDLQQEQIQELEK---CRSVLEHLPM--------AVQEREQKLTVQREQIREL 1513
Query: 258 QEDADNLPVILGEP--EKEQRVQQLESELSKKRK--------KCESLEQEARKKQRRCEE 307
++D + +L E E++ Q +ES+ + + +C +LE E + C++
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ 1573
Query: 308 LELQLRQAQNENAR---------LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERD 358
++ + Q E R L E + L ++++ +E + L +L QERD
Sbjct: 1574 KLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL----QERD 1629
Query: 359 SALRKSQGLQSKLESLEQVLKHMREVAQRRQQ----------------------LEVEHE 396
+ KSQ + ++E L++ +H+ + +RR Q LE + E
Sbjct: 1630 QEV-KSQ--REQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 397 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQF- 455
Q +LSLRE+ E+ +Q E E +G + +L+ M+ +R+ E++ Q E
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 456 ------SLLAQELQAFRLHPGPLDLLTS 477
L Q+LQ G LL S
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Score = 61.6 bits (148), Expect = 7e-09
Identities = 125/512 (24%), Positives = 203/512 (39%), Gaps = 69/512 (13%)
Query: 134 RQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGP 193
+Q+ A KE NQ+ K K ++ +AK LE R+ E +R++
Sbjct: 846 QQKAAHEKEVNQLREKWE-----------KERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 194 QW-LHVRDFDRLLRESQREVLRLQRQIALRNQR----ETLPLPPSWPPGPALQARAGAPA 248
Q + R +Q E Q Q+ +R ETL L A Q
Sbjct: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL-LQTQKELADASQQLERLRQ 953
Query: 249 PGAPGEATPQEDADNLPVILGEPEKE--QRVQQLESELSKKRKKCESLEQEARKKQRRCE 306
+ QE L L E ++E + +Q +L+ +++ SL Q+ Q++ E
Sbjct: 954 DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013
Query: 307 ELELQLRQAQNENARLVEENSRLSGRATEK-----EQVEWENAEL------RGQLLGVTQ 355
+L+ QL AQ+++ RLVE+ + R T++ +++E E A L + Q L V Q
Sbjct: 1014 DLKSQL-VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
Query: 356 ERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 415
E DS Q +L +L Q M+E +++L + E R ++EK+ + +
Sbjct: 1073 EADSIR------QQELSALRQ---DMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 416 QAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL- 474
E Q L ++L + +A+ +L+ + RS Q LA E Q L
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 475 -LTSALDCGSLGDCPPPPCCCSIPQPCRG--SGPKDLDLPPGSPGRCTPKSSEPAPATLT 531
L SAL +LG C S P+ G S P L P G A +
Sbjct: 1184 SLYSALQ-QALGS-----VCESRPELSGGGDSAPSVWGLEPDQNG---------ARSLFK 1228
Query: 532 GVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRG 591
P TA AE+++++ H +H +V++LE L E S+
Sbjct: 1229 RGPLLTALSAEAVASALH--KLHQDLWKTQQTRDVLRDQVQKLEE---RLTDTEAEKSQV 1283
Query: 592 GARIQVFLARYSYN-----PFEGPNENPEAEL 618
+Q + S N +EG + E+EL
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315
Score = 60.8 bits (146), Expect = 1e-08
Identities = 66/336 (19%), Positives = 149/336 (44%), Gaps = 17/336 (5%)
Query: 139 ILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWL-- 196
+L + Q L K + ++E ++ + + E A + R+ E + L ++ + E + +
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 197 HVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEAT 256
+R+ +L + E++ + ++ Q E L L + G G
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHEN 367
Query: 257 PQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQ 316
E ++ + ++ + + S L+++R+ + L Q+ Q L+ Q Q +
Sbjct: 368 SLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWE 427
Query: 317 NENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQ 376
E L + +L+G E++ + + +L+G++ +++ER+ + + L+ +LE LEQ
Sbjct: 428 EEGKALRQRLQKLTG---ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ 484
Query: 377 VLKHMREVAQRRQ--------QLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQ 428
+R V Q Q E + E+ L++RE++ RLQ+ + + ++
Sbjct: 485 EAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE----RLQEMLMGLEAKQSESLS 540
Query: 429 LLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQA 464
L + +++++ E E + QTE + LA+ Q+
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576
Score = 60.1 bits (144), Expect = 2e-08
Identities = 89/375 (23%), Positives = 154/375 (41%), Gaps = 62/375 (16%)
Query: 126 LLRALGELRQRCAILKEENQMLRKSSF-------------PETEEKVRRLKRKNAELAVI 172
L +A ELRQ+ +L++E LR+ + E +E++ R+ L +
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 173 AKRLE-ERARKLQETNLRVEGPQWLHVRDFDRLLRESQREV----LRLQRQIA-LRNQRE 226
LE +++ L E E + H+ LLR+ Q EV R ++ IA L +
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHLE--GELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 227 TLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSK 286
TL RA A A EA + L + Q++ QLE E
Sbjct: 586 TLKT-------EVADLRAAAVKLSALNEA----------LALDKVGLNQQLLQLEEENQS 628
Query: 287 KRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAEL 346
+ E+ EQ L++ L +A+ L E+N+ L + + E+ AEL
Sbjct: 629 VCSRMEAAEQAR-------NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA---GAEL 678
Query: 347 RGQLLGVTQERDSALRK-------SQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 399
+ L + +E++ +K + ++LE L Q K EV R Q + + +
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 400 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQAR-------VRELEEQCRSQT 452
+L + + V R +Q AE + A +LLES+L Q + +LE Q ++ T
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 453 EQFSLLAQELQAFRL 467
+ ++ E++ +L
Sbjct: 799 QAKEVIQGEVRCLKL 813
Score = 58.9 bits (141), Expect = 4e-08
Identities = 75/306 (24%), Positives = 129/306 (42%), Gaps = 45/306 (14%)
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRES-QREV 212
+ E++++ L RK E +++ + E+ LQ+ Q R+ L +S Q ++
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ--------QLQEAREQGELKEQSLQSQL 1805
Query: 213 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 272
QR +A R+Q L+A E +E AD L L +
Sbjct: 1806 DEAQRALAQRDQE--------------LEALQQEQQQAQGQEERVKEKADALQGAL--EQ 1849
Query: 273 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 332
+++ EL +++ LE+E + RR + LE L + E+ +E + L+ +
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE--QEKALLALQ 1907
Query: 333 ATEKEQVEWENAELRG------QLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQ 386
EQ + E R Q V +ERD L L + Q +H E A+
Sbjct: 1908 QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA-------LRAESQSSRHQEEAAR 1960
Query: 387 RRQQ-LEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELE 445
R + L+ +A +L+ K++ + QAE R E + L+++LD+ QA R+LE
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 446 EQCRSQ 451
E R Q
Sbjct: 2017 EALRIQ 2022
Score = 58.2 bits (139), Expect = 7e-08
Identities = 107/452 (23%), Positives = 180/452 (39%), Gaps = 50/452 (11%)
Query: 51 QLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDE-EVEAF 109
Q Q EE K K D + E A L + +R E+E VE
Sbjct: 1826 QQQAQGQEERVKEKADALQGAL-----EQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
Query: 110 LKAKLNMSFGD--RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
L GD + E +AL L+Q+CA +E+++ ++ + LK ++
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ 1940
Query: 168 ELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRET 227
EL + R E ++ + QE R + + + L Q +++ + T
Sbjct: 1941 ELEAL--RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Query: 228 LPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKK 287
L S A + GE Q+ ++ VQQL+ L+++
Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQEGEIQDQD-----------LRYQEDVQQLQQALAQR 2047
Query: 288 RKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELR 347
++E R +Q R + LE L Q EN +++E L G+ E+E++ + +R
Sbjct: 2048 -------DEELRHQQEREQLLEKSLAQRVQEN--MIQEKQNL-GQEREEEEIRGLHQSVR 2097
Query: 348 GQLLGVTQERDSALRKSQGLQ-SKLESL----------EQVLKHMREVAQRRQQLEVEHE 396
L + Q+ L + Q + LE+L EQ LK + + R Q E+E
Sbjct: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK--LDSLEPRLQRELERL 2155
Query: 397 QARLSLREKQE-EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQF 455
QA L E +E E R Q A + + + +V L+ +QA V E + + + ++
Sbjct: 2156 QAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL 2215
Query: 456 SLLAQELQAFRLH-PGPLDLLTSALDCGSLGD 486
L + L+ RLH PG TS + GS G+
Sbjct: 2216 ELTRRALEKERLHSPG----ATSTAELGSRGE 2243
Score = 57.0 bits (136), Expect = 2e-07
Identities = 106/449 (23%), Positives = 184/449 (40%), Gaps = 69/449 (15%)
Query: 50 LQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAF 109
LQL+E S+ + +R D AE +L ++ + Q+ E+ E
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE-- 677
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA-- 167
L+A L ++ E+ + L E R + + + L + + + E R ++ K A
Sbjct: 678 LQADLRDIQEEKE--EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Query: 168 -ELAVIAKRLEERARKLQETNLRVEG----PQWLHVRDFDRLLRESQREVLRLQRQIALR 222
E A + RL+ R Q+ +++G + L F+ + S EV + Q ++ ++
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ 795
Query: 223 NQRET----------LPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 272
+ L L A Q R A A E QE G+
Sbjct: 796 TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE---QE---------GKTA 843
Query: 273 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 332
EQ+ E E+++ R+K E +++ +EL L + E L RL +
Sbjct: 844 LEQQKAAHEKEVNQLREKWE------KERSWHQQELAKALESLEREKMEL---EMRLKEQ 894
Query: 333 ATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQ 389
TE E ++ + E R Q +SAL + Q L+++ E LE +L+ +E+A Q
Sbjct: 895 QTEMEAIQAQREEERTQA-------ESALCQMQ-LETEKERVSLLETLLQTQKELADASQ 946
Query: 390 QLEVEHEQARLSLREKQEEVRRLQQAQAEAQRE---------------HEGAVQLLESTL 434
QLE + ++ ++QE LQ EAQRE E + LL+ +
Sbjct: 947 QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 435 DSMQARVRELEEQCRSQTEQFSLLAQELQ 463
D +Q +V +L+ Q +Q + L+ QE+Q
Sbjct: 1007 D-LQKQVEDLKSQLVAQDDSQRLVEQEVQ 1034
Score = 56.6 bits (135), Expect = 2e-07
Identities = 76/356 (21%), Positives = 149/356 (41%), Gaps = 72/356 (20%)
Query: 154 ETEEKVRRLKRKNAEL-------AVIAKRLEERARKLQETNLRVEG--------PQWLHV 198
+ EE+ + L+ +++++ V+A+ L+ER ++++ ++E Q L
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 199 RDFDRLLRESQREVLRLQR--------------QIALRNQRETLPLPPSWPPGPALQARA 244
RD + +L++ + +VL QR +++LR + L +Q RA
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQ-----LMQERA 1710
Query: 245 GAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRR 304
G + +++ +IL + EKE QQ + + ++ + LEQ+ + R+
Sbjct: 1711 ---EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ--EHIHELQELKDQLEQQLQGLHRK 1765
Query: 305 CEELELQLRQAQNE----------------------NARLVEENSRLSGRATEKEQVEWE 342
E L L Q + E ++L E L+ R E E ++ E
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 343 NAELRGQ----------LLGVTQERDSALRKSQG-LQSKLESLEQVLKHMREVAQRRQQL 391
+ +GQ L G ++ L++ G LQ E ++ + + +R Q L
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 392 EVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQ 447
E R RE+++ + LQQ AE +EHE + L+ + QA ++E +++
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
Score = 54.7 bits (130), Expect = 8e-07
Identities = 91/412 (22%), Positives = 177/412 (42%), Gaps = 46/412 (11%)
Query: 51 QLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQ-QASSSGPACQRPEDEEVEAF 109
+L+ LR+E S + ++R AEA +LG+ A+ G E E+
Sbjct: 1941 ELEALRAESQSSRHQEEAARA-------RAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 110 LKA-----KLNMSFGDRPNLELLRAL----GELRQRCAILKEENQMLRKSSFPETEEKVR 160
L+A + ++ + +L AL GE++ + +E+ Q L+++ EE
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVEGPQ----WLH--VRDFDRLLRESQREVLR 214
+ +R+ +A+R++E + ++ NL E + LH VR+ L + ++E+L
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQ-EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Query: 215 LQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKE 274
L R+ RN E LP P + + P Q + + L L + E
Sbjct: 2113 L-RETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL------QRELERLQAALRQTEAR 2165
Query: 275 Q-----RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE---NARLVEEN 326
+ + Q L L++ + SL++ A Q E + + ++ Q+E R +E+
Sbjct: 2166 EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Query: 327 SRLSGRATEKEQV--EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREV 384
S AT ++ E G++ GV E + Q + +LE L+Q + +
Sbjct: 2226 RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE-- 2283
Query: 385 AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDS 436
R +L+ + Q R +L + + E R+L++ A + G++++ ++T S
Sbjct: 2284 -IDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ--AGSLEISKATASS 2332
Score = 54.3 bits (129), Expect = 1e-06
Identities = 84/359 (23%), Positives = 154/359 (42%), Gaps = 65/359 (18%)
Query: 138 AILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLH 197
A+ EEN + +E + + + L + LEER+++LQ + ++ + H
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE-SH 1617
Query: 198 VRDFDRLLRESQREVLRLQRQIA-LRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEAT 256
R L+E +EV + QI L+ Q+E L T
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHL---------------------------T 1650
Query: 257 PQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCES-LEQEARKKQRRCEELELQLRQA 315
+ + ++L +++R+Q LE + +++ K E LEQ + R EL Q RQ
Sbjct: 1651 QDLERRDQELML----QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ-RQL 1705
Query: 316 QNENA----------RLVEENSRLSGRATEKE-QVEWENAELRGQLLGVTQERDSALRKS 364
E A R E+ +L R EKE + + E+ +L +++ L +
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
Query: 365 QGLQSKLES--------LEQVLKHMREVAQRRQQ-LEVEHEQARLSLREKQEEVRRLQQA 415
G S L S L+Q L+ RE + ++Q L+ + ++A+ +L ++ +E+ LQQ
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 416 QAEAQREHE----------GAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQA 464
Q +AQ + E GA++ TL +++ +EQ R E+ ++ + +QA
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884
Score = 48.1 bits (113), Expect = 8e-05
Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 24/210 (11%)
Query: 274 EQRVQQLESELSKKRKKCESLEQEARKK-------QRRCEELELQLRQAQNENARLVEEN 326
++++ Q + E SK K SLE E + Q R ELQ +AQ E L
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQE-----RDSALRKSQGLQSKLESLEQVLKHM 381
L+ + E Q A + G+ +E R + K++ ++S+ E + + +
Sbjct: 1351 ENLTAQ-VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409
Query: 382 REVAQRRQQLEVEHEQARLSLREKQEEVRRL--QQAQAEAQRE-HEGAVQLLESTL---- 434
+ + L+ +L E++EEV L Q + E QRE + A++LL L
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN 1469
Query: 435 ---DSMQARVRELEEQCRSQTEQFSLLAQE 461
D Q +++EL E+CRS E + QE
Sbjct: 1470 QEVDLQQEQIQEL-EKCRSVLEHLPMAVQE 1498
Score = 47.0 bits (110), Expect = 2e-04
Identities = 86/356 (24%), Positives = 148/356 (41%), Gaps = 39/356 (10%)
Query: 120 DRPNL-ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVI--AKRL 176
+ PNL ELL L E +QRC L E N LR E + V + R++ E + ++
Sbjct: 92 EEPNLDELLVRLEEEQQRCESLAEVNTQLRLHM--EKADVVNKALREDVEKLTVDWSRAR 149
Query: 177 EERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQR---QIALRNQRETLPLPPS 233
+E RK + + E + + RLL REV+ +R ++ R+ + L
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLL-SLWREVVTFRRHFLEMKSATDRDLMELKAE 208
Query: 234 WPP------GPALQARAGAPA--PGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELS 285
L+ GA + P G +E A L ++ E E+ + EL
Sbjct: 209 HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268
Query: 286 KKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAE 345
+ + + + E + Q R EL L Q+Q +N + + E +E + E
Sbjct: 269 QLKSQG---DLEKAELQDRVTELSALLTQSQKQNE---DYEKMIKALRETVEILETNHTE 322
Query: 346 LRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK 405
L E +++L S+ Q + SL+QV+K + +V +E A+ S E
Sbjct: 323 L--------MEHEASL--SRNAQEEKLSLQQVIKDITQV-----MVEEGDNIAQGSGHEN 367
Query: 406 QEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQE 461
E+ +Q + Q + + A+ L+ S L + V++L +Q E +LL Q+
Sbjct: 368 SLELDSSIFSQFDYQ-DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Score = 47.0 bits (110), Expect = 2e-04
Identities = 48/207 (23%), Positives = 93/207 (44%), Gaps = 27/207 (13%)
Query: 274 EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA 333
E+R+ E+E S+ + + L+++ + Q + E + ++E L E + L R
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL 1329
Query: 334 TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEV 393
+ E + E +G ER+ + L +++E L+ + R A LE
Sbjct: 1330 ---RRAELQRMEAQG-------ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379
Query: 394 EHEQARLSLREKQEEVR-------------RLQQAQAEAQREHEGAV-QLL---ESTLDS 436
+ AR +L+ K EEV L+ AQ +A +E+ + Q L E +++
Sbjct: 1380 DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET 1439
Query: 437 MQARVRELEEQCRSQTEQFSLLAQELQ 463
++ +++ELE+Q Q LL+ +L+
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLK 1466
Score = 31.6 bits (70), Expect = 7.3
Identities = 49/212 (23%), Positives = 84/212 (39%), Gaps = 47/212 (22%)
Query: 270 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 329
E +E + +L L +++++CESL + +L L + +A N L E+
Sbjct: 89 ENVEEPNLDELLVRLEEEQQRCESLAEVN-------TQLRLHMEKADVVNKALRED---- 137
Query: 330 SGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKH--------M 381
EK V+W A RD +RK Q + E + LK
Sbjct: 138 ----VEKLTVDWSRA------------RDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181
Query: 382 REVAQ-RRQQLEVEHEQARLSLREKQEEVRR--------LQQAQAEAQREHEGAVQL--- 429
REV RR LE++ R + K E VR L+ RE G+ ++
Sbjct: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
Query: 430 LESTLDSMQARVRELEEQCRSQTEQFSLLAQE 461
+ L + A+ +ELE++ ++++ L +
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQ 273
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 67.4 bits (163), Expect = 1e-10
Identities = 112/410 (27%), Positives = 175/410 (42%), Gaps = 72/410 (17%)
Query: 104 EEVEAFLKAKLNMSFG-DRPNLELLR-ALGELRQRCAILKEENQMLRKSSFPETEEKVRR 161
+E EA L AK + +R L+ L AL LRQ+ + + ++ L+++ E+ +
Sbjct: 836 KEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEV-EVTHETLQRNRPDSGVEEAWK 894
Query: 162 LKRKNAELAVIAKRLEERARKLQET--NLRVEGPQWLHVRDF------DRLLRESQREVL 213
++++ E ++LE + QE LR +GPQ VR D +L ES +++
Sbjct: 895 IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQ 954
Query: 214 RLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEK 273
R + +NQ L LQ RA G+ ++ V+ EP++
Sbjct: 955 RTLAEEQHKNQLLQEELEAL-----QLQLRALEQETRDGGQEYVVKE-----VLRIEPDR 1004
Query: 274 EQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSG 331
Q V QL EL EA ++Q+ E E+ L Q A L EE SR
Sbjct: 1005 AQADEVLQLREEL------------EALRRQKGAREAEVLL--LQQRVAALAEEKSRAQE 1050
Query: 332 RATEKEQVEWEN---AELRGQLLGVTQERDSALRKSQG-----LQSKLESLE-------- 375
+ TEKE V+ +N E Q L +R LR+ Q LQ KL+ LE
Sbjct: 1051 KVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEG 1110
Query: 376 -----QVLKHMREVAQRRQ------QLEVEHEQARLSLREKQEEVRRL-----QQAQAEA 419
+VLK ++ A R+ Q E E +AR S REK E +R++ + A+
Sbjct: 1111 KITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVV 1170
Query: 420 QREHEGAVQ---LLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
Q + V+ ES + +++ + E E + R EQ EL+A R
Sbjct: 1171 QEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALR 1220
Score = 63.2 bits (152), Expect = 2e-09
Identities = 93/369 (25%), Positives = 158/369 (42%), Gaps = 56/369 (15%)
Query: 121 RPNLELLR---ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE 177
R ELLR AL E + + ++ +++R P+ E +V L+ + E + E
Sbjct: 1149 REKTELLRKIWALEEENAKVVVQEKVREIVRPD--PKAESEVANLRLELVEQERKYRGAE 1206
Query: 178 ERARKLQET--NLRVEGPQWLHVRDFDRLL------RESQREVLRLQRQIALRNQRETLP 229
E+ R Q LR GPQ + V++ + + E ++E+ RL+ +I + +
Sbjct: 1207 EQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERC 1265
Query: 230 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 289
+ +QA + +E + +P+ ++ V L ++LS+++K
Sbjct: 1266 DLEIYQLKKEIQALKDTKP-----QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK 1320
Query: 290 KCESLEQEARKKQRRCEELELQLRQAQNEN-ARLVEENSRLSGRATEKEQVEWENAE-LR 347
K LE+E R +Q E AR EE SR+ R ++E V +E LR
Sbjct: 1321 KQVDLERE---------------RASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLR 1365
Query: 348 GQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLE---VEHEQARLSLRE 404
+ + D LR+ L+++L L++ RR +LE E E+ R + RE
Sbjct: 1366 AEASAFAESIDVELRQIDKLRAELRRLQR----------RRTELERQLEELERERQARRE 1415
Query: 405 KQEEVRRLQQAQAEAQREHEGAVQLLEST------LDSMQARVRE-LEEQCRSQTEQFSL 457
+ EV+RLQQ A ++E A + + T D QAR L Q + + L
Sbjct: 1416 AEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQL 1475
Query: 458 LAQELQAFR 466
L EL+ R
Sbjct: 1476 LEGELETLR 1484
Score = 57.8 bits (138), Expect = 9e-08
Identities = 80/355 (22%), Positives = 158/355 (44%), Gaps = 50/355 (14%)
Query: 127 LRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE-ERARKLQE 185
++AL + + + + ++L+ P+T+E+V L+ K +E K+++ ER R QE
Sbjct: 1276 IQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ--KKQVDLERERASQE 1333
Query: 186 TNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAG 245
+ + + V++ R Q+EV+R + + P L+A A
Sbjct: 1334 EQIARKEEELSRVKE-----RVVQQEVVRYEEE-------------------PGLRAEAS 1369
Query: 246 APAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRC 305
A A E D L L +R+Q+ +EL ++ ++ E Q R+ +R
Sbjct: 1370 AFAESIDVEL---RQIDKLRAEL------RRLQRRRTELERQLEELERERQARREAEREV 1420
Query: 306 EELELQLRQAQNENARLVEENSRLSGRATEKE-QVEWENAELRGQLLGVTQERDSALRKS 364
+ L+ +L + E A E+ + +++ Q E+A LR QL + +
Sbjct: 1421 QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL-------EEEQHRR 1473
Query: 365 QGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHE 424
Q L+ +LE+L + L + E A+ ++++ V E ++ + ++E++RL+ + E R
Sbjct: 1474 QLLEGELETLRRKLAAL-EKAEVKEKV-VLSESVQVEKGDTEQEIQRLKSSLEEESRSKR 1531
Query: 425 GAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSAL 479
L+ + ++AR+ ELE +++ L +E +L L L T L
Sbjct: 1532 E----LDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRL 1582
Score = 57.4 bits (137), Expect = 1e-07
Identities = 88/364 (24%), Positives = 155/364 (42%), Gaps = 72/364 (19%)
Query: 101 PEDEEVEAFLKAKLNMSFGDRPNLELLRA------------LGELRQRCA----ILKEEN 144
P+ +E A L+AKL+ + +LE RA L +++R + EE
Sbjct: 1302 PQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEE 1361
Query: 145 QMLRK--SSFPET-EEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDF 201
LR S+F E+ + ++R++ + AEL + +R E R+L+E +
Sbjct: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQAR-------- 1413
Query: 202 DRLLRESQREVLRLQRQIALRNQRET-------------LPLPPSWPPGPAL-------- 240
RE++REV RLQ+++A Q E L P AL
Sbjct: 1414 ----REAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEE 1469
Query: 241 ----QARAGAPAPGAPGEATPQEDADNLPVILGEP------EKEQRVQQLESELSKKRKK 290
Q G A ++ V+L E + EQ +Q+L+S L ++ +
Sbjct: 1470 QHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRS 1529
Query: 291 CESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQL 350
L+ E + + R ELE ++ E L EEN +L E++ ++ E L+ ++
Sbjct: 1530 KRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQ---LERQNLQLETRRLQSEI 1586
Query: 351 -LGVTQERD----SALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARL-SLRE 404
+ T+ RD + S+L SLE+ L ++ ++ + + LE++ Q RL S+
Sbjct: 1587 NMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLS-KDKDLEIDELQKRLGSVAV 1645
Query: 405 KQEE 408
K+E+
Sbjct: 1646 KREQ 1649
Score = 50.1 bits (118), Expect = 2e-05
Identities = 73/338 (21%), Positives = 145/338 (42%), Gaps = 38/338 (11%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
AL E + R E ++++ + P+ E + ++L+ + + ++ EE LQ+
Sbjct: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLK 1099
Query: 189 RVEGPQWLHVRDFDRLLRESQ---REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAG 245
R+E +R + E + +EVL++++ A +RE L + A +ARA
Sbjct: 1100 RLEK---------ERAMAEGKITVKEVLKVEKDAA--TEREVSDLTRQYED-EAAKARAS 1147
Query: 246 APAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRC 305
+ +N V++ E +E ++E + E +EQE +K R
Sbjct: 1148 QREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE--RKYRGA 1205
Query: 306 EELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE-NAELRGQLLGVTQERDSALRKS 364
EE QLR Q+E L ++ + KE ++++ + E+ +L + +E R
Sbjct: 1206 EE---QLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLI 1262
Query: 365 QGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHE 424
+ ++ L++ ++ +++ + Q EV V+ + Q Q + Q + E
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEV---------------VQEILQFQEDPQTKEE 1307
Query: 425 GAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 462
V L + L Q + +LE + SQ EQ + +EL
Sbjct: 1308 --VASLRAKLSEEQKKQVDLERERASQEEQIARKEEEL 1343
Score = 44.7 bits (104), Expect = 8e-04
Identities = 89/411 (21%), Positives = 162/411 (39%), Gaps = 100/411 (24%)
Query: 143 ENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFD 202
EN + + + PE+ R L K ELA +A L+ + L E ++ +
Sbjct: 632 ENHLNQDDTVPESS---RVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLAS 688
Query: 203 RL------LRESQREVLRL-QRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEA 255
R L + EV +L QR LR Q E +LQ+ A G
Sbjct: 689 RFQEHCPDLERQEAEVHKLGQRFNNLRQQVERR--------AQSLQSAKAAYEHFHRGHD 740
Query: 256 TPQEDADNLPVILGEPEKEQRVQQLESELSKKRK---KCESLEQEARK-------KQRRC 305
+ ++P EP++ + Q+E++L ++ + S EQE +K Q+
Sbjct: 741 HVLQFLVSIPSY--EPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAV 798
Query: 306 EELELQ------LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDS 359
++ EL+ L +N + V + +RL AT+ ++ E A ++ + ++R
Sbjct: 799 KDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQ 858
Query: 360 ALRKSQGL-------------------QSKLESLEQVLKHMREVAQRRQQLEVEHEQAR- 399
L + L S +E ++ K + E +RR+QLE E + +
Sbjct: 859 NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQE 918
Query: 400 --LSLREK--------------------QEEVRRLQQAQAEAQREHEGAVQLLESTLDSM 437
+LR + +E ++LQ+ AE Q ++ QLL+ L+++
Sbjct: 919 EIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN----QLLQEELEAL 974
Query: 438 QARVRELEEQC------------------RSQTEQFSLLAQELQAFRLHPG 470
Q ++R LE++ R+Q ++ L +EL+A R G
Sbjct: 975 QLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKG 1025
Score = 37.4 bits (85), Expect = 0.13
Identities = 62/255 (24%), Positives = 103/255 (40%), Gaps = 47/255 (18%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKE----ENQMLRKSSFPE 154
Q P+ A L+ +L R LE L LR++ A L++ E +L +S E
Sbjct: 1451 QDPQQAREHALLRLQLEEEQHRRQLLE--GELETLRRKLAALEKAEVKEKVVLSESVQVE 1508
Query: 155 ---TEEKVRRLK-------RKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL 204
TE++++RLK R EL V RLE R +L+ N + ++ D L
Sbjct: 1509 KGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSS-------KELDFL 1561
Query: 205 LRESQREVLRLQRQ-IALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADN 263
E+ + L+L+RQ + L +R LQ+ A T D N
Sbjct: 1562 REENHK--LQLERQNLQLETRR--------------LQSEINMAA-------TETRDLRN 1598
Query: 264 LPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLV 323
+ V + R+ LE EL ++ + + E + Q+R + ++ Q +N R +
Sbjct: 1599 MTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSI 1658
Query: 324 EENSRLSGRATEKEQ 338
+GR E+
Sbjct: 1659 VVIHPDTGRELSPEE 1673
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 67.0 bits (162), Expect = 2e-10
Identities = 44/182 (24%), Positives = 98/182 (53%), Gaps = 8/182 (4%)
Query: 279 QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE--K 336
QLE +L +K ++ E +E+E K+++ E+L L+ +A+NEN++L EN RL + + +
Sbjct: 119 QLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ 178
Query: 337 EQVEWE-NAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEH 395
+ ++++ + + + L + DS R L K L Q L ++ + + +++EV++
Sbjct: 179 DIIDYQKQIDSQKETLLSRRGEDSDYRSQ--LSKKNYELIQYLDEIQTLTEANEKIEVQN 236
Query: 396 EQARLSLREKQEEVRRLQQAQAEAQ---REHEGAVQLLESTLDSMQARVRELEEQCRSQT 452
++ R +L E +E+ ++ + + + + L+ D Q +V+EL + +S+
Sbjct: 237 QEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
Query: 453 EQ 454
E+
Sbjct: 297 EE 298
Score = 53.5 bits (127), Expect = 2e-06
Identities = 87/402 (21%), Positives = 169/402 (42%), Gaps = 84/402 (20%)
Query: 78 EGAEACLPSLGQQASSSGPACQ--RPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
E A LP L Q C+ + E EV+ L + EL + +G +++
Sbjct: 2080 EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKK 2139
Query: 136 RCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA--RKLQETNLRVEGP 193
++ EN+ L+K+S T EK+ ++++N +L ++L+ + + +G
Sbjct: 2140 VVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGT 2199
Query: 194 QWLHVRDFDRLLRESQREV-----LRL-QRQIALRNQRETLPLPPSWPPGPALQARAGAP 247
+ + + + +RL +E ++E LR+ + + + N++ T+ L + G LQ A +
Sbjct: 2200 EKI-IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET---GKRLQF-AESR 2254
Query: 248 APGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEE 307
P G D+ + I+ E ++++LE++++KK + L+Q
Sbjct: 2255 GPQLEG-----ADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQ----------- 2298
Query: 308 LELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGL 367
LV+E ATE+EQ K
Sbjct: 2299 --------------LVKE-------ATEREQ------------------------KVNKY 2313
Query: 368 QSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAV 427
LE ++LKH+ E A+ Q L+ E + RL+ + +E L Q EA ++ GA
Sbjct: 2314 NEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIH-QIEANKDQSGA- 2371
Query: 428 QLLESTL---DSMQARVRELEEQCRSQTEQFSLLAQELQAFR 466
EST+ D ++ ++++LE Q + + L +E++ +
Sbjct: 2372 ---ESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/211 (21%), Positives = 91/211 (43%), Gaps = 36/211 (17%)
Query: 260 DADNLPVILGEPEKEQRVQQLESELSK-------KRKKCESLEQEARKKQRRCEELELQL 312
DAD ++ E E+ +L+ E+SK R++ E L + + + + E L +QL
Sbjct: 1132 DADRQRIL----ELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL 1187
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLE 372
Q ++ +E S ++ ++ A G+L +T + + L+ KL+
Sbjct: 1188 LDYQAQS----DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLD 1243
Query: 373 SLEQVL-----------KHMREVAQR-RQQLE-----VEHEQARLSLREKQEEVRRLQQA 415
EQ L KH+R+ Q R+Q + E+ ++ + Q + ++ Q
Sbjct: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
Query: 416 QAEAQREHEGAVQLLESTLDSMQARVRELEE 446
+Q+EH +E+ M+ +++ LEE
Sbjct: 1304 MKNSQQEHRN----MENKTLEMELKLKGLEE 1330
Score = 43.5 bits (101), Expect = 0.002
Identities = 86/422 (20%), Positives = 161/422 (38%), Gaps = 116/422 (27%)
Query: 128 RALGELRQRCAILKEENQMLRKSSFPETEEKVRR-LKRKNAELAVIAKRLEERARKLQET 186
+ + ELR R E +++ + E E K LK + +A + RL ++ L++
Sbjct: 1500 KVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKK- 1558
Query: 187 NLRVEGPQWLHVRDFDRLL---RESQREV--------------LRLQRQIALRNQRETLP 229
+ RLL RE QRE+ L LQ +L ++T
Sbjct: 1559 --------------YQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT-- 1602
Query: 230 LPPSWPPGPALQARAGAPAPG-------APGEATPQEDADNLPVILGEPEKEQRVQQLES 282
+W L ++ P P A E T E D+L +L + +K + + +
Sbjct: 1603 ---AWD----LMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQR 1655
Query: 283 ELSKKRKK---------CESLEQEARKKQRRCEELELQLRQAQNENARLVEE-------N 326
E+++ + K E+ E E +K + E+L+ L Q+Q E+ L E N
Sbjct: 1656 EITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN 1715
Query: 327 SRLSGRA--------------TEKEQVEWENA--ELRGQLLGVTQERDSAL--------- 361
SR EK+Q A ELR ++ +ER +
Sbjct: 1716 SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLN 1775
Query: 362 ------RKSQGLQSKLESLEQVLKHMREVAQ----RRQQLEVEHEQARLSLREKQEEVRR 411
R ++ L++++E L + L ++E + R L L++KQ+ +
Sbjct: 1776 VQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNK 1835
Query: 412 LQQAQAEAQREHEGAVQLL----------------ESTLDSMQARVRELEEQCRSQTEQF 455
+ + + E +E++ + + +S ++ +Q +V++LE Q + E+
Sbjct: 1836 ILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV 1895
Query: 456 SL 457
L
Sbjct: 1896 DL 1897
Score = 40.4 bits (93), Expect = 0.016
Identities = 61/313 (19%), Positives = 142/313 (45%), Gaps = 33/313 (10%)
Query: 149 KSSFPETEEKVRRLKRK--------NAELAVIAKRLEERARKLQETNLRVEGPQWLHVRD 200
K F + +++ L+RK + L + A E+ +L++ NL +E L++R
Sbjct: 1947 KDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEN-DILYMRA 2005
Query: 201 FDRLLRESQREVLRLQRQI------ALRNQ--RETLPLPPSWPPGPALQARAGAPAPGAP 252
L R+S E L LQ + AL Q ++T S P +++
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTY----SKPSISGIESDDHCQREQEL 2061
Query: 253 GEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL 312
+ + ++N+ + + + + +L++++ ++ CE L++E + QR+ +
Sbjct: 2062 QKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV---- 2117
Query: 313 RQAQNENARLVEENSRLSGRATE-KEQVEWENAELRGQLLGVTQERDSAL-RKSQGLQSK 370
+ + + + E + G + E+V+ EN +L+ +T E+ + + ++++ L+++
Sbjct: 2118 -RGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAE 2176
Query: 371 LESLE-----QVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEG 425
LE L+ Q+ H + +++ E+E+ R L+++ + +L+ A+ + +E
Sbjct: 2177 LEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEK 2236
Query: 426 AVQLLESTLDSMQ 438
LE T +Q
Sbjct: 2237 MTVQLEETGKRLQ 2249
Score = 38.1 bits (87), Expect = 0.078
Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 30/185 (16%)
Query: 284 LSKKRKKCESLEQEARKKQRRC----EELELQLRQAQNENARLVEENSRLSGRATEKEQV 339
+SKK E E R++ C E L L+Q + N L + + L+ + ++V
Sbjct: 1055 ISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKV 1114
Query: 340 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLK----HMREVAQ-RRQQLEVE 394
E LR +L + S + + L+ LE E LK +RE++ R+Q+E+
Sbjct: 1115 E---QMLRDELADSVSKAVSDADRQRILE--LEKNEMELKVEVSKLREISDIARRQVEIL 1169
Query: 395 HEQARLSLREKQEEVRRLQQAQAEAQ----------REHEGAVQLLEST----LDSMQAR 440
+ Q + R+K+ E R+Q +AQ +H ++QL E+T L+S+ ++
Sbjct: 1170 NAQQQS--RDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSK 1227
Query: 441 VRELE 445
++++E
Sbjct: 1228 LQKME 1232
Score = 35.4 bits (80), Expect = 0.50
Identities = 43/201 (21%), Positives = 90/201 (44%), Gaps = 9/201 (4%)
Query: 252 PGEATPQED-ADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELEL 310
P + QE+ ADNL + L + E V +L+SE + + Q K + +E+EL
Sbjct: 15 PDDLPRQEELADNLLISLSKVE----VNELKSEKQENVIHLFRITQSLMKM--KAQEVEL 68
Query: 311 QLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSK 370
L + + + ++L + + E E E A+ R+ + + L+ K
Sbjct: 69 ALEEVEKAGEEQAKFENQLKTKVMKLEN-ELEMAQQSAGGRDTRFLRNEICQLEKQLEQK 127
Query: 371 LESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLL 430
LE + K + + + +QL + +E+A + + E +RL++ + ++ + +
Sbjct: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187
Query: 431 ESTLDSMQARVRELEEQCRSQ 451
+S +++ +R R + RSQ
Sbjct: 188 DSQKETLLSR-RGEDSDYRSQ 207
Score = 35.4 bits (80), Expect = 0.50
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 4/153 (2%)
Query: 269 GEPEKEQRVQQLE-SELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENS 327
G+ E+++ L +S+ + K E L +E +K+R E + + QN+ LVEEN
Sbjct: 586 GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK 645
Query: 328 RLSGRATEKEQVEWENAELRGQLLGVTQERDSAL-RKSQGLQSKLESLEQVLKHMREVAQ 386
+L E Q E + G T +L R ++SK + E + +
Sbjct: 646 QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESK--NAEGIFDASLHLKA 703
Query: 387 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEA 419
+ QL +E+ R LRE ++E Q A+A
Sbjct: 704 QVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736
Score = 33.9 bits (76), Expect = 1.5
Identities = 77/360 (21%), Positives = 147/360 (40%), Gaps = 48/360 (13%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
E+L+A+ E+++ + E ++ P E V ++ KNAE + L +A+ Q
Sbjct: 653 EILQAIKEMQKDPDVKGGETSLI----IPSLERLVNAIESKNAE-GIFDASLHLKAQVDQ 707
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRN------QRETLPLPPSWPPGP 238
T E Q L RES++E + +Q+A N ++ET L S
Sbjct: 708 LTGRNEELRQEL---------RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNV 758
Query: 239 ALQARAGAPAPGAPGEAT-PQEDADNLPVILGEPE-KEQRVQQLESELSKKRKKCESLEQ 296
+ P AP A+ + L +L E E KE++++ LE L +K +
Sbjct: 759 VFKG-IDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVI-- 815
Query: 297 EARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQE 356
R +Q + L ++ ++ ++E R + ++ Q + + LL Q
Sbjct: 816 --RHQQSLLYKEYLSEKETWKTESKTIKEEKR---KLEDQVQQDAIKVKEYNNLLNALQM 870
Query: 357 RDSALRKSQGLQSKLESLEQV-----LKHMREVAQRRQQLEVEHEQARLSLREKQEEV-- 409
++K S+ ++ QV ++ + + +QL E+E+ + L + EV
Sbjct: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
Query: 410 -----RRLQQAQ----AEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQ 460
+R ++ A Q+ + +V L E L + Q EL + R ++ ++L Q
Sbjct: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQ--YNELTAKYRDILQKDNMLVQ 988
Score = 33.9 bits (76), Expect = 1.5
Identities = 50/242 (20%), Positives = 98/242 (40%), Gaps = 49/242 (20%)
Query: 268 LGEPEKEQRVQ-QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVE-- 324
L + EK + QL+++ K ++ ++ +QE R + + E+EL+L+ + + L +
Sbjct: 1280 LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTK 1339
Query: 325 ------------ENSRLSGRATEKEQV-EWENAELRGQLLGVTQERDSALRKSQGLQSKL 371
E RL +E V + E + ++ + S+L + Q+K
Sbjct: 1340 GAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKF 1399
Query: 372 ESLEQVLKHMREVAQR-------RQQLEVEH--------------------EQARLSLRE 404
Q+ REV RQQ E+ + Q ++LR+
Sbjct: 1400 HEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459
Query: 405 KQEEVRRLQQAQA------EAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 458
+E +R + + +A E +E E A++L E + S + EL + + E+ L+
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI 1519
Query: 459 AQ 460
A+
Sbjct: 1520 AE 1521
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 67.0 bits (162), Expect = 2e-10
Identities = 83/364 (22%), Positives = 154/364 (42%), Gaps = 44/364 (12%)
Query: 133 LRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE---ERARKLQETNLR 189
LRQ + + L + E + V+ R AE ++ ++ E E+AR+LQE +
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 190 VEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAP 249
+ + F R L E++R QRQ+ + + E L L A +RA A A
Sbjct: 2353 MAQQLAEETQGFQRTL-EAER-----QRQLEMSAEAERLKLRV------AEMSRAQARA- 2399
Query: 250 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE 309
+EDA E +++ + E +K ++LE + ++ E L
Sbjct: 2400 --------EEDAQRFRK--QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 310 LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGL 367
+ + + E +L +E L ++ E + V+ E Q L E+DS L++ + +
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 368 QSKLESLEQVL---------------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
+ + LEQ+ + +++ Q RQ+L E+AR E +E VRR
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGP 471
Q+ + +++ +LL ++ +++ LEEQ R+ + A ++ A + P
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 472 LDLL 475
D L
Sbjct: 2630 RDAL 2633
Score = 65.1 bits (157), Expect = 6e-10
Identities = 104/428 (24%), Positives = 175/428 (40%), Gaps = 58/428 (13%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
LG+ S++ + E E+EA + +L R R E Q+ +EE
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEERVQKSLAAEEEAAR 2002
Query: 147 LRKSSFPETE------EKVRRL--------------------KRKNAELAVIAKRLEERA 180
RK++ E E E+ RRL KR AE A ++++
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREV--LRLQRQIALRNQRETLPLPPSWPPGP 238
++LQ+T L+ E +R R + E R+Q + R +
Sbjct: 2063 QELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 239 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 298
QA+A A A A + + + + E ++ Q ++E+ K +K E ++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 299 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQL--LG 352
+ ++ L LQL + ++ L EE RL ATE + QVE E +R Q+ L
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 353 VTQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEV 409
+ R A ++ L+ K + L++ + M++VA+ +L V ++A LR+ EE
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEED 2300
Query: 410 RRLQQAQAEAQ-REHEGAVQ----------LLESTLDSMQARVRELEEQCRSQTEQFSLL 458
Q+A AE +E AVQ LL+ + Q + R L+E +Q L
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---L 2357
Query: 459 AQELQAFR 466
A+E Q F+
Sbjct: 2358 AEETQGFQ 2365
Score = 60.1 bits (144), Expect = 2e-08
Identities = 113/467 (24%), Positives = 187/467 (40%), Gaps = 75/467 (16%)
Query: 48 AALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVE 107
A + Q+ +E ++ +G + V E AE L Q+ + G A QR E+
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEK--QRQLAEGTAQQRLAAEQEL 1715
Query: 108 AFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
L+A+ R LE L L++ A ++ Q E E ++ +++ +
Sbjct: 1716 IRLRAETEQGEQQRQLLE--EELARLQREAAAATQKRQ--------ELEAELAKVRAEME 1765
Query: 168 ELAVIAKRLEERARKLQETN---LRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ 224
L R EE +R E + L E ++ + + LR E R QRQ+A +
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR-QRQLAEEDA 1824
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEAT----------PQEDADNLPVI-LGEPEK 273
A R A A GEAT +++A+N + L E E
Sbjct: 1825 ARQR----------AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 274 EQRVQ----------QLESELSKKRKKCES-------LEQEARKKQRRCEE----LELQL 312
QR + +E L++ RK +S L ++ +++R+ EE L+
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 313 RQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 368
+A A L E R+ A + KEQ E E A R QL +E + +Q
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QL--AAEEERRRREAEERVQ 1991
Query: 369 SKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREKQEEVRRLQQAQAEAQRE----- 422
L + E+ + + + ++L+ + E+AR L R +QE R+LQ AQ AQ+
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 423 --HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
H AVQ E L + + + +Q R + E A+E + R+
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Score = 58.5 bits (140), Expect = 6e-08
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 67/353 (18%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
E+ AL + RQ L E + + + E +E +R++ + A +++ R +Q
Sbjct: 1364 EVEAALEKQRQ----LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLPLPPSWPPGPALQAR 243
E ++ ++ R ++R LR++ +I +R Q E G R
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 244 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQR 303
A A A + QE+A+ L + ++ QR +Q E EL+ R K E+ + AR+KQR
Sbjct: 1480 ARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RVKAEA--EAAREKQR 1533
Query: 304 ----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 353
+ EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE---------------- 1577
Query: 354 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 413
LQSK S A++ QLE ++ +++ + +EE R
Sbjct: 1578 -------------LQSKRASF----------AEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 414 QAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFSLLAQELQ 463
Q QAEA+R E A E L+ Q + E L Q +Q SL E +
Sbjct: 1615 QQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/461 (23%), Positives = 192/461 (41%), Gaps = 83/461 (18%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1112
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRG--------------- 1155
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR 210
+E RL++++ E V +R ER +L E +W V + QR
Sbjct: 1156 ----AQEVGERLQQRHGERDVEVERWRERVAQLLE--------RWQAVLAQTDV---RQR 1200
Query: 211 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 270
E+ +L RQ LR RE+ P G LQ QE +P+ +
Sbjct: 1201 ELEQLGRQ--LRYYRESAD-----PLGAWLQ-----------DARRRQEQIQAMPLADSQ 1242
Query: 271 PEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL---------------- 312
+EQ + Q L E+ + +K E ++ A++ ++ ELQL
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ-SKL 371
+ Q+ + +++E L +E + + + + L +E + + + + +L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-QEEVRRLQQAQAEAQRE----HEGA 426
+E L+ R++A+ Q + + E+ L+++ QEEV R ++A +AQ++ E
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 427 VQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
QL +S+ +QA+ R+ E RS+ + +E++ RL
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLR----IEEEIRVVRL 1459
Score = 50.1 bits (118), Expect = 2e-05
Identities = 92/371 (24%), Positives = 152/371 (40%), Gaps = 46/371 (12%)
Query: 107 EAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEE------NQMLRKSSFPETEEKVR 160
EA L++K SF ++ +L R+L E A L+EE Q + + E E ++
Sbjct: 1575 EAELQSK-RASFAEK-TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL---------LRESQRE 211
R + K E + + EE A++ E + R+ R RE +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 212 VLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEP 271
L QRQ+A ++ L A Q A GE Q + L + E
Sbjct: 1693 ELEKQRQLAEGTAQQRLA---------AEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 272 EKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEELELQLRQAQNENAR-LVEEN 326
Q+ Q+LE+EL+K R + E L + A ++ R E Q +A+ R L EE
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG---LQSKLESLEQVLKHMRE 383
+RL A E A+ + QL E D+A ++++ L KL ++ + + E
Sbjct: 1804 ARLRALA--------EEAKRQRQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 384 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
++ E E+E+ R ++ + RRL++ A+ + + E + L DS R +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911
Query: 444 LEEQCRSQTEQ 454
L E Q Q
Sbjct: 1912 LVEDTLRQRRQ 1922
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 67.0 bits (162), Expect = 2e-10
Identities = 83/364 (22%), Positives = 154/364 (42%), Gaps = 44/364 (12%)
Query: 133 LRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE---ERARKLQETNLR 189
LRQ + + L + E + V+ R AE ++ ++ E E+AR+LQE +
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 190 VEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAP 249
+ + F R L E++R QRQ+ + + E L L A +RA A A
Sbjct: 2357 MAQQLAEETQGFQRTL-EAER-----QRQLEMSAEAERLKLRV------AEMSRAQARA- 2403
Query: 250 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE 309
+EDA E +++ + E +K ++LE + ++ E L
Sbjct: 2404 --------EEDAQRFRK--QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453
Query: 310 LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGL 367
+ + + E +L +E L ++ E + V+ E Q L E+DS L++ + +
Sbjct: 2454 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513
Query: 368 QSKLESLEQVL---------------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
+ + LEQ+ + +++ Q RQ+L E+AR E +E VRR
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGP 471
Q+ + +++ +LL ++ +++ LEEQ R+ + A ++ A + P
Sbjct: 2574 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2633
Query: 472 LDLL 475
D L
Sbjct: 2634 RDAL 2637
Score = 65.1 bits (157), Expect = 6e-10
Identities = 104/428 (24%), Positives = 175/428 (40%), Gaps = 58/428 (13%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
LG+ S++ + E E+EA + +L R R E Q+ +EE
Sbjct: 1952 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEERVQKSLAAEEEAAR 2006
Query: 147 LRKSSFPETE------EKVRRL--------------------KRKNAELAVIAKRLEERA 180
RK++ E E E+ RRL KR AE A ++++
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREV--LRLQRQIALRNQRETLPLPPSWPPGP 238
++LQ+T L+ E +R R + E R+Q + R +
Sbjct: 2067 QELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 239 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 298
QA+A A A A + + + + E ++ Q ++E+ K +K E ++
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 299 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQL--LG 352
+ ++ L LQL + ++ L EE RL ATE + QVE E +R Q+ L
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 353 VTQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEV 409
+ R A ++ L+ K + L++ + M++VA+ +L V ++A LR+ EE
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEED 2304
Query: 410 RRLQQAQAEAQ-REHEGAVQ----------LLESTLDSMQARVRELEEQCRSQTEQFSLL 458
Q+A AE +E AVQ LL+ + Q + R L+E +Q L
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---L 2361
Query: 459 AQELQAFR 466
A+E Q F+
Sbjct: 2362 AEETQGFQ 2369
Score = 60.1 bits (144), Expect = 2e-08
Identities = 113/467 (24%), Positives = 187/467 (40%), Gaps = 75/467 (16%)
Query: 48 AALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVE 107
A + Q+ +E ++ +G + V E AE L Q+ + G A QR E+
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEK--QRQLAEGTAQQRLAAEQEL 1719
Query: 108 AFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
L+A+ R LE L L++ A ++ Q E E ++ +++ +
Sbjct: 1720 IRLRAETEQGEQQRQLLE--EELARLQREAAAATQKRQ--------ELEAELAKVRAEME 1769
Query: 168 ELAVIAKRLEERARKLQETN---LRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ 224
L R EE +R E + L E ++ + + LR E R QRQ+A +
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR-QRQLAEEDA 1828
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEAT----------PQEDADNLPVI-LGEPEK 273
A R A A GEAT +++A+N + L E E
Sbjct: 1829 ARQR----------AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 274 EQRVQ----------QLESELSKKRKKCES-------LEQEARKKQRRCEE----LELQL 312
QR + +E L++ RK +S L ++ +++R+ EE L+
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 313 RQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 368
+A A L E R+ A + KEQ E E A R QL +E + +Q
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QL--AAEEERRRREAEERVQ 1995
Query: 369 SKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREKQEEVRRLQQAQAEAQRE----- 422
L + E+ + + + ++L+ + E+AR L R +QE R+LQ AQ AQ+
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 423 --HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
H AVQ E L + + + +Q R + E A+E + R+
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Score = 58.5 bits (140), Expect = 6e-08
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 67/353 (18%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
E+ AL + RQ L E + + + E +E +R++ + A +++ R +Q
Sbjct: 1368 EVEAALEKQRQ----LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLPLPPSWPPGPALQAR 243
E ++ ++ R ++R LR++ +I +R Q E G R
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 244 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQR 303
A A A + QE+A+ L + ++ QR +Q E EL+ R K E+ + AR+KQR
Sbjct: 1484 ARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RVKAEA--EAAREKQR 1537
Query: 304 ----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 353
+ EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE---------------- 1581
Query: 354 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 413
LQSK S A++ QLE ++ +++ + +EE R
Sbjct: 1582 -------------LQSKRASF----------AEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 414 QAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFSLLAQELQ 463
Q QAEA+R E A E L+ Q + E L Q +Q SL E +
Sbjct: 1619 QQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/461 (23%), Positives = 192/461 (41%), Gaps = 83/461 (18%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1059 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1116
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRG--------------- 1159
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR 210
+E RL++++ E V +R ER +L E +W V + QR
Sbjct: 1160 ----AQEVGERLQQRHGERDVEVERWRERVAQLLE--------RWQAVLAQTDV---RQR 1204
Query: 211 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 270
E+ +L RQ LR RE+ P G LQ QE +P+ +
Sbjct: 1205 ELEQLGRQ--LRYYRESAD-----PLGAWLQ-----------DARRRQEQIQAMPLADSQ 1246
Query: 271 PEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL---------------- 312
+EQ + Q L E+ + +K E ++ A++ ++ ELQL
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ-SKL 371
+ Q+ + +++E L +E + + + + L +E + + + + +L
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-QEEVRRLQQAQAEAQRE----HEGA 426
+E L+ R++A+ Q + + E+ L+++ QEEV R ++A +AQ++ E
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 427 VQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
QL +S+ +QA+ R+ E RS+ + +E++ RL
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRLR----IEEEIRVVRL 1463
Score = 50.1 bits (118), Expect = 2e-05
Identities = 92/371 (24%), Positives = 152/371 (40%), Gaps = 46/371 (12%)
Query: 107 EAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEE------NQMLRKSSFPETEEKVR 160
EA L++K SF ++ +L R+L E A L+EE Q + + E E ++
Sbjct: 1579 EAELQSK-RASFAEK-TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL---------LRESQRE 211
R + K E + + EE A++ E + R+ R RE +
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 212 VLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEP 271
L QRQ+A ++ L A Q A GE Q + L + E
Sbjct: 1697 ELEKQRQLAEGTAQQRLA---------AEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 272 EKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEELELQLRQAQNENAR-LVEEN 326
Q+ Q+LE+EL+K R + E L + A ++ R E Q +A+ R L EE
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG---LQSKLESLEQVLKHMRE 383
+RL A E A+ + QL E D+A ++++ L KL ++ + + E
Sbjct: 1808 ARLRALA--------EEAKRQRQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 384 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
++ E E+E+ R ++ + RRL++ A+ + + E + L DS R +
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1915
Query: 444 LEEQCRSQTEQ 454
L E Q Q
Sbjct: 1916 LVEDTLRQRRQ 1926
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 67.0 bits (162), Expect = 2e-10
Identities = 83/364 (22%), Positives = 154/364 (42%), Gaps = 44/364 (12%)
Query: 133 LRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE---ERARKLQETNLR 189
LRQ + + L + E + V+ R AE ++ ++ E E+AR+LQE +
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 190 VEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAP 249
+ + F R L E++R QRQ+ + + E L L A +RA A A
Sbjct: 2353 MAQQLAEETQGFQRTL-EAER-----QRQLEMSAEAERLKLRV------AEMSRAQARA- 2399
Query: 250 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE 309
+EDA E +++ + E +K ++LE + ++ E L
Sbjct: 2400 --------EEDAQRFRK--QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 310 LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGL 367
+ + + E +L +E L ++ E + V+ E Q L E+DS L++ + +
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 368 QSKLESLEQVL---------------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
+ + LEQ+ + +++ Q RQ+L E+AR E +E VRR
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGP 471
Q+ + +++ +LL ++ +++ LEEQ R+ + A ++ A + P
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 472 LDLL 475
D L
Sbjct: 2630 RDAL 2633
Score = 65.1 bits (157), Expect = 6e-10
Identities = 104/428 (24%), Positives = 175/428 (40%), Gaps = 58/428 (13%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
LG+ S++ + E E+EA + +L R R E Q+ +EE
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEERVQKSLAAEEEAAR 2002
Query: 147 LRKSSFPETE------EKVRRL--------------------KRKNAELAVIAKRLEERA 180
RK++ E E E+ RRL KR AE A ++++
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREV--LRLQRQIALRNQRETLPLPPSWPPGP 238
++LQ+T L+ E +R R + E R+Q + R +
Sbjct: 2063 QELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 239 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 298
QA+A A A A + + + + E ++ Q ++E+ K +K E ++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 299 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQL--LG 352
+ ++ L LQL + ++ L EE RL ATE + QVE E +R Q+ L
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 353 VTQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEV 409
+ R A ++ L+ K + L++ + M++VA+ +L V ++A LR+ EE
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEED 2300
Query: 410 RRLQQAQAEAQ-REHEGAVQ----------LLESTLDSMQARVRELEEQCRSQTEQFSLL 458
Q+A AE +E AVQ LL+ + Q + R L+E +Q L
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---L 2357
Query: 459 AQELQAFR 466
A+E Q F+
Sbjct: 2358 AEETQGFQ 2365
Score = 60.1 bits (144), Expect = 2e-08
Identities = 113/467 (24%), Positives = 187/467 (40%), Gaps = 75/467 (16%)
Query: 48 AALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVE 107
A + Q+ +E ++ +G + V E AE L Q+ + G A QR E+
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEK--QRQLAEGTAQQRLAAEQEL 1715
Query: 108 AFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
L+A+ R LE L L++ A ++ Q E E ++ +++ +
Sbjct: 1716 IRLRAETEQGEQQRQLLE--EELARLQREAAAATQKRQ--------ELEAELAKVRAEME 1765
Query: 168 ELAVIAKRLEERARKLQETN---LRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ 224
L R EE +R E + L E ++ + + LR E R QRQ+A +
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR-QRQLAEEDA 1824
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEAT----------PQEDADNLPVI-LGEPEK 273
A R A A GEAT +++A+N + L E E
Sbjct: 1825 ARQR----------AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 274 EQRVQ----------QLESELSKKRKKCES-------LEQEARKKQRRCEE----LELQL 312
QR + +E L++ RK +S L ++ +++R+ EE L+
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 313 RQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 368
+A A L E R+ A + KEQ E E A R QL +E + +Q
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QL--AAEEERRRREAEERVQ 1991
Query: 369 SKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREKQEEVRRLQQAQAEAQRE----- 422
L + E+ + + + ++L+ + E+AR L R +QE R+LQ AQ AQ+
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 423 --HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
H AVQ E L + + + +Q R + E A+E + R+
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Score = 58.5 bits (140), Expect = 6e-08
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 67/353 (18%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
E+ AL + RQ L E + + + E +E +R++ + A +++ R +Q
Sbjct: 1364 EVEAALEKQRQ----LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLPLPPSWPPGPALQAR 243
E ++ ++ R ++R LR++ +I +R Q E G R
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 244 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQR 303
A A A + QE+A+ L + ++ QR +Q E EL+ R K E+ + AR+KQR
Sbjct: 1480 ARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RVKAEA--EAAREKQR 1533
Query: 304 ----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 353
+ EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE---------------- 1577
Query: 354 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 413
LQSK S A++ QLE ++ +++ + +EE R
Sbjct: 1578 -------------LQSKRASF----------AEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 414 QAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFSLLAQELQ 463
Q QAEA+R E A E L+ Q + E L Q +Q SL E +
Sbjct: 1615 QQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/461 (23%), Positives = 192/461 (41%), Gaps = 83/461 (18%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1112
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRG--------------- 1155
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR 210
+E RL++++ E V +R ER +L E +W V + QR
Sbjct: 1156 ----AQEVGERLQQRHGERDVEVERWRERVAQLLE--------RWQAVLAQTDV---RQR 1200
Query: 211 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 270
E+ +L RQ LR RE+ P G LQ QE +P+ +
Sbjct: 1201 ELEQLGRQ--LRYYRESAD-----PLGAWLQ-----------DARRRQEQIQAMPLADSQ 1242
Query: 271 PEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL---------------- 312
+EQ + Q L E+ + +K E ++ A++ ++ ELQL
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ-SKL 371
+ Q+ + +++E L +E + + + + L +E + + + + +L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-QEEVRRLQQAQAEAQRE----HEGA 426
+E L+ R++A+ Q + + E+ L+++ QEEV R ++A +AQ++ E
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 427 VQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
QL +S+ +QA+ R+ E RS+ + +E++ RL
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLR----IEEEIRVVRL 1459
Score = 50.1 bits (118), Expect = 2e-05
Identities = 92/371 (24%), Positives = 152/371 (40%), Gaps = 46/371 (12%)
Query: 107 EAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEE------NQMLRKSSFPETEEKVR 160
EA L++K SF ++ +L R+L E A L+EE Q + + E E ++
Sbjct: 1575 EAELQSK-RASFAEK-TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL---------LRESQRE 211
R + K E + + EE A++ E + R+ R RE +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 212 VLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEP 271
L QRQ+A ++ L A Q A GE Q + L + E
Sbjct: 1693 ELEKQRQLAEGTAQQRLA---------AEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 272 EKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEELELQLRQAQNENAR-LVEEN 326
Q+ Q+LE+EL+K R + E L + A ++ R E Q +A+ R L EE
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG---LQSKLESLEQVLKHMRE 383
+RL A E A+ + QL E D+A ++++ L KL ++ + + E
Sbjct: 1804 ARLRALA--------EEAKRQRQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 384 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
++ E E+E+ R ++ + RRL++ A+ + + E + L DS R +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911
Query: 444 LEEQCRSQTEQ 454
L E Q Q
Sbjct: 1912 LVEDTLRQRRQ 1922
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 67.0 bits (162), Expect = 2e-10
Identities = 83/364 (22%), Positives = 154/364 (42%), Gaps = 44/364 (12%)
Query: 133 LRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE---ERARKLQETNLR 189
LRQ + + L + E + V+ R AE ++ ++ E E+AR+LQE +
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 190 VEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAP 249
+ + F R L E++R QRQ+ + + E L L A +RA A A
Sbjct: 2321 MAQQLAEETQGFQRTL-EAER-----QRQLEMSAEAERLKLRV------AEMSRAQARA- 2367
Query: 250 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELE 309
+EDA E +++ + E +K ++LE + ++ E L
Sbjct: 2368 --------EEDAQRFRK--QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417
Query: 310 LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGL 367
+ + + E +L +E L ++ E + V+ E Q L E+DS L++ + +
Sbjct: 2418 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477
Query: 368 QSKLESLEQVL---------------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412
+ + LEQ+ + +++ Q RQ+L E+AR E +E VRR
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 413 QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGP 471
Q+ + +++ +LL ++ +++ LEEQ R+ + A ++ A + P
Sbjct: 2538 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2597
Query: 472 LDLL 475
D L
Sbjct: 2598 RDAL 2601
Score = 65.1 bits (157), Expect = 6e-10
Identities = 104/428 (24%), Positives = 175/428 (40%), Gaps = 58/428 (13%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQM 146
LG+ S++ + E E+EA + +L R R E Q+ +EE
Sbjct: 1916 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEERVQKSLAAEEEAAR 1970
Query: 147 LRKSSFPETE------EKVRRL--------------------KRKNAELAVIAKRLEERA 180
RK++ E E E+ RRL KR AE A ++++
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Query: 181 RKLQETNLRVEGPQWLHVRDFDRLLRESQREV--LRLQRQIALRNQRETLPLPPSWPPGP 238
++LQ+T L+ E +R R + E R+Q + R +
Sbjct: 2031 QELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 239 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 298
QA+A A A A + + + + E ++ Q ++E+ K +K E ++
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 299 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQL--LG 352
+ ++ L LQL + ++ L EE RL ATE + QVE E +R Q+ L
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 353 VTQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEV 409
+ R A ++ L+ K + L++ + M++VA+ +L V ++A LR+ EE
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEED 2268
Query: 410 RRLQQAQAEAQ-REHEGAVQ----------LLESTLDSMQARVRELEEQCRSQTEQFSLL 458
Q+A AE +E AVQ LL+ + Q + R L+E +Q L
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---L 2325
Query: 459 AQELQAFR 466
A+E Q F+
Sbjct: 2326 AEETQGFQ 2333
Score = 60.1 bits (144), Expect = 2e-08
Identities = 113/467 (24%), Positives = 187/467 (40%), Gaps = 75/467 (16%)
Query: 48 AALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVE 107
A + Q+ +E ++ +G + V E AE L Q+ + G A QR E+
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAV--RQRELAEQELEK--QRQLAEGTAQQRLAAEQEL 1683
Query: 108 AFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA 167
L+A+ R LE L L++ A ++ Q E E ++ +++ +
Sbjct: 1684 IRLRAETEQGEQQRQLLE--EELARLQREAAAATQKRQ--------ELEAELAKVRAEME 1733
Query: 168 ELAVIAKRLEERARKLQETN---LRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQ 224
L R EE +R E + L E ++ + + LR E R QRQ+A +
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR-QRQLAEEDA 1792
Query: 225 RETLPLPPSWPPGPALQARAGAPAPGAPGEAT----------PQEDADNLPVI-LGEPEK 273
A R A A GEAT +++A+N + L E E
Sbjct: 1793 ARQR----------AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 274 EQRVQ----------QLESELSKKRKKCES-------LEQEARKKQRRCEE----LELQL 312
QR + +E L++ RK +S L ++ +++R+ EE L+
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 313 RQAQNENARLVEENSRLSGRATE----KEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 368
+A A L E R+ A + KEQ E E A R QL +E + +Q
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QL--AAEEERRRREAEERVQ 1959
Query: 369 SKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREKQEEVRRLQQAQAEAQRE----- 422
L + E+ + + + ++L+ + E+AR L R +QE R+LQ AQ AQ+
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 423 --HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
H AVQ E L + + + +Q R + E A+E + R+
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066
Score = 58.5 bits (140), Expect = 6e-08
Identities = 89/353 (25%), Positives = 144/353 (40%), Gaps = 67/353 (18%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
E+ AL + RQ L E + + + E +E +R++ + A +++ R +Q
Sbjct: 1332 EVEAALEKQRQ----LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 185 ETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLPLPPSWPPGPALQAR 243
E ++ ++ R ++R LR++ +I +R Q E G R
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 244 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQR 303
A A A + QE+A+ L + ++ QR +Q E EL+ R K E+ + AR+KQR
Sbjct: 1448 ARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RVKAEA--EAAREKQR 1501
Query: 304 ----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 353
+ EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE---------------- 1545
Query: 354 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 413
LQSK S A++ QLE ++ +++ + +EE R
Sbjct: 1546 -------------LQSKRASF----------AEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 414 QAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFSLLAQELQ 463
Q QAEA+R E A E L+ Q + E L Q +Q SL E +
Sbjct: 1583 QQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/461 (23%), Positives = 192/461 (41%), Gaps = 83/461 (18%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1023 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1080
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRG--------------- 1123
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQR 210
+E RL++++ E V +R ER +L E +W V + QR
Sbjct: 1124 ----AQEVGERLQQRHGERDVEVERWRERVAQLLE--------RWQAVLAQTDV---RQR 1168
Query: 211 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 270
E+ +L RQ LR RE+ P G LQ QE +P+ +
Sbjct: 1169 ELEQLGRQ--LRYYRESAD-----PLGAWLQ-----------DARRRQEQIQAMPLADSQ 1210
Query: 271 PEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL---------------- 312
+EQ + Q L E+ + +K E ++ A++ ++ ELQL
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 313 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ-SKL 371
+ Q+ + +++E L +E + + + + L +E + + + + +L
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 372 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-QEEVRRLQQAQAEAQRE----HEGA 426
+E L+ R++A+ Q + + E+ L+++ QEEV R ++A +AQ++ E
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 427 VQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 467
QL +S+ +QA+ R+ E RS+ + +E++ RL
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRLR----IEEEIRVVRL 1427
Score = 50.1 bits (118), Expect = 2e-05
Identities = 92/371 (24%), Positives = 152/371 (40%), Gaps = 46/371 (12%)
Query: 107 EAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEE------NQMLRKSSFPETEEKVR 160
EA L++K SF ++ +L R+L E A L+EE Q + + E E ++
Sbjct: 1543 EAELQSK-RASFAEK-TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRL---------LRESQRE 211
R + K E + + EE A++ E + R+ R RE +
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 212 VLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEP 271
L QRQ+A ++ L A Q A GE Q + L + E
Sbjct: 1661 ELEKQRQLAEGTAQQRLA---------AEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 272 EKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEELELQLRQAQNENAR-LVEEN 326
Q+ Q+LE+EL+K R + E L + A ++ R E Q +A+ R L EE
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 327 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG---LQSKLESLEQVLKHMRE 383
+RL A E A+ + QL E D+A ++++ L KL ++ + + E
Sbjct: 1772 ARLRALA--------EEAKRQRQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 384 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 443
++ E E+E+ R ++ + RRL++ A+ + + E + L DS R +
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1879
Query: 444 LEEQCRSQTEQ 454
L E Q Q
Sbjct: 1880 LVEDTLRQRRQ 1890
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,724,817
Number of Sequences: 37866
Number of extensions: 6234632
Number of successful extensions: 78301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 748
Number of HSP's successfully gapped in prelim test: 2697
Number of HSP's that attempted gapping in prelim test: 36473
Number of HSP's gapped (non-prelim): 30589
length of query: 1797
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1680
effective length of database: 13,817,196
effective search space: 23212889280
effective search space used: 23212889280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.