Guide to the Human Genome
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Search of human proteins with 170016061

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
         (3639 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]       7109   0.0  
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          936   0.0  
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   930   0.0  
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   929   0.0  
gi|67782321 spectrin beta isoform a [Homo sapiens]                    879   0.0  
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   872   0.0  
gi|67782319 spectrin beta isoform b [Homo sapiens]                    869   0.0  
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   643   0.0  
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   637   0.0  
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]           567   e-161
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        358   4e-98
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       357   9e-98
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       357   9e-98
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        357   9e-98
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        357   9e-98
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        357   9e-98
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        357   9e-98
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        357   9e-98
gi|4501893 actinin, alpha 2 [Homo sapiens]                            346   3e-94
gi|33188445 microfilament and actin filament cross-linker protei...   345   5e-94
gi|4557241 actinin, alpha 3 [Homo sapiens]                            345   5e-94
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]                344   1e-93
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]                344   1e-93
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                  344   1e-93
gi|12025678 actinin, alpha 4 [Homo sapiens]                           338   7e-92
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [...   269   4e-71
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   254   1e-66
gi|221316624 dystonin isoform 4 [Homo sapiens]                        222   5e-57
gi|221316622 dystonin isoform 3 [Homo sapiens]                        222   5e-57
gi|221316618 dystonin isoform 2 [Homo sapiens]                        222   5e-57

>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score = 7109 bits (18445), Expect = 0.0
 Identities = 3639/3639 (100%), Positives = 3639/3639 (100%)

Query: 1    MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE 60
            MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE
Sbjct: 1    MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE 60

Query: 61   LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII 120
            LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII
Sbjct: 61   LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII 120

Query: 121  LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL 180
            LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL
Sbjct: 121  LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL 180

Query: 181  IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS 240
            IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS
Sbjct: 181  IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS 240

Query: 241  LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP 300
            LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP
Sbjct: 241  LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP 300

Query: 301  DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE 360
            DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE
Sbjct: 301  DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE 360

Query: 361  LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP 420
            LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP
Sbjct: 361  LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP 420

Query: 421  PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480
            PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW
Sbjct: 421  PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480

Query: 481  QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540
            QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH
Sbjct: 481  QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540

Query: 541  DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL
Sbjct: 541  DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600

Query: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
            EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC
Sbjct: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660

Query: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
            VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA
Sbjct: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720

Query: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
            EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA
Sbjct: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
            SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS
Sbjct: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840

Query: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK 900
            QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK
Sbjct: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK 900

Query: 901  YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960
            YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ
Sbjct: 901  YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960

Query: 961  LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL 1020
            LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL
Sbjct: 961  LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL 1020

Query: 1021 QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL 1080
            QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL
Sbjct: 1021 QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL 1080

Query: 1081 LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140
            LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD
Sbjct: 1081 LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN 1200
            SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN
Sbjct: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN 1200

Query: 1201 LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ 1260
            LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ
Sbjct: 1201 LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ 1260

Query: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH 1320
            WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH
Sbjct: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH 1320

Query: 1321 EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL 1380
            EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL
Sbjct: 1321 EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL 1380

Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM 1440
            QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM
Sbjct: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM 1440

Query: 1441 AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
            AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW
Sbjct: 1441 AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500

Query: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
            VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ
Sbjct: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560

Query: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG 1620
            HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG
Sbjct: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG 1620

Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680
            RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL
Sbjct: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680

Query: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
            QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK
Sbjct: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740

Query: 1741 FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD 1800
            FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD
Sbjct: 1741 FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD 1800

Query: 1801 TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
            TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL
Sbjct: 1801 TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860

Query: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
            LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY
Sbjct: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920

Query: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
            ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT
Sbjct: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980

Query: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
            PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040

Query: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
            ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100

Query: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
            ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE
Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160

Query: 2161 AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
            AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR
Sbjct: 2161 AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
            NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR
Sbjct: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
            SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN
Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP
Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT 2460
            EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT
Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT 2460

Query: 2461 SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
            SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE
Sbjct: 2461 SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520

Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
            QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL
Sbjct: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580

Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
            WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR
Sbjct: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640

Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH 2700
            HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH
Sbjct: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH 2700

Query: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760
            QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS
Sbjct: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760

Query: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
            MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR
Sbjct: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820

Query: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
            EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL
Sbjct: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880

Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
            AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ
Sbjct: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940

Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
            QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ
Sbjct: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060

Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
            ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ
Sbjct: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120

Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
            SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH
Sbjct: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180

Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
            SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA
Sbjct: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240

Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
            CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE
Sbjct: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300

Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
            LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360

Query: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
            QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV
Sbjct: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420

Query: 3421 ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ 3480
            ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ
Sbjct: 3421 ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ 3480

Query: 3481 GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD 3540
            GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD
Sbjct: 3481 GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD 3540

Query: 3541 ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA 3600
            ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA
Sbjct: 3541 ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA 3600

Query: 3601 LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP 3639
            LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP
Sbjct: 3601 LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP 3639


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  936 bits (2418), Expect = 0.0
 Identities = 644/2109 (30%), Positives = 1031/2109 (48%), Gaps = 91/2109 (4%)

Query: 5    YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
            +E   I+ L      +Q+KTFTKW+N+     +   ++ +LY++L DG +LLRLLE++SG
Sbjct: 43   FERSRIKALADEREAVQKKTFTKWVNS--HLARVTCRVGDLYSDLRDGRNLLRLLEVLSG 100

Query: 65   EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
            E LP P++GR+R+H LEN  +AL FL+  KV +  +G  +IVDG+  L LGL+W IILRF
Sbjct: 101  EILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRF 160

Query: 124  QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
            QI  IS++ E+   +    S K+ALL+WCQ KTA Y NVN+ +F+ SW DGL FNA++H 
Sbjct: 161  QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHK 217

Query: 184  HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
            HRPDLLD+ SL+     +NL  AF +AE+ELG+ +LLDPEDV   QPDE+SI+TYV+ YY
Sbjct: 218  HRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYY 277

Query: 244  HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
            HY S++       +R+ K+L    E E L  +YE L ++LL+WI +  + L  R   +SL
Sbjct: 278  HYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSL 337

Query: 304  PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
              ++  L +F  +RT EKPP+  ++G  E LLF +Q+ L+A N++ + P EG  ++++++
Sbjct: 338  SGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINK 397

Query: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
             W  LE AE  R  AL+  L++ ++LE LA RF  KAA+RE++L + ++++ Q       
Sbjct: 398  AWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNF-GLE 456

Query: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
            LA VEAAV++   +E  I+   GR QA+  +A  L  E+YH    +A RQ  V   W  L
Sbjct: 457  LAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL 516

Query: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
             Q +  +R+++     +  + Q++      +EE++   +S   G+ LA V +LLQ H+L+
Sbjct: 517  RQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELV 576

Query: 544  EAQVSAHGAHVSHLAQQTAEL----DSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
            EA ++     V  ++                  +++  +   L Q  ++L  L  ARRA 
Sbjct: 577  EADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636

Query: 600  LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
            LE++ +   FL    E EAW++E    + +A  GRDL+     L KH AL  E+      
Sbjct: 637  LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGP 696

Query: 660  CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
                + +G+ L A   P       RA  +Q  W+ L+     R  RL  A  + Q+ ADA
Sbjct: 697  LKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA 756

Query: 720  AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
             +  +WL +    +     G D+ + + L R+H  LE  +R+    L  L EQ       
Sbjct: 757  NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQ------- 809

Query: 780  ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
                   +A  PP                          L   P+      T       L
Sbjct: 810  -------AAALPP-------------------------TLSRTPEVQGRVPT-------L 830

Query: 840  SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ--RVQPQADTLEVM 897
             + YE L+A A  R   LE A+AL+   S  G   LW+E++   L    +  + + LEV+
Sbjct: 831  ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 890

Query: 898  QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
            Q ++E     +         V+  AEQL +  P    +I   QE+L+ RW Q   L   K
Sbjct: 891  QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950

Query: 958  AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017
               L  ++ + ++  EC  TQ  +R+    +E+ Q G   D    L L Q+K    ER +
Sbjct: 951  KAALTSALSIQNYHLECTETQAWMREKTKVIESTQ-GLGNDLAGVLAL-QRKLAGTERDL 1008

Query: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQE-----QVAQRARRQAETQAR--Q 1070
              + + V ++     A +     Q   +   L++VQ      +   R R ++  +AR  Q
Sbjct: 1009 EAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ 1068

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQS 1130
             FL+       W    Q  + S+E    +  A+ LL +H  L  E+   Q    +L A  
Sbjct: 1069 DFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128

Query: 1131 QPMAALDC-PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
            + +      P    +   L  LG   +EL  +WE RQ  L +    Q F R+        
Sbjct: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188

Query: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
            ++ +  L    +   ++ A + +++  +F   +   G R   L   G +LV   +  A  
Sbjct: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248

Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
            +RE+  SI+ +  + Q  ++Q   +L  + + Q + QD  EL  W++EK L A       
Sbjct: 1249 IREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE 1308

Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
             RN+    ++H+A  +EL A +  ++ + + GREL   +P  +  +  +L+ L  +W+ L
Sbjct: 1309 ARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDEL 1368

Query: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
                  +   L  A + E   +     +  LE L+  L S + G+DL S   L K+ Q L
Sbjct: 1369 ETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML 1428

Query: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLE----LLQGHLAIRGLQLQASV 1485
            E E      ++ A+ + A  +A       E ++  R +E     L   +  R  +LQAS 
Sbjct: 1429 EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488

Query: 1486 ELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
            E HQF      E+ WV E +P  S   + + L   Q L +K++ LQ E++ H+ ++  + 
Sbjct: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548

Query: 1546 SSGRSL-AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELE 1604
               R+L AA+  P       +  EL+  W  L    E R + L+ A+  QQ++ D +E E
Sbjct: 1549 ERQRALGAAAAGP-------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601

Query: 1605 GWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE 1664
             W+ E+   +  ++  +DE +    + KHQ L++ LA Y  ++ +L  ++Q +   E PE
Sbjct: 1602 AWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPE 1661

Query: 1665 QQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
              R+   Q ++ +    L+ELA  R   L+  LRL +  RE +DL+ W+  +++      
Sbjct: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI-QEREVVAASH 1720

Query: 1723 SLGEDPEHALHLCTKFAKFQHQVE-MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQ 1781
             LG+D EH   L  KF +F      +G +RV +   LA  L+  GH+A   V + +  L 
Sbjct: 1721 ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLN 1780

Query: 1782 TAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLR 1841
             AW++L EL   RG  L       R      + L +VQ K   LP+   RDL   EA  R
Sbjct: 1781 EAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840

Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901
             H   E ++     Q+Q++ +   R+QK   G +A  + +  QAV +AWA LQ     RR
Sbjct: 1841 RHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARR 1900

Query: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
              L       RF  AVR+   W   V   +  +E  ++ SS  L +   Q ++AE+EAR 
Sbjct: 1901 QLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARA 1960

Query: 1962 KLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
              +     +G++ L  +    +E+ E+L  LQ +R +  + W  K + LQ   +  +F R
Sbjct: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGR 2020

Query: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQD------KKEAALRE 2075
            + G  E  L +QE  ++++ LG +V+EVE LI++HE F K   A +      +K  AL E
Sbjct: 2021 DAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080

Query: 2076 RLKTLRRPR 2084
            R K  +R R
Sbjct: 2081 REKERKRKR 2089



 Score =  499 bits (1284), Expect = e-140
 Identities = 425/1715 (24%), Positives = 754/1715 (43%), Gaps = 70/1715 (4%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW  L +    R  ALR    T  + ++ LE L    ++  ++             
Sbjct: 394  DINKAWERLEKAEHERELALR----TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVS 449

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
             +N   +L  +EA +R H+ +E ++V    ++Q +   A  +       + H +++   R
Sbjct: 450  QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA----AERYHDIKRIAAR 505

Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
            Q  V + W  L++ +  RR +L     L +    +     W   ++  LQ ++  +  + 
Sbjct: 506  QHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAG 565

Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE--------VQEELRALQD 1994
                L  H+ + A++  +     +  +    + L    P KE        V E +  L+ 
Sbjct: 566  VEDLLQLHELVEADIAVQA----ERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQ 621

Query: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
              + + +  A ++ RL+  ++   FL E G  E  +  Q+  L ++  G  +    +L+ 
Sbjct: 622  SYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLN 681

Query: 2055 KHEVF----------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
            KH             LK+   Q ++  A      +    R  +    L  +  R++ LAE
Sbjct: 682  KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAE----LQAQWERLEALAE 737

Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
             R   L  +  +  F   A   E W+    + +  P    D         +H+A E E++
Sbjct: 738  ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIR 797

Query: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLE 2224
            +H   + ++ ++  AL   +  R  EV  R+  L +H+E+L+     R + LE       
Sbjct: 798  SHRPTLDALREQAAAL-PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYT 856

Query: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISD 2284
             L        W++EKE  +N   L + LE    +++R          +T+  A I +++D
Sbjct: 857  MLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM--NTLA-AQITAVND 913

Query: 2285 LSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKR 2344
            ++ QL   +P     I   + QLN+RW  F       +  L  AL I     E       
Sbjct: 914  IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973

Query: 2345 IQEKEALIQALD-CGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
            ++EK  +I++    G DL  V  L RK    ER++  I A+V  L RE   L    P  A
Sbjct: 974  MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQA 1033

Query: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPA 2463
              +  R +EV   W  LR+  ++R E+L    + Q     L +      R +  + +   
Sbjct: 1034 VAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEG 1093

Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT-AGHPFSSDIRQVLAGLEQE 2522
            P +  EA  +L +H   + E++      S  R+ G+++      P    +RQ L  L   
Sbjct: 1094 PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTG 1153

Query: 2523 LSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWK 2582
               L   W+  Q +L QA   Q FL    + E  L S+E  L+   +   L   +  + K
Sbjct: 1154 WEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKK 1213

Query: 2583 HKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR 2642
             +     ++    +I  L    R L   G+  A     +  ++  R +     A     R
Sbjct: 1214 LEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGR 1273

Query: 2643 LEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ 2702
            L + R+ Q FLQD  E+  W+ EK L A +    +   L  + QK Q F AEL A+    
Sbjct: 1274 LRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWL 1333

Query: 2703 QELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME 2762
             ++ +EG+ L          + E+L +L   W EL+  +Q K   L  A  A    +S  
Sbjct: 1334 DKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCC 1393

Query: 2763 ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG 2822
             LE+WLE ++ +L +   G+ L  V  LL  Q+ LE  +  + ++ EA+  QA+A  +E 
Sbjct: 1394 ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453

Query: 2823 HCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAA 2882
               A +VE  +R + ++F++L +P++ER   L+A     +F RD ++E+ WV E+LP+A+
Sbjct: 1454 QG-AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMAS 1512

Query: 2883 AQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL 2942
            + ++G+ L +V+ L +++Q L+ E+  HE     +     +    G  AA    A +Q++
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPR---IADLRERQRALGAAAAGPELAELQEM 1569

Query: 2943 EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
             K + H   E   R   L+ A  AQQF  +  EA +W+ E+   +  ++      + QA 
Sbjct: 1570 WKRLGH---ELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAE 1626

Query: 3003 LRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEAR 3062
            +++ +  ++ L  ++  I +L  ++  +   ++PES ++  +   V + +A L   A  R
Sbjct: 1627 VKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGER 1686

Query: 3063 GHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
               LQE L+L QL RE   L+ W+  +   A S + GQD E V +L +KF  F ++  ++
Sbjct: 1687 RERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTI 1746

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSF 3182
            GQ +V +   LA  L  G       +   +  +  AW  L + +  R + LAAA+E+  F
Sbjct: 1747 GQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRF 1806

Query: 3183 QQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACR 3242
               A +   R+Q K   +  +  G  L++   LQ++H   E +++A+  +V ++Q +  R
Sbjct: 1807 LHGARQALARVQHKQQQLP-DGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHR 1865

Query: 3243 LGQLHPAAPG-----GLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQE 3297
            L + +           +  V EAWA LQ  +  R Q L        F    +EL+ W  E
Sbjct: 1866 LQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925

Query: 3298 RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVT 3357
                  ++E   DV+ A+ ++   + +  EI     +       G++L+  SH+ + E++
Sbjct: 1926 VNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEIS 1985

Query: 3358 ECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSV 3417
            E L +L+ R QE  E W  +         +    +    AEAWL   E L+   + G +V
Sbjct: 1986 EKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2045

Query: 3418 SDVELLLHRHQDLEKLLAAQEEKFAQMQK-TEMEQ 3451
             +VE L+ RH+  +K   A EE+F  ++K T +E+
Sbjct: 2046 DEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080



 Score =  431 bits (1109), Expect = e-120
 Identities = 407/1782 (22%), Positives = 760/1782 (42%), Gaps = 87/1782 (4%)

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQ--LQSIQAQWTRLQGRSEQRRRQ 1274
            E G L   L      LRA+ +K+        +T RE   +  I   W RL+    +R   
Sbjct: 361  EKGNLEVLLFTIQSKLRANNQKV--------YTPREGRLISDINKAWERLEKAEHERELA 412

Query: 1275 LLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHEPSGARRNILQT-LKRHEAAES 1325
            L   L  QE  + +A            W+ E   + + +  G     ++  +++HEA E+
Sbjct: 413  LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472

Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
            +++A    V+A+  V  EL + R    + I  R   +   W+ L + +  R + L    +
Sbjct: 473  DIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLE 532

Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
             +++ + L    + +E+++G LQS + G+ L   + L + H+ +E++    A ++ A+++
Sbjct: 533  LQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSA 592

Query: 1446 MA-----HGMAASPA----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNM 1496
             A      G    P     + E   K  +  E L    A R  +L+ S  L +F      
Sbjct: 593  SALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGE 652

Query: 1497 ELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGH 1556
              +WV E     +       L GA  L  KH  L+ E+    G ++  L  G+ L A GH
Sbjct: 653  AEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGH 712

Query: 1557 PQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
            P A     +  EL+  W  LE   E RAQ L QA +  Q+  D +++E W+ +   LVSS
Sbjct: 713  PGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSS 772

Query: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLR 1674
             + G DE +T  L  +H+AL+EE+  +  +++ L + A  L  T    PE Q  V   L 
Sbjct: 773  PELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRV-PTLE 831

Query: 1675 EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHL 1734
                 LQ  A  R R LE  L L+  L EA     W+  +K+    G +L E  E    +
Sbjct: 832  RHYEELQARAGERARALEAALALYTMLSEAGACGLWV-EEKEQWLNGLALPERLEDLEVV 890

Query: 1735 CTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR 1794
              +F   + ++   + ++ A   +AE LL+        +   Q+ L   W +   L   +
Sbjct: 891  QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950

Query: 1795 GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTE 1854
              AL    +    H +  E    ++EK       V     GL   L     L+R+L GTE
Sbjct: 951  KAALTSALSIQNYHLECTETQAWMREK-----TKVIESTQGLGNDLAGVLALQRKLAGTE 1005

Query: 1855 RQLQELLETAGRVQK----LCPG--PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR 1908
            R L+ +    G + +    L  G   QA A+  R + V   W  L+  M +R   L  AR
Sbjct: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065

Query: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
             L  F  ++ D+ +W  R +  +  EE           L+ H  LR E+E  +  + +  
Sbjct: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125

Query: 1969 QLGQQALLAAGTP-TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
             LG++       P    +++ L AL    +++ + W  +Q RL      Q FLR+  + E
Sbjct: 1126 ALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAE 1185

Query: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------R 2081
             +L++QE  L  + +  +++  +  I+K E F+  + A  ++   L E  + L       
Sbjct: 1186 GVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIH 1245

Query: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
              ++R++   + +R  + ++ A+     L  +     F Q   + + WI        + V
Sbjct: 1246 ADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE-KMLTAQDV 1304

Query: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
               + R+      KHQAF AE+ A+++ +  V K+G  L  +       VS++L+ L + 
Sbjct: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRR 1364

Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
            W++L      + + L D      F Q     E+W++  + +++  D G+DL     L ++
Sbjct: 1365 WDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKK 1424

Query: 2262 LREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRY 2321
             +      A   V +  + +I   +  L   D    ++    R+ +  ++ +    +   
Sbjct: 1425 QQMLEWEMA---VREKEVEAIQAQAKALAQEDQGAGEVERTSRA-VEEKFRALCQPMRER 1480

Query: 2322 QQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREV--- 2378
             ++L+ + E H   R++++    + E+  +  +++ GKDL SVQ L++K++ L++E+   
Sbjct: 1481 CRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGH 1540

Query: 2379 HPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQ 2438
             P  A +   +R +G      PE A        E+ E W +L    + R + L+   +AQ
Sbjct: 1541 EPRIADLRERQRALG-AAAAGPELA--------ELQEMWKRLGHELELRGKRLEDALRAQ 1591

Query: 2439 KLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTG 2498
            +      E           M      +  + A+  +++HQ  +  L  +  +I    ++ 
Sbjct: 1592 QFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASS 1651

Query: 2499 QQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLC 2558
            Q ++   HP S+ I    A +++  + L+    E + +LQ+ L L      ++ +E+W+ 
Sbjct: 1652 QDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQ 1711

Query: 2559 SKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEATARGLHQGGHPEAQS 2617
             +E   AS  L      +  L  K +    D   +   ++ +  A A GL  GGH  A++
Sbjct: 1712 EREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH-AARA 1770

Query: 2618 ALGRCQAMLLRKEA-LFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL 2676
             +   +  L    A L     TR   L    +LQ FL  +++  A ++ K     +    
Sbjct: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR 1830

Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWG 2735
            D     A  ++   ++ ++ A   Q Q++Q +G RL +      +E I   ++ +   W 
Sbjct: 1831 DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWA 1890

Query: 2736 ELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQR 2795
            +LQ +S  +   L    +  R  +++ EL  W++ + +++ A    + +     ++  Q+
Sbjct: 1891 QLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950

Query: 2796 ELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALE 2855
             ++A ++ +A +  + +   +  +   H  A+++ E+  +L  R +   E  QE+   L+
Sbjct: 1951 GIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQ 2010

Query: 2856 ARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
                +L F RDA    AW+  + PL  + + G ++  V  L ++H+  +    + E    
Sbjct: 2011 LVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--- 2067

Query: 2916 VVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957
                          F A E    +++ EK     R E  RR+
Sbjct: 2068 -------------RFCALEKLTALEEREKERKRKREEEERRK 2096



 Score =  335 bits (858), Expect = 6e-91
 Identities = 397/1733 (22%), Positives = 699/1733 (40%), Gaps = 154/1733 (8%)

Query: 596  RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV-- 653
            R+  LEQ   R  F R     E WL E  + V     G +L+ +  A++KH+A+E ++  
Sbjct: 419  RQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476

Query: 654  HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
            +  +   VD V    +L+A R         R   V   W  L+  V  R  RL   L + 
Sbjct: 477  YSGRVQAVDAV--AAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534

Query: 714  QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
            + F D      W+ E +  L+    G+  A  E LL+ H  +E       A++    E+ 
Sbjct: 535  KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVE-------ADIAVQAERV 587

Query: 774  RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
            RA SA A  F                       C+PG     K   P       DP  + 
Sbjct: 588  RAVSASALRF-----------------------CNPG-----KEYRPC------DPQLVS 613

Query: 834  QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADT 893
            +    L Q YE+L  LA  RRARLEE+  L+ F    GE + W+ +Q  LL       D 
Sbjct: 614  ERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDL 673

Query: 894  LEVMQLKYENFLTAL-AVGKGLWAEVSSSAEQ----LRQRYPGNSTQIQRQQEELSQRWG 948
               ++L   N  TAL     G    +  + EQ    + + +PG ++Q   +  EL  +W 
Sbjct: 674  TGALRLL--NKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG-ASQASARAAELQAQWE 730

Query: 949  QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQK 1008
            +LEAL  E+A +LA +  +  F  +    +  L D L  + + + G  E +  AL   Q 
Sbjct: 731  RLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL-ARQH 789

Query: 1009 KTLVLERRVHFLQSVVVKVE----EPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
            + L  E R H      ++ +     P  + +  +QG+V TL+   +++Q +  +RAR   
Sbjct: 790  RALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALE 849

Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
               A  + L E+    LW E  +  L    +   +   + + +  + L  E++    ++ 
Sbjct: 850  AALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQIT 909

Query: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
             ++  ++ +   + P    + NT   L  + Q+ + L + ++  L   L +Q +  E   
Sbjct: 910  AVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLE--- 966

Query: 1185 FTATCANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHG 1236
                C   QAW+            LG D+   L+L ++     R L  +  R   L    
Sbjct: 967  ----CTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREA 1022

Query: 1237 EKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM- 1295
              L       A  +  +L+ +Q  W  L+    +R   L  + +LQ++ + + +   W+ 
Sbjct: 1023 NALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLG 1082

Query: 1296 EEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQ-ED 1354
              +  +A+ E           L +H A   E+   +     L+ +G E+   +   Q   
Sbjct: 1083 RTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142

Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414
            ++ RL+ L + WE L R    R   L QA   +  LR  + A+  L   E  L  +E   
Sbjct: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202

Query: 1415 DLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHLR 1465
             L+++    K+ +   S       ++  L       ++ G   +  I E+     ++H +
Sbjct: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262

Query: 1466 RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH- 1524
              +  Q  L     +L+ + E   F    +    W+ E M      SY E    A++LH 
Sbjct: 1263 NQDAAQQFLG----RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE----ARNLHT 1314

Query: 1525 --RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEA 1582
              +KH+    E+ A++  + +V   GR L          + E+ ++L   W ELE   +A
Sbjct: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQA 1374

Query: 1583 RAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAI 1642
            +A+ L  A   + +      LE W+E  +  + S DYG+D  +   L+ K Q L+ E+A+
Sbjct: 1375 KARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAV 1434

Query: 1643 YWSSMEELDQTAQTLT-----GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRL 1697
                +E +   A+ L        EV    R V+E+ R   + ++E    R R L+ +   
Sbjct: 1435 REKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE----RCRRLQASREQ 1490

Query: 1698 HEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRL 1757
            H+F R+ ED   W+  +   A   E  G+D      L  K    Q +++    R+A  R 
Sbjct: 1491 HQFHRDVEDEILWVTERLPMASSMEH-GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRE 1549

Query: 1758 LAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
               +L     +AGP +     +LQ  W  L    + RG  L D     + +RD  E    
Sbjct: 1550 RQRAL--GAAAAGPEL----AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAW 1603

Query: 1818 V-QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLC--PGP 1874
            + +++   +    A+D    +A+++ HQ LE+ L    + + +L   A   Q +     P
Sbjct: 1604 MGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQL---AASSQDMIDHEHP 1660

Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVE 1934
            ++  +  RQ  V + +A L+    +RR +L+    L + R  + D   W     Q+ +V 
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI----QEREVV 1716

Query: 1935 ESSQEPSSG-----PLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEEL 1989
             +S E          L+    ++ R      ++    A  L    L+A G   +      
Sbjct: 1717 AASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALA-NGLIAGGHAAR------ 1769

Query: 1990 RALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEIL-----AAQEVSLKTSAL-- 2042
              + + +D + + WA   E L    Q    L     L+  L     A   V  K   L  
Sbjct: 1770 ATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYELQRFLHGARQALARVQHKQQQLPD 1826

Query: 2043 --GSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
              G  +   E L R+H  +   + A   +   +++    L++    D+   + +    V 
Sbjct: 1827 GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVA 1886

Query: 2101 EL-AESRG-HALHASLLMAS-----FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
            E  A+ +G  A    LL+ +     F +A  +   W+     Q+     P D+      +
Sbjct: 1887 EAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVI 1946

Query: 2154 LKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRG 2213
               Q  +AE++A  +  +S    G+ LLA+SH  A E+S++L  L+   ++  +    + 
Sbjct: 1947 KNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKM 2006

Query: 2214 QELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
              L+     L F +   +AEAW+  +E  +   +LG  ++    L +R   F+
Sbjct: 2007 DWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQ 2059



 Score =  295 bits (756), Expect = 4e-79
 Identities = 402/1834 (21%), Positives = 756/1834 (41%), Gaps = 137/1834 (7%)

Query: 1281 LQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
            +++++   +EL+QW+E+          A+  SG + N LQ+   +   E     T +   
Sbjct: 307  VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQ-NQLQSFNSYRTVEKPPKFTEKG-- 363

Query: 1336 ALQQVGRELLSRRPCGQEDIQTRLQG-----LRSKWEALNRKMTERGDELQQAGQQEQLL 1390
             L+ +   + S+     + + T  +G     +   WE L +   ER   L+    +++ L
Sbjct: 364  NLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKL 423

Query: 1391 RQLQDAKEQ--------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
             QL    ++        L + +  +     G +L + +   ++H+ +E++    + ++ A
Sbjct: 424  EQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQA 483

Query: 1443 LASMAHGMAASP----AILEETQKHLRRL-ELLQGHLAIRGLQLQASVELHQFCHLSNME 1497
            + ++A  +AA        +   Q ++ RL + L+  +A R  +L  ++EL +        
Sbjct: 484  VDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL 543

Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557
            + W+ E             L G + L + H+ ++ ++     +V+ V +S       G  
Sbjct: 544  MDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKE 603

Query: 1558 ----QAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPL 1613
                  Q + E+  +LE  +  L     AR   L+++    ++  +V E E WV E++ L
Sbjct: 604  YRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHL 663

Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP--EQQRVVQE 1671
            ++S D GRD    LRL+NKH AL+ E++     ++   +  Q L     P   Q      
Sbjct: 664  LASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA 723

Query: 1672 RLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHA 1731
             L+ Q   L+ LA  R + L     L++F  +A D++ WL    +     E LG D    
Sbjct: 724  ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE-LGHDEFST 782

Query: 1732 LHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
              L  +    + ++      + A R  A +L     S  P V+ R   L+  + EL    
Sbjct: 783  QALARQHRALEEEIRSHRPTLDALREQAAALPPT-LSRTPEVQGRVPTLERHYEEL---- 837

Query: 1792 QAR-GHALRDTETTLRVHRDLLEVLT---QVQEKATSLPNNVA--RDLCGLEAQLRSHQG 1845
            QAR G   R  E  L ++  L E       V+EK   L N +A    L  LE   +  + 
Sbjct: 838  QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL-NGLALPERLEDLEVVQQRFET 896

Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
            LE E+     Q+  + + A ++ K  P P    +   Q+ +   W   +R  + ++A L 
Sbjct: 897  LEPEMNTLAAQITAVNDIAEQLLKANP-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALT 955

Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR-EKLW 1964
             A  +  +     +  +W   +R+  +V ES+Q   +    + A Q   A  E   E + 
Sbjct: 956  SALSIQNYHLECTETQAW---MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIA 1012

Query: 1965 QQATQLGQQA-LLAAGTPTKEV--QEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
             +  +L ++A  LAAG P + V     LR +Q   + +  T  R++E L   ++ Q FLR
Sbjct: 1013 ARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLR 1072

Query: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR 2081
                 +  L   + ++ +    +++ E E L+ +H      L  + ++  +   RL+ L 
Sbjct: 1073 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAA----LRGEVERAQSEYSRLRALG 1128

Query: 2082 RPRVRDRL-PILLQRRMRVKELA----------ESRGHALHASLLMASFTQAATQAEDWI 2130
                RD+  P  L  R R++ L           ESR   L  +     F + A QAE  +
Sbjct: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188

Query: 2131 QAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE 2190
             +    L     PG L+     + K + F + + A+ E +  + + G  L+++ +  A +
Sbjct: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248

Query: 2191 VSQRLQGL-RKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
            + ++   + R+H ++   A    G+ L D R    FLQ     + WI EK   +   D+ 
Sbjct: 1249 IREKADSIERRHKKNQDAAQQFLGR-LRDNREQQHFLQDCHELKLWIDEK--MLTAQDVS 1305

Query: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309
             D      L  + ++ +   A        +  +     +L    PE   ++ ++   L+ 
Sbjct: 1306 YD--EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHR 1363

Query: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369
            RW           + L  A    + ++    +   ++  +A + + D GKDL SV  LL+
Sbjct: 1364 RWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLK 1423

Query: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
            K + LE E+   + +VE+++ +   L Q   + A  +    + V E +  L    ++R  
Sbjct: 1424 KQQMLEWEMAVREKEVEAIQAQAKALAQED-QGAGEVERTSRAVEEKFRALCQPMRERCR 1482

Query: 2430 ALDALHQAQKLQAMLQ-ELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWT 2488
             L A  +  +    ++ E+L   +RL            P   + +++++Q  + E+    
Sbjct: 1483 RLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP-SVQLLMKKNQTLQKEIQGHE 1541

Query: 2489 DSISLARSTGQQL-LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
              I+  R   + L   A  P  ++++++   L  EL  L G       +L+ AL  Q F 
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE-LRGK------RLEDALRAQQFY 1594

Query: 2548 SSVEKMERWLCSKE-DSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARG 2606
                + E W+  +E   +  E   D L+    +  KH++LE  L   A  I  L A+++ 
Sbjct: 1595 RDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK-KHQVLEQALADYAQTIHQLAASSQD 1653

Query: 2607 LHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK 2666
            +    HPE+     R   +      L   AG RR RL+E  +L    ++  ++  W++E+
Sbjct: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713

Query: 2667 NLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQRE-GQRLLQGGHPASEAIQ 2724
             +VA    L  D   +     K + F  +      ++ +        L+ GGH A   + 
Sbjct: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773

Query: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQAL 2784
            E  + L   W +L +    +   L  A E  R      +            R     Q L
Sbjct: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQ---------ALARVQHKQQQL 1824

Query: 2785 PGVGELLGTQRELEAAVDKKARQA------EALLGQAQAFVREGHCL--------AQDVE 2830
            P      GT R+L AA   + R        +AL  Q Q    +GH L        A+++ 
Sbjct: 1825 PD-----GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879

Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
               + + + +  L+     RR  L   +   +FF+   E M W+ E      AQ+  + +
Sbjct: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939

Query: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
            S+   + +  Q +++E+ +        +  G +L+   H+AA E++ ++ QL+       
Sbjct: 1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQ------- 1992

Query: 2951 AEAARRRLLLQQAQEAQQFLTELLE----------AGSWLAERGHVLDSEDMGHSAEATQ 3000
               ARR+   ++ QE   +L  +LE          A +WL  +  ++ S ++G + +  +
Sbjct: 1993 ---ARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVE 2049

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRK 3034
            +L++R EA ++   A+  R   L++  AL E  K
Sbjct: 2050 SLIKRHEAFQKSAVAWEERFCALEKLTALEEREK 2083



 Score =  269 bits (687), Expect = 4e-71
 Identities = 317/1399 (22%), Positives = 573/1399 (40%), Gaps = 84/1399 (6%)

Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL---RDKLKPLLKH 2156
            K + +   HA+ A  L+  +   A++   WI+     L +      L   +++L+    +
Sbjct: 291  KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350

Query: 2157 QAFE-----AEVQAHEEVMTSVAKKGEALLAQSH-PRAGEVSQRLQGLRKHWEDLRQA-- 2208
            +  E      E    E ++ ++  K  A   + + PR G +   +  + K WE L +A  
Sbjct: 351  RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRL---ISDINKAWERLEKAEH 407

Query: 2209 ---MALRGQELEDRRNFLE-----FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRR 2260
               +ALR + +  R+  LE     F ++  + E W+ E +  ++  + G +L     +  
Sbjct: 408  ERELALRTELI--RQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLEL---AAVEA 462

Query: 2261 RLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLR 2320
             +R+              ++++  ++ +L      ++K I  R+  +   W      +  
Sbjct: 463  AVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAA 522

Query: 2321 YQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHP 2380
             +++L   LE+  + ++L  +   ++E +  +Q+ D G+ L  V+ LL+ HE +E ++  
Sbjct: 523  RRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAV 582

Query: 2381 IQAQVESLEREVGRLC-----------QRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
               +V ++     R C           Q   E    L    + + E     R+R ++ R 
Sbjct: 583  QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642

Query: 2430 ALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
                L +  + +A ++E     Q L A  DT    R    A R+L +H   + E+     
Sbjct: 643  LWRFLWEVGEAEAWVRE----QQHLLASADTG---RDLTGALRLLNKHTALRGEMSGRLG 695

Query: 2490 SISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSS 2549
             + L    GQQL+  GHP +S      A L+ +   LE   +E   +L QA  L  F + 
Sbjct: 696  PLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQAD 755

Query: 2550 VEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ 2609
               ME WL      ++S  L       + L  +H+ LE ++      + AL   A  L  
Sbjct: 756  ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815

Query: 2610 --GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
                 PE Q   GR   +    E L  +AG R   LE    L   L ++     W+ EK 
Sbjct: 816  TLSRTPEVQ---GRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKE 872

Query: 2667 ---NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
               N +AL E L D   L    Q+ +  + E++    Q   +    ++LL+   P  + I
Sbjct: 873  QWLNGLALPERLED---LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRI 929

Query: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWL-EPIEVELRAPTVGQ 2782
                E+L   W + +  +  K A L  A           E + W+ E  +V      +G 
Sbjct: 930  VNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGN 989

Query: 2783 ALPGV----GELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
             L GV     +L GT+R+LEA     A +   L  +A A        A  +  + R +  
Sbjct: 990  DLAGVLALQRKLAGTERDLEAI----AARVGELTREANALAAGHPAQAVAINARLREVQT 1045

Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             ++ LR  ++ R  +L     L  F R  D+  AW+       A+++   +L     L  
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105

Query: 2899 QHQNL--ESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARR 2956
            QH  L  E E +  E      LG      QA       +  R++ L      L      R
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF-LRQRLEALGTGWEELGRMWESR 1164

Query: 2957 RLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
            +  L QA   Q FL +  +A   L+ + +VL   +M  + +A  A +++LE     ++A 
Sbjct: 1165 QGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDAN 1224

Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
              RI  L +    L S  N  + K+  +  ++   H +    A+     L++  +     
Sbjct: 1225 GERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL 1284

Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGT 3136
            ++   L  W+  K  TA+   Y  +   +    +K  AF  E+ +  +  +  + K    
Sbjct: 1285 QDCHELKLWIDEKMLTAQDVSY-DEARNLHTKWQKHQAFMAEL-AANKDWLDKVDKEGRE 1342

Query: 3137 LERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK 3196
            L    P     +  +   +   W+ L+   +A+  +L  A+    F Q+   L+  ++  
Sbjct: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402

Query: 3197 TALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK 3256
             A +  +D G  L+SV  L ++ + LE E+   EKEV  +Q +A  L Q    A G + +
Sbjct: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA-GEVER 1461

Query: 3257 ----VQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVA 3312
                V+E +  L    +ER + L  + + H F    ++ + W  ER  +ASS E  +D+ 
Sbjct: 1462 TSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP 1521

Query: 3313 GAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRL-QELE 3371
              + L+ +++ L +EI+    +  DLR+  + L   +     E+ E LQE+  RL  ELE
Sbjct: 1522 SVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL--GAAAAGPELAE-LQEMWKRLGHELE 1578

Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
                LR +R  ++   Q+  +   +AEAW+   E  ++  +        +  + +HQ LE
Sbjct: 1579 ----LRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLE 1634

Query: 3432 KLLAAQEEKFAQMQKTEME 3450
            + LA   +   Q+  +  +
Sbjct: 1635 QALADYAQTIHQLAASSQD 1653



 Score =  241 bits (615), Expect = 1e-62
 Identities = 377/1841 (20%), Positives = 706/1841 (38%), Gaps = 131/1841 (7%)

Query: 706  LQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAE 765
            ++   LV +Y + A+E   W+ +   +L         +  +  L+       V +     
Sbjct: 301  MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKP---- 356

Query: 766  LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDP 825
              +  E+G   +    LFT+ S L    + +  P    E         AW+    AE + 
Sbjct: 357  -PKFTEKG---NLEVLLFTIQSKLRANNQKVYTP---REGRLISDINKAWERLEKAEHER 409

Query: 826  DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ 885
            +    T L                  +R+ +LE+  A F   ++  E  L   ++ V   
Sbjct: 410  ELALRTEL------------------IRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451

Query: 886  RVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQ 945
                +   +E    K+E   T +    G    V + A +L      +  +I  +Q  +++
Sbjct: 452  NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511

Query: 946  RWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG----SSEDTCH 1001
             W  L  +   +  +L  ++E+    Q+       + ++  +L++   G      ED   
Sbjct: 512  LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571

Query: 1002 ALQLAQKKTLVLERRVHFLQSVVVKVEEPGY----AESQPLQGQVETLQGLLKQVQEQVA 1057
              +L +    V   RV  + +  ++   PG      + Q +  +V  L+   + + E  A
Sbjct: 572  LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631

Query: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIH 1117
             R  R  E++    FL E  +   W    Q  L S +   D+  A RLL +H  L  E+ 
Sbjct: 632  ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691

Query: 1118 LWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177
                 L+    Q Q + A   P + +       L  Q + L+ L E+R Q L +   L +
Sbjct: 692  GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751

Query: 1178 FGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGE 1237
            F  + +   A   +    +    LG D     +L +QHR     + +  P  +ALR    
Sbjct: 752  FQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAA 811

Query: 1238 KL--VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM 1295
             L    S+ P    V+ ++ +++  +  LQ R+ +R R L A+L L     +      W+
Sbjct: 812  ALPPTLSRTP---EVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWV 868

Query: 1296 EEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED 1354
            EEK           R   L+ + +R E  E E+      + A+  +  +LL   P G++ 
Sbjct: 869  EEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDR 928

Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE-TG 1413
            I    + L  +W+   R    +   L  A   +    +  + +  + +    ++S++  G
Sbjct: 929  IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988

Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL----E 1468
             DL     LQ++    E +   +AA++  L   A+ +AA  PA        LR +    E
Sbjct: 989  NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048

Query: 1469 LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHK 1528
             L+  +  R   L  +  L  F    +   +W+       +       L  A++L  +H 
Sbjct: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108

Query: 1529 ELQVEVKAHQGQVQRVLSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCL 1587
             L+ EV+  Q +  R+ + G  +      PQ   + ++ + L   W EL R  E+R   L
Sbjct: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168

Query: 1588 QQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSM 1647
             QA  FQ +  D  + EG       ++SS++Y          +    A  ++L  + S+M
Sbjct: 1169 AQAHGFQGFLRDARQAEG-------VLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTM 1221

Query: 1648 EELDQTAQTL--TGPEVPEQQRVVQERLREQLRAL-------QELAATRDRELEGTLRLH 1698
            +   +    L   G ++  +  +  +++RE+  ++       Q+ A      L       
Sbjct: 1222 DANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ 1281

Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
             FL++  +L+ W+  +   A   + +  D    LH  TK+ K  HQ  M    +AA +  
Sbjct: 1282 HFLQDCHELKLWIDEKMLTA---QDVSYDEARNLH--TKWQK--HQAFMA--ELAANKDW 1332

Query: 1759 AESLLERGH-------SAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
             + + + G            +V ++ +DL   W EL   TQA+  +L D        +  
Sbjct: 1333 LDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSC 1392

Query: 1812 LEVLTQVQEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKL 1870
              + + ++     L  ++  +DL  +   L+  Q LE E+   E++++ +   A  + + 
Sbjct: 1393 CALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQE 1452

Query: 1871 CPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQD 1930
              G  A  V++  +AV + +  L + M +R  +L+ +R   +F   V D   W       
Sbjct: 1453 DQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPM 1510

Query: 1931 LQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELR 1990
                E  ++  S  L +  +Q L+ E++  E       +  +    AA  P      EL 
Sbjct: 1511 ASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGP------ELA 1564

Query: 1991 ALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVE 2050
             LQ+   ++      + +RL+   + Q F R+    E  +  QE+ +            +
Sbjct: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ 1624

Query: 2051 QLIRKHEVFLKVLT--AQDKKE-AALRERLKTLRRP---RVRDRLPILLQRRMRVKELAE 2104
              ++KH+V  + L   AQ   + AA  + +     P   R+  R   + +    +KELA 
Sbjct: 1625 AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAG 1684

Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQ-----AWAQQLKEPVPPGD-LRDKLKPLLKHQA 2158
             R   L   L +    +     E WIQ     A + +L +       LRDK +   +  +
Sbjct: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744

Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
                    +E + S       L+A  H     V++    L + W DL + +  RGQ L  
Sbjct: 1745 -----TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799

Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
                  FL     A A +Q K+ ++  G  G+DL     L+RR   +  +    +     
Sbjct: 1800 AYELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAYEHDIQALS---PQ 1855

Query: 2279 IRSISDLSLQL-KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRE 2337
            ++ + D   +L K    ++ + I +    +   WA   G+    +Q L    +     + 
Sbjct: 1856 VQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1915

Query: 2338 LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQ 2397
            +  +   + E    + A +  +D+ S   +++  + ++ E+     +  S       L  
Sbjct: 1916 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLA 1975

Query: 2398 RSPEAAH-------GLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML--QELL 2448
            RS  AA         L+ R+QE AE W +     Q   E L     A   +A L  QE L
Sbjct: 1976 RSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPL 2035

Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
            V +  L   +D         E   +++ H+  +    +W +
Sbjct: 2036 VRSAELGCTVD---------EVESLIKRHEAFQKSAVAWEE 2067



 Score =  241 bits (615), Expect = 1e-62
 Identities = 273/1311 (20%), Positives = 524/1311 (39%), Gaps = 86/1311 (6%)

Query: 406  FLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHS 465
            ++++ EQ L+   A P  L  +E   QR   LE  +     +  A+ +IA+ L +     
Sbjct: 867  WVEEKEQWLN-GLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPG 925

Query: 466  WADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARST- 524
               +   QE++  RWQ+  +   G++  +    ++ +   E       + E  +   ST 
Sbjct: 926  KDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985

Query: 525  ACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
              G  LA V+ L ++    E  + A  A V  L ++   L +        + A+ R +  
Sbjct: 986  GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045

Query: 585  LQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
              + L A +R R   L +  +  +FLR+ ++ +AWL      V +      L +    L 
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105

Query: 645  KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-----ERAEAVQGGWQLLQTRV 699
            +H AL  EV R Q+    L   G +++      Q DP      +R EA+  GW+ L    
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFLRQRLEALGTGWEELGRMW 1161

Query: 700  VGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVL 759
              R  RL  A     +  DA +A   L  +   L                  H  +   L
Sbjct: 1162 ESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-----------------HTEMPGTL 1204

Query: 760  RAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMAL 819
            +A  A +++LE+      A          L   G  L + G                   
Sbjct: 1205 QAADAAIKKLEDFMSTMDANGERI---HGLLEAGRQLVSEG------------------- 1242

Query: 820  PAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEK 879
                  +   + I +  D + + ++  +  AQ    RL +      F   C EL+LW+++
Sbjct: 1243 ------NIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE 1296

Query: 880  QTVLLQRVQ-PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQR 938
            + +  Q V   +A  L     K++ F+  LA  K    +V     +L    P     +  
Sbjct: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356

Query: 939  QQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSED 998
            +  +L +RW +LE   + KA  L  +     F Q C   +  L  +  QL +   G    
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416

Query: 999  TCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVE----TLQGLLKQVQE 1054
            + + L L +++ L  E  V   +   ++ +    A+     G+VE     ++   + + +
Sbjct: 1417 SVNIL-LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQ 1475

Query: 1055 QVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLE 1114
             + +R RR   ++ +  F ++ +  +LW         S E   D+ S Q L++++Q L +
Sbjct: 1476 PMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQK 1535

Query: 1115 EIHLWQERLQQLDAQSQPM-AALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL 1173
            EI   + R+  L  + + + AA   P+  E+    + LG +        E R + L++ L
Sbjct: 1536 EIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE-------LELRGKRLEDAL 1588

Query: 1174 ELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
              Q+F R+     A     +  +      +D   A + +++H+   + L+        L 
Sbjct: 1589 RAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLA 1648

Query: 1234 AHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
            A  + ++  +HP +  +  +   +   +  L+  + +RR +L   L+L + ++++ +L Q
Sbjct: 1649 ASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQ 1708

Query: 1294 WMEEKGLMAAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCG 1351
            W++E+ ++AA    G     +  L  K  E +       +  V++   +   L++     
Sbjct: 1709 WIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAA 1768

Query: 1352 QEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE 1411
            +  +      L   W  L   +  RG  L  A + ++ L   + A  +++  +  L    
Sbjct: 1769 RATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG- 1827

Query: 1412 TGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRLE- 1468
            TG+DL +++ LQ+RH   E + + L+ ++  +    H +  + A    EE  +H++ +  
Sbjct: 1828 TGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAE 1887

Query: 1469 ---LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHR 1525
                LQG  A R   L  + +  +F       + W+ E             ++ A  + +
Sbjct: 1888 AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIK 1947

Query: 1526 KHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQ 1585
              + ++ E++A   +    +  G+ L A  H  A+ I E+  +L+    E     + +  
Sbjct: 1948 NQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMD 2007

Query: 1586 CLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWS 1645
             LQ  +    +  D    E W+  + PLV S + G        LI +H+A Q+  A+ W 
Sbjct: 2008 WLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS-AVAW- 2065

Query: 1646 SMEELDQTAQTLTGPEVPEQQRV---VQERLREQLRALQELAATRDRELEG 1693
              EE     + LT  E  E++R     +E  R+Q  A +  A+    +L G
Sbjct: 2066 --EERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score =  930 bits (2404), Expect = 0.0
 Identities = 616/2131 (28%), Positives = 1062/2131 (49%), Gaps = 89/2131 (4%)

Query: 8    GHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEAL 67
            G  ++LQ     +Q+KTFTKW+N+     +   +I +LYT+L DG  L++LLE++SGE L
Sbjct: 30   GRFKQLQDEREAVQKKTFTKWVNS--HLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 87

Query: 68   PPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRFQIS 126
            P P++GR+R+H LEN  +AL FL+  +V +  +G  +IVDG+  L LGLIW IILRFQI 
Sbjct: 88   PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 147

Query: 127  HISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRP 186
             IS++ E+   +    S K+ALL+WCQ KTA Y NVNI +F+ SW DG+ FNALIH HRP
Sbjct: 148  DISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRP 204

Query: 187  DLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYC 246
            DL+D+  L+     +NL  AF +AEQ LG+ +LLDPED++   PDE+SI+TYV  YYHY 
Sbjct: 205  DLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYF 264

Query: 247  SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
            S++       +R+ K+L    ETE +  +YE L +DLL WI +  + L  R F +SL  +
Sbjct: 265  SKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGV 324

Query: 307  RQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366
            +Q L AF  +RT EKPP+  ++G  E LLF +Q+ ++A N++ ++P EG  ++++++ W 
Sbjct: 325  QQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWE 384

Query: 367  GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
             LE AE  R  AL+  L++ ++LE LARRF  KAA+RE++L + ++++ Q       L  
Sbjct: 385  RLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPA 443

Query: 427  VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQH 486
            VEAA ++   +E  I   E R QA+  +A  L  E YH    +  R++ V   W+ LL+ 
Sbjct: 444  VEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLEL 503

Query: 487  LQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQ 546
            L+ +R+++     +  + QE+      ++E++    S   G+ L  V +LLQ+H L+EA 
Sbjct: 504  LRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEAD 563

Query: 547  VSAHGAHVSHL---AQQTA-ELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQ 602
            +      V  +   AQ+ A + +       +V++ +   +    Q L  L   RRA LE+
Sbjct: 564  IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEE 623

Query: 603  TLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVD 662
            + +  +F     EEE W++E  + + +   G+DL+ +   L KH+A E E+         
Sbjct: 624  SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQ 683

Query: 663  LVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEA 722
             ++ G D+ A          ER   ++  W  L+     R  RL+ A L+ Q+ ADA + 
Sbjct: 684  AIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDI 743

Query: 723  ASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASL 782
             +W+ +    +  +  G D+ + ++L+++H  +   +  +   L  L EQ  A       
Sbjct: 744  DAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL------ 797

Query: 783  FTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQD 842
                     P E   +P      S                                + + 
Sbjct: 798  ---------PQEHAESPDVRGRLS-------------------------------GIEER 817

Query: 843  YESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLK 900
            Y+ +  L +LR+  L++ +AL+   S     +LW++++   L  +Q   + + LEV+Q +
Sbjct: 818  YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877

Query: 901  YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960
            +E+    +       A V+  A QL      +  +I+ QQ++L+ RW Q   L   K   
Sbjct: 878  FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937

Query: 961  LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------LVLE 1014
            L  ++ + ++  EC  T+  +R+    +E+ Q     D    + L +K T      + +E
Sbjct: 938  LLSALSIQNYHLECNETKSWIREKTKVIESTQ-DLGNDLAGVMALQRKLTGMERDLVAIE 996

Query: 1015 RRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQ 1074
             ++  LQ    K+E     ++Q +  ++  +  + ++++  +  R     E    Q FL+
Sbjct: 997  AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLR 1056

Query: 1075 ESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
            +      W    Q  + S+++   +  A++LL +H+++  EI  ++E  Q++    + M 
Sbjct: 1057 DLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MV 1115

Query: 1135 ALDCPDSQE--VPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH 1192
                 D+Q   +   L+ L     EL  +WE RQ  L +    Q+F R+     A   N 
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1175

Query: 1193 QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVRE 1252
            +  L    +   +  A + +++  +F   +     +  A+   G +LV   +  +  ++E
Sbjct: 1176 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1235

Query: 1253 QLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRN 1312
            ++ SI  +  + +  + +   +L  +  LQ++ QD  EL  W+ EK L A        RN
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN 1295

Query: 1313 ILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRK 1372
            +     +H+A  +EL + +  ++ +++ G +L+S +P  +  ++ +L GL   WE L   
Sbjct: 1296 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLEST 1355

Query: 1373 MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESE 1432
               +   L  A + E   +   D  + L  LE  +QS + G+DL S   L K+ Q LE++
Sbjct: 1356 TQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQ 1415

Query: 1433 SRTLAAKMAALASMAHGMAASPAILEETQK-----HLRRLELLQGHLAIRGLQLQASVEL 1487
                  ++  L S A  ++      +E          + +ELL+  L  R   L AS E+
Sbjct: 1416 MEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLE-PLNERKHNLLASKEI 1474

Query: 1488 HQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSS 1547
            HQF      E+ WV E MP  + T +   L   Q L +K++ LQ E++ HQ ++  +   
Sbjct: 1475 HQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534

Query: 1548 GRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
             +++   S    A+ I ++  +L+  W  L    E R + L++A   QQY+ D +E E W
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1594

Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
            + E+   + S +  +DE + + ++ KHQ L++ +  Y  ++ +L +T++ L     PE +
Sbjct: 1595 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE 1654

Query: 1667 RVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESL 1724
            R+   Q ++ +    L++LA  R  +L+   RL +  RE +DL+ W+A +++   G   L
Sbjct: 1655 RISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA-EREVVAGSHEL 1713

Query: 1725 GEDPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
            G+D EH   L  +F +F      +G +RV     LA+ L+  GHS    + + +  L  A
Sbjct: 1714 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1773

Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
            W++L EL   R   L  +    + + D  E+  ++Q+K   LP  + RD   +E   R H
Sbjct: 1774 WADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMH 1833

Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQ 1903
               E ++     Q+++L E A R+Q    G +A  +Q+R+  V +AW  L    E RR +
Sbjct: 1834 TTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVR 1893

Query: 1904 LERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKL 1963
            L       RF + VRD   W   V + ++ +E  ++ SS  L ++ HQ ++AE++AR   
Sbjct: 1894 LVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDS 1953

Query: 1964 WQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLREC 2023
            +    +LG+  L      ++E++E+L  L ++R ++   W  + E L+   +   F R+ 
Sbjct: 1954 FTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDA 2013

Query: 2024 GRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP 2083
               E  L  QE  L +  +G SV+EVE+LI++HE F K     D++ +AL ERL TL   
Sbjct: 2014 SVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTLELL 2072

Query: 2084 RV--------RDRLPILLQRRMRVKELAESR 2106
             V        R R P   +   +V E AES+
Sbjct: 2073 EVRRQQEEEERKRRPPSPEPSTKVSEEAESQ 2103



 Score =  537 bits (1384), Expect = e-152
 Identities = 423/1727 (24%), Positives = 797/1727 (46%), Gaps = 72/1727 (4%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW  L +    R  ALR+      + ++ LE L +  ++  ++             
Sbjct: 378  DINKAWERLEKAEHERELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 433

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
             +N   DL  +EA  + H+ +E ++   E ++Q ++  A  ++        H +++   R
Sbjct: 434  QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELE----AENYHDIKRITAR 489

Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
            +  V + W  L   +  RR +LE    L +    +     W   ++  +  ++  +    
Sbjct: 490  KDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLG 549

Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE-----VQEELRALQDQRD 1997
                L  H  + A++  + +   +      Q     G   K      +++ +  ++    
Sbjct: 550  VEDLLQKHTLVEADIGIQAER-VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 608

Query: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
            ++ Q  A ++ RL+  ++   F  E    E  +  +E  L +   G  +  V +L+ KH 
Sbjct: 609  ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 668

Query: 2058 VFLKVLTAQDKK-EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRGHALH 2111
             F   ++ +    E A++E    +        ++R+R+  + ++   +++L+  R   L 
Sbjct: 669  AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 728

Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL-RDKLKP---LLKHQAFEAEVQAHE 2167
             + L+  F   A    D I AW   + + V   D+  D+      + KH+    E+  + 
Sbjct: 729  EASLLHQFQADA----DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 784

Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQ 2227
              + ++ ++  AL  Q H  + +V  RL G+ + ++++ +   LR Q L+D     +   
Sbjct: 785  PTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 843

Query: 2228 RVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSL 2287
              D  E WI EKE  +N   + + LE    ++ R               A +  I+   +
Sbjct: 844  EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLM 903

Query: 2288 QLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQE 2347
               +   +E+K    ++ +LN RW+ F   + R +  L  AL I     E +     I+E
Sbjct: 904  HSGHPSEKEIKA---QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIRE 960

Query: 2348 KEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
            K  +I++  D G DL  V  L RK   +ER++  I+A++  L++E  +L    P+ A  +
Sbjct: 961  KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020

Query: 2407 RHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPA 2463
              R  E+++ W ++++   K REA  +L +A KLQ  L++L        R +  + +   
Sbjct: 1021 LSRLAEISDVWEEMKTTL-KNREA--SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1077

Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQ 2521
            P +  EA ++L +H+  K E+D++ +     R  G+ ++T G   +    +RQ L  L+ 
Sbjct: 1078 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRLQALDT 1136

Query: 2522 ELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW 2581
              + L   W+  Q  L Q+   Q FL   ++ E +L ++E  LA   +   L   E  + 
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIK 1196

Query: 2582 KHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRH 2641
            K +     ++    KI+A+  T R L   G+  +     +  ++  R       A     
Sbjct: 1197 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1256

Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
            RL++ R LQ FLQD QE++ W+ EK L A +    +   L ++  K Q F AEL ++   
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1316

Query: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
              ++++EG +L+         ++E+L  L  +W  L+  +Q K  +L  A +A    +S 
Sbjct: 1317 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSC 1376

Query: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
             +L+ WL  +E ++++   G+ L  V  LL  Q+ LE  ++ + ++ E L  QAQA  +E
Sbjct: 1377 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1436

Query: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLA 2881
            G     +V+ +   +  +F  L EPL ER+  L A   + +F RD ++E+ WV E++PLA
Sbjct: 1437 GKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLA 1495

Query: 2882 AAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLV-QAGHFAAHEVAARVQ 2940
             + D+G +L  V+ L +++Q L+ E+  H+     +      +V  +   +A  +  R+ 
Sbjct: 1496 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1555

Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
             L++    L  E  +R   L++A  AQQ+  +  EA +W++E+   + SE+     ++  
Sbjct: 1556 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1615

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            ++L++ +  ++ +E ++  + +L +T+  L +  +PES ++  +   V + +A L   AE
Sbjct: 1616 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1675

Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
             R   L E+ +L QL RE   L+ W+  +   A S + GQD E V +L+E+F  F ++  
Sbjct: 1676 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1735

Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
            ++GQ +V  +  LA  L          I   +  +  AW  L + I  RT+ LAA++E+H
Sbjct: 1736 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1795

Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
             F   A E+ GR+Q+K   +  E+ G   ++V TLQ+ H   E +++A+  +V +LQ +A
Sbjct: 1796 KFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA 1854

Query: 3241 CRLGQLHPAAPGGLA--------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELL 3292
             R   L  A  G  A        +V EAW +L    + R   L        F    ++L+
Sbjct: 1855 AR---LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM 1911

Query: 3293 AWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFM 3352
             W ++      ++E   DV+  E L+  H+ +  EI           + G+ L+   H+ 
Sbjct: 1912 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYA 1971

Query: 3353 SAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPD 3412
            S E+ E L +L  + +E+ + W  RW+       + +  +    AEAWL   E  L   +
Sbjct: 1972 SEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2031

Query: 3413 YGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQE 3459
             G SV +VE L+ RH+  EK  A  +E+F+ +++    + L ++ Q+
Sbjct: 2032 IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQ 2078



 Score =  435 bits (1119), Expect = e-121
 Identities = 369/1699 (21%), Positives = 748/1699 (44%), Gaps = 62/1699 (3%)

Query: 1254 LQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHE 1305
            +  I   W RL+    +R   L   L  QE  + +A            W+ E   + + +
Sbjct: 376  ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 435

Query: 1306 PSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
              G     ++   K+HEA E+++ A    V+A+  V REL +      + I  R   +  
Sbjct: 436  NFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR 495

Query: 1365 KWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK 1424
             WE L   +  R   L+     +++ +++    + +++++  + S + G+ L   + L +
Sbjct: 496  LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQ 555

Query: 1425 RHQQLESESRTLAAKMAALASMAHGMAAS--------PAILEETQKHLRRL--ELLQGHL 1474
            +H  +E++    A ++  + + A   A          P ++ +   H+     EL Q   
Sbjct: 556  KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ-LA 614

Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
            A R  +L+ S  L +F      E  W+ E     S   Y + L     L  KH+  + E+
Sbjct: 615  AERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEM 674

Query: 1535 KAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQ 1594
                G  ++ +  G  + A  H  ++ I E+   +   WA LE+    R + L++A    
Sbjct: 675  SGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 734

Query: 1595 QYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
            Q+  D  +++ W+ +   +VSS D G DE +T  L+ KH+ + EE+A Y  +++ L + A
Sbjct: 735  QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 794

Query: 1655 QTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
              L       P+V  +   ++ER +E    + EL   R + L+ TL L++   EA+  + 
Sbjct: 795  SALPQEHAESPDVRGRLSGIEERYKE----VAELTRLRKQALQDTLALYKMFSEADACEL 850

Query: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
            W+  +K+       + E  E    +  +F   + ++   + RVA    +A  L+  GH +
Sbjct: 851  WI-DEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS 909

Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-- 1827
               ++ +Q  L T WS+  EL   +  AL    +    H +  E  + ++EK   + +  
Sbjct: 910  EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 969

Query: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
            ++  DL G+ A  R   G+ER+LV  E +L +L + A +++   P  QA A+  R   ++
Sbjct: 970  DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEIS 1028

Query: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
              W  ++  ++ R A L  A  L +F   + D+ SW +R +  +  E+     +     L
Sbjct: 1029 DVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1088

Query: 1948 SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWA 2004
            + H+ ++ E++  E+ +Q+   +G+  ++  G    +   +++ L+AL    +++++ W 
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE 1146

Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
             +Q  L      Q FLR+  + E  L  QE  L  + + +++E  E  I+K E F+  + 
Sbjct: 1147 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMD 1206

Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
            A ++K  A+ E  + L         R+++++  +  R  + +E A      L  +  +  
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1266

Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
            F Q   +   WI        + +   + R+     LKHQAF AE+ +++E +  + K+G 
Sbjct: 1267 FLQDCQELSLWINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM 1325

Query: 2179 ALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQE 2238
             L+++       V ++L GL K WE L      + Q L D      F Q     + W+  
Sbjct: 1326 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHG 1385

Query: 2239 KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLK--NRDPEE 2296
             E ++   D G+DL     L ++ +            +   + I +L  Q +  +++ + 
Sbjct: 1386 LESQIQSDDYGKDLTSVNILLKKQQMLENQM------EVRKKEIEELQSQAQALSQEGKS 1439

Query: 2297 VKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD 2356
               +  +R  +  ++      L   +  L  + EIH  +R++++    + E+  L  + D
Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499

Query: 2357 CGKDLESVQRLLRKHEELEREVHPIQAQVESL-EREVGRLCQRSPEAAHGLRHRQQEVAE 2415
             G +L++VQ L++K++ L++E+   Q +++ + ER    +   S  +A  +R R  ++ +
Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1559

Query: 2416 SWWQLRSRAQKRREALDALHQAQK--LQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRM 2473
             W  L    +KR   L+  H+AQ+    A   E  +S Q L   M +    +    A  M
Sbjct: 1560 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL--YMMSEEKAKDEQSAVSM 1617

Query: 2474 LEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH 2533
            L++HQ  +  ++ + +++     T + L+   HP S  I    + +++  + L+   +E 
Sbjct: 1618 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1677

Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL-EV 2592
            + +L +   L      V+ +E+W+  +E    S  L      +  L  + +    D   +
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737

Query: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
               ++  +   A  L   GH +A +       +      L     TR   L    +L  F
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797

Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRL 2712
              D++E+   +++K+    EE   D   +    +    F+ ++ A   Q ++LQ +  R 
Sbjct: 1798 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR- 1856

Query: 2713 LQGGHPASEA--IQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
            LQ  +   +A  IQ+R  E+   W  L D  + +  +L    +  R    + +L  W+E 
Sbjct: 1857 LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1916

Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE 2830
            +  ++ A    + +  V  L+   + ++A +D +       +   ++ +   H  +++++
Sbjct: 1917 VIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1976

Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
            E+  +L ++ K + +  ++R   L     + +F RDA    AW+  + P  ++++ GQS+
Sbjct: 1977 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV 2036

Query: 2891 SAVRHLQEQHQNLESEMSS 2909
              V  L ++H+  E   ++
Sbjct: 2037 DEVEKLIKRHEAFEKSAAT 2055



 Score =  392 bits (1006), Expect = e-108
 Identities = 381/1789 (21%), Positives = 759/1789 (42%), Gaps = 75/1789 (4%)

Query: 868  SSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL-- 925
            S   +L  W+E QT+++   +  A++L  +Q + + F T   V K        + E L  
Sbjct: 296  SLASDLLEWIE-QTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 354

Query: 926  --RQRYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECG 975
              + +   N+ ++   +E     ++++ W +LE  + E+ + L + +   E    L    
Sbjct: 355  TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRF 414

Query: 976  PTQVQLRDVLLQLEALQPGSSEDT----CHALQLAQKKTLVLE-------RRVHFLQSVV 1024
              +  +R+  L     Q   S+D       A++ A KK   +E        RV  + +V 
Sbjct: 415  DRKAAMRETWLSEN--QRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVA 472

Query: 1025 VKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAE 1084
             ++E   Y + + +  + + +  L + + E +  R +R       Q   QE   ++ W +
Sbjct: 473  RELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 532

Query: 1085 SVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAA-----LDCP 1139
             ++  + S++    +   + LL++H  +  +I +  ER++ ++A +Q  A        C 
Sbjct: 533  EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC- 591

Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1199
            D Q + + +  +    QEL  L  +R+  L+E   L KF  E+          +  L  D
Sbjct: 592  DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD 651

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
            + G+D+   + LL +HR F   +S      E     GE ++  +H  +  +RE++  I+ 
Sbjct: 652  DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIRE 711

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-K 1318
            QW  L+  S  R+++L  +  L +++ D  ++  WM +   + +    G      Q+L K
Sbjct: 712  QWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 771

Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
            +H+    E+   R  ++ L +     L +      D++ RL G+  +++ +      R  
Sbjct: 772  KHKDVAEEIANYRPTLDTLHEQA-SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 830

Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
             LQ      ++  +    +  +++ E  L + +  + L   + +Q R + LE E    A+
Sbjct: 831  ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS 890

Query: 1439 KMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
            ++A +  +A  +  S    E      + ++  Q  L  R  Q +  V+  +   LS + +
Sbjct: 891  RVAVVNQIARQLMHSGHPSE------KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSI 944

Query: 1499 -----------SWVAEHMP-HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLS 1546
                       SW+ E      S       L G  +L RK   ++ ++ A + ++  +  
Sbjct: 945  QNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQK 1004

Query: 1547 SGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
                L +    QAQ I+ +  E+   W E++   + R   L +A   QQ+  D+ + + W
Sbjct: 1005 EAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSW 1064

Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
            +   +  ++S D         +L+ +H+ ++ E+  Y    +++    + +T  +   Q 
Sbjct: 1065 LSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQY 1124

Query: 1667 RVVQERLR---EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
              +++RL+        L ++   R   L  +    +FLR+ +  + +L +Q+      E 
Sbjct: 1125 MFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE- 1183

Query: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
            +    E A     K   F   ++   +++ A       L+  G+     ++++   +   
Sbjct: 1184 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR 1243

Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
              +  E        L+D     +  +D  E+   + EK  +  +    +   L ++   H
Sbjct: 1244 HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKH 1303

Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRA 1902
            Q    EL   +  L + +E  G +Q +   P+  A V+++   + + W VL+   + +  
Sbjct: 1304 QAFMAELASNKEWLDK-IEKEG-MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1361

Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
            +L  A     F  +  D   W   +   +Q ++  ++ +S  + L   Q L  ++E R+K
Sbjct: 1362 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1421

Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE 2022
              ++  Q   QAL   G  T EV  +   +Q +  ++ +    ++  L A ++   F R+
Sbjct: 1422 EIEE-LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1480

Query: 2023 CGRLEEIL-AAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-- 2078
                +EIL   + + L TS   G +++ V+ LI+K++   K +     +   + ER +  
Sbjct: 1481 VE--DEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1538

Query: 2079 -----TLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
                 +L    +R RL  L Q    + E  E R   L  +     +   A +AE W+   
Sbjct: 1539 VTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQ 1598

Query: 2134 AQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ 2193
               +       D +  +  L KHQ  E  V+ + E +  ++K   AL+A SHP +  +S 
Sbjct: 1599 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISM 1658

Query: 2194 RLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
            R   + K +  L+     R  +L++R    +  + VD  E WI E+EV     +LGQD E
Sbjct: 1659 RQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYE 1718

Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
            H   L+ R REF  ++    +G   + +++ L+ +L N    +   I + +  LN  WA 
Sbjct: 1719 HVTMLQERFREFARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1776

Query: 2314 FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
                +    Q L  + E+H    +   +  RIQ+K   +   + G+D  +V+ L R H  
Sbjct: 1777 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTT 1835

Query: 2374 LEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
             E ++  +  QV  L+ +  RL    + + A  ++ R+ EV E+W  L    + RR  L 
Sbjct: 1836 FEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLV 1895

Query: 2433 ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSIS 2492
                  +  +M+++L++  + +  Q++    PR       ++  HQ  KAE+D+  DS +
Sbjct: 1896 DTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFT 1955

Query: 2493 LARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK 2552
                 G+ LL   H  S +I++ L  L ++   +   W++    L+  LE+  F      
Sbjct: 1956 TCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASV 2015

Query: 2553 MERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             E WL  +E  L+S  +   +  +E L+ +H+  E        + SALE
Sbjct: 2016 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALE 2064



 Score =  301 bits (770), Expect = 1e-80
 Identities = 366/1758 (20%), Positives = 702/1758 (39%), Gaps = 137/1758 (7%)

Query: 596  RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
            R+  LEQ  +R  F R     E WL E  + V     G DL  +  A +KH+A+E ++  
Sbjct: 403  RQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA 460

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
            ++     +V   R+L A           R + V   W+ L   +  R  RL+  L + + 
Sbjct: 461  YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKI 520

Query: 716  FADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRA 775
            F +      W+ E +  +     G+     E LL++H  +E       A++    E+ R 
Sbjct: 521  FQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE-------ADIGIQAERVRG 573

Query: 776  ASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQT 835
             +A A  F  +                         G+ +K           DP  I   
Sbjct: 574  VNASAQKFATD-------------------------GEGYKPC---------DPQVIRDR 599

Query: 836  QDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLE 895
              H+   Y+ L  LA  RRARLEE+  L+ F     E + W+ ++  +L       D   
Sbjct: 600  VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 659

Query: 896  VMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL 953
            VM+L  K+  F   ++   G + +     E +       S +I+ +   + ++W  LE L
Sbjct: 660  VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 719

Query: 954  KREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
               +  +L  +  +  F  +       + D+L  + +   G  E +  +  L +K   V 
Sbjct: 720  SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS--LVKKHKDVA 777

Query: 1014 ERRVHFLQSVVVKVEEPG-----YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQA 1068
            E   ++  ++    E+       +AES  ++G++  ++   K+V E    R +   +T A
Sbjct: 778  EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837

Query: 1069 RQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
                  E+    LW +  +  L + ++   +   + +    + L  E++    R+  ++ 
Sbjct: 838  LYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQ 897

Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
             ++ +     P  +E+      L  +  + + L ++++  L   L +Q +  E       
Sbjct: 898  IARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE------- 950

Query: 1189 CANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
            C   ++W+           +LG D+   ++L ++     R L  +  +   L+   EKL 
Sbjct: 951  CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL- 1009

Query: 1241 QSQHP-AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
            +S+HP  A  +  +L  I   W  ++   + R   L  + +LQ++ +D+ +   W+   +
Sbjct: 1010 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1069

Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQ-- 1356
              +A+ +         + L +HE  ++E+       + ++ +G E++++   GQ D Q  
Sbjct: 1070 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQ---GQTDAQYM 1125

Query: 1357 ---TRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
                RLQ L + W  L++    R + L Q+   +Q LR  + A+  L   E  L  +E  
Sbjct: 1126 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1185

Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHL 1464
              L  ++   K+ +   +       K+ A+       ++ G   S  I E+      +H 
Sbjct: 1186 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1245

Query: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
            +  E     L    ++L+ + +L +F         W+ E M      SY E  N   S  
Sbjct: 1246 KNRETASELL----MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN-LHSKW 1300

Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEAR 1583
             KH+    E+ +++  + ++   G  L  S  P+ + +V E+   L   W  LE   + +
Sbjct: 1301 LKHQAFMAELASNKEWLDKIEKEGMQL-ISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1359

Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
            AQ L  A   + +    ++L+ W+      + S DYG+D  +   L+ K Q L+ ++ + 
Sbjct: 1360 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1419

Query: 1644 WSSMEELDQTAQTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
               +EEL   AQ L     +  EV  ++  VQ +  E L  L E    R   L  +  +H
Sbjct: 1420 KKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE----RKHNLLASKEIH 1475

Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
            +F R+ ED   W+  +   A   +  G + +    L  K    Q +++    R+      
Sbjct: 1476 QFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534

Query: 1759 AESLLERGHS-AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
            +++++    S +   +RQR  DL+  W  L E T+ R   L +     + + D  E    
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1594

Query: 1818 VQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQA 1876
            + E+    +    A+D     + L+ HQ LE+ +      + +L +T+ R       P++
Sbjct: 1595 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS-RALVADSHPES 1653

Query: 1877 HAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEES 1936
              +  RQ  V + +A L+   E+RR +L+    L +    V D   W A           
Sbjct: 1654 ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA----------- 1702

Query: 1937 SQEPSSGPLKLSAHQWLRAELEAREKLWQQAT-QLGQQALLAAGTPTKEV----QEELRA 1991
             +E  +G  +L         L+ R + + + T  +GQ+ +        E+      +   
Sbjct: 1703 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAAT 1762

Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRL----EEILAAQEVSLK--TSALGSS 2045
            + + +D + + WA   E +    Q      E  +     +EI    +   K     LG  
Sbjct: 1763 IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRD 1822

Query: 2046 VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKE---- 2101
               VE L R H  F   + A   +   L+E    L+     D+   + +R   V E    
Sbjct: 1823 QNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKS 1882

Query: 2102 ---LAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
                 ESR   L  +     F         W++   +Q++    P D+      +  HQ 
Sbjct: 1883 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1942

Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
             +AE+ A  +  T+  + G++LLA+ H  + E+ ++L  L +  +++      R + L  
Sbjct: 1943 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2002

Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
                 +F +   +AEAW+  +E  ++  ++GQ ++   +L +R   F  ++A      + 
Sbjct: 2003 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2062

Query: 2279 IRSISDLSLQLKNRDPEE 2296
            +  ++ L L    R  EE
Sbjct: 2063 LERLTTLELLEVRRQQEE 2080



 Score =  167 bits (422), Expect = 2e-40
 Identities = 174/832 (20%), Positives = 336/832 (40%), Gaps = 81/832 (9%)

Query: 480  WQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
            W+ L    Q + +++ D        Q        L  L+   +S   G+ L  V  LL++
Sbjct: 1349 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1408

Query: 540  HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
              +LE Q+      +  L  Q   L S  G S + + +K  T+      L+  +  R+  
Sbjct: 1409 QQMLENQMEVRKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN 1467

Query: 600  LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
            L  + +  +F R+ E+E  W+ E      +   G +L  +   ++K++ L+ E+  HQ  
Sbjct: 1468 LLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPR 1527

Query: 660  CVDLVRRGRDLSARRPPTQPDP-GERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
              D+  R +++         +   +R   ++  W LL      R  RL+ A    QY+ D
Sbjct: 1528 IDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFD 1587

Query: 719  AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
            AAEA +W+ E+   +      +D+ +A ++L++H  LE+ +  +A  + +L +  RA  A
Sbjct: 1588 AAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVA 1647

Query: 779  RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
             +                           HP                  +   I   Q  
Sbjct: 1648 DS---------------------------HP------------------ESERISMRQSK 1662

Query: 839  LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQPQADTLEV 896
            + + Y  L+ LA+ RR +L+E   LF       +L+ W+ ++ V+     +    + + +
Sbjct: 1663 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM 1722

Query: 897  MQLKYENFLTALA-VGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKR 955
            +Q ++  F      +G+     V+  A++L      ++  I   ++ L++ W  L  L  
Sbjct: 1723 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1782

Query: 956  EKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLER 1015
             +   LA S E+  F  +      +++D   +L   + G  ++T   LQ   +     E 
Sbjct: 1783 TRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQ---RMHTTFEH 1838

Query: 1016 RVHFLQSVVVKVEEPG------YA--ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
             +  L + V +++E        YA  ++  +Q +   +    K + +    R  R  +T 
Sbjct: 1839 DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG 1898

Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLD 1127
             +  F    + L+LW E V  Q+ ++E   DV+S + L+  HQ +  EI    +      
Sbjct: 1899 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI 1958

Query: 1128 AQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA 1187
               + + A     S+E+   L  L ++ +E+   WE R +WL+  LE+ +F R+     A
Sbjct: 1959 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2018

Query: 1188 TCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAA 1247
                 + +L    +G+ V E   L+++H  F +  +T   R  AL               
Sbjct: 2019 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL--------------- 2063

Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKG 1299
                E+L +++    R Q   E+R+R+  +     +  ++     QW   KG
Sbjct: 2064 ----ERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKG 2111



 Score =  148 bits (374), Expect = 8e-35
 Identities = 141/613 (23%), Positives = 263/613 (42%), Gaps = 26/613 (4%)

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
            A+E   ++ K+   A + + W+++ + +   + +  SL  V+  Q Q  N    +     
Sbjct: 284  AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQ-QLQAFNTYRTVEKPPK 342

Query: 2913 LT-----RVVLGTGYKLVQAGHFAAH---------EVAARVQQLEKAMAHLRAEAARRRL 2958
             T      V+L T    ++A +   +         ++    ++LEKA  H R  A R  L
Sbjct: 343  FTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA-EHERELALRNEL 401

Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
            + Q+  E  A++F  +     +WL+E   ++  ++ G    A +A  ++ EA + D+ A+
Sbjct: 402  IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAY 461

Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
              R++ +   A  LE+    +  ++ A+   V      LL    AR   L+  L L ++ 
Sbjct: 462  EERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIF 521

Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE--VQSLGQAKVYALRKLA 3134
            +E L +  W+        SQDYG+ L GV+ L +K      +  +Q+     V A  +  
Sbjct: 522  QEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKF 581

Query: 3135 GTLERGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
             T   G     P +   R + +E  ++ L Q    R   L  +  +  F    AE +G +
Sbjct: 582  ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 641

Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA-CRLGQLHPAAP- 3251
            +EK  ++  +D G  L+SV  L  +HR  E E+        +   E    + + H  +  
Sbjct: 642  REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 701

Query: 3252 --GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAE 3309
                +  ++E WA L+  +  R + L +A+  H F     ++ AW  +  ++ SS ++  
Sbjct: 702  IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH 761

Query: 3310 DVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQE 3369
            D    + L+ +H+++ +EI   R     L ++   L    H  S +V   L  +E R +E
Sbjct: 762  DEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKE 820

Query: 3370 LEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQD 3429
            + E   LR Q   ++  L K+    +  E W+   E  L        + D+E++ HR + 
Sbjct: 821  VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES 880

Query: 3430 LEKLLAAQEEKFA 3442
            LE  +  Q  + A
Sbjct: 881  LEPEMNNQASRVA 893


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score =  929 bits (2401), Expect = 0.0
 Identities = 616/2134 (28%), Positives = 1062/2134 (49%), Gaps = 89/2134 (4%)

Query: 5    YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
            +E   I+ L      +Q+KTFTKW+N+     +   +I +LYT+L DG  L++LLE++SG
Sbjct: 40   FERSRIKALADEREAVQKKTFTKWVNS--HLARVSCRITDLYTDLRDGRMLIKLLEVLSG 97

Query: 65   EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
            E LP P++GR+R+H LEN  +AL FL+  +V +  +G  +IVDG+  L LGLIW IILRF
Sbjct: 98   ERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRF 157

Query: 124  QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
            QI  IS++ E+   +    S K+ALL+WCQ KTA Y NVNI +F+ SW DG+ FNALIH 
Sbjct: 158  QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHK 214

Query: 184  HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
            HRPDL+D+  L+     +NL  AF +AEQ LG+ +LLDPED++   PDE+SI+TYV  YY
Sbjct: 215  HRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYY 274

Query: 244  HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
            HY S++       +R+ K+L    ETE +  +YE L +DLL WI +  + L  R F +SL
Sbjct: 275  HYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSL 334

Query: 304  PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
              ++Q L AF  +RT EKPP+  ++G  E LLF +Q+ ++A N++ ++P EG  ++++++
Sbjct: 335  VGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINK 394

Query: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
             W  LE AE  R  AL+  L++ ++LE LARRF  KAA+RE++L + ++++ Q       
Sbjct: 395  AWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFD 453

Query: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
            L  VEAA ++   +E  I   E R QA+  +A  L  E YH    +  R++ V   W+ L
Sbjct: 454  LPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYL 513

Query: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
            L+ L+ +R+++     +  + QE+      ++E++    S   G+ L  V +LLQ+H L+
Sbjct: 514  LELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV 573

Query: 544  EAQVSAHGAHVSHL---AQQTA-ELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
            EA +      V  +   AQ+ A + +       +V++ +   +    Q L  L   RRA 
Sbjct: 574  EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 633

Query: 600  LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
            LE++ +  +F     EEE W++E  + + +   G+DL+ +   L KH+A E E+      
Sbjct: 634  LEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGH 693

Query: 660  CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
                ++ G D+ A          ER   ++  W  L+     R  RL+ A L+ Q+ ADA
Sbjct: 694  FEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA 753

Query: 720  AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
             +  +W+ +    +  +  G D+ + ++L+++H  +   +  +   L  L EQ  A    
Sbjct: 754  DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL--- 810

Query: 780  ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
                        P E   +P      S                                +
Sbjct: 811  ------------PQEHAESPDVRGRLS-------------------------------GI 827

Query: 840  SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQ--PQADTLEVM 897
             + Y+ +  L +LR+  L++ +AL+   S     +LW++++   L  +Q   + + LEV+
Sbjct: 828  EERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVI 887

Query: 898  QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
            Q ++E+    +       A V+  A QL      +  +I+ QQ++L+ RW Q   L   K
Sbjct: 888  QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRK 947

Query: 958  AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------L 1011
               L  ++ + ++  EC  T+  +R+    +E+ Q     D    + L +K T      +
Sbjct: 948  KDALLSALSIQNYHLECNETKSWIREKTKVIESTQ-DLGNDLAGVMALQRKLTGMERDLV 1006

Query: 1012 VLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQS 1071
             +E ++  LQ    K+E     ++Q +  ++  +  + ++++  +  R     E    Q 
Sbjct: 1007 AIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQ 1066

Query: 1072 FLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQ 1131
            FL++      W    Q  + S+++   +  A++LL +H+++  EI  ++E  Q++    +
Sbjct: 1067 FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE 1126

Query: 1132 PMAALDCPDSQE--VPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
             M      D+Q   +   L+ L     EL  +WE RQ  L +    Q+F R+     A  
Sbjct: 1127 -MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1185

Query: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
             N +  L    +   +  A + +++  +F   +     +  A+   G +LV   +  +  
Sbjct: 1186 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR 1245

Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
            ++E++ SI  +  + +  + +   +L  +  LQ++ QD  EL  W+ EK L A       
Sbjct: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305

Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
             RN+     +H+A  +EL + +  ++ +++ G +L+S +P  +  ++ +L GL   WE L
Sbjct: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVL 1365

Query: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
                  +   L  A + E   +   D  + L  LE  +QS + G+DL S   L K+ Q L
Sbjct: 1366 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1425

Query: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQK-----HLRRLELLQGHLAIRGLQLQAS 1484
            E++      ++  L S A  ++      +E          + +ELL+  L  R   L AS
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLE-PLNERKHNLLAS 1484

Query: 1485 VELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRV 1544
             E+HQF      E+ WV E MP  + T +   L   Q L +K++ LQ E++ HQ ++  +
Sbjct: 1485 KEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI 1544

Query: 1545 LSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL 1603
                +++   S    A+ I ++  +L+  W  L    E R + L++A   QQY+ D +E 
Sbjct: 1545 FERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA 1604

Query: 1604 EGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP 1663
            E W+ E+   + S +  +DE + + ++ KHQ L++ +  Y  ++ +L +T++ L     P
Sbjct: 1605 EAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1664

Query: 1664 EQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGG 1721
            E +R+   Q ++ +    L++LA  R  +L+   RL +  RE +DL+ W+A +++   G 
Sbjct: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA-EREVVAGS 1723

Query: 1722 ESLGEDPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDL 1780
              LG+D EH   L  +F +F      +G +RV     LA+ L+  GHS    + + +  L
Sbjct: 1724 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1783

Query: 1781 QTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQL 1840
              AW++L EL   R   L  +    + + D  E+  ++Q+K   LP  + RD   +E   
Sbjct: 1784 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1843

Query: 1841 RSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR 1900
            R H   E ++     Q+++L E A R+Q    G +A  +Q+R+  V +AW  L    E R
Sbjct: 1844 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1903

Query: 1901 RAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
            R +L       RF + VRD   W   V + ++ +E  ++ SS  L ++ HQ ++AE++AR
Sbjct: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963

Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFL 2020
               +    +LG+  L      ++E++E+L  L ++R ++   W  + E L+   +   F 
Sbjct: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023

Query: 2021 RECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL 2080
            R+    E  L  QE  L +  +G SV+EVE+LI++HE F K     D++ +AL ERL TL
Sbjct: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL 2082

Query: 2081 RRPRV--------RDRLPILLQRRMRVKELAESR 2106
                V        R R P   +   +V E AES+
Sbjct: 2083 ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQ 2116



 Score =  563 bits (1452), Expect = e-160
 Identities = 475/1960 (24%), Positives = 875/1960 (44%), Gaps = 144/1960 (7%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW  L +    R  ALR+      + ++ LE L +  ++  ++             
Sbjct: 391  DINKAWERLEKAEHERELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
             +N   DL  +EA  + H+ +E ++   E ++Q ++  A  ++        H +++   R
Sbjct: 447  QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELE----AENYHDIKRITAR 502

Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
            +  V + W  L   +  RR +LE    L +    +     W   ++  +  ++  +    
Sbjct: 503  KDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLG 562

Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE-----VQEELRALQDQRD 1997
                L  H  + A++  + +   +      Q     G   K      +++ +  ++    
Sbjct: 563  VEDLLQKHTLVEADIGIQAER-VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 621

Query: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
            ++ Q  A ++ RL+  ++   F  E    E  +  +E  L +   G  +  V +L+ KH 
Sbjct: 622  ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681

Query: 2058 VFLKVLTAQDKK-EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRGHALH 2111
             F   ++ +    E A++E    +        ++R+R+  + ++   +++L+  R   L 
Sbjct: 682  AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741

Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL-RDKLKP---LLKHQAFEAEVQAHE 2167
             + L+  F   A    D I AW   + + V   D+  D+      + KH+    E+  + 
Sbjct: 742  EASLLHQFQADA----DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 797

Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQ 2227
              + ++ ++  AL  Q H  + +V  RL G+ + ++++ +   LR Q L+D     +   
Sbjct: 798  PTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 856

Query: 2228 RVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSL 2287
              D  E WI EKE  +N   + + LE    ++ R               A +  I+   +
Sbjct: 857  EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLM 916

Query: 2288 QLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQE 2347
               +   +E+K    ++ +LN RW+ F   + R +  L  AL I     E +     I+E
Sbjct: 917  HSGHPSEKEIKA---QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIRE 973

Query: 2348 KEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
            K  +I++  D G DL  V  L RK   +ER++  I+A++  L++E  +L    P+ A  +
Sbjct: 974  KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1033

Query: 2407 RHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPA 2463
              R  E+++ W ++++   K REA  +L +A KLQ  L++L        R +  + +   
Sbjct: 1034 LSRLAEISDVWEEMKTTL-KNREA--SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1090

Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQ 2521
            P +  EA ++L +H+  K E+D++ +     R  G+ ++T G   +    +RQ L  L+ 
Sbjct: 1091 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRLQALDT 1149

Query: 2522 ELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW 2581
              + L   W+  Q  L Q+   Q FL   ++ E +L ++E  LA   +   L   E  + 
Sbjct: 1150 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIK 1209

Query: 2582 KHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRH 2641
            K +     ++    KI+A+  T R L   G+  +     +  ++  R       A     
Sbjct: 1210 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1269

Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
            RL++ R LQ FLQD QE++ W+ EK L A +    +   L ++  K Q F AEL ++   
Sbjct: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329

Query: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
              ++++EG +L+         ++E+L  L  +W  L+  +Q K  +L  A +A    +S 
Sbjct: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSC 1389

Query: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
             +L+ WL  +E ++++   G+ L  V  LL  Q+ LE  ++ + ++ E L  QAQA  +E
Sbjct: 1390 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1449

Query: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLA 2881
            G     +V+ +   +  +F  L EPL ER+  L A   + +F RD ++E+ WV E++PLA
Sbjct: 1450 GKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLA 1508

Query: 2882 AAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLV-QAGHFAAHEVAARVQ 2940
             + D+G +L  V+ L +++Q L+ E+  H+     +      +V  +   +A  +  R+ 
Sbjct: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568

Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
             L++    L  E  +R   L++A  AQQ+  +  EA +W++E+   + SE+     ++  
Sbjct: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            ++L++ +  ++ +E ++  + +L +T+  L +  +PES ++  +   V + +A L   AE
Sbjct: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1688

Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
             R   L E+ +L QL RE   L+ W+  +   A S + GQD E V +L+E+F  F ++  
Sbjct: 1689 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1748

Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
            ++GQ +V  +  LA  L          I   +  +  AW  L + I  RT+ LAA++E+H
Sbjct: 1749 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1808

Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
             F   A E+ GR+Q+K   +  E+ G   ++V TLQ+ H   E +++A+  +V +LQ +A
Sbjct: 1809 KFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA 1867

Query: 3241 CRLGQLHPAAPGGLA--------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELL 3292
             R   L  A  G  A        +V EAW +L    + R   L        F    ++L+
Sbjct: 1868 AR---LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM 1924

Query: 3293 AWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFM 3352
             W ++      ++E   DV+  E L+  H+ +  EI           + G+ L+   H+ 
Sbjct: 1925 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYA 1984

Query: 3353 SAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPD 3412
            S E+ E L +L  + +E+ + W  RW+       + +  +    AEAWL   E  L   +
Sbjct: 1985 SEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2044

Query: 3413 YGHSVSDVELLLHRHQDLEKLLAAQEEKFA-----------QMQKTEMEQELLLQPQELK 3461
             G SV +VE L+ RH+  EK  A  +E+F+           ++++ + E+E   +P   +
Sbjct: 2045 IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPE 2104

Query: 3462 PGRAGS--SLTSFQWRPS-----GHQGLGAQ-----LAETRD------------------ 3491
            P    S  + +  QW  S        GL A+     +AET D                  
Sbjct: 2105 PSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKES 2164

Query: 3492 ------------------------PQDAKGTPT--MEGSLEFKQHLLPGGRQPSSSSWDS 3525
                                    P   + TP+  MEG L  K       ++ SS SW +
Sbjct: 2165 SPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHN 2224

Query: 3526 CRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGAE 3583
                +    +  + D + AA  +   S   + L  A CE       +KH F LRL  G E
Sbjct: 2225 VYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNE 2284

Query: 3584 ILFAAPSEEQAESWWRALGSTAA---QSLSPKLKAKPVSS 3620
             LF A  +E+  +W +A+ S  +     +S   ++ P SS
Sbjct: 2285 YLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASS 2324



 Score =  436 bits (1121), Expect = e-121
 Identities = 394/1832 (21%), Positives = 794/1832 (43%), Gaps = 89/1832 (4%)

Query: 1254 LQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHE 1305
            +  I   W RL+    +R   L   L  QE  + +A            W+ E   + + +
Sbjct: 389  ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448

Query: 1306 PSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
              G     ++   K+HEA E+++ A    V+A+  V REL +      + I  R   +  
Sbjct: 449  NFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR 508

Query: 1365 KWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK 1424
             WE L   +  R   L+     +++ +++    + +++++  + S + G+ L   + L +
Sbjct: 509  LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQ 568

Query: 1425 RHQQLESESRTLAAKMAALASMAHGMAAS--------PAILEETQKHLRRL--ELLQGHL 1474
            +H  +E++    A ++  + + A   A          P ++ +   H+     EL Q   
Sbjct: 569  KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ-LA 627

Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
            A R  +L+ S  L +F      E  W+ E     S   Y + L     L  KH+  + E+
Sbjct: 628  AERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEM 687

Query: 1535 KAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQ 1594
                G  ++ +  G  + A  H  ++ I E+   +   WA LE+    R + L++A    
Sbjct: 688  SGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 747

Query: 1595 QYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
            Q+  D  +++ W+ +   +VSS D G DE +T  L+ KH+ + EE+A Y  +++ L + A
Sbjct: 748  QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 807

Query: 1655 QTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
              L       P+V  +   ++ER +E    + EL   R + L+ TL L++   EA+  + 
Sbjct: 808  SALPQEHAESPDVRGRLSGIEERYKE----VAELTRLRKQALQDTLALYKMFSEADACEL 863

Query: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
            W+  +K+       + E  E    +  +F   + ++   + RVA    +A  L+  GH +
Sbjct: 864  WI-DEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS 922

Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-- 1827
               ++ +Q  L T WS+  EL   +  AL    +    H +  E  + ++EK   + +  
Sbjct: 923  EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 982

Query: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
            ++  DL G+ A  R   G+ER+LV  E +L +L + A +++   P  QA A+  R   ++
Sbjct: 983  DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEIS 1041

Query: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
              W  ++  ++ R A L  A  L +F   + D+ SW +R +  +  E+     +     L
Sbjct: 1042 DVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1101

Query: 1948 SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWA 2004
            + H+ ++ E++  E+ +Q+   +G+  ++  G    +   +++ L+AL    +++++ W 
Sbjct: 1102 TQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE 1159

Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
             +Q  L      Q FLR+  + E  L  QE  L  + + +++E  E  I+K E F+  + 
Sbjct: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMD 1219

Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
            A ++K  A+ E  + L         R+++++  +  R  + +E A      L  +  +  
Sbjct: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279

Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
            F Q   +   WI        + +   + R+     LKHQAF AE+ +++E +  + K+G 
Sbjct: 1280 FLQDCQELSLWINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM 1338

Query: 2179 ALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQE 2238
             L+++       V ++L GL K WE L      + Q L D      F Q     + W+  
Sbjct: 1339 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHG 1398

Query: 2239 KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLK--NRDPEE 2296
             E ++   D G+DL     L ++ +            +   + I +L  Q +  +++ + 
Sbjct: 1399 LESQIQSDDYGKDLTSVNILLKKQQMLENQM------EVRKKEIEELQSQAQALSQEGKS 1452

Query: 2297 VKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD 2356
               +  +R  +  ++      L   +  L  + EIH  +R++++    + E+  L  + D
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512

Query: 2357 CGKDLESVQRLLRKHEELEREVHPIQAQVESL-EREVGRLCQRSPEAAHGLRHRQQEVAE 2415
             G +L++VQ L++K++ L++E+   Q +++ + ER    +   S  +A  +R R  ++ +
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1572

Query: 2416 SWWQLRSRAQKRREALDALHQAQK--LQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRM 2473
             W  L    +KR   L+  H+AQ+    A   E  +S Q L   M +    +    A  M
Sbjct: 1573 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL--YMMSEEKAKDEQSAVSM 1630

Query: 2474 LEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH 2533
            L++HQ  +  ++ + +++     T + L+   HP S  I    + +++  + L+   +E 
Sbjct: 1631 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1690

Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL-EV 2592
            + +L +   L      V+ +E+W+  +E    S  L      +  L  + +    D   +
Sbjct: 1691 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750

Query: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
               ++  +   A  L   GH +A +       +      L     TR   L    +L  F
Sbjct: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1810

Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRL 2712
              D++E+   +++K+    EE   D   +    +    F+ ++ A   Q ++LQ +  R 
Sbjct: 1811 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR- 1869

Query: 2713 LQGGHPASEA--IQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
            LQ  +   +A  IQ+R  E+   W  L D  + +  +L    +  R    + +L  W+E 
Sbjct: 1870 LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1929

Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE 2830
            +  ++ A    + +  V  L+   + ++A +D +       +   ++ +   H  +++++
Sbjct: 1930 VIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1989

Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
            E+  +L ++ K + +  ++R   L     + +F RDA    AW+  + P  ++++ GQS+
Sbjct: 1990 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV 2049

Query: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
              V  L ++H+  E   ++ +                  F+A E    ++ LE       
Sbjct: 2050 DEVEKLIKRHEAFEKSAATWDE----------------RFSALERLTTLELLEVRRQQEE 2093

Query: 2951 AEAARR-------RLLLQQAQEAQQFLT---ELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
             E  RR         + ++A+  QQ+ T   E +      AE+G    +E +  ++E   
Sbjct: 2094 EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETV-DTSEMVN 2152

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032
                +  ++K      SP  +R  +TA   +S
Sbjct: 2153 GATEQRTSSKESSPIPSPTSDRKAKTALPAQS 2184



 Score =  392 bits (1006), Expect = e-108
 Identities = 381/1789 (21%), Positives = 759/1789 (42%), Gaps = 75/1789 (4%)

Query: 868  SSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL-- 925
            S   +L  W+E QT+++   +  A++L  +Q + + F T   V K        + E L  
Sbjct: 309  SLASDLLEWIE-QTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367

Query: 926  --RQRYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECG 975
              + +   N+ ++   +E     ++++ W +LE  + E+ + L + +   E    L    
Sbjct: 368  TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRF 427

Query: 976  PTQVQLRDVLLQLEALQPGSSEDT----CHALQLAQKKTLVLE-------RRVHFLQSVV 1024
              +  +R+  L     Q   S+D       A++ A KK   +E        RV  + +V 
Sbjct: 428  DRKAAMRETWLSEN--QRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVA 485

Query: 1025 VKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAE 1084
             ++E   Y + + +  + + +  L + + E +  R +R       Q   QE   ++ W +
Sbjct: 486  RELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 545

Query: 1085 SVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAA-----LDCP 1139
             ++  + S++    +   + LL++H  +  +I +  ER++ ++A +Q  A        C 
Sbjct: 546  EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC- 604

Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1199
            D Q + + +  +    QEL  L  +R+  L+E   L KF  E+          +  L  D
Sbjct: 605  DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD 664

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
            + G+D+   + LL +HR F   +S      E     GE ++  +H  +  +RE++  I+ 
Sbjct: 665  DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIRE 724

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-K 1318
            QW  L+  S  R+++L  +  L +++ D  ++  WM +   + +    G      Q+L K
Sbjct: 725  QWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 784

Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
            +H+    E+   R  ++ L +     L +      D++ RL G+  +++ +      R  
Sbjct: 785  KHKDVAEEIANYRPTLDTLHEQA-SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843

Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
             LQ      ++  +    +  +++ E  L + +  + L   + +Q R + LE E    A+
Sbjct: 844  ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS 903

Query: 1439 KMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
            ++A +  +A  +  S    E      + ++  Q  L  R  Q +  V+  +   LS + +
Sbjct: 904  RVAVVNQIARQLMHSGHPSE------KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSI 957

Query: 1499 -----------SWVAEHMP-HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLS 1546
                       SW+ E      S       L G  +L RK   ++ ++ A + ++  +  
Sbjct: 958  QNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQK 1017

Query: 1547 SGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
                L +    QAQ I+ +  E+   W E++   + R   L +A   QQ+  D+ + + W
Sbjct: 1018 EAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSW 1077

Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
            +   +  ++S D         +L+ +H+ ++ E+  Y    +++    + +T  +   Q 
Sbjct: 1078 LSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQY 1137

Query: 1667 RVVQERLR---EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
              +++RL+        L ++   R   L  +    +FLR+ +  + +L +Q+      E 
Sbjct: 1138 MFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE- 1196

Query: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
            +    E A     K   F   ++   +++ A       L+  G+     ++++   +   
Sbjct: 1197 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR 1256

Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
              +  E        L+D     +  +D  E+   + EK  +  +    +   L ++   H
Sbjct: 1257 HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKH 1316

Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRA 1902
            Q    EL   +  L + +E  G +Q +   P+  A V+++   + + W VL+   + +  
Sbjct: 1317 QAFMAELASNKEWLDK-IEKEG-MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374

Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
            +L  A     F  +  D   W   +   +Q ++  ++ +S  + L   Q L  ++E R+K
Sbjct: 1375 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1434

Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE 2022
              ++  Q   QAL   G  T EV  +   +Q +  ++ +    ++  L A ++   F R+
Sbjct: 1435 EIEE-LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1493

Query: 2023 CGRLEEIL-AAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-- 2078
                +EIL   + + L TS   G +++ V+ LI+K++   K +     +   + ER +  
Sbjct: 1494 VE--DEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551

Query: 2079 -----TLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
                 +L    +R RL  L Q    + E  E R   L  +     +   A +AE W+   
Sbjct: 1552 VTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQ 1611

Query: 2134 AQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ 2193
               +       D +  +  L KHQ  E  V+ + E +  ++K   AL+A SHP +  +S 
Sbjct: 1612 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISM 1671

Query: 2194 RLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
            R   + K +  L+     R  +L++R    +  + VD  E WI E+EV     +LGQD E
Sbjct: 1672 RQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYE 1731

Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
            H   L+ R REF  ++    +G   + +++ L+ +L N    +   I + +  LN  WA 
Sbjct: 1732 HVTMLQERFREFARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1789

Query: 2314 FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
                +    Q L  + E+H    +   +  RIQ+K   +   + G+D  +V+ L R H  
Sbjct: 1790 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTT 1848

Query: 2374 LEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
             E ++  +  QV  L+ +  RL    + + A  ++ R+ EV E+W  L    + RR  L 
Sbjct: 1849 FEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLV 1908

Query: 2433 ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSIS 2492
                  +  +M+++L++  + +  Q++    PR       ++  HQ  KAE+D+  DS +
Sbjct: 1909 DTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFT 1968

Query: 2493 LARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK 2552
                 G+ LL   H  S +I++ L  L ++   +   W++    L+  LE+  F      
Sbjct: 1969 TCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASV 2028

Query: 2553 MERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             E WL  +E  L+S  +   +  +E L+ +H+  E        + SALE
Sbjct: 2029 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALE 2077



 Score =  301 bits (770), Expect = 1e-80
 Identities = 366/1758 (20%), Positives = 702/1758 (39%), Gaps = 137/1758 (7%)

Query: 596  RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
            R+  LEQ  +R  F R     E WL E  + V     G DL  +  A +KH+A+E ++  
Sbjct: 416  RQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA 473

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
            ++     +V   R+L A           R + V   W+ L   +  R  RL+  L + + 
Sbjct: 474  YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKI 533

Query: 716  FADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRA 775
            F +      W+ E +  +     G+     E LL++H  +E       A++    E+ R 
Sbjct: 534  FQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE-------ADIGIQAERVRG 586

Query: 776  ASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQT 835
             +A A  F  +                         G+ +K           DP  I   
Sbjct: 587  VNASAQKFATD-------------------------GEGYKPC---------DPQVIRDR 612

Query: 836  QDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLE 895
              H+   Y+ L  LA  RRARLEE+  L+ F     E + W+ ++  +L       D   
Sbjct: 613  VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 672

Query: 896  VMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL 953
            VM+L  K+  F   ++   G + +     E +       S +I+ +   + ++W  LE L
Sbjct: 673  VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 732

Query: 954  KREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
               +  +L  +  +  F  +       + D+L  + +   G  E +  +  L +K   V 
Sbjct: 733  SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS--LVKKHKDVA 790

Query: 1014 ERRVHFLQSVVVKVEEPG-----YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQA 1068
            E   ++  ++    E+       +AES  ++G++  ++   K+V E    R +   +T A
Sbjct: 791  EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850

Query: 1069 RQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
                  E+    LW +  +  L + ++   +   + +    + L  E++    R+  ++ 
Sbjct: 851  LYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQ 910

Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
             ++ +     P  +E+      L  +  + + L ++++  L   L +Q +  E       
Sbjct: 911  IARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE------- 963

Query: 1189 CANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
            C   ++W+           +LG D+   ++L ++     R L  +  +   L+   EKL 
Sbjct: 964  CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL- 1022

Query: 1241 QSQHP-AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
            +S+HP  A  +  +L  I   W  ++   + R   L  + +LQ++ +D+ +   W+   +
Sbjct: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082

Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQ-- 1356
              +A+ +         + L +HE  ++E+       + ++ +G E++++   GQ D Q  
Sbjct: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQ---GQTDAQYM 1138

Query: 1357 ---TRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
                RLQ L + W  L++    R + L Q+   +Q LR  + A+  L   E  L  +E  
Sbjct: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198

Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHL 1464
              L  ++   K+ +   +       K+ A+       ++ G   S  I E+      +H 
Sbjct: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1258

Query: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
            +  E     L    ++L+ + +L +F         W+ E M      SY E  N   S  
Sbjct: 1259 KNRETASELL----MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN-LHSKW 1313

Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEAR 1583
             KH+    E+ +++  + ++   G  L  S  P+ + +V E+   L   W  LE   + +
Sbjct: 1314 LKHQAFMAELASNKEWLDKIEKEGMQL-ISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1372

Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
            AQ L  A   + +    ++L+ W+      + S DYG+D  +   L+ K Q L+ ++ + 
Sbjct: 1373 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1432

Query: 1644 WSSMEELDQTAQTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
               +EEL   AQ L     +  EV  ++  VQ +  E L  L E    R   L  +  +H
Sbjct: 1433 KKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE----RKHNLLASKEIH 1488

Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
            +F R+ ED   W+  +   A   +  G + +    L  K    Q +++    R+      
Sbjct: 1489 QFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547

Query: 1759 AESLLERGHS-AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
            +++++    S +   +RQR  DL+  W  L E T+ R   L +     + + D  E    
Sbjct: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1607

Query: 1818 VQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQA 1876
            + E+    +    A+D     + L+ HQ LE+ +      + +L +T+ R       P++
Sbjct: 1608 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS-RALVADSHPES 1666

Query: 1877 HAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEES 1936
              +  RQ  V + +A L+   E+RR +L+    L +    V D   W A           
Sbjct: 1667 ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA----------- 1715

Query: 1937 SQEPSSGPLKLSAHQWLRAELEAREKLWQQAT-QLGQQALLAAGTPTKEV----QEELRA 1991
             +E  +G  +L         L+ R + + + T  +GQ+ +        E+      +   
Sbjct: 1716 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAAT 1775

Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRL----EEILAAQEVSLK--TSALGSS 2045
            + + +D + + WA   E +    Q      E  +     +EI    +   K     LG  
Sbjct: 1776 IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRD 1835

Query: 2046 VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKE---- 2101
               VE L R H  F   + A   +   L+E    L+     D+   + +R   V E    
Sbjct: 1836 QNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKS 1895

Query: 2102 ---LAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
                 ESR   L  +     F         W++   +Q++    P D+      +  HQ 
Sbjct: 1896 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1955

Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
             +AE+ A  +  T+  + G++LLA+ H  + E+ ++L  L +  +++      R + L  
Sbjct: 1956 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2015

Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
                 +F +   +AEAW+  +E  ++  ++GQ ++   +L +R   F  ++A      + 
Sbjct: 2016 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2075

Query: 2279 IRSISDLSLQLKNRDPEE 2296
            +  ++ L L    R  EE
Sbjct: 2076 LERLTTLELLEVRRQQEE 2093



 Score =  168 bits (425), Expect = 1e-40
 Identities = 193/930 (20%), Positives = 370/930 (39%), Gaps = 104/930 (11%)

Query: 480  WQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
            W+ L    Q + +++ D        Q        L  L+   +S   G+ L  V  LL++
Sbjct: 1362 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1421

Query: 540  HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
              +LE Q+      +  L  Q   L S  G S + + +K  T+      L+  +  R+  
Sbjct: 1422 QQMLENQMEVRKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN 1480

Query: 600  LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
            L  + +  +F R+ E+E  W+ E      +   G +L  +   ++K++ L+ E+  HQ  
Sbjct: 1481 LLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPR 1540

Query: 660  CVDLVRRGRDLSARRPPTQPDP-GERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
              D+  R +++         +   +R   ++  W LL      R  RL+ A    QY+ D
Sbjct: 1541 IDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFD 1600

Query: 719  AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
            AAEA +W+ E+   +      +D+ +A ++L++H  LE+ +  +A  + +L +  RA  A
Sbjct: 1601 AAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVA 1660

Query: 779  RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
             +                           HP                  +   I   Q  
Sbjct: 1661 DS---------------------------HP------------------ESERISMRQSK 1675

Query: 839  LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQPQADTLEV 896
            + + Y  L+ LA+ RR +L+E   LF       +L+ W+ ++ V+     +    + + +
Sbjct: 1676 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM 1735

Query: 897  MQLKYENFLTALA-VGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKR 955
            +Q ++  F      +G+     V+  A++L      ++  I   ++ L++ W  L  L  
Sbjct: 1736 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1795

Query: 956  EKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLER 1015
             +   LA S E+  F  +      +++D   +L   + G  ++T   LQ   +     E 
Sbjct: 1796 TRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQ---RMHTTFEH 1851

Query: 1016 RVHFLQSVVVKVEEPG------YA--ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
             +  L + V +++E        YA  ++  +Q +   +    K + +    R  R  +T 
Sbjct: 1852 DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG 1911

Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLD 1127
             +  F    + L+LW E V  Q+ ++E   DV+S + L+  HQ +  EI    +      
Sbjct: 1912 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI 1971

Query: 1128 AQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA 1187
               + + A     S+E+   L  L ++ +E+   WE R +WL+  LE+ +F R+     A
Sbjct: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031

Query: 1188 TCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAA 1247
                 + +L    +G+ V E   L+++H  F +  +T   R  AL               
Sbjct: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL--------------- 2076

Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS 1307
                E+L +++    R Q   E+R+R+  +     +  ++     QW   KG   +    
Sbjct: 2077 ----ERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGL 2132

Query: 1308 GARRNILQ--------------TLKRHEAAESELL----ATRRHVEALQQVGRELLSRRP 1349
             A +   +              T +R  + ES  +    + R+   AL       L  R 
Sbjct: 2133 PAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPART 2192

Query: 1350 CGQEDIQTRLQGL---RSKWEALNRKMTER 1376
              QE    +++G    + +WEA N+K + R
Sbjct: 2193 --QETPSAQMEGFLNRKHEWEAHNKKASSR 2220



 Score =  148 bits (374), Expect = 8e-35
 Identities = 141/613 (23%), Positives = 263/613 (42%), Gaps = 26/613 (4%)

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
            A+E   ++ K+   A + + W+++ + +   + +  SL  V+  Q Q  N    +     
Sbjct: 297  AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQ-QLQAFNTYRTVEKPPK 355

Query: 2913 LT-----RVVLGTGYKLVQAGHFAAH---------EVAARVQQLEKAMAHLRAEAARRRL 2958
             T      V+L T    ++A +   +         ++    ++LEKA  H R  A R  L
Sbjct: 356  FTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA-EHERELALRNEL 414

Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
            + Q+  E  A++F  +     +WL+E   ++  ++ G    A +A  ++ EA + D+ A+
Sbjct: 415  IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAY 474

Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
              R++ +   A  LE+    +  ++ A+   V      LL    AR   L+  L L ++ 
Sbjct: 475  EERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIF 534

Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE--VQSLGQAKVYALRKLA 3134
            +E L +  W+        SQDYG+ L GV+ L +K      +  +Q+     V A  +  
Sbjct: 535  QEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKF 594

Query: 3135 GTLERGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
             T   G     P +   R + +E  ++ L Q    R   L  +  +  F    AE +G +
Sbjct: 595  ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654

Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA-CRLGQLHPAAP- 3251
            +EK  ++  +D G  L+SV  L  +HR  E E+        +   E    + + H  +  
Sbjct: 655  REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 714

Query: 3252 --GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAE 3309
                +  ++E WA L+  +  R + L +A+  H F     ++ AW  +  ++ SS ++  
Sbjct: 715  IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH 774

Query: 3310 DVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQE 3369
            D    + L+ +H+++ +EI   R     L ++   L    H  S +V   L  +E R +E
Sbjct: 775  DEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKE 833

Query: 3370 LEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQD 3429
            + E   LR Q   ++  L K+    +  E W+   E  L        + D+E++ HR + 
Sbjct: 834  VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES 893

Query: 3430 LEKLLAAQEEKFA 3442
            LE  +  Q  + A
Sbjct: 894  LEPEMNNQASRVA 906


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  879 bits (2271), Expect = 0.0
 Identities = 617/2173 (28%), Positives = 1045/2173 (48%), Gaps = 98/2173 (4%)

Query: 5    YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
            +E   I+ L      +Q+KTFTKW+N+     +   +I +LY +L DG  L++LLE++SG
Sbjct: 40   FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97

Query: 65   EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
            E LP P++G++R+H LEN  +AL FL+  +V +  +G  +IVDG+  L+LGLIW IILRF
Sbjct: 98   EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157

Query: 124  QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
            QI  I +  +E        S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH 
Sbjct: 158  QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214

Query: 184  HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
            HRPDL+D+  L+     HNL  AF VAE++LGI  LLDPEDV    PDE+SI+TYV  +Y
Sbjct: 215  HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274

Query: 244  HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
            HY S++       +R+ K++    ETE +  +Y  L +DLL WI +    L +R F +SL
Sbjct: 275  HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334

Query: 304  PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
              ++Q L AF+ +RT EKPP+ Q++G  E LLF +Q+ ++A N++ + PH+G  ++++++
Sbjct: 335  TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394

Query: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
             W  LE AE  R  AL+  L++ ++LE LARRF  KAA+RE++L + ++++ Q       
Sbjct: 395  AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453

Query: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
            LA VEAA ++   +E      E R +AL ++A  L +E YH    +  R++ +   W  L
Sbjct: 454  LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513

Query: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
             + LQ +R+++    A+  L Q++  +   ++E++    S   G+ L EV +LLQ+H L+
Sbjct: 514  QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573

Query: 544  EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            EA ++  G  V  +   T +     G      +V+Q +   L Q  + L  +   R+A L
Sbjct: 574  EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633

Query: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
            EQ+ +  +F    +E E+W+KE  Q   +   G+DL+ +    +KHKA E E+    A  
Sbjct: 634  EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693

Query: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
              + +    + AR+    P    R + V   W  L+         LQ A    Q+  DA 
Sbjct: 694  EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753

Query: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
            +  +WL++    L     GQD+ A   L ++H      L      +  LE+Q +      
Sbjct: 754  DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                                                      P+   D   +      L 
Sbjct: 810  ------------------------------------------PEEFRDSPDVTHRLQALR 827

Query: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899
            + Y+ + A A LR+ RL+EA+ L+         +LW+ EK+  L +   P  DTLE +++
Sbjct: 828  ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885

Query: 900  KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
                F       K L  +   V+ +A  L +     S ++++ Q+ L+ RW   + L  E
Sbjct: 886  VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945

Query: 957  KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016
            +   +  ++ V ++  +C  T   + D    +E+ +     D    + + Q+K   LER 
Sbjct: 946  RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003

Query: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069
            V  +Q+ V  ++ E     +S P Q    GQ +  L+ L + +Q+ +  +     E    
Sbjct: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063

Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128
            Q+FLQ+      W    Q  + S+++   +  A++LL++H  + +EI   Q+  Q++ ++
Sbjct: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123

Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
              + +     P+   +   L  L      L  +WE R   L + L  Q+F ++     A 
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183

Query: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
             +N +  L      + +  A + +++  +F   +     +  +    G KLV   +  + 
Sbjct: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243

Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
             ++E++Q I+ +  +   ++++    L  +L+LQ + Q+  EL  W+ +K L +      
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303

Query: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
              RN+     +H+A  +EL +    +E +   G++L+  +P     +  +L+ L   W+ 
Sbjct: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363

Query: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
            L     E+   L  A   +  L+   D  + +  +E  L+S + G+DL S  R+  + ++
Sbjct: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423

Query: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488
            +E +      ++  L +    M       + + +  R L+LL+  L  R  QL++S    
Sbjct: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481

Query: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
            Q       E  WV E +P      Y   L   Q   +K++ LQ E+  H  +V+ VL  G
Sbjct: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541

Query: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608
            + L  +     Q + E+   L+  W  L  A   R Q L+ A   QQY+LD  E E W+ 
Sbjct: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601

Query: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668
            E+   V S +  +DE   + ++ +H   Q  +  Y  ++++L   AQ L     PE +++
Sbjct: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661

Query: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726
            +  Q ++ +    L+++A  R R+LE    L +  RE +DL+ W+ S+K+       +G+
Sbjct: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720

Query: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785
            D +H   L  KF  F  +   +G +RV       E L++ GHS    + + +  L   W+
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780

Query: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845
            +L EL   R   L  +    R      E+L  + EK   LP +V  D    E+  R H  
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840

Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
             EREL     Q+Q+  + A R+Q    G +A A+Q ++Q V+ AW  L      RR QL 
Sbjct: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900

Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965
                  RF +  RD  SW   + + ++ +E  ++ SS  L +  HQ + AE+E R K + 
Sbjct: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960

Query: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025
               +LG+  L      ++E++E+L+ +  +R ++ + W  + ERL+   +   F R+   
Sbjct: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020

Query: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
             E  L AQE  L +   G +V+ VE+LI++HE F       +K  A+  ER   L +P  
Sbjct: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073

Query: 2086 RDRLPILLQRRMRVKELAESRG-------HALHASLLMASFTQAATQAEDWIQAWAQQLK 2138
             +     L+ R   +  AE  G        A  A +   + T+  +  E+    W Q L+
Sbjct: 2074 LE-----LKERQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPGEE-EGTWPQNLQ 2127

Query: 2139 EPVPPGDLRDKLK 2151
            +P PPG  +D  K
Sbjct: 2128 QPPPPGQHKDGQK 2140



 Score =  531 bits (1369), Expect = e-150
 Identities = 483/1943 (24%), Positives = 842/1943 (43%), Gaps = 126/1943 (6%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW  L E    R  ALR+      + ++ LE L +  ++  ++             
Sbjct: 391  DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
             +N   DL  +EA  + H+ +E +    E +++ L + A  ++K     Q   +  R+  
Sbjct: 447  QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505

Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
            + + W+ LQ  ++ RR +LE    L +    +     W   ++  L   E  +       
Sbjct: 506  ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565

Query: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002
             L  H+ + A++  +    +  T    +     G      + +Q+ +  L+   +++   
Sbjct: 566  LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625

Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062
             A ++ +L+  ++   F  E    E  +  +E    +   G  +  V  L RKH+ F   
Sbjct: 626  AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685

Query: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
            L   D       +EA      K    P++  R+  +  +  ++K+LA      L  +   
Sbjct: 686  LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745

Query: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175
              F   A   + W+Q  A +L      G      + L  KH+ F  E++    VM  + +
Sbjct: 746  FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            + +    +    + +V+ RLQ LR+ ++ +     LR Q L++  +        D  E W
Sbjct: 805  QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863

Query: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            + EKE    +M + D  +DLE  +Q R  + +    +    +    + + S   ++  + 
Sbjct: 864  MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
               EVK   Q +  LN RW +F   +   ++ ++ AL +H    + +  +K I +K  ++
Sbjct: 921  RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977

Query: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
            ++  D G+DL  +  + RK   LER+V  IQA+V++LERE  +L    PE    +  RQ+
Sbjct: 978  ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037

Query: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465
             + E W  L+   Q +    D L +  +LQA LQ+L      L   Q+  A  D    P 
Sbjct: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091

Query: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524
            S  EA ++L++H   K E+D   DS    + +G++++     P    + Q L GL+   +
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151

Query: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584
            +L   W+     L Q L  Q F    ++ E  L ++E +LA     D L   E  + K +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211

Query: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644
                 +E    K+ +   +   L   G+  +     + Q +  R      +A      L 
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271

Query: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704
            +  +LQ FLQ+ QE+  W+ +K L + +    +   L  +  K Q F AEL +     + 
Sbjct: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331

Query: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764
            +  EG++L+      +  + ++LE L  LW ELQ  +++K   L  A  +    ++  +L
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391

Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
              W+  +E +LR+   G+ L  V  +L   + +E  V+ +  +   L  Q  +   EG  
Sbjct: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451

Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884
                +E+       RF  L EPL  R+  LE+    L+  RD ++E  WV+E+LPLA + 
Sbjct: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504

Query: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
            DYG +L  V+   +++Q L++E+  H      VL  G +LV+A      ++  R+  L+ 
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564

Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004
            +   LR  AA R   L+ A EAQQ+  +  EA +W+ E+   + S+++    E    +L+
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624

Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
            R    +R +E +   I++L   A  L S  +PE  +++     V + +A L   AE R  
Sbjct: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684

Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
             L+    L QL+RET  L+ W++ K   A S + GQD + V +L +KF  F +E  ++GQ
Sbjct: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744

Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
             +V  +      L          I   +  +   W  L + I  R + LAA++++H +  
Sbjct: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804

Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243
              AE+ G + EK   +  ED G   S+  +  + H   EREL  +  +V + Q  A RL 
Sbjct: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863

Query: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299
                G+   A      +V  AW  L      R   L   A    F    ++LL+W +   
Sbjct: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359
                ++E   DV+  E L+  H+ +  EI           + G+ L+   H  S E+ E 
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983

Query: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419
            LQ++  R +E+ E W  RW+R      + +  +    AEAWL   E  L   D+GH+V  
Sbjct: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043

Query: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK---TEMEQELLLQ-------PQELKPGRAGSSL 3469
            VE L+ RH+  EK  A+  E+FA ++K    E+++  + +       PQE +   AG + 
Sbjct: 2044 VEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAP 2103

Query: 3470 TSF-----QWRPSGHQGL-----------------------------------------G 3483
             S      +  P   +G                                          G
Sbjct: 2104 VSHHAATERTSPGEEEGTWPQNLQQPPPPGQHKDGQKSTGDERPTTEPLFKVLDTPLSEG 2163

Query: 3484 AQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLDERM 3543
             + A    P+D   +  MEG L  K  L    ++ S+ SW++    L+ S L+ + D + 
Sbjct: 2164 DEPATLPAPRDHGQSVQMEGYLGRKHDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKN 2223

Query: 3544 AAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRAL 3601
             A  +       L L  A CE       +KH F LRL++G+E LF    EE+  SW + +
Sbjct: 2224 LALGMPYHGEEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGV 2283

Query: 3602 GSTAAQSLSPKLKAK--PVSSLN 3622
             +   +S S ++KA+  P+ SL+
Sbjct: 2284 STAINESQSIRVKAQSLPLPSLS 2306



 Score =  399 bits (1026), Expect = e-110
 Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)

Query: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
            H  KLV   + A  ++ E      A++ R L  R+E  R++ L  L  + + +  A    
Sbjct: 384  HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436

Query: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
            W+ E   + A +  G     ++  K+ HEA E++  A    V AL+ + +EL       Q
Sbjct: 437  WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496

Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
            + I  R   +   W  L   +  R   L+     ++L + +  + + +++++  L S+E 
Sbjct: 497  KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556

Query: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465
            G+ L   + L ++H+ +E++      K+ A+ +               P ++++   HL 
Sbjct: 557  GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616

Query: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
            +  E L    A R  QL+ S  L +F    +   SW+ E     S   Y + L     L 
Sbjct: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676

Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581
            RKHK  + E++     ++++      + A    GHPQ   I  + +E+   W +L+    
Sbjct: 677  RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733

Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
               + LQ A  F Q+  D  +L+ W+++   L+S  D G+DE AT  L  KH+   EEL 
Sbjct: 734  FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793

Query: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694
                 ME L+Q AQ       PE+ R   + +  +L+AL+EL       A  R + L+  
Sbjct: 794  ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847

Query: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
            L L+    E +  + W+  +++  A        ED E   H   +F     +++    ++
Sbjct: 848  LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904

Query: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809
                L A SL+E GH     V+Q Q  L T W     L   R  A+   ++ LRVH    
Sbjct: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961

Query: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
            D  E    + +K   + +  ++ RDL G+ A  R   GLER++   + ++  L   + ++
Sbjct: 962  DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021

Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927
                P  Q   + QRQ+ + + W  LQ+ ++ +   L     L  F   + D+ +W +  
Sbjct: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986
            ++ +  E+  +        L  H  ++ E++  +  +Q+  + G++ +     P    + 
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            + L  L    + + + W  +   L      Q F ++  + E IL+ QE +L       S+
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098
            E  E  IRK E FL        KVL+  D     + E    L   ++++++ ++  R  +
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258

Query: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
              E A+     L  +L + +F Q   +   WI        + V   + R+     LKHQA
Sbjct: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317

Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
            F AE+ +HE  + ++  +G+ L+ +       VSQ+L+ L + W++L+     + Q L  
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377

Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276
             R+    LQ       WI   E ++   D G+DL    ++  +L+  E + N   + +G+
Sbjct: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437

Query: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
              A + S+     D  L ++ R  + ++ + +R+ QL +  A                  
Sbjct: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482

Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
               +SR+L++ T  ++E+  L Q+ D G +L++VQ  ++K++ L+ E+     +VE + +
Sbjct: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539

Query: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448
               +L + +      L  R   +  SW +LR  A  R + L   ++AQ+  L A   E  
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599

Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508
            +  Q L    D    P+    A  ML+ H   +  ++ +  +I    S  Q LL+AGHP 
Sbjct: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657

Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
               I ++   +++  + L+   +E + +L+    L       + +E+W+  KE   +S  
Sbjct: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717

Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625
            +      +   L + K  ++  E  A    ++  + A    L   GH EA +       +
Sbjct: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775

Query: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
                  L     TR   L     L  +     E+   + EK+    E+  LD +   +  
Sbjct: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835

Query: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744
            +    F+ EL     Q Q+ Q    RL        +EAIQ + +E+ A W  L D    +
Sbjct: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895

Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804
              +L    +  R      +L +W+E I  ++      + +  V  L+   + + A ++ +
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955

Query: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864
            ++   A L   ++ ++  H  ++++ E+ ++++ R K + E  + R   L     + +F 
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015

Query: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
            RDA    AW+  + P  A+ D+G ++ +V  L ++H+  E   +S
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060



 Score =  324 bits (831), Expect = 9e-88
 Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)

Query: 872  ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927
            +L  W+E QT+ +   +  A++L  +Q + + F T   V K    +   + E L    + 
Sbjct: 313  DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371

Query: 928  RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979
            R   N+ ++    +     ++++ W  LE  +  + + L + +   E    L      + 
Sbjct: 372  RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431

Query: 980  QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029
             +R+  L   Q    Q     D   A++ A+KK       T   E RV  L+ +  ++E+
Sbjct: 432  AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490

Query: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089
              Y + + +  + + +  L   +QE +  R +R   T A Q   Q+    + W + ++A 
Sbjct: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550

Query: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146
            L S E    +   + LL++H+ +  +I +  ++++ + A +            D Q + +
Sbjct: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610

Query: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206
             +  L Q  +EL  +   R+  L++   L KF  E+D   +     +      + G+D+ 
Sbjct: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670

Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
              L L ++H+ F   L  L    E +      +V  +      +  +++ + AQW +L+ 
Sbjct: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730

Query: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325
             +   ++ L  +    +++ D  +L  W+++   + + E  G      + L K+H+    
Sbjct: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790

Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
            EL  +R  +E L+Q  +           D+  RLQ LR  ++ +  +   R   LQ+A  
Sbjct: 791  ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849

Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
               +  +    +  + + E  L   E    L   + +Q R   L+ E +TL  ++  +  
Sbjct: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909

Query: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
             A+ +  S       +++ Q HL  R +  Q  ++ R   + +++ +H +C        W
Sbjct: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969

Query: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
            + +       T      L G  ++ RK   L+ +V A Q +V  +    + L  S   Q 
Sbjct: 970  ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029

Query: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
            + I ++ + LE  W  L+++ + +   L +    Q +  D+ + + W+   +  V+S D 
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676
                    +L+ +H  +++E+  +  S + + ++ +  + G   PE   + Q  E L   
Sbjct: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149

Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
              AL  +  +R   L   L   EF ++A+  +  L++Q+      E   +  E A     
Sbjct: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            KF  F   +E    +V +       L+  G+     ++++ Q ++    +  E  Q    
Sbjct: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856
             LRD        ++  E+   + +K  +  +    +   L  +   HQ    EL   E  
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328

Query: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
            L E ++  G+ Q +   PQ  A V Q+ +A+ + W  LQ   +++   L  AR       
Sbjct: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386

Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971
               D   W + +   L+ ++  ++ +S    L+  + +  ++  R+    +L+ Q   +G
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446

Query: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
            ++   A  +  K   + L  L  ++ Q+  + A+ Q     E             E +  
Sbjct: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494

Query: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085
             + + L  SA  G++++ V+  ++K++    ++L    + E  L+   + +    +    
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554

Query: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
              +RL  L     R++E A  R   L  +     +   A +AE WI      +     P 
Sbjct: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614

Query: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203
            D    +  L +H   +  V+ +   +  +A + + LL+  HP  GE   RLQG + KH+ 
Sbjct: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673

Query: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263
             L+     R ++LE+  +  +  +  D  E WI EKE+  +  ++GQD +H   LR + R
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733

Query: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323
            +F   +    +G   + +++    +L +    E   I + +  LN  WA     +    Q
Sbjct: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791

Query: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383
             L  + ++H        +   I EK   +   D G D  + +   R H   ERE+H +  
Sbjct: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850

Query: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
            QV+  +    RL    + E A  +++++QEV+ +W  L      RR  L       +  +
Sbjct: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
            M ++LL   + +  Q++T   PR       +++ HQ   AE+++ + + S     G+ LL
Sbjct: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970

Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
               H  S +IR+ L  +      +   W+    +L+  LE+  F       E WL ++E 
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030

Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             LAS      +  +E L+ +H+  E      A + +ALE
Sbjct: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069



 Score =  299 bits (765), Expect = 4e-80
 Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)

Query: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417
            WE+L     R+     +EL +  + EQL R+           L + +  +     G DL 
Sbjct: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455

Query: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472
            + +  +K+H+ +E+++     ++ AL  +A  +          I       LR    LQ 
Sbjct: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515

Query: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532
             L  R  +L+ ++ L +        + W+ E   H     + + L   + L +KHK ++ 
Sbjct: 516  LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575

Query: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589
            ++     +V+ + ++          Q    Q I ++   LE  + EL      R   L+Q
Sbjct: 576  DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635

Query: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
            +    ++F ++ E E W++EK  + SS DYG+D  + L L  KH+A ++EL    + +E+
Sbjct: 636  SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695

Query: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706
            + Q A  +   +     ++ + R++E   Q   L++LAA   + L+      +F  +A+D
Sbjct: 696  IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754

Query: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766
            L+ WL    +   G E +G+D      L  K   F  ++E     +      A+   E  
Sbjct: 755  LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813

Query: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826
              + P V  R Q L+  + ++      R   L++      V  +       + EK   L 
Sbjct: 814  RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872

Query: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
                 D L  LE        L++E+     Q+  +   A  + +    P++  V+Q Q  
Sbjct: 873  EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931

Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
            +   W   Q  + +RR  ++ A  +  +     + + W     + ++  +      +G +
Sbjct: 932  LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991

Query: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001
                KLS  +   A ++AR    ++ +Q   Q + +     +++ +  + L++    + Q
Sbjct: 992  AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048

Query: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061
            +   +++ L    Q Q FL++    +  L+  + ++ +  +  S+ E EQL+++H     
Sbjct: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108

Query: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113
             +         ++E  + + + +  D   +LL +R+         +  + ESR H L   
Sbjct: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167

Query: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173
            L    F + A QAE  +      L    PP  L      + K + F   ++ + + + S 
Sbjct: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229
               G  L+A+ +  + ++ +++Q +    RK+ E  ++A  L    LE  +NFL+  Q +
Sbjct: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286

Query: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289
             L   WI +K +     D+  D      L  +  + +   A     +  + +I     QL
Sbjct: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339

Query: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349
             +  P+   ++ Q+   L+  W           Q L  A    +  +   ++ K I   E
Sbjct: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399

Query: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409
              +++ D GKDL SV R+L K + +E +V+  + ++  L  +V  + +   +A   +  R
Sbjct: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459

Query: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469
              ++ E   + + + +  R  L      +     ++E L  AQ   A   T+        
Sbjct: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512

Query: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529
             +  ++++Q  + E+   T  +      GQQL+ A      D+ + L  L+     L  A
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572

Query: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
                  +L+ A E Q +    ++ E W+  +E  + S+ +         +L +H   +  
Sbjct: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632

Query: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648
            +E     I  L + A+GL   GHPE +  + R Q  + +  A  +  A  R+ +LE +  
Sbjct: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691

Query: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706
            L    +++ ++  W+ EK LVA    +  D   +     K ++F  E  A    +   + 
Sbjct: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751

Query: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766
               +RL+  GH  +  I E  + L  +W +L +    ++  L  + +  R   +  E+  
Sbjct: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811

Query: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814
             ++      P +V L A T      V  A      LLG Q  ++   D   R   A  G+
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869

Query: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874
                       A+ ++ + + +   +++L +    RRT L   +   +FF  A + ++W+
Sbjct: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919

Query: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934
            +  +     Q+  + +S+V  L + HQ + +E+ +        L  G  L+Q  H A+ E
Sbjct: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979

Query: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994
            +  ++QQ+      +  +   R   L+   E  QF  +   A +WL  +   L S D GH
Sbjct: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039

Query: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053
            + ++ + L++R EA ++   +++ R   L++   L L+ R+  E P   A+    +E   
Sbjct: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096

Query: 3054 ELLRRAEARGHGLQEQ 3069
            E    A    H   E+
Sbjct: 2097 ETAGEAPVSHHAATER 2112



 Score =  165 bits (417), Expect = 9e-40
 Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)

Query: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778
            + ++   W  L++   ++   L      Q+  E L  R  R     E WL   +  +   
Sbjct: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448

Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
              G  L  V         +E        +  AL   AQ   +E +   + +  +   +L+
Sbjct: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508

Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  L+E LQ RR  LE    L K F+D    + W+ E      + ++G+ L  V  L +
Sbjct: 509  LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955
            +H+ +E++++      + +     K  +   +   +   +  R+  LE+    L   AA 
Sbjct: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628

Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
            R+  L+Q++   +F  E+ EA SW+ E+  +  S D G    +   L R+ +A + +L  
Sbjct: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688

Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
                +E++ Q A  + +RK    P++ A+++ V     +L   A      LQ+     Q 
Sbjct: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748

Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
            + +   L AWL         +D GQD    + L +K   F +E++       +  ++  G
Sbjct: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808

Query: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
              E  R +P     +QA R   +    + D     R + L  A ++++        +  M
Sbjct: 809  FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864

Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253
             EK   +   +   +L  +  +Q +   L++E++ +  ++  +   A  L +        
Sbjct: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924

Query: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308
            + + Q+     W   Q    ER + +  A + H +   C+E   W  ++ ++  S+++L 
Sbjct: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984

Query: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368
             D+AG   +  +   L +++   + +   L +E QQL+D+      ++ +  + LE   Q
Sbjct: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044

Query: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428
             L+++   +     E   LQ   Q L+  +AWL+  +  +   D   S+ + E LL +H 
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104

Query: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481
             ++  +   ++ + +++++       + + E LL  Q L+    G +     W    H  
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163

Query: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513
            L   L      +DAK    +  + E+   HL P
Sbjct: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196



 Score =  143 bits (361), Expect = 3e-33
 Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909
            A+E   ++ K+   A + + W+++ + +  ++ +  SL+ V + LQ    ++ +E     
Sbjct: 297  AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356

Query: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960
             E     V+L T    ++A +   +  H+    V  + +A      A  R E A R  L+
Sbjct: 357  QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415

Query: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
            +Q    Q A++F  +     +WL+E   ++  ++ G+   A +A  ++ EA + D  A+ 
Sbjct: 416  RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475

Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077
             R+  L+  A  LE     +  ++ A+   +    + L    ++R   L+  L L +L +
Sbjct: 476  ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535

Query: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136
            + L    W+    A   S ++G+ L  V+ L +K      ++   G + K      L  T
Sbjct: 536  DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595

Query: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
              +G     P  IQ + S +E  +E L      R   L  +  +  F     E +  ++E
Sbjct: 596  EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655

Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251
            K  +    D G  L+SV  LQ++H+  E EL  ++  + ++  EA     R    HP   
Sbjct: 656  KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715

Query: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
              + +V   W  L+  A    + L  A     F G   +L AW Q+   L S E++ +D 
Sbjct: 716  ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775

Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
                 L  +H++  +E+ E R   + L Q+ Q   +     S +VT  LQ L    Q++ 
Sbjct: 776  GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834

Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
                LR QR  E+  L  +    +  E W+   E  L + +   ++ D+E++ HR   L+
Sbjct: 835  AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894

Query: 3432 K 3432
            +
Sbjct: 895  Q 895


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score =  872 bits (2254), Expect = 0.0
 Identities = 664/2274 (29%), Positives = 1070/2274 (47%), Gaps = 109/2274 (4%)

Query: 3    SQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELI 62
            S +E   I+ L      +Q+KTFTKW+N+     + G  I +LY +L DG  L RLLE++
Sbjct: 45   SLFECSRIKALADEREAVQKKTFTKWVNS--HLARVGCHIGDLYVDLRDGFVLTRLLEVL 102

Query: 63   SGEALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIIL 121
            SGE LP P+RGR+R+H LEN  +AL FL+  +V +  +G  +IVDG+  L LGL+W IIL
Sbjct: 103  SGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIIL 162

Query: 122  RFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALI 181
            RFQI  I ++ E+   +    S K+ALL+WCQ KTA Y  VNI +F+ SW DGL FNALI
Sbjct: 163  RFQIQVIKIETED---NRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALI 219

Query: 182  HAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSL 241
            H HRPDL+D+  L      +NL  AF  AEQ LG+A+LLDPEDV    PDE+SI+TYV  
Sbjct: 220  HRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVS 279

Query: 242  YYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPD 301
            +YHY S++       +R+ K+L Q+ E   +  +YE+L A+LL WI      +  + F +
Sbjct: 280  FYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFAN 339

Query: 302  SLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
            SL  ++Q L AFT + T EKP + Q++G  E LLF +Q+ L+A NRR F+P EG G+ ++
Sbjct: 340  SLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDI 399

Query: 362  SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
             + W  LE AE  R  AL+  L++ ++LE LA+RF HK A+RES+L + ++++ Q     
Sbjct: 400  DKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-G 458

Query: 422  ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQ 481
              L  VEAA+++   +EA I   E R Q +AE+A  L  E Y+    VA +++ V  +W 
Sbjct: 459  YELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWA 518

Query: 482  RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
             L   +  +R ++    A+  + QE+      +EE+Q    S  CGQ L E  +LLQ+H 
Sbjct: 519  LLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHG 578

Query: 542  LLEAQVSAHGAHVSHL---AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
            LLE  ++A    V  L   A + ++L        +V+  +   +      L      RRA
Sbjct: 579  LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRA 638

Query: 599  LLEQTLQRAEFLRNCEEEEAWLKE---------------CGQRVGNAALGRDLSQIAGAL 643
             LE +      L+  EE E+W ++                    G A    DLS  A  L
Sbjct: 639  ELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLL 698

Query: 644  QKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDP--------GERAEAVQGGWQLL 695
             +HK L+ E+   +A+    +R G +L A      P           ERA + +  WQ L
Sbjct: 699  AQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRL 758

Query: 696  QTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRL 755
            +     R  RLQ A  + Q+ AD      WLR+          G D+A++  L R+H   
Sbjct: 759  EEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQH--- 815

Query: 756  ERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAW 815
                RA   E+     +G  +  R  L T+  A           GP   A          
Sbjct: 816  ----RALTGEVE--AHRGPVSGLRRQLATLGGA--------SGAGPLVVA---------- 851

Query: 816  KMALPAEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQ 874
                             LQ +     Q +  +  +A LRR  L +A+A++         +
Sbjct: 852  -----------------LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACE 894

Query: 875  LWL--EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGN 932
            LW+  ++Q +L  RV    D +EV+Q ++E+    +    G   +V+ + ++L +    +
Sbjct: 895  LWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPS 954

Query: 933  STQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQ 992
            S +++  Q+ L+ RW ++  L  ++  +++  + V + + E    + Q+R+    +E+  
Sbjct: 955  SDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVES-A 1013

Query: 993  PGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQV 1052
            P +       L   +     LE R   L      + E   A++  L    E L      +
Sbjct: 1014 PRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGAL 1073

Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE--VSVDVASAQRLLREHQ 1110
                       A     Q FL +    L W    Q      E  +   +  A  LL  H 
Sbjct: 1074 ASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHA 1133

Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPD---SQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
             L EE+   +E   ++ A S+ + A D  +      +   L  L     +L  LWE R++
Sbjct: 1134 ALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARRE 1193

Query: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
             L +    Q F R++        N +  L    L   V      L+QHR+F   +     
Sbjct: 1194 ALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQ 1253

Query: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
            + +      E L++  +      +E +  +  +    Q R++Q  ++L   L+LQ + +D
Sbjct: 1254 KMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRD 1313

Query: 1288 VAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSR 1347
              EL  W+ EK LMA          + +   RH+A  +EL   +  +E +++ G++L+  
Sbjct: 1314 CHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE 1373

Query: 1348 RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGAL 1407
            +P     ++ +L  +R  W  L      +  +L +A + +QL++   +  ++L  +E  L
Sbjct: 1374 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQL 1433

Query: 1408 QSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA---ILEETQKHL 1464
            Q  + G DL +     K+ Q +ES+      ++  L +    +   PA   ++ E Q  +
Sbjct: 1434 QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV 1493

Query: 1465 -RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
              RL  L   L  R   L AS ELHQ  H  + EL+WV E +P    T     L   Q  
Sbjct: 1494 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 1553

Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
             +K++ L+ E++AH  +++ VL    +LA+   P+A+ +    ++L+  WA L  A E R
Sbjct: 1554 IKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERR 1613

Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
             Q L  A   +QY+ DV+E+E W+ E+  L+ S D G+DE +TL+L+ KH  L++ +  Y
Sbjct: 1614 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 1673

Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFL 1701
              S+ +L +  + L     P+ +++   Q ++     AL+EL   R   LE    L++  
Sbjct: 1674 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLS 1733

Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM-GSQRVAACRLLAE 1760
            R+  +L+ W+A +K+   G   LG+D EH   L  KF++F  +  M G +R+AA   + +
Sbjct: 1734 RQVSELEHWIA-EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 1792

Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
             L+E GH+A   + + +  L  AW+EL EL   R   L  +    +   D  E+  Q++E
Sbjct: 1793 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 1852

Query: 1821 KATSLP--NNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA 1878
            K   LP             +  R+ +  E +L     Q+++L E A +++ +  G  A A
Sbjct: 1853 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 1912

Query: 1879 VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQ 1938
            +  R+Q V Q W  L    E  R  +       RF + VRD  SW   +   +   +  +
Sbjct: 1913 IASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR 1972

Query: 1939 EPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQ 1998
            + SS  + ++ HQ L+ ELEAR        +LG+  LL       E+Q +L  L  ++++
Sbjct: 1973 DVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEE 2032

Query: 1999 VYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEV 2058
            V + W R  E LQ   +   F +E    +  L AQE  L++  LGSSV+EVEQLIR+HE 
Sbjct: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEA 2092

Query: 2059 FLKVLTAQDKKEAALRERLKTLRRPRV-RDRLP--ILLQRRM--RVKELAESRGHALHAS 2113
            F K   A +++ ++LR RL T+ + +  + + P   LL R+      ELA      L   
Sbjct: 2093 FRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPG 2151

Query: 2114 LLMASFTQAATQAEDWIQAWAQ----QLKEPVPPGDLR---DKLKPLLKHQAFEAEVQAH 2166
                     A +A D + A  +     +++ + P  L+   D+L  +       A   A 
Sbjct: 2152 GYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211

Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
            E+   + A    A   +  P   E + R + L +     RQ    + +E   RR
Sbjct: 2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRR 2265



 Score =  441 bits (1135), Expect = e-123
 Identities = 439/1763 (24%), Positives = 762/1763 (43%), Gaps = 114/1763 (6%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW EL +    R  ALR       + ++ LE+L Q  +   ++             
Sbjct: 398  DIDKAWGELEKAEHEREAALRAE----LIRQEKLELLAQRFDHKVAMRESWLNENQRLVS 453

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGP--QAHAVQQRQ 1883
             +N   +L  +EA ++ H+ +E ++   E ++Q + E A   Q L          V  ++
Sbjct: 454  QDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELA---QALAAEGYYDIRRVAAQR 510

Query: 1884 QAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSG 1943
             +V + WA+L   +  RR +LE+   L +    +     W   ++  L   E  Q     
Sbjct: 511  DSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEA 570

Query: 1944 PLKLSAHQWLRAELEAR----EKLWQQATQLGQQALLAAGTPT-------------KEVQ 1986
               L  H  L  ++ A+    E L   A +  Q        P               E+Q
Sbjct: 571  DDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQ 630

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS- 2045
            E+    + + +     WA  QE  +AE     + R+  RL E       +    A G++ 
Sbjct: 631  EQAARRRAELEASRSLWALLQELEEAES----WARDKERLLEAAGGGGAAGAAGAAGTAG 686

Query: 2046 ----VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-----------------TLRRPR 2084
                +    +L+ +H++    L     + A L++ L+                 T+    
Sbjct: 687  GAHDLSSTARLLAQHKILQGELGG---RRALLQQALRCGEELVAAGGAVGPGADTVHLVG 743

Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
            + +R     +R  R++E A  R   L  +  +  F        DW++  A +L      G
Sbjct: 744  LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRD-AYRLAAAGDFG 802

Query: 2145 -DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKH 2201
             D     +   +H+A   EV+AH   ++ + ++   L   S   P    +  R+    + 
Sbjct: 803  HDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQL 862

Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKE---VKMNVGDLGQDLEHCLQL 2258
            + ++ +  ALR Q L D          V   E WI EKE   + M V D   D+E  +Q 
Sbjct: 863  FAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVE-VVQH 921

Query: 2259 RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNL 2318
            R    +   NS    V D    ++ +L ++  +   +EV+  CQ    LN+RW      +
Sbjct: 922  RFESLDQEMNSLMGRVLDVN-HTVQEL-VEGGHPSSDEVRS-CQ--DHLNSRWNRIVELV 976

Query: 2319 LRYQQQLEGAL--EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
             + ++++   L  E HVL  E+  V  +++EK   +++        +   L  +   LE 
Sbjct: 977  EQRKEEMSAVLLVENHVL--EVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEA 1029

Query: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436
             +  ++ +  +L  E   L +R P  A  L    +E+   W  L S AQ   EA+ A   
Sbjct: 1030 ALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAA--- 1086

Query: 2437 AQKLQAMLQEL------LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
            A +LQ  L +L      LV AQ      +  P P S  EA  +L  H   K E+D   + 
Sbjct: 1087 AGRLQRFLHDLDAFLDWLVRAQEAAGGSE-GPLPNSLEEADALLARHAALKEEVDQREED 1145

Query: 2491 ISLARSTGQQLLTA-----GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQL 2545
             +   +  + LL A     G   + D  + L  LE     L G W+  +  L QA   QL
Sbjct: 1146 YARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHIYQL 1203

Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATAR 2605
            FL  + +    L ++E +L+   L   +  +E  L +H+     +E+   K+      A 
Sbjct: 1204 FLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAE 1263

Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE 2665
            GL + G+   + A      +L + +    +A     +L +  +LQ FL+D  E+  W+ E
Sbjct: 1264 GLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE 1323

Query: 2666 KNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQE 2725
            K L+A +    D   L  +  + Q F AEL  +    ++++REGQ+L+Q     + ++++
Sbjct: 1324 KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK 1383

Query: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALP 2785
            +L E+   W EL+  +Q K  +L +A +A +L +S  EL+  L  +E +L+    G  L 
Sbjct: 1384 KLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA 1443

Query: 2786 GVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE 2845
             V   L   + +E+ V++  R+   L  Q  A   E     + V E+   + +R   L E
Sbjct: 1444 TVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLE 1502

Query: 2846 PLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLES 2905
            PLQERR  L A   L +   D D+E+AWVQE+LPLA   + G  L AV+   +++Q L  
Sbjct: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562

Query: 2906 EMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQE 2965
            E+ +H      VL     L       A  V   ++QL+ A A LR  A RR+ +L  A +
Sbjct: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622

Query: 2966 AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQ 3025
             +Q+  ++ E  +WL E+  ++ SED G   ++T  LL++    ++ +E +   I +L +
Sbjct: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682

Query: 3026 TAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAW 3085
                L    +P+S ++  +   V   +  L    E R   L++Q  L+QL R+   L+ W
Sbjct: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 1742

Query: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
            +  K   A S + GQD E V VL+EKF  F  E    G+ ++ A+ ++   L        
Sbjct: 1743 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802

Query: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGED 3204
              +   +  +  AW  L + +  R + LAA+ E+H F   A ELQG+++EK   L +   
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 1862

Query: 3205 GGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQE 3259
                  S  ++Q+  R  E +L+ +  +V +LQ  A +L     G+   A      +V +
Sbjct: 1863 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ 1922

Query: 3260 AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLG 3319
             W  L +  ++    ++  A    F  + ++LL+W         + +   DV+  E L+ 
Sbjct: 1923 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMN 1982

Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQ 3379
             H+ L  E+     +    ++ G+ L+ N   M+ E+   L +L  R +E+ E W   W+
Sbjct: 1983 YHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWE 2042

Query: 3380 RCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEE 3439
               +   + +  Q    A+AWL   E LL   + G SV +VE L+ RH+   K  AA EE
Sbjct: 2043 WLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEE 2102

Query: 3440 KFAQMQKTEMEQELLLQPQELKP 3462
            +F+ +++    +++  +  +  P
Sbjct: 2103 RFSSLRRLTTIEKIKAEQSKQPP 2125



 Score =  355 bits (910), Expect = 6e-97
 Identities = 407/1881 (21%), Positives = 778/1881 (41%), Gaps = 124/1881 (6%)

Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQE--------WKQDVAELMQWMEEKGLMAAHEPSG 1308
            I   W  L+    +R   L A L  QE        +   VA    W+ E   + + +  G
Sbjct: 399  IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFG 458

Query: 1309 ARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
                 ++  +K+HEA E+++ A    V+ + ++ + L +        +  +   +  +W 
Sbjct: 459  YELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWA 518

Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQ 1427
             L   +  R   L+Q    +++ +++    + +E+++  L S E GQ L  +  L ++H 
Sbjct: 519  LLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHG 578

Query: 1428 QLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLRR-LELLQGHLAIRGL 1479
             LE +    + ++ AL + A   +         P ++     H+   L  LQ   A R  
Sbjct: 579  LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRA 638

Query: 1480 QLQASVELHQFCHLSNMELSW------VAEHMPHGSPTSYTECLNGAQSLH--------- 1524
            +L+AS  L           SW      + E    G           A   H         
Sbjct: 639  ELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLL 698

Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASG---HPQAQ--HIV---EQCQELEGHWAEL 1576
             +HK LQ E+   +  +Q+ L  G  L A+G    P A   H+V   E+       W  L
Sbjct: 699  AQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRL 758

Query: 1577 ERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQAL 1636
            E A   R + LQ+A    Q+  D+  L  W+ +   L ++ D+G DEA++ RL  +H+AL
Sbjct: 759  EEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRAL 818

Query: 1637 QEELAIYWSSMEELDQTAQTLTGPE------VPEQQRVVQERLREQLRA-LQELAATRDR 1689
              E+  +   +  L +   TL G        V  Q RVV+    EQL A + E+AA R +
Sbjct: 819  TGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVE---AEQLFAEVTEVAALRRQ 875

Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQ---AAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
             L   L ++    E    + W+  ++Q   + +  +SL +D E   H   +F     ++ 
Sbjct: 876  WLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSL-DDVEVVQH---RFESLDQEMN 931

Query: 1747 MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLR 1806
                RV       + L+E GH +   VR  Q  L + W+ + EL + R   +        
Sbjct: 932  SLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVEN 991

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
               ++ EV  QV+EK  ++  +  R    L+ +L    GLE  L   E +   LLE A  
Sbjct: 992  HVLEVAEVRAQVREKRRAV-ESAPRAGGALQWRL---SGLEAALQALEPRQAALLEEAAL 1047

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
            + +  P  QA  + Q  + +   W  L    +     +  A  L RF   +  +  W  R
Sbjct: 1048 LAERFPA-QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106

Query: 1927 VRQDLQVEESSQEPSSGPLK-----LSAHQWLRAELEAREKLWQQATQLGQQALLAAGT- 1980
             +   +    S+ P    L+     L+ H  L+ E++ RE+ + +     +  L A G  
Sbjct: 1107 AQ---EAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163

Query: 1981 --PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK 2038
              P   + E L  L+    ++   W  ++E L      QLFLR+  +   +L  QE++L 
Sbjct: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALS 1223

Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVL-TAQDKKEAALRERLKTLRRPRV-----RDRLPIL 2092
             + L  +VE VE+ +++H  FL  +  +Q K + A++     LR+  +     ++ +  L
Sbjct: 1224 GAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283

Query: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKP 2152
            L++    +  A+     LH  L +  F +   + + WI       ++     D     K 
Sbjct: 1284 LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRE-DNHKLHKR 1342

Query: 2153 LLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
             L+HQAF AE+  ++E +  + ++G+ L+ +    A  V ++L  +R+ W +L      +
Sbjct: 1343 WLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAK 1402

Query: 2213 GQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGD 2272
             ++L +     + +Q     +  +   E ++   D G DL       ++L+        +
Sbjct: 1403 ARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM------E 1456

Query: 2273 TVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
            +  +   R + +L  Q      +P   +++ +R++ +  R       L   ++ L  + E
Sbjct: 1457 SQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKE 1516

Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
            +H ++ +LD+    +QE+  L    + G  L++VQ+ ++K++ L RE+     ++E +  
Sbjct: 1517 LHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLE 1576

Query: 2391 EVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449
              G L   RSPE A  +R   +++  +W  LR  A++R++ LDA  Q ++    + E+  
Sbjct: 1577 RAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEA 1635

Query: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFS 2509
                    M +    +      ++L++H + +  ++++ +SI+      + LL  GHP S
Sbjct: 1636 WLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS 1695

Query: 2510 SDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGL 2569
              I +  + +++   +L+   +E ++ L+Q   L      V ++E W+  KE    S  L
Sbjct: 1696 EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 1755

Query: 2570 WDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQAML 2626
                  +  L  + K  E+  E   AG  +++A+      L + GH  A +       + 
Sbjct: 1756 GQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 1813

Query: 2627 LRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTAML 2681
                 L    GTR   L   R+L  F  D++E+   + EK      L    E     + +
Sbjct: 1814 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873

Query: 2682 PAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNS 2741
               L+  ++    L + + Q QE   + + +  G H  +EAI  R +E+   W EL    
Sbjct: 1874 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLSAC 1931

Query: 2742 QKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAV 2801
            +     +    +ALR    + +L +W++ I  ++ A    + +  V  L+   + L+  +
Sbjct: 1932 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTEL 1991

Query: 2802 DKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLL 2861
            + +  +        ++ +     +A +++ Q  +L  R + + E        L+    + 
Sbjct: 1992 EARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVH 2051

Query: 2862 KFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTG 2921
            +F ++A    AW+  + PL  +++ G S+  V  L  +H+      ++ E          
Sbjct: 2052 QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEE--------- 2102

Query: 2922 YKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLA 2981
                    F++      +++++   +         R       E       LL  G +  
Sbjct: 2103 -------RFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGY-- 2153

Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDL--EAFSPRIERLQQTAALLESRKNPESP 3039
            ERG  L+      S   +  +  R+   +++L  E   PRI+RL +    +E    P +P
Sbjct: 2154 ERG--LEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211

Query: 3040 KVLAQLQAVREAHAELLRRAE 3060
            +  A+  A   A  ++  R E
Sbjct: 2212 EDAAETPATPAAAEQVRPRPE 2232



 Score =  305 bits (780), Expect = 7e-82
 Identities = 450/1974 (22%), Positives = 808/1974 (40%), Gaps = 154/1974 (7%)

Query: 1482 QASVEL--HQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQG 1539
            Q  +EL   +F H   M  SW+ E+    S  ++   L   ++  +KH+ ++ ++ A++ 
Sbjct: 424  QEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEE 483

Query: 1540 QVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLD 1599
            +VQ V    ++LAA G+   + +  Q   +   WA L     AR   L+Q +  Q+ F +
Sbjct: 484  RVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQE 543

Query: 1600 VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA---QT 1656
            +  +  W+EE +  + SR+ G+       L+ KH  L+ ++A     +E L+  A     
Sbjct: 544  MVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQ 603

Query: 1657 LTGPEVPEQQRVVQERLREQ---LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLAS 1713
            L G + P   +V+  R+      L  LQE AA R  ELE +  L   L+E E+ + W   
Sbjct: 604  LQGYQ-PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARD 662

Query: 1714 QK---QAAKGGESLG----EDPEHALHLCTKFAKF--QHQV---EMGSQRVAACRLL--A 1759
            ++   +AA GG + G           H  +  A+   QH++   E+G +R    + L   
Sbjct: 663  KERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCG 722

Query: 1760 ESLLERGHSAGP--------MVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
            E L+  G + GP         + +R    +  W  L E    R   L++     +   DL
Sbjct: 723  EELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADL 782

Query: 1812 LEVLTQVQ-------------EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQ 1858
              +L  ++             ++A+S    +AR    L  ++ +H+G    + G  RQL 
Sbjct: 783  DGLLDWLRDAYRLAAAGDFGHDEASS--RRLARQHRALTGEVEAHRG---PVSGLRRQLA 837

Query: 1859 ELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVR 1918
             L   +G       GP   A+Q R     Q +A +      RR  L  A  + R    V 
Sbjct: 838  TLGGASG------AGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVH 891

Query: 1919 DYASWAARVRQDLQVEESSQEPSS-GPLKLSAHQWLRAELEAREKLWQQA-TQLGQQALL 1976
                W     Q L    S + P S   +++  H++   + E    + +        Q L+
Sbjct: 892  ACELWIGEKEQWLL---SMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV 948

Query: 1977 AAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQ--LFLRECGRLEEILAAQE 2034
              G P+    +E+R+ Q   D +   W R  E ++  ++E   + L E   LE      +
Sbjct: 949  EGGHPS---SDEVRSCQ---DHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQ 1002

Query: 2035 VSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDR 2088
            V  K  A+ S+      L  +       L A + ++AAL E    L      +  R+   
Sbjct: 1003 VREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQG 1062

Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWI---QAWAQQLKEPVPPGD 2145
               L      +   A++ G A+ A+  +  F        DW+   Q  A   + P+ P  
Sbjct: 1063 AEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPL-PNS 1121

Query: 2146 LRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAG---EVSQRLQGLRKHW 2202
            L +    L +H A + EV   EE    +    EALLA      G    + + L  L   W
Sbjct: 1122 LEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGW 1181

Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
              L      R + L     +  FL+ +  A   ++ +E+ ++  +L   +E   +  ++ 
Sbjct: 1182 HKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQH 1241

Query: 2263 REFRGN-SAGDTVGDACIRSISDLSLQ--LKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
            R+F              +++   L  Q  +     +E       ++Q N   A       
Sbjct: 1242 RDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQ------ 1295

Query: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD-CGKDLESVQRLLRKHEELEREV 2378
            ++ Q+L   LE+    R+   +   I EK  ++ A D   +D   + +   +H+    E+
Sbjct: 1296 QWMQKLHDQLELQHFLRDCHELDGWIHEK--MLMARDGTREDNHKLHKRWLRHQAFMAEL 1353

Query: 2379 HPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQ 2438
               +  +E +ERE  +L Q  PE A  +R +  E+ + W +L S  Q +   L    +A 
Sbjct: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKAD 1413

Query: 2439 KLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTG 2498
            +L     EL      + +Q+               L++ Q  +++++ W       R  G
Sbjct: 1414 QLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEW------YREVG 1467

Query: 2499 Q-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKM 2553
            + Q  TA  P     ++++      + + L  L    QE +  L  + EL      ++  
Sbjct: 1468 ELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDE 1527

Query: 2554 ERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHP 2613
              W+  +          + L  ++  + K++ L  +++    ++  +   A  L     P
Sbjct: 1528 LAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP 1587

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLREKNLVALE 2672
            EA+ A+ R    L    A  R+A  RR + L+   Q++ +  D  EV AWL E+ L+ + 
Sbjct: 1588 EAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS 1646

Query: 2673 EGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQRLLQGGHPASEAIQERLEEL 2730
            E          QL K ++ Q E     +++   +L R+ + LL+ GHP SE I  R  ++
Sbjct: 1647 EDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 1705

Query: 2731 GALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGEL 2790
              L+  L++  +++   L++     +L R + ELE+W+   EV   +P +GQ    V  L
Sbjct: 1706 DRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 1765

Query: 2791 LGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQE 2849
                 E  +      R+  A + Q     +  GH  A  + E    L + +  L E +  
Sbjct: 1766 QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGT 1825

Query: 2850 RRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQDYGQSLSAV-RHLQEQHQNLE 2904
            R   L A   L KFF DA E    ++EK   LP L    +   S S++ R L+    +L+
Sbjct: 1826 RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQ 1885

Query: 2905 SEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQ 2964
              +S    L         + V AG   A  +A+R Q++ +    L +     RL +    
Sbjct: 1886 LLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQGWKELLSACEDARLHVSSTA 1942

Query: 2965 EAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQ 3024
            +A +F +++ +  SW+      + + D      + + L+   +  K +LEA  P +   Q
Sbjct: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002

Query: 3025 QTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDA 3084
            +    L   K+  + ++ AQL  +     E+  + +     LQ+ L++HQ  +E ++ DA
Sbjct: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062

Query: 3085 WLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRR 3144
            WLT +    +S++ G  ++ V+ L  + +AFRK   +  + +  +LR+L  T+E+     
Sbjct: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRK-AAAAWEERFSSLRRLT-TIEK----- 2115

Query: 3145 YPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED 3204
               I+A++S+ +     L +        LAA        +AA  L+    E+        
Sbjct: 2116 ---IKAEQSK-QPPTPLLGRKFFGDPTELAA--------KAAPLLRPGGYERGLEPLARR 2163

Query: 3205 GGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAA-PGGLAKVQEAWAT 3263
               +LS+    +  + R E + E ++  + RL       G++ PAA P       E  AT
Sbjct: 2164 ASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIP---GRVEPAALPAAPEDAAETPAT 2220

Query: 3264 LQAKAQERGQWLAQAAQGHA------FLGRCQELLAWAQE--RQELASSEELAEDVAGAE 3315
              A  Q R +   Q +   A           QE +  ++E  R+     +E AE  A   
Sbjct: 2221 PAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHS 2280

Query: 3316 QLLGQHEEL--GQEIRECRLQAQDLRQEGQQL---VDNSHFMSAEVTECLQELE 3364
              LG++E++   +E RE RL+ Q+  ++   +   +       A++ E LQE E
Sbjct: 2281 LTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKE 2334



 Score =  286 bits (733), Expect = 2e-76
 Identities = 484/2193 (22%), Positives = 852/2193 (38%), Gaps = 215/2193 (9%)

Query: 1568 ELEGHWAELERA-----CEARAQCLQQA---VTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
            +++  W ELE+A        RA+ ++Q    +  Q++   V+  E W+ E + LVS  ++
Sbjct: 398  DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF 457

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQL 1677
            G +  A    + KH+A++ ++A Y   ++ + + AQ L      + +RV  +R  +  Q 
Sbjct: 458  GYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQW 517

Query: 1678 RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              L  L   R   LE  L L +  +E   +  W+  + QA       G+    A  L  K
Sbjct: 518  ALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM-EEMQAQLLSRECGQHLVEADDLLQK 576

Query: 1738 FAKFQHQVEMGSQRVAACRLLAE--SLLERGHSAGPMVR-QRQQDLQTAWSELWELTQAR 1794
                +  +   S+RV A    A   S L+      P V   R   +    +EL E    R
Sbjct: 577  HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636

Query: 1795 GHALRDTETTLRVHRDLLEVLTQVQEKATSLPN----------------NVARDLCGLEA 1838
               L  + +   + ++L E  +  ++K   L                    A DL     
Sbjct: 637  RAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTAR 696

Query: 1839 QLRSHQGLERELVGTERQLQELLETAGRVQKL--CPGPQAHAVQ-----QRQQAVTQAWA 1891
             L  H+ L+ EL G    LQ+ L     +       GP A  V      +R  +  + W 
Sbjct: 697  LLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ 756

Query: 1892 VLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQ 1951
             L+    +R  +L+ AR L +F   +     W     +     +   + +S       H+
Sbjct: 757  RLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHR 816

Query: 1952 WLRAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQR--DQVYQTWAR 2005
             L  E+EA       L +Q   LG     A+G     V  ++R ++ ++   +V +  A 
Sbjct: 817  ALTGEVEAHRGPVSGLRRQLATLGG----ASGAGPLVVALQVRVVEAEQLFAEVTEVAAL 872

Query: 2006 KQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTA 2065
            +++ L+          E    E  +  +E  L +  +  S+++VE +  + E   + + +
Sbjct: 873  RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNS 932

Query: 2066 QDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASF 2119
               +   +   ++ L          VR     L  R  R+ EL E R   + A LL+ + 
Sbjct: 933  LMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENH 992

Query: 2120 TQAATQAEDWIQAWAQQLKE-PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
                 +    ++   + ++  P   G L+ +L  L      EA +QA E    ++ ++  
Sbjct: 993  VLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGL------EAALQALEPRQAALLEEA- 1045

Query: 2179 ALLAQSHP-RAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWI- 2236
            ALLA+  P +A  + Q  + L   W  L  A    G+ +        FL  +D    W+ 
Sbjct: 1046 ALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLV 1105

Query: 2237 -QEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPE 2295
              ++    + G L   LE    L  R    +          A I + S+  L     +  
Sbjct: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELG 1165

Query: 2296 EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS---RELDNVTKRIQEKEALI 2352
                + +    L   W   H  L  ++ + E  ++ H+     R+L      ++ +E  +
Sbjct: 1166 PGLALDEWLPHLELGW---HKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMAL 1222

Query: 2353 QALDCGKDLESVQRLLRKHEE----LEREVHPIQAQVESLE---REVGRLCQRSPEAAHG 2405
               +    +ESV+  L++H +    +E     +Q  V++ E   R+     +++ EA   
Sbjct: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTR 1282

Query: 2406 LRHRQQEV---AESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSP 2462
            L  + QE    A+ W Q   +   + E    L    +L   + E ++ A+      D + 
Sbjct: 1283 LLEKNQENQLRAQQWMQ---KLHDQLELQHFLRDCHELDGWIHEKMLMAR------DGTR 1333

Query: 2463 APRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQE 2522
                 +  R +   HQ   AEL    + +      GQQL+      ++ +R+ L  + Q 
Sbjct: 1334 EDNHKLHKRWL--RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQC 1391

Query: 2523 LSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWK 2582
             + LE   Q    QL +A +    + S  ++++ L   E  L        LA +   L K
Sbjct: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 1451

Query: 2583 HKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQ-AMLLRKEALFRQAGTRRH 2641
             + +E  +E    ++  L+A    L     P ++  +G  Q A+  R   L      RR 
Sbjct: 1452 LQSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPLQERRR 1509

Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALE-EGLLDTAMLPAQLQKQQNFQAELDASMH 2700
             L   ++L     D  +  AW++E+  +A++ E       +   ++K Q  + E+ A   
Sbjct: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569

Query: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760
            + +E+      L     P +EA++  LE+L + W  L++ ++++   L  A +  +    
Sbjct: 1570 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 1629

Query: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
            + E+E WL   E+ + +   G+      +LL    +LE  V+        L  Q +A + 
Sbjct: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689

Query: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
             GH  ++ +  +  ++ + + +L+E  +ERR ALE +  L +  R   E   W+ EK  +
Sbjct: 1690 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749

Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESE--MSSHEALTRVVLGTGYKLVQAGHFAAHEVAAR 2938
            A + + GQ    V  LQE+     SE  M+  E L  V      +L++ GH AA  +A  
Sbjct: 1750 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIECGHTAAATMAEW 1808

Query: 2939 VQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDS-EDMGHSAE 2997
               L +A A L      R  LL  ++E  +F ++  E    + E+   L           
Sbjct: 1809 KDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868

Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQL-QAVREAHAELL 3056
            +  ++ R L A + DL+    ++ +LQ+ AA L +    E  + +A   Q V +   ELL
Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928

Query: 3057 RRAE-ARGH--GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFD 3113
               E AR H     + L+ H   R+ L   +W+   A+   + D  +D+  V+VL     
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLL---SWMDGIASQIGAADKPRDVSSVEVLMNYHQ 1985

Query: 3114 AFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL 3173
              + E+++    ++   ++L  +L          IQAQ  ++    E + +      E L
Sbjct: 1986 GLKTELEAR-VPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWL 2044

Query: 3174 AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEV 3233
                EVH F Q A      +  +  L++  + G S+  V  L ++H    +   A E+  
Sbjct: 2045 QQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF 2104

Query: 3234 ARL---------------QTEACRLG--------QLHPAA-----PGGLAKVQEAWA--- 3262
            + L               Q     LG        +L   A     PGG  +  E  A   
Sbjct: 2105 SSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARRA 2164

Query: 3263 --TLQAKAQERGQWLAQAAQGHAF---LGRCQELLAWAQERQELASSEELAEDVA---GA 3314
              TL A+ + R  ++ Q  +       + R  E+    +     A+ E+ AE  A    A
Sbjct: 2165 SDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAA 2224

Query: 3315 EQLLGQHEELGQEIRECRLQAQDL----RQEGQQLVDNSHFMSAEVTECLQELEGRLQEL 3370
            EQ+  + E      +E   +A++L    R E Q+ VD S   +       QE      E 
Sbjct: 2225 EQVRPRPER-----QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESA----EH 2275

Query: 3371 EEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDL 3430
            E A +L   R       +++ +R E+ E  L   E            S+ E+ +    DL
Sbjct: 2276 EAAHSLTLGR------YEQMERRRERRERRLERQES-----------SEQEMPIRG--DL 2316

Query: 3431 EKLLAAQEEKFAQMQKTEMEQEL-----LLQPQELKPGRAGSSLTSFQWRP--------- 3476
             K  A   +   Q+Q+ E    L     L QP+EL PGR  + L   +  P         
Sbjct: 2317 VKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARD 2376

Query: 3477 -----------SGHQGLGAQLAETRDPQDAKG---------TPTMEGSLEFKQHLLPGGR 3516
                        G +G G++ + +   Q             T   EG L  K+ L    R
Sbjct: 2377 RPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKREL-DANR 2435

Query: 3517 QPSSSSWDSCRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTF 3574
            + S+ SW S    L    L  + D +  A         LL L  A  E       +KH F
Sbjct: 2436 KSSNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVF 2495

Query: 3575 SLRLTSGAEILFAAPSEEQAESWWRALGSTAAQ 3607
             L+   G+E L  A  EE+   W  A+ S+ A+
Sbjct: 2496 KLQTQDGSEFLLQAKDEEEMNGWLEAVASSVAE 2528



 Score =  261 bits (666), Expect = 1e-68
 Identities = 423/1983 (21%), Positives = 762/1983 (38%), Gaps = 175/1983 (8%)

Query: 942  ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQVQLRDVLLQLEALQPGSSED 998
            ++ + WG+LE  + E+   L   +   E    L +    +V +R+  L     Q   S+D
Sbjct: 398  DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNEN--QRLVSQD 455

Query: 999  T----CHALQLAQKKTLVLE-------RRVHFLQSVVVKVEEPGYAESQPLQGQVETLQG 1047
                   A++ A KK   +E        RV  +  +   +   GY + + +  Q +++  
Sbjct: 456  NFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLR 515

Query: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
                +   V  R  R  +  A Q   QE   ++ W E +QAQL S+E    +  A  LL+
Sbjct: 516  QWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQ 575

Query: 1108 EHQDLLEEIHLWQERLQQLDAQSQPMAALD----------CPDSQEVPNTLRVLGQQGQE 1157
            +H  L  +I    ER++ L+A +   + L           C     V   L  L +Q   
Sbjct: 576  KHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR 635

Query: 1158 LKV-LWEQRQQW--LQEGLELQKFGREVDGFTATCANHQAWLHLDNLG-----EDVREAL 1209
             +  L   R  W  LQE  E + + R+ +          A       G      D+    
Sbjct: 636  RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695

Query: 1210 SLLQQHREF-GRLLSTLGPRAEALRAHGEKLVQ---SQHPAAHTVR-----EQLQSIQAQ 1260
             LL QH+   G L        +ALR  GE+LV    +  P A TV      E+  S + +
Sbjct: 696  RLLAQHKILQGELGGRRALLQQALRC-GEELVAAGGAVGPGADTVHLVGLAERAASARRR 754

Query: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAA-----HEPSGARRNILQ 1315
            W RL+  + +R R+L  +  L ++  D+  L+ W+ +   +AA     H+ + +RR    
Sbjct: 755  WQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR---- 810

Query: 1316 TLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTE 1375
              ++H A   E+ A R  V  L++    L      G   +  +++ + +  E L  ++TE
Sbjct: 811  LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEA--EQLFAEVTE 868

Query: 1376 ----RGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
                R   L+ A    ++  ++   +  + + E  L S      L   + +Q R + L+ 
Sbjct: 869  VAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQ 928

Query: 1432 ESRTLAAKMA----ALASMAHGMAASPAILEETQKHL-----RRLELLQGHLAIRGLQLQ 1482
            E  +L  ++      +  +  G   S   +   Q HL     R +EL++          Q
Sbjct: 929  EMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVE----------Q 978

Query: 1483 ASVELHQFCHLSNMELSWVAE--HMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQ 1540
               E+     + N  L  VAE          +         +L  +   L+  ++A + +
Sbjct: 979  RKEEMSAVLLVENHVLE-VAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037

Query: 1541 VQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDV 1600
               +L     LA     QA  + +  +EL   W  L  A +A  + +  A   Q++  D+
Sbjct: 1038 QAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDL 1097

Query: 1601 SELEGWVEEKRPLVSSRD----YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQT 1656
                 W+   +      +       +EA    L+ +H AL+EE+         +   ++ 
Sbjct: 1098 DAFLDWLVRAQEAAGGSEGPLPNSLEEADA--LLARHAALKEEVDQREEDYARIVAASEA 1155

Query: 1657 LTGPEVPE--QQRVVQERLREQLRALQELAATRDRELEGTLRLH---EFLREAEDLQGWL 1711
            L   +  E      + E L        +L    +   E  ++ H    FLR+       L
Sbjct: 1156 LLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVL 1215

Query: 1712 ASQKQAAKGGESLG--EDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
             +Q+ A  G E  G  E  E AL    +   F   +E+  Q++      AE LL +G+  
Sbjct: 1216 RNQEMALSGAELPGTVESVEEAL---KQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIY 1272

Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNV 1829
            G   ++    L     E     Q     L D        RD  E+   + EK     +  
Sbjct: 1273 GEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGT 1332

Query: 1830 ARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQA 1889
              D   L  +   HQ    EL   +  L+++     ++ +  P   A +V+++   + Q 
Sbjct: 1333 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQC 1391

Query: 1890 WAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSA 1949
            WA L+   + +  QL  A        A +   S+A   ++ L +E   Q+   G    + 
Sbjct: 1392 WAELESTTQAKARQLFEA------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445

Query: 1950 HQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
            +  L+       ++ +   ++G+     A  P +   +EL  + ++++ V +   R  E 
Sbjct: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEP 1503

Query: 2010 LQAEQQEQLFLRECGRL-----EEILAAQE---VSLKTSALGSSVEEVEQLIRKHEVFLK 2061
            LQ  ++  L  +E  ++     +E+   QE   ++++T   G+ ++ V+Q I+K++   +
Sbjct: 1504 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRR 1562

Query: 2062 VLTAQDKKEAALRER---LKTLRRPR---VRDRLPILLQRRMRVKELAESRGHALHASLL 2115
             + A   +   + ER   L +LR P    VR  L  L      ++E AE R   L A+  
Sbjct: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622

Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
            +  +     + E W+      +       D +  L+ L KH   E  V+ +EE +  +++
Sbjct: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            +  ALL   HP + ++S+R   + + +  L++    R   LE +    +  ++V   E W
Sbjct: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 1742

Query: 2236 IQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPE 2295
            I EKEV     +LGQD EH   L+ +  EF   +     G   + +++ +  +L      
Sbjct: 1743 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG--MAGRERLAAVNQMVDELIECGHT 1800

Query: 2296 EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQAL 2355
                + + +  LN  WA     +    Q L  + E+H    +   +  +I+EK   +  L
Sbjct: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860

Query: 2356 DCGKD----LESVQRLLRKHEELEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQ 2410
                +      S+QR LR     E ++  + +QV  L+    +L    + E A  +  R+
Sbjct: 1861 TTPPEPRPSASSMQRTLR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917

Query: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470
            QEV + W +L S  +  R  + +   A +  + +++LL     + +Q+  +  PR     
Sbjct: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSV 1977

Query: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530
              ++  HQ  K EL++    ++  +  G+ LL      + +I+  L  L      +   W
Sbjct: 1978 EVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKW 2037

Query: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590
              H   LQQ LE+  F       + WL ++E  L S  L   +  +E L+ +H+      
Sbjct: 2038 DRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAA 2097

Query: 2591 EVQAGKISAL-------------------------------EATARG---LHQGGHPEAQ 2616
                 + S+L                               E  A+    L  GG+    
Sbjct: 2098 AAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGL 2157

Query: 2617 SALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL 2676
              L R  +  L  E   R    R+    E  +LQ  +    E+   +    L A  E   
Sbjct: 2158 EPLARRASDTLSAEVRTRVGYVRQELKPE--RLQPRIDRLPEIPGRVEPAALPAAPEDAA 2215

Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736
            +T   PA  + Q   + E   S  + +EL R  +   Q     SE    R         E
Sbjct: 2216 ETPATPAAAE-QVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRP------E 2268

Query: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIE-VELRAPTVGQALPGVGELLGTQR 2795
             Q++++ + A         ++ R  E  E  LE  E  E   P  G  + G   L     
Sbjct: 2269 RQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVE 2328

Query: 2796 ELE 2798
            +L+
Sbjct: 2329 QLQ 2331



 Score =  127 bits (320), Expect = 2e-28
 Identities = 150/634 (23%), Positives = 257/634 (40%), Gaps = 65/634 (10%)

Query: 2854 LEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--------------E 2898
            LE   ++ ++   A E +AW+   + L + Q +  SLS V + LQ              +
Sbjct: 305  LEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQ 364

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            +  NLE  + S ++  R         V        ++     +LEKA  H R  A R  L
Sbjct: 365  EKGNLEVLLFSIQSKLRAC--NRRLFVPREGCGIWDIDKAWGELEKA-EHEREAALRAEL 421

Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
            + Q+  E  AQ+F  ++    SWL E   ++  ++ G+   A +A +++ EA + D+ A+
Sbjct: 422  IRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAY 481

Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
              R++ + + A  L +    +  +V AQ  +V    A L     AR   L++ L L ++ 
Sbjct: 482  EERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVF 541

Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGT 3136
            +E + +  W+    A   S++ GQ L     L +K      ++ +  + +V AL   A  
Sbjct: 542  QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE-RVEALNAAALR 600

Query: 3137 LE--RGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
                +G     P +   R + +      L +    R   L A+  + +  Q   E +   
Sbjct: 601  FSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWA 660

Query: 3194 QEKTALMKGEDGG---------------HSLSSVRTLQQQHRRLERELEAMEKEVARLQT 3238
            ++K  L++   GG               H LSS   L  QH+ L+ EL         L  
Sbjct: 661  RDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRR----ALLQ 716

Query: 3239 EACRLGQLHPAAPGGL----------------AKVQEAWATLQAKAQERGQWLAQAAQGH 3282
            +A R G+   AA G +                A  +  W  L+  A  R + L +A   H
Sbjct: 717  QALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALH 776

Query: 3283 AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
             F      LL W ++   LA++ +   D A + +L  QH  L  E+   R     LR++ 
Sbjct: 777  QFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQL 836

Query: 3343 QQLVDNSHFMSAEVTECLQ----ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
              L   S   +  +   LQ    E E    E+ E  ALR Q   ++  + ++   +   E
Sbjct: 837  ATLGGASG--AGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACE 894

Query: 3399 AWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEK 3432
             W+   E  LL      S+ DVE++ HR + L++
Sbjct: 895  LWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQ 928


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  869 bits (2245), Expect = 0.0
 Identities = 604/2122 (28%), Positives = 1024/2122 (48%), Gaps = 90/2122 (4%)

Query: 5    YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
            +E   I+ L      +Q+KTFTKW+N+     +   +I +LY +L DG  L++LLE++SG
Sbjct: 40   FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97

Query: 65   EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
            E LP P++G++R+H LEN  +AL FL+  +V +  +G  +IVDG+  L+LGLIW IILRF
Sbjct: 98   EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157

Query: 124  QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
            QI  I +  +E        S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH 
Sbjct: 158  QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214

Query: 184  HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
            HRPDL+D+  L+     HNL  AF VAE++LGI  LLDPEDV    PDE+SI+TYV  +Y
Sbjct: 215  HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274

Query: 244  HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
            HY S++       +R+ K++    ETE +  +Y  L +DLL WI +    L +R F +SL
Sbjct: 275  HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334

Query: 304  PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
              ++Q L AF+ +RT EKPP+ Q++G  E LLF +Q+ ++A N++ + PH+G  ++++++
Sbjct: 335  TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394

Query: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
             W  LE AE  R  AL+  L++ ++LE LARRF  KAA+RE++L + ++++ Q       
Sbjct: 395  AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453

Query: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
            LA VEAA ++   +E      E R +AL ++A  L +E YH    +  R++ +   W  L
Sbjct: 454  LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513

Query: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
             + LQ +R+++    A+  L Q++  +   ++E++    S   G+ L EV +LLQ+H L+
Sbjct: 514  QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573

Query: 544  EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            EA ++  G  V  +   T +     G      +V+Q +   L Q  + L  +   R+A L
Sbjct: 574  EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633

Query: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
            EQ+ +  +F    +E E+W+KE  Q   +   G+DL+ +    +KHKA E E+    A  
Sbjct: 634  EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693

Query: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
              + +    + AR+    P    R + V   W  L+         LQ A    Q+  DA 
Sbjct: 694  EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753

Query: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
            +  +WL++    L     GQD+ A   L ++H      L      +  LE+Q +      
Sbjct: 754  DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                                                      P+   D   +      L 
Sbjct: 810  ------------------------------------------PEEFRDSPDVTHRLQALR 827

Query: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899
            + Y+ + A A LR+ RL+EA+ L+         +LW+ EK+  L +   P  DTLE +++
Sbjct: 828  ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885

Query: 900  KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
                F       K L  +   V+ +A  L +     S ++++ Q+ L+ RW   + L  E
Sbjct: 886  VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945

Query: 957  KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016
            +   +  ++ V ++  +C  T   + D    +E+ +     D    + + Q+K   LER 
Sbjct: 946  RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003

Query: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069
            V  +Q+ V  ++ E     +S P Q    GQ +  L+ L + +Q+ +  +     E    
Sbjct: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063

Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128
            Q+FLQ+      W    Q  + S+++   +  A++LL++H  + +EI   Q+  Q++ ++
Sbjct: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123

Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
              + +     P+   +   L  L      L  +WE R   L + L  Q+F ++     A 
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183

Query: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
             +N +  L      + +  A + +++  +F   +     +  +    G KLV   +  + 
Sbjct: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243

Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
             ++E++Q I+ +  +   ++++    L  +L+LQ + Q+  EL  W+ +K L +      
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303

Query: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
              RN+     +H+A  +EL +    +E +   G++L+  +P     +  +L+ L   W+ 
Sbjct: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363

Query: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
            L     E+   L  A   +  L+   D  + +  +E  L+S + G+DL S  R+  + ++
Sbjct: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423

Query: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488
            +E +      ++  L +    M       + + +  R L+LL+  L  R  QL++S    
Sbjct: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481

Query: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
            Q       E  WV E +P      Y   L   Q   +K++ LQ E+  H  +V+ VL  G
Sbjct: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541

Query: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608
            + L  +     Q + E+   L+  W  L  A   R Q L+ A   QQY+LD  E E W+ 
Sbjct: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601

Query: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668
            E+   V S +  +DE   + ++ +H   Q  +  Y  ++++L   AQ L     PE +++
Sbjct: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661

Query: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726
            +  Q ++ +    L+++A  R R+LE    L +  RE +DL+ W+ S+K+       +G+
Sbjct: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720

Query: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785
            D +H   L  KF  F  +   +G +RV       E L++ GHS    + + +  L   W+
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780

Query: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845
            +L EL   R   L  +    R      E+L  + EK   LP +V  D    E+  R H  
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840

Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
             EREL     Q+Q+  + A R+Q    G +A A+Q ++Q V+ AW  L      RR QL 
Sbjct: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900

Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965
                  RF +  RD  SW   + + ++ +E  ++ SS  L +  HQ + AE+E R K + 
Sbjct: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960

Query: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025
               +LG+  L      ++E++E+L+ +  +R ++ + W  + ERL+   +   F R+   
Sbjct: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020

Query: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
             E  L AQE  L +   G +V+ VE+LI++HE F       +K  A+  ER   L +P  
Sbjct: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073

Query: 2086 RDRLPILLQRRMRVKELAESRG 2107
             +     L+ R   +  AE  G
Sbjct: 2074 LE-----LKERQIAERPAEETG 2090



 Score =  502 bits (1293), Expect = e-141
 Identities = 430/1707 (25%), Positives = 753/1707 (44%), Gaps = 66/1707 (3%)

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
            D+  AW  L E    R  ALR+      + ++ LE L +  ++  ++             
Sbjct: 391  DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446

Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
             +N   DL  +EA  + H+ +E +    E +++ L + A  ++K     Q   +  R+  
Sbjct: 447  QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505

Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
            + + W+ LQ  ++ RR +LE    L +    +     W   ++  L   E  +       
Sbjct: 506  ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565

Query: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002
             L  H+ + A++  +    +  T    +     G      + +Q+ +  L+   +++   
Sbjct: 566  LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625

Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062
             A ++ +L+  ++   F  E    E  +  +E    +   G  +  V  L RKH+ F   
Sbjct: 626  AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685

Query: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
            L   D       +EA      K    P++  R+  +  +  ++K+LA      L  +   
Sbjct: 686  LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745

Query: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175
              F   A   + W+Q  A +L      G      + L  KH+ F  E++    VM  + +
Sbjct: 746  FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            + +    +    + +V+ RLQ LR+ ++ +     LR Q L++  +        D  E W
Sbjct: 805  QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863

Query: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            + EKE    +M + D  +DLE  +Q R  + +    +    +    + + S   ++  + 
Sbjct: 864  MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
               EVK   Q +  LN RW +F   +   ++ ++ AL +H    + +  +K I +K  ++
Sbjct: 921  RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977

Query: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
            ++  D G+DL  +  + RK   LER+V  IQA+V++LERE  +L    PE    +  RQ+
Sbjct: 978  ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037

Query: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465
             + E W  L+   Q +    D L +  +LQA LQ+L      L   Q+  A  D    P 
Sbjct: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091

Query: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524
            S  EA ++L++H   K E+D   DS    + +G++++     P    + Q L GL+   +
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151

Query: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584
            +L   W+     L Q L  Q F    ++ E  L ++E +LA     D L   E  + K +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211

Query: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644
                 +E    K+ +   +   L   G+  +     + Q +  R      +A      L 
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271

Query: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704
            +  +LQ FLQ+ QE+  W+ +K L + +    +   L  +  K Q F AEL +     + 
Sbjct: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331

Query: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764
            +  EG++L+      +  + ++LE L  LW ELQ  +++K   L  A  +    ++  +L
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391

Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
              W+  +E +LR+   G+ L  V  +L   + +E  V+ +  +   L  Q  +   EG  
Sbjct: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451

Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884
                +E+       RF  L EPL  R+  LE+    L+  RD ++E  WV+E+LPLA + 
Sbjct: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504

Query: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
            DYG +L  V+   +++Q L++E+  H      VL  G +LV+A      ++  R+  L+ 
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564

Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004
            +   LR  AA R   L+ A EAQQ+  +  EA +W+ E+   + S+++    E    +L+
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624

Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
            R    +R +E +   I++L   A  L S  +PE  +++     V + +A L   AE R  
Sbjct: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684

Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
             L+    L QL+RET  L+ W++ K   A S + GQD + V +L +KF  F +E  ++GQ
Sbjct: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744

Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
             +V  +      L          I   +  +   W  L + I  R + LAA++++H +  
Sbjct: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804

Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243
              AE+ G + EK   +  ED G   S+  +  + H   EREL  +  +V + Q  A RL 
Sbjct: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863

Query: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299
                G+   A      +V  AW  L      R   L   A    F    ++LL+W +   
Sbjct: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923

Query: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359
                ++E   DV+  E L+  H+ +  EI           + G+ L+   H  S E+ E 
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983

Query: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419
            LQ++  R +E+ E W  RW+R      + +  +    AEAWL   E  L   D+GH+V  
Sbjct: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043

Query: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK 3446
            VE L+ RH+  EK  A+  E+FA ++K
Sbjct: 2044 VEKLIKRHEAFEKSTASWAERFAALEK 2070



 Score =  399 bits (1026), Expect = e-110
 Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)

Query: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
            H  KLV   + A  ++ E      A++ R L  R+E  R++ L  L  + + +  A    
Sbjct: 384  HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436

Query: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
            W+ E   + A +  G     ++  K+ HEA E++  A    V AL+ + +EL       Q
Sbjct: 437  WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496

Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
            + I  R   +   W  L   +  R   L+     ++L + +  + + +++++  L S+E 
Sbjct: 497  KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556

Query: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465
            G+ L   + L ++H+ +E++      K+ A+ +               P ++++   HL 
Sbjct: 557  GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616

Query: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
            +  E L    A R  QL+ S  L +F    +   SW+ E     S   Y + L     L 
Sbjct: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676

Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581
            RKHK  + E++     ++++      + A    GHPQ   I  + +E+   W +L+    
Sbjct: 677  RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733

Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
               + LQ A  F Q+  D  +L+ W+++   L+S  D G+DE AT  L  KH+   EEL 
Sbjct: 734  FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793

Query: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694
                 ME L+Q AQ       PE+ R   + +  +L+AL+EL       A  R + L+  
Sbjct: 794  ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847

Query: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
            L L+    E +  + W+  +++  A        ED E   H   +F     +++    ++
Sbjct: 848  LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904

Query: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809
                L A SL+E GH     V+Q Q  L T W     L   R  A+   ++ LRVH    
Sbjct: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961

Query: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
            D  E    + +K   + +  ++ RDL G+ A  R   GLER++   + ++  L   + ++
Sbjct: 962  DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021

Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927
                P  Q   + QRQ+ + + W  LQ+ ++ +   L     L  F   + D+ +W +  
Sbjct: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986
            ++ +  E+  +        L  H  ++ E++  +  +Q+  + G++ +     P    + 
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            + L  L    + + + W  +   L      Q F ++  + E IL+ QE +L       S+
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098
            E  E  IRK E FL        KVL+  D     + E    L   ++++++ ++  R  +
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258

Query: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
              E A+     L  +L + +F Q   +   WI        + V   + R+     LKHQA
Sbjct: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317

Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
            F AE+ +HE  + ++  +G+ L+ +       VSQ+L+ L + W++L+     + Q L  
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377

Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276
             R+    LQ       WI   E ++   D G+DL    ++  +L+  E + N   + +G+
Sbjct: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437

Query: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
              A + S+     D  L ++ R  + ++ + +R+ QL +  A                  
Sbjct: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482

Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
               +SR+L++ T  ++E+  L Q+ D G +L++VQ  ++K++ L+ E+     +VE + +
Sbjct: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539

Query: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448
               +L + +      L  R   +  SW +LR  A  R + L   ++AQ+  L A   E  
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599

Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508
            +  Q L    D    P+    A  ML+ H   +  ++ +  +I    S  Q LL+AGHP 
Sbjct: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657

Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
               I ++   +++  + L+   +E + +L+    L       + +E+W+  KE   +S  
Sbjct: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717

Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625
            +      +   L + K  ++  E  A    ++  + A    L   GH EA +       +
Sbjct: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775

Query: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
                  L     TR   L     L  +     E+   + EK+    E+  LD +   +  
Sbjct: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835

Query: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744
            +    F+ EL     Q Q+ Q    RL        +EAIQ + +E+ A W  L D    +
Sbjct: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895

Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804
              +L    +  R      +L +W+E I  ++      + +  V  L+   + + A ++ +
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955

Query: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864
            ++   A L   ++ ++  H  ++++ E+ ++++ R K + E  + R   L     + +F 
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015

Query: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
            RDA    AW+  + P  A+ D+G ++ +V  L ++H+  E   +S
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060



 Score =  324 bits (831), Expect = 9e-88
 Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)

Query: 872  ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927
            +L  W+E QT+ +   +  A++L  +Q + + F T   V K    +   + E L    + 
Sbjct: 313  DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371

Query: 928  RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979
            R   N+ ++    +     ++++ W  LE  +  + + L + +   E    L      + 
Sbjct: 372  RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431

Query: 980  QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029
             +R+  L   Q    Q     D   A++ A+KK       T   E RV  L+ +  ++E+
Sbjct: 432  AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490

Query: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089
              Y + + +  + + +  L   +QE +  R +R   T A Q   Q+    + W + ++A 
Sbjct: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550

Query: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146
            L S E    +   + LL++H+ +  +I +  ++++ + A +            D Q + +
Sbjct: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610

Query: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206
             +  L Q  +EL  +   R+  L++   L KF  E+D   +     +      + G+D+ 
Sbjct: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670

Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
              L L ++H+ F   L  L    E +      +V  +      +  +++ + AQW +L+ 
Sbjct: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730

Query: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325
             +   ++ L  +    +++ D  +L  W+++   + + E  G      + L K+H+    
Sbjct: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790

Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
            EL  +R  +E L+Q  +           D+  RLQ LR  ++ +  +   R   LQ+A  
Sbjct: 791  ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849

Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
               +  +    +  + + E  L   E    L   + +Q R   L+ E +TL  ++  +  
Sbjct: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909

Query: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
             A+ +  S       +++ Q HL  R +  Q  ++ R   + +++ +H +C        W
Sbjct: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969

Query: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
            + +       T      L G  ++ RK   L+ +V A Q +V  +    + L  S   Q 
Sbjct: 970  ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029

Query: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
            + I ++ + LE  W  L+++ + +   L +    Q +  D+ + + W+   +  V+S D 
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676
                    +L+ +H  +++E+  +  S + + ++ +  + G   PE   + Q  E L   
Sbjct: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149

Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
              AL  +  +R   L   L   EF ++A+  +  L++Q+      E   +  E A     
Sbjct: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            KF  F   +E    +V +       L+  G+     ++++ Q ++    +  E  Q    
Sbjct: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856
             LRD        ++  E+   + +K  +  +    +   L  +   HQ    EL   E  
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328

Query: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
            L E ++  G+ Q +   PQ  A V Q+ +A+ + W  LQ   +++   L  AR       
Sbjct: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386

Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971
               D   W + +   L+ ++  ++ +S    L+  + +  ++  R+    +L+ Q   +G
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446

Query: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
            ++   A  +  K   + L  L  ++ Q+  + A+ Q     E             E +  
Sbjct: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494

Query: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085
             + + L  SA  G++++ V+  ++K++    ++L    + E  L+   + +    +    
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554

Query: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
              +RL  L     R++E A  R   L  +     +   A +AE WI      +     P 
Sbjct: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614

Query: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203
            D    +  L +H   +  V+ +   +  +A + + LL+  HP  GE   RLQG + KH+ 
Sbjct: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673

Query: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263
             L+     R ++LE+  +  +  +  D  E WI EKE+  +  ++GQD +H   LR + R
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733

Query: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323
            +F   +    +G   + +++    +L +    E   I + +  LN  WA     +    Q
Sbjct: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791

Query: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383
             L  + ++H        +   I EK   +   D G D  + +   R H   ERE+H +  
Sbjct: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850

Query: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
            QV+  +    RL    + E A  +++++QEV+ +W  L      RR  L       +  +
Sbjct: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
            M ++LL   + +  Q++T   PR       +++ HQ   AE+++ + + S     G+ LL
Sbjct: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970

Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
               H  S +IR+ L  +      +   W+    +L+  LE+  F       E WL ++E 
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030

Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             LAS      +  +E L+ +H+  E      A + +ALE
Sbjct: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069



 Score =  299 bits (765), Expect = 4e-80
 Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)

Query: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417
            WE+L     R+     +EL +  + EQL R+           L + +  +     G DL 
Sbjct: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455

Query: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472
            + +  +K+H+ +E+++     ++ AL  +A  +          I       LR    LQ 
Sbjct: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515

Query: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532
             L  R  +L+ ++ L +        + W+ E   H     + + L   + L +KHK ++ 
Sbjct: 516  LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575

Query: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589
            ++     +V+ + ++          Q    Q I ++   LE  + EL      R   L+Q
Sbjct: 576  DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635

Query: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
            +    ++F ++ E E W++EK  + SS DYG+D  + L L  KH+A ++EL    + +E+
Sbjct: 636  SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695

Query: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706
            + Q A  +   +     ++ + R++E   Q   L++LAA   + L+      +F  +A+D
Sbjct: 696  IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754

Query: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766
            L+ WL    +   G E +G+D      L  K   F  ++E     +      A+   E  
Sbjct: 755  LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813

Query: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826
              + P V  R Q L+  + ++      R   L++      V  +       + EK   L 
Sbjct: 814  RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872

Query: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
                 D L  LE        L++E+     Q+  +   A  + +    P++  V+Q Q  
Sbjct: 873  EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931

Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
            +   W   Q  + +RR  ++ A  +  +     + + W     + ++  +      +G +
Sbjct: 932  LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991

Query: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001
                KLS  +   A ++AR    ++ +Q   Q + +     +++ +  + L++    + Q
Sbjct: 992  AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048

Query: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061
            +   +++ L    Q Q FL++    +  L+  + ++ +  +  S+ E EQL+++H     
Sbjct: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108

Query: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113
             +         ++E  + + + +  D   +LL +R+         +  + ESR H L   
Sbjct: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167

Query: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173
            L    F + A QAE  +      L    PP  L      + K + F   ++ + + + S 
Sbjct: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229
               G  L+A+ +  + ++ +++Q +    RK+ E  ++A  L    LE  +NFL+  Q +
Sbjct: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286

Query: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289
             L   WI +K +     D+  D      L  +  + +   A     +  + +I     QL
Sbjct: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339

Query: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349
             +  P+   ++ Q+   L+  W           Q L  A    +  +   ++ K I   E
Sbjct: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399

Query: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409
              +++ D GKDL SV R+L K + +E +V+  + ++  L  +V  + +   +A   +  R
Sbjct: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459

Query: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469
              ++ E   + + + +  R  L      +     ++E L  AQ   A   T+        
Sbjct: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512

Query: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529
             +  ++++Q  + E+   T  +      GQQL+ A      D+ + L  L+     L  A
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572

Query: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
                  +L+ A E Q +    ++ E W+  +E  + S+ +         +L +H   +  
Sbjct: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632

Query: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648
            +E     I  L + A+GL   GHPE +  + R Q  + +  A  +  A  R+ +LE +  
Sbjct: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691

Query: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706
            L    +++ ++  W+ EK LVA    +  D   +     K ++F  E  A    +   + 
Sbjct: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751

Query: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766
               +RL+  GH  +  I E  + L  +W +L +    ++  L  + +  R   +  E+  
Sbjct: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811

Query: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814
             ++      P +V L A T      V  A      LLG Q  ++   D   R   A  G+
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869

Query: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874
                       A+ ++ + + +   +++L +    RRT L   +   +FF  A + ++W+
Sbjct: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919

Query: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934
            +  +     Q+  + +S+V  L + HQ + +E+ +        L  G  L+Q  H A+ E
Sbjct: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979

Query: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994
            +  ++QQ+      +  +   R   L+   E  QF  +   A +WL  +   L S D GH
Sbjct: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039

Query: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053
            + ++ + L++R EA ++   +++ R   L++   L L+ R+  E P   A+    +E   
Sbjct: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096

Query: 3054 ELLRRAEARGHGLQEQ 3069
            E    A    H   E+
Sbjct: 2097 ETAGEAPVSHHAATER 2112



 Score =  165 bits (417), Expect = 9e-40
 Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)

Query: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778
            + ++   W  L++   ++   L      Q+  E L  R  R     E WL   +  +   
Sbjct: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448

Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
              G  L  V         +E        +  AL   AQ   +E +   + +  +   +L+
Sbjct: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508

Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  L+E LQ RR  LE    L K F+D    + W+ E      + ++G+ L  V  L +
Sbjct: 509  LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955
            +H+ +E++++      + +     K  +   +   +   +  R+  LE+    L   AA 
Sbjct: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628

Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
            R+  L+Q++   +F  E+ EA SW+ E+  +  S D G    +   L R+ +A + +L  
Sbjct: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688

Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
                +E++ Q A  + +RK    P++ A+++ V     +L   A      LQ+     Q 
Sbjct: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748

Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
            + +   L AWL         +D GQD    + L +K   F +E++       +  ++  G
Sbjct: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808

Query: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
              E  R +P     +QA R   +    + D     R + L  A ++++        +  M
Sbjct: 809  FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864

Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253
             EK   +   +   +L  +  +Q +   L++E++ +  ++  +   A  L +        
Sbjct: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924

Query: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308
            + + Q+     W   Q    ER + +  A + H +   C+E   W  ++ ++  S+++L 
Sbjct: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984

Query: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368
             D+AG   +  +   L +++   + +   L +E QQL+D+      ++ +  + LE   Q
Sbjct: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044

Query: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428
             L+++   +     E   LQ   Q L+  +AWL+  +  +   D   S+ + E LL +H 
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104

Query: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481
             ++  +   ++ + +++++       + + E LL  Q L+    G +     W    H  
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163

Query: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513
            L   L      +DAK    +  + E+   HL P
Sbjct: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196



 Score =  143 bits (361), Expect = 3e-33
 Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909
            A+E   ++ K+   A + + W+++ + +  ++ +  SL+ V + LQ    ++ +E     
Sbjct: 297  AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356

Query: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960
             E     V+L T    ++A +   +  H+    V  + +A      A  R E A R  L+
Sbjct: 357  QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415

Query: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
            +Q    Q A++F  +     +WL+E   ++  ++ G+   A +A  ++ EA + D  A+ 
Sbjct: 416  RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475

Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077
             R+  L+  A  LE     +  ++ A+   +    + L    ++R   L+  L L +L +
Sbjct: 476  ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535

Query: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136
            + L    W+    A   S ++G+ L  V+ L +K      ++   G + K      L  T
Sbjct: 536  DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595

Query: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
              +G     P  IQ + S +E  +E L      R   L  +  +  F     E +  ++E
Sbjct: 596  EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655

Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251
            K  +    D G  L+SV  LQ++H+  E EL  ++  + ++  EA     R    HP   
Sbjct: 656  KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715

Query: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
              + +V   W  L+  A    + L  A     F G   +L AW Q+   L S E++ +D 
Sbjct: 716  ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775

Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
                 L  +H++  +E+ E R   + L Q+ Q   +     S +VT  LQ L    Q++ 
Sbjct: 776  GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834

Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
                LR QR  E+  L  +    +  E W+   E  L + +   ++ D+E++ HR   L+
Sbjct: 835  AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894

Query: 3432 K 3432
            +
Sbjct: 895  Q 895


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score =  643 bits (1658), Expect = 0.0
 Identities = 543/2264 (23%), Positives = 998/2264 (44%), Gaps = 104/2264 (4%)

Query: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218
            K L   R+Q L++    Q F R+ +         +  +  D   +D       LQ+H+ F
Sbjct: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88

Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
               +         L   G  ++   H A+ T+R +L  +  QW  L  +  ++  +LL +
Sbjct: 89   EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148

Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337
             +L ++ ++  ++M W+ +K  +   E  G     ++ L K+ E  ++++ A    V  +
Sbjct: 149  QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208

Query: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397
             Q   +L+  +   +E I+T+   + + W+ L     +R  +L  A + ++  R + +  
Sbjct: 209  NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268

Query: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457
              +++ E  + S + G+DL S Q L ++H+ LE +   L  K+ AL + A  +  S   L
Sbjct: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327

Query: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
              TQ  ++R EL+     IR L      +L  S  L +F        SWV E     +  
Sbjct: 328  SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387

Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
                 + GA++L  +H+E + E+ AH+   +    SG++L A+GH  +  + E+   L  
Sbjct: 388  ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447

Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
              A L    E R Q  +Q +  Q ++ D  +++ W+ ++   + + D G    +   L+ 
Sbjct: 448  ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507

Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689
            KH+  ++ L+     +  LD+ A  L        + V   R  L  +  AL E A  R  
Sbjct: 508  KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567

Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
            +L  +  L +F R++++L+ W+  + + A   +   +DP +      K   F+ ++    
Sbjct: 568  QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625

Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
             R+ A     + L++  H A   V  R  ++ + W +L E T+ +G  LR+     + +R
Sbjct: 626  SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685

Query: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868
            ++ ++   + E    L ++   +DL  ++   + H  LE ++   + ++  +   A + Q
Sbjct: 686  NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745

Query: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928
                   A  ++++Q+A+   +  L+  M  R+ +L  +  L +    V D  +W  R +
Sbjct: 746  D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803

Query: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
            + +    +  +   G   L   HQ L+AE+   E   +  TQ G   +       ++V+ 
Sbjct: 804  EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863

Query: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047
            +L  L  + + +    +++++ L+   Q Q +  +    E  +  +E  + ++  G   +
Sbjct: 864  KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923

Query: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099
              E L++KHE  +  L+A      ALRE+ ++ R+            L + L   +    
Sbjct: 924  SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983

Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159
            +E+   +G  L         T   +  +DW +      +  VP   ++ KL P     A 
Sbjct: 984  REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028

Query: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
             A  +   E   S+A + E +  Q+     AG VS R++ + + +  L +    R   LE
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088

Query: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276
               + F+ F +  +L + WI EKE  +   ++G DLE    L+++  +F+ +   +    
Sbjct: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147

Query: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304
              I  +++  L+ +    EEV+ + Q+                                 
Sbjct: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206

Query: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
               +LN RW S         Q L  A E+    R+ D   + I+EK   +   + G DL 
Sbjct: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266

Query: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422
            SVQ L RKHE  ER++  +  +V SL     RL Q  PE+A  L+ +  E+ ++W  L  
Sbjct: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326

Query: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482
            RA +R+  L   H  Q+  +  ++L+     +R  + +    +    A  +LE HQE + 
Sbjct: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386

Query: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542
            E+D+   +       GQQLL  GH  S +I+Q L  L+QE + LE AW + ++ L Q LE
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446

Query: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602
            LQLF    E+ E W+ ++E  L +E   D L  +E L+ KH+  +  + VQ  KI+AL+A
Sbjct: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506

Query: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
             A  L   GH        R   +L R   L  Q   +R +L E + LQ F +D  E+ AW
Sbjct: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566

Query: 2663 LREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA--S 2720
            + EK   A +E   D   + ++ QK Q F+AEL A+  + + +   G  L++ G  A   
Sbjct: 1567 ISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1626

Query: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTV 2780
            +A++ RL  L   W  L   S +K  KL++A +       +++ + WL  +E  L +   
Sbjct: 1627 DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY 1686

Query: 2781 GQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRF 2840
            G+ L  V  LL   + LEA +     + + L  QA + +         V+++   +  RF
Sbjct: 1687 GKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRF 1746

Query: 2841 KSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQH 2900
            + ++     RR  L     L +FFRD D+E +W++EK  L  ++DYG+ L+ V++L+++H
Sbjct: 1747 QKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKH 1806

Query: 2901 QNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLL 2960
            + LE+E+++HE   + VL TG KL         E+  R+ Q  +    L+  AA R   L
Sbjct: 1807 KRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1866

Query: 2961 QQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRI 3020
            +++ E QQF+  + E  +W+ E+  ++ SED G +  A Q LL++ EA + D      R+
Sbjct: 1867 EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1926

Query: 3021 ERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETL 3080
              +      L  + N     + ++++ +    ++L + A  R   L E     Q   +  
Sbjct: 1927 NDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 1986

Query: 3081 LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERG 3140
            ++++W+  K  + ++ DYG+DL  V+ L  K + F   +Q+  Q  +  +  L   L   
Sbjct: 1987 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2046

Query: 3141 APRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAAELQGR 3192
               +   I+A+ + +   W +L     AR + L  A            +F + A+     
Sbjct: 2047 KHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSW 2106

Query: 3193 MQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACRLGQLH 3247
             +     +      +SL  ++ L++ H      L + + +  +L     Q ++ R+   +
Sbjct: 2107 FENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVAS-N 2165

Query: 3248 PAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAWAQE-R 3298
            P     +  ++E W  LQ   +ER   L +  +           F         W QE R
Sbjct: 2166 PYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETR 2225

Query: 3299 QELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
              L     + E+    E  L   +   QEIR  R Q + +   G
Sbjct: 2226 TYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2269



 Score =  570 bits (1468), Expect = e-161
 Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)

Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142
            +++R   +L R  R KEL+  R   L  S     F + A + E WIQ   Q   +     
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74

Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
            P +L+ KL+   KHQAFEAEVQA+   +  + + G  ++++ H  +  +  RL  L + W
Sbjct: 75   PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
            E L + M  +G +L   +  +++L+  +    WI +KE  +   +LGQDLEH   L+++ 
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
             EF+ + A     +  +  ++  + +L      E ++I  ++ ++N  W    G  L+ Q
Sbjct: 192  EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248

Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
             +L GA E+   +R++D     I+EKE L+ + D G+DL SVQ LLRKHE LER++  ++
Sbjct: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308

Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
             +V++L  E  RL Q  P +A  ++ +++E+  +W Q+R+ A +R   L+  ++ Q+  A
Sbjct: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
              ++L      ++A ++          A  +L+ HQE K E+D+  DS   A  +GQ LL
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
             AGH  S ++R+ L  L +E ++L   W+  + Q +Q ++LQLF    E+++ W+  +E 
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
             L +E L D L  +E LL KH+  E  L  Q  KI+AL+  A  L Q  H   +    R 
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548

Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
             A+L R+ AL  +A  RR +L +   LQ F +DS E+ +W+ EK   A +E   D + L 
Sbjct: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608

Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
             ++QK Q F+AEL A+  +   L++ GQ+L+   H A + +  R+ E+ +LW +L + ++
Sbjct: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668

Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
             K  KL++A +  +  R++E++E WL  +E  L +   G+ L  V  L      LEA V 
Sbjct: 669  LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728

Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
                + + +  QA+ F   GH  A++++++   L+ R+++L+EP+  R+  L     L +
Sbjct: 729  AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788

Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
             FRD ++E  W++EK P+AA+ + G+ L  V++L ++HQ L++E++ HE   + V   G 
Sbjct: 789  LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
             +V+ GHFAA +V A++ +L +    L+A+A++RR  L+ + +AQQ+  +  EA SW+ E
Sbjct: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908

Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
            +  ++ S D G   ++ +ALL++ EA   DL A+   I+ L++ A     +  P   +  
Sbjct: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968

Query: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100
             +L      + E   R     +G  L      ++   +  + D      AA  +  D  Q
Sbjct: 969  KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028

Query: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
                  +LEE+     ++ Q   Q ++        T E G+      +  +  ++E  + 
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074

Query: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220
             L +  + R   L  + +     + A ELQ  + EK A +  E+ G  L  V  LQ++  
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134

Query: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240
              +++L+A                    M +EV  +Q +                    +
Sbjct: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194

Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
             RL     A    + ++ E W +LQ  A+ER Q L  A +   F     E   W +E+ +
Sbjct: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254

Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
              +++    D+A  + L  +HE   +++     +   L +  ++L+  SH  SAE     
Sbjct: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308

Query: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413
             +L+ +  EL +AW+        R  +  +S  LQ+         +W+    GL+   + 
Sbjct: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367

Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462
               V+  E LL RHQ+    + A+   F   +  +  Q+LL       P
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414



 Score =  552 bits (1423), Expect = e-156
 Identities = 462/1933 (23%), Positives = 874/1933 (45%), Gaps = 88/1933 (4%)

Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
            A+ I E+ Q++   +   +     R Q L+ +  FQ +  D  ELE W++EK  + S  +
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676
            Y +D       + KHQA + E+     ++ +LD+T   +   G    E  R     L  Q
Sbjct: 72   Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130

Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
               L E    +  +L    +L ++LRE ED+  W+ + K+A    E LG+D EH   L  
Sbjct: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            KF +FQ  +    +RV      A  L++  H    +++ +Q ++  AW  L  L   R  
Sbjct: 190  KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855
             L       R +RD+ E ++ ++EK   + ++   RDL  ++A LR H+GLER+L   E 
Sbjct: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309

Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
            +++ L   A R+Q+  P        +R++ +T  W  ++    +R A+L  +  L RF  
Sbjct: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
              RD  SW   ++  +  +E + + +     L  HQ  + E++A E  ++ A + GQ  L
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
             A    + EV+E+L  L ++R  + + W  ++++ +     QLF R+  +++  ++ QE 
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089
             L    LG S++ VE L++KHE F K L+AQ++K  AL E    L +        V  R 
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548

Query: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147
              LL RR  + E A  R   L  S  +  F + + + + W+    +   +     P +L+
Sbjct: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608

Query: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207
             K++   KHQAFEAE+ A++  + ++ K G+ L+  +H    EV+ R+  +   W+ L +
Sbjct: 609  GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665

Query: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267
            A  L+G +L +     +F + V+  E W+ E E  +   D G+DL +   L+++      
Sbjct: 666  ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725

Query: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
            + A        I  I+  + Q ++    + + I +++  L  R+ +    ++  +Q+L  
Sbjct: 726  DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782

Query: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387
            +L +  L R++++    I+EKE +  + + GKDL  VQ LL+KH+ L+ E+   + ++++
Sbjct: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842

Query: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
            + ++   + +    AA  ++ +  E+ + W  L+++A +RR+ L+   QAQ+  A   E 
Sbjct: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902

Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
                +     + ++   +    A  +L++H+   ++L ++  SI   R   Q       P
Sbjct: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962

Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
               +      G E  L+  +   +  +    +  ++   L+S  K + W     D     
Sbjct: 963  TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014

Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627
              + P A ++ L         +L  + G I AL             EA S   R + +  
Sbjct: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071

Query: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686
               +L      R+  LE+  +     +++ E+  W+ EK   +  EE   D   +    +
Sbjct: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131

Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726
            K  +FQ +L A+  + +++ +  + L   G  A E  A+Q++                  
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191

Query: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
                            ++EL   W  LQ  ++++   L  A E  R  R  +E + W+E 
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251

Query: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
                L     G  L  V  L     G +R+L A  DK      +L   A+  ++     A
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307

Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886
            +D++E+   L Q + SL +   +R+  L     L +F  D  + M+W+     L ++ + 
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367

Query: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946
             + ++    L E+HQ   +E+ +     +     G +L+  GH+A+ E+  ++  L++  
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427

Query: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006
            A L     +RR++L Q  E Q F  +  +A +W+A R   L++ED G S ++ +AL+++ 
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487

Query: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066
            E   + +     +I  LQ  A  L +  +     + ++   V +    L  +   +   L
Sbjct: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547

Query: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK 3126
             E   L Q  R+   ++AW++ K  TA  + Y +D   ++   +K  AF  E+ +     
Sbjct: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHANADRI 1606

Query: 3127 VYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQA 3185
               +      +ERGA       ++A+ + +   W+ L Q    +++ L  A++  +F   
Sbjct: 1607 RGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTG 1666

Query: 3186 AAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQ 3245
              +    + E  AL+  ED G  L+SV  L ++H+ LE ++ A E  +  L ++A     
Sbjct: 1667 IKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA---DS 1723

Query: 3246 LHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAWAQER 3298
            L  ++    ++V++   T+  + Q+       R   L ++ + H F     +  +W +E+
Sbjct: 1724 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK 1783

Query: 3299 QELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTE 3358
            + L  SE+   D+ G + L  +H+ L  E+       Q +   G++L D++     E+ +
Sbjct: 1784 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ 1843

Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVS 3418
             L +     +EL++  A R QR  ES   Q+    +E+ EAW+     L+   DYG +++
Sbjct: 1844 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA 1903

Query: 3419 DVELLLHRHQDLE 3431
             ++ LL +H+  E
Sbjct: 1904 AIQGLLKKHEAFE 1916



 Score =  531 bits (1367), Expect = e-150
 Identities = 504/2221 (22%), Positives = 949/2221 (42%), Gaps = 142/2221 (6%)

Query: 827  FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884
            F   TI      L + +E L    + +  +L +A  L  +   C ++  W+  +  ++  
Sbjct: 115  FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174

Query: 885  QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944
            + +    + +EV+Q K+E F T +A  +    EV+  A +L Q        I+ +Q+E++
Sbjct: 175  EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234

Query: 945  QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003
              W +L+ L  ++  +L  + EV  F ++   T   +++    + +   G    +  AL 
Sbjct: 235  AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294

Query: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060
               +  ++    LE +V  L +   ++++     +  +Q + E L    +Q++   A+R 
Sbjct: 295  RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354

Query: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120
             R  ++   Q FL + + L  W   ++A + + E++ DVA A+ LL  HQ+   EI   +
Sbjct: 355  ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414

Query: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180
            +  +  D   Q + A     S EV   L VL ++   L  LWE R+Q  ++ ++LQ F R
Sbjct: 415  DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474

Query: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
            + +      +  +A+L  ++LG+ +    +LL++H +F + LS    +  AL     KL+
Sbjct: 475  DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534

Query: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300
            Q+ H A   V  +  ++ ++   L  R+ +RR QL  S  LQ++ +D  EL  W+ EK  
Sbjct: 535  QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594

Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360
             A  E      N+   +++H+A E+EL A +  ++AL++ G++L+      ++++  R+ 
Sbjct: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654

Query: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
             + S W+ L      +G +L++A QQ+Q  R ++D +  L ++EG L S + G+DL + Q
Sbjct: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714

Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475
             LQK+H  LE++      ++  +   A      G   +  I ++ +  + R E L+  + 
Sbjct: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774

Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
             R  +L  S+ L Q       E +W+ E  P  + T+  + L G Q+L +KH+ LQ E+ 
Sbjct: 775  ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834

Query: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595
             H+ +++ V   G ++   GH  A+ +  +  EL   W  L+     R Q L+ ++  QQ
Sbjct: 835  GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894

Query: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655
            YF D +E E W+ EK P+V S DYG+DE +   L+ KH+AL  +L+ Y SS++ L + AQ
Sbjct: 895  YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954

Query: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703
            +      P       E  +E + AL +      RE+  T++  + L             E
Sbjct: 955  SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008

Query: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763
              D QG++ +     K   +     E+ L      A  Q Q++  +      R+  E+  
Sbjct: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059

Query: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823
                     V  R + ++  +  L EL + R   L  +     + R+  E+   + EK  
Sbjct: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112

Query: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881
            +L +  V  DL  +E   +     +++L   E +L+++ + A  ++ +     +  AVQQ
Sbjct: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172

Query: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907
            ++                                  + + + W  LQ+  E+R   L  A
Sbjct: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232

Query: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967
              + RF     +   W     Q L  +    + +S       H+    +L A   L  + 
Sbjct: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289

Query: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019
              LG+ A  L    P     E    LQ++  ++ Q W+       +++ +L      Q F
Sbjct: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344

Query: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079
            L +   L   +      + +  L   V   E L+ +H+     + A+     A  +  + 
Sbjct: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404

Query: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
            L        P ++ +L IL Q R  +++    R   L   L +  F +   QAE+W+ A 
Sbjct: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463

Query: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192
             +        GD  D ++ L+ KH+ F+  +   EE + ++    + L+A  H   G++S
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523

Query: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252
             R   +   W  L+  M  +  +L + +   +F + VD  EAWI EK    +     +  
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTAS----DESY 1579

Query: 2253 EHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRD--PEEVKIICQRRSQLNNR 2310
            +    ++ + ++ +   A        IR + D+   L  R         +  R + L ++
Sbjct: 1580 KDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQ 1639

Query: 2311 WASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRK 2370
            W           Q+L+ A +    +  + +    + E EAL+ + D GKDL SV  LL+K
Sbjct: 1640 WQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 1699

Query: 2371 HEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREA 2430
            H+ LE ++   + +++ L  +   L   S      ++ ++  +   + +++S A  RR  
Sbjct: 1700 HQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK 1759

Query: 2431 LDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
            L+  H+  +    + +     +  +  + +    R     + + ++H+  +AEL +   +
Sbjct: 1760 LNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPA 1819

Query: 2491 ISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSV 2550
            I     TG++L         +I+Q LA   +    L+        +L+++LE Q F+++V
Sbjct: 1820 IQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANV 1879

Query: 2551 EKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQG 2610
            E+ E W+  K   +ASE   D LA ++ LL KH+  E D  V   +++ +    + L + 
Sbjct: 1880 EEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKK 1939

Query: 2611 GHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-NLV 2669
             +   ++   + + +  +   L + A  R+ +L+E      F   +  V +W+ EK N +
Sbjct: 1940 NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSL 1999

Query: 2670 ALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQERLE 2728
              ++   D + +   L KQ+ F A L A   +    +     +LL   H  S+AI+ R  
Sbjct: 2000 KTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHA 2059

Query: 2729 ELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRAPTV 2780
             L   W +L  NS  +  KL +A    R          +      +W E  E +L  P  
Sbjct: 2060 SLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVR 2119

Query: 2781 GQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------AQDV 2829
              +L  +  L    RE   A       A+A   Q     R+                + +
Sbjct: 2120 CNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEAL 2175

Query: 2830 EEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL-----AAA 2883
            EE  R L +  K     LQ E+R   E   L  +F + A+    W+QE            
Sbjct: 2176 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMV 2235

Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
            ++ G   S +   + +HQ + +  S  + +  +       L+    +  H      QQ +
Sbjct: 2236 EESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWD 2295

Query: 2944 K 2944
            +
Sbjct: 2296 Q 2296



 Score =  512 bits (1318), Expect = e-144
 Identities = 547/2416 (22%), Positives = 1014/2416 (41%), Gaps = 213/2416 (8%)

Query: 571  SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630
            + E +Q + + +         L   RR  LE + +   F R+ EE E W++E  Q + + 
Sbjct: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69

Query: 631  ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
               +D + + G LQKH+A EAEV  +    V L   G  + +           R   +  
Sbjct: 70   ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129

Query: 691  GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750
             W+LL  ++  +G +L  A  ++QY  +  +   W+ ++ + +     GQD    E L +
Sbjct: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189

Query: 751  RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810
            +    E      AA   R+ E  + A+                                 
Sbjct: 190  K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213

Query: 811  PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870
                 K+     P+ +     I   QD ++  ++ L+ LA  R+ +L  A  +  F    
Sbjct: 214  -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264

Query: 871  GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928
             E   W++++  L+       D   V  L  K+E     LA  +     + + A++L+Q 
Sbjct: 265  DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324

Query: 929  YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988
            +P ++TQIQ ++EEL   W Q+  L  E+  +L  S  +  FL +       + ++   +
Sbjct: 325  HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384

Query: 989  EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041
             A +  S      AL L + +    E   H  +      +E G A        S  ++ +
Sbjct: 385  NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441

Query: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101
            +  L      + E    R ++  +    Q F ++++Q+  W    +A L ++++   + S
Sbjct: 442  LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501

Query: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161
             + LL++H+D  + +   +E++  LD  +  +   +    ++V      L  +   L   
Sbjct: 502  VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561

Query: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221
              +R+  L +   LQ+F R+ D   +   N +     D   +D       +Q+H+ F   
Sbjct: 562  AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620

Query: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
            LS    R +AL   G+KL+   H A   V  ++  + + W +L   +E +  +L  + Q 
Sbjct: 621  LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680

Query: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
            Q++ ++V ++  W+ E +G +A+ +      N+    K+H   E+++ A +  ++ +   
Sbjct: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740

Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
             R+         E+I+ + + L +++EAL   M  R  +L  + + +QL R ++D +  +
Sbjct: 741  ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800

Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455
             + E    S+  G+DL   Q L K+HQ L++E      R  A      A +  G  A+  
Sbjct: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860

Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
            +  +  +  ++ E L+   + R   L+ S++  Q+   +N   SW+ E  P    T Y +
Sbjct: 861  VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574
              + A++L +KH+ L  ++ A+   +Q +             QAQ   +Q    +     
Sbjct: 921  DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969

Query: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
            EL  A     +   + VT ++      L+ +  + W  E    V+ R  G   AA ++ +
Sbjct: 970  ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681
            +  Q+   E     + +EE  Q +  L   ++  Q R+ +E         ++ E   +L 
Sbjct: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077

Query: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741
            EL   R   LE + +     REA +LQ W+ ++K+AA   E +G D E    L  KF  F
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136

Query: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779
            Q  ++    R+     +AE L   G  A  +   +QQ+                      
Sbjct: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196

Query: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
                          L   W  L +L + R   L       R HRD  E    ++EK  +L
Sbjct: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256

Query: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884
              +N   DL  ++A  R H+G ER+L     ++  L ETA R+ +  P   A  +Q++  
Sbjct: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315

Query: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944
             + QAW+ L +R +QR+A+L  +  L RF +  RD  SW   +R  +  +E +++ +   
Sbjct: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375

Query: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004
              L  HQ  R E++AR   +Q   Q GQQ L      + E++++L  L  +R  + + W 
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435

Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
            +++  L    + QLF R+C + E  +AA+E  L T   G S++ VE LI+KHE F K + 
Sbjct: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495

Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
             Q++K AAL+     L       +  +  R   +L R  R+K     +   L  S  +  
Sbjct: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555

Query: 2119 FTQAATQAEDWIQAWAQQLKEP--VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
            F++   + E WI    Q   +     P +++ K +   KHQAFEAE+ A+ + +  V   
Sbjct: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQ---KHQAFEAELHANADRIRGVIDM 1612

Query: 2177 GEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEA 2234
            G +L+ +      E  V  RL  L   W+ L Q  A + Q+L++      F   +   + 
Sbjct: 1613 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1672

Query: 2235 WIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            W+ E E  +   D G+DL     L  + +L E   ++  D + D  + S +D  +     
Sbjct: 1673 WLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSSAF 1730

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
            D  +VK    +R  +N R+          + +L  +  +H   R++D+    I+EK+ L+
Sbjct: 1731 DTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLV 1787

Query: 2353 QALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQE 2412
             + D G+DL  VQ L +KH+ LE E+   +  ++ +     +L   +      ++ R  +
Sbjct: 1788 GSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQ 1847

Query: 2413 VAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARR 2472
              E W +L+  A  R + L+   + Q+  A ++E           + +     +    + 
Sbjct: 1848 FVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQG 1907

Query: 2473 MLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE 2532
            +L++H+  + +     D ++   + GQ L+   +    +I   + GL  ++S LE A  +
Sbjct: 1908 LLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQ 1967

Query: 2533 HQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEV 2592
             + +L +      F    + +E W+  KE+SL ++     L+ ++ LL K +  +  L+ 
Sbjct: 1968 RKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 2027

Query: 2593 -QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ--- 2648
             Q   I+ + A    L    H ++++   R  +++ R   L   +  R+ +L E +    
Sbjct: 2028 FQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFR 2087

Query: 2649 -----LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL-- 2695
                    F + +    +W         EE L D         + A  +    F++ L  
Sbjct: 2088 KVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 2142

Query: 2696 -DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-- 2752
              A  +Q  EL R+ +      +P +    E LEE    W  LQ   +++  +LQK    
Sbjct: 2143 AQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQRR 2199

Query: 2753 --EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLGTQ 2794
              E  +LR+   +  N    W++     L         + T+   L        E+   +
Sbjct: 2200 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2259

Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT-- 2852
             +L+   D  A   EAL+   +        LAQ  ++  +  ++   +L + +Q R T  
Sbjct: 2260 SQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTG 2319

Query: 2853 ----ALEARSLLLKFF 2864
                AL+  S++ K F
Sbjct: 2320 VTEEALKEFSMMFKHF 2335



 Score =  480 bits (1235), Expect = e-134
 Identities = 505/2349 (21%), Positives = 983/2349 (41%), Gaps = 163/2349 (6%)

Query: 936  IQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGS 995
            IQ +++++  R+ + + L   +  +L  S     F ++    +  ++      E LQ  S
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQ------EKLQIAS 68

Query: 996  SEDTCHALQLAQK--KTLVLERRVHFLQSVVVKVEEPG-------YAESQPLQGQVETLQ 1046
             E+      L  K  K    E  V      +VK++E G       +  S+ ++ ++  L 
Sbjct: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128

Query: 1047 GLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLL 1106
               + + E++ ++  +  + Q    +L+E + ++ W    +A + S+E+  D+   + L 
Sbjct: 129  RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
            ++ ++   ++   +ER+ +++  +  +     P+ + +      +    Q LK L  QRQ
Sbjct: 189  KKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248

Query: 1167 QWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLG 1226
              L    E+Q+F R+VD   +     +  +  D+ G D+    +LL++H    R L+ L 
Sbjct: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308

Query: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
             + +AL A  ++L QS   +A  ++ + + +   W +++  + +R  +L  S +LQ +  
Sbjct: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 1287 DVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
            D  +L  W+ E K L+ A E +         L RH+  + E+ A     ++  + G+ LL
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEG 1405
            +      ++++ +L  L  +  AL      R  + +Q    +   R  +     + + E 
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 1406 ALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA-----HGMAASPAILEET 1460
             L + + G  L S + L K+H+  E        K+ AL   A     +   A   +    
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548

Query: 1461 QKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGA 1520
               L R   L      R  QL  S  L QF   S+   SWV E M   +  +Y +  N  
Sbjct: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN-L 607

Query: 1521 QSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERAC 1580
            Q   +KH+  + E+ A+Q ++  +  +G+ L    H     +  +  E+   W +L  A 
Sbjct: 608  QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667

Query: 1581 EARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEEL 1640
            E +   L++A   QQ+  +V ++E W+ E    ++S DYG+D      L  KH  L+ ++
Sbjct: 668  ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727

Query: 1641 AIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
            A +   ++ +   A+     G    E  +  QE L  +  AL+E    R ++L  +LRL 
Sbjct: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787

Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
            +  R+ ED + W+  +K+      + G+D     +L  K    Q ++     R+ A    
Sbjct: 788  QLFRDVEDEETWI-REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846

Query: 1759 AESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQV 1818
              +++E GH A   V+ +  +L   W  L      R   L D+    +   D  E  + +
Sbjct: 847  GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906

Query: 1819 QEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
            +EK   +   +  +D    EA L+ H+ L  +L      +Q L E A    + C    A 
Sbjct: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA----QSCRQQVAP 962

Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESS 1937
               +  + +  A    Q +   R   +++  +L    +  +D+  W   V      +   
Sbjct: 963  TDDETGKELVLALYDYQEK-SPREVTMKKGDILTLLNSTNKDW--WKVEVN-----DRQG 1014

Query: 1938 QEPSSGPLKLSAHQWLRAELEAREKLWQQ--ATQLGQQALLAAGTPTKE---VQEELRAL 1992
              P++   KL       A+  +RE L ++  +  L Q+ +      TKE   V   ++ +
Sbjct: 1015 FVPAAYVKKLDP-----AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069

Query: 1993 QDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQL 2052
            ++    + +   +++  L+   ++ +  RE   L++ +  +E +L +  +G+ +E+VE L
Sbjct: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVL 1129

Query: 2053 IRKHEVFLKVLTAQDKK-------------EAALRERLKTLRRPRVRDRLP--------- 2090
             +K + F K L A + +             E  + E ++ +++  V   +P         
Sbjct: 1130 QKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTA 1189

Query: 2091 --------------------ILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWI 2130
                                 L +R   +++LAE R   L ++  +  F + A + ++WI
Sbjct: 1190 SPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWI 1249

Query: 2131 QAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE 2190
            +   Q L       DL        KH+ FE ++ A  + + S+ +  E L+ QSHP + E
Sbjct: 1250 EEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE 1308

Query: 2191 -VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
             + ++   L + W  L +    R  +L D  +   FL       +WI      ++  +L 
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368

Query: 2250 QDLEHCLQLRRRLREFRGN--------SAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301
            +D+     L  R +E R           A +  G   +      S ++K    +++ I+ 
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK----QKLDILD 1424

Query: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361
            Q R+ L   W       ++ +  L+  LE+ +  R+ +     +  +EA +   D G  L
Sbjct: 1425 QERADLEKAW-------VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477

Query: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421
            +SV+ L++KHE+ ++ ++  + ++ +L+    +L      A   +  R+ EV + W +L+
Sbjct: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537

Query: 2422 SRAQKRREALDALHQAQKLQAMLQELLV-SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
            ++  ++R  L      Q+    + E+    +++L+   D S   + P   +   ++HQ  
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDES--YKDPTNIQSKHQKHQAF 1595

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQ 2538
            +AEL +  D I      G  L+  G    S+  ++  LA L  +   L     E   +L+
Sbjct: 1596 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1655

Query: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKIS 2598
            +A + Q F + ++  + WL   E  LASE     LA +  LL KH++LE D+     ++ 
Sbjct: 1656 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLK 1715

Query: 2599 ALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658
             L + A  L      +      +   +  R + +   A +RR +L E  +L  F +D  +
Sbjct: 1716 DLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDD 1775

Query: 2659 VAAWLREKN-LVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
              +W++EK  LV  E+   D   +    +K +  +AEL A     Q +   G++L     
Sbjct: 1776 EESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT 1835

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
               E IQ+RL +    W EL+  +  +  +L+++ E  +   ++EE E W+      + +
Sbjct: 1836 IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS 1895

Query: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLL 2837
               G  L  +  LL      E        +   +    Q  +++ +   +++  + + L 
Sbjct: 1896 EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLN 1955

Query: 2838 QRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQ 2897
             +   L +   +R+  L+  S  L+F   AD   +W+ EK       DYG+ LS+V+ L 
Sbjct: 1956 GKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLL 2015

Query: 2898 EQHQNLESEMSS--HEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
             + +  ++ + +   E +  +      +L+ A H  +  + AR   L K  + L A +A 
Sbjct: 2016 TKQETFDAGLQAFQQEGIANIT-ALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2074

Query: 2956 RRLLLQQAQE-----AQQFLTELLEA---GSWLAERGHVLDSEDMGHSAEATQALLRRLE 3007
            R+  L +AQ         FLT   +A    SW       L      +S E  +AL    +
Sbjct: 2075 RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHD 2134

Query: 3008 ATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQ 3067
            A +  L +      +L +    ++S +   +P     ++A+ E    L +  + R   LQ
Sbjct: 2135 AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQ 2194

Query: 3068 EQLQ------------------LHQLERET---LLLDAWLTTKAATAESQDYGQDLEGVK 3106
            ++ +                   HQ  +ET   LL  + +  ++ T ESQ     LE  K
Sbjct: 2195 KEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQ-----LEATK 2249

Query: 3107 VLEEKFDAFR---KEVQSLGQAKVYAL---RKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
               ++  A R   K+++ LG A   AL    K       G  +++  +     R++    
Sbjct: 2250 RKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQ---H 2306

Query: 3161 RLDQAIKAR 3169
             L+Q I+AR
Sbjct: 2307 NLEQQIQAR 2315



 Score =  478 bits (1229), Expect = e-134
 Identities = 447/1913 (23%), Positives = 796/1913 (41%), Gaps = 172/1913 (8%)

Query: 244  HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293
            HY S  + +  TV       LL+L E  L + QYEQ +   L          W+++++  
Sbjct: 432  HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489

Query: 294  LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349
            L   D  DSL ++  LL     F      QE+        A + +            RR 
Sbjct: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549

Query: 350  FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409
             L                L    A   +A+++R  QL     L + F+    L+    + 
Sbjct: 550  AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592

Query: 410  AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469
             +   D+A   P++L   +  VQ+    EA +   + R  AL +    L    +++  +V
Sbjct: 593  MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649

Query: 470  ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527
            A R  EV   W++LL+   L+G + + A+ Q   +  + VE     L E++    S   G
Sbjct: 650  AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707

Query: 528  QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587
            + L  V  L ++H LLEA V+AH   +  +  Q  +   +     E ++ K   L    +
Sbjct: 708  KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767

Query: 588  SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647
            +L   + AR+  L  +L+  +  R+ E+EE W++E      +   G+DL  +   L+KH+
Sbjct: 768  ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827

Query: 648  ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707
            AL+AE+  H+     + ++G  +         D   +   +   W+ L+ +   R   L+
Sbjct: 828  ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887

Query: 708  TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767
             +L   QYFADA EA SW+RE+   +     G+D+ +AE LL++H  L   L A+ + ++
Sbjct: 888  DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947

Query: 768  RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816
             L EQ ++   + +           L   +     P E     G       +    D WK
Sbjct: 948  ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006

Query: 817  MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857
            +        +PA      DP        +L+ Q  ++   E +    ++ +       R+
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066

Query: 858  EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894
            ++   L+      GE                     LQ W+ ++   L  + V    + +
Sbjct: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126

Query: 895  EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941
            EV+Q K+++F   L   +    +++  AE L  +       Q  +QQE            
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186

Query: 942  -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
                                   EL++RW  L+ L  E++  L  + EV  F ++   T+
Sbjct: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246

Query: 979  VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034
              + +    L     G    +  ALQ      ++    L  +V+ L     ++ +     
Sbjct: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306

Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094
            ++ LQ +   L      + ++  QR  +  ++   Q FL + + L+ W   ++  + S E
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366

Query: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154
            ++ DV  A+ LL  HQ+   EI       Q  +   Q + A     S E+   L +L Q+
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426

Query: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214
              +L+  W QR+  L + LELQ F R+ +      A  +A+L+ ++ G+ +    +L+++
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486

Query: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274
            H +F + ++    +  AL+A  ++L+ + H A   +  +   +  +W RL+ +  ++R +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546

Query: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHV 1334
            L  S  LQ++ +DV E+  W+ EK   A+ E      NI    ++H+A E+EL A    +
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRI 1606

Query: 1335 EALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQ 1392
              +  +G  L+ R  C G ED ++ RL  L  +W+ L +K  E+  +L++A +Q+     
Sbjct: 1607 RGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTG 1666

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
            ++D    L ++E  L S + G+DL S   L K+HQ LE++      ++  L S A  +  
Sbjct: 1667 IKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT 1726

Query: 1453 SPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPH 1507
            S A      K  R     R + ++   A R  +L  S  LHQF    + E SW+ E    
Sbjct: 1727 SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLL 1786

Query: 1508 GSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQ 1567
                 Y   L G Q+L +KHK L+ E+ AH+  +Q VL +G+ L+       + I ++  
Sbjct: 1787 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1846

Query: 1568 ELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATL 1627
            +   HW EL++   AR Q L++++ +QQ+  +V E E W+ EK  LV+S DYG   AA  
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906

Query: 1628 RLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAA 1685
             L+ KH+A + +  ++   + ++    Q L       ++ +  +   L  ++  L++ AA
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966

Query: 1686 TRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQV 1745
             R  +L+      +F  +A+ ++ W+  ++ + K  +  G D      L TK   F   +
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGL 2025

Query: 1746 EMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
            +   Q  +A    L + LL   H     +  R   L   WS+L   + AR   L + ++ 
Sbjct: 2026 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2085

Query: 1805 LRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLERELVGTER 1855
             R   DL     +      S   N   DL           ++A   +H      L   + 
Sbjct: 2086 FRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQA 2145

Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RAQLERA 1907
               +L E   +++        +      +A+ + W  LQ+ +++R        R Q E  
Sbjct: 2146 DFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRRQEEND 2204

Query: 1908 RLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
            +L   F      +  W    R  L      VEES    S        HQ +RA     +K
Sbjct: 2205 KLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKK 2264

Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
            +      + +  +L      K  +     L  Q DQ+ Q   R Q  L+ + Q
Sbjct: 2265 IEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2313



 Score =  466 bits (1200), Expect = e-130
 Identities = 440/2060 (21%), Positives = 868/2060 (42%), Gaps = 91/2060 (4%)

Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
            I E  Q+ L R    +    +R  +L+ S     F   +     W+ E +   S  +Y +
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
              N  Q   +KH+  + EV+A+ G + ++  +G  + + GH  ++ I  +  EL   W  
Sbjct: 75   PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133

Query: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
            L      +   L QA    QY  +  ++  W+ +K  +V+S + G+D      L  K + 
Sbjct: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193

Query: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693
             Q ++A +   + E++Q A  L   + PE++  +  Q+ +    + L+ LA  R  +L G
Sbjct: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
               +  F R+ ++   W+  +K+     +  G D      L  K    +  +     +V 
Sbjct: 254  AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312

Query: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
            A    A+ L +    +   ++ ++++L T W ++  L   R   L D+    R   D  +
Sbjct: 313  ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372

Query: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872
            + + V E KA    + +A D+ G EA L  HQ  + E+   E   +   E+   +  L  
Sbjct: 373  LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430

Query: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
            G  A   V+++   +++  A L    E RR Q E+   L  F        +W ++    L
Sbjct: 431  GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490

Query: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
              E+      S    L  H+     L A+E+      +   + +       ++V     A
Sbjct: 491  LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550

Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
            L  +R+ +++   R++ +L      Q F R+   L+  +  +++   T         ++ 
Sbjct: 551  LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609

Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
             ++KH+ F   L+A   +  AL +  + L       +  V  R+  ++    ++ E  E 
Sbjct: 610  KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669

Query: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
            +G  L  +     F +     E W+      L       DL +      KH   EA+V A
Sbjct: 670  KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729

Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
            H++ +  +  +        H  A  + ++ + L   +E L++ M  R Q+L D     + 
Sbjct: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789

Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
             + V+  E WI+EKE      + G+DL     L ++ +  +   AG       +    + 
Sbjct: 790  FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849

Query: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345
             ++  +   E+VK    +  +LN +W +      + +Q LE +L+      + +     +
Sbjct: 850  MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906

Query: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405
            +EKE ++ + D GKD +S + LL+KHE L  ++    + +++L RE  + C++       
Sbjct: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965

Query: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458
               ++  +A   +Q +S  +   K+ + L  L+   K    ++   ++  V A  ++ ++
Sbjct: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024

Query: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518
            D    P        +LEE        +   +   + +  G   L         ++QV   
Sbjct: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069

Query: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
             E+   SL    ++ +  L+++ +  +      ++++W+  KE +L SE +   L  +E 
Sbjct: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128

Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617
            L  K    + DL+    ++  +   A  L   G                       ++++
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188

Query: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
            A     A L+               R  +L + A  R   L    ++Q F +D+ E   W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248

Query: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721
            + EKN     +    D A + A  +K + F+ +L A   +   L    +RL+Q    ++E
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308

Query: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781
             +QE+  EL   W  L   + ++ AKL  + +  R      +L +W+  I   + +  + 
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368

Query: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
            + + G   LL   +E    +D +A   +A     Q  +  GH  + +++++   L Q   
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428

Query: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
             L +   +RR  L+    L  F RD ++   W+  +      +D G SL +V  L ++H+
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488

Query: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
            + +  ++  E     +     +L+ AGH+A  ++++R  ++      L+A+   +R  L 
Sbjct: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548

Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
            ++Q  QQF  ++ E  +W++E+      E         Q+  ++ +A + +L A + RI 
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNI-QSKHQKHQAFEAELHANADRIR 1607

Query: 3022 RLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERET 3079
             +      L  R      +  V A+L A+ +    L++++  +   L+E  +        
Sbjct: 1608 GVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGI 1667

Query: 3080 LLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER 3139
               D WL+   A   S+DYG+DL  V  L +K      ++ S  + ++  L   A +L  
Sbjct: 1668 KDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQADSLMT 1726

Query: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTAL 3199
             +      ++ +R  I   ++++     +R   L  +H +H F +   + +  ++EK  L
Sbjct: 1727 SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLL 1786

Query: 3200 MKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG----LA 3255
            +  ED G  L+ V+ L+++H+RLE EL A E  +  +     +L   +          LA
Sbjct: 1787 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1846

Query: 3256 KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAE 3315
            +  E W  L+  A  RGQ L ++ +   F+   +E  AW  E+  L +SE+  + +A  +
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906

Query: 3316 QLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWA 3375
             LL +HE    +    + +  D+   GQ L+  ++     ++  ++ L G++ +LE+A A
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966

Query: 3376 LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEK-LL 3434
             R  +  E+    +   + +  E+W+   E  L   DYG  +S V+ LL + +  +  L 
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2026

Query: 3435 AAQEEKFAQMQKTEMEQELL 3454
            A Q+E  A +  T ++ +LL
Sbjct: 2027 AFQQEGIANI--TALKDQLL 2044



 Score =  454 bits (1168), Expect = e-127
 Identities = 487/2267 (21%), Positives = 922/2267 (40%), Gaps = 175/2267 (7%)

Query: 368  LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414
            LE AE    R Q +  R  + + L TL R+          FQ  A   E ++++  Q+  
Sbjct: 9    LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68

Query: 415  DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474
            D+    P +L   +  +Q+    EA +    G    L E  +++  E + +   +  R  
Sbjct: 69   DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125

Query: 475  EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534
            E+  +W+ LL+ ++ +  ++   Q ++  L+E E     + + +    S   GQ L  V 
Sbjct: 126  ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185

Query: 535  ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594
             L ++ +  +  ++AH   V+ + Q  A+L        E+++ K   +    Q L  L  
Sbjct: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245

Query: 595  ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653
             R+  L    +   F R+ +E  +W+KE  Q + +   GRDL+ +   L+KH+ LE ++ 
Sbjct: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305

Query: 654  ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710
                + +A+C +  R    L    P +      + E +   W+ ++T    R ARL  + 
Sbjct: 306  ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361

Query: 711  LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
             + ++ AD  +  SW+ E ++ +       D A AE LL RH   +  + A     +  +
Sbjct: 362  RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421

Query: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
            E G+A  A                                                +  +
Sbjct: 422  ESGQALLAAG---------------------------------------------HYASD 436

Query: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888
             + +    LS++  +L  L +LRR + E+ M L  F     ++  W+ KQ   L  + + 
Sbjct: 437  EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496

Query: 889  PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948
               D++E +  K+E+F  +L+  +     +   A +L Q        +  +++ L  R  
Sbjct: 497  DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556

Query: 949  QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005
             L      +  QLA S  +  F ++    +  + + +     EA + P + +      Q 
Sbjct: 557  ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616

Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065
             + +    + R+  L+    K+ +  +     +  ++  +  L K++ E    +  +  E
Sbjct: 617  FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676

Query: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               +Q F +  + + LW   V+  L S +   D+ + Q L ++H  L  ++   Q+R+  
Sbjct: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
            +  Q++        D++ +      L  + + LK     R+Q L + L LQ+  R+V+  
Sbjct: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796

Query: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245
                   +      N G+D+    +LL++H+     ++   PR +A+   G  +V+  H 
Sbjct: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856

Query: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305
            AA  V+ +L  +  +W  L+ ++ QRR+ L  SLQ Q++  D  E   WM EK  +    
Sbjct: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916

Query: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363
              G   +  +  LK+HEA  S+L A    ++AL++  +    +  P   E  +  +  L 
Sbjct: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976

Query: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415
               E   R++T ++GD L       +   +++    Q       +++L+ A QS+     
Sbjct: 977  DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035

Query: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475
            L     +  R +Q+++++R      +    M        ++LE  +K             
Sbjct: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082

Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
             R   L+ S +       +N    W+ E     +       L   + L +K  + Q ++K
Sbjct: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141

Query: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565
            A++ +++ +      L + G    + Q + +Q                            
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201

Query: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
                   +EL   W  L++  E R+Q L  A   Q++  D  E + W+EEK   +++ +Y
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D A+   L  KH+  + +LA     +  L +TA+ L     PE    +QE+  E  +A
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320

Query: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
               L   A  R  +L  +  L  FL +  DL  W+   +      E L +D   A  L  
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            +  + + +++  +    A     + LL  GH A P ++Q+   L    ++L +    R  
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855
             L         HRD  +    +  +   L      D L  +EA ++ H+  ++ +   E 
Sbjct: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499

Query: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914
            ++  L   A   Q +  G  A   +  R+  V   W  L+ +M ++R++L  ++ L +F 
Sbjct: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557

Query: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQA 1974
              V +  +W +   Q    +ES ++P++   K   HQ   AEL A     +    +G   
Sbjct: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSL 1616

Query: 1975 LLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAA 2032
            +        E  V+  L AL DQ   + Q  A K ++L+   ++Q F       +  L+ 
Sbjct: 1617 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE 1676

Query: 2033 QEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------RPRVR 2086
             E  L +   G  +  V  L++KH++    ++A + +   L  +  +L         +V+
Sbjct: 1677 VEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVK 1736

Query: 2087 DRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
            D+   +  R  ++K +A SR   L+ S  +  F +     E WI+     +       DL
Sbjct: 1737 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1796

Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
                    KH+  EAE+ AHE  +  V   G+ L   +     E+ QRL    +HW++L+
Sbjct: 1797 TGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELK 1856

Query: 2207 QAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
            Q  A RGQ LE+   + +F+  V+  EAWI EK   +   D G  L     L ++   F 
Sbjct: 1857 QLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFE 1916

Query: 2267 GNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQ 2324
             +     D V D C    +   L  KN   EE   I  +   LN + +       + + +
Sbjct: 1917 TDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAAQRKAK 1971

Query: 2325 LEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ 2384
            L+        + + D V   I EKE  ++  D G+DL SVQ LL K E  +  +   Q +
Sbjct: 1972 LDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE 2031

Query: 2385 -VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQAQKLQA 2442
             + ++     +L       +  +  R   + + W Q L + A ++++ L+A    +K++ 
Sbjct: 2032 GIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2091

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
            +       A    +  + +    +       LEE +  +   D++  S+S A++   QL 
Sbjct: 2092 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2151

Query: 2503 ----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
                       A +P++      +  LE+   +L+   +E +L+LQ+
Sbjct: 2152 ELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2195



 Score =  422 bits (1086), Expect = e-117
 Identities = 399/1844 (21%), Positives = 810/1844 (43%), Gaps = 93/1844 (5%)

Query: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714
            +G +V E    +QER ++ L      +EL+  R ++LE + R   F R+AE+L+ W+  +
Sbjct: 4    SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63

Query: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774
             Q A   +   +DP +      K   F+ +V+  S  +         ++  GH A   +R
Sbjct: 64   LQIA--SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121

Query: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833
             R  +L   W  L E  + +G  L   +  ++  R+  +V+  + +K A      + +DL
Sbjct: 122  TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181

Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGR-VQKLCPGPQAHAVQQRQQAVTQAWAV 1892
              +E   +  +  + ++   E ++ E+ + A + +Q+    P+   ++ +Q  V  AW  
Sbjct: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE--QHPEEELIKTKQDEVNAAWQR 239

Query: 1893 LQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
            L+    QR+ +L  A  + RF   V +  SW     Q +  ++  ++ +S    L  H+ 
Sbjct: 240  LKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEG 299

Query: 1953 LRAELEARE----KLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQE 2008
            L  +L A E     L  +A +L Q   L+A     ++Q +   L    +Q+    A +  
Sbjct: 300  LERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHA 355

Query: 2009 RLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK 2068
            RL    + Q FL +   L   +   +  +    L S V   E L+ +H+     + A + 
Sbjct: 356  RLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED 415

Query: 2069 KEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQA 2122
               +  E  + L          VR++L +L + R  + EL E R       + +  F + 
Sbjct: 416  SFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475

Query: 2123 ATQAEDWI-QAWAQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEAL 2180
              Q ++W+ +  A  L E +  GD  D ++ LL KH+ FE  + A EE +T++ +    L
Sbjct: 476  TEQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533

Query: 2181 LAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKE 2240
            +  +H    +V+ R   L      L +    R  +L D  +  +F +  D  ++W+ EK 
Sbjct: 534  IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK- 592

Query: 2241 VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKII 2300
            +K    +  +D  +   L+ ++++ +   A  +   + I ++     +L + +      +
Sbjct: 593  MKTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649

Query: 2301 CQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKD 2360
              R +++ + W            +L  A +    +R ++++   + E E  + + D GKD
Sbjct: 650  AARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD 709

Query: 2361 LESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQL 2420
            L +VQ L +KH  LE +V   Q +++ +  +  +        A  ++ +Q+ +   +  L
Sbjct: 710  LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769

Query: 2421 RSRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQE 2479
            +     R++ L D+L   Q  + +  E     ++      T+   +  +  + +L++HQ 
Sbjct: 770  KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQA 828

Query: 2480 CKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
             +AE+      I      G  ++  GH  + D++  L  L Q+  +L+    + +  L+ 
Sbjct: 829  LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED 888

Query: 2540 ALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISA 2599
            +L+ Q + +   + E W+  KE  + S          E LL KH+ L  DL      I A
Sbjct: 889  SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948

Query: 2600 LEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658
            L   A+   Q   P + ++      A+   +E   R+   ++  +  L  L +  +D  +
Sbjct: 949  LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWK 1006

Query: 2659 VAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHP 2718
            V    R+  + A     LD    PAQ   ++N   E  +   +Q+++  + +   + G  
Sbjct: 1007 VEVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG-- 1060

Query: 2719 ASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAP 2778
               ++  R++++  L+  L +  +K+   L+K+C+   L R   EL+ W+   E  L + 
Sbjct: 1061 ---SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE 1117

Query: 2779 TVGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLA 2826
             VG  L  V  L       Q++L+A       ++K A   ++E L+ +    V++     
Sbjct: 1118 EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYG 1177

Query: 2827 QDVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLK 2862
                ++                         + L +R++SL++  +ER   L +   + +
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237

Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
            F RDADE   W++EK       +YG  L++V+ LQ +H+  E ++++       +  T  
Sbjct: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
            +L+Q+   +A ++  +  +L +A + L   A +R+  L  + + Q+FL++  +  SW+  
Sbjct: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357

Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
               ++ S+++       +ALL R +  + +++A +   +  +Q    L +  +  SP++ 
Sbjct: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417

Query: 3043 AQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDL 3102
             +L  + +  A+L +    R   L + L+L    R+    + W+  + A   ++D G  L
Sbjct: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477

Query: 3103 EGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERL 3162
            + V+ L +K + F K + ++ + K+ AL+  A  L          I ++R+ +   W RL
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536

Query: 3163 DQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRL 3222
               +  +   L  +  +  F +   E++  + EK      ++     +++++  Q+H+  
Sbjct: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQSKHQKHQAF 1595

Query: 3223 ERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQW 3274
            E EL A    +        + ++  AC   +   A    LA + + W  L  K+ E+ Q 
Sbjct: 1596 EAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEKSQK 1653

Query: 3275 LAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQ 3334
            L +A +   F    ++   W  E + L +SE+  +D+A    LL +H+ L  +I     +
Sbjct: 1654 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1713

Query: 3335 AQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRL 3394
             +DL  +   L+ +S F +++V +    + GR Q+++   A R  +  ES  L +  + +
Sbjct: 1714 LKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDM 1773

Query: 3395 EQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
            +  E+W+   + L+   DYG  ++ V+ L  +H+ LE  LAA E
Sbjct: 1774 DDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1817



 Score =  312 bits (800), Expect = 3e-84
 Identities = 457/2326 (19%), Positives = 896/2326 (38%), Gaps = 218/2326 (9%)

Query: 263  LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320
            LLQ Q+      QY +   D++ WI +K+  + + +    L  +  L   F  F+T    
Sbjct: 145  LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200

Query: 321  KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380
               R+ +     A L + Q             H    L +  Q      W +  +  ALQ
Sbjct: 201  HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246

Query: 381  QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437
            ++       E   +RF        S++K+ EQ++   D  R     LA+V+A +++   L
Sbjct: 247  RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300

Query: 438  EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
            E  +   E + +AL   AD L+Q    S   +  ++EE+   W+++      +  ++ D 
Sbjct: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360

Query: 498  QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
              +   L +    +  + E++    +      +A    LL RH   + ++ AH       
Sbjct: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420

Query: 558  AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617
             +    L ++   + + ++ K   L++ + +L+ L   RR   EQ +    F R+ E+ +
Sbjct: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480

Query: 618  AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677
             W+ +    + N  LG  L  +   L+KH+  E  +   +     L      L       
Sbjct: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 678  QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736
              D   R +A+      L  R + R A+L  +  + Q+F D+ E  SW+ E+ +++ + A
Sbjct: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600

Query: 737  SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796
               +D +  +  +++H   E  L A  + +  LE+ G+       L  VN          
Sbjct: 601  Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642

Query: 797  RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856
                                          +  + +    + +   ++ L    +L+  +
Sbjct: 643  -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673

Query: 857  LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914
            L EA     F  +  +++LWL +    L       D   V  L+ ++ L    +A  +  
Sbjct: 674  LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733

Query: 915  WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974
               ++  A Q +     ++  I+++QE L  R+  L+     +  +LA S+ +    ++ 
Sbjct: 734  IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793

Query: 975  GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
               +  +R+      +   G      ++     Q  Q +    E R+  +      + E 
Sbjct: 794  EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
            G+  ++ ++ ++  L    + ++ + +QR +   ++   Q +  ++ +   W    +  +
Sbjct: 854  GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913

Query: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
             S +   D  SA+ LL++H+ L+ ++  +   +Q L  Q+Q       P   E       
Sbjct: 914  GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967

Query: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207
                G+EL +     Q+     + ++K     D  T   + ++ W  +   D  G     
Sbjct: 968  ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019

Query: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265
             +  L   +   R  LL   G  + ALR             A +V  +++ ++  +  L 
Sbjct: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077

Query: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320
               E+R+  L  S +     ++  EL QW+ EK      E  GA    ++ L++      
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137

Query: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357
               +A ES L    +  E L+  G           +E+    P  + D +T         
Sbjct: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197

Query: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408
                      ++ L  +W +L +   ER   L  A + ++  R   + KE +E+   AL 
Sbjct: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257

Query: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467
            +   G DL S Q LQ++H+  E +   L  K+ +L   A  +  S P   E+ Q+    L
Sbjct: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317

Query: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
                  L  R  Q +A    S +L +F       +SW+       S     + + GA++L
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377

Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
              +H+E + E+ A  G  Q     G+ L A GH  +  I ++   L+   A+LE+A   R
Sbjct: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437

Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
               L Q +  Q +  D  + E W+  +   +++ D G    +   LI KH+   + + + 
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497

Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701
               +  L   A  L       +  +   R  + ++ R L+     +  +L  +  L +F 
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557

Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAES 1761
            R+ ++++ W++ + Q A   +   +DP +      K   F+ ++   + R+     +  S
Sbjct: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNS 1615

Query: 1762 LLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ 1819
            L+ERG  AG    V+ R   L   W  L + +  +   L++       +  + +    + 
Sbjct: 1616 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1675

Query: 1820 E-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA 1878
            E +A     +  +DL  +   L+ HQ LE ++   E +L++L   A  +           
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSAFDTSQ 1734

Query: 1879 VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQ 1938
            V+ ++  +   +  ++     RRA+L  +  L +F   + D  SW    +  +  E+  +
Sbjct: 1735 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGR 1794

Query: 1939 EPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQ 1998
            + +        H+ L AEL A E   Q     G++         +E+Q+ L    +   +
Sbjct: 1795 DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKE 1854

Query: 1999 VYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEV 2058
            + Q  A + +RL+   + Q F+      E  +  +   + +   G ++  ++ L++KHE 
Sbjct: 1855 LKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1914

Query: 2059 FLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRGHALHA 2112
            F    T  +D+           +++       +  ++  L  +   +++ A  R   L  
Sbjct: 1915 FETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1974

Query: 2113 SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-HEEVMT 2171
            +     F   A   E WI      LK      DL      L K + F+A +QA  +E + 
Sbjct: 1975 NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIA 2034

Query: 2172 SVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN--------FL 2223
            ++    + LLA  H ++  +  R   L K W  L    A R ++L + ++        FL
Sbjct: 2035 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2094

Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
             F ++     +W +  E  +        LE    LR     FR + +      A    ++
Sbjct: 2095 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQADFNQLA 2151

Query: 2284 DLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLRYQQQL 2325
            +L  Q+K+     +P         EE      KII +R  +L         N    Q+  
Sbjct: 2152 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2211

Query: 2326 EGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPI 2381
            + A   H   +E    L + +  ++E   L   L+  K         RKH+    E+  +
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ----EIRAM 2258

Query: 2382 QAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALHQAQKL 2440
            ++Q++ +E ++G   + +    +    H    +A+ W QL     + +  L+   QA+  
Sbjct: 2259 RSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2317

Query: 2441 QAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486
              + +E L     +    D   + R           HQE K+ L S
Sbjct: 2318 TGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2354



 Score =  289 bits (740), Expect = 3e-77
 Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)

Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
            +ELS+L       + +L+ +   Q F    E++E+W+  K    + E   DP   ++  L
Sbjct: 30   KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82

Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
             KH+  E +++  +G I  L+ T   +   GH  +++   R   +  + E L  +   + 
Sbjct: 83   QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142

Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699
             +L + ++L  +L++ ++V  W+ +K  +   E L         LQK+ + FQ ++ A  
Sbjct: 143  IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202

Query: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759
             +  E+ +   +L+Q  HP  E I+ + +E+ A W  L+  + ++  KL  A E  R  R
Sbjct: 203  ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262

Query: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815
             ++E  +W++  E  + +   G+ L  V  LL    G +R+L A  DK     +AL  +A
Sbjct: 263  DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318

Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875
                +     A  ++ +   L+  ++ +R    ER   L     L +F  D  +  +WV 
Sbjct: 319  DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378

Query: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
            E   L  A +    ++    L ++HQ  + E+ +HE   +    +G  L+ AGH+A+ EV
Sbjct: 379  EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438

Query: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995
              ++  L +  A L      RR   +Q  + Q F  +  +  +W++++   L +ED+G S
Sbjct: 439  REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498

Query: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055
             ++ +ALL++ E  ++ L A   +I  L + A  L    +     V  +  A+      L
Sbjct: 499  LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558

Query: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115
              RA  R   L +   L Q  R++  L +W+  K  TA  + Y +D   ++   +K  AF
Sbjct: 559  HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617

Query: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175
              E+ S  Q+++ AL K    L          + A+ + + + W++L +A + +   L  
Sbjct: 618  EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676

Query: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235
            A++   F +   +++  + E    +  +D G  L++V+ LQ++H  LE ++ A +  +  
Sbjct: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736

Query: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
            +  +A +           + K QEA    +  L+     R Q LA + +        ++ 
Sbjct: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796

Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
              W +E++ +A+S    +D+ G + LL +H+ L  EI     + + + Q+G  +V+  HF
Sbjct: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856

Query: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
             + +V   L EL  + + L+   + R Q   +S   Q+      +AE+W+   E ++   
Sbjct: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916

Query: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464
            DYG      E LL +H+ L   L+A       +++        + P + + G+
Sbjct: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969



 Score =  268 bits (684), Expect = 1e-70
 Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)

Query: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674
            A+    R Q +L R       +  RR +LE+  + Q F +D++E+  W++EK  +A +E 
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
              D   L  +LQK Q F+AE+ A+     +L   G  ++  GH ASE I+ RL EL   W
Sbjct: 72   YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
              L +  ++K  KL +A + ++  R  E++ +W+   E  + +  +GQ L  V  L    
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851
             E +  +     +   +   A   ++E H    L +  +++     QR K L     +R+
Sbjct: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248

Query: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
              L   + + +F RD DE ++W++EK  L A+ D+G+ L++V+ L  +H+ LE ++++ E
Sbjct: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
               + +     +L Q+   +A ++  + ++L      +R  AA R   L  +   Q+FL 
Sbjct: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031
            +  +  SW+ E   +++++++       +ALL R +  K +++A     +   ++   L 
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091
            +  +  S +V  +L  + E  A LL   E R    ++ + L    R+T  +D W++ + A
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151
               ++D G  L+ V+ L +K + F K + S  + K+ AL + A  L +        +  +
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547

Query: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
            R  + +    L +    R   LA +  +  F + + EL+  + EK      ++     S+
Sbjct: 548  RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606

Query: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267
            ++   Q+H+  E EL A +  +  L+    +L  ++  A   +A    +V   W  L   
Sbjct: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327
             + +G  L +A Q   F    +++  W  E +   +S++  +D+   + L  +H  L  +
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726

Query: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387
            +   + +   +  + +Q  D  HF +  + +  + L  R + L+E    R Q+ A+S  L
Sbjct: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786

Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
            Q+L + +E  E W+   E +    + G  +  V+ LL +HQ L+  +A  E +
Sbjct: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839



 Score =  223 bits (569), Expect = 2e-57
 Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
            A ++  R QQ+       +  +  RR  L+ +   Q F  +  E   W+ E+  +   E+
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
                    Q  L++ +A + +++A S  I +L +T  L+ S  +  S  +  +L  +   
Sbjct: 72   YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130

Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
               LL +   +G  L +  +L Q  RE   +  W+  K A   S++ GQDLE V+VL++K
Sbjct: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190

Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
            F+ F+ ++ +  + +V  + + A  L +        I+ ++  + AAW+RL      R  
Sbjct: 191  FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249

Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
             L  A EV  F +   E    ++EK  LM  +D G  L+SV+ L ++H  LER+L A+E 
Sbjct: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309

Query: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287
            +V  L  EA RL Q HP +   +   +E     W  ++  A ER   L  + +   FL  
Sbjct: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369

Query: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
             ++L +W  E + L +++ELA DVAGAE LL +H+E   EI       +   + GQ L+ 
Sbjct: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429

Query: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407
              H+ S EV E L  L      L E W LR Q+  +   LQ   +  EQ + W++  E  
Sbjct: 430  AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489

Query: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
            LL  D G S+  VE LL +H+D EK L+AQEEK   + +
Sbjct: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528



 Score =  125 bits (314), Expect = 8e-28
 Identities = 211/1116 (18%), Positives = 440/1116 (39%), Gaps = 122/1116 (10%)

Query: 376  SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426
            ++ LQ++  +L Q   +L +R  Q KA L +S     FL D   ++         +++  
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366

Query: 427  -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479
                    EA ++R       I  + G FQA  +    L    +++  ++ +++ ++  +
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425

Query: 480  WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
             +  L+    QR+ + D    L L  ++ E A + +   +    +   G  L  V  L++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485

Query: 539  RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
            +H+  +  ++     ++ L     +L ++   +   + ++   +    + L A +  +R+
Sbjct: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545

Query: 599  LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
             L ++    +F R+ +E EAW+ E  Q   + +  +D + I    QKH+A EAE+H +  
Sbjct: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHANAD 1604

Query: 659  VCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLVLQYF 716
                ++  G  L  R      +   +A   A+   WQ L  +   +  +L+ A     + 
Sbjct: 1605 RIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFN 1664

Query: 717  ADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAA 776
                +   WL E  + L     G+D A+   LL++H  LE  + A    L+ L  Q    
Sbjct: 1665 TGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD-- 1722

Query: 777  SARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQ 836
                SL T ++                                       FD + +   +
Sbjct: 1723 ----SLMTSSA---------------------------------------FDTSQVKDKR 1739

Query: 837  DHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEV 896
            D ++  ++ ++++A  RRA+L E+  L  F     + + W++++ +L+       D   V
Sbjct: 1740 DTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGV 1799

Query: 897  MQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALK 954
              L  K++     LA  +     V  + ++L         +IQ++  +  + W +L+ L 
Sbjct: 1800 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLA 1859

Query: 955  REKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE 1014
              +  +L  S+E   F+      +  + + +  + +   G   DT  A+Q   KK    E
Sbjct: 1860 AARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKHEAFE 1916

Query: 1015 R-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
                    RV+ + +    + +      + +  +++ L G +  +++  AQR  +  E  
Sbjct: 1917 TDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENS 1976

Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QERLQQL 1126
            A   F  ++  +  W    +  L++ +   D++S Q LL + +     +  + QE +  +
Sbjct: 1977 AFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2036

Query: 1127 DAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFT 1186
             A    + A     S+ +      L ++  +L      R++ L   LE Q   R+V+   
Sbjct: 2037 TALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVEDLF 2093

Query: 1187 ATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEALRAH 1235
             T A   +  +   +N  ED         + E  +L + H  F   LS+       L A 
Sbjct: 2094 LTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQL-AE 2152

Query: 1236 GEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQLQEWK 1285
             ++ ++S   A++      +++++  W  LQ          + EQRR++    L+ QE+ 
Sbjct: 2153 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFA 2211

Query: 1286 QDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
            Q      QW++E            E SG   + L+  KR      E+ A R  ++ ++ +
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKKIEDL 2268

Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
            G  +        +  +    GL  +W+ L++        L+Q  Q        ++A ++ 
Sbjct: 2269 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEF 2328

Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436
              +       ++G         +  HQ+ +S  R+L
Sbjct: 2329 SMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2355


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score =  637 bits (1644), Expect = 0.0
 Identities = 544/2269 (23%), Positives = 999/2269 (44%), Gaps = 109/2269 (4%)

Query: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218
            K L   R+Q L++    Q F R+ +         +  +  D   +D       LQ+H+ F
Sbjct: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88

Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
               +         L   G  ++   H A+ T+R +L  +  QW  L  +  ++  +LL +
Sbjct: 89   EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148

Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337
             +L ++ ++  ++M W+ +K  +   E  G     ++ L K+ E  ++++ A    V  +
Sbjct: 149  QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208

Query: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397
             Q   +L+  +   +E I+T+   + + W+ L     +R  +L  A + ++  R + +  
Sbjct: 209  NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268

Query: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457
              +++ E  + S + G+DL S Q L ++H+ LE +   L  K+ AL + A  +  S   L
Sbjct: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327

Query: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
              TQ  ++R EL+     IR L      +L  S  L +F        SWV E     +  
Sbjct: 328  SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387

Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
                 + GA++L  +H+E + E+ AH+   +    SG++L A+GH  +  + E+   L  
Sbjct: 388  ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447

Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
              A L    E R Q  +Q +  Q ++ D  +++ W+ ++   + + D G    +   L+ 
Sbjct: 448  ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507

Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689
            KH+  ++ L+     +  LD+ A  L        + V   R  L  +  AL E A  R  
Sbjct: 508  KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567

Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
            +L  +  L +F R++++L+ W+  + + A   +   +DP +      K   F+ ++    
Sbjct: 568  QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625

Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
             R+ A     + L++  H A   V  R  ++ + W +L E T+ +G  LR+     + +R
Sbjct: 626  SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685

Query: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868
            ++ ++   + E    L ++   +DL  ++   + H  LE ++   + ++  +   A + Q
Sbjct: 686  NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745

Query: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928
                   A  ++++Q+A+   +  L+  M  R+ +L  +  L +    V D  +W  R +
Sbjct: 746  D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803

Query: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
            + +    +  +   G   L   HQ L+AE+   E   +  TQ G   +       ++V+ 
Sbjct: 804  EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863

Query: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047
            +L  L  + + +    +++++ L+   Q Q +  +    E  +  +E  + ++  G   +
Sbjct: 864  KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923

Query: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099
              E L++KHE  +  L+A      ALRE+ ++ R+            L + L   +    
Sbjct: 924  SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983

Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159
            +E+   +G  L         T   +  +DW +      +  VP   ++ KL P     A 
Sbjct: 984  REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028

Query: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
             A  +   E   S+A + E +  Q+     AG VS R++ + + +  L +    R   LE
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088

Query: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276
               + F+ F +  +L + WI EKE  +   ++G DLE    L+++  +F+ +   +    
Sbjct: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147

Query: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304
              I  +++  L+ +    EEV+ + Q+                                 
Sbjct: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206

Query: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
               +LN RW S         Q L  A E+    R+ D   + I+EK   +   + G DL 
Sbjct: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266

Query: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422
            SVQ L RKHE  ER++  +  +V SL     RL Q  PE+A  L+ +  E+ ++W  L  
Sbjct: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326

Query: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482
            RA +R+  L   H  Q+  +  ++L+     +R  + +    +    A  +LE HQE + 
Sbjct: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386

Query: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542
            E+D+   +       GQQLL  GH  S +I+Q L  L+QE + LE AW + ++ L Q LE
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446

Query: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602
            LQLF    E+ E W+ ++E  L +E   D L  +E L+ KH+  +  + VQ  KI+AL+A
Sbjct: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506

Query: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
             A  L   GH        R   +L R   L  Q   +R +L E + LQ F +D  E+ AW
Sbjct: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566

Query: 2663 LREKNLVALEEGLLD-----TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
            + EK   A +E   D      + L ++ QK Q F+AEL A+  + + +   G  L++ G 
Sbjct: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626

Query: 2718 PA--SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVEL 2775
             A   +A++ RL  L   W  L   S +K  KL++A +       +++ + WL  +E  L
Sbjct: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686

Query: 2776 RAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARR 2835
             +   G+ L  V  LL   + LEA +     + + L  QA + +         V+++   
Sbjct: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT 1746

Query: 2836 LLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRH 2895
            +  RF+ ++     RR  L     L +FFRD D+E +W++EK  L  ++DYG+ L+ V++
Sbjct: 1747 INGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQN 1806

Query: 2896 LQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
            L+++H+ LE+E+++HE   + VL TG KL         E+  R+ Q  +    L+  AA 
Sbjct: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAA 1866

Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
            R   L+++ E QQF+  + E  +W+ E+  ++ SED G +  A Q LL++ EA + D   
Sbjct: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926

Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
               R+  +      L  + N     + ++++ +    ++L + A  R   L E     Q 
Sbjct: 1927 HKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986

Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
              +  ++++W+  K  + ++ DYG+DL  V+ L  K + F   +Q+  Q  +  +  L  
Sbjct: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKD 2046

Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAA 3187
             L      +   I+A+ + +   W +L     AR + L  A            +F + A+
Sbjct: 2047 QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKAS 2106

Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACR 3242
                  +     +      +SL  ++ L++ H      L + + +  +L     Q ++ R
Sbjct: 2107 AFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFR 2166

Query: 3243 LGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAW 3294
            +   +P     +  ++E W  LQ   +ER   L +  +           F         W
Sbjct: 2167 VAS-NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225

Query: 3295 AQE-RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
             QE R  L     + E+    E  L   +   QEIR  R Q + +   G
Sbjct: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274



 Score =  570 bits (1468), Expect = e-161
 Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)

Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142
            +++R   +L R  R KEL+  R   L  S     F + A + E WIQ   Q   +     
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74

Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
            P +L+ KL+   KHQAFEAEVQA+   +  + + G  ++++ H  +  +  RL  L + W
Sbjct: 75   PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
            E L + M  +G +L   +  +++L+  +    WI +KE  +   +LGQDLEH   L+++ 
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
             EF+ + A     +  +  ++  + +L      E ++I  ++ ++N  W    G  L+ Q
Sbjct: 192  EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248

Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
             +L GA E+   +R++D     I+EKE L+ + D G+DL SVQ LLRKHE LER++  ++
Sbjct: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308

Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
             +V++L  E  RL Q  P +A  ++ +++E+  +W Q+R+ A +R   L+  ++ Q+  A
Sbjct: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
              ++L      ++A ++          A  +L+ HQE K E+D+  DS   A  +GQ LL
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
             AGH  S ++R+ L  L +E ++L   W+  + Q +Q ++LQLF    E+++ W+  +E 
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
             L +E L D L  +E LL KH+  E  L  Q  KI+AL+  A  L Q  H   +    R 
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548

Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
             A+L R+ AL  +A  RR +L +   LQ F +DS E+ +W+ EK   A +E   D + L 
Sbjct: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608

Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
             ++QK Q F+AEL A+  +   L++ GQ+L+   H A + +  R+ E+ +LW +L + ++
Sbjct: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668

Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
             K  KL++A +  +  R++E++E WL  +E  L +   G+ L  V  L      LEA V 
Sbjct: 669  LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728

Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
                + + +  QA+ F   GH  A++++++   L+ R+++L+EP+  R+  L     L +
Sbjct: 729  AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788

Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
             FRD ++E  W++EK P+AA+ + G+ L  V++L ++HQ L++E++ HE   + V   G 
Sbjct: 789  LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
             +V+ GHFAA +V A++ +L +    L+A+A++RR  L+ + +AQQ+  +  EA SW+ E
Sbjct: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908

Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
            +  ++ S D G   ++ +ALL++ EA   DL A+   I+ L++ A     +  P   +  
Sbjct: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968

Query: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100
             +L      + E   R     +G  L      ++   +  + D      AA  +  D  Q
Sbjct: 969  KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028

Query: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
                  +LEE+     ++ Q   Q ++        T E G+      +  +  ++E  + 
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074

Query: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220
             L +  + R   L  + +     + A ELQ  + EK A +  E+ G  L  V  LQ++  
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134

Query: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240
              +++L+A                    M +EV  +Q +                    +
Sbjct: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194

Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
             RL     A    + ++ E W +LQ  A+ER Q L  A +   F     E   W +E+ +
Sbjct: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254

Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
              +++    D+A  + L  +HE   +++     +   L +  ++L+  SH  SAE     
Sbjct: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308

Query: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413
             +L+ +  EL +AW+        R  +  +S  LQ+         +W+    GL+   + 
Sbjct: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367

Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462
               V+  E LL RHQ+    + A+   F   +  +  Q+LL       P
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414



 Score =  548 bits (1413), Expect = e-155
 Identities = 463/1937 (23%), Positives = 876/1937 (45%), Gaps = 91/1937 (4%)

Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
            A+ I E+ Q++   +   +     R Q L+ +  FQ +  D  ELE W++EK  + S  +
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676
            Y +D       + KHQA + E+     ++ +LD+T   +   G    E  R     L  Q
Sbjct: 72   Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130

Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
               L E    +  +L    +L ++LRE ED+  W+ + K+A    E LG+D EH   L  
Sbjct: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            KF +FQ  +    +RV      A  L++  H    +++ +Q ++  AW  L  L   R  
Sbjct: 190  KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855
             L       R +RD+ E ++ ++EK   + ++   RDL  ++A LR H+GLER+L   E 
Sbjct: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309

Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
            +++ L   A R+Q+  P        +R++ +T  W  ++    +R A+L  +  L RF  
Sbjct: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
              RD  SW   ++  +  +E + + +     L  HQ  + E++A E  ++ A + GQ  L
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
             A    + EV+E+L  L ++R  + + W  ++++ +     QLF R+  +++  ++ QE 
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089
             L    LG S++ VE L++KHE F K L+AQ++K  AL E    L +        V  R 
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548

Query: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147
              LL RR  + E A  R   L  S  +  F + + + + W+    +   +     P +L+
Sbjct: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608

Query: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207
             K++   KHQAFEAE+ A++  + ++ K G+ L+  +H    EV+ R+  +   W+ L +
Sbjct: 609  GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665

Query: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267
            A  L+G +L +     +F + V+  E W+ E E  +   D G+DL +   L+++      
Sbjct: 666  ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725

Query: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
            + A        I  I+  + Q ++    + + I +++  L  R+ +    ++  +Q+L  
Sbjct: 726  DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782

Query: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387
            +L +  L R++++    I+EKE +  + + GKDL  VQ LL+KH+ L+ E+   + ++++
Sbjct: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842

Query: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
            + ++   + +    AA  ++ +  E+ + W  L+++A +RR+ L+   QAQ+  A   E 
Sbjct: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902

Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
                +     + ++   +    A  +L++H+   ++L ++  SI   R   Q       P
Sbjct: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962

Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
               +      G E  L+  +   +  +    +  ++   L+S  K + W     D     
Sbjct: 963  TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014

Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627
              + P A ++ L         +L  + G I AL             EA S   R + +  
Sbjct: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071

Query: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686
               +L      R+  LE+  +     +++ E+  W+ EK   +  EE   D   +    +
Sbjct: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131

Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726
            K  +FQ +L A+  + +++ +  + L   G  A E  A+Q++                  
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191

Query: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
                            ++EL   W  LQ  ++++   L  A E  R  R  +E + W+E 
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251

Query: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
                L     G  L  V  L     G +R+L A  DK      +L   A+  ++     A
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307

Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886
            +D++E+   L Q + SL +   +R+  L     L +F  D  + M+W+     L ++ + 
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367

Query: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946
             + ++    L E+HQ   +E+ +     +     G +L+  GH+A+ E+  ++  L++  
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427

Query: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006
            A L     +RR++L Q  E Q F  +  +A +W+A R   L++ED G S ++ +AL+++ 
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487

Query: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066
            E   + +     +I  LQ  A  L +  +     + ++   V +    L  +   +   L
Sbjct: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547

Query: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ--DLEGVKVL--EEKFDAFRKEVQSL 3122
             E   L Q  R+   ++AW++ K  TA  + Y    +++  K+L   +K  AF  E+ + 
Sbjct: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHAN 1607

Query: 3123 GQAKVYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHS 3181
                   +      +ERGA       ++A+ + +   W+ L Q    +++ L  A++  +
Sbjct: 1608 ADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQN 1667

Query: 3182 FQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEAC 3241
            F     +    + E  AL+  ED G  L+SV  L ++H+ LE ++ A E  +  L ++A 
Sbjct: 1668 FNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA- 1726

Query: 3242 RLGQLHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAW 3294
                L  ++    ++V++   T+  + Q+       R   L ++ + H F     +  +W
Sbjct: 1727 --DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1784

Query: 3295 AQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSA 3354
             +E++ L  SE+   D+ G + L  +H+ L  E+       Q +   G++L D++     
Sbjct: 1785 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1844

Query: 3355 EVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYG 3414
            E+ + L +     +EL++  A R QR  ES   Q+    +E+ EAW+     L+   DYG
Sbjct: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1904

Query: 3415 HSVSDVELLLHRHQDLE 3431
             +++ ++ LL +H+  E
Sbjct: 1905 DTLAAIQGLLKKHEAFE 1921



 Score =  534 bits (1375), Expect = e-151
 Identities = 509/2224 (22%), Positives = 951/2224 (42%), Gaps = 143/2224 (6%)

Query: 827  FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884
            F   TI      L + +E L    + +  +L +A  L  +   C ++  W+  +  ++  
Sbjct: 115  FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174

Query: 885  QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944
            + +    + +EV+Q K+E F T +A  +    EV+  A +L Q        I+ +Q+E++
Sbjct: 175  EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234

Query: 945  QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003
              W +L+ L  ++  +L  + EV  F ++   T   +++    + +   G    +  AL 
Sbjct: 235  AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294

Query: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060
               +  ++    LE +V  L +   ++++     +  +Q + E L    +Q++   A+R 
Sbjct: 295  RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354

Query: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120
             R  ++   Q FL + + L  W   ++A + + E++ DVA A+ LL  HQ+   EI   +
Sbjct: 355  ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414

Query: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180
            +  +  D   Q + A     S EV   L VL ++   L  LWE R+Q  ++ ++LQ F R
Sbjct: 415  DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474

Query: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
            + +      +  +A+L  ++LG+ +    +LL++H +F + LS    +  AL     KL+
Sbjct: 475  DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534

Query: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300
            Q+ H A   V  +  ++ ++   L  R+ +RR QL  S  LQ++ +D  EL  W+ EK  
Sbjct: 535  QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594

Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360
             A  E      N+   +++H+A E+EL A +  ++AL++ G++L+      ++++  R+ 
Sbjct: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654

Query: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
             + S W+ L      +G +L++A QQ+Q  R ++D +  L ++EG L S + G+DL + Q
Sbjct: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714

Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475
             LQK+H  LE++      ++  +   A      G   +  I ++ +  + R E L+  + 
Sbjct: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774

Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
             R  +L  S+ L Q       E +W+ E  P  + T+  + L G Q+L +KH+ LQ E+ 
Sbjct: 775  ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834

Query: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595
             H+ +++ V   G ++   GH  A+ +  +  EL   W  L+     R Q L+ ++  QQ
Sbjct: 835  GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894

Query: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655
            YF D +E E W+ EK P+V S DYG+DE +   L+ KH+AL  +L+ Y SS++ L + AQ
Sbjct: 895  YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954

Query: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703
            +      P       E  +E + AL +      RE+  T++  + L             E
Sbjct: 955  SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008

Query: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763
              D QG++ +     K   +     E+ L      A  Q Q++  +      R+  E+  
Sbjct: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059

Query: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823
                     V  R + ++  +  L EL + R   L  +     + R+  E+   + EK  
Sbjct: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112

Query: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881
            +L +  V  DL  +E   +     +++L   E +L+++ + A  ++ +     +  AVQQ
Sbjct: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172

Query: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907
            ++                                  + + + W  LQ+  E+R   L  A
Sbjct: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232

Query: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967
              + RF     +   W     Q L  +    + +S       H+    +L A   L  + 
Sbjct: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289

Query: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019
              LG+ A  L    P     E    LQ++  ++ Q W+       +++ +L      Q F
Sbjct: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344

Query: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079
            L +   L   +      + +  L   V   E L+ +H+     + A+     A  +  + 
Sbjct: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404

Query: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
            L        P ++ +L IL Q R  +++    R   L   L +  F +   QAE+W+ A 
Sbjct: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463

Query: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192
             +        GD  D ++ L+ KH+ F+  +   EE + ++    + L+A  H   G++S
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523

Query: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252
             R   +   W  L+  M  +  +L + +   +F + VD  EAWI EK       D     
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK--LQTASDESYKD 1581

Query: 2253 EHCLQLRRRLREFRGNSAGDTVGDA---CIRSISDLSLQLKNRD--PEEVKIICQRRSQL 2307
               +QL + L + + + A +    A    IR + D+   L  R         +  R + L
Sbjct: 1582 PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAAL 1641

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
             ++W           Q+L+ A +    +  + +    + E EAL+ + D GKDL SV  L
Sbjct: 1642 ADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701

Query: 2368 LRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR 2427
            L+KH+ LE ++   + +++ L  +   L   S      ++ ++  +   + +++S A  R
Sbjct: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761

Query: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487
            R  L+  H+  +    + +     +  +  + +    R     + + ++H+  +AEL + 
Sbjct: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821

Query: 2488 TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
              +I     TG++L         +I+Q LA   +    L+        +L+++LE Q F+
Sbjct: 1822 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1881

Query: 2548 SSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGL 2607
            ++VE+ E W+  K   +ASE   D LA ++ LL KH+  E D  V   +++ +    + L
Sbjct: 1882 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941

Query: 2608 HQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
             +  +   ++   + + +  +   L + A  R+ +L+E      F   +  V +W+ EK 
Sbjct: 1942 IKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKE 2001

Query: 2667 NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQE 2725
            N +  ++   D + +   L KQ+ F A L A   +    +     +LL   H  S+AI+ 
Sbjct: 2002 NSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEA 2061

Query: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRA 2777
            R   L   W +L  NS  +  KL +A    R          +      +W E  E +L  
Sbjct: 2062 RHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTD 2121

Query: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------A 2826
            P    +L  +  L    RE   A       A+A   Q     R+                
Sbjct: 2122 PVRCNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTM 2177

Query: 2827 QDVEEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL----- 2880
            + +EE  R L +  K     LQ E+R   E   L  +F + A+    W+QE         
Sbjct: 2178 EALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGS 2237

Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
               ++ G   S +   + +HQ + +  S  + +  +       L+    +  H      Q
Sbjct: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQ 2297

Query: 2941 QLEK 2944
            Q ++
Sbjct: 2298 QWDQ 2301



 Score =  513 bits (1321), Expect = e-144
 Identities = 548/2418 (22%), Positives = 1012/2418 (41%), Gaps = 212/2418 (8%)

Query: 571  SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630
            + E +Q + + +         L   RR  LE + +   F R+ EE E W++E  Q + + 
Sbjct: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69

Query: 631  ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
               +D + + G LQKH+A EAEV  +    V L   G  + +           R   +  
Sbjct: 70   ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129

Query: 691  GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750
             W+LL  ++  +G +L  A  ++QY  +  +   W+ ++ + +     GQD    E L +
Sbjct: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189

Query: 751  RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810
            +    E      AA   R+ E  + A+                                 
Sbjct: 190  K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213

Query: 811  PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870
                 K+     P+ +     I   QD ++  ++ L+ LA  R+ +L  A  +  F    
Sbjct: 214  -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264

Query: 871  GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928
             E   W++++  L+       D   V  L  K+E     LA  +     + + A++L+Q 
Sbjct: 265  DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324

Query: 929  YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988
            +P ++TQIQ ++EEL   W Q+  L  E+  +L  S  +  FL +       + ++   +
Sbjct: 325  HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384

Query: 989  EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041
             A +  S      AL L + +    E   H  +      +E G A        S  ++ +
Sbjct: 385  NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441

Query: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101
            +  L      + E    R ++  +    Q F ++++Q+  W    +A L ++++   + S
Sbjct: 442  LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501

Query: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161
             + LL++H+D  + +   +E++  LD  +  +   +    ++V      L  +   L   
Sbjct: 502  VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561

Query: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221
              +R+  L +   LQ+F R+ D   +   N +     D   +D       +Q+H+ F   
Sbjct: 562  AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620

Query: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
            LS    R +AL   G+KL+   H A   V  ++  + + W +L   +E +  +L  + Q 
Sbjct: 621  LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680

Query: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
            Q++ ++V ++  W+ E +G +A+ +      N+    K+H   E+++ A +  ++ +   
Sbjct: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740

Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
             R+         E+I+ + + L +++EAL   M  R  +L  + + +QL R ++D +  +
Sbjct: 741  ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800

Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455
             + E    S+  G+DL   Q L K+HQ L++E      R  A      A +  G  A+  
Sbjct: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860

Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
            +  +  +  ++ E L+   + R   L+ S++  Q+   +N   SW+ E  P    T Y +
Sbjct: 861  VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574
              + A++L +KH+ L  ++ A+   +Q +             QAQ   +Q    +     
Sbjct: 921  DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969

Query: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
            EL  A     +   + VT ++      L+ +  + W  E    V+ R  G   AA ++ +
Sbjct: 970  ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681
            +  Q+   E     + +EE  Q +  L   ++  Q R+ +E         ++ E   +L 
Sbjct: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077

Query: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741
            EL   R   LE + +     REA +LQ W+ ++K+AA   E +G D E    L  KF  F
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136

Query: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779
            Q  ++    R+     +AE L   G  A  +   +QQ+                      
Sbjct: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196

Query: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
                          L   W  L +L + R   L       R HRD  E    ++EK  +L
Sbjct: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256

Query: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884
              +N   DL  ++A  R H+G ER+L     ++  L ETA R+ +  P   A  +Q++  
Sbjct: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315

Query: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944
             + QAW+ L +R +QR+A+L  +  L RF +  RD  SW   +R  +  +E +++ +   
Sbjct: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375

Query: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004
              L  HQ  R E++AR   +Q   Q GQQ L      + E++++L  L  +R  + + W 
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435

Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
            +++  L    + QLF R+C + E  +AA+E  L T   G S++ VE LI+KHE F K + 
Sbjct: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495

Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
             Q++K AAL+     L       +  +  R   +L R  R+K     +   L  S  +  
Sbjct: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555

Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL----KHQAFEAEVQAHEEVMTSVA 2174
            F++   + E WI    Q   +         +L  LL    KHQAFEAE+ A+ + +  V 
Sbjct: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615

Query: 2175 KKGEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLA 2232
              G +L+ +      E  V  RL  L   W+ L Q  A + Q+L++      F   +   
Sbjct: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675

Query: 2233 EAWIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLK 2290
            + W+ E E  +   D G+DL     L  + +L E   ++  D + D  + S +D  +   
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSS 1733

Query: 2291 NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEA 2350
              D  +VK    +R  +N R+          + +L  +  +H   R++D+    I+EK+ 
Sbjct: 1734 AFDTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKL 1790

Query: 2351 LIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQ 2410
            L+ + D G+DL  VQ L +KH+ LE E+   +  ++ +     +L   +      ++ R 
Sbjct: 1791 LVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRL 1850

Query: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470
             +  E W +L+  A  R + L+   + Q+  A ++E           + +     +    
Sbjct: 1851 AQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAI 1910

Query: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530
            + +L++H+  + +     D ++   + GQ L+   +    +I   + GL  ++S LE A 
Sbjct: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAA 1970

Query: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590
             + + +L +      F    + +E W+  KE+SL ++     L+ ++ LL K +  +  L
Sbjct: 1971 AQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGL 2030

Query: 2591 EV-QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ- 2648
            +  Q   I+ + A    L    H ++++   R  +++ R   L   +  R+ +L E +  
Sbjct: 2031 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2090

Query: 2649 -------LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL 2695
                      F + +    +W         EE L D         + A  +    F++ L
Sbjct: 2091 FRKVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145

Query: 2696 ---DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
                A  +Q  EL R+ +      +P +    E LEE    W  LQ   +++  +LQK  
Sbjct: 2146 SSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQ 2202

Query: 2753 ----EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLG 2792
                E  +LR+   +  N    W++     L         + T+   L        E+  
Sbjct: 2203 RRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA 2262

Query: 2793 TQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT 2852
             + +L+   D  A   EAL+   +        LAQ  ++  +  ++   +L + +Q R T
Sbjct: 2263 MRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2322

Query: 2853 ------ALEARSLLLKFF 2864
                  AL+  S++ K F
Sbjct: 2323 TGVTEEALKEFSMMFKHF 2340



 Score =  474 bits (1219), Expect = e-133
 Identities = 448/1918 (23%), Positives = 797/1918 (41%), Gaps = 177/1918 (9%)

Query: 244  HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293
            HY S  + +  TV       LL+L E  L + QYEQ +   L          W+++++  
Sbjct: 432  HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489

Query: 294  LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349
            L   D  DSL ++  LL     F      QE+        A + +            RR 
Sbjct: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549

Query: 350  FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409
             L                L    A   +A+++R  QL     L + F+    L+    + 
Sbjct: 550  AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592

Query: 410  AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469
             +   D+A   P++L   +  VQ+    EA +   + R  AL +    L    +++  +V
Sbjct: 593  MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649

Query: 470  ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527
            A R  EV   W++LL+   L+G + + A+ Q   +  + VE     L E++    S   G
Sbjct: 650  AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707

Query: 528  QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587
            + L  V  L ++H LLEA V+AH   +  +  Q  +   +     E ++ K   L    +
Sbjct: 708  KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767

Query: 588  SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647
            +L   + AR+  L  +L+  +  R+ E+EE W++E      +   G+DL  +   L+KH+
Sbjct: 768  ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827

Query: 648  ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707
            AL+AE+  H+     + ++G  +         D   +   +   W+ L+ +   R   L+
Sbjct: 828  ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887

Query: 708  TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767
             +L   QYFADA EA SW+RE+   +     G+D+ +AE LL++H  L   L A+ + ++
Sbjct: 888  DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947

Query: 768  RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816
             L EQ ++   + +           L   +     P E     G       +    D WK
Sbjct: 948  ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006

Query: 817  MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857
            +        +PA      DP        +L+ Q  ++   E +    ++ +       R+
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066

Query: 858  EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894
            ++   L+      GE                     LQ W+ ++   L  + V    + +
Sbjct: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126

Query: 895  EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941
            EV+Q K+++F   L   +    +++  AE L  +       Q  +QQE            
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186

Query: 942  -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
                                   EL++RW  L+ L  E++  L  + EV  F ++   T+
Sbjct: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246

Query: 979  VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034
              + +    L     G    +  ALQ      ++    L  +V+ L     ++ +     
Sbjct: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306

Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094
            ++ LQ +   L      + ++  QR  +  ++   Q FL + + L+ W   ++  + S E
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366

Query: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154
            ++ DV  A+ LL  HQ+   EI       Q  +   Q + A     S E+   L +L Q+
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426

Query: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214
              +L+  W QR+  L + LELQ F R+ +      A  +A+L+ ++ G+ +    +L+++
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486

Query: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274
            H +F + ++    +  AL+A  ++L+ + H A   +  +   +  +W RL+ +  ++R +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546

Query: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNI-----LQTLKRHEAAESELLA 1329
            L  S  LQ++ +DV E+  W+ EK   A+ E      NI     L   ++H+A E+EL A
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606

Query: 1330 TRRHVEALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387
                +  +  +G  L+ R  C G ED ++ RL  L  +W+ L +K  E+  +L++A +Q+
Sbjct: 1607 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1666

Query: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447
                 ++D    L ++E  L S + G+DL S   L K+HQ LE++      ++  L S A
Sbjct: 1667 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1726

Query: 1448 HGMAASPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVA 1502
              +  S A      K  R     R + ++   A R  +L  S  LHQF    + E SW+ 
Sbjct: 1727 DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIK 1786

Query: 1503 EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHI 1562
            E         Y   L G Q+L +KHK L+ E+ AH+  +Q VL +G+ L+       + I
Sbjct: 1787 EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEI 1846

Query: 1563 VEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRD 1622
             ++  +   HW EL++   AR Q L++++ +QQ+  +V E E W+ EK  LV+S DYG  
Sbjct: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDT 1906

Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRAL 1680
             AA   L+ KH+A + +  ++   + ++    Q L       ++ +  +   L  ++  L
Sbjct: 1907 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDL 1966

Query: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
            ++ AA R  +L+      +F  +A+ ++ W+  ++ + K  +  G D      L TK   
Sbjct: 1967 EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQET 2025

Query: 1741 FQHQVEMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799
            F   ++   Q  +A    L + LL   H     +  R   L   WS+L   + AR   L 
Sbjct: 2026 FDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLL 2085

Query: 1800 DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLEREL 1850
            + ++  R   DL     +      S   N   DL           ++A   +H      L
Sbjct: 2086 EAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145

Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RA 1902
               +    +L E   +++        +      +A+ + W  LQ+ +++R        R 
Sbjct: 2146 SSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRR 2204

Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAEL 1957
            Q E  +L   F      +  W    R  L      VEES    S        HQ +RA  
Sbjct: 2205 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2264

Query: 1958 EAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
               +K+      + +  +L      K  +     L  Q DQ+ Q   R Q  L+ + Q
Sbjct: 2265 SQLKKIEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318



 Score =  465 bits (1196), Expect = e-130
 Identities = 440/2064 (21%), Positives = 868/2064 (42%), Gaps = 94/2064 (4%)

Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
            I E  Q+ L R    +    +R  +L+ S     F   +     W+ E +   S  +Y +
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
              N  Q   +KH+  + EV+A+ G + ++  +G  + + GH  ++ I  +  EL   W  
Sbjct: 75   PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133

Query: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
            L      +   L QA    QY  +  ++  W+ +K  +V+S + G+D      L  K + 
Sbjct: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193

Query: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693
             Q ++A +   + E++Q A  L   + PE++  +  Q+ +    + L+ LA  R  +L G
Sbjct: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
               +  F R+ ++   W+  +K+     +  G D      L  K    +  +     +V 
Sbjct: 254  AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312

Query: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
            A    A+ L +    +   ++ ++++L T W ++  L   R   L D+    R   D  +
Sbjct: 313  ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372

Query: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872
            + + V E KA    + +A D+ G EA L  HQ  + E+   E   +   E+   +  L  
Sbjct: 373  LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430

Query: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
            G  A   V+++   +++  A L    E RR Q E+   L  F        +W ++    L
Sbjct: 431  GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490

Query: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
              E+      S    L  H+     L A+E+      +   + +       ++V     A
Sbjct: 491  LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550

Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
            L  +R+ +++   R++ +L      Q F R+   L+  +  +++   T         ++ 
Sbjct: 551  LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609

Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
             ++KH+ F   L+A   +  AL +  + L       +  V  R+  ++    ++ E  E 
Sbjct: 610  KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669

Query: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
            +G  L  +     F +     E W+      L       DL +      KH   EA+V A
Sbjct: 670  KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729

Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
            H++ +  +  +        H  A  + ++ + L   +E L++ M  R Q+L D     + 
Sbjct: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789

Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
             + V+  E WI+EKE      + G+DL     L ++ +  +   AG       +    + 
Sbjct: 790  FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849

Query: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345
             ++  +   E+VK    +  +LN +W +      + +Q LE +L+      + +     +
Sbjct: 850  MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906

Query: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405
            +EKE ++ + D GKD +S + LL+KHE L  ++    + +++L RE  + C++       
Sbjct: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965

Query: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458
               ++  +A   +Q +S  +   K+ + L  L+   K    ++   ++  V A  ++ ++
Sbjct: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024

Query: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518
            D    P        +LEE        +   +   + +  G   L         ++QV   
Sbjct: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069

Query: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
             E+   SL    ++ +  L+++ +  +      ++++W+  KE +L SE +   L  +E 
Sbjct: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128

Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617
            L  K    + DL+    ++  +   A  L   G                       ++++
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188

Query: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
            A     A L+               R  +L + A  R   L    ++Q F +D+ E   W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248

Query: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721
            + EKN     +    D A + A  +K + F+ +L A   +   L    +RL+Q    ++E
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308

Query: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781
             +QE+  EL   W  L   + ++ AKL  + +  R      +L +W+  I   + +  + 
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368

Query: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
            + + G   LL   +E    +D +A   +A     Q  +  GH  + +++++   L Q   
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428

Query: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
             L +   +RR  L+    L  F RD ++   W+  +      +D G SL +V  L ++H+
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488

Query: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
            + +  ++  E     +     +L+ AGH+A  ++++R  ++      L+A+   +R  L 
Sbjct: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548

Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL----RRLEATKRDLEAFS 3017
            ++Q  QQF  ++ E  +W++E+      E          + L    ++ +A + +L A +
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608

Query: 3018 PRIERLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
             RI  +      L  R      +  V A+L A+ +    L++++  +   L+E  +    
Sbjct: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF 1668

Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
                   D WL+   A   S+DYG+DL  V  L +K      ++ S  + ++  L   A 
Sbjct: 1669 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQAD 1727

Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
            +L   +      ++ +R  I   ++++     +R   L  +H +H F +   + +  ++E
Sbjct: 1728 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE 1787

Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG-- 3253
            K  L+  ED G  L+ V+ L+++H+RLE EL A E  +  +     +L   +        
Sbjct: 1788 KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ 1847

Query: 3254 --LAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
              LA+  E W  L+  A  RGQ L ++ +   F+   +E  AW  E+  L +SE+  + +
Sbjct: 1848 QRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTL 1907

Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
            A  + LL +HE    +    + +  D+   GQ L+  ++     ++  ++ L G++ +LE
Sbjct: 1908 AAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLE 1967

Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
            +A A R  +  E+    +   + +  E+W+   E  L   DYG  +S V+ LL + +  +
Sbjct: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027

Query: 3432 K-LLAAQEEKFAQMQKTEMEQELL 3454
              L A Q+E  A +  T ++ +LL
Sbjct: 2028 AGLQAFQQEGIANI--TALKDQLL 2049



 Score =  450 bits (1158), Expect = e-125
 Identities = 488/2272 (21%), Positives = 923/2272 (40%), Gaps = 180/2272 (7%)

Query: 368  LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414
            LE AE    R Q +  R  + + L TL R+          FQ  A   E ++++  Q+  
Sbjct: 9    LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68

Query: 415  DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474
            D+    P +L   +  +Q+    EA +    G    L E  +++  E + +   +  R  
Sbjct: 69   DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125

Query: 475  EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534
            E+  +W+ LL+ ++ +  ++   Q ++  L+E E     + + +    S   GQ L  V 
Sbjct: 126  ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185

Query: 535  ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594
             L ++ +  +  ++AH   V+ + Q  A+L        E+++ K   +    Q L  L  
Sbjct: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245

Query: 595  ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653
             R+  L    +   F R+ +E  +W+KE  Q + +   GRDL+ +   L+KH+ LE ++ 
Sbjct: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305

Query: 654  ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710
                + +A+C +  R    L    P +      + E +   W+ ++T    R ARL  + 
Sbjct: 306  ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361

Query: 711  LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
             + ++ AD  +  SW+ E ++ +       D A AE LL RH   +  + A     +  +
Sbjct: 362  RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421

Query: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
            E G+A  A                                                +  +
Sbjct: 422  ESGQALLAAG---------------------------------------------HYASD 436

Query: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888
             + +    LS++  +L  L +LRR + E+ M L  F     ++  W+ KQ   L  + + 
Sbjct: 437  EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496

Query: 889  PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948
               D++E +  K+E+F  +L+  +     +   A +L Q        +  +++ L  R  
Sbjct: 497  DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556

Query: 949  QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005
             L      +  QLA S  +  F ++    +  + + +     EA + P + +      Q 
Sbjct: 557  ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616

Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065
             + +    + R+  L+    K+ +  +     +  ++  +  L K++ E    +  +  E
Sbjct: 617  FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676

Query: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               +Q F +  + + LW   V+  L S +   D+ + Q L ++H  L  ++   Q+R+  
Sbjct: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
            +  Q++        D++ +      L  + + LK     R+Q L + L LQ+  R+V+  
Sbjct: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796

Query: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245
                   +      N G+D+    +LL++H+     ++   PR +A+   G  +V+  H 
Sbjct: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856

Query: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305
            AA  V+ +L  +  +W  L+ ++ QRR+ L  SLQ Q++  D  E   WM EK  +    
Sbjct: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916

Query: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363
              G   +  +  LK+HEA  S+L A    ++AL++  +    +  P   E  +  +  L 
Sbjct: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976

Query: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415
               E   R++T ++GD L       +   +++    Q       +++L+ A QS+     
Sbjct: 977  DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035

Query: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475
            L     +  R +Q+++++R      +    M        ++LE  +K             
Sbjct: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082

Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
             R   L+ S +       +N    W+ E     +       L   + L +K  + Q ++K
Sbjct: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141

Query: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565
            A++ +++ +      L + G    + Q + +Q                            
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201

Query: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
                   +EL   W  L++  E R+Q L  A   Q++  D  E + W+EEK   +++ +Y
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D A+   L  KH+  + +LA     +  L +TA+ L     PE    +QE+  E  +A
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320

Query: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
               L   A  R  +L  +  L  FL +  DL  W+   +      E L +D   A  L  
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            +  + + +++  +    A     + LL  GH A P ++Q+   L    ++L +    R  
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855
             L         HRD  +    +  +   L      D L  +EA ++ H+  ++ +   E 
Sbjct: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499

Query: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914
            ++  L   A   Q +  G  A   +  R+  V   W  L+ +M ++R++L  ++ L +F 
Sbjct: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557

Query: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPL-----KLSAHQWLRAELEAREKLWQQATQ 1969
              V +  +W +   Q    +ES ++P++  L     K   HQ   AEL A     +    
Sbjct: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616

Query: 1970 LGQQALLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
            +G   +        E  V+  L AL DQ   + Q  A K ++L+   ++Q F       +
Sbjct: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1676

Query: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------ 2081
              L+  E  L +   G  +  V  L++KH++    ++A + +   L  +  +L       
Sbjct: 1677 FWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD 1736

Query: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
              +V+D+   +  R  ++K +A SR   L+ S  +  F +     E WI+     +    
Sbjct: 1737 TSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED 1796

Query: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
               DL        KH+  EAE+ AHE  +  V   G+ L   +     E+ QRL    +H
Sbjct: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEH 1856

Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
            W++L+Q  A RGQ LE+   + +F+  V+  EAWI EK   +   D G  L     L ++
Sbjct: 1857 WKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKK 1916

Query: 2262 LREFRGNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
               F  +     D V D C    +   L  KN   EE   I  +   LN + +       
Sbjct: 1917 HEAFETDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAA 1971

Query: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVH 2379
            + + +L+        + + D V   I EKE  ++  D G+DL SVQ LL K E  +  + 
Sbjct: 1972 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2031

Query: 2380 PIQAQ-VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQA 2437
              Q + + ++     +L       +  +  R   + + W Q L + A ++++ L+A    
Sbjct: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091

Query: 2438 QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARST 2497
            +K++ +       A    +  + +    +       LEE +  +   D++  S+S A++ 
Sbjct: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151

Query: 2498 GQQLL----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
              QL            A +P++      +  LE+   +L+   +E +L+LQ+
Sbjct: 2152 FNQLAELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2200



 Score =  422 bits (1086), Expect = e-117
 Identities = 401/1847 (21%), Positives = 806/1847 (43%), Gaps = 94/1847 (5%)

Query: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714
            +G +V E    +QER ++ L      +EL+  R ++LE + R   F R+AE+L+ W+  +
Sbjct: 4    SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63

Query: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774
             Q A   +   +DP +      K   F+ +V+  S  +         ++  GH A   +R
Sbjct: 64   LQIAS--DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121

Query: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833
             R  +L   W  L E  + +G  L   +  ++  R+  +V+  + +K A      + +DL
Sbjct: 122  TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181

Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
              +E   +  +  + ++   E ++ E+ + A ++ +    P+   ++ +Q  V  AW  L
Sbjct: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-QHPEEELIKTKQDEVNAAWQRL 240

Query: 1894 QRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWL 1953
            +    QR+ +L  A  + RF   V +  SW     Q +  ++  ++ +S    L  H+ L
Sbjct: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300

Query: 1954 RAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
              +L A E     L  +A +L Q   L+A     ++Q +   L    +Q+    A +  R
Sbjct: 301  ERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHAR 356

Query: 2010 LQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK 2069
            L    + Q FL +   L   +   +  +    L S V   E L+ +H+     + A +  
Sbjct: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416

Query: 2070 EAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAA 2123
              +  E  + L          VR++L +L + R  + EL E R       + +  F +  
Sbjct: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476

Query: 2124 TQAEDWIQAW-AQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSVAKKGEALL 2181
             Q ++W+    A  L E +  GD  D ++ LLK H+ FE  + A EE +T++ +    L+
Sbjct: 477  EQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534

Query: 2182 AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV 2241
              +H    +V+ R   L      L +    R  +L D  +  +F +  D  ++W+ EK +
Sbjct: 535  QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK-M 593

Query: 2242 KMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301
            K    +  +D  +   L+ ++++ +   A  +   + I ++     +L + +      + 
Sbjct: 594  KTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVA 650

Query: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361
             R +++ + W            +L  A +    +R ++++   + E E  + + D GKDL
Sbjct: 651  ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710

Query: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421
             +VQ L +KH  LE +V   Q +++ +  +  +        A  ++ +Q+ +   +  L+
Sbjct: 711  TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770

Query: 2422 SRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
                 R++ L D+L   Q  + +  E     ++      T+   +  +  + +L++HQ  
Sbjct: 771  EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQAL 829

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQA 2540
            +AE+      I      G  ++  GH  + D++  L  L Q+  +L+    + +  L+ +
Sbjct: 830  QAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889

Query: 2541 LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISAL 2600
            L+ Q + +   + E W+  KE  + S          E LL KH+ L  DL      I AL
Sbjct: 890  LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL 949

Query: 2601 EATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEV 2659
               A+   Q   P + ++      A+   +E   R+   ++  +  L  L +  +D  +V
Sbjct: 950  REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWKV 1007

Query: 2660 AAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA 2719
                R+  + A     LD    PAQ   ++N   E  +   +Q+++  + +   + G   
Sbjct: 1008 EVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG--- 1060

Query: 2720 SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPT 2779
              ++  R++++  L+  L +  +K+   L+K+C+   L R   EL+ W+   E  L +  
Sbjct: 1061 --SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118

Query: 2780 VGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLAQ 2827
            VG  L  V  L       Q++L+A       ++K A   ++E L+ +    V++      
Sbjct: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178

Query: 2828 DVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLKF 2863
               ++                         + L +R++SL++  +ER   L +   + +F
Sbjct: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRF 1238

Query: 2864 FRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYK 2923
             RDADE   W++EK       +YG  L++V+ LQ +H+  E ++++       +  T  +
Sbjct: 1239 HRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAER 1298

Query: 2924 LVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAER 2983
            L+Q+   +A ++  +  +L +A + L   A +R+  L  + + Q+FL++  +  SW+   
Sbjct: 1299 LIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGI 1358

Query: 2984 GHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLA 3043
              ++ S+++       +ALL R +  + +++A +   +  +Q    L +  +  SP++  
Sbjct: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418

Query: 3044 QLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLE 3103
            +L  + +  A+L +    R   L + L+L    R+    + W+  + A   ++D G  L+
Sbjct: 1419 KLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLD 1478

Query: 3104 GVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD 3163
             V+ L +K + F K + ++ + K+ AL+  A  L          I ++R+ +   W RL 
Sbjct: 1479 SVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537

Query: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED----GGHSLSSVRTLQQQH 3219
              +  +   L  +  +  F +   E++  + EK      E         LS + +  Q+H
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKH 1597

Query: 3220 RRLERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQER 3271
            +  E EL A    +        + ++  AC   +   A    LA + + W  L  K+ E+
Sbjct: 1598 QAFEAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEK 1655

Query: 3272 GQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
             Q L +A +   F    ++   W  E + L +SE+  +D+A    LL +H+ L  +I   
Sbjct: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
              + +DL  +   L+ +S F +++V +    + GR Q+++   A R  +  ES  L +  
Sbjct: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
            + ++  E+W+   + L+   DYG  ++ V+ L  +H+ LE  LAA E
Sbjct: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822



 Score =  308 bits (790), Expect = 5e-83
 Identities = 458/2331 (19%), Positives = 897/2331 (38%), Gaps = 223/2331 (9%)

Query: 263  LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320
            LLQ Q+      QY +   D++ WI +K+  + + +    L  +  L   F  F+T    
Sbjct: 145  LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200

Query: 321  KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380
               R+ +     A L + Q             H    L +  Q      W +  +  ALQ
Sbjct: 201  HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246

Query: 381  QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437
            ++       E   +RF        S++K+ EQ++   D  R     LA+V+A +++   L
Sbjct: 247  RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300

Query: 438  EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
            E  +   E + +AL   AD L+Q    S   +  ++EE+   W+++      +  ++ D 
Sbjct: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360

Query: 498  QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
              +   L +    +  + E++    +      +A    LL RH   + ++ AH       
Sbjct: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420

Query: 558  AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617
             +    L ++   + + ++ K   L++ + +L+ L   RR   EQ +    F R+ E+ +
Sbjct: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480

Query: 618  AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677
             W+ +    + N  LG  L  +   L+KH+  E  +   +     L      L       
Sbjct: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 678  QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736
              D   R +A+      L  R + R A+L  +  + Q+F D+ E  SW+ E+ +++ + A
Sbjct: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600

Query: 737  SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796
               +D +  +  +++H   E  L A  + +  LE+ G+       L  VN          
Sbjct: 601  Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642

Query: 797  RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856
                                          +  + +    + +   ++ L    +L+  +
Sbjct: 643  -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673

Query: 857  LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914
            L EA     F  +  +++LWL +    L       D   V  L+ ++ L    +A  +  
Sbjct: 674  LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733

Query: 915  WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974
               ++  A Q +     ++  I+++QE L  R+  L+     +  +LA S+ +    ++ 
Sbjct: 734  IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793

Query: 975  GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
               +  +R+      +   G      ++     Q  Q +    E R+  +      + E 
Sbjct: 794  EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
            G+  ++ ++ ++  L    + ++ + +QR +   ++   Q +  ++ +   W    +  +
Sbjct: 854  GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913

Query: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
             S +   D  SA+ LL++H+ L+ ++  +   +Q L  Q+Q       P   E       
Sbjct: 914  GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967

Query: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207
                G+EL +     Q+     + ++K     D  T   + ++ W  +   D  G     
Sbjct: 968  ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019

Query: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265
             +  L   +   R  LL   G  + ALR             A +V  +++ ++  +  L 
Sbjct: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077

Query: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320
               E+R+  L  S +     ++  EL QW+ EK      E  GA    ++ L++      
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137

Query: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357
               +A ES L    +  E L+  G           +E+    P  + D +T         
Sbjct: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197

Query: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408
                      ++ L  +W +L +   ER   L  A + ++  R   + KE +E+   AL 
Sbjct: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257

Query: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467
            +   G DL S Q LQ++H+  E +   L  K+ +L   A  +  S P   E+ Q+    L
Sbjct: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317

Query: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
                  L  R  Q +A    S +L +F       +SW+       S     + + GA++L
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377

Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
              +H+E + E+ A  G  Q     G+ L A GH  +  I ++   L+   A+LE+A   R
Sbjct: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437

Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
               L Q +  Q +  D  + E W+  +   +++ D G    +   LI KH+   + + + 
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497

Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701
               +  L   A  L       +  +   R  + ++ R L+     +  +L  +  L +F 
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557

Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEH-----ALHLCTKFAKFQHQVEMGSQRVAACR 1756
            R+ ++++ W++ + Q A   +   +DP +      L    K   F+ ++   + R+    
Sbjct: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615

Query: 1757 LLAESLLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEV 1814
             +  SL+ERG  AG    V+ R   L   W  L + +  +   L++       +  + + 
Sbjct: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675

Query: 1815 LTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPG 1873
               + E +A     +  +DL  +   L+ HQ LE ++   E +L++L   A  +      
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSA 1734

Query: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933
                 V+ ++  +   +  ++     RRA+L  +  L +F   + D  SW    +  +  
Sbjct: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGS 1794

Query: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993
            E+  ++ +        H+ L AEL A E   Q     G++         +E+Q+ L    
Sbjct: 1795 EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1854

Query: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053
            +   ++ Q  A + +RL+   + Q F+      E  +  +   + +   G ++  ++ L+
Sbjct: 1855 EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1914

Query: 2054 RKHEVFLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRG 2107
            +KHE F    T  +D+           +++       +  ++  L  +   +++ A  R 
Sbjct: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974

Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-H 2166
              L  +     F   A   E WI      LK      DL      L K + F+A +QA  
Sbjct: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034

Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN----- 2221
            +E + ++    + LLA  H ++  +  R   L K W  L    A R ++L + ++     
Sbjct: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094

Query: 2222 ---FLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
               FL F ++     +W +  E  +        LE    LR     FR + +      A 
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQAD 2151

Query: 2279 IRSISDLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLR 2320
               +++L  Q+K+     +P         EE      KII +R  +L         N   
Sbjct: 2152 FNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKL 2211

Query: 2321 YQQQLEGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
             Q+  + A   H   +E    L + +  ++E   L   L+  K         RKH+    
Sbjct: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ---- 2258

Query: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALH 2435
            E+  +++Q++ +E ++G   + +    +    H    +A+ W QL     + +  L+   
Sbjct: 2259 EIRAMRSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317

Query: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486
            QA+    + +E L     +    D   + R           HQE K+ L S
Sbjct: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2359



 Score =  289 bits (740), Expect = 3e-77
 Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)

Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
            +ELS+L       + +L+ +   Q F    E++E+W+  K    + E   DP   ++  L
Sbjct: 30   KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82

Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
             KH+  E +++  +G I  L+ T   +   GH  +++   R   +  + E L  +   + 
Sbjct: 83   QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142

Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699
             +L + ++L  +L++ ++V  W+ +K  +   E L         LQK+ + FQ ++ A  
Sbjct: 143  IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202

Query: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759
             +  E+ +   +L+Q  HP  E I+ + +E+ A W  L+  + ++  KL  A E  R  R
Sbjct: 203  ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262

Query: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815
             ++E  +W++  E  + +   G+ L  V  LL    G +R+L A  DK     +AL  +A
Sbjct: 263  DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318

Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875
                +     A  ++ +   L+  ++ +R    ER   L     L +F  D  +  +WV 
Sbjct: 319  DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378

Query: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
            E   L  A +    ++    L ++HQ  + E+ +HE   +    +G  L+ AGH+A+ EV
Sbjct: 379  EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438

Query: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995
              ++  L +  A L      RR   +Q  + Q F  +  +  +W++++   L +ED+G S
Sbjct: 439  REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498

Query: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055
             ++ +ALL++ E  ++ L A   +I  L + A  L    +     V  +  A+      L
Sbjct: 499  LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558

Query: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115
              RA  R   L +   L Q  R++  L +W+  K  TA  + Y +D   ++   +K  AF
Sbjct: 559  HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617

Query: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175
              E+ S  Q+++ AL K    L          + A+ + + + W++L +A + +   L  
Sbjct: 618  EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676

Query: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235
            A++   F +   +++  + E    +  +D G  L++V+ LQ++H  LE ++ A +  +  
Sbjct: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736

Query: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
            +  +A +           + K QEA    +  L+     R Q LA + +        ++ 
Sbjct: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796

Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
              W +E++ +A+S    +D+ G + LL +H+ L  EI     + + + Q+G  +V+  HF
Sbjct: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856

Query: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
             + +V   L EL  + + L+   + R Q   +S   Q+      +AE+W+   E ++   
Sbjct: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916

Query: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464
            DYG      E LL +H+ L   L+A       +++        + P + + G+
Sbjct: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969



 Score =  268 bits (684), Expect = 1e-70
 Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)

Query: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674
            A+    R Q +L R       +  RR +LE+  + Q F +D++E+  W++EK  +A +E 
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
              D   L  +LQK Q F+AE+ A+     +L   G  ++  GH ASE I+ RL EL   W
Sbjct: 72   YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
              L +  ++K  KL +A + ++  R  E++ +W+   E  + +  +GQ L  V  L    
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851
             E +  +     +   +   A   ++E H    L +  +++     QR K L     +R+
Sbjct: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248

Query: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
              L   + + +F RD DE ++W++EK  L A+ D+G+ L++V+ L  +H+ LE ++++ E
Sbjct: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
               + +     +L Q+   +A ++  + ++L      +R  AA R   L  +   Q+FL 
Sbjct: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368

Query: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031
            +  +  SW+ E   +++++++       +ALL R +  K +++A     +   ++   L 
Sbjct: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428

Query: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091
            +  +  S +V  +L  + E  A LL   E R    ++ + L    R+T  +D W++ + A
Sbjct: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488

Query: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151
               ++D G  L+ V+ L +K + F K + S  + K+ AL + A  L +        +  +
Sbjct: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547

Query: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
            R  + +    L +    R   LA +  +  F + + EL+  + EK      ++     S+
Sbjct: 548  RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606

Query: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267
            ++   Q+H+  E EL A +  +  L+    +L  ++  A   +A    +V   W  L   
Sbjct: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327
             + +G  L +A Q   F    +++  W  E +   +S++  +D+   + L  +H  L  +
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726

Query: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387
            +   + +   +  + +Q  D  HF +  + +  + L  R + L+E    R Q+ A+S  L
Sbjct: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786

Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
            Q+L + +E  E W+   E +    + G  +  V+ LL +HQ L+  +A  E +
Sbjct: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839



 Score =  223 bits (569), Expect = 2e-57
 Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
            A ++  R QQ+       +  +  RR  L+ +   Q F  +  E   W+ E+  +   E+
Sbjct: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
                    Q  L++ +A + +++A S  I +L +T  L+ S  +  S  +  +L  +   
Sbjct: 72   YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130

Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
               LL +   +G  L +  +L Q  RE   +  W+  K A   S++ GQDLE V+VL++K
Sbjct: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190

Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
            F+ F+ ++ +  + +V  + + A  L +        I+ ++  + AAW+RL      R  
Sbjct: 191  FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249

Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
             L  A EV  F +   E    ++EK  LM  +D G  L+SV+ L ++H  LER+L A+E 
Sbjct: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309

Query: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287
            +V  L  EA RL Q HP +   +   +E     W  ++  A ER   L  + +   FL  
Sbjct: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369

Query: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
             ++L +W  E + L +++ELA DVAGAE LL +H+E   EI       +   + GQ L+ 
Sbjct: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429

Query: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407
              H+ S EV E L  L      L E W LR Q+  +   LQ   +  EQ + W++  E  
Sbjct: 430  AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489

Query: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
            LL  D G S+  VE LL +H+D EK L+AQEEK   + +
Sbjct: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528



 Score =  127 bits (320), Expect = 2e-28
 Identities = 137/569 (24%), Positives = 246/569 (43%), Gaps = 34/569 (5%)

Query: 206  AFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQ 265
            A  V E+++   Q    + +AA    +  I +  +       RL + Q +++R      +
Sbjct: 1493 AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL-KAQMIEKRS-----K 1546

Query: 266  LQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRL 325
            L E++ LQ Q+ + V ++  WI+EK        + D  P   QL    +         + 
Sbjct: 1547 LGESQTLQ-QFSRDVDEIEAWISEKLQTASDESYKD--PTNIQLSKLLS---------KH 1594

Query: 326  QQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ---QR 382
            Q+  A EA L      ++       +   G  L E   C AG E A  AR  AL    Q 
Sbjct: 1595 QKHQAFEAELHANADRIRG------VIDMGNSLIERGAC-AGSEDAVKARLAALADQWQF 1647

Query: 383  LLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS------LATVEAAVQRLGM 436
            L+Q    ++   +  +K     + +KD +  L +  A  AS      LA+V   +++  +
Sbjct: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1707

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            LEA I   E R + L   AD L        + V  +++ +  R+Q++      +R ++ +
Sbjct: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767

Query: 497  MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556
               +    ++++     ++E +    S   G+ L  V  L ++H  LEA+++AH   +  
Sbjct: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827

Query: 557  LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
            +     +L        E +Q +     +  + L  L  AR   LE++L+  +F+ N EEE
Sbjct: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887

Query: 617  EAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPP 676
            EAW+ E    V +   G  L+ I G L+KH+A E +   H+    D+   G+DL  +   
Sbjct: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947

Query: 677  TQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA 736
             + +   + + + G    L+     R A+L      LQ+   A    SW+ E+ +SL+  
Sbjct: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007

Query: 737  SCGQDQAAAETLLRRHVRLERVLRAFAAE 765
              G+D ++ +TLL +    +  L+AF  E
Sbjct: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQE 2036



 Score =  123 bits (309), Expect = 3e-27
 Identities = 211/1120 (18%), Positives = 440/1120 (39%), Gaps = 125/1120 (11%)

Query: 376  SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426
            ++ LQ++  +L Q   +L +R  Q KA L +S     FL D   ++         +++  
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366

Query: 427  -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479
                    EA ++R       I  + G FQA  +    L    +++  ++ +++ ++  +
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425

Query: 480  WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
             +  L+    QR+ + D    L L  ++ E A + +   +    +   G  L  V  L++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485

Query: 539  RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
            +H+  +  ++     ++ L     +L ++   +   + ++   +    + L A +  +R+
Sbjct: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545

Query: 599  LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL----GRDLSQIAGALQKHKALEAEVH 654
             L ++    +F R+ +E EAW+ E  Q   + +        LS++    QKH+A EAE+H
Sbjct: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605

Query: 655  RHQAVCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLV 712
             +      ++  G  L  R      +   +A   A+   WQ L  +   +  +L+ A   
Sbjct: 1606 ANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ 1665

Query: 713  LQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
              +     +   WL E  + L     G+D A+   LL++H  LE  + A    L+ L  Q
Sbjct: 1666 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725

Query: 773  GRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTI 832
                    SL T ++                                       FD + +
Sbjct: 1726 AD------SLMTSSA---------------------------------------FDTSQV 1740

Query: 833  LQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD 892
               +D ++  ++ ++++A  RRA+L E+  L  F     + + W++++ +L+       D
Sbjct: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800

Query: 893  TLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQL 950
               V  L  K++     LA  +     V  + ++L         +IQ++  +  + W +L
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860

Query: 951  EALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT 1010
            + L   +  +L  S+E   F+      +  + + +  + +   G   DT  A+Q   KK 
Sbjct: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKH 1917

Query: 1011 LVLER-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQ 1063
               E        RV+ + +    + +      + +  +++ L G +  +++  AQR  + 
Sbjct: 1918 EAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKL 1977

Query: 1064 AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QER 1122
             E  A   F  ++  +  W    +  L++ +   D++S Q LL + +     +  + QE 
Sbjct: 1978 DENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037

Query: 1123 LQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREV 1182
            +  + A    + A     S+ +      L ++  +L      R++ L   LE Q   R+V
Sbjct: 2038 IANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKV 2094

Query: 1183 DGFTATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEA 1231
            +    T A   +  +   +N  ED         + E  +L + H  F   LS+       
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154

Query: 1232 LRAHGEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQL 1281
            L A  ++ ++S   A++      +++++  W  LQ          + EQRR++    L+ 
Sbjct: 2155 L-AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR- 2212

Query: 1282 QEWKQDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
            QE+ Q      QW++E            E SG   + L+  KR      E+ A R  ++ 
Sbjct: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKK 2269

Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
            ++ +G  +        +  +    GL  +W+ L++        L+Q  Q        ++A
Sbjct: 2270 IEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA 2329

Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436
             ++   +       ++G         +  HQ+ +S  R+L
Sbjct: 2330 LKEFSMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2360


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score =  567 bits (1462), Expect = e-161
 Identities = 512/2247 (22%), Positives = 965/2247 (42%), Gaps = 112/2247 (4%)

Query: 1156 QELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQH 1215
            Q  K    +R Q L++   LQ F R+ D         +  +  D   ED        Q+H
Sbjct: 36   QSFKERVAERGQKLEDSYHLQVFKRDADDL-GKWIMEKVNILTDKSYEDPTNIQGKYQKH 94

Query: 1216 REFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL 1275
            +     + T       L    E+     H A    +  ++ ++  W  L   + ++  QL
Sbjct: 95   QSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQL 154

Query: 1276 LASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHV 1334
            L +L+ Q++ Q+ A++++W+ +K  +A     G      + L K+ E  + EL+A    V
Sbjct: 155  LRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRV 214

Query: 1335 EALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQ 1394
              + Q   E           IQ++   + + WE L     +R   L  A   ++  R + 
Sbjct: 215  VEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVT 274

Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS- 1453
            +A + +++ E  L S + G+DL +S+ L   H+ LE     ++ K+  L + A  +  S 
Sbjct: 275  EAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH 334

Query: 1454 ----PAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGS 1509
                P I E  +  +   E ++     R  +LQA+   H+F    +    W+ E     +
Sbjct: 335  PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAIN 394

Query: 1510 PTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQEL 1569
                   + G + L  +H++ + E+ ++  + Q    +G+ L  + H  +  + E+ + L
Sbjct: 395  ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEIL 454

Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRL 1629
            + +W  L    + R +  +Q + F  ++ D  +++ W+  +   + + D G    +   L
Sbjct: 455  DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEAL 514

Query: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV--VQERLREQLRALQELAATR 1687
            + KH+  +E        +  +D+TA  L G +  + + +  +++ L  +  AL+E AATR
Sbjct: 515  LQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             R L+ +L L +   +++DL+ W+  +K+ A   +   +D ++      K   F+ ++ +
Sbjct: 575  RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAV 632

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
               ++   +   + ++E GH A   V  R  ++ + W EL E T+ +G  L +    L+ 
Sbjct: 633  NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF 692

Query: 1808 HR---DLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETA 1864
                 DL   L  V+ + TS   +  + L  ++ +LR H  LE  +   + Q+  L + A
Sbjct: 693  ENNAEDLQRWLEDVEWQVTS--EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750

Query: 1865 GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWA 1924
               +++   P +  ++ RQ+++   +  L+  +  R+ +L     L        D  +W 
Sbjct: 751  AYFEEI-GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWI 809

Query: 1925 ARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE 1984
                         ++  +    L+ H+ +   + + E   Q+ T+ G + +       ++
Sbjct: 810  QETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAED 869

Query: 1985 VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGS 2044
            V   +++L    + +    AR+Q  L+A  Q Q +L +    E  +  +E  +  +  G+
Sbjct: 870  VASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGA 929

Query: 2045 SVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
              E    L++KHE FL  L +      ALR +    ++ +      +  ++R+      +
Sbjct: 930  DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQ 989

Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
            +R             T  ++  +DW +  A   +  VP   +R      L H  F    Q
Sbjct: 990  ARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRR-----LAHDEFPMLPQ 1044

Query: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN-FL 2223
               E                    G ++QR + +   +  L      R + L  R N FL
Sbjct: 1045 RRRE------------------EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086

Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
               +  D+ E WIQEK+ +    + G +L+   +L+++  EF+ +   +      I  ++
Sbjct: 1087 LAYEAGDMLE-WIQEKKAE----NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVA 1141

Query: 2284 DLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTK 2343
            D  L      PE  +I    R +LN+RW S        +Q L  A  + V  RE D+  +
Sbjct: 1142 DDLLFEGLLTPEGAQI----RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKE 1197

Query: 2344 RIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
            +I++K   + A D G DL SVQ L R+HE  ER++ P+  +V  L     RL +  P+A 
Sbjct: 1198 QIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDAT 1257

Query: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDA-------LHQAQKLQAMLQEL--LVSAQRL 2454
              L+ ++ E+ E+W  L+ R + R+E+L+        L +A+ LQ  +  +  +VS+Q L
Sbjct: 1258 EDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQEL 1317

Query: 2455 RAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQ 2514
               +       + +E   +LE HQE +A++++   +         +L+ +GH  S +I +
Sbjct: 1318 AEDL-------TGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEK 1368

Query: 2515 VLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLA 2574
             L  ++ E   LE AW++ +  L Q LELQ+F  + +++E W+ ++E+SL S+     L 
Sbjct: 1369 KLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLD 1427

Query: 2575 PMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
             +E L+ K   L+  +  Q GKI+ LE  A  L    H   +    R Q +L R +AL  
Sbjct: 1428 SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA 1487

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAE 2694
            Q    R +L +   L+ F +D +E+  W+ E    A +E   D   +  +  K Q F  E
Sbjct: 1488 QLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHE 1547

Query: 2695 LDASMHQQQELQREGQRLLQGG--HPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
            +D    Q   +   G  L++        EA++E+LE+L   W  L + +  K  KL +A 
Sbjct: 1548 VDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEAS 1607

Query: 2753 EALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALL 2812
               R   S+ + E WL   E  L      + L   G LL   + LE  +  +    + L 
Sbjct: 1608 RQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLN 1667

Query: 2813 GQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
              A+  +  G      + ++   + +RF +++E        L+    L +FF+D D+E +
Sbjct: 1668 TLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES 1727

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
            W++EKL   ++QDYG+ L  V++L ++H+ LE E+ +HE   + VL    KL        
Sbjct: 1728 WIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
             E+  R+ Q  +    L+  A  R L L+++ E  QF+    E  +W+ E+  +    D 
Sbjct: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDC 1847

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERL-QQTAALLES--RKNPESPKVLAQLQAVR 3049
            G +  ATQ+LL + EA + D      R++ +  Q   +L    ++  ++ ++ ++++A+ 
Sbjct: 1848 GDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN 1907

Query: 3050 EAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLE 3109
            E    L +   A    L++     +   +  +++AW+  K  + ++   G DL     L 
Sbjct: 1908 EKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLL 1967

Query: 3110 EKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKAR 3169
             K D     +QS  Q ++  +  L   L      +   I+ + + +   WE+L +A    
Sbjct: 1968 AKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVH 2027

Query: 3170 TENLAA---------------AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRT 3214
             + L                 AH+  +      +++  + E    +       SL+ +R 
Sbjct: 2028 RQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCV-------SLNEIRQ 2080

Query: 3215 LQQQHRRLEREL---EAMEKEVARLQTEACRLGQLHPAAPGGLAKV---QEAWATLQAKA 3268
            LQ+ H      L   +A  K +  L  +   LG   P++P     V   +  W  L    
Sbjct: 2081 LQKDHEDFLASLARAQADFKCLLELDQQIKALGV--PSSPYTWLTVEVLERTWKHLSDII 2138

Query: 3269 QERGQWL-AQAAQGHAFLGRCQE-------LLAWAQERQELASSEELAEDVAGAEQLLGQ 3320
            +ER Q L  + A+       CQE        L W  E +       L ++    E  L  
Sbjct: 2139 EEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEA 2198

Query: 3321 HEELGQEIRECRLQAQDLRQEGQQLVD 3347
            ++   +EI+  + Q   +   G  L D
Sbjct: 2199 NKRKQKEIQAMKRQLTKIVDLGDNLED 2225



 Score =  556 bits (1433), Expect = e-157
 Identities = 400/1444 (27%), Positives = 684/1444 (47%), Gaps = 96/1444 (6%)

Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL--KEPVP 2142
            +++R   +L R    KE    RG  L  S  +  F + A     WI      L  K    
Sbjct: 24   IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYED 83

Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
            P +++ K +   KHQ+ EAEVQ    +M+ + K  E      H    E    ++ LR  W
Sbjct: 84   PTNIQGKYQ---KHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140

Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
            + L +    +G +L     F +++Q       WI +KE      +LG+D E    L ++ 
Sbjct: 141  DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200

Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
             +F+         +  +  ++  + +    +  ++ +I  +++++N  W    G  L+ Q
Sbjct: 201  EDFQVELVAK---EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257

Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
            + L  A  +    R++    + I+EKE ++ + D GKDL + + L   H+ LER +  + 
Sbjct: 258  KALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMS 317

Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
             +V+ L  +  +L    P  A  ++  ++++  SW  +R+ A  R E L A +   +  +
Sbjct: 318  DKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377

Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
               EL        A ++    P        +L+ HQ+ K E+DS+ D    A  TGQ L+
Sbjct: 378  DFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLV 437

Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
             A H  S ++R+ +  L+   ++L   W E   Q +Q L+  LF    E+++ W+  +E 
Sbjct: 438  NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497

Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
             L +E L + L   E LL KH+  E     Q  KI  ++ TA  L    H ++++     
Sbjct: 498  FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557

Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
              +L R++AL  +A TRR  L+E   LQ   +DS ++  W+ +K  +A +E   D   L 
Sbjct: 558  DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617

Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
            +++QKQQ F+ EL  +  Q + +Q+ GQ +++GGH AS+ +  RL E+ +LW EL + ++
Sbjct: 618  SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677

Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
            +K  +L +A + L+   + E+L+ WLE +E ++ +   G+ L  V   L     LE+AV 
Sbjct: 678  QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737

Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
             +  Q + L   A  F   GH  ++D+  +   L+ RF++L+EPL  R+  L     L  
Sbjct: 738  ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797

Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
              RD ++E AW+QE  P A +   G+ L A + L  +H+ +   ++SHE   + +   G 
Sbjct: 798  ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
            K+V+ GHFAA +VA+RV+ L + M  LRA AARR+  L+   + QQ+L +L EA +W+ E
Sbjct: 858  KMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE 917

Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERL--------QQTAALLESRK 3034
            +  ++D+ + G   EA  ALL++ EA   DL +F   ++ L        QQ AA +E   
Sbjct: 918  KEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVA 977

Query: 3035 NPE-----------SPK--------VLAQLQAV----------------------REAHA 3053
              +           SP+        VL  L ++                      R AH 
Sbjct: 978  GEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHD 1037

Query: 3054 EL----LRRAEARGHGLQEQLQLHQL---------ERETLLLD---------------AW 3085
            E      RR E  G+  Q Q Q+            ER   LL                 W
Sbjct: 1038 EFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEW 1097

Query: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
            +  K A    ++ G +L+ V  L++KFD F+K++ +  + ++  + K+A  L        
Sbjct: 1098 IQEKKA----ENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDL-LFEGLLT 1151

Query: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDG 3205
            P     R  + + W  L +    + + L +AH V  F + A + + ++++K   +   D 
Sbjct: 1152 PEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211

Query: 3206 GHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK----VQEAW 3261
            G  L SV+ LQ++H   ER+L  +  +V  L   A RL + HP A   L +    + EAW
Sbjct: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271

Query: 3262 ATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQH 3321
              LQ + ++R + L +A + + FL + ++L  W      + SS+ELAED+ G E LL +H
Sbjct: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331

Query: 3322 EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRC 3381
            +E   ++       Q L     +L+D+ H  S E+ + LQ ++    +LE+AW  R +  
Sbjct: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391

Query: 3382 AESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKF 3441
             +   LQ  +   +Q E+W+   E   L+ D   S+  +E L+ +  DL+K + AQE K 
Sbjct: 1392 DQCLELQMFQGNCDQVESWMVAREN-SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKI 1450

Query: 3442 AQMQ 3445
              ++
Sbjct: 1451 TDLE 1454



 Score =  448 bits (1153), Expect = e-125
 Identities = 492/2299 (21%), Positives = 941/2299 (40%), Gaps = 217/2299 (9%)

Query: 683  ERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
            ER + V   +Q  + RV  RG +L+ +  +  +  DA +   W+ E+ + L   S  +D 
Sbjct: 26   ERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-EDP 84

Query: 743  AAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPW 802
               +   ++H  LE  ++  +  +  LE+       R   FT+  +              
Sbjct: 85   TNIQGKYQKHQSLEAEVQTKSRLMSELEK------TREERFTMGHSAH------------ 126

Query: 803  SEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMA 862
             E   H                        ++   HL   ++ L  L   +  +L  A+ 
Sbjct: 127  EETKAH------------------------IEELRHL---WDLLLELTLEKGDQLLRALK 159

Query: 863  LFGFCSSCGELQLWLEKQTVLLQRVQPQAD--TLEVMQLKYENFLTALAVGKGLWAEVSS 920
               +   C ++  W+  +  +   V+   D    EV+  K+E+F   L   +G   EV+ 
Sbjct: 160  FQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ 219

Query: 921  SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
             A +  +    +   IQ +Q E++  W +L  L  ++   L+++  +  F ++       
Sbjct: 220  YANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQW 279

Query: 981  LRDVLLQLEALQPG----SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
            +++    L +   G    +SE   H+ +  ++   V+  +V  L +   K+     +++ 
Sbjct: 280  IKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAP 339

Query: 1037 PLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVS 1096
             +Q   E L    + ++     R  +   T     F  +  +L  W     A + + E+ 
Sbjct: 340  QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELP 399

Query: 1097 VDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
             DVA  + LL  HQ    EI  + +R Q  D   Q +   +   S EV   + +L     
Sbjct: 400  TDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWT 459

Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHR 1216
             L  LW++R +  ++ L+   F R+ +   +  +  +A+L  ++LG  +  A +LLQ+H 
Sbjct: 460  ALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
            +F    +    +   +     KL+   H  +  ++     + A+   L+ ++  RRR L 
Sbjct: 520  DFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLK 579

Query: 1277 ASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
             SL LQ+  +D  +L  W+ +K  +A  E     +N+   +++ +  E EL   +  +E 
Sbjct: 580  ESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLEN 639

Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
            +Q+ G+E++       +++ TRL  + S WE L     ++G +L +A QQ Q     +D 
Sbjct: 640  IQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDL 699

Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAH-----GMA 1451
            +  LE +E  + S + G+ L   Q   ++H  LES       ++  L  +A      G  
Sbjct: 700  QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP 759

Query: 1452 ASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             S  I    +  + R E L+  LA R  +L   + L   C  +  E +W+ E  P  + T
Sbjct: 760  DSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATST 819

Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
               + L  ++ L  +H+ +   + +H+ ++Q +   G  +   GH  A+ +  + + L  
Sbjct: 820  YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879

Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
            +   L      R   L+  V FQQY  D+ E E W+ EK P+V + +YG DE A   L+ 
Sbjct: 880  NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLK 939

Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL 1691
            KH+A   +L  +  SM+ L   A      +    + V  E   +++ AL +  A   RE+
Sbjct: 940  KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGE---QRVMALYDFQARSPREV 996

Query: 1692 EGTLRLHEFLR------------EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
              T++  + L             EA D QG + +        +     P+          
Sbjct: 997  --TMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNIT 1054

Query: 1740 KFQHQVEMGSQRVA-ACRLLAESLLER------GHSAGPMV----RQRQQDLQTAWSELW 1788
            + Q Q+E   + +          LL+R       + AG M+     ++ ++      ++W
Sbjct: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114

Query: 1789 ELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLER 1848
            EL +      +D  T     RD+ +V   +  +    P         +  +L S  G  +
Sbjct: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ-----IRQELNSRWGSLQ 1169

Query: 1849 ELVGTERQL-----------QELLETAGRVQKLC-------PGPQAHAVQ---------- 1880
             L   +RQL           +E  +T  +++K C       PG    +VQ          
Sbjct: 1170 RLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE 1229

Query: 1881 -------------------------------QRQQ-AVTQAWAVLQRRMEQRRAQLERAR 1908
                                           QRQ+  + +AW  LQ R + R+  L  A+
Sbjct: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289

Query: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
                F +  RD  +W + +   +  +E +++ +   + L  HQ  RA++EA    +Q   
Sbjct: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349

Query: 1969 QLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE 2028
                + + +    + E++++L+A++ +RD + + W ++++ L    + Q+F   C ++E 
Sbjct: 1350 DFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVES 1409

Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------RR 2082
             + A+E SL++    SS++ +E L++K +   K +TAQ+ K   L    ++L       +
Sbjct: 1410 WMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAK 1468

Query: 2083 PRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
              +  RL  +L R   +K         L     +  F +   + E+WI        E +P
Sbjct: 1469 EEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWI-------SEMLP 1521

Query: 2143 PG------DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE--VSQR 2194
                    D  +  +  LKHQ F  EV    E +  V   G +L+  S     E  + ++
Sbjct: 1522 TACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581

Query: 2195 LQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEH 2254
            L+ L++HW+ L +    +G++L +      F   +   E W+ E E  + + D  +DL  
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641

Query: 2255 CLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASF 2314
               L   L++ +         +  ++ ++ L+  L +     V  I +++  +N R+ + 
Sbjct: 1642 AGNL---LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNV 1698

Query: 2315 HGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL 2374
                  + ++L+ A  +    ++LD+    I+EK   + + D G+DL+ VQ LL+KH+ L
Sbjct: 1699 QELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRL 1758

Query: 2375 EREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR------- 2427
            E E+   +  ++++     +L  ++      ++ R  +  E W +L+  A+ R       
Sbjct: 1759 EGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEES 1818

Query: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487
             E L  +  A++ +A + E    A R     DT  A +S      +L +H+  + +    
Sbjct: 1819 LEYLQFMQNAEEEEAWINEKNALAVRGDCG-DTLAATQS------LLMKHEALENDFAVH 1871

Query: 2488 TDSISLARSTGQQLLT---AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQ 2544
               +    + G+ +L         + +I   +  L ++  SL  A    +LQL+     Q
Sbjct: 1872 ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ 1931

Query: 2545 LFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEAT 2603
             F    + +E W+  KE SL + G    L     LL K   L+  L+  Q  ++  +   
Sbjct: 1932 EFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDL 1991

Query: 2604 ARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWL 2663
               L    H ++++   R  A+L R E L   +   R +L E +QL   LQ ++++    
Sbjct: 1992 KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLE-KQLP--LQKAEDLFVEF 2048

Query: 2664 REKNLV------ALEEGLLDTAMLPA-----QLQK-QQNFQAELDASMHQQQELQREGQR 2711
              K          +EE L +     +     QLQK  ++F A L  +    + L    Q+
Sbjct: 2049 AHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108

Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPI 2771
            +   G P+S      +E L   W  L D  +++  +LQK  E  R  ++ E  + + +  
Sbjct: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK--EEARQVKNFEMCQEFEQNA 2166

Query: 2772 EVELRAPTVGQALPGVGELLGTQRELEAAVD---KKARQAEALLGQAQAFVREG----HC 2824
               L+     +A    G LL     LE+ ++   +K ++ +A+  Q    V  G      
Sbjct: 2167 STFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDA 2226

Query: 2825 LAQDVEEQARRLLQRFKSL 2843
            L  D++     L Q++  L
Sbjct: 2227 LILDIKYSTIGLAQQWDQL 2245



 Score =  431 bits (1108), Expect = e-120
 Identities = 420/1905 (22%), Positives = 814/1905 (42%), Gaps = 74/1905 (3%)

Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
            A+ I E+ QE+   +   +     R Q L+ +   Q +  D  +L  W+ EK  +++ + 
Sbjct: 21   AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80

Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQT--LTGPEVPEQQRVVQERLREQ 1676
            Y  D         KHQ+L+ E+      M EL++T +     G    E+ +   E LR  
Sbjct: 81   Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139

Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
               L EL   +  +L   L+  ++++E  D+  W+  ++  A   E LGED E    L  
Sbjct: 140  WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVE-LGEDWERTEVLHK 198

Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
            KF  FQ ++     RV      A    E  H   P+++ +Q ++  AW  L  L   R  
Sbjct: 199  KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258

Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTER 1855
            AL +     R  RD+ E +  ++EK   L + +  +DL   E    SH+GLER L     
Sbjct: 259  ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318

Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
            +++EL   A ++    P   A  +Q+ ++ +  +W  ++     R  +L+      RF +
Sbjct: 319  KVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377

Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
               + + W       +  +E   + + G + L  HQ  + E+++ +  +Q A + GQ  +
Sbjct: 378  DFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLV 437

Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
             A    + EV+E++  L +    + + W  +  + +      LF R+  +++  ++ QE 
Sbjct: 438  NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497

Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPI---- 2091
             L+   LG+S+   E L++KHE F +  TAQ++K   + +    L      D   I    
Sbjct: 498  FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557

Query: 2092 --LLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDK 2149
              LL RR  ++E A +R   L  SLL+    + +   ++WI    ++L +     D+++ 
Sbjct: 558  DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNL 616

Query: 2150 LKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM 2209
               + K Q FE E+  ++  + ++ K G+ ++   H  +  V+ RL  +   WE+L +A 
Sbjct: 617  KSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676

Query: 2210 ALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNS 2269
              +G +L +    L+F    +  + W+++ E ++   D G+ L    +++ RLR+     
Sbjct: 677  KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA---EVQNRLRKHGLLE 733

Query: 2270 AGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL 2329
            +        +  ++DL+   +     + K I  R+  L  R+ +    L   +++L   L
Sbjct: 734  SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793

Query: 2330 EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLE 2389
             + ++ R+ ++    IQE E    +   GKDL + ++LL +H  +   +   + +++ + 
Sbjct: 794  HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853

Query: 2390 REVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449
                ++ +    AA  +  R + + ++   LR+RA +R+  L+A  Q Q+  A L E   
Sbjct: 854  ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913

Query: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFS 2509
              +     +D +        A  +L++H+    +L+S+ DS+   R+             
Sbjct: 914  WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN------------- 960

Query: 2510 SDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGL 2569
                Q  A  +Q+ + +EG   E ++       + L+             K D L     
Sbjct: 961  ----QANACQQQQAAPVEGVAGEQRV-------MALYDFQARSPREVTMKKGDVLTL--- 1006

Query: 2570 WDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARG-LHQGGHPEAQSALGRCQAMLLR 2628
               L+ +    WK +  +    V A  +  L       L Q    E  +   R + +  +
Sbjct: 1007 ---LSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ 1063

Query: 2629 KEALFRQAGTRRHRLEELRQLQAFL--QDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQ 2686
              +L  +A  RR RL  L++   FL   ++ ++  W++EK        L D   L    +
Sbjct: 1064 YRSLLDRAEERRRRL--LQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQ---K 1118

Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVA 2746
            K   FQ +L+ +  + +++ +    LL  G    E  Q R +EL + WG LQ  + ++  
Sbjct: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNSRWGSLQRLADEQRQ 1177

Query: 2747 KLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVD 2802
             L  A       R  ++ +  +E     L A   G  L  V  L     G +R+L    D
Sbjct: 1178 LLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237

Query: 2803 KKARQAEALLGQAQAFVREGHCLA-QDVEEQARRLLQRFKSLREPLQERRTALEARSLLL 2861
            K       +LG+    + E H  A +D++ Q   L + ++ L+   ++R+ +L       
Sbjct: 1238 KVT-----ILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFY 1292

Query: 2862 KFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTG 2921
             F   A +   W+     + ++Q+  + L+ +  L E+HQ   ++M +     + +    
Sbjct: 1293 LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFS 1352

Query: 2922 YKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLA 2981
             +L+ +GH A+ E+  ++Q ++     L     +R+ +L Q  E Q F     +  SW+ 
Sbjct: 1353 AELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMV 1412

Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
             R + L S+D   S ++ +AL+++ +   + + A   +I  L+  A  L + ++    ++
Sbjct: 1413 ARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI 1471

Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
              +LQ V +    L  +       L +   L Q  R+   L+ W++    TA  + Y +D
Sbjct: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KD 1530

Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER--GAPRRYPHIQAQRSRIEAAW 3159
               ++    K   F  EV    + +V+ +  L  +L            ++ Q  +++  W
Sbjct: 1531 ATNIQRKYLKHQTFAHEVDGRSE-QVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589

Query: 3160 ERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQH 3219
            + L +    + + L  A     F  +  + +  + E   L+  +D    L+S   L ++H
Sbjct: 1590 DHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKH 1649

Query: 3220 RRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWL 3275
            + LERE+ A E  +  L T A  L          + K    V + +  +Q  A    + L
Sbjct: 1650 QLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709

Query: 3276 AQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQA 3335
             +A     F     +  +W +E+    SS++   D+ G + LL +H+ L  E+       
Sbjct: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769

Query: 3336 QDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLE 3395
            Q++    ++L D +     E+   L +     ++L+E    R  +  ES    +  Q  E
Sbjct: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829

Query: 3396 QAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
            + EAW+     L ++ D G +++  + LL +H+ LE   A  E +
Sbjct: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874



 Score =  391 bits (1005), Expect = e-108
 Identities = 375/1676 (22%), Positives = 707/1676 (42%), Gaps = 111/1676 (6%)

Query: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
            +  +++ VQ+  + E  +   + + + + +    + +  +++  +V  R  EV   W+ L
Sbjct: 613  IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL 672

Query: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
            L+  + +  Q+ +    L      E     LE+++    S   G+ LAEV   L++H LL
Sbjct: 673  LEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLL 732

Query: 544  EAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQT 603
            E+ V+A    V  L    A  +       + ++A+  +L    ++L   +  R+  L   
Sbjct: 733  ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792

Query: 604  LQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDL 663
            L      R+ E+EEAW++E      +  LG+DL      L +H+ +   +  H+    ++
Sbjct: 793  LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852

Query: 664  VRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAA 723
              RG  +         D   R +++    + L+ R   R   L+  +   QY AD  EA 
Sbjct: 853  TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE 912

Query: 724  SWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ----------- 772
            +W+RE+   ++  + G D+ AA  LL++H      L +F   ++ L  Q           
Sbjct: 913  TWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972

Query: 773  --GRAASARASLFTVNSALSPPGESLR-----------NPGPWS-EASCHPGPGDAWKMA 818
              G A   R        A SP   +++           N   W  EA+ H G   A  + 
Sbjct: 973  VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032

Query: 819  LPAEPDPDF-------DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCG 871
              A  +          +P  I Q Q+ +   Y SL   A+ RR RL +    F      G
Sbjct: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAG 1092

Query: 872  ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPG 931
            ++  W++++    +    + D +  +Q K++ F   L   +    +++  A+ L   + G
Sbjct: 1093 DMLEWIQEKKA--ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL--FEG 1148

Query: 932  NSTQIQRQ-QEELSQRWGQLEALKREKAVQL--AHSVEVCSFLQECGPTQVQLRDVLLQL 988
              T    Q ++EL+ RWG L+ L  E+   L  AH+VEV  F +E   T+ Q+      L
Sbjct: 1149 LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQAL 1206

Query: 989  EALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVET 1044
             A  PGS   +  ALQ      ++  + L  +V  L     ++ E     ++ LQ Q   
Sbjct: 1207 SAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266

Query: 1045 LQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQR 1104
            L    + +Q +   R     E Q    FL +++ L  W  S+   + S+E++ D+   + 
Sbjct: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326

Query: 1105 LLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164
            LL  HQ+   ++       Q L+  S  +       S E+   L+ +  +  +L+  WE+
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386

Query: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWL--HLDNLGEDVREAL----SLLQQHREF 1218
            R++ L + LELQ F          C   ++W+    ++L  D + +L    +L+++  + 
Sbjct: 1387 RKKILDQCLELQMF-------QGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDL 1439

Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
             + ++    +   L    E L+  +H A   +  +LQ +  +W  L+ +    R +L   
Sbjct: 1440 DKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDY 1499

Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQ 1338
              L+++ +D+ EL +W+ E    A  E      NI +   +H+    E+      V  + 
Sbjct: 1500 ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559

Query: 1339 QVGRELLSRRPC--GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
             +G  L+    C   +E ++ +L+ L+  W+ L  +  ++G +L +A +Q++    ++D 
Sbjct: 1560 NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDF 1619

Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA- 1455
            +  L + E  L   +  +DL S+  L K+HQ LE E       +  L ++A  + +S   
Sbjct: 1620 EFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679

Query: 1456 ----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
                I+++     +R   +Q   A    +L+ +  L QF    + E SW+ E +   S  
Sbjct: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739

Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSL---AASGHPQAQHIVEQCQE 1568
             Y   L G Q+L +KHK L+ E+ AH+  +Q VL     L   AA G  + Q  + Q  E
Sbjct: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVE 1799

Query: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLR 1628
               HW +L+   +AR   L++++ + Q+  +  E E W+ EK  L    D G   AAT  
Sbjct: 1800 ---HWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQS 1856

Query: 1629 LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ-----ERLREQLRALQEL 1683
            L+ KH+AL+ + A++ + ++ +    + +    + E+ +  +     E L E+  +L + 
Sbjct: 1857 LLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKA 1916

Query: 1684 AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQH 1743
             A    +LE      EF  +A+ ++ W+A ++ + K   + G D    L L  K      
Sbjct: 1917 IAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN-GADLGDFLTLLAKQDTLDA 1975

Query: 1744 QVEMGSQ-RVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE 1802
             ++   Q R+     L + L+   H+    + +R   L   W +L E +      L + +
Sbjct: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035

Query: 1803 TTLRVHRDLLEVLTQVQEKATSLPN-------NVAR-----DLCGLEAQLRSHQGLEREL 1850
              L+   DL     +   KA++L N       N++       L  +    + H+     L
Sbjct: 2036 LPLQKAEDL---FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASL 2092

Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERA--- 1907
               +   + LLE   +++ L   P +       + + + W  L   +E+R  +L++    
Sbjct: 2093 ARAQADFKCLLELDQQIKAL-GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151

Query: 1908 -----RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
                  +   F      +  W    R         +E  +   +L A++  + E++A ++
Sbjct: 2152 QVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKR 2211

Query: 1963 LWQQATQLG---QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
               +   LG   + AL+       +++     L  Q DQ+YQ   R Q  L+ + Q
Sbjct: 2212 QLTKIVDLGDNLEDALIL------DIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ 2261



 Score =  357 bits (917), Expect = 9e-98
 Identities = 471/2268 (20%), Positives = 900/2268 (39%), Gaps = 154/2268 (6%)

Query: 935  QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG 994
            +IQ +++E+  R+   +    E+  +L  S  +  F ++        + ++ ++  L   
Sbjct: 23   EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLG---KWIMEKVNILTDK 79

Query: 995  SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP-------GYAESQPLQGQVETLQG 1047
            S ED  + +Q   +K   LE  V     ++ ++E+        G++  +  +  +E L+ 
Sbjct: 80   SYEDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138

Query: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
            L   + E   ++  +       Q ++QE   +L W    +A   S E+  D    + L +
Sbjct: 139  LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198

Query: 1108 EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
            + +D   E+   + R+ +++  +   A  + PD   + +    +    + L+ L  QRQ+
Sbjct: 199  KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258

Query: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
             L     LQ+F R+V          +  L  ++ G+D+  +  L   H+   R L+ +  
Sbjct: 259  ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318

Query: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
            + + L A  EKL  S    A  ++E  + + + W  ++  +  R  +L A+     +  D
Sbjct: 319  KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378

Query: 1288 VAELMQWMEEK--GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
              EL  WM EK   + A   P+      +  L RH+  + E+ +     ++  + G++L+
Sbjct: 379  FDELSGWMNEKTAAINADELPTDVAGGEV-LLDRHQQHKHEIDSYDDRFQSADETGQDLV 437

Query: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEG 1405
            +      ++++ +++ L + W AL     ER  + +Q        R  +     + + E 
Sbjct: 438  NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497

Query: 1406 ALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465
             L++ + G  L S++ L ++H+  E        K+  +   A  +        E  K +R
Sbjct: 498  FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557

Query: 1466 -----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGA 1520
                 R + L+   A R   L+ S+ L +    S+   +W+ +         Y +  N  
Sbjct: 558  DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN-L 616

Query: 1521 QSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERAC 1580
            +S  +K +  + E+  ++ Q++ +  +G+ +   GH  + ++  +  E+   W EL  A 
Sbjct: 617  KSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676

Query: 1581 EARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEEL 1640
            + +   L +A    Q+  +  +L+ W+E+    V+S DYG+  A     + KH  L+  +
Sbjct: 677  KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736

Query: 1641 AIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEGTLRLH 1698
            A     ++ L   A        P+ +  R  QE L  +  AL+E  ATR ++L   L L 
Sbjct: 737  AARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796

Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
               R+ ED + W+   + +A     LG+D   +  L  +       +     R+      
Sbjct: 797  LICRDTEDEEAWIQETEPSAT-STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855

Query: 1759 AESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQV 1818
               ++E GH A   V  R + L      L      R + L       +   DL E  T +
Sbjct: 856  GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915

Query: 1819 QEKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
            +EK   + N N   D     A L+ H+    +L      ++ L              QA+
Sbjct: 916  REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN------------QAN 963

Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESS 1937
            A QQ+Q A  +  A  QR M     Q    R +   +    D  +  + + +D    E++
Sbjct: 964  ACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK---GDVLTLLSSINKDWWKVEAA 1020

Query: 1938 QEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT---KEVQEELRALQD 1994
                        HQ +   +  R     +   L Q+     G  T   ++++ + R+L D
Sbjct: 1021 D-----------HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD 1069

Query: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
            + ++       ++ RL     E L   E G + E +  +    K    G  +++V +L +
Sbjct: 1070 RAEE-------RRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWELQK 1118

Query: 2055 KHEVFLKVLTAQDKK--------EAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            K + F K L   + +        +  L E L T    ++R  L     R   ++ LA+ +
Sbjct: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELN---SRWGSLQRLADEQ 1175

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAH 2166
               L ++  +  F + A   ++ I+   Q L    P  DL        +H+ FE ++   
Sbjct: 1176 RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPL 1235

Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQ-GLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
             + +T + +  E  L++SHP A E  QR +  L + WEDL+     R + L + + F  F
Sbjct: 1236 GDKVTILGETAER-LSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLF 1294

Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
            L +    + WI      ++  +L +DL     L  R +E R +   +       +++ D 
Sbjct: 1295 LSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA---PTFQALEDF 1351

Query: 2286 SLQL----KNRDPE---EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL 2338
            S +L     +  PE   +++ +   R  L   W        + ++ L+  LE+ +     
Sbjct: 1352 SAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE-------KRKKILDQCLELQMFQGNC 1404

Query: 2339 DNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQR 2398
            D V   +  +E  +++ D    L+S++ L++K ++L++ +   + ++  LE     L   
Sbjct: 1405 DQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463

Query: 2399 SPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV-SAQRLRAQ 2457
               A   +  R Q V + W  L+++    R  L      ++    L+EL    ++ L   
Sbjct: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTA 1523

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL--TAGHPFSSDIRQV 2515
             D S    + ++ + +  +HQ    E+D  ++ +    + G  L+  +A       +++ 
Sbjct: 1524 CDESYKDATNIQRKYL--KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581

Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575
            L  L++    L     +   +L +A   Q F +S+   E WL   E  LA +     LA 
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641

Query: 2576 MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ 2635
               LL KH++LE ++  +   +  L   A  L   G       + +   +  R   +   
Sbjct: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701

Query: 2636 AGTRRHRLEELRQLQAFLQDSQEVAAWLREKNL-VALEEGLLDTAMLPAQLQKQQNFQAE 2694
            A     +L+E   L  F QD  +  +W+ EK + V+ ++   D   +   L+K +  + E
Sbjct: 1702 AAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGE 1761

Query: 2695 LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEA 2754
            L A     Q +    ++L        E IQ RL +    W +L++ ++ +  KL+++ E 
Sbjct: 1762 LVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEY 1821

Query: 2755 LRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL-------EAAVDKKARQ 2807
            L+  ++ EE E W+            G  L     LL     L       E  V     Q
Sbjct: 1822 LQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQ 1881

Query: 2808 AEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA 2867
             E +L +    V +     +++  +   L ++  SL + +   +  LE      +F   A
Sbjct: 1882 GEDILNK----VLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKA 1937

Query: 2868 DEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS--HEALTRVVLGTGYKLV 2925
            D   AW+ +K         G  L     L  +   L++ + S   E L  +      KL+
Sbjct: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT-DLKDKLI 1996

Query: 2926 QAGHFAAHEVAARVQQLEKAMAH-LRAEAARRRLLLQQ---AQEAQQFLTELLEAGSWLA 2981
             A H  +  +  R   L K     L A A  R+ LL++    Q+A+    E     S L 
Sbjct: 1997 SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALN 2056

Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQ-QTAALLESRKN----- 3035
                 ++ E++          L  +   ++D E F   + R Q     LLE  +      
Sbjct: 2057 NWCEKME-ENLSEPVHCVS--LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113

Query: 3036 -PESP----------KVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQ---------- 3074
             P SP          +    L  + E   + L++ EAR     E  Q  +          
Sbjct: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173

Query: 3075 LERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
            LE     LD  L  +  T ESQ     LE  K  +++  A ++++  +
Sbjct: 2174 LETRAYFLDGSLLKETGTLESQ-----LEANKRKQKEIQAMKRQLTKI 2216



 Score =  327 bits (838), Expect = 1e-88
 Identities = 408/2039 (20%), Positives = 788/2039 (38%), Gaps = 194/2039 (9%)

Query: 474  EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEV 533
            EE+   W  LL+    +  Q+         +QE       + + +  A S   G+     
Sbjct: 134  EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERT 193

Query: 534  VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALV 593
              L ++ +  + ++ A    V  + Q   E        + ++Q+K   +    + L  L 
Sbjct: 194  EVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLA 253

Query: 594  RARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV 653
              R+  L        F R+  E   W+KE    + +   G+DL    G    HK LE  +
Sbjct: 254  LQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNL 313

Query: 654  HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
                    +L  +   L+   P   P   E  E +   W+ ++     R  +LQ      
Sbjct: 314  AVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373

Query: 714  QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
            ++ +D  E + W+ E+ +++       D A  E LL RH + +  + ++    +  +E G
Sbjct: 374  RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433

Query: 774  RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
            +       L   N   S                                       + + 
Sbjct: 434  Q------DLVNANHEAS---------------------------------------DEVR 448

Query: 834  QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQR--VQPQA 891
            +  + L  ++ +L  L   R  + E+ +    F     ++  W+ +Q   L+   +    
Sbjct: 449  EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL 508

Query: 892  DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLE 951
             + E +  K+E+F  A    +     V  +A +L      +S  I+  ++ L  R   L 
Sbjct: 509  GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL- 567

Query: 952  ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL-------Q 1004
               REKA      ++    LQ+       L++ + + + L           L       Q
Sbjct: 568  ---REKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ 624

Query: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
            + +K+  V + ++  +Q    ++ E G+  S  +  ++  +  L +++ E   Q+  +  
Sbjct: 625  VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLH 684

Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
            E   +  F   ++ L  W E V+ Q+ S++    +A  Q  LR+H  L   +   Q+++ 
Sbjct: 685  EANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVD 744

Query: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
             L   +     +  PDS+++      L  + + LK     R++ L + L LQ   R+ + 
Sbjct: 745  ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTED 804

Query: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQH 1244
              A     +       LG+D+  +  LL +HR     +++  PR + +   G K+V+  H
Sbjct: 805  EEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGH 864

Query: 1245 PAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEK------ 1298
             AA  V  +++S+      L+ R+ +R+  L A++Q Q++  D+ E   W+ EK      
Sbjct: 865  FAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN 924

Query: 1299 -----------GLMAAHE-----------PSGARRNILQTLKRHEAAESELLATRRHVEA 1336
                        L+  HE              A RN     ++ +AA  E +A  + V A
Sbjct: 925  TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMA 984

Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKW---EALN----------------------- 1370
            L              + D+ T L  +   W   EA +                       
Sbjct: 985  LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQ 1044

Query: 1371 RKMTERGDELQQAGQQEQLLRQLQDAKEQ---------------------LEQLEGALQS 1409
            R+  E G+  Q+  Q E   R L D  E+                     LE ++   ++
Sbjct: 1045 RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ-EKKA 1103

Query: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLEL 1469
              TG +L     LQK+  + + +  T   ++  +  +A  +     +  E  +  + L  
Sbjct: 1104 ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNS 1163

Query: 1470 LQG---HLAIRGLQLQASVE----LHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQS 1522
              G    LA    QL  S       H+    +  ++    + +    P S    L   Q+
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGS---DLFSVQA 1220

Query: 1523 LHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA-QHIVEQCQELEGHWAELERACE 1581
            L R+H+  + ++    G    +L       +  HP A + +  Q  EL   W +L+   +
Sbjct: 1221 LQRRHEGFERDL-VPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279

Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
             R + L +A  F  +     +L+ W+     +VSS++   D      L+ +HQ  + ++ 
Sbjct: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339

Query: 1642 IYWSSMEELDQTAQTL------TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTL 1695
                + + L+  +  L        PE+ ++ + V+   R+ L    E    R + L+  L
Sbjct: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLE-RDDLEKAWE---KRKKILDQCL 1395

Query: 1696 RLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAAC 1755
             L  F    + ++ W+ +++ + +  +    D   A  L  K       +     ++   
Sbjct: 1396 ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEA--LMKKRDDLDKAITAQEGKITDL 1453

Query: 1756 RLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVL 1815
               AESL+   H A   +  R Q +   W  L          L D     + +RDL E+ 
Sbjct: 1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELE 1513

Query: 1816 TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQK--LCPG 1873
              + E   +  +   +D   ++ +   HQ    E+ G   Q+  ++     + +   C G
Sbjct: 1514 EWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573

Query: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933
             +  A++++ + + + W  L  R   +  +L  A    RF T++RD+  W +     L +
Sbjct: 1574 NE-EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAM 1632

Query: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993
            ++ +++ +S    L  HQ L  E+ ARE   +    L +  L +      ++ ++   + 
Sbjct: 1633 KDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVN 1692

Query: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053
             +   V +  A   E+L+       F ++    E  +  + + + +   G  ++ V+ L+
Sbjct: 1693 KRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLL 1752

Query: 2054 RKHEVFLKVLTAQD---KKEAALRERLK---TLRRPRVRDRLPILLQRRMRVKELAESRG 2107
            +KH+     L A +   +    + E+LK    + +  ++ RL   ++   ++KELA++RG
Sbjct: 1753 KKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARG 1812

Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKP----LLKHQAFEAEV 2163
              L  SL    F Q A + E    AW  +       GD  D L      L+KH+A E + 
Sbjct: 1813 LKLEESLEYLQFMQNAEEEE----AWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868

Query: 2164 QAHEEVMTSVAKKGEALL---AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
              HE  + +V  +GE +L    Q   +  E+S +++ L +    L +A+A    +LED  
Sbjct: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             F EF  + D+ EAWI +KE  +     G DL   L L  +      +++  +     + 
Sbjct: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL--DASLQSFQQERLP 1986

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRW-------ASFHGNLLRYQQQLEGALEIHV 2333
             I+DL  +L +    + K I +R + L  RW       A     LL  Q  L+ A ++ V
Sbjct: 1987 EITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046

Query: 2334 ----LSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
                 +  L+N  ++++E   L + + C   L  +++L + HE+    +   QA  + L
Sbjct: 2047 EFAHKASALNNWCEKMEEN--LSEPVHC-VSLNEIRQLQKDHEDFLASLARAQADFKCL 2102



 Score =  317 bits (811), Expect = 2e-85
 Identities = 433/2131 (20%), Positives = 824/2131 (38%), Gaps = 187/2131 (8%)

Query: 441  ILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV 500
            ++ +EGR   + + A+   +E +     +  +Q EV   W+RL      ++K +++   +
Sbjct: 207  LVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL 266

Query: 501  LSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQ 560
                ++V  A   ++E +    S   G+ L     L   H  LE  ++     V  L  +
Sbjct: 267  QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAK 326

Query: 561  TAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWL 620
              +L  S  +    +Q     L    + + AL  +R   L+ T     F  + +E   W+
Sbjct: 327  AEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWM 386

Query: 621  KECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPD 680
             E    +    L  D++     L +H+  + E+  +          G+DL         +
Sbjct: 387  NEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDE 446

Query: 681  PGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQ 740
              E+ E +   W  L      R  + +  L    ++ D+ +  SW+  + + LE    G 
Sbjct: 447  VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGN 506

Query: 741  DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
               +AE LL++H   E    AF A+    EE+         + TV+              
Sbjct: 507  SLGSAEALLQKHEDFE---EAFTAQ----EEK---------IITVD-------------- 536

Query: 801  PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
                           K A     D  +D   I   +D L    ++LR  A  RR  L+E+
Sbjct: 537  ---------------KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581

Query: 861  MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL-----KYENFLTALAVGKGLW 915
            + L        +L+ W+ K+    +++    D  ++  L     K + F   LAV K   
Sbjct: 582  LLLQKLYEDSDDLKNWINKK----KKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637

Query: 916  AEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECG 975
              +  + +++ +     S  +  +  E++  W +L    ++K  QL  + +   F     
Sbjct: 638  ENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697

Query: 976  PTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
              Q  L DV  Q+ +   G      ++      L +      + +V  L  +    EE G
Sbjct: 698  DLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIG 757

Query: 1032 YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLR 1091
            + +S+ ++ + E+L    + ++E +A R ++  +    Q   ++++    W +  +    
Sbjct: 758  HPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSAT 817

Query: 1092 SKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVL 1151
            S  +  D+ ++++LL  H+ +LE I   + R+Q++  +   M       +++V + ++ L
Sbjct: 818  STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSL 877

Query: 1152 GQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSL 1211
             Q  + L+    +RQ  L+  ++ Q++  ++          +  +   N G D   A +L
Sbjct: 878  NQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL 937

Query: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ-HPAAHTVREQ----LQSIQAQWTRLQG 1266
            L++H  F   L++ G   +ALR       Q Q  P      EQ    L   QA+  R   
Sbjct: 938  LKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVT 997

Query: 1267 RSEQRRRQLLASLQLQEWKQDVAE---------LMQWMEEKGLMAAHEPSGARRNILQTL 1317
              +     LL+S+    WK + A+         + +   ++  M          NI Q  
Sbjct: 998  MKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057

Query: 1318 KRHEAAESELL--ATRRHVEALQQVGRELLSRRPCG------------------------ 1351
            ++ E     LL  A  R    LQ+    LL+                             
Sbjct: 1058 EQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQ 1117

Query: 1352 ------QEDIQT---RLQGLRSKWEAL--NRKMTERGDELQQ------------AGQQEQ 1388
                  Q+D+ T   RL+ +    + L     +T  G +++Q            A +Q Q
Sbjct: 1118 KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQ 1177

Query: 1389 LL----------RQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
            LL          R+  D KEQ+E+   AL +++ G DL S Q LQ+RH+  E +   L  
Sbjct: 1178 LLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237

Query: 1439 KMAALASMAHGMAAS-PAILEETQKHLRRL----ELLQGHLAIRGLQLQASVELHQFCHL 1493
            K+  L   A  ++ S P   E+ Q+    L    E LQG    R   L  + + + F   
Sbjct: 1238 KVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297

Query: 1494 SNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAA 1553
            +    +W++      S     E L G + L  +H+E + +++A     Q +      L  
Sbjct: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357

Query: 1554 SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPL 1613
            SGH  +  I ++ Q ++    +LE+A E R + L Q +  Q +  +  ++E W+  +   
Sbjct: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENS 1417

Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ--E 1671
            + S D    ++    L+ K   L + +      + +L+  A++L   E   ++ +    +
Sbjct: 1418 LRSDDKSSLDSLE-ALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQ 1476

Query: 1672 RLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHA 1731
            R+ ++ +AL+        +L     L +F R+ E+L+ W++     A       E  + A
Sbjct: 1477 RVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTA-----CDESYKDA 1531

Query: 1732 LHLCTKFAK---FQHQVEMGSQRVAACRLLAESLLERGHSAG--PMVRQRQQDLQTAWSE 1786
             ++  K+ K   F H+V+  S++V     L  SL+E     G    ++++ + L+  W  
Sbjct: 1532 TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDH 1591

Query: 1787 LWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP-NNVARDLCGLEAQLRSHQG 1845
            L E T  +G  L +     R +  + +    + E  T L   + ARDL      L+ HQ 
Sbjct: 1592 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1651

Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGP-QAHAVQQRQQAVTQAWAVLQRRMEQRRAQL 1904
            LERE++  E  L++L   A  +  L  G      + +++  V + +  +Q        +L
Sbjct: 1652 LEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709

Query: 1905 ERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLW 1964
            + A  L +F   + D  SW       +  ++  ++       L  H+ L  EL A E   
Sbjct: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769

Query: 1965 QQATQLGQQALLAAGTPTKEVQ----------EELRALQDQRDQVYQTWARKQERLQAEQ 2014
            Q    + ++    A    +E+Q          E+L+ L   R    +      + +Q  +
Sbjct: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829

Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQ--DKKEAA 2072
            +E+ ++ E   L       +    T +L    E +E     HE  ++ + AQ  D     
Sbjct: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889

Query: 2073 LRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
            L+E     +   +  ++  L ++   + +   +    L        F   A   E WI  
Sbjct: 1890 LQEE---SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIAD 1946

Query: 2133 WAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEV 2191
                LK      DL D L  L K    +A +Q+  +E +  +    + L++  H ++  +
Sbjct: 1947 KETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAI 2006

Query: 2192 SQRLQGLRKHWEDLRQAMALRGQELEDRR--------NFLEFLQRVDLAEAWIQEKEVKM 2243
             +R   L K WE L +A A+  Q+L +++         F+EF  +      W ++ E  +
Sbjct: 2007 EERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL 2066

Query: 2244 NVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR 2303
            +       L    QL++   +F  + A      A  + + +L  Q+K             
Sbjct: 2067 SEPVHCVSLNEIRQLQKDHEDFLASLAR---AQADFKCLLELDQQIKALGVPSSPYTWLT 2123

Query: 2304 RSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL-----DNVTKRIQ-EKEALIQALDC 2357
               L   W      +   +Q+L+      V + E+      N +  +Q   E     LD 
Sbjct: 2124 VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD- 2182

Query: 2358 GKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESW 2417
            G  L+    L  + E  +R+   IQA    L + V             +++    +A+ W
Sbjct: 2183 GSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQW 2242

Query: 2418 WQLRSRAQKRREALDALHQAQKLQAMLQELL 2448
             QL     + +  L+   QA+ ++ + +E L
Sbjct: 2243 DQLYQLGLRMQHNLEQQIQAKDIKGVSEETL 2273



 Score =  290 bits (741), Expect = 2e-77
 Identities = 465/2346 (19%), Positives = 900/2346 (38%), Gaps = 241/2346 (10%)

Query: 469  VARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQ 528
            V    EE+  R Q +L   Q  +++VA+    L     ++      ++L         G+
Sbjct: 17   VLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDL---------GK 67

Query: 529  QLAEVVELL---------------QRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSV- 572
             + E V +L               Q+H  LEA+V      +S L ++T E   ++G S  
Sbjct: 68   WIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL-EKTREERFTMGHSAH 126

Query: 573  EVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL 632
            E  +A    L  L   L+ L   +   L + L+  ++++ C +   W+ +      +  L
Sbjct: 127  EETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVEL 186

Query: 633  GRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGW 692
            G D  +     +K +  + E+   +   V++ +   + +    P  P    +   V   W
Sbjct: 187  GEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAW 246

Query: 693  QLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRH 752
            + L+   + R   L  A  + ++  D  EA  W++E+   L     G+D  A+E L   H
Sbjct: 247  ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSH 306

Query: 753  VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
              LER L   + +++ L        A+A   T++                     HP   
Sbjct: 307  KGLERNLAVMSDKVKEL-------CAKAEKLTLS---------------------HPS-- 336

Query: 813  DAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGE 872
                           D   I + ++ L   +E +RALA  R  +L+       F S   E
Sbjct: 337  ---------------DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381

Query: 873  LQLWLEKQTVLLQRVQPQADTL--EVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYP 930
            L  W+ ++T  +   +   D    EV+  +++     +      +     + + L     
Sbjct: 382  LSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH 441

Query: 931  GNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ--VQLRDVLLQL 988
              S +++ + E L   W  L  L  E+  Q    ++   F ++       +  ++  L+ 
Sbjct: 442  EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLEN 501

Query: 989  EAL--QPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQ 1046
            E L    GS+E      +  ++     E ++  +     K+    + +S+ ++   + L 
Sbjct: 502  EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL 561

Query: 1047 GLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLL 1106
                 ++E+ A R R   E+   Q   ++S  L  W    + +L   E   D+ + +  +
Sbjct: 562  ARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRV 620

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
            ++ Q   +E+ + + +L+ +    Q M       S  V   L  +    +EL    +Q+ 
Sbjct: 621  QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680

Query: 1167 QWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLG 1226
              L E  +  +F    +       + +  +  ++ G+ + E  + L++H      ++   
Sbjct: 681  TQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ 740

Query: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
             + + L        +  HP +  +R + +S+  ++  L+     R+++LL  L LQ   +
Sbjct: 741  DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICR 800

Query: 1287 DVAELMQWMEE-----------KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
            D  +   W++E           K L+A+ +     R IL+ +  HE            ++
Sbjct: 801  DTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEP----------RIQ 850

Query: 1336 ALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQD 1395
             + + G +++       ED+ +R++ L    E+L  +   R ++L+   Q +Q L  L +
Sbjct: 851  EITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHE 910

Query: 1396 AKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA 1455
            A+  + + E  + ++  G D  ++  L K+H+    +  +    M AL + A+       
Sbjct: 911  AETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANAC----- 965

Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
                 Q+    +E + G         Q  + L+ F   S  E++     M  G   +   
Sbjct: 966  ----QQQQAAPVEGVAGE--------QRVMALYDFQARSPREVT-----MKKGDVLTLLS 1008

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP--------QAQHIVEQCQ 1567
             +N            +VE   HQG V  V    R LA    P        +  +I ++ +
Sbjct: 1009 SIN--------KDWWKVEAADHQGIVPAVYV--RRLAHDEFPMLPQRRREEPGNITQRQE 1058

Query: 1568 ELEGHWAE-LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAAT 1626
            ++E  +   L+RA E R + LQ+   F   + +  ++  W++EK+    + + G +    
Sbjct: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAY-EAGDMLEWIQEKK----AENTGVELDDV 1113

Query: 1627 LRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLREQLRALQELA 1684
              L  K    Q++L      + ++++ A  L   G   PE  ++ QE L  +  +LQ LA
Sbjct: 1114 WELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE-LNSRWGSLQRLA 1172

Query: 1685 ATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQ 1744
              + + L     +  F REA+D +  +  + QA    +  G D      L  +   F+  
Sbjct: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFERD 1231

Query: 1745 VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE-- 1802
            +     +V      AE L E    A   +++++ +L  AW +L   T+ R  +L + +  
Sbjct: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291

Query: 1803 -TTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
               L   RDL   ++ +    +S    +A DL G+E  L  HQ    ++       Q L 
Sbjct: 1292 YLFLSKARDLQNWISSIGGMVSS--QELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349

Query: 1862 ETAGRVQKLCPGPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
            + +  +  +  G  A   ++++ QAV      L++  E+R+  L++   L  F+      
Sbjct: 1350 DFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQV 1407

Query: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
             SW       L+ ++ S   S   L +     L   + A+E          +  +     
Sbjct: 1408 ESWMVARENSLRSDDKSSLDSLEAL-MKKRDDLDKAITAQEGKITDLEHFAESLIADEHY 1466

Query: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
              +E+   L+ + D+   +      ++ +L      + F R+   LEE ++     +  +
Sbjct: 1467 AKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS----EMLPT 1522

Query: 2041 ALGSSVEEVEQLIR---KHEVF--------------------LKVLTAQDKKEAALRERL 2077
            A   S ++   + R   KH+ F                    L   +A D  E A++E+L
Sbjct: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
            + L     ++    LL+R          +G  L+ +     F  +    E W+      L
Sbjct: 1583 EQL-----KEHWDHLLER-------TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLL 1630

Query: 2138 KEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG 2197
                   DL      L KHQ  E E+ A E+ +  +    E LL+       ++ ++   
Sbjct: 1631 AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDN 1690

Query: 2198 LRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
            + K + ++++  A   ++L++     +F Q +D  E+WI+EK ++++  D G+DL+    
Sbjct: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750

Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
            L ++ +   G        +  I+++ D++ +LK++     + I  R +Q    W      
Sbjct: 1751 LLKKHKRLEGELVAH---EPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKEL 1807

Query: 2318 LLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELERE 2377
                  +LE +LE     +  +     I EK AL    DCG  L + Q LL KHE LE +
Sbjct: 1808 AKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND 1867

Query: 2378 --VHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
              VH         E  V  +C +  +  + +   + +  E   ++ +  +K      A+ 
Sbjct: 1868 FAVH---------ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAI- 1917

Query: 2436 QAQKLQA----MLQELLVSAQRLRA-------QMDTSPAPRSPVEARRMLEEHQECKAEL 2484
             A KLQ       QE    A  + A        + T+       +   +L +     A L
Sbjct: 1918 AAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASL 1977

Query: 2485 DSW-TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH-------QLQ 2536
             S+  + +        +L++A H  S  I +  A L +    L  A   H       QL 
Sbjct: 1978 QSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037

Query: 2537 LQQALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAG 2595
            LQ+A +L + F      +  W    E++L+       L  +  L   H+     L     
Sbjct: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097

Query: 2596 KISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRL--EELRQL---- 2649
                L    + +   G P +       + +    + L      R   L  EE RQ+    
Sbjct: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157

Query: 2650 --QAFLQDSQEVAAWLREKNLVALEEGLL-DTAMLPAQLQKQQNFQAELDASMHQQQELQ 2706
              Q F Q++     W+ E     L+  LL +T  L +QL+  +  Q E+ A   Q  ++ 
Sbjct: 2158 MCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIV 2217

Query: 2707 REGQRL 2712
              G  L
Sbjct: 2218 DLGDNL 2223



 Score =  241 bits (614), Expect = 1e-62
 Identities = 215/995 (21%), Positives = 421/995 (42%), Gaps = 22/995 (2%)

Query: 2492 SLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVE 2551
            ++  S+G ++L          ++VL   +    S +    E   +L+ +  LQ+F    +
Sbjct: 8    TVVESSGPKVLETAEEIQERRQEVLTRYQ----SFKERVAERGQKLEDSYHLQVFKRDAD 63

Query: 2552 KMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGG 2611
             + +W+  K + L  +   DP   ++    KH+ LE +++ ++  +S LE T       G
Sbjct: 64   DLGKWIMEKVNILTDKSYEDP-TNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMG 122

Query: 2612 HPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVAL 2671
            H   +      + +    + L      +  +L    + Q ++Q+  ++  W+ +K  +A 
Sbjct: 123  HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182

Query: 2672 EEGLLDTAMLPAQLQKQ-QNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEEL 2730
               L +       L K+ ++FQ EL A   +  E+ +      +  HP    IQ +  E+
Sbjct: 183  SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242

Query: 2731 GALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGEL 2790
             A W  L+  + ++   L  A    R +R + E   W++  E  L +   G+ L     L
Sbjct: 243  NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302

Query: 2791 LGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQER 2850
              + + LE  +   + + + L  +A+         A  ++E    L+  ++ +R     R
Sbjct: 303  FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362

Query: 2851 RTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSH 2910
               L+A     +F  D DE   W+ EK     A +    ++    L ++HQ  + E+ S+
Sbjct: 363  YEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY 422

Query: 2911 EALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFL 2970
            +   +    TG  LV A H A+ EV  +++ L+     L      R    +Q  +   F 
Sbjct: 423  DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482

Query: 2971 TELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALL 3030
             +  +  SW++ +   L++ED+G+S  + +ALL++ E  +    A   +I  + +TA  L
Sbjct: 483  RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKL 542

Query: 3031 ESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKA 3090
                + +S  + A    +      L  +A  R   L+E L L +L  ++  L  W+  K 
Sbjct: 543  IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK 602

Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
              A+ +DY +D++ +K   +K   F KE+ ++ + ++  ++K    +  G      ++  
Sbjct: 603  KLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTGQEMIEGGHYASDNVTT 660

Query: 3151 QRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLS 3210
            + S + + WE L +A K +   L  A++   F+  A +LQ  +++    +  ED G  L+
Sbjct: 661  RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA 720

Query: 3211 SVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL-HPAAPGGLAKVQE---AWATLQA 3266
             V+   ++H  LE  + A + +V  L   A    ++ HP +    A+ +     +  L+ 
Sbjct: 721  EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780

Query: 3267 KAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQ 3326
                R + L             ++  AW QE +  A+S  L +D+  +++LL +H  + +
Sbjct: 781  PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840

Query: 3327 EIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386
             I     + Q++ + G ++V+  HF + +V   ++ L   ++ L    A R      +  
Sbjct: 841  NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900

Query: 3387 LQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
             Q+    L +AE W+   E ++   +YG        LL +H+            F    K
Sbjct: 901  FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE----AFLLDLNSFGDSMK 956

Query: 3447 TEMEQELLLQPQELKP--GRAGS----SLTSFQWR 3475
                Q    Q Q+  P  G AG     +L  FQ R
Sbjct: 957  ALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991



 Score =  239 bits (611), Expect = 3e-62
 Identities = 363/1900 (19%), Positives = 726/1900 (38%), Gaps = 156/1900 (8%)

Query: 421  PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480
            P  +A  E  + R    +  I   + RFQ+  E    L    + +  +V  + E +   W
Sbjct: 399  PTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNW 458

Query: 481  QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540
              LL+    + +Q           ++ E     +   +    +   G  L     LLQ+H
Sbjct: 459  TALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKH 518

Query: 541  DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            +  E   +A    +  + +   +L        E ++A    L   + +L      RR LL
Sbjct: 519  EDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLL 578

Query: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
            +++L   +   + ++ + W+ +  +++ +    +D+  +   +QK +  E E+  ++   
Sbjct: 579  KESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637

Query: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
             ++ + G+++         +   R   V   W+ L      +G +L  A   LQ+  +A 
Sbjct: 638  ENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697

Query: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
            +   WL +    +     G+  A  +  LR+H  LE                  A +AR 
Sbjct: 698  DLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE-----------------SAVAARQ 740

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                + + L+   E + +P                            D   I   Q+ L 
Sbjct: 741  DQVDILTDLAAYFEEIGHP----------------------------DSKDIRARQESLV 772

Query: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL- 899
              +E+L+     R+ +L + + L   C    + + W+++            D +   +L 
Sbjct: 773  CRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLL 832

Query: 900  -KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958
             ++   L  +A  +    E++    ++ +     +  +  + + L+Q    L A    + 
Sbjct: 833  NRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ 892

Query: 959  VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018
              L  +V+   +L +    +  +R+    ++    G+ E+   AL         L++   
Sbjct: 893  NDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL---------LKKHEA 943

Query: 1019 FLQSVVVKVEEPGYAES-QPLQGQVETLQGLLKQVQEQVA--QRARRQAETQAR--QSFL 1073
            FL      ++   + +S + L+ Q    Q       E VA  QR     + QAR  +   
Sbjct: 944  FL------LDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVT 997

Query: 1074 QESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM 1133
             +   +L    S+       E +           +HQ ++  +++   RL   +    P 
Sbjct: 998  MKKGDVLTLLSSINKDWWKVEAA-----------DHQGIVPAVYV--RRLAHDEFPMLPQ 1044

Query: 1134 AALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ 1193
               + P +  +      +  Q + L    E+R++ L     LQ++   +  + A   +  
Sbjct: 1045 RRREEPGN--ITQRQEQIENQYRSLLDRAEERRRRL-----LQRYNEFLLAYEA--GDML 1095

Query: 1194 AWLH---LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQS--QHPAAH 1248
             W+     +N G ++ +   L ++  EF + L+T  PR   +    + L+      P   
Sbjct: 1096 EWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGA 1155

Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEK-GLMAAHEPS 1307
             +R++L S   +W  LQ  ++++R+ L ++  ++ + ++  +  + +E+K   ++A +P 
Sbjct: 1156 QIRQELNS---RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPG 1212

Query: 1308 GARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
                ++    +RHE  E +L+     V  L +    L    P   ED+Q +   L   WE
Sbjct: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272

Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQ 1427
             L  +  +R + L +A +    L + +D +  +  + G + S E  +DL   + L +RHQ
Sbjct: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332

Query: 1428 QLESESRTLAAKMAALASMA-----HGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQ 1482
            +  ++    A    AL   +      G  ASP I ++ Q      + L+     R   L 
Sbjct: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILD 1392

Query: 1483 ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQ 1542
              +EL  F    +   SW+     +   +     L+  ++L +K  +L   + A +G++ 
Sbjct: 1393 QCLELQMFQGNCDQVESWMVAR-ENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKIT 1451

Query: 1543 RVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSE 1602
             +     SL A  H   + I  + Q +   W  L+         L      +Q++ D+ E
Sbjct: 1452 DLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEE 1511

Query: 1603 LEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEV 1662
            LE W+ E  P      Y +D     R   KHQ    E+      +  +     +L     
Sbjct: 1512 LEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSA 1570

Query: 1663 PEQQRVVQERLREQLRALQE-----LAATRD--RELEGTLRLHEFLREAEDLQGWLASQK 1715
             +     +E ++EQL  L+E     L  T D  ++L    R   F     D + WL S+ 
Sbjct: 1571 CDGN---EEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWL-SEA 1626

Query: 1716 QAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQ 1775
            +     +    D   A +L  K    + ++      +     LAE LL  G      + +
Sbjct: 1627 ETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686

Query: 1776 RQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-NVARDLC 1834
            ++ ++   +  + EL  A    L++     +  +DL +  + ++EK   + + +  RDL 
Sbjct: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQ 1746

Query: 1835 GLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQ 1894
            G++  L+ H+ LE ELV  E  +Q +L+ A +++      Q   +Q R     + W  L+
Sbjct: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ-EEIQLRLAQFVEHWEKLK 1805

Query: 1895 RRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLR 1954
               + R  +LE +    +F     +  +W           +     ++    L  H+ L 
Sbjct: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865

Query: 1955 AELEAREKLWQQATQLGQQAL---LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQ 2011
             +    E   Q     G+  L   L   +  KE+  ++ AL ++   + +  A  + +L+
Sbjct: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE 1925

Query: 2012 AEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVF------------ 2059
             +   Q F  +   +E  +A +E SLKT+  G+ + +   L+ K +              
Sbjct: 1926 DDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985

Query: 2060 -------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHA 2112
                    K+++AQ  +  A+ ER   L    ++    +L    +  ++L E +     A
Sbjct: 1986 PEITDLKDKLISAQHNQSKAIEERYAAL----LKRWEQLLEASAVHRQKLLEKQLPLQKA 2041

Query: 2113 SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEV---QAHEEV 2169
              L   F   A+   +W +   + L EPV    L +  +    H+ F A +   QA  + 
Sbjct: 2042 EDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKC 2101

Query: 2170 MTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDL--RQAMALRGQELEDRRNF---LE 2224
            +  + ++ +AL   S P      + L+   KH  D+   +   L+ +E    +NF    E
Sbjct: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161

Query: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQD---LEHCLQLRRR 2261
            F Q       WI E       G L ++   LE  L+  +R
Sbjct: 2162 FEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKR 2201



 Score =  210 bits (534), Expect = 2e-53
 Identities = 252/1302 (19%), Positives = 522/1302 (40%), Gaps = 95/1302 (7%)

Query: 2178 EALLAQSHPR----AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
            E ++  S P+    A E+ +R Q +   ++  ++ +A RGQ+LED  +   F +  D   
Sbjct: 7    ETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLG 66

Query: 2234 AWIQEK---------EVKMNVG---DLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRS 2281
             WI EK         E   N+       Q LE  +Q + RL              + +  
Sbjct: 67   KWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLM-------------SELEK 113

Query: 2282 ISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNV 2341
              +    + +   EE K   +   +L + W       L    QL  AL+     +E  ++
Sbjct: 114  TREERFTMGHSAHEETKAHIE---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADI 170

Query: 2342 TKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPE 2401
             + I +KEA+  +++ G+D E  + L +K E+ + E+   + +V  + +      + +  
Sbjct: 171  LEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP 230

Query: 2402 AAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTS 2461
                ++ +Q EV  +W +LR  A +R++AL      Q+ +  + E +   +     + + 
Sbjct: 231  DLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSE 290

Query: 2462 PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ 2521
               +  V +  +   H+  +  L   +D +    +  ++ LT  HP  SD  Q+    E 
Sbjct: 291  DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEK-LTLSHP--SDAPQIQEMKED 347

Query: 2522 ELSSLE---GAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
             +SS E           +LQ       F S  +++  W+  K  ++ ++ L   +A  E 
Sbjct: 348  LVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEV 407

Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGT 2638
            LL +H+  + +++    +  + + T + L    H  +     + + +     AL      
Sbjct: 408  LLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467

Query: 2639 RRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDT-AMLPAQLQKQQNFQAELDA 2697
            R  + E+      F +DS++V +W+  +      E L ++     A LQK ++F+    A
Sbjct: 468  RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527

Query: 2698 SMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRL 2757
               +   + +   +L+   H  SE I+   + L A    L++ +  +   L+++    +L
Sbjct: 528  QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587

Query: 2758 RRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQA 2817
                ++L+NW+   + +L      + +  +   +  Q+  E  +     Q E +    Q 
Sbjct: 588  YEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE 646

Query: 2818 FVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK 2877
             +  GH  + +V  +   +   ++ L E  +++ T L   +  L+F  +A++   W+++ 
Sbjct: 647  MIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV 706

Query: 2878 LPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAA 2937
                 ++DYG+ L+ V++   +H  LES +++ +    ++        + GH  + ++ A
Sbjct: 707  EWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRA 766

Query: 2938 RVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAE 2997
            R + L      L+   A R+  L      Q    +  +  +W+ E      S  +G    
Sbjct: 767  RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLI 826

Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLR 3057
            A++ LL R      ++ +  PRI+ + +    +    +  +  V ++++++ +    L  
Sbjct: 827  ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRA 886

Query: 3058 RAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRK 3117
            RA  R + L+  +Q  Q   +    + W+  K    ++ +YG D E    L +K +AF  
Sbjct: 887  RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946

Query: 3118 EVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAH 3177
            ++ S G + + ALR  A   +                         Q   A  E +A   
Sbjct: 947  DLNSFGDS-MKALRNQANACQ-------------------------QQQAAPVEGVAGEQ 980

Query: 3178 EVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE----- 3232
             V     A  + Q R   +  + KG+        V TL     +   ++EA + +     
Sbjct: 981  RV----MALYDFQARSPREVTMKKGD--------VLTLLSSINKDWWKVEAADHQGIVPA 1028

Query: 3233 --VARL-QTEACRLGQLHPAAPGGLAKVQE----AWATLQAKAQERGQWLAQAAQGHAFL 3285
              V RL   E   L Q     PG + + QE     + +L  +A+ER + L Q        
Sbjct: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
                ++L W QE++    +E    ++    +L  + +E  +++     + +D+ +    L
Sbjct: 1089 YEAGDMLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDL 1144

Query: 3346 VDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWE 3405
            +     ++ E  +  QEL  R   L+     + Q    +  ++   +  +  +  +    
Sbjct: 1145 LFEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKC 1203

Query: 3406 GLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
              L   D G  +  V+ L  RH+  E+ L    +K   + +T
Sbjct: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245



 Score =  150 bits (378), Expect = 3e-35
 Identities = 236/1215 (19%), Positives = 467/1215 (38%), Gaps = 133/1215 (10%)

Query: 271  LLQTQYEQLVA----DLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQ 326
            LLQ   E L+A    D+L WI EK+ +    +  D     ++         T E  PRL+
Sbjct: 1078 LLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNE--PRLR 1135

Query: 327  Q-RGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQ 385
                 A+ LLF                 EGL   E +Q             Q L  R   
Sbjct: 1136 DINKVADDLLF-----------------EGLLTPEGAQI-----------RQELNSRWGS 1167

Query: 386  LQRLETLARRFQHKAALRESFLKDAEQVLDQ---------ARAPPASLATVEAAVQRLGM 436
            LQRL    R+    A   E F ++A+   +Q         A  P + L +V+A  +R   
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
             E  ++P   +   L E A+ L +    +  D+ R++ E+   W+ L    + +++ + +
Sbjct: 1228 FERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE 1287

Query: 497  MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556
             Q     L +     + +  +     S    + L  +  LL+RH    A + A       
Sbjct: 1288 AQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQA 1347

Query: 557  LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
            L   +AEL  S   +   ++ K + +   +  L      R+ +L+Q L+   F  NC++ 
Sbjct: 1348 LEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQV 1407

Query: 617  EAWL--KECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARR 674
            E+W+  +E   R  + +    L  +   ++K   L+  +   +    DL      L A  
Sbjct: 1408 ESWMVARENSLRSDDKS---SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464

Query: 675  PPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLE 734
               + +   R + V   W+ L+ +++    +L     + Q++ D  E   W+    S + 
Sbjct: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWI----SEML 1520

Query: 735  RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGE 794
              +C +    A  + R++++ +     FA E+      GR+      +   NS +     
Sbjct: 1521 PTACDESYKDATNIQRKYLKHQ----TFAHEV-----DGRSEQVHGVINLGNSLI----- 1566

Query: 795  SLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRR 854
                     E S   G  +A K  L                 + L + ++ L      + 
Sbjct: 1567 ---------ECSACDGNEEAMKEQL-----------------EQLKEHWDHLLERTNDKG 1600

Query: 855  ARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGK 912
             +L EA     F +S  + + WL +   LL       D      L  K++     +   +
Sbjct: 1601 KKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARE 1660

Query: 913  GLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQ 972
                ++++ AE L      N  QI ++++ +++R+  ++ L      +L  +  +  F Q
Sbjct: 1661 DALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQ 1720

Query: 973  ECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKK----TLVLERRVHFLQSVVVKVE 1028
            +    +  + + L+++ +   G        L    K+     +  E  +  +  +  K++
Sbjct: 1721 DLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLK 1780

Query: 1029 EPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQA 1088
            +      + +Q ++       ++++E    R  +  E+     F+Q +++   W     A
Sbjct: 1781 DKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNA 1840

Query: 1089 QLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM---AALDCPDSQEVP 1145
                 +    +A+ Q LL +H+ L  +  + + R+Q + AQ + +      +   ++E+ 
Sbjct: 1841 LAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEIS 1900

Query: 1146 NTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDV 1205
            + +  L ++   L       +  L++    Q+F  + D   A  A+ +  L  +  G D+
Sbjct: 1901 SKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADL 1960

Query: 1206 REALSLL-QQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
             + L+LL +Q      L S    R   +    +KL+ +QH  +  + E+  ++  +W +L
Sbjct: 1961 GDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQL 2020

Query: 1265 QGRSEQRRRQLL-ASLQLQ-------EWKQDVAELMQW---MEEKGLMAAHEPSGARRNI 1313
               S   R++LL   L LQ       E+    + L  W   MEE      H  S     I
Sbjct: 2021 LEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS--LNEI 2078

Query: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
             Q  K HE   + L   +   + L ++ +++ +            ++ L   W+ L+  +
Sbjct: 2079 RQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDII 2138

Query: 1374 TERGDELQ-QAGQQEQLLRQLQDAKEQLEQ------------LEGALQSSETG---QDLR 1417
             ER  ELQ +  +Q +     Q+ ++                L+G+L   ETG     L 
Sbjct: 2139 EEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL-LKETGTLESQLE 2197

Query: 1418 SSQRLQKRHQQLESE 1432
            +++R QK  Q ++ +
Sbjct: 2198 ANKRKQKEIQAMKRQ 2212



 Score =  103 bits (258), Expect = 2e-21
 Identities = 106/452 (23%), Positives = 197/452 (43%), Gaps = 53/452 (11%)

Query: 249 LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
           L +    +RRL      L+E+ LLQ  YE    DL  WI +K+   +  D+ D       
Sbjct: 567 LREKAATRRRL------LKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD------- 612

Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEG---------LGLA 359
                     Q    R+Q++   E  L   +T L+   +      EG           L+
Sbjct: 613 ---------IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLS 663

Query: 360 ELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAE-QVLDQAR 418
           E++  W  L  A   +   L +   QLQ        F++ A   + +L+D E QV  +  
Sbjct: 664 EVASLWEELLEATKQKGTQLHEANQQLQ--------FENNAEDLQRWLEDVEWQVTSEDY 715

Query: 419 APPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTV 478
                LA V+  +++ G+LE+ +  ++ +   L ++A    +  +    D+  RQE +  
Sbjct: 716 GK--GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773

Query: 479 RWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
           R++ L + L  ++K++ D+  +  + ++ E     ++E +  A ST  G+ L    +LL 
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833

Query: 539 RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
           RH ++   +++H   +  + ++  ++      + E + ++ ++L Q  +SL A    R+ 
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893

Query: 599 LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
            LE  +Q  ++L +  E E W++E    V N   G D  + AGAL K         +H+A
Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGAD-EEAAGALLK---------KHEA 943

Query: 659 VCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
             +DL   G  + A R        ++A  V+G
Sbjct: 944 FLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975



 Score = 42.7 bits (99), Expect = 0.007
 Identities = 85/429 (19%), Positives = 171/429 (39%), Gaps = 40/429 (9%)

Query: 264  LQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLL----AAFTIFRTQ 319
            L+L+E+ L   Q+ Q   +   WI EK       D  D+L A + LL    A    F   
Sbjct: 1813 LKLEES-LEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVH 1871

Query: 320  EKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQAL 379
            E   R+Q   A    +       ++QN+            E+S     L     + ++A+
Sbjct: 1872 E--TRVQNVCAQGEDILNKVLQEESQNK------------EISSKIEALNEKTPSLAKAI 1917

Query: 380  QQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEA 439
                LQL+  +   + F  KA + E+++ D E  L +     A L      + +   L+A
Sbjct: 1918 AAWKLQLED-DYAFQEFNWKADVVEAWIADKETSL-KTNGNGADLGDFLTLLAKQDTLDA 1975

Query: 440  GILP-QEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQ 498
             +   Q+ R   + ++ D L   Q++    +  R   +  RW++LL+     R+++ + Q
Sbjct: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035

Query: 499  AVLSLLQEV--------EAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAH 550
              L   +++         A ++  E+++E          L E+ +L + H+   A ++  
Sbjct: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095

Query: 551  GAHVSHLAQQTAELDSSLGT--------SVEVLQAKARTLAQLQQSLVALVRARRALLEQ 602
             A    L +   ++  +LG         +VEVL+   + L+ + +     ++   A   +
Sbjct: 2096 QADFKCLLELDQQI-KALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVK 2154

Query: 603  TLQRA-EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661
              +   EF +N      W+ E      + +L ++   +   L+ +K  + E+   +    
Sbjct: 2155 NFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLT 2214

Query: 662  DLVRRGRDL 670
             +V  G +L
Sbjct: 2215 KIVDLGDNL 2223



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 81/354 (22%), Positives = 137/354 (38%), Gaps = 48/354 (13%)

Query: 286  WIAEKQMQLEAR-------DFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRL 338
            WIA+K+  L+         DF   L     L A+   F+ QE+ P +      + L+   
Sbjct: 1943 WIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQ-QERLPEITD--LKDKLISAQ 1999

Query: 339  QTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH 398
                +A   R          A L + W  L  A A   Q L ++ L LQ+ E L   F H
Sbjct: 2000 HNQSKAIEER---------YAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050

Query: 399  KAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADIL 458
            KA+   ++ +  E+ L +      SL  +    +      A +   +  F+ L E+   +
Sbjct: 2051 KASALNNWCEKMEENLSEP-VHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQI 2109

Query: 459  R----QEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQA----VLSLLQEVEA- 509
            +        ++W  V    E +   W+ L   ++ + +++   +A       + QE E  
Sbjct: 2110 KALGVPSSPYTWLTV----EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQN 2165

Query: 510  ASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDS--S 567
            AS  L+ + E       G        LL+    LE+Q+ A+      +     +L     
Sbjct: 2166 ASTFLQWILETRAYFLDG-------SLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218

Query: 568  LGTSVE---VLQAKART--LAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
            LG ++E   +L  K  T  LAQ    L  L    +  LEQ +Q A+ ++   EE
Sbjct: 2219 LGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ-AKDIKGVSEE 2271


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  358 bits (920), Expect = 4e-98
 Identities = 660/2892 (22%), Positives = 1152/2892 (39%), Gaps = 414/2892 (14%)

Query: 10   IRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPP 69
            I  L+    ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP 
Sbjct: 11   ISSLKDERDRVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR 68

Query: 70   PSRGRLRVHFLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHI 128
              +GR+R H L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I
Sbjct: 69   -EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI 127

Query: 129  SLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDL 188
             +  +    +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L
Sbjct: 128  QVSGQSEDMTA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLL 182

Query: 189  LDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSR 248
            +D   +     L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R
Sbjct: 183  IDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR 242

Query: 249  LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
            +   Q   R          E +L   +Y +LV  LL+W+       E R FP S   +  
Sbjct: 243  VPDVQDGVR--------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEI 294

Query: 309  LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAG 367
            L + F  F+  E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  
Sbjct: 295  LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGK 350

Query: 368  LEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATV 427
            L  A   R + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L   
Sbjct: 351  LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAA 406

Query: 428  EAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ- 481
                QR G +E  +   +   + L      L+  ++     + RR     +  V +R + 
Sbjct: 407  GKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY 466

Query: 482  --RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
              RL   +     QVA +  + S+ +  E     L  LQ+        Q   +  E    
Sbjct: 467  NLRLKAGVAAPATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD 525

Query: 540  HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRA 595
               +EAQ+ +H      + +  A+++ +     ++  A        L +L      L+ +
Sbjct: 526  LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS 585

Query: 596  RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
             +A L        F+    +E  WL E  +           + +    + + AL  E+  
Sbjct: 586  SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
             +    +L   G  L     P +P       A+Q  W  +        A L+      Q+
Sbjct: 646  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 705

Query: 716  FADAAEAASWLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGR 774
            F+D  EA   L++ + +L R  SC  D++A  T      RLE +L+    E  +L E   
Sbjct: 706  FSDVREAEGQLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKG 757

Query: 775  AASARASLFTVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD-- 824
              S  A        L P  P   +R   P      + +       GD  ++  PA+P   
Sbjct: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817

Query: 825  ------------PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSS 869
                        P      P    + Q+ +++     +AL  L      +  +L  + S 
Sbjct: 818  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877

Query: 870  CGELQLWLEKQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQ 927
              ++QL         + ++P  Q   L  ++L Y+ FL       G   E    AE   +
Sbjct: 878  RRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---R 934

Query: 928  RYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQ 987
             Y   S   Q+  + L Q  G  E  + ++ +                    +L+D+ LQ
Sbjct: 935  EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQ 973

Query: 988  LEALQPGSSEDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE----------------- 1028
            LEA +      T H L+L   K    E  +R+   Q    +VE                 
Sbjct: 974  LEACE----TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029

Query: 1029 ---EPGYAESQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARR 1062
               EP  A +  L+ ++E   G L+QV+                       E+V +    
Sbjct: 1030 ALPEPSPA-APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1088

Query: 1063 Q-AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDL 1112
            Q  E QA  + L E +      + ++AQ  +++ + D             +RL + H + 
Sbjct: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148

Query: 1113 LEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEG 1172
              E+  W+ER+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+ 
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDA 1204

Query: 1173 LELQKFGR-----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLL 1222
               Q+  +     +           QA L  ++  GE V E     +Q+    +++   L
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1264

Query: 1223 STLGPRAEALRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
             T   + E + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+ 
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321

Query: 1282 QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVG 1341
             E ++ +AE  Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++ 
Sbjct: 1322 MEEEERLAE-QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ 1376

Query: 1342 RELLSRRPCG------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG----------- 1384
             E++ R          +  IQ  LQ LR   EA  +    + +  +++            
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436

Query: 1385 -QQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAAL 1443
             Q E   RQ   A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A 
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAE 1492

Query: 1444 ASMAHGMAASPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWV 1501
              +A  + A      E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRS 1551

Query: 1502 AEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQH 1561
            AE        S+ E       L R  +E  V V   + + +R         A    +A+ 
Sbjct: 1552 AEAELQSKRASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAER 1600

Query: 1562 IVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGR 1621
              E+ +     W    +A EA    LQ     QQ  L  +E E   EE       R    
Sbjct: 1601 AREEAERELERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658

Query: 1622 DEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQ 1681
            ++A   R + + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718

Query: 1682 ELAAT---RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKF 1738
              AA    + +ELE      E  +   +++  LAS+ +A +   S  E  +  L    + 
Sbjct: 1719 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEA 1771

Query: 1739 AKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHAL 1798
             +F+   E+  +      L  E+  +R  +     RQR +    A   L E   A G A 
Sbjct: 1772 GRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEAT 1824

Query: 1799 R-DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQL 1857
            R  TE  + +     E      E+   L  + A     LE Q   H+         E +L
Sbjct: 1825 RLKTEAEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERL 1873

Query: 1858 QELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAV 1917
             +L + +    +   G     ++QR+Q   +  A+     +    + E    L R R+  
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA 1977
             D      R ++  ++E + Q            + L AE E R +  ++  Q    A   
Sbjct: 1934 ED----TLRSKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSL 2037
            A    K   EE+  L+ + ++      R +ER + E   QL L +    + + A  E   
Sbjct: 1978 AARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKA 2031

Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRM 2097
               A+    +E++Q +++ +  L  L  + +   A R   +     RV+           
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE--------- 2079

Query: 2098 RVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLL 2154
              +E A+SR     A  L  S  + A QA    QA A++L++       R    +   L 
Sbjct: 2080 --REAAQSRRQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136

Query: 2155 KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQ 2214
            + QA +AE++ H+       K  E  L Q      +V Q L  LR           L+ +
Sbjct: 2137 QKQAADAEMEKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLE 2174

Query: 2215 ELEDRRNFL-EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAG 2271
            E + ++N L E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--------- 2225

Query: 2272 DTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEI 2331
            +    A I    D + +    + E++K                        Q  E A  +
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAEKMK------------------------QVAEEAARL 2261

Query: 2332 HVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLERE 2391
             V ++E   + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQ 2313

Query: 2392 VGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSA 2451
                 + + E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A
Sbjct: 2314 K----ELAQEQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEA 2360

Query: 2452 QRLR---AQMDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTA 2504
            +RL+   A+M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   +
Sbjct: 2361 ERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419

Query: 2505 GHPFSSDIRQVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS-- 2548
             H  +  +R+ +A LE+E   L              +   QE  LQ  QAL+ Q FLS  
Sbjct: 2420 DHD-AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEK 2477

Query: 2549 -SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARG 2606
             S+ + ER++  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R 
Sbjct: 2478 DSLLQRERFI-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536

Query: 2607 LHQG--GHPEAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AA 2661
             H+   G    Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596

Query: 2662 WLREKNLVALEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQ 2714
             +     +      LD     A+       L+++ + Q   +A +   +ELQR  Q    
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ---- 2652

Query: 2715 GGHPASEAIQER 2726
             GH   + +  R
Sbjct: 2653 -GHTTVDELARR 2663



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 403  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 462

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 463  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 522

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 523  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 581

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 582  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 637

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 698  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 818  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 878  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 932

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 933  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 992

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 993  P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1033

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1090

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1150

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1206

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1556

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1617 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1725 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1778 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1830

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1890

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2068

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2127

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2182

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2237

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2293

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2294 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2342

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2343 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2446

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2447 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2496



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 362  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 418

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 419  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 478

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 479  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 522

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 523  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 577

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 578  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 630

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 631  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 690

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 691  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 740

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 741  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 772

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 773  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 818

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 819  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 875

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 876  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 930

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 931  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 990

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1107

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1162

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1282

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1340

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1401 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1512

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1563

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1564 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1610

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1611 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1848

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2081

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2138

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2188

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2189 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2210

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2211 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2262

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2263 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2300

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2301 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2350

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2351 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2390

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2391 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2429

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2430 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2470

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2580



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 501  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 560

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 561  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 617

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 618  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 677

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 678  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 737

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 738  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 793

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 794  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 853

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 854  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 913

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 914  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 973

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 974  LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1034 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1092

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1093 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1152

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1213 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1255

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1256 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1305

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1306 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1408

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1409 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1461 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1517

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1518 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1575 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1628

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1687

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1721

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1774

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1775 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1828

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1829 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1880

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1940

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2000

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2001 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2054

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2111

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2169

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2170 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2191

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2192 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2244

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2305 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2423 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2479

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2538 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2587

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2588 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2627

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2628 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2683

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2684 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2720



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 322  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 376

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 377  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 436

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 437  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 493

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 494  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 546

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 547  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 604

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 605  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 664

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 665  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 724

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 725  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 779

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 780  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 839

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 840  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 900  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 959

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 960  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1015

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1016 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1132

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1133 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1184

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1240

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1360

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1412

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1413 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1469 QAQEEAERL 1477



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 316  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 371

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 428

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 429  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 488

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 489  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 548

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 549  KIERARSDEGQL 560


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 42   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 98

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 99   KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 158

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 159  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 213

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 214  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 273

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 274  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 325

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 326  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 381

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 382  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 437

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 438  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 498  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 556

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 557  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 616

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 617  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 677  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 736

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 737  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 789  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 849  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 908

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 909  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 965

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 966  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1000

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1001 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1059

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1060 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1296 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1353 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1407

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1468 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1523

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1583 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1631

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1632 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1750 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1799

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1856 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1904

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1960

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1961 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 2009 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2062

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2108

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2109 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2168 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2205

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2256

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2257 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2292

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2293 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2340

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2341 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2391

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2449

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2508

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2509 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2682

Query: 2724 QER 2726
              R
Sbjct: 2683 ARR 2685



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 425  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 485  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 545  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 603

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 604  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 660  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 719

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 720  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 780  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 839

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 840  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 899

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 900  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 954

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1015 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1055

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1112

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1228

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1578

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1639 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1747 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1800 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1852

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2090

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2204

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2259

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2315

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2316 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2364

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2365 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2468

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2469 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 384  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 440

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 441  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 501  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 544

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 545  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 599

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 600  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 652

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 653  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 712

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 713  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 762

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 763  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 794

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 795  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 840

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 841  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 897

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 898  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 952

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 953  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1012

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1129

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1184

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1362

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1423 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1534

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1585

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1586 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1632

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1633 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2103

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2160

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2210

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2211 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2232

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2233 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2284

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2285 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2322

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2323 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2372

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2373 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2413 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2451

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2452 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2492

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2602



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 523  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 583  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 640  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 699

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 700  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 759

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 760  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 815

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 816  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 875

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 876  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 935

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 936  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 996  LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1056 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1235 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1277

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1278 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1328 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1430

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1431 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1483 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1539

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1540 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1597 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1650

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1709

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1743

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1796

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1797 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1851 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1902

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2023 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2076

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2191

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2192 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2213

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2214 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2266

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2327 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2445 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2501

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2560 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2610 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2649

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2650 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2705

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 344  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 398

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 399  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 459  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 515

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 516  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 568

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 626

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 627  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 686

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 687  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 746

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 747  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 801

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 802  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 862  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 922  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 982  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1037

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1038 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1154

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1155 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1206

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1262

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1434

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1435 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1491 QAQEEAERL 1499



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 278  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 338  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 393

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 450

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 451  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 510

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 511  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 570

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 571  KIERARSDEGQL 582


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 46   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 102

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 103  KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 162

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 163  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 217

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 218  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 277

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 278  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 329

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 330  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 385

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 386  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 441

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 442  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 501

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 502  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 560

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 561  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 620

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 621  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 680

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 681  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 740

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 741  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 792

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 793  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 852

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 853  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 912

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 913  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 969

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 970  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1004

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1005 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1063

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1064 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1123

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1299

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1300 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1357 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1411

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1472 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1527

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1586

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1587 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1635

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1636 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1754 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1803

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1860 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1908

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1964

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1965 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 2013 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2066

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2112

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2113 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2171

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2172 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2209

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2260

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2261 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2296

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2297 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2344

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2345 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2395

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2396 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2453

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2454 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2512

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2513 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2572 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2686

Query: 2724 QER 2726
              R
Sbjct: 2687 ARR 2689



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 429  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 488

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 489  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 548

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 549  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 607

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 608  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 663

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 664  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 723

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 724  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 783

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 784  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 843

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 844  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 903

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 904  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 958

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 959  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1019 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1059

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1060 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1116

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1176

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1232

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1582

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1643 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1751 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1804 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1856

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1916

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2094

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2153

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2208

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2263

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2319

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2320 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2368

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2369 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2472

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2473 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2522



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 388  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 444

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 445  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 504

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 505  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 548

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 549  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 603

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 604  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 656

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 657  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 716

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 717  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 766

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 767  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 798

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 799  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 844

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 845  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 901

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 902  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 956

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 957  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1016

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1076

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1133

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1188

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1308

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1366

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1427 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1538

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1589

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1590 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1636

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1637 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2107

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2164

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2214

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2215 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2236

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2237 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2288

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2289 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2326

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2327 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2376

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2377 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2416

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2417 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2455

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2456 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2496

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2606



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 527  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 586

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 587  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 643

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 644  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 703

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 704  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 763

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 764  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 819

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 820  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 879

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 880  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 939

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 940  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 999

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 1000 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1059

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1060 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1118

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1119 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1178

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1239 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1281

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1282 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1331

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1332 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1434

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1435 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1487 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1543

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1544 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1601 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1654

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1713

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1747

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1800

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1801 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1854

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1855 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1906

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2027 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2080

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2137

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2195

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2196 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2217

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2218 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2270

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2331 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2449 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2505

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2564 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2613

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2614 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2653

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2654 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2709

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2710 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2746



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 348  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 402

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 403  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 462

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 463  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 519

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 520  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 572

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 573  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 630

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 631  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 690

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 691  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 750

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 751  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 805

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 806  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 865

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 866  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 926  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 985

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 986  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1041

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1042 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1101

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1102 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1158

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1159 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1210

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1211 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1266

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1386

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1438

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1439 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1495 QAQEEAERL 1503



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 282  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 342  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 397

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 398  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 454

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 455  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 514

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 515  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 574

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 575  KIERARSDEGQL 586


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 42   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 98

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 99   KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 158

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 159  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 213

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 214  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 273

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 274  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 325

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 326  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 381

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 382  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 437

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 438  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 498  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 556

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 557  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 616

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 617  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 677  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 736

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 737  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 789  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 849  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 908

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 909  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 965

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 966  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1000

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1001 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1059

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1060 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1296 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1353 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1407

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1468 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1523

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1583 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1631

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1632 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1750 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1799

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1856 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1904

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1960

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1961 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 2009 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2062

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2108

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2109 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2168 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2205

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2256

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2257 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2292

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2293 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2340

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2341 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2391

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2449

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2508

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2509 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2682

Query: 2724 QER 2726
              R
Sbjct: 2683 ARR 2685



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 425  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 485  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 545  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 603

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 604  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 660  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 719

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 720  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 780  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 839

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 840  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 899

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 900  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 954

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1015 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1055

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1112

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1228

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1578

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1639 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1747 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1800 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1852

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2090

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2204

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2259

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2315

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2316 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2364

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2365 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2468

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2469 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 384  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 440

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 441  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 501  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 544

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 545  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 599

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 600  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 652

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 653  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 712

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 713  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 762

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 763  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 794

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 795  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 840

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 841  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 897

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 898  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 952

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 953  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1012

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1129

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1184

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1362

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1423 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1534

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1585

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1586 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1632

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1633 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2103

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2160

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2210

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2211 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2232

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2233 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2284

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2285 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2322

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2323 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2372

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2373 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2413 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2451

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2452 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2492

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2602



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 523  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 583  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 640  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 699

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 700  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 759

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 760  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 815

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 816  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 875

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 876  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 935

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 936  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 996  LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1056 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1235 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1277

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1278 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1328 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1430

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1431 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1483 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1539

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1540 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1597 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1650

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1709

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1743

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1796

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1797 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1851 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1902

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2023 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2076

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2191

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2192 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2213

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2214 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2266

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2327 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2445 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2501

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2560 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2610 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2649

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2650 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2705

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 344  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 398

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 399  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 459  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 515

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 516  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 568

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 626

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 627  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 686

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 687  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 746

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 747  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 801

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 802  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 862  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 922  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 982  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1037

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1038 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1154

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1155 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1206

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1262

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1434

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1435 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1491 QAQEEAERL 1499



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 278  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 338  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 393

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 450

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 451  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 510

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 511  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 570

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 571  KIERARSDEGQL 582


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 10   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 66

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 67   KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 126

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 127  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 181

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 182  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 241

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 242  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 293

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 294  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 349

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 350  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 405

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 406  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 465

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 466  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 524

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 525  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 584

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 585  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 644

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 645  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 704

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 705  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 756

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 757  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 816

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 817  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 876

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 877  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 933

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 934  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 968

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 969  TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1027

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1028 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1087

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1264 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1321 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1375

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1436 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1491

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1550

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1551 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1599

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1600 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1718 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1767

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1824 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1872

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1928

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1929 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 1977 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2030

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2076

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2077 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2135

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2136 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2173

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2224

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2225 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2260

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2261 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2308

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2309 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2359

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2360 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2417

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2418 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2476

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2477 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2536 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2650

Query: 2724 QER 2726
              R
Sbjct: 2651 ARR 2653



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 393  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 452

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 453  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 512

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 513  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 571

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 572  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 627

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 628  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 687

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 688  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 747

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 748  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 807

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 808  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 867

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 868  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 922

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 923  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 982

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 983  P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1023

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1024 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1080

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1140

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1196

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1546

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1607 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1715 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1768 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1820

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1880

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2058

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2117

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2172

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2227

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2283

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2284 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2332

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2333 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2436

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2437 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2486



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 352  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 408

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 409  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 468

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 469  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 512

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 513  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 567

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 568  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 620

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 621  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 680

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 681  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 730

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 731  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 762

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 763  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 808

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 809  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 865

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 866  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 920

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 921  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 980

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 981  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1040

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1097

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1152

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1272

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1330

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1391 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1502

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1553

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1554 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1600

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1601 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2071

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2128

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2178

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2179 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2200

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2201 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2252

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2253 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2290

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2291 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2340

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2341 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2380

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2381 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2419

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2420 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2460

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2570



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 491  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 550

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 551  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 607

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 608  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 667

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 668  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 727

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 728  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 783

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 784  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 843

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 844  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 903

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 904  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 963

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 964  LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1023

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1024 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1082

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1083 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1142

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1203 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1245

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1246 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1295

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1296 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1398

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1399 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1451 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1507

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1508 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1565 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1618

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1677

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1711

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1764

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1765 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1818

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1819 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1870

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 1991 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2044

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2101

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2159

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2160 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2181

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2182 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2234

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2295 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2413 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2469

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2528 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2577

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2578 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2617

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2618 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2673

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2674 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2710



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 312  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 366

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 367  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 426

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 427  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 483

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 484  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 536

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 537  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 594

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 595  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 654

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 655  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 714

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 715  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 769

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 770  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 829

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 830  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 890  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 949

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 950  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1005

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1006 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1065

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1066 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1122

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1123 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1174

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1175 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1230

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1350

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1402

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1403 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1459 QAQEEAERL 1467



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 246  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 306  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 361

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 362  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 418

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 419  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 478

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 479  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 538

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 539  KIERARSDEGQL 550


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 179  RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 235

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 236  KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 295

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 296  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 350

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 351  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 410

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 411  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 462

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 463  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 518

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 519  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 574

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 575  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 634

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 635  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 693

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 694  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 753

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 754  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 813

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 814  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 873

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 874  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 926  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 986  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1045

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1102

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 1103 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1137

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1138 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1196

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1197 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1256

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1433 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1490 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1544

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1605 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1660

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1719

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1720 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1768

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1769 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1887 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1936

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1993 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 2041

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 2097

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 2098 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 2146 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2199

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2245

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2246 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2305 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2342

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2393

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2394 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2429

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2430 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2477

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2478 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2528

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2529 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2586

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2645

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2646 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2819

Query: 2724 QER 2726
              R
Sbjct: 2820 ARR 2822



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 562  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 621

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 622  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 681

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 682  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 740

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 741  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 796

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 797  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 856

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 857  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 917  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 976

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 977  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 1036

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 1037 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 1091

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1152 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1192

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1249

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1309

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1365

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1715

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1776 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1884 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1937 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1989

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 2049

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2227

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2286

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2341

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2396

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2452

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2453 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2501

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2502 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2605

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2606 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2655



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 521  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 577

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 578  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 638  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 681

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 682  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 736

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 737  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 789

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 790  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 849

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 850  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 899

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 900  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 931

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 932  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 977

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 978  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 1034

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 1035 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 1089

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 1090 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1149

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1266

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1321

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1441

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1499

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1560 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1671

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1722

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1723 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1769

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1770 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2240

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2297

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2347

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2348 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2369

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2370 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2421

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2422 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2459

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2460 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2509

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2510 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2549

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2550 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2588

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2589 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2629

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2739



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 660  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 719

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 720  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 776

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 777  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 836

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 837  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 896

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 897  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 952

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 953  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 1012

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 1013 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 1072

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 1073 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1132

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 1133 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1193 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1251

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1252 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1372 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1414

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1415 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1464

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1465 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1567

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1568 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1620 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1676

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1677 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1734 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1787

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1846

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1880

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1933

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1934 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1987

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1988 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 2039

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2160 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2213

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2270

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2328

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2329 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2350

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2351 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2403

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2464 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2582 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2638

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2697 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2746

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2747 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2786

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2787 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2842

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2843 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2879



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 481  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 535

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 536  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 595

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 596  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 652

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 653  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 705

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 706  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 763

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 764  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 823

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 824  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 883

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 884  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 938

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 939  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 998

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 999  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1118

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 1119 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1174

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1175 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1291

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1292 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1343

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1399

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1519

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1571

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1572 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1628 QAQEEAERL 1636



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 415  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 475  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 530

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 531  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 587

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 588  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 647

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 648  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 707

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 708  KIERARSDEGQL 719


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 28   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 84

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 85   KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 144

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 145  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 199

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 200  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 259

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 260  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 311

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 312  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 367

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 368  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 423

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 424  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 483

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 484  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 542

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 543  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 602

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 603  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 662

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 663  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 722

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 723  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 775  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 835  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 894

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 895  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 951

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 952  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 986

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 987  TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1045

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1046 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1105

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1106 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1221

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1281

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1282 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1339 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1393

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1454 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1509

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1568

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1569 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1617

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1618 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1736 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1785

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1842 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1890

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1946

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1947 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 1995 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2048

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2094

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2095 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2153

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2154 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2191

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2242

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2243 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2278

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2279 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2326

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2327 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2377

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2378 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2435

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2436 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2494

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2495 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2554 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2668

Query: 2724 QER 2726
              R
Sbjct: 2669 ARR 2671



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 411  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 470

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 471  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 530

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 531  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 589

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 590  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 645

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 646  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 705

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 706  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 765

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 766  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 825

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 826  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 885

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 886  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 940

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 941  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1001 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1041

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1042 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1098

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1158

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1214

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1564

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1625 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1733 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1786 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1838

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1898

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2076

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2135

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2190

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2245

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2301

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2302 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2350

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2351 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2454

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2455 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2504



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 370  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 426

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 427  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 486

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 487  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 530

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 531  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 585

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 586  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 638

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 639  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 698

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 699  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 748

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 749  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 780

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 781  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 826

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 827  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 883

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 884  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 938

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 939  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 998

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 999  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1058

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1115

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1170

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1231 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1290

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1348

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1409 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1520

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1571

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1572 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1618

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1619 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1856

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2089

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2146

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2196

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2197 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2218

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2219 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2270

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2271 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2308

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2309 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2358

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2359 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2398

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2399 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2437

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2438 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2478

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2588



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 509  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 568

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 569  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 625

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 626  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 685

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 686  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 745

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 746  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 801

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 802  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 861

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 862  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 921

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 922  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 981

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 982  LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1041

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1042 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1100

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1101 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1221 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1263

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1264 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1313

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1314 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1416

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1417 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1469 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1525

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1526 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1583 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1636

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1695

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1755

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1756 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1729

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1782

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1783 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1836

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1837 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1888

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2008

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2009 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2062

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2119

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2177

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2178 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2199

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2200 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2252

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2313 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2431 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2487

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2546 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2595

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2596 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2635

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2636 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2691

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2692 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2728



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 330  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 384

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 385  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 444

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 445  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 501

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 502  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 554

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 555  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 612

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 613  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 672

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 673  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 732

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 733  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 787

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 788  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 847

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 848  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 908  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 967

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 968  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1023

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1024 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1083

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1084 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1140

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1141 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1192

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1193 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1248

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1309 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1368

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1369 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1420

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1421 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1477 QAQEEAERL 1485



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 264  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 324  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 379

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 380  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 436

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 437  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 496

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 497  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 556

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 557  KIERARSDEGQL 568


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  357 bits (917), Expect = 9e-98
 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 69   RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 125

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 126  KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 185

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 186  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 240

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 241  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 300

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 301  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 352

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 353  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 408

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 409  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 464

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 465  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 524

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 525  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 583

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 584  SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 643

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 644  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 703

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 704  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 763

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 764  QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 816  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 876  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 935

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 936  WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 992

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 993  QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1027

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1028 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1086

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1087 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1146

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+  + 
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262

Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
                +           QA L  ++  GE V E     +Q+    +++   L T   + E 
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322

Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
            + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+  E ++ +AE
Sbjct: 1323 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379

Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
              Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++  E++ R   
Sbjct: 1380 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1434

Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
                   +  IQ  LQ LR   EA  +    + +  +++             Q E   RQ
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494

Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
               A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A   +A  + A
Sbjct: 1495 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1550

Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
                  E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       AE       
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1609

Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             S+ E       L R  +E  V V   + + +R         A    +A+   E+ +   
Sbjct: 1610 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1658

Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
              W    +A EA    LQ     QQ  L  +E E   EE       R    ++A   R +
Sbjct: 1659 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716

Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
             + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ  AA    +
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776

Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
             +ELE      E  +   +++  LAS+ +A +   S  E  +  L    +  +F+   E+
Sbjct: 1777 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1826

Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
              +      L  E+  +R  +     RQR +    A   L E   A G A R  TE  + 
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
            +     E      E+   L  + A     LE Q   H+         E +L +L + +  
Sbjct: 1883 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1931

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
              +   G     ++QR+Q   +  A+     +    + E    L R R+   D      R
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1987

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
             ++  ++E + Q            + L AE E R +  ++  Q    A   A    K   
Sbjct: 1988 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
            EE+  L+ + ++      R +ER + E   QL L +    + + A  E      A+    
Sbjct: 2036 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2089

Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
            +E++Q +++ +  L  L  + +   A R   +     RV+             +E A+SR
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2135

Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
                 A  L  S  + A QA    QA A++L++       R    +   L + QA +AE+
Sbjct: 2136 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2194

Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
            + H+       K  E  L Q      +V Q L  LR           L+ +E + ++N L
Sbjct: 2195 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2232

Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
             E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         +    A I 
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2283

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
               D + +    + E++K                        Q  E A  + V ++E   
Sbjct: 2284 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2319

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++     + + 
Sbjct: 2320 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2367

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
            E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A+RL+   A+
Sbjct: 2368 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2418

Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
            M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   + H  +  +R
Sbjct: 2419 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2476

Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
            + +A LE+E   L              +   QE  LQ  QAL+ Q FLS   S+ + ER+
Sbjct: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2535

Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
            +  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R  H+   G  
Sbjct: 2536 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594

Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
              Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+ +     + 
Sbjct: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654

Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
                 LD     A+       L+++ + Q   +A +   +ELQR  Q     GH   + +
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2709

Query: 2724 QER 2726
              R
Sbjct: 2710 ARR 2712



 Score =  177 bits (450), Expect = 1e-43
 Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)

Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 452  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 511

Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 512  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 571

Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 572  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 630

Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 631  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 686

Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 687  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 746

Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 747  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806

Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 807  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 866

Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 867  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 926

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 927  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 981

Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 982  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041

Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 1042 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1082

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1139

Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
            KE                             P  D LRD+L+           +H   + 
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1199

Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
            EV+   E +  + ++ +A+LAQ+  R  E+ Q  + LR +    R++    G  L+D R 
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1255

Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
              E +Q + LA++        QE+ +   +   G+ +E C               LQL  
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315

Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
             + +L      +    V    ++ I+   DL                       R  EE 
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375

Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
            ++  Q+R++   R A     L + +Q  E   +    + RE   + +R+QE+     EA 
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435

Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
            + A    + ++   + LR+  E                   +E E+  ++ Q+E+ ER+ 
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
            G        L  R+ EA    R  Q+E      Q++  +Q++R+A   L    K +A   
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555

Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
               Q  L + + LR Q + +       E  R     ++ +  L++        RS   +L
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1605

Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
             +    F+    Q+   L++E  ++    +E + + QQ  E +      E+ +ERW    
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665

Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
             ++L      + +A  + L             QA      E   R   + G  E Q+   
Sbjct: 1666 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713

Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
            R  A    ++      GT + RL   +EL +L+A  +  ++    L E+      E    
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
            T       QK+Q  +AEL     + + L     R  +     SE  ++RLE     + EL
Sbjct: 1774 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826

Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
             + +    A+L+   E  + +R + E +   +  E E     + + L  +GE    + E 
Sbjct: 1827 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1879

Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
            E A+ +K  + E L  L + +AF R       AQ   D+EE+  +L       L+R K L
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1939

Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
             E    +R  +E   L LK                    R   E+    +E+  L AA+ 
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
               +    R  +E  + ++  +++ E  A  R       + ++A    A  +  R +Q  
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059

Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
                 L  EAA++RL  ++   A     +  E    L +   VLD   +   AEA +   
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2117

Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
               E  +   E  + +  R  + A  L+     E  +  AQ QA      +EA  E  RR
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2176

Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
            A+A    L++      +++ H     Q  R+   ++  LTT     E  D+ ++L     
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2231

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
            L+E+    + E     + +     +L     +        +   ++RIEA    L    K
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2286

Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
              T+      A ++    + AA L    QE   L +  +    L+  R L +  + L+ +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2342

Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
            ++A++ E  RL+ EA  L Q    A       QE    LQ   ++  Q LA+  QG    
Sbjct: 2343 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2391

Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
               Q  L   ++RQ   S+E        AE+L  +  E+ +        AQ  R++ +++
Sbjct: 2392 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440

Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
             +  H     + E    +Q LE + Q+ +       +  AE   L++ +++L+Q EA L 
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2495

Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
                L LK +   +V   +LL     L +    EK    Q E+F + +K ++EQ
Sbjct: 2496 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2545



 Score =  167 bits (422), Expect = 2e-40
 Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)

Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
            L+ + E L+ L + V +   +    + +     + LQ   +LL   +  Q   R+ EV  
Sbjct: 411  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 467

Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
            D+  A  ++R               + + +   ++   ERL  +  +   +  A +  P 
Sbjct: 468  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 527

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
            +Q    TL    Q  Q    L +   ++LQ+ L  +++    VDG          W    
Sbjct: 528  TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 571

Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
              G D+    + L  HR   + +     + E  R+   +L  +   A    R+ L  +  
Sbjct: 572  --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 626

Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
            Q+ +L   S+ R R L +   L  +     + + W+ EK      E  G   + RN   T
Sbjct: 627  QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 679

Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
             K+  + A   EL    + ++ LQ  G  LL      +  +++    L+++W  + +   
Sbjct: 680  AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 739

Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
                 L++     Q    +++A+ QL++L+ AL+   +     +  RL+           
Sbjct: 740  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 789

Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
                                 +L++ Q    +L   +GHL+    + +A V+L       
Sbjct: 790  ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 821

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
                           P      + G   L       QVEV  H+G   +++     S  +
Sbjct: 822  --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 867

Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
             L++SG   A  +   C  +     E + A   R +   QA+   + Q  +D+  L  W 
Sbjct: 868  VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 924

Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
              +R +   R +      TL+   + QAL   L +++ +     Q A    G   PE + 
Sbjct: 925  SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 979

Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
            + +          Q+L  + ++  +   R    + E +D++  L + +        L  D
Sbjct: 980  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1039

Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
             E A     + A+ Q  Q E+        RL AE+     L     A P +R        
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099

Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
              ++ + L   + E  +         +  E  LR H    E L + Q    +LP   A  
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1156

Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
              L  L AQ  + Q     L  EL G +   + L +  G         +    ++R   +
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1211

Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
             + W  +  + + R+ +LE+  R L  +R +     +W   AR RQ+        +  + 
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271

Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
              +L   Q L  E+E   +  ++  +  +Q + A                   +P K+  
Sbjct: 1272 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1331

Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
                    +QE         EL  L  Q  + + +T  R +E  +  +Q++   RE  RL
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1389

Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
             E+ AA E           A   +  E ++L ++   EV  +   A D  +++ +++E L
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449

Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
            + LR+    +     +Q + R  E AE     +   + +      AT+     AE  +QA
Sbjct: 1450 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
               + +E        +++ + L +    E++ +   EV  +   K EA  A+   RA   
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1561

Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
             Q L+ LR   E+    LRQA   R ++++     LE  QR   AEA +Q K        
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1612

Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
                 E   QL R L+E       + V  A +R  ++   Q +  + E  +   +R  + 
Sbjct: 1613 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1659

Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
              RW       LR + Q E   +   L++        E +   +R        ++++E  
Sbjct: 1660 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717

Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
             Q L+  + L    + QRL  + E   L  E    + Q + LE E+ RL + +  A    
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777

Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
            +  + E+A    E    L S+A+   E+     ++ Q+L+A     +EL   A RLRA  
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1837

Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
            + +   R   E  A R   E +   AE  +     +  ++  +  L      +  +R++ 
Sbjct: 1838 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1897

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
                 +   LE    +H+  +++ L  QL  +S  ++ER     ED+L     + + +  
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956

Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
            ++    K    + +LE++ G+I S  E T R   Q     A+      +    R+EA  R
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016

Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
               +     E  RQ +A L++ + + A + E + L    E      +  AQ   Q+  QA
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076

Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
            E  A     Q+ ++E Q+ LQ      + ++   E       E ++      A++Q   E
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2130

Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
            A + RR +EE E   +  E + +A    QA     E L  + E EAA   +A QA     
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2187

Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
            QA     E H   A+    Q  ++ Q   +LR  L+E       ++LL       DEE+ 
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2237

Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
             ++ +   AA                Q   +E E+ S                       
Sbjct: 2238 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2259

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
                 RVQ  E +    R EA  R L+L+     Q+FL E  E    +AE    L     
Sbjct: 2260 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2311

Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
               A    A LR+L              E L Q  AL E         +  ++QAV+EA 
Sbjct: 2312 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2349

Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
                 R +A    LQ+Q +L Q +   L  D     +    E+Q + + LE  +      
Sbjct: 2350 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2399

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
               +++++   +A+   LR                  A+ SR +A  E   Q  + + E 
Sbjct: 2400 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2439

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
            +    ++H  + A        QEK  L            V+TL+ Q ++ + + E + + 
Sbjct: 2440 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2478

Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
            +A L+ E                K+Q+    LQ K++E      Q  Q    L   Q L 
Sbjct: 2479 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2519

Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
             ++  E+  L   E   E + A  EQL        Q++R E + Q Q + QE Q+LV   
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579

Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
            + +     E  E ++  +  LQ+LE+    + +  AE    Q+LR++L+  E
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2629



 Score =  108 bits (269), Expect = 1e-22
 Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   +A++E    + G+L
Sbjct: 550  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 609

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
               SP      R     +   + +L + ++ R  +L++LH                    
Sbjct: 610  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 666

Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
                          + +   A+++EL +  ++++   +      R    AR  +E  Q  
Sbjct: 667  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 726

Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
                 SW   +        +   A   F SD+R+    L++                ++ 
Sbjct: 727  LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 786

Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
            LE   Q+ Q + +Q  E +  LS + K  + +   +    +     P+    PLL     
Sbjct: 787  LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 842

Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
             + ++ V  G    L   A+  H                       + EAQ A+ R +A 
Sbjct: 843  KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 902

Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
                             LL  ++L R          A  R  + EE RQ         QA
Sbjct: 903  HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 962

Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
            FL+DSQ+   +  E  L+A                 LE+G  + +               
Sbjct: 963  FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1022

Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
                         LP           ++ +QQ  QAE++        L  E +++L    
Sbjct: 1023 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082

Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
            P+  A   R  EL    G+L+         L+K      + R  +  E  L   E +L+ 
Sbjct: 1083 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1141

Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
            A  V   LP +     + ++L A  + +    +AL  + +     G  L Q     DVE 
Sbjct: 1142 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1201

Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
                E+  +LL+R++++      R+  LE     L+++R+ AD   AW+Q         +
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
             +PLA +Q       AVR    Q Q L  E+  H          G K+ +   FA   + 
Sbjct: 1262 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1304

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
            A ++  E  +   +A+      L   A  A++     +++GS    + +V          
Sbjct: 1305 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1354

Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
              T   ++ +  T R +E      ERL +     E  +  E    L + + + EAHA+  
Sbjct: 1355 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410

Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
             +AE     LQ+++Q   + RE   +DA    ++   E Q   Q  E             
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1457

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
                    A++ A  + A   ER   R    I+  R ++EA   +        QA++AR 
Sbjct: 1458 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509

Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
            E   A  +    Q+ A  L+ ++Q+++   K +      S V+   +  R  +R L+A+E
Sbjct: 1510 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1566

Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
            +   RLQ E     +L  A      +VQ A  T Q  A+ E     A  A+  A L R  
Sbjct: 1567 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623

Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
             +E +A AQ R+E   +E  A+  A AE+     EE  +E+   +L+A +   LR + ++
Sbjct: 1624 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1677

Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
            +        AE  +  +E   E R +   E  A+R +  AE   L+K RQ  E  A+  L
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1736

Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
            A  + L+ L+ +        +LL      L++  AA    ++E  A++ K   E E+LL 
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796

Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
             +      + S+    + R     G   +LAE
Sbjct: 1797 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828



 Score =  105 bits (262), Expect = 8e-22
 Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)

Query: 277  EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
            E+   +L RW  +    L  R   + +   + L  A    + +E     ++RG AE    
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711

Query: 337  RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
            R +   + +  +     EG          EL +  A  E  E  R Q L++ L +LQR  
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1770

Query: 391  TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
              A + + +     + ++   +VL   +ARA   S +T E + QRL   EA    + GRF
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1823

Query: 449  QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
            + LAE A  LR     + A+ A+RQ ++        Q  + +R   +++A +     L  
Sbjct: 1824 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1877

Query: 506  EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
            E E A  + E   E  R      +LAE     +R   LE Q + H A +   LAQ     
Sbjct: 1878 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1929

Query: 565  DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
            DS L     +++   R   Q+++ ++AL     +A     E  L+      N E+     
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1989

Query: 616  EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
            E+A L+   QR   A   R   +    +QK  A E E  R +   ++ V R   +   AR
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2049

Query: 674  RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
            R   + +  E A  +Q   +  Q R+  +      A  V Q      E    L++ +S L
Sbjct: 2050 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2103

Query: 734  E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
            +  R      + AAE      V+ ER     A   R++EE  R   +        +    
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2160

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              E LR       A        A +    A+ + +       QT    +Q  + L  L  
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2218

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
              R +LEE                  + Q  LL          E+ +LK           
Sbjct: 2219 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2240

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
                AE + +A Q R +       ++ Q EELS+   ++EA  R  A+ L        FL
Sbjct: 2241 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2293

Query: 972  QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
            QE      Q+ +   +L  A Q  +         LAQ++ L  +     +Q+V       
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353

Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
              AE++ LQ Q E  Q   +++QE   Q A++ AE TQ  Q  L+    +QL + AE+ +
Sbjct: 2354 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
             +LR  E+S   A     AQR  ++ +++ E++H      QE++   Q L+ Q Q     
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471

Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
                   +A L+  + +++    ++L  + +E++ +  Q++Q LQE   LQ+ F  E D 
Sbjct: 2472 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2528

Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                     Q    L+ L +D  E     Q   E  R    +    + L A  E+  + Q
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
            H A   VR + +        LQ   +QRR+Q      L E  Q + E +Q +EE+   A 
Sbjct: 2587 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2636

Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
            AH                E   S++ AT+         GR+ L   P  + + +    GL
Sbjct: 2637 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2676

Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            R K  A  +++ E G    +ELQ+  Q    + +L   ++    L+G  +SS  G  L++
Sbjct: 2677 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2732

Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
            +      +  L+ +  +    +  L A  A G    P
Sbjct: 2733 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2769



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 371  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 425

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 426  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 485

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 486  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 542

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 543  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 595

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 596  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 653

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 654  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 713

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 714  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 773

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 774  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 828

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 829  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 888

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 889  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 949  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1008

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 1009 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1064

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1065 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1181

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 1182 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1233

Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1289

Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 1350 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1409

Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1461

Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 1462 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517

Query: 3446 KTEMEQELL 3454
            + + E E L
Sbjct: 1518 QAQEEAERL 1526



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 305  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 365  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 420

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 421  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 477

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 478  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 537

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 538  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 597

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 598  KIERARSDEGQL 609


>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score =  346 bits (887), Expect = 3e-94
 Identities = 203/553 (36%), Positives = 310/553 (56%), Gaps = 22/553 (3%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  +G+ L+ LLE+ISGE LP P RG++R H
Sbjct: 38  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFH 95

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL ++ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 96  KIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 151

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVNI +F  SW DGLG  ALIH HRPDL+DY  L  D
Sbjct: 152 -----SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKD 206

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            P+ N+  A  +AE+ L I ++LD ED+    +PDER+IMTYVS +YH  +   Q +T  
Sbjct: 207 DPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAA 266

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L  +YE+L ++LL WI      LE R    ++ AM++ L  F  +
Sbjct: 267 NRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDY 326

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R + KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE AE    
Sbjct: 327 RRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE 386

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
           + L   + +L+RLE LA +F+ KA+  E++    EQ+L Q     ASL  V A +++   
Sbjct: 387 EWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEA 446

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            E+ +   + R + +A IA  L +  YH   +V  R +++  +W RL    Q +R+ +  
Sbjct: 447 FESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER 506

Query: 497 MQAVLSLLQEVEAA--------SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQV- 547
           M+ +L  + ++           ++ +E   E  +       + E+  L+  H+  +A + 
Sbjct: 507 MEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566

Query: 548 SAHGAHVSHLAQQ 560
            A G   S +A Q
Sbjct: 567 EADGERQSIMAIQ 579



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 68/307 (22%), Positives = 125/307 (40%), Gaps = 28/307 (9%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852
            Q + +  ++    Q +  +    AF+     +  D+    +RL Q  K   E  L E R 
Sbjct: 336  QEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRR 395

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY-GQSLSAVRHLQEQHQNLESEMSSHE 2911
                  L  KF + A     W   K  +   +DY   SL+ VR L  +H+  ES++++H+
Sbjct: 396  LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  +  A  V  R Q++      L     +RR  L++ ++  + + 
Sbjct: 456  DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515

Query: 2972 EL--------LEAGSWLAERGHVLDSEDM--GHSAEATQAL----------LRRLEATKR 3011
            +L            +W+   G + D +DM   HS E  Q+L          L   +  ++
Sbjct: 516  QLHLEFAKRAAPFNNWM--EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573

Query: 3012 DLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL- 3070
             + A    +E++ Q+  +  S  NP S   + +L+   +   +L+     R   LQE+L 
Sbjct: 574  SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLV---PIRDQSLQEELA 630

Query: 3071 QLHQLER 3077
            + H  ER
Sbjct: 631  RQHANER 637



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 65/280 (23%), Positives = 120/280 (42%), Gaps = 36/280 (12%)

Query: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEE-ILAAQEVSLKTSALGSSVEE 2048
            +Q ++ Y+ W     R+ ERL  E   + F ++    E      +++ L+     +S+ E
Sbjct: 379  EQAEKGYEEWLLNEIRRLERL--EHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436

Query: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102
            V  L+RKHE F   L A QD+ E  AA+ + L  L       V DR   +  +  R+  L
Sbjct: 437  VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496

Query: 2103 AESRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154
             + R  AL            L   F + A    +W++   + L++      + +    + 
Sbjct: 497  TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556

Query: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ----RLQGLRKHWEDLRQ 2207
             H+ F+A   E     + + ++  + E ++   + R    +      +  LR  W+ ++Q
Sbjct: 557  AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616

Query: 2208 AMALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239
             + +R Q L++   R++  E L+R   A+A     WIQ K
Sbjct: 617  LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK 656



 Score = 53.1 bits (126), Expect = 5e-06
 Identities = 69/294 (23%), Positives = 116/294 (39%), Gaps = 55/294 (18%)

Query: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAW--------LHLDNLGEDVR 1206
            Q L+   +  ++WL  E   L++     + F    + H+ W        L  D     + 
Sbjct: 376  QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLT 435

Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
            E  +LL++H  F   L+    R E + A  ++L +  +  A  V ++ Q I  QW RL G
Sbjct: 436  EVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL-G 494

Query: 1267 RSEQRRRQLLASLQ-------------------LQEWKQDVAELMQWM-------EEKGL 1300
               Q+RR+ L  ++                      W +   E +Q M       E + L
Sbjct: 495  TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554

Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVE-ALQQVGRELLSRRPCGQEDIQTRL 1359
            + AHE   A      TL   +     ++A +  VE  +Q     + S  P         +
Sbjct: 555  ITAHEQFKA------TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS----TVTM 604

Query: 1360 QGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
              LR+KW+ + + +  R   L     QE+L R  Q A E+L + + A Q++  G
Sbjct: 605  DELRTKWDKVKQLVPIRDQSL-----QEELAR--QHANERLRR-QFAAQANAIG 650



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 54/232 (23%), Positives = 98/232 (42%), Gaps = 33/232 (14%)

Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
            E L+ +     W++ +  +  +  + + LE         R++R       V + C   I+
Sbjct: 292  ELLEWIRRTIPWLENRTPEKTMQAMQKKLED-------FRDYRRKHKPPKVQEKCQLEIN 344

Query: 2284 DLSLQLKNRD-------PEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
              +LQ K R        P E K++    S +   W         Y++ L    EI  L R
Sbjct: 345  FNTLQTKLRISNRPAFMPSEGKMV----SDIAGAWQRLEQAEKGYEEWLLN--EIRRLER 398

Query: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384
             L+++ ++ ++K +  +    GK+            L  V+ LLRKHE  E ++   Q +
Sbjct: 399  -LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457

Query: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436
            VE +      L +     A  +  R Q++ + W +L +  QKRREAL+ + +
Sbjct: 458  VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 78/400 (19%), Positives = 163/400 (40%), Gaps = 56/400 (14%)

Query: 1013 LERRVHFLQSVVVKVEEPGYAESQ-----PLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
            LE   + LQ+ +     P +  S+      + G  + L+   K  +E +    RR    +
Sbjct: 341  LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400

Query: 1068 -ARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               + F Q++     WA   +  L  K+  S  +   + LLR+H+    ++   Q+R++Q
Sbjct: 401  HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVD-- 1183
            + A +Q +  LD  D+  V +  + +  Q   L  L ++R++ L+    ++K    +D  
Sbjct: 461  IAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQL 517

Query: 1184 --GFTATCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA 1234
               F    A    W+   +++L +      + E  SL+  H +F   L       +++ A
Sbjct: 518  HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMA 577

Query: 1235 ---HGEKLVQ-------SQHPAAHTVREQL---------------QSIQAQWTRLQGRSE 1269
                 EK++Q       S +P +    ++L               QS+Q +  R Q  +E
Sbjct: 578  IQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR-QHANE 636

Query: 1270 QRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLA 1329
            + RRQ  A          +   +Q   E+   ++ + +GA  + +  LK++   E  ++ 
Sbjct: 637  RLRRQFAAQANA------IGPWIQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIIN 687

Query: 1330 TRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
             + +++ L+   + +        +     ++ +R  WE L
Sbjct: 688  YKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELL 727



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 72/398 (18%), Positives = 146/398 (36%), Gaps = 38/398 (9%)

Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557
            + W+    P  +  +  + L   +   RKHK  +V+ K         L +   L  S  P
Sbjct: 301  IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQT--KLRISNRP 358

Query: 1558 QAQHIV-EQCQELEGHWAELERACEARAQCLQQAV--------TFQQYFLDVSELEGWVE 1608
                   +   ++ G W  LE+A +   + L   +          +++    S  E W  
Sbjct: 359  AFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAY 418

Query: 1609 EKRPLVSSRDYGRDEAATLR-LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
             K  ++  +DY       +R L+ KH+A + +LA +   +E++   AQ L   +  +   
Sbjct: 419  GKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVN 478

Query: 1668 VVQ---------ERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717
            V           +RL    +  +E     ++ LE   +LH EF + A     W+    + 
Sbjct: 479  VNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMED 538

Query: 1718 AKGGESLGEDPEHALHLCTKFAKFQ---HQVEMGSQRVAACRLLAESLLE----RGHSAG 1770
             +    +    E    L T   +F+    + +   Q + A +   E +++    R  S+ 
Sbjct: 539  LQ-DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597

Query: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822
            P       +L+T W ++ +L   R  +L++       +  L              +Q K 
Sbjct: 598  PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657

Query: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
              +  +  +    LE Q+   +  E  ++  +  + +L
Sbjct: 658  EEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKL 695



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 71/322 (22%), Positives = 130/322 (40%), Gaps = 36/322 (11%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 337  EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE-EWLLNEIRR 395

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
             + LE   + F       E W   KE  L  +      L  +  LL KH+  E DL    
Sbjct: 396  LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL----- 2649
             ++  + A A+ L++  + +A +   RCQ +  + + L      RR  LE + +L     
Sbjct: 456  DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515

Query: 2650 QAFLQDSQEVAA---WLREKNLVALEEGLLDTAM--LPAQLQKQQNFQA---ELDASMHQ 2701
            Q  L+ ++  A    W+ E  +  L++  +  ++  + + +   + F+A   E D     
Sbjct: 516  QLHLEFAKRAAPFNNWM-EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574

Query: 2702 QQELQREGQRLLQ-------GGHPASEAIQERLEELGALWGE------LQDNSQKKVAKL 2748
               +Q E ++++Q         +P S      ++EL   W +      ++D S ++    
Sbjct: 575  IMAIQNEVEKVIQSYNIRISSSNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELAR 631

Query: 2749 QKACEALRLRRSMEELENWLEP 2770
            Q A E  RLRR      N + P
Sbjct: 632  QHANE--RLRRQFAAQANAIGP 651



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 61/273 (22%), Positives = 106/273 (38%), Gaps = 30/273 (10%)

Query: 3153 SRIEAAWERLDQAIKARTENL--------AAAHEVHSFQQAAA--ELQGRMQEKTALMKG 3202
            S I  AW+RL+QA K   E L           H    F+Q A+  E     +E+  L K 
Sbjct: 369  SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428

Query: 3203 EDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL--HPA--APGGLAKVQ 3258
             +   SL+ VR L ++H   E +L A +  V ++   A  L +L  H A        K+ 
Sbjct: 429  YESA-SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487

Query: 3259 EAWATLQAKAQERGQWLAQAA-------QGH-AFLGRCQELLAWAQERQELASSEELAED 3310
            + W  L    Q+R + L +         Q H  F  R      W +   E      +   
Sbjct: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547

Query: 3311 VAGAEQLLGQHEELGQEIREC---RLQAQDLRQEGQQLVDNSHFMSAE----VTECLQEL 3363
            +   + L+  HE+    + E    R     ++ E ++++ + +   +      T  + EL
Sbjct: 548  IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607

Query: 3364 EGRLQELEEAWALRWQRCAESWGLQKLRQRLEQ 3396
              +  ++++   +R Q   E    Q   +RL +
Sbjct: 608  RTKWDKVKQLVPIRDQSLQEELARQHANERLRR 640



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 36/131 (27%), Positives = 62/131 (47%), Gaps = 11/131 (8%)

Query: 3330 ECRLQAQ-DLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEA------WALRWQRCA 3382
            +C+L+   +  Q   ++ +   FM +E  + + ++ G  Q LE+A      W L   R  
Sbjct: 338  KCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396

Query: 3383 ESWG--LQKLRQRLEQAEAWLACWEGLLLKPDY-GHSVSDVELLLHRHQDLEKLLAAQEE 3439
            E      +K RQ+    E W    E +LL+ DY   S+++V  LL +H+  E  LAA ++
Sbjct: 397  ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQD 456

Query: 3440 KFAQMQKTEME 3450
            +  Q+     E
Sbjct: 457  RVEQIAAIAQE 467



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 68/353 (19%), Positives = 148/353 (41%), Gaps = 65/353 (18%)

Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
            +D R  +R  K  +     QLE    TL  K         M +   M   +A +   LE+
Sbjct: 321  EDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ 380

Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             +K         +RRLE L+ HLA +  Q  ++   H+       ++    ++       
Sbjct: 381  AEKGYEEWLLNEIRRLERLE-HLAEKFRQKAST---HETWAYGKEQILLQKDY----ESA 432

Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
            S TE     ++L RKH+  + ++ AHQ +V+++ +  + L    +  A ++ ++CQ++  
Sbjct: 433  SLTE----VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488

Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
             W  L    + R + L++     +  +D   LE + +   P  +  +   ++   + +++
Sbjct: 489  QWDRLGTLTQKRREALERMEKLLE-TIDQLHLE-FAKRAAPFNNWMEGAMEDLQDMFIVH 546

Query: 1632 KHQALQEELAI---YWSSMEELDQTAQTLTGPEVPEQQRVVQ-----------------E 1671
              + +Q  +     + +++ E D   Q++   +  E ++V+Q                 +
Sbjct: 547  SIEEIQSLITAHEQFKATLPEADGERQSIMAIQ-NEVEKVIQSYNIRISSSNPYSTVTMD 605

Query: 1672 RLREQLRALQELAATRDRELEGTL-RLH-------EFLREAEDLQGWLASQKQ 1716
             LR +   +++L   RD+ L+  L R H       +F  +A  +  W+ ++ +
Sbjct: 606  ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKME 658



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 62/334 (18%), Positives = 131/334 (39%), Gaps = 45/334 (13%)

Query: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPA---RSTACGQQ-- 529
           ++   WQRL Q  +G  + +      L+ ++ +E   H  E+ ++ A    + A G++  
Sbjct: 370 DIAGAWQRLEQAEKGYEEWL------LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQI 423

Query: 530 ----------LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKA 579
                     L EV  LL++H+  E+ ++AH   V  +A    EL+         +  + 
Sbjct: 424 LLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRC 483

Query: 580 RTLAQLQQSLVALVRARRALLE------QTLQR--AEFLRNCEEEEAWLKECGQRVGNAA 631
           + +      L  L + RR  LE      +T+ +   EF +       W++   + + +  
Sbjct: 484 QKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543

Query: 632 LGRDLSQIAGALQKHKAL-----EAEVHRHQAVCV--DLVRRGRDLSARRPPTQPDPGER 684
           +   + +I   +  H+       EA+  R   + +  ++ +  +  + R   + P     
Sbjct: 544 IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603

Query: 685 AEAVQGGWQLLQTRVVGRGARLQTAL--------LVLQYFADAAEAASWLRERRSSLERA 736
            + ++  W  ++  V  R   LQ  L        L  Q+ A A     W++ +   + R+
Sbjct: 604 MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARS 663

Query: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
           S  Q   A E  + +  + E  +  +   + +LE
Sbjct: 664 SI-QITGALEDQMNQLKQYEHNIINYKNNIDKLE 696



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 80/432 (18%), Positives = 159/432 (36%), Gaps = 56/432 (12%)

Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN------ 1631
            R C+  A   +     ++Y    SEL  W+    P + +R   +   A  + +       
Sbjct: 268  RICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYR 327

Query: 1632 -KHQA--LQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678
             KH+   +QE  +L I ++++    QT   ++     +P + ++V +      RL +  +
Sbjct: 328  RKHKPPKVQEKCQLEINFNTL----QTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEK 383

Query: 1679 ALQELAATRDRELEGTLRLHE-FLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              +E      R LE    L E F ++A   + W   ++Q     +           L  K
Sbjct: 384  GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
               F+  +     RV     +A+ L E  +     V  R Q +   W  L  LTQ R  A
Sbjct: 444  HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503

Query: 1798 LRDTETTLRVHRDLLEVLTQVQ---EKATSLPNN-------------VARDLCGLEAQLR 1841
            L   E        LLE + Q+     K  +  NN             +   +  +++ + 
Sbjct: 504  LERME-------KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556

Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901
            +H+  +  L   + + Q ++     V+K+        +Q     ++ +       M++ R
Sbjct: 557  AHEQFKATLPEADGERQSIMAIQNEVEKV--------IQSYNIRISSSNPYSTVTMDELR 608

Query: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP-LKLSAHQWLRAELEAR 1960
             + ++ + L   R              + L+ + ++Q  + GP ++    +  R+ ++  
Sbjct: 609  TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT 668

Query: 1961 EKLWQQATQLGQ 1972
              L  Q  QL Q
Sbjct: 669  GALEDQMNQLKQ 680



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 45/238 (18%), Positives = 95/238 (39%), Gaps = 8/238 (3%)

Query: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
           G   Q+R   L ++   L+  + L  ++ +  A    W+      L+      S+  ++ 
Sbjct: 494 GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553

Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--PFLPHEGLGLAELSQCWA 366
           L+ A   F+    P    +R +  A+   ++  +Q+ N R     P+  + + EL   W 
Sbjct: 554 LITAHEQFKAT-LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWD 612

Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
            ++     R Q+LQ+ L +    E L R+F  +A     ++++  + +  AR+       
Sbjct: 613 KVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI--ARSSIQITGA 670

Query: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLL 484
           +E  + +L   E  I+  +     L     ++++             E + V W+ LL
Sbjct: 671 LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728



 Score = 33.1 bits (74), Expect = 5.2
 Identities = 61/336 (18%), Positives = 134/336 (39%), Gaps = 37/336 (11%)

Query: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIE-VELRAPTVGQA 2783
            +RLE+    + E   N  +++ +L+   E  R + S  E   W    E + L+      +
Sbjct: 376  QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHE--TWAYGKEQILLQKDYESAS 433

Query: 2784 LPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843
            L  V  LL      E+ +     + E +   AQ      +  A +V ++ +++  ++  L
Sbjct: 434  LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL 493

Query: 2844 REPLQERRTALEARSLLLKFFRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRH 2895
                Q+RR ALE    LL+       E A        W++  +          S+  ++ 
Sbjct: 494  GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553

Query: 2896 LQEQHQNL-----------ESEMSSHEALTRVVLGTGYKLVQAGHFAA---HEVAARVQQ 2941
            L   H+             +S M+    + +V+     ++  +  ++     E+  +  +
Sbjct: 554  LITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDK 613

Query: 2942 LEKAMAHLRAEAARRRLLLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EA 2998
            + K +  +R ++ +  L  Q A E   +QF  +    G W+  +      E++  S+ + 
Sbjct: 614  V-KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK-----MEEIARSSIQI 667

Query: 2999 TQAL---LRRLEATKRDLEAFSPRIERLQQTAALLE 3031
            T AL   + +L+  + ++  +   I++L+    L++
Sbjct: 668  TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQ 703


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  345 bits (885), Expect = 5e-94
 Identities = 762/3642 (20%), Positives = 1389/3642 (38%), Gaps = 526/3642 (14%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KTFTKW+N      +    I +LY +L DG +L+ LLE++SG  LP   +GR+R H
Sbjct: 78   RVQKKTFTKWVNKHLM--KVRKHINDLYEDLRDGHNLISLLEVLSGIKLPR-EKGRMRFH 134

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL FL+ + V +  I  ++I DG+  L LGLIW IIL FQIS I +  E    
Sbjct: 135  RLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDM 194

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            SA     KE LL+W Q+ TA YT +  T+FS  WSDG  FNALIH +RPDL+D   ++  
Sbjct: 195  SA-----KEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQ 249

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
                NL  AF VAE+ LG+ +LLD EDV    PDE+S++TYVS  Y    ++ +G     
Sbjct: 250  SNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEG-- 306

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                  +   E +    +Y+  V  L+ WI +  + +  + FP +   ++ L   +  F+
Sbjct: 307  ------ISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK 360

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
              E   + +++G  E L   L+  ++    R  LP +G    ++ + W  L      R +
Sbjct: 361  ETEILAKEREKGRIEELYKLLEVWIEF--GRIKLP-QGYHPNDVEEEWGKLIIEMLEREK 417

Query: 378  ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
            +L+  + +L+ L  +A + Q+ A   E  L  A+  L    A   S   V+     +  +
Sbjct: 418  SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477

Query: 438  EAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ----------- 481
            +      EG  + L     ILR E Y+   ++A R      E VT+R +           
Sbjct: 478  Q----ECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT 533

Query: 482  ---------RLLQHLQGQ--------------RKQV--ADMQAVLSL-----LQEVEAAS 511
                         HL+ +              RK +  A++ A+ S      L+ V    
Sbjct: 534  SLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELL 593

Query: 512  HQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTS 571
              +EE+Q        G  L  V   L+    +   V   G+ V        ++  +  TS
Sbjct: 594  SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS 653

Query: 572  VEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAA 631
                   A TL +L+     L       +       +F+     E  WL E  +      
Sbjct: 654  Y------AETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707

Query: 632  LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGG 691
               + S I+        L  E+   Q V   L      LS    P +      + AVQ  
Sbjct: 708  WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767

Query: 692  WQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA-SCGQDQAAAETLLR 750
             Q ++   +     ++      Q+F+DA E  S+LR  + S++R  SC  + + +     
Sbjct: 768  LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLS----- 822

Query: 751  RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP--PGESLRNPGPWSEASCH 808
               RLE +L+    E  +L +   + ++          L P  P   L+N          
Sbjct: 823  ---RLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKN---------- 869

Query: 809  PGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCS 868
                    +++ A  D      TI +  + + +D  S R   ++      EAM       
Sbjct: 870  -------TISVKAVCDYRQIEITICKNDECVLED-NSQRTKWKVISPTGNEAMV------ 915

Query: 869  SCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS-------- 920
                        +V      P  D +E+     +++   +A+   L     S        
Sbjct: 916  -----------PSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLR 964

Query: 921  ---------SAEQLRQRYPGNSTQI----QRQQEELSQRWGQLEALKREKAVQLAHSVEV 967
                     + E+LR   PG   QI    Q   E+  Q             ++L   VE 
Sbjct: 965  KDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEA 1024

Query: 968  CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKV 1027
            C         + + + +   +++++    E+T   + +++ K + L R   + Q VV ++
Sbjct: 1025 C---------KARFQHL---MKSMENEDKEETVAKMYISELKNIRL-RLEEYEQRVVKRI 1071

Query: 1028 EEPGYAESQPLQGQVETLQ-GLLKQVQEQVAQ-RARRQAETQARQSFLQES--------- 1076
            +    + +     Q   L+    +  QE + Q R+   A +    SFL +S         
Sbjct: 1072 QSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTL 1131

Query: 1077 -QQLLLWAESVQAQLRSKEVSVD-VASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
              +L L  E +        V ++ + +   ++R  QD    +  ++ +L Q +     ++
Sbjct: 1132 RSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLS 1191

Query: 1135 ALDC---------PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDG 1184
            AL+           D ++  +   VL ++  + KV+ EQ  +   E  L+L+++  +  G
Sbjct: 1192 ALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY--QEKG 1249

Query: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHRE-FGRLLSTLGPRAEALRAHGEKLVQSQ 1243
                   H+    L+    ++     +L  +R   G L+  +    E   A  E +   Q
Sbjct: 1250 SQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWI----EETTAQQEMMKPGQ 1305

Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-----MQWMEEK 1298
               +  + EQL    +Q T L    E+ + +L    Q Q++ Q  + +     +Q M  K
Sbjct: 1306 AEDSRVLSEQL----SQQTALFAEIERNQTKL---DQCQKFSQQYSTIVKDYELQLMTYK 1358

Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELL-----------ATRRHVEALQQVGRELLSR 1347
              + + + S  +R   + L   +A   E +            T +HV+ +    R L   
Sbjct: 1359 AFVESQQKSPGKRR--RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEE 1416

Query: 1348 RPCGQEDIQTRLQGLRS--------------------------------KWEALNRKMTE 1375
                +E+ Q  ++ ++                                 + + L+ ++T 
Sbjct: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTT 1476

Query: 1376 RGDELQQAGQQEQLL----------RQLQDAKEQLEQLEGALQ-----SSETGQDLRSSQ 1420
            + +++ +A +  Q+           ++ +   EQL  L  A       S+   Q L+S  
Sbjct: 1477 KKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536

Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEE---TQKHLRRLELLQGHLAIR 1477
              Q   + L+ +  T   ++  L S   G A       +   TQ+ L  L+  Q  L  +
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWV-GQAERALAGHQGRTTQQDLSALQKNQSDL--K 1593

Query: 1478 GLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
             LQ         F  +      ++ E+    SP   T           +++ LQ E +  
Sbjct: 1594 DLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVA 1653

Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYF 1597
            Q +++  ++S           A+ + E  ++++     +     +  Q L      +Q  
Sbjct: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ-- 1711

Query: 1598 LDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN-------KHQAL----QEELAIYWSS 1646
                 L G   EK  L ++  Y     A  +L         +HQ L    Q  +    S+
Sbjct: 1712 -----LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 1766

Query: 1647 MEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELE--GTLR--LHEFLR 1702
               LDQ    LT    PE+Q+++Q++L E         A  + EL+   TL+  L +FL+
Sbjct: 1767 QAFLDQHGHNLT----PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ 1822

Query: 1703 EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESL 1762
            + ++ + WL   ++  +     G  PE    L  +   F   V      +    +  + +
Sbjct: 1823 DHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882

Query: 1763 LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKA 1822
            L               D++ ++ E  E ++  G+ ++D        +D  E  T +  K 
Sbjct: 1883 L---------------DMENSFKEGKEPSEI-GNLVKDK------LKDATERYTALHSKC 1920

Query: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR 1882
            T L +++   L        S   L+  +   E  +++LL          PG     V Q 
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASD---PG-----VLQE 1972

Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
            Q A T+    LQ  + + +  +E+ + +AR    +    +   R      V+E++     
Sbjct: 1973 QLATTKQ---LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHR-----HVQETTDS--- 2021

Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQT 2002
                LS  Q L   L  R  L Q+A    Q            VQE L +L     +V Q 
Sbjct: 2022 ---ILSHFQSLSYSLAERSSLLQKAIAQSQ-----------SVQESLESLLQSIGEVEQN 2067

Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS---------ALGSSVEEVEQ-- 2051
               KQ    +    Q  L    +L++ +A Q+ SL+ +            S+   V Q  
Sbjct: 2068 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2127

Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALH 2111
            L    + F ++   Q +KE++L+   K L +  + + L   LQ+ M  K           
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLK---KLLPQAEMFEHLSGKLQQFMENK----------- 2173

Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVM 2170
             S ++AS      Q +  I  + QQ++E  +   D ++ L  L             E ++
Sbjct: 2174 -SRMLAS----GNQPDQDITHFFQQIQELNLEMEDQQENLDTL-------------EHLV 2215

Query: 2171 TSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-EFLQRV 2229
            T ++  G AL    H        R+Q LRK + +L++ +  R ++    +  L EF + V
Sbjct: 2216 TELSSCGFALDLCQH------QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV 2269

Query: 2230 DLAEAWIQE-------KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSI 2282
               + W++E        E  M+  +L + +EH   L+  L ++   S G  V +   +  
Sbjct: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEH---LKSLLDDWA--SKGTLVEEINCKGT 2324

Query: 2283 SDLSLQLKNRDPEE---------------------------VKIICQRRSQLNNRWASFH 2315
            S  +L ++   P+                             +I C   S +N ++    
Sbjct: 2325 SLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD-MSDVNLKYEKLG 2383

Query: 2316 GNLLRYQQQLEGAL-EIHVLSRELDNVTKRIQEKEALIQALDCGKD---LESVQRLLRKH 2371
            G L   Q+ L+  L  +  + +E ++V + ++ KE +++++D        E+V+     +
Sbjct: 2384 GVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN 2443

Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSP--EAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
            +    E+     +++ ++  +  L    P  + A   +  Q+E+   W +       R+ 
Sbjct: 2444 KAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR 2503

Query: 2430 ALD--ALHQA--QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELD 2485
             L+  A H A  Q  ++ L+  L+  + +   +   P    P       ++ Q    E +
Sbjct: 2504 QLEESASHLACFQAAESQLRPWLMEKELMMGVL--GPLSIDPNMLNAQKQQVQFMLKEFE 2561

Query: 2486 SWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-------HQLQLQ 2538
            +            Q +LT     S    QV    ++EL S+   W E          Q+ 
Sbjct: 2562 ARRQQHEQLNEAAQGILTGPGDVSLSTSQV----QKELQSINQKWVELTDKLNSRSSQID 2617

Query: 2539 QAL----ELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQA 2594
            QA+    + Q  L  + +  R    +  S+ S     P A ++  L +   +  DLE   
Sbjct: 2618 QAIVKSTQYQELLQDLSEKVR-AVGQRLSVQSAISTQPEA-VKQQLEETSEIRSDLEQLD 2675

Query: 2595 GKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE-ELRQLQA 2651
             ++   +     L    G          R + + L  + L   A  R +RL+  L   Q 
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735

Query: 2652 FLQDSQEVAAWLREKNLVALEEGLLDTAM--LPAQLQKQQNFQAELDASMHQQQELQREG 2709
            F Q   E+  WL +K     +   +   +  L +QLQ+ + FQ  L+      + +  EG
Sbjct: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 2795

Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKACE-ALRLRRSMEELEN 2766
            + LL    P  E   +Q +L EL   W EL   +  + ++L+   + A + +  +E+L  
Sbjct: 2796 ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 2855

Query: 2767 WLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
            W+E  + ++    V      +   L   + +   V+K+    E L   A   +       
Sbjct: 2856 WIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 2915

Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA----DEEMAWVQEKL---- 2878
              + ++   + Q   ++ E LQ +  +LE  +  L+ F+++    ++++   + +L    
Sbjct: 2916 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD 2975

Query: 2879 PLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAAR 2938
             L +     ++L  +R  QE  Q LE ++      T+ ++        A     H+    
Sbjct: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL-LHQAEVA 3034

Query: 2939 VQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVL--------DSE 2990
             Q+  +    + +      ++  + +   QF   + E  S LA+    L        D++
Sbjct: 3035 QQEFLEVKQRVNSGCV---MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3091

Query: 2991 DMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE 3050
             +    E  +  L ++   K D+EA             +LE     +   +  +L+A+ +
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRH------MLEEEGTLDLLGLKRELEALNK 3145

Query: 3051 AHAELLRRAEARGHGLQEQLQLHQLERETL------LLDAWLTTKAATAESQDYGQDLEG 3104
               +L  R +AR    QEQL+L     E        L DA    + A A     G ++E 
Sbjct: 3146 QCGKLTERGKAR----QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201

Query: 3105 VKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPR--RYPHIQAQRSRIEAAWERL 3162
            +      F  F+KE     Q K+  +  L   L + A +      ++     I A W  L
Sbjct: 3202 INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTL 3261

Query: 3163 DQAIKARTENL-AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQ-QQHR 3220
            ++ +  R   L  A      FQ A   L   + +   L+  +    +   V   Q Q+ +
Sbjct: 3262 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3321

Query: 3221 RLERELEAMEKEVARLQTEACRLGQLHPAA-----PGGLAKVQEAWATLQAKAQERGQWL 3275
             L+R L+  +  V  LQ E  R+ Q    A      G L  ++  W  L +KA  R + L
Sbjct: 3322 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3381

Query: 3276 AQ----AAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
                  A Q H       + L+  +++  LA+SE +    A  +Q + +H+ L ++I   
Sbjct: 3382 EDILVLAKQFHETAEPISDFLSVTEKK--LANSEPVGTQTAKIQQQIIRHKALEEDIENH 3439

Query: 3332 RLQAQDLRQEGQQLVD-NSHFMSAEVTECLQELEGRLQELEE 3372
                    + GQ L    S      ++E +  L+ R  E+++
Sbjct: 3440 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481



 Score =  219 bits (557), Expect = 5e-56
 Identities = 479/2423 (19%), Positives = 963/2423 (39%), Gaps = 262/2423 (10%)

Query: 844  ESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKY- 901
            + L  LA  R  RL+ A+A    F     EL+ WL+ +     +  P +  LE +Q +  
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772

Query: 902  --ENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ--IQRQQEELSQRWGQLEALKREK 957
              E F  +L    G +  + +  E L    P    +  +Q Q  EL   W +L     ++
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832

Query: 958  AVQLA-----------HSVEVCSFLQECGPTQVQLRDVL--LQLEALQPGSSEDTCHALQ 1004
              +L            H  ++  ++++C     +LR  L  +QLE+    S       L 
Sbjct: 2833 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA----MLN 2888

Query: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
              +K+  +LE     L S    +     A+   ++ +   +   +  V E++      QA
Sbjct: 2889 EVEKRRSLLE----ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL------QA 2938

Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
            +T + +   Q  ++     ++++ ++   +  +++  A          LE++   QE LQ
Sbjct: 2939 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 2998

Query: 1125 QLDAQSQPMAAL------DCPDSQEVPNTLR---VLGQQGQELKVLWEQRQQWLQEGLE- 1174
             L+ Q   +         D PD  +    L    V  Q+  E+K         ++  LE 
Sbjct: 2999 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3058

Query: 1175 LQKFGREVDGFTATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
            + +F   V    +  A+    L  +  +G D     S ++  R F   +  L    EA  
Sbjct: 3059 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3118

Query: 1234 AHGEKLVQSQHPAAHT-VREQLQSIQAQWTRLQGRSEQRRRQL-------------LASL 1279
            A    +++ +       ++ +L+++  Q  +L  R + R+ QL             L  L
Sbjct: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3178

Query: 1280 QLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
                   + AE +QW+    +   ++        L   K  +  + + L  +  ++ +  
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQ-------LADFKMFQKEQVDPLQMK--LQQVNG 3229

Query: 1340 VGRELLSR--RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA--------GQQEQL 1389
            +G+ L+    + C  + ++  ++ + ++W  LN+K+ +R  +LQ+A           E L
Sbjct: 3230 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL 3289

Query: 1390 LRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHG 1449
            L  L D +E +   +     S   + +++  + QK  Q+L  + +     + A      G
Sbjct: 3290 LSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG----G 3342

Query: 1450 MAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQ----ASVELHQFCHLSNMEL 1498
              A  A L + +K   +LE L+          A R  QL+     + + H+     +  L
Sbjct: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402

Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
            S   + + +  P   T+     Q + R HK L+ +++ H   V + +  G+SL++   P 
Sbjct: 3403 SVTEKKLANSEPVG-TQTAKIQQQIIR-HKALEEDIENHATDVHQAVKIGQSLSSLTSPA 3460

Query: 1559 AQHIV-EQCQELEGHWAELERACEARAQCLQQAVTFQQYF-LDVSELEGW---VEEKRPL 1613
             Q ++ E+   L+  ++E++  C  +A  L QA++  + F  D  E+  W   VE+K   
Sbjct: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSS 3520

Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL 1673
            V  +D+ +D     R    H AL EE+     ++++  +  Q L      E+  ++QE+L
Sbjct: 3521 VFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578

Query: 1674 REQLRALQELAATRD---RELEGTLRLH-EFLREAEDLQGWL--ASQKQAAKGGES-LGE 1726
                    ++  T     R LE   +L  +F    E+L GWL    ++ A  GG+S  GE
Sbjct: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 3638

Query: 1727 DPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD----LQT 1782
                      +  +FQ + +   + V   RL+ +++ E   +   +V  R ++    L +
Sbjct: 3639 ----------QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 3688

Query: 1783 AWSELWEL-TQARGHALRDTETTLRVHRDL-------LEVLTQVQEKATSL-PNNVARDL 1833
              +E ++L +   G  + + +  ++  +         L  + + + K  +L P  + +D 
Sbjct: 3689 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQ 3748

Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
                AQL+  +    +++  +  + EL      +   C   Q   +Q++ +++ Q +  +
Sbjct: 3749 T--TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806

Query: 1894 QRRMEQRRAQLERARLLA-RFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
                 +R A+LERA++L  +F     + + W         +EE+    +  P     H+ 
Sbjct: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPW---------IEETRALIAQLPSPAIDHEQ 3857

Query: 1953 LRAELEAREKLWQQATQLGQQA--LLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERL 2010
            LR + E   +L +   +       LL  G   KE+  E   + +++ Q       K E +
Sbjct: 3858 LRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ-------KAENM 3910

Query: 2011 QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK-- 2068
             A+ +E++  R     E +  + +++     +   +E +E L  +  +   +    DK  
Sbjct: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970

Query: 2069 ------KEAALR-ERL----------------------KTLRRPRVRDRLPILLQRRMRV 2099
                  K A +  E+L                      K L    ++D+L  ++     +
Sbjct: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030

Query: 2100 KELAESRGHALHASLLMAS---FTQAA--TQAEDWIQAWAQQLKEP-VPPGDLRDKLKPL 2153
            K  AE R       L +A    +  AA  T  +D  Q     L+ P + P  ++ +++  
Sbjct: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-TQDIVHDLESPGIDPSIIKQQVEAA 4089

Query: 2154 LKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
               +  + E    HEE+        + + A       EV + +  +   WE+L +    R
Sbjct: 4090 ---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4146

Query: 2213 GQELEDRRNF-LEFLQRVDLAEAWIQEKEVKM-NVGDLGQDLEHCLQLRRRLREFRGNSA 2270
             ++LED     +++   +     W+    +K+  +  +G DL         ++EF+    
Sbjct: 4147 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206

Query: 2271 GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL- 2329
               +    +    +L L+ K  D  +  II +  ++L + W +    +   Q +LEGAL 
Sbjct: 4207 QQQIEMEKLNHQGELMLK-KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265

Query: 2330 EIHVLSRELDNVTKRIQEKEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
             +      L+ +   +   E L+ A      D + ++  L KH  L+ +V   QA VE++
Sbjct: 4266 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV 4325

Query: 2389 EREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAMLQE 2446
             +    L + S  + A  LR R + + + W  +  + ++R + L + L QAQ   + +++
Sbjct: 4326 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4385

Query: 2447 LLVSAQRLRAQMDTS-PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG 2505
             L+   R+ +Q+  S P    P  AR  L+ H E  ++L +  ++ +     G+ +L + 
Sbjct: 4386 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4445

Query: 2506 HPFSSDIR--QVLAGLEQELSSLEGAWQEHQLQLQQALELQL-FLSSVEKMERWLCSKED 2562
                S  +  Q +A LEQ+   +    +E + +L++AL L   F +S+++   WL   E 
Sbjct: 4446 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 4505

Query: 2563 SLASEGLWDP----LAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSA 2618
            SL    +  P    L  +   + +HK+   ++     +I  L+ T   L      +    
Sbjct: 4506 SL---NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL 4562

Query: 2619 LGRCQAMLL-RKEALFRQAGTRRHRLEELRQ-LQAFLQDSQEVAAWLR--EKNLVALEEG 2674
            +      +  R E + +++  R   L++ R+  + F +  +++  WL   E +L +  E 
Sbjct: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622

Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
              D   +  QL K + FQ  L           R G+ L +        + E  ++L    
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE-----KTLLPEDSQKLDNFL 4677

Query: 2735 GELQDNSQ----KKVAKLQKACEAL----RLRRSMEELENWLEPIEVELRA--PTVGQAL 2784
            GE++D       K V +  K  EAL    +   +++ L +WL  +E +L    P  G  L
Sbjct: 4678 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD-L 4736

Query: 2785 PGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLR 2844
              V  L+   +  +  + K+    + L    +  +         V+ Q + L  R+ ++ 
Sbjct: 4737 DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 4796

Query: 2845 EPLQERRTALEARSLLLKFFRDADEEMA-WVQE-KLPLAAAQDYGQSLSAVRHLQEQHQN 2902
            +    +++ LE      + FRD    +  W+ E +  L           A++ L + H+ 
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKE 4856

Query: 2903 LESEMSSHEALTRVVLGTGYKLVQAGH-----FAAHEVAARVQQLEKAMAHLRAEAARRR 2957
               ++          +  G  ++   H        H +     + E+ +   +    R  
Sbjct: 4857 FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLE 4916

Query: 2958 LLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              L +     + L ELL    W        D E +  + +  +AL+   +    ++    
Sbjct: 4917 TALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQ 4976

Query: 3018 PRIERLQQTAALLESRKNPE---SPKVLAQLQAVREAHAE-------LLRRAEARGHGLQ 3067
            P ++R+ +T      RKN E   +P +       R++ ++       +L ++EA+   + 
Sbjct: 4977 PDVDRVTKT----YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRIN 5032

Query: 3068 ------EQLQLHQLERETLLLDA 3084
                  +Q+ L  LER+  L DA
Sbjct: 5033 QLSARWQQVWLLALERQRKLNDA 5055



 Score =  209 bits (533), Expect = 3e-53
 Identities = 673/3423 (19%), Positives = 1315/3423 (38%), Gaps = 451/3423 (13%)

Query: 250  HQGQTVQRRLTKILLQLQETELLQ-------TQYEQLVADLLRWIAEKQMQLEARDFPDS 302
            HQG+T Q+ L+ +     + + LQ       T +  +V D+  ++ E Q +L  R+    
Sbjct: 1573 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE---- 1628

Query: 303  LPAMRQLL-AAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
            L A+R+ L  A   +   ++  R+ Q+   EA+   LQ   +       L      +  L
Sbjct: 1629 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 1688

Query: 362  SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
                  L+W  +  S    Q L  L  +E L+     K AL  +   D    ++QA   P
Sbjct: 1689 ------LDWVTSVGSSG-GQLLTNLPGMEQLSGASLEKGALDTT---DGYMGVNQA---P 1735

Query: 422  ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQEEV 476
              L   +   + +      +L Q+  F    + A     +  H+        + ++  E+
Sbjct: 1736 EKL---DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGEL 1792

Query: 477  TVRWQRLLQHLQGQRKQVADMQAVLS-LLQEVEAASHQLEELQEPARSTACGQQLAEVV- 534
              ++   L   + + KQV  +Q  L   LQ+ +     LE  ++   +   G    E + 
Sbjct: 1793 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLP 1852

Query: 535  ELLQRHDLLEAQVSAHGAHVSHLA---QQTAELDSSLGTSVE------VLQAKARTLAQL 585
             LL+R       V +H   +  +    Q+  ++++S     E      +++ K +   + 
Sbjct: 1853 SLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATER 1912

Query: 586  QQSLVALVRARRALLEQTL-QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
              +L +      + L   L Q  +F  + +  +AW++ C   V    L   ++   G LQ
Sbjct: 1913 YTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQ 1971

Query: 645  KH----KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
            +     K L+ E+  HQ     L +  RD+        PD     E              
Sbjct: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS---------- 2021

Query: 701  GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
                       +L +F    ++ S+    RSSL + +  Q Q+  E+       LE +L+
Sbjct: 2022 -----------ILSHF----QSLSYSLAERSSLLQKAIAQSQSVQES-------LESLLQ 2059

Query: 761  AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
            +     + LE  G+  S+ +S   +  AL+     L+      ++S         +M   
Sbjct: 2060 SIGEVEQNLE--GKQVSSLSS-GVIQEALAT-NMKLKQDIARQKSSLEA----TREMVTR 2111

Query: 821  AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMA---LFGFCSSCGELQLW 876
                 D     +LQ +   +SQ +E L    Q + + L++ +    +F   S  G+LQ +
Sbjct: 2112 FMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS--GKLQQF 2169

Query: 877  LE-KQTVLLQRVQPQADT------LEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRY 929
            +E K  +L    QP  D       ++ + L+ E+    L   + L  E+SS    L    
Sbjct: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---- 2225

Query: 930  PGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVE--------VCSFLQECGPTQVQL 981
              +  Q Q + + L + + +L+   +E+    +   E        V +F +    T+  +
Sbjct: 2226 --DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2283

Query: 982  RDVLLQLEALQPGSSEDTCHAL--QLAQKKTLVLERRVH--FLQSVVVKVEEP------- 1030
                  + A +     +   +L    A K TLV E       L+++++++  P       
Sbjct: 2284 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343

Query: 1031 --------------GYAESQPLQG----------QVETLQGLLKQVQEQVAQRARRQAET 1066
                          GY   + L            + E L G+L + QE +     R  E 
Sbjct: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403

Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL 1126
                   +E+  +L W ES +  L+S +        + +  + +     +   ++   ++
Sbjct: 2404 H------KEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457

Query: 1127 DAQSQPMAAL--DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ-WLQEGLELQKFGREVD 1183
                + +A L    P+SQE  N  ++     +EL   WE+  +  +    +L++    + 
Sbjct: 2458 QKVKEALAGLLVTYPNSQEAENWKKIQ----EELNSRWERATEVTVARQRQLEESASHLA 2513

Query: 1184 GFTATCANHQAWLHLDNLGEDVREALS-----LLQQHREFGRLLSTLGPRAEALRAHGEK 1238
             F A  +  + WL    L   V   LS     L  Q ++   +L       EA R   E+
Sbjct: 2514 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF----EARRQQHEQ 2569

Query: 1239 LVQSQHP----------AAHTVREQLQSIQAQWT----RLQGRSEQRRRQLLASLQLQEW 1284
            L ++             +   V+++LQSI  +W     +L  RS Q  + ++ S Q QE 
Sbjct: 2570 LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 2629

Query: 1285 KQDVAELMQWMEEKGLMAAH---EPSGARRNILQTLK--------RHEAAESELLATRRH 1333
             QD++E ++ + ++  + +    +P   ++ + +T +         HE  E++ L     
Sbjct: 2630 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 2689

Query: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRS-KWEALNRKMTERGDELQQAGQQEQLLRQ 1392
            V   +Q  ++ L +R    E +   LQGL     + +NR         Q     ++L   
Sbjct: 2690 VLIGEQYLKDELKKR---LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 2746

Query: 1393 LQDAKEQ----------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
            L D + Q          LE+L+  LQ +E  Q  +S  +    ++ + +E  +L      
Sbjct: 2747 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQ--KSLNQHSGSYEVIVAEGESL------ 2798

Query: 1443 LASMAHGMAASPAI--LEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
            L S+  G         L E + H   L         R        + +Q+ H+ ++ + W
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW-HVEDL-VPW 2856

Query: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
            + +     S    T      +S   + K +  EV+  +  ++ + S+   L  S      
Sbjct: 2857 IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916

Query: 1561 HIVEQC----QELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
             I ++     Q ++    EL+    +  +  Q+   FQ+ F ++   E  VE  +  +  
Sbjct: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEI 2973

Query: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRV 1668
             D    +A + + + K +A QE L      ++ L    Q L           ++  Q  V
Sbjct: 2974 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3033

Query: 1669 VQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDP 1728
             Q+   E  + +       + +LEG  + H  +RE   +   LA       G  ++G D 
Sbjct: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGAIGRDT 3090

Query: 1729 EHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD-LQTAWSEL 1787
            +           F +++ +    + A       +LE   +   +  +R+ + L     +L
Sbjct: 3091 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150

Query: 1788 WELTQARGHALRDTETTLRVHRDLLEVL------TQVQEKATSLPNNVARDLCGLEAQLR 1841
             E  +AR   L   E TL    D    L      T   E+A +L   V  ++  +  QL 
Sbjct: 3151 TERGKARQEQL---ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207

Query: 1842 SHQGLERELVGT-ERQLQELLETA-GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQ 1899
              +  ++E V   + +LQ++     G +Q          ++   + +   W  L +++ Q
Sbjct: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267

Query: 1900 RRAQLERARL-LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELE 1958
            R AQL+ A L   +F+ A+    SW A    D +   ++Q+P S   K+   Q    +L 
Sbjct: 3268 RIAQLQEALLHCGKFQDALEPLLSWLA----DTEELIANQKPPSAEYKVVKAQIQEQKLL 3323

Query: 1959 AR---------EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
             R         + L  +  ++ Q A LA     +++  +L +L+ +  ++    A +Q++
Sbjct: 3324 QRLLDDRKATVDMLQAEGGRIAQSAELA---DREKITGQLESLESRWTELLSKAAARQKQ 3380

Query: 2010 LQ-----AEQQEQLFLRECGRLEEILAAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVL 2063
            L+     A+Q    F      + + L+  E  L  S  +G+   +++Q I +H+   + +
Sbjct: 3381 LEDILVLAKQ----FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436

Query: 2064 T--AQDKKEAA-LRERLKTLRRPR----VRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
               A D  +A  + + L +L  P     + +++  L  R   +++    +     A+LL 
Sbjct: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRK-----AALLD 3491

Query: 2117 ASFTQAATQAEDWIQA--WAQQLKEPVPPGDLRDKLKPLLK-----HQAFEAEVQAHEEV 2169
             + + A    ED ++   W  ++++ +    ++D  + +L      H A   E+   ++ 
Sbjct: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551

Query: 2170 MTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-E 2224
            +    K G+ALL Q+    GE    + ++L G++  + D+    +   + LE  R    +
Sbjct: 3552 VDQAIKNGQALLKQT---TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608

Query: 2225 FLQRVDLAEAWIQEKEVKMNV-GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
            F    +    W++E E ++   G      E   Q ++R +E +       +    +  +S
Sbjct: 3609 FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVS 3668

Query: 2284 DLSLQLKNRDPEEV--KIICQRRSQ-------LNNRWASFHGNLLRYQQQLEGA------ 2328
               L+L      E   K++     Q       +  R       + R QQ  + A      
Sbjct: 3669 RALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 3728

Query: 2329 --------LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL-----E 2375
                    + +  +  E D  T ++Q ++A   ++D  +  +S+  L     E+     E
Sbjct: 3729 VAETKRKLMALGPIRLEQDQTTAQLQVQKAF--SIDIIRHKDSMDELFSHRSEIFGTCGE 3786

Query: 2376 REVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
             +   +Q + ESL ++   +   + E    L   Q  V + W       +   E    + 
Sbjct: 3787 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW-------ETYEELSPWIE 3839

Query: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLAR 2495
            + + L A L    +  ++LR Q +         E R++ E   E K  +D          
Sbjct: 3840 ETRALIAQLPSPAIDHEQLRQQQE---------EMRQLRESIAEHKPHIDKLL------- 3883

Query: 2496 STGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMER 2555
              G QL          + +     E   + ++   ++  L L +A+     ++       
Sbjct: 3884 KIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 3943

Query: 2556 WLCSKEDSLASEGLWDPLAPME-----PLLWKHKMLEWDLEVQAGKISALEATAR---GL 2607
             +    ++L+S     PL P E       +  +K    +LE       AL+       G 
Sbjct: 3944 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGR 4003

Query: 2608 HQGGHPE--AQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLR 2664
             QG   +  A+    +   M+   E +  +A  R  + L+ L   + F  D   +   ++
Sbjct: 4004 SQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK 4063

Query: 2665 EKNLVA--LEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQR--EGQRLLQGGHPAS 2720
            +   +   LE   +D +++  Q++  +  + E D  +H++ E  R      +   G    
Sbjct: 4064 DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDG-LHEELEFIRILGADLIFACGETEK 4122

Query: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEA-LRLRRSMEELENWLEPIEVEL-RAP 2778
              +++ ++E+   W  L    ++++ KL+ A +A ++ + +++ + +WL+   ++L   P
Sbjct: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182

Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG--HCLAQDVEEQARRL 2836
             VG  L  V + L   +E +  V ++  + E L  Q +  +++         + E    L
Sbjct: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242

Query: 2837 LQRFKSLREPLQERRTALEARSLLLKFFRDADEE-MAWVQEKLPLAAAQDYGQSLSAVRH 2895
               +++L E +  R+  LE   L L  F+ A EE M+W+     L  AQ        V  
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302

Query: 2896 LQ-EQHQNLESEMSSHEALTRVVLGTGYKLVQ--AGHFAAH---EVAARVQQLEKAMAHL 2949
            ++  +H  L++++ +H+A    V   G +L++  AG  A+     + A  Q  E  +   
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362

Query: 2950 RAEAARRRLLLQQAQ----EAQQFLTELLEAGSWLAERG---------------HVLDSE 2990
                 + +  LQQAQ    E + FL EL    S L+                  H+    
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422

Query: 2991 DMGHSAEATQALLR--RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV 3048
             +    E    LL   RL    RD      + E   Q+ ALLE + +  S K+  +   +
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKL 4479

Query: 3049 REAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVL 3108
             EA    L  A    + LQE +    L  ++L + +  +    T  SQ     +E  KV 
Sbjct: 4480 EEA----LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ-----IEEHKVF 4530

Query: 3109 EEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKA 3168
              + +A R ++  L Q     L+ L+   +         I+     +++ WE++ Q    
Sbjct: 4531 ANEVNAHRDQIIELDQTG-NQLKFLSQKQD------VVLIKNLLVSVQSRWEKVVQRSIE 4583

Query: 3169 RTENLAAAHE-VHSFQQAAAELQGRMQEKTALMKGE-DGGHSLSSVRTLQQQHRRLEREL 3226
            R  +L  A +    F +A  +L   +++  + +  E +  +    ++    +H+  ++ L
Sbjct: 4584 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 4643

Query: 3227 EAMEK------EVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ 3280
               +          R   E   L +        L +V++ W T+  K+ ER   L +A  
Sbjct: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703

Query: 3281 -GHAFLGRCQELLAWAQERQ-ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDL 3338
                F+   Q L+ W  + + +LA  + +  D+     L+  H+   +E+ +     Q L
Sbjct: 4704 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 4763

Query: 3339 RQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ-KLRQRLEQA 3397
            ++ G++L++NS   +  V       +G+LQEL   W      C  S   Q +L Q L+QA
Sbjct: 4764 KRSGRELIENSRDDTTWV-------KGQLQELSTRWD---TVCKLSVSKQSRLEQALKQA 4813

Query: 3398 EAW 3400
            E +
Sbjct: 4814 EVF 4816



 Score =  162 bits (411), Expect = 4e-39
 Identities = 677/3488 (19%), Positives = 1318/3488 (37%), Gaps = 421/3488 (12%)

Query: 272  LQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLA-AFTIFR-TQEKPPR----- 324
            L TQ+ + ++D LR + E++  +E  +  + +  +++LL    T+ R TQ K        
Sbjct: 1398 LTTQHVKYISDALRRLEEEEKVVE-EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKE 1456

Query: 325  --------LQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAE------------LSQ 363
                    L+Q+  +E L  + +   +A +  + FL   G  L+E            L++
Sbjct: 1457 STDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNK 1516

Query: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRE---SFLKDAEQVL--DQAR 418
             +  L    A + Q LQ +L      +TL ++        E   S++  AE+ L   Q R
Sbjct: 1517 AYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGR 1576

Query: 419  APPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQ 473
                 L+ ++     L  L+  I  +   F  + +  +   +E     +      +  + 
Sbjct: 1577 TTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKL 1636

Query: 474  EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARS--------TA 525
             +   +++ L +  +  +K++ +  AV S LQ+    S   +EL E  +         T+
Sbjct: 1637 HQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 1694

Query: 526  CGQQLAEVVELLQRHDLLEAQVSAHGA-HVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
             G    +++  L   + L       GA   +       +    L    E+++A+ + L  
Sbjct: 1695 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS 1754

Query: 585  LQQSLVALVRARRALLEQ-----TLQRAEFLRNC--EEEEAWLKECGQRVGNAALGRDLS 637
             QQ+ +   ++ +A L+Q     T +  + L+    E +E +     Q        + L 
Sbjct: 1755 QQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814

Query: 638  -QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQ 696
             ++   LQ HK  E+ + R +    ++ + G       P T P   +R    QG +    
Sbjct: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSS-----PETLPSLLKR----QGSFS--- 1862

Query: 697  TRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQA--AAETLLRRHVR 754
              V+     L+   +  Q   D   +    +E +   E  +  +D+   A E     H +
Sbjct: 1863 EDVISHKGDLRFVTISGQKVLDMENS---FKEGKEPSEIGNLVKDKLKDATERYTALHSK 1919

Query: 755  LERV----------LRAFAAELRRLEEQGRAASARASLFTVNSALSPPG---ESLRNPGP 801
              R+             F      L+   +A  A       ++  S PG   E L     
Sbjct: 1920 CTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979

Query: 802  WSEASC-HPGPGDAWK------MALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRR 854
              E    H  P +  +      M +  EP PD     + +T D +   ++SL      R 
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERS 2037

Query: 855  ARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGL 914
            + L++A+A          +Q  LE     +  V+   +  +V  L       ALA    L
Sbjct: 2038 SLLQKAIA------QSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091

Query: 915  WAEVS---SSAEQLRQRYP-----GNSTQ---IQRQQEELSQRWGQLEALKREKAVQLAH 963
              +++   SS E  R+         +ST    +Q +  E+SQR+ QL   ++EK   L  
Sbjct: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151

Query: 964  SVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE---RRVHFL 1020
             +      +       Q  +   ++ A      +D  H  Q  Q+  L +E     +  L
Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211

Query: 1021 QSVVVKVEEPGYA-ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQ 1078
            + +V ++   G+A +    Q +V+ L+    ++Q+ V +R +  +  Q +   F +  + 
Sbjct: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271

Query: 1079 LLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL-- 1136
               W +  +  +   E S+     ++ +   + LL++       +++++ +   +  L  
Sbjct: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331

Query: 1137 --DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQA 1194
                PDSQ    T  +L   G  +  +          G    K   E+      C     
Sbjct: 2332 EITAPDSQG--KTGSILPSVGSSVGSV---------NGYHTCKDLTEIQ-----CDMSDV 2375

Query: 1195 WLHLDNLGEDVREALSLLQQ--------HREFGRLLSTLGPRAEALRAHGEKLVQSQHPA 1246
             L  + LG  + E    LQ         H+E   +L  L  + E L++       S    
Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMD---AMSSPTK 2432

Query: 1247 AHTVREQLQSIQAQWTRLQGRSE--QRRRQLLASL--------QLQEWKQDVAELMQWME 1296
              TV+ Q +S +A    L+  S   Q+ ++ LA L        + + WK+   EL    E
Sbjct: 2433 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2492

Query: 1297 EKGLMAAHEPSGARRNILQTLKRH----EAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
                  A E + AR+  L+    H    +AAES+L       E +  V            
Sbjct: 2493 R-----ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGV------------ 2535

Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
                  L  L      LN           Q  Q + +L++ +  ++Q EQL  A Q   T
Sbjct: 2536 ------LGPLSIDPNMLNA----------QKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579

Query: 1413 GQD--LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
            G      S+ ++QK  Q +  +   L  K+ + +S         AI++ TQ      ELL
Sbjct: 2580 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQI-----DQAIVKSTQYQ----ELL 2630

Query: 1471 QGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKEL 1530
            Q              +L +        LS   +      P +  + L     +    ++L
Sbjct: 2631 Q--------------DLSEKVRAVGQRLS--VQSAISTQPEAVKQQLEETSEIRSDLEQL 2674

Query: 1531 QVEVKAHQGQVQR--VLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQ 1588
              EVK  Q       VL   + L      + + +    Q LE   A+     +A     Q
Sbjct: 2675 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734

Query: 1589 QAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRL-INKHQALQEELAIYWSSM 1647
            Q   FQQ F    EL  W+++K+   +       +   L+  + +++  Q+ L  +  S 
Sbjct: 2735 Q---FQQMF---DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788

Query: 1648 EELDQTAQTLTGPEVP-EQQRVVQERLREQLRALQELA---ATRDRELEGTL-RLHEFLR 1702
            E +    ++L     P E++R +Q +L E     +EL+   A R   L+  + +  ++  
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848

Query: 1703 EAEDLQGWLASQKQAAKGGE-SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAES 1761
              EDL  W+   K  AK  E  +  DP        +     ++VE     +      A+ 
Sbjct: 2849 HVEDLVPWIEDCK--AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906

Query: 1762 LLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK 1821
            L+    +    +R  +  +      + E  QA+  +L +    LR   +  E    +++K
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR---EFQESFKNIEKK 2963

Query: 1822 ATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE---------TAGRVQKLCP 1872
                 + +      L +Q  S++ LE+  +  ++++ + LE         T G V+    
Sbjct: 2964 VEGAKHQL-EIFDALGSQACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD 3020

Query: 1873 GPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDL 1931
            G  A  +  + +   Q +  +++R+      +E +   + +F   VR+  S  A +  +L
Sbjct: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080

Query: 1932 Q--------VEESSQEPSSGPLKLSAHQWLRAELEARE-KLWQQATQLGQQALLAAGTPT 1982
                      +    +     L L+    L+ ++EA E +      + G   LL      
Sbjct: 3081 DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLG----- 3135

Query: 1983 KEVQEELRALQDQRDQVYQTWARKQERLQAE--QQEQLFLRECGRLEEILAAQEVSLKTS 2040
              ++ EL AL  Q  ++ +    +QE+L+    + E  + +  G  +   AA+E      
Sbjct: 3136 --LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193

Query: 2041 ALGSSVEEVEQLIRKHEVF---------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPI 2091
             +G+ VE + Q +   ++F         +K+       +  ++   K      +   +  
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253

Query: 2092 LLQRRMRV-KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
            +  R   + K++A+       A L    F  A      W+    + +    PP      +
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313

Query: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAG--EVSQRLQGLRKHWEDLRQA 2208
            K  ++ Q     +    +    + +     +AQS   A   +++ +L+ L   W +L   
Sbjct: 3314 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3373

Query: 2209 MALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMN----VGDLGQDLEHCLQLRRRLR 2263
             A R ++LED      +F +  +    ++   E K+     VG     ++  +   + L 
Sbjct: 3374 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE 3433

Query: 2264 EFRGNSAGDTVGDACI-RSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
            E   N A D      I +S+S L+       P E  ++ ++   L  R++       R  
Sbjct: 3434 EDIENHATDVHQAVKIGQSLSSLT------SPAEQGVLSEKIDSLQARYSEIQDRCCRKA 3487

Query: 2323 QQLEGALEIHVLSRELD----NVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREV 2378
              L+ AL    L  E +    N    +++K + +   D  +D+  + R    H  L  E+
Sbjct: 3488 ALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV--LHRQHADHLALNEEI 3545

Query: 2379 HPIQAQVE-SLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ- 2436
               +  V+ +++     L Q + E    ++ +   +   +  +   + K    L+   Q 
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605

Query: 2437 AQKLQAMLQELLVSAQRLRAQMDTSPA--------PRSPVEARRMLEEHQECKAELDSWT 2488
            A K Q+  +EL    + +  ++ TS          P+     + + +E  E +  LD+  
Sbjct: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 3665

Query: 2489 D-SISLARSTGQQLLTAGHPFSSDIRQ----VLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
            + S +L      +         SD  +    V   + Q +  ++ A Q  Q Q +QA + 
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ-QYEQAADA 3724

Query: 2544 QLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAG-------- 2595
            +L          W+   +  L + G         P+  +       L+VQ          
Sbjct: 3725 EL---------AWVAETKRKLMALG---------PIRLEQDQTTAQLQVQKAFSIDIIRH 3766

Query: 2596 KISALEATA-RGLHQGGHPEAQSAL--GRCQAMLLRKEALFRQAGTRRHRLEELRQL-QA 2651
            K S  E  + R    G   E Q  +   + ++++ + EA+      R  RLE  + L   
Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826

Query: 2652 FLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ----ELQR 2707
            F +  +E++ W+ E    AL   L   A+   QL++QQ    +L  S+ + +    +L +
Sbjct: 3827 FWETYEELSPWIEETR--ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLK 3884

Query: 2708 EGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELEN 2766
             G +L +      E ++E+ ++   ++ ++++  +++   L +A  ++ ++    +++E 
Sbjct: 3885 IGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 3944

Query: 2767 WLEPIE---VELRAPTVGQA-LPGVGELLGTQR-------ELEAAVDKKARQAEALLGQA 2815
             LE +E     LR P +  A +  + E +   +       +L+ + +   R+ E L+G++
Sbjct: 3945 MLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRS 4004

Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA-LEARSLLLKFFRDADEEMAWV 2874
            Q   ++    A++++++  +++  ++ ++   +ER    L+   L  KF+ D    +  +
Sbjct: 4005 QGADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4062

Query: 2875 QEKLPLAA-AQDYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFAA 2932
            ++   +    +  G   S ++   E  + ++ E    HE L  + +     +   G    
Sbjct: 4063 KDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4122

Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQA-QEAQQFLTELLEAGSWLAERGHVLDS-E 2990
             EV   + ++  A  +L      R   L+ A Q A Q+   L     WL      L +  
Sbjct: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182

Query: 2991 DMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQ--LQAV 3048
             +G      +  L  ++  K ++      +E+L     L+  +   E+ + + +  L  +
Sbjct: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242

Query: 3049 REAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQ-DYGQDLEGVK 3106
            +     L  +   R H L+  L  L Q +     L +WLT      ++Q     D + ++
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302

Query: 3107 VLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA---AWERLD 3163
            V   K    + +V +  QA V  + K    L   +        + RSR+EA    WE + 
Sbjct: 4303 VELAKHHVLKNDVLA-HQATVETVNKAGNELLESSAG--DDASSLRSRLEAMNQCWESVL 4359

Query: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTA----LMKGEDGGHSLSSVRTLQQQH 3219
            Q  + R + L +   +   Q   +E++  + E T     L   +  G    + R     H
Sbjct: 4360 QKTEEREQQLQST--LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417

Query: 3220 RRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEA-------WATLQAKAQERG 3272
              L  +L+A E+   +L  +  RL  L     G  +K +++       W  + +K +ER 
Sbjct: 4418 MELYSQLKAKEETYNQLLDKG-RLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476

Query: 3273 QWLAQAAQ-GHAFLGRCQELLAW---AQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
              L +A      F    QE + W   A++   +AS   L  +   ++  + +H+    E+
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ--IEEHKVFANEV 4534

Query: 3329 RECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
               R Q  +L Q G QL     F+S +    L  ++  L  ++  W    QR  E    +
Sbjct: 4535 NAHRDQIIELDQTGNQL----KFLSQKQDVVL--IKNLLVSVQSRWEKVVQRSIERG--R 4586

Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTE 3448
             L    ++A+ +   W+ L+   +   S  D EL +    D  KL  ++ ++F   QKT 
Sbjct: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEF---QKTL 4643

Query: 3449 MEQELLLQPQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTPTMEGSLEFK 3508
              +    QP      R G +L      P   Q L   L E RD  D     ++E   + +
Sbjct: 4644 GGK----QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699

Query: 3509 QHLLPGGR 3516
            + LL  G+
Sbjct: 4700 EALLFSGQ 4707



 Score =  158 bits (399), Expect = 1e-37
 Identities = 338/1660 (20%), Positives = 649/1660 (39%), Gaps = 190/1660 (11%)

Query: 254  TVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAF 313
            T+ +++ + + QLQE  L   +++  +  LL W+A+ + +L A   P S        A +
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPPS--------AEY 3310

Query: 314  TIFRTQEKPPRLQQRGAAEALLFRLQTA--LQAQNRRPFLPHEGLGLAELSQCWAGLE-- 369
             + + Q +  +L QR     L  R  T   LQA+  R     E   LA+  +    LE  
Sbjct: 3311 KVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAE---LADREKITGQLESL 3363

Query: 370  ---WAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
               W E     A +Q+  QL+ +  LA++F   A     FL   E+ L  +       A 
Sbjct: 3364 ESRWTELLSKAAARQK--QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3421

Query: 427  VEAAVQRLGMLEAGI------LPQEGRF-QALAEIADILRQEQYHSWAD-VARRQEEVTV 478
            ++  + R   LE  I      + Q  +  Q+L+ +     Q       D +  R  E+  
Sbjct: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481

Query: 479  RWQR----LLQHLQGQRKQVADMQAVLSLLQEVE--AASHQLEELQEPARSTACGQQLAE 532
            R  R    L Q L   R    D   VL+ L EVE   +S  +++ ++          LA 
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541

Query: 533  VVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVAL 592
              E++ R   ++  +              A L  + G  V ++Q K   +      +   
Sbjct: 3542 NEEIVNRKKNVDQAIK----------NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591

Query: 593  VRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV----GNAALGRDLSQIAGALQKHK 647
                   LEQ  Q A +F    EE   WL+E  + +    G +  G  + Q     Q+ K
Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ---QRQK 3648

Query: 648  ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG--ERAEAVQGGWQLLQTRVVGRGAR 705
             L+ EV  H+ V +D V           P +   G  +        ++L+   +  R   
Sbjct: 3649 ELKKEVMEHRLV-LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707

Query: 706  LQTALLVLQYFADAAEA-ASWLRERRSSLERAS---CGQDQAAAETLLRRHVRLERVLRA 761
            +  A+   Q +  AA+A  +W+ E +  L         QDQ  A+          +V +A
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL---------QVQKA 3758

Query: 762  FAAE-LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
            F+ + +R  +      S R+ +F                G   E                
Sbjct: 3759 FSIDIIRHKDSMDELFSHRSEIF----------------GTCGE---------------- 3786

Query: 821  AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLE 878
                   +  T+LQ + + L Q YE++  L   R ARLE A  L   F  +  EL  W+E
Sbjct: 3787 -------EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839

Query: 879  KQTVLLQRVQPQA---DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ 935
            +   L+ ++   A   + L   Q +      ++A  K    ++     QL++  P     
Sbjct: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899

Query: 936  IQRQQEELSQRWGQLEALKREKAVQL----AHSVEVCSFLQECGPTQVQLRDV--LLQLE 989
            ++ + ++    + Q++   R++A+ L    + S ++  F  +  P    L ++   L++ 
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959

Query: 990  ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEE-PGYAESQPLQGQVETLQGL 1048
             L P   +     +   +  T+ LE+     +++  + EE  G ++        + +Q  
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019

Query: 1049 LKQV---QEQVAQRARRQA-----ETQARQSFLQESQQLLLWAESVQAQLRSKE------ 1094
            L Q+    E +  RA  +        +  + F  +   LL   +  Q  +   E      
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079

Query: 1095 --VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLG 1152
              +   V +A+ +  E   L EE+    E ++ L A    + A    +  EV  ++  + 
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEEL----EFIRILGADL--IFACGETEKPEVRKSIDEMN 4133

Query: 1153 QQGQELKVLWEQRQQWLQEGLE--------LQKFGREVDGFTATCANHQAWLHLDNLGED 1204
               + L   W++R + L++ ++        LQ     +D              +  +G D
Sbjct: 4134 NAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT------MPPVGTD 4187

Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWT 1262
            +      L + +EF   +       E L   GE +++  +       +RE L  ++  W 
Sbjct: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247

Query: 1263 RLQGRSEQRRRQLL-ASLQLQEWKQDVAELMQWM-EEKGLMAAHEP-SGARRNILQTLKR 1319
             L  +   R+ +L  A L L +++  + ELM W+   + L+ A  P SG  + I   L +
Sbjct: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307

Query: 1320 HEAAESELLATRRHVEALQQVGRELL-SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
            H   ++++LA +  VE + + G ELL S        +++RL+ +   WE++ +K  ER  
Sbjct: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367

Query: 1379 ELQQAGQQEQ-LLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQ-----KRHQQLESE 1432
            +LQ   QQ Q    +++D   +L ++E  L +S+    L  + R Q     + + QL+++
Sbjct: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427

Query: 1433 SRTLAAKM--AALASMAHGMAASPAILEETQKHL-RRLELLQGHLAIRGLQLQASVEL-H 1488
              T    +    L  ++   + S +  E++   L ++  ++   +  R  +L+ ++ L  
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487

Query: 1489 QFCHLSNMELSWVA---EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
            +F +     ++W+    + +   SP S    LN   S   +HK    EV AH+ Q+  + 
Sbjct: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545

Query: 1546 SSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SEL 1603
             +G  L      Q   +++     ++  W ++ +    R + L  A    + F +   +L
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605

Query: 1604 EGWVEE-KRPLVSSRDYGRDEAATLRLINKHQALQEELA----IYWSSMEELDQTAQTLT 1658
              W+E+ +  L S  +   D       ++KH+  Q+ L     +Y +++       +   
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 4665

Query: 1659 GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717
             PE  ++       +R++   +   +  R  +LE  L    +F+   + L  WL   +  
Sbjct: 4666 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 4725

Query: 1718 AKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQ 1777
                + +  D +  ++L      FQ ++   +  V   +     L+E        V+ + 
Sbjct: 4726 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785

Query: 1778 QDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
            Q+L T W  + +L+ ++   L        V RD + +L +
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825



 Score =  157 bits (396), Expect = 2e-37
 Identities = 402/1996 (20%), Positives = 771/1996 (38%), Gaps = 224/1996 (11%)

Query: 281  ADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPP---RLQQ-RGAAEALLF 336
            A+ L+W+   ++++           + Q LA F +F+ ++  P   +LQQ  G  + L+ 
Sbjct: 3188 AEALQWVVGTEVEI-----------INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3236

Query: 337  RLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRF 396
                    Q     L H+   + E++  W  L       ++ + QR+ QLQ       +F
Sbjct: 3237 SAGKDCDVQG----LEHD---MEEINARWNTL-------NKKVAQRIAQLQEALLHCGKF 3282

Query: 397  QHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQAL-AEIA 455
            Q       S+L D E+++   + P A    V+A +Q   +L+  +  ++     L AE  
Sbjct: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGG 3342

Query: 456  DILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLE 515
             I +  +      +  + E +  RW  LL     ++KQ+ D+  +     E         
Sbjct: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402

Query: 516  ELQEP--ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
             + E   A S   G Q A++ + + RH  LE  +  H   V H A +  +  SSL +  E
Sbjct: 3403 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV-HQAVKIGQSLSSLTSPAE 3461

Query: 574  --VLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNA 630
              VL  K  +L      +      + ALL+Q L  A      E E   WL E   ++ + 
Sbjct: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 3521

Query: 631  ALGRDLSQIAGALQK--HKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAV 688
             + +D  Q     Q   H AL  E+   +      ++ G+ L       +   GE    +
Sbjct: 3522 FV-KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL------LKQTTGEEVLLI 3574

Query: 689  QGGWQLLQTRVVGRGARLQTALLVLQYFADAA--------EAASWLRERRSSLERASCGQ 740
            Q     ++TR          AL  L+     A        E   WLRE    L  A+ G 
Sbjct: 3575 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL--ATSGG 3632

Query: 741  DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
                 E + +              + R+ E +      R  L TVN        +L    
Sbjct: 3633 QSPTGEQIPQ-------------FQQRQKELKKEVMEHRLVLDTVNEV----SRALLELV 3675

Query: 801  PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
            PW             K+   A        +TI Q  D +    +  +   Q   A L   
Sbjct: 3676 PWRARE------GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729

Query: 861  MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS 920
                    + G ++L  ++ T  LQ VQ +A ++++  +++++ +  L   +   +E+  
Sbjct: 3730 AETKRKLMALGPIRLEQDQTTAQLQ-VQ-KAFSIDI--IRHKDSMDELFSHR---SEIFG 3782

Query: 921  SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHS-VEVCSF---LQECGP 976
            +  + ++      T +Q + E L Q++  +  L  E+  +L  + V V  F    +E  P
Sbjct: 3783 TCGEEQK------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836

Query: 977  TQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHF--LQSVVVKVEEPGYAE 1034
               + R ++ QL +      +      ++ Q +  + E + H   L  +  +++E    E
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896

Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARR--QAETQARQ--SFLQESQQLLLWAESVQAQL 1090
             + ++ + +  + +  Q++E+V QRA    +A +Q+ Q   F  + + +L   E++ ++L
Sbjct: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956

Query: 1091 RSKE-VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM------AALDCPDSQE 1143
            R    +  +V   +  + +++    E+   Q   + L  + + +      A  D   ++E
Sbjct: 3957 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKE 4015

Query: 1144 VPNTLRVLGQQGQELKVLWEQRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNL 1201
            + + L  +    +++K   E+R+    + LEL +KF  ++     T  + Q  +H L++ 
Sbjct: 4016 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4075

Query: 1202 G-------------EDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
            G             E ++E    L +  EF R+L      A+ + A GE    ++ P   
Sbjct: 4076 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG-----ADLIFACGE----TEKPE-- 4124

Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELM-QWMEEKGL-MAAHEP 1306
             VR+ +  +   W  L    ++R  +L  ++Q     QD  + M  W++   + +    P
Sbjct: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183

Query: 1307 SGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGL 1362
             G   N ++  L   +  + E+   +  +E L   G EL+ ++   + D   I+  L  L
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242

Query: 1363 RSKWEALNRKMTERGDELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
            +  WE L  K+  R  +L+ A    GQ +  L +L       E+L  A Q   +G     
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA-QRPISGDPKVI 4301

Query: 1419 SQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAI-- 1476
               L K H  L+++     A +  +    + +  S A  + +    R   + Q   ++  
Sbjct: 4302 EVELAKHHV-LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360

Query: 1477 ----RGLQLQASVELHQFCH---------LSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
                R  QLQ++++  Q  H         L+ ME    A     G P +  E L+     
Sbjct: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD----- 4415

Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSL------AASGHPQAQHIVEQCQELEGHWAELE 1577
               H EL  ++KA +    ++L  GR +      + SG    Q +      LE  W  + 
Sbjct: 4416 --THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL----LEQKWHVVS 4469

Query: 1578 RACEARAQCLQQAVTFQQYFLD-VSELEGWV---EEKRPLVSSRDYGRDEAATLRLINKH 1633
               E R   L++A+     F + + E   W+   E+   + S      +    L  I +H
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEH 4527

Query: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL---REQLRALQELAATRDRE 1690
            +    E+  +   + ELDQT   L      +   +++  L   + +   + + +  R R 
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587

Query: 1691 LEGTLRLHEFLREA-EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
            L+   +  +   EA + L  WL   +        +  DP+      +K  +FQ  +  G 
Sbjct: 4588 LDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG-GK 4646

Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQ----DLQTAWSELWELTQARGHALRDTETTL 1805
            Q V    +     L+   +  P   Q+      +++  W  +   +  R H L +     
Sbjct: 4647 QPVYDTTIRTGRALKE-KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFS 4705

Query: 1806 RVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE 1862
                D L+ L       E   +    V  DL  +   + +H+  ++EL G      ++L+
Sbjct: 4706 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKEL-GKRTGTVQVLK 4764

Query: 1863 TAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDYA 1921
             +GR            V+ + Q ++  W  + +    ++++LE+A   A  FR  V    
Sbjct: 4765 RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLL 4824

Query: 1922 SWAARVRQDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
             W +   Q L+   +  + +     L   H+    ++E +      A  +G+  L     
Sbjct: 4825 EWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 4884

Query: 1981 PTKEVQEELRALQDQRDQVYQTWARK-QERLQAEQQEQLFLRECGRLEEILAAQEVSLKT 2039
                  +    +   R +   TWA++ Q+RL+    E +   E   LEE+LA  + +  T
Sbjct: 4885 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL--LEELLAWIQWAETT 4942

Query: 2040 ------SALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRD-RLPIL 2092
                    +  +++ V+ LI +H+ F++ +T   +K+  +    KT +R  +     P +
Sbjct: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMT---RKQPDVDRVTKTYKRKNIEPTHAPFI 4999

Query: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQAWAQQLKEPVPPGDLR 2147
             + R   ++   S        + + S ++A        +  W Q W   L+      D  
Sbjct: 5000 EKSRSGGRK---SLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056

Query: 2148 DKLKPLLKHQAFEAEV 2163
            D+L+ L +   F+ +V
Sbjct: 5057 DRLEELKEFANFDFDV 5072



 Score =  144 bits (363), Expect = 2e-33
 Identities = 378/1897 (19%), Positives = 746/1897 (39%), Gaps = 238/1897 (12%)

Query: 826  DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLL 884
            D D   +    + ++  + +L      R A+L+EA+   G F  +   L  WL     L+
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300

Query: 885  QRVQPQADTLEVM--QLKYENFLTAL-----AVGKGLWAE---VSSSAEQLRQRYPGNST 934
               +P +   +V+  Q++ +  L  L     A    L AE   ++ SAE        +  
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL------ADRE 3354

Query: 935  QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCS-FLQECGPTQVQLRDVLLQLEALQP 993
            +I  Q E L  RW +L +    +  QL   + +   F +   P    L     +L   +P
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414

Query: 994  GSSEDTCHALQLAQKKTLVLERRVHFLQ-SVVVKVEEP-----GYAESQPLQGQVETLQG 1047
              ++      Q+ + K L  +   H       VK+ +        AE   L  ++++LQ 
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474

Query: 1048 LLKQVQEQVAQRARR--QAETQARQSFLQESQQLLLWAESVQAQL--------------- 1090
               ++Q++  ++A    QA + AR  F ++  ++L W   V+ +L               
Sbjct: 3475 RYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533

Query: 1091 --------------RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
                          R K V   + + Q LL+  Q   EE+ L QE+L  +  +   +   
Sbjct: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLK--QTTGEEVLLIQEKLDGIKTRYADITVT 3591

Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH---- 1192
                S +   TL    Q   + +  +E+   WL          REV+   AT        
Sbjct: 3592 ----SSKALRTLEQARQLATKFQSTYEELTGWL----------REVEEELATSGGQSPTG 3637

Query: 1193 ----QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP-RAEALRAHGEKLVQSQHPAA 1247
                Q       L ++V E   +L    E  R L  L P RA   R   +KLV   +   
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA---REGLDKLVSDANEQY 3694

Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL-QEWKQDVAELMQWMEE-KGLMAAHE 1305
              V + +               QR  ++ A++Q  Q+++Q     + W+ E K  + A  
Sbjct: 3695 KLVSDTIG--------------QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 3740

Query: 1306 PSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRP-----CGQED---IQT 1357
            P    ++  QT  + +  ++  +   RH +++     EL S R      CG+E    +Q 
Sbjct: 3741 PIRLEQD--QTTAQLQVQKAFSIDIIRHKDSMD----ELFSHRSEIFGTCGEEQKTVLQE 3794

Query: 1358 RLQGLRSKWEALNRKMTERGDELQQAG--------QQEQLLRQLQDAKEQLEQLEGALQS 1409
            + + L  ++EA++   +ER   L++A           E+L   +++ +  + QL      
Sbjct: 3795 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAID 3854

Query: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRL 1467
             E    LR  Q   ++ ++  +E +    K+  +      +       + E+ QK     
Sbjct: 3855 HE---QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMY 3911

Query: 1468 ELLQGHLAIRGLQLQASV-------ELHQFCH--LSNMELSWVAEHMPHGSPTSYT---E 1515
              ++  +  R L L  +V       E H      L  +E       MP   P       E
Sbjct: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
            C++  +S   + ++LQ   +A + + + ++  GRS  A     A+ I ++  ++   W +
Sbjct: 3972 CISDNKSATVELEKLQPSFEALKRRGEELI--GRSQGADKDLAAKEIQDKLDQMVFFWED 4029

Query: 1576 LE-RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY-GRDEAATLRLINKH 1633
            ++ RA E   + L      ++++ D++ L   +++ + +V   +  G D +   + +   
Sbjct: 4030 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA 4089

Query: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
            + ++EE       +E +      L       ++  V++ + E   A + L  T    LE 
Sbjct: 4090 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE- 4148

Query: 1694 TLRLHEFLREAEDLQG-------WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
              +L + ++ A   Q        WL +          +G D         +  +F+ +V 
Sbjct: 4149 --KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206

Query: 1747 MGSQRVAACRLLAESLLERG--HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
                 +       E +L++    +   ++R+   +L+  W  L E    R H L      
Sbjct: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266

Query: 1805 LRVHRDLLEVLTQV---QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
            L   +  LE L       E+       ++ D   +E +L  H  L+ +++  +  ++ + 
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326

Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDY 1920
            +    + +   G  A +++ R +A+ Q W  + ++ E+R  QL+     A+ F + + D+
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386

Query: 1921 ASWAARVRQDLQVEE-SSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-- 1977
                 R+   L   + +   P +   +L  H  L ++L+A+E+ + Q    G+  LL+  
Sbjct: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446

Query: 1978 -AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQL-----FLRECGRLEEILA 2031
             +G+ +K   E+  AL +Q+  V  +   K E  +++ +E L     F          L 
Sbjct: 4447 DSGSGSK--TEQSVALLEQKWHVVSS---KMEERKSKLEEALNLATEFQNSLQEFINWLT 4501

Query: 2032 AQEVSLKTSALGSSV-EEVEQLIRKHEVFLKVLTAQDKKEAALRE---RLKTLRRPR--- 2084
              E SL  ++  S +   V   I +H+VF   + A   +   L +   +LK L + +   
Sbjct: 4502 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 4561

Query: 2085 -VRDRLPILLQRRMRVKELAESRGHALHASLLMA-SFTQAATQAEDWIQAWAQQLKEPVP 2142
             +++ L  +  R  +V + +  RG +L  +   A  F +A  +  DW++     L   + 
Sbjct: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621

Query: 2143 PGDLRDKLK-PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG---- 2197
              +  DK+K  L KH+ F+  +   + V  +  + G AL  +      E SQ+L      
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--KEKTLLPEDSQKLDNFLGE 4679

Query: 2198 LRKHWEDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMNVGD-LGQDLEHC 2255
            +R  W+ +      R  +LE+   F  +F+  +     W+ + E ++     +  DL+  
Sbjct: 4680 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 4739

Query: 2256 LQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFH 2315
            + L    + F+    G   G   +   S   L   +RD  +   +  +  +L+ RW +  
Sbjct: 4740 MNLMDAHKVFQ-KELGKRTGTVQVLKRSGRELIENSRD--DTTWVKGQLQELSTRWDTVC 4796

Query: 2316 GNLLRYQQQLEGALE--------IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
               +  Q +LE AL+        +H+L   L    + ++ + AL        D E++Q L
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL------PDDTEALQSL 4850

Query: 2368 LRKHEELEREVHPIQAQVES---LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRA 2424
            +  H+E  ++V   +  V S   +   +  +C   P+    ++H    +   + ++ + A
Sbjct: 4851 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCH--PDCITTIKHWITIIRARFEEVLTWA 4908

Query: 2425 QKRREALD-ALHQAQKLQAMLQELLV---SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
            ++ ++ L+ AL +      +L+ELL     A+    Q D  P P++    + ++ EHQ  
Sbjct: 4909 KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 4968

Query: 2481 KAEL-------DSWTDS-------------ISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
              E+       D  T +             I  +RS G++ L+   P    I        
Sbjct: 4969 MEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5028

Query: 2521 QELSSLEGAWQE-HQLQLQQALELQLFLSSVEKMERW 2556
              ++ L   WQ+   L L++  +L   L  +E+++ +
Sbjct: 5029 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEF 5065



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 264/1272 (20%), Positives = 486/1272 (38%), Gaps = 175/1272 (13%)

Query: 247  SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
            S + Q + +    ++   +L+  ++L  Q+ +   +L  WI E +  +     P      
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDH 3855

Query: 307  RQLLAAFTIFRTQEKPPRLQQRGAAEAL-----LFRLQTALQAQNRRPFLPHEGLGLAEL 361
             QL       R Q++  R  +   AE       L ++   L+  N     P EG  + E 
Sbjct: 3856 EQL-------RQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN-----PEEGEMVEEK 3903

Query: 362  SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
             Q     E   A   + ++QR L L    + + +        E  L+  E +  + R PP
Sbjct: 3904 YQ---KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960

Query: 422  A---------------SLATVEA--------AVQRLGMLEAGILPQEGRFQALAEIADIL 458
                              ATVE         A++R G    G      +  A  EI D L
Sbjct: 3961 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4020

Query: 459  RQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQ 518
             Q  +  W D+  R EE  +++   L  L+   K   DM A+L+ +++ +   H LE   
Sbjct: 4021 DQMVFF-WEDIKARAEEREIKF---LDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-- 4074

Query: 519  EPARSTACGQQLAEVVELLQR-----HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
             P    +  +Q  E  E ++      H+ LE  +   GA +     +T + +        
Sbjct: 4075 -PGIDPSIIKQQVEAAETIKEETDGLHEELEF-IRILGADLIFACGETEKPE-------- 4124

Query: 574  VLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRVGNAA- 631
             ++     +    ++L    + R   LE  +Q A ++    +    WL     ++     
Sbjct: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183

Query: 632  LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG---ERAEAV 688
            +G DL+ +   L + K  + EV++ Q     L  +G +L  ++   + D     E    +
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242

Query: 689  QGGWQLLQTRVVGRGARLQTALLVLQYFADA-AEAASWLRERRSSL--ERASCGQDQAAA 745
            +  W+ L  ++  R  +L+ ALL L  F  A  E  SWL      L  +R   G  +   
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302

Query: 746  ETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEA 805
              L + HV    VL                 + +A++ TVN A +   ES       S  
Sbjct: 4303 VELAKHHVLKNDVL-----------------AHQATVETVNKAGNELLESSAGDDASSLR 4345

Query: 806  SCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG 865
            S        W+              ++LQ  +   Q  +S    AQ   + +E+    F 
Sbjct: 4346 SRLEAMNQCWE--------------SVLQKTEEREQQLQSTLQQAQGFHSEIED----FL 4387

Query: 866  FCSSCGELQLWLEKQT-VLLQRVQPQADT----LEVMQLKYENFLTALAVGKGLWAEVSS 920
               +  E QL   K T  L +  + Q DT       ++ K E +   L  G+ +      
Sbjct: 4388 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD 4447

Query: 921  SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
            S         G+ ++ ++    L Q+W  + +   E+  +L  ++ + +  Q      + 
Sbjct: 4448 S---------GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 4498

Query: 981  LRDVLLQ-LEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ 1039
               +  Q L    P S        Q+ + K    E   H  +  ++++++ G       Q
Sbjct: 4499 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH--RDQIIELDQTGNQLKFLSQ 4556

Query: 1040 GQ-VETLQGLLKQVQ---EQVAQRA--RRQAETQAR---QSFLQESQQLLLWAESVQAQL 1090
             Q V  ++ LL  VQ   E+V QR+  R ++   AR   + F +  ++L+ W E  ++ L
Sbjct: 4557 KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL 4616

Query: 1091 RSK-EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM--AALDCPDSQEVPNT 1147
             S+ E+S D    +  L +H++  + +   Q          + +    L   DSQ++ N 
Sbjct: 4617 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 4676

Query: 1148 LRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL--DNLGE-- 1203
            L  +  +   +     +RQ  L+E L     G+ +D   A       WL+     L E  
Sbjct: 4677 LGEVRDKWDTVCGKSVERQHKLEEALLFS--GQFMDALQALV----DWLYKVEPQLAEDQ 4730

Query: 1204 ----DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
                D+   ++L+  H+ F + L       + L+  G +L+++       V+ QLQ +  
Sbjct: 4731 PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELST 4790

Query: 1260 QWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNI 1313
            +W  +   S  ++ +L  +L Q + ++  V  L++W+ E     +   A  + + A +++
Sbjct: 4791 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSL 4850

Query: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
            + T   H+    ++   R  V +   +G  +L+   C  + I T        W  + R  
Sbjct: 4851 IDT---HKEFMKKVEEKRVDVNSAVAMGEVILA--VCHPDCITT-----IKHWITIIRAR 4900

Query: 1374 TERGDELQQAGQQ--EQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK---RHQQ 1428
             E      +  QQ  E  L +L    E LE+L   +Q +ET    R  + + +   R + 
Sbjct: 4901 FEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKA 4960

Query: 1429 LESESRTLAAKM 1440
            L +E +T   +M
Sbjct: 4961 LIAEHQTFMEEM 4972



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 301/1593 (18%), Positives = 560/1593 (35%), Gaps = 312/1593 (19%)

Query: 1947 LSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARK 2006
            L   + LR  +E  E L Q A ++   AL           EE   L     Q        
Sbjct: 413  LEREKSLRPAVERLELLLQIANKIQNGALNC---------EEKLTLAKNTLQADAAHLES 463

Query: 2007 QERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQ 2066
             + +Q E    ++++EC   E ++   +V L+       +   E   +  E+  +V+  Q
Sbjct: 464  GQPVQCESDVIMYIQEC---EGLIRQLQVDLQ-------ILRDENYYQLEELAFRVMRLQ 513

Query: 2067 DKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKEL-AESRGHALHASLLMASFTQAATQ 2125
            D+    LR     L R      L ++    +    L AE    A H+S   + F +  T+
Sbjct: 514  DEL-VTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSST-SWFRKPMTR 571

Query: 2126 AE--------------------DWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
            AE                     W++    +L+      DL           + E +++ 
Sbjct: 572  AELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL----------PSVELQLET 621

Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQR--------LQGLRKHWEDLRQAMALRGQELE 2217
             + + TSV + G ++  ++    G++SQ         L  L   +  L++  + R + L+
Sbjct: 622  QQHIHTSVEELGSSV-KEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ 680

Query: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277
                  +F+ R      W+ EKE +    D   +  +    R    E             
Sbjct: 681  SLH---KFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK---QD 734

Query: 2278 CIRSISDLS--LQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVL- 2334
              RS+ D +  L L+N   +          Q    +++   + L++ +QL   +E HV  
Sbjct: 735  VFRSLQDTAELLSLENHPAK----------QTVEAYSAAVQSQLQWMKQLCLCVEQHVKE 784

Query: 2335 ----------SRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ 2384
                      +REL++  + +Q+      + D    L  ++ LL+   + + ++   ++ 
Sbjct: 785  NTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSS 844

Query: 2385 VESL---EREVGRLCQRSPEAAHGLR----------HRQQEVA---ESWWQLRSRAQKRR 2428
            V SL    + + +L  RSP+  H L+          +RQ E+         L   +Q+ +
Sbjct: 845  VASLVGRSKTIVQLKPRSPD--HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902

Query: 2429 ---------EAL-------------DALHQA-------QKLQAMLQEL------LVSAQR 2453
                     EA+             DA+  A       QK+ A+  +L      L+S   
Sbjct: 903  WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962

Query: 2454 LRAQMDT----------SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT 2503
            LR  +D           S AP    +  + L+ H E    L    DS+  + +   +L  
Sbjct: 963  LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL-- 1018

Query: 2504 AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDS 2563
                   ++    A  +  + S+E   +E  +      EL+     +E+ E+ +  +  S
Sbjct: 1019 -----EEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQS 1073

Query: 2564 LASE----GLWDP----LAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEA 2615
            LAS       W      +A  E      + L  DL+  + K  +       LHQ   P +
Sbjct: 1074 LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF------LHQS--PSS 1125

Query: 2616 QSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLR--EKNLVALEE 2673
             S       + L  E +    G     L +L+ +   ++  Q+    ++  E  L   E 
Sbjct: 1126 SSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185

Query: 2674 GLLDTAMLPAQLQKQQNFQAE----------LDASMHQQQELQREGQRLLQGGHPASEAI 2723
             L D + L A     +++ ++          LD  + + + +  +  RL    +   E  
Sbjct: 1186 VLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245

Query: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME-ELENWLEPIEVELRAPTVGQ 2782
            QE+  +L   W  +    + + ++L+   E L   R+    L  W+E    +      GQ
Sbjct: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305

Query: 2783 ALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKS 2842
            A      +L  Q   + A+  +  + +  L Q Q F ++   + +D E Q        +S
Sbjct: 1306 AEDS--RVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363

Query: 2843 LREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQN 2902
             ++   +RR  L +   + + F D           L     Q       A+R L+E+ + 
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYT----ALVTLTTQHVKYISDALRRLEEEEKV 1419

Query: 2903 LESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ-QLEKAMAHLRAEAARRRLLLQ 2961
            +E E   H    + +LG    L +     A     +    +EKA+  L  +     L  +
Sbjct: 1420 VEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI--LEQQVLSEELTTK 1477

Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
            + Q ++   T  +    +LA+ GH L  +                               
Sbjct: 1478 KEQVSEAIKTSQI----FLAKHGHKLSEK------------------------------- 1502

Query: 3022 RLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLL 3081
                           E  ++  QL A+ +A+ +L   +  +   LQ QL  HQ E++TL 
Sbjct: 1503 ---------------EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA-HQTEQKTL- 1545

Query: 3082 LDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGA 3141
                        +     Q LE +                +GQA+    R LAG   R  
Sbjct: 1546 ----------QKQQNTCHQQLEDL-------------CSWVGQAE----RALAGHQGRTT 1578

Query: 3142 PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMK 3201
             +    +Q  +S ++   + +              +   SF     +++G M+E    + 
Sbjct: 1579 QQDLSALQKNQSDLKDLQDDIQ-------------NRATSFATVVKDIEGFMEENQTKLS 1625

Query: 3202 GEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KV 3257
              +       +   ++Q+  L+ E    +KE+    T A +       A   LA    K+
Sbjct: 1626 PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKI 1685

Query: 3258 QEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQL 3317
                  + +     GQ L         L   ++L   + E+  L +++         E+L
Sbjct: 1686 DALLDWVTSVGSSGGQLLTN-------LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 1738

Query: 3318 LGQHEELGQEIRECRLQAQDL---RQEGQQLVD-NSHFMSAEVTECLQELEGRLQE---- 3369
              Q E +    +E   Q Q+     Q  Q  +D + H ++ E  + LQ+  G L+E    
Sbjct: 1739 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 1798

Query: 3370 -LEEAWALRWQRCAESWGLQKLRQRLEQAEAWL 3401
             L ++ A   Q       LQK  Q  ++ E+WL
Sbjct: 1799 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831



 Score = 42.4 bits (98), Expect = 0.009
 Identities = 94/454 (20%), Positives = 171/454 (37%), Gaps = 70/454 (15%)

Query: 3023 LQQTAALLESRKNPESPKVLAQL--QAVREAHAELLRRAEARGHGLQEQLQLHQLERETL 3080
            ++Q   L+  +  P++P  L  L  Q +     E+L +   +G          ++E    
Sbjct: 330  IKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG----------RIEELYK 379

Query: 3081 LLDAWLTTKAATAESQDYGQDLE---GVKVLE--EKFDAFRKEVQSLGQAKVYALRKLAG 3135
            LL+ W+           +  D+E   G  ++E  E+  + R  V+ L       L ++A 
Sbjct: 380  LLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE-----LLLQIAN 434

Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
             ++ GA      +   ++ ++A    L+     + E+     +V  + Q    L  ++Q 
Sbjct: 435  KIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCES-----DVIMYIQECEGLIRQLQV 489

Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA 3255
               +++ E+       +  L  +  RL+ EL  +  E   L  +      L    P  L 
Sbjct: 490  DLQILRDEN----YYQLEELAFRVMRLQDELVTLRLECTNLYRKG-HFTSLELVPPSTLT 544

Query: 3256 KVQ-EAWATLQAKAQERGQWLAQ-----------AAQGHAFLGRCQELLAWAQERQELAS 3303
                +A    +A       W  +           +++    L    ELL+W +E Q    
Sbjct: 545  TTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604

Query: 3304 SEELAEDVAGAEQLL--GQH-----EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEV 3356
              E   D+   E  L   QH     EELG  ++E RL    + Q       N H   AE 
Sbjct: 605  RAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ-------NFHTSYAET 657

Query: 3357 TECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEA---WLACWEGLLLKPDY 3413
               L +LE +  +L+E  + R +       LQ L + + +A A   WL   E   L  D+
Sbjct: 658  ---LGKLETQYCKLKETSSFRMRH------LQSLHKFVSRATAELIWLNEKEEEELAYDW 708

Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
              + S++    +   +L   L  +++ F  +Q T
Sbjct: 709  SDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 46/261 (17%), Positives = 103/261 (39%), Gaps = 7/261 (2%)

Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQ-L 3246
            EL   ++E    ++  + G+ L SV    +  + +   +E +   V   +    ++ Q  
Sbjct: 591  ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNF 650

Query: 3247 HPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEE 3306
            H +    L K++  +  L+  +  R + L      H F+ R    L W  E++E   + +
Sbjct: 651  HTSYAETLGKLETQYCKLKETSSFRMRHLQSL---HKFVSRATAELIWLNEKEEEELAYD 707

Query: 3307 LAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGR 3366
             +++ +          EL  E+ E +   + L+   + L   +H     V      ++ +
Sbjct: 708  WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767

Query: 3367 LQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP---DYGHSVSDVELL 3423
            LQ +++      Q   E+    +      + E++L   +  + +    D+  S+S +E L
Sbjct: 768  LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827

Query: 3424 LHRHQDLEKLLAAQEEKFAQM 3444
            L    D ++ L   +   A +
Sbjct: 828  LQDSMDEKEQLIQSKSSVASL 848


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score =  345 bits (885), Expect = 5e-94
 Identities = 209/564 (37%), Positives = 312/564 (55%), Gaps = 27/564 (4%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  +G+ L+ LLE+ISGE LP P +G++R H
Sbjct: 45  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFH 102

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 103 KIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEET---- 158

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVN+ +F  SW DGL   ALIH HRPDL+DY  LR D
Sbjct: 159 -----SAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKD 213

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            P+ NL  AF VAE+ L I ++LD ED+    +PDE++IMTYVS +YH  +   Q +T  
Sbjct: 214 DPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAA 273

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L  +YE+L ++LL WI      LE R    S+ AM++ L  F  +
Sbjct: 274 NRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDY 333

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R   KPPR+Q++   E     LQT L+  +R  F+P EG  +++++  W GLE  E    
Sbjct: 334 RRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYE 393

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
             L   + +LQRL+ LA +F+ KA+L E++ +  E++L Q     A L  V A ++R   
Sbjct: 394 DWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEA 453

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            E+ +   + R + +A +A  L +  YH  A V  R + +  +W  L    Q +R  +  
Sbjct: 454 FESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER 513

Query: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR----HDLLEAQ--VSAH 550
           M+ +L  + ++        +L+   R+      L   VE LQ     H + E Q  ++AH
Sbjct: 514 MEKLLETIDQL--------QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565

Query: 551 GAHVSHLAQQTAELDSSLGTSVEV 574
               + L +   E  + +G   E+
Sbjct: 566 DQFKATLPEADRERGAIMGIQGEI 589



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 96/408 (23%), Positives = 166/408 (40%), Gaps = 36/408 (8%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852
            Q + +  ++    Q +  L    AF+     L  D+    R L Q  K   +  L E R 
Sbjct: 343  QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402

Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
                + L  KF + A    AW + K  + + +DY  + L  VR L  +H+  ES++++H+
Sbjct: 403  LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  +  A  V +R Q +     +L     +RR  L++ ++  + + 
Sbjct: 463  DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522

Query: 2972 EL--------LEAGSWLAERGHVLDSED--MGHSAEATQALLRRLEATKRDL-EAFSPR- 3019
            +L            +WL   G V D +D  + HS E TQ+LL   +  K  L EA   R 
Sbjct: 523  QLQLEFARRAAPFNNWL--DGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580

Query: 3020 --------IERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL- 3070
                    I+++ QT  L   R    +P +    Q +      + +   +R   LQE+L 
Sbjct: 581  AIMGIQGEIQKICQTYGL---RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637

Query: 3071 --QLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVK-VLEEKFDAFRKEVQSLGQAKV 3127
              Q+++  R      A        A+ ++ G+   G+   LEE+    R++ Q++   K 
Sbjct: 638  RQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697

Query: 3128 YALRKLAG---TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
              + +L G    L+        H       I   WE+L  +I ART N
Sbjct: 698  -NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI-ARTIN 743



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 91/382 (23%), Positives = 149/382 (39%), Gaps = 49/382 (12%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI     GLEQ     E  W   +++ 
Sbjct: 344  EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED-WLLSEIRR 402

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP-MEPLLWKHKMLEWDLEVQA 2594
             Q L+   + F       E W   KE+ L+       L   +  LL +H+  E DL    
Sbjct: 403  LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQ 2654
             ++  + A A+ L++  + EA S   RCQA+  + + L      RR  LE +        
Sbjct: 463  DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM-------- 514

Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL-----QREG 2709
                      EK L  +++  L+ A      ++   F   LD ++   Q++       E 
Sbjct: 515  ----------EKLLETIDQLQLEFA------RRAAPFNNWLDGAVEDLQDVWLVHSVEET 558

Query: 2710 QRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLE 2769
            Q LL         + E   E GA+ G +Q        ++QK C+   LR         L 
Sbjct: 559  QSLLTAHDQFKATLPEADRERGAIMG-IQ-------GEIQKICQTYGLRPCSTNPYITLS 610

Query: 2770 PIEVELRAPTVGQALPG----VGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE---- 2821
            P ++  +   V + +P     + E L  Q+  E    + A QA A+    QA V E    
Sbjct: 611  PQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRL 670

Query: 2822 GHCLAQDVEEQARRLLQRFKSL 2843
               LA  +EEQ   L Q+ +++
Sbjct: 671  AAGLAGSLEEQMAGLRQQEQNI 692



 Score = 53.1 bits (126), Expect = 5e-06
 Identities = 60/252 (23%), Positives = 106/252 (42%), Gaps = 36/252 (14%)

Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
            E L+ +     W++ +  + ++  + + LE         R++R       + + C   I+
Sbjct: 299  ELLEWIRRTVPWLENRVGEPSMSAMQRKLED-------FRDYRRLHKPPRIQEKCQLEIN 351

Query: 2284 DLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
              +LQ K R        P E K++    S + N W         Y+  L    EI  L R
Sbjct: 352  FNTLQTKLRLSHRPAFMPSEGKLV----SDIANAWRGLEQVEKGYEDWLLS--EIRRLQR 405

Query: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384
             L ++ ++ ++K +L +A   GK+            L+ V+ LLR+HE  E ++   Q +
Sbjct: 406  -LQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464

Query: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML 2444
            VE +      L +     A  +  R Q + + W  L +  QKRR   DAL + +KL   +
Sbjct: 465  VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRR---DALERMEKLLETI 521

Query: 2445 QELLVSAQRLRA 2456
             +L +   R  A
Sbjct: 522  DQLQLEFARRAA 533



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 30/118 (25%), Positives = 55/118 (46%), Gaps = 1/118 (0%)

Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
            L   F Q A+  E W +   + L +      L  +++ LL+ H+AFE+++ AH++ +  +
Sbjct: 409  LAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDL 2231
            A   + L    +  A  V+ R Q +   W++L      R   LE     LE + ++ L
Sbjct: 469  AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQL 526



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 45/264 (17%)

Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWLH-----LDNLGED---VREALSLLQQHR 1216
            + WL  E   LQ+     + F    + H+AW       L     D   ++E  +LL++H 
Sbjct: 393  EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHE 452

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL- 1275
             F   L+    R E + A  ++L +  +  A +V  + Q+I  QW  L   +++RR  L 
Sbjct: 453  AFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE 512

Query: 1276 --------LASLQLQ---------EWKQDVAELMQ--WM-----EEKGLMAAHEPSGARR 1311
                    +  LQL+          W     E +Q  W+     E + L+ AH+   A  
Sbjct: 513  RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA-- 570

Query: 1312 NILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED-IQTRLQGLRSKWEALN 1370
                TL   +     ++  +  ++ + Q        RPC     I    Q + +KW+ + 
Sbjct: 571  ----TLPEADRERGAIMGIQGEIQKICQT----YGLRPCSTNPYITLSPQDINTKWDMVR 622

Query: 1371 RKMTERGDELQQAGQQEQLLRQLQ 1394
            + +  R   LQ+   ++Q+  +L+
Sbjct: 623  KLVPSRDQTLQEELARQQVNERLR 646



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 78/362 (21%), Positives = 141/362 (38%), Gaps = 59/362 (16%)

Query: 442 LPQEGRFQALAEIADILR-----QEQYHSW--ADVARRQEEVTVRWQRLLQHLQGQRKQV 494
           +P EG+   +++IA+  R     ++ Y  W  +++ R Q          LQHL  + +Q 
Sbjct: 368 MPSEGKL--VSDIANAWRGLEQVEKGYEDWLLSEIRRLQR---------LQHLAEKFRQK 416

Query: 495 ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHV 554
           A +    +  +E        E L +    +A    L EV  LL+RH+  E+ ++AH   V
Sbjct: 417 ASLHEAWTRGKE--------EMLSQRDYDSAL---LQEVRALLRRHEAFESDLAAHQDRV 465

Query: 555 SH---LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQ------ 605
            H   LAQ+  ELD     SV    ++ + +     +L  L + RR  LE+  +      
Sbjct: 466 EHIAALAQELNELDYHEAASV---NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522

Query: 606 --RAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKH---KALEAEVHRHQAVC 660
             + EF R       WL    + + +  L   + +    L  H   KA   E  R +   
Sbjct: 523 QLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582

Query: 661 V----DLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL------ 710
           +    ++ +  +    R   T P      + +   W +++  V  R   LQ  L      
Sbjct: 583 MGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVN 642

Query: 711 --LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRR 768
             L  Q+ A A     W++ +   + R + G   +  E +     + + ++  +   + R
Sbjct: 643 ERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIIN-YKTNIDR 701

Query: 769 LE 770
           LE
Sbjct: 702 LE 703



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 70/338 (20%), Positives = 128/338 (37%), Gaps = 25/338 (7%)

Query: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
           G   Q+R   L ++   L+  + LQ ++ +  A    W+      L+      S+   + 
Sbjct: 501 GTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQS 560

Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFL--PHEGLGLAELSQCWA 366
           LL A   F+    P   ++RGA   +   +Q   Q    RP    P+  L   +++  W 
Sbjct: 561 LLTAHDQFKAT-LPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWD 619

Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
            +     +R Q LQ+ L + Q  E L R+F  +A     +++   +V +  R       +
Sbjct: 620 MVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ--AKVEEVGRLAAGLAGS 677

Query: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQH 486
           +E  +  L   E  I+  +     L     +L++             E + V W++LL  
Sbjct: 678 LEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTS 737

Query: 487 LQGQRKQVADMQAVLSL-------LQEVEAASHQLEE----LQEPARSTAC----GQQLA 531
           +     +V +              L E  A+ +  +     + EP    AC    G  L 
Sbjct: 738 IARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLG 797

Query: 532 EV--VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSS 567
           EV    ++   D   A V    A +  + ++TAE D++
Sbjct: 798 EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTT 835



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 92/480 (19%), Positives = 181/480 (37%), Gaps = 89/480 (18%)

Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEK---------RPLVSSRDYGRDEAATLR 1628
            R C+  A   +     ++Y    SEL  W+             P +S+     ++    R
Sbjct: 275  RICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYR 334

Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678
             ++K   +QE  +L I ++++    QT   L+     +P + ++V +       L +  +
Sbjct: 335  RLHKPPRIQEKCQLEINFNTL----QTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEK 390

Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              ++   +  R L+    L E  R+   L + W   +++     +      +    L  +
Sbjct: 391  GYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRR 450

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
               F+  +     RV     LA+ L E  +     V  R Q +   W  L  LTQ R  A
Sbjct: 451  HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510

Query: 1798 LRDTETTLRVHRDLLEVLTQVQ----EKATSLPN---NVARDLCGL---------EAQLR 1841
            L   E        LLE + Q+Q     +A    N       DL  +         ++ L 
Sbjct: 511  LERME-------KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLT 563

Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLC------PGPQAHAVQQRQQAVTQAWAVLQR 1895
            +H   +  L   +R+   ++   G +QK+C      P      +    Q +   W ++++
Sbjct: 564  AHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK 623

Query: 1896 RMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRA 1955
             +  R   L+    LAR             +V + L+ + ++Q  + GP       W++A
Sbjct: 624  LVPSRDQTLQEE--LAR------------QQVNERLRRQFAAQANAIGP-------WIQA 662

Query: 1956 ELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
            ++E          ++G+ A   AG+    ++E++  L+ Q   +   +    +RL+ + Q
Sbjct: 663  KVE----------EVGRLAAGLAGS----LEEQMAGLRQQEQNII-NYKTNIDRLEGDHQ 707



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 83/429 (19%), Positives = 157/429 (36%), Gaps = 49/429 (11%)

Query: 2855 EARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALT 2914
            E   L+ ++ + A E + W++  +P    +    S+SA++   E  ++            
Sbjct: 285  ENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQE 344

Query: 2915 RVVLGTGYKLVQAGHFAAHEVAAR----------------VQQLEKAMAHLRAEAARRRL 2958
            +  L   +  +Q     +H  A                  ++Q+EK          RR  
Sbjct: 345  KCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQ 404

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EATQALLRRLEATKRDLEAFS 3017
             LQ   E  +    L EA  W   +  +L   D   +  +  +ALLRR EA + DL A  
Sbjct: 405  RLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462

Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQ---------E 3068
             R+E +   A  L      E+  V ++ QA+ +    L    + R   L+         +
Sbjct: 463  DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK-- 3126
            QLQL +  R     + WL       +       +E  + L    D F+  +    + +  
Sbjct: 523  QLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581

Query: 3127 ----VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL---AAAHEV 3179
                   ++K+  T         P+I      I   W+ + + + +R + L    A  +V
Sbjct: 582  IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641

Query: 3180 HS--FQQAAAE-------LQGRMQEKTALMKGEDGG--HSLSSVRTLQQQHRRLERELEA 3228
            +    +Q AA+       +Q +++E   L  G  G     ++ +R  +Q     +  ++ 
Sbjct: 642  NERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR 701

Query: 3229 MEKEVARLQ 3237
            +E +   LQ
Sbjct: 702  LEGDHQLLQ 710



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 36/199 (18%)

Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
            +D R  +RL K  +     QLE    TL  K         M +   +   +A +   LE+
Sbjct: 328  EDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQ 387

Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             +K         +RRL+ LQ HLA             +F   +++  +W        S  
Sbjct: 388  VEKGYEDWLLSEIRRLQRLQ-HLA------------EKFRQKASLHEAWTRGKEEMLSQR 434

Query: 1512 SYTECL-NGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             Y   L    ++L R+H+  + ++ AHQ +V+ + +  + L    + +A  +  +CQ + 
Sbjct: 435  DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494

Query: 1571 GHWAELERACEARAQCLQQ 1589
              W  L    + R   L++
Sbjct: 495  DQWDNLGTLTQKRRDALER 513



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 64/278 (23%), Positives = 112/278 (40%), Gaps = 32/278 (11%)

Query: 1994 DQRDQVYQTWARKQ-ERLQAEQQEQLFLRECGRLEEILAA--QEVSLKTSALGSSVEEVE 2050
            +Q ++ Y+ W   +  RLQ  Q      R+   L E      +E+  +     + ++EV 
Sbjct: 386  EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445

Query: 2051 QLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKELAE 2104
             L+R+HE F   L A QD+ E  AAL + L  L       V  R   +  +   +  L +
Sbjct: 446  ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505

Query: 2105 SRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKH 2156
             R  AL            L   F + A    +W+    + L++      + +    L  H
Sbjct: 506  KRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565

Query: 2157 QAFEAEV-QAHEEVMTSVAKKGE-ALLAQSH-----PRAGEVSQRLQGLRKHWEDLRQAM 2209
              F+A + +A  E    +  +GE   + Q++          ++   Q +   W+ +R+ +
Sbjct: 566  DQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLV 625

Query: 2210 ALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239
              R Q L++   R+   E L+R   A+A     WIQ K
Sbjct: 626  PSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 67/353 (18%), Positives = 135/353 (38%), Gaps = 39/353 (11%)

Query: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEI 1116
            QR +  AE   +++ L E+     W    +  L  ++  S  +   + LLR H+    ++
Sbjct: 404  QRLQHLAEKFRQKASLHEA-----WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458

Query: 1117 HLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQ 1176
               Q+R++ + A +Q +  LD  ++  V +  + +  Q   L  L ++R+  L+    ++
Sbjct: 459  AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE---RME 515

Query: 1177 KFGREVD----GFTATCANHQAWLHLDNLGED---------VREALSLLQQHREFGRLLS 1223
            K    +D     F    A    W  LD   ED         V E  SLL  H +F   L 
Sbjct: 516  KLLETIDQLQLEFARRAAPFNNW--LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP 573

Query: 1224 TLG-PRAEALRAHGE--KLVQSQ--HPAAHT--VREQLQSIQAQW--------TRLQGRS 1268
                 R   +   GE  K+ Q+    P +    +    Q I  +W        +R Q   
Sbjct: 574  EADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633

Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
            E+  RQ +     +++      +  W++ K        +G   ++ + +      E  ++
Sbjct: 634  EELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNII 693

Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQ 1381
              + +++ L+   + L        +     ++ +R  WE L   +    +E++
Sbjct: 694  NYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVE 746



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 1/54 (1%)

Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSV-SDVELLLHRHQDLEKLLAAQEEK 3440
            +K RQ+    EAW    E +L + DY  ++  +V  LL RH+  E  LAA +++
Sbjct: 411  EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score =  344 bits (882), Expect = 1e-93
 Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  DG+ L+ LLE+ISGE L  P RG++RVH
Sbjct: 31  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 89  KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVNI +F  SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            PL NL  AF VAE+ L I ++LD ED V  A+PDE++IMTYVS +YH  S   + +T  
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L   YE+L +DLL WI      LE R   +++ AM+Q L  F  +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R   KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE  E    
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
           + L   + +L+RL+ LA +F+ KA++ E++    E +L Q     A+L+ ++A +++   
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            E+ +   + R + +A IA  L +  Y+    V  R +++  +W  L    Q +R+ +  
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499

Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
            + +L  + ++       AA  ++ +E   E  + T     + E+  L   H+  +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
            + LE+++R      W++ +  +  +  + Q LE         R++R       V + C  
Sbjct: 285  DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334

Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
             I+  +LQ K R        P E +++    S +NN W         Y++ L    EI  
Sbjct: 335  EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388

Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
            L R LD++ ++ ++K ++ +A   GK+            L  ++ LL+KHE  E ++   
Sbjct: 389  LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
            Q +VE +      L +     +  +  R Q++ + W  L +  QKRREAL+   + +KL 
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504

Query: 2442 AMLQEL 2447
              + +L
Sbjct: 505  ETIDQL 510



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
            Q + +  ++    Q +  L    AF+     +  D+      L Q  K   E L      
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
            LE    L + FR  A    AW   K  +   +DY  + LS ++ L ++H+  ES++++H+
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  ++ +  V AR Q++     +L A   +RR  L++ ++  + + 
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508

Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
            +L            +W+      L    + H+ E  Q L    E  K  L
Sbjct: 509  QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)

Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
            LE   + LQ+ +     P +  S+  +   +    G L+QV+    E +    RR +   
Sbjct: 334  LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393

Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               + F Q++     W +  +A LR K+  +  ++  + LL++H+    ++   Q+R++Q
Sbjct: 394  HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
            + A +Q +  LD  DS  V    + +  Q   L  L ++R++ L+     +K    +D  
Sbjct: 454  IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510

Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
                A   A    W+   +++L +      + E   L   H +F   L      R   L 
Sbjct: 511  YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570

Query: 1234 AHGE--KLVQSQH 1244
             H E  K+VQ+ H
Sbjct: 571  IHNEVSKIVQTYH 583



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)

Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
            L   F Q A+  E W       L++         ++K LLK H+AFE+++ AH++ +  +
Sbjct: 395  LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
            A   + L    +  +  V+ R Q +   W++L      R + LE     LE + ++ L  
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 2234 A 2234
            A
Sbjct: 515  A 515



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 330  EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
             + L+   + F       E W   KE  L  +      L+ ++ LL KH+  E DL    
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
             ++  + A A+ L++  + ++ S   RCQ +  + + L      RR  LE   +L
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 41.6 bits (96), Expect = 0.015
 Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)

Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
            AQ  E  A R+ +     +E  Q      +  S LL++ R     + W++ ++P      
Sbjct: 252  AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
              Q L   R  +  H+  + +      +    L T  +L     F   E           
Sbjct: 309  MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
              ++Q+EK          RR   L    E  +    + EA  W   +  +L  +D   + 
Sbjct: 369  GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426

Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
                +ALL++ EA + DL A   R+E++   A  L      +SP V A+ Q + +     
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
             A  +  R A  R   L E +    LE  +     + W+  + A  + QD       +++
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544

Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
            +G+    E+F     DA ++ +  LG      + K+  T         P+       I  
Sbjct: 545  QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602

Query: 3158 AWERLDQAIKARTENLAAAH 3177
             W+ + Q +  R + L   H
Sbjct: 603  KWDHVRQLVPRRDQALTEEH 622



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
            EQ++    +W      +E RR + L  L  ++++Q  +    W + K  M   +   +  
Sbjct: 372  EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426

Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
               I   LK+HEA ES+L A +  VE +  + +EL          +  R Q +  +W+ L
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
                 +R + L++  +  + + QL     + A      +EGA   LQ +     +   Q 
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 1422 LQKRHQQLES 1431
            L   H+Q ++
Sbjct: 547  LTTAHEQFKA 556



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
           L+E+  LL++H+  E+ ++AH   V  +A    EL+         + A+ + +     +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
            AL + RR  LE+T +  E +     E A        W++   + + +  +   + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 642 ALQKHKALEA 651
               H+  +A
Sbjct: 547 LTTAHEQFKA 556



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)

Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
            CL+++E   +E    W L   R  E      +K RQ+    EAW    E +L + DY  +
Sbjct: 370  CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425

Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
             +S+++ LL +H+  E  LAA +++  Q+     E
Sbjct: 426  TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)

Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
            +D R  +RL K  +     QLE    TL  K         M +   M   +  +   LE+
Sbjct: 314  EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373

Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             +K         +RRLE L  HLA             +F   +++  +W           
Sbjct: 374  VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             Y T  L+  ++L +KH+  + ++ AHQ +V+++ +  + L    +  +  +  +CQ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
              W  L    + R + L++      T  Q +L+ ++       W+E
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)

Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
            ++WL  E   L++     + F    + H+AW           D     + E  +LL++H 
Sbjct: 379  EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
             F   L+    R E + A  ++L +  +  + +V  + Q I  QW  L   +++RR  L 
Sbjct: 439  AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498

Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
             + +L         E+ +  A    WME           GA  ++  T   H   E + L
Sbjct: 499  RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547

Query: 1329 AT 1330
             T
Sbjct: 548  TT 549



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)

Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
            R C+  A   +     + Y    S+L  W+    P + +R             ++    R
Sbjct: 261  RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320

Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
             ++K   +QE  +L I ++++    QT   L+     +P + R+V +       L +  +
Sbjct: 321  RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376

Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              +E      R LE    L E  R+   + + W   ++   +  +           L  K
Sbjct: 377  GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
               F+  +     RV     +A+ L E  +   P V  R Q +   W  L  LTQ R  A
Sbjct: 437  HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496

Query: 1798 LRDTETTL 1805
            L  TE  L
Sbjct: 497  LERTEKLL 504



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)

Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
            +  ++D +++A+    W+R + +  LE  + +  M   Q QK ++F+      +H+  ++
Sbjct: 273  EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328

Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
            Q + Q          +L     PA    + R+  ++   WG L+           N  ++
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
            + +L    E  R + S+ E   W +  E  LR      A L  +  LL      E+ +  
Sbjct: 389  LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446

Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
               + E +   AQ      +  +  V  + +++  ++ +L    Q+RR ALE    LL+ 
Sbjct: 447  HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506

Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
                  E A        W++  +          ++  ++ L   H+  ++ +   +    
Sbjct: 507  IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566

Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
             +LG      K+VQ  H              Q++     H+R    RR   L +    Q 
Sbjct: 567  AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626

Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
                   QF  +    G W+  +   +   S +M  + E   + LR+ E   + +  + P
Sbjct: 627  HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683

Query: 3019 RIERLQQTAALLE 3031
            +I++L+    L++
Sbjct: 684  KIDQLEGDHQLIQ 696



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)

Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
            S G MV     D+  AW          E W L + R    L       R    + E  T 
Sbjct: 356  SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411

Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
             +E      +     L  ++A L+ H+  E +L   + +++++   A  + +L     + 
Sbjct: 412  GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470

Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
            +V  R Q +   W  L    ++RR  LER  +LL        +YA       +W     +
Sbjct: 471  SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530

Query: 1930 DLQ 1932
            DLQ
Sbjct: 531  DLQ 533



 Score = 32.3 bits (72), Expect = 8.8
 Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)

Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
            +LER   LA +FR     + +W       L Q +  +   S     L  H+   ++L A 
Sbjct: 388  RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
            +   +Q   + Q+        +  V    + + DQ D +     +++E L+  ++     
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507

Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
            +QL+L    R       +      L+ + +  ++EE++ L   HE F   L   DK+  A
Sbjct: 508  DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567

Query: 2073 L 2073
            +
Sbjct: 568  I 568


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score =  344 bits (882), Expect = 1e-93
 Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  DG+ L+ LLE+ISGE L  P RG++RVH
Sbjct: 31  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 89  KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVNI +F  SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            PL NL  AF VAE+ L I ++LD ED V  A+PDE++IMTYVS +YH  S   + +T  
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L   YE+L +DLL WI      LE R   +++ AM+Q L  F  +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R   KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE  E    
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
           + L   + +L+RL+ LA +F+ KA++ E++    E +L Q     A+L+ ++A +++   
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            E+ +   + R + +A IA  L +  Y+    V  R +++  +W  L    Q +R+ +  
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499

Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
            + +L  + ++       AA  ++ +E   E  + T     + E+  L   H+  +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
            + LE+++R      W++ +  +  +  + Q LE         R++R       V + C  
Sbjct: 285  DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334

Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
             I+  +LQ K R        P E +++    S +NN W         Y++ L    EI  
Sbjct: 335  EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388

Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
            L R LD++ ++ ++K ++ +A   GK+            L  ++ LL+KHE  E ++   
Sbjct: 389  LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
            Q +VE +      L +     +  +  R Q++ + W  L +  QKRREAL+   + +KL 
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504

Query: 2442 AMLQEL 2447
              + +L
Sbjct: 505  ETIDQL 510



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
            Q + +  ++    Q +  L    AF+     +  D+      L Q  K   E L      
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
            LE    L + FR  A    AW   K  +   +DY  + LS ++ L ++H+  ES++++H+
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  ++ +  V AR Q++     +L A   +RR  L++ ++  + + 
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508

Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
            +L            +W+      L    + H+ E  Q L    E  K  L
Sbjct: 509  QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)

Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
            LE   + LQ+ +     P +  S+  +   +    G L+QV+    E +    RR +   
Sbjct: 334  LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393

Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               + F Q++     W +  +A LR K+  +  ++  + LL++H+    ++   Q+R++Q
Sbjct: 394  HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
            + A +Q +  LD  DS  V    + +  Q   L  L ++R++ L+     +K    +D  
Sbjct: 454  IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510

Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
                A   A    W+   +++L +      + E   L   H +F   L      R   L 
Sbjct: 511  YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570

Query: 1234 AHGE--KLVQSQH 1244
             H E  K+VQ+ H
Sbjct: 571  IHNEVSKIVQTYH 583



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)

Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
            L   F Q A+  E W       L++         ++K LLK H+AFE+++ AH++ +  +
Sbjct: 395  LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
            A   + L    +  +  V+ R Q +   W++L      R + LE     LE + ++ L  
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 2234 A 2234
            A
Sbjct: 515  A 515



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 330  EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
             + L+   + F       E W   KE  L  +      L+ ++ LL KH+  E DL    
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
             ++  + A A+ L++  + ++ S   RCQ +  + + L      RR  LE   +L
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 41.6 bits (96), Expect = 0.015
 Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)

Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
            AQ  E  A R+ +     +E  Q      +  S LL++ R     + W++ ++P      
Sbjct: 252  AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
              Q L   R  +  H+  + +      +    L T  +L     F   E           
Sbjct: 309  MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
              ++Q+EK          RR   L    E  +    + EA  W   +  +L  +D   + 
Sbjct: 369  GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426

Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
                +ALL++ EA + DL A   R+E++   A  L      +SP V A+ Q + +     
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
             A  +  R A  R   L E +    LE  +     + W+  + A  + QD       +++
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544

Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
            +G+    E+F     DA ++ +  LG      + K+  T         P+       I  
Sbjct: 545  QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602

Query: 3158 AWERLDQAIKARTENLAAAH 3177
             W+ + Q +  R + L   H
Sbjct: 603  KWDHVRQLVPRRDQALTEEH 622



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
            EQ++    +W      +E RR + L  L  ++++Q  +    W + K  M   +   +  
Sbjct: 372  EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426

Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
               I   LK+HEA ES+L A +  VE +  + +EL          +  R Q +  +W+ L
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
                 +R + L++  +  + + QL     + A      +EGA   LQ +     +   Q 
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 1422 LQKRHQQLES 1431
            L   H+Q ++
Sbjct: 547  LTTAHEQFKA 556



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
           L+E+  LL++H+  E+ ++AH   V  +A    EL+         + A+ + +     +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
            AL + RR  LE+T +  E +     E A        W++   + + +  +   + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 642 ALQKHKALEA 651
               H+  +A
Sbjct: 547 LTTAHEQFKA 556



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)

Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
            CL+++E   +E    W L   R  E      +K RQ+    EAW    E +L + DY  +
Sbjct: 370  CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425

Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
             +S+++ LL +H+  E  LAA +++  Q+     E
Sbjct: 426  TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)

Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
            +D R  +RL K  +     QLE    TL  K         M +   M   +  +   LE+
Sbjct: 314  EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373

Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             +K         +RRLE L  HLA             +F   +++  +W           
Sbjct: 374  VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             Y T  L+  ++L +KH+  + ++ AHQ +V+++ +  + L    +  +  +  +CQ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
              W  L    + R + L++      T  Q +L+ ++       W+E
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)

Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
            ++WL  E   L++     + F    + H+AW           D     + E  +LL++H 
Sbjct: 379  EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
             F   L+    R E + A  ++L +  +  + +V  + Q I  QW  L   +++RR  L 
Sbjct: 439  AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498

Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
             + +L         E+ +  A    WME           GA  ++  T   H   E + L
Sbjct: 499  RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547

Query: 1329 AT 1330
             T
Sbjct: 548  TT 549



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)

Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
            R C+  A   +     + Y    S+L  W+    P + +R             ++    R
Sbjct: 261  RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320

Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
             ++K   +QE  +L I ++++    QT   L+     +P + R+V +       L +  +
Sbjct: 321  RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376

Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              +E      R LE    L E  R+   + + W   ++   +  +           L  K
Sbjct: 377  GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
               F+  +     RV     +A+ L E  +   P V  R Q +   W  L  LTQ R  A
Sbjct: 437  HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496

Query: 1798 LRDTETTL 1805
            L  TE  L
Sbjct: 497  LERTEKLL 504



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)

Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
            +  ++D +++A+    W+R + +  LE  + +  M   Q QK ++F+      +H+  ++
Sbjct: 273  EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328

Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
            Q + Q          +L     PA    + R+  ++   WG L+           N  ++
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
            + +L    E  R + S+ E   W +  E  LR      A L  +  LL      E+ +  
Sbjct: 389  LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446

Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
               + E +   AQ      +  +  V  + +++  ++ +L    Q+RR ALE    LL+ 
Sbjct: 447  HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506

Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
                  E A        W++  +          ++  ++ L   H+  ++ +   +    
Sbjct: 507  IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566

Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
             +LG      K+VQ  H              Q++     H+R    RR   L +    Q 
Sbjct: 567  AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626

Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
                   QF  +    G W+  +   +   S +M  + E   + LR+ E   + +  + P
Sbjct: 627  HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683

Query: 3019 RIERLQQTAALLE 3031
            +I++L+    L++
Sbjct: 684  KIDQLEGDHQLIQ 696



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)

Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
            S G MV     D+  AW          E W L + R    L       R    + E  T 
Sbjct: 356  SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411

Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
             +E      +     L  ++A L+ H+  E +L   + +++++   A  + +L     + 
Sbjct: 412  GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470

Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
            +V  R Q +   W  L    ++RR  LER  +LL        +YA       +W     +
Sbjct: 471  SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530

Query: 1930 DLQ 1932
            DLQ
Sbjct: 531  DLQ 533



 Score = 32.3 bits (72), Expect = 8.8
 Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)

Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
            +LER   LA +FR     + +W       L Q +  +   S     L  H+   ++L A 
Sbjct: 388  RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
            +   +Q   + Q+        +  V    + + DQ D +     +++E L+  ++     
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507

Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
            +QL+L    R       +      L+ + +  ++EE++ L   HE F   L   DK+  A
Sbjct: 508  DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567

Query: 2073 L 2073
            +
Sbjct: 568  I 568


>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score =  344 bits (882), Expect = 1e-93
 Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  DG+ L+ LLE+ISGE L  P RG++RVH
Sbjct: 31  KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 89  KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVNI +F  SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            PL NL  AF VAE+ L I ++LD ED V  A+PDE++IMTYVS +YH  S   + +T  
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L   YE+L +DLL WI      LE R   +++ AM+Q L  F  +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R   KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE  E    
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
           + L   + +L+RL+ LA +F+ KA++ E++    E +L Q     A+L+ ++A +++   
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
            E+ +   + R + +A IA  L +  Y+    V  R +++  +W  L    Q +R+ +  
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499

Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
            + +L  + ++       AA  ++ +E   E  + T     + E+  L   H+  +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
            + LE+++R      W++ +  +  +  + Q LE         R++R       V + C  
Sbjct: 285  DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334

Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
             I+  +LQ K R        P E +++    S +NN W         Y++ L    EI  
Sbjct: 335  EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388

Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
            L R LD++ ++ ++K ++ +A   GK+            L  ++ LL+KHE  E ++   
Sbjct: 389  LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
            Q +VE +      L +     +  +  R Q++ + W  L +  QKRREAL+   + +KL 
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504

Query: 2442 AMLQEL 2447
              + +L
Sbjct: 505  ETIDQL 510



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
            Q + +  ++    Q +  L    AF+     +  D+      L Q  K   E L      
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
            LE    L + FR  A    AW   K  +   +DY  + LS ++ L ++H+  ES++++H+
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  ++ +  V AR Q++     +L A   +RR  L++ ++  + + 
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508

Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
            +L            +W+      L    + H+ E  Q L    E  K  L
Sbjct: 509  QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)

Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
            LE   + LQ+ +     P +  S+  +   +    G L+QV+    E +    RR +   
Sbjct: 334  LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393

Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
               + F Q++     W +  +A LR K+  +  ++  + LL++H+    ++   Q+R++Q
Sbjct: 394  HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453

Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
            + A +Q +  LD  DS  V    + +  Q   L  L ++R++ L+     +K    +D  
Sbjct: 454  IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510

Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
                A   A    W+   +++L +      + E   L   H +F   L      R   L 
Sbjct: 511  YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570

Query: 1234 AHGE--KLVQSQH 1244
             H E  K+VQ+ H
Sbjct: 571  IHNEVSKIVQTYH 583



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)

Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
            L   F Q A+  E W       L++         ++K LLK H+AFE+++ AH++ +  +
Sbjct: 395  LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
            A   + L    +  +  V+ R Q +   W++L      R + LE     LE + ++ L  
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 2234 A 2234
            A
Sbjct: 515  A 515



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 330  EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
             + L+   + F       E W   KE  L  +      L+ ++ LL KH+  E DL    
Sbjct: 389  LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
             ++  + A A+ L++  + ++ S   RCQ +  + + L      RR  LE   +L
Sbjct: 449  DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 41.6 bits (96), Expect = 0.015
 Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)

Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
            AQ  E  A R+ +     +E  Q      +  S LL++ R     + W++ ++P      
Sbjct: 252  AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308

Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
              Q L   R  +  H+  + +      +    L T  +L     F   E           
Sbjct: 309  MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368

Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
              ++Q+EK          RR   L    E  +    + EA  W   +  +L  +D   + 
Sbjct: 369  GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426

Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
                +ALL++ EA + DL A   R+E++   A  L      +SP V A+ Q + +     
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
             A  +  R A  R   L E +    LE  +     + W+  + A  + QD       +++
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544

Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
            +G+    E+F     DA ++ +  LG      + K+  T         P+       I  
Sbjct: 545  QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602

Query: 3158 AWERLDQAIKARTENLAAAH 3177
             W+ + Q +  R + L   H
Sbjct: 603  KWDHVRQLVPRRDQALTEEH 622



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
            EQ++    +W      +E RR + L  L  ++++Q  +    W + K  M   +   +  
Sbjct: 372  EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426

Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
               I   LK+HEA ES+L A +  VE +  + +EL          +  R Q +  +W+ L
Sbjct: 427  LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
                 +R + L++  +  + + QL     + A      +EGA   LQ +     +   Q 
Sbjct: 487  GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 1422 LQKRHQQLES 1431
            L   H+Q ++
Sbjct: 547  LTTAHEQFKA 556



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
           L+E+  LL++H+  E+ ++AH   V  +A    EL+         + A+ + +     +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486

Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
            AL + RR  LE+T +  E +     E A        W++   + + +  +   + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546

Query: 642 ALQKHKALEA 651
               H+  +A
Sbjct: 547 LTTAHEQFKA 556



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)

Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
            CL+++E   +E    W L   R  E      +K RQ+    EAW    E +L + DY  +
Sbjct: 370  CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425

Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
             +S+++ LL +H+  E  LAA +++  Q+     E
Sbjct: 426  TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)

Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
            +D R  +RL K  +     QLE    TL  K         M +   M   +  +   LE+
Sbjct: 314  EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373

Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
             +K         +RRLE L  HLA             +F   +++  +W           
Sbjct: 374  VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
             Y T  L+  ++L +KH+  + ++ AHQ +V+++ +  + L    +  +  +  +CQ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
              W  L    + R + L++      T  Q +L+ ++       W+E
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)

Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
            ++WL  E   L++     + F    + H+AW           D     + E  +LL++H 
Sbjct: 379  EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438

Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
             F   L+    R E + A  ++L +  +  + +V  + Q I  QW  L   +++RR  L 
Sbjct: 439  AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498

Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
             + +L         E+ +  A    WME           GA  ++  T   H   E + L
Sbjct: 499  RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547

Query: 1329 AT 1330
             T
Sbjct: 548  TT 549



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)

Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
            R C+  A   +     + Y    S+L  W+    P + +R             ++    R
Sbjct: 261  RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320

Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
             ++K   +QE  +L I ++++    QT   L+     +P + R+V +       L +  +
Sbjct: 321  RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376

Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
              +E      R LE    L E  R+   + + W   ++   +  +           L  K
Sbjct: 377  GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
               F+  +     RV     +A+ L E  +   P V  R Q +   W  L  LTQ R  A
Sbjct: 437  HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496

Query: 1798 LRDTETTL 1805
            L  TE  L
Sbjct: 497  LERTEKLL 504



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)

Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
            +  ++D +++A+    W+R + +  LE  + +  M   Q QK ++F+      +H+  ++
Sbjct: 273  EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328

Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
            Q + Q          +L     PA    + R+  ++   WG L+           N  ++
Sbjct: 329  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388

Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
            + +L    E  R + S+ E   W +  E  LR      A L  +  LL      E+ +  
Sbjct: 389  LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446

Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
               + E +   AQ      +  +  V  + +++  ++ +L    Q+RR ALE    LL+ 
Sbjct: 447  HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506

Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
                  E A        W++  +          ++  ++ L   H+  ++ +   +    
Sbjct: 507  IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566

Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
             +LG      K+VQ  H              Q++     H+R    RR   L +    Q 
Sbjct: 567  AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626

Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
                   QF  +    G W+  +   +   S +M  + E   + LR+ E   + +  + P
Sbjct: 627  HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683

Query: 3019 RIERLQQTAALLE 3031
            +I++L+    L++
Sbjct: 684  KIDQLEGDHQLIQ 696



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)

Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
            S G MV     D+  AW          E W L + R    L       R    + E  T 
Sbjct: 356  SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411

Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
             +E      +     L  ++A L+ H+  E +L   + +++++   A  + +L     + 
Sbjct: 412  GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470

Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
            +V  R Q +   W  L    ++RR  LER  +LL        +YA       +W     +
Sbjct: 471  SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530

Query: 1930 DLQ 1932
            DLQ
Sbjct: 531  DLQ 533



 Score = 32.3 bits (72), Expect = 8.8
 Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)

Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
            +LER   LA +FR     + +W       L Q +  +   S     L  H+   ++L A 
Sbjct: 388  RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447

Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
            +   +Q   + Q+        +  V    + + DQ D +     +++E L+  ++     
Sbjct: 448  QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507

Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
            +QL+L    R       +      L+ + +  ++EE++ L   HE F   L   DK+  A
Sbjct: 508  DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567

Query: 2073 L 2073
            +
Sbjct: 568  I 568


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score =  338 bits (866), Expect = 7e-92
 Identities = 201/533 (37%), Positives = 302/533 (56%), Gaps = 21/533 (3%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           + Q KTFT W N+  +  +AG +I N+  +  DG+ L+ LLE+ISGE LP P RG++RVH
Sbjct: 50  KQQRKTFTAWCNSHLR--KAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVH 107

Query: 79  FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            + N ++AL F+ +K V +  IG E IVDG+  + LG+IW IILRF I  IS+++     
Sbjct: 108 KINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEET---- 163

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
                S KE LL+WCQRKTA Y NVN+ +F  SW DGL FNALIH HRP+L++Y  LR D
Sbjct: 164 -----SAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKD 218

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
            P+ NL  AF VAE+ L I ++LD ED+   A+PDE++IMTYVS +YH  S   + +T  
Sbjct: 219 DPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAA 278

Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
            R+ K+L   QE E L   YE+L +DLL WI      LE R    ++  M+Q L  F  +
Sbjct: 279 NRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDY 338

Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
           R   KPP++Q++   E     LQT L+  NR  F+P EG  +++++  W  LE AE    
Sbjct: 339 RRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE 398

Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
           + L   + +L+RL+ LA +F+ KA++ E++    E +L       A+L+ ++A +++   
Sbjct: 399 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEA 458

Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL--LQH-----LQG 489
            E+ +   + R + +A IA  L +  Y+   +V  R +++  +W  L  L H     L+ 
Sbjct: 459 FESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEK 518

Query: 490 QRKQV-ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
             KQ+ A  Q  L   +     ++ +E   E  +       + E+  L+  HD
Sbjct: 519 TEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD 571



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 63/252 (25%), Positives = 114/252 (45%), Gaps = 38/252 (15%)

Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
            + LE+++R      W++++  +  + ++ Q LE         R++R       V + C  
Sbjct: 304  DLLEWIRRTI---PWLEDRVPQKTIQEMQQKLED-------FRDYRRVHKPPKVQEKCQL 353

Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
             I+  +LQ K R        P E K++    S +NN W         Y++ L    EI  
Sbjct: 354  EINFNTLQTKLRLSNRPAFMPSEGKMV----SDINNGWQHLEQAEKGYEEWLLN--EIRR 407

Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
            L R LD++ ++ ++K ++ +A   GK+            L  ++ L+RKHE  E ++   
Sbjct: 408  LER-LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466

Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
            Q +VE +      L +     +H +  R Q++ + W  L S    RREAL+     ++L+
Sbjct: 467  QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE--KQLE 524

Query: 2442 AMLQELLVSAQR 2453
            A+ Q  L  A+R
Sbjct: 525  AIDQLHLEYAKR 536



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 84/401 (20%), Positives = 160/401 (39%), Gaps = 41/401 (10%)

Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHK------ELQVEVKAHQGQVQRVLSSGRSL 1551
            + W+ + +P  +     + L   +   R HK      + Q+E+  +  Q +  LS+  + 
Sbjct: 313  IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAF 372

Query: 1552 AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL-EGWVEEK 1610
              S       I    Q LE      E       + L++     + F   + + E W + K
Sbjct: 373  MPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGK 432

Query: 1611 RPLVSSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
              ++  RDY   E ATL     LI KH+A + +LA +   +E++   AQ L   +  +  
Sbjct: 433  EAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH 489

Query: 1667 RVVQ--ERLREQLRALQELAATR-------DRELEGTLRLH-EFLREAEDLQGWLASQKQ 1716
             V    +++ +Q  AL  L  +R       +++LE   +LH E+ + A     W+ S  +
Sbjct: 490  NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549

Query: 1717 AAKGGESLG--EDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGH----SAG 1770
              +    +   E+ E  +    +F       +   + + A    A+ + E  H     + 
Sbjct: 550  DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609

Query: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822
            P      Q + + W ++ +L   R HAL + ++  + +  L              +Q K 
Sbjct: 610  PYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM 669

Query: 1823 TSLPNNVARDLCG-LEAQLRSHQGLERELVGTERQLQELLE 1862
              +   ++ ++ G LE QL   +  ER +V  +  L +LLE
Sbjct: 670  EEI-GRISIEMNGTLEDQLSHLKQYERSIVDYKPNL-DLLE 708



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 80/408 (19%), Positives = 154/408 (37%), Gaps = 36/408 (8%)

Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
            Q + +  ++    Q +  L    AF+     +  D+    + L Q  K   E L      
Sbjct: 348  QEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRR 407

Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
            LE    L + FR  A    AW   K  +   +DY  + LS ++ L  +H+  ES++++H+
Sbjct: 408  LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467

Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
                 +     +L +  ++ +H V  R Q++      L +    RR  L++ ++  + + 
Sbjct: 468  DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527

Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATK-------RDLEAF 3016
            +L            +W+      L    + H+ E  + L+   +  K       R+ EA 
Sbjct: 528  QLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAI 587

Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
                +  Q+ A     + +  +P      Q +     ++ +    R H L E+ Q  Q  
Sbjct: 588  LAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE-QSKQQS 646

Query: 3077 RETL---------LLDAWLTTKAATAESQDYGQ-DLEGVKVLEEKFDAFRKEVQSLGQAK 3126
             E L         ++  W+ TK      ++ G+  +E    LE++    ++  +S+   K
Sbjct: 647  NEHLRRQFASQANVVGPWIQTK-----MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYK 701

Query: 3127 --VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
              +  L +    ++        H       I   WE+L   I ART N
Sbjct: 702  PNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTI-ARTIN 748



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 49/276 (17%)

Query: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVR 1206
            Q L+   +  ++WL  E   L++     + F    + H+AW         H D     + 
Sbjct: 388  QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLS 447

Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
            +  +L+++H  F   L+    R E + A  ++L +  +  +H V  + Q I  QW  L  
Sbjct: 448  DIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGS 507

Query: 1267 RSEQRR-------RQLLASLQLQ-EWKQDVAELMQWMEE-----------------KGLM 1301
             +  RR       +QL A  QL  E+ +  A    WME                  +GL+
Sbjct: 508  LTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI 567

Query: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-RLQ 1360
            +AH+          TL   +     +LA  +  + + +     LS    G     T   Q
Sbjct: 568  SAHD------QFKSTLPDADREREAILAIHKEAQRIAESNHIKLS----GSNPYTTVTPQ 617

Query: 1361 GLRSKWEALNRKMTERGDEL--QQAGQQ--EQLLRQ 1392
             + SKWE + + + +R   L  +Q+ QQ  E L RQ
Sbjct: 618  IINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 31/268 (11%)

Query: 1268 SEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGARRNILQTLKRHEAAES 1325
            +E RR + L  L  ++++Q  +    W + K  M  H    +    +I   +++HEA ES
Sbjct: 403  NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFES 461

Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
            +L A +  VE +  + +EL         ++ TR Q +  +W+AL      R + L++  +
Sbjct: 462  DLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521

Query: 1386 QEQLLRQL---------------QDAKEQL---------EQLEGALQSSETGQD-LRSSQ 1420
            Q + + QL               + A E L         E++EG + + +  +  L  + 
Sbjct: 522  QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581

Query: 1421 RLQKRHQQLESESRTLA-AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGL 1479
            R ++    +  E++ +A +    L+        +P I+    + +++L   + H  +   
Sbjct: 582  REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641

Query: 1480 QLQASVE--LHQFCHLSNMELSWVAEHM 1505
              Q S E    QF   +N+   W+   M
Sbjct: 642  SKQQSNEHLRRQFASQANVVGPWIQTKM 669



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 63/330 (19%), Positives = 139/330 (42%), Gaps = 36/330 (10%)

Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
            + F Q++     W +  +A L+ ++  +  ++  + L+R+H+    ++   Q+R++Q+ A
Sbjct: 416  EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475

Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDGFTA 1187
             +Q +  LD  DS  V    + +  Q   L  L   R++ L++   +L+   +    +  
Sbjct: 476  IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535

Query: 1188 TCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA---HGE 1237
              A    W+   +++L +      + E   L+  H +F   L       EA+ A     +
Sbjct: 536  RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595

Query: 1238 KLVQSQHPAAH------TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE- 1290
            ++ +S H          TV  Q+  I ++W ++Q    +R   LL     Q+  + +   
Sbjct: 596  RIAESNHIKLSGSNPYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653

Query: 1291 -----------LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
                       +   MEE G ++  E +G   + L  LK++E +   ++  + +++ L+Q
Sbjct: 654  FASQANVVGPWIQTKMEEIGRISI-EMNGTLEDQLSHLKQYERS---IVDYKPNLDLLEQ 709

Query: 1340 VGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
              + +        +     ++ +R  WE L
Sbjct: 710  QHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 67/316 (21%), Positives = 130/316 (41%), Gaps = 44/316 (13%)

Query: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS-VEE 2048
            +Q ++ Y+ W     R+ ERL  +   + F ++    E     +E  LK     ++ + +
Sbjct: 391  EQAEKGYEEWLLNEIRRLERL--DHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD 448

Query: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102
            ++ LIRKHE F   L A QD+ E  AA+ + L  L       V  R   +  +   +  L
Sbjct: 449  IKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSL 508

Query: 2103 AESRGHALHAS--------LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154
              SR  AL  +         L   + + A    +W+++  + L++      + +    + 
Sbjct: 509  THSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLIS 568

Query: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAG----EVSQRLQGLRKHWEDLRQ 2207
             H  F++   +     E + ++ K+ + +   +H +        +   Q +   WE ++Q
Sbjct: 569  AHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQ 628

Query: 2208 AMALRGQEL---EDRRNFLEFLQRVDLAEA-----WIQEK-------EVKMNVGDLGQDL 2252
             +  R   L   + ++   E L+R   ++A     WIQ K        ++MN G L   L
Sbjct: 629  LVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMN-GTLEDQL 687

Query: 2253 EHCLQLRRRLREFRGN 2268
             H  Q  R + +++ N
Sbjct: 688  SHLKQYERSIVDYKPN 703



 Score = 42.7 bits (99), Expect = 0.007
 Identities = 45/187 (24%), Positives = 81/187 (43%), Gaps = 5/187 (2%)

Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
            ++C+ E++  T    L  S     + +     SDI      LEQ     E  W  ++++ 
Sbjct: 349  EKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE-EWLLNEIRR 407

Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
             + L+   + F       E W   KE  L         L+ ++ L+ KH+  E DL    
Sbjct: 408  LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467

Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL-RQLQAFL 2653
             ++  + A A+ L++  + ++ +   RCQ +  + +AL     +RR  LE+  +QL+A  
Sbjct: 468  DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527

Query: 2654 QDSQEVA 2660
            Q   E A
Sbjct: 528  QLHLEYA 534



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 50/270 (18%), Positives = 104/270 (38%), Gaps = 32/270 (11%)

Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
           L+++  L+++H+  E+ ++AH   V  +A    EL+         +  + + +     +L
Sbjct: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505

Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
            +L  +RR  LE+T ++ E +     E A        W++   + + +  +   + +I G
Sbjct: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565

Query: 642 ALQKH---KALEAEVHRHQAVCVDLVRRGR--------DLSARRPPTQPDPGERAEAVQG 690
            +  H   K+   +  R +   + + +  +         LS   P T   P    + +  
Sbjct: 566 LISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTP----QIINS 621

Query: 691 GWQLLQTRVVGRGARL--------QTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
            W+ +Q  V  R   L            L  Q+ + A     W++ +   + R S  +  
Sbjct: 622 KWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI-EMN 680

Query: 743 AAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
              E  L    + ER +  +   L  LE+Q
Sbjct: 681 GTLEDQLSHLKQYERSIVDYKPNLDLLEQQ 710



 Score = 39.3 bits (90), Expect = 0.072
 Identities = 39/169 (23%), Positives = 75/169 (44%), Gaps = 12/169 (7%)

Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQ-DLRQEGQQLVDNSH 3350
            + W ++R    + +E+ + +         H+    +  +C+L+   +  Q   +L +   
Sbjct: 313  IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQ-EKCQLEINFNTLQTKLRLSNRPA 371

Query: 3351 FMSAEVTECLQELEGRLQELEEA------WALRWQRCAESWG--LQKLRQRLEQAEAWLA 3402
            FM +E  + + ++    Q LE+A      W L   R  E      +K RQ+    EAW  
Sbjct: 372  FMPSE-GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 430

Query: 3403 CWEGLLLKPDYGHS-VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
              E +L   DY  + +SD++ L+ +H+  E  LAA +++  Q+     E
Sbjct: 431  GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQE 479


>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
            sapiens]
          Length = 678

 Score =  269 bits (687), Expect = 4e-71
 Identities = 184/643 (28%), Positives = 311/643 (48%), Gaps = 11/643 (1%)

Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
            RH+A  +EL   +  +E +++ G++L+  +P     ++ +L  +R  W  L      +  
Sbjct: 21   RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80

Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
            +L +A + +QL++   +  ++L  +E  LQ  + G DL +     K+ Q +ES+      
Sbjct: 81   QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140

Query: 1439 KMAALASMAHGMAASPAILE---ETQKHL-RRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
            ++  L +    +   PA  E   E Q  +  RL  L   L  R   L AS ELHQ  H  
Sbjct: 141  EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
            + EL+WV E +P    T     L   Q   +K++ L+ E++AH  +++ VL    +LA+ 
Sbjct: 201  DDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL 260

Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
              P+A+ +    ++L+  WA L  A E R Q L  A   +QY+ DV+E+E W+ E+  L+
Sbjct: 261  RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320

Query: 1615 SSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVV--QER 1672
             S D G+DE +TL+L+ KH  L++ +  Y  S+ +L +  + L     P+ +++   Q +
Sbjct: 321  MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380

Query: 1673 LREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHAL 1732
            +     AL+EL   R   LE    L++  R+  +L+ W+A +K+   G   LG+D EH  
Sbjct: 381  VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA-EKEVVAGSPELGQDFEHVS 439

Query: 1733 HLCTKFAKFQHQVEM-GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
             L  KF++F  +  M G +R+AA   + + L+E GH+A   + + +  L  AW+EL EL 
Sbjct: 440  VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499

Query: 1792 QARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP--NNVARDLCGLEAQLRSHQGLERE 1849
              R   L  +    +   D  E+  Q++EK   LP             +  R+ +  E +
Sbjct: 500  GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHD 559

Query: 1850 LVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARL 1909
            L     Q+++L E A +++ +  G  A A+  R+Q V Q W  L    E  R  +     
Sbjct: 560  LQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD 619

Query: 1910 LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
              RF + VRD  SW   +   +   +  + PSS  L L A  W
Sbjct: 620  ALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS-LLGLPASPW 661



 Score =  248 bits (632), Expect = 1e-64
 Identities = 177/624 (28%), Positives = 302/624 (48%), Gaps = 7/624 (1%)

Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736
            D   L  +  + Q F AEL  +    ++++REGQ+L+Q     + +++++L E+   W E
Sbjct: 11   DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70

Query: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRE 2796
            L+  +Q K  +L +A +A +L +S  EL+  L  +E +L+    G  L  V   L   + 
Sbjct: 71   LESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS 130

Query: 2797 LEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEA 2856
            +E+ V++  R+   L  Q  A   E     + V E+   + +R   L EPLQERR  L A
Sbjct: 131  MESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189

Query: 2857 RSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRV 2916
               L +   D D+E+AWVQE+LPLA   + G  L AV+   +++Q L  E+ +H      
Sbjct: 190  SKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEE 249

Query: 2917 VLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEA 2976
            VL     L       A  V   ++QL+ A A LR  A RR+ +L  A + +Q+  ++ E 
Sbjct: 250  VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309

Query: 2977 GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNP 3036
             +WL E+  ++ SED G   ++T  LL++    ++ +E +   I +L +    L    +P
Sbjct: 310  EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369

Query: 3037 ESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQ 3096
            +S ++  +   V   +  L    E R   L++Q  L+QL R+   L+ W+  K   A S 
Sbjct: 370  DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429

Query: 3097 DYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIE 3156
            + GQD E V VL+EKF  F  E    G+ ++ A+ ++   L          +   +  + 
Sbjct: 430  ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489

Query: 3157 AAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGEDGGHSLSSVRTL 3215
             AW  L + +  R + LAA+ E+H F   A ELQG+++EK   L +         S  ++
Sbjct: 490  EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549

Query: 3216 QQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQEAWATLQAKAQE 3270
            Q+  R  E +L+ +  +V +LQ  A +L     G+   A      +V + W  L +  ++
Sbjct: 550  QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609

Query: 3271 RGQWLAQAAQGHAFLGRCQELLAW 3294
                ++  A    F  + ++LL+W
Sbjct: 610  ARLHVSSTADALRFHSQVRDLLSW 633



 Score =  150 bits (379), Expect = 2e-35
 Identities = 138/638 (21%), Positives = 282/638 (44%), Gaps = 22/638 (3%)

Query: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMA 2210
            K  L+HQAF AE+  ++E +  + ++G+ L+ +    A  V ++L  +R+ W +L     
Sbjct: 17   KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76

Query: 2211 LRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSA 2270
             + ++L +     + +Q     +  +   E ++   D G DL       ++L+       
Sbjct: 77   AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM----- 131

Query: 2271 GDTVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGA 2328
             ++  +   R + +L  Q      +P   +++ +R++ +  R       L   ++ L  +
Sbjct: 132  -ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLAS 190

Query: 2329 LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
             E+H ++ +LD+    +QE+  L    + G  L++VQ+ ++K++ L RE+     ++E +
Sbjct: 191  KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250

Query: 2389 EREVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
                G L   RSPE A  +R   +++  +W  LR  A++R++ LDA  Q ++    + E+
Sbjct: 251  LERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309

Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
                      M +    +      ++L++H + +  ++++ +SI+      + LL  GHP
Sbjct: 310  EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369

Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
             S  I +  + +++   +L+   +E ++ L+Q   L      V ++E W+  KE    S 
Sbjct: 370  DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429

Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQA 2624
             L      +  L  + K  E+  E   AG  +++A+      L + GH  A +       
Sbjct: 430  ELGQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 487

Query: 2625 MLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTA 2679
            +      L    GTR   L   R+L  F  D++E+   + EK      L    E     +
Sbjct: 488  LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 547

Query: 2680 MLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQD 2739
             +   L+  ++    L + + Q QE   + + +  G H  +EAI  R +E+   W EL  
Sbjct: 548  SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLS 605

Query: 2740 NSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
              +     +    +ALR    + +L +W++ I  ++ A
Sbjct: 606  ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 643



 Score =  130 bits (326), Expect = 3e-29
 Identities = 147/636 (23%), Positives = 268/636 (42%), Gaps = 25/636 (3%)

Query: 2359 KDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWW 2418
            +D   + +   +H+    E+   +  +E +ERE  +L Q  PE A  +R +  E+ + W 
Sbjct: 10   EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69

Query: 2419 QLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ 2478
            +L S  Q +   L    +A +L     EL      + +Q+               L++ Q
Sbjct: 70   ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129

Query: 2479 ECKAELDSWTDSISLARSTGQ-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEH 2533
              +++++ W       R  G+ Q  TA  P     ++++      + + L  L    QE 
Sbjct: 130  SMESQVEEW------YREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183

Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQ 2593
            +  L  + EL      ++    W+  +          + L  ++  + K++ L  +++  
Sbjct: 184  RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243

Query: 2594 AGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAF 2652
              ++  +   A  L     PEA+ A+ R    L    A  R+A  RR + L+   Q++ +
Sbjct: 244  GPRLEEVLERAGALASLRSPEAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302

Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQ 2710
              D  EV AWL E+ L+ + E          QL K ++ Q E     +++   +L R+ +
Sbjct: 303  YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCR 361

Query: 2711 RLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
             LL+ GHP SE I  R  ++  L+  L++  +++   L++     +L R + ELE+W+  
Sbjct: 362  ALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAE 421

Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDV 2829
             EV   +P +GQ    V  L     E  +      R+  A + Q     +  GH  A  +
Sbjct: 422  KEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481

Query: 2830 EEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQD 2885
             E    L + +  L E +  R   L A   L KFF DA E    ++EK   LP L    +
Sbjct: 482  AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541

Query: 2886 YGQSLSAV-RHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
               S S++ R L+    +L+  +S    L         + V AG   A  +A+R Q++ +
Sbjct: 542  PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQ 598

Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWL 2980
                L +     RL +    +A +F +++ +  SW+
Sbjct: 599  GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634



 Score =  125 bits (314), Expect = 8e-28
 Identities = 142/647 (21%), Positives = 264/647 (40%), Gaps = 31/647 (4%)

Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQ 1258
            D   ED  +      +H+ F   L+      E +   G++L+Q +   A +VR++L  I+
Sbjct: 6    DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65

Query: 1259 AQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-MQWMEEKGLMAAHEPSGARRNILQTL 1317
              W  L+  ++ + RQL  + +  +  Q  AEL  + +  +  +   +P G    +   L
Sbjct: 66   QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125

Query: 1318 KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERG 1377
            K+ ++ ES++    R V  L Q     L   P  +E +  R   +  +   L   + ER 
Sbjct: 126  KKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184

Query: 1378 DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLA 1437
              L  + +  Q+   L D    +++       +E G  L++ Q+  K++Q L  E +   
Sbjct: 185  RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244

Query: 1438 AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA-------IRGLQLQASVELHQF 1490
             ++  +   A  +A+  +   E +   R LE LQ   A        R   L A+ ++ Q+
Sbjct: 245  PRLEEVLERAGALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302

Query: 1491 CHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRS 1550
                    +W+ E           +       L +KH +L+  V+ ++  + ++    R+
Sbjct: 303  YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRA 362

Query: 1551 LAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEK 1610
            L   GHP ++ I  +  +++  +  L+   E R   L+Q     Q    VSELE W+ EK
Sbjct: 363  LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422

Query: 1611 RPLVSSRDYGRDEAATLRLINKH--------QALQEELAIYWSSMEELDQTAQTLTGPEV 1662
              +  S + G+D      L  K          A +E LA     ++EL +   T      
Sbjct: 423  EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA--- 479

Query: 1663 PEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
                   ++ L E    L EL  TR + L  +  LH+F  +A +LQG +  +++      
Sbjct: 480  --TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537

Query: 1723 SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE-RGHSAG---PMVRQRQQ 1778
            +  E    A  +      F+H +++    V+  R L E   + R   AG     +  R+Q
Sbjct: 538  TPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQ 594

Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
            ++   W EL    +     +  T   LR H  + ++L+ +   A+ +
Sbjct: 595  EVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQI 641



 Score =  123 bits (309), Expect = 3e-27
 Identities = 133/597 (22%), Positives = 248/597 (41%), Gaps = 40/597 (6%)

Query: 899  LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958
            L+++ F+  LA  K    ++    +QL Q  P  +  ++++  E+ Q W +LE+  + KA
Sbjct: 20   LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79

Query: 959  VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018
             QL  + +    +Q       +L  +  QL+ + PG    T ++             ++ 
Sbjct: 80   RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS-------------QLK 126

Query: 1019 FLQSVVVKVEEPGYAESQPLQGQVETL------QGLLKQVQEQVAQRARRQAET-QARQS 1071
             LQS+  +VEE  Y E   LQ Q   L      + L+ + Q  V +R  R  E  Q R+ 
Sbjct: 127  KLQSMESQVEE-WYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 185

Query: 1072 FLQESQQL----------LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQE 1121
             L  S++L          L W +         E    + + Q+ ++++Q L  EI     
Sbjct: 186  LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 245

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGRE 1181
            RL+++  ++  +A+L  P+++ V   L  L      L+   E+RQQ L    +++++  +
Sbjct: 246  RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 305

Query: 1182 VDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ 1241
            V    A     +  +  ++ G+D +  L LL++H +  + +         L      L++
Sbjct: 306  VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 365

Query: 1242 SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLM 1301
              HP +  +  +   +   +  L+   E+RR  L     L +  + V+EL  W+ EK ++
Sbjct: 366  MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425

Query: 1302 AAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRL 1359
            A     G     +  L  K  E A    +A R  + A+ Q+  EL+    CG     T  
Sbjct: 426  AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIE---CGHTAAATMA 482

Query: 1360 Q---GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDL 1416
            +   GL   W  L   M  R   L  + +  +     ++ + Q+E+    L    T  + 
Sbjct: 483  EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEP 542

Query: 1417 R-SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQG 1472
            R S+  +Q+  +  E + + L +++  L   A  +    A         R  E+LQG
Sbjct: 543  RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599



 Score =  122 bits (307), Expect = 5e-27
 Identities = 145/688 (21%), Positives = 264/688 (38%), Gaps = 85/688 (12%)

Query: 458  LRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEEL 517
            L QE+    A V ++  E+   W  L    Q + +Q+ +      L+Q       +L  +
Sbjct: 46   LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 105

Query: 518  QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA 577
            +   +    G  LA V   L++   +E+QV      V  L  QTA L      S E++  
Sbjct: 106  ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGE 164

Query: 578  KARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLS 637
            +   + +    L+  ++ RR LL  + +  +   + ++E AW++E          G  L 
Sbjct: 165  RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224

Query: 638  QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQT 697
             +   ++K++ L  E+  H     +++ R   L++ R P         E +Q  W  L+ 
Sbjct: 225  AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284

Query: 698  RVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLER 757
                R   L  A  V QY+ D AE  +WL E+   +     G+D+ +   LL++H++LE+
Sbjct: 285  AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344

Query: 758  VLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKM 817
             +  +   + +L  Q RA                                HP        
Sbjct: 345  GVENYEESIAQLSRQCRALLEMG---------------------------HP-------- 369

Query: 818  ALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL 877
                      D   I + Q  + + Y +L+ L + RR  LE+   L+       EL+ W+
Sbjct: 370  ----------DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419

Query: 878  EKQTVLL--QRVQPQADTLEVMQLKYENFLTALAV-GKGLWAEVSSSAEQLRQRYPGNST 934
             ++ V+     +    + + V+Q K+  F +   + G+   A V+   ++L +     + 
Sbjct: 420  AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479

Query: 935  QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL-QP 993
             +   ++ L++ W +L  L   +A  LA S E+  F  +    Q Q+ +   +L  L  P
Sbjct: 480  TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539

Query: 994  GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQ 1053
                 +  ++Q        L    H LQ +V +V                      +Q+Q
Sbjct: 540  PEPRPSASSMQ------RTLRAFEHDLQLLVSQV----------------------RQLQ 571

Query: 1054 EQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLL 1113
            E  AQ     A   A     +E + L  W E + A    ++  + V+S    LR H  + 
Sbjct: 572  EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA---CEDARLHVSSTADALRFHSQVR 628

Query: 1114 EEIHLWQERLQQLDAQSQPMAALDCPDS 1141
            + +        Q+ A  +P     CP S
Sbjct: 629  DLLSWMDGIASQIGAADKPR----CPSS 652



 Score =  111 bits (278), Expect = 1e-23
 Identities = 124/582 (21%), Positives = 245/582 (42%), Gaps = 29/582 (4%)

Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE---EMAWVQE 2876
            REG  L Q+  E A  + ++   +R+   E  +  +A++  L     AD+     A + +
Sbjct: 41   REGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDK 100

Query: 2877 KLPLAAAQ----DYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFA 2931
            KL    +Q    D G  L+ V    ++ Q++ES++   +  +  +   T    ++    +
Sbjct: 101  KLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--S 158

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
               V  R   + + +  L      RR LL  ++E  Q   +L +  +W+ ER  +    +
Sbjct: 159  KELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTE 218

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
             G+  +A Q  +++ +  +R+++A  PR+E + + A  L S ++PE+  V   L+ ++ A
Sbjct: 219  RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSA 278

Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
             A L   AE R   L    Q+ Q   +   ++AWL  +     S+D G+D +    L +K
Sbjct: 279  WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338

Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
                 + V++  ++     R+    LE G P     I  ++S+++  +  L +  + R  
Sbjct: 339  HLQLEQGVENYEESIAQLSRQCRALLEMGHPDS-EQISRRQSQVDRLYVALKELGEERRV 397

Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
             L   + ++   +  +EL+  + EK  +    + G     V  LQ++      E     +
Sbjct: 398  ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGR 457

Query: 3232 E-VARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWLAQAAQGHAFLG 3286
            E +A +      L +    A   +A+    + EAWA L      R Q LA + + H F  
Sbjct: 458  ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517

Query: 3287 RCQELLAWAQERQ----ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
              +EL    +E++     L +  E     +  ++ L   E    +++    Q + L++  
Sbjct: 518  DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFE---HDLQLLVSQVRQLQEGA 574

Query: 3343 QQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAES 3384
             QL       +    E  + +  R QE+ + W      C ++
Sbjct: 575  AQL------RTVYAGEHAEAIASREQEVLQGWKELLSACEDA 610



 Score =  100 bits (250), Expect = 2e-20
 Identities = 146/627 (23%), Positives = 264/627 (42%), Gaps = 35/627 (5%)

Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---RD 1688
            +HQA   ELA     +E++++  Q L   E PE    V+++L E  +   EL +T   + 
Sbjct: 21   RHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79

Query: 1689 RELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMG 1748
            R+L    +  + ++   +L   L   +   +  +  G D         K    + QVE  
Sbjct: 80   RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEW 138

Query: 1749 SQRVAACRLLAESL-LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
             + V   +    +L LE   ++  +V +RQ  +      L E  Q R   L  ++   +V
Sbjct: 139  YREVGELQAQTAALPLEP--ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196

Query: 1808 HRDLLEVLTQVQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
              DL + L  VQE+   ++       L  ++  ++ +QGL RE+     +L+E+LE AG 
Sbjct: 197  AHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA 256

Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
            +  L   P+A AV++  + +  AWA L+   E+R+  L+ A  + ++   V +  +W   
Sbjct: 257  LASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315

Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQ--ALLAAGTPTKE 1984
                +  E+  ++  S    L  H  L   +E  E   +   QL +Q  ALL  G P   
Sbjct: 316  QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD-- 370

Query: 1985 VQEELRALQDQRDQVYQTWAR--KQERLQAEQQEQLF--LRECGRLEEILAAQEVSLKTS 2040
              E++   Q Q D++Y       ++ R+  EQQ  L+   R+   LE  +A +EV   + 
Sbjct: 371  -SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429

Query: 2041 ALGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTL------RRPRVRDRLPILL 2093
             LG   E V  L  K   F  +   A  ++ AA+ + +  L          + +    L 
Sbjct: 430  ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489

Query: 2094 QRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
            +    + EL  +R   L AS  +  F   A + +  I+   ++L     P + R     +
Sbjct: 490  EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549

Query: 2154 LKH-QAFEAEVQ---AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM 2209
             +  +AFE ++Q   +    +   A +   + A  H  A  ++ R Q + + W++L  A 
Sbjct: 550  QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA--IASREQEVLQGWKELLSAC 607

Query: 2210 ALRGQELEDRRNFLEFLQRVDLAEAWI 2236
                  +    + L F  +V    +W+
Sbjct: 608  EDARLHVSSTADALRFHSQVRDLLSWM 634



 Score = 98.6 bits (244), Expect = 1e-19
 Identities = 144/651 (22%), Positives = 254/651 (39%), Gaps = 91/651 (13%)

Query: 358 LAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH---KAALRESFLKDAEQVL 414
           L E+ QCWA LE    + +QA  ++L +  + + L + F     K    ES L+D +   
Sbjct: 61  LGEIRQCWAELE----STTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD--- 113

Query: 415 DQARAPPASLATVEAAVQRLGMLEAGI---LPQEGRFQALAEIADILRQEQYHSWADVAR 471
                P   LATV + +++L  +E+ +     + G  QA      +    +  S   V  
Sbjct: 114 -----PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL----EPASKELVGE 164

Query: 472 RQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLA 531
           RQ  V  R  RLL+ LQ +R+ +   + +  +  +++     ++E    A  T  G  L 
Sbjct: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224

Query: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVA 591
            V + ++++  L  ++ AHG  +  + ++   L S      E ++   R L QLQ +   
Sbjct: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR---RGLEQLQSAWAG 281

Query: 592 LVRA---RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKA 648
           L  A   R+ +L+   Q  ++  +  E EAWL E    + +   G+D       L+KH  
Sbjct: 282 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341

Query: 649 LEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQT 708
           LE  V  ++     L R+ R L     P       R   V   +  L+     R   L+ 
Sbjct: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401

Query: 709 ALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVR-LERVLRAFAAELR 767
              + Q     +E   W+ E+         GQD          HV  L+     FA+E  
Sbjct: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD--------FEHVSVLQEKFSEFASE-- 451

Query: 768 RLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDF 827
                    + R  L  VN  +    + L   G  + A                      
Sbjct: 452 ------TGMAGRERLAAVNQMV----DELIECGHTAAA---------------------- 479

Query: 828 DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRV 887
              T+ + +D L++ +  L  L   R   L  +  L  F S   ELQ  +E++   L R+
Sbjct: 480 ---TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536

Query: 888 ------QPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-IQRQQ 940
                 +P A +++     +E+ L  L        ++   A QLR  Y G   + I  ++
Sbjct: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLV---SQVRQLQEGAAQLRTVYAGEHAEAIASRE 593

Query: 941 EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL 991
           +E+ Q W +L +   +  + ++ + +   F         Q+RD+L  ++ +
Sbjct: 594 QEVLQGWKELLSACEDARLHVSSTADALRF-------HSQVRDLLSWMDGI 637



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 101/450 (22%), Positives = 191/450 (42%), Gaps = 8/450 (1%)

Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
            R +A   +L      +E++++    L   K   +  V  +L  +R+  AEL    +A+  
Sbjct: 21   RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80

Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
             L E  +  QL +    LD  L    +  +  D G DL  V    +K  +   +V+   +
Sbjct: 81   QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140

Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
             +V  L+     L    P     +  +++ +     RL + ++ R   L A+ E+H    
Sbjct: 141  -EVGELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198

Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLG 3244
               +    +QE+  L    + G+ L +V+   ++++ L RE++A    +  +   A  L 
Sbjct: 199  DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258

Query: 3245 QLHP----AAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
             L      A   GL ++Q AWA L+  A+ R Q L  A Q   +     E+ AW  E++ 
Sbjct: 259  SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318

Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
            L  SE+  +D     QLL +H +L Q +         L ++ + L++  H  S +++   
Sbjct: 319  LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378

Query: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
             +++     L+E    R     + + L +L +++ + E W+A  E +   P+ G     V
Sbjct: 379  SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438

Query: 3421 ELLLHRHQDL--EKLLAAQEEKFAQMQKTE 3448
             +L  +  +   E  +A +E   A  Q  +
Sbjct: 439  SVLQEKFSEFASETGMAGRERLAAVNQMVD 468



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 134/655 (20%), Positives = 267/655 (40%), Gaps = 46/655 (7%)

Query: 2055 KHEVFLKVLTAQDKK--EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRG 2107
            +H+ F+  L AQ+K+  E   RE  + ++        VR +L  + Q    ++   +++ 
Sbjct: 21   RHQAFMAEL-AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79

Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHE 2167
              L  +       Q+  + +  +     QL++  P GDL      L K Q+ E++V+   
Sbjct: 80   RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139

Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL---- 2223
              +  +  +  AL  +        S+ L G R++    R    L  + L++RR  L    
Sbjct: 140  REVGELQAQTAALPLEP------ASKELVGERQNAVGERLVRLL--EPLQERRRLLLASK 191

Query: 2224 ---EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
               +    +D   AW+QE+       + G  L+    +++ +++ +G           + 
Sbjct: 192  ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ---AVQQHIKKNQGLRREIQAHGPRLE 248

Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
             + + +  L +    E + + +   QL + WA       R QQ L+ A ++     ++  
Sbjct: 249  EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308

Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
            V   + E+E L+ + D GKD +S  +LL+KH +LE+ V   +  +  L R+   L +   
Sbjct: 309  VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368

Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL--LVSAQRLRAQM 2458
              +  +  RQ +V   +  L+   ++RR AL+  +   +L   + EL   ++ + + A  
Sbjct: 369  PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA-- 426

Query: 2459 DTSPAPRSPVEARRMLEE-HQECKAELD-SWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
              SP      E   +L+E   E  +E   +  + ++       +L+  GH  ++ + +  
Sbjct: 427  -GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485

Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPM 2576
             GL +  + L          L  + EL  F S   +++  +  K   L    L  P  P 
Sbjct: 486  DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR--LTTPPEPR 543

Query: 2577 EPLLWKHKML---EWDLEVQAGKISALE---ATARGLHQGGHPEAQSALGRCQAMLLRKE 2630
                   + L   E DL++   ++  L+   A  R ++ G H EA ++  R Q +L   +
Sbjct: 544  PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS--REQEVLQGWK 601

Query: 2631 ALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
             L       R  +        F    +++ +W+   + +A + G  D    P+ L
Sbjct: 602  ELLSACEDARLHVSSTADALRFHSQVRDLLSWM---DGIASQIGAADKPRCPSSL 653



 Score = 59.3 bits (142), Expect = 7e-08
 Identities = 121/605 (20%), Positives = 233/605 (38%), Gaps = 77/605 (12%)

Query: 550  HGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-- 607
            H A ++ LAQ    L+       +++Q K    A +++ L   +R   A LE T Q    
Sbjct: 22   HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL-GEIRQCWAELESTTQAKAR 80

Query: 608  ---------EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
                     + +++  E +  L     ++ +   G DL+ +   L+K +++E++V     
Sbjct: 81   QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140

Query: 659  VCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
               +L  +   L    P ++   GER  AV      L   +  R   L  +  + Q   D
Sbjct: 141  EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199

Query: 719  AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
              +  +W++ER     +   G    A +  ++++  L R ++A      RLEE    A A
Sbjct: 200  LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP---RLEEVLERAGA 256

Query: 779  RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
             ASL       SP  E++R                                    +  + 
Sbjct: 257  LASL------RSPEAEAVR------------------------------------RGLEQ 274

Query: 839  LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQ 898
            L   +  LR  A+ R+  L+ A  +  +     E++ WL +Q +L+       D    +Q
Sbjct: 275  LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334

Query: 899  L--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
            L  K+      +   +   A++S     L +    +S QI R+Q ++ + +  L+ L  E
Sbjct: 335  LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394

Query: 957  KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------ 1010
            + V L     +    ++    +  + +   ++ A  P   +D  H   L +K +      
Sbjct: 395  RRVALEQQYWLYQLSRQVSELEHWIAE--KEVVAGSPELGQDFEHVSVLQEKFSEFASET 452

Query: 1011 -LVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR 1069
             +    R+  +  +V ++ E G+  +  +    + L     ++ E +  RA+  A ++  
Sbjct: 453  GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512

Query: 1070 QSFLQESQQLLLWAESVQAQL----RSKEVSVDVASAQRLLR--EH--QDLLEEIHLWQE 1121
              F  ++++L    E  + +L       E     +S QR LR  EH  Q L+ ++   QE
Sbjct: 513  HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572

Query: 1122 RLQQL 1126
               QL
Sbjct: 573  GAAQL 577



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 106/492 (21%), Positives = 192/492 (39%), Gaps = 46/492 (9%)

Query: 255 VQRRLTKILLQLQETE---LLQTQYEQLVADL---LRWIAEKQMQLEARDFPDSLPAMRQ 308
           V  RL ++L  LQE     L   +  Q+  DL   L W+ E+       +  + L A++Q
Sbjct: 169 VGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228

Query: 309 LLAAFTIFRT--QEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366
            +      R   Q   PRL++       L  L++      RR        GL +L   WA
Sbjct: 229 HIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSAWA 280

Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPAS 423
           GL  A   R Q L               ++    A  E++L + E ++   D+ +   ++
Sbjct: 281 GLREAAERRQQVLDAAF--------QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQST 332

Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
           L  ++  +Q    LE G+   E     L+     L +  +     ++RRQ +V  R    
Sbjct: 333 LQLLKKHLQ----LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVD-RLYVA 387

Query: 484 LQHLQGQRKQVADMQAVL-SLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDL 542
           L+ L  +R+   + Q  L  L ++V    H + E +  A S   GQ    V  L ++   
Sbjct: 388 LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSE 447

Query: 543 LEAQVSAHG-AHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLE 601
             ++    G   ++ + Q   EL     T+   +      L +    L+ L+  R  LL 
Sbjct: 448 FASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLA 507

Query: 602 QTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661
            + +  +F  +  E +  ++E  +R+       +    A ++Q  + L A  H  Q + V
Sbjct: 508 ASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ--RTLRAFEHDLQ-LLV 564

Query: 662 DLVRRGRDLSARRPPTQPDPGERAEAVQG-------GWQLLQTRVVGRGARLQTALLVLQ 714
             VR+ ++ +A+        GE AEA+         GW+ L +        + +    L+
Sbjct: 565 SQVRQLQEGAAQLRTVY--AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622

Query: 715 YFADAAEAASWL 726
           + +   +  SW+
Sbjct: 623 FHSQVRDLLSWM 634



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 132/674 (19%), Positives = 236/674 (35%), Gaps = 81/674 (12%)

Query: 645  KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGA 704
            +H+A  AE+ +++     + R G+ L   +P       ++   ++  W  L++    +  
Sbjct: 21   RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80

Query: 705  RLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAA 764
            +L  A    Q     AE    L    S L+    G D A   + L++   +E  +  +  
Sbjct: 81   QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140

Query: 765  ELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPD 824
            E+  L+ Q                                             ALP EP 
Sbjct: 141  EVGELQAQ-------------------------------------------TAALPLEP- 156

Query: 825  PDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL 884
                   + + Q+ + +    L    Q RR  L  +  L        +   W++++  L 
Sbjct: 157  --ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLA 214

Query: 885  QRVQPQADTLEVMQ---LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQE 941
             + + + + L+ +Q    K +     +        EV   A  L       +  ++R  E
Sbjct: 215  MQTE-RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLE 273

Query: 942  ELSQRWGQLE--ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDT 999
            +L   W  L   A +R++ +  A  VE   F  +    +  L +  L + +   G  E +
Sbjct: 274  QLQSAWAGLREAAERRQQVLDAAFQVEQYYF--DVAEVEAWLGEQELLMMSEDKGKDEQS 331

Query: 1000 CHALQLAQKKTLVLERRVHFLQSVVVKVE-------EPGYAESQPL---QGQVETLQGLL 1049
               LQL  KK L LE+ V   +  + ++        E G+ +S+ +   Q QV+ L   L
Sbjct: 332  --TLQLL-KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388

Query: 1050 KQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREH 1109
            K++ E+  +R   + +    Q   Q S +L  W    +    S E+  D      L  + 
Sbjct: 389  KELGEE--RRVALEQQYWLYQLSRQVS-ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 445

Query: 1110 QDLLEEIHL-WQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQW 1168
             +   E  +  +ERL  ++     +       +  +      L +   EL  L   R Q 
Sbjct: 446  SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 505

Query: 1169 LQEGLELQKF---GREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTL 1225
            L    EL KF    RE+ G        +    L    E    A S+ +  R F   L  L
Sbjct: 506  LAASRELHKFFSDARELQGQIE--EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLL 563

Query: 1226 GPRAEALRAHGEKL---VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQ 1282
              +   L+    +L      +H  A   RE  Q +   W  L    E  R  + ++    
Sbjct: 564  VSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQGWKELLSACEDARLHVSSTADAL 621

Query: 1283 EWKQDVAELMQWME 1296
             +   V +L+ WM+
Sbjct: 622  RFHSQVRDLLSWMD 635


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  254 bits (648), Expect = 1e-66
 Identities = 313/1256 (24%), Positives = 509/1256 (40%), Gaps = 163/1256 (12%)

Query: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
            ++Q+KT TKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 175  RVQKKTSTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 231

Query: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 232  KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 291

Query: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 292  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346

Query: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 406

Query: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 407  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458

Query: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 514

Query: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 515  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQS----DIRLLAAGKVPQRAGE 570

Query: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 571  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 630

Query: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 631  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 689

Query: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 690  SHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 749

Query: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 750  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 809

Query: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 810  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 869

Query: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 870  QLQKLQEALRRKNSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 921

Query: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 922  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 981

Query: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 982  AAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1041

Query: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 1042 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1098

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 1099 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1133

Query: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 1134 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1192

Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1193 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1252

Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1253 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1312

Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+
Sbjct: 1313 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 188/885 (21%), Positives = 331/885 (37%), Gaps = 136/885 (15%)

Query: 1455 AILEETQKHLR----RLELLQGHLAIRGLQLQASV---ELHQFCHLSNMELSWVAEHMPH 1507
            AILE  +K LR    RLE LQ    +  LQ++A +   +LHQ   L   ++  +A     
Sbjct: 509  AILER-EKQLRSEFERLECLQR--IVTKLQMEAGLCEEQLHQADALLQSDIRLLA----- 560

Query: 1508 GSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQ 1567
                        A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +  
Sbjct: 561  ------------AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY 608

Query: 1568 ELEGHWAELERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEK 1610
             L      +      R            AQ   Q+V  +    D     + +L  WVEE 
Sbjct: 609  RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN 668

Query: 1611 RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ 1670
            +  V   ++G D  +    +  H+ L + +  + + +E        L+ P      R   
Sbjct: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS-PATRGAYRDCL 727

Query: 1671 ERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEH 1730
             RL  Q   L   +  R R LE    LH F+  A     WL ++K+  + G    +   +
Sbjct: 728  GRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTN 783

Query: 1731 ALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWEL 1790
                   ++    ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L
Sbjct: 784  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 843

Query: 1791 TQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD----LCGLEAQLRSHQGL 1846
                   L++     +   D+ E   Q+Q+   +L    + D    +  LE  L+  Q  
Sbjct: 844  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDE 903

Query: 1847 ERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR----------QQAVT--------- 1887
            + +L   +  L  L + A  V +L P   AH ++ R          Q  VT         
Sbjct: 904  KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 963

Query: 1888 ------QAWAVL-------------------QRRMEQRRAQLER-----ARLLARFRTAV 1917
                    W VL                    + +++   +LE        L  +    +
Sbjct: 964  VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDM 1023

Query: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLW----QQATQLGQQ 1973
            +   +W + +R+D+Q+  S    +   LK    +     LE   + +    Q A   G +
Sbjct: 1024 KSLLAWQS-LRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 1082

Query: 1974 ALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLREC-----GRLEE 2028
              L A           + L    +Q  Q  +R Q  +   +  +L L  C      RL  
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1142

Query: 2029 IL---AAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
             L    A+E + + +    +  EVE L +     +  L+A+ +K  AL E   +   P +
Sbjct: 1143 PLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEAEKVLALPE--PSPAAPTL 1196

Query: 2086 RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPG 2144
            R  L + L +  +V+ L+      L    L+   TQ    AE+ ++A  +QLKE    P 
Sbjct: 1197 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG---AEEVLRAHEEQLKEAQAVPA 1253

Query: 2145 DL--RDKLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAGEVS---QR 2194
             L   +  K  LK    +AE Q     A  + +    + GE L  +   R  EV    +R
Sbjct: 1254 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1313

Query: 2195 LQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQE 2238
            +  L + W+ +     +R +ELE   R    + +  D   AW+Q+
Sbjct: 1314 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358



 Score = 63.5 bits (153), Expect = 4e-09
 Identities = 101/434 (23%), Positives = 169/434 (38%), Gaps = 33/434 (7%)

Query: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQR 1271
            L   +E+G+L   +  R + LR+  E+L            E LQ I  +     G  E++
Sbjct: 497  LDVEKEWGKLHVAILEREKQLRSEFERL------------ECLQRIVTKLQMEAGLCEEQ 544

Query: 1272 RRQLLASLQLQEWKQDVAELMQWMEE--KGLMAAHEPSGARRNILQTLK--RHEAAESEL 1327
              Q  A LQ         ++ Q   E  + L  A        N +QTLK  RH   E   
Sbjct: 545  LHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMY 604

Query: 1328 LATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387
                R  E L  +  E   R   G     T++         +  +  +R  EL+     +
Sbjct: 605  RRVYRLHERLVAIRTEYNLRLKAGVAAPATQVA-------QVTLQSVQRRPELE-----D 652

Query: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447
              LR LQD    +E+ +  +  +E G DL S +     H+ L        AK+    S  
Sbjct: 653  STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDE 712

Query: 1448 HGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLSNMELSWVAEHMP 1506
              +  SPA     +  L RL+L    L         S+E LH F   +  EL W+ E   
Sbjct: 713  GQL--SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770

Query: 1507 HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQC 1566
                  +++      +    +  L  E++  + +++ + ++G  L    HP A+  VE  
Sbjct: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP-ARPTVESF 829

Query: 1567 QE-LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAA 1625
            Q  L+  W+ + + C      L++   + Q+F DV E EG +++ +  +  ++     A 
Sbjct: 830  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889

Query: 1626 TLRLINKHQALQEE 1639
              RL +  Q  Q+E
Sbjct: 890  VTRLEDLLQDAQDE 903



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 215/1011 (21%), Positives = 362/1011 (35%), Gaps = 206/1011 (20%)

Query: 463  YHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQ-EVEAASHQLEE----L 517
            YH   DV +   ++ V      + L+ + +++  +Q +++ LQ E      QL +    L
Sbjct: 494  YHP-LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL 552

Query: 518  QEPARSTACG---QQLAEVVELLQRHDLL------EAQVSAHGAH---------VSHLAQ 559
            Q   R  A G   Q+  EV   L + D +      + Q    G H         V  L +
Sbjct: 553  QSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 612

Query: 560  QTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAW 619
            +   + +     ++   A   T  Q+ Q  +  V+ R  L + TL      R  ++  AW
Sbjct: 613  RLVAIRTEYNLRLKAGVAAPAT--QVAQVTLQSVQRRPELEDSTL------RYLQDLLAW 664

Query: 620  LKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQP 679
            ++E   RV  A  G DL  +   L  H+ L   +   QA     + R R           
Sbjct: 665  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAK----IERARS---------- 710

Query: 680  DPGERAEAVQGGWQ-------LLQTRVVGRG-ARLQTALLVLQYFADAAEAASWLRERRS 731
            D G+ + A +G ++       L   +++    ARL++   +  + A A +   WL E+  
Sbjct: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK-- 768

Query: 732  SLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
              E    G D +       R+  +     +++A +R LE + +                 
Sbjct: 769  --EEEEVGFDWSD------RNTNMTAKKESYSALMRELELKEKKI--------------- 805

Query: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
              + L+N G       HP           A P       T+   Q  L   +  +  L  
Sbjct: 806  --KELQNAGDRLLREDHP-----------ARP-------TVESFQAALQTQWSWMLQLCC 845

Query: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
               A L+E  A F F S   E +  L+K    L+R      +  V +L            
Sbjct: 846  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRL------------ 893

Query: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL-KREKAV-QL-----AHS 964
                       E L Q         Q ++E+L++  G L  L KR KAV QL     AH 
Sbjct: 894  -----------EDLLQ-------DAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 935

Query: 965  VEV-CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSV 1023
            +      L  C   QV++         +  G         Q +  K L        + SV
Sbjct: 936  MRGRLPLLAVCDYKQVEV--------TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV 987

Query: 1024 VVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ-RARRQAETQARQSFLQESQQLLLW 1082
               V  P                   ++VQE V +  A+ QA          + + LL W
Sbjct: 988  CFLVPPPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1029

Query: 1083 AESVQAQLRSKEV--SVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140
                Q+  R  ++  S  +A+ + L  E Q   + +H  +   Q     SQ        D
Sbjct: 1030 ----QSLRRDVQLIRSWSLATFRTLKPEEQR--QALHSLELHYQAFLRDSQDAGGFGPED 1083

Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA------TCANHQA 1194
                    R  G      + L +  +Q  QE    Q+   E+           T   H+ 
Sbjct: 1084 RLMAE---REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140

Query: 1195 WLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVRE 1252
             L LD   E  RE    + + ++    +  LG     L A  EK++      PAA T+R 
Sbjct: 1141 RLPLDK--EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198

Query: 1253 QLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS----- 1307
            +L+    +  +++  S     +L     +    Q   E+++  EE+   A   P+     
Sbjct: 1199 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1258

Query: 1308 -GARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-----RLQG 1361
               + ++ +   + EA +    A R  +   Q+VG  L  R   G+ D++      R+  
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH--GERDVEVERWRERVAQ 1316

Query: 1362 LRSKWEALNRKMTERGDELQQAGQQEQLLRQ--------LQDAKEQLEQLE 1404
            L  +W+A+  +   R  EL+Q G+Q +  R+        LQDA+ + EQ++
Sbjct: 1317 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 93/430 (21%), Positives = 164/430 (38%), Gaps = 48/430 (11%)

Query: 2938 RVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAE 2997
            R++ L++ +  L+ EA      L QA    Q    LL AG      G V    D+  +  
Sbjct: 523  RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEV--ERDLDKADS 580

Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLR 3057
              + L   ++  K   +   P+ E++ +    L  R           L A+R  +   L+
Sbjct: 581  MIRLLFNDVQTLK---DGRHPQGEQMYRRVYRLHER-----------LVAIRTEYNLRLK 626

Query: 3058 RAEARGHGLQEQLQLHQLERETLLLD----------AWLTTKAATAESQDYGQDLEGVKV 3107
               A       Q+ L  ++R   L D          AW+       +  ++G DL  V+ 
Sbjct: 627  AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 686

Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
                     + ++   QAK+   R   G L       Y        R++  + +L  + K
Sbjct: 687  QLGSHRGLHQSIEEF-QAKIERARSDEGQLSPATRGAYRDCLG---RLDLQYAKLLNSSK 742

Query: 3168 ARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELE 3227
            AR  +L +   +HSF  AA +    + EK     G D     +++   ++ +  L RELE
Sbjct: 743  ARLRSLES---LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 799

Query: 3228 AMEKEVARLQTEACR-LGQLHPAAP---GGLAKVQEAWA-------TLQAKAQERGQWLA 3276
              EK++  LQ    R L + HPA P      A +Q  W+        ++A  +E   +  
Sbjct: 800  LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 859

Query: 3277 QAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQ 3336
              +      G+ Q+L    QE     +S + +  V   E LL   ++  +++ E +    
Sbjct: 860  FFSDVREAEGQLQKL----QEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 915

Query: 3337 DLRQEGQQLV 3346
             L +  + +V
Sbjct: 916  GLAKRAKAVV 925



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 155/748 (20%), Positives = 282/748 (37%), Gaps = 118/748 (15%)

Query: 2212 RGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ-------LRRRLRE 2264
            R  ELED  + L +LQ  DL  AW++E + +++  + G DL            L + + E
Sbjct: 646  RRPELED--STLRYLQ--DLL-AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEE 700

Query: 2265 F-----RGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
            F     R  S    +  A   +  D    L   D +  K++   +++L +   S H  + 
Sbjct: 701  FQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSL-ESLHSFVA 756

Query: 2320 RYQQQLEGALEIHVLSRELD------NVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
               ++L    E        D      N+T + +   AL++ L+  +  + ++ L    + 
Sbjct: 757  AATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE--KKIKELQNAGDR 814

Query: 2374 LEREVHPIQAQVESLEREVG-------RLC-----QRSPEAAHGLRHRQQEVAESWWQLR 2421
            L RE HP +  VES +  +        +LC          AA+         AE   Q  
Sbjct: 815  LLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL 874

Query: 2422 SRAQKRREALDALHQAQKLQAMLQELLVSAQRL------------RAQMDTSPAPRSPVE 2469
              A +R+ + D      +L+ +LQ+     ++L            RA+      PR P  
Sbjct: 875  QEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934

Query: 2470 ARR----------------MLEEHQECKAELDSWTDSISLARSTGQQLLTAG-----HPF 2508
              R                 + +  EC+    +      +  S+G +           P 
Sbjct: 935  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994

Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
            + ++++ +  LE +  +L   W +  + ++  L  Q     V+ +  W      SLA+  
Sbjct: 995  NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW------SLAT-- 1046

Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPE----AQSALGRC-- 2622
             +  L P E     H +   +L  QA    + +A   G      PE    A+   G C  
Sbjct: 1047 -FRTLKPEEQRQALHSL---ELHYQAFLRDSQDAGGFG------PEDRLMAEREYGSCSH 1096

Query: 2623 --QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAM 2680
              Q +L   E   ++    +  + EL+ ++  L+     A   R  + + L         
Sbjct: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE-----ACETRTVHRLRLPLDKEPARE 1151

Query: 2681 LPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDN 2740
               ++ +QQ  QAE++        L  E +++L    P+  A   R  EL    G+L+  
Sbjct: 1152 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR-SELELTLGKLEQV 1210

Query: 2741 SQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR-APTVGQALPGVGELLGTQRELEA 2799
                   L+K      + R  +  E  L   E +L+ A  V   LP +     + ++L A
Sbjct: 1211 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1270

Query: 2800 AVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE-----EQARRLLQRFKSLREPLQE 2849
              + +    +AL  + +     G  L Q     DVE     E+  +LL+R++++      
Sbjct: 1271 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1330

Query: 2850 RRTALEARSLLLKFFRD-ADEEMAWVQE 2876
            R+  LE     L+++R+ AD   AW+Q+
Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQD 1358



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 185/890 (20%), Positives = 328/890 (36%), Gaps = 141/890 (15%)

Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 477  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 531

Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
             +L + A     Q+  + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 532  TKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 591

Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 592  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 648

Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 649  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 701

Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 702  QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 759

Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 760  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819

Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879

Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 880  RKNSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934

Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 935  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994

Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
             + +QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 995  NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1054

Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 1055 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1114

Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 1115 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1170

Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 1171 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1230

Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1287

Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
                     +++   L++    R   ++  R R+    ER  QA+ A+T+
Sbjct: 1288 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTD 1329



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 69/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470

Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 471  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 526

Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 527  LQRIVTKLQMEAGLCEEQLHQADALLQSDI---RLLAAGKVPQRAGEVERDLDKADSMIR 583

Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 584  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 643

Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E + 
Sbjct: 644  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQA 703

Query: 3334 QAQDLRQEGQQL 3345
            + +  R +  QL
Sbjct: 704  KIERARSDEGQL 715



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 148/781 (18%), Positives = 297/781 (38%), Gaps = 105/781 (13%)

Query: 1802 ETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
            ++TLR  +DLL  + + Q +       V  DL  +EAQL SH+GL + +   + +++   
Sbjct: 652  DSTLRYLQDLLAWVEENQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFQAKIERAR 709

Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYA 1921
               G++     G     + +      +        +   +A+L     L  F  A     
Sbjct: 710  SDEGQLSPATRGAYRDCLGRLDLQYAKL-------LNSSKARLRSLESLHSFVAAATKEL 762

Query: 1922 SWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTP 1981
             W     ++    + S   ++   K  ++  L  ELE +EK  ++    G + L      
Sbjct: 763  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPA 822

Query: 1982 TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK--- 2038
               V+    ALQ Q   + Q     +  L+       F  +    E  L   + +L+   
Sbjct: 823  RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKN 882

Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL--RRPR-----VRDRLPI 2091
            +    ++V  +E L++  +   + L       + L +R K +   +PR     +R RLP+
Sbjct: 883  SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPL 942

Query: 2092 LLQRRMRVKELAESRG---------HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
            L     +  E+   +G            H  +L +S ++AA  +  ++          VP
Sbjct: 943  LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFL----------VP 992

Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRL--QGLRK 2200
            P +                  Q  +E +T +  + +AL+   H    ++   L  Q LR+
Sbjct: 993  PPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRR 1034

Query: 2201 HWEDLR--QAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVG---------DLG 2249
              + +R       R  + E++R  L  L+     +A++++ +     G         + G
Sbjct: 1035 DVQLIRSWSLATFRTLKPEEQRQALHSLEL--HYQAFLRDSQDAGGFGPEDRLMAEREYG 1092

Query: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309
                H  QL + L +    +  ++    CI  + D+ LQL   +  E + + + R  L+ 
Sbjct: 1093 SCSHHYQQLLQSLEQ---GAQEESRCQRCISELKDIRLQL---EACETRTVHRLRLPLDK 1146

Query: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369
              A      +  QQ+ +   E+  L + +  ++   ++  AL +       L S   L  
Sbjct: 1147 EPARECAQRIAEQQKAQA--EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1204

Query: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
               E  R +  I   +E L + +  + + +  A   LR  ++++ E+            +
Sbjct: 1205 GKLEQVRSLSAI--YLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEA------------Q 1249

Query: 2430 ALDA-LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE-----ARRMLEEHQECKAE 2483
            A+ A L + +  +A L++L   A+   AQ  T  A R  +        R+ + H E   E
Sbjct: 1250 AVPATLPELEATKASLKKLRAQAE---AQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1306

Query: 2484 LDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE--GAWQEHQLQLQQAL 2541
            ++ W + ++      Q +L        ++ Q+   L     S +  GAW +   + Q+ +
Sbjct: 1307 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1366

Query: 2542 E 2542
            +
Sbjct: 1367 Q 1367



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 148/715 (20%), Positives = 277/715 (38%), Gaps = 80/715 (11%)

Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   QA++E    + G+L
Sbjct: 656  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL 715

Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR 2455
               SP      R     +   + +L + ++ R  +L++LH    + A  +EL+   ++  
Sbjct: 716  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSF--VAAATKELMWLNEKEE 770

Query: 2456 AQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
             ++    + R+     +  E +     EL+     I   ++ G +LL   HP    +   
Sbjct: 771  EEVGFDWSDRNTNMTAKK-ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 829

Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575
             A L+ + S +       +  L++      F S V + E  L   +++L  +   D  A 
Sbjct: 830  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889

Query: 2576 ---MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKE 2630
               +E LL   +  +  L    G +S L   A+ + Q    HP A    GR   + +   
Sbjct: 890  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCD- 947

Query: 2631 ALFRQAGTRRHRLEELRQLQ----------------------AFL-----QDSQEVAAWL 2663
              ++Q     H+ +E + +                        FL     Q+ QE    L
Sbjct: 948  --YKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005

Query: 2664 REKN--LVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPAS 2720
              ++  LV L   L +D   L A    +++ Q     S+   + L+ E QR  Q  H   
Sbjct: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR--QALHSLE 1063

Query: 2721 ---EAIQERLEELGAL-----------WGELQDNSQKKVAKLQK-ACEALRLRRSMEELE 2765
               +A     ++ G             +G    + Q+ +  L++ A E  R +R + EL+
Sbjct: 1064 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1123

Query: 2766 N---WLEPIEVE----LRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAF 2818
            +    LE  E      LR P   +      + +  Q++ +A V+   +    L  +A+  
Sbjct: 1124 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1183

Query: 2819 VR--EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQE 2876
            +   E    A  +  +    L + + +R         L+  SL+++  + A+E +   +E
Sbjct: 1184 LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1243

Query: 2877 KLPLAAAQDYG-QSLSAVR-HLQEQHQNLESEMSSHEALTRVVLGT---GYKLVQAGHFA 2931
            +L  A A       L A +  L++     E++  + +AL   + G    G +L Q     
Sbjct: 1244 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1303

Query: 2932 AHEVAA---RVQQL-EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
              EV     RV QL E+  A L     R+R L Q  ++ + +       G+WL +
Sbjct: 1304 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 173/785 (22%), Positives = 292/785 (37%), Gaps = 107/785 (13%)

Query: 746  ETLLRRHVRLERVLRAFAAELRRLEEQGRAASA-RASLFTVNSALSPPG------ESLRN 798
            E + RR  RL   L A   E     + G AA A + +  T+ S    P         L++
Sbjct: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660

Query: 799  PGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLE 858
               W E + H   G  W + LP+           L +   L Q  E  +A  ++ RAR +
Sbjct: 661  LLAWVEENQHRVDGAEWGVDLPSV-------EAQLGSHRGLHQSIEEFQA--KIERARSD 711

Query: 859  EAM---ALFGFCSSC-GELQLWLEKQTVLLQRVQPQADTLEVM---------QLKYENFL 905
            E     A  G    C G L L   K   LL   + +  +LE +         +L + N  
Sbjct: 712  EGQLSPATRGAYRDCLGRLDLQYAK---LLNSSKARLRSLESLHSFVAAATKELMWLNEK 768

Query: 906  TALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE--------K 957
                VG   W++ +++    ++ Y     +++ +++++ +     + L RE        +
Sbjct: 769  EEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVE 827

Query: 958  AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017
            + Q A   +    LQ C   +  L++     +        D   A    QK    L R+ 
Sbjct: 828  SFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-----DVREAEGQLQKLQEALRRKN 882

Query: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQ 1077
               +S  V   E    ++Q  + Q+   +G L  +    A+RA+   + + R        
Sbjct: 883  SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL----AKRAKAVVQLKPRHPAHPMRG 938

Query: 1078 QLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALD 1137
            +L L A     Q+   EV+V      +L+   Q      H         +A    +  L 
Sbjct: 939  RLPLLAVCDYKQV---EVTVHKGDECQLVGPAQPS----HWKVLSSSGSEAAVPSVCFLV 991

Query: 1138 CPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLH 1197
             P +QEV   +  L  Q Q L  LW Q    ++  L  Q   R+V    +        L 
Sbjct: 992  PPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK 1051

Query: 1198 LDNLGEDVREALSLLQQHREF----GRLLSTLGP--RAEALRAHG------EKLVQSQHP 1245
                 E+ R+AL  L+ H +      +     GP  R  A R +G      ++L+QS   
Sbjct: 1052 ----PEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1107

Query: 1246 AAHTVR------EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
             A           +L+ I+ Q    + R+  R R  L     +E  Q +AE  +   E +
Sbjct: 1108 GAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVE 1167

Query: 1299 GL-MAAHEPSGARRNILQTLKRHEAA---ESELLATRRHVEALQQVGRELLSRRPCGQED 1354
            GL       S     +L   +   AA    SEL  T   +E ++ +    L +     + 
Sbjct: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK----LKT 1223

Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414
            I   ++G +   E L        ++L++A      L +L+  K  L++L    ++ +   
Sbjct: 1224 ISLVIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1279

Query: 1415 D-----LRSSQ----RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465
            D     LR +Q    RLQ+RH + + E      ++A L      +    A+L +T    R
Sbjct: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTDVRQR 1333

Query: 1466 RLELL 1470
             LE L
Sbjct: 1334 ELEQL 1338


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  222 bits (566), Expect = 5e-57
 Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)

Query: 408  KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
            K+ ++ L++ +A    +++ + AV++L      +L+A   +LP +   Q   +  DI+ +
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2080

Query: 461  EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
             +  S   V  R E++ +   R L    G  + +  M  V S L+E         + Q P
Sbjct: 2081 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2130

Query: 521  ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
              STA       + +++ ++ +LE  ++   + ++ + ++  + ++++  ++   LQAK 
Sbjct: 2131 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2183

Query: 580  RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
            + L+          +   A +E+   + E   N  E+ + +L+   Q +    + G+D++
Sbjct: 2184 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2243

Query: 638  QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
            +++  +Q+  +   E  +H  V   L++   ++S+   P+      E+   +   ++ ++
Sbjct: 2244 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2300

Query: 697  TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
              +  +   + +    L  F    ++  SW++E   + ++    Q    AE L   L   
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2357

Query: 753  VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
             +L+        E++++   G       SL  + SA++ P +++      S  +   G G
Sbjct: 2358 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2409

Query: 813  DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
             A           +F  N    +I +    +S  YE L  L + + A L   ++ L    
Sbjct: 2410 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2462

Query: 868  SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
                 +  WL+K      + Q  P     E ++ + E   +F   L        E+    
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2522

Query: 923  EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
             +L +  P      + +Q   E+  +W +L  L  ++  +L  S    + L +    + Q
Sbjct: 2523 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2579

Query: 981  LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
            L+  L++ E     L P S +      Q  Q + L+ E      Q   +     G   S+
Sbjct: 2580 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2638

Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
            P  G+  +L+G++K+    V Q+      +   R  ++ ++       Q LL       +
Sbjct: 2639 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2696

Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
             L +K      VS    +  + L   Q + +EI   +++++   A  + ++AL   +   
Sbjct: 2697 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2756

Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
             E+   L  + +  ++++   E   Q LQ       + Q+  R+   +  T    Q   H
Sbjct: 2757 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2816

Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
              +   DV E  SL++ H++F + L+      E   A GE L+ ++Q      ++ QL +
Sbjct: 2817 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2874

Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
            I+  W     + ++R  +L  SL+   ++K+ V  L  W+++     + +    +P+   
Sbjct: 2875 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 2934

Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
             +I +     ++ + E+      VE L      LLS     +E +    + L  K + + 
Sbjct: 2935 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2990

Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
             +          MT++  E Q+  ++ +  RQLQ AKEQL+  +     + + + L   Q
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3048

Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
              QK  Q L+ +   ++ LA  +   AS + G   S  +L+ ET  Q+H    + +    
Sbjct: 3049 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3106

Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
            +    +LQ              + +   + +   +P         A++L +K KE    +
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3157

Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
            KA   +++ +++S        + + A+              + + +QC +L       E 
Sbjct: 3158 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3217

Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
              E   + L++  +  +++ + + + E   E + P+    +    +    ++  K +   
Sbjct: 3218 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3277

Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
            LQ ++  + W   + L Q+A   T  +  E      + +  + + L +  A R  +L E 
Sbjct: 3278 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3333

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
             L    F    E L  W+   ++         + P  A     K  K Q Q +   QR+ 
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3385

Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
              R     +++R       +A P     + ++   L + W  L    + R   L      
Sbjct: 3386 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3445

Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
             +   + LE L +     EK       +      LE Q+  H+ LE +++   + L + +
Sbjct: 3446 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3505

Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
             + G+  K+    +   + Q +   +Q W + +Q +   R   L++A   A+ F     +
Sbjct: 3506 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3564

Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
              +W   V   L         + G  K  +  + L+ ++  R++   QA   G + L   
Sbjct: 3565 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624

Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
             G     +Q++L A++ +   + +      + L+   Q    L       C  L+    E
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684

Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
            +L+ +   LK      +    ++L ++ +    +L + ++  +AL E +    R  +   
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744

Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
            +    +R   V +    +   + A++L +  F QAA     WI    ++L   +  GD+R
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3801

Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
               D+    L+ Q  F  E+  H++++  + K G  ++ A S      + ++L  + K++
Sbjct: 3802 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3861

Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
            + + Q  + R  +LE  ++ + +F +  +    W+ E +          +    L Q  E
Sbjct: 3862 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 3921

Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
               QLR  + E + +          I  ++    QL    P E   I ++    +  ++ 
Sbjct: 3922 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3971

Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
               ++ +    L+ A+       + +D + + ++   E L Q      ++E ++  + ++
Sbjct: 3972 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031

Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
            + +  ++  +Q   E+L++    +  RS       +A  ++ +  ++   W  + +  ++
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4091

Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
            R  + LD +  A+K       L+V+ +  +  + D       P   ++  E  +  + E+
Sbjct: 4092 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4151

Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
            D   + + +  + G +L+ A G P    +++ +  L     SL  AW++   +L++A++ 
Sbjct: 4152 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4211

Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             + +   ++ +  W+      LAS   +   L  ++  + + K  + +   Q  ++  L 
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271

Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
              A  L +    E+     +   M L+   ++L  +   R+H+LE  L  L  F     E
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331

Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
            + AWL     +  E+  +  D   +  +L K    Q ++ A     + + + G  L++  
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391

Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
             G  AS  +Q +LE L   W  + + ++++  +L  A  +A      +E+L+ WL   E 
Sbjct: 4392 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
             L A      LP    E L    E+ AA + K    ++L+ + Q  +      A+ ++++
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510

Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
                L ++++S+   L ER+T LE A +L ++F     + + W+ Q +  L  A      
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570

Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
            L  V    ++H+   +E++SH      +  TG  L    +F+  +    ++ L       
Sbjct: 4571 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4627

Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
             EK +  L     R R L    + A+QF     +   WL E    LDSE ++ +  +  +
Sbjct: 4628 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4684

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
              L + +  ++ L A     +   +T   L+ + +   ++ K+   L  +R+    +  +
Sbjct: 4685 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744

Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
            +  R + L+E L       + L  L+D     +   AE Q    D++ V  L +   AF+
Sbjct: 4745 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4804

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
            KE+     + V AL++ A  L  G+      ++ Q   +   WE +     ++   L AA
Sbjct: 4805 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4863

Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
                      VH+  +  AE +  ++    L   ED      ++RTL  QH+   ++LE 
Sbjct: 4864 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 4917

Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
               E+ +  T    +  L    P  +  ++     ++A+ +E   W  Q     A   A 
Sbjct: 4918 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4975

Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
            L   QEL       L WA+        E + +++   + L+ +H+   +E+
Sbjct: 4976 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026



 Score =  209 bits (531), Expect = 5e-53
 Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           ++Q+KTFTKWIN      +    + +LY +L DG +L+ LLE++SG+ LP   +GR+R H
Sbjct: 64  KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 120

Query: 79  FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            L+N   AL +L R +V +  I  ++I DG+  L LGLIW IIL FQIS I +  E    
Sbjct: 121 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 180

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
           SA     KE LL+W Q+ T  Y  +   +F+  W DG  FNA+IH +RPDL+D  ++   
Sbjct: 181 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 235

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
             L NL  AF VAE ++G+ +LLDPEDV  + PDE+S++TYVS  Y    ++ +G     
Sbjct: 236 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 292

Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                 +   + E+   +Y+ +V  L++WI      +  R FP++   ++ L   +  F+
Sbjct: 293 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 346

Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
             E PP+  ++   + L   L+  ++    +     +G    ++ + W  L  A   R +
Sbjct: 347 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 403

Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
           AL+  + +L+ L+ +A R Q  + + E  L  A   L                      L
Sbjct: 404 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 447

Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
           E+G+     +FQ  AEIA  + +       +   RQ  + V  Q L+     Q  Q+  +
Sbjct: 448 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 492

Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
           Q V  L  E+ A  ++   +    R     Q    +  + Q  +   AQ + H +  S L
Sbjct: 493 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 551

Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
            Q  T  L SS  TS                                 VE    +   L 
Sbjct: 552 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 611

Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
           Q+++ L+     + +LL+Q L   E  ++  ++   W+ E   ++     G DL  +   
Sbjct: 612 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 666

Query: 643 LQKHKALEAEVHR 655
           L+ HK     VHR
Sbjct: 667 LENHK----NVHR 675



 Score =  203 bits (516), Expect = 3e-51
 Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)

Query: 872  ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
            + Q WL+ +     +  P   + D LE +   +++F   L     ++ +  +  E L  +
Sbjct: 2800 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2859

Query: 929  YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
              G+    +Q Q   +   W       +E+  +L  S+E     +E   T        Q 
Sbjct: 2860 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2919

Query: 980  QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
             L ++      L P   E++   L+  QK+         +L    + L SV    +E   
Sbjct: 2920 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2976

Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
             E++ L  +V+            L+ + ++ +E  +V++ ++RQ +    Q  + +S   
Sbjct: 2977 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3036

Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
              ++      L++++ S+        L+   DL + +           AQ   + A D  
Sbjct: 3037 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3079

Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
             + +V   +  + Q+   L    +++  +L+  L+ +  F   +    +  A       L
Sbjct: 3080 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3137

Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
            D++    R+A +L +Q       L  L    EAL A  +            +   P    
Sbjct: 3138 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3193

Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
            ++  L+++  Q  +L  R++ R  Q+  +++ L+E+   + E   L+Q  EE     +  
Sbjct: 3194 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3251

Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
            P G         L   K  +  E E L  ++  + +  +G+ L+  + +    + ++  L
Sbjct: 3252 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3309

Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
              + ++W+ LN+K+ +R  +LQ+A           E LL  + D +E +  Q   + +  
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369

Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
                 ++  + LQ+     +S    +  +   +A+ A   A    IL++      R E L
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3428

Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
                  R  QL+     + + H+     N  L+ + + + +  P   T+     + +  +
Sbjct: 3429 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3486

Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
            HK L+ ++  H   + + +S G+SL      + + +V+   +    W  E++    +R++
Sbjct: 3487 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3546

Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
             LQQA+   + F  D  EL  W   V +K   +S +DY  +    + + LR++ +   L+
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3606

Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
            ++       + +E L QT    TG EV    ++   ++ R ++  +   ++A T ++ L+
Sbjct: 3607 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662

Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
               RLH      E+L  WL   +      E+     E A     +  + + + +     +
Sbjct: 3663 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3719

Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
             +   ++ +LLE            MV +  +  +     + +  +    A+  ++   + 
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779

Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
                L  +T+ ++K  SL  ++  +     AQL+  +    E++  +  + +L+++  ++
Sbjct: 3780 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3838

Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
               C   +  +++++   V + +  + +   +R  QLERA+ L+ +F     +   W   
Sbjct: 3839 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3898

Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
             +  + Q+   + E  +   +   H+ LR         ++   K   Q  +L        
Sbjct: 3899 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3958

Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            Q+  +AA T   +++E+++                 D+ DQ+ ++  R  ERL   +Q  
Sbjct: 3959 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4015

Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
                E  ++ E+I   + VS+    L    E ++Q   + E  +      DK  +A   +
Sbjct: 4016 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4072

Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
             K  +   + + +  L++ R    + V ELAE +    H SL++          +D+I  
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4124

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
              + L++P + P  ++ + +     +    E+   +E +  V   G  L+A    P    
Sbjct: 4125 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4179

Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
            V + +  L   W+ L +A   R  +LE+  +  +++   +     W+     K+ ++  +
Sbjct: 4180 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4239

Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
            G DLE   Q    L++F+  +    +    +   ++L L+ K  +  +   +     +L 
Sbjct: 4240 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4298

Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
              W S    ++  Q +LEGA L +      LD +   +   E L+ +    G D ++++ 
Sbjct: 4299 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358

Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
             L KH  L+ +V   Q+ VE++ +    L + S  E A  L+++ + + + W  +  + +
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418

Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
            +R++ LD AL QA+     +++L   L   +  R  + + P    P  A+  L  H E  
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4476

Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
            A  ++  ++       GQQ+L A  P S++  I Q +  L+++  S+E    E + +L++
Sbjct: 4477 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4535

Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
            AL L + F +S++    WL   E +L       P   ++ +L+   +HK+  +  EV + 
Sbjct: 4536 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4591

Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
            +   +E    G H     + Q  +       ++  R E + ++   R   L++ R + + 
Sbjct: 4592 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4651

Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
            F +   ++  WL   EK+L +  E   D   +  QL + + FQ  L A         R G
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711

Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
            + L +    A +   + + L EL   W  +   S ++  KL++A   + +   +++ L +
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4771

Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
            WL  +E +L    P  G  +  V  L+   +  +  + K+    +AL   A+  +     
Sbjct: 4772 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4830

Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
             +  V+ Q + L  R++++      ++T LEA        R A+E  + V   L  LA A
Sbjct: 4831 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 4884

Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
            +              A+R L +QH+    ++    A        G  ++   H       
Sbjct: 4885 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
             H +     + E+ +A  +    R    L      Q+ L  LL    W        D E 
Sbjct: 4945 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5004

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
            +    E  +AL+   +    ++    P ++++ +T
Sbjct: 5005 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5039



 Score =  150 bits (380), Expect = 2e-35
 Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)

Query: 253  QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
            +T+ +++ +   QLQE  L   +++  +  LL W+ + + +L A   P S        A 
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3367

Query: 313  FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
            F + + Q +  +L QR     L  R  T   ++ +  +     E     ++ +  + L+ 
Sbjct: 3368 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3423

Query: 371  AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
               A     + R  QL+ +  +A++F         +L   E+ L          + +E  
Sbjct: 3424 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3483

Query: 431  VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
            + +   LE  I+           I   L+        D+ + + + +  W   +Q     
Sbjct: 3484 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3543

Query: 491  RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
            R ++            +  + L+  +     +L +L     ST    +    + +LQ   
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3603

Query: 542  LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            LL  Q      +V        E L  + G  V ++Q K   +    + +  L       L
Sbjct: 3604 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657

Query: 601  EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
            EQ LQ A  L +  EE   WL +    +         G + SQ   A  + K L+ E   
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3714

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
            ++A+   L      L    P    +  E+  A     ++L+   +  +   +  A+L  Q
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3774

Query: 715  YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
             F  AA+A  SW+ E   +  SL      QDQ +A+          +V + F  E+ R +
Sbjct: 3775 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3825

Query: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
            +             +   L   G  +         +C      + K  L           
Sbjct: 3826 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 3854

Query: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
                  D + ++Y+++  +   R  +LE A +L   F  +  EL  WL E Q+++ Q   
Sbjct: 3855 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3908

Query: 889  P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
            P  + +TL   Q ++      +A  K    +++ +  QL +  PG    IQ +       
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3968

Query: 947  WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
            + Q++   +++AV L  ++ +   F  +       L  ++ +L      S+E      Q+
Sbjct: 3969 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4028

Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
            ++ K + ++  +  LQ +   +++ G               ++ +Q +++ +  + + + 
Sbjct: 4029 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4086

Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
              V +R  +  +  +  + F  +   L++  +  Q  +R  ++  +D +  ++     + 
Sbjct: 4087 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146

Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
            + EEI   QE L   ++  S+ +AA   PD   V  ++  L      L   W+ R   L+
Sbjct: 4147 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4206

Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
            E   +Q   +  DG  A       W+         +  +G D+      +++ ++F    
Sbjct: 4207 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4260

Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
                   E L    E L++  ++    HTV++ L  ++  W  L+ R   R+ +L  A L
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4320

Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
             L +++  + EL+ W+   +GL++  +P G     ++  L +H   ++++LA +  VEA+
Sbjct: 4321 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380

Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
             + G +L+     G+E  ++Q +L+ L  +W+ +  K  +R  +L  A +Q +    +++
Sbjct: 4381 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4439

Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
            D ++ L   E  L +S+    L  + + Q   H ++    E++  T  + M     M   
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4499

Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
               +A   I ++      + E ++  L  R  +L+ ++ L    H S  + ++W+ +   
Sbjct: 4500 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4559

Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
              +  S     L+       +HK    EV +H+ Q+  +  +G  L      Q   +++ 
Sbjct: 4560 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4619

Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
                ++  W ++ +    R + L  A    + F +  S+L  W+EE ++ L S  +   D
Sbjct: 4620 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4679

Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
                   + +H+  Q+ L    S  +  ++T ++L          +    +   LR++  
Sbjct: 4680 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4739

Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
             +   +  R  +LE  L    +F    + L  WL   +      + +  D +  ++L   
Sbjct: 4740 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4799

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
               FQ ++   +  V A +  A  L+E        V+ + Q+L T W  +  L+ ++   
Sbjct: 4800 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4859

Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
               ALR  E    V   LLE L +  E+       +  D   L   +  H+   ++L   
Sbjct: 4860 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4918

Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
              +L +       V  +C       ++      + +     AWA    +  Q+R     A
Sbjct: 4919 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 4974

Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
             L+A+     A+  +  WA     D   E   QE       ++ HQ    E+  ++
Sbjct: 4975 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5030



 Score =  139 bits (349), Expect = 7e-32
 Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)

Query: 824  DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
            D   +   + + Q    +  + +  L      RL      F       EL+ +  KQ  L
Sbjct: 1573 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1632

Query: 884  LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
             + +Q  A  L  +    ENFL     G+ L  E  +  EQ       N  +I+ +Q  L
Sbjct: 1633 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1685

Query: 944  SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
                 + E L +     +    E  + +++   ++ ++ ++L  L  +   S        
Sbjct: 1686 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1740

Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
               + K ++ +   HF +     ++  + E  G      + GQV T Q  L Q  ++V  
Sbjct: 1741 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798

Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
            +     ++ QA    TQ+ Q  L++  Q L   E  + Q   KE+ V   +A   L E +
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 1855

Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
              ++  H  QE L++ DA           D  E  + L+   Q  QEL+ L         
Sbjct: 1856 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 1901

Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
            L   L+ QK       F+    +H+  L ++   G  V EA     + R+ G+ + T   
Sbjct: 1902 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 1953

Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
              E  R   H     +S +   + +   L+ +  ++   +  S      LLA LQ  E  
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2007

Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
               A   + + E     A +P    +N+ + L+  +A + ++ + +  VE L++    LL
Sbjct: 2008 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2057

Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
              R      + DIQ  L  +  ++E L++ + ER ++LQ       L R L  QD  +++
Sbjct: 2058 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2112

Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
                G ++SS  E GQ   +S  LQ    ++  LE +     + + A+            
Sbjct: 2113 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2172

Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
             S A  + A     S    E + KH   L  ++       L    S +L  F       L
Sbjct: 2173 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2232

Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
            + V   +P    T  ++ +  + S   +HK+           ++ + S  + +++ G P 
Sbjct: 2233 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2280

Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
             + +V E+   L   + E+E       EA   C +Q   FQ   + V  L+ W++E    
Sbjct: 2281 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2337

Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
                +P   + D G+    T +L  K      E+    +S   L      +T P      
Sbjct: 2338 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2397

Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
                                        + +    +     +    L++  A  + +L  
Sbjct: 2398 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2456

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
              +L +   E+  +  WL    + A   +      D E       +   F+ +++    +
Sbjct: 2457 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2514

Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
            V   +     LLE        P  +Q   ++ + W EL +LT  R   L ++   L   +
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574

Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
             +   L Q    +E   S+   ++ D   L  Q +  Q L +E   T +   E L  AG+
Sbjct: 2575 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2633

Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
                 PG        V+++  AVTQ W  L  ++  R   +++A + + ++++ +R  + 
Sbjct: 2634 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2693

Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
              + +   L    + S  P +   +L   Q ++ E++  +K  + A  L +   AL+   
Sbjct: 2694 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2753

Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
                E+  +L  +      V Q      + LQ+        ++  R  +  +   +E   
Sbjct: 2754 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2813

Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
            K+  + + ++ +E LI+ H+ F K LTAQ    E  + E    L + +  ++  + LQ  
Sbjct: 2814 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2873

Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
                       +VKE       +L  +L    + +       WI      L+E     D 
Sbjct: 2874 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 2930

Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
             +    + K ++ + E+  H  ++  +     +LL+        V+   + L +  + + 
Sbjct: 2931 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2990

Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
            + +  +   LE+  + F EF +    ++  +Q  + ++++ D LG               
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050

Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
                Q L+H + L +RL +     A D+ G       SD+ LQ        V+ I Q  S
Sbjct: 3051 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3096

Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
             L+             QQ  E    +    + + +    I  +E   Q  +   +L+S+ 
Sbjct: 3097 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3141

Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
             + R  E L+++   I+A ++ LE          + C       + SP+   G++   + 
Sbjct: 3142 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3200

Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
            +++   +L  RAQ R E ++  + + ++  + L+E  +  Q+     ++        E  
Sbjct: 3201 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3260

Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
                 M +  Q  K E++            GQ L+ +    +S       GLE +L  + 
Sbjct: 3261 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3313

Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
              W+       +   QLQ+A L    F  ++E +  W+   E+ +A++    P A  + +
Sbjct: 3314 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3371

Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
               + + K+L+  L+ +   +  ++     +     P +    L +   +  R EAL  +
Sbjct: 3372 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3431

Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
            A TR  +LE +  + Q F +  + +  WL   EK LV  E      + L  Q+ + +  +
Sbjct: 3432 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3491

Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
             + ++ + H  Q +       +       + +Q +L+     + E+Q+ S  +   LQ+A
Sbjct: 3492 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3551

Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
             C A        EL NWL  +  +L   +V   +  G+ +     R L+  +  + +  +
Sbjct: 3552 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3611

Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
                  QA +     L Q   ++              +Q++  A++AR      ++D   
Sbjct: 3612 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3646

Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
                   KL    A+   Q+L   R L   H+ L       E E+ S+E  T+V+ G   
Sbjct: 3647 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3695

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
                       E A++ Q   K    L+ EA   + LL    E    L EL+    W A 
Sbjct: 3696 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3738

Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
             G   + +ED       +  + +++E    +++A   R ++  Q A              
Sbjct: 3739 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3781

Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
             A+L  + E   +L+   + R    Q   QL   +  T+ +             +D   D
Sbjct: 3782 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3830

Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
            L  VK   +   A  +E +   + K+  + K   T+ +    RY  ++  +S +   WE 
Sbjct: 3831 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3888

Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
             ++     TE           Q   ++L     E               ++R  Q++HR+
Sbjct: 3889 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 3925

Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
            L   +   +  + ++     +L +L P     + +   A  TL ++ +E          +
Sbjct: 3926 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3985

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             ++Q+ Q H  + +  E L    ER  L     ++ +V   ++ + +++ +  ++ + + 
Sbjct: 3986 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4043

Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
              + L+Q G++++  S     +++   + ++ +L ++   W
Sbjct: 4044 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4082



 Score =  136 bits (342), Expect = 4e-31
 Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)

Query: 469  VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
            VA RQ+E   + Q +   L Q + + +   +A +     VE   +Q   EELQ+  + +A
Sbjct: 1581 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1640

Query: 526  CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
              Q LAEVV           E L + D       L EA++     ++    Q   ELD  
Sbjct: 1641 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1697

Query: 568  LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
            + T+++    K   + QL++S   +                     + ++EQ     Q  
Sbjct: 1698 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1757

Query: 608  EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
            +      EE+       +   +  +G     +    QK KA  E  + +HQAV +     
Sbjct: 1758 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1817

Query: 667  GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
               L  +     P+  E+ +      ++     +    +       LQ     + AD  E
Sbjct: 1818 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 1877

Query: 722  AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
               WL++    LE    G D      T L+R       + +   +LR +   G      A
Sbjct: 1878 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 1937

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                                     SC    G         + D       + +  DH +
Sbjct: 1938 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 1965

Query: 841  QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
              + SL +   +    L++ +  +     +SCG                          L
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2025

Query: 874  QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
            Q  LE+   L  ++  Q   +E ++   E  L A         ++  + + +  RY   S
Sbjct: 2026 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2085

Query: 934  TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
              +  + E+L               + L  S+ V   L E       +   L +   +  
Sbjct: 2086 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131

Query: 994  GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
             S+     ALQ    K ++LE+ +   QS +  + E      +        +LQ  +K +
Sbjct: 2132 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2186

Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
              + ++ + +  ET A+   L+   +L    +E +Q  L +K     EV V       L 
Sbjct: 2187 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2246

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
            +  Q+   E    ++ L+ L +  + ++      S  +P+   ++ ++   L   +++ +
Sbjct: 2247 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2300

Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
              ++E  E +     ++D F     + ++W+                ++LG+ + +   L
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2360

Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
                      +Q+    G     L+S +   A+A+ A   G  ++  +  A +T      
Sbjct: 2361 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2420

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
            + L SI+   T +    E     L   +A L     +LQ+ +++ + +MQW+++    A 
Sbjct: 2421 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2480

Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
                 P+      ++T ++++++ E+EL      V+ L+    ELL   P   E  + + 
Sbjct: 2481 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2540

Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
             L  + SKW+ LN+   +R  +L+++      L Q Q  + QL+Q  +E  L  S  G  
Sbjct: 2541 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2597

Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
                  L  + QQ++    E  T   +   L +   G+ + P         + E+     
Sbjct: 2598 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2657

Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
            ++ + L G L+ R   + QA V+  Q+  L        S+++    +       P +  +
Sbjct: 2658 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2717

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
             L  AQ + ++ ++ + ++K  Q   + +  L     L A    Q + I++      Q+ 
Sbjct: 2718 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2777

Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
            E H   L+ AC +  Q  Q +  FQ + LD  + E      +  K  ++ S     +D+ 
Sbjct: 2778 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2836

Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
            +   A   +  K  A  E L +     E+     Q  T          +V E++  ++E 
Sbjct: 2837 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2896

Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
            L + L+                  L+E+    D  E E ++ +L    +E +   G +  
Sbjct: 2897 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2956

Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
                A    S+ E D E                    H+   C      KF +FQ +V  
Sbjct: 2957 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3015

Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
             S+R   C   A+  L+   S G          M++ +Q+ LQ            A   +
Sbjct: 3016 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3072

Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
             E + ++G    L   ET  + H  L +   QV EK + L           N  R++   
Sbjct: 3073 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3129

Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
                + +L S   + R+    ++Q          L+ L+ +     K C          P
Sbjct: 3130 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3189

Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
                +++  +A+++    L  R + R  Q+E   + L  F + +++++     + Q  + 
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3245

Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
             E SQ P     +    Q      + + E+E  +   Q    LGQ  + +A   T     
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3300

Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
              + L+   D V   W    +++ Q   Q Q  L  CGR ++ L +        +E+   
Sbjct: 3301 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360

Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
                 +  + V+  I++ ++  ++L  +      ++   E++ T   P    ++  +L +
Sbjct: 3361 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3420

Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
            L  R   +   AE+R   L   S++   F +      +W+    ++L    P G    KL
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3480

Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
             + + +H+A E ++  H + +      G++L   S     ++ Q      + W       
Sbjct: 3481 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3540

Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
                 E L+QA+       ED    + +L  V        +K  K++V D   +     Q
Sbjct: 3541 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3593

Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
               R+ +         V  A +  +      LK    +EV II  +   +  R+      
Sbjct: 3594 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3649

Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
                 + LE AL+    +H    EL     ++ E E L       K  E+ Q  +R  +E
Sbjct: 3650 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3707

Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
            L++E    +A ++SL      L +  P  A  GL     E  E +  +     ++ E +D
Sbjct: 3708 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767

Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
            A  L   Q  QA   EL    +  +  M          +    L+  +    E+    D 
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827

Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
            I     +G +++TA        +++ L  + +   ++     E  LQL++A  L   F  
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887

Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
            + E++  WL   +  ++   L  P    E L     +H+ L   +      I  +  T  
Sbjct: 3888 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3945

Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
             L +    E  S   +  A       +      R   L+E          ++   L+  +
Sbjct: 3946 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4005

Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
             +   LR+   ++ E        +  Q+ + +N   +++      + L++ G+ ++   G
Sbjct: 4006 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4060

Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
            G     +++A+Q++L+++  +W  +    +++ AKL           C+ + L  ++++ 
Sbjct: 4061 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4120

Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
            ++++  +E     P+V +      E +     G Q EL+  ++    +  A  G+    +
Sbjct: 4121 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4179

Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
                     V++    L   + SL +  ++R   L EA    +++         WV    
Sbjct: 4180 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4230

Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
              LA+    G  L  V+   E+          Q +E E  +H+A  L + V     K   
Sbjct: 4231 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4287

Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
                  H V   + +L+     L      R+  L+ A  A  QF   L E  +WL    G
Sbjct: 4288 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4341

Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
             + + + +G   +A +  L +    + D+ A    +E + +    L+ES    E+  +  
Sbjct: 4342 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4401

Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
            +L+ + +    +L + E R              HG  E LQ    + E  LL +      
Sbjct: 4402 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4461

Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
                 +     +E     E K + ++  +Q  GQ  +    K A T          +I  
Sbjct: 4462 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4510

Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
              + ++  WE ++  +  R     E L  A E H+  Q    +    Q +  L       
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4568

Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
              L +V     +H+    E+ +  +++  L      L          L K     VQ  W
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628

Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
              +  +  ERG+ L  A  +   F     +L+ W +E ++   SE E+A D    +  L 
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688

Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
            QH+E  + +           + G+ L + +      +     +L+  L EL + W
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4738



 Score =  132 bits (331), Expect = 8e-30
 Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)

Query: 306  MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
            + Q L  F +F+ +E  P   ++     L   L  +         L H+   L +++  W
Sbjct: 3260 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3316

Query: 366  AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
              L    A R+  LQ+ LL          RFQ       S++ D E+++   + P A   
Sbjct: 3317 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369

Query: 426  TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
             V+A +Q   +L+           ++ +EG +    AE AD ++         + ++   
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3420

Query: 476  VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
            +  RW+ LL   + + +Q+  +  V     E +E  +  L  +++  R   C   G Q +
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3478

Query: 532  EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
            ++ E + +H  LE  +  H  H+            S+G S++VL +   K    ++L  S
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3530

Query: 589  LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
             V  +       +R  LL+Q L  A+     E E   WL E   ++   ++    ++   
Sbjct: 3531 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3590

Query: 642  ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
              Q   + L+ ++   +      +  G +L       +   G+    +Q   + ++    
Sbjct: 3591 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3640

Query: 701  GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
               AR +    +    A   E A  L  R  S     C         LL    ++ +   
Sbjct: 3641 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3697

Query: 761  AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
            A  A++R  E +  A + +A L ++N   S   E +                  W+    
Sbjct: 3698 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3740

Query: 821  AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
             E     D        D ++Q  E + A A LR  + ++A        +  EL  W+   
Sbjct: 3741 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3790

Query: 878  EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
            EK+ + L  ++ + D         + F   +   K +  ++  S  ++         Q +
Sbjct: 3791 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3850

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
            +++ +++ + +  +  +  E+ +QL  +  + +      +E  P   + + ++ QL A  
Sbjct: 3851 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 3908

Query: 993  PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
            P    +T    Q    Q + L+ E + H   +     ++ E    E   +Q +      L
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3968

Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
              Q++E V +RA    E  ++ + F  +  Q+L   E +  +LR    +S +V   +  +
Sbjct: 3969 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4028

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
             E++++  ++   Q   + L  + + M A      +++  + + +  +  ++  +WE   
Sbjct: 4029 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4086

Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
                +R+  L + +EL +KF  +      T  + Q ++  L++ G             E 
Sbjct: 4087 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146

Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
            +RE +  LQ+  +   ++  LG  +E + A GE       P    V++ +  + + W  L
Sbjct: 4147 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4194

Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
                + R  +L  ++Q     QD +  +  W++   G +A+  P G     + Q ++  +
Sbjct: 4195 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4254

Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
              +SE    +  +E L     ELL ++   + D   +Q  L  L+  W++L  ++  R  
Sbjct: 4255 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4313

Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
            +L+ A    GQ +  L +L      L   EG L   +  G D ++ +    +H  L+++ 
Sbjct: 4314 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370

Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
                + + A+    + +  S A  EE      +LE+L             R  QL  ++ 
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429

Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
              +  H    +L  W+ +   H        G P +  E LN        H E+    +A 
Sbjct: 4430 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4482

Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
            +   + ++  G+ + A     A+  ++Q    L+  W  +E     R   L++A+     
Sbjct: 4483 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542

Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
            F + + +   W+ +      V+SR     +    + I++H+    E+  +   + ELD+T
Sbjct: 4543 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4601

Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
               L      ++Q VV         Q R  + ++ L E   + D   +   + HE   + 
Sbjct: 4602 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4658

Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
              L  WL   +++      +  DP+       +  +FQ  +               SL E
Sbjct: 4659 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4716

Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
            +   A   ++      +L+  W  +   +  R + L +         D L+ L       
Sbjct: 4717 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4776

Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
            E   +    V  D+  +   + +H+  ++EL      +Q L  +A   ++L  G +  + 
Sbjct: 4777 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4833

Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
             V+ + Q ++  W  +      ++ +LE A R    F + V     W A   Q L+    
Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4893

Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
              +       L   H+    +LE +     +AT +G   L      +    +    +   
Sbjct: 4894 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
            R +    WA++ ++  A     L  ++   LE +LA  + +  T        +   +EEV
Sbjct: 4954 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5012

Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
            + LI +H+ F++ +T   +K+  + +  KT +R R  D  P  LQ  + V +   +    
Sbjct: 5013 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5066

Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
              AS L  S +Q   + ++         W Q W   L+      D  D+L+ L +   F+
Sbjct: 5067 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5126

Query: 2161 AEV 2163
             ++
Sbjct: 5127 FDI 5129



 Score =  110 bits (275), Expect = 3e-23
 Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)

Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
            ++  L Q +T ++  +  V +L  WV+E +  +   ++G D  +    +  H+ +   + 
Sbjct: 619  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 678

Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
             + SS++E   +   +T P ++   +++   RL  Q   L   +  ++R L+    LH F
Sbjct: 679  EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 733

Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
            +  A +   WL ++K+  +      E   +        A+   +++   + + + + +AE
Sbjct: 734  VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 792

Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
             LL   H A   +   +  +QT WS + +L Q     +++         D  E    ++ 
Sbjct: 793  QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 852

Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
               ++    +   C   + +   + L +E   +  + +ELL+    +  L          
Sbjct: 853  LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 896

Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
                 + +A  ++Q +       L+ +  +     A+ DY           Q+E +  + 
Sbjct: 897  -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 937

Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
                L  ++H   RA+       W+  +  G +A++         P KE  +    ++ Q
Sbjct: 938  DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 987

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
               V   W      +++       + E   ++ I A+   S+KT   G   + +  L  +
Sbjct: 988  YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1044

Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
             E FL     +D +E+ +       +  +  +      Q  ++  E  E        +L 
Sbjct: 1045 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1097

Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
            ++       + E+      +Q++ P+   DL + +  + + +  + E++  ++ + ++  
Sbjct: 1098 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1157

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            K E   +Q+   +   + R + L    +++ Q  ++    ++  +     L+    AEA 
Sbjct: 1158 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1216

Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
            ++  E K+           N+ +L   L+   Q R  + E R   ++  D +  A  ++I
Sbjct: 1217 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1271

Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
            SD   +       +     ++  QL  RW + H        Q++  L             
Sbjct: 1272 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1311

Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
                            +DLE + + L+ + +     HP+   ++ +E    ++ +  PE 
Sbjct: 1312 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1352

Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
            +  L  +  QQ++  S  +++       QK  E   A  +  +LQ M    +V +Q+   
Sbjct: 1353 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1409

Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
                    +SPV+ RRM         E +D  T   +L     Q +  AG          
Sbjct: 1410 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1453

Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
            L  LE+E  SLE   +EH   +++A ELQ ++S++ K              ++ + S+E 
Sbjct: 1454 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1510

Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
            S   E L + L  ++  L KH  KM + +      ++  L+ +   L      + Q +  
Sbjct: 1511 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1570

Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
                 +  K    RQ    +   E+L+ +   L  +        E  L+  +E  +    
Sbjct: 1571 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1618

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
            T  L     KQ+  Q ++  S     E+ +  +  L + G   S+     I+++L E   
Sbjct: 1619 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1678

Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
               +L    + S+K++ K+         +K     +L  S  ++EN   WL  ++ +  R
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1738

Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
            A T                     +G+     G LL          TQ  L     K   
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798

Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
            Q E ++ Q QA +           ++G  L+ + +E+ ++ ++  K     +L E  ++ 
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858

Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
            +     +  L KF  D  E   W+Q+ +  L   +     ++ +    ++ ++   ++ S
Sbjct: 1859 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1918

Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
            H+   R +  +G ++++A    +     +V          ++L+ A    R+  ++  +L
Sbjct: 1919 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1978

Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
                ++         +A   L       ++    H +E      + L R+LE TK     
Sbjct: 1979 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2038

Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
            + +    +E+L++TA  LL++R +  P    +   L  +   + +L +    R   LQ  
Sbjct: 2039 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2098

Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
            L      ++ L  +LD W+    ++ + Q          QD+    ++ E+  A R    
Sbjct: 2099 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2153

Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
               Q+ + A+  K+   +E   P     +QA+   + A   R  +A     E LA   E 
Sbjct: 2154 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2207

Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
               V  F+  + +LQ  ++ KT AL + +  G  ++ +    Q       +H++    L 
Sbjct: 2208 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2267

Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
            ++ KE++                P   A V E    L  K +E    + +  +       
Sbjct: 2268 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2315

Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
               AF    + L +W    +E      + +   GAE L    E+  +   +  L+  +++
Sbjct: 2316 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2372

Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
            +     +   + +SA  T             +   EG     EE WA +        GL 
Sbjct: 2373 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2424

Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
             +++ +                 D  H   D+ LLL       +  L KL  AQEE  A 
Sbjct: 2425 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468

Query: 3444 MQ 3445
            MQ
Sbjct: 2469 MQ 2470



 Score =  108 bits (270), Expect = 1e-22
 Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)

Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
            +VAS + +L  EHQ +L  +   Q R +     SQ        D  ++   + V  Q  Q
Sbjct: 1022 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1078

Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
            EL    E+ +Q   E      +  EV        N +          L  D+L E V   
Sbjct: 1079 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1135

Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
                +  +E  RL   LG           +   S   +  T+R +L  +     ++   S
Sbjct: 1136 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1193

Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
                 +L  ++ L       AE +  + E  L         + NI   +   +   SE+ 
Sbjct: 1194 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1252

Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
              R+   AL+    EL   +    E  +T             +   L  +W+ ++ ++  
Sbjct: 1253 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1309

Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
            R  +L+  G+  +  R     L D  +Q+E  +  +Q ++       + +L ++ + L S
Sbjct: 1310 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1368

Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
            E     +KM      A   +A+    E      R +   Q    ++  ++Q+S +L   +
Sbjct: 1369 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1428

Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
            F  L     + V         T Y +    + + L  + K L+ E K H       Q  V
Sbjct: 1429 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1482

Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
              +  + +    +G P         +E+     +L  A +          T Q +     
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1527

Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
                       L    D   DE     L  + + LQE   + +S  E L Q  ++ T  +
Sbjct: 1528 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1573

Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
            V  ++++V ER +E    LQ     L  T +R +         +GT+ L ++  + E+LQ
Sbjct: 1574 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633

Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
              +    QA             + GE L ++ +  +      AK + +            
Sbjct: 1634 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1693

Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
                    ++  +++VAA + L ES  +  +     +    +D + A ++  ++ +  G 
Sbjct: 1694 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1752

Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
              ++ +          V+ +LLE  T V  +  +   N+ +    ++AQ        + +
Sbjct: 1753 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1810

Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            +   +  Q LLE  G  Q L P  +    +  ++        L    ++ +        L
Sbjct: 1811 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1868

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
             +F     ++  W  +  Q+L+  E+  +  +G + KL   +    ++ + +   +  T 
Sbjct: 1869 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1928

Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
             G + L AA + +K             EVQ +L    D+   +Y         L+   ++
Sbjct: 1929 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1988

Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
             +      CG L  + A +  + K  +   +V+  + L R+ E   K L  Q   +    
Sbjct: 1989 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2046

Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
            E+LK      +  R  +L     +Q+ +     R ++L++S   R   L  +L  + S  
Sbjct: 2047 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2106

Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
                +  DW+      LKE    P+    L+D +    K+   E ++   +  + ++ +K
Sbjct: 2107 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2163

Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
             +  +  + P  A  +  +++ L   + +          ++E+ +  +E  + + +  + 
Sbjct: 2164 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2223

Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            +++ K   +   D+ G+D+    Q ++    EF  +     V  + ++ IS   L     
Sbjct: 2224 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2278

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
             P +  ++ ++ + L+ ++      +   ++ +    E      VL + L +  K   +K
Sbjct: 2279 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2337

Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
              ++Q    A D GK LE  ++L  K      E+  +     SL   +  +   +   A 
Sbjct: 2338 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2397

Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
                G     +  A   E +W                         L+ +  +    L  
Sbjct: 2398 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2457

Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
            L +AQ+  + + + L    +   +   +PAP      +  +E+++  +AEL    + +  
Sbjct: 2458 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2517

Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
             +    +LL          R      +Q L+ ++  WQE +QL +  QQ LE     L  
Sbjct: 2518 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2572

Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
            F +   ++++WL  KE  ++  G   PL+    +L     + ++L  +   +  +   L 
Sbjct: 2573 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2629

Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
            A  +G+    G  P  +  +    A + +K ++L  Q   R   +++      Q Q+ L+
Sbjct: 2630 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2689

Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
               +  + L  K   +L       AM   QL+  Q  + E+     Q    Q L  +   
Sbjct: 2690 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2748

Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
            L++  +  +E +  +LE +   + +++  ++  V  LQ AC  + + ++   + + WL+ 
Sbjct: 2749 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2807

Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
              E + ++  +   L  +  L+   ++    +  ++   E  + + +   ++        
Sbjct: 2808 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2867

Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
            ++ Q   +   + +  + ++ER   L E+    LK+    +    W+   Q  L  +   
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927

Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
             D  +  +++  L    ++L+ EM  H  +  ++  T   L+         V    + L 
Sbjct: 2928 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 2983

Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
            + +  +  +   ++  L+   Q+ ++F     E+   L      LD  D   S   +   
Sbjct: 2984 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3043

Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            L  L+  ++ L+A   +++  ++ A   ++E+  +  +  VL Q++ + + H+ L ++ +
Sbjct: 3044 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3103

Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
             +   L+ +LQ        + ++  +    D  L + A        G+D E ++  +E  
Sbjct: 3104 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3157

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
             AF K++++L  +   A +     L        P +   +  +EA  +   Q  K     
Sbjct: 3158 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3212

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
             A   +V    +   E   +++E + L+ K E+   S   V     T+ QQ        +
Sbjct: 3213 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3272

Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
             E+E ++ +    Q +   LGQ  +  AA           L  V   W TL  K  +R  
Sbjct: 3273 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3328

Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
             L +A      F    + LL+W  + +EL ++++         +   Q ++L Q + + R
Sbjct: 3329 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3388

Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
                + +++EG+++   +      ++ + L  L+ R +  L +A     Q    S   Q+
Sbjct: 3389 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3448

Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
              + LE    WL   E  L+  +  G   S +E  + +H+ LE                 
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3508

Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
               K+L+++E+K     K +  Q   ++ QE    R+
Sbjct: 3509 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)

Query: 246  CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
            CS   + Q+++++L K+L              LQL+  + L  Q+ +   +L  W+ E Q
Sbjct: 3842 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3900

Query: 292  MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
              +        LPA    L   T+ + QE+  +L++      L+   +  +   N+    
Sbjct: 3901 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 3946

Query: 349  --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
                 P EG  + E    +   +   +   + +++R + L    + + +F  K    +  
Sbjct: 3947 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4000

Query: 407  LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
            L+  E+++++ R PP+  A VE   +++   +   +  E + Q L E      +E     
Sbjct: 4001 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4059

Query: 465  -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
                   S   V  + +++   W+ +   ++ +  ++ D+  +        +SL+  ++ 
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4119

Query: 510  ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
                + +L++P    +  +Q  E  E ++   D L+ ++       S L     E D   
Sbjct: 4120 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4178

Query: 569  GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
                 +++     L     SL    + R   LE+ +Q A ++    +    W+   G ++
Sbjct: 4179 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4233

Query: 628  GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
             + + +G DL  +   +++ K  ++E ++ Q + ++ +    +L  ++   + D     +
Sbjct: 4234 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4292

Query: 687  AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
             +      W  L+ R++ R  +L+ ALL L  F  A  E  +WL      L E+   G D
Sbjct: 4293 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4352

Query: 742  QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
              A E  L +H  L+  + A  + +                     A++  G  L     
Sbjct: 4353 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4392

Query: 802  WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
              EAS                         +    + L+Q ++++    + R+ +L+ A+
Sbjct: 4393 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428

Query: 862  -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
                GF     +LQ WL   E+  +  + +    +T +     +     A    +  +  
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4488

Query: 918  VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
            +    +Q+  R P ++ T I +    L ++W  +E    E+  +L    E  +   E   
Sbjct: 4489 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4545

Query: 977  TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
            +     + L Q E     A +P    DT    Q+ + K    E   H  +  ++++++ G
Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4602

Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
                 +++ Q    ++  + ++Q   ++V +++ +R R   + + R + F +   +L+ W
Sbjct: 4603 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4662

Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
             E  +  L S+ E++ D    +  L +H++  + +   H   +   +     +   +L  
Sbjct: 4663 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4721

Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
             D+ ++ + L  L  +   +     +RQ  L+E L     G+  D   A       WL+ 
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4775

Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
                L E      D+   ++L+  H+ F + L       +AL+    +L++     +  V
Sbjct: 4776 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4835

Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
            + Q+Q +  +W  +   S  ++ +L A+L Q +E+   V  L++W+ E +  +  H    
Sbjct: 4836 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4895

Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
               + L+TL  +H+    +L   R  +     +G  +L+   C  + I T        W 
Sbjct: 4896 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 4948

Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
             + R   E  + L  A Q +Q L      L   +E LE L   LQ +ET    +  + + 
Sbjct: 4949 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5006

Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
               Q++E     +A     +  M       P + + T+ + RR      LQ H+ +
Sbjct: 5007 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5056



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)

Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
            Q   ++E  ++ +QD    +++++  L  +E G DL S +   + H+ +     E ES  
Sbjct: 625  QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 684

Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
              AK++ +   A      P  L   +K L RLE     L       +  ++ LH F   +
Sbjct: 685  KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 737

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
              EL W+ E         ++E           H EL  E+   +  ++ V      L   
Sbjct: 738  TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 797

Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
             HP    I      ++  W+ + + C+   Q +++   + ++F D  E   ++   +  +
Sbjct: 798  NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 857

Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
              R Y  D ++++     L+ +    +EEL  Y S++  L   A+T+
Sbjct: 858  -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 903



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)

Query: 209  VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
            V E +  + +LL+        P  + ++T +   +   ++L    T+ R+      +L+E
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2565

Query: 269  TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
            +    TQ++ + A L +W+ EK++ +         P+ L   RQ +          KP  
Sbjct: 2566 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2625

Query: 325  LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
             Q   A + +L R     +  + R  +  +   LA ++Q W  L    + R   + Q ++
Sbjct: 2626 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2679

Query: 385  QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
            +  + ++L R    K +  ++ L  +  V     A    L T +   Q +   +  I   
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739

Query: 445  EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
                QAL E    L +E+Y   A+++R+ E +   ++ + Q  +            +  L
Sbjct: 2740 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2784

Query: 505  QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
            Q   A+SHQ +++            +E  +S     +L  +  L++ H      ++A   
Sbjct: 2785 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2842

Query: 553  HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
              SH+ ++T     +L     G+    LQ +  T+     +    V+ R   L+++L++A
Sbjct: 2843 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2900

Query: 608  -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
             ++    E    W+ +C   +       D ++   ++ K K+L+ E+ +H
Sbjct: 2901 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 2950



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)

Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
            +L   + E    +   + G  L SV +  + H+ + R +E  E  +     +  ++ ++ 
Sbjct: 639  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 693

Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
              AP  L       +++  +A L   ++ + + L      H F+ R    L W  E++E 
Sbjct: 694  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 750

Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
              + + +E      +    H EL +E+ +     + +++  +QL+  +H   A +T    
Sbjct: 751  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 804

Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
             +E     ++  W+   Q C      Q + Q +++  A+   +       DY  ++ D  
Sbjct: 805  -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 856

Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
              + R    ++  ++   K   + +  ME+ E LLQ +       G + T  Q +P
Sbjct: 857  --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 908



 Score = 40.0 bits (92), Expect = 0.042
 Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)

Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
            Q LL W + +Q QL   E   D+ S +  L  H+++   I  ++  L++       M A 
Sbjct: 638  QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 696

Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
              P        L  L  + Q  K+L   R Q        ++    +  F +   N   WL
Sbjct: 697  --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 744

Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
            +    + +  D  E  + + +    H E  R L       ++++   E+L+   HPA  T
Sbjct: 745  NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 804

Query: 1250 VREQLQSIQAQWT 1262
            +     ++Q QW+
Sbjct: 805  IEAYRAAMQTQWS 817


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  222 bits (566), Expect = 5e-57
 Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)

Query: 408  KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
            K+ ++ L++ +A    +++ + AV++L      +L+A   +LP +   Q   +  DI+ +
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2091

Query: 461  EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
             +  S   V  R E++ +   R L    G  + +  M  V S L+E         + Q P
Sbjct: 2092 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2141

Query: 521  ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
              STA       + +++ ++ +LE  ++   + ++ + ++  + ++++  ++   LQAK 
Sbjct: 2142 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2194

Query: 580  RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
            + L+          +   A +E+   + E   N  E+ + +L+   Q +    + G+D++
Sbjct: 2195 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2254

Query: 638  QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
            +++  +Q+  +   E  +H  V   L++   ++S+   P+      E+   +   ++ ++
Sbjct: 2255 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2311

Query: 697  TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
              +  +   + +    L  F    ++  SW++E   + ++    Q    AE L   L   
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2368

Query: 753  VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
             +L+        E++++   G       SL  + SA++ P +++      S  +   G G
Sbjct: 2369 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2420

Query: 813  DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
             A           +F  N    +I +    +S  YE L  L + + A L   ++ L    
Sbjct: 2421 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2473

Query: 868  SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
                 +  WL+K      + Q  P     E ++ + E   +F   L        E+    
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2533

Query: 923  EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
             +L +  P      + +Q   E+  +W +L  L  ++  +L  S    + L +    + Q
Sbjct: 2534 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2590

Query: 981  LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
            L+  L++ E     L P S +      Q  Q + L+ E      Q   +     G   S+
Sbjct: 2591 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2649

Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
            P  G+  +L+G++K+    V Q+      +   R  ++ ++       Q LL       +
Sbjct: 2650 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2707

Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
             L +K      VS    +  + L   Q + +EI   +++++   A  + ++AL   +   
Sbjct: 2708 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2767

Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
             E+   L  + +  ++++   E   Q LQ       + Q+  R+   +  T    Q   H
Sbjct: 2768 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827

Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
              +   DV E  SL++ H++F + L+      E   A GE L+ ++Q      ++ QL +
Sbjct: 2828 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2885

Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
            I+  W     + ++R  +L  SL+   ++K+ V  L  W+++     + +    +P+   
Sbjct: 2886 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 2945

Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
             +I +     ++ + E+      VE L      LLS     +E +    + L  K + + 
Sbjct: 2946 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001

Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
             +          MT++  E Q+  ++ +  RQLQ AKEQL+  +     + + + L   Q
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3059

Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
              QK  Q L+ +   ++ LA  +   AS + G   S  +L+ ET  Q+H    + +    
Sbjct: 3060 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3117

Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
            +    +LQ              + +   + +   +P         A++L +K KE    +
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3168

Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
            KA   +++ +++S        + + A+              + + +QC +L       E 
Sbjct: 3169 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228

Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
              E   + L++  +  +++ + + + E   E + P+    +    +    ++  K +   
Sbjct: 3229 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3288

Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
            LQ ++  + W   + L Q+A   T  +  E      + +  + + L +  A R  +L E 
Sbjct: 3289 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3344

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
             L    F    E L  W+   ++         + P  A     K  K Q Q +   QR+ 
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3396

Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
              R     +++R       +A P     + ++   L + W  L    + R   L      
Sbjct: 3397 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456

Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
             +   + LE L +     EK       +      LE Q+  H+ LE +++   + L + +
Sbjct: 3457 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3516

Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
             + G+  K+    +   + Q +   +Q W + +Q +   R   L++A   A+ F     +
Sbjct: 3517 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3575

Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
              +W   V   L         + G  K  +  + L+ ++  R++   QA   G + L   
Sbjct: 3576 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635

Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
             G     +Q++L A++ +   + +      + L+   Q    L       C  L+    E
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695

Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
            +L+ +   LK      +    ++L ++ +    +L + ++  +AL E +    R  +   
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755

Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
            +    +R   V +    +   + A++L +  F QAA     WI    ++L   +  GD+R
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3812

Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
               D+    L+ Q  F  E+  H++++  + K G  ++ A S      + ++L  + K++
Sbjct: 3813 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3872

Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
            + + Q  + R  +LE  ++ + +F +  +    W+ E +          +    L Q  E
Sbjct: 3873 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 3932

Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
               QLR  + E + +          I  ++    QL    P E   I ++    +  ++ 
Sbjct: 3933 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3982

Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
               ++ +    L+ A+       + +D + + ++   E L Q      ++E ++  + ++
Sbjct: 3983 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042

Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
            + +  ++  +Q   E+L++    +  RS       +A  ++ +  ++   W  + +  ++
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102

Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
            R  + LD +  A+K       L+V+ +  +  + D       P   ++  E  +  + E+
Sbjct: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162

Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
            D   + + +  + G +L+ A G P    +++ +  L     SL  AW++   +L++A++ 
Sbjct: 4163 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222

Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             + +   ++ +  W+      LAS   +   L  ++  + + K  + +   Q  ++  L 
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282

Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
              A  L +    E+     +   M L+   ++L  +   R+H+LE  L  L  F     E
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342

Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
            + AWL     +  E+  +  D   +  +L K    Q ++ A     + + + G  L++  
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402

Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
             G  AS  +Q +LE L   W  + + ++++  +L  A  +A      +E+L+ WL   E 
Sbjct: 4403 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
             L A      LP    E L    E+ AA + K    ++L+ + Q  +      A+ ++++
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521

Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
                L ++++S+   L ER+T LE A +L ++F     + + W+ Q +  L  A      
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581

Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
            L  V    ++H+   +E++SH      +  TG  L    +F+  +    ++ L       
Sbjct: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4638

Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
             EK +  L     R R L    + A+QF     +   WL E    LDSE ++ +  +  +
Sbjct: 4639 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4695

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
              L + +  ++ L A     +   +T   L+ + +   ++ K+   L  +R+    +  +
Sbjct: 4696 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755

Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
            +  R + L+E L       + L  L+D     +   AE Q    D++ V  L +   AF+
Sbjct: 4756 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4815

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
            KE+     + V AL++ A  L  G+      ++ Q   +   WE +     ++   L AA
Sbjct: 4816 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4874

Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
                      VH+  +  AE +  ++    L   ED      ++RTL  QH+   ++LE 
Sbjct: 4875 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 4928

Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
               E+ +  T    +  L    P  +  ++     ++A+ +E   W  Q     A   A 
Sbjct: 4929 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4986

Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
            L   QEL       L WA+        E + +++   + L+ +H+   +E+
Sbjct: 4987 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037



 Score =  209 bits (531), Expect = 5e-53
 Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           ++Q+KTFTKWIN      +    + +LY +L DG +L+ LLE++SG+ LP   +GR+R H
Sbjct: 75  KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 131

Query: 79  FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            L+N   AL +L R +V +  I  ++I DG+  L LGLIW IIL FQIS I +  E    
Sbjct: 132 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 191

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
           SA     KE LL+W Q+ T  Y  +   +F+  W DG  FNA+IH +RPDL+D  ++   
Sbjct: 192 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 246

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
             L NL  AF VAE ++G+ +LLDPEDV  + PDE+S++TYVS  Y    ++ +G     
Sbjct: 247 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 303

Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                 +   + E+   +Y+ +V  L++WI      +  R FP++   ++ L   +  F+
Sbjct: 304 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 357

Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
             E PP+  ++   + L   L+  ++    +     +G    ++ + W  L  A   R +
Sbjct: 358 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 414

Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
           AL+  + +L+ L+ +A R Q  + + E  L  A   L                      L
Sbjct: 415 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 458

Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
           E+G+     +FQ  AEIA  + +       +   RQ  + V  Q L+     Q  Q+  +
Sbjct: 459 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 503

Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
           Q V  L  E+ A  ++   +    R     Q    +  + Q  +   AQ + H +  S L
Sbjct: 504 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 562

Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
            Q  T  L SS  TS                                 VE    +   L 
Sbjct: 563 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 622

Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
           Q+++ L+     + +LL+Q L   E  ++  ++   W+ E   ++     G DL  +   
Sbjct: 623 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 677

Query: 643 LQKHKALEAEVHR 655
           L+ HK     VHR
Sbjct: 678 LENHK----NVHR 686



 Score =  203 bits (516), Expect = 3e-51
 Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)

Query: 872  ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
            + Q WL+ +     +  P   + D LE +   +++F   L     ++ +  +  E L  +
Sbjct: 2811 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2870

Query: 929  YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
              G+    +Q Q   +   W       +E+  +L  S+E     +E   T        Q 
Sbjct: 2871 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2930

Query: 980  QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
             L ++      L P   E++   L+  QK+         +L    + L SV    +E   
Sbjct: 2931 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2987

Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
             E++ L  +V+            L+ + ++ +E  +V++ ++RQ +    Q  + +S   
Sbjct: 2988 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3047

Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
              ++      L++++ S+        L+   DL + +           AQ   + A D  
Sbjct: 3048 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3090

Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
             + +V   +  + Q+   L    +++  +L+  L+ +  F   +    +  A       L
Sbjct: 3091 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3148

Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
            D++    R+A +L +Q       L  L    EAL A  +            +   P    
Sbjct: 3149 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3204

Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
            ++  L+++  Q  +L  R++ R  Q+  +++ L+E+   + E   L+Q  EE     +  
Sbjct: 3205 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3262

Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
            P G         L   K  +  E E L  ++  + +  +G+ L+  + +    + ++  L
Sbjct: 3263 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3320

Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
              + ++W+ LN+K+ +R  +LQ+A           E LL  + D +E +  Q   + +  
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380

Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
                 ++  + LQ+     +S    +  +   +A+ A   A    IL++      R E L
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3439

Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
                  R  QL+     + + H+     N  L+ + + + +  P   T+     + +  +
Sbjct: 3440 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3497

Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
            HK L+ ++  H   + + +S G+SL      + + +V+   +    W  E++    +R++
Sbjct: 3498 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3557

Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
             LQQA+   + F  D  EL  W   V +K   +S +DY  +    + + LR++ +   L+
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617

Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
            ++       + +E L QT    TG EV    ++   ++ R ++  +   ++A T ++ L+
Sbjct: 3618 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673

Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
               RLH      E+L  WL   +      E+     E A     +  + + + +     +
Sbjct: 3674 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730

Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
             +   ++ +LLE            MV +  +  +     + +  +    A+  ++   + 
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790

Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
                L  +T+ ++K  SL  ++  +     AQL+  +    E++  +  + +L+++  ++
Sbjct: 3791 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3849

Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
               C   +  +++++   V + +  + +   +R  QLERA+ L+ +F     +   W   
Sbjct: 3850 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3909

Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
             +  + Q+   + E  +   +   H+ LR         ++   K   Q  +L        
Sbjct: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3969

Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            Q+  +AA T   +++E+++                 D+ DQ+ ++  R  ERL   +Q  
Sbjct: 3970 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4026

Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
                E  ++ E+I   + VS+    L    E ++Q   + E  +      DK  +A   +
Sbjct: 4027 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4083

Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
             K  +   + + +  L++ R    + V ELAE +    H SL++          +D+I  
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4135

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
              + L++P + P  ++ + +     +    E+   +E +  V   G  L+A    P    
Sbjct: 4136 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4190

Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
            V + +  L   W+ L +A   R  +LE+  +  +++   +     W+     K+ ++  +
Sbjct: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250

Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
            G DLE   Q    L++F+  +    +    +   ++L L+ K  +  +   +     +L 
Sbjct: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4309

Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
              W S    ++  Q +LEGA L +      LD +   +   E L+ +    G D ++++ 
Sbjct: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369

Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
             L KH  L+ +V   Q+ VE++ +    L + S  E A  L+++ + + + W  +  + +
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429

Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
            +R++ LD AL QA+     +++L   L   +  R  + + P    P  A+  L  H E  
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4487

Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
            A  ++  ++       GQQ+L A  P S++  I Q +  L+++  S+E    E + +L++
Sbjct: 4488 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4546

Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
            AL L + F +S++    WL   E +L       P   ++ +L+   +HK+  +  EV + 
Sbjct: 4547 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4602

Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
            +   +E    G H     + Q  +       ++  R E + ++   R   L++ R + + 
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662

Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
            F +   ++  WL   EK+L +  E   D   +  QL + + FQ  L A         R G
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722

Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
            + L +    A +   + + L EL   W  +   S ++  KL++A   + +   +++ L +
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782

Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
            WL  +E +L    P  G  +  V  L+   +  +  + K+    +AL   A+  +     
Sbjct: 4783 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4841

Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
             +  V+ Q + L  R++++      ++T LEA        R A+E  + V   L  LA A
Sbjct: 4842 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 4895

Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
            +              A+R L +QH+    ++    A        G  ++   H       
Sbjct: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
             H +     + E+ +A  +    R    L      Q+ L  LL    W        D E 
Sbjct: 4956 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5015

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
            +    E  +AL+   +    ++    P ++++ +T
Sbjct: 5016 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5050



 Score =  150 bits (380), Expect = 2e-35
 Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)

Query: 253  QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
            +T+ +++ +   QLQE  L   +++  +  LL W+ + + +L A   P S        A 
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3378

Query: 313  FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
            F + + Q +  +L QR     L  R  T   ++ +  +     E     ++ +  + L+ 
Sbjct: 3379 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3434

Query: 371  AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
               A     + R  QL+ +  +A++F         +L   E+ L          + +E  
Sbjct: 3435 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3494

Query: 431  VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
            + +   LE  I+           I   L+        D+ + + + +  W   +Q     
Sbjct: 3495 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3554

Query: 491  RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
            R ++            +  + L+  +     +L +L     ST    +    + +LQ   
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614

Query: 542  LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            LL  Q      +V        E L  + G  V ++Q K   +    + +  L       L
Sbjct: 3615 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668

Query: 601  EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
            EQ LQ A  L +  EE   WL +    +         G + SQ   A  + K L+ E   
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3725

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
            ++A+   L      L    P    +  E+  A     ++L+   +  +   +  A+L  Q
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3785

Query: 715  YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
             F  AA+A  SW+ E   +  SL      QDQ +A+          +V + F  E+ R +
Sbjct: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3836

Query: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
            +             +   L   G  +         +C      + K  L           
Sbjct: 3837 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 3865

Query: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
                  D + ++Y+++  +   R  +LE A +L   F  +  EL  WL E Q+++ Q   
Sbjct: 3866 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919

Query: 889  P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
            P  + +TL   Q ++      +A  K    +++ +  QL +  PG    IQ +       
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3979

Query: 947  WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
            + Q++   +++AV L  ++ +   F  +       L  ++ +L      S+E      Q+
Sbjct: 3980 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4039

Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
            ++ K + ++  +  LQ +   +++ G               ++ +Q +++ +  + + + 
Sbjct: 4040 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097

Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
              V +R  +  +  +  + F  +   L++  +  Q  +R  ++  +D +  ++     + 
Sbjct: 4098 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157

Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
            + EEI   QE L   ++  S+ +AA   PD   V  ++  L      L   W+ R   L+
Sbjct: 4158 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4217

Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
            E   +Q   +  DG  A       W+         +  +G D+      +++ ++F    
Sbjct: 4218 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271

Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
                   E L    E L++  ++    HTV++ L  ++  W  L+ R   R+ +L  A L
Sbjct: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331

Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
             L +++  + EL+ W+   +GL++  +P G     ++  L +H   ++++LA +  VEA+
Sbjct: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391

Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
             + G +L+     G+E  ++Q +L+ L  +W+ +  K  +R  +L  A +Q +    +++
Sbjct: 4392 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4450

Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
            D ++ L   E  L +S+    L  + + Q   H ++    E++  T  + M     M   
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4510

Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
               +A   I ++      + E ++  L  R  +L+ ++ L    H S  + ++W+ +   
Sbjct: 4511 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4570

Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
              +  S     L+       +HK    EV +H+ Q+  +  +G  L      Q   +++ 
Sbjct: 4571 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4630

Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
                ++  W ++ +    R + L  A    + F +  S+L  W+EE ++ L S  +   D
Sbjct: 4631 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4690

Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
                   + +H+  Q+ L    S  +  ++T ++L          +    +   LR++  
Sbjct: 4691 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4750

Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
             +   +  R  +LE  L    +F    + L  WL   +      + +  D +  ++L   
Sbjct: 4751 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4810

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
               FQ ++   +  V A +  A  L+E        V+ + Q+L T W  +  L+ ++   
Sbjct: 4811 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4870

Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
               ALR  E    V   LLE L +  E+       +  D   L   +  H+   ++L   
Sbjct: 4871 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4929

Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
              +L +       V  +C       ++      + +     AWA    +  Q+R     A
Sbjct: 4930 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 4985

Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
             L+A+     A+  +  WA     D   E   QE       ++ HQ    E+  ++
Sbjct: 4986 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5041



 Score =  139 bits (349), Expect = 7e-32
 Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)

Query: 824  DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
            D   +   + + Q    +  + +  L      RL      F       EL+ +  KQ  L
Sbjct: 1584 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1643

Query: 884  LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
             + +Q  A  L  +    ENFL     G+ L  E  +  EQ       N  +I+ +Q  L
Sbjct: 1644 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1696

Query: 944  SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
                 + E L +     +    E  + +++   ++ ++ ++L  L  +   S        
Sbjct: 1697 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1751

Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
               + K ++ +   HF +     ++  + E  G      + GQV T Q  L Q  ++V  
Sbjct: 1752 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809

Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
            +     ++ QA    TQ+ Q  L++  Q L   E  + Q   KE+ V   +A   L E +
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 1866

Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
              ++  H  QE L++ DA           D  E  + L+   Q  QEL+ L         
Sbjct: 1867 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 1912

Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
            L   L+ QK       F+    +H+  L ++   G  V EA     + R+ G+ + T   
Sbjct: 1913 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 1964

Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
              E  R   H     +S +   + +   L+ +  ++   +  S      LLA LQ  E  
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2018

Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
               A   + + E     A +P    +N+ + L+  +A + ++ + +  VE L++    LL
Sbjct: 2019 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2068

Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
              R      + DIQ  L  +  ++E L++ + ER ++LQ       L R L  QD  +++
Sbjct: 2069 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2123

Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
                G ++SS  E GQ   +S  LQ    ++  LE +     + + A+            
Sbjct: 2124 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2183

Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
             S A  + A     S    E + KH   L  ++       L    S +L  F       L
Sbjct: 2184 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2243

Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
            + V   +P    T  ++ +  + S   +HK+           ++ + S  + +++ G P 
Sbjct: 2244 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2291

Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
             + +V E+   L   + E+E       EA   C +Q   FQ   + V  L+ W++E    
Sbjct: 2292 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2348

Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
                +P   + D G+    T +L  K      E+    +S   L      +T P      
Sbjct: 2349 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2408

Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
                                        + +    +     +    L++  A  + +L  
Sbjct: 2409 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2467

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
              +L +   E+  +  WL    + A   +      D E       +   F+ +++    +
Sbjct: 2468 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2525

Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
            V   +     LLE        P  +Q   ++ + W EL +LT  R   L ++   L   +
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2585

Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
             +   L Q    +E   S+   ++ D   L  Q +  Q L +E   T +   E L  AG+
Sbjct: 2586 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2644

Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
                 PG        V+++  AVTQ W  L  ++  R   +++A + + ++++ +R  + 
Sbjct: 2645 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2704

Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
              + +   L    + S  P +   +L   Q ++ E++  +K  + A  L +   AL+   
Sbjct: 2705 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2764

Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
                E+  +L  +      V Q      + LQ+        ++  R  +  +   +E   
Sbjct: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824

Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
            K+  + + ++ +E LI+ H+ F K LTAQ    E  + E    L + +  ++  + LQ  
Sbjct: 2825 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2884

Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
                       +VKE       +L  +L    + +       WI      L+E     D 
Sbjct: 2885 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 2941

Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
             +    + K ++ + E+  H  ++  +     +LL+        V+   + L +  + + 
Sbjct: 2942 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001

Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
            + +  +   LE+  + F EF +    ++  +Q  + ++++ D LG               
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061

Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
                Q L+H + L +RL +     A D+ G       SD+ LQ        V+ I Q  S
Sbjct: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3107

Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
             L+             QQ  E    +    + + +    I  +E   Q  +   +L+S+ 
Sbjct: 3108 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3152

Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
             + R  E L+++   I+A ++ LE          + C       + SP+   G++   + 
Sbjct: 3153 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3211

Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
            +++   +L  RAQ R E ++  + + ++  + L+E  +  Q+     ++        E  
Sbjct: 3212 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271

Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
                 M +  Q  K E++            GQ L+ +    +S       GLE +L  + 
Sbjct: 3272 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3324

Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
              W+       +   QLQ+A L    F  ++E +  W+   E+ +A++    P A  + +
Sbjct: 3325 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3382

Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
               + + K+L+  L+ +   +  ++     +     P +    L +   +  R EAL  +
Sbjct: 3383 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3442

Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
            A TR  +LE +  + Q F +  + +  WL   EK LV  E      + L  Q+ + +  +
Sbjct: 3443 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3502

Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
             + ++ + H  Q +       +       + +Q +L+     + E+Q+ S  +   LQ+A
Sbjct: 3503 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3562

Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
             C A        EL NWL  +  +L   +V   +  G+ +     R L+  +  + +  +
Sbjct: 3563 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3622

Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
                  QA +     L Q   ++              +Q++  A++AR      ++D   
Sbjct: 3623 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3657

Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
                   KL    A+   Q+L   R L   H+ L       E E+ S+E  T+V+ G   
Sbjct: 3658 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3706

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
                       E A++ Q   K    L+ EA   + LL    E    L EL+    W A 
Sbjct: 3707 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3749

Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
             G   + +ED       +  + +++E    +++A   R ++  Q A              
Sbjct: 3750 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3792

Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
             A+L  + E   +L+   + R    Q   QL   +  T+ +             +D   D
Sbjct: 3793 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3841

Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
            L  VK   +   A  +E +   + K+  + K   T+ +    RY  ++  +S +   WE 
Sbjct: 3842 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3899

Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
             ++     TE           Q   ++L     E               ++R  Q++HR+
Sbjct: 3900 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 3936

Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
            L   +   +  + ++     +L +L P     + +   A  TL ++ +E          +
Sbjct: 3937 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3996

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             ++Q+ Q H  + +  E L    ER  L     ++ +V   ++ + +++ +  ++ + + 
Sbjct: 3997 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4054

Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
              + L+Q G++++  S     +++   + ++ +L ++   W
Sbjct: 4055 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4093



 Score =  136 bits (342), Expect = 4e-31
 Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)

Query: 469  VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
            VA RQ+E   + Q +   L Q + + +   +A +     VE   +Q   EELQ+  + +A
Sbjct: 1592 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1651

Query: 526  CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
              Q LAEVV           E L + D       L EA++     ++    Q   ELD  
Sbjct: 1652 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1708

Query: 568  LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
            + T+++    K   + QL++S   +                     + ++EQ     Q  
Sbjct: 1709 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1768

Query: 608  EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
            +      EE+       +   +  +G     +    QK KA  E  + +HQAV +     
Sbjct: 1769 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1828

Query: 667  GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
               L  +     P+  E+ +      ++     +    +       LQ     + AD  E
Sbjct: 1829 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 1888

Query: 722  AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
               WL++    LE    G D      T L+R       + +   +LR +   G      A
Sbjct: 1889 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 1948

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                                     SC    G         + D       + +  DH +
Sbjct: 1949 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 1976

Query: 841  QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
              + SL +   +    L++ +  +     +SCG                          L
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2036

Query: 874  QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
            Q  LE+   L  ++  Q   +E ++   E  L A         ++  + + +  RY   S
Sbjct: 2037 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2096

Query: 934  TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
              +  + E+L               + L  S+ V   L E       +   L +   +  
Sbjct: 2097 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142

Query: 994  GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
             S+     ALQ    K ++LE+ +   QS +  + E      +        +LQ  +K +
Sbjct: 2143 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197

Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
              + ++ + +  ET A+   L+   +L    +E +Q  L +K     EV V       L 
Sbjct: 2198 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2257

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
            +  Q+   E    ++ L+ L +  + ++      S  +P+   ++ ++   L   +++ +
Sbjct: 2258 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2311

Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
              ++E  E +     ++D F     + ++W+                ++LG+ + +   L
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2371

Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
                      +Q+    G     L+S +   A+A+ A   G  ++  +  A +T      
Sbjct: 2372 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2431

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
            + L SI+   T +    E     L   +A L     +LQ+ +++ + +MQW+++    A 
Sbjct: 2432 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2491

Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
                 P+      ++T ++++++ E+EL      V+ L+    ELL   P   E  + + 
Sbjct: 2492 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2551

Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
             L  + SKW+ LN+   +R  +L+++      L Q Q  + QL+Q  +E  L  S  G  
Sbjct: 2552 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2608

Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
                  L  + QQ++    E  T   +   L +   G+ + P         + E+     
Sbjct: 2609 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668

Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
            ++ + L G L+ R   + QA V+  Q+  L        S+++    +       P +  +
Sbjct: 2669 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2728

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
             L  AQ + ++ ++ + ++K  Q   + +  L     L A    Q + I++      Q+ 
Sbjct: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2788

Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
            E H   L+ AC +  Q  Q +  FQ + LD  + E      +  K  ++ S     +D+ 
Sbjct: 2789 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847

Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
            +   A   +  K  A  E L +     E+     Q  T          +V E++  ++E 
Sbjct: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2907

Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
            L + L+                  L+E+    D  E E ++ +L    +E +   G +  
Sbjct: 2908 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967

Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
                A    S+ E D E                    H+   C      KF +FQ +V  
Sbjct: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3026

Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
             S+R   C   A+  L+   S G          M++ +Q+ LQ            A   +
Sbjct: 3027 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3083

Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
             E + ++G    L   ET  + H  L +   QV EK + L           N  R++   
Sbjct: 3084 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3140

Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
                + +L S   + R+    ++Q          L+ L+ +     K C          P
Sbjct: 3141 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3200

Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
                +++  +A+++    L  R + R  Q+E   + L  F + +++++     + Q  + 
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3256

Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
             E SQ P     +    Q      + + E+E  +   Q    LGQ  + +A   T     
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3311

Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
              + L+   D V   W    +++ Q   Q Q  L  CGR ++ L +        +E+   
Sbjct: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371

Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
                 +  + V+  I++ ++  ++L  +      ++   E++ T   P    ++  +L +
Sbjct: 3372 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3431

Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
            L  R   +   AE+R   L   S++   F +      +W+    ++L    P G    KL
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3491

Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
             + + +H+A E ++  H + +      G++L   S     ++ Q      + W       
Sbjct: 3492 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551

Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
                 E L+QA+       ED    + +L  V        +K  K++V D   +     Q
Sbjct: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3604

Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
               R+ +         V  A +  +      LK    +EV II  +   +  R+      
Sbjct: 3605 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660

Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
                 + LE AL+    +H    EL     ++ E E L       K  E+ Q  +R  +E
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3718

Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
            L++E    +A ++SL      L +  P  A  GL     E  E +  +     ++ E +D
Sbjct: 3719 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778

Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
            A  L   Q  QA   EL    +  +  M          +    L+  +    E+    D 
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838

Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
            I     +G +++TA        +++ L  + +   ++     E  LQL++A  L   F  
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898

Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
            + E++  WL   +  ++   L  P    E L     +H+ L   +      I  +  T  
Sbjct: 3899 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3956

Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
             L +    E  S   +  A       +      R   L+E          ++   L+  +
Sbjct: 3957 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016

Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
             +   LR+   ++ E        +  Q+ + +N   +++      + L++ G+ ++   G
Sbjct: 4017 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4071

Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
            G     +++A+Q++L+++  +W  +    +++ AKL           C+ + L  ++++ 
Sbjct: 4072 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4131

Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
            ++++  +E     P+V +      E +     G Q EL+  ++    +  A  G+    +
Sbjct: 4132 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4190

Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
                     V++    L   + SL +  ++R   L EA    +++         WV    
Sbjct: 4191 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4241

Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
              LA+    G  L  V+   E+          Q +E E  +H+A  L + V     K   
Sbjct: 4242 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4298

Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
                  H V   + +L+     L      R+  L+ A  A  QF   L E  +WL    G
Sbjct: 4299 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4352

Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
             + + + +G   +A +  L +    + D+ A    +E + +    L+ES    E+  +  
Sbjct: 4353 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412

Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
            +L+ + +    +L + E R              HG  E LQ    + E  LL +      
Sbjct: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4472

Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
                 +     +E     E K + ++  +Q  GQ  +    K A T          +I  
Sbjct: 4473 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4521

Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
              + ++  WE ++  +  R     E L  A E H+  Q    +    Q +  L       
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4579

Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
              L +V     +H+    E+ +  +++  L      L          L K     VQ  W
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639

Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
              +  +  ERG+ L  A  +   F     +L+ W +E ++   SE E+A D    +  L 
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699

Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
            QH+E  + +           + G+ L + +      +     +L+  L EL + W
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4749



 Score =  132 bits (331), Expect = 8e-30
 Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)

Query: 306  MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
            + Q L  F +F+ +E  P   ++     L   L  +         L H+   L +++  W
Sbjct: 3271 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3327

Query: 366  AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
              L    A R+  LQ+ LL          RFQ       S++ D E+++   + P A   
Sbjct: 3328 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380

Query: 426  TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
             V+A +Q   +L+           ++ +EG +    AE AD ++         + ++   
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3431

Query: 476  VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
            +  RW+ LL   + + +Q+  +  V     E +E  +  L  +++  R   C   G Q +
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3489

Query: 532  EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
            ++ E + +H  LE  +  H  H+            S+G S++VL +   K    ++L  S
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3541

Query: 589  LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
             V  +       +R  LL+Q L  A+     E E   WL E   ++   ++    ++   
Sbjct: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601

Query: 642  ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
              Q   + L+ ++   +      +  G +L       +   G+    +Q   + ++    
Sbjct: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3651

Query: 701  GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
               AR +    +    A   E A  L  R  S     C         LL    ++ +   
Sbjct: 3652 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3708

Query: 761  AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
            A  A++R  E +  A + +A L ++N   S   E +                  W+    
Sbjct: 3709 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3751

Query: 821  AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
             E     D        D ++Q  E + A A LR  + ++A        +  EL  W+   
Sbjct: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3801

Query: 878  EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
            EK+ + L  ++ + D         + F   +   K +  ++  S  ++         Q +
Sbjct: 3802 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3861

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
            +++ +++ + +  +  +  E+ +QL  +  + +      +E  P   + + ++ QL A  
Sbjct: 3862 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 3919

Query: 993  PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
            P    +T    Q    Q + L+ E + H   +     ++ E    E   +Q +      L
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3979

Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
              Q++E V +RA    E  ++ + F  +  Q+L   E +  +LR    +S +V   +  +
Sbjct: 3980 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4039

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
             E++++  ++   Q   + L  + + M A      +++  + + +  +  ++  +WE   
Sbjct: 4040 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4097

Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
                +R+  L + +EL +KF  +      T  + Q ++  L++ G             E 
Sbjct: 4098 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157

Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
            +RE +  LQ+  +   ++  LG  +E + A GE       P    V++ +  + + W  L
Sbjct: 4158 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4205

Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
                + R  +L  ++Q     QD +  +  W++   G +A+  P G     + Q ++  +
Sbjct: 4206 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4265

Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
              +SE    +  +E L     ELL ++   + D   +Q  L  L+  W++L  ++  R  
Sbjct: 4266 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4324

Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
            +L+ A    GQ +  L +L      L   EG L   +  G D ++ +    +H  L+++ 
Sbjct: 4325 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381

Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
                + + A+    + +  S A  EE      +LE+L             R  QL  ++ 
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440

Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
              +  H    +L  W+ +   H        G P +  E LN        H E+    +A 
Sbjct: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4493

Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
            +   + ++  G+ + A     A+  ++Q    L+  W  +E     R   L++A+     
Sbjct: 4494 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553

Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
            F + + +   W+ +      V+SR     +    + I++H+    E+  +   + ELD+T
Sbjct: 4554 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4612

Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
               L      ++Q VV         Q R  + ++ L E   + D   +   + HE   + 
Sbjct: 4613 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4669

Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
              L  WL   +++      +  DP+       +  +FQ  +               SL E
Sbjct: 4670 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727

Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
            +   A   ++      +L+  W  +   +  R + L +         D L+ L       
Sbjct: 4728 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4787

Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
            E   +    V  D+  +   + +H+  ++EL      +Q L  +A   ++L  G +  + 
Sbjct: 4788 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4844

Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
             V+ + Q ++  W  +      ++ +LE A R    F + V     W A   Q L+    
Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4904

Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
              +       L   H+    +LE +     +AT +G   L      +    +    +   
Sbjct: 4905 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
            R +    WA++ ++  A     L  ++   LE +LA  + +  T        +   +EEV
Sbjct: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5023

Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
            + LI +H+ F++ +T   +K+  + +  KT +R R  D  P  LQ  + V +   +    
Sbjct: 5024 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5077

Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
              AS L  S +Q   + ++         W Q W   L+      D  D+L+ L +   F+
Sbjct: 5078 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5137

Query: 2161 AEV 2163
             ++
Sbjct: 5138 FDI 5140



 Score =  110 bits (275), Expect = 3e-23
 Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)

Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
            ++  L Q +T ++  +  V +L  WV+E +  +   ++G D  +    +  H+ +   + 
Sbjct: 630  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689

Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
             + SS++E   +   +T P ++   +++   RL  Q   L   +  ++R L+    LH F
Sbjct: 690  EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 744

Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
            +  A +   WL ++K+  +      E   +        A+   +++   + + + + +AE
Sbjct: 745  VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 803

Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
             LL   H A   +   +  +QT WS + +L Q     +++         D  E    ++ 
Sbjct: 804  QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 863

Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
               ++    +   C   + +   + L +E   +  + +ELL+    +  L          
Sbjct: 864  LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 907

Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
                 + +A  ++Q +       L+ +  +     A+ DY           Q+E +  + 
Sbjct: 908  -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 948

Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
                L  ++H   RA+       W+  +  G +A++         P KE  +    ++ Q
Sbjct: 949  DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 998

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
               V   W      +++       + E   ++ I A+   S+KT   G   + +  L  +
Sbjct: 999  YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1055

Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
             E FL     +D +E+ +       +  +  +      Q  ++  E  E        +L 
Sbjct: 1056 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1108

Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
            ++       + E+      +Q++ P+   DL + +  + + +  + E++  ++ + ++  
Sbjct: 1109 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1168

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            K E   +Q+   +   + R + L    +++ Q  ++    ++  +     L+    AEA 
Sbjct: 1169 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1227

Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
            ++  E K+           N+ +L   L+   Q R  + E R   ++  D +  A  ++I
Sbjct: 1228 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1282

Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
            SD   +       +     ++  QL  RW + H        Q++  L             
Sbjct: 1283 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1322

Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
                            +DLE + + L+ + +     HP+   ++ +E    ++ +  PE 
Sbjct: 1323 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1363

Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
            +  L  +  QQ++  S  +++       QK  E   A  +  +LQ M    +V +Q+   
Sbjct: 1364 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1420

Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
                    +SPV+ RRM         E +D  T   +L     Q +  AG          
Sbjct: 1421 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1464

Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
            L  LE+E  SLE   +EH   +++A ELQ ++S++ K              ++ + S+E 
Sbjct: 1465 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1521

Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
            S   E L + L  ++  L KH  KM + +      ++  L+ +   L      + Q +  
Sbjct: 1522 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1581

Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
                 +  K    RQ    +   E+L+ +   L  +        E  L+  +E  +    
Sbjct: 1582 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1629

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
            T  L     KQ+  Q ++  S     E+ +  +  L + G   S+     I+++L E   
Sbjct: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689

Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
               +L    + S+K++ K+         +K     +L  S  ++EN   WL  ++ +  R
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749

Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
            A T                     +G+     G LL          TQ  L     K   
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809

Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
            Q E ++ Q QA +           ++G  L+ + +E+ ++ ++  K     +L E  ++ 
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869

Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
            +     +  L KF  D  E   W+Q+ +  L   +     ++ +    ++ ++   ++ S
Sbjct: 1870 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929

Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
            H+   R +  +G ++++A    +     +V          ++L+ A    R+  ++  +L
Sbjct: 1930 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1989

Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
                ++         +A   L       ++    H +E      + L R+LE TK     
Sbjct: 1990 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2049

Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
            + +    +E+L++TA  LL++R +  P    +   L  +   + +L +    R   LQ  
Sbjct: 2050 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2109

Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
            L      ++ L  +LD W+    ++ + Q          QD+    ++ E+  A R    
Sbjct: 2110 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2164

Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
               Q+ + A+  K+   +E   P     +QA+   + A   R  +A     E LA   E 
Sbjct: 2165 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2218

Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
               V  F+  + +LQ  ++ KT AL + +  G  ++ +    Q       +H++    L 
Sbjct: 2219 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2278

Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
            ++ KE++                P   A V E    L  K +E    + +  +       
Sbjct: 2279 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2326

Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
               AF    + L +W    +E      + +   GAE L    E+  +   +  L+  +++
Sbjct: 2327 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2383

Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
            +     +   + +SA  T             +   EG     EE WA +        GL 
Sbjct: 2384 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2435

Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
             +++ +                 D  H   D+ LLL       +  L KL  AQEE  A 
Sbjct: 2436 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479

Query: 3444 MQ 3445
            MQ
Sbjct: 2480 MQ 2481



 Score =  108 bits (270), Expect = 1e-22
 Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)

Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
            +VAS + +L  EHQ +L  +   Q R +     SQ        D  ++   + V  Q  Q
Sbjct: 1033 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1089

Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
            EL    E+ +Q   E      +  EV        N +          L  D+L E V   
Sbjct: 1090 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1146

Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
                +  +E  RL   LG           +   S   +  T+R +L  +     ++   S
Sbjct: 1147 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1204

Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
                 +L  ++ L       AE +  + E  L         + NI   +   +   SE+ 
Sbjct: 1205 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1263

Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
              R+   AL+    EL   +    E  +T             +   L  +W+ ++ ++  
Sbjct: 1264 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1320

Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
            R  +L+  G+  +  R     L D  +Q+E  +  +Q ++       + +L ++ + L S
Sbjct: 1321 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1379

Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
            E     +KM      A   +A+    E      R +   Q    ++  ++Q+S +L   +
Sbjct: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1439

Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
            F  L     + V         T Y +    + + L  + K L+ E K H       Q  V
Sbjct: 1440 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1493

Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
              +  + +    +G P         +E+     +L  A +          T Q +     
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1538

Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
                       L    D   DE     L  + + LQE   + +S  E L Q  ++ T  +
Sbjct: 1539 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1584

Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
            V  ++++V ER +E    LQ     L  T +R +         +GT+ L ++  + E+LQ
Sbjct: 1585 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644

Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
              +    QA             + GE L ++ +  +      AK + +            
Sbjct: 1645 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1704

Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
                    ++  +++VAA + L ES  +  +     +    +D + A ++  ++ +  G 
Sbjct: 1705 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1763

Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
              ++ +          V+ +LLE  T V  +  +   N+ +    ++AQ        + +
Sbjct: 1764 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1821

Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            +   +  Q LLE  G  Q L P  +    +  ++        L    ++ +        L
Sbjct: 1822 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1879

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
             +F     ++  W  +  Q+L+  E+  +  +G + KL   +    ++ + +   +  T 
Sbjct: 1880 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1939

Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
             G + L AA + +K             EVQ +L    D+   +Y         L+   ++
Sbjct: 1940 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1999

Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
             +      CG L  + A +  + K  +   +V+  + L R+ E   K L  Q   +    
Sbjct: 2000 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2057

Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
            E+LK      +  R  +L     +Q+ +     R ++L++S   R   L  +L  + S  
Sbjct: 2058 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117

Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
                +  DW+      LKE    P+    L+D +    K+   E ++   +  + ++ +K
Sbjct: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2174

Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
             +  +  + P  A  +  +++ L   + +          ++E+ +  +E  + + +  + 
Sbjct: 2175 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234

Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            +++ K   +   D+ G+D+    Q ++    EF  +     V  + ++ IS   L     
Sbjct: 2235 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2289

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
             P +  ++ ++ + L+ ++      +   ++ +    E      VL + L +  K   +K
Sbjct: 2290 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2348

Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
              ++Q    A D GK LE  ++L  K      E+  +     SL   +  +   +   A 
Sbjct: 2349 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2408

Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
                G     +  A   E +W                         L+ +  +    L  
Sbjct: 2409 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2468

Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
            L +AQ+  + + + L    +   +   +PAP      +  +E+++  +AEL    + +  
Sbjct: 2469 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2528

Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
             +    +LL          R      +Q L+ ++  WQE +QL +  QQ LE     L  
Sbjct: 2529 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2583

Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
            F +   ++++WL  KE  ++  G   PL+    +L     + ++L  +   +  +   L 
Sbjct: 2584 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640

Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
            A  +G+    G  P  +  +    A + +K ++L  Q   R   +++      Q Q+ L+
Sbjct: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700

Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
               +  + L  K   +L       AM   QL+  Q  + E+     Q    Q L  +   
Sbjct: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2759

Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
            L++  +  +E +  +LE +   + +++  ++  V  LQ AC  + + ++   + + WL+ 
Sbjct: 2760 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2818

Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
              E + ++  +   L  +  L+   ++    +  ++   E  + + +   ++        
Sbjct: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2878

Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
            ++ Q   +   + +  + ++ER   L E+    LK+    +    W+   Q  L  +   
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938

Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
             D  +  +++  L    ++L+ EM  H  +  ++  T   L+         V    + L 
Sbjct: 2939 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 2994

Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
            + +  +  +   ++  L+   Q+ ++F     E+   L      LD  D   S   +   
Sbjct: 2995 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3054

Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            L  L+  ++ L+A   +++  ++ A   ++E+  +  +  VL Q++ + + H+ L ++ +
Sbjct: 3055 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3114

Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
             +   L+ +LQ        + ++  +    D  L + A        G+D E ++  +E  
Sbjct: 3115 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3168

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
             AF K++++L  +   A +     L        P +   +  +EA  +   Q  K     
Sbjct: 3169 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3223

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
             A   +V    +   E   +++E + L+ K E+   S   V     T+ QQ        +
Sbjct: 3224 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3283

Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
             E+E ++ +    Q +   LGQ  +  AA           L  V   W TL  K  +R  
Sbjct: 3284 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3339

Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
             L +A      F    + LL+W  + +EL ++++         +   Q ++L Q + + R
Sbjct: 3340 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3399

Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
                + +++EG+++   +      ++ + L  L+ R +  L +A     Q    S   Q+
Sbjct: 3400 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459

Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
              + LE    WL   E  L+  +  G   S +E  + +H+ LE                 
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3519

Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
               K+L+++E+K     K +  Q   ++ QE    R+
Sbjct: 3520 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)

Query: 246  CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
            CS   + Q+++++L K+L              LQL+  + L  Q+ +   +L  W+ E Q
Sbjct: 3853 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3911

Query: 292  MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
              +        LPA    L   T+ + QE+  +L++      L+   +  +   N+    
Sbjct: 3912 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 3957

Query: 349  --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
                 P EG  + E    +   +   +   + +++R + L    + + +F  K    +  
Sbjct: 3958 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4011

Query: 407  LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
            L+  E+++++ R PP+  A VE   +++   +   +  E + Q L E      +E     
Sbjct: 4012 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4070

Query: 465  -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
                   S   V  + +++   W+ +   ++ +  ++ D+  +        +SL+  ++ 
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4130

Query: 510  ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
                + +L++P    +  +Q  E  E ++   D L+ ++       S L     E D   
Sbjct: 4131 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4189

Query: 569  GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
                 +++     L     SL    + R   LE+ +Q A ++    +    W+   G ++
Sbjct: 4190 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4244

Query: 628  GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
             + + +G DL  +   +++ K  ++E ++ Q + ++ +    +L  ++   + D     +
Sbjct: 4245 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4303

Query: 687  AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
             +      W  L+ R++ R  +L+ ALL L  F  A  E  +WL      L E+   G D
Sbjct: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363

Query: 742  QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
              A E  L +H  L+  + A  + +                     A++  G  L     
Sbjct: 4364 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4403

Query: 802  WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
              EAS                         +    + L+Q ++++    + R+ +L+ A+
Sbjct: 4404 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439

Query: 862  -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
                GF     +LQ WL   E+  +  + +    +T +     +     A    +  +  
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4499

Query: 918  VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
            +    +Q+  R P ++ T I +    L ++W  +E    E+  +L    E  +   E   
Sbjct: 4500 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4556

Query: 977  TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
            +     + L Q E     A +P    DT    Q+ + K    E   H  +  ++++++ G
Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4613

Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
                 +++ Q    ++  + ++Q   ++V +++ +R R   + + R + F +   +L+ W
Sbjct: 4614 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4673

Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
             E  +  L S+ E++ D    +  L +H++  + +   H   +   +     +   +L  
Sbjct: 4674 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4732

Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
             D+ ++ + L  L  +   +     +RQ  L+E L     G+  D   A       WL+ 
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4786

Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
                L E      D+   ++L+  H+ F + L       +AL+    +L++     +  V
Sbjct: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4846

Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
            + Q+Q +  +W  +   S  ++ +L A+L Q +E+   V  L++W+ E +  +  H    
Sbjct: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4906

Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
               + L+TL  +H+    +L   R  +     +G  +L+   C  + I T        W 
Sbjct: 4907 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 4959

Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
             + R   E  + L  A Q +Q L      L   +E LE L   LQ +ET    +  + + 
Sbjct: 4960 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017

Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
               Q++E     +A     +  M       P + + T+ + RR      LQ H+ +
Sbjct: 5018 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5067



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)

Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
            Q   ++E  ++ +QD    +++++  L  +E G DL S +   + H+ +     E ES  
Sbjct: 636  QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 695

Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
              AK++ +   A      P  L   +K L RLE     L       +  ++ LH F   +
Sbjct: 696  KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 748

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
              EL W+ E         ++E           H EL  E+   +  ++ V      L   
Sbjct: 749  TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 808

Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
             HP    I      ++  W+ + + C+   Q +++   + ++F D  E   ++   +  +
Sbjct: 809  NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 868

Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
              R Y  D ++++     L+ +    +EEL  Y S++  L   A+T+
Sbjct: 869  -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 914



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)

Query: 209  VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
            V E +  + +LL+        P  + ++T +   +   ++L    T+ R+      +L+E
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2576

Query: 269  TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
            +    TQ++ + A L +W+ EK++ +         P+ L   RQ +          KP  
Sbjct: 2577 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2636

Query: 325  LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
             Q   A + +L R     +  + R  +  +   LA ++Q W  L    + R   + Q ++
Sbjct: 2637 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2690

Query: 385  QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
            +  + ++L R    K +  ++ L  +  V     A    L T +   Q +   +  I   
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750

Query: 445  EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
                QAL E    L +E+Y   A+++R+ E +   ++ + Q  +            +  L
Sbjct: 2751 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2795

Query: 505  QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
            Q   A+SHQ +++            +E  +S     +L  +  L++ H      ++A   
Sbjct: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2853

Query: 553  HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
              SH+ ++T     +L     G+    LQ +  T+     +    V+ R   L+++L++A
Sbjct: 2854 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911

Query: 608  -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
             ++    E    W+ +C   +       D ++   ++ K K+L+ E+ +H
Sbjct: 2912 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 2961



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)

Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
            +L   + E    +   + G  L SV +  + H+ + R +E  E  +     +  ++ ++ 
Sbjct: 650  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 704

Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
              AP  L       +++  +A L   ++ + + L      H F+ R    L W  E++E 
Sbjct: 705  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 761

Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
              + + +E      +    H EL +E+ +     + +++  +QL+  +H   A +T    
Sbjct: 762  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 815

Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
             +E     ++  W+   Q C      Q + Q +++  A+   +       DY  ++ D  
Sbjct: 816  -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 867

Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
              + R    ++  ++   K   + +  ME+ E LLQ +       G + T  Q +P
Sbjct: 868  --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 919



 Score = 40.0 bits (92), Expect = 0.042
 Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)

Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
            Q LL W + +Q QL   E   D+ S +  L  H+++   I  ++  L++       M A 
Sbjct: 649  QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 707

Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
              P        L  L  + Q  K+L   R Q        ++    +  F +   N   WL
Sbjct: 708  --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 755

Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
            +    + +  D  E  + + +    H E  R L       ++++   E+L+   HPA  T
Sbjct: 756  NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 815

Query: 1250 VREQLQSIQAQWT 1262
            +     ++Q QW+
Sbjct: 816  IEAYRAAMQTQWS 828


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  222 bits (566), Expect = 5e-57
 Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)

Query: 408  KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
            K+ ++ L++ +A    +++ + AV++L      +L+A   +LP +   Q   +  DI+ +
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2229

Query: 461  EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
             +  S   V  R E++ +   R L    G  + +  M  V S L+E         + Q P
Sbjct: 2230 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2279

Query: 521  ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
              STA       + +++ ++ +LE  ++   + ++ + ++  + ++++  ++   LQAK 
Sbjct: 2280 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2332

Query: 580  RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
            + L+          +   A +E+   + E   N  E+ + +L+   Q +    + G+D++
Sbjct: 2333 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2392

Query: 638  QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
            +++  +Q+  +   E  +H  V   L++   ++S+   P+      E+   +   ++ ++
Sbjct: 2393 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2449

Query: 697  TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
              +  +   + +    L  F    ++  SW++E   + ++    Q    AE L   L   
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2506

Query: 753  VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
             +L+        E++++   G       SL  + SA++ P +++      S  +   G G
Sbjct: 2507 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2558

Query: 813  DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
             A           +F  N    +I +    +S  YE L  L + + A L   ++ L    
Sbjct: 2559 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2611

Query: 868  SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
                 +  WL+K      + Q  P     E ++ + E   +F   L        E+    
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2671

Query: 923  EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
             +L +  P      + +Q   E+  +W +L  L  ++  +L  S    + L +    + Q
Sbjct: 2672 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2728

Query: 981  LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
            L+  L++ E     L P S +      Q  Q + L+ E      Q   +     G   S+
Sbjct: 2729 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2787

Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
            P  G+  +L+G++K+    V Q+      +   R  ++ ++       Q LL       +
Sbjct: 2788 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2845

Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
             L +K      VS    +  + L   Q + +EI   +++++   A  + ++AL   +   
Sbjct: 2846 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2905

Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
             E+   L  + +  ++++   E   Q LQ       + Q+  R+   +  T    Q   H
Sbjct: 2906 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2965

Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
              +   DV E  SL++ H++F + L+      E   A GE L+ ++Q      ++ QL +
Sbjct: 2966 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 3023

Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
            I+  W     + ++R  +L  SL+   ++K+ V  L  W+++     + +    +P+   
Sbjct: 3024 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 3083

Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
             +I +     ++ + E+      VE L      LLS     +E +    + L  K + + 
Sbjct: 3084 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3139

Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
             +          MT++  E Q+  ++ +  RQLQ AKEQL+  +     + + + L   Q
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3197

Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
              QK  Q L+ +   ++ LA  +   AS + G   S  +L+ ET  Q+H    + +    
Sbjct: 3198 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3255

Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
            +    +LQ              + +   + +   +P         A++L +K KE    +
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3306

Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
            KA   +++ +++S        + + A+              + + +QC +L       E 
Sbjct: 3307 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3366

Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
              E   + L++  +  +++ + + + E   E + P+    +    +    ++  K +   
Sbjct: 3367 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3426

Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
            LQ ++  + W   + L Q+A   T  +  E      + +  + + L +  A R  +L E 
Sbjct: 3427 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3482

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
             L    F    E L  W+   ++         + P  A     K  K Q Q +   QR+ 
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3534

Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
              R     +++R       +A P     + ++   L + W  L    + R   L      
Sbjct: 3535 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3594

Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
             +   + LE L +     EK       +      LE Q+  H+ LE +++   + L + +
Sbjct: 3595 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3654

Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
             + G+  K+    +   + Q +   +Q W + +Q +   R   L++A   A+ F     +
Sbjct: 3655 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3713

Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
              +W   V   L         + G  K  +  + L+ ++  R++   QA   G + L   
Sbjct: 3714 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773

Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
             G     +Q++L A++ +   + +      + L+   Q    L       C  L+    E
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833

Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
            +L+ +   LK      +    ++L ++ +    +L + ++  +AL E +    R  +   
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893

Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
            +    +R   V +    +   + A++L +  F QAA     WI    ++L   +  GD+R
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3950

Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
               D+    L+ Q  F  E+  H++++  + K G  ++ A S      + ++L  + K++
Sbjct: 3951 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 4010

Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
            + + Q  + R  +LE  ++ + +F +  +    W+ E +          +    L Q  E
Sbjct: 4011 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 4070

Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
               QLR  + E + +          I  ++    QL    P E   I ++    +  ++ 
Sbjct: 4071 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 4120

Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
               ++ +    L+ A+       + +D + + ++   E L Q      ++E ++  + ++
Sbjct: 4121 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180

Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
            + +  ++  +Q   E+L++    +  RS       +A  ++ +  ++   W  + +  ++
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4240

Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
            R  + LD +  A+K       L+V+ +  +  + D       P   ++  E  +  + E+
Sbjct: 4241 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4300

Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
            D   + + +  + G +L+ A G P    +++ +  L     SL  AW++   +L++A++ 
Sbjct: 4301 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4360

Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
             + +   ++ +  W+      LAS   +   L  ++  + + K  + +   Q  ++  L 
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420

Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
              A  L +    E+     +   M L+   ++L  +   R+H+LE  L  L  F     E
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480

Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
            + AWL     +  E+  +  D   +  +L K    Q ++ A     + + + G  L++  
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540

Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
             G  AS  +Q +LE L   W  + + ++++  +L  A  +A      +E+L+ WL   E 
Sbjct: 4541 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
             L A      LP    E L    E+ AA + K    ++L+ + Q  +      A+ ++++
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659

Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
                L ++++S+   L ER+T LE A +L ++F     + + W+ Q +  L  A      
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719

Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
            L  V    ++H+   +E++SH      +  TG  L    +F+  +    ++ L       
Sbjct: 4720 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4776

Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
             EK +  L     R R L    + A+QF     +   WL E    LDSE ++ +  +  +
Sbjct: 4777 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4833

Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
              L + +  ++ L A     +   +T   L+ + +   ++ K+   L  +R+    +  +
Sbjct: 4834 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893

Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
            +  R + L+E L       + L  L+D     +   AE Q    D++ V  L +   AF+
Sbjct: 4894 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4953

Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
            KE+     + V AL++ A  L  G+      ++ Q   +   WE +     ++   L AA
Sbjct: 4954 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 5012

Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
                      VH+  +  AE +  ++    L   ED      ++RTL  QH+   ++LE 
Sbjct: 5013 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 5066

Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
               E+ +  T    +  L    P  +  ++     ++A+ +E   W  Q     A   A 
Sbjct: 5067 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 5124

Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
            L   QEL       L WA+        E + +++   + L+ +H+   +E+
Sbjct: 5125 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175



 Score =  209 bits (531), Expect = 5e-53
 Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)

Query: 19  QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
           ++Q+KTFTKWIN      +    + +LY +L DG +L+ LLE++SG+ LP   +GR+R H
Sbjct: 213 KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 269

Query: 79  FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
            L+N   AL +L R +V +  I  ++I DG+  L LGLIW IIL FQIS I +  E    
Sbjct: 270 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 329

Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
           SA     KE LL+W Q+ T  Y  +   +F+  W DG  FNA+IH +RPDL+D  ++   
Sbjct: 330 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 384

Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
             L NL  AF VAE ++G+ +LLDPEDV  + PDE+S++TYVS  Y    ++ +G     
Sbjct: 385 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 441

Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
                 +   + E+   +Y+ +V  L++WI      +  R FP++   ++ L   +  F+
Sbjct: 442 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 495

Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
             E PP+  ++   + L   L+  ++    +     +G    ++ + W  L  A   R +
Sbjct: 496 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 552

Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
           AL+  + +L+ L+ +A R Q  + + E  L  A   L                      L
Sbjct: 553 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 596

Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
           E+G+     +FQ  AEIA  + +       +   RQ  + V  Q L+     Q  Q+  +
Sbjct: 597 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 641

Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
           Q V  L  E+ A  ++   +    R     Q    +  + Q  +   AQ + H +  S L
Sbjct: 642 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 700

Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
            Q  T  L SS  TS                                 VE    +   L 
Sbjct: 701 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 760

Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
           Q+++ L+     + +LL+Q L   E  ++  ++   W+ E   ++     G DL  +   
Sbjct: 761 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 815

Query: 643 LQKHKALEAEVHR 655
           L+ HK     VHR
Sbjct: 816 LENHK----NVHR 824



 Score =  203 bits (516), Expect = 3e-51
 Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)

Query: 872  ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
            + Q WL+ +     +  P   + D LE +   +++F   L     ++ +  +  E L  +
Sbjct: 2949 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 3008

Query: 929  YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
              G+    +Q Q   +   W       +E+  +L  S+E     +E   T        Q 
Sbjct: 3009 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 3068

Query: 980  QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
             L ++      L P   E++   L+  QK+         +L    + L SV    +E   
Sbjct: 3069 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 3125

Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
             E++ L  +V+            L+ + ++ +E  +V++ ++RQ +    Q  + +S   
Sbjct: 3126 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3185

Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
              ++      L++++ S+        L+   DL + +           AQ   + A D  
Sbjct: 3186 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3228

Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
             + +V   +  + Q+   L    +++  +L+  L+ +  F   +    +  A       L
Sbjct: 3229 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3286

Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
            D++    R+A +L +Q       L  L    EAL A  +            +   P    
Sbjct: 3287 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3342

Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
            ++  L+++  Q  +L  R++ R  Q+  +++ L+E+   + E   L+Q  EE     +  
Sbjct: 3343 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3400

Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
            P G         L   K  +  E E L  ++  + +  +G+ L+  + +    + ++  L
Sbjct: 3401 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3458

Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
              + ++W+ LN+K+ +R  +LQ+A           E LL  + D +E +  Q   + +  
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518

Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
                 ++  + LQ+     +S    +  +   +A+ A   A    IL++      R E L
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3577

Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
                  R  QL+     + + H+     N  L+ + + + +  P   T+     + +  +
Sbjct: 3578 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3635

Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
            HK L+ ++  H   + + +S G+SL      + + +V+   +    W  E++    +R++
Sbjct: 3636 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3695

Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
             LQQA+   + F  D  EL  W   V +K   +S +DY  +    + + LR++ +   L+
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3755

Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
            ++       + +E L QT    TG EV    ++   ++ R ++  +   ++A T ++ L+
Sbjct: 3756 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811

Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
               RLH      E+L  WL   +      E+     E A     +  + + + +     +
Sbjct: 3812 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3868

Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
             +   ++ +LLE            MV +  +  +     + +  +    A+  ++   + 
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928

Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
                L  +T+ ++K  SL  ++  +     AQL+  +    E++  +  + +L+++  ++
Sbjct: 3929 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3987

Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
               C   +  +++++   V + +  + +   +R  QLERA+ L+ +F     +   W   
Sbjct: 3988 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 4047

Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
             +  + Q+   + E  +   +   H+ LR         ++   K   Q  +L        
Sbjct: 4048 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 4107

Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
            Q+  +AA T   +++E+++                 D+ DQ+ ++  R  ERL   +Q  
Sbjct: 4108 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4164

Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
                E  ++ E+I   + VS+    L    E ++Q   + E  +      DK  +A   +
Sbjct: 4165 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4221

Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
             K  +   + + +  L++ R    + V ELAE +    H SL++          +D+I  
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4273

Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
              + L++P + P  ++ + +     +    E+   +E +  V   G  L+A    P    
Sbjct: 4274 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4328

Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
            V + +  L   W+ L +A   R  +LE+  +  +++   +     W+     K+ ++  +
Sbjct: 4329 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4388

Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
            G DLE   Q    L++F+  +    +    +   ++L L+ K  +  +   +     +L 
Sbjct: 4389 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4447

Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
              W S    ++  Q +LEGA L +      LD +   +   E L+ +    G D ++++ 
Sbjct: 4448 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507

Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
             L KH  L+ +V   Q+ VE++ +    L + S  E A  L+++ + + + W  +  + +
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567

Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
            +R++ LD AL QA+     +++L   L   +  R  + + P    P  A+  L  H E  
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4625

Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
            A  ++  ++       GQQ+L A  P S++  I Q +  L+++  S+E    E + +L++
Sbjct: 4626 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4684

Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
            AL L + F +S++    WL   E +L       P   ++ +L+   +HK+  +  EV + 
Sbjct: 4685 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4740

Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
            +   +E    G H     + Q  +       ++  R E + ++   R   L++ R + + 
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800

Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
            F +   ++  WL   EK+L +  E   D   +  QL + + FQ  L A         R G
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860

Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
            + L +    A +   + + L EL   W  +   S ++  KL++A   + +   +++ L +
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4920

Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
            WL  +E +L    P  G  +  V  L+   +  +  + K+    +AL   A+  +     
Sbjct: 4921 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4979

Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
             +  V+ Q + L  R++++      ++T LEA        R A+E  + V   L  LA A
Sbjct: 4980 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 5033

Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
            +              A+R L +QH+    ++    A        G  ++   H       
Sbjct: 5034 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093

Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
             H +     + E+ +A  +    R    L      Q+ L  LL    W        D E 
Sbjct: 5094 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5153

Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
            +    E  +AL+   +    ++    P ++++ +T
Sbjct: 5154 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5188



 Score =  150 bits (380), Expect = 2e-35
 Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)

Query: 253  QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
            +T+ +++ +   QLQE  L   +++  +  LL W+ + + +L A   P S        A 
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3516

Query: 313  FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
            F + + Q +  +L QR     L  R  T   ++ +  +     E     ++ +  + L+ 
Sbjct: 3517 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3572

Query: 371  AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
               A     + R  QL+ +  +A++F         +L   E+ L          + +E  
Sbjct: 3573 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3632

Query: 431  VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
            + +   LE  I+           I   L+        D+ + + + +  W   +Q     
Sbjct: 3633 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3692

Query: 491  RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
            R ++            +  + L+  +     +L +L     ST    +    + +LQ   
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3752

Query: 542  LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
            LL  Q      +V        E L  + G  V ++Q K   +    + +  L       L
Sbjct: 3753 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806

Query: 601  EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
            EQ LQ A  L +  EE   WL +    +         G + SQ   A  + K L+ E   
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3863

Query: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
            ++A+   L      L    P    +  E+  A     ++L+   +  +   +  A+L  Q
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3923

Query: 715  YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
             F  AA+A  SW+ E   +  SL      QDQ +A+          +V + F  E+ R +
Sbjct: 3924 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3974

Query: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
            +             +   L   G  +         +C      + K  L           
Sbjct: 3975 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 4003

Query: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
                  D + ++Y+++  +   R  +LE A +L   F  +  EL  WL E Q+++ Q   
Sbjct: 4004 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 4057

Query: 889  P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
            P  + +TL   Q ++      +A  K    +++ +  QL +  PG    IQ +       
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 4117

Query: 947  WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
            + Q++   +++AV L  ++ +   F  +       L  ++ +L      S+E      Q+
Sbjct: 4118 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4177

Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
            ++ K + ++  +  LQ +   +++ G               ++ +Q +++ +  + + + 
Sbjct: 4178 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4235

Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
              V +R  +  +  +  + F  +   L++  +  Q  +R  ++  +D +  ++     + 
Sbjct: 4236 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295

Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
            + EEI   QE L   ++  S+ +AA   PD   V  ++  L      L   W+ R   L+
Sbjct: 4296 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4355

Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
            E   +Q   +  DG  A       W+         +  +G D+      +++ ++F    
Sbjct: 4356 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4409

Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
                   E L    E L++  ++    HTV++ L  ++  W  L+ R   R+ +L  A L
Sbjct: 4410 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4469

Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
             L +++  + EL+ W+   +GL++  +P G     ++  L +H   ++++LA +  VEA+
Sbjct: 4470 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529

Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
             + G +L+     G+E  ++Q +L+ L  +W+ +  K  +R  +L  A +Q +    +++
Sbjct: 4530 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4588

Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
            D ++ L   E  L +S+    L  + + Q   H ++    E++  T  + M     M   
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4648

Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
               +A   I ++      + E ++  L  R  +L+ ++ L    H S  + ++W+ +   
Sbjct: 4649 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4708

Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
              +  S     L+       +HK    EV +H+ Q+  +  +G  L      Q   +++ 
Sbjct: 4709 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4768

Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
                ++  W ++ +    R + L  A    + F +  S+L  W+EE ++ L S  +   D
Sbjct: 4769 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4828

Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
                   + +H+  Q+ L    S  +  ++T ++L          +    +   LR++  
Sbjct: 4829 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4888

Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
             +   +  R  +LE  L    +F    + L  WL   +      + +  D +  ++L   
Sbjct: 4889 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4948

Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
               FQ ++   +  V A +  A  L+E        V+ + Q+L T W  +  L+ ++   
Sbjct: 4949 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 5008

Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
               ALR  E    V   LLE L +  E+       +  D   L   +  H+   ++L   
Sbjct: 5009 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 5067

Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
              +L +       V  +C       ++      + +     AWA    +  Q+R     A
Sbjct: 5068 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 5123

Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
             L+A+     A+  +  WA     D   E   QE       ++ HQ    E+  ++
Sbjct: 5124 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5179



 Score =  139 bits (349), Expect = 7e-32
 Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)

Query: 824  DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
            D   +   + + Q    +  + +  L      RL      F       EL+ +  KQ  L
Sbjct: 1722 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1781

Query: 884  LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
             + +Q  A  L  +    ENFL     G+ L  E  +  EQ       N  +I+ +Q  L
Sbjct: 1782 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1834

Query: 944  SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
                 + E L +     +    E  + +++   ++ ++ ++L  L  +   S        
Sbjct: 1835 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1889

Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
               + K ++ +   HF +     ++  + E  G      + GQV T Q  L Q  ++V  
Sbjct: 1890 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947

Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
            +     ++ QA    TQ+ Q  L++  Q L   E  + Q   KE+ V   +A   L E +
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 2004

Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
              ++  H  QE L++ DA           D  E  + L+   Q  QEL+ L         
Sbjct: 2005 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 2050

Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
            L   L+ QK       F+    +H+  L ++   G  V EA     + R+ G+ + T   
Sbjct: 2051 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 2102

Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
              E  R   H     +S +   + +   L+ +  ++   +  S      LLA LQ  E  
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2156

Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
               A   + + E     A +P    +N+ + L+  +A + ++ + +  VE L++    LL
Sbjct: 2157 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2206

Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
              R      + DIQ  L  +  ++E L++ + ER ++LQ       L R L  QD  +++
Sbjct: 2207 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2261

Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
                G ++SS  E GQ   +S  LQ    ++  LE +     + + A+            
Sbjct: 2262 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2321

Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
             S A  + A     S    E + KH   L  ++       L    S +L  F       L
Sbjct: 2322 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2381

Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
            + V   +P    T  ++ +  + S   +HK+           ++ + S  + +++ G P 
Sbjct: 2382 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2429

Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
             + +V E+   L   + E+E       EA   C +Q   FQ   + V  L+ W++E    
Sbjct: 2430 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2486

Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
                +P   + D G+    T +L  K      E+    +S   L      +T P      
Sbjct: 2487 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2546

Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
                                        + +    +     +    L++  A  + +L  
Sbjct: 2547 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2605

Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
              +L +   E+  +  WL    + A   +      D E       +   F+ +++    +
Sbjct: 2606 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2663

Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
            V   +     LLE        P  +Q   ++ + W EL +LT  R   L ++   L   +
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2723

Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
             +   L Q    +E   S+   ++ D   L  Q +  Q L +E   T +   E L  AG+
Sbjct: 2724 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2782

Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
                 PG        V+++  AVTQ W  L  ++  R   +++A + + ++++ +R  + 
Sbjct: 2783 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2842

Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
              + +   L    + S  P +   +L   Q ++ E++  +K  + A  L +   AL+   
Sbjct: 2843 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2902

Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
                E+  +L  +      V Q      + LQ+        ++  R  +  +   +E   
Sbjct: 2903 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2962

Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
            K+  + + ++ +E LI+ H+ F K LTAQ    E  + E    L + +  ++  + LQ  
Sbjct: 2963 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 3022

Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
                       +VKE       +L  +L    + +       WI      L+E     D 
Sbjct: 3023 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 3079

Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
             +    + K ++ + E+  H  ++  +     +LL+        V+   + L +  + + 
Sbjct: 3080 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3139

Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
            + +  +   LE+  + F EF +    ++  +Q  + ++++ D LG               
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199

Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
                Q L+H + L +RL +     A D+ G       SD+ LQ        V+ I Q  S
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3245

Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
             L+             QQ  E    +    + + +    I  +E   Q  +   +L+S+ 
Sbjct: 3246 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3290

Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
             + R  E L+++   I+A ++ LE          + C       + SP+   G++   + 
Sbjct: 3291 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3349

Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
            +++   +L  RAQ R E ++  + + ++  + L+E  +  Q+     ++        E  
Sbjct: 3350 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3409

Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
                 M +  Q  K E++            GQ L+ +    +S       GLE +L  + 
Sbjct: 3410 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3462

Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
              W+       +   QLQ+A L    F  ++E +  W+   E+ +A++    P A  + +
Sbjct: 3463 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3520

Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
               + + K+L+  L+ +   +  ++     +     P +    L +   +  R EAL  +
Sbjct: 3521 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3580

Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
            A TR  +LE +  + Q F +  + +  WL   EK LV  E      + L  Q+ + +  +
Sbjct: 3581 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3640

Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
             + ++ + H  Q +       +       + +Q +L+     + E+Q+ S  +   LQ+A
Sbjct: 3641 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3700

Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
             C A        EL NWL  +  +L   +V   +  G+ +     R L+  +  + +  +
Sbjct: 3701 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3760

Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
                  QA +     L Q   ++              +Q++  A++AR      ++D   
Sbjct: 3761 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3795

Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
                   KL    A+   Q+L   R L   H+ L       E E+ S+E  T+V+ G   
Sbjct: 3796 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3844

Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
                       E A++ Q   K    L+ EA   + LL    E    L EL+    W A 
Sbjct: 3845 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3887

Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
             G   + +ED       +  + +++E    +++A   R ++  Q A              
Sbjct: 3888 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3930

Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
             A+L  + E   +L+   + R    Q   QL   +  T+ +             +D   D
Sbjct: 3931 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3979

Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
            L  VK   +   A  +E +   + K+  + K   T+ +    RY  ++  +S +   WE 
Sbjct: 3980 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 4037

Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
             ++     TE           Q   ++L     E               ++R  Q++HR+
Sbjct: 4038 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 4074

Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
            L   +   +  + ++     +L +L P     + +   A  TL ++ +E          +
Sbjct: 4075 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 4134

Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
             ++Q+ Q H  + +  E L    ER  L     ++ +V   ++ + +++ +  ++ + + 
Sbjct: 4135 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4192

Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
              + L+Q G++++  S     +++   + ++ +L ++   W
Sbjct: 4193 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4231



 Score =  136 bits (342), Expect = 4e-31
 Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)

Query: 469  VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
            VA RQ+E   + Q +   L Q + + +   +A +     VE   +Q   EELQ+  + +A
Sbjct: 1730 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1789

Query: 526  CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
              Q LAEVV           E L + D       L EA++     ++    Q   ELD  
Sbjct: 1790 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1846

Query: 568  LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
            + T+++    K   + QL++S   +                     + ++EQ     Q  
Sbjct: 1847 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1906

Query: 608  EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
            +      EE+       +   +  +G     +    QK KA  E  + +HQAV +     
Sbjct: 1907 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1966

Query: 667  GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
               L  +     P+  E+ +      ++     +    +       LQ     + AD  E
Sbjct: 1967 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 2026

Query: 722  AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
               WL++    LE    G D      T L+R       + +   +LR +   G      A
Sbjct: 2027 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 2086

Query: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
                                     SC    G         + D       + +  DH +
Sbjct: 2087 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 2114

Query: 841  QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
              + SL +   +    L++ +  +     +SCG                          L
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2174

Query: 874  QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
            Q  LE+   L  ++  Q   +E ++   E  L A         ++  + + +  RY   S
Sbjct: 2175 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2234

Query: 934  TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
              +  + E+L               + L  S+ V   L E       +   L +   +  
Sbjct: 2235 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280

Query: 994  GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
             S+     ALQ    K ++LE+ +   QS +  + E      +        +LQ  +K +
Sbjct: 2281 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2335

Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
              + ++ + +  ET A+   L+   +L    +E +Q  L +K     EV V       L 
Sbjct: 2336 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2395

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
            +  Q+   E    ++ L+ L +  + ++      S  +P+   ++ ++   L   +++ +
Sbjct: 2396 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2449

Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
              ++E  E +     ++D F     + ++W+                ++LG+ + +   L
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2509

Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
                      +Q+    G     L+S +   A+A+ A   G  ++  +  A +T      
Sbjct: 2510 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2569

Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
            + L SI+   T +    E     L   +A L     +LQ+ +++ + +MQW+++    A 
Sbjct: 2570 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2629

Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
                 P+      ++T ++++++ E+EL      V+ L+    ELL   P   E  + + 
Sbjct: 2630 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2689

Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
             L  + SKW+ LN+   +R  +L+++      L Q Q  + QL+Q  +E  L  S  G  
Sbjct: 2690 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2746

Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
                  L  + QQ++    E  T   +   L +   G+ + P         + E+     
Sbjct: 2747 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2806

Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
            ++ + L G L+ R   + QA V+  Q+  L        S+++    +       P +  +
Sbjct: 2807 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2866

Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
             L  AQ + ++ ++ + ++K  Q   + +  L     L A    Q + I++      Q+ 
Sbjct: 2867 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2926

Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
            E H   L+ AC +  Q  Q +  FQ + LD  + E      +  K  ++ S     +D+ 
Sbjct: 2927 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2985

Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
            +   A   +  K  A  E L +     E+     Q  T          +V E++  ++E 
Sbjct: 2986 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 3045

Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
            L + L+                  L+E+    D  E E ++ +L    +E +   G +  
Sbjct: 3046 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 3105

Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
                A    S+ E D E                    H+   C      KF +FQ +V  
Sbjct: 3106 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3164

Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
             S+R   C   A+  L+   S G          M++ +Q+ LQ            A   +
Sbjct: 3165 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3221

Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
             E + ++G    L   ET  + H  L +   QV EK + L           N  R++   
Sbjct: 3222 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3278

Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
                + +L S   + R+    ++Q          L+ L+ +     K C          P
Sbjct: 3279 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3338

Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
                +++  +A+++    L  R + R  Q+E   + L  F + +++++     + Q  + 
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3394

Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
             E SQ P     +    Q      + + E+E  +   Q    LGQ  + +A   T     
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3449

Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
              + L+   D V   W    +++ Q   Q Q  L  CGR ++ L +        +E+   
Sbjct: 3450 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3509

Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
                 +  + V+  I++ ++  ++L  +      ++   E++ T   P    ++  +L +
Sbjct: 3510 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3569

Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
            L  R   +   AE+R   L   S++   F +      +W+    ++L    P G    KL
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3629

Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
             + + +H+A E ++  H + +      G++L   S     ++ Q      + W       
Sbjct: 3630 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3689

Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
                 E L+QA+       ED    + +L  V        +K  K++V D   +     Q
Sbjct: 3690 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3742

Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
               R+ +         V  A +  +      LK    +EV II  +   +  R+      
Sbjct: 3743 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3798

Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
                 + LE AL+    +H    EL     ++ E E L       K  E+ Q  +R  +E
Sbjct: 3799 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3856

Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
            L++E    +A ++SL      L +  P  A  GL     E  E +  +     ++ E +D
Sbjct: 3857 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916

Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
            A  L   Q  QA   EL    +  +  M          +    L+  +    E+    D 
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976

Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
            I     +G +++TA        +++ L  + +   ++     E  LQL++A  L   F  
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036

Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
            + E++  WL   +  ++   L  P    E L     +H+ L   +      I  +  T  
Sbjct: 4037 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 4094

Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
             L +    E  S   +  A       +      R   L+E          ++   L+  +
Sbjct: 4095 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4154

Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
             +   LR+   ++ E        +  Q+ + +N   +++      + L++ G+ ++   G
Sbjct: 4155 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4209

Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
            G     +++A+Q++L+++  +W  +    +++ AKL           C+ + L  ++++ 
Sbjct: 4210 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4269

Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
            ++++  +E     P+V +      E +     G Q EL+  ++    +  A  G+    +
Sbjct: 4270 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4328

Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
                     V++    L   + SL +  ++R   L EA    +++         WV    
Sbjct: 4329 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4379

Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
              LA+    G  L  V+   E+          Q +E E  +H+A  L + V     K   
Sbjct: 4380 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4436

Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
                  H V   + +L+     L      R+  L+ A  A  QF   L E  +WL    G
Sbjct: 4437 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4490

Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
             + + + +G   +A +  L +    + D+ A    +E + +    L+ES    E+  +  
Sbjct: 4491 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4550

Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
            +L+ + +    +L + E R              HG  E LQ    + E  LL +      
Sbjct: 4551 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4610

Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
                 +     +E     E K + ++  +Q  GQ  +    K A T          +I  
Sbjct: 4611 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4659

Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
              + ++  WE ++  +  R     E L  A E H+  Q    +    Q +  L       
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4717

Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
              L +V     +H+    E+ +  +++  L      L          L K     VQ  W
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777

Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
              +  +  ERG+ L  A  +   F     +L+ W +E ++   SE E+A D    +  L 
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837

Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
            QH+E  + +           + G+ L + +      +     +L+  L EL + W
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4887



 Score =  132 bits (331), Expect = 8e-30
 Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)

Query: 306  MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
            + Q L  F +F+ +E  P   ++     L   L  +         L H+   L +++  W
Sbjct: 3409 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3465

Query: 366  AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
              L    A R+  LQ+ LL          RFQ       S++ D E+++   + P A   
Sbjct: 3466 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518

Query: 426  TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
             V+A +Q   +L+           ++ +EG +    AE AD ++         + ++   
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3569

Query: 476  VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
            +  RW+ LL   + + +Q+  +  V     E +E  +  L  +++  R   C   G Q +
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3627

Query: 532  EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
            ++ E + +H  LE  +  H  H+            S+G S++VL +   K    ++L  S
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3679

Query: 589  LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
             V  +       +R  LL+Q L  A+     E E   WL E   ++   ++    ++   
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3739

Query: 642  ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
              Q   + L+ ++   +      +  G +L       +   G+    +Q   + ++    
Sbjct: 3740 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3789

Query: 701  GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
               AR +    +    A   E A  L  R  S     C         LL    ++ +   
Sbjct: 3790 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3846

Query: 761  AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
            A  A++R  E +  A + +A L ++N   S   E +                  W+    
Sbjct: 3847 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3889

Query: 821  AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
             E     D        D ++Q  E + A A LR  + ++A        +  EL  W+   
Sbjct: 3890 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3939

Query: 878  EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
            EK+ + L  ++ + D         + F   +   K +  ++  S  ++         Q +
Sbjct: 3940 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3999

Query: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
            +++ +++ + +  +  +  E+ +QL  +  + +      +E  P   + + ++ QL A  
Sbjct: 4000 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 4057

Query: 993  PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
            P    +T    Q    Q + L+ E + H   +     ++ E    E   +Q +      L
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 4117

Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
              Q++E V +RA    E  ++ + F  +  Q+L   E +  +LR    +S +V   +  +
Sbjct: 4118 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4177

Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
             E++++  ++   Q   + L  + + M A      +++  + + +  +  ++  +WE   
Sbjct: 4178 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4235

Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
                +R+  L + +EL +KF  +      T  + Q ++  L++ G             E 
Sbjct: 4236 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295

Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
            +RE +  LQ+  +   ++  LG  +E + A GE       P    V++ +  + + W  L
Sbjct: 4296 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4343

Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
                + R  +L  ++Q     QD +  +  W++   G +A+  P G     + Q ++  +
Sbjct: 4344 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4403

Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
              +SE    +  +E L     ELL ++   + D   +Q  L  L+  W++L  ++  R  
Sbjct: 4404 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4462

Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
            +L+ A    GQ +  L +L      L   EG L   +  G D ++ +    +H  L+++ 
Sbjct: 4463 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519

Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
                + + A+    + +  S A  EE      +LE+L             R  QL  ++ 
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578

Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
              +  H    +L  W+ +   H        G P +  E LN        H E+    +A 
Sbjct: 4579 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4631

Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
            +   + ++  G+ + A     A+  ++Q    L+  W  +E     R   L++A+     
Sbjct: 4632 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691

Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
            F + + +   W+ +      V+SR     +    + I++H+    E+  +   + ELD+T
Sbjct: 4692 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4750

Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
               L      ++Q VV         Q R  + ++ L E   + D   +   + HE   + 
Sbjct: 4751 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4807

Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
              L  WL   +++      +  DP+       +  +FQ  +               SL E
Sbjct: 4808 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4865

Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
            +   A   ++      +L+  W  +   +  R + L +         D L+ L       
Sbjct: 4866 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4925

Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
            E   +    V  D+  +   + +H+  ++EL      +Q L  +A   ++L  G +  + 
Sbjct: 4926 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4982

Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
             V+ + Q ++  W  +      ++ +LE A R    F + V     W A   Q L+    
Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 5042

Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
              +       L   H+    +LE +     +AT +G   L      +    +    +   
Sbjct: 5043 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
            R +    WA++ ++  A     L  ++   LE +LA  + +  T        +   +EEV
Sbjct: 5103 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5161

Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
            + LI +H+ F++ +T   +K+  + +  KT +R R  D  P  LQ  + V +   +    
Sbjct: 5162 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5215

Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
              AS L  S +Q   + ++         W Q W   L+      D  D+L+ L +   F+
Sbjct: 5216 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5275

Query: 2161 AEV 2163
             ++
Sbjct: 5276 FDI 5278



 Score =  110 bits (275), Expect = 3e-23
 Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)

Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
            ++  L Q +T ++  +  V +L  WV+E +  +   ++G D  +    +  H+ +   + 
Sbjct: 768  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 827

Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
             + SS++E   +   +T P ++   +++   RL  Q   L   +  ++R L+    LH F
Sbjct: 828  EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 882

Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
            +  A +   WL ++K+  +      E   +        A+   +++   + + + + +AE
Sbjct: 883  VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 941

Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
             LL   H A   +   +  +QT WS + +L Q     +++         D  E    ++ 
Sbjct: 942  QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 1001

Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
               ++    +   C   + +   + L +E   +  + +ELL+    +  L          
Sbjct: 1002 LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 1045

Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
                 + +A  ++Q +       L+ +  +     A+ DY           Q+E +  + 
Sbjct: 1046 -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 1086

Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
                L  ++H   RA+       W+  +  G +A++         P KE  +    ++ Q
Sbjct: 1087 DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 1136

Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
               V   W      +++       + E   ++ I A+   S+KT   G   + +  L  +
Sbjct: 1137 YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1193

Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
             E FL     +D +E+ +       +  +  +      Q  ++  E  E        +L 
Sbjct: 1194 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1246

Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
            ++       + E+      +Q++ P+   DL + +  + + +  + E++  ++ + ++  
Sbjct: 1247 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1306

Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
            K E   +Q+   +   + R + L    +++ Q  ++    ++  +     L+    AEA 
Sbjct: 1307 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1365

Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
            ++  E K+           N+ +L   L+   Q R  + E R   ++  D +  A  ++I
Sbjct: 1366 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1420

Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
            SD   +       +     ++  QL  RW + H        Q++  L             
Sbjct: 1421 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1460

Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
                            +DLE + + L+ + +     HP+   ++ +E    ++ +  PE 
Sbjct: 1461 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1501

Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
            +  L  +  QQ++  S  +++       QK  E   A  +  +LQ M    +V +Q+   
Sbjct: 1502 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1558

Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
                    +SPV+ RRM         E +D  T   +L     Q +  AG          
Sbjct: 1559 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1602

Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
            L  LE+E  SLE   +EH   +++A ELQ ++S++ K              ++ + S+E 
Sbjct: 1603 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1659

Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
            S   E L + L  ++  L KH  KM + +      ++  L+ +   L      + Q +  
Sbjct: 1660 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1719

Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
                 +  K    RQ    +   E+L+ +   L  +        E  L+  +E  +    
Sbjct: 1720 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1767

Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
            T  L     KQ+  Q ++  S     E+ +  +  L + G   S+     I+++L E   
Sbjct: 1768 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1827

Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
               +L    + S+K++ K+         +K     +L  S  ++EN   WL  ++ +  R
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1887

Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
            A T                     +G+     G LL          TQ  L     K   
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947

Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
            Q E ++ Q QA +           ++G  L+ + +E+ ++ ++  K     +L E  ++ 
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007

Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
            +     +  L KF  D  E   W+Q+ +  L   +     ++ +    ++ ++   ++ S
Sbjct: 2008 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 2067

Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
            H+   R +  +G ++++A    +     +V          ++L+ A    R+  ++  +L
Sbjct: 2068 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 2127

Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
                ++         +A   L       ++    H +E      + L R+LE TK     
Sbjct: 2128 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2187

Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
            + +    +E+L++TA  LL++R +  P    +   L  +   + +L +    R   LQ  
Sbjct: 2188 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2247

Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
            L      ++ L  +LD W+    ++ + Q          QD+    ++ E+  A R    
Sbjct: 2248 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2302

Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
               Q+ + A+  K+   +E   P     +QA+   + A   R  +A     E LA   E 
Sbjct: 2303 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2356

Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
               V  F+  + +LQ  ++ KT AL + +  G  ++ +    Q       +H++    L 
Sbjct: 2357 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2416

Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
            ++ KE++                P   A V E    L  K +E    + +  +       
Sbjct: 2417 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2464

Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
               AF    + L +W    +E      + +   GAE L    E+  +   +  L+  +++
Sbjct: 2465 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2521

Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
            +     +   + +SA  T             +   EG     EE WA +        GL 
Sbjct: 2522 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2573

Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
             +++ +                 D  H   D+ LLL       +  L KL  AQEE  A 
Sbjct: 2574 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617

Query: 3444 MQ 3445
            MQ
Sbjct: 2618 MQ 2619



 Score =  108 bits (270), Expect = 1e-22
 Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)

Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
            +VAS + +L  EHQ +L  +   Q R +     SQ        D  ++   + V  Q  Q
Sbjct: 1171 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1227

Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
            EL    E+ +Q   E      +  EV        N +          L  D+L E V   
Sbjct: 1228 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1284

Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
                +  +E  RL   LG           +   S   +  T+R +L  +     ++   S
Sbjct: 1285 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1342

Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
                 +L  ++ L       AE +  + E  L         + NI   +   +   SE+ 
Sbjct: 1343 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1401

Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
              R+   AL+    EL   +    E  +T             +   L  +W+ ++ ++  
Sbjct: 1402 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1458

Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
            R  +L+  G+  +  R     L D  +Q+E  +  +Q ++       + +L ++ + L S
Sbjct: 1459 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1517

Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
            E     +KM      A   +A+    E      R +   Q    ++  ++Q+S +L   +
Sbjct: 1518 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1577

Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
            F  L     + V         T Y +    + + L  + K L+ E K H       Q  V
Sbjct: 1578 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1631

Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
              +  + +    +G P         +E+     +L  A +          T Q +     
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1676

Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
                       L    D   DE     L  + + LQE   + +S  E L Q  ++ T  +
Sbjct: 1677 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1722

Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
            V  ++++V ER +E    LQ     L  T +R +         +GT+ L ++  + E+LQ
Sbjct: 1723 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782

Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
              +    QA             + GE L ++ +  +      AK + +            
Sbjct: 1783 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1842

Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
                    ++  +++VAA + L ES  +  +     +    +D + A ++  ++ +  G 
Sbjct: 1843 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1901

Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
              ++ +          V+ +LLE  T V  +  +   N+ +    ++AQ        + +
Sbjct: 1902 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1959

Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
            +   +  Q LLE  G  Q L P  +    +  ++        L    ++ +        L
Sbjct: 1960 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 2017

Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
             +F     ++  W  +  Q+L+  E+  +  +G + KL   +    ++ + +   +  T 
Sbjct: 2018 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 2077

Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
             G + L AA + +K             EVQ +L    D+   +Y         L+   ++
Sbjct: 2078 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 2137

Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
             +      CG L  + A +  + K  +   +V+  + L R+ E   K L  Q   +    
Sbjct: 2138 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2195

Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
            E+LK      +  R  +L     +Q+ +     R ++L++S   R   L  +L  + S  
Sbjct: 2196 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2255

Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
                +  DW+      LKE    P+    L+D +    K+   E ++   +  + ++ +K
Sbjct: 2256 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2312

Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
             +  +  + P  A  +  +++ L   + +          ++E+ +  +E  + + +  + 
Sbjct: 2313 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2372

Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
            +++ K   +   D+ G+D+    Q ++    EF  +     V  + ++ IS   L     
Sbjct: 2373 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2427

Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
             P +  ++ ++ + L+ ++      +   ++ +    E      VL + L +  K   +K
Sbjct: 2428 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2486

Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
              ++Q    A D GK LE  ++L  K      E+  +     SL   +  +   +   A 
Sbjct: 2487 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2546

Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
                G     +  A   E +W                         L+ +  +    L  
Sbjct: 2547 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2606

Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
            L +AQ+  + + + L    +   +   +PAP      +  +E+++  +AEL    + +  
Sbjct: 2607 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2666

Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
             +    +LL          R      +Q L+ ++  WQE +QL +  QQ LE     L  
Sbjct: 2667 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2721

Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
            F +   ++++WL  KE  ++  G   PL+    +L     + ++L  +   +  +   L 
Sbjct: 2722 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2778

Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
            A  +G+    G  P  +  +    A + +K ++L  Q   R   +++      Q Q+ L+
Sbjct: 2779 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2838

Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
               +  + L  K   +L       AM   QL+  Q  + E+     Q    Q L  +   
Sbjct: 2839 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2897

Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
            L++  +  +E +  +LE +   + +++  ++  V  LQ AC  + + ++   + + WL+ 
Sbjct: 2898 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2956

Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
              E + ++  +   L  +  L+   ++    +  ++   E  + + +   ++        
Sbjct: 2957 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 3016

Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
            ++ Q   +   + +  + ++ER   L E+    LK+    +    W+   Q  L  +   
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076

Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
             D  +  +++  L    ++L+ EM  H  +  ++  T   L+         V    + L 
Sbjct: 3077 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 3132

Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
            + +  +  +   ++  L+   Q+ ++F     E+   L      LD  D   S   +   
Sbjct: 3133 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3192

Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
            L  L+  ++ L+A   +++  ++ A   ++E+  +  +  VL Q++ + + H+ L ++ +
Sbjct: 3193 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3252

Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
             +   L+ +LQ        + ++  +    D  L + A        G+D E ++  +E  
Sbjct: 3253 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3306

Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
             AF K++++L  +   A +     L        P +   +  +EA  +   Q  K     
Sbjct: 3307 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3361

Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
             A   +V    +   E   +++E + L+ K E+   S   V     T+ QQ        +
Sbjct: 3362 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3421

Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
             E+E ++ +    Q +   LGQ  +  AA           L  V   W TL  K  +R  
Sbjct: 3422 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3477

Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
             L +A      F    + LL+W  + +EL ++++         +   Q ++L Q + + R
Sbjct: 3478 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3537

Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
                + +++EG+++   +      ++ + L  L+ R +  L +A     Q    S   Q+
Sbjct: 3538 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3597

Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
              + LE    WL   E  L+  +  G   S +E  + +H+ LE                 
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3657

Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
               K+L+++E+K     K +  Q   ++ QE    R+
Sbjct: 3658 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)

Query: 246  CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
            CS   + Q+++++L K+L              LQL+  + L  Q+ +   +L  W+ E Q
Sbjct: 3991 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 4049

Query: 292  MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
              +        LPA    L   T+ + QE+  +L++      L+   +  +   N+    
Sbjct: 4050 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 4095

Query: 349  --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
                 P EG  + E    +   +   +   + +++R + L    + + +F  K    +  
Sbjct: 4096 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4149

Query: 407  LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
            L+  E+++++ R PP+  A VE   +++   +   +  E + Q L E      +E     
Sbjct: 4150 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4208

Query: 465  -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
                   S   V  + +++   W+ +   ++ +  ++ D+  +        +SL+  ++ 
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4268

Query: 510  ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
                + +L++P    +  +Q  E  E ++   D L+ ++       S L     E D   
Sbjct: 4269 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4327

Query: 569  GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
                 +++     L     SL    + R   LE+ +Q A ++    +    W+   G ++
Sbjct: 4328 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4382

Query: 628  GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
             + + +G DL  +   +++ K  ++E ++ Q + ++ +    +L  ++   + D     +
Sbjct: 4383 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4441

Query: 687  AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
             +      W  L+ R++ R  +L+ ALL L  F  A  E  +WL      L E+   G D
Sbjct: 4442 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4501

Query: 742  QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
              A E  L +H  L+  + A  + +                     A++  G  L     
Sbjct: 4502 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4541

Query: 802  WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
              EAS                         +    + L+Q ++++    + R+ +L+ A+
Sbjct: 4542 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577

Query: 862  -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
                GF     +LQ WL   E+  +  + +    +T +     +     A    +  +  
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4637

Query: 918  VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
            +    +Q+  R P ++ T I +    L ++W  +E    E+  +L    E  +   E   
Sbjct: 4638 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4694

Query: 977  TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
            +     + L Q E     A +P    DT    Q+ + K    E   H  +  ++++++ G
Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4751

Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
                 +++ Q    ++  + ++Q   ++V +++ +R R   + + R + F +   +L+ W
Sbjct: 4752 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4811

Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
             E  +  L S+ E++ D    +  L +H++  + +   H   +   +     +   +L  
Sbjct: 4812 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4870

Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
             D+ ++ + L  L  +   +     +RQ  L+E L     G+  D   A       WL+ 
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4924

Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
                L E      D+   ++L+  H+ F + L       +AL+    +L++     +  V
Sbjct: 4925 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4984

Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
            + Q+Q +  +W  +   S  ++ +L A+L Q +E+   V  L++W+ E +  +  H    
Sbjct: 4985 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 5044

Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
               + L+TL  +H+    +L   R  +     +G  +L+   C  + I T        W 
Sbjct: 5045 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 5097

Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
             + R   E  + L  A Q +Q L      L   +E LE L   LQ +ET    +  + + 
Sbjct: 5098 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5155

Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
               Q++E     +A     +  M       P + + T+ + RR      LQ H+ +
Sbjct: 5156 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5205



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)

Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
            Q   ++E  ++ +QD    +++++  L  +E G DL S +   + H+ +     E ES  
Sbjct: 774  QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 833

Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
              AK++ +   A      P  L   +K L RLE     L       +  ++ LH F   +
Sbjct: 834  KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 886

Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
              EL W+ E         ++E           H EL  E+   +  ++ V      L   
Sbjct: 887  TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 946

Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
             HP    I      ++  W+ + + C+   Q +++   + ++F D  E   ++   +  +
Sbjct: 947  NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 1006

Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
              R Y  D ++++     L+ +    +EEL  Y S++  L   A+T+
Sbjct: 1007 -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 1052



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)

Query: 209  VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
            V E +  + +LL+        P  + ++T +   +   ++L    T+ R+      +L+E
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2714

Query: 269  TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
            +    TQ++ + A L +W+ EK++ +         P+ L   RQ +          KP  
Sbjct: 2715 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2774

Query: 325  LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
             Q   A + +L R     +  + R  +  +   LA ++Q W  L    + R   + Q ++
Sbjct: 2775 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2828

Query: 385  QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
            +  + ++L R    K +  ++ L  +  V     A    L T +   Q +   +  I   
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888

Query: 445  EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
                QAL E    L +E+Y   A+++R+ E +   ++ + Q  +            +  L
Sbjct: 2889 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2933

Query: 505  QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
            Q   A+SHQ +++            +E  +S     +L  +  L++ H      ++A   
Sbjct: 2934 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2991

Query: 553  HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
              SH+ ++T     +L     G+    LQ +  T+     +    V+ R   L+++L++A
Sbjct: 2992 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 3049

Query: 608  -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
             ++    E    W+ +C   +       D ++   ++ K K+L+ E+ +H
Sbjct: 3050 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 3099



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)

Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
            +L   + E    +   + G  L SV +  + H+ + R +E  E  +     +  ++ ++ 
Sbjct: 788  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 842

Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
              AP  L       +++  +A L   ++ + + L      H F+ R    L W  E++E 
Sbjct: 843  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 899

Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
              + + +E      +    H EL +E+ +     + +++  +QL+  +H   A +T    
Sbjct: 900  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 953

Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
             +E     ++  W+   Q C      Q + Q +++  A+   +       DY  ++ D  
Sbjct: 954  -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 1005

Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
              + R    ++  ++   K   + +  ME+ E LLQ +       G + T  Q +P
Sbjct: 1006 --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 1057



 Score = 40.0 bits (92), Expect = 0.042
 Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)

Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
            Q LL W + +Q QL   E   D+ S +  L  H+++   I  ++  L++       M A 
Sbjct: 787  QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 845

Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
              P        L  L  + Q  K+L   R Q        ++    +  F +   N   WL
Sbjct: 846  --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 893

Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
            +    + +  D  E  + + +    H E  R L       ++++   E+L+   HPA  T
Sbjct: 894  NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 953

Query: 1250 VREQLQSIQAQWT 1262
            +     ++Q QW+
Sbjct: 954  IEAYRAAMQTQWS 966


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 132,236,185
Number of Sequences: 37866
Number of extensions: 5922558
Number of successful extensions: 44898
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 835
Number of HSP's that attempted gapping in prelim test: 25575
Number of HSP's gapped (non-prelim): 10060
length of query: 3639
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3517
effective length of database: 13,627,866
effective search space: 47929204722
effective search space used: 47929204722
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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