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Search of human proteins with 170016061
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
(3639 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 7109 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 936 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 930 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 929 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 879 0.0
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 872 0.0
gi|67782319 spectrin beta isoform b [Homo sapiens] 869 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 643 0.0
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 637 0.0
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 567 e-161
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 358 4e-98
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 357 9e-98
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 357 9e-98
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 357 9e-98
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 357 9e-98
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 357 9e-98
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 357 9e-98
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 357 9e-98
gi|4501893 actinin, alpha 2 [Homo sapiens] 346 3e-94
gi|33188445 microfilament and actin filament cross-linker protei... 345 5e-94
gi|4557241 actinin, alpha 3 [Homo sapiens] 345 5e-94
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 344 1e-93
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 344 1e-93
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 344 1e-93
gi|12025678 actinin, alpha 4 [Homo sapiens] 338 7e-92
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 269 4e-71
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 254 1e-66
gi|221316624 dystonin isoform 4 [Homo sapiens] 222 5e-57
gi|221316622 dystonin isoform 3 [Homo sapiens] 222 5e-57
gi|221316618 dystonin isoform 2 [Homo sapiens] 222 5e-57
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 7109 bits (18445), Expect = 0.0
Identities = 3639/3639 (100%), Positives = 3639/3639 (100%)
Query: 1 MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE 60
MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE
Sbjct: 1 MDSQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLE 60
Query: 61 LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII 120
LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII
Sbjct: 61 LISGEALPPPSRGRLRVHFLENSSRALAFLRAKVPVPLIGPENIVDGDQTLILGLIWVII 120
Query: 121 LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL 180
LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL
Sbjct: 121 LRFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNAL 180
Query: 181 IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS 240
IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS
Sbjct: 181 IHAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVS 240
Query: 241 LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP 300
LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP
Sbjct: 241 LYYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFP 300
Query: 301 DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE 360
DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE
Sbjct: 301 DSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAE 360
Query: 361 LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP 420
LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP
Sbjct: 361 LSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAP 420
Query: 421 PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480
PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW
Sbjct: 421 PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480
Query: 481 QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540
QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH
Sbjct: 481 QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540
Query: 541 DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL
Sbjct: 541 DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
Query: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC
Sbjct: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
Query: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA
Sbjct: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
Query: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA
Sbjct: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS
Sbjct: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
Query: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK 900
QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK
Sbjct: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLK 900
Query: 901 YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960
YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ
Sbjct: 901 YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960
Query: 961 LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL 1020
LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL
Sbjct: 961 LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFL 1020
Query: 1021 QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL 1080
QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL
Sbjct: 1021 QSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLL 1080
Query: 1081 LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140
LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD
Sbjct: 1081 LWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN 1200
SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN
Sbjct: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDN 1200
Query: 1201 LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ 1260
LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ
Sbjct: 1201 LGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQ 1260
Query: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH 1320
WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH
Sbjct: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH 1320
Query: 1321 EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL 1380
EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL
Sbjct: 1321 EAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDEL 1380
Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM 1440
QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM
Sbjct: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKM 1440
Query: 1441 AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW
Sbjct: 1441 AALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
Query: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ
Sbjct: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
Query: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG 1620
HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG
Sbjct: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYG 1620
Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680
RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL
Sbjct: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680
Query: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK
Sbjct: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
Query: 1741 FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD 1800
FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD
Sbjct: 1741 FQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRD 1800
Query: 1801 TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL
Sbjct: 1801 TETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
Query: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY
Sbjct: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
Query: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT
Sbjct: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
Query: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
Query: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
Query: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE
Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
Query: 2161 AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR
Sbjct: 2161 AEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR
Sbjct: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN
Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP
Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT 2460
EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT
Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDT 2460
Query: 2461 SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE
Sbjct: 2461 SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL
Sbjct: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR
Sbjct: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH 2700
HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH
Sbjct: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMH 2700
Query: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760
QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS
Sbjct: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760
Query: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR
Sbjct: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
Query: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL
Sbjct: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ
Sbjct: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ
Sbjct: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ
Sbjct: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH
Sbjct: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA
Sbjct: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE
Sbjct: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
Query: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV
Sbjct: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
Query: 3421 ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ 3480
ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ
Sbjct: 3421 ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQ 3480
Query: 3481 GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD 3540
GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD
Sbjct: 3481 GLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLD 3540
Query: 3541 ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA 3600
ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA
Sbjct: 3541 ERMAAEKVASIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRA 3600
Query: 3601 LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP 3639
LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP
Sbjct: 3601 LGSTAAQSLSPKLKAKPVSSLNECTTKDARPGCLLRSDP 3639
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 936 bits (2418), Expect = 0.0
Identities = 644/2109 (30%), Positives = 1031/2109 (48%), Gaps = 91/2109 (4%)
Query: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
+E I+ L +Q+KTFTKW+N+ + ++ +LY++L DG +LLRLLE++SG
Sbjct: 43 FERSRIKALADEREAVQKKTFTKWVNS--HLARVTCRVGDLYSDLRDGRNLLRLLEVLSG 100
Query: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
E LP P++GR+R+H LEN +AL FL+ KV + +G +IVDG+ L LGL+W IILRF
Sbjct: 101 EILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRF 160
Query: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
QI IS++ E+ + S K+ALL+WCQ KTA Y NVN+ +F+ SW DGL FNA++H
Sbjct: 161 QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHK 217
Query: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
HRPDLLD+ SL+ +NL AF +AE+ELG+ +LLDPEDV QPDE+SI+TYV+ YY
Sbjct: 218 HRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYY 277
Query: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
HY S++ +R+ K+L E E L +YE L ++LL+WI + + L R +SL
Sbjct: 278 HYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSL 337
Query: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
++ L +F +RT EKPP+ ++G E LLF +Q+ L+A N++ + P EG ++++++
Sbjct: 338 SGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINK 397
Query: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
W LE AE R AL+ L++ ++LE LA RF KAA+RE++L + ++++ Q
Sbjct: 398 AWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNF-GLE 456
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
LA VEAAV++ +E I+ GR QA+ +A L E+YH +A RQ V W L
Sbjct: 457 LAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL 516
Query: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
Q + +R+++ + + Q++ +EE++ +S G+ LA V +LLQ H+L+
Sbjct: 517 RQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELV 576
Query: 544 EAQVSAHGAHVSHLAQQTAEL----DSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
EA ++ V ++ +++ + L Q ++L L ARRA
Sbjct: 577 EADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
Query: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
LE++ + FL E EAW++E + +A GRDL+ L KH AL E+
Sbjct: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGP 696
Query: 660 CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
+ +G+ L A P RA +Q W+ L+ R RL A + Q+ ADA
Sbjct: 697 LKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA 756
Query: 720 AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
+ +WL + + G D+ + + L R+H LE +R+ L L EQ
Sbjct: 757 NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQ------- 809
Query: 780 ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
+A PP L P+ T L
Sbjct: 810 -------AAALPP-------------------------TLSRTPEVQGRVPT-------L 830
Query: 840 SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ--RVQPQADTLEVM 897
+ YE L+A A R LE A+AL+ S G LW+E++ L + + + LEV+
Sbjct: 831 ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 890
Query: 898 QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
Q ++E + V+ AEQL + P +I QE+L+ RW Q L K
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 958 AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017
L ++ + ++ EC TQ +R+ +E+ Q G D L L Q+K ER +
Sbjct: 951 KAALTSALSIQNYHLECTETQAWMREKTKVIESTQ-GLGNDLAGVLAL-QRKLAGTERDL 1008
Query: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQE-----QVAQRARRQAETQAR--Q 1070
+ + V ++ A + Q + L++VQ + R R ++ +AR Q
Sbjct: 1009 EAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ 1068
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQS 1130
FL+ W Q + S+E + A+ LL +H L E+ Q +L A
Sbjct: 1069 DFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
Query: 1131 QPMAALDC-PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
+ + P + L LG +EL +WE RQ L + Q F R+
Sbjct: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188
Query: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
++ + L + ++ A + +++ +F + G R L G +LV + A
Sbjct: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
+RE+ SI+ + + Q ++Q +L + + Q + QD EL W++EK L A
Sbjct: 1249 IREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE 1308
Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
RN+ ++H+A +EL A + ++ + + GREL +P + + +L+ L +W+ L
Sbjct: 1309 ARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDEL 1368
Query: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
+ L A + E + + LE L+ L S + G+DL S L K+ Q L
Sbjct: 1369 ETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML 1428
Query: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLE----LLQGHLAIRGLQLQASV 1485
E E ++ A+ + A +A E ++ R +E L + R +LQAS
Sbjct: 1429 EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488
Query: 1486 ELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
E HQF E+ WV E +P S + + L Q L +K++ LQ E++ H+ ++ +
Sbjct: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548
Query: 1546 SSGRSL-AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELE 1604
R+L AA+ P + EL+ W L E R + L+ A+ QQ++ D +E E
Sbjct: 1549 ERQRALGAAAAGP-------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
Query: 1605 GWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE 1664
W+ E+ + ++ +DE + + KHQ L++ LA Y ++ +L ++Q + E PE
Sbjct: 1602 AWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPE 1661
Query: 1665 QQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
R+ Q ++ + L+ELA R L+ LRL + RE +DL+ W+ +++
Sbjct: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI-QEREVVAASH 1720
Query: 1723 SLGEDPEHALHLCTKFAKFQHQVE-MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQ 1781
LG+D EH L KF +F +G +RV + LA L+ GH+A V + + L
Sbjct: 1721 ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLN 1780
Query: 1782 TAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLR 1841
AW++L EL RG L R + L +VQ K LP+ RDL EA R
Sbjct: 1781 EAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840
Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901
H E ++ Q+Q++ + R+QK G +A + + QAV +AWA LQ RR
Sbjct: 1841 RHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARR 1900
Query: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
L RF AVR+ W V + +E ++ SS L + Q ++AE+EAR
Sbjct: 1901 QLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARA 1960
Query: 1962 KLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
+ +G++ L + +E+ E+L LQ +R + + W K + LQ + +F R
Sbjct: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGR 2020
Query: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQD------KKEAALRE 2075
+ G E L +QE ++++ LG +V+EVE LI++HE F K A + +K AL E
Sbjct: 2021 DAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080
Query: 2076 RLKTLRRPR 2084
R K +R R
Sbjct: 2081 REKERKRKR 2089
Score = 499 bits (1284), Expect = e-140
Identities = 425/1715 (24%), Positives = 754/1715 (43%), Gaps = 70/1715 (4%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW L + R ALR T + ++ LE L ++ ++
Sbjct: 394 DINKAWERLEKAEHERELALR----TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVS 449
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
+N +L +EA +R H+ +E ++V ++Q + A + + H +++ R
Sbjct: 450 QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA----AERYHDIKRIAAR 505
Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
Q V + W L++ + RR +L L + + W ++ LQ ++ + +
Sbjct: 506 QHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAG 565
Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE--------VQEELRALQD 1994
L H+ + A++ + + + + L P KE V E + L+
Sbjct: 566 VEDLLQLHELVEADIAVQA----ERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQ 621
Query: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
+ + + A ++ RL+ ++ FL E G E + Q+ L ++ G + +L+
Sbjct: 622 SYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLN 681
Query: 2055 KHEVF----------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
KH LK+ Q ++ A + R + L + R++ LAE
Sbjct: 682 KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAE----LQAQWERLEALAE 737
Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
R L + + F A E W+ + + P D +H+A E E++
Sbjct: 738 ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIR 797
Query: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLE 2224
+H + ++ ++ AL + R EV R+ L +H+E+L+ R + LE
Sbjct: 798 SHRPTLDALREQAAAL-PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYT 856
Query: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISD 2284
L W++EKE +N L + LE +++R +T+ A I +++D
Sbjct: 857 MLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM--NTLA-AQITAVND 913
Query: 2285 LSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKR 2344
++ QL +P I + QLN+RW F + L AL I E
Sbjct: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
Query: 2345 IQEKEALIQALD-CGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
++EK +I++ G DL V L RK ER++ I A+V L RE L P A
Sbjct: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQA 1033
Query: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPA 2463
+ R +EV W LR+ ++R E+L + Q L + R + + +
Sbjct: 1034 VAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEG 1093
Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT-AGHPFSSDIRQVLAGLEQE 2522
P + EA +L +H + E++ S R+ G+++ P +RQ L L
Sbjct: 1094 PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTG 1153
Query: 2523 LSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWK 2582
L W+ Q +L QA Q FL + E L S+E L+ + L + + K
Sbjct: 1154 WEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKK 1213
Query: 2583 HKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR 2642
+ ++ +I L R L G+ A + ++ R + A R
Sbjct: 1214 LEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGR 1273
Query: 2643 LEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ 2702
L + R+ Q FLQD E+ W+ EK L A + + L + QK Q F AEL A+
Sbjct: 1274 LRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWL 1333
Query: 2703 QELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME 2762
++ +EG+ L + E+L +L W EL+ +Q K L A A +S
Sbjct: 1334 DKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCC 1393
Query: 2763 ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG 2822
LE+WLE ++ +L + G+ L V LL Q+ LE + + ++ EA+ QA+A +E
Sbjct: 1394 ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453
Query: 2823 HCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAA 2882
A +VE +R + ++F++L +P++ER L+A +F RD ++E+ WV E+LP+A+
Sbjct: 1454 QG-AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMAS 1512
Query: 2883 AQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL 2942
+ ++G+ L +V+ L +++Q L+ E+ HE + + G AA A +Q++
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPR---IADLRERQRALGAAAAGPELAELQEM 1569
Query: 2943 EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
K + H E R L+ A AQQF + EA +W+ E+ + ++ + QA
Sbjct: 1570 WKRLGH---ELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAE 1626
Query: 3003 LRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEAR 3062
+++ + ++ L ++ I +L ++ + ++PES ++ + V + +A L A R
Sbjct: 1627 VKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGER 1686
Query: 3063 GHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
LQE L+L QL RE L+ W+ + A S + GQD E V +L +KF F ++ ++
Sbjct: 1687 RERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTI 1746
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSF 3182
GQ +V + LA L G + + + AW L + + R + LAAA+E+ F
Sbjct: 1747 GQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRF 1806
Query: 3183 QQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACR 3242
A + R+Q K + + G L++ LQ++H E +++A+ +V ++Q + R
Sbjct: 1807 LHGARQALARVQHKQQQLP-DGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHR 1865
Query: 3243 LGQLHPAAPG-----GLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQE 3297
L + + + V EAWA LQ + R Q L F +EL+ W E
Sbjct: 1866 LQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Query: 3298 RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVT 3357
++E DV+ A+ ++ + + EI + G++L+ SH+ + E++
Sbjct: 1926 VNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEIS 1985
Query: 3358 ECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSV 3417
E L +L+ R QE E W + + + AEAWL E L+ + G +V
Sbjct: 1986 EKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2045
Query: 3418 SDVELLLHRHQDLEKLLAAQEEKFAQMQK-TEMEQ 3451
+VE L+ RH+ +K A EE+F ++K T +E+
Sbjct: 2046 DEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080
Score = 431 bits (1109), Expect = e-120
Identities = 407/1782 (22%), Positives = 760/1782 (42%), Gaps = 87/1782 (4%)
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQ--LQSIQAQWTRLQGRSEQRRRQ 1274
E G L L LRA+ +K+ +T RE + I W RL+ +R
Sbjct: 361 EKGNLEVLLFTIQSKLRANNQKV--------YTPREGRLISDINKAWERLEKAEHERELA 412
Query: 1275 LLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHEPSGARRNILQT-LKRHEAAES 1325
L L QE + +A W+ E + + + G ++ +++HEA E+
Sbjct: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
+++A V+A+ V EL + R + I R + W+ L + + R + L +
Sbjct: 473 DIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLE 532
Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
+++ + L + +E+++G LQS + G+ L + L + H+ +E++ A ++ A+++
Sbjct: 533 LQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSA 592
Query: 1446 MA-----HGMAASPA----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNM 1496
A G P + E K + E L A R +L+ S L +F
Sbjct: 593 SALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGE 652
Query: 1497 ELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGH 1556
+WV E + L GA L KH L+ E+ G ++ L G+ L A GH
Sbjct: 653 AEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGH 712
Query: 1557 PQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
P A + EL+ W LE E RAQ L QA + Q+ D +++E W+ + LVSS
Sbjct: 713 PGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSS 772
Query: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLR 1674
+ G DE +T L +H+AL+EE+ + +++ L + A L T PE Q V L
Sbjct: 773 PELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRV-PTLE 831
Query: 1675 EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHL 1734
LQ A R R LE L L+ L EA W+ +K+ G +L E E +
Sbjct: 832 RHYEELQARAGERARALEAALALYTMLSEAGACGLWV-EEKEQWLNGLALPERLEDLEVV 890
Query: 1735 CTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR 1794
+F + ++ + ++ A +AE LL+ + Q+ L W + L +
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 1795 GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTE 1854
AL + H + E ++EK V GL L L+R+L GTE
Sbjct: 951 KAALTSALSIQNYHLECTETQAWMREK-----TKVIESTQGLGNDLAGVLALQRKLAGTE 1005
Query: 1855 RQLQELLETAGRVQK----LCPG--PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR 1908
R L+ + G + + L G QA A+ R + V W L+ M +R L AR
Sbjct: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065
Query: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
L F ++ D+ +W R + + EE L+ H LR E+E + + +
Sbjct: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125
Query: 1969 QLGQQALLAAGTP-TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
LG++ P +++ L AL +++ + W +Q RL Q FLR+ + E
Sbjct: 1126 ALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAE 1185
Query: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------R 2081
+L++QE L + + +++ + I+K E F+ + A ++ L E + L
Sbjct: 1186 GVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIH 1245
Query: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
++R++ + +R + ++ A+ L + F Q + + WI + V
Sbjct: 1246 ADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE-KMLTAQDV 1304
Query: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
+ R+ KHQAF AE+ A+++ + V K+G L + VS++L+ L +
Sbjct: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRR 1364
Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
W++L + + L D F Q E+W++ + +++ D G+DL L ++
Sbjct: 1365 WDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKK 1424
Query: 2262 LREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRY 2321
+ A V + + +I + L D ++ R+ + ++ + +
Sbjct: 1425 QQMLEWEMA---VREKEVEAIQAQAKALAQEDQGAGEVERTSRA-VEEKFRALCQPMRER 1480
Query: 2322 QQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREV--- 2378
++L+ + E H R++++ + E+ + +++ GKDL SVQ L++K++ L++E+
Sbjct: 1481 CRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGH 1540
Query: 2379 HPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQ 2438
P A + +R +G PE A E+ E W +L + R + L+ +AQ
Sbjct: 1541 EPRIADLRERQRALG-AAAAGPELA--------ELQEMWKRLGHELELRGKRLEDALRAQ 1591
Query: 2439 KLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTG 2498
+ E M + + A+ +++HQ + L + +I ++
Sbjct: 1592 QFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASS 1651
Query: 2499 QQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLC 2558
Q ++ HP S+ I A +++ + L+ E + +LQ+ L L ++ +E+W+
Sbjct: 1652 QDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQ 1711
Query: 2559 SKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEATARGLHQGGHPEAQS 2617
+E AS L + L K + D + ++ + A A GL GGH A++
Sbjct: 1712 EREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH-AARA 1770
Query: 2618 ALGRCQAMLLRKEA-LFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL 2676
+ + L A L TR L +LQ FL +++ A ++ K +
Sbjct: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR 1830
Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWG 2735
D A ++ ++ ++ A Q Q++Q +G RL + +E I ++ + W
Sbjct: 1831 DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWA 1890
Query: 2736 ELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQR 2795
+LQ +S + L + R +++ EL W++ + +++ A + + ++ Q+
Sbjct: 1891 QLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Query: 2796 ELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALE 2855
++A ++ +A + + + + + H A+++ E+ +L R + E QE+ L+
Sbjct: 1951 GIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQ 2010
Query: 2856 ARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
+L F RDA AW+ + PL + + G ++ V L ++H+ + + E
Sbjct: 2011 LVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--- 2067
Query: 2916 VVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957
F A E +++ EK R E RR+
Sbjct: 2068 -------------RFCALEKLTALEEREKERKRKREEEERRK 2096
Score = 335 bits (858), Expect = 6e-91
Identities = 397/1733 (22%), Positives = 699/1733 (40%), Gaps = 154/1733 (8%)
Query: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV-- 653
R+ LEQ R F R E WL E + V G +L+ + A++KH+A+E ++
Sbjct: 419 RQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476
Query: 654 HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
+ + VD V +L+A R R V W L+ V R RL L +
Sbjct: 477 YSGRVQAVDAV--AAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
Query: 714 QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
+ F D W+ E + L+ G+ A E LL+ H +E A++ E+
Sbjct: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVE-------ADIAVQAERV 587
Query: 774 RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
RA SA A F C+PG K P DP +
Sbjct: 588 RAVSASALRF-----------------------CNPG-----KEYRPC------DPQLVS 613
Query: 834 QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADT 893
+ L Q YE+L LA RRARLEE+ L+ F GE + W+ +Q LL D
Sbjct: 614 ERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDL 673
Query: 894 LEVMQLKYENFLTAL-AVGKGLWAEVSSSAEQ----LRQRYPGNSTQIQRQQEELSQRWG 948
++L N TAL G + + EQ + + +PG ++Q + EL +W
Sbjct: 674 TGALRLL--NKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG-ASQASARAAELQAQWE 730
Query: 949 QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQK 1008
+LEAL E+A +LA + + F + + L D L + + + G E + AL Q
Sbjct: 731 RLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL-ARQH 789
Query: 1009 KTLVLERRVHFLQSVVVKVE----EPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
+ L E R H ++ + P + + +QG+V TL+ +++Q + +RAR
Sbjct: 790 RALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALE 849
Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
A + L E+ LW E + L + + + + + + L E++ ++
Sbjct: 850 AALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQIT 909
Query: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
++ ++ + + P + NT L + Q+ + L + ++ L L +Q + E
Sbjct: 910 AVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLE--- 966
Query: 1185 FTATCANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHG 1236
C QAW+ LG D+ L+L ++ R L + R L
Sbjct: 967 ----CTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREA 1022
Query: 1237 EKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM- 1295
L A + +L+ +Q W L+ +R L + +LQ++ + + + W+
Sbjct: 1023 NALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLG 1082
Query: 1296 EEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQ-ED 1354
+ +A+ E L +H A E+ + L+ +G E+ + Q
Sbjct: 1083 RTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142
Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414
++ RL+ L + WE L R R L QA + LR + A+ L E L +E
Sbjct: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
Query: 1415 DLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHLR 1465
L+++ K+ + S ++ L ++ G + I E+ ++H +
Sbjct: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262
Query: 1466 RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH- 1524
+ Q L +L+ + E F + W+ E M SY E A++LH
Sbjct: 1263 NQDAAQQFLG----RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE----ARNLHT 1314
Query: 1525 --RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEA 1582
+KH+ E+ A++ + +V GR L + E+ ++L W ELE +A
Sbjct: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQA 1374
Query: 1583 RAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAI 1642
+A+ L A + + LE W+E + + S DYG+D + L+ K Q L+ E+A+
Sbjct: 1375 KARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAV 1434
Query: 1643 YWSSMEELDQTAQTLT-----GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRL 1697
+E + A+ L EV R V+E+ R + ++E R R L+ +
Sbjct: 1435 REKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE----RCRRLQASREQ 1490
Query: 1698 HEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRL 1757
H+F R+ ED W+ + A E G+D L K Q +++ R+A R
Sbjct: 1491 HQFHRDVEDEILWVTERLPMASSMEH-GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRE 1549
Query: 1758 LAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
+L +AGP + +LQ W L + RG L D + +RD E
Sbjct: 1550 RQRAL--GAAAAGPEL----AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAW 1603
Query: 1818 V-QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLC--PGP 1874
+ +++ + A+D +A+++ HQ LE+ L + + +L A Q + P
Sbjct: 1604 MGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQL---AASSQDMIDHEHP 1660
Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVE 1934
++ + RQ V + +A L+ +RR +L+ L + R + D W Q+ +V
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI----QEREVV 1716
Query: 1935 ESSQEPSSG-----PLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEEL 1989
+S E L+ ++ R ++ A L L+A G +
Sbjct: 1717 AASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALA-NGLIAGGHAAR------ 1769
Query: 1990 RALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEIL-----AAQEVSLKTSAL-- 2042
+ + +D + + WA E L Q L L+ L A V K L
Sbjct: 1770 ATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
Query: 2043 --GSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
G + E L R+H + + A + +++ L++ D+ + + V
Sbjct: 1827 GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVA 1886
Query: 2101 EL-AESRG-HALHASLLMAS-----FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
E A+ +G A LL+ + F +A + W+ Q+ P D+ +
Sbjct: 1887 EAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVI 1946
Query: 2154 LKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRG 2213
Q +AE++A + +S G+ LLA+SH A E+S++L L+ ++ + +
Sbjct: 1947 KNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKM 2006
Query: 2214 QELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
L+ L F + +AEAW+ +E + +LG ++ L +R F+
Sbjct: 2007 DWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQ 2059
Score = 295 bits (756), Expect = 4e-79
Identities = 402/1834 (21%), Positives = 756/1834 (41%), Gaps = 137/1834 (7%)
Query: 1281 LQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
+++++ +EL+QW+E+ A+ SG + N LQ+ + E T +
Sbjct: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQ-NQLQSFNSYRTVEKPPKFTEKG-- 363
Query: 1336 ALQQVGRELLSRRPCGQEDIQTRLQG-----LRSKWEALNRKMTERGDELQQAGQQEQLL 1390
L+ + + S+ + + T +G + WE L + ER L+ +++ L
Sbjct: 364 NLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKL 423
Query: 1391 RQLQDAKEQ--------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
QL ++ L + + + G +L + + ++H+ +E++ + ++ A
Sbjct: 424 EQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQA 483
Query: 1443 LASMAHGMAASP----AILEETQKHLRRL-ELLQGHLAIRGLQLQASVELHQFCHLSNME 1497
+ ++A +AA + Q ++ RL + L+ +A R +L ++EL +
Sbjct: 484 VDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL 543
Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557
+ W+ E L G + L + H+ ++ ++ +V+ V +S G
Sbjct: 544 MDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKE 603
Query: 1558 ----QAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPL 1613
Q + E+ +LE + L AR L+++ ++ +V E E WV E++ L
Sbjct: 604 YRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHL 663
Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP--EQQRVVQE 1671
++S D GRD LRL+NKH AL+ E++ ++ + Q L P Q
Sbjct: 664 LASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA 723
Query: 1672 RLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHA 1731
L+ Q L+ LA R + L L++F +A D++ WL + E LG D
Sbjct: 724 ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE-LGHDEFST 782
Query: 1732 LHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
L + + ++ + A R A +L S P V+ R L+ + EL
Sbjct: 783 QALARQHRALEEEIRSHRPTLDALREQAAALPPT-LSRTPEVQGRVPTLERHYEEL---- 837
Query: 1792 QAR-GHALRDTETTLRVHRDLLEVLT---QVQEKATSLPNNVA--RDLCGLEAQLRSHQG 1845
QAR G R E L ++ L E V+EK L N +A L LE + +
Sbjct: 838 QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL-NGLALPERLEDLEVVQQRFET 896
Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
LE E+ Q+ + + A ++ K P P + Q+ + W +R + ++A L
Sbjct: 897 LEPEMNTLAAQITAVNDIAEQLLKANP-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALT 955
Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR-EKLW 1964
A + + + +W +R+ +V ES+Q + + A Q A E E +
Sbjct: 956 SALSIQNYHLECTETQAW---MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIA 1012
Query: 1965 QQATQLGQQA-LLAAGTPTKEV--QEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
+ +L ++A LAAG P + V LR +Q + + T R++E L ++ Q FLR
Sbjct: 1013 ARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLR 1072
Query: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR 2081
+ L + ++ + +++ E E L+ +H L + ++ + RL+ L
Sbjct: 1073 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAA----LRGEVERAQSEYSRLRALG 1128
Query: 2082 RPRVRDRL-PILLQRRMRVKELA----------ESRGHALHASLLMASFTQAATQAEDWI 2130
RD+ P L R R++ L ESR L + F + A QAE +
Sbjct: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188
Query: 2131 QAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE 2190
+ L PG L+ + K + F + + A+ E + + + G L+++ + A +
Sbjct: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
Query: 2191 VSQRLQGL-RKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
+ ++ + R+H ++ A G+ L D R FLQ + WI EK + D+
Sbjct: 1249 IREKADSIERRHKKNQDAAQQFLGR-LRDNREQQHFLQDCHELKLWIDEK--MLTAQDVS 1305
Query: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309
D L + ++ + A + + +L PE ++ ++ L+
Sbjct: 1306 YD--EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHR 1363
Query: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369
RW + L A + ++ + ++ +A + + D GKDL SV LL+
Sbjct: 1364 RWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLK 1423
Query: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
K + LE E+ + +VE+++ + L Q + A + + V E + L ++R
Sbjct: 1424 KQQMLEWEMAVREKEVEAIQAQAKALAQED-QGAGEVERTSRAVEEKFRALCQPMRERCR 1482
Query: 2430 ALDALHQAQKLQAMLQ-ELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWT 2488
L A + + ++ E+L +RL P + +++++Q + E+
Sbjct: 1483 RLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP-SVQLLMKKNQTLQKEIQGHE 1541
Query: 2489 DSISLARSTGQQL-LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
I+ R + L A P ++++++ L EL L G +L+ AL Q F
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE-LRGK------RLEDALRAQQFY 1594
Query: 2548 SSVEKMERWLCSKE-DSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARG 2606
+ E W+ +E + E D L+ + KH++LE L A I L A+++
Sbjct: 1595 RDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK-KHQVLEQALADYAQTIHQLAASSQD 1653
Query: 2607 LHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK 2666
+ HPE+ R + L AG RR RL+E +L ++ ++ W++E+
Sbjct: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
Query: 2667 NLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQRE-GQRLLQGGHPASEAIQ 2724
+VA L D + K + F + ++ + L+ GGH A +
Sbjct: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
Query: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQAL 2784
E + L W +L + + L A E R + R Q L
Sbjct: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQ---------ALARVQHKQQQL 1824
Query: 2785 PGVGELLGTQRELEAAVDKKARQA------EALLGQAQAFVREGHCL--------AQDVE 2830
P GT R+L AA + R +AL Q Q +GH L A+++
Sbjct: 1825 PD-----GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
+ + + + L+ RR L + +FF+ E M W+ E AQ+ + +
Sbjct: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
Query: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
S+ + + Q +++E+ + + G +L+ H+AA E++ ++ QL+
Sbjct: 1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQ------- 1992
Query: 2951 AEAARRRLLLQQAQEAQQFLTELLE----------AGSWLAERGHVLDSEDMGHSAEATQ 3000
ARR+ ++ QE +L +LE A +WL + ++ S ++G + + +
Sbjct: 1993 ---ARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVE 2049
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRK 3034
+L++R EA ++ A+ R L++ AL E K
Sbjct: 2050 SLIKRHEAFQKSAVAWEERFCALEKLTALEEREK 2083
Score = 269 bits (687), Expect = 4e-71
Identities = 317/1399 (22%), Positives = 573/1399 (40%), Gaps = 84/1399 (6%)
Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL---RDKLKPLLKH 2156
K + + HA+ A L+ + A++ WI+ L + L +++L+ +
Sbjct: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
Query: 2157 QAFE-----AEVQAHEEVMTSVAKKGEALLAQSH-PRAGEVSQRLQGLRKHWEDLRQA-- 2208
+ E E E ++ ++ K A + + PR G + + + K WE L +A
Sbjct: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRL---ISDINKAWERLEKAEH 407
Query: 2209 ---MALRGQELEDRRNFLE-----FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRR 2260
+ALR + + R+ LE F ++ + E W+ E + ++ + G +L +
Sbjct: 408 ERELALRTELI--RQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLEL---AAVEA 462
Query: 2261 RLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLR 2320
+R+ ++++ ++ +L ++K I R+ + W +
Sbjct: 463 AVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAA 522
Query: 2321 YQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHP 2380
+++L LE+ + ++L + ++E + +Q+ D G+ L V+ LL+ HE +E ++
Sbjct: 523 RRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAV 582
Query: 2381 IQAQVESLEREVGRLC-----------QRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
+V ++ R C Q E L + + E R+R ++ R
Sbjct: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
Query: 2430 ALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
L + + +A ++E Q L A DT R A R+L +H + E+
Sbjct: 643 LWRFLWEVGEAEAWVRE----QQHLLASADTG---RDLTGALRLLNKHTALRGEMSGRLG 695
Query: 2490 SISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSS 2549
+ L GQQL+ GHP +S A L+ + LE +E +L QA L F +
Sbjct: 696 PLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQAD 755
Query: 2550 VEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ 2609
ME WL ++S L + L +H+ LE ++ + AL A L
Sbjct: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815
Query: 2610 --GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
PE Q GR + E L +AG R LE L L ++ W+ EK
Sbjct: 816 TLSRTPEVQ---GRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKE 872
Query: 2667 ---NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
N +AL E L D L Q+ + + E++ Q + ++LL+ P + I
Sbjct: 873 QWLNGLALPERLED---LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRI 929
Query: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWL-EPIEVELRAPTVGQ 2782
E+L W + + + K A L A E + W+ E +V +G
Sbjct: 930 VNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGN 989
Query: 2783 ALPGV----GELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
L GV +L GT+R+LEA A + L +A A A + + R +
Sbjct: 990 DLAGVLALQRKLAGTERDLEAI----AARVGELTREANALAAGHPAQAVAINARLREVQT 1045
Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
++ LR ++ R +L L F R D+ AW+ A+++ +L L
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
Query: 2899 QHQNL--ESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARR 2956
QH L E E + E LG QA + R++ L L R
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF-LRQRLEALGTGWEELGRMWESR 1164
Query: 2957 RLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
+ L QA Q FL + +A L+ + +VL +M + +A A +++LE ++A
Sbjct: 1165 QGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDAN 1224
Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
RI L + L S N + K+ + ++ H + A+ L++ +
Sbjct: 1225 GERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGT 3136
++ L W+ K TA+ Y + + +K AF E+ + + + + K
Sbjct: 1285 QDCHELKLWIDEKMLTAQDVSY-DEARNLHTKWQKHQAFMAEL-AANKDWLDKVDKEGRE 1342
Query: 3137 LERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK 3196
L P + + + W+ L+ +A+ +L A+ F Q+ L+ ++
Sbjct: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
Query: 3197 TALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK 3256
A + +D G L+SV L ++ + LE E+ EKEV +Q +A L Q A G + +
Sbjct: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA-GEVER 1461
Query: 3257 ----VQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVA 3312
V+E + L +ER + L + + H F ++ + W ER +ASS E +D+
Sbjct: 1462 TSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP 1521
Query: 3313 GAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRL-QELE 3371
+ L+ +++ L +EI+ + DLR+ + L + E+ E LQE+ RL ELE
Sbjct: 1522 SVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL--GAAAAGPELAE-LQEMWKRLGHELE 1578
Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
LR +R ++ Q+ + +AEAW+ E ++ + + + +HQ LE
Sbjct: 1579 ----LRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLE 1634
Query: 3432 KLLAAQEEKFAQMQKTEME 3450
+ LA + Q+ + +
Sbjct: 1635 QALADYAQTIHQLAASSQD 1653
Score = 241 bits (615), Expect = 1e-62
Identities = 377/1841 (20%), Positives = 706/1841 (38%), Gaps = 131/1841 (7%)
Query: 706 LQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAE 765
++ LV +Y + A+E W+ + +L + + L+ V +
Sbjct: 301 MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKP---- 356
Query: 766 LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDP 825
+ E+G + LFT+ S L + + P E AW+ AE +
Sbjct: 357 -PKFTEKG---NLEVLLFTIQSKLRANNQKVYTP---REGRLISDINKAWERLEKAEHER 409
Query: 826 DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ 885
+ T L +R+ +LE+ A F ++ E L ++ V
Sbjct: 410 ELALRTEL------------------IRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
Query: 886 RVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQ 945
+ +E K+E T + G V + A +L + +I +Q +++
Sbjct: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
Query: 946 RWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG----SSEDTCH 1001
W L + + +L ++E+ Q+ + ++ +L++ G ED
Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571
Query: 1002 ALQLAQKKTLVLERRVHFLQSVVVKVEEPGY----AESQPLQGQVETLQGLLKQVQEQVA 1057
+L + V RV + + ++ PG + Q + +V L+ + + E A
Sbjct: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
Query: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIH 1117
R R E++ FL E + W Q L S + D+ A RLL +H L E+
Sbjct: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
Query: 1118 LWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177
L+ Q Q + A P + + L Q + L+ L E+R Q L + L +
Sbjct: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
Query: 1178 FGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGE 1237
F + + A + + LG D +L +QHR + + P +ALR
Sbjct: 752 FQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAA 811
Query: 1238 KL--VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM 1295
L S+ P V+ ++ +++ + LQ R+ +R R L A+L L + W+
Sbjct: 812 ALPPTLSRTP---EVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWV 868
Query: 1296 EEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED 1354
EEK R L+ + +R E E E+ + A+ + +LL P G++
Sbjct: 869 EEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDR 928
Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE-TG 1413
I + L +W+ R + L A + + + + + + ++S++ G
Sbjct: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL----E 1468
DL LQ++ E + +AA++ L A+ +AA PA LR + E
Sbjct: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
Query: 1469 LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHK 1528
L+ + R L + L F + +W+ + L A++L +H
Sbjct: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
Query: 1529 ELQVEVKAHQGQVQRVLSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCL 1587
L+ EV+ Q + R+ + G + PQ + ++ + L W EL R E+R L
Sbjct: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 1588 QQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSM 1647
QA FQ + D + EG ++SS++Y + A ++L + S+M
Sbjct: 1169 AQAHGFQGFLRDARQAEG-------VLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTM 1221
Query: 1648 EELDQTAQTL--TGPEVPEQQRVVQERLREQLRAL-------QELAATRDRELEGTLRLH 1698
+ + L G ++ + + +++RE+ ++ Q+ A L
Sbjct: 1222 DANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ 1281
Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
FL++ +L+ W+ + A + + D LH TK+ K HQ M +AA +
Sbjct: 1282 HFLQDCHELKLWIDEKMLTA---QDVSYDEARNLH--TKWQK--HQAFMA--ELAANKDW 1332
Query: 1759 AESLLERGH-------SAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
+ + + G +V ++ +DL W EL TQA+ +L D +
Sbjct: 1333 LDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSC 1392
Query: 1812 LEVLTQVQEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKL 1870
+ + ++ L ++ +DL + L+ Q LE E+ E++++ + A + +
Sbjct: 1393 CALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQE 1452
Query: 1871 CPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQD 1930
G A V++ +AV + + L + M +R +L+ +R +F V D W
Sbjct: 1453 DQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPM 1510
Query: 1931 LQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELR 1990
E ++ S L + +Q L+ E++ E + + AA P EL
Sbjct: 1511 ASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGP------ELA 1564
Query: 1991 ALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVE 2050
LQ+ ++ + +RL+ + Q F R+ E + QE+ + +
Sbjct: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ 1624
Query: 2051 QLIRKHEVFLKVLT--AQDKKE-AALRERLKTLRRP---RVRDRLPILLQRRMRVKELAE 2104
++KH+V + L AQ + AA + + P R+ R + + +KELA
Sbjct: 1625 AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAG 1684
Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQ-----AWAQQLKEPVPPGD-LRDKLKPLLKHQA 2158
R L L + + E WIQ A + +L + LRDK + + +
Sbjct: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744
Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
+E + S L+A H V++ L + W DL + + RGQ L
Sbjct: 1745 -----TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799
Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
FL A A +Q K+ ++ G G+DL L+RR + + +
Sbjct: 1800 AYELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAYEHDIQALS---PQ 1855
Query: 2279 IRSISDLSLQL-KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRE 2337
++ + D +L K ++ + I + + WA G+ +Q L + +
Sbjct: 1856 VQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1915
Query: 2338 LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQ 2397
+ + + E + A + +D+ S +++ + ++ E+ + S L
Sbjct: 1916 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLA 1975
Query: 2398 RSPEAAH-------GLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML--QELL 2448
RS AA L+ R+QE AE W + Q E L A +A L QE L
Sbjct: 1976 RSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPL 2035
Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
V + L +D E +++ H+ + +W +
Sbjct: 2036 VRSAELGCTVD---------EVESLIKRHEAFQKSAVAWEE 2067
Score = 241 bits (615), Expect = 1e-62
Identities = 273/1311 (20%), Positives = 524/1311 (39%), Gaps = 86/1311 (6%)
Query: 406 FLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHS 465
++++ EQ L+ A P L +E QR LE + + A+ +IA+ L +
Sbjct: 867 WVEEKEQWLN-GLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPG 925
Query: 466 WADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARST- 524
+ QE++ RWQ+ + G++ + ++ + E + E + ST
Sbjct: 926 KDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
Query: 525 ACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
G LA V+ L ++ E + A A V L ++ L + + A+ R +
Sbjct: 986 GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045
Query: 585 LQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
+ L A +R R L + + +FLR+ ++ +AWL V + L + L
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
Query: 645 KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-----ERAEAVQGGWQLLQTRV 699
+H AL EV R Q+ L G +++ Q DP +R EA+ GW+ L
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFLRQRLEALGTGWEELGRMW 1161
Query: 700 VGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVL 759
R RL A + DA +A L + L H + L
Sbjct: 1162 ESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-----------------HTEMPGTL 1204
Query: 760 RAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMAL 819
+A A +++LE+ A L G L + G
Sbjct: 1205 QAADAAIKKLEDFMSTMDANGERI---HGLLEAGRQLVSEG------------------- 1242
Query: 820 PAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEK 879
+ + I + D + + ++ + AQ RL + F C EL+LW+++
Sbjct: 1243 ------NIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE 1296
Query: 880 QTVLLQRVQ-PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQR 938
+ + Q V +A L K++ F+ LA K +V +L P +
Sbjct: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
Query: 939 QQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSED 998
+ +L +RW +LE + KA L + F Q C + L + QL + G
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
Query: 999 TCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVE----TLQGLLKQVQE 1054
+ + L L +++ L E V + ++ + A+ G+VE ++ + + +
Sbjct: 1417 SVNIL-LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQ 1475
Query: 1055 QVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLE 1114
+ +R RR ++ + F ++ + +LW S E D+ S Q L++++Q L +
Sbjct: 1476 PMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQK 1535
Query: 1115 EIHLWQERLQQLDAQSQPM-AALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL 1173
EI + R+ L + + + AA P+ E+ + LG + E R + L++ L
Sbjct: 1536 EIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE-------LELRGKRLEDAL 1588
Query: 1174 ELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
Q+F R+ A + + +D A + +++H+ + L+ L
Sbjct: 1589 RAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLA 1648
Query: 1234 AHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
A + ++ +HP + + + + + L+ + +RR +L L+L + ++++ +L Q
Sbjct: 1649 ASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQ 1708
Query: 1294 WMEEKGLMAAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCG 1351
W++E+ ++AA G + L K E + + V++ + L++
Sbjct: 1709 WIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAA 1768
Query: 1352 QEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE 1411
+ + L W L + RG L A + ++ L + A +++ + L
Sbjct: 1769 RATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG- 1827
Query: 1412 TGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRLE- 1468
TG+DL +++ LQ+RH E + + L+ ++ + H + + A EE +H++ +
Sbjct: 1828 TGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAE 1887
Query: 1469 ---LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHR 1525
LQG A R L + + +F + W+ E ++ A + +
Sbjct: 1888 AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIK 1947
Query: 1526 KHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQ 1585
+ ++ E++A + + G+ L A H A+ I E+ +L+ E + +
Sbjct: 1948 NQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMD 2007
Query: 1586 CLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWS 1645
LQ + + D E W+ + PLV S + G LI +H+A Q+ A+ W
Sbjct: 2008 WLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS-AVAW- 2065
Query: 1646 SMEELDQTAQTLTGPEVPEQQRV---VQERLREQLRALQELAATRDRELEG 1693
EE + LT E E++R +E R+Q A + A+ +L G
Sbjct: 2066 --EERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 930 bits (2404), Expect = 0.0
Identities = 616/2131 (28%), Positives = 1062/2131 (49%), Gaps = 89/2131 (4%)
Query: 8 GHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEAL 67
G ++LQ +Q+KTFTKW+N+ + +I +LYT+L DG L++LLE++SGE L
Sbjct: 30 GRFKQLQDEREAVQKKTFTKWVNS--HLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 87
Query: 68 PPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRFQIS 126
P P++GR+R+H LEN +AL FL+ +V + +G +IVDG+ L LGLIW IILRFQI
Sbjct: 88 PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 147
Query: 127 HISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRP 186
IS++ E+ + S K+ALL+WCQ KTA Y NVNI +F+ SW DG+ FNALIH HRP
Sbjct: 148 DISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRP 204
Query: 187 DLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYC 246
DL+D+ L+ +NL AF +AEQ LG+ +LLDPED++ PDE+SI+TYV YYHY
Sbjct: 205 DLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYF 264
Query: 247 SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
S++ +R+ K+L ETE + +YE L +DLL WI + + L R F +SL +
Sbjct: 265 SKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGV 324
Query: 307 RQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366
+Q L AF +RT EKPP+ ++G E LLF +Q+ ++A N++ ++P EG ++++++ W
Sbjct: 325 QQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWE 384
Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q L
Sbjct: 385 RLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFDLPA 443
Query: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQH 486
VEAA ++ +E I E R QA+ +A L E YH + R++ V W+ LL+
Sbjct: 444 VEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLEL 503
Query: 487 LQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQ 546
L+ +R+++ + + QE+ ++E++ S G+ L V +LLQ+H L+EA
Sbjct: 504 LRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEAD 563
Query: 547 VSAHGAHVSHL---AQQTA-ELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQ 602
+ V + AQ+ A + + +V++ + + Q L L RRA LE+
Sbjct: 564 IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEE 623
Query: 603 TLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVD 662
+ + +F EEE W++E + + + G+DL+ + L KH+A E E+
Sbjct: 624 SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQ 683
Query: 663 LVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEA 722
++ G D+ A ER ++ W L+ R RL+ A L+ Q+ ADA +
Sbjct: 684 AIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDI 743
Query: 723 ASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASL 782
+W+ + + + G D+ + ++L+++H + + + L L EQ A
Sbjct: 744 DAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL------ 797
Query: 783 FTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQD 842
P E +P S + +
Sbjct: 798 ---------PQEHAESPDVRGRLS-------------------------------GIEER 817
Query: 843 YESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLK 900
Y+ + L +LR+ L++ +AL+ S +LW++++ L +Q + + LEV+Q +
Sbjct: 818 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877
Query: 901 YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQ 960
+E+ + A V+ A QL + +I+ QQ++L+ RW Q L K
Sbjct: 878 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937
Query: 961 LAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------LVLE 1014
L ++ + ++ EC T+ +R+ +E+ Q D + L +K T + +E
Sbjct: 938 LLSALSIQNYHLECNETKSWIREKTKVIESTQ-DLGNDLAGVMALQRKLTGMERDLVAIE 996
Query: 1015 RRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQ 1074
++ LQ K+E ++Q + ++ + + ++++ + R E Q FL+
Sbjct: 997 AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLR 1056
Query: 1075 ESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
+ W Q + S+++ + A++LL +H+++ EI ++E Q++ + M
Sbjct: 1057 DLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MV 1115
Query: 1135 ALDCPDSQE--VPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH 1192
D+Q + L+ L EL +WE RQ L + Q+F R+ A N
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1175
Query: 1193 QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVRE 1252
+ L + + A + +++ +F + + A+ G +LV + + ++E
Sbjct: 1176 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1235
Query: 1253 QLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRN 1312
++ SI + + + + + +L + LQ++ QD EL W+ EK L A RN
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN 1295
Query: 1313 ILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRK 1372
+ +H+A +EL + + ++ +++ G +L+S +P + ++ +L GL WE L
Sbjct: 1296 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLEST 1355
Query: 1373 MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESE 1432
+ L A + E + D + L LE +QS + G+DL S L K+ Q LE++
Sbjct: 1356 TQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQ 1415
Query: 1433 SRTLAAKMAALASMAHGMAASPAILEETQK-----HLRRLELLQGHLAIRGLQLQASVEL 1487
++ L S A ++ +E + +ELL+ L R L AS E+
Sbjct: 1416 MEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLE-PLNERKHNLLASKEI 1474
Query: 1488 HQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSS 1547
HQF E+ WV E MP + T + L Q L +K++ LQ E++ HQ ++ +
Sbjct: 1475 HQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534
Query: 1548 GRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
+++ S A+ I ++ +L+ W L E R + L++A QQY+ D +E E W
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1594
Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
+ E+ + S + +DE + + ++ KHQ L++ + Y ++ +L +T++ L PE +
Sbjct: 1595 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE 1654
Query: 1667 RVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESL 1724
R+ Q ++ + L++LA R +L+ RL + RE +DL+ W+A +++ G L
Sbjct: 1655 RISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA-EREVVAGSHEL 1713
Query: 1725 GEDPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
G+D EH L +F +F +G +RV LA+ L+ GHS + + + L A
Sbjct: 1714 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1773
Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
W++L EL R L + + + D E+ ++Q+K LP + RD +E R H
Sbjct: 1774 WADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMH 1833
Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQ 1903
E ++ Q+++L E A R+Q G +A +Q+R+ V +AW L E RR +
Sbjct: 1834 TTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVR 1893
Query: 1904 LERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKL 1963
L RF + VRD W V + ++ +E ++ SS L ++ HQ ++AE++AR
Sbjct: 1894 LVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDS 1953
Query: 1964 WQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLREC 2023
+ +LG+ L ++E++E+L L ++R ++ W + E L+ + F R+
Sbjct: 1954 FTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDA 2013
Query: 2024 GRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP 2083
E L QE L + +G SV+EVE+LI++HE F K D++ +AL ERL TL
Sbjct: 2014 SVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTLELL 2072
Query: 2084 RV--------RDRLPILLQRRMRVKELAESR 2106
V R R P + +V E AES+
Sbjct: 2073 EVRRQQEEEERKRRPPSPEPSTKVSEEAESQ 2103
Score = 537 bits (1384), Expect = e-152
Identities = 423/1727 (24%), Positives = 797/1727 (46%), Gaps = 72/1727 (4%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW L + R ALR+ + ++ LE L + ++ ++
Sbjct: 378 DINKAWERLEKAEHERELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 433
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
+N DL +EA + H+ +E ++ E ++Q ++ A ++ H +++ R
Sbjct: 434 QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELE----AENYHDIKRITAR 489
Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
+ V + W L + RR +LE L + + W ++ + ++ +
Sbjct: 490 KDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLG 549
Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE-----VQEELRALQDQRD 1997
L H + A++ + + + Q G K +++ + ++
Sbjct: 550 VEDLLQKHTLVEADIGIQAER-VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 608
Query: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
++ Q A ++ RL+ ++ F E E + +E L + G + V +L+ KH
Sbjct: 609 ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 668
Query: 2058 VFLKVLTAQDKK-EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRGHALH 2111
F ++ + E A++E + ++R+R+ + ++ +++L+ R L
Sbjct: 669 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 728
Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL-RDKLKP---LLKHQAFEAEVQAHE 2167
+ L+ F A D I AW + + V D+ D+ + KH+ E+ +
Sbjct: 729 EASLLHQFQADA----DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 784
Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQ 2227
+ ++ ++ AL Q H + +V RL G+ + ++++ + LR Q L+D +
Sbjct: 785 PTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 843
Query: 2228 RVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSL 2287
D E WI EKE +N + + LE ++ R A + I+ +
Sbjct: 844 EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLM 903
Query: 2288 QLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQE 2347
+ +E+K ++ +LN RW+ F + R + L AL I E + I+E
Sbjct: 904 HSGHPSEKEIKA---QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIRE 960
Query: 2348 KEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
K +I++ D G DL V L RK +ER++ I+A++ L++E +L P+ A +
Sbjct: 961 KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020
Query: 2407 RHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPA 2463
R E+++ W ++++ K REA +L +A KLQ L++L R + + +
Sbjct: 1021 LSRLAEISDVWEEMKTTL-KNREA--SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1077
Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQ 2521
P + EA ++L +H+ K E+D++ + R G+ ++T G + +RQ L L+
Sbjct: 1078 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRLQALDT 1136
Query: 2522 ELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW 2581
+ L W+ Q L Q+ Q FL ++ E +L ++E LA + L E +
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIK 1196
Query: 2582 KHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRH 2641
K + ++ KI+A+ T R L G+ + + ++ R A
Sbjct: 1197 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1256
Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
RL++ R LQ FLQD QE++ W+ EK L A + + L ++ K Q F AEL ++
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1316
Query: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
++++EG +L+ ++E+L L +W L+ +Q K +L A +A +S
Sbjct: 1317 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSC 1376
Query: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
+L+ WL +E ++++ G+ L V LL Q+ LE ++ + ++ E L QAQA +E
Sbjct: 1377 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1436
Query: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLA 2881
G +V+ + + +F L EPL ER+ L A + +F RD ++E+ WV E++PLA
Sbjct: 1437 GKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLA 1495
Query: 2882 AAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLV-QAGHFAAHEVAARVQ 2940
+ D+G +L V+ L +++Q L+ E+ H+ + +V + +A + R+
Sbjct: 1496 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1555
Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
L++ L E +R L++A AQQ+ + EA +W++E+ + SE+ ++
Sbjct: 1556 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1615
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
++L++ + ++ +E ++ + +L +T+ L + +PES ++ + V + +A L AE
Sbjct: 1616 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1675
Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
R L E+ +L QL RE L+ W+ + A S + GQD E V +L+E+F F ++
Sbjct: 1676 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1735
Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
++GQ +V + LA L I + + AW L + I RT+ LAA++E+H
Sbjct: 1736 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1795
Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
F A E+ GR+Q+K + E+ G ++V TLQ+ H E +++A+ +V +LQ +A
Sbjct: 1796 KFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA 1854
Query: 3241 CRLGQLHPAAPGGLA--------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELL 3292
R L A G A +V EAW +L + R L F ++L+
Sbjct: 1855 AR---LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM 1911
Query: 3293 AWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFM 3352
W ++ ++E DV+ E L+ H+ + EI + G+ L+ H+
Sbjct: 1912 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYA 1971
Query: 3353 SAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPD 3412
S E+ E L +L + +E+ + W RW+ + + + AEAWL E L +
Sbjct: 1972 SEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2031
Query: 3413 YGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQE 3459
G SV +VE L+ RH+ EK A +E+F+ +++ + L ++ Q+
Sbjct: 2032 IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQ 2078
Score = 435 bits (1119), Expect = e-121
Identities = 369/1699 (21%), Positives = 748/1699 (44%), Gaps = 62/1699 (3%)
Query: 1254 LQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHE 1305
+ I W RL+ +R L L QE + +A W+ E + + +
Sbjct: 376 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 435
Query: 1306 PSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
G ++ K+HEA E+++ A V+A+ V REL + + I R +
Sbjct: 436 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR 495
Query: 1365 KWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK 1424
WE L + R L+ +++ +++ + +++++ + S + G+ L + L +
Sbjct: 496 LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQ 555
Query: 1425 RHQQLESESRTLAAKMAALASMAHGMAAS--------PAILEETQKHLRRL--ELLQGHL 1474
+H +E++ A ++ + + A A P ++ + H+ EL Q
Sbjct: 556 KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ-LA 614
Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
A R +L+ S L +F E W+ E S Y + L L KH+ + E+
Sbjct: 615 AERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEM 674
Query: 1535 KAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQ 1594
G ++ + G + A H ++ I E+ + WA LE+ R + L++A
Sbjct: 675 SGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 734
Query: 1595 QYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
Q+ D +++ W+ + +VSS D G DE +T L+ KH+ + EE+A Y +++ L + A
Sbjct: 735 QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 794
Query: 1655 QTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
L P+V + ++ER +E + EL R + L+ TL L++ EA+ +
Sbjct: 795 SALPQEHAESPDVRGRLSGIEERYKE----VAELTRLRKQALQDTLALYKMFSEADACEL 850
Query: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
W+ +K+ + E E + +F + ++ + RVA +A L+ GH +
Sbjct: 851 WI-DEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS 909
Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-- 1827
++ +Q L T WS+ EL + AL + H + E + ++EK + +
Sbjct: 910 EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 969
Query: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
++ DL G+ A R G+ER+LV E +L +L + A +++ P QA A+ R ++
Sbjct: 970 DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEIS 1028
Query: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
W ++ ++ R A L A L +F + D+ SW +R + + E+ + L
Sbjct: 1029 DVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1088
Query: 1948 SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWA 2004
+ H+ ++ E++ E+ +Q+ +G+ ++ G + +++ L+AL +++++ W
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE 1146
Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
+Q L Q FLR+ + E L QE L + + +++E E I+K E F+ +
Sbjct: 1147 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMD 1206
Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
A ++K A+ E + L R+++++ + R + +E A L + +
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1266
Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
F Q + WI + + + R+ LKHQAF AE+ +++E + + K+G
Sbjct: 1267 FLQDCQELSLWINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM 1325
Query: 2179 ALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQE 2238
L+++ V ++L GL K WE L + Q L D F Q + W+
Sbjct: 1326 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHG 1385
Query: 2239 KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLK--NRDPEE 2296
E ++ D G+DL L ++ + + + I +L Q + +++ +
Sbjct: 1386 LESQIQSDDYGKDLTSVNILLKKQQMLENQM------EVRKKEIEELQSQAQALSQEGKS 1439
Query: 2297 VKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD 2356
+ +R + ++ L + L + EIH +R++++ + E+ L + D
Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499
Query: 2357 CGKDLESVQRLLRKHEELEREVHPIQAQVESL-EREVGRLCQRSPEAAHGLRHRQQEVAE 2415
G +L++VQ L++K++ L++E+ Q +++ + ER + S +A +R R ++ +
Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1559
Query: 2416 SWWQLRSRAQKRREALDALHQAQK--LQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRM 2473
W L +KR L+ H+AQ+ A E +S Q L M + + A M
Sbjct: 1560 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL--YMMSEEKAKDEQSAVSM 1617
Query: 2474 LEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH 2533
L++HQ + ++ + +++ T + L+ HP S I + +++ + L+ +E
Sbjct: 1618 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1677
Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL-EV 2592
+ +L + L V+ +E+W+ +E S L + L + + D +
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737
Query: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
++ + A L GH +A + + L TR L +L F
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797
Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRL 2712
D++E+ +++K+ EE D + + F+ ++ A Q ++LQ + R
Sbjct: 1798 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR- 1856
Query: 2713 LQGGHPASEA--IQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
LQ + +A IQ+R E+ W L D + + +L + R + +L W+E
Sbjct: 1857 LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1916
Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE 2830
+ ++ A + + V L+ + ++A +D + + ++ + H +++++
Sbjct: 1917 VIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1976
Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
E+ +L ++ K + + ++R L + +F RDA AW+ + P ++++ GQS+
Sbjct: 1977 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV 2036
Query: 2891 SAVRHLQEQHQNLESEMSS 2909
V L ++H+ E ++
Sbjct: 2037 DEVEKLIKRHEAFEKSAAT 2055
Score = 392 bits (1006), Expect = e-108
Identities = 381/1789 (21%), Positives = 759/1789 (42%), Gaps = 75/1789 (4%)
Query: 868 SSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL-- 925
S +L W+E QT+++ + A++L +Q + + F T V K + E L
Sbjct: 296 SLASDLLEWIE-QTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 354
Query: 926 --RQRYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECG 975
+ + N+ ++ +E ++++ W +LE + E+ + L + + E L
Sbjct: 355 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRF 414
Query: 976 PTQVQLRDVLLQLEALQPGSSEDT----CHALQLAQKKTLVLE-------RRVHFLQSVV 1024
+ +R+ L Q S+D A++ A KK +E RV + +V
Sbjct: 415 DRKAAMRETWLSEN--QRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVA 472
Query: 1025 VKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAE 1084
++E Y + + + + + + L + + E + R +R Q QE ++ W +
Sbjct: 473 RELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 532
Query: 1085 SVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAA-----LDCP 1139
++ + S++ + + LL++H + +I + ER++ ++A +Q A C
Sbjct: 533 EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC- 591
Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1199
D Q + + + + QEL L +R+ L+E L KF E+ + L D
Sbjct: 592 DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD 651
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
+ G+D+ + LL +HR F +S E GE ++ +H + +RE++ I+
Sbjct: 652 DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIRE 711
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-K 1318
QW L+ S R+++L + L +++ D ++ WM + + + G Q+L K
Sbjct: 712 QWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 771
Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
+H+ E+ R ++ L + L + D++ RL G+ +++ + R
Sbjct: 772 KHKDVAEEIANYRPTLDTLHEQA-SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 830
Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
LQ ++ + + +++ E L + + + L + +Q R + LE E A+
Sbjct: 831 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS 890
Query: 1439 KMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
++A + +A + S E + ++ Q L R Q + V+ + LS + +
Sbjct: 891 RVAVVNQIARQLMHSGHPSE------KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSI 944
Query: 1499 -----------SWVAEHMP-HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLS 1546
SW+ E S L G +L RK ++ ++ A + ++ +
Sbjct: 945 QNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQK 1004
Query: 1547 SGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
L + QAQ I+ + E+ W E++ + R L +A QQ+ D+ + + W
Sbjct: 1005 EAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSW 1064
Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
+ + ++S D +L+ +H+ ++ E+ Y +++ + +T + Q
Sbjct: 1065 LSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQY 1124
Query: 1667 RVVQERLR---EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
+++RL+ L ++ R L + +FLR+ + + +L +Q+ E
Sbjct: 1125 MFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE- 1183
Query: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
+ E A K F ++ +++ A L+ G+ ++++ +
Sbjct: 1184 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR 1243
Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
+ E L+D + +D E+ + EK + + + L ++ H
Sbjct: 1244 HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKH 1303
Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRA 1902
Q EL + L + +E G +Q + P+ A V+++ + + W VL+ + +
Sbjct: 1304 QAFMAELASNKEWLDK-IEKEG-MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1361
Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
+L A F + D W + +Q ++ ++ +S + L Q L ++E R+K
Sbjct: 1362 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1421
Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE 2022
++ Q QAL G T EV + +Q + ++ + ++ L A ++ F R+
Sbjct: 1422 EIEE-LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1480
Query: 2023 CGRLEEIL-AAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-- 2078
+EIL + + L TS G +++ V+ LI+K++ K + + + ER +
Sbjct: 1481 VE--DEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1538
Query: 2079 -----TLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
+L +R RL L Q + E E R L + + A +AE W+
Sbjct: 1539 VTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQ 1598
Query: 2134 AQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ 2193
+ D + + L KHQ E V+ + E + ++K AL+A SHP + +S
Sbjct: 1599 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISM 1658
Query: 2194 RLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
R + K + L+ R +L++R + + VD E WI E+EV +LGQD E
Sbjct: 1659 RQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYE 1718
Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
H L+ R REF ++ +G + +++ L+ +L N + I + + LN WA
Sbjct: 1719 HVTMLQERFREFARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1776
Query: 2314 FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
+ Q L + E+H + + RIQ+K + + G+D +V+ L R H
Sbjct: 1777 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTT 1835
Query: 2374 LEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
E ++ + QV L+ + RL + + A ++ R+ EV E+W L + RR L
Sbjct: 1836 FEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLV 1895
Query: 2433 ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSIS 2492
+ +M+++L++ + + Q++ PR ++ HQ KAE+D+ DS +
Sbjct: 1896 DTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFT 1955
Query: 2493 LARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK 2552
G+ LL H S +I++ L L ++ + W++ L+ LE+ F
Sbjct: 1956 TCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASV 2015
Query: 2553 MERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
E WL +E L+S + + +E L+ +H+ E + SALE
Sbjct: 2016 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALE 2064
Score = 301 bits (770), Expect = 1e-80
Identities = 366/1758 (20%), Positives = 702/1758 (39%), Gaps = 137/1758 (7%)
Query: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
R+ LEQ +R F R E WL E + V G DL + A +KH+A+E ++
Sbjct: 403 RQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA 460
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
++ +V R+L A R + V W+ L + R RL+ L + +
Sbjct: 461 YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKI 520
Query: 716 FADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRA 775
F + W+ E + + G+ E LL++H +E A++ E+ R
Sbjct: 521 FQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE-------ADIGIQAERVRG 573
Query: 776 ASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQT 835
+A A F + G+ +K DP I
Sbjct: 574 VNASAQKFATD-------------------------GEGYKPC---------DPQVIRDR 599
Query: 836 QDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLE 895
H+ Y+ L LA RRARLEE+ L+ F E + W+ ++ +L D
Sbjct: 600 VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 659
Query: 896 VMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL 953
VM+L K+ F ++ G + + E + S +I+ + + ++W LE L
Sbjct: 660 VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 719
Query: 954 KREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
+ +L + + F + + D+L + + G E + + L +K V
Sbjct: 720 SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS--LVKKHKDVA 777
Query: 1014 ERRVHFLQSVVVKVEEPG-----YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQA 1068
E ++ ++ E+ +AES ++G++ ++ K+V E R + +T A
Sbjct: 778 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837
Query: 1069 RQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
E+ LW + + L + ++ + + + + L E++ R+ ++
Sbjct: 838 LYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQ 897
Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
++ + P +E+ L + + + L ++++ L L +Q + E
Sbjct: 898 IARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE------- 950
Query: 1189 CANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
C ++W+ +LG D+ ++L ++ R L + + L+ EKL
Sbjct: 951 CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL- 1009
Query: 1241 QSQHP-AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
+S+HP A + +L I W ++ + R L + +LQ++ +D+ + W+ +
Sbjct: 1010 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1069
Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQ-- 1356
+A+ + + L +HE ++E+ + ++ +G E++++ GQ D Q
Sbjct: 1070 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQ---GQTDAQYM 1125
Query: 1357 ---TRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
RLQ L + W L++ R + L Q+ +Q LR + A+ L E L +E
Sbjct: 1126 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1185
Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHL 1464
L ++ K+ + + K+ A+ ++ G S I E+ +H
Sbjct: 1186 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1245
Query: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
+ E L ++L+ + +L +F W+ E M SY E N S
Sbjct: 1246 KNRETASELL----MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN-LHSKW 1300
Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEAR 1583
KH+ E+ +++ + ++ G L S P+ + +V E+ L W LE + +
Sbjct: 1301 LKHQAFMAELASNKEWLDKIEKEGMQL-ISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1359
Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
AQ L A + + ++L+ W+ + S DYG+D + L+ K Q L+ ++ +
Sbjct: 1360 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1419
Query: 1644 WSSMEELDQTAQTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
+EEL AQ L + EV ++ VQ + E L L E R L + +H
Sbjct: 1420 KKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE----RKHNLLASKEIH 1475
Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
+F R+ ED W+ + A + G + + L K Q +++ R+
Sbjct: 1476 QFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534
Query: 1759 AESLLERGHS-AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
+++++ S + +RQR DL+ W L E T+ R L + + + D E
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1594
Query: 1818 VQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQA 1876
+ E+ + A+D + L+ HQ LE+ + + +L +T+ R P++
Sbjct: 1595 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS-RALVADSHPES 1653
Query: 1877 HAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEES 1936
+ RQ V + +A L+ E+RR +L+ L + V D W A
Sbjct: 1654 ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA----------- 1702
Query: 1937 SQEPSSGPLKLSAHQWLRAELEAREKLWQQAT-QLGQQALLAAGTPTKEV----QEELRA 1991
+E +G +L L+ R + + + T +GQ+ + E+ +
Sbjct: 1703 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAAT 1762
Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRL----EEILAAQEVSLK--TSALGSS 2045
+ + +D + + WA E + Q E + +EI + K LG
Sbjct: 1763 IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRD 1822
Query: 2046 VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKE---- 2101
VE L R H F + A + L+E L+ D+ + +R V E
Sbjct: 1823 QNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKS 1882
Query: 2102 ---LAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
ESR L + F W++ +Q++ P D+ + HQ
Sbjct: 1883 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1942
Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
+AE+ A + T+ + G++LLA+ H + E+ ++L L + +++ R + L
Sbjct: 1943 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2002
Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
+F + +AEAW+ +E ++ ++GQ ++ +L +R F ++A +
Sbjct: 2003 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2062
Query: 2279 IRSISDLSLQLKNRDPEE 2296
+ ++ L L R EE
Sbjct: 2063 LERLTTLELLEVRRQQEE 2080
Score = 167 bits (422), Expect = 2e-40
Identities = 174/832 (20%), Positives = 336/832 (40%), Gaps = 81/832 (9%)
Query: 480 WQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
W+ L Q + +++ D Q L L+ +S G+ L V LL++
Sbjct: 1349 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1408
Query: 540 HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
+LE Q+ + L Q L S G S + + +K T+ L+ + R+
Sbjct: 1409 QQMLENQMEVRKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN 1467
Query: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
L + + +F R+ E+E W+ E + G +L + ++K++ L+ E+ HQ
Sbjct: 1468 LLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPR 1527
Query: 660 CVDLVRRGRDLSARRPPTQPDP-GERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
D+ R +++ + +R ++ W LL R RL+ A QY+ D
Sbjct: 1528 IDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFD 1587
Query: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
AAEA +W+ E+ + +D+ +A ++L++H LE+ + +A + +L + RA A
Sbjct: 1588 AAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVA 1647
Query: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
+ HP + I Q
Sbjct: 1648 DS---------------------------HP------------------ESERISMRQSK 1662
Query: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQPQADTLEV 896
+ + Y L+ LA+ RR +L+E LF +L+ W+ ++ V+ + + + +
Sbjct: 1663 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM 1722
Query: 897 MQLKYENFLTALA-VGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKR 955
+Q ++ F +G+ V+ A++L ++ I ++ L++ W L L
Sbjct: 1723 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1782
Query: 956 EKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLER 1015
+ LA S E+ F + +++D +L + G ++T LQ + E
Sbjct: 1783 TRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQ---RMHTTFEH 1838
Query: 1016 RVHFLQSVVVKVEEPG------YA--ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
+ L + V +++E YA ++ +Q + + K + + R R +T
Sbjct: 1839 DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG 1898
Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLD 1127
+ F + L+LW E V Q+ ++E DV+S + L+ HQ + EI +
Sbjct: 1899 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI 1958
Query: 1128 AQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA 1187
+ + A S+E+ L L ++ +E+ WE R +WL+ LE+ +F R+ A
Sbjct: 1959 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2018
Query: 1188 TCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAA 1247
+ +L +G+ V E L+++H F + +T R AL
Sbjct: 2019 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL--------------- 2063
Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKG 1299
E+L +++ R Q E+R+R+ + + ++ QW KG
Sbjct: 2064 ----ERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKG 2111
Score = 148 bits (374), Expect = 8e-35
Identities = 141/613 (23%), Positives = 263/613 (42%), Gaps = 26/613 (4%)
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
A+E ++ K+ A + + W+++ + + + + SL V+ Q Q N +
Sbjct: 284 AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQ-QLQAFNTYRTVEKPPK 342
Query: 2913 LT-----RVVLGTGYKLVQAGHFAAH---------EVAARVQQLEKAMAHLRAEAARRRL 2958
T V+L T ++A + + ++ ++LEKA H R A R L
Sbjct: 343 FTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA-EHERELALRNEL 401
Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
+ Q+ E A++F + +WL+E ++ ++ G A +A ++ EA + D+ A+
Sbjct: 402 IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAY 461
Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
R++ + A LE+ + ++ A+ V LL AR L+ L L ++
Sbjct: 462 EERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIF 521
Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE--VQSLGQAKVYALRKLA 3134
+E L + W+ SQDYG+ L GV+ L +K + +Q+ V A +
Sbjct: 522 QEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKF 581
Query: 3135 GTLERGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
T G P + R + +E ++ L Q R L + + F AE +G +
Sbjct: 582 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 641
Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA-CRLGQLHPAAP- 3251
+EK ++ +D G L+SV L +HR E E+ + E + + H +
Sbjct: 642 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 701
Query: 3252 --GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAE 3309
+ ++E WA L+ + R + L +A+ H F ++ AW + ++ SS ++
Sbjct: 702 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH 761
Query: 3310 DVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQE 3369
D + L+ +H+++ +EI R L ++ L H S +V L +E R +E
Sbjct: 762 DEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKE 820
Query: 3370 LEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQD 3429
+ E LR Q ++ L K+ + E W+ E L + D+E++ HR +
Sbjct: 821 VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES 880
Query: 3430 LEKLLAAQEEKFA 3442
LE + Q + A
Sbjct: 881 LEPEMNNQASRVA 893
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 929 bits (2401), Expect = 0.0
Identities = 616/2134 (28%), Positives = 1062/2134 (49%), Gaps = 89/2134 (4%)
Query: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
+E I+ L +Q+KTFTKW+N+ + +I +LYT+L DG L++LLE++SG
Sbjct: 40 FERSRIKALADEREAVQKKTFTKWVNS--HLARVSCRITDLYTDLRDGRMLIKLLEVLSG 97
Query: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
E LP P++GR+R+H LEN +AL FL+ +V + +G +IVDG+ L LGLIW IILRF
Sbjct: 98 ERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRF 157
Query: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
QI IS++ E+ + S K+ALL+WCQ KTA Y NVNI +F+ SW DG+ FNALIH
Sbjct: 158 QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHK 214
Query: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
HRPDL+D+ L+ +NL AF +AEQ LG+ +LLDPED++ PDE+SI+TYV YY
Sbjct: 215 HRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYY 274
Query: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
HY S++ +R+ K+L ETE + +YE L +DLL WI + + L R F +SL
Sbjct: 275 HYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSL 334
Query: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
++Q L AF +RT EKPP+ ++G E LLF +Q+ ++A N++ ++P EG ++++++
Sbjct: 335 VGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINK 394
Query: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
W LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q
Sbjct: 395 AWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF-GFD 453
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
L VEAA ++ +E I E R QA+ +A L E YH + R++ V W+ L
Sbjct: 454 LPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYL 513
Query: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
L+ L+ +R+++ + + QE+ ++E++ S G+ L V +LLQ+H L+
Sbjct: 514 LELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV 573
Query: 544 EAQVSAHGAHVSHL---AQQTA-ELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
EA + V + AQ+ A + + +V++ + + Q L L RRA
Sbjct: 574 EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 633
Query: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
LE++ + +F EEE W++E + + + G+DL+ + L KH+A E E+
Sbjct: 634 LEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGH 693
Query: 660 CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
++ G D+ A ER ++ W L+ R RL+ A L+ Q+ ADA
Sbjct: 694 FEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA 753
Query: 720 AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
+ +W+ + + + G D+ + ++L+++H + + + L L EQ A
Sbjct: 754 DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL--- 810
Query: 780 ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
P E +P S +
Sbjct: 811 ------------PQEHAESPDVRGRLS-------------------------------GI 827
Query: 840 SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQ--PQADTLEVM 897
+ Y+ + L +LR+ L++ +AL+ S +LW++++ L +Q + + LEV+
Sbjct: 828 EERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVI 887
Query: 898 QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
Q ++E+ + A V+ A QL + +I+ QQ++L+ RW Q L K
Sbjct: 888 QHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRK 947
Query: 958 AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------L 1011
L ++ + ++ EC T+ +R+ +E+ Q D + L +K T +
Sbjct: 948 KDALLSALSIQNYHLECNETKSWIREKTKVIESTQ-DLGNDLAGVMALQRKLTGMERDLV 1006
Query: 1012 VLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQS 1071
+E ++ LQ K+E ++Q + ++ + + ++++ + R E Q
Sbjct: 1007 AIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQ 1066
Query: 1072 FLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQ 1131
FL++ W Q + S+++ + A++LL +H+++ EI ++E Q++ +
Sbjct: 1067 FLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE 1126
Query: 1132 PMAALDCPDSQE--VPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
M D+Q + L+ L EL +WE RQ L + Q+F R+ A
Sbjct: 1127 -MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1185
Query: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
N + L + + A + +++ +F + + A+ G +LV + +
Sbjct: 1186 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR 1245
Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
++E++ SI + + + + + +L + LQ++ QD EL W+ EK L A
Sbjct: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305
Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
RN+ +H+A +EL + + ++ +++ G +L+S +P + ++ +L GL WE L
Sbjct: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVL 1365
Query: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
+ L A + E + D + L LE +QS + G+DL S L K+ Q L
Sbjct: 1366 ESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQML 1425
Query: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQK-----HLRRLELLQGHLAIRGLQLQAS 1484
E++ ++ L S A ++ +E + +ELL+ L R L AS
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLE-PLNERKHNLLAS 1484
Query: 1485 VELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRV 1544
E+HQF E+ WV E MP + T + L Q L +K++ LQ E++ HQ ++ +
Sbjct: 1485 KEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI 1544
Query: 1545 LSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL 1603
+++ S A+ I ++ +L+ W L E R + L++A QQY+ D +E
Sbjct: 1545 FERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA 1604
Query: 1604 EGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP 1663
E W+ E+ + S + +DE + + ++ KHQ L++ + Y ++ +L +T++ L P
Sbjct: 1605 EAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1664
Query: 1664 EQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGG 1721
E +R+ Q ++ + L++LA R +L+ RL + RE +DL+ W+A +++ G
Sbjct: 1665 ESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA-EREVVAGS 1723
Query: 1722 ESLGEDPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDL 1780
LG+D EH L +F +F +G +RV LA+ L+ GHS + + + L
Sbjct: 1724 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1783
Query: 1781 QTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQL 1840
AW++L EL R L + + + D E+ ++Q+K LP + RD +E
Sbjct: 1784 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1843
Query: 1841 RSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR 1900
R H E ++ Q+++L E A R+Q G +A +Q+R+ V +AW L E R
Sbjct: 1844 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1903
Query: 1901 RAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
R +L RF + VRD W V + ++ +E ++ SS L ++ HQ ++AE++AR
Sbjct: 1904 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1963
Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFL 2020
+ +LG+ L ++E++E+L L ++R ++ W + E L+ + F
Sbjct: 1964 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2023
Query: 2021 RECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL 2080
R+ E L QE L + +G SV+EVE+LI++HE F K D++ +AL ERL TL
Sbjct: 2024 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL 2082
Query: 2081 RRPRV--------RDRLPILLQRRMRVKELAESR 2106
V R R P + +V E AES+
Sbjct: 2083 ELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQ 2116
Score = 563 bits (1452), Expect = e-160
Identities = 475/1960 (24%), Positives = 875/1960 (44%), Gaps = 144/1960 (7%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW L + R ALR+ + ++ LE L + ++ ++
Sbjct: 391 DINKAWERLEKAEHERELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
+N DL +EA + H+ +E ++ E ++Q ++ A ++ H +++ R
Sbjct: 447 QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELE----AENYHDIKRITAR 502
Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
+ V + W L + RR +LE L + + W ++ + ++ +
Sbjct: 503 KDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLG 562
Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE-----VQEELRALQDQRD 1997
L H + A++ + + + Q G K +++ + ++
Sbjct: 563 VEDLLQKHTLVEADIGIQAER-VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 621
Query: 1998 QVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHE 2057
++ Q A ++ RL+ ++ F E E + +E L + G + V +L+ KH
Sbjct: 622 ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681
Query: 2058 VFLKVLTAQDKK-EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRGHALH 2111
F ++ + E A++E + ++R+R+ + ++ +++L+ R L
Sbjct: 682 AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741
Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL-RDKLKP---LLKHQAFEAEVQAHE 2167
+ L+ F A D I AW + + V D+ D+ + KH+ E+ +
Sbjct: 742 EASLLHQFQADA----DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 797
Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQ 2227
+ ++ ++ AL Q H + +V RL G+ + ++++ + LR Q L+D +
Sbjct: 798 PTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 856
Query: 2228 RVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSL 2287
D E WI EKE +N + + LE ++ R A + I+ +
Sbjct: 857 EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLM 916
Query: 2288 QLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQE 2347
+ +E+K ++ +LN RW+ F + R + L AL I E + I+E
Sbjct: 917 HSGHPSEKEIKA---QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIRE 973
Query: 2348 KEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
K +I++ D G DL V L RK +ER++ I+A++ L++E +L P+ A +
Sbjct: 974 KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1033
Query: 2407 RHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPA 2463
R E+++ W ++++ K REA +L +A KLQ L++L R + + +
Sbjct: 1034 LSRLAEISDVWEEMKTTL-KNREA--SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1090
Query: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQ 2521
P + EA ++L +H+ K E+D++ + R G+ ++T G + +RQ L L+
Sbjct: 1091 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRLQALDT 1149
Query: 2522 ELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW 2581
+ L W+ Q L Q+ Q FL ++ E +L ++E LA + L E +
Sbjct: 1150 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIK 1209
Query: 2582 KHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRH 2641
K + ++ KI+A+ T R L G+ + + ++ R A
Sbjct: 1210 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1269
Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ 2701
RL++ R LQ FLQD QE++ W+ EK L A + + L ++ K Q F AEL ++
Sbjct: 1270 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1329
Query: 2702 QQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSM 2761
++++EG +L+ ++E+L L +W L+ +Q K +L A +A +S
Sbjct: 1330 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSC 1389
Query: 2762 EELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
+L+ WL +E ++++ G+ L V LL Q+ LE ++ + ++ E L QAQA +E
Sbjct: 1390 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1449
Query: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLA 2881
G +V+ + + +F L EPL ER+ L A + +F RD ++E+ WV E++PLA
Sbjct: 1450 GKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLA 1508
Query: 2882 AAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLV-QAGHFAAHEVAARVQ 2940
+ D+G +L V+ L +++Q L+ E+ H+ + +V + +A + R+
Sbjct: 1509 TSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLA 1568
Query: 2941 QLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
L++ L E +R L++A AQQ+ + EA +W++E+ + SE+ ++
Sbjct: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
++L++ + ++ +E ++ + +L +T+ L + +PES ++ + V + +A L AE
Sbjct: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1688
Query: 3061 ARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQ 3120
R L E+ +L QL RE L+ W+ + A S + GQD E V +L+E+F F ++
Sbjct: 1689 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1748
Query: 3121 SLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVH 3180
++GQ +V + LA L I + + AW L + I RT+ LAA++E+H
Sbjct: 1749 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1808
Query: 3181 SFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA 3240
F A E+ GR+Q+K + E+ G ++V TLQ+ H E +++A+ +V +LQ +A
Sbjct: 1809 KFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA 1867
Query: 3241 CRLGQLHPAAPGGLA--------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELL 3292
R L A G A +V EAW +L + R L F ++L+
Sbjct: 1868 AR---LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM 1924
Query: 3293 AWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFM 3352
W ++ ++E DV+ E L+ H+ + EI + G+ L+ H+
Sbjct: 1925 LWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYA 1984
Query: 3353 SAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPD 3412
S E+ E L +L + +E+ + W RW+ + + + AEAWL E L +
Sbjct: 1985 SEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSRE 2044
Query: 3413 YGHSVSDVELLLHRHQDLEKLLAAQEEKFA-----------QMQKTEMEQELLLQPQELK 3461
G SV +VE L+ RH+ EK A +E+F+ ++++ + E+E +P +
Sbjct: 2045 IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPE 2104
Query: 3462 PGRAGS--SLTSFQWRPS-----GHQGLGAQ-----LAETRD------------------ 3491
P S + + QW S GL A+ +AET D
Sbjct: 2105 PSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKES 2164
Query: 3492 ------------------------PQDAKGTPT--MEGSLEFKQHLLPGGRQPSSSSWDS 3525
P + TP+ MEG L K ++ SS SW +
Sbjct: 2165 SPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHN 2224
Query: 3526 CRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGAE 3583
+ + + D + AA + S + L A CE +KH F LRL G E
Sbjct: 2225 VYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNE 2284
Query: 3584 ILFAAPSEEQAESWWRALGSTAA---QSLSPKLKAKPVSS 3620
LF A +E+ +W +A+ S + +S ++ P SS
Sbjct: 2285 YLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASS 2324
Score = 436 bits (1121), Expect = e-121
Identities = 394/1832 (21%), Positives = 794/1832 (43%), Gaps = 89/1832 (4%)
Query: 1254 LQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHE 1305
+ I W RL+ +R L L QE + +A W+ E + + +
Sbjct: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448
Query: 1306 PSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRS 1364
G ++ K+HEA E+++ A V+A+ V REL + + I R +
Sbjct: 449 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR 508
Query: 1365 KWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK 1424
WE L + R L+ +++ +++ + +++++ + S + G+ L + L +
Sbjct: 509 LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQ 568
Query: 1425 RHQQLESESRTLAAKMAALASMAHGMAAS--------PAILEETQKHLRRL--ELLQGHL 1474
+H +E++ A ++ + + A A P ++ + H+ EL Q
Sbjct: 569 KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ-LA 627
Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
A R +L+ S L +F E W+ E S Y + L L KH+ + E+
Sbjct: 628 AERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEM 687
Query: 1535 KAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQ 1594
G ++ + G + A H ++ I E+ + WA LE+ R + L++A
Sbjct: 688 SGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 747
Query: 1595 QYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
Q+ D +++ W+ + +VSS D G DE +T L+ KH+ + EE+A Y +++ L + A
Sbjct: 748 QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 807
Query: 1655 QTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
L P+V + ++ER +E + EL R + L+ TL L++ EA+ +
Sbjct: 808 SALPQEHAESPDVRGRLSGIEERYKE----VAELTRLRKQALQDTLALYKMFSEADACEL 863
Query: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
W+ +K+ + E E + +F + ++ + RVA +A L+ GH +
Sbjct: 864 WI-DEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPS 922
Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-- 1827
++ +Q L T WS+ EL + AL + H + E + ++EK + +
Sbjct: 923 EKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 982
Query: 1828 NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
++ DL G+ A R G+ER+LV E +L +L + A +++ P QA A+ R ++
Sbjct: 983 DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEIS 1041
Query: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
W ++ ++ R A L A L +F + D+ SW +R + + E+ + L
Sbjct: 1042 DVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1101
Query: 1948 SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWA 2004
+ H+ ++ E++ E+ +Q+ +G+ ++ G + +++ L+AL +++++ W
Sbjct: 1102 TQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE 1159
Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
+Q L Q FLR+ + E L QE L + + +++E E I+K E F+ +
Sbjct: 1160 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMD 1219
Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
A ++K A+ E + L R+++++ + R + +E A L + +
Sbjct: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
F Q + WI + + + R+ LKHQAF AE+ +++E + + K+G
Sbjct: 1280 FLQDCQELSLWINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM 1338
Query: 2179 ALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQE 2238
L+++ V ++L GL K WE L + Q L D F Q + W+
Sbjct: 1339 QLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHG 1398
Query: 2239 KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLK--NRDPEE 2296
E ++ D G+DL L ++ + + + I +L Q + +++ +
Sbjct: 1399 LESQIQSDDYGKDLTSVNILLKKQQMLENQM------EVRKKEIEELQSQAQALSQEGKS 1452
Query: 2297 VKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD 2356
+ +R + ++ L + L + EIH +R++++ + E+ L + D
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
Query: 2357 CGKDLESVQRLLRKHEELEREVHPIQAQVESL-EREVGRLCQRSPEAAHGLRHRQQEVAE 2415
G +L++VQ L++K++ L++E+ Q +++ + ER + S +A +R R ++ +
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1572
Query: 2416 SWWQLRSRAQKRREALDALHQAQK--LQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRM 2473
W L +KR L+ H+AQ+ A E +S Q L M + + A M
Sbjct: 1573 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL--YMMSEEKAKDEQSAVSM 1630
Query: 2474 LEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH 2533
L++HQ + ++ + +++ T + L+ HP S I + +++ + L+ +E
Sbjct: 1631 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1690
Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL-EV 2592
+ +L + L V+ +E+W+ +E S L + L + + D +
Sbjct: 1691 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750
Query: 2593 QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAF 2652
++ + A L GH +A + + L TR L +L F
Sbjct: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1810
Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRL 2712
D++E+ +++K+ EE D + + F+ ++ A Q ++LQ + R
Sbjct: 1811 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR- 1869
Query: 2713 LQGGHPASEA--IQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
LQ + +A IQ+R E+ W L D + + +L + R + +L W+E
Sbjct: 1870 LQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1929
Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE 2830
+ ++ A + + V L+ + ++A +D + + ++ + H +++++
Sbjct: 1930 VIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1989
Query: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
E+ +L ++ K + + ++R L + +F RDA AW+ + P ++++ GQS+
Sbjct: 1990 EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV 2049
Query: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
V L ++H+ E ++ + F+A E ++ LE
Sbjct: 2050 DEVEKLIKRHEAFEKSAATWDE----------------RFSALERLTTLELLEVRRQQEE 2093
Query: 2951 AEAARR-------RLLLQQAQEAQQFLT---ELLEAGSWLAERGHVLDSEDMGHSAEATQ 3000
E RR + ++A+ QQ+ T E + AE+G +E + ++E
Sbjct: 2094 EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETV-DTSEMVN 2152
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032
+ ++K SP +R +TA +S
Sbjct: 2153 GATEQRTSSKESSPIPSPTSDRKAKTALPAQS 2184
Score = 392 bits (1006), Expect = e-108
Identities = 381/1789 (21%), Positives = 759/1789 (42%), Gaps = 75/1789 (4%)
Query: 868 SSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL-- 925
S +L W+E QT+++ + A++L +Q + + F T V K + E L
Sbjct: 309 SLASDLLEWIE-QTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
Query: 926 --RQRYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECG 975
+ + N+ ++ +E ++++ W +LE + E+ + L + + E L
Sbjct: 368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRF 427
Query: 976 PTQVQLRDVLLQLEALQPGSSEDT----CHALQLAQKKTLVLE-------RRVHFLQSVV 1024
+ +R+ L Q S+D A++ A KK +E RV + +V
Sbjct: 428 DRKAAMRETWLSEN--QRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVA 485
Query: 1025 VKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAE 1084
++E Y + + + + + + L + + E + R +R Q QE ++ W +
Sbjct: 486 RELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 545
Query: 1085 SVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAA-----LDCP 1139
++ + S++ + + LL++H + +I + ER++ ++A +Q A C
Sbjct: 546 EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC- 604
Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1199
D Q + + + + QEL L +R+ L+E L KF E+ + L D
Sbjct: 605 DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD 664
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
+ G+D+ + LL +HR F +S E GE ++ +H + +RE++ I+
Sbjct: 665 DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIRE 724
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-K 1318
QW L+ S R+++L + L +++ D ++ WM + + + G Q+L K
Sbjct: 725 QWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVK 784
Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
+H+ E+ R ++ L + L + D++ RL G+ +++ + R
Sbjct: 785 KHKDVAEEIANYRPTLDTLHEQA-SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 843
Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
LQ ++ + + +++ E L + + + L + +Q R + LE E A+
Sbjct: 844 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS 903
Query: 1439 KMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
++A + +A + S E + ++ Q L R Q + V+ + LS + +
Sbjct: 904 RVAVVNQIARQLMHSGHPSE------KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSI 957
Query: 1499 -----------SWVAEHMP-HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLS 1546
SW+ E S L G +L RK ++ ++ A + ++ +
Sbjct: 958 QNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQK 1017
Query: 1547 SGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGW 1606
L + QAQ I+ + E+ W E++ + R L +A QQ+ D+ + + W
Sbjct: 1018 EAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSW 1077
Query: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
+ + ++S D +L+ +H+ ++ E+ Y +++ + +T + Q
Sbjct: 1078 LSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQY 1137
Query: 1667 RVVQERLR---EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
+++RL+ L ++ R L + +FLR+ + + +L +Q+ E
Sbjct: 1138 MFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE- 1196
Query: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
+ E A K F ++ +++ A L+ G+ ++++ +
Sbjct: 1197 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR 1256
Query: 1784 WSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSH 1843
+ E L+D + +D E+ + EK + + + L ++ H
Sbjct: 1257 HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKH 1316
Query: 1844 QGLERELVGTERQLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRA 1902
Q EL + L + +E G +Q + P+ A V+++ + + W VL+ + +
Sbjct: 1317 QAFMAELASNKEWLDK-IEKEG-MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374
Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
+L A F + D W + +Q ++ ++ +S + L Q L ++E R+K
Sbjct: 1375 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1434
Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE 2022
++ Q QAL G T EV + +Q + ++ + ++ L A ++ F R+
Sbjct: 1435 EIEE-LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1493
Query: 2023 CGRLEEIL-AAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-- 2078
+EIL + + L TS G +++ V+ LI+K++ K + + + ER +
Sbjct: 1494 VE--DEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551
Query: 2079 -----TLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
+L +R RL L Q + E E R L + + A +AE W+
Sbjct: 1552 VTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQ 1611
Query: 2134 AQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ 2193
+ D + + L KHQ E V+ + E + ++K AL+A SHP + +S
Sbjct: 1612 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISM 1671
Query: 2194 RLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
R + K + L+ R +L++R + + VD E WI E+EV +LGQD E
Sbjct: 1672 RQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYE 1731
Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
H L+ R REF ++ +G + +++ L+ +L N + I + + LN WA
Sbjct: 1732 HVTMLQERFREFARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWAD 1789
Query: 2314 FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
+ Q L + E+H + + RIQ+K + + G+D +V+ L R H
Sbjct: 1790 LLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTT 1848
Query: 2374 LEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
E ++ + QV L+ + RL + + A ++ R+ EV E+W L + RR L
Sbjct: 1849 FEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLV 1908
Query: 2433 ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSIS 2492
+ +M+++L++ + + Q++ PR ++ HQ KAE+D+ DS +
Sbjct: 1909 DTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFT 1968
Query: 2493 LARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK 2552
G+ LL H S +I++ L L ++ + W++ L+ LE+ F
Sbjct: 1969 TCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASV 2028
Query: 2553 MERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
E WL +E L+S + + +E L+ +H+ E + SALE
Sbjct: 2029 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALE 2077
Score = 301 bits (770), Expect = 1e-80
Identities = 366/1758 (20%), Positives = 702/1758 (39%), Gaps = 137/1758 (7%)
Query: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
R+ LEQ +R F R E WL E + V G DL + A +KH+A+E ++
Sbjct: 416 RQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA 473
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
++ +V R+L A R + V W+ L + R RL+ L + +
Sbjct: 474 YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKI 533
Query: 716 FADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRA 775
F + W+ E + + G+ E LL++H +E A++ E+ R
Sbjct: 534 FQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE-------ADIGIQAERVRG 586
Query: 776 ASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQT 835
+A A F + G+ +K DP I
Sbjct: 587 VNASAQKFATD-------------------------GEGYKPC---------DPQVIRDR 612
Query: 836 QDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLE 895
H+ Y+ L LA RRARLEE+ L+ F E + W+ ++ +L D
Sbjct: 613 VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 672
Query: 896 VMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL 953
VM+L K+ F ++ G + + E + S +I+ + + ++W LE L
Sbjct: 673 VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 732
Query: 954 KREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVL 1013
+ +L + + F + + D+L + + G E + + L +K V
Sbjct: 733 SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS--LVKKHKDVA 790
Query: 1014 ERRVHFLQSVVVKVEEPG-----YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQA 1068
E ++ ++ E+ +AES ++G++ ++ K+V E R + +T A
Sbjct: 791 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850
Query: 1069 RQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
E+ LW + + L + ++ + + + + L E++ R+ ++
Sbjct: 851 LYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQ 910
Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
++ + P +E+ L + + + L ++++ L L +Q + E
Sbjct: 911 IARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLE------- 963
Query: 1189 CANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
C ++W+ +LG D+ ++L ++ R L + + L+ EKL
Sbjct: 964 CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL- 1022
Query: 1241 QSQHP-AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
+S+HP A + +L I W ++ + R L + +LQ++ +D+ + W+ +
Sbjct: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082
Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQ-- 1356
+A+ + + L +HE ++E+ + ++ +G E++++ GQ D Q
Sbjct: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQ---GQTDAQYM 1138
Query: 1357 ---TRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
RLQ L + W L++ R + L Q+ +Q LR + A+ L E L +E
Sbjct: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
Query: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHL 1464
L ++ K+ + + K+ A+ ++ G S I E+ +H
Sbjct: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1258
Query: 1465 RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
+ E L ++L+ + +L +F W+ E M SY E N S
Sbjct: 1259 KNRETASELL----MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN-LHSKW 1313
Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIV-EQCQELEGHWAELERACEAR 1583
KH+ E+ +++ + ++ G L S P+ + +V E+ L W LE + +
Sbjct: 1314 LKHQAFMAELASNKEWLDKIEKEGMQL-ISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1372
Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
AQ L A + + ++L+ W+ + S DYG+D + L+ K Q L+ ++ +
Sbjct: 1373 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1432
Query: 1644 WSSMEELDQTAQTL-----TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
+EEL AQ L + EV ++ VQ + E L L E R L + +H
Sbjct: 1433 KKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNE----RKHNLLASKEIH 1488
Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
+F R+ ED W+ + A + G + + L K Q +++ R+
Sbjct: 1489 QFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547
Query: 1759 AESLLERGHS-AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
+++++ S + +RQR DL+ W L E T+ R L + + + D E
Sbjct: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAW 1607
Query: 1818 VQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQA 1876
+ E+ + A+D + L+ HQ LE+ + + +L +T+ R P++
Sbjct: 1608 MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS-RALVADSHPES 1666
Query: 1877 HAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEES 1936
+ RQ V + +A L+ E+RR +L+ L + V D W A
Sbjct: 1667 ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA----------- 1715
Query: 1937 SQEPSSGPLKLSAHQWLRAELEAREKLWQQAT-QLGQQALLAAGTPTKEV----QEELRA 1991
+E +G +L L+ R + + + T +GQ+ + E+ +
Sbjct: 1716 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAAT 1775
Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRL----EEILAAQEVSLK--TSALGSS 2045
+ + +D + + WA E + Q E + +EI + K LG
Sbjct: 1776 IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRD 1835
Query: 2046 VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKE---- 2101
VE L R H F + A + L+E L+ D+ + +R V E
Sbjct: 1836 QNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKS 1895
Query: 2102 ---LAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
ESR L + F W++ +Q++ P D+ + HQ
Sbjct: 1896 LLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQG 1955
Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
+AE+ A + T+ + G++LLA+ H + E+ ++L L + +++ R + L
Sbjct: 1956 IKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRL 2015
Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
+F + +AEAW+ +E ++ ++GQ ++ +L +R F ++A +
Sbjct: 2016 ILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSA 2075
Query: 2279 IRSISDLSLQLKNRDPEE 2296
+ ++ L L R EE
Sbjct: 2076 LERLTTLELLEVRRQQEE 2093
Score = 168 bits (425), Expect = 1e-40
Identities = 193/930 (20%), Positives = 370/930 (39%), Gaps = 104/930 (11%)
Query: 480 WQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
W+ L Q + +++ D Q L L+ +S G+ L V LL++
Sbjct: 1362 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1421
Query: 540 HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
+LE Q+ + L Q L S G S + + +K T+ L+ + R+
Sbjct: 1422 QQMLENQMEVRKKEIEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHN 1480
Query: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
L + + +F R+ E+E W+ E + G +L + ++K++ L+ E+ HQ
Sbjct: 1481 LLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPR 1540
Query: 660 CVDLVRRGRDLSARRPPTQPDP-GERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
D+ R +++ + +R ++ W LL R RL+ A QY+ D
Sbjct: 1541 IDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFD 1600
Query: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
AAEA +W+ E+ + +D+ +A ++L++H LE+ + +A + +L + RA A
Sbjct: 1601 AAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVA 1660
Query: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
+ HP + I Q
Sbjct: 1661 DS---------------------------HP------------------ESERISMRQSK 1675
Query: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQPQADTLEV 896
+ + Y L+ LA+ RR +L+E LF +L+ W+ ++ V+ + + + +
Sbjct: 1676 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM 1735
Query: 897 MQLKYENFLTALA-VGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKR 955
+Q ++ F +G+ V+ A++L ++ I ++ L++ W L L
Sbjct: 1736 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1795
Query: 956 EKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLER 1015
+ LA S E+ F + +++D +L + G ++T LQ + E
Sbjct: 1796 TRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQ---RMHTTFEH 1851
Query: 1016 RVHFLQSVVVKVEEPG------YA--ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
+ L + V +++E YA ++ +Q + + K + + R R +T
Sbjct: 1852 DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG 1911
Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLD 1127
+ F + L+LW E V Q+ ++E DV+S + L+ HQ + EI +
Sbjct: 1912 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI 1971
Query: 1128 AQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA 1187
+ + A S+E+ L L ++ +E+ WE R +WL+ LE+ +F R+ A
Sbjct: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031
Query: 1188 TCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAA 1247
+ +L +G+ V E L+++H F + +T R AL
Sbjct: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL--------------- 2076
Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS 1307
E+L +++ R Q E+R+R+ + + ++ QW KG +
Sbjct: 2077 ----ERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGL 2132
Query: 1308 GARRNILQ--------------TLKRHEAAESELL----ATRRHVEALQQVGRELLSRRP 1349
A + + T +R + ES + + R+ AL L R
Sbjct: 2133 PAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPART 2192
Query: 1350 CGQEDIQTRLQGL---RSKWEALNRKMTER 1376
QE +++G + +WEA N+K + R
Sbjct: 2193 --QETPSAQMEGFLNRKHEWEAHNKKASSR 2220
Score = 148 bits (374), Expect = 8e-35
Identities = 141/613 (23%), Positives = 263/613 (42%), Gaps = 26/613 (4%)
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
A+E ++ K+ A + + W+++ + + + + SL V+ Q Q N +
Sbjct: 297 AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQ-QLQAFNTYRTVEKPPK 355
Query: 2913 LT-----RVVLGTGYKLVQAGHFAAH---------EVAARVQQLEKAMAHLRAEAARRRL 2958
T V+L T ++A + + ++ ++LEKA H R A R L
Sbjct: 356 FTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA-EHERELALRNEL 414
Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
+ Q+ E A++F + +WL+E ++ ++ G A +A ++ EA + D+ A+
Sbjct: 415 IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAY 474
Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
R++ + A LE+ + ++ A+ V LL AR L+ L L ++
Sbjct: 475 EERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIF 534
Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE--VQSLGQAKVYALRKLA 3134
+E L + W+ SQDYG+ L GV+ L +K + +Q+ V A +
Sbjct: 535 QEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKF 594
Query: 3135 GTLERGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
T G P + R + +E ++ L Q R L + + F AE +G +
Sbjct: 595 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654
Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA-CRLGQLHPAAP- 3251
+EK ++ +D G L+SV L +HR E E+ + E + + H +
Sbjct: 655 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 714
Query: 3252 --GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAE 3309
+ ++E WA L+ + R + L +A+ H F ++ AW + ++ SS ++
Sbjct: 715 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH 774
Query: 3310 DVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQE 3369
D + L+ +H+++ +EI R L ++ L H S +V L +E R +E
Sbjct: 775 DEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKE 833
Query: 3370 LEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQD 3429
+ E LR Q ++ L K+ + E W+ E L + D+E++ HR +
Sbjct: 834 VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES 893
Query: 3430 LEKLLAAQEEKFA 3442
LE + Q + A
Sbjct: 894 LEPEMNNQASRVA 906
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 879 bits (2271), Expect = 0.0
Identities = 617/2173 (28%), Positives = 1045/2173 (48%), Gaps = 98/2173 (4%)
Query: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
+E I+ L +Q+KTFTKW+N+ + +I +LY +L DG L++LLE++SG
Sbjct: 40 FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97
Query: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
E LP P++G++R+H LEN +AL FL+ +V + +G +IVDG+ L+LGLIW IILRF
Sbjct: 98 EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157
Query: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
QI I + +E S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH
Sbjct: 158 QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214
Query: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
HRPDL+D+ L+ HNL AF VAE++LGI LLDPEDV PDE+SI+TYV +Y
Sbjct: 215 HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274
Query: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
HY S++ +R+ K++ ETE + +Y L +DLL WI + L +R F +SL
Sbjct: 275 HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334
Query: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
++Q L AF+ +RT EKPP+ Q++G E LLF +Q+ ++A N++ + PH+G ++++++
Sbjct: 335 TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394
Query: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
W LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q
Sbjct: 395 AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
LA VEAA ++ +E E R +AL ++A L +E YH + R++ + W L
Sbjct: 454 LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513
Query: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
+ LQ +R+++ A+ L Q++ + ++E++ S G+ L EV +LLQ+H L+
Sbjct: 514 QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573
Query: 544 EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600
EA ++ G V + T + G +V+Q + L Q + L + R+A L
Sbjct: 574 EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633
Query: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
EQ+ + +F +E E+W+KE Q + G+DL+ + +KHKA E E+ A
Sbjct: 634 EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693
Query: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
+ + + AR+ P R + V W L+ LQ A Q+ DA
Sbjct: 694 EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753
Query: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
+ +WL++ L GQD+ A L ++H L + LE+Q +
Sbjct: 754 DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
P+ D + L
Sbjct: 810 ------------------------------------------PEEFRDSPDVTHRLQALR 827
Query: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899
+ Y+ + A A LR+ RL+EA+ L+ +LW+ EK+ L + P DTLE +++
Sbjct: 828 ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885
Query: 900 KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
F K L + V+ +A L + S ++++ Q+ L+ RW + L E
Sbjct: 886 VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945
Query: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016
+ + ++ V ++ +C T + D +E+ + D + + Q+K LER
Sbjct: 946 RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003
Query: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069
V +Q+ V ++ E +S P Q GQ + L+ L + +Q+ + + E
Sbjct: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063
Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128
Q+FLQ+ W Q + S+++ + A++LL++H + +EI Q+ Q++ ++
Sbjct: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
+ + P+ + L L L +WE R L + L Q+F ++ A
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
Query: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
+N + L + + A + +++ +F + + + G KLV + +
Sbjct: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
++E++Q I+ + + ++++ L +L+LQ + Q+ EL W+ +K L +
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303
Query: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
RN+ +H+A +EL + +E + G++L+ +P + +L+ L W+
Sbjct: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363
Query: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
L E+ L A + L+ D + + +E L+S + G+DL S R+ + ++
Sbjct: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423
Query: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488
+E + ++ L + M + + + R L+LL+ L R QL++S
Sbjct: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481
Query: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
Q E WV E +P Y L Q +K++ LQ E+ H +V+ VL G
Sbjct: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
Query: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608
+ L + Q + E+ L+ W L A R Q L+ A QQY+LD E E W+
Sbjct: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
Query: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668
E+ V S + +DE + ++ +H Q + Y ++++L AQ L PE +++
Sbjct: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
Query: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726
+ Q ++ + L+++A R R+LE L + RE +DL+ W+ S+K+ +G+
Sbjct: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720
Query: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785
D +H L KF F + +G +RV E L++ GHS + + + L W+
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
Query: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845
+L EL R L + R E+L + EK LP +V D E+ R H
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840
Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
EREL Q+Q+ + A R+Q G +A A+Q ++Q V+ AW L RR QL
Sbjct: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900
Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965
RF + RD SW + + ++ +E ++ SS L + HQ + AE+E R K +
Sbjct: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
Query: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025
+LG+ L ++E++E+L+ + +R ++ + W + ERL+ + F R+
Sbjct: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
Query: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
E L AQE L + G +V+ VE+LI++HE F +K A+ ER L +P
Sbjct: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073
Query: 2086 RDRLPILLQRRMRVKELAESRG-------HALHASLLMASFTQAATQAEDWIQAWAQQLK 2138
+ L+ R + AE G A A + + T+ + E+ W Q L+
Sbjct: 2074 LE-----LKERQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPGEE-EGTWPQNLQ 2127
Query: 2139 EPVPPGDLRDKLK 2151
+P PPG +D K
Sbjct: 2128 QPPPPGQHKDGQK 2140
Score = 531 bits (1369), Expect = e-150
Identities = 483/1943 (24%), Positives = 842/1943 (43%), Gaps = 126/1943 (6%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW L E R ALR+ + ++ LE L + ++ ++
Sbjct: 391 DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
+N DL +EA + H+ +E + E +++ L + A ++K Q + R+
Sbjct: 447 QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505
Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
+ + W+ LQ ++ RR +LE L + + W ++ L E +
Sbjct: 506 ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565
Query: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002
L H+ + A++ + + T + G + +Q+ + L+ +++
Sbjct: 566 LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062
A ++ +L+ ++ F E E + +E + G + V L RKH+ F
Sbjct: 626 AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685
Query: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
L D +EA K P++ R+ + + ++K+LA L +
Sbjct: 686 LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745
Query: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175
F A + W+Q A +L G + L KH+ F E++ VM + +
Sbjct: 746 FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
+ + + + +V+ RLQ LR+ ++ + LR Q L++ + D E W
Sbjct: 805 QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863
Query: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
+ EKE +M + D +DLE +Q R + + + + + + S ++ +
Sbjct: 864 MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
EVK Q + LN RW +F + ++ ++ AL +H + + +K I +K ++
Sbjct: 921 RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977
Query: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
++ D G+DL + + RK LER+V IQA+V++LERE +L PE + RQ+
Sbjct: 978 ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037
Query: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465
+ E W L+ Q + D L + +LQA LQ+L L Q+ A D P
Sbjct: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091
Query: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524
S EA ++L++H K E+D DS + +G++++ P + Q L GL+ +
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
Query: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584
+L W+ L Q L Q F ++ E L ++E +LA D L E + K +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
Query: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644
+E K+ + + L G+ + + Q + R +A L
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
Query: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704
+ +LQ FLQ+ QE+ W+ +K L + + + L + K Q F AEL + +
Sbjct: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331
Query: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764
+ EG++L+ + + ++LE L LW ELQ +++K L A + ++ +L
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391
Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
W+ +E +LR+ G+ L V +L + +E V+ + + L Q + EG
Sbjct: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451
Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884
+E+ RF L EPL R+ LE+ L+ RD ++E WV+E+LPLA +
Sbjct: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
Query: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
DYG +L V+ +++Q L++E+ H VL G +LV+A ++ R+ L+
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004
+ LR AA R L+ A EAQQ+ + EA +W+ E+ + S+++ E +L+
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624
Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
R +R +E + I++L A L S +PE +++ V + +A L AE R
Sbjct: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684
Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
L+ L QL+RET L+ W++ K A S + GQD + V +L +KF F +E ++GQ
Sbjct: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744
Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
+V + L I + + W L + I R + LAA++++H +
Sbjct: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243
AE+ G + EK + ED G S+ + + H EREL + +V + Q A RL
Sbjct: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863
Query: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299
G+ A +V AW L R L A F ++LL+W +
Sbjct: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359
++E DV+ E L+ H+ + EI + G+ L+ H S E+ E
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983
Query: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419
LQ++ R +E+ E W RW+R + + + AEAWL E L D+GH+V
Sbjct: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043
Query: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK---TEMEQELLLQ-------PQELKPGRAGSSL 3469
VE L+ RH+ EK A+ E+FA ++K E+++ + + PQE + AG +
Sbjct: 2044 VEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAP 2103
Query: 3470 TSF-----QWRPSGHQGL-----------------------------------------G 3483
S + P +G G
Sbjct: 2104 VSHHAATERTSPGEEEGTWPQNLQQPPPPGQHKDGQKSTGDERPTTEPLFKVLDTPLSEG 2163
Query: 3484 AQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGRQPSSSSWDSCRGNLQGSSLSLFLDERM 3543
+ A P+D + MEG L K L ++ S+ SW++ L+ S L+ + D +
Sbjct: 2164 DEPATLPAPRDHGQSVQMEGYLGRKHDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKN 2223
Query: 3544 AAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGAEILFAAPSEEQAESWWRAL 3601
A + L L A CE +KH F LRL++G+E LF EE+ SW + +
Sbjct: 2224 LALGMPYHGEEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGV 2283
Query: 3602 GSTAAQSLSPKLKAK--PVSSLN 3622
+ +S S ++KA+ P+ SL+
Sbjct: 2284 STAINESQSIRVKAQSLPLPSLS 2306
Score = 399 bits (1026), Expect = e-110
Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)
Query: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
H KLV + A ++ E A++ R L R+E R++ L L + + + A
Sbjct: 384 HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436
Query: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
W+ E + A + G ++ K+ HEA E++ A V AL+ + +EL Q
Sbjct: 437 WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496
Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
+ I R + W L + R L+ ++L + + + + +++++ L S+E
Sbjct: 497 KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556
Query: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465
G+ L + L ++H+ +E++ K+ A+ + P ++++ HL
Sbjct: 557 GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
Query: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
+ E L A R QL+ S L +F + SW+ E S Y + L L
Sbjct: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581
RKHK + E++ ++++ + A GHPQ I + +E+ W +L+
Sbjct: 677 RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733
Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
+ LQ A F Q+ D +L+ W+++ L+S D G+DE AT L KH+ EEL
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694
ME L+Q AQ PE+ R + + +L+AL+EL A R + L+
Sbjct: 794 ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847
Query: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
L L+ E + + W+ +++ A ED E H +F +++ ++
Sbjct: 848 LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904
Query: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809
L A SL+E GH V+Q Q L T W L R A+ ++ LRVH
Sbjct: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961
Query: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
D E + +K + + ++ RDL G+ A R GLER++ + ++ L + ++
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927
P Q + QRQ+ + + W LQ+ ++ + L L F + D+ +W +
Sbjct: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986
++ + E+ + L H ++ E++ + +Q+ + G++ + P +
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
+ L L + + + W + L Q F ++ + E IL+ QE +L S+
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098
E E IRK E FL KVL+ D + E L ++++++ ++ R +
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258
Query: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
E A+ L +L + +F Q + WI + V + R+ LKHQA
Sbjct: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317
Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
F AE+ +HE + ++ +G+ L+ + VSQ+L+ L + W++L+ + Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377
Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276
R+ LQ WI E ++ D G+DL ++ +L+ E + N + +G+
Sbjct: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437
Query: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
A + S+ D L ++ R + ++ + +R+ QL + A
Sbjct: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482
Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
+SR+L++ T ++E+ L Q+ D G +L++VQ ++K++ L+ E+ +VE + +
Sbjct: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
Query: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448
+L + + L R + SW +LR A R + L ++AQ+ L A E
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599
Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508
+ Q L D P+ A ML+ H + ++ + +I S Q LL+AGHP
Sbjct: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657
Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
I ++ +++ + L+ +E + +L+ L + +E+W+ KE +S
Sbjct: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625
+ + L + K ++ E A ++ + A L GH EA + +
Sbjct: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
Query: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
L TR L L + E+ + EK+ E+ LD + +
Sbjct: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
Query: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744
+ F+ EL Q Q+ Q RL +EAIQ + +E+ A W L D +
Sbjct: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804
+L + R +L +W+E I ++ + + V L+ + + A ++ +
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
Query: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864
++ A L ++ ++ H ++++ E+ ++++ R K + E + R L + +F
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
Query: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
RDA AW+ + P A+ D+G ++ +V L ++H+ E +S
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
Score = 324 bits (831), Expect = 9e-88
Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)
Query: 872 ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927
+L W+E QT+ + + A++L +Q + + F T V K + + E L +
Sbjct: 313 DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371
Query: 928 RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979
R N+ ++ + ++++ W LE + + + L + + E L +
Sbjct: 372 RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431
Query: 980 QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029
+R+ L Q Q D A++ A+KK T E RV L+ + ++E+
Sbjct: 432 AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
Query: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089
Y + + + + + + L +QE + R +R T A Q Q+ + W + ++A
Sbjct: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
Query: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146
L S E + + LL++H+ + +I + ++++ + A + D Q + +
Sbjct: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
Query: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206
+ L Q +EL + R+ L++ L KF E+D + + + G+D+
Sbjct: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
L L ++H+ F L L E + +V + + +++ + AQW +L+
Sbjct: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
Query: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325
+ ++ L + +++ D +L W+++ + + E G + L K+H+
Sbjct: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
EL +R +E L+Q + D+ RLQ LR ++ + + R LQ+A
Sbjct: 791 ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
+ + + + + E L E L + +Q R L+ E +TL ++ +
Sbjct: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
Query: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
A+ + S +++ Q HL R + Q ++ R + +++ +H +C W
Sbjct: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
Query: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
+ + T L G ++ RK L+ +V A Q +V + + L S Q
Sbjct: 970 ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029
Query: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
+ I ++ + LE W L+++ + + L + Q + D+ + + W+ + V+S D
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676
+L+ +H +++E+ + S + + ++ + + G PE + Q E L
Sbjct: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149
Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
AL + +R L L EF ++A+ + L++Q+ E + E A
Sbjct: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
KF F +E +V + L+ G+ ++++ Q ++ + E Q
Sbjct: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856
LRD ++ E+ + +K + + + L + HQ EL E
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
Query: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
L E ++ G+ Q + PQ A V Q+ +A+ + W LQ +++ L AR
Sbjct: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386
Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971
D W + + L+ ++ ++ +S L+ + + ++ R+ +L+ Q +G
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446
Query: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
++ A + K + L L ++ Q+ + A+ Q E E +
Sbjct: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494
Query: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085
+ + L SA G++++ V+ ++K++ ++L + E L+ + + +
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554
Query: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
+RL L R++E A R L + + A +AE WI + P
Sbjct: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614
Query: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203
D + L +H + V+ + + +A + + LL+ HP GE RLQG + KH+
Sbjct: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673
Query: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263
L+ R ++LE+ + + + D E WI EKE+ + ++GQD +H LR + R
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
Query: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323
+F + +G + +++ +L + E I + + LN WA + Q
Sbjct: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
Query: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383
L + ++H + I EK + D G D + + R H ERE+H +
Sbjct: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850
Query: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
QV+ + RL + E A +++++QEV+ +W L RR L + +
Sbjct: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
M ++LL + + Q++T PR +++ HQ AE+++ + + S G+ LL
Sbjct: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
H S +IR+ L + + W+ +L+ LE+ F E WL ++E
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030
Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
LAS + +E L+ +H+ E A + +ALE
Sbjct: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 299 bits (765), Expect = 4e-80
Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)
Query: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417
WE+L R+ +EL + + EQL R+ L + + + G DL
Sbjct: 396 WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455
Query: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472
+ + +K+H+ +E+++ ++ AL +A + I LR LQ
Sbjct: 456 AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515
Query: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532
L R +L+ ++ L + + W+ E H + + L + L +KHK ++
Sbjct: 516 LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575
Query: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589
++ +V+ + ++ Q Q I ++ LE + EL R L+Q
Sbjct: 576 DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
Query: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
+ ++F ++ E E W++EK + SS DYG+D + L L KH+A ++EL + +E+
Sbjct: 636 SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
Query: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706
+ Q A + + ++ + R++E Q L++LAA + L+ +F +A+D
Sbjct: 696 IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754
Query: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766
L+ WL + G E +G+D L K F ++E + A+ E
Sbjct: 755 LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813
Query: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826
+ P V R Q L+ + ++ R L++ V + + EK L
Sbjct: 814 RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872
Query: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
D L LE L++E+ Q+ + A + + P++ V+Q Q
Sbjct: 873 EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931
Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
+ W Q + +RR ++ A + + + + W + ++ + +G +
Sbjct: 932 LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
Query: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001
KLS + A ++AR ++ +Q Q + + +++ + + L++ + Q
Sbjct: 992 AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
Query: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061
+ +++ L Q Q FL++ + L+ + ++ + + S+ E EQL+++H
Sbjct: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
Query: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113
+ ++E + + + + D +LL +R+ + + ESR H L
Sbjct: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
Query: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173
L F + A QAE + L PP L + K + F ++ + + + S
Sbjct: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229
G L+A+ + + ++ +++Q + RK+ E ++A L LE +NFL+ Q +
Sbjct: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286
Query: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289
L WI +K + D+ D L + + + A + + +I QL
Sbjct: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339
Query: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349
+ P+ ++ Q+ L+ W Q L A + + ++ K I E
Sbjct: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399
Query: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409
+++ D GKDL SV R+L K + +E +V+ + ++ L +V + + +A + R
Sbjct: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459
Query: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469
++ E + + + + R L + ++E L AQ A T+
Sbjct: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512
Query: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529
+ ++++Q + E+ T + GQQL+ A D+ + L L+ L A
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
Query: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
+L+ A E Q + ++ E W+ +E + S+ + +L +H +
Sbjct: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632
Query: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648
+E I L + A+GL GHPE + + R Q + + A + A R+ +LE +
Sbjct: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691
Query: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706
L +++ ++ W+ EK LVA + D + K ++F E A + +
Sbjct: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
Query: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766
+RL+ GH + I E + L +W +L + ++ L + + R + E+
Sbjct: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811
Query: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814
++ P +V L A T V A LLG Q ++ D R A G+
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869
Query: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874
A+ ++ + + + +++L + RRT L + +FF A + ++W+
Sbjct: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919
Query: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934
+ + Q+ + +S+V L + HQ + +E+ + L G L+Q H A+ E
Sbjct: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979
Query: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994
+ ++QQ+ + + R L+ E QF + A +WL + L S D GH
Sbjct: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
Query: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053
+ ++ + L++R EA ++ +++ R L++ L L+ R+ E P A+ +E
Sbjct: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096
Query: 3054 ELLRRAEARGHGLQEQ 3069
E A H E+
Sbjct: 2097 ETAGEAPVSHHAATER 2112
Score = 165 bits (417), Expect = 9e-40
Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)
Query: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778
+ ++ W L++ ++ L Q+ E L R R E WL + +
Sbjct: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
G L V +E + AL AQ +E + + + + +L+
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ L+E LQ RR LE L K F+D + W+ E + ++G+ L V L +
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955
+H+ +E++++ + + K + + + + R+ LE+ L AA
Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
R+ L+Q++ +F E+ EA SW+ E+ + S D G + L R+ +A + +L
Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
+E++ Q A + +RK P++ A+++ V +L A LQ+ Q
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
+ + L AWL +D GQD + L +K F +E++ + ++ G
Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
Query: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
E R +P +QA R + + D R + L A ++++ + M
Sbjct: 809 FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864
Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253
EK + + +L + +Q + L++E++ + ++ + A L +
Sbjct: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
Query: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308
+ + Q+ W Q ER + + A + H + C+E W ++ ++ S+++L
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368
D+AG + + L +++ + + L +E QQL+D+ ++ + + LE Q
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
Query: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428
L+++ + E LQ Q L+ +AWL+ + + D S+ + E LL +H
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
Query: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481
++ + ++ + +++++ + + E LL Q L+ G + W H
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163
Query: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513
L L +DAK + + E+ HL P
Sbjct: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196
Score = 143 bits (361), Expect = 3e-33
Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909
A+E ++ K+ A + + W+++ + + ++ + SL+ V + LQ ++ +E
Sbjct: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
Query: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960
E V+L T ++A + + H+ V + +A A R E A R L+
Sbjct: 357 QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+Q Q A++F + +WL+E ++ ++ G+ A +A ++ EA + D A+
Sbjct: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077
R+ L+ A LE + ++ A+ + + L ++R L+ L L +L +
Sbjct: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
Query: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136
+ L W+ A S ++G+ L V+ L +K ++ G + K L T
Sbjct: 536 DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595
Query: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
+G P IQ + S +E +E L R L + + F E + ++E
Sbjct: 596 EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655
Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251
K + D G L+SV LQ++H+ E EL ++ + ++ EA R HP
Sbjct: 656 KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715
Query: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
+ +V W L+ A + L A F G +L AW Q+ L S E++ +D
Sbjct: 716 ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775
Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
L +H++ +E+ E R + L Q+ Q + S +VT LQ L Q++
Sbjct: 776 GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834
Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
LR QR E+ L + + E W+ E L + + ++ D+E++ HR L+
Sbjct: 835 AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894
Query: 3432 K 3432
+
Sbjct: 895 Q 895
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 872 bits (2254), Expect = 0.0
Identities = 664/2274 (29%), Positives = 1070/2274 (47%), Gaps = 109/2274 (4%)
Query: 3 SQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELI 62
S +E I+ L +Q+KTFTKW+N+ + G I +LY +L DG L RLLE++
Sbjct: 45 SLFECSRIKALADEREAVQKKTFTKWVNS--HLARVGCHIGDLYVDLRDGFVLTRLLEVL 102
Query: 63 SGEALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIIL 121
SGE LP P+RGR+R+H LEN +AL FL+ +V + +G +IVDG+ L LGL+W IIL
Sbjct: 103 SGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIIL 162
Query: 122 RFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALI 181
RFQI I ++ E+ + S K+ALL+WCQ KTA Y VNI +F+ SW DGL FNALI
Sbjct: 163 RFQIQVIKIETED---NRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALI 219
Query: 182 HAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSL 241
H HRPDL+D+ L +NL AF AEQ LG+A+LLDPEDV PDE+SI+TYV
Sbjct: 220 HRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVS 279
Query: 242 YYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPD 301
+YHY S++ +R+ K+L Q+ E + +YE+L A+LL WI + + F +
Sbjct: 280 FYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFAN 339
Query: 302 SLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
SL ++Q L AFT + T EKP + Q++G E LLF +Q+ L+A NRR F+P EG G+ ++
Sbjct: 340 SLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDI 399
Query: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
+ W LE AE R AL+ L++ ++LE LA+RF HK A+RES+L + ++++ Q
Sbjct: 400 DKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-G 458
Query: 422 ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQ 481
L VEAA+++ +EA I E R Q +AE+A L E Y+ VA +++ V +W
Sbjct: 459 YELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWA 518
Query: 482 RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
L + +R ++ A+ + QE+ +EE+Q S CGQ L E +LLQ+H
Sbjct: 519 LLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHG 578
Query: 542 LLEAQVSAHGAHVSHL---AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
LLE ++A V L A + ++L +V+ + + L RRA
Sbjct: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRA 638
Query: 599 LLEQTLQRAEFLRNCEEEEAWLKE---------------CGQRVGNAALGRDLSQIAGAL 643
LE + L+ EE E+W ++ G A DLS A L
Sbjct: 639 ELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLL 698
Query: 644 QKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDP--------GERAEAVQGGWQLL 695
+HK L+ E+ +A+ +R G +L A P ERA + + WQ L
Sbjct: 699 AQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRL 758
Query: 696 QTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRL 755
+ R RLQ A + Q+ AD WLR+ G D+A++ L R+H
Sbjct: 759 EEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQH--- 815
Query: 756 ERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAW 815
RA E+ +G + R L T+ A GP A
Sbjct: 816 ----RALTGEVE--AHRGPVSGLRRQLATLGGA--------SGAGPLVVA---------- 851
Query: 816 KMALPAEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQ 874
LQ + Q + + +A LRR L +A+A++ +
Sbjct: 852 -----------------LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACE 894
Query: 875 LWL--EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGN 932
LW+ ++Q +L RV D +EV+Q ++E+ + G +V+ + ++L + +
Sbjct: 895 LWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPS 954
Query: 933 STQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQ 992
S +++ Q+ L+ RW ++ L ++ +++ + V + + E + Q+R+ +E+
Sbjct: 955 SDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVES-A 1013
Query: 993 PGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQV 1052
P + L + LE R L + E A++ L E L +
Sbjct: 1014 PRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGAL 1073
Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE--VSVDVASAQRLLREHQ 1110
A Q FL + L W Q E + + A LL H
Sbjct: 1074 ASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHA 1133
Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPD---SQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
L EE+ +E ++ A S+ + A D + + L L +L LWE R++
Sbjct: 1134 ALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARRE 1193
Query: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
L + Q F R++ N + L L V L+QHR+F +
Sbjct: 1194 ALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQ 1253
Query: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
+ + E L++ + +E + + + Q R++Q ++L L+LQ + +D
Sbjct: 1254 KMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRD 1313
Query: 1288 VAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSR 1347
EL W+ EK LMA + + RH+A +EL + +E +++ G++L+
Sbjct: 1314 CHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE 1373
Query: 1348 RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGAL 1407
+P ++ +L +R W L + +L +A + +QL++ + ++L +E L
Sbjct: 1374 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQL 1433
Query: 1408 QSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA---ILEETQKHL 1464
Q + G DL + K+ Q +ES+ ++ L + + PA ++ E Q +
Sbjct: 1434 QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV 1493
Query: 1465 -RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
RL L L R L AS ELHQ H + EL+WV E +P T L Q
Sbjct: 1494 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 1553
Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
+K++ L+ E++AH +++ VL +LA+ P+A+ + ++L+ WA L A E R
Sbjct: 1554 IKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERR 1613
Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
Q L A +QY+ DV+E+E W+ E+ L+ S D G+DE +TL+L+ KH L++ + Y
Sbjct: 1614 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 1673
Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFL 1701
S+ +L + + L P+ +++ Q ++ AL+EL R LE L++
Sbjct: 1674 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLS 1733
Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM-GSQRVAACRLLAE 1760
R+ +L+ W+A +K+ G LG+D EH L KF++F + M G +R+AA + +
Sbjct: 1734 RQVSELEHWIA-EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 1792
Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
L+E GH+A + + + L AW+EL EL R L + + D E+ Q++E
Sbjct: 1793 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 1852
Query: 1821 KATSLP--NNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA 1878
K LP + R+ + E +L Q+++L E A +++ + G A A
Sbjct: 1853 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 1912
Query: 1879 VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQ 1938
+ R+Q V Q W L E R + RF + VRD SW + + + +
Sbjct: 1913 IASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR 1972
Query: 1939 EPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQ 1998
+ SS + ++ HQ L+ ELEAR +LG+ LL E+Q +L L ++++
Sbjct: 1973 DVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEE 2032
Query: 1999 VYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEV 2058
V + W R E LQ + F +E + L AQE L++ LGSSV+EVEQLIR+HE
Sbjct: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEA 2092
Query: 2059 FLKVLTAQDKKEAALRERLKTLRRPRV-RDRLP--ILLQRRM--RVKELAESRGHALHAS 2113
F K A +++ ++LR RL T+ + + + + P LL R+ ELA L
Sbjct: 2093 FRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPG 2151
Query: 2114 LLMASFTQAATQAEDWIQAWAQ----QLKEPVPPGDLR---DKLKPLLKHQAFEAEVQAH 2166
A +A D + A + +++ + P L+ D+L + A A
Sbjct: 2152 GYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211
Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
E+ + A A + P E + R + L + RQ + +E RR
Sbjct: 2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRR 2265
Score = 441 bits (1135), Expect = e-123
Identities = 439/1763 (24%), Positives = 762/1763 (43%), Gaps = 114/1763 (6%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW EL + R ALR + ++ LE+L Q + ++
Sbjct: 398 DIDKAWGELEKAEHEREAALRAE----LIRQEKLELLAQRFDHKVAMRESWLNENQRLVS 453
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGP--QAHAVQQRQ 1883
+N +L +EA ++ H+ +E ++ E ++Q + E A Q L V ++
Sbjct: 454 QDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELA---QALAAEGYYDIRRVAAQR 510
Query: 1884 QAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSG 1943
+V + WA+L + RR +LE+ L + + W ++ L E Q
Sbjct: 511 DSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEA 570
Query: 1944 PLKLSAHQWLRAELEAR----EKLWQQATQLGQQALLAAGTPT-------------KEVQ 1986
L H L ++ A+ E L A + Q P E+Q
Sbjct: 571 DDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQ 630
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS- 2045
E+ + + + WA QE +AE + R+ RL E + A G++
Sbjct: 631 EQAARRRAELEASRSLWALLQELEEAES----WARDKERLLEAAGGGGAAGAAGAAGTAG 686
Query: 2046 ----VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-----------------TLRRPR 2084
+ +L+ +H++ L + A L++ L+ T+
Sbjct: 687 GAHDLSSTARLLAQHKILQGELGG---RRALLQQALRCGEELVAAGGAVGPGADTVHLVG 743
Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
+ +R +R R++E A R L + + F DW++ A +L G
Sbjct: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRD-AYRLAAAGDFG 802
Query: 2145 -DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKH 2201
D + +H+A EV+AH ++ + ++ L S P + R+ +
Sbjct: 803 HDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQL 862
Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKE---VKMNVGDLGQDLEHCLQL 2258
+ ++ + ALR Q L D V E WI EKE + M V D D+E +Q
Sbjct: 863 FAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVE-VVQH 921
Query: 2259 RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNL 2318
R + NS V D ++ +L ++ + +EV+ CQ LN+RW +
Sbjct: 922 RFESLDQEMNSLMGRVLDVN-HTVQEL-VEGGHPSSDEVRS-CQ--DHLNSRWNRIVELV 976
Query: 2319 LRYQQQLEGAL--EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
+ ++++ L E HVL E+ V +++EK +++ + L + LE
Sbjct: 977 EQRKEEMSAVLLVENHVL--EVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEA 1029
Query: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436
+ ++ + +L E L +R P A L +E+ W L S AQ EA+ A
Sbjct: 1030 ALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAA--- 1086
Query: 2437 AQKLQAMLQEL------LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
A +LQ L +L LV AQ + P P S EA +L H K E+D +
Sbjct: 1087 AGRLQRFLHDLDAFLDWLVRAQEAAGGSE-GPLPNSLEEADALLARHAALKEEVDQREED 1145
Query: 2491 ISLARSTGQQLLTA-----GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQL 2545
+ + + LL A G + D + L LE L G W+ + L QA QL
Sbjct: 1146 YARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHIYQL 1203
Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATAR 2605
FL + + L ++E +L+ L + +E L +H+ +E+ K+ A
Sbjct: 1204 FLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAE 1263
Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE 2665
GL + G+ + A +L + + +A +L + +LQ FL+D E+ W+ E
Sbjct: 1264 GLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE 1323
Query: 2666 KNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQE 2725
K L+A + D L + + Q F AEL + ++++REGQ+L+Q + ++++
Sbjct: 1324 KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK 1383
Query: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALP 2785
+L E+ W EL+ +Q K +L +A +A +L +S EL+ L +E +L+ G L
Sbjct: 1384 KLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA 1443
Query: 2786 GVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE 2845
V L + +E+ V++ R+ L Q A E + V E+ + +R L E
Sbjct: 1444 TVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLE 1502
Query: 2846 PLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLES 2905
PLQERR L A L + D D+E+AWVQE+LPLA + G L AV+ +++Q L
Sbjct: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
Query: 2906 EMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQE 2965
E+ +H VL L A V ++QL+ A A LR A RR+ +L A +
Sbjct: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622
Query: 2966 AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQ 3025
+Q+ ++ E +WL E+ ++ SED G ++T LL++ ++ +E + I +L +
Sbjct: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682
Query: 3026 TAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAW 3085
L +P+S ++ + V + L E R L++Q L+QL R+ L+ W
Sbjct: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 1742
Query: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
+ K A S + GQD E V VL+EKF F E G+ ++ A+ ++ L
Sbjct: 1743 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
Query: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGED 3204
+ + + AW L + + R + LAA+ E+H F A ELQG+++EK L +
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 1862
Query: 3205 GGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQE 3259
S ++Q+ R E +L+ + +V +LQ A +L G+ A +V +
Sbjct: 1863 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ 1922
Query: 3260 AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLG 3319
W L + ++ ++ A F + ++LL+W + + DV+ E L+
Sbjct: 1923 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMN 1982
Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQ 3379
H+ L E+ + ++ G+ L+ N M+ E+ L +L R +E+ E W W+
Sbjct: 1983 YHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWE 2042
Query: 3380 RCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEE 3439
+ + + Q A+AWL E LL + G SV +VE L+ RH+ K AA EE
Sbjct: 2043 WLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEE 2102
Query: 3440 KFAQMQKTEMEQELLLQPQELKP 3462
+F+ +++ +++ + + P
Sbjct: 2103 RFSSLRRLTTIEKIKAEQSKQPP 2125
Score = 355 bits (910), Expect = 6e-97
Identities = 407/1881 (21%), Positives = 778/1881 (41%), Gaps = 124/1881 (6%)
Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQE--------WKQDVAELMQWMEEKGLMAAHEPSG 1308
I W L+ +R L A L QE + VA W+ E + + + G
Sbjct: 399 IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFG 458
Query: 1309 ARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
++ +K+HEA E+++ A V+ + ++ + L + + + + +W
Sbjct: 459 YELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWA 518
Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQ 1427
L + R L+Q +++ +++ + +E+++ L S E GQ L + L ++H
Sbjct: 519 LLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHG 578
Query: 1428 QLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLRR-LELLQGHLAIRGL 1479
LE + + ++ AL + A + P ++ H+ L LQ A R
Sbjct: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRA 638
Query: 1480 QLQASVELHQFCHLSNMELSW------VAEHMPHGSPTSYTECLNGAQSLH--------- 1524
+L+AS L SW + E G A H
Sbjct: 639 ELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLL 698
Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAASG---HPQAQ--HIV---EQCQELEGHWAEL 1576
+HK LQ E+ + +Q+ L G L A+G P A H+V E+ W L
Sbjct: 699 AQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRL 758
Query: 1577 ERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQAL 1636
E A R + LQ+A Q+ D+ L W+ + L ++ D+G DEA++ RL +H+AL
Sbjct: 759 EEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRAL 818
Query: 1637 QEELAIYWSSMEELDQTAQTLTGPE------VPEQQRVVQERLREQLRA-LQELAATRDR 1689
E+ + + L + TL G V Q RVV+ EQL A + E+AA R +
Sbjct: 819 TGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVE---AEQLFAEVTEVAALRRQ 875
Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQ---AAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
L L ++ E + W+ ++Q + + +SL +D E H +F ++
Sbjct: 876 WLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSL-DDVEVVQH---RFESLDQEMN 931
Query: 1747 MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLR 1806
RV + L+E GH + VR Q L + W+ + EL + R +
Sbjct: 932 SLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVEN 991
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
++ EV QV+EK ++ + R L+ +L GLE L E + LLE A
Sbjct: 992 HVLEVAEVRAQVREKRRAV-ESAPRAGGALQWRL---SGLEAALQALEPRQAALLEEAAL 1047
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ + P QA + Q + + W L + + A L RF + + W R
Sbjct: 1048 LAERFPA-QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106
Query: 1927 VRQDLQVEESSQEPSSGPLK-----LSAHQWLRAELEAREKLWQQATQLGQQALLAAGT- 1980
+ + S+ P L+ L+ H L+ E++ RE+ + + + L A G
Sbjct: 1107 AQ---EAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163
Query: 1981 --PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK 2038
P + E L L+ ++ W ++E L QLFLR+ + +L QE++L
Sbjct: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALS 1223
Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVL-TAQDKKEAALRERLKTLRRPRV-----RDRLPIL 2092
+ L +VE VE+ +++H FL + +Q K + A++ LR+ + ++ + L
Sbjct: 1224 GAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
Query: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKP 2152
L++ + A+ LH L + F + + + WI ++ D K
Sbjct: 1284 LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRE-DNHKLHKR 1342
Query: 2153 LLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
L+HQAF AE+ ++E + + ++G+ L+ + A V ++L +R+ W +L +
Sbjct: 1343 WLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAK 1402
Query: 2213 GQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGD 2272
++L + + +Q + + E ++ D G DL ++L+ +
Sbjct: 1403 ARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM------E 1456
Query: 2273 TVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
+ + R + +L Q +P +++ +R++ + R L ++ L + E
Sbjct: 1457 SQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKE 1516
Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
+H ++ +LD+ +QE+ L + G L++VQ+ ++K++ L RE+ ++E +
Sbjct: 1517 LHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLE 1576
Query: 2391 EVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449
G L RSPE A +R +++ +W LR A++R++ LDA Q ++ + E+
Sbjct: 1577 RAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEA 1635
Query: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFS 2509
M + + ++L++H + + ++++ +SI+ + LL GHP S
Sbjct: 1636 WLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS 1695
Query: 2510 SDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGL 2569
I + + +++ +L+ +E ++ L+Q L V ++E W+ KE S L
Sbjct: 1696 EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 1755
Query: 2570 WDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQAML 2626
+ L + K E+ E AG +++A+ L + GH A + +
Sbjct: 1756 GQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 1813
Query: 2627 LRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTAML 2681
L GTR L R+L F D++E+ + EK L E + +
Sbjct: 1814 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873
Query: 2682 PAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNS 2741
L+ ++ L + + Q QE + + + G H +EAI R +E+ W EL
Sbjct: 1874 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLSAC 1931
Query: 2742 QKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAV 2801
+ + +ALR + +L +W++ I ++ A + + V L+ + L+ +
Sbjct: 1932 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTEL 1991
Query: 2802 DKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLL 2861
+ + + ++ + +A +++ Q +L R + + E L+ +
Sbjct: 1992 EARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVH 2051
Query: 2862 KFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTG 2921
+F ++A AW+ + PL +++ G S+ V L +H+ ++ E
Sbjct: 2052 QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEE--------- 2102
Query: 2922 YKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLA 2981
F++ +++++ + R E LL G +
Sbjct: 2103 -------RFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGY-- 2153
Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDL--EAFSPRIERLQQTAALLESRKNPESP 3039
ERG L+ S + + R+ +++L E PRI+RL + +E P +P
Sbjct: 2154 ERG--LEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211
Query: 3040 KVLAQLQAVREAHAELLRRAE 3060
+ A+ A A ++ R E
Sbjct: 2212 EDAAETPATPAAAEQVRPRPE 2232
Score = 305 bits (780), Expect = 7e-82
Identities = 450/1974 (22%), Positives = 808/1974 (40%), Gaps = 154/1974 (7%)
Query: 1482 QASVEL--HQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQG 1539
Q +EL +F H M SW+ E+ S ++ L ++ +KH+ ++ ++ A++
Sbjct: 424 QEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEE 483
Query: 1540 QVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLD 1599
+VQ V ++LAA G+ + + Q + WA L AR L+Q + Q+ F +
Sbjct: 484 RVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQE 543
Query: 1600 VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA---QT 1656
+ + W+EE + + SR+ G+ L+ KH L+ ++A +E L+ A
Sbjct: 544 MVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQ 603
Query: 1657 LTGPEVPEQQRVVQERLREQ---LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLAS 1713
L G + P +V+ R+ L LQE AA R ELE + L L+E E+ + W
Sbjct: 604 LQGYQ-PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARD 662
Query: 1714 QK---QAAKGGESLG----EDPEHALHLCTKFAKF--QHQV---EMGSQRVAACRLL--A 1759
++ +AA GG + G H + A+ QH++ E+G +R + L
Sbjct: 663 KERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCG 722
Query: 1760 ESLLERGHSAGP--------MVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
E L+ G + GP + +R + W L E R L++ + DL
Sbjct: 723 EELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADL 782
Query: 1812 LEVLTQVQ-------------EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQ 1858
+L ++ ++A+S +AR L ++ +H+G + G RQL
Sbjct: 783 DGLLDWLRDAYRLAAAGDFGHDEASS--RRLARQHRALTGEVEAHRG---PVSGLRRQLA 837
Query: 1859 ELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVR 1918
L +G GP A+Q R Q +A + RR L A + R V
Sbjct: 838 TLGGASG------AGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVH 891
Query: 1919 DYASWAARVRQDLQVEESSQEPSS-GPLKLSAHQWLRAELEAREKLWQQA-TQLGQQALL 1976
W Q L S + P S +++ H++ + E + + Q L+
Sbjct: 892 ACELWIGEKEQWLL---SMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV 948
Query: 1977 AAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQ--LFLRECGRLEEILAAQE 2034
G P+ +E+R+ Q D + W R E ++ ++E + L E LE +
Sbjct: 949 EGGHPS---SDEVRSCQ---DHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQ 1002
Query: 2035 VSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDR 2088
V K A+ S+ L + L A + ++AAL E L + R+
Sbjct: 1003 VREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQG 1062
Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWI---QAWAQQLKEPVPPGD 2145
L + A++ G A+ A+ + F DW+ Q A + P+ P
Sbjct: 1063 AEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPL-PNS 1121
Query: 2146 LRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAG---EVSQRLQGLRKHW 2202
L + L +H A + EV EE + EALLA G + + L L W
Sbjct: 1122 LEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGW 1181
Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
L R + L + FL+ + A ++ +E+ ++ +L +E + ++
Sbjct: 1182 HKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQH 1241
Query: 2263 REFRGN-SAGDTVGDACIRSISDLSLQ--LKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
R+F +++ L Q + +E ++Q N A
Sbjct: 1242 RDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQ------ 1295
Query: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD-CGKDLESVQRLLRKHEELEREV 2378
++ Q+L LE+ R+ + I EK ++ A D +D + + +H+ E+
Sbjct: 1296 QWMQKLHDQLELQHFLRDCHELDGWIHEK--MLMARDGTREDNHKLHKRWLRHQAFMAEL 1353
Query: 2379 HPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQ 2438
+ +E +ERE +L Q PE A +R + E+ + W +L S Q + L +A
Sbjct: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKAD 1413
Query: 2439 KLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTG 2498
+L EL + +Q+ L++ Q +++++ W R G
Sbjct: 1414 QLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEW------YREVG 1467
Query: 2499 Q-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKM 2553
+ Q TA P ++++ + + L L QE + L + EL ++
Sbjct: 1468 ELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDE 1527
Query: 2554 ERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHP 2613
W+ + + L ++ + K++ L +++ ++ + A L P
Sbjct: 1528 LAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP 1587
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLREKNLVALE 2672
EA+ A+ R L A R+A RR + L+ Q++ + D EV AWL E+ L+ +
Sbjct: 1588 EAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS 1646
Query: 2673 EGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQRLLQGGHPASEAIQERLEEL 2730
E QL K ++ Q E +++ +L R+ + LL+ GHP SE I R ++
Sbjct: 1647 EDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 1705
Query: 2731 GALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGEL 2790
L+ L++ +++ L++ +L R + ELE+W+ EV +P +GQ V L
Sbjct: 1706 DRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 1765
Query: 2791 LGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQE 2849
E + R+ A + Q + GH A + E L + + L E +
Sbjct: 1766 QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGT 1825
Query: 2850 RRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQDYGQSLSAV-RHLQEQHQNLE 2904
R L A L KFF DA E ++EK LP L + S S++ R L+ +L+
Sbjct: 1826 RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQ 1885
Query: 2905 SEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQ 2964
+S L + V AG A +A+R Q++ + L + RL +
Sbjct: 1886 LLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQGWKELLSACEDARLHVSSTA 1942
Query: 2965 EAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQ 3024
+A +F +++ + SW+ + + D + + L+ + K +LEA P + Q
Sbjct: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002
Query: 3025 QTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDA 3084
+ L K+ + ++ AQL + E+ + + LQ+ L++HQ +E ++ DA
Sbjct: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062
Query: 3085 WLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRR 3144
WLT + +S++ G ++ V+ L + +AFRK + + + +LR+L T+E+
Sbjct: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRK-AAAAWEERFSSLRRLT-TIEK----- 2115
Query: 3145 YPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED 3204
I+A++S+ + L + LAA +AA L+ E+
Sbjct: 2116 ---IKAEQSK-QPPTPLLGRKFFGDPTELAA--------KAAPLLRPGGYERGLEPLARR 2163
Query: 3205 GGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAA-PGGLAKVQEAWAT 3263
+LS+ + + R E + E ++ + RL G++ PAA P E AT
Sbjct: 2164 ASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIP---GRVEPAALPAAPEDAAETPAT 2220
Query: 3264 LQAKAQERGQWLAQAAQGHA------FLGRCQELLAWAQE--RQELASSEELAEDVAGAE 3315
A Q R + Q + A QE + ++E R+ +E AE A
Sbjct: 2221 PAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHS 2280
Query: 3316 QLLGQHEEL--GQEIRECRLQAQDLRQEGQQL---VDNSHFMSAEVTECLQELE 3364
LG++E++ +E RE RL+ Q+ ++ + + A++ E LQE E
Sbjct: 2281 LTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKE 2334
Score = 286 bits (733), Expect = 2e-76
Identities = 484/2193 (22%), Positives = 852/2193 (38%), Gaps = 215/2193 (9%)
Query: 1568 ELEGHWAELERA-----CEARAQCLQQA---VTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
+++ W ELE+A RA+ ++Q + Q++ V+ E W+ E + LVS ++
Sbjct: 398 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF 457
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQL 1677
G + A + KH+A++ ++A Y ++ + + AQ L + +RV +R + Q
Sbjct: 458 GYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQW 517
Query: 1678 RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
L L R LE L L + +E + W+ + QA G+ A L K
Sbjct: 518 ALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM-EEMQAQLLSRECGQHLVEADDLLQK 576
Query: 1738 FAKFQHQVEMGSQRVAACRLLAE--SLLERGHSAGPMVR-QRQQDLQTAWSELWELTQAR 1794
+ + S+RV A A S L+ P V R + +EL E R
Sbjct: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636
Query: 1795 GHALRDTETTLRVHRDLLEVLTQVQEKATSLPN----------------NVARDLCGLEA 1838
L + + + ++L E + ++K L A DL
Sbjct: 637 RAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTAR 696
Query: 1839 QLRSHQGLERELVGTERQLQELLETAGRVQKL--CPGPQAHAVQ-----QRQQAVTQAWA 1891
L H+ L+ EL G LQ+ L + GP A V +R + + W
Sbjct: 697 LLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ 756
Query: 1892 VLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQ 1951
L+ +R +L+ AR L +F + W + + + +S H+
Sbjct: 757 RLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHR 816
Query: 1952 WLRAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQR--DQVYQTWAR 2005
L E+EA L +Q LG A+G V ++R ++ ++ +V + A
Sbjct: 817 ALTGEVEAHRGPVSGLRRQLATLGG----ASGAGPLVVALQVRVVEAEQLFAEVTEVAAL 872
Query: 2006 KQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTA 2065
+++ L+ E E + +E L + + S+++VE + + E + + +
Sbjct: 873 RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNS 932
Query: 2066 QDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASF 2119
+ + ++ L VR L R R+ EL E R + A LL+ +
Sbjct: 933 LMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENH 992
Query: 2120 TQAATQAEDWIQAWAQQLKE-PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGE 2178
+ ++ + ++ P G L+ +L L EA +QA E ++ ++
Sbjct: 993 VLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGL------EAALQALEPRQAALLEEA- 1045
Query: 2179 ALLAQSHP-RAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWI- 2236
ALLA+ P +A + Q + L W L A G+ + FL +D W+
Sbjct: 1046 ALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLV 1105
Query: 2237 -QEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPE 2295
++ + G L LE L R + A I + S+ L +
Sbjct: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELG 1165
Query: 2296 EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS---RELDNVTKRIQEKEALI 2352
+ + L W H L ++ + E ++ H+ R+L ++ +E +
Sbjct: 1166 PGLALDEWLPHLELGW---HKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMAL 1222
Query: 2353 QALDCGKDLESVQRLLRKHEE----LEREVHPIQAQVESLE---REVGRLCQRSPEAAHG 2405
+ +ESV+ L++H + +E +Q V++ E R+ +++ EA
Sbjct: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTR 1282
Query: 2406 LRHRQQEV---AESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSP 2462
L + QE A+ W Q + + E L +L + E ++ A+ D +
Sbjct: 1283 LLEKNQENQLRAQQWMQ---KLHDQLELQHFLRDCHELDGWIHEKMLMAR------DGTR 1333
Query: 2463 APRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQE 2522
+ R + HQ AEL + + GQQL+ ++ +R+ L + Q
Sbjct: 1334 EDNHKLHKRWL--RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQC 1391
Query: 2523 LSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWK 2582
+ LE Q QL +A + + S ++++ L E L LA + L K
Sbjct: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 1451
Query: 2583 HKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQ-AMLLRKEALFRQAGTRRH 2641
+ +E +E ++ L+A L P ++ +G Q A+ R L RR
Sbjct: 1452 LQSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPLQERRR 1509
Query: 2642 RLEELRQLQAFLQDSQEVAAWLREKNLVALE-EGLLDTAMLPAQLQKQQNFQAELDASMH 2700
L ++L D + AW++E+ +A++ E + ++K Q + E+ A
Sbjct: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
Query: 2701 QQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRS 2760
+ +E+ L P +EA++ LE+L + W L++ ++++ L A + +
Sbjct: 1570 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 1629
Query: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
+ E+E WL E+ + + G+ +LL +LE V+ L Q +A +
Sbjct: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689
Query: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
GH ++ + + ++ + + +L+E +ERR ALE + L + R E W+ EK +
Sbjct: 1690 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESE--MSSHEALTRVVLGTGYKLVQAGHFAAHEVAAR 2938
A + + GQ V LQE+ SE M+ E L V +L++ GH AA +A
Sbjct: 1750 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIECGHTAAATMAEW 1808
Query: 2939 VQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDS-EDMGHSAE 2997
L +A A L R LL ++E +F ++ E + E+ L
Sbjct: 1809 KDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQL-QAVREAHAELL 3056
+ ++ R L A + DL+ ++ +LQ+ AA L + E + +A Q V + ELL
Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
Query: 3057 RRAE-ARGH--GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFD 3113
E AR H + L+ H R+ L +W+ A+ + D +D+ V+VL
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLL---SWMDGIASQIGAADKPRDVSSVEVLMNYHQ 1985
Query: 3114 AFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL 3173
+ E+++ ++ ++L +L IQAQ ++ E + + E L
Sbjct: 1986 GLKTELEAR-VPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWL 2044
Query: 3174 AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEV 3233
EVH F Q A + + L++ + G S+ V L ++H + A E+
Sbjct: 2045 QQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF 2104
Query: 3234 ARL---------------QTEACRLG--------QLHPAA-----PGGLAKVQEAWA--- 3262
+ L Q LG +L A PGG + E A
Sbjct: 2105 SSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARRA 2164
Query: 3263 --TLQAKAQERGQWLAQAAQGHAF---LGRCQELLAWAQERQELASSEELAEDVA---GA 3314
TL A+ + R ++ Q + + R E+ + A+ E+ AE A A
Sbjct: 2165 SDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAA 2224
Query: 3315 EQLLGQHEELGQEIRECRLQAQDL----RQEGQQLVDNSHFMSAEVTECLQELEGRLQEL 3370
EQ+ + E +E +A++L R E Q+ VD S + QE E
Sbjct: 2225 EQVRPRPER-----QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESA----EH 2275
Query: 3371 EEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDL 3430
E A +L R +++ +R E+ E L E S+ E+ + DL
Sbjct: 2276 EAAHSLTLGR------YEQMERRRERRERRLERQES-----------SEQEMPIRG--DL 2316
Query: 3431 EKLLAAQEEKFAQMQKTEMEQEL-----LLQPQELKPGRAGSSLTSFQWRP--------- 3476
K A + Q+Q+ E L L QP+EL PGR + L + P
Sbjct: 2317 VKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARD 2376
Query: 3477 -----------SGHQGLGAQLAETRDPQDAKG---------TPTMEGSLEFKQHLLPGGR 3516
G +G G++ + + Q T EG L K+ L R
Sbjct: 2377 RPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKREL-DANR 2435
Query: 3517 QPSSSSWDSCRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTF 3574
+ S+ SW S L L + D + A LL L A E +KH F
Sbjct: 2436 KSSNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVF 2495
Query: 3575 SLRLTSGAEILFAAPSEEQAESWWRALGSTAAQ 3607
L+ G+E L A EE+ W A+ S+ A+
Sbjct: 2496 KLQTQDGSEFLLQAKDEEEMNGWLEAVASSVAE 2528
Score = 261 bits (666), Expect = 1e-68
Identities = 423/1983 (21%), Positives = 762/1983 (38%), Gaps = 175/1983 (8%)
Query: 942 ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQVQLRDVLLQLEALQPGSSED 998
++ + WG+LE + E+ L + E L + +V +R+ L Q S+D
Sbjct: 398 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNEN--QRLVSQD 455
Query: 999 T----CHALQLAQKKTLVLE-------RRVHFLQSVVVKVEEPGYAESQPLQGQVETLQG 1047
A++ A KK +E RV + + + GY + + + Q +++
Sbjct: 456 NFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLR 515
Query: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
+ V R R + A Q QE ++ W E +QAQL S+E + A LL+
Sbjct: 516 QWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQ 575
Query: 1108 EHQDLLEEIHLWQERLQQLDAQSQPMAALD----------CPDSQEVPNTLRVLGQQGQE 1157
+H L +I ER++ L+A + + L C V L L +Q
Sbjct: 576 KHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR 635
Query: 1158 LKV-LWEQRQQW--LQEGLELQKFGREVDGFTATCANHQAWLHLDNLG-----EDVREAL 1209
+ L R W LQE E + + R+ + A G D+
Sbjct: 636 RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695
Query: 1210 SLLQQHREF-GRLLSTLGPRAEALRAHGEKLVQ---SQHPAAHTVR-----EQLQSIQAQ 1260
LL QH+ G L +ALR GE+LV + P A TV E+ S + +
Sbjct: 696 RLLAQHKILQGELGGRRALLQQALRC-GEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
Query: 1261 WTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAA-----HEPSGARRNILQ 1315
W RL+ + +R R+L + L ++ D+ L+ W+ + +AA H+ + +RR
Sbjct: 755 WQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR---- 810
Query: 1316 TLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTE 1375
++H A E+ A R V L++ L G + +++ + + E L ++TE
Sbjct: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEA--EQLFAEVTE 868
Query: 1376 ----RGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
R L+ A ++ ++ + + + E L S L + +Q R + L+
Sbjct: 869 VAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQ 928
Query: 1432 ESRTLAAKMA----ALASMAHGMAASPAILEETQKHL-----RRLELLQGHLAIRGLQLQ 1482
E +L ++ + + G S + Q HL R +EL++ Q
Sbjct: 929 EMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVE----------Q 978
Query: 1483 ASVELHQFCHLSNMELSWVAE--HMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQ 1540
E+ + N L VAE + +L + L+ ++A + +
Sbjct: 979 RKEEMSAVLLVENHVLE-VAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
Query: 1541 VQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDV 1600
+L LA QA + + +EL W L A +A + + A Q++ D+
Sbjct: 1038 QAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDL 1097
Query: 1601 SELEGWVEEKRPLVSSRD----YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQT 1656
W+ + + +EA L+ +H AL+EE+ + ++
Sbjct: 1098 DAFLDWLVRAQEAAGGSEGPLPNSLEEADA--LLARHAALKEEVDQREEDYARIVAASEA 1155
Query: 1657 LTGPEVPE--QQRVVQERLREQLRALQELAATRDRELEGTLRLH---EFLREAEDLQGWL 1711
L + E + E L +L + E ++ H FLR+ L
Sbjct: 1156 LLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVL 1215
Query: 1712 ASQKQAAKGGESLG--EDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSA 1769
+Q+ A G E G E E AL + F +E+ Q++ AE LL +G+
Sbjct: 1216 RNQEMALSGAELPGTVESVEEAL---KQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIY 1272
Query: 1770 GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNV 1829
G ++ L E Q L D RD E+ + EK +
Sbjct: 1273 GEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGT 1332
Query: 1830 ARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQA 1889
D L + HQ EL + L+++ ++ + P A +V+++ + Q
Sbjct: 1333 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQC 1391
Query: 1890 WAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSA 1949
WA L+ + + QL A A + S+A ++ L +E Q+ G +
Sbjct: 1392 WAELESTTQAKARQLFEA------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445
Query: 1950 HQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
+ L+ ++ + ++G+ A P + +EL + ++++ V + R E
Sbjct: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEP 1503
Query: 2010 LQAEQQEQLFLRECGRL-----EEILAAQE---VSLKTSALGSSVEEVEQLIRKHEVFLK 2061
LQ ++ L +E ++ +E+ QE ++++T G+ ++ V+Q I+K++ +
Sbjct: 1504 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRR 1562
Query: 2062 VLTAQDKKEAALRER---LKTLRRPR---VRDRLPILLQRRMRVKELAESRGHALHASLL 2115
+ A + + ER L +LR P VR L L ++E AE R L A+
Sbjct: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622
Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
+ + + E W+ + D + L+ L KH E V+ +EE + +++
Sbjct: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
+ ALL HP + ++S+R + + + L++ R LE + + ++V E W
Sbjct: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 1742
Query: 2236 IQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPE 2295
I EKEV +LGQD EH L+ + EF + G + +++ + +L
Sbjct: 1743 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG--MAGRERLAAVNQMVDELIECGHT 1800
Query: 2296 EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQAL 2355
+ + + LN WA + Q L + E+H + + +I+EK + L
Sbjct: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
Query: 2356 DCGKD----LESVQRLLRKHEELEREVHPIQAQVESLEREVGRL-CQRSPEAAHGLRHRQ 2410
+ S+QR LR E ++ + +QV L+ +L + E A + R+
Sbjct: 1861 TTPPEPRPSASSMQRTLR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
Query: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470
QEV + W +L S + R + + A + + +++LL + +Q+ + PR
Sbjct: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSV 1977
Query: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530
++ HQ K EL++ ++ + G+ LL + +I+ L L + W
Sbjct: 1978 EVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKW 2037
Query: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590
H LQQ LE+ F + WL ++E L S L + +E L+ +H+
Sbjct: 2038 DRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAA 2097
Query: 2591 EVQAGKISAL-------------------------------EATARG---LHQGGHPEAQ 2616
+ S+L E A+ L GG+
Sbjct: 2098 AAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGL 2157
Query: 2617 SALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL 2676
L R + L E R R+ E +LQ + E+ + L A E
Sbjct: 2158 EPLARRASDTLSAEVRTRVGYVRQELKPE--RLQPRIDRLPEIPGRVEPAALPAAPEDAA 2215
Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736
+T PA + Q + E S + +EL R + Q SE R E
Sbjct: 2216 ETPATPAAAE-QVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRP------E 2268
Query: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIE-VELRAPTVGQALPGVGELLGTQR 2795
Q++++ + A ++ R E E LE E E P G + G L
Sbjct: 2269 RQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVE 2328
Query: 2796 ELE 2798
+L+
Sbjct: 2329 QLQ 2331
Score = 127 bits (320), Expect = 2e-28
Identities = 150/634 (23%), Positives = 257/634 (40%), Gaps = 65/634 (10%)
Query: 2854 LEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--------------E 2898
LE ++ ++ A E +AW+ + L + Q + SLS V + LQ +
Sbjct: 305 LEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQ 364
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
+ NLE + S ++ R V ++ +LEKA H R A R L
Sbjct: 365 EKGNLEVLLFSIQSKLRAC--NRRLFVPREGCGIWDIDKAWGELEKA-EHEREAALRAEL 421
Query: 2959 LLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
+ Q+ E AQ+F ++ SWL E ++ ++ G+ A +A +++ EA + D+ A+
Sbjct: 422 IRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAY 481
Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
R++ + + A L + + +V AQ +V A L AR L++ L L ++
Sbjct: 482 EERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVF 541
Query: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGT 3136
+E + + W+ A S++ GQ L L +K ++ + + +V AL A
Sbjct: 542 QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE-RVEALNAAALR 600
Query: 3137 LE--RGAPRRYPHIQAQR-SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
+G P + R + + L + R L A+ + + Q E +
Sbjct: 601 FSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWA 660
Query: 3194 QEKTALMKGEDGG---------------HSLSSVRTLQQQHRRLERELEAMEKEVARLQT 3238
++K L++ GG H LSS L QH+ L+ EL L
Sbjct: 661 RDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRR----ALLQ 716
Query: 3239 EACRLGQLHPAAPGGL----------------AKVQEAWATLQAKAQERGQWLAQAAQGH 3282
+A R G+ AA G + A + W L+ A R + L +A H
Sbjct: 717 QALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALH 776
Query: 3283 AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
F LL W ++ LA++ + D A + +L QH L E+ R LR++
Sbjct: 777 QFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQL 836
Query: 3343 QQLVDNSHFMSAEVTECLQ----ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
L S + + LQ E E E+ E ALR Q ++ + ++ + E
Sbjct: 837 ATLGGASG--AGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACE 894
Query: 3399 AWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEK 3432
W+ E LL S+ DVE++ HR + L++
Sbjct: 895 LWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQ 928
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 869 bits (2245), Expect = 0.0
Identities = 604/2122 (28%), Positives = 1024/2122 (48%), Gaps = 90/2122 (4%)
Query: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
+E I+ L +Q+KTFTKW+N+ + +I +LY +L DG L++LLE++SG
Sbjct: 40 FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97
Query: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
E LP P++G++R+H LEN +AL FL+ +V + +G +IVDG+ L+LGLIW IILRF
Sbjct: 98 EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157
Query: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
QI I + +E S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH
Sbjct: 158 QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214
Query: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
HRPDL+D+ L+ HNL AF VAE++LGI LLDPEDV PDE+SI+TYV +Y
Sbjct: 215 HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274
Query: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
HY S++ +R+ K++ ETE + +Y L +DLL WI + L +R F +SL
Sbjct: 275 HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334
Query: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
++Q L AF+ +RT EKPP+ Q++G E LLF +Q+ ++A N++ + PH+G ++++++
Sbjct: 335 TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394
Query: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
W LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q
Sbjct: 395 AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
LA VEAA ++ +E E R +AL ++A L +E YH + R++ + W L
Sbjct: 454 LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513
Query: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
+ LQ +R+++ A+ L Q++ + ++E++ S G+ L EV +LLQ+H L+
Sbjct: 514 QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573
Query: 544 EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600
EA ++ G V + T + G +V+Q + L Q + L + R+A L
Sbjct: 574 EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633
Query: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
EQ+ + +F +E E+W+KE Q + G+DL+ + +KHKA E E+ A
Sbjct: 634 EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693
Query: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
+ + + AR+ P R + V W L+ LQ A Q+ DA
Sbjct: 694 EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753
Query: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
+ +WL++ L GQD+ A L ++H L + LE+Q +
Sbjct: 754 DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
P+ D + L
Sbjct: 810 ------------------------------------------PEEFRDSPDVTHRLQALR 827
Query: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899
+ Y+ + A A LR+ RL+EA+ L+ +LW+ EK+ L + P DTLE +++
Sbjct: 828 ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885
Query: 900 KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
F K L + V+ +A L + S ++++ Q+ L+ RW + L E
Sbjct: 886 VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945
Query: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016
+ + ++ V ++ +C T + D +E+ + D + + Q+K LER
Sbjct: 946 RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003
Query: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069
V +Q+ V ++ E +S P Q GQ + L+ L + +Q+ + + E
Sbjct: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063
Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128
Q+FLQ+ W Q + S+++ + A++LL++H + +EI Q+ Q++ ++
Sbjct: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
+ + P+ + L L L +WE R L + L Q+F ++ A
Sbjct: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
Query: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
+N + L + + A + +++ +F + + + G KLV + +
Sbjct: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
++E++Q I+ + + ++++ L +L+LQ + Q+ EL W+ +K L +
Sbjct: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303
Query: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
RN+ +H+A +EL + +E + G++L+ +P + +L+ L W+
Sbjct: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363
Query: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
L E+ L A + L+ D + + +E L+S + G+DL S R+ + ++
Sbjct: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423
Query: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488
+E + ++ L + M + + + R L+LL+ L R QL++S
Sbjct: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481
Query: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
Q E WV E +P Y L Q +K++ LQ E+ H +V+ VL G
Sbjct: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
Query: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608
+ L + Q + E+ L+ W L A R Q L+ A QQY+LD E E W+
Sbjct: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
Query: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668
E+ V S + +DE + ++ +H Q + Y ++++L AQ L PE +++
Sbjct: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
Query: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726
+ Q ++ + L+++A R R+LE L + RE +DL+ W+ S+K+ +G+
Sbjct: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720
Query: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785
D +H L KF F + +G +RV E L++ GHS + + + L W+
Sbjct: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
Query: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845
+L EL R L + R E+L + EK LP +V D E+ R H
Sbjct: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840
Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
EREL Q+Q+ + A R+Q G +A A+Q ++Q V+ AW L RR QL
Sbjct: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900
Query: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965
RF + RD SW + + ++ +E ++ SS L + HQ + AE+E R K +
Sbjct: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
Query: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025
+LG+ L ++E++E+L+ + +R ++ + W + ERL+ + F R+
Sbjct: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
Query: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
E L AQE L + G +V+ VE+LI++HE F +K A+ ER L +P
Sbjct: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073
Query: 2086 RDRLPILLQRRMRVKELAESRG 2107
+ L+ R + AE G
Sbjct: 2074 LE-----LKERQIAERPAEETG 2090
Score = 502 bits (1293), Expect = e-141
Identities = 430/1707 (25%), Positives = 753/1707 (44%), Gaps = 66/1707 (3%)
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
D+ AW L E R ALR+ + ++ LE L + ++ ++
Sbjct: 391 DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446
Query: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
+N DL +EA + H+ +E + E +++ L + A ++K Q + R+
Sbjct: 447 QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505
Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
+ + W+ LQ ++ RR +LE L + + W ++ L E +
Sbjct: 506 ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565
Query: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002
L H+ + A++ + + T + G + +Q+ + L+ +++
Sbjct: 566 LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062
A ++ +L+ ++ F E E + +E + G + V L RKH+ F
Sbjct: 626 AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685
Query: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
L D +EA K P++ R+ + + ++K+LA L +
Sbjct: 686 LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745
Query: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175
F A + W+Q A +L G + L KH+ F E++ VM + +
Sbjct: 746 FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
+ + + + +V+ RLQ LR+ ++ + LR Q L++ + D E W
Sbjct: 805 QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863
Query: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
+ EKE +M + D +DLE +Q R + + + + + + S ++ +
Sbjct: 864 MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
EVK Q + LN RW +F + ++ ++ AL +H + + +K I +K ++
Sbjct: 921 RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977
Query: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
++ D G+DL + + RK LER+V IQA+V++LERE +L PE + RQ+
Sbjct: 978 ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037
Query: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465
+ E W L+ Q + D L + +LQA LQ+L L Q+ A D P
Sbjct: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091
Query: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524
S EA ++L++H K E+D DS + +G++++ P + Q L GL+ +
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
Query: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584
+L W+ L Q L Q F ++ E L ++E +LA D L E + K +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
Query: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644
+E K+ + + L G+ + + Q + R +A L
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
Query: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704
+ +LQ FLQ+ QE+ W+ +K L + + + L + K Q F AEL + +
Sbjct: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331
Query: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764
+ EG++L+ + + ++LE L LW ELQ +++K L A + ++ +L
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391
Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
W+ +E +LR+ G+ L V +L + +E V+ + + L Q + EG
Sbjct: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451
Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884
+E+ RF L EPL R+ LE+ L+ RD ++E WV+E+LPLA +
Sbjct: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
Query: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
DYG +L V+ +++Q L++E+ H VL G +LV+A ++ R+ L+
Sbjct: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004
+ LR AA R L+ A EAQQ+ + EA +W+ E+ + S+++ E +L+
Sbjct: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624
Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
R +R +E + I++L A L S +PE +++ V + +A L AE R
Sbjct: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684
Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
L+ L QL+RET L+ W++ K A S + GQD + V +L +KF F +E ++GQ
Sbjct: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744
Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
+V + L I + + W L + I R + LAA++++H +
Sbjct: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243
AE+ G + EK + ED G S+ + + H EREL + +V + Q A RL
Sbjct: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863
Query: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299
G+ A +V AW L R L A F ++LL+W +
Sbjct: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359
++E DV+ E L+ H+ + EI + G+ L+ H S E+ E
Sbjct: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983
Query: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419
LQ++ R +E+ E W RW+R + + + AEAWL E L D+GH+V
Sbjct: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043
Query: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK 3446
VE L+ RH+ EK A+ E+FA ++K
Sbjct: 2044 VEKLIKRHEAFEKSTASWAERFAALEK 2070
Score = 399 bits (1026), Expect = e-110
Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)
Query: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
H KLV + A ++ E A++ R L R+E R++ L L + + + A
Sbjct: 384 HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436
Query: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
W+ E + A + G ++ K+ HEA E++ A V AL+ + +EL Q
Sbjct: 437 WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496
Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
+ I R + W L + R L+ ++L + + + + +++++ L S+E
Sbjct: 497 KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556
Query: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465
G+ L + L ++H+ +E++ K+ A+ + P ++++ HL
Sbjct: 557 GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
Query: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
+ E L A R QL+ S L +F + SW+ E S Y + L L
Sbjct: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
Query: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581
RKHK + E++ ++++ + A GHPQ I + +E+ W +L+
Sbjct: 677 RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733
Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
+ LQ A F Q+ D +L+ W+++ L+S D G+DE AT L KH+ EEL
Sbjct: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
Query: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694
ME L+Q AQ PE+ R + + +L+AL+EL A R + L+
Sbjct: 794 ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847
Query: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
L L+ E + + W+ +++ A ED E H +F +++ ++
Sbjct: 848 LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904
Query: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809
L A SL+E GH V+Q Q L T W L R A+ ++ LRVH
Sbjct: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961
Query: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
D E + +K + + ++ RDL G+ A R GLER++ + ++ L + ++
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927
P Q + QRQ+ + + W LQ+ ++ + L L F + D+ +W +
Sbjct: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986
++ + E+ + L H ++ E++ + +Q+ + G++ + P +
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
+ L L + + + W + L Q F ++ + E IL+ QE +L S+
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098
E E IRK E FL KVL+ D + E L ++++++ ++ R +
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258
Query: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
E A+ L +L + +F Q + WI + V + R+ LKHQA
Sbjct: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317
Query: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
F AE+ +HE + ++ +G+ L+ + VSQ+L+ L + W++L+ + Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377
Query: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276
R+ LQ WI E ++ D G+DL ++ +L+ E + N + +G+
Sbjct: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437
Query: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
A + S+ D L ++ R + ++ + +R+ QL + A
Sbjct: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482
Query: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
+SR+L++ T ++E+ L Q+ D G +L++VQ ++K++ L+ E+ +VE + +
Sbjct: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
Query: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448
+L + + L R + SW +LR A R + L ++AQ+ L A E
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599
Query: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508
+ Q L D P+ A ML+ H + ++ + +I S Q LL+AGHP
Sbjct: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657
Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
I ++ +++ + L+ +E + +L+ L + +E+W+ KE +S
Sbjct: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625
+ + L + K ++ E A ++ + A L GH EA + +
Sbjct: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
Query: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
L TR L L + E+ + EK+ E+ LD + +
Sbjct: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
Query: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744
+ F+ EL Q Q+ Q RL +EAIQ + +E+ A W L D +
Sbjct: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804
+L + R +L +W+E I ++ + + V L+ + + A ++ +
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
Query: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864
++ A L ++ ++ H ++++ E+ ++++ R K + E + R L + +F
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
Query: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
RDA AW+ + P A+ D+G ++ +V L ++H+ E +S
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
Score = 324 bits (831), Expect = 9e-88
Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)
Query: 872 ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927
+L W+E QT+ + + A++L +Q + + F T V K + + E L +
Sbjct: 313 DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371
Query: 928 RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979
R N+ ++ + ++++ W LE + + + L + + E L +
Sbjct: 372 RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431
Query: 980 QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029
+R+ L Q Q D A++ A+KK T E RV L+ + ++E+
Sbjct: 432 AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
Query: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089
Y + + + + + + L +QE + R +R T A Q Q+ + W + ++A
Sbjct: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
Query: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146
L S E + + LL++H+ + +I + ++++ + A + D Q + +
Sbjct: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
Query: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206
+ L Q +EL + R+ L++ L KF E+D + + + G+D+
Sbjct: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
L L ++H+ F L L E + +V + + +++ + AQW +L+
Sbjct: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
Query: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325
+ ++ L + +++ D +L W+++ + + E G + L K+H+
Sbjct: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
EL +R +E L+Q + D+ RLQ LR ++ + + R LQ+A
Sbjct: 791 ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
Query: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
+ + + + + E L E L + +Q R L+ E +TL ++ +
Sbjct: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
Query: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
A+ + S +++ Q HL R + Q ++ R + +++ +H +C W
Sbjct: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
Query: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
+ + T L G ++ RK L+ +V A Q +V + + L S Q
Sbjct: 970 ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029
Query: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
+ I ++ + LE W L+++ + + L + Q + D+ + + W+ + V+S D
Sbjct: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676
+L+ +H +++E+ + S + + ++ + + G PE + Q E L
Sbjct: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149
Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
AL + +R L L EF ++A+ + L++Q+ E + E A
Sbjct: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
KF F +E +V + L+ G+ ++++ Q ++ + E Q
Sbjct: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856
LRD ++ E+ + +K + + + L + HQ EL E
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
Query: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
L E ++ G+ Q + PQ A V Q+ +A+ + W LQ +++ L AR
Sbjct: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386
Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971
D W + + L+ ++ ++ +S L+ + + ++ R+ +L+ Q +G
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446
Query: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
++ A + K + L L ++ Q+ + A+ Q E E +
Sbjct: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494
Query: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085
+ + L SA G++++ V+ ++K++ ++L + E L+ + + +
Sbjct: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554
Query: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
+RL L R++E A R L + + A +AE WI + P
Sbjct: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614
Query: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203
D + L +H + V+ + + +A + + LL+ HP GE RLQG + KH+
Sbjct: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673
Query: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263
L+ R ++LE+ + + + D E WI EKE+ + ++GQD +H LR + R
Sbjct: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
Query: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323
+F + +G + +++ +L + E I + + LN WA + Q
Sbjct: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
Query: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383
L + ++H + I EK + D G D + + R H ERE+H +
Sbjct: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850
Query: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
QV+ + RL + E A +++++QEV+ +W L RR L + +
Sbjct: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
M ++LL + + Q++T PR +++ HQ AE+++ + + S G+ LL
Sbjct: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
H S +IR+ L + + W+ +L+ LE+ F E WL ++E
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030
Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
LAS + +E L+ +H+ E A + +ALE
Sbjct: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
Score = 299 bits (765), Expect = 4e-80
Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)
Query: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417
WE+L R+ +EL + + EQL R+ L + + + G DL
Sbjct: 396 WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455
Query: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472
+ + +K+H+ +E+++ ++ AL +A + I LR LQ
Sbjct: 456 AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515
Query: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532
L R +L+ ++ L + + W+ E H + + L + L +KHK ++
Sbjct: 516 LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575
Query: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589
++ +V+ + ++ Q Q I ++ LE + EL R L+Q
Sbjct: 576 DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
Query: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
+ ++F ++ E E W++EK + SS DYG+D + L L KH+A ++EL + +E+
Sbjct: 636 SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
Query: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706
+ Q A + + ++ + R++E Q L++LAA + L+ +F +A+D
Sbjct: 696 IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754
Query: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766
L+ WL + G E +G+D L K F ++E + A+ E
Sbjct: 755 LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813
Query: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826
+ P V R Q L+ + ++ R L++ V + + EK L
Sbjct: 814 RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872
Query: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
D L LE L++E+ Q+ + A + + P++ V+Q Q
Sbjct: 873 EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931
Query: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
+ W Q + +RR ++ A + + + + W + ++ + +G +
Sbjct: 932 LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
Query: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001
KLS + A ++AR ++ +Q Q + + +++ + + L++ + Q
Sbjct: 992 AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
Query: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061
+ +++ L Q Q FL++ + L+ + ++ + + S+ E EQL+++H
Sbjct: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
Query: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113
+ ++E + + + + D +LL +R+ + + ESR H L
Sbjct: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
Query: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173
L F + A QAE + L PP L + K + F ++ + + + S
Sbjct: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229
G L+A+ + + ++ +++Q + RK+ E ++A L LE +NFL+ Q +
Sbjct: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286
Query: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289
L WI +K + D+ D L + + + A + + +I QL
Sbjct: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339
Query: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349
+ P+ ++ Q+ L+ W Q L A + + ++ K I E
Sbjct: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399
Query: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409
+++ D GKDL SV R+L K + +E +V+ + ++ L +V + + +A + R
Sbjct: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459
Query: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469
++ E + + + + R L + ++E L AQ A T+
Sbjct: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512
Query: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529
+ ++++Q + E+ T + GQQL+ A D+ + L L+ L A
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
Query: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
+L+ A E Q + ++ E W+ +E + S+ + +L +H +
Sbjct: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632
Query: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648
+E I L + A+GL GHPE + + R Q + + A + A R+ +LE +
Sbjct: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691
Query: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706
L +++ ++ W+ EK LVA + D + K ++F E A + +
Sbjct: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
Query: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766
+RL+ GH + I E + L +W +L + ++ L + + R + E+
Sbjct: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811
Query: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814
++ P +V L A T V A LLG Q ++ D R A G+
Sbjct: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869
Query: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874
A+ ++ + + + +++L + RRT L + +FF A + ++W+
Sbjct: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919
Query: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934
+ + Q+ + +S+V L + HQ + +E+ + L G L+Q H A+ E
Sbjct: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979
Query: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994
+ ++QQ+ + + R L+ E QF + A +WL + L S D GH
Sbjct: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
Query: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053
+ ++ + L++R EA ++ +++ R L++ L L+ R+ E P A+ +E
Sbjct: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096
Query: 3054 ELLRRAEARGHGLQEQ 3069
E A H E+
Sbjct: 2097 ETAGEAPVSHHAATER 2112
Score = 165 bits (417), Expect = 9e-40
Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)
Query: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778
+ ++ W L++ ++ L Q+ E L R R E WL + +
Sbjct: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
G L V +E + AL AQ +E + + + + +L+
Sbjct: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
Query: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ L+E LQ RR LE L K F+D + W+ E + ++G+ L V L +
Sbjct: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955
+H+ +E++++ + + K + + + + R+ LE+ L AA
Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
R+ L+Q++ +F E+ EA SW+ E+ + S D G + L R+ +A + +L
Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
+E++ Q A + +RK P++ A+++ V +L A LQ+ Q
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
+ + L AWL +D GQD + L +K F +E++ + ++ G
Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
Query: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
E R +P +QA R + + D R + L A ++++ + M
Sbjct: 809 FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864
Query: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253
EK + + +L + +Q + L++E++ + ++ + A L +
Sbjct: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
Query: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308
+ + Q+ W Q ER + + A + H + C+E W ++ ++ S+++L
Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368
D+AG + + L +++ + + L +E QQL+D+ ++ + + LE Q
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
Query: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428
L+++ + E LQ Q L+ +AWL+ + + D S+ + E LL +H
Sbjct: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
Query: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481
++ + ++ + +++++ + + E LL Q L+ G + W H
Sbjct: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163
Query: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513
L L +DAK + + E+ HL P
Sbjct: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196
Score = 143 bits (361), Expect = 3e-33
Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909
A+E ++ K+ A + + W+++ + + ++ + SL+ V + LQ ++ +E
Sbjct: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
Query: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960
E V+L T ++A + + H+ V + +A A R E A R L+
Sbjct: 357 QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+Q Q A++F + +WL+E ++ ++ G+ A +A ++ EA + D A+
Sbjct: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077
R+ L+ A LE + ++ A+ + + L ++R L+ L L +L +
Sbjct: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
Query: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136
+ L W+ A S ++G+ L V+ L +K ++ G + K L T
Sbjct: 536 DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595
Query: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
+G P IQ + S +E +E L R L + + F E + ++E
Sbjct: 596 EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655
Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251
K + D G L+SV LQ++H+ E EL ++ + ++ EA R HP
Sbjct: 656 KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715
Query: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
+ +V W L+ A + L A F G +L AW Q+ L S E++ +D
Sbjct: 716 ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775
Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
L +H++ +E+ E R + L Q+ Q + S +VT LQ L Q++
Sbjct: 776 GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834
Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
LR QR E+ L + + E W+ E L + + ++ D+E++ HR L+
Sbjct: 835 AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894
Query: 3432 K 3432
+
Sbjct: 895 Q 895
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 643 bits (1658), Expect = 0.0
Identities = 543/2264 (23%), Positives = 998/2264 (44%), Gaps = 104/2264 (4%)
Query: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218
K L R+Q L++ Q F R+ + + + D +D LQ+H+ F
Sbjct: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88
Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
+ L G ++ H A+ T+R +L + QW L + ++ +LL +
Sbjct: 89 EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148
Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337
+L ++ ++ ++M W+ +K + E G ++ L K+ E ++++ A V +
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208
Query: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397
Q +L+ + +E I+T+ + + W+ L +R +L A + ++ R + +
Sbjct: 209 NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268
Query: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457
+++ E + S + G+DL S Q L ++H+ LE + L K+ AL + A + S L
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327
Query: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
TQ ++R EL+ IR L +L S L +F SWV E +
Sbjct: 328 SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387
Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
+ GA++L +H+E + E+ AH+ + SG++L A+GH + + E+ L
Sbjct: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
A L E R Q +Q + Q ++ D +++ W+ ++ + + D G + L+
Sbjct: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689
KH+ ++ L+ + LD+ A L + V R L + AL E A R
Sbjct: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
+L + L +F R++++L+ W+ + + A + +DP + K F+ ++
Sbjct: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625
Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
R+ A + L++ H A V R ++ + W +L E T+ +G LR+ + +R
Sbjct: 626 SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685
Query: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868
++ ++ + E L ++ +DL ++ + H LE ++ + ++ + A + Q
Sbjct: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
Query: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928
A ++++Q+A+ + L+ M R+ +L + L + V D +W R +
Sbjct: 746 D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803
Query: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
+ + + + G L HQ L+AE+ E + TQ G + ++V+
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
Query: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047
+L L + + + +++++ L+ Q Q + + E + +E + ++ G +
Sbjct: 864 KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923
Query: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099
E L++KHE + L+A ALRE+ ++ R+ L + L +
Sbjct: 924 SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983
Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159
+E+ +G L T + +DW + + VP ++ KL P A
Sbjct: 984 REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028
Query: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
A + E S+A + E + Q+ AG VS R++ + + + L + R LE
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088
Query: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276
+ F+ F + +L + WI EKE + ++G DLE L+++ +F+ + +
Sbjct: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
Query: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304
I +++ L+ + EEV+ + Q+
Sbjct: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206
Query: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
+LN RW S Q L A E+ R+ D + I+EK + + G DL
Sbjct: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
Query: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422
SVQ L RKHE ER++ + +V SL RL Q PE+A L+ + E+ ++W L
Sbjct: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326
Query: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482
RA +R+ L H Q+ + ++L+ +R + + + A +LE HQE +
Sbjct: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386
Query: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542
E+D+ + GQQLL GH S +I+Q L L+QE + LE AW + ++ L Q LE
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446
Query: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602
LQLF E+ E W+ ++E L +E D L +E L+ KH+ + + VQ KI+AL+A
Sbjct: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506
Query: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
A L GH R +L R L Q +R +L E + LQ F +D E+ AW
Sbjct: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
Query: 2663 LREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA--S 2720
+ EK A +E D + ++ QK Q F+AEL A+ + + + G L++ G A
Sbjct: 1567 ISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1626
Query: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTV 2780
+A++ RL L W L S +K KL++A + +++ + WL +E L +
Sbjct: 1627 DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY 1686
Query: 2781 GQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRF 2840
G+ L V LL + LEA + + + L QA + + V+++ + RF
Sbjct: 1687 GKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRF 1746
Query: 2841 KSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQH 2900
+ ++ RR L L +FFRD D+E +W++EK L ++DYG+ L+ V++L+++H
Sbjct: 1747 QKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKH 1806
Query: 2901 QNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLL 2960
+ LE+E+++HE + VL TG KL E+ R+ Q + L+ AA R L
Sbjct: 1807 KRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1866
Query: 2961 QQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRI 3020
+++ E QQF+ + E +W+ E+ ++ SED G + A Q LL++ EA + D R+
Sbjct: 1867 EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1926
Query: 3021 ERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETL 3080
+ L + N + ++++ + ++L + A R L E Q +
Sbjct: 1927 NDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 1986
Query: 3081 LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERG 3140
++++W+ K + ++ DYG+DL V+ L K + F +Q+ Q + + L L
Sbjct: 1987 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2046
Query: 3141 APRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAAELQGR 3192
+ I+A+ + + W +L AR + L A +F + A+
Sbjct: 2047 KHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSW 2106
Query: 3193 MQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACRLGQLH 3247
+ + +SL ++ L++ H L + + + +L Q ++ R+ +
Sbjct: 2107 FENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVAS-N 2165
Query: 3248 PAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAWAQE-R 3298
P + ++E W LQ +ER L + + F W QE R
Sbjct: 2166 PYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETR 2225
Query: 3299 QELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
L + E+ E L + QEIR R Q + + G
Sbjct: 2226 TYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2269
Score = 570 bits (1468), Expect = e-161
Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)
Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142
+++R +L R R KEL+ R L S F + A + E WIQ Q +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
P +L+ KL+ KHQAFEAEVQA+ + + + G ++++ H + + RL L + W
Sbjct: 75 PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
E L + M +G +L + +++L+ + WI +KE + +LGQDLEH L+++
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
EF+ + A + + ++ + +L E ++I ++ ++N W G L+ Q
Sbjct: 192 EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
+L GA E+ +R++D I+EKE L+ + D G+DL SVQ LLRKHE LER++ ++
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
+V++L E RL Q P +A ++ +++E+ +W Q+R+ A +R L+ ++ Q+ A
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
++L ++A ++ A +L+ HQE K E+D+ DS A +GQ LL
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
AGH S ++R+ L L +E ++L W+ + Q +Q ++LQLF E+++ W+ +E
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
L +E L D L +E LL KH+ E L Q KI+AL+ A L Q H + R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
A+L R+ AL +A RR +L + LQ F +DS E+ +W+ EK A +E D + L
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
++QK Q F+AEL A+ + L++ GQ+L+ H A + + R+ E+ +LW +L + ++
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
K KL++A + + R++E++E WL +E L + G+ L V L LEA V
Sbjct: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
+ + + QA+ F GH A++++++ L+ R+++L+EP+ R+ L L +
Sbjct: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
FRD ++E W++EK P+AA+ + G+ L V++L ++HQ L++E++ HE + V G
Sbjct: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
+V+ GHFAA +V A++ +L + L+A+A++RR L+ + +AQQ+ + EA SW+ E
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
+ ++ S D G ++ +ALL++ EA DL A+ I+ L++ A + P +
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968
Query: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100
+L + E R +G L ++ + + D AA + D Q
Sbjct: 969 KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028
Query: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
+LEE+ ++ Q Q ++ T E G+ + + ++E +
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074
Query: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220
L + + R L + + + A ELQ + EK A + E+ G L V LQ++
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134
Query: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240
+++L+A M +EV +Q + +
Sbjct: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194
Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
RL A + ++ E W +LQ A+ER Q L A + F E W +E+ +
Sbjct: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254
Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
+++ D+A + L +HE +++ + L + ++L+ SH SAE
Sbjct: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308
Query: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413
+L+ + EL +AW+ R + +S LQ+ +W+ GL+ +
Sbjct: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462
V+ E LL RHQ+ + A+ F + + Q+LL P
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414
Score = 552 bits (1423), Expect = e-156
Identities = 462/1933 (23%), Positives = 874/1933 (45%), Gaps = 88/1933 (4%)
Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
A+ I E+ Q++ + + R Q L+ + FQ + D ELE W++EK + S +
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676
Y +D + KHQA + E+ ++ +LD+T + G E R L Q
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
L E + +L +L ++LRE ED+ W+ + K+A E LG+D EH L
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
KF +FQ + +RV A L++ H +++ +Q ++ AW L L R
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855
L R +RD+ E ++ ++EK + ++ RDL ++A LR H+GLER+L E
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
+++ L A R+Q+ P +R++ +T W ++ +R A+L + L RF
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
RD SW ++ + +E + + + L HQ + E++A E ++ A + GQ L
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
A + EV+E+L L ++R + + W ++++ + QLF R+ +++ ++ QE
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089
L LG S++ VE L++KHE F K L+AQ++K AL E L + V R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147
LL RR + E A R L S + F + + + + W+ + + P +L+
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207
K++ KHQAFEAE+ A++ + ++ K G+ L+ +H EV+ R+ + W+ L +
Sbjct: 609 GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665
Query: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267
A L+G +L + +F + V+ E W+ E E + D G+DL + L+++
Sbjct: 666 ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
Query: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
+ A I I+ + Q ++ + + I +++ L R+ + ++ +Q+L
Sbjct: 726 DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387
+L + L R++++ I+EKE + + + GKDL VQ LL+KH+ L+ E+ + ++++
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
+ ++ + + AA ++ + E+ + W L+++A +RR+ L+ QAQ+ A E
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
+ + ++ + A +L++H+ ++L ++ SI R Q P
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
+ G E L+ + + + + ++ L+S K + W D
Sbjct: 963 TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014
Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627
+ P A ++ L +L + G I AL EA S R + +
Sbjct: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071
Query: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686
+L R+ LE+ + +++ E+ W+ EK + EE D + +
Sbjct: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726
K +FQ +L A+ + +++ + + L G A E A+Q++
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
Query: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
++EL W LQ ++++ L A E R R +E + W+E
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
L G L V L G +R+L A DK +L A+ ++ A
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307
Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886
+D++E+ L Q + SL + +R+ L L +F D + M+W+ L ++ +
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946
+ ++ L E+HQ +E+ + + G +L+ GH+A+ E+ ++ L++
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
Query: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006
A L +RR++L Q E Q F + +A +W+A R L++ED G S ++ +AL+++
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Query: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066
E + + +I LQ A L + + + ++ V + L + + L
Sbjct: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547
Query: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK 3126
E L Q R+ ++AW++ K TA + Y +D ++ +K AF E+ +
Sbjct: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHANADRI 1606
Query: 3127 VYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQA 3185
+ +ERGA ++A+ + + W+ L Q +++ L A++ +F
Sbjct: 1607 RGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTG 1666
Query: 3186 AAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQ 3245
+ + E AL+ ED G L+SV L ++H+ LE ++ A E + L ++A
Sbjct: 1667 IKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA---DS 1723
Query: 3246 LHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAWAQER 3298
L ++ ++V++ T+ + Q+ R L ++ + H F + +W +E+
Sbjct: 1724 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK 1783
Query: 3299 QELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTE 3358
+ L SE+ D+ G + L +H+ L E+ Q + G++L D++ E+ +
Sbjct: 1784 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ 1843
Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVS 3418
L + +EL++ A R QR ES Q+ +E+ EAW+ L+ DYG +++
Sbjct: 1844 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA 1903
Query: 3419 DVELLLHRHQDLE 3431
++ LL +H+ E
Sbjct: 1904 AIQGLLKKHEAFE 1916
Score = 531 bits (1367), Expect = e-150
Identities = 504/2221 (22%), Positives = 949/2221 (42%), Gaps = 142/2221 (6%)
Query: 827 FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884
F TI L + +E L + + +L +A L + C ++ W+ + ++
Sbjct: 115 FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174
Query: 885 QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944
+ + + +EV+Q K+E F T +A + EV+ A +L Q I+ +Q+E++
Sbjct: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
Query: 945 QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003
W +L+ L ++ +L + EV F ++ T +++ + + G + AL
Sbjct: 235 AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294
Query: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060
+ ++ LE +V L + ++++ + +Q + E L +Q++ A+R
Sbjct: 295 RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
Query: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120
R ++ Q FL + + L W ++A + + E++ DVA A+ LL HQ+ EI +
Sbjct: 355 ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414
Query: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180
+ + D Q + A S EV L VL ++ L LWE R+Q ++ ++LQ F R
Sbjct: 415 DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474
Query: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
+ + + +A+L ++LG+ + +LL++H +F + LS + AL KL+
Sbjct: 475 DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
Query: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300
Q+ H A V + ++ ++ L R+ +RR QL S LQ++ +D EL W+ EK
Sbjct: 535 QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360
A E N+ +++H+A E+EL A + ++AL++ G++L+ ++++ R+
Sbjct: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
Query: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
+ S W+ L +G +L++A QQ+Q R ++D + L ++EG L S + G+DL + Q
Sbjct: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475
LQK+H LE++ ++ + A G + I ++ + + R E L+ +
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
R +L S+ L Q E +W+ E P + T+ + L G Q+L +KH+ LQ E+
Sbjct: 775 ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
Query: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595
H+ +++ V G ++ GH A+ + + EL W L+ R Q L+ ++ QQ
Sbjct: 835 GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894
Query: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655
YF D +E E W+ EK P+V S DYG+DE + L+ KH+AL +L+ Y SS++ L + AQ
Sbjct: 895 YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
Query: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703
+ P E +E + AL + RE+ T++ + L E
Sbjct: 955 SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008
Query: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763
D QG++ + K + E+ L A Q Q++ + R+ E+
Sbjct: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059
Query: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823
V R + ++ + L EL + R L + + R+ E+ + EK
Sbjct: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112
Query: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881
+L + V DL +E + +++L E +L+++ + A ++ + + AVQQ
Sbjct: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172
Query: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907
++ + + + W LQ+ E+R L A
Sbjct: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232
Query: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967
+ RF + W Q L + + +S H+ +L A L +
Sbjct: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289
Query: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019
LG+ A L P E LQ++ ++ Q W+ +++ +L Q F
Sbjct: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344
Query: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079
L + L + + + L V E L+ +H+ + A+ A + +
Sbjct: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404
Query: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
L P ++ +L IL Q R +++ R L L + F + QAE+W+ A
Sbjct: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463
Query: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192
+ GD D ++ L+ KH+ F+ + EE + ++ + L+A H G++S
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523
Query: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252
R + W L+ M + +L + + +F + VD EAWI EK + +
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTAS----DESY 1579
Query: 2253 EHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRD--PEEVKIICQRRSQLNNR 2310
+ ++ + ++ + A IR + D+ L R + R + L ++
Sbjct: 1580 KDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQ 1639
Query: 2311 WASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRK 2370
W Q+L+ A + + + + + E EAL+ + D GKDL SV LL+K
Sbjct: 1640 WQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 1699
Query: 2371 HEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREA 2430
H+ LE ++ + +++ L + L S ++ ++ + + +++S A RR
Sbjct: 1700 HQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK 1759
Query: 2431 LDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
L+ H+ + + + + + + + R + + ++H+ +AEL + +
Sbjct: 1760 LNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPA 1819
Query: 2491 ISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSV 2550
I TG++L +I+Q LA + L+ +L+++LE Q F+++V
Sbjct: 1820 IQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANV 1879
Query: 2551 EKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQG 2610
E+ E W+ K +ASE D LA ++ LL KH+ E D V +++ + + L +
Sbjct: 1880 EEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKK 1939
Query: 2611 GHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-NLV 2669
+ ++ + + + + L + A R+ +L+E F + V +W+ EK N +
Sbjct: 1940 NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSL 1999
Query: 2670 ALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQERLE 2728
++ D + + L KQ+ F A L A + + +LL H S+AI+ R
Sbjct: 2000 KTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHA 2059
Query: 2729 ELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRAPTV 2780
L W +L NS + KL +A R + +W E E +L P
Sbjct: 2060 SLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVR 2119
Query: 2781 GQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------AQDV 2829
+L + L RE A A+A Q R+ + +
Sbjct: 2120 CNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEAL 2175
Query: 2830 EEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL-----AAA 2883
EE R L + K LQ E+R E L +F + A+ W+QE
Sbjct: 2176 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMV 2235
Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
++ G S + + +HQ + + S + + + L+ + H QQ +
Sbjct: 2236 EESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWD 2295
Query: 2944 K 2944
+
Sbjct: 2296 Q 2296
Score = 512 bits (1318), Expect = e-144
Identities = 547/2416 (22%), Positives = 1014/2416 (41%), Gaps = 213/2416 (8%)
Query: 571 SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630
+ E +Q + + + L RR LE + + F R+ EE E W++E Q + +
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69
Query: 631 ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
+D + + G LQKH+A EAEV + V L G + + R +
Sbjct: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 691 GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750
W+LL ++ +G +L A ++QY + + W+ ++ + + GQD E L +
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 751 RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810
+ E AA R+ E + A+
Sbjct: 190 K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213
Query: 811 PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870
K+ P+ + I QD ++ ++ L+ LA R+ +L A + F
Sbjct: 214 -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
Query: 871 GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928
E W++++ L+ D V L K+E LA + + + A++L+Q
Sbjct: 265 DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324
Query: 929 YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988
+P ++TQIQ ++EEL W Q+ L E+ +L S + FL + + ++ +
Sbjct: 325 HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384
Query: 989 EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041
A + S AL L + + E H + +E G A S ++ +
Sbjct: 385 NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441
Query: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101
+ L + E R ++ + Q F ++++Q+ W +A L ++++ + S
Sbjct: 442 LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501
Query: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161
+ LL++H+D + + +E++ LD + + + ++V L + L
Sbjct: 502 VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561
Query: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221
+R+ L + LQ+F R+ D + N + D +D +Q+H+ F
Sbjct: 562 AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620
Query: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
LS R +AL G+KL+ H A V ++ + + W +L +E + +L + Q
Sbjct: 621 LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680
Query: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
Q++ ++V ++ W+ E +G +A+ + N+ K+H E+++ A + ++ +
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
R+ E+I+ + + L +++EAL M R +L + + +QL R ++D + +
Sbjct: 741 ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800
Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455
+ E S+ G+DL Q L K+HQ L++E R A A + G A+
Sbjct: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860
Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
+ + + ++ E L+ + R L+ S++ Q+ +N SW+ E P T Y +
Sbjct: 861 VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574
+ A++L +KH+ L ++ A+ +Q + QAQ +Q +
Sbjct: 921 DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969
Query: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
EL A + + VT ++ L+ + + W E V+ R G AA ++ +
Sbjct: 970 ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681
+ Q+ E + +EE Q + L ++ Q R+ +E ++ E +L
Sbjct: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
Query: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741
EL R LE + + REA +LQ W+ ++K+AA E +G D E L KF F
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
Query: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779
Q ++ R+ +AE L G A + +QQ+
Sbjct: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196
Query: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
L W L +L + R L R HRD E ++EK +L
Sbjct: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256
Query: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884
+N DL ++A R H+G ER+L ++ L ETA R+ + P A +Q++
Sbjct: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315
Query: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944
+ QAW+ L +R +QR+A+L + L RF + RD SW +R + +E +++ +
Sbjct: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
Query: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004
L HQ R E++AR +Q Q GQQ L + E++++L L +R + + W
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435
Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
+++ L + QLF R+C + E +AA+E L T G S++ VE LI+KHE F K +
Sbjct: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
Q++K AAL+ L + + R +L R R+K + L S +
Sbjct: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
Query: 2119 FTQAATQAEDWIQAWAQQLKEP--VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
F++ + E WI Q + P +++ K + KHQAFEAE+ A+ + + V
Sbjct: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQ---KHQAFEAELHANADRIRGVIDM 1612
Query: 2177 GEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEA 2234
G +L+ + E V RL L W+ L Q A + Q+L++ F + +
Sbjct: 1613 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1672
Query: 2235 WIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
W+ E E + D G+DL L + +L E ++ D + D + S +D +
Sbjct: 1673 WLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSSAF 1730
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
D +VK +R +N R+ + +L + +H R++D+ I+EK+ L+
Sbjct: 1731 DTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLV 1787
Query: 2353 QALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQE 2412
+ D G+DL VQ L +KH+ LE E+ + ++ + +L + ++ R +
Sbjct: 1788 GSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQ 1847
Query: 2413 VAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARR 2472
E W +L+ A R + L+ + Q+ A ++E + + + +
Sbjct: 1848 FVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQG 1907
Query: 2473 MLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE 2532
+L++H+ + + D ++ + GQ L+ + +I + GL ++S LE A +
Sbjct: 1908 LLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQ 1967
Query: 2533 HQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEV 2592
+ +L + F + +E W+ KE+SL ++ L+ ++ LL K + + L+
Sbjct: 1968 RKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA 2027
Query: 2593 -QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ--- 2648
Q I+ + A L H ++++ R +++ R L + R+ +L E +
Sbjct: 2028 FQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFR 2087
Query: 2649 -----LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL-- 2695
F + + +W EE L D + A + F++ L
Sbjct: 2088 KVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS 2142
Query: 2696 -DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-- 2752
A +Q EL R+ + +P + E LEE W LQ +++ +LQK
Sbjct: 2143 AQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQRR 2199
Query: 2753 --EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLGTQ 2794
E +LR+ + N W++ L + T+ L E+ +
Sbjct: 2200 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2259
Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT-- 2852
+L+ D A EAL+ + LAQ ++ + ++ +L + +Q R T
Sbjct: 2260 SQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTG 2319
Query: 2853 ----ALEARSLLLKFF 2864
AL+ S++ K F
Sbjct: 2320 VTEEALKEFSMMFKHF 2335
Score = 480 bits (1235), Expect = e-134
Identities = 505/2349 (21%), Positives = 983/2349 (41%), Gaps = 163/2349 (6%)
Query: 936 IQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGS 995
IQ +++++ R+ + + L + +L S F ++ + ++ E LQ S
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQ------EKLQIAS 68
Query: 996 SEDTCHALQLAQK--KTLVLERRVHFLQSVVVKVEEPG-------YAESQPLQGQVETLQ 1046
E+ L K K E V +VK++E G + S+ ++ ++ L
Sbjct: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
Query: 1047 GLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLL 1106
+ + E++ ++ + + Q +L+E + ++ W +A + S+E+ D+ + L
Sbjct: 129 RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
++ ++ ++ +ER+ +++ + + P+ + + + Q LK L QRQ
Sbjct: 189 KKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
Query: 1167 QWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLG 1226
L E+Q+F R+VD + + + D+ G D+ +LL++H R L+ L
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
+ +AL A ++L QS +A ++ + + + W +++ + +R +L S +LQ +
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 1287 DVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
D +L W+ E K L+ A E + L RH+ + E+ A ++ + G+ LL
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEG 1405
+ ++++ +L L + AL R + +Q + R + + + E
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 1406 ALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA-----HGMAASPAILEET 1460
L + + G L S + L K+H+ E K+ AL A + A +
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 1461 QKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGA 1520
L R L R QL S L QF S+ SWV E M + +Y + N
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN-L 607
Query: 1521 QSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERAC 1580
Q +KH+ + E+ A+Q ++ + +G+ L H + + E+ W +L A
Sbjct: 608 QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 1581 EARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEEL 1640
E + L++A QQ+ +V ++E W+ E ++S DYG+D L KH L+ ++
Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
Query: 1641 AIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH 1698
A + ++ + A+ G E + QE L + AL+E R ++L +LRL
Sbjct: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
+ R+ ED + W+ +K+ + G+D +L K Q ++ R+ A
Sbjct: 788 QLFRDVEDEETWI-REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
Query: 1759 AESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQV 1818
+++E GH A V+ + +L W L R L D+ + D E + +
Sbjct: 847 GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
Query: 1819 QEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
+EK + + +D EA L+ H+ L +L +Q L E A + C A
Sbjct: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA----QSCRQQVAP 962
Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESS 1937
+ + + A Q + R +++ +L + +D+ W V +
Sbjct: 963 TDDETGKELVLALYDYQEK-SPREVTMKKGDILTLLNSTNKDW--WKVEVN-----DRQG 1014
Query: 1938 QEPSSGPLKLSAHQWLRAELEAREKLWQQ--ATQLGQQALLAAGTPTKE---VQEELRAL 1992
P++ KL A+ +RE L ++ + L Q+ + TKE V ++ +
Sbjct: 1015 FVPAAYVKKLDP-----AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069
Query: 1993 QDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQL 2052
++ + + +++ L+ ++ + RE L++ + +E +L + +G+ +E+VE L
Sbjct: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVL 1129
Query: 2053 IRKHEVFLKVLTAQDKK-------------EAALRERLKTLRRPRVRDRLP--------- 2090
+K + F K L A + + E + E ++ +++ V +P
Sbjct: 1130 QKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTA 1189
Query: 2091 --------------------ILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWI 2130
L +R +++LAE R L ++ + F + A + ++WI
Sbjct: 1190 SPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWI 1249
Query: 2131 QAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE 2190
+ Q L DL KH+ FE ++ A + + S+ + E L+ QSHP + E
Sbjct: 1250 EEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE 1308
Query: 2191 -VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
+ ++ L + W L + R +L D + FL +WI ++ +L
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 2250 QDLEHCLQLRRRLREFRGN--------SAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301
+D+ L R +E R A + G + S ++K +++ I+
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK----QKLDILD 1424
Query: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361
Q R+ L W ++ + L+ LE+ + R+ + + +EA + D G L
Sbjct: 1425 QERADLEKAW-------VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
Query: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421
+SV+ L++KHE+ ++ ++ + ++ +L+ +L A + R+ EV + W +L+
Sbjct: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537
Query: 2422 SRAQKRREALDALHQAQKLQAMLQELLV-SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
++ ++R L Q+ + E+ +++L+ D S + P + ++HQ
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDES--YKDPTNIQSKHQKHQAF 1595
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQ 2538
+AEL + D I G L+ G S+ ++ LA L + L E +L+
Sbjct: 1596 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1655
Query: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKIS 2598
+A + Q F + ++ + WL E LASE LA + LL KH++LE D+ ++
Sbjct: 1656 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLK 1715
Query: 2599 ALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658
L + A L + + + R + + A +RR +L E +L F +D +
Sbjct: 1716 DLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDD 1775
Query: 2659 VAAWLREKN-LVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
+W++EK LV E+ D + +K + +AEL A Q + G++L
Sbjct: 1776 EESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT 1835
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
E IQ+RL + W EL+ + + +L+++ E + ++EE E W+ + +
Sbjct: 1836 IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS 1895
Query: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLL 2837
G L + LL E + + Q +++ + +++ + + L
Sbjct: 1896 EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLN 1955
Query: 2838 QRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQ 2897
+ L + +R+ L+ S L+F AD +W+ EK DYG+ LS+V+ L
Sbjct: 1956 GKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLL 2015
Query: 2898 EQHQNLESEMSS--HEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
+ + ++ + + E + + +L+ A H + + AR L K + L A +A
Sbjct: 2016 TKQETFDAGLQAFQQEGIANIT-ALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2074
Query: 2956 RRLLLQQAQE-----AQQFLTELLEA---GSWLAERGHVLDSEDMGHSAEATQALLRRLE 3007
R+ L +AQ FLT +A SW L +S E +AL +
Sbjct: 2075 RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHD 2134
Query: 3008 ATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQ 3067
A + L + +L + ++S + +P ++A+ E L + + R LQ
Sbjct: 2135 AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQ 2194
Query: 3068 EQLQ------------------LHQLERET---LLLDAWLTTKAATAESQDYGQDLEGVK 3106
++ + HQ +ET LL + + ++ T ESQ LE K
Sbjct: 2195 KEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQ-----LEATK 2249
Query: 3107 VLEEKFDAFR---KEVQSLGQAKVYAL---RKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
++ A R K+++ LG A AL K G +++ + R++
Sbjct: 2250 RKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQ---H 2306
Query: 3161 RLDQAIKAR 3169
L+Q I+AR
Sbjct: 2307 NLEQQIQAR 2315
Score = 478 bits (1229), Expect = e-134
Identities = 447/1913 (23%), Positives = 796/1913 (41%), Gaps = 172/1913 (8%)
Query: 244 HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293
HY S + + TV LL+L E L + QYEQ + L W+++++
Sbjct: 432 HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 294 LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349
L D DSL ++ LL F QE+ A + + RR
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 350 FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409
L L A +A+++R QL L + F+ L+ +
Sbjct: 550 AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592
Query: 410 AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469
+ D+A P++L + VQ+ EA + + R AL + L +++ +V
Sbjct: 593 MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649
Query: 470 ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527
A R EV W++LL+ L+G + + A+ Q + + VE L E++ S G
Sbjct: 650 AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707
Query: 528 QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587
+ L V L ++H LLEA V+AH + + Q + + E ++ K L +
Sbjct: 708 KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
Query: 588 SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647
+L + AR+ L +L+ + R+ E+EE W++E + G+DL + L+KH+
Sbjct: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
Query: 648 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707
AL+AE+ H+ + ++G + D + + W+ L+ + R L+
Sbjct: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Query: 708 TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767
+L QYFADA EA SW+RE+ + G+D+ +AE LL++H L L A+ + ++
Sbjct: 888 DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947
Query: 768 RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816
L EQ ++ + + L + P E G + D WK
Sbjct: 948 ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006
Query: 817 MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857
+ +PA DP +L+ Q ++ E + ++ + R+
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066
Query: 858 EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894
++ L+ GE LQ W+ ++ L + V + +
Sbjct: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126
Query: 895 EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941
EV+Q K+++F L + +++ AE L + Q +QQE
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186
Query: 942 -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
EL++RW L+ L E++ L + EV F ++ T+
Sbjct: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
Query: 979 VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034
+ + L G + ALQ ++ L +V+ L ++ +
Sbjct: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306
Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094
++ LQ + L + ++ QR + ++ Q FL + + L+ W ++ + S E
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Query: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154
++ DV A+ LL HQ+ EI Q + Q + A S E+ L +L Q+
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
Query: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214
+L+ W QR+ L + LELQ F R+ + A +A+L+ ++ G+ + +L+++
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
Query: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274
H +F + ++ + AL+A ++L+ + H A + + + +W RL+ + ++R +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
Query: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHV 1334
L S LQ++ +DV E+ W+ EK A+ E NI ++H+A E+EL A +
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRI 1606
Query: 1335 EALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQ 1392
+ +G L+ R C G ED ++ RL L +W+ L +K E+ +L++A +Q+
Sbjct: 1607 RGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTG 1666
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
++D L ++E L S + G+DL S L K+HQ LE++ ++ L S A +
Sbjct: 1667 IKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT 1726
Query: 1453 SPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPH 1507
S A K R R + ++ A R +L S LHQF + E SW+ E
Sbjct: 1727 SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLL 1786
Query: 1508 GSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQ 1567
Y L G Q+L +KHK L+ E+ AH+ +Q VL +G+ L+ + I ++
Sbjct: 1787 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1846
Query: 1568 ELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATL 1627
+ HW EL++ AR Q L++++ +QQ+ +V E E W+ EK LV+S DYG AA
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906
Query: 1628 RLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAA 1685
L+ KH+A + + ++ + ++ Q L ++ + + L ++ L++ AA
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966
Query: 1686 TRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQV 1745
R +L+ +F +A+ ++ W+ ++ + K + G D L TK F +
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGL 2025
Query: 1746 EMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
+ Q +A L + LL H + R L WS+L + AR L + ++
Sbjct: 2026 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2085
Query: 1805 LRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLERELVGTER 1855
R DL + S N DL ++A +H L +
Sbjct: 2086 FRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQA 2145
Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RAQLERA 1907
+L E +++ + +A+ + W LQ+ +++R R Q E
Sbjct: 2146 DFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRRQEEND 2204
Query: 1908 RLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
+L F + W R L VEES S HQ +RA +K
Sbjct: 2205 KLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKK 2264
Query: 1963 LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
+ + + +L K + L Q DQ+ Q R Q L+ + Q
Sbjct: 2265 IEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2313
Score = 466 bits (1200), Expect = e-130
Identities = 440/2060 (21%), Positives = 868/2060 (42%), Gaps = 91/2060 (4%)
Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
I E Q+ L R + +R +L+ S F + W+ E + S +Y +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
N Q +KH+ + EV+A+ G + ++ +G + + GH ++ I + EL W
Sbjct: 75 PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
L + L QA QY + ++ W+ +K +V+S + G+D L K +
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693
Q ++A + + E++Q A L + PE++ + Q+ + + L+ LA R +L G
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
+ F R+ ++ W+ +K+ + G D L K + + +V
Sbjct: 254 AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
A A+ L + + ++ ++++L T W ++ L R L D+ R D +
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
Query: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872
+ + V E KA + +A D+ G EA L HQ + E+ E + E+ + L
Sbjct: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430
Query: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
G A V+++ +++ A L E RR Q E+ L F +W ++ L
Sbjct: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
Query: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
E+ S L H+ L A+E+ + + + ++V A
Sbjct: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
L +R+ +++ R++ +L Q F R+ L+ + +++ T ++
Sbjct: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609
Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
++KH+ F L+A + AL + + L + V R+ ++ ++ E E
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669
Query: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
+G L + F + E W+ L DL + KH EA+V A
Sbjct: 670 KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
H++ + + + H A + ++ + L +E L++ M R Q+L D +
Sbjct: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789
Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
+ V+ E WI+EKE + G+DL L ++ + + AG + +
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
Query: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345
++ + E+VK + +LN +W + + +Q LE +L+ + + +
Sbjct: 850 MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
Query: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405
+EKE ++ + D GKD +S + LL+KHE L ++ + +++L RE + C++
Sbjct: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965
Query: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458
++ +A +Q +S + K+ + L L+ K ++ ++ V A ++ ++
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024
Query: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518
D P +LEE + + + + G L ++QV
Sbjct: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069
Query: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
E+ SL ++ + L+++ + + ++++W+ KE +L SE + L +E
Sbjct: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617
L K + DL+ ++ + A L G ++++
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
A A L+ R +L + A R L ++Q F +D+ E W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721
+ EKN + D A + A +K + F+ +L A + L +RL+Q ++E
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
Query: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781
+QE+ EL W L + ++ AKL + + R +L +W+ I + + +
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
+ + G LL +E +D +A +A Q + GH + +++++ L Q
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
Query: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
L + +RR L+ L F RD ++ W+ + +D G SL +V L ++H+
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
Query: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
+ + ++ E + +L+ AGH+A ++++R ++ L+A+ +R L
Sbjct: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
++Q QQF ++ E +W++E+ E Q+ ++ +A + +L A + RI
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNI-QSKHQKHQAFEAELHANADRIR 1607
Query: 3022 RLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERET 3079
+ L R + V A+L A+ + L++++ + L+E +
Sbjct: 1608 GVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGI 1667
Query: 3080 LLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER 3139
D WL+ A S+DYG+DL V L +K ++ S + ++ L A +L
Sbjct: 1668 KDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQADSLMT 1726
Query: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTAL 3199
+ ++ +R I ++++ +R L +H +H F + + + ++EK L
Sbjct: 1727 SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLL 1786
Query: 3200 MKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG----LA 3255
+ ED G L+ V+ L+++H+RLE EL A E + + +L + LA
Sbjct: 1787 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1846
Query: 3256 KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAE 3315
+ E W L+ A RGQ L ++ + F+ +E AW E+ L +SE+ + +A +
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906
Query: 3316 QLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWA 3375
LL +HE + + + D+ GQ L+ ++ ++ ++ L G++ +LE+A A
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966
Query: 3376 LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEK-LL 3434
R + E+ + + + E+W+ E L DYG +S V+ LL + + + L
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2026
Query: 3435 AAQEEKFAQMQKTEMEQELL 3454
A Q+E A + T ++ +LL
Sbjct: 2027 AFQQEGIANI--TALKDQLL 2044
Score = 454 bits (1168), Expect = e-127
Identities = 487/2267 (21%), Positives = 922/2267 (40%), Gaps = 175/2267 (7%)
Query: 368 LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414
LE AE R Q + R + + L TL R+ FQ A E ++++ Q+
Sbjct: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68
Query: 415 DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474
D+ P +L + +Q+ EA + G L E +++ E + + + R
Sbjct: 69 DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
Query: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534
E+ +W+ LL+ ++ + ++ Q ++ L+E E + + + S GQ L V
Sbjct: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
Query: 535 ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594
L ++ + + ++AH V+ + Q A+L E+++ K + Q L L
Sbjct: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245
Query: 595 ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653
R+ L + F R+ +E +W+KE Q + + GRDL+ + L+KH+ LE ++
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 654 ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710
+ +A+C + R L P + + E + W+ ++T R ARL +
Sbjct: 306 ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361
Query: 711 LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
+ ++ AD + SW+ E ++ + D A AE LL RH + + A + +
Sbjct: 362 RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
Query: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
E G+A A + +
Sbjct: 422 ESGQALLAAG---------------------------------------------HYASD 436
Query: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888
+ + LS++ +L L +LRR + E+ M L F ++ W+ KQ L + +
Sbjct: 437 EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 889 PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948
D++E + K+E+F +L+ + + A +L Q + +++ L R
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
Query: 949 QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005
L + QLA S + F ++ + + + + EA + P + + Q
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065
+ + + R+ L+ K+ + + + ++ + L K++ E + + E
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+Q F + + + LW V+ L S + D+ + Q L ++H L ++ Q+R+
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
+ Q++ D++ + L + + LK R+Q L + L LQ+ R+V+
Sbjct: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
Query: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245
+ N G+D+ +LL++H+ ++ PR +A+ G +V+ H
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
Query: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305
AA V+ +L + +W L+ ++ QRR+ L SLQ Q++ D E WM EK +
Sbjct: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363
G + + LK+HEA S+L A ++AL++ + + P E + + L
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
Query: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415
E R++T ++GD L + +++ Q +++L+ A QS+
Sbjct: 977 DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035
Query: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475
L + R +Q+++++R + M ++LE +K
Sbjct: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082
Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
R L+ S + +N W+ E + L + L +K + Q ++K
Sbjct: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141
Query: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565
A++ +++ + L + G + Q + +Q
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
Query: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
+EL W L++ E R+Q L A Q++ D E + W+EEK +++ +Y
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D A+ L KH+ + +LA + L +TA+ L PE +QE+ E +A
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320
Query: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
L A R +L + L FL + DL W+ + E L +D A L
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
+ + + +++ + A + LL GH A P ++Q+ L ++L + R
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855
L HRD + + + L D L +EA ++ H+ ++ + E
Sbjct: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499
Query: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914
++ L A Q + G A + R+ V W L+ +M ++R++L ++ L +F
Sbjct: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQA 1974
V + +W + Q +ES ++P++ K HQ AEL A + +G
Sbjct: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSL 1616
Query: 1975 LLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAA 2032
+ E V+ L AL DQ + Q A K ++L+ ++Q F + L+
Sbjct: 1617 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE 1676
Query: 2033 QEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------RPRVR 2086
E L + G + V L++KH++ ++A + + L + +L +V+
Sbjct: 1677 VEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVK 1736
Query: 2087 DRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
D+ + R ++K +A SR L+ S + F + E WI+ + DL
Sbjct: 1737 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1796
Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
KH+ EAE+ AHE + V G+ L + E+ QRL +HW++L+
Sbjct: 1797 TGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELK 1856
Query: 2207 QAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
Q A RGQ LE+ + +F+ V+ EAWI EK + D G L L ++ F
Sbjct: 1857 QLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFE 1916
Query: 2267 GNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQ 2324
+ D V D C + L KN EE I + LN + + + + +
Sbjct: 1917 TDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAAQRKAK 1971
Query: 2325 LEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ 2384
L+ + + D V I EKE ++ D G+DL SVQ LL K E + + Q +
Sbjct: 1972 LDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE 2031
Query: 2385 -VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQAQKLQA 2442
+ ++ +L + + R + + W Q L + A ++++ L+A +K++
Sbjct: 2032 GIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2091
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
+ A + + + + LEE + + D++ S+S A++ QL
Sbjct: 2092 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2151
Query: 2503 ----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
A +P++ + LE+ +L+ +E +L+LQ+
Sbjct: 2152 ELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2195
Score = 422 bits (1086), Expect = e-117
Identities = 399/1844 (21%), Positives = 810/1844 (43%), Gaps = 93/1844 (5%)
Query: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714
+G +V E +QER ++ L +EL+ R ++LE + R F R+AE+L+ W+ +
Sbjct: 4 SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63
Query: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774
Q A + +DP + K F+ +V+ S + ++ GH A +R
Sbjct: 64 LQIA--SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121
Query: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833
R +L W L E + +G L + ++ R+ +V+ + +K A + +DL
Sbjct: 122 TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181
Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGR-VQKLCPGPQAHAVQQRQQAVTQAWAV 1892
+E + + + ++ E ++ E+ + A + +Q+ P+ ++ +Q V AW
Sbjct: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE--QHPEEELIKTKQDEVNAAWQR 239
Query: 1893 LQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
L+ QR+ +L A + RF V + SW Q + ++ ++ +S L H+
Sbjct: 240 LKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEG 299
Query: 1953 LRAELEARE----KLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQE 2008
L +L A E L +A +L Q L+A ++Q + L +Q+ A +
Sbjct: 300 LERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHA 355
Query: 2009 RLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK 2068
RL + Q FL + L + + + L S V E L+ +H+ + A +
Sbjct: 356 RLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED 415
Query: 2069 KEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQA 2122
+ E + L VR++L +L + R + EL E R + + F +
Sbjct: 416 SFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
Query: 2123 ATQAEDWI-QAWAQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEAL 2180
Q ++W+ + A L E + GD D ++ LL KH+ FE + A EE +T++ + L
Sbjct: 476 TEQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533
Query: 2181 LAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKE 2240
+ +H +V+ R L L + R +L D + +F + D ++W+ EK
Sbjct: 534 IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK- 592
Query: 2241 VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKII 2300
+K + +D + L+ ++++ + A + + I ++ +L + + +
Sbjct: 593 MKTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649
Query: 2301 CQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKD 2360
R +++ + W +L A + +R ++++ + E E + + D GKD
Sbjct: 650 AARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD 709
Query: 2361 LESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQL 2420
L +VQ L +KH LE +V Q +++ + + + A ++ +Q+ + + L
Sbjct: 710 LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769
Query: 2421 RSRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQE 2479
+ R++ L D+L Q + + E ++ T+ + + + +L++HQ
Sbjct: 770 KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQA 828
Query: 2480 CKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
+AE+ I G ++ GH + D++ L L Q+ +L+ + + L+
Sbjct: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED 888
Query: 2540 ALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISA 2599
+L+ Q + + + E W+ KE + S E LL KH+ L DL I A
Sbjct: 889 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
Query: 2600 LEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658
L A+ Q P + ++ A+ +E R+ ++ + L L + +D +
Sbjct: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWK 1006
Query: 2659 VAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHP 2718
V R+ + A LD PAQ ++N E + +Q+++ + + + G
Sbjct: 1007 VEVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG-- 1060
Query: 2719 ASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAP 2778
++ R++++ L+ L + +K+ L+K+C+ L R EL+ W+ E L +
Sbjct: 1061 ---SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE 1117
Query: 2779 TVGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLA 2826
VG L V L Q++L+A ++K A ++E L+ + V++
Sbjct: 1118 EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYG 1177
Query: 2827 QDVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLK 2862
++ + L +R++SL++ +ER L + + +
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237
Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
F RDADE W++EK +YG L++V+ LQ +H+ E ++++ + T
Sbjct: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
+L+Q+ +A ++ + +L +A + L A +R+ L + + Q+FL++ + SW+
Sbjct: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
++ S+++ +ALL R + + +++A + + +Q L + + SP++
Sbjct: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
Query: 3043 AQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDL 3102
+L + + A+L + R L + L+L R+ + W+ + A ++D G L
Sbjct: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
Query: 3103 EGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERL 3162
+ V+ L +K + F K + ++ + K+ AL+ A L I ++R+ + W RL
Sbjct: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
Query: 3163 DQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRL 3222
+ + L + + F + E++ + EK ++ +++++ Q+H+
Sbjct: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQSKHQKHQAF 1595
Query: 3223 ERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQW 3274
E EL A + + ++ AC + A LA + + W L K+ E+ Q
Sbjct: 1596 EAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEKSQK 1653
Query: 3275 LAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQ 3334
L +A + F ++ W E + L +SE+ +D+A LL +H+ L +I +
Sbjct: 1654 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1713
Query: 3335 AQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRL 3394
+DL + L+ +S F +++V + + GR Q+++ A R + ES L + + +
Sbjct: 1714 LKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDM 1773
Query: 3395 EQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
+ E+W+ + L+ DYG ++ V+ L +H+ LE LAA E
Sbjct: 1774 DDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1817
Score = 312 bits (800), Expect = 3e-84
Identities = 457/2326 (19%), Positives = 896/2326 (38%), Gaps = 218/2326 (9%)
Query: 263 LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320
LLQ Q+ QY + D++ WI +K+ + + + L + L F F+T
Sbjct: 145 LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200
Query: 321 KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380
R+ + A L + Q H L + Q W + + ALQ
Sbjct: 201 HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246
Query: 381 QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437
++ E +RF S++K+ EQ++ D R LA+V+A +++ L
Sbjct: 247 RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
E + E + +AL AD L+Q S + ++EE+ W+++ + ++ D
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
+ L + + + E++ + +A LL RH + ++ AH
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 558 AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617
+ L ++ + + ++ K L++ + +L+ L RR EQ + F R+ E+ +
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 618 AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677
W+ + + N LG L + L+KH+ E + + L L
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 678 QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736
D R +A+ L R + R A+L + + Q+F D+ E SW+ E+ +++ + A
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796
+D + + +++H E L A + + LE+ G+ L VN
Sbjct: 601 Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642
Query: 797 RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856
+ + + + + ++ L +L+ +
Sbjct: 643 -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673
Query: 857 LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914
L EA F + +++LWL + L D V L+ ++ L +A +
Sbjct: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
Query: 915 WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974
++ A Q + ++ I+++QE L R+ L+ + +LA S+ + ++
Sbjct: 734 IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
Query: 975 GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
+ +R+ + G ++ Q Q + E R+ + + E
Sbjct: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
G+ ++ ++ ++ L + ++ + +QR + ++ Q + ++ + W + +
Sbjct: 854 GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913
Query: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
S + D SA+ LL++H+ L+ ++ + +Q L Q+Q P E
Sbjct: 914 GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967
Query: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207
G+EL + Q+ + ++K D T + ++ W + D G
Sbjct: 968 ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265
+ L + R LL G + ALR A +V +++ ++ + L
Sbjct: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
Query: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320
E+R+ L S + ++ EL QW+ EK E GA ++ L++
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137
Query: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357
+A ES L + E L+ G +E+ P + D +T
Sbjct: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197
Query: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408
++ L +W +L + ER L A + ++ R + KE +E+ AL
Sbjct: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257
Query: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467
+ G DL S Q LQ++H+ E + L K+ +L A + S P E+ Q+ L
Sbjct: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317
Query: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
L R Q +A S +L +F +SW+ S + + GA++L
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377
Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
+H+E + E+ A G Q G+ L A GH + I ++ L+ A+LE+A R
Sbjct: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
L Q + Q + D + E W+ + +++ D G + LI KH+ + + +
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701
+ L A L + + R + ++ R L+ + +L + L +F
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAES 1761
R+ ++++ W++ + Q A + +DP + K F+ ++ + R+ + S
Sbjct: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNS 1615
Query: 1762 LLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ 1819
L+ERG AG V+ R L W L + + + L++ + + + +
Sbjct: 1616 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1675
Query: 1820 E-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA 1878
E +A + +DL + L+ HQ LE ++ E +L++L A +
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSAFDTSQ 1734
Query: 1879 VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQ 1938
V+ ++ + + ++ RRA+L + L +F + D SW + + E+ +
Sbjct: 1735 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGR 1794
Query: 1939 EPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQ 1998
+ + H+ L AEL A E Q G++ +E+Q+ L + +
Sbjct: 1795 DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKE 1854
Query: 1999 VYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEV 2058
+ Q A + +RL+ + Q F+ E + + + + G ++ ++ L++KHE
Sbjct: 1855 LKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1914
Query: 2059 FLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRGHALHA 2112
F T +D+ +++ + ++ L + +++ A R L
Sbjct: 1915 FETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1974
Query: 2113 SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-HEEVMT 2171
+ F A E WI LK DL L K + F+A +QA +E +
Sbjct: 1975 NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIA 2034
Query: 2172 SVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN--------FL 2223
++ + LLA H ++ + R L K W L A R ++L + ++ FL
Sbjct: 2035 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2094
Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
F ++ +W + E + LE LR FR + + A ++
Sbjct: 2095 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQADFNQLA 2151
Query: 2284 DLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLRYQQQL 2325
+L Q+K+ +P EE KII +R +L N Q+
Sbjct: 2152 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2211
Query: 2326 EGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPI 2381
+ A H +E L + + ++E L L+ K RKH+ E+ +
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ----EIRAM 2258
Query: 2382 QAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALHQAQKL 2440
++Q++ +E ++G + + + H +A+ W QL + + L+ QA+
Sbjct: 2259 RSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2317
Query: 2441 QAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486
+ +E L + D + R HQE K+ L S
Sbjct: 2318 TGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2354
Score = 289 bits (740), Expect = 3e-77
Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)
Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
+ELS+L + +L+ + Q F E++E+W+ K + E DP ++ L
Sbjct: 30 KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82
Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
KH+ E +++ +G I L+ T + GH +++ R + + E L + +
Sbjct: 83 QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142
Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699
+L + ++L +L++ ++V W+ +K + E L LQK+ + FQ ++ A
Sbjct: 143 IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202
Query: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759
+ E+ + +L+Q HP E I+ + +E+ A W L+ + ++ KL A E R R
Sbjct: 203 ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262
Query: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815
++E +W++ E + + G+ L V LL G +R+L A DK +AL +A
Sbjct: 263 DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318
Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875
+ A ++ + L+ ++ +R ER L L +F D + +WV
Sbjct: 319 DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378
Query: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
E L A + ++ L ++HQ + E+ +HE + +G L+ AGH+A+ EV
Sbjct: 379 EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
Query: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995
++ L + A L RR +Q + Q F + + +W++++ L +ED+G S
Sbjct: 439 REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
Query: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055
++ +ALL++ E ++ L A +I L + A L + V + A+ L
Sbjct: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
Query: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115
RA R L + L Q R++ L +W+ K TA + Y +D ++ +K AF
Sbjct: 559 HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617
Query: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175
E+ S Q+++ AL K L + A+ + + + W++L +A + + L
Sbjct: 618 EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235
A++ F + +++ + E + +D G L++V+ LQ++H LE ++ A + +
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
Query: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
+ +A + + K QEA + L+ R Q LA + + ++
Sbjct: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
W +E++ +A+S +D+ G + LL +H+ L EI + + + Q+G +V+ HF
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
Query: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
+ +V L EL + + L+ + R Q +S Q+ +AE+W+ E ++
Sbjct: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464
DYG E LL +H+ L L+A +++ + P + + G+
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Score = 268 bits (684), Expect = 1e-70
Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)
Query: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674
A+ R Q +L R + RR +LE+ + Q F +D++E+ W++EK +A +E
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
D L +LQK Q F+AE+ A+ +L G ++ GH ASE I+ RL EL W
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
L + ++K KL +A + ++ R E++ +W+ E + + +GQ L V L
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851
E + + + + A ++E H L + +++ QR K L +R+
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248
Query: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
L + + +F RD DE ++W++EK L A+ D+G+ L++V+ L +H+ LE ++++ E
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ + +L Q+ +A ++ + ++L +R AA R L + Q+FL
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031
+ + SW+ E +++++++ +ALL R + K +++A + ++ L
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091
+ + S +V +L + E A LL E R ++ + L R+T +D W++ + A
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151
++D G L+ V+ L +K + F K + S + K+ AL + A L + + +
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547
Query: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
R + + L + R LA + + F + + EL+ + EK ++ S+
Sbjct: 548 RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606
Query: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267
++ Q+H+ E EL A + + L+ +L ++ A +A +V W L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327
+ +G L +A Q F +++ W E + +S++ +D+ + L +H L +
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387
+ + + + + +Q D HF + + + + L R + L+E R Q+ A+S L
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
Q+L + +E E W+ E + + G + V+ LL +HQ L+ +A E +
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
Score = 223 bits (569), Expect = 2e-57
Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
A ++ R QQ+ + + RR L+ + Q F + E W+ E+ + E+
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
Q L++ +A + +++A S I +L +T L+ S + S + +L +
Sbjct: 72 YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
LL + +G L + +L Q RE + W+ K A S++ GQDLE V+VL++K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
F+ F+ ++ + + +V + + A L + I+ ++ + AAW+RL R
Sbjct: 191 FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
L A EV F + E ++EK LM +D G L+SV+ L ++H LER+L A+E
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287
+V L EA RL Q HP + + +E W ++ A ER L + + FL
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
++L +W E + L +++ELA DVAGAE LL +H+E EI + + GQ L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407
H+ S EV E L L L E W LR Q+ + LQ + EQ + W++ E
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
LL D G S+ VE LL +H+D EK L+AQEEK + +
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
Score = 125 bits (314), Expect = 8e-28
Identities = 211/1116 (18%), Positives = 440/1116 (39%), Gaps = 122/1116 (10%)
Query: 376 SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426
++ LQ++ +L Q +L +R Q KA L +S FL D ++ +++
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Query: 427 -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479
EA ++R I + G FQA + L +++ ++ +++ ++ +
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425
Query: 480 WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
+ L+ QR+ + D L L ++ E A + + + + G L V L++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485
Query: 539 RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
+H+ + ++ ++ L +L ++ + + ++ + + L A + +R+
Sbjct: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545
Query: 599 LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
L ++ +F R+ +E EAW+ E Q + + +D + I QKH+A EAE+H +
Sbjct: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPTNIQSKHQKHQAFEAELHANAD 1604
Query: 659 VCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLVLQYF 716
++ G L R + +A A+ WQ L + + +L+ A +
Sbjct: 1605 RIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFN 1664
Query: 717 ADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAA 776
+ WL E + L G+D A+ LL++H LE + A L+ L Q
Sbjct: 1665 TGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD-- 1722
Query: 777 SARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQ 836
SL T ++ FD + + +
Sbjct: 1723 ----SLMTSSA---------------------------------------FDTSQVKDKR 1739
Query: 837 DHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEV 896
D ++ ++ ++++A RRA+L E+ L F + + W++++ +L+ D V
Sbjct: 1740 DTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGV 1799
Query: 897 MQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALK 954
L K++ LA + V + ++L +IQ++ + + W +L+ L
Sbjct: 1800 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLA 1859
Query: 955 REKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE 1014
+ +L S+E F+ + + + + + + G DT A+Q KK E
Sbjct: 1860 AARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKHEAFE 1916
Query: 1015 R-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
RV+ + + + + + + +++ L G + +++ AQR + E
Sbjct: 1917 TDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENS 1976
Query: 1068 ARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QERLQQL 1126
A F ++ + W + L++ + D++S Q LL + + + + QE + +
Sbjct: 1977 AFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2036
Query: 1127 DAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFT 1186
A + A S+ + L ++ +L R++ L LE Q R+V+
Sbjct: 2037 TALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVEDLF 2093
Query: 1187 ATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEALRAH 1235
T A + + +N ED + E +L + H F LS+ L A
Sbjct: 2094 LTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQL-AE 2152
Query: 1236 GEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQLQEWK 1285
++ ++S A++ +++++ W LQ + EQRR++ L+ QE+
Sbjct: 2153 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFA 2211
Query: 1286 QDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
Q QW++E E SG + L+ KR E+ A R ++ ++ +
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKKIEDL 2268
Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
G + + + GL +W+ L++ L+Q Q ++A ++
Sbjct: 2269 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEF 2328
Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436
+ ++G + HQ+ +S R+L
Sbjct: 2329 SMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2355
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 637 bits (1644), Expect = 0.0
Identities = 544/2269 (23%), Positives = 999/2269 (44%), Gaps = 109/2269 (4%)
Query: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218
K L R+Q L++ Q F R+ + + + D +D LQ+H+ F
Sbjct: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88
Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
+ L G ++ H A+ T+R +L + QW L + ++ +LL +
Sbjct: 89 EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148
Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337
+L ++ ++ ++M W+ +K + E G ++ L K+ E ++++ A V +
Sbjct: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208
Query: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397
Q +L+ + +E I+T+ + + W+ L +R +L A + ++ R + +
Sbjct: 209 NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268
Query: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457
+++ E + S + G+DL S Q L ++H+ LE + L K+ AL + A + S L
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327
Query: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
TQ ++R EL+ IR L +L S L +F SWV E +
Sbjct: 328 SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387
Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
+ GA++L +H+E + E+ AH+ + SG++L A+GH + + E+ L
Sbjct: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
A L E R Q +Q + Q ++ D +++ W+ ++ + + D G + L+
Sbjct: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689
KH+ ++ L+ + LD+ A L + V R L + AL E A R
Sbjct: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
Query: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
+L + L +F R++++L+ W+ + + A + +DP + K F+ ++
Sbjct: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625
Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
R+ A + L++ H A V R ++ + W +L E T+ +G LR+ + +R
Sbjct: 626 SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685
Query: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868
++ ++ + E L ++ +DL ++ + H LE ++ + ++ + A + Q
Sbjct: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
Query: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928
A ++++Q+A+ + L+ M R+ +L + L + V D +W R +
Sbjct: 746 D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803
Query: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
+ + + + G L HQ L+AE+ E + TQ G + ++V+
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
Query: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047
+L L + + + +++++ L+ Q Q + + E + +E + ++ G +
Sbjct: 864 KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923
Query: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099
E L++KHE + L+A ALRE+ ++ R+ L + L +
Sbjct: 924 SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983
Query: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159
+E+ +G L T + +DW + + VP ++ KL P A
Sbjct: 984 REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028
Query: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
A + E S+A + E + Q+ AG VS R++ + + + L + R LE
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088
Query: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276
+ F+ F + +L + WI EKE + ++G DLE L+++ +F+ + +
Sbjct: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
Query: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304
I +++ L+ + EEV+ + Q+
Sbjct: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206
Query: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
+LN RW S Q L A E+ R+ D + I+EK + + G DL
Sbjct: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
Query: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422
SVQ L RKHE ER++ + +V SL RL Q PE+A L+ + E+ ++W L
Sbjct: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326
Query: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482
RA +R+ L H Q+ + ++L+ +R + + + A +LE HQE +
Sbjct: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386
Query: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542
E+D+ + GQQLL GH S +I+Q L L+QE + LE AW + ++ L Q LE
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446
Query: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602
LQLF E+ E W+ ++E L +E D L +E L+ KH+ + + VQ KI+AL+A
Sbjct: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506
Query: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
A L GH R +L R L Q +R +L E + LQ F +D E+ AW
Sbjct: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
Query: 2663 LREKNLVALEEGLLD-----TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
+ EK A +E D + L ++ QK Q F+AEL A+ + + + G L++ G
Sbjct: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
Query: 2718 PA--SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVEL 2775
A +A++ RL L W L S +K KL++A + +++ + WL +E L
Sbjct: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
Query: 2776 RAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARR 2835
+ G+ L V LL + LEA + + + L QA + + V+++
Sbjct: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT 1746
Query: 2836 LLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRH 2895
+ RF+ ++ RR L L +FFRD D+E +W++EK L ++DYG+ L+ V++
Sbjct: 1747 INGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQN 1806
Query: 2896 LQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
L+++H+ LE+E+++HE + VL TG KL E+ R+ Q + L+ AA
Sbjct: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAA 1866
Query: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
R L+++ E QQF+ + E +W+ E+ ++ SED G + A Q LL++ EA + D
Sbjct: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926
Query: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
R+ + L + N + ++++ + ++L + A R L E Q
Sbjct: 1927 HKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
+ ++++W+ K + ++ DYG+DL V+ L K + F +Q+ Q + + L
Sbjct: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKD 2046
Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAA 3187
L + I+A+ + + W +L AR + L A +F + A+
Sbjct: 2047 QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKAS 2106
Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACR 3242
+ + +SL ++ L++ H L + + + +L Q ++ R
Sbjct: 2107 AFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFR 2166
Query: 3243 LGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAW 3294
+ +P + ++E W LQ +ER L + + F W
Sbjct: 2167 VAS-NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
Query: 3295 AQE-RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
QE R L + E+ E L + QEIR R Q + + G
Sbjct: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
Score = 570 bits (1468), Expect = e-161
Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)
Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142
+++R +L R R KEL+ R L S F + A + E WIQ Q +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
P +L+ KL+ KHQAFEAEVQA+ + + + G ++++ H + + RL L + W
Sbjct: 75 PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
E L + M +G +L + +++L+ + WI +KE + +LGQDLEH L+++
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
EF+ + A + + ++ + +L E ++I ++ ++N W G L+ Q
Sbjct: 192 EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
+L GA E+ +R++D I+EKE L+ + D G+DL SVQ LLRKHE LER++ ++
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
+V++L E RL Q P +A ++ +++E+ +W Q+R+ A +R L+ ++ Q+ A
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
++L ++A ++ A +L+ HQE K E+D+ DS A +GQ LL
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
AGH S ++R+ L L +E ++L W+ + Q +Q ++LQLF E+++ W+ +E
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
L +E L D L +E LL KH+ E L Q KI+AL+ A L Q H + R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
A+L R+ AL +A RR +L + LQ F +DS E+ +W+ EK A +E D + L
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
++QK Q F+AEL A+ + L++ GQ+L+ H A + + R+ E+ +LW +L + ++
Sbjct: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
K KL++A + + R++E++E WL +E L + G+ L V L LEA V
Sbjct: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
+ + + QA+ F GH A++++++ L+ R+++L+EP+ R+ L L +
Sbjct: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
FRD ++E W++EK P+AA+ + G+ L V++L ++HQ L++E++ HE + V G
Sbjct: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
+V+ GHFAA +V A++ +L + L+A+A++RR L+ + +AQQ+ + EA SW+ E
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
+ ++ S D G ++ +ALL++ EA DL A+ I+ L++ A + P +
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968
Query: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100
+L + E R +G L ++ + + D AA + D Q
Sbjct: 969 KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028
Query: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
+LEE+ ++ Q Q ++ T E G+ + + ++E +
Sbjct: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074
Query: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220
L + + R L + + + A ELQ + EK A + E+ G L V LQ++
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134
Query: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240
+++L+A M +EV +Q + +
Sbjct: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194
Query: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
RL A + ++ E W +LQ A+ER Q L A + F E W +E+ +
Sbjct: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254
Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
+++ D+A + L +HE +++ + L + ++L+ SH SAE
Sbjct: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308
Query: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413
+L+ + EL +AW+ R + +S LQ+ +W+ GL+ +
Sbjct: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462
V+ E LL RHQ+ + A+ F + + Q+LL P
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414
Score = 548 bits (1413), Expect = e-155
Identities = 463/1937 (23%), Positives = 876/1937 (45%), Gaps = 91/1937 (4%)
Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
A+ I E+ Q++ + + R Q L+ + FQ + D ELE W++EK + S +
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676
Y +D + KHQA + E+ ++ +LD+T + G E R L Q
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
L E + +L +L ++LRE ED+ W+ + K+A E LG+D EH L
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
KF +FQ + +RV A L++ H +++ +Q ++ AW L L R
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855
L R +RD+ E ++ ++EK + ++ RDL ++A LR H+GLER+L E
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
+++ L A R+Q+ P +R++ +T W ++ +R A+L + L RF
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
RD SW ++ + +E + + + L HQ + E++A E ++ A + GQ L
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
A + EV+E+L L ++R + + W ++++ + QLF R+ +++ ++ QE
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089
L LG S++ VE L++KHE F K L+AQ++K AL E L + V R
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
Query: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147
LL RR + E A R L S + F + + + + W+ + + P +L+
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
Query: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207
K++ KHQAFEAE+ A++ + ++ K G+ L+ +H EV+ R+ + W+ L +
Sbjct: 609 GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665
Query: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267
A L+G +L + +F + V+ E W+ E E + D G+DL + L+++
Sbjct: 666 ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
Query: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
+ A I I+ + Q ++ + + I +++ L R+ + ++ +Q+L
Sbjct: 726 DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387
+L + L R++++ I+EKE + + + GKDL VQ LL+KH+ L+ E+ + ++++
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
+ ++ + + AA ++ + E+ + W L+++A +RR+ L+ QAQ+ A E
Sbjct: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
+ + ++ + A +L++H+ ++L ++ SI R Q P
Sbjct: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
+ G E L+ + + + + ++ L+S K + W D
Sbjct: 963 TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014
Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627
+ P A ++ L +L + G I AL EA S R + +
Sbjct: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071
Query: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686
+L R+ LE+ + +++ E+ W+ EK + EE D + +
Sbjct: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726
K +FQ +L A+ + +++ + + L G A E A+Q++
Sbjct: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
Query: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
++EL W LQ ++++ L A E R R +E + W+E
Sbjct: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
Query: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
L G L V L G +R+L A DK +L A+ ++ A
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307
Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886
+D++E+ L Q + SL + +R+ L L +F D + M+W+ L ++ +
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946
+ ++ L E+HQ +E+ + + G +L+ GH+A+ E+ ++ L++
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
Query: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006
A L +RR++L Q E Q F + +A +W+A R L++ED G S ++ +AL+++
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Query: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066
E + + +I LQ A L + + + ++ V + L + + L
Sbjct: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547
Query: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ--DLEGVKVL--EEKFDAFRKEVQSL 3122
E L Q R+ ++AW++ K TA + Y +++ K+L +K AF E+ +
Sbjct: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHAN 1607
Query: 3123 GQAKVYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHS 3181
+ +ERGA ++A+ + + W+ L Q +++ L A++ +
Sbjct: 1608 ADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQN 1667
Query: 3182 FQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEAC 3241
F + + E AL+ ED G L+SV L ++H+ LE ++ A E + L ++A
Sbjct: 1668 FNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA- 1726
Query: 3242 RLGQLHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAW 3294
L ++ ++V++ T+ + Q+ R L ++ + H F + +W
Sbjct: 1727 --DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1784
Query: 3295 AQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSA 3354
+E++ L SE+ D+ G + L +H+ L E+ Q + G++L D++
Sbjct: 1785 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1844
Query: 3355 EVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYG 3414
E+ + L + +EL++ A R QR ES Q+ +E+ EAW+ L+ DYG
Sbjct: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1904
Query: 3415 HSVSDVELLLHRHQDLE 3431
+++ ++ LL +H+ E
Sbjct: 1905 DTLAAIQGLLKKHEAFE 1921
Score = 534 bits (1375), Expect = e-151
Identities = 509/2224 (22%), Positives = 951/2224 (42%), Gaps = 143/2224 (6%)
Query: 827 FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884
F TI L + +E L + + +L +A L + C ++ W+ + ++
Sbjct: 115 FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174
Query: 885 QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944
+ + + +EV+Q K+E F T +A + EV+ A +L Q I+ +Q+E++
Sbjct: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
Query: 945 QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003
W +L+ L ++ +L + EV F ++ T +++ + + G + AL
Sbjct: 235 AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294
Query: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060
+ ++ LE +V L + ++++ + +Q + E L +Q++ A+R
Sbjct: 295 RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
Query: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120
R ++ Q FL + + L W ++A + + E++ DVA A+ LL HQ+ EI +
Sbjct: 355 ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414
Query: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180
+ + D Q + A S EV L VL ++ L LWE R+Q ++ ++LQ F R
Sbjct: 415 DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474
Query: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
+ + + +A+L ++LG+ + +LL++H +F + LS + AL KL+
Sbjct: 475 DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
Query: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300
Q+ H A V + ++ ++ L R+ +RR QL S LQ++ +D EL W+ EK
Sbjct: 535 QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360
A E N+ +++H+A E+EL A + ++AL++ G++L+ ++++ R+
Sbjct: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
Query: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
+ S W+ L +G +L++A QQ+Q R ++D + L ++EG L S + G+DL + Q
Sbjct: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475
LQK+H LE++ ++ + A G + I ++ + + R E L+ +
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
R +L S+ L Q E +W+ E P + T+ + L G Q+L +KH+ LQ E+
Sbjct: 775 ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
Query: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595
H+ +++ V G ++ GH A+ + + EL W L+ R Q L+ ++ QQ
Sbjct: 835 GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894
Query: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655
YF D +E E W+ EK P+V S DYG+DE + L+ KH+AL +L+ Y SS++ L + AQ
Sbjct: 895 YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
Query: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703
+ P E +E + AL + RE+ T++ + L E
Sbjct: 955 SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008
Query: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763
D QG++ + K + E+ L A Q Q++ + R+ E+
Sbjct: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059
Query: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823
V R + ++ + L EL + R L + + R+ E+ + EK
Sbjct: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112
Query: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881
+L + V DL +E + +++L E +L+++ + A ++ + + AVQQ
Sbjct: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172
Query: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907
++ + + + W LQ+ E+R L A
Sbjct: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232
Query: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967
+ RF + W Q L + + +S H+ +L A L +
Sbjct: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289
Query: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019
LG+ A L P E LQ++ ++ Q W+ +++ +L Q F
Sbjct: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344
Query: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079
L + L + + + L V E L+ +H+ + A+ A + +
Sbjct: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404
Query: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
L P ++ +L IL Q R +++ R L L + F + QAE+W+ A
Sbjct: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463
Query: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192
+ GD D ++ L+ KH+ F+ + EE + ++ + L+A H G++S
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523
Query: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252
R + W L+ M + +L + + +F + VD EAWI EK D
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK--LQTASDESYKD 1581
Query: 2253 EHCLQLRRRLREFRGNSAGDTVGDA---CIRSISDLSLQLKNRD--PEEVKIICQRRSQL 2307
+QL + L + + + A + A IR + D+ L R + R + L
Sbjct: 1582 PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAAL 1641
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
++W Q+L+ A + + + + + E EAL+ + D GKDL SV L
Sbjct: 1642 ADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
Query: 2368 LRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR 2427
L+KH+ LE ++ + +++ L + L S ++ ++ + + +++S A R
Sbjct: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
Query: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487
R L+ H+ + + + + + + + R + + ++H+ +AEL +
Sbjct: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
Query: 2488 TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
+I TG++L +I+Q LA + L+ +L+++LE Q F+
Sbjct: 1822 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1881
Query: 2548 SSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGL 2607
++VE+ E W+ K +ASE D LA ++ LL KH+ E D V +++ + + L
Sbjct: 1882 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941
Query: 2608 HQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
+ + ++ + + + + L + A R+ +L+E F + V +W+ EK
Sbjct: 1942 IKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKE 2001
Query: 2667 NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQE 2725
N + ++ D + + L KQ+ F A L A + + +LL H S+AI+
Sbjct: 2002 NSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEA 2061
Query: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRA 2777
R L W +L NS + KL +A R + +W E E +L
Sbjct: 2062 RHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTD 2121
Query: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------A 2826
P +L + L RE A A+A Q R+
Sbjct: 2122 PVRCNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTM 2177
Query: 2827 QDVEEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL----- 2880
+ +EE R L + K LQ E+R E L +F + A+ W+QE
Sbjct: 2178 EALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGS 2237
Query: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
++ G S + + +HQ + + S + + + L+ + H Q
Sbjct: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQ 2297
Query: 2941 QLEK 2944
Q ++
Sbjct: 2298 QWDQ 2301
Score = 513 bits (1321), Expect = e-144
Identities = 548/2418 (22%), Positives = 1012/2418 (41%), Gaps = 212/2418 (8%)
Query: 571 SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630
+ E +Q + + + L RR LE + + F R+ EE E W++E Q + +
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69
Query: 631 ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
+D + + G LQKH+A EAEV + V L G + + R +
Sbjct: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 691 GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750
W+LL ++ +G +L A ++QY + + W+ ++ + + GQD E L +
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
Query: 751 RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810
+ E AA R+ E + A+
Sbjct: 190 K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213
Query: 811 PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870
K+ P+ + I QD ++ ++ L+ LA R+ +L A + F
Sbjct: 214 -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
Query: 871 GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928
E W++++ L+ D V L K+E LA + + + A++L+Q
Sbjct: 265 DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324
Query: 929 YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988
+P ++TQIQ ++EEL W Q+ L E+ +L S + FL + + ++ +
Sbjct: 325 HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384
Query: 989 EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041
A + S AL L + + E H + +E G A S ++ +
Sbjct: 385 NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441
Query: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101
+ L + E R ++ + Q F ++++Q+ W +A L ++++ + S
Sbjct: 442 LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501
Query: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161
+ LL++H+D + + +E++ LD + + + ++V L + L
Sbjct: 502 VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561
Query: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221
+R+ L + LQ+F R+ D + N + D +D +Q+H+ F
Sbjct: 562 AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620
Query: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
LS R +AL G+KL+ H A V ++ + + W +L +E + +L + Q
Sbjct: 621 LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680
Query: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
Q++ ++V ++ W+ E +G +A+ + N+ K+H E+++ A + ++ +
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
Query: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
R+ E+I+ + + L +++EAL M R +L + + +QL R ++D + +
Sbjct: 741 ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800
Query: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455
+ E S+ G+DL Q L K+HQ L++E R A A + G A+
Sbjct: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860
Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
+ + + ++ E L+ + R L+ S++ Q+ +N SW+ E P T Y +
Sbjct: 861 VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574
+ A++L +KH+ L ++ A+ +Q + QAQ +Q +
Sbjct: 921 DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969
Query: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
EL A + + VT ++ L+ + + W E V+ R G AA ++ +
Sbjct: 970 ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681
+ Q+ E + +EE Q + L ++ Q R+ +E ++ E +L
Sbjct: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
Query: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741
EL R LE + + REA +LQ W+ ++K+AA E +G D E L KF F
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
Query: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779
Q ++ R+ +AE L G A + +QQ+
Sbjct: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196
Query: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
L W L +L + R L R HRD E ++EK +L
Sbjct: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256
Query: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884
+N DL ++A R H+G ER+L ++ L ETA R+ + P A +Q++
Sbjct: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315
Query: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944
+ QAW+ L +R +QR+A+L + L RF + RD SW +R + +E +++ +
Sbjct: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
Query: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004
L HQ R E++AR +Q Q GQQ L + E++++L L +R + + W
Sbjct: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435
Query: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
+++ L + QLF R+C + E +AA+E L T G S++ VE LI+KHE F K +
Sbjct: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
Query: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
Q++K AAL+ L + + R +L R R+K + L S +
Sbjct: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
Query: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL----KHQAFEAEVQAHEEVMTSVA 2174
F++ + E WI Q + +L LL KHQAFEAE+ A+ + + V
Sbjct: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
Query: 2175 KKGEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLA 2232
G +L+ + E V RL L W+ L Q A + Q+L++ F +
Sbjct: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
Query: 2233 EAWIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLK 2290
+ W+ E E + D G+DL L + +L E ++ D + D + S +D +
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSS 1733
Query: 2291 NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEA 2350
D +VK +R +N R+ + +L + +H R++D+ I+EK+
Sbjct: 1734 AFDTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKL 1790
Query: 2351 LIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQ 2410
L+ + D G+DL VQ L +KH+ LE E+ + ++ + +L + ++ R
Sbjct: 1791 LVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRL 1850
Query: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470
+ E W +L+ A R + L+ + Q+ A ++E + + +
Sbjct: 1851 AQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAI 1910
Query: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530
+ +L++H+ + + D ++ + GQ L+ + +I + GL ++S LE A
Sbjct: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAA 1970
Query: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590
+ + +L + F + +E W+ KE+SL ++ L+ ++ LL K + + L
Sbjct: 1971 AQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGL 2030
Query: 2591 EV-QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ- 2648
+ Q I+ + A L H ++++ R +++ R L + R+ +L E +
Sbjct: 2031 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2090
Query: 2649 -------LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL 2695
F + + +W EE L D + A + F++ L
Sbjct: 2091 FRKVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
Query: 2696 ---DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
A +Q EL R+ + +P + E LEE W LQ +++ +LQK
Sbjct: 2146 SSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQ 2202
Query: 2753 ----EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLG 2792
E +LR+ + N W++ L + T+ L E+
Sbjct: 2203 RRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA 2262
Query: 2793 TQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT 2852
+ +L+ D A EAL+ + LAQ ++ + ++ +L + +Q R T
Sbjct: 2263 MRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2322
Query: 2853 ------ALEARSLLLKFF 2864
AL+ S++ K F
Sbjct: 2323 TGVTEEALKEFSMMFKHF 2340
Score = 474 bits (1219), Expect = e-133
Identities = 448/1918 (23%), Positives = 797/1918 (41%), Gaps = 177/1918 (9%)
Query: 244 HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293
HY S + + TV LL+L E L + QYEQ + L W+++++
Sbjct: 432 HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 294 LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349
L D DSL ++ LL F QE+ A + + RR
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 350 FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409
L L A +A+++R QL L + F+ L+ +
Sbjct: 550 AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592
Query: 410 AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469
+ D+A P++L + VQ+ EA + + R AL + L +++ +V
Sbjct: 593 MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649
Query: 470 ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527
A R EV W++LL+ L+G + + A+ Q + + VE L E++ S G
Sbjct: 650 AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707
Query: 528 QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587
+ L V L ++H LLEA V+AH + + Q + + E ++ K L +
Sbjct: 708 KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
Query: 588 SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647
+L + AR+ L +L+ + R+ E+EE W++E + G+DL + L+KH+
Sbjct: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
Query: 648 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707
AL+AE+ H+ + ++G + D + + W+ L+ + R L+
Sbjct: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
Query: 708 TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767
+L QYFADA EA SW+RE+ + G+D+ +AE LL++H L L A+ + ++
Sbjct: 888 DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947
Query: 768 RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816
L EQ ++ + + L + P E G + D WK
Sbjct: 948 ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006
Query: 817 MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857
+ +PA DP +L+ Q ++ E + ++ + R+
Sbjct: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066
Query: 858 EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894
++ L+ GE LQ W+ ++ L + V + +
Sbjct: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126
Query: 895 EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941
EV+Q K+++F L + +++ AE L + Q +QQE
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186
Query: 942 -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
EL++RW L+ L E++ L + EV F ++ T+
Sbjct: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
Query: 979 VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034
+ + L G + ALQ ++ L +V+ L ++ +
Sbjct: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306
Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094
++ LQ + L + ++ QR + ++ Q FL + + L+ W ++ + S E
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Query: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154
++ DV A+ LL HQ+ EI Q + Q + A S E+ L +L Q+
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
Query: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214
+L+ W QR+ L + LELQ F R+ + A +A+L+ ++ G+ + +L+++
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
Query: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274
H +F + ++ + AL+A ++L+ + H A + + + +W RL+ + ++R +
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
Query: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNI-----LQTLKRHEAAESELLA 1329
L S LQ++ +DV E+ W+ EK A+ E NI L ++H+A E+EL A
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
Query: 1330 TRRHVEALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387
+ + +G L+ R C G ED ++ RL L +W+ L +K E+ +L++A +Q+
Sbjct: 1607 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1666
Query: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447
++D L ++E L S + G+DL S L K+HQ LE++ ++ L S A
Sbjct: 1667 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1726
Query: 1448 HGMAASPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVA 1502
+ S A K R R + ++ A R +L S LHQF + E SW+
Sbjct: 1727 DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIK 1786
Query: 1503 EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHI 1562
E Y L G Q+L +KHK L+ E+ AH+ +Q VL +G+ L+ + I
Sbjct: 1787 EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEI 1846
Query: 1563 VEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRD 1622
++ + HW EL++ AR Q L++++ +QQ+ +V E E W+ EK LV+S DYG
Sbjct: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDT 1906
Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRAL 1680
AA L+ KH+A + + ++ + ++ Q L ++ + + L ++ L
Sbjct: 1907 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDL 1966
Query: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
++ AA R +L+ +F +A+ ++ W+ ++ + K + G D L TK
Sbjct: 1967 EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQET 2025
Query: 1741 FQHQVEMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799
F ++ Q +A L + LL H + R L WS+L + AR L
Sbjct: 2026 FDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLL 2085
Query: 1800 DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLEREL 1850
+ ++ R DL + S N DL ++A +H L
Sbjct: 2086 EAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RA 1902
+ +L E +++ + +A+ + W LQ+ +++R R
Sbjct: 2146 SSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRR 2204
Query: 1903 QLERARLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAEL 1957
Q E +L F + W R L VEES S HQ +RA
Sbjct: 2205 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2264
Query: 1958 EAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
+K+ + + +L K + L Q DQ+ Q R Q L+ + Q
Sbjct: 2265 SQLKKIEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
Score = 465 bits (1196), Expect = e-130
Identities = 440/2064 (21%), Positives = 868/2064 (42%), Gaps = 94/2064 (4%)
Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
I E Q+ L R + +R +L+ S F + W+ E + S +Y +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
N Q +KH+ + EV+A+ G + ++ +G + + GH ++ I + EL W
Sbjct: 75 PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
L + L QA QY + ++ W+ +K +V+S + G+D L K +
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693
Q ++A + + E++Q A L + PE++ + Q+ + + L+ LA R +L G
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
+ F R+ ++ W+ +K+ + G D L K + + +V
Sbjct: 254 AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
A A+ L + + ++ ++++L T W ++ L R L D+ R D +
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
Query: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872
+ + V E KA + +A D+ G EA L HQ + E+ E + E+ + L
Sbjct: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430
Query: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
G A V+++ +++ A L E RR Q E+ L F +W ++ L
Sbjct: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
Query: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
E+ S L H+ L A+E+ + + + ++V A
Sbjct: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
Query: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
L +R+ +++ R++ +L Q F R+ L+ + +++ T ++
Sbjct: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609
Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
++KH+ F L+A + AL + + L + V R+ ++ ++ E E
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669
Query: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
+G L + F + E W+ L DL + KH EA+V A
Sbjct: 670 KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
H++ + + + H A + ++ + L +E L++ M R Q+L D +
Sbjct: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789
Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
+ V+ E WI+EKE + G+DL L ++ + + AG + +
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
Query: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345
++ + E+VK + +LN +W + + +Q LE +L+ + + +
Sbjct: 850 MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
Query: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405
+EKE ++ + D GKD +S + LL+KHE L ++ + +++L RE + C++
Sbjct: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965
Query: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458
++ +A +Q +S + K+ + L L+ K ++ ++ V A ++ ++
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024
Query: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518
D P +LEE + + + + G L ++QV
Sbjct: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069
Query: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
E+ SL ++ + L+++ + + ++++W+ KE +L SE + L +E
Sbjct: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617
L K + DL+ ++ + A L G ++++
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
A A L+ R +L + A R L ++Q F +D+ E W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721
+ EKN + D A + A +K + F+ +L A + L +RL+Q ++E
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
Query: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781
+QE+ EL W L + ++ AKL + + R +L +W+ I + + +
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
+ + G LL +E +D +A +A Q + GH + +++++ L Q
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
Query: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
L + +RR L+ L F RD ++ W+ + +D G SL +V L ++H+
Sbjct: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
Query: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
+ + ++ E + +L+ AGH+A ++++R ++ L+A+ +R L
Sbjct: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL----RRLEATKRDLEAFS 3017
++Q QQF ++ E +W++E+ E + L ++ +A + +L A +
Sbjct: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
Query: 3018 PRIERLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
RI + L R + V A+L A+ + L++++ + L+E +
Sbjct: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF 1668
Query: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
D WL+ A S+DYG+DL V L +K ++ S + ++ L A
Sbjct: 1669 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQAD 1727
Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
+L + ++ +R I ++++ +R L +H +H F + + + ++E
Sbjct: 1728 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE 1787
Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG-- 3253
K L+ ED G L+ V+ L+++H+RLE EL A E + + +L +
Sbjct: 1788 KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ 1847
Query: 3254 --LAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
LA+ E W L+ A RGQ L ++ + F+ +E AW E+ L +SE+ + +
Sbjct: 1848 QRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTL 1907
Query: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
A + LL +HE + + + D+ GQ L+ ++ ++ ++ L G++ +LE
Sbjct: 1908 AAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLE 1967
Query: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
+A A R + E+ + + + E+W+ E L DYG +S V+ LL + + +
Sbjct: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
Query: 3432 K-LLAAQEEKFAQMQKTEMEQELL 3454
L A Q+E A + T ++ +LL
Sbjct: 2028 AGLQAFQQEGIANI--TALKDQLL 2049
Score = 450 bits (1158), Expect = e-125
Identities = 488/2272 (21%), Positives = 923/2272 (40%), Gaps = 180/2272 (7%)
Query: 368 LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414
LE AE R Q + R + + L TL R+ FQ A E ++++ Q+
Sbjct: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68
Query: 415 DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474
D+ P +L + +Q+ EA + G L E +++ E + + + R
Sbjct: 69 DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
Query: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534
E+ +W+ LL+ ++ + ++ Q ++ L+E E + + + S GQ L V
Sbjct: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
Query: 535 ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594
L ++ + + ++AH V+ + Q A+L E+++ K + Q L L
Sbjct: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245
Query: 595 ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653
R+ L + F R+ +E +W+KE Q + + GRDL+ + L+KH+ LE ++
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 654 ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710
+ +A+C + R L P + + E + W+ ++T R ARL +
Sbjct: 306 ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361
Query: 711 LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
+ ++ AD + SW+ E ++ + D A AE LL RH + + A + +
Sbjct: 362 RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
Query: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
E G+A A + +
Sbjct: 422 ESGQALLAAG---------------------------------------------HYASD 436
Query: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888
+ + LS++ +L L +LRR + E+ M L F ++ W+ KQ L + +
Sbjct: 437 EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 889 PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948
D++E + K+E+F +L+ + + A +L Q + +++ L R
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
Query: 949 QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005
L + QLA S + F ++ + + + + EA + P + + Q
Sbjct: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065
+ + + R+ L+ K+ + + + ++ + L K++ E + + E
Sbjct: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+Q F + + + LW V+ L S + D+ + Q L ++H L ++ Q+R+
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
+ Q++ D++ + L + + LK R+Q L + L LQ+ R+V+
Sbjct: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
Query: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245
+ N G+D+ +LL++H+ ++ PR +A+ G +V+ H
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
Query: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305
AA V+ +L + +W L+ ++ QRR+ L SLQ Q++ D E WM EK +
Sbjct: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363
G + + LK+HEA S+L A ++AL++ + + P E + + L
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
Query: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415
E R++T ++GD L + +++ Q +++L+ A QS+
Sbjct: 977 DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035
Query: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475
L + R +Q+++++R + M ++LE +K
Sbjct: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082
Query: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
R L+ S + +N W+ E + L + L +K + Q ++K
Sbjct: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141
Query: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565
A++ +++ + L + G + Q + +Q
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
Query: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
+EL W L++ E R+Q L A Q++ D E + W+EEK +++ +Y
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D A+ L KH+ + +LA + L +TA+ L PE +QE+ E +A
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320
Query: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
L A R +L + L FL + DL W+ + E L +D A L
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
+ + + +++ + A + LL GH A P ++Q+ L ++L + R
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855
L HRD + + + L D L +EA ++ H+ ++ + E
Sbjct: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499
Query: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914
++ L A Q + G A + R+ V W L+ +M ++R++L ++ L +F
Sbjct: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPL-----KLSAHQWLRAELEAREKLWQQATQ 1969
V + +W + Q +ES ++P++ L K HQ AEL A +
Sbjct: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
Query: 1970 LGQQALLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
+G + E V+ L AL DQ + Q A K ++L+ ++Q F +
Sbjct: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1676
Query: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------ 2081
L+ E L + G + V L++KH++ ++A + + L + +L
Sbjct: 1677 FWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD 1736
Query: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
+V+D+ + R ++K +A SR L+ S + F + E WI+ +
Sbjct: 1737 TSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED 1796
Query: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
DL KH+ EAE+ AHE + V G+ L + E+ QRL +H
Sbjct: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEH 1856
Query: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
W++L+Q A RGQ LE+ + +F+ V+ EAWI EK + D G L L ++
Sbjct: 1857 WKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKK 1916
Query: 2262 LREFRGNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
F + D V D C + L KN EE I + LN + +
Sbjct: 1917 HEAFETDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAA 1971
Query: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVH 2379
+ + +L+ + + D V I EKE ++ D G+DL SVQ LL K E + +
Sbjct: 1972 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2031
Query: 2380 PIQAQ-VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQA 2437
Q + + ++ +L + + R + + W Q L + A ++++ L+A
Sbjct: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
Query: 2438 QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARST 2497
+K++ + A + + + + LEE + + D++ S+S A++
Sbjct: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151
Query: 2498 GQQLL----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
QL A +P++ + LE+ +L+ +E +L+LQ+
Sbjct: 2152 FNQLAELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2200
Score = 422 bits (1086), Expect = e-117
Identities = 401/1847 (21%), Positives = 806/1847 (43%), Gaps = 94/1847 (5%)
Query: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714
+G +V E +QER ++ L +EL+ R ++LE + R F R+AE+L+ W+ +
Sbjct: 4 SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63
Query: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774
Q A + +DP + K F+ +V+ S + ++ GH A +R
Sbjct: 64 LQIAS--DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121
Query: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833
R +L W L E + +G L + ++ R+ +V+ + +K A + +DL
Sbjct: 122 TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181
Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
+E + + + ++ E ++ E+ + A ++ + P+ ++ +Q V AW L
Sbjct: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-QHPEEELIKTKQDEVNAAWQRL 240
Query: 1894 QRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWL 1953
+ QR+ +L A + RF V + SW Q + ++ ++ +S L H+ L
Sbjct: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
Query: 1954 RAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
+L A E L +A +L Q L+A ++Q + L +Q+ A + R
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHAR 356
Query: 2010 LQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK 2069
L + Q FL + L + + + L S V E L+ +H+ + A +
Sbjct: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
Query: 2070 EAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAA 2123
+ E + L VR++L +L + R + EL E R + + F +
Sbjct: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
Query: 2124 TQAEDWIQAW-AQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSVAKKGEALL 2181
Q ++W+ A L E + GD D ++ LLK H+ FE + A EE +T++ + L+
Sbjct: 477 EQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
Query: 2182 AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV 2241
+H +V+ R L L + R +L D + +F + D ++W+ EK +
Sbjct: 535 QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK-M 593
Query: 2242 KMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301
K + +D + L+ ++++ + A + + I ++ +L + + +
Sbjct: 594 KTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVA 650
Query: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361
R +++ + W +L A + +R ++++ + E E + + D GKDL
Sbjct: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
Query: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421
+VQ L +KH LE +V Q +++ + + + A ++ +Q+ + + L+
Sbjct: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
Query: 2422 SRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
R++ L D+L Q + + E ++ T+ + + + +L++HQ
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQAL 829
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQA 2540
+AE+ I G ++ GH + D++ L L Q+ +L+ + + L+ +
Sbjct: 830 QAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
Query: 2541 LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISAL 2600
L+ Q + + + E W+ KE + S E LL KH+ L DL I AL
Sbjct: 890 LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL 949
Query: 2601 EATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEV 2659
A+ Q P + ++ A+ +E R+ ++ + L L + +D +V
Sbjct: 950 REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWKV 1007
Query: 2660 AAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA 2719
R+ + A LD PAQ ++N E + +Q+++ + + + G
Sbjct: 1008 EVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG--- 1060
Query: 2720 SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPT 2779
++ R++++ L+ L + +K+ L+K+C+ L R EL+ W+ E L +
Sbjct: 1061 --SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
Query: 2780 VGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLAQ 2827
VG L V L Q++L+A ++K A ++E L+ + V++
Sbjct: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
Query: 2828 DVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLKF 2863
++ + L +R++SL++ +ER L + + +F
Sbjct: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRF 1238
Query: 2864 FRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYK 2923
RDADE W++EK +YG L++V+ LQ +H+ E ++++ + T +
Sbjct: 1239 HRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAER 1298
Query: 2924 LVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAER 2983
L+Q+ +A ++ + +L +A + L A +R+ L + + Q+FL++ + SW+
Sbjct: 1299 LIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGI 1358
Query: 2984 GHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLA 3043
++ S+++ +ALL R + + +++A + + +Q L + + SP++
Sbjct: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
Query: 3044 QLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLE 3103
+L + + A+L + R L + L+L R+ + W+ + A ++D G L+
Sbjct: 1419 KLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLD 1478
Query: 3104 GVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD 3163
V+ L +K + F K + ++ + K+ AL+ A L I ++R+ + W RL
Sbjct: 1479 SVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537
Query: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED----GGHSLSSVRTLQQQH 3219
+ + L + + F + E++ + EK E LS + + Q+H
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKH 1597
Query: 3220 RRLERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQER 3271
+ E EL A + + ++ AC + A LA + + W L K+ E+
Sbjct: 1598 QAFEAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEK 1655
Query: 3272 GQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
Q L +A + F ++ W E + L +SE+ +D+A LL +H+ L +I
Sbjct: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ +DL + L+ +S F +++V + + GR Q+++ A R + ES L +
Sbjct: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
+ ++ E+W+ + L+ DYG ++ V+ L +H+ LE LAA E
Sbjct: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
Score = 308 bits (790), Expect = 5e-83
Identities = 458/2331 (19%), Positives = 897/2331 (38%), Gaps = 223/2331 (9%)
Query: 263 LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320
LLQ Q+ QY + D++ WI +K+ + + + L + L F F+T
Sbjct: 145 LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200
Query: 321 KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380
R+ + A L + Q H L + Q W + + ALQ
Sbjct: 201 HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246
Query: 381 QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437
++ E +RF S++K+ EQ++ D R LA+V+A +++ L
Sbjct: 247 RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
E + E + +AL AD L+Q S + ++EE+ W+++ + ++ D
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
+ L + + + E++ + +A LL RH + ++ AH
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 558 AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617
+ L ++ + + ++ K L++ + +L+ L RR EQ + F R+ E+ +
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 618 AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677
W+ + + N LG L + L+KH+ E + + L L
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 678 QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736
D R +A+ L R + R A+L + + Q+F D+ E SW+ E+ +++ + A
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796
+D + + +++H E L A + + LE+ G+ L VN
Sbjct: 601 Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642
Query: 797 RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856
+ + + + + ++ L +L+ +
Sbjct: 643 -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673
Query: 857 LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914
L EA F + +++LWL + L D V L+ ++ L +A +
Sbjct: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
Query: 915 WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974
++ A Q + ++ I+++QE L R+ L+ + +LA S+ + ++
Sbjct: 734 IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
Query: 975 GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
+ +R+ + G ++ Q Q + E R+ + + E
Sbjct: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
G+ ++ ++ ++ L + ++ + +QR + ++ Q + ++ + W + +
Sbjct: 854 GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913
Query: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
S + D SA+ LL++H+ L+ ++ + +Q L Q+Q P E
Sbjct: 914 GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967
Query: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207
G+EL + Q+ + ++K D T + ++ W + D G
Sbjct: 968 ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265
+ L + R LL G + ALR A +V +++ ++ + L
Sbjct: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
Query: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320
E+R+ L S + ++ EL QW+ EK E GA ++ L++
Sbjct: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137
Query: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357
+A ES L + E L+ G +E+ P + D +T
Sbjct: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197
Query: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408
++ L +W +L + ER L A + ++ R + KE +E+ AL
Sbjct: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257
Query: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467
+ G DL S Q LQ++H+ E + L K+ +L A + S P E+ Q+ L
Sbjct: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317
Query: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
L R Q +A S +L +F +SW+ S + + GA++L
Sbjct: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377
Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
+H+E + E+ A G Q G+ L A GH + I ++ L+ A+LE+A R
Sbjct: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
Query: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
L Q + Q + D + E W+ + +++ D G + LI KH+ + + +
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
Query: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701
+ L A L + + R + ++ R L+ + +L + L +F
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEH-----ALHLCTKFAKFQHQVEMGSQRVAACR 1756
R+ ++++ W++ + Q A + +DP + L K F+ ++ + R+
Sbjct: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
Query: 1757 LLAESLLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEV 1814
+ SL+ERG AG V+ R L W L + + + L++ + + +
Sbjct: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
Query: 1815 LTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPG 1873
+ E +A + +DL + L+ HQ LE ++ E +L++L A +
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSA 1734
Query: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933
V+ ++ + + ++ RRA+L + L +F + D SW + +
Sbjct: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGS 1794
Query: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993
E+ ++ + H+ L AEL A E Q G++ +E+Q+ L
Sbjct: 1795 EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1854
Query: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053
+ ++ Q A + +RL+ + Q F+ E + + + + G ++ ++ L+
Sbjct: 1855 EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1914
Query: 2054 RKHEVFLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRG 2107
+KHE F T +D+ +++ + ++ L + +++ A R
Sbjct: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-H 2166
L + F A E WI LK DL L K + F+A +QA
Sbjct: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN----- 2221
+E + ++ + LLA H ++ + R L K W L A R ++L + ++
Sbjct: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
Query: 2222 ---FLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
FL F ++ +W + E + LE LR FR + + A
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQAD 2151
Query: 2279 IRSISDLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLR 2320
+++L Q+K+ +P EE KII +R +L N
Sbjct: 2152 FNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKL 2211
Query: 2321 YQQQLEGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
Q+ + A H +E L + + ++E L L+ K RKH+
Sbjct: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ---- 2258
Query: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALH 2435
E+ +++Q++ +E ++G + + + H +A+ W QL + + L+
Sbjct: 2259 EIRAMRSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
Query: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486
QA+ + +E L + D + R HQE K+ L S
Sbjct: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2359
Score = 289 bits (740), Expect = 3e-77
Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)
Query: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
+ELS+L + +L+ + Q F E++E+W+ K + E DP ++ L
Sbjct: 30 KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82
Query: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
KH+ E +++ +G I L+ T + GH +++ R + + E L + +
Sbjct: 83 QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142
Query: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699
+L + ++L +L++ ++V W+ +K + E L LQK+ + FQ ++ A
Sbjct: 143 IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202
Query: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759
+ E+ + +L+Q HP E I+ + +E+ A W L+ + ++ KL A E R R
Sbjct: 203 ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262
Query: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815
++E +W++ E + + G+ L V LL G +R+L A DK +AL +A
Sbjct: 263 DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318
Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875
+ A ++ + L+ ++ +R ER L L +F D + +WV
Sbjct: 319 DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378
Query: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
E L A + ++ L ++HQ + E+ +HE + +G L+ AGH+A+ EV
Sbjct: 379 EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
Query: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995
++ L + A L RR +Q + Q F + + +W++++ L +ED+G S
Sbjct: 439 REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
Query: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055
++ +ALL++ E ++ L A +I L + A L + V + A+ L
Sbjct: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
Query: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115
RA R L + L Q R++ L +W+ K TA + Y +D ++ +K AF
Sbjct: 559 HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617
Query: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175
E+ S Q+++ AL K L + A+ + + + W++L +A + + L
Sbjct: 618 EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
Query: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235
A++ F + +++ + E + +D G L++V+ LQ++H LE ++ A + +
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
Query: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
+ +A + + K QEA + L+ R Q LA + + ++
Sbjct: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
W +E++ +A+S +D+ G + LL +H+ L EI + + + Q+G +V+ HF
Sbjct: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
Query: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
+ +V L EL + + L+ + R Q +S Q+ +AE+W+ E ++
Sbjct: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
Query: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464
DYG E LL +H+ L L+A +++ + P + + G+
Sbjct: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Score = 268 bits (684), Expect = 1e-70
Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)
Query: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674
A+ R Q +L R + RR +LE+ + Q F +D++E+ W++EK +A +E
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
D L +LQK Q F+AE+ A+ +L G ++ GH ASE I+ RL EL W
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
L + ++K KL +A + ++ R E++ +W+ E + + +GQ L V L
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851
E + + + + A ++E H L + +++ QR K L +R+
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248
Query: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
L + + +F RD DE ++W++EK L A+ D+G+ L++V+ L +H+ LE ++++ E
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ + +L Q+ +A ++ + ++L +R AA R L + Q+FL
Sbjct: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
Query: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031
+ + SW+ E +++++++ +ALL R + K +++A + ++ L
Sbjct: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
Query: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091
+ + S +V +L + E A LL E R ++ + L R+T +D W++ + A
Sbjct: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
Query: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151
++D G L+ V+ L +K + F K + S + K+ AL + A L + + +
Sbjct: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547
Query: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
R + + L + R LA + + F + + EL+ + EK ++ S+
Sbjct: 548 RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606
Query: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267
++ Q+H+ E EL A + + L+ +L ++ A +A +V W L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327
+ +G L +A Q F +++ W E + +S++ +D+ + L +H L +
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387
+ + + + + +Q D HF + + + + L R + L+E R Q+ A+S L
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
Q+L + +E E W+ E + + G + V+ LL +HQ L+ +A E +
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
Score = 223 bits (569), Expect = 2e-57
Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
A ++ R QQ+ + + RR L+ + Q F + E W+ E+ + E+
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
Q L++ +A + +++A S I +L +T L+ S + S + +L +
Sbjct: 72 YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
LL + +G L + +L Q RE + W+ K A S++ GQDLE V+VL++K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
F+ F+ ++ + + +V + + A L + I+ ++ + AAW+RL R
Sbjct: 191 FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
L A EV F + E ++EK LM +D G L+SV+ L ++H LER+L A+E
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287
+V L EA RL Q HP + + +E W ++ A ER L + + FL
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
++L +W E + L +++ELA DVAGAE LL +H+E EI + + GQ L+
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407
H+ S EV E L L L E W LR Q+ + LQ + EQ + W++ E
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
LL D G S+ VE LL +H+D EK L+AQEEK + +
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
Score = 127 bits (320), Expect = 2e-28
Identities = 137/569 (24%), Positives = 246/569 (43%), Gaps = 34/569 (5%)
Query: 206 AFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQ 265
A V E+++ Q + +AA + I + + RL + Q +++R +
Sbjct: 1493 AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL-KAQMIEKRS-----K 1546
Query: 266 LQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRL 325
L E++ LQ Q+ + V ++ WI+EK + D P QL + +
Sbjct: 1547 LGESQTLQ-QFSRDVDEIEAWISEKLQTASDESYKD--PTNIQLSKLLS---------KH 1594
Query: 326 QQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ---QR 382
Q+ A EA L ++ + G L E C AG E A AR AL Q
Sbjct: 1595 QKHQAFEAELHANADRIRG------VIDMGNSLIERGAC-AGSEDAVKARLAALADQWQF 1647
Query: 383 LLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS------LATVEAAVQRLGM 436
L+Q ++ + +K + +KD + L + A AS LA+V +++ +
Sbjct: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1707
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
LEA I E R + L AD L + V +++ + R+Q++ +R ++ +
Sbjct: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
Query: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556
+ ++++ ++E + S G+ L V L ++H LEA+++AH +
Sbjct: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
Query: 557 LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
+ +L E +Q + + + L L AR LE++L+ +F+ N EEE
Sbjct: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
Query: 617 EAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPP 676
EAW+ E V + G L+ I G L+KH+A E + H+ D+ G+DL +
Sbjct: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
Query: 677 TQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA 736
+ + + + + G L+ R A+L LQ+ A SW+ E+ +SL+
Sbjct: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
Query: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAE 765
G+D ++ +TLL + + L+AF E
Sbjct: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQE 2036
Score = 123 bits (309), Expect = 3e-27
Identities = 211/1120 (18%), Positives = 440/1120 (39%), Gaps = 125/1120 (11%)
Query: 376 SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426
++ LQ++ +L Q +L +R Q KA L +S FL D ++ +++
Sbjct: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
Query: 427 -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479
EA ++R I + G FQA + L +++ ++ +++ ++ +
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425
Query: 480 WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
+ L+ QR+ + D L L ++ E A + + + + G L V L++
Sbjct: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485
Query: 539 RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
+H+ + ++ ++ L +L ++ + + ++ + + L A + +R+
Sbjct: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545
Query: 599 LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL----GRDLSQIAGALQKHKALEAEVH 654
L ++ +F R+ +E EAW+ E Q + + LS++ QKH+A EAE+H
Sbjct: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
Query: 655 RHQAVCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLV 712
+ ++ G L R + +A A+ WQ L + + +L+ A
Sbjct: 1606 ANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ 1665
Query: 713 LQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
+ + WL E + L G+D A+ LL++H LE + A L+ L Q
Sbjct: 1666 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
Query: 773 GRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTI 832
SL T ++ FD + +
Sbjct: 1726 AD------SLMTSSA---------------------------------------FDTSQV 1740
Query: 833 LQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD 892
+D ++ ++ ++++A RRA+L E+ L F + + W++++ +L+ D
Sbjct: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
Query: 893 TLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQL 950
V L K++ LA + V + ++L +IQ++ + + W +L
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
Query: 951 EALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT 1010
+ L + +L S+E F+ + + + + + + G DT A+Q KK
Sbjct: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKH 1917
Query: 1011 LVLER-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQ 1063
E RV+ + + + + + + +++ L G + +++ AQR +
Sbjct: 1918 EAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKL 1977
Query: 1064 AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QER 1122
E A F ++ + W + L++ + D++S Q LL + + + + QE
Sbjct: 1978 DENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
Query: 1123 LQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREV 1182
+ + A + A S+ + L ++ +L R++ L LE Q R+V
Sbjct: 2038 IANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKV 2094
Query: 1183 DGFTATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEA 1231
+ T A + + +N ED + E +L + H F LS+
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
Query: 1232 LRAHGEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQL 1281
L A ++ ++S A++ +++++ W LQ + EQRR++ L+
Sbjct: 2155 L-AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR- 2212
Query: 1282 QEWKQDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
QE+ Q QW++E E SG + L+ KR E+ A R ++
Sbjct: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKK 2269
Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
++ +G + + + GL +W+ L++ L+Q Q ++A
Sbjct: 2270 IEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA 2329
Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436
++ + ++G + HQ+ +S R+L
Sbjct: 2330 LKEFSMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2360
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 567 bits (1462), Expect = e-161
Identities = 512/2247 (22%), Positives = 965/2247 (42%), Gaps = 112/2247 (4%)
Query: 1156 QELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQH 1215
Q K +R Q L++ LQ F R+ D + + D ED Q+H
Sbjct: 36 QSFKERVAERGQKLEDSYHLQVFKRDADDL-GKWIMEKVNILTDKSYEDPTNIQGKYQKH 94
Query: 1216 REFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL 1275
+ + T L E+ H A + ++ ++ W L + ++ QL
Sbjct: 95 QSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQL 154
Query: 1276 LASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHV 1334
L +L+ Q++ Q+ A++++W+ +K +A G + L K+ E + EL+A V
Sbjct: 155 LRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRV 214
Query: 1335 EALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQ 1394
+ Q E IQ++ + + WE L +R L A ++ R +
Sbjct: 215 VEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVT 274
Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS- 1453
+A + +++ E L S + G+DL +S+ L H+ LE ++ K+ L + A + S
Sbjct: 275 EAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH 334
Query: 1454 ----PAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGS 1509
P I E + + E ++ R +LQA+ H+F + W+ E +
Sbjct: 335 PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAIN 394
Query: 1510 PTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQEL 1569
+ G + L +H++ + E+ ++ + Q +G+ L + H + + E+ + L
Sbjct: 395 ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEIL 454
Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRL 1629
+ +W L + R + +Q + F ++ D +++ W+ + + + D G + L
Sbjct: 455 DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEAL 514
Query: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV--VQERLREQLRALQELAATR 1687
+ KH+ +E + +D+TA L G + + + + +++ L + AL+E AATR
Sbjct: 515 LQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
R L+ +L L + +++DL+ W+ +K+ A + +D ++ K F+ ++ +
Sbjct: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY--KDIQNLKSRVQKQQVFEKELAV 632
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
++ + + ++E GH A V R ++ + W EL E T+ +G L + L+
Sbjct: 633 NKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF 692
Query: 1808 HR---DLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETA 1864
DL L V+ + TS + + L ++ +LR H LE + + Q+ L + A
Sbjct: 693 ENNAEDLQRWLEDVEWQVTS--EDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLA 750
Query: 1865 GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWA 1924
+++ P + ++ RQ+++ + L+ + R+ +L L D +W
Sbjct: 751 AYFEEI-GHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWI 809
Query: 1925 ARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE 1984
++ + L+ H+ + + + E Q+ T+ G + + ++
Sbjct: 810 QETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAED 869
Query: 1985 VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGS 2044
V +++L + + AR+Q L+A Q Q +L + E + +E + + G+
Sbjct: 870 VASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGA 929
Query: 2045 SVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
E L++KHE FL L + ALR + ++ + + ++R+ +
Sbjct: 930 DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQ 989
Query: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
+R T ++ +DW + A + VP +R L H F Q
Sbjct: 990 ARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRR-----LAHDEFPMLPQ 1044
Query: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN-FL 2223
E G ++QR + + + L R + L R N FL
Sbjct: 1045 RRRE------------------EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFL 1086
Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
+ D+ E WIQEK+ + + G +L+ +L+++ EF+ + + I ++
Sbjct: 1087 LAYEAGDMLE-WIQEKKAE----NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVA 1141
Query: 2284 DLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTK 2343
D L PE +I R +LN+RW S +Q L A + V RE D+ +
Sbjct: 1142 DDLLFEGLLTPEGAQI----RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKE 1197
Query: 2344 RIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
+I++K + A D G DL SVQ L R+HE ER++ P+ +V L RL + P+A
Sbjct: 1198 QIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDAT 1257
Query: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDA-------LHQAQKLQAMLQEL--LVSAQRL 2454
L+ ++ E+ E+W L+ R + R+E+L+ L +A+ LQ + + +VS+Q L
Sbjct: 1258 EDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQEL 1317
Query: 2455 RAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQ 2514
+ + +E +LE HQE +A++++ + +L+ +GH S +I +
Sbjct: 1318 AEDL-------TGIEI--LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEK 1368
Query: 2515 VLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLA 2574
L ++ E LE AW++ + L Q LELQ+F + +++E W+ ++E+SL S+ L
Sbjct: 1369 KLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLD 1427
Query: 2575 PMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
+E L+ K L+ + Q GKI+ LE A L H + R Q +L R +AL
Sbjct: 1428 SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKA 1487
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAE 2694
Q R +L + L+ F +D +E+ W+ E A +E D + + K Q F E
Sbjct: 1488 QLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHE 1547
Query: 2695 LDASMHQQQELQREGQRLLQGG--HPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
+D Q + G L++ EA++E+LE+L W L + + K KL +A
Sbjct: 1548 VDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEAS 1607
Query: 2753 EALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALL 2812
R S+ + E WL E L + L G LL + LE + + + L
Sbjct: 1608 RQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLN 1667
Query: 2813 GQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
A+ + G + ++ + +RF +++E L+ L +FF+D D+E +
Sbjct: 1668 TLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES 1727
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
W++EKL ++QDYG+ L V++L ++H+ LE E+ +HE + VL KL
Sbjct: 1728 WIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ 1787
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
E+ R+ Q + L+ A R L L+++ E QF+ E +W+ E+ + D
Sbjct: 1788 EEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDC 1847
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERL-QQTAALLES--RKNPESPKVLAQLQAVR 3049
G + ATQ+LL + EA + D R++ + Q +L ++ ++ ++ ++++A+
Sbjct: 1848 GDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN 1907
Query: 3050 EAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLE 3109
E L + A L++ + + +++AW+ K + ++ G DL L
Sbjct: 1908 EKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLL 1967
Query: 3110 EKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKAR 3169
K D +QS Q ++ + L L + I+ + + + WE+L +A
Sbjct: 1968 AKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVH 2027
Query: 3170 TENLAA---------------AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRT 3214
+ L AH+ + +++ + E + SL+ +R
Sbjct: 2028 RQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCV-------SLNEIRQ 2080
Query: 3215 LQQQHRRLEREL---EAMEKEVARLQTEACRLGQLHPAAPGGLAKV---QEAWATLQAKA 3268
LQ+ H L +A K + L + LG P++P V + W L
Sbjct: 2081 LQKDHEDFLASLARAQADFKCLLELDQQIKALGV--PSSPYTWLTVEVLERTWKHLSDII 2138
Query: 3269 QERGQWL-AQAAQGHAFLGRCQE-------LLAWAQERQELASSEELAEDVAGAEQLLGQ 3320
+ER Q L + A+ CQE L W E + L ++ E L
Sbjct: 2139 EEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEA 2198
Query: 3321 HEELGQEIRECRLQAQDLRQEGQQLVD 3347
++ +EI+ + Q + G L D
Sbjct: 2199 NKRKQKEIQAMKRQLTKIVDLGDNLED 2225
Score = 556 bits (1433), Expect = e-157
Identities = 400/1444 (27%), Positives = 684/1444 (47%), Gaps = 96/1444 (6%)
Query: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL--KEPVP 2142
+++R +L R KE RG L S + F + A WI L K
Sbjct: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYED 83
Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
P +++ K + KHQ+ EAEVQ +M+ + K E H E ++ LR W
Sbjct: 84 PTNIQGKYQ---KHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
Query: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
+ L + +G +L F +++Q WI +KE +LG+D E L ++
Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
Query: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
+F+ + + ++ + + + ++ +I +++++N W G L+ Q
Sbjct: 201 EDFQVELVAK---EGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
Query: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
+ L A + R++ + I+EKE ++ + D GKDL + + L H+ LER + +
Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMS 317
Query: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
+V+ L + +L P A ++ ++++ SW +R+ A R E L A + + +
Sbjct: 318 DKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377
Query: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
EL A ++ P +L+ HQ+ K E+DS+ D A TGQ L+
Sbjct: 378 DFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLV 437
Query: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
A H S ++R+ + L+ ++L W E Q +Q L+ LF E+++ W+ +E
Sbjct: 438 NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
Query: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
L +E L + L E LL KH+ E Q KI ++ TA L H ++++
Sbjct: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
Query: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
+L R++AL +A TRR L+E LQ +DS ++ W+ +K +A +E D L
Sbjct: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
Query: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
+++QKQQ F+ EL + Q + +Q+ GQ +++GGH AS+ + RL E+ +LW EL + ++
Sbjct: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
Query: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
+K +L +A + L+ + E+L+ WLE +E ++ + G+ L V L LE+AV
Sbjct: 678 QKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVA 737
Query: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
+ Q + L A F GH ++D+ + L+ RF++L+EPL R+ L L
Sbjct: 738 ARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQL 797
Query: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
RD ++E AW+QE P A + G+ L A + L +H+ + ++SHE + + G
Sbjct: 798 ICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
K+V+ GHFAA +VA+RV+ L + M LRA AARR+ L+ + QQ+L +L EA +W+ E
Sbjct: 858 KMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE 917
Query: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERL--------QQTAALLESRK 3034
+ ++D+ + G EA ALL++ EA DL +F ++ L QQ AA +E
Sbjct: 918 KEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVA 977
Query: 3035 NPE-----------SPK--------VLAQLQAV----------------------REAHA 3053
+ SP+ VL L ++ R AH
Sbjct: 978 GEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHD 1037
Query: 3054 EL----LRRAEARGHGLQEQLQLHQL---------ERETLLLD---------------AW 3085
E RR E G+ Q Q Q+ ER LL W
Sbjct: 1038 EFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEW 1097
Query: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
+ K A ++ G +L+ V L++KFD F+K++ + + ++ + K+A L
Sbjct: 1098 IQEKKA----ENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDL-LFEGLLT 1151
Query: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDG 3205
P R + + W L + + + L +AH V F + A + + ++++K + D
Sbjct: 1152 PEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
Query: 3206 GHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK----VQEAW 3261
G L SV+ LQ++H ER+L + +V L A RL + HP A L + + EAW
Sbjct: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
Query: 3262 ATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQH 3321
LQ + ++R + L +A + + FL + ++L W + SS+ELAED+ G E LL +H
Sbjct: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
Query: 3322 EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRC 3381
+E ++ Q L +L+D+ H S E+ + LQ ++ +LE+AW R +
Sbjct: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
Query: 3382 AESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKF 3441
+ LQ + +Q E+W+ E L+ D S+ +E L+ + DL+K + AQE K
Sbjct: 1392 DQCLELQMFQGNCDQVESWMVAREN-SLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKI 1450
Query: 3442 AQMQ 3445
++
Sbjct: 1451 TDLE 1454
Score = 448 bits (1153), Expect = e-125
Identities = 492/2299 (21%), Positives = 941/2299 (40%), Gaps = 217/2299 (9%)
Query: 683 ERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
ER + V +Q + RV RG +L+ + + + DA + W+ E+ + L S +D
Sbjct: 26 ERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-EDP 84
Query: 743 AAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPW 802
+ ++H LE ++ + + LE+ R FT+ +
Sbjct: 85 TNIQGKYQKHQSLEAEVQTKSRLMSELEK------TREERFTMGHSAH------------ 126
Query: 803 SEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMA 862
E H ++ HL ++ L L + +L A+
Sbjct: 127 EETKAH------------------------IEELRHL---WDLLLELTLEKGDQLLRALK 159
Query: 863 LFGFCSSCGELQLWLEKQTVLLQRVQPQAD--TLEVMQLKYENFLTALAVGKGLWAEVSS 920
+ C ++ W+ + + V+ D EV+ K+E+F L +G EV+
Sbjct: 160 FQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ 219
Query: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
A + + + IQ +Q E++ W +L L ++ L+++ + F ++
Sbjct: 220 YANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQW 279
Query: 981 LRDVLLQLEALQPG----SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
+++ L + G +SE H+ + ++ V+ +V L + K+ +++
Sbjct: 280 IKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAP 339
Query: 1037 PLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVS 1096
+Q E L + ++ R + T F + +L W A + + E+
Sbjct: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELP 399
Query: 1097 VDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
DVA + LL HQ EI + +R Q D Q + + S EV + +L
Sbjct: 400 TDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWT 459
Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHR 1216
L LW++R + ++ L+ F R+ + + + +A+L ++LG + A +LLQ+H
Sbjct: 460 ALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
+F + + + KL+ H + ++ + A+ L+ ++ RRR L
Sbjct: 520 DFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLK 579
Query: 1277 ASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
SL LQ+ +D +L W+ +K +A E +N+ +++ + E EL + +E
Sbjct: 580 ESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLEN 639
Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
+Q+ G+E++ +++ TRL + S WE L ++G +L +A QQ Q +D
Sbjct: 640 IQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDL 699
Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAH-----GMA 1451
+ LE +E + S + G+ L Q ++H LES ++ L +A G
Sbjct: 700 QRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP 759
Query: 1452 ASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
S I + + R E L+ LA R +L + L C + E +W+ E P + T
Sbjct: 760 DSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATST 819
Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
+ L ++ L +H+ + + +H+ ++Q + G + GH A+ + + + L
Sbjct: 820 YLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
+ L R L+ V FQQY D+ E E W+ EK P+V + +YG DE A L+
Sbjct: 880 NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLK 939
Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL 1691
KH+A +L + SM+ L A + + V E +++ AL + A RE+
Sbjct: 940 KHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGE---QRVMALYDFQARSPREV 996
Query: 1692 EGTLRLHEFLR------------EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
T++ + L EA D QG + + + P+
Sbjct: 997 --TMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNIT 1054
Query: 1740 KFQHQVEMGSQRVA-ACRLLAESLLER------GHSAGPMV----RQRQQDLQTAWSELW 1788
+ Q Q+E + + LL+R + AG M+ ++ ++ ++W
Sbjct: 1055 QRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVW 1114
Query: 1789 ELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLER 1848
EL + +D T RD+ +V + + P + +L S G +
Sbjct: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ-----IRQELNSRWGSLQ 1169
Query: 1849 ELVGTERQL-----------QELLETAGRVQKLC-------PGPQAHAVQ---------- 1880
L +RQL +E +T +++K C PG +VQ
Sbjct: 1170 RLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE 1229
Query: 1881 -------------------------------QRQQ-AVTQAWAVLQRRMEQRRAQLERAR 1908
QRQ+ + +AW LQ R + R+ L A+
Sbjct: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289
Query: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
F + RD +W + + + +E +++ + + L HQ RA++EA +Q
Sbjct: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
Query: 1969 QLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE 2028
+ + + + E++++L+A++ +RD + + W ++++ L + Q+F C ++E
Sbjct: 1350 DFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVES 1409
Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------RR 2082
+ A+E SL++ SS++ +E L++K + K +TAQ+ K L ++L +
Sbjct: 1410 WMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAK 1468
Query: 2083 PRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
+ RL +L R +K L + F + + E+WI E +P
Sbjct: 1469 EEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWI-------SEMLP 1521
Query: 2143 PG------DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE--VSQR 2194
D + + LKHQ F EV E + V G +L+ S E + ++
Sbjct: 1522 TACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581
Query: 2195 LQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEH 2254
L+ L++HW+ L + +G++L + F + E W+ E E + + D +DL
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641
Query: 2255 CLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASF 2314
L L++ + + ++ ++ L+ L + V I +++ +N R+ +
Sbjct: 1642 AGNL---LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNV 1698
Query: 2315 HGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL 2374
+ ++L+ A + ++LD+ I+EK + + D G+DL+ VQ LL+KH+ L
Sbjct: 1699 QELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRL 1758
Query: 2375 EREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR------- 2427
E E+ + ++++ +L ++ ++ R + E W +L+ A+ R
Sbjct: 1759 EGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEES 1818
Query: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487
E L + A++ +A + E A R DT A +S +L +H+ + +
Sbjct: 1819 LEYLQFMQNAEEEEAWINEKNALAVRGDCG-DTLAATQS------LLMKHEALENDFAVH 1871
Query: 2488 TDSISLARSTGQQLLT---AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQ 2544
+ + G+ +L + +I + L ++ SL A +LQL+ Q
Sbjct: 1872 ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQ 1931
Query: 2545 LFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEAT 2603
F + +E W+ KE SL + G L LL K L+ L+ Q ++ +
Sbjct: 1932 EFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDL 1991
Query: 2604 ARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWL 2663
L H ++++ R A+L R E L + R +L E +QL LQ ++++
Sbjct: 1992 KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLE-KQLP--LQKAEDLFVEF 2048
Query: 2664 REKNLV------ALEEGLLDTAMLPA-----QLQK-QQNFQAELDASMHQQQELQREGQR 2711
K +EE L + + QLQK ++F A L + + L Q+
Sbjct: 2049 AHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQ 2108
Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPI 2771
+ G P+S +E L W L D +++ +LQK E R ++ E + + +
Sbjct: 2109 IKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK--EEARQVKNFEMCQEFEQNA 2166
Query: 2772 EVELRAPTVGQALPGVGELLGTQRELEAAVD---KKARQAEALLGQAQAFVREG----HC 2824
L+ +A G LL LE+ ++ +K ++ +A+ Q V G
Sbjct: 2167 STFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDA 2226
Query: 2825 LAQDVEEQARRLLQRFKSL 2843
L D++ L Q++ L
Sbjct: 2227 LILDIKYSTIGLAQQWDQL 2245
Score = 431 bits (1108), Expect = e-120
Identities = 420/1905 (22%), Positives = 814/1905 (42%), Gaps = 74/1905 (3%)
Query: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
A+ I E+ QE+ + + R Q L+ + Q + D +L W+ EK +++ +
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQT--LTGPEVPEQQRVVQERLREQ 1676
Y D KHQ+L+ E+ M EL++T + G E+ + E LR
Sbjct: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
Query: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
L EL + +L L+ ++++E D+ W+ ++ A E LGED E L
Sbjct: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVE-LGEDWERTEVLHK 198
Query: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
KF FQ ++ RV A E H P+++ +Q ++ AW L L R
Sbjct: 199 KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258
Query: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTER 1855
AL + R RD+ E + ++EK L + + +DL E SH+GLER L
Sbjct: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318
Query: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
+++EL A ++ P A +Q+ ++ + +W ++ R +L+ RF +
Sbjct: 319 KVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377
Query: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
+ + W + +E + + G + L HQ + E+++ + +Q A + GQ +
Sbjct: 378 DFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLV 437
Query: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
A + EV+E++ L + + + W + + + LF R+ +++ ++ QE
Sbjct: 438 NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
Query: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPI---- 2091
L+ LG+S+ E L++KHE F + TAQ++K + + L D I
Sbjct: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
Query: 2092 --LLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDK 2149
LL RR ++E A +R L SLL+ + + ++WI ++L + D+++
Sbjct: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNL 616
Query: 2150 LKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM 2209
+ K Q FE E+ ++ + ++ K G+ ++ H + V+ RL + WE+L +A
Sbjct: 617 KSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676
Query: 2210 ALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNS 2269
+G +L + L+F + + W+++ E ++ D G+ L +++ RLR+
Sbjct: 677 KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA---EVQNRLRKHGLLE 733
Query: 2270 AGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL 2329
+ + ++DL+ + + K I R+ L R+ + L +++L L
Sbjct: 734 SAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLL 793
Query: 2330 EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLE 2389
+ ++ R+ ++ IQE E + GKDL + ++LL +H + + + +++ +
Sbjct: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
Query: 2390 REVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449
++ + AA + R + + ++ LR+RA +R+ L+A Q Q+ A L E
Sbjct: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
Query: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFS 2509
+ +D + A +L++H+ +L+S+ DS+ R+
Sbjct: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN------------- 960
Query: 2510 SDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGL 2569
Q A +Q+ + +EG E ++ + L+ K D L
Sbjct: 961 ----QANACQQQQAAPVEGVAGEQRV-------MALYDFQARSPREVTMKKGDVLTL--- 1006
Query: 2570 WDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARG-LHQGGHPEAQSALGRCQAMLLR 2628
L+ + WK + + V A + L L Q E + R + + +
Sbjct: 1007 ---LSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ 1063
Query: 2629 KEALFRQAGTRRHRLEELRQLQAFL--QDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQ 2686
+L +A RR RL L++ FL ++ ++ W++EK L D L +
Sbjct: 1064 YRSLLDRAEERRRRL--LQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQ---K 1118
Query: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVA 2746
K FQ +L+ + + +++ + LL G E Q R +EL + WG LQ + ++
Sbjct: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNSRWGSLQRLADEQRQ 1177
Query: 2747 KLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVD 2802
L A R ++ + +E L A G L V L G +R+L D
Sbjct: 1178 LLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237
Query: 2803 KKARQAEALLGQAQAFVREGHCLA-QDVEEQARRLLQRFKSLREPLQERRTALEARSLLL 2861
K +LG+ + E H A +D++ Q L + ++ L+ ++R+ +L
Sbjct: 1238 KVT-----ILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFY 1292
Query: 2862 KFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTG 2921
F A + W+ + ++Q+ + L+ + L E+HQ ++M + + +
Sbjct: 1293 LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFS 1352
Query: 2922 YKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLA 2981
+L+ +GH A+ E+ ++Q ++ L +R+ +L Q E Q F + SW+
Sbjct: 1353 AELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMV 1412
Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
R + L S+D S ++ +AL+++ + + + A +I L+ A L + ++ ++
Sbjct: 1413 ARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI 1471
Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
+LQ V + L + L + L Q R+ L+ W++ TA + Y +D
Sbjct: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KD 1530
Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER--GAPRRYPHIQAQRSRIEAAW 3159
++ K F EV + +V+ + L +L ++ Q +++ W
Sbjct: 1531 ATNIQRKYLKHQTFAHEVDGRSE-QVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHW 1589
Query: 3160 ERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQH 3219
+ L + + + L A F + + + + E L+ +D L+S L ++H
Sbjct: 1590 DHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKH 1649
Query: 3220 RRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWL 3275
+ LERE+ A E + L T A L + K V + + +Q A + L
Sbjct: 1650 QLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
Query: 3276 AQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQA 3335
+A F + +W +E+ SS++ D+ G + LL +H+ L E+
Sbjct: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
Query: 3336 QDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLE 3395
Q++ ++L D + E+ L + ++L+E R + ES + Q E
Sbjct: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
Query: 3396 QAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
+ EAW+ L ++ D G +++ + LL +H+ LE A E +
Sbjct: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874
Score = 391 bits (1005), Expect = e-108
Identities = 375/1676 (22%), Positives = 707/1676 (42%), Gaps = 111/1676 (6%)
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
+ +++ VQ+ + E + + + + + + + + +++ +V R EV W+ L
Sbjct: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL 672
Query: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
L+ + + Q+ + L E LE+++ S G+ LAEV L++H LL
Sbjct: 673 LEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLL 732
Query: 544 EAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQT 603
E+ V+A V L A + + ++A+ +L ++L + R+ L
Sbjct: 733 ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792
Query: 604 LQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDL 663
L R+ E+EEAW++E + LG+DL L +H+ + + H+ ++
Sbjct: 793 LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
Query: 664 VRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAA 723
RG + D R +++ + L+ R R L+ + QY AD EA
Sbjct: 853 TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE 912
Query: 724 SWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ----------- 772
+W+RE+ ++ + G D+ AA LL++H L +F ++ L Q
Sbjct: 913 TWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP 972
Query: 773 --GRAASARASLFTVNSALSPPGESLR-----------NPGPWS-EASCHPGPGDAWKMA 818
G A R A SP +++ N W EA+ H G A +
Sbjct: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVR 1032
Query: 819 LPAEPDPDF-------DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCG 871
A + +P I Q Q+ + Y SL A+ RR RL + F G
Sbjct: 1033 RLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAG 1092
Query: 872 ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPG 931
++ W++++ + + D + +Q K++ F L + +++ A+ L + G
Sbjct: 1093 DMLEWIQEKKA--ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLL--FEG 1148
Query: 932 NSTQIQRQ-QEELSQRWGQLEALKREKAVQL--AHSVEVCSFLQECGPTQVQLRDVLLQL 988
T Q ++EL+ RWG L+ L E+ L AH+VEV F +E T+ Q+ L
Sbjct: 1149 LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEV--FHREADDTKEQIEKKCQAL 1206
Query: 989 EALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVET 1044
A PGS + ALQ ++ + L +V L ++ E ++ LQ Q
Sbjct: 1207 SAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266
Query: 1045 LQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQR 1104
L + +Q + R E Q FL +++ L W S+ + S+E++ D+ +
Sbjct: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
Query: 1105 LLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164
LL HQ+ ++ Q L+ S + S E+ L+ + + +L+ WE+
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
Query: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWL--HLDNLGEDVREAL----SLLQQHREF 1218
R++ L + LELQ F C ++W+ ++L D + +L +L+++ +
Sbjct: 1387 RKKILDQCLELQMF-------QGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDL 1439
Query: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
+ ++ + L E L+ +H A + +LQ + +W L+ + R +L
Sbjct: 1440 DKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDY 1499
Query: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQ 1338
L+++ +D+ EL +W+ E A E NI + +H+ E+ V +
Sbjct: 1500 ANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
Query: 1339 QVGRELLSRRPC--GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
+G L+ C +E ++ +L+ L+ W+ L + ++G +L +A +Q++ ++D
Sbjct: 1560 NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDF 1619
Query: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA- 1455
+ L + E L + +DL S+ L K+HQ LE E + L ++A + +S
Sbjct: 1620 EFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
Query: 1456 ----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
I+++ +R +Q A +L+ + L QF + E SW+ E + S
Sbjct: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSL---AASGHPQAQHIVEQCQE 1568
Y L G Q+L +KHK L+ E+ AH+ +Q VL L AA G + Q + Q E
Sbjct: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVE 1799
Query: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLR 1628
HW +L+ +AR L++++ + Q+ + E E W+ EK L D G AAT
Sbjct: 1800 ---HWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQS 1856
Query: 1629 LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ-----ERLREQLRALQEL 1683
L+ KH+AL+ + A++ + ++ + + + + E+ + + E L E+ +L +
Sbjct: 1857 LLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKA 1916
Query: 1684 AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQH 1743
A +LE EF +A+ ++ W+A ++ + K + G D L L K
Sbjct: 1917 IAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN-GADLGDFLTLLAKQDTLDA 1975
Query: 1744 QVEMGSQ-RVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE 1802
++ Q R+ L + L+ H+ + +R L W +L E + L + +
Sbjct: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035
Query: 1803 TTLRVHRDLLEVLTQVQEKATSLPN-------NVAR-----DLCGLEAQLRSHQGLEREL 1850
L+ DL + KA++L N N++ L + + H+ L
Sbjct: 2036 LPLQKAEDL---FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASL 2092
Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERA--- 1907
+ + LLE +++ L P + + + + W L +E+R +L++
Sbjct: 2093 ARAQADFKCLLELDQQIKAL-GVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151
Query: 1908 -----RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREK 1962
+ F + W R +E + +L A++ + E++A ++
Sbjct: 2152 QVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKR 2211
Query: 1963 LWQQATQLG---QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
+ LG + AL+ +++ L Q DQ+YQ R Q L+ + Q
Sbjct: 2212 QLTKIVDLGDNLEDALIL------DIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ 2261
Score = 357 bits (917), Expect = 9e-98
Identities = 471/2268 (20%), Positives = 900/2268 (39%), Gaps = 154/2268 (6%)
Query: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG 994
+IQ +++E+ R+ + E+ +L S + F ++ + ++ ++ L
Sbjct: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLG---KWIMEKVNILTDK 79
Query: 995 SSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP-------GYAESQPLQGQVETLQG 1047
S ED + +Q +K LE V ++ ++E+ G++ + + +E L+
Sbjct: 80 SYEDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
Query: 1048 LLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
L + E ++ + Q ++QE +L W +A S E+ D + L +
Sbjct: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
Query: 1108 EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
+ +D E+ + R+ +++ + A + PD + + + + L+ L QRQ+
Sbjct: 199 KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258
Query: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
L LQ+F R+V + L ++ G+D+ + L H+ R L+ +
Sbjct: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318
Query: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
+ + L A EKL S A ++E + + + W ++ + R +L A+ + D
Sbjct: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
Query: 1288 VAELMQWMEEK--GLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
EL WM EK + A P+ + L RH+ + E+ + ++ + G++L+
Sbjct: 379 FDELSGWMNEKTAAINADELPTDVAGGEV-LLDRHQQHKHEIDSYDDRFQSADETGQDLV 437
Query: 1346 SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEG 1405
+ ++++ +++ L + W AL ER + +Q R + + + E
Sbjct: 438 NANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
Query: 1406 ALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465
L++ + G L S++ L ++H+ E K+ + A + E K +R
Sbjct: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
Query: 1466 -----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGA 1520
R + L+ A R L+ S+ L + S+ +W+ + Y + N
Sbjct: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN-L 616
Query: 1521 QSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERAC 1580
+S +K + + E+ ++ Q++ + +G+ + GH + ++ + E+ W EL A
Sbjct: 617 KSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEAT 676
Query: 1581 EARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEEL 1640
+ + L +A Q+ + +L+ W+E+ V+S DYG+ A + KH L+ +
Sbjct: 677 KQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
Query: 1641 AIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEGTLRLH 1698
A ++ L A P+ + R QE L + AL+E ATR ++L L L
Sbjct: 737 AARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQ 796
Query: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
R+ ED + W+ + +A LG+D + L + + R+
Sbjct: 797 LICRDTEDEEAWIQETEPSAT-STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
Query: 1759 AESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQV 1818
++E GH A V R + L L R + L + DL E T +
Sbjct: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
Query: 1819 QEKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
+EK + N N D A L+ H+ +L ++ L QA+
Sbjct: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN------------QAN 963
Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESS 1937
A QQ+Q A + A QR M Q R + + D + + + +D E++
Sbjct: 964 ACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKK---GDVLTLLSSINKDWWKVEAA 1020
Query: 1938 QEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT---KEVQEELRALQD 1994
HQ + + R + L Q+ G T ++++ + R+L D
Sbjct: 1021 D-----------HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD 1069
Query: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
+ ++ ++ RL E L E G + E + + K G +++V +L +
Sbjct: 1070 RAEE-------RRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWELQK 1118
Query: 2055 KHEVFLKVLTAQDKK--------EAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
K + F K L + + + L E L T ++R L R ++ LA+ +
Sbjct: 1119 KFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELN---SRWGSLQRLADEQ 1175
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAH 2166
L ++ + F + A ++ I+ Q L P DL +H+ FE ++
Sbjct: 1176 RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPL 1235
Query: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQ-GLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
+ +T + + E L++SHP A E QR + L + WEDL+ R + L + + F F
Sbjct: 1236 GDKVTILGETAER-LSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLF 1294
Query: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
L + + WI ++ +L +DL L R +E R + + +++ D
Sbjct: 1295 LSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA---PTFQALEDF 1351
Query: 2286 SLQL----KNRDPE---EVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL 2338
S +L + PE +++ + R L W + ++ L+ LE+ +
Sbjct: 1352 SAELIDSGHHASPEIEKKLQAVKLERDDLEKAWE-------KRKKILDQCLELQMFQGNC 1404
Query: 2339 DNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQR 2398
D V + +E +++ D L+S++ L++K ++L++ + + ++ LE L
Sbjct: 1405 DQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIAD 1463
Query: 2399 SPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV-SAQRLRAQ 2457
A + R Q V + W L+++ R L ++ L+EL ++ L
Sbjct: 1464 EHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTA 1523
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL--TAGHPFSSDIRQV 2515
D S + ++ + + +HQ E+D ++ + + G L+ +A +++
Sbjct: 1524 CDESYKDATNIQRKYL--KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQ 1581
Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575
L L++ L + +L +A Q F +S+ E WL E LA + LA
Sbjct: 1582 LEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLAS 1641
Query: 2576 MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ 2635
LL KH++LE ++ + + L A L G + + + R +
Sbjct: 1642 AGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQEL 1701
Query: 2636 AGTRRHRLEELRQLQAFLQDSQEVAAWLREKNL-VALEEGLLDTAMLPAQLQKQQNFQAE 2694
A +L+E L F QD + +W+ EK + V+ ++ D + L+K + + E
Sbjct: 1702 AAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGE 1761
Query: 2695 LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEA 2754
L A Q + ++L E IQ RL + W +L++ ++ + KL+++ E
Sbjct: 1762 LVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEY 1821
Query: 2755 LRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL-------EAAVDKKARQ 2807
L+ ++ EE E W+ G L LL L E V Q
Sbjct: 1822 LQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQ 1881
Query: 2808 AEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA 2867
E +L + V + +++ + L ++ SL + + + LE +F A
Sbjct: 1882 GEDILNK----VLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKA 1937
Query: 2868 DEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS--HEALTRVVLGTGYKLV 2925
D AW+ +K G L L + L++ + S E L + KL+
Sbjct: 1938 DVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT-DLKDKLI 1996
Query: 2926 QAGHFAAHEVAARVQQLEKAMAH-LRAEAARRRLLLQQ---AQEAQQFLTELLEAGSWLA 2981
A H + + R L K L A A R+ LL++ Q+A+ E S L
Sbjct: 1997 SAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALN 2056
Query: 2982 ERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQ-QTAALLESRKN----- 3035
++ E++ L + ++D E F + R Q LLE +
Sbjct: 2057 NWCEKME-ENLSEPVHCVS--LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
Query: 3036 -PESP----------KVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQ---------- 3074
P SP + L + E + L++ EAR E Q +
Sbjct: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
Query: 3075 LERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
LE LD L + T ESQ LE K +++ A ++++ +
Sbjct: 2174 LETRAYFLDGSLLKETGTLESQ-----LEANKRKQKEIQAMKRQLTKI 2216
Score = 327 bits (838), Expect = 1e-88
Identities = 408/2039 (20%), Positives = 788/2039 (38%), Gaps = 194/2039 (9%)
Query: 474 EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEV 533
EE+ W LL+ + Q+ +QE + + + A S G+
Sbjct: 134 EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERT 193
Query: 534 VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALV 593
L ++ + + ++ A V + Q E + ++Q+K + + L L
Sbjct: 194 EVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLA 253
Query: 594 RARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV 653
R+ L F R+ E W+KE + + G+DL G HK LE +
Sbjct: 254 LQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNL 313
Query: 654 HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
+L + L+ P P E E + W+ ++ R +LQ
Sbjct: 314 AVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
Query: 714 QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
++ +D E + W+ E+ +++ D A E LL RH + + + ++ + +E G
Sbjct: 374 RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433
Query: 774 RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
+ L N S + +
Sbjct: 434 Q------DLVNANHEAS---------------------------------------DEVR 448
Query: 834 QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQR--VQPQA 891
+ + L ++ +L L R + E+ + F ++ W+ +Q L+ +
Sbjct: 449 EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL 508
Query: 892 DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLE 951
+ E + K+E+F A + V +A +L +S I+ ++ L R L
Sbjct: 509 GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL- 567
Query: 952 ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL-------Q 1004
REKA ++ LQ+ L++ + + + L L Q
Sbjct: 568 ---REKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ 624
Query: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
+ +K+ V + ++ +Q ++ E G+ S + ++ + L +++ E Q+ +
Sbjct: 625 VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLH 684
Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
E + F ++ L W E V+ Q+ S++ +A Q LR+H L + Q+++
Sbjct: 685 EANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVD 744
Query: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
L + + PDS+++ L + + LK R++ L + L LQ R+ +
Sbjct: 745 ILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTED 804
Query: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQH 1244
A + LG+D+ + LL +HR +++ PR + + G K+V+ H
Sbjct: 805 EEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGH 864
Query: 1245 PAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEK------ 1298
AA V +++S+ L+ R+ +R+ L A++Q Q++ D+ E W+ EK
Sbjct: 865 FAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN 924
Query: 1299 -----------GLMAAHE-----------PSGARRNILQTLKRHEAAESELLATRRHVEA 1336
L+ HE A RN ++ +AA E +A + V A
Sbjct: 925 TNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMA 984
Query: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKW---EALN----------------------- 1370
L + D+ T L + W EA +
Sbjct: 985 LYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQ 1044
Query: 1371 RKMTERGDELQQAGQQEQLLRQLQDAKEQ---------------------LEQLEGALQS 1409
R+ E G+ Q+ Q E R L D E+ LE ++ ++
Sbjct: 1045 RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQ-EKKA 1103
Query: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLEL 1469
TG +L LQK+ + + + T ++ + +A + + E + + L
Sbjct: 1104 ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNS 1163
Query: 1470 LQG---HLAIRGLQLQASVE----LHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQS 1522
G LA QL S H+ + ++ + + P S L Q+
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGS---DLFSVQA 1220
Query: 1523 LHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA-QHIVEQCQELEGHWAELERACE 1581
L R+H+ + ++ G +L + HP A + + Q EL W +L+ +
Sbjct: 1221 LQRRHEGFERDL-VPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279
Query: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
R + L +A F + +L+ W+ +VSS++ D L+ +HQ + ++
Sbjct: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339
Query: 1642 IYWSSMEELDQTAQTL------TGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTL 1695
+ + L+ + L PE+ ++ + V+ R+ L E R + L+ L
Sbjct: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLE-RDDLEKAWE---KRKKILDQCL 1395
Query: 1696 RLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAAC 1755
L F + ++ W+ +++ + + + D A L K + ++
Sbjct: 1396 ELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEA--LMKKRDDLDKAITAQEGKITDL 1453
Query: 1756 RLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVL 1815
AESL+ H A + R Q + W L L D + +RDL E+
Sbjct: 1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELE 1513
Query: 1816 TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQK--LCPG 1873
+ E + + +D ++ + HQ E+ G Q+ ++ + + C G
Sbjct: 1514 EWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDG 1573
Query: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933
+ A++++ + + + W L R + +L A RF T++RD+ W + L +
Sbjct: 1574 NE-EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAM 1632
Query: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993
++ +++ +S L HQ L E+ ARE + L + L + ++ ++ +
Sbjct: 1633 KDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVN 1692
Query: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053
+ V + A E+L+ F ++ E + + + + + G ++ V+ L+
Sbjct: 1693 KRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLL 1752
Query: 2054 RKHEVFLKVLTAQD---KKEAALRERLK---TLRRPRVRDRLPILLQRRMRVKELAESRG 2107
+KH+ L A + + + E+LK + + ++ RL ++ ++KELA++RG
Sbjct: 1753 KKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARG 1812
Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKP----LLKHQAFEAEV 2163
L SL F Q A + E AW + GD D L L+KH+A E +
Sbjct: 1813 LKLEESLEYLQFMQNAEEEE----AWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
Query: 2164 QAHEEVMTSVAKKGEALL---AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
HE + +V +GE +L Q + E+S +++ L + L +A+A +LED
Sbjct: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
F EF + D+ EAWI +KE + G DL L L + +++ + +
Sbjct: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTL--DASLQSFQQERLP 1986
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRW-------ASFHGNLLRYQQQLEGALEIHV 2333
I+DL +L + + K I +R + L RW A LL Q L+ A ++ V
Sbjct: 1987 EITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046
Query: 2334 ----LSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
+ L+N ++++E L + + C L +++L + HE+ + QA + L
Sbjct: 2047 EFAHKASALNNWCEKMEEN--LSEPVHC-VSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
Score = 317 bits (811), Expect = 2e-85
Identities = 433/2131 (20%), Positives = 824/2131 (38%), Gaps = 187/2131 (8%)
Query: 441 ILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV 500
++ +EGR + + A+ +E + + +Q EV W+RL ++K +++ +
Sbjct: 207 LVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANL 266
Query: 501 LSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQ 560
++V A ++E + S G+ L L H LE ++ V L +
Sbjct: 267 QRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAK 326
Query: 561 TAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWL 620
+L S + +Q L + + AL +R L+ T F + +E W+
Sbjct: 327 AEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWM 386
Query: 621 KECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPD 680
E + L D++ L +H+ + E+ + G+DL +
Sbjct: 387 NEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDE 446
Query: 681 PGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQ 740
E+ E + W L R + + L ++ D+ + SW+ + + LE G
Sbjct: 447 VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGN 506
Query: 741 DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
+AE LL++H E AF A+ EE+ + TV+
Sbjct: 507 SLGSAEALLQKHEDFE---EAFTAQ----EEK---------IITVD-------------- 536
Query: 801 PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
K A D +D I +D L ++LR A RR L+E+
Sbjct: 537 ---------------KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581
Query: 861 MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL-----KYENFLTALAVGKGLW 915
+ L +L+ W+ K+ +++ D ++ L K + F LAV K
Sbjct: 582 LLLQKLYEDSDDLKNWINKK----KKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
Query: 916 AEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECG 975
+ + +++ + S + + E++ W +L ++K QL + + F
Sbjct: 638 ENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697
Query: 976 PTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
Q L DV Q+ + G ++ L + + +V L + EE G
Sbjct: 698 DLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIG 757
Query: 1032 YAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLR 1091
+ +S+ ++ + E+L + ++E +A R ++ + Q ++++ W + +
Sbjct: 758 HPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSAT 817
Query: 1092 SKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVL 1151
S + D+ ++++LL H+ +LE I + R+Q++ + M +++V + ++ L
Sbjct: 818 STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSL 877
Query: 1152 GQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSL 1211
Q + L+ +RQ L+ ++ Q++ ++ + + N G D A +L
Sbjct: 878 NQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL 937
Query: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ-HPAAHTVREQ----LQSIQAQWTRLQG 1266
L++H F L++ G +ALR Q Q P EQ L QA+ R
Sbjct: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVT 997
Query: 1267 RSEQRRRQLLASLQLQEWKQDVAE---------LMQWMEEKGLMAAHEPSGARRNILQTL 1317
+ LL+S+ WK + A+ + + ++ M NI Q
Sbjct: 998 MKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ 1057
Query: 1318 KRHEAAESELL--ATRRHVEALQQVGRELLSRRPCG------------------------ 1351
++ E LL A R LQ+ LL+
Sbjct: 1058 EQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQ 1117
Query: 1352 ------QEDIQT---RLQGLRSKWEAL--NRKMTERGDELQQ------------AGQQEQ 1388
Q+D+ T RL+ + + L +T G +++Q A +Q Q
Sbjct: 1118 KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQ 1177
Query: 1389 LL----------RQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
LL R+ D KEQ+E+ AL +++ G DL S Q LQ+RH+ E + L
Sbjct: 1178 LLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGD 1237
Query: 1439 KMAALASMAHGMAAS-PAILEETQKHLRRL----ELLQGHLAIRGLQLQASVELHQFCHL 1493
K+ L A ++ S P E+ Q+ L E LQG R L + + + F
Sbjct: 1238 KVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSK 1297
Query: 1494 SNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAA 1553
+ +W++ S E L G + L +H+E + +++A Q + L
Sbjct: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELID 1357
Query: 1554 SGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPL 1613
SGH + I ++ Q ++ +LE+A E R + L Q + Q + + ++E W+ +
Sbjct: 1358 SGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENS 1417
Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ--E 1671
+ S D ++ L+ K L + + + +L+ A++L E ++ + +
Sbjct: 1418 LRSDDKSSLDSLE-ALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQ 1476
Query: 1672 RLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHA 1731
R+ ++ +AL+ +L L +F R+ E+L+ W++ A E + A
Sbjct: 1477 RVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTA-----CDESYKDA 1531
Query: 1732 LHLCTKFAK---FQHQVEMGSQRVAACRLLAESLLERGHSAG--PMVRQRQQDLQTAWSE 1786
++ K+ K F H+V+ S++V L SL+E G ++++ + L+ W
Sbjct: 1532 TNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDH 1591
Query: 1787 LWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP-NNVARDLCGLEAQLRSHQG 1845
L E T +G L + R + + + + E T L + ARDL L+ HQ
Sbjct: 1592 LLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQL 1651
Query: 1846 LERELVGTERQLQELLETAGRVQKLCPGP-QAHAVQQRQQAVTQAWAVLQRRMEQRRAQL 1904
LERE++ E L++L A + L G + +++ V + + +Q +L
Sbjct: 1652 LEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
Query: 1905 ERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLW 1964
+ A L +F + D SW + ++ ++ L H+ L EL A E
Sbjct: 1710 KEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
Query: 1965 QQATQLGQQALLAAGTPTKEVQ----------EELRALQDQRDQVYQTWARKQERLQAEQ 2014
Q + ++ A +E+Q E+L+ L R + + +Q +
Sbjct: 1770 QNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAE 1829
Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQ--DKKEAA 2072
+E+ ++ E L + T +L E +E HE ++ + AQ D
Sbjct: 1830 EEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKV 1889
Query: 2073 LRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
L+E + + ++ L ++ + + + L F A E WI
Sbjct: 1890 LQEE---SQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIAD 1946
Query: 2133 WAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEV 2191
LK DL D L L K +A +Q+ +E + + + L++ H ++ +
Sbjct: 1947 KETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAI 2006
Query: 2192 SQRLQGLRKHWEDLRQAMALRGQELEDRR--------NFLEFLQRVDLAEAWIQEKEVKM 2243
+R L K WE L +A A+ Q+L +++ F+EF + W ++ E +
Sbjct: 2007 EERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL 2066
Query: 2244 NVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR 2303
+ L QL++ +F + A A + + +L Q+K
Sbjct: 2067 SEPVHCVSLNEIRQLQKDHEDFLASLAR---AQADFKCLLELDQQIKALGVPSSPYTWLT 2123
Query: 2304 RSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL-----DNVTKRIQ-EKEALIQALDC 2357
L W + +Q+L+ V + E+ N + +Q E LD
Sbjct: 2124 VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD- 2182
Query: 2358 GKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESW 2417
G L+ L + E +R+ IQA L + V +++ +A+ W
Sbjct: 2183 GSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQW 2242
Query: 2418 WQLRSRAQKRREALDALHQAQKLQAMLQELL 2448
QL + + L+ QA+ ++ + +E L
Sbjct: 2243 DQLYQLGLRMQHNLEQQIQAKDIKGVSEETL 2273
Score = 290 bits (741), Expect = 2e-77
Identities = 465/2346 (19%), Positives = 900/2346 (38%), Gaps = 241/2346 (10%)
Query: 469 VARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQ 528
V EE+ R Q +L Q +++VA+ L ++ ++L G+
Sbjct: 17 VLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDL---------GK 67
Query: 529 QLAEVVELL---------------QRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSV- 572
+ E V +L Q+H LEA+V +S L ++T E ++G S
Sbjct: 68 WIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSEL-EKTREERFTMGHSAH 126
Query: 573 EVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL 632
E +A L L L+ L + L + L+ ++++ C + W+ + + L
Sbjct: 127 EETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVEL 186
Query: 633 GRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGW 692
G D + +K + + E+ + V++ + + + P P + V W
Sbjct: 187 GEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAW 246
Query: 693 QLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRH 752
+ L+ + R L A + ++ D EA W++E+ L G+D A+E L H
Sbjct: 247 ERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSH 306
Query: 753 VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
LER L + +++ L A+A T++ HP
Sbjct: 307 KGLERNLAVMSDKVKEL-------CAKAEKLTLS---------------------HPS-- 336
Query: 813 DAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGE 872
D I + ++ L +E +RALA R +L+ F S E
Sbjct: 337 ---------------DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDE 381
Query: 873 LQLWLEKQTVLLQRVQPQADTL--EVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYP 930
L W+ ++T + + D EV+ +++ + + + + L
Sbjct: 382 LSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANH 441
Query: 931 GNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ--VQLRDVLLQL 988
S +++ + E L W L L E+ Q ++ F ++ + ++ L+
Sbjct: 442 EASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLEN 501
Query: 989 EAL--QPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQ 1046
E L GS+E + ++ E ++ + K+ + +S+ ++ + L
Sbjct: 502 EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLL 561
Query: 1047 GLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLL 1106
++E+ A R R E+ Q ++S L W + +L E D+ + + +
Sbjct: 562 ARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRV 620
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
++ Q +E+ + + +L+ + Q M S V L + +EL +Q+
Sbjct: 621 QKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKG 680
Query: 1167 QWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLG 1226
L E + +F + + + + ++ G+ + E + L++H ++
Sbjct: 681 TQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ 740
Query: 1227 PRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQ 1286
+ + L + HP + +R + +S+ ++ L+ R+++LL L LQ +
Sbjct: 741 DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICR 800
Query: 1287 DVAELMQWMEE-----------KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
D + W++E K L+A+ + R IL+ + HE ++
Sbjct: 801 DTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEP----------RIQ 850
Query: 1336 ALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQD 1395
+ + G +++ ED+ +R++ L E+L + R ++L+ Q +Q L L +
Sbjct: 851 EITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHE 910
Query: 1396 AKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA 1455
A+ + + E + ++ G D ++ L K+H+ + + M AL + A+
Sbjct: 911 AETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANAC----- 965
Query: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
Q+ +E + G Q + L+ F S E++ M G +
Sbjct: 966 ----QQQQAAPVEGVAGE--------QRVMALYDFQARSPREVT-----MKKGDVLTLLS 1008
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP--------QAQHIVEQCQ 1567
+N +VE HQG V V R LA P + +I ++ +
Sbjct: 1009 SIN--------KDWWKVEAADHQGIVPAVYV--RRLAHDEFPMLPQRRREEPGNITQRQE 1058
Query: 1568 ELEGHWAE-LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAAT 1626
++E + L+RA E R + LQ+ F + + ++ W++EK+ + + G +
Sbjct: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAY-EAGDMLEWIQEKK----AENTGVELDDV 1113
Query: 1627 LRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLREQLRALQELA 1684
L K Q++L + ++++ A L G PE ++ QE L + +LQ LA
Sbjct: 1114 WELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE-LNSRWGSLQRLA 1172
Query: 1685 ATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQ 1744
+ + L + F REA+D + + + QA + G D L + F+
Sbjct: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFERD 1231
Query: 1745 VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTE-- 1802
+ +V AE L E A +++++ +L AW +L T+ R +L + +
Sbjct: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
Query: 1803 -TTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
L RDL ++ + +S +A DL G+E L HQ ++ Q L
Sbjct: 1292 YLFLSKARDLQNWISSIGGMVSS--QELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
Query: 1862 ETAGRVQKLCPGPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
+ + + + G A ++++ QAV L++ E+R+ L++ L F+
Sbjct: 1350 DFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQV 1407
Query: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
SW L+ ++ S S L + L + A+E + +
Sbjct: 1408 ESWMVARENSLRSDDKSSLDSLEAL-MKKRDDLDKAITAQEGKITDLEHFAESLIADEHY 1466
Query: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
+E+ L+ + D+ + ++ +L + F R+ LEE ++ + +
Sbjct: 1467 AKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS----EMLPT 1522
Query: 2041 ALGSSVEEVEQLIR---KHEVF--------------------LKVLTAQDKKEAALRERL 2077
A S ++ + R KH+ F L +A D E A++E+L
Sbjct: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ L ++ LL+R +G L+ + F + E W+ L
Sbjct: 1583 EQL-----KEHWDHLLER-------TNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLL 1630
Query: 2138 KEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG 2197
DL L KHQ E E+ A E+ + + E LL+ ++ ++
Sbjct: 1631 AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDN 1690
Query: 2198 LRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
+ K + ++++ A ++L++ +F Q +D E+WI+EK ++++ D G+DL+
Sbjct: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750
Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
L ++ + G + I+++ D++ +LK++ + I R +Q W
Sbjct: 1751 LLKKHKRLEGELVAH---EPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKEL 1807
Query: 2318 LLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELERE 2377
+LE +LE + + I EK AL DCG L + Q LL KHE LE +
Sbjct: 1808 AKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALEND 1867
Query: 2378 --VHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
VH E V +C + + + + + + E ++ + +K A+
Sbjct: 1868 FAVH---------ETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAI- 1917
Query: 2436 QAQKLQA----MLQELLVSAQRLRA-------QMDTSPAPRSPVEARRMLEEHQECKAEL 2484
A KLQ QE A + A + T+ + +L + A L
Sbjct: 1918 AAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASL 1977
Query: 2485 DSW-TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEH-------QLQ 2536
S+ + + +L++A H S I + A L + L A H QL
Sbjct: 1978 QSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
Query: 2537 LQQALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAG 2595
LQ+A +L + F + W E++L+ L + L H+ L
Sbjct: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
Query: 2596 KISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRL--EELRQL---- 2649
L + + G P + + + + L R L EE RQ+
Sbjct: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFE 2157
Query: 2650 --QAFLQDSQEVAAWLREKNLVALEEGLL-DTAMLPAQLQKQQNFQAELDASMHQQQELQ 2706
Q F Q++ W+ E L+ LL +T L +QL+ + Q E+ A Q ++
Sbjct: 2158 MCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIV 2217
Query: 2707 REGQRL 2712
G L
Sbjct: 2218 DLGDNL 2223
Score = 241 bits (614), Expect = 1e-62
Identities = 215/995 (21%), Positives = 421/995 (42%), Gaps = 22/995 (2%)
Query: 2492 SLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVE 2551
++ S+G ++L ++VL + S + E +L+ + LQ+F +
Sbjct: 8 TVVESSGPKVLETAEEIQERRQEVLTRYQ----SFKERVAERGQKLEDSYHLQVFKRDAD 63
Query: 2552 KMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGG 2611
+ +W+ K + L + DP ++ KH+ LE +++ ++ +S LE T G
Sbjct: 64 DLGKWIMEKVNILTDKSYEDP-TNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMG 122
Query: 2612 HPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVAL 2671
H + + + + L + +L + Q ++Q+ ++ W+ +K +A
Sbjct: 123 HSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIAT 182
Query: 2672 EEGLLDTAMLPAQLQKQ-QNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEEL 2730
L + L K+ ++FQ EL A + E+ + + HP IQ + E+
Sbjct: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
Query: 2731 GALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGEL 2790
A W L+ + ++ L A R +R + E W++ E L + G+ L L
Sbjct: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
Query: 2791 LGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQER 2850
+ + LE + + + + L +A+ A ++E L+ ++ +R R
Sbjct: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
Query: 2851 RTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSH 2910
L+A +F D DE W+ EK A + ++ L ++HQ + E+ S+
Sbjct: 363 YEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY 422
Query: 2911 EALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFL 2970
+ + TG LV A H A+ EV +++ L+ L R +Q + F
Sbjct: 423 DDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
Query: 2971 TELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALL 3030
+ + SW++ + L++ED+G+S + +ALL++ E + A +I + +TA L
Sbjct: 483 RDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKL 542
Query: 3031 ESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKA 3090
+ +S + A + L +A R L+E L L +L ++ L W+ K
Sbjct: 543 IGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK 602
Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
A+ +DY +D++ +K +K F KE+ ++ + ++ ++K + G ++
Sbjct: 603 KLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTGQEMIEGGHYASDNVTT 660
Query: 3151 QRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLS 3210
+ S + + WE L +A K + L A++ F+ A +LQ +++ + ED G L+
Sbjct: 661 RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA 720
Query: 3211 SVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL-HPAAPGGLAKVQE---AWATLQA 3266
V+ ++H LE + A + +V L A ++ HP + A+ + + L+
Sbjct: 721 EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE 780
Query: 3267 KAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQ 3326
R + L ++ AW QE + A+S L +D+ +++LL +H + +
Sbjct: 781 PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE 840
Query: 3327 EIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386
I + Q++ + G ++V+ HF + +V ++ L ++ L A R +
Sbjct: 841 NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ 900
Query: 3387 LQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
Q+ L +AE W+ E ++ +YG LL +H+ F K
Sbjct: 901 FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE----AFLLDLNSFGDSMK 956
Query: 3447 TEMEQELLLQPQELKP--GRAGS----SLTSFQWR 3475
Q Q Q+ P G AG +L FQ R
Sbjct: 957 ALRNQANACQQQQAAPVEGVAGEQRVMALYDFQAR 991
Score = 239 bits (611), Expect = 3e-62
Identities = 363/1900 (19%), Positives = 726/1900 (38%), Gaps = 156/1900 (8%)
Query: 421 PASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRW 480
P +A E + R + I + RFQ+ E L + + +V + E + W
Sbjct: 399 PTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNW 458
Query: 481 QRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRH 540
LL+ + +Q ++ E + + + G L LLQ+H
Sbjct: 459 TALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKH 518
Query: 541 DLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
+ E +A + + + +L E ++A L + +L RR LL
Sbjct: 519 EDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLL 578
Query: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
+++L + + ++ + W+ + +++ + +D+ + +QK + E E+ ++
Sbjct: 579 KESLLLQKLYEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQL 637
Query: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
++ + G+++ + R V W+ L +G +L A LQ+ +A
Sbjct: 638 ENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAE 697
Query: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
+ WL + + G+ A + LR+H LE A +AR
Sbjct: 698 DLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLE-----------------SAVAARQ 740
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
+ + L+ E + +P D I Q+ L
Sbjct: 741 DQVDILTDLAAYFEEIGHP----------------------------DSKDIRARQESLV 772
Query: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL- 899
+E+L+ R+ +L + + L C + + W+++ D + +L
Sbjct: 773 CRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLL 832
Query: 900 -KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958
++ L +A + E++ ++ + + + + + L+Q L A +
Sbjct: 833 NRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQ 892
Query: 959 VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018
L +V+ +L + + +R+ ++ G+ E+ AL L++
Sbjct: 893 NDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGAL---------LKKHEA 943
Query: 1019 FLQSVVVKVEEPGYAES-QPLQGQVETLQGLLKQVQEQVA--QRARRQAETQAR--QSFL 1073
FL ++ + +S + L+ Q Q E VA QR + QAR +
Sbjct: 944 FL------LDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVT 997
Query: 1074 QESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM 1133
+ +L S+ E + +HQ ++ +++ RL + P
Sbjct: 998 MKKGDVLTLLSSINKDWWKVEAA-----------DHQGIVPAVYV--RRLAHDEFPMLPQ 1044
Query: 1134 AALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ 1193
+ P + + + Q + L E+R++ L LQ++ + + A +
Sbjct: 1045 RRREEPGN--ITQRQEQIENQYRSLLDRAEERRRRL-----LQRYNEFLLAYEA--GDML 1095
Query: 1194 AWLH---LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQS--QHPAAH 1248
W+ +N G ++ + L ++ EF + L+T PR + + L+ P
Sbjct: 1096 EWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGA 1155
Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEK-GLMAAHEPS 1307
+R++L S +W LQ ++++R+ L ++ ++ + ++ + + +E+K ++A +P
Sbjct: 1156 QIRQELNS---RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPG 1212
Query: 1308 GARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
++ +RHE E +L+ V L + L P ED+Q + L WE
Sbjct: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272
Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQ 1427
L + +R + L +A + L + +D + + + G + S E +DL + L +RHQ
Sbjct: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332
Query: 1428 QLESESRTLAAKMAALASMA-----HGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQ 1482
+ ++ A AL + G ASP I ++ Q + L+ R L
Sbjct: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILD 1392
Query: 1483 ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQ 1542
+EL F + SW+ + + L+ ++L +K +L + A +G++
Sbjct: 1393 QCLELQMFQGNCDQVESWMVAR-ENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKIT 1451
Query: 1543 RVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSE 1602
+ SL A H + I + Q + W L+ L +Q++ D+ E
Sbjct: 1452 DLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEE 1511
Query: 1603 LEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEV 1662
LE W+ E P Y +D R KHQ E+ + + +L
Sbjct: 1512 LEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSA 1570
Query: 1663 PEQQRVVQERLREQLRALQE-----LAATRD--RELEGTLRLHEFLREAEDLQGWLASQK 1715
+ +E ++EQL L+E L T D ++L R F D + WL S+
Sbjct: 1571 CDGN---EEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWL-SEA 1626
Query: 1716 QAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQ 1775
+ + D A +L K + ++ + LAE LL G + +
Sbjct: 1627 ETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686
Query: 1776 RQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPN-NVARDLC 1834
++ ++ + + EL A L++ + +DL + + ++EK + + + RDL
Sbjct: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQ 1746
Query: 1835 GLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQ 1894
G++ L+ H+ LE ELV E +Q +L+ A +++ Q +Q R + W L+
Sbjct: 1747 GVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQ-EEIQLRLAQFVEHWEKLK 1805
Query: 1895 RRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLR 1954
+ R +LE + +F + +W + ++ L H+ L
Sbjct: 1806 ELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALE 1865
Query: 1955 AELEAREKLWQQATQLGQQAL---LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQ 2011
+ E Q G+ L L + KE+ ++ AL ++ + + A + +L+
Sbjct: 1866 NDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLE 1925
Query: 2012 AEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVF------------ 2059
+ Q F + +E +A +E SLKT+ G+ + + L+ K +
Sbjct: 1926 DDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERL 1985
Query: 2060 -------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHA 2112
K+++AQ + A+ ER L ++ +L + ++L E + A
Sbjct: 1986 PEITDLKDKLISAQHNQSKAIEERYAAL----LKRWEQLLEASAVHRQKLLEKQLPLQKA 2041
Query: 2113 SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEV---QAHEEV 2169
L F A+ +W + + L EPV L + + H+ F A + QA +
Sbjct: 2042 EDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKC 2101
Query: 2170 MTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDL--RQAMALRGQELEDRRNF---LE 2224
+ + ++ +AL S P + L+ KH D+ + L+ +E +NF E
Sbjct: 2102 LLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE 2161
Query: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQD---LEHCLQLRRR 2261
F Q WI E G L ++ LE L+ +R
Sbjct: 2162 FEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKR 2201
Score = 210 bits (534), Expect = 2e-53
Identities = 252/1302 (19%), Positives = 522/1302 (40%), Gaps = 95/1302 (7%)
Query: 2178 EALLAQSHPR----AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
E ++ S P+ A E+ +R Q + ++ ++ +A RGQ+LED + F + D
Sbjct: 7 ETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLG 66
Query: 2234 AWIQEK---------EVKMNVG---DLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRS 2281
WI EK E N+ Q LE +Q + RL + +
Sbjct: 67 KWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLM-------------SELEK 113
Query: 2282 ISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNV 2341
+ + + EE K + +L + W L QL AL+ +E ++
Sbjct: 114 TREERFTMGHSAHEETKAHIE---ELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADI 170
Query: 2342 TKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPE 2401
+ I +KEA+ +++ G+D E + L +K E+ + E+ + +V + + + +
Sbjct: 171 LEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP 230
Query: 2402 AAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTS 2461
++ +Q EV +W +LR A +R++AL Q+ + + E + + + +
Sbjct: 231 DLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSE 290
Query: 2462 PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ 2521
+ V + + H+ + L +D + + ++ LT HP SD Q+ E
Sbjct: 291 DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEK-LTLSHP--SDAPQIQEMKED 347
Query: 2522 ELSSLE---GAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
+SS E +LQ F S +++ W+ K ++ ++ L +A E
Sbjct: 348 LVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEV 407
Query: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGT 2638
LL +H+ + +++ + + + T + L H + + + + AL
Sbjct: 408 LLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
Query: 2639 RRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDT-AMLPAQLQKQQNFQAELDA 2697
R + E+ F +DS++V +W+ + E L ++ A LQK ++F+ A
Sbjct: 468 RHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTA 527
Query: 2698 SMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRL 2757
+ + + +L+ H SE I+ + L A L++ + + L+++ +L
Sbjct: 528 QEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKL 587
Query: 2758 RRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQA 2817
++L+NW+ + +L + + + + Q+ E + Q E + Q
Sbjct: 588 YEDSDDLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQE 646
Query: 2818 FVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK 2877
+ GH + +V + + ++ L E +++ T L + L+F +A++ W+++
Sbjct: 647 MIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV 706
Query: 2878 LPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAA 2937
++DYG+ L+ V++ +H LES +++ + ++ + GH + ++ A
Sbjct: 707 EWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRA 766
Query: 2938 RVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAE 2997
R + L L+ A R+ L Q + + +W+ E S +G
Sbjct: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLI 826
Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLR 3057
A++ LL R ++ + PRI+ + + + + + V ++++++ + L
Sbjct: 827 ASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRA 886
Query: 3058 RAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRK 3117
RA R + L+ +Q Q + + W+ K ++ +YG D E L +K +AF
Sbjct: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
Query: 3118 EVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAH 3177
++ S G + + ALR A + Q A E +A
Sbjct: 947 DLNSFGDS-MKALRNQANACQ-------------------------QQQAAPVEGVAGEQ 980
Query: 3178 EVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE----- 3232
V A + Q R + + KG+ V TL + ++EA + +
Sbjct: 981 RV----MALYDFQARSPREVTMKKGD--------VLTLLSSINKDWWKVEAADHQGIVPA 1028
Query: 3233 --VARL-QTEACRLGQLHPAAPGGLAKVQE----AWATLQAKAQERGQWLAQAAQGHAFL 3285
V RL E L Q PG + + QE + +L +A+ER + L Q
Sbjct: 1029 VYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
++L W QE++ +E ++ +L + +E +++ + +D+ + L
Sbjct: 1089 YEAGDMLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDL 1144
Query: 3346 VDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWE 3405
+ ++ E + QEL R L+ + Q + ++ + + + +
Sbjct: 1145 LFEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKC 1203
Query: 3406 GLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
L D G + V+ L RH+ E+ L +K + +T
Sbjct: 1204 QALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
Score = 150 bits (378), Expect = 3e-35
Identities = 236/1215 (19%), Positives = 467/1215 (38%), Gaps = 133/1215 (10%)
Query: 271 LLQTQYEQLVA----DLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQ 326
LLQ E L+A D+L WI EK+ + + D ++ T E PRL+
Sbjct: 1078 LLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNE--PRLR 1135
Query: 327 Q-RGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQ 385
A+ LLF EGL E +Q Q L R
Sbjct: 1136 DINKVADDLLF-----------------EGLLTPEGAQI-----------RQELNSRWGS 1167
Query: 386 LQRLETLARRFQHKAALRESFLKDAEQVLDQ---------ARAPPASLATVEAAVQRLGM 436
LQRL R+ A E F ++A+ +Q A P + L +V+A +R
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E ++P + L E A+ L + + D+ R++ E+ W+ L + +++ + +
Sbjct: 1228 FERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNE 1287
Query: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556
Q L + + + + S + L + LL+RH A + A
Sbjct: 1288 AQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQA 1347
Query: 557 LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
L +AEL S + ++ K + + + L R+ +L+Q L+ F NC++
Sbjct: 1348 LEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQV 1407
Query: 617 EAWL--KECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARR 674
E+W+ +E R + + L + ++K L+ + + DL L A
Sbjct: 1408 ESWMVARENSLRSDDKS---SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADE 1464
Query: 675 PPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLE 734
+ + R + V W+ L+ +++ +L + Q++ D E W+ S +
Sbjct: 1465 HYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWI----SEML 1520
Query: 735 RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGE 794
+C + A + R++++ + FA E+ GR+ + NS +
Sbjct: 1521 PTACDESYKDATNIQRKYLKHQ----TFAHEV-----DGRSEQVHGVINLGNSLI----- 1566
Query: 795 SLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRR 854
E S G +A K L + L + ++ L +
Sbjct: 1567 ---------ECSACDGNEEAMKEQL-----------------EQLKEHWDHLLERTNDKG 1600
Query: 855 ARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGK 912
+L EA F +S + + WL + LL D L K++ + +
Sbjct: 1601 KKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLARE 1660
Query: 913 GLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQ 972
++++ AE L N QI ++++ +++R+ ++ L +L + + F Q
Sbjct: 1661 DALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQ 1720
Query: 973 ECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKK----TLVLERRVHFLQSVVVKVE 1028
+ + + + L+++ + G L K+ + E + + + K++
Sbjct: 1721 DLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLK 1780
Query: 1029 EPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQA 1088
+ + +Q ++ ++++E R + E+ F+Q +++ W A
Sbjct: 1781 DKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNA 1840
Query: 1089 QLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM---AALDCPDSQEVP 1145
+ +A+ Q LL +H+ L + + + R+Q + AQ + + + ++E+
Sbjct: 1841 LAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEIS 1900
Query: 1146 NTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDV 1205
+ + L ++ L + L++ Q+F + D A A+ + L + G D+
Sbjct: 1901 SKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADL 1960
Query: 1206 REALSLL-QQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
+ L+LL +Q L S R + +KL+ +QH + + E+ ++ +W +L
Sbjct: 1961 GDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQL 2020
Query: 1265 QGRSEQRRRQLL-ASLQLQ-------EWKQDVAELMQW---MEEKGLMAAHEPSGARRNI 1313
S R++LL L LQ E+ + L W MEE H S I
Sbjct: 2021 LEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVS--LNEI 2078
Query: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
Q K HE + L + + L ++ +++ + ++ L W+ L+ +
Sbjct: 2079 RQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDII 2138
Query: 1374 TERGDELQ-QAGQQEQLLRQLQDAKEQLEQ------------LEGALQSSETG---QDLR 1417
ER ELQ + +Q + Q+ ++ L+G+L ETG L
Sbjct: 2139 EEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSL-LKETGTLESQLE 2197
Query: 1418 SSQRLQKRHQQLESE 1432
+++R QK Q ++ +
Sbjct: 2198 ANKRKQKEIQAMKRQ 2212
Score = 103 bits (258), Expect = 2e-21
Identities = 106/452 (23%), Positives = 197/452 (43%), Gaps = 53/452 (11%)
Query: 249 LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
L + +RRL L+E+ LLQ YE DL WI +K+ + D+ D
Sbjct: 567 LREKAATRRRL------LKESLLLQKLYEDS-DDLKNWINKKKKLADDEDYKD------- 612
Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEG---------LGLA 359
Q R+Q++ E L +T L+ + EG L+
Sbjct: 613 ---------IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLS 663
Query: 360 ELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAE-QVLDQAR 418
E++ W L A + L + QLQ F++ A + +L+D E QV +
Sbjct: 664 EVASLWEELLEATKQKGTQLHEANQQLQ--------FENNAEDLQRWLEDVEWQVTSEDY 715
Query: 419 APPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTV 478
LA V+ +++ G+LE+ + ++ + L ++A + + D+ RQE +
Sbjct: 716 GK--GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
Query: 479 RWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
R++ L + L ++K++ D+ + + ++ E ++E + A ST G+ L +LL
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
Query: 539 RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
RH ++ +++H + + ++ ++ + E + ++ ++L Q +SL A R+
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
Query: 599 LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
LE +Q ++L + E E W++E V N G D + AGAL K +H+A
Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGAD-EEAAGALLK---------KHEA 943
Query: 659 VCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
+DL G + A R ++A V+G
Sbjct: 944 FLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975
Score = 42.7 bits (99), Expect = 0.007
Identities = 85/429 (19%), Positives = 171/429 (39%), Gaps = 40/429 (9%)
Query: 264 LQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLL----AAFTIFRTQ 319
L+L+E+ L Q+ Q + WI EK D D+L A + LL A F
Sbjct: 1813 LKLEES-LEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVH 1871
Query: 320 EKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQAL 379
E R+Q A + ++QN+ E+S L + ++A+
Sbjct: 1872 E--TRVQNVCAQGEDILNKVLQEESQNK------------EISSKIEALNEKTPSLAKAI 1917
Query: 380 QQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEA 439
LQL+ + + F KA + E+++ D E L + A L + + L+A
Sbjct: 1918 AAWKLQLED-DYAFQEFNWKADVVEAWIADKETSL-KTNGNGADLGDFLTLLAKQDTLDA 1975
Query: 440 GILP-QEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQ 498
+ Q+ R + ++ D L Q++ + R + RW++LL+ R+++ + Q
Sbjct: 1976 SLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035
Query: 499 AVLSLLQEV--------EAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAH 550
L +++ A ++ E+++E L E+ +L + H+ A ++
Sbjct: 2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARA 2095
Query: 551 GAHVSHLAQQTAELDSSLGT--------SVEVLQAKARTLAQLQQSLVALVRARRALLEQ 602
A L + ++ +LG +VEVL+ + L+ + + ++ A +
Sbjct: 2096 QADFKCLLELDQQI-KALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVK 2154
Query: 603 TLQRA-EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661
+ EF +N W+ E + +L ++ + L+ +K + E+ +
Sbjct: 2155 NFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLT 2214
Query: 662 DLVRRGRDL 670
+V G +L
Sbjct: 2215 KIVDLGDNL 2223
Score = 34.3 bits (77), Expect = 2.3
Identities = 81/354 (22%), Positives = 137/354 (38%), Gaps = 48/354 (13%)
Query: 286 WIAEKQMQLEAR-------DFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRL 338
WIA+K+ L+ DF L L A+ F+ QE+ P + + L+
Sbjct: 1943 WIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQ-QERLPEITD--LKDKLISAQ 1999
Query: 339 QTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH 398
+A R A L + W L A A Q L ++ L LQ+ E L F H
Sbjct: 2000 HNQSKAIEER---------YAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAH 2050
Query: 399 KAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADIL 458
KA+ ++ + E+ L + SL + + A + + F+ L E+ +
Sbjct: 2051 KASALNNWCEKMEENLSEP-VHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQI 2109
Query: 459 R----QEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQA----VLSLLQEVEA- 509
+ ++W V E + W+ L ++ + +++ +A + QE E
Sbjct: 2110 KALGVPSSPYTWLTV----EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQN 2165
Query: 510 ASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDS--S 567
AS L+ + E G LL+ LE+Q+ A+ + +L
Sbjct: 2166 ASTFLQWILETRAYFLDG-------SLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Query: 568 LGTSVE---VLQAKART--LAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
LG ++E +L K T LAQ L L + LEQ +Q A+ ++ EE
Sbjct: 2219 LGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQ-AKDIKGVSEE 2271
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 358 bits (920), Expect = 4e-98
Identities = 660/2892 (22%), Positives = 1152/2892 (39%), Gaps = 414/2892 (14%)
Query: 10 IRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPP 69
I L+ ++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP
Sbjct: 11 ISSLKDERDRVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR 68
Query: 70 PSRGRLRVHFLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHI 128
+GR+R H L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I
Sbjct: 69 -EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI 127
Query: 129 SLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDL 188
+ + +A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L
Sbjct: 128 QVSGQSEDMTA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLL 182
Query: 189 LDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSR 248
+D + L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R
Sbjct: 183 IDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR 242
Query: 249 LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
+ Q R E +L +Y +LV LL+W+ E R FP S +
Sbjct: 243 VPDVQDGVR--------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEI 294
Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAG 367
L + F F+ E P + + ++ + L+ A+QA Q + P G ++ + W
Sbjct: 295 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGK 350
Query: 368 LEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATV 427
L A R + L+ +L+ L+ + + Q +A L E L A+ +L L
Sbjct: 351 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAA 406
Query: 428 EAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ- 481
QR G +E + + + L L+ ++ + RR + V +R +
Sbjct: 407 GKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY 466
Query: 482 --RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539
RL + QVA + + S+ + E L LQ+ Q + E
Sbjct: 467 NLRLKAGVAAPATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD 525
Query: 540 HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRA 595
+EAQ+ +H + + A+++ + ++ A L +L L+ +
Sbjct: 526 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS 585
Query: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655
+A L F+ +E WL E + + + + + AL E+
Sbjct: 586 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715
+ +L G L P +P A+Q W + A L+ Q+
Sbjct: 646 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 705
Query: 716 FADAAEAASWLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGR 774
F+D EA L++ + +L R SC D++A T RLE +L+ E +L E
Sbjct: 706 FSDVREAEGQLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKG 757
Query: 775 AASARASLFTVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD-- 824
S A L P P +R P + + GD ++ PA+P
Sbjct: 758 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817
Query: 825 ------------PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSS 869
P P + Q+ +++ +AL L + +L + S
Sbjct: 818 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877
Query: 870 CGELQLWLEKQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQ 927
++QL + ++P Q L ++L Y+ FL G E AE +
Sbjct: 878 RRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---R 934
Query: 928 RYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQ 987
Y S Q+ + L Q G E + ++ + +L+D+ LQ
Sbjct: 935 EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQ 973
Query: 988 LEALQPGSSEDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE----------------- 1028
LEA + T H L+L K E +R+ Q +VE
Sbjct: 974 LEACE----TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029
Query: 1029 ---EPGYAESQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARR 1062
EP A + L+ ++E G L+QV+ E+V +
Sbjct: 1030 ALPEPSPA-APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1088
Query: 1063 Q-AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDL 1112
Q E QA + L E + + ++AQ +++ + D +RL + H +
Sbjct: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148
Query: 1113 LEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEG 1172
E+ W+ER+ QL + Q + A +E L LG+Q + + + WLQ+
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDA 1204
Query: 1173 LELQKFGR-----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLL 1222
Q+ + + QA L ++ GE V E +Q+ +++ L
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1264
Query: 1223 STLGPRAEALRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
T + E + + +K VQS + +V ++ ++ ++ L + Q + + +L+
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321
Query: 1282 QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVG 1341
E ++ +AE Q EE+ +A E A Q + H A+++ A R E Q++
Sbjct: 1322 MEEEERLAE-QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ 1376
Query: 1342 RELLSRRPCG------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG----------- 1384
E++ R + IQ LQ LR EA + + + +++
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 1385 -QQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAAL 1443
Q E RQ A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAE 1492
Query: 1444 ASMAHGMAASPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWV 1501
+A + A E Q+ L+ LE LQ A R L+ QA VE + ++
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRS 1551
Query: 1502 AEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQH 1561
AE S+ E L R +E V V + + +R A +A+
Sbjct: 1552 AEAELQSKRASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAER 1600
Query: 1562 IVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGR 1621
E+ + W +A EA LQ QQ L +E E EE R
Sbjct: 1601 AREEAERELERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 1622 DEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQ 1681
++A R + + + ++ ++ + L + + EQ ++ L E+L LQ
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 1682 ELAAT---RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKF 1738
AA + +ELE E + +++ LAS+ +A + S E + L +
Sbjct: 1719 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEA 1771
Query: 1739 AKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHAL 1798
+F+ E+ + L E+ +R + RQR + A L E A G A
Sbjct: 1772 GRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEAT 1824
Query: 1799 R-DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQL 1857
R TE + + E E+ L + A LE Q H+ E +L
Sbjct: 1825 RLKTEAEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERL 1873
Query: 1858 QELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAV 1917
+L + + + G ++QR+Q + A+ + + E L R R+
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933
Query: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA 1977
D R ++ ++E + Q + L AE E R + ++ Q A
Sbjct: 1934 ED----TLRSKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSL 2037
A K EE+ L+ + ++ R +ER + E QL L + + + A E
Sbjct: 1978 AARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKA 2031
Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRM 2097
A+ +E++Q +++ + L L + + A R + RV+
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE--------- 2079
Query: 2098 RVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLL 2154
+E A+SR A L S + A QA QA A++L++ R + L
Sbjct: 2080 --REAAQSRRQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
Query: 2155 KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQ 2214
+ QA +AE++ H+ K E L Q +V Q L LR L+ +
Sbjct: 2137 QKQAADAEMEKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLE 2174
Query: 2215 ELEDRRNFL-EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAG 2271
E + ++N L E LQR+ + EA Q +V+ + + +E +L+ R+
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--------- 2225
Query: 2272 DTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEI 2331
+ A I D + + + E++K Q E A +
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAEKMK------------------------QVAEEAARL 2261
Query: 2332 HVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLERE 2391
V ++E + + +E A +AL +++L++ + +E ++A+ E L+++
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 2392 VGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSA 2451
+ + E A L+ ++++A+ QL Q + L+A Q Q E+ A
Sbjct: 2314 K----ELAQEQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEA 2360
Query: 2452 QRLR---AQMDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTA 2504
+RL+ A+M + A R+ +A+R ++ +E +L + + ++L ++ Q +
Sbjct: 2361 ERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 2505 GHPFSSDIRQVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS-- 2548
H + +R+ +A LE+E L + QE LQ QAL+ Q FLS
Sbjct: 2420 DHD-AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEK 2477
Query: 2549 -SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARG 2606
S+ + ER++ +E + + D +A + L + + + +E + + ++++E R
Sbjct: 2478 DSLLQRERFI-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536
Query: 2607 LHQG--GHPEAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AA 2661
H+ G Q L + + ++E L + R R +L+ L Q +A L S+EV A+
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Query: 2662 WLREKNLVALEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQ 2714
+ + LD A+ L+++ + Q +A + +ELQR Q
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ---- 2652
Query: 2715 GGHPASEAIQER 2726
GH + + R
Sbjct: 2653 -GHTTVDELARR 2663
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 403 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 462
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 463 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 522
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 523 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 581
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 582 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 637
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 638 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 698 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 758 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 818 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 878 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 932
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 933 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 992
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 993 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1033
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1090
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1150
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1206
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1556
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1617 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1725 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1778 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1830
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1890
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2068
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2127
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2182
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2237
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2293
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2294 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2342
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2343 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2446
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2447 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2496
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 362 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 418
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 419 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 478
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 479 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 522
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 523 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 577
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 578 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 630
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 631 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 690
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 691 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 740
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 741 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 772
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 773 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 818
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 819 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 875
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 876 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 930
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 931 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 990
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1107
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1162
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1282
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1340
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1401 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1512
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1563
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1564 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1610
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1611 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1848
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2081
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2188
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2189 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2210
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2211 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2262
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2263 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2300
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2301 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2350
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2351 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2390
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2391 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2429
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2430 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2470
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2580
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 501 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 560
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 561 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 617
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 618 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 677
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 678 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 737
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 738 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 793
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 794 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 853
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 854 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 913
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 914 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 973
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 974 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1034 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1092
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1093 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1152
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1213 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1255
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1256 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1305
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1306 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1408
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1409 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1461 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1518 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1575 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1628
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1687
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1721
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1774
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1775 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1828
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1829 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1880
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1940
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2000
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2001 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2054
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2169
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2170 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2191
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2192 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2244
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2305 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2423 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2479
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2538 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2588 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2627
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2628 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2683
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2684 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2720
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 322 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 376
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 377 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 436
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 437 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 493
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 494 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 546
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 547 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 604
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 605 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 664
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 665 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 724
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 725 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 779
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 780 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 839
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 840 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 900 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 959
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 960 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1015
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1016 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1132
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1133 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1184
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1240
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1360
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1412
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1413 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1469 QAQEEAERL 1477
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 256 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 316 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 371
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 372 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 428
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 429 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 488
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 489 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 548
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 549 KIERARSDEGQL 560
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 42 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 98
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 99 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 158
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 159 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 213
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 214 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 273
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 274 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 325
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 326 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 381
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 382 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 437
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 438 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 498 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 556
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 557 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 616
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 617 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 677 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 736
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 737 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 908
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 909 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 965
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 966 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1000
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1001 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1059
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1060 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1296 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1353 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1407
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1468 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1523
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1583 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1631
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1632 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1750 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1799
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1856 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1904
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1960
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1961 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 2009 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2062
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2108
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2109 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2168 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2205
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2256
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2257 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2292
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2293 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2340
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2341 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2391
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2449
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2508
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2509 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2682
Query: 2724 QER 2726
R
Sbjct: 2683 ARR 2685
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 425 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 485 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 545 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 603
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 604 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 659
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 660 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 719
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 720 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 780 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 839
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 840 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 899
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 900 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 954
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1015 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1055
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1112
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1228
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1578
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1639 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1747 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1800 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1852
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2090
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2204
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2259
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2315
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2316 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2364
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2365 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2468
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2469 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 440
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 501 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 544
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 545 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 599
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 600 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 652
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 653 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 712
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 713 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 762
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 763 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 794
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 795 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 840
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 841 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 897
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 898 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 952
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 953 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1012
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1129
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1184
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1362
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1423 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1534
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1585
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1586 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1632
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1633 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2103
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2210
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2211 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2232
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2233 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2284
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2285 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2322
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2323 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2372
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2373 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2413 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2451
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2452 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2492
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2602
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 523 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 583 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 640 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 699
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 700 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 759
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 760 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 815
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 816 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 875
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 876 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 935
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 936 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 996 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1056 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1235 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1277
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1278 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1328 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1430
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1431 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1483 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1540 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1597 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1650
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1709
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1743
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1796
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1797 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1851 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1902
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2023 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2076
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2191
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2192 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2213
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2214 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2266
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2327 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2445 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2501
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2560 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2610 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2649
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2650 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2705
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 344 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 398
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 399 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 515
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 516 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 568
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 569 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 626
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 627 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 686
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 687 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 746
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 747 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 801
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 982 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1037
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1038 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1154
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1155 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1206
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1262
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1434
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1435 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1491 QAQEEAERL 1499
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 338 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 393
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 394 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 450
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 451 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 510
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 511 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 570
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 571 KIERARSDEGQL 582
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 46 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 102
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 103 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 162
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 163 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 217
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 218 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 277
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 278 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 329
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 330 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 385
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 386 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 441
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 442 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 501
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 502 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 560
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 561 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 620
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 621 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 680
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 681 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 740
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 741 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 792
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 793 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 852
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 853 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 912
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 913 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 969
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 970 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1004
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1005 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1063
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1064 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1123
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1299
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1300 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1357 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1411
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1472 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1527
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1586
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1587 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1635
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1636 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1754 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1803
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1859
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1860 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1908
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1964
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1965 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 2013 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2066
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2112
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2113 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2171
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2172 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2209
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2260
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2261 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2296
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2297 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2344
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2345 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2395
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2396 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2453
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2454 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2512
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2513 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2572 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2686
Query: 2724 QER 2726
R
Sbjct: 2687 ARR 2689
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 429 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 488
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 489 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 548
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 549 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 607
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 608 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 663
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 664 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 723
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 724 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 783
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 784 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 843
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 844 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 903
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 904 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 958
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1019 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1059
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1060 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1116
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1176
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1232
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1582
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1643 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1751 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1804 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1856
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1916
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2094
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2153
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2208
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2263
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2319
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2320 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2368
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2369 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2472
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2473 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2522
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 388 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 444
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 504
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 505 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 548
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 549 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 603
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 604 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 656
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 657 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 716
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 717 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 766
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 767 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 798
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 799 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 844
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 845 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 901
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 902 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 956
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 957 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1016
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1076
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1133
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1188
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1308
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1366
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1427 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1538
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1589
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1590 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1636
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1637 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2107
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2214
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2215 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2236
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2237 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2288
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2289 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2326
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2327 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2376
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2377 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2417 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2455
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2456 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2496
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2606
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 527 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 586
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 587 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 643
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 644 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 703
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 704 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 763
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 764 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 819
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 820 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 879
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 880 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 939
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 940 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 999
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 1000 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1059
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1060 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1118
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1119 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1178
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1239 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1281
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1282 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1331
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1332 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1434
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1435 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1487 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1544 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1601 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1654
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1713
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1747
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1800
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1801 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1854
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1855 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1906
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2027 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2080
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2195
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2196 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2217
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2218 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2270
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2331 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2449 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2505
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2564 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2614 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2653
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2654 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2709
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2710 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2746
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 348 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 402
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 403 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 462
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 463 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 519
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 520 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 572
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 573 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 630
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 631 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 690
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 691 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 750
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 751 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 805
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 806 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 865
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 866 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 926 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 985
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 986 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1041
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1042 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1101
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1102 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1158
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1159 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1210
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1211 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1266
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1386
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1438
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1439 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1495 QAQEEAERL 1503
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 282 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 342 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 397
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 398 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 454
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 455 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 514
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 515 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 574
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 575 KIERARSDEGQL 586
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 42 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 98
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 99 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 158
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 159 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 213
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 214 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 273
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 274 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 325
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 326 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 381
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 382 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 437
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 438 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 498 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 556
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 557 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 616
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 617 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 677 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 736
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 737 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 908
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 909 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 965
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 966 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1000
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1001 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1059
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1060 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1296 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1353 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1407
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1468 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1523
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1583 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1631
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1632 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1750 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1799
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1856 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1904
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1960
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1961 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 2009 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2062
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2108
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2109 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2168 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2205
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2256
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2257 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2292
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2293 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2340
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2341 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2391
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2449
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2508
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2509 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2682
Query: 2724 QER 2726
R
Sbjct: 2683 ARR 2685
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 425 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 485 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 545 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 603
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 604 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 659
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 660 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 719
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 720 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 780 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 839
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 840 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 899
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 900 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 954
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1015 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1055
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1112
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1228
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1578
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1639 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1747 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1800 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1852
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2090
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2204
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2259
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2315
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2316 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2364
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2365 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2468
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2469 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 440
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 501 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 544
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 545 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 599
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 600 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 652
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 653 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 712
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 713 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 762
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 763 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 794
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 795 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 840
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 841 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 897
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 898 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 952
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 953 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1012
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1129
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1184
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1362
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1423 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1534
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1585
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1586 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1632
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1633 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2103
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2210
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2211 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2232
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2233 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2284
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2285 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2322
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2323 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2372
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2373 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2413 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2451
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2452 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2492
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2602
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 523 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 583 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 639
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 640 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 699
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 700 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 759
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 760 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 815
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 816 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 875
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 876 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 935
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 936 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 996 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1056 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1235 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1277
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1278 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1328 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1430
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1431 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1483 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1540 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1597 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1650
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1709
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1743
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1796
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1797 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1851 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1902
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2023 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2076
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2191
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2192 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2213
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2214 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2266
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2327 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2445 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2501
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2560 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2610 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2649
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2650 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2705
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 344 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 398
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 399 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 515
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 516 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 568
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 569 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 626
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 627 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 686
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 687 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 746
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 747 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 801
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 982 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1037
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1038 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1154
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1155 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1206
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1262
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1434
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1435 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1491 QAQEEAERL 1499
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 338 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 393
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 394 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 450
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 451 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 510
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 511 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 570
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 571 KIERARSDEGQL 582
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 10 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 66
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 67 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 126
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 127 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 181
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 182 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 241
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 242 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 293
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 294 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 349
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 350 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 405
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 406 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 465
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 466 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 524
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 525 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 584
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 585 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 644
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 645 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 704
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 705 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 756
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 757 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 816
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 817 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 876
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 877 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 933
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 934 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 968
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 969 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1027
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1028 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1087
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1264 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1321 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1375
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1436 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1491
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1550
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1551 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1599
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1600 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1718 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1767
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1823
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1824 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1872
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1928
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1929 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 1977 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2030
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2076
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2077 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2135
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2136 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2173
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2224
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2225 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2260
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2261 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2308
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2309 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2359
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2360 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2417
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2418 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2476
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2477 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2536 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2650
Query: 2724 QER 2726
R
Sbjct: 2651 ARR 2653
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 393 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 452
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 453 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 512
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 513 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 571
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 572 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 627
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 628 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 687
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 688 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 747
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 748 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 807
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 808 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 867
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 868 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 922
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 982
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 983 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1023
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1024 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1080
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1140
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1196
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1546
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1607 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1715 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1768 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1820
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1880
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2058
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2117
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2172
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2227
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2283
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2284 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2332
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2333 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2436
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2437 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2486
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 352 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 408
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 409 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 468
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 469 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 512
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 513 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 567
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 568 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 620
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 621 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 680
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 681 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 730
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 731 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 762
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 763 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 808
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 809 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 865
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 866 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 920
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 921 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 980
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1040
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1097
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1152
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1272
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1330
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1391 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1502
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1553
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1554 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1600
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1601 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2071
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2178
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2179 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2200
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2201 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2252
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2253 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2290
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2291 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2340
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2341 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2381 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2419
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2420 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2460
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2570
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 491 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 550
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 551 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 607
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 608 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 667
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 668 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 727
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 728 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 783
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 784 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 843
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 844 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 903
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 904 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 963
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 964 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1023
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1024 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1082
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1083 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1142
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1203 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1245
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1246 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1295
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1296 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1398
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1399 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1451 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1508 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1565 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1618
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1677
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1711
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1764
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1765 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1818
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1819 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1870
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 1991 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2044
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2159
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2160 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2181
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2182 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2234
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2295 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2413 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2469
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2528 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2578 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2617
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2618 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2673
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2674 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2710
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 312 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 366
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 367 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 426
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 427 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 483
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 484 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 536
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 537 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 594
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 595 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 654
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 655 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 714
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 715 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 769
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 770 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 829
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 830 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 890 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 949
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 950 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1005
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1006 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1065
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1066 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1122
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1123 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1174
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1175 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1230
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1350
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1402
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1403 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1459 QAQEEAERL 1467
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 246 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 306 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 361
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 362 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 418
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 419 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 478
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 479 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 538
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 539 KIERARSDEGQL 550
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 179 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 235
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 236 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 295
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 296 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 350
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 351 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 410
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 411 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 462
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 463 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 518
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 519 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 574
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 575 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 634
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 635 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 693
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 694 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 753
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 754 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 813
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 814 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 873
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 874 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1045
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1102
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 1103 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1137
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1138 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1196
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1197 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1256
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1433 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1490 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1544
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1605 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1660
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1719
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1720 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1768
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1769 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1887 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1936
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1992
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1993 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 2041
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 2097
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 2098 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 2146 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2199
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2245
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2246 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2305 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2342
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2393
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2394 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2429
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2430 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2477
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2478 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2528
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2529 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2586
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2645
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2646 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2819
Query: 2724 QER 2726
R
Sbjct: 2820 ARR 2822
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 562 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 621
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 622 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 681
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 682 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 740
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 741 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 796
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 797 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 856
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 857 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 917 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 976
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 977 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 1036
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 1037 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 1091
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1152 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1192
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1249
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1309
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1365
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1715
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1776 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1884 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1937 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1989
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 2049
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2227
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2286
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2341
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2396
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2452
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2453 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2501
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2502 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2605
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2606 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2655
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 577
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 638 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 681
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 682 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 736
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 737 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 789
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 790 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 849
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 850 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 899
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 900 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 931
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 932 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 977
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 978 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 1034
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 1035 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 1089
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 1090 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1149
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1266
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1321
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1441
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1499
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1560 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1671
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1722
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1723 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1769
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1770 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2240
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2347
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2348 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2369
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2370 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2421
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2422 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2459
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2460 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2509
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2510 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2550 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2588
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2589 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2629
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2739
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 660 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 719
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 720 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 776
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 777 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 836
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 837 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 896
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 897 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 952
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 953 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 1012
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 1013 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 1072
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 1073 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1132
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 1133 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1193 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1251
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1252 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1372 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1414
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1415 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1464
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1465 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1567
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1568 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1620 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1677 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1734 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1787
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1846
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1880
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1933
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1934 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1987
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1988 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 2039
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2160 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2213
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2328
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2329 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2350
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2351 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2403
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2464 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2582 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2638
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2697 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2747 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2786
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2787 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2842
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2843 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2879
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 481 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 535
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 536 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 595
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 596 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 652
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 653 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 705
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 706 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 763
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 764 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 823
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 824 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 883
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 884 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 938
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 939 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 998
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1118
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 1119 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1174
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1175 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1291
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1292 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1343
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1399
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1519
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1571
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1572 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1628 QAQEEAERL 1636
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 475 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 530
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 531 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 587
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 588 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 647
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 648 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 707
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 708 KIERARSDEGQL 719
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 28 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 84
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 85 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 144
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 145 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 199
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 200 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 259
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 260 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 311
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 312 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 367
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 368 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 423
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 424 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 483
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 484 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 542
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 543 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 602
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 603 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 662
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 663 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 722
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 723 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 775 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 835 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 894
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 895 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 951
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 952 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 986
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 987 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1045
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1046 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1105
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1106 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1221
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1281
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1282 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1339 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1393
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1454 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1509
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1568
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1569 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1617
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1618 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1736 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1785
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1841
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1842 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1890
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1946
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1947 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 1995 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2048
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2094
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2095 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2153
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2154 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2191
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2242
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2243 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2278
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2279 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2326
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2327 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2377
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2378 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2435
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2436 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2494
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2495 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2554 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2668
Query: 2724 QER 2726
R
Sbjct: 2669 ARR 2671
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 411 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 470
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 471 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 530
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 531 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 589
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 590 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 645
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 646 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 705
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 706 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 765
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 766 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 825
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 826 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 885
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 886 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 940
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 941 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1001 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1041
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1042 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1098
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1158
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1214
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1564
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1625 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1733 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1786 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1838
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1898
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2076
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2135
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2190
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2245
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2301
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2302 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2350
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2351 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2454
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2455 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2504
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 370 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 426
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 427 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 486
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 487 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 530
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 531 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 585
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 586 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 638
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 639 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 698
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 699 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 748
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 749 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 780
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 781 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 826
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 827 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 883
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 884 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 938
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 939 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 998
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1058
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1115
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1170
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1231 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1290
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1348
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1409 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1520
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1571
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1572 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1618
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1619 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1856
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2089
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2196
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2197 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2218
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2219 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2270
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2271 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2308
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2309 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2358
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2359 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2398
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2399 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2437
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2438 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2478
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2588
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 509 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 568
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 569 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 625
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 626 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 685
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 686 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 745
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 746 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 801
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 802 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 861
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 862 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 921
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 922 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 981
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 982 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1041
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1042 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1100
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1101 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1221 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1263
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1264 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1313
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1314 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1416
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1417 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1469 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1525
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1526 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1583 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1636
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1695
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1755
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1756 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1729
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1782
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1783 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1837 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1888
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2008
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2009 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2062
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2177
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2178 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2199
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2200 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2252
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2313 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2431 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2487
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2546 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2596 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2635
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2636 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2691
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2692 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2728
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 330 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 384
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 385 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 444
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 445 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 501
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 502 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 554
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 555 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 612
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 613 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 672
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 673 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 732
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 733 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 787
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 788 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 847
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 848 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 908 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 967
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 968 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1023
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1024 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1083
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1084 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1140
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1141 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1192
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1193 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1248
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1309 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1368
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1369 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1420
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1421 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1477 QAQEEAERL 1485
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 264 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 324 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 379
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 380 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 436
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 437 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 496
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 497 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 556
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 557 KIERARSDEGQL 568
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 357 bits (917), Expect = 9e-98
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 69 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 125
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 126 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 185
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 186 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 240
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 241 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 300
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 301 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 352
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 353 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 408
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 464
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 465 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 524
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 525 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 583
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 584 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 643
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 644 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 703
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 704 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 763
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 764 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 816 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 876 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 935
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 936 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 992
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 993 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1027
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1028 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1086
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1087 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1146
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
Query: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
Query: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1323 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1380 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1434
Query: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1495 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1550
Query: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1609
Query: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1610 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1658
Query: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1659 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
Query: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1777 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1826
Query: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1882
Query: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1883 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1931
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1987
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1988 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 2036 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2089
Query: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2135
Query: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2136 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2194
Query: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2195 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2232
Query: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2283
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
D + + + E++K Q E A + V ++E
Sbjct: 2284 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2319
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2320 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2367
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2368 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2418
Query: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2419 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2476
Query: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2535
Query: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2536 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
Query: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654
Query: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2709
Query: 2724 QER 2726
R
Sbjct: 2710 ARR 2712
Score = 177 bits (450), Expect = 1e-43
Identities = 469/2214 (21%), Positives = 828/2214 (37%), Gaps = 399/2214 (18%)
Query: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 452 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 511
Query: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 512 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 571
Query: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 572 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 630
Query: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 631 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 686
Query: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 687 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 746
Query: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
+A G ALR D T+ DLL+ +E+
Sbjct: 747 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806
Query: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
P + A + G + ++ H+G E +LVG +
Sbjct: 807 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 866
Query: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 867 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 926
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 927 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 981
Query: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 982 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041
Query: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 1042 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1082
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1139
Query: 2138 KEPV---------------------------PPGD-LRDKLKPLL--------KHQAFEA 2161
KE P D LRD+L+ +H +
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1199
Query: 2162 EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN 2221
EV+ E + + ++ +A+LAQ+ R E+ Q + LR + R++ G L+D R
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY----RESADPLGAWLQDARR 1255
Query: 2222 FLEFLQRVDLAEAWI------QEKEVKMNVGDLGQDLEHC---------------LQL-- 2258
E +Q + LA++ QE+ + + G+ +E C LQL
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315
Query: 2259 -RRRLREFRGNSAGDTV---GDACIRSISDLSLQLKN-----------------RDPEEV 2297
+ +L + V ++ I+ DL R EE
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375
Query: 2298 KIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLS-RELDNVTKRIQEK-----EAL 2351
++ Q+R++ R A L + +Q E + + RE + +R+QE+ EA
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 2352 IQALDCGKDLESVQRLLRKHEE-------------------LEREVHPIQAQVESLEREV 2392
+ A + ++ + LR+ E +E E+ ++ Q+E+ ER+
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495
Query: 2393 G-------RLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML- 2444
G L R+ EA R Q+E Q++ +Q++R+A L K +A
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 2445 ---QELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQL 2501
Q L + + LR Q + + E R ++ + L++ RS +L
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERA----RQVQVALET------AQRSAEAEL 1605
Query: 2502 LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-MERWLCSK 2560
+ F+ Q+ L++E ++ +E + + QQ E + E+ +ERW
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665
Query: 2561 EDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
++L + +A + L QA E R + G E Q+
Sbjct: 1666 NEALRLRLQAEEVAQQKSL------------AQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 2621 RCQAMLLRKEALFRQAGTRRHRL---EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLD 2677
R A ++ GT + RL +EL +L+A + ++ L E+ E
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGEL 2737
T QK+Q +AEL + + L R + SE ++RLE + EL
Sbjct: 1774 T-------QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 2738 QDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQREL 2797
+ + A+L+ E + +R + E + + E E + + L +GE + E
Sbjct: 1827 AEEA----ARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLAAIGEATRLKTEA 1879
Query: 2798 EAAVDKKARQAEAL--LGQAQAFVREG--HCLAQ---DVEEQARRL-------LQRFKSL 2843
E A+ +K + E L L + +AF R AQ D+EE+ +L L+R K L
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1939
Query: 2844 REPLQERRTALEARSLLLKF------------------FRDADEEMAWVQEKLPLAAAQD 2885
E +R +E L LK R E+ +E+ L AA+
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHE--ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
+ R +E + ++ +++ E A R + ++A A + R +Q
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 2944 KAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL 3003
L EAA++RL ++ A + E L + VLD + AEA +
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAEAARRAA 2117
Query: 3004 RRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV-----REAHAELLRR 3058
E + E + + R + A L+ E + AQ QA +EA E RR
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAE-EQAQARAQAQAAAEKLRKEAEQEAARR 2176
Query: 3059 AEARGHGLQE------QLQLH-----QLERETLLLDAWLTTKAATAESQDYGQDLEGVKV 3107
A+A L++ +++ H Q R+ ++ LTT E D+ ++L
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----- 2231
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
L+E+ + E + + +L + + ++RIEA L K
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQ-----MEELSKLKARIEAENRALILRDK 2286
Query: 3168 ARTENLAA--AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERE 3225
T+ A ++ + AA L QE L + + L+ R L + + L+ +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE--EDLAQQRALAE--KMLKEK 2342
Query: 3226 LEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFL 3285
++A++ E RL+ EA L Q A QE LQ ++ Q LA+ QG
Sbjct: 2343 MQAVQ-EATRLKAEAELLQQQKELA-------QEQARRLQEDKEQMAQQLAEETQGF--- 2391
Query: 3286 GRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQL 3345
Q L ++RQ S+E AE+L + E+ + AQ R++ +++
Sbjct: 2392 ---QRTLEAERQRQLEMSAE--------AERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 3346 VDNSH---FMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
+ H + E +Q LE + Q+ + + AE L++ +++L+Q EA L
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---LEREKEKLQQ-EAKL- 2495
Query: 3403 CWEGLLLKPDYGHSVSDVELL-----LHRHQDLEKLLAAQEEKFAQMQKTEMEQ 3451
L LK + +V +LL L + EK Q E+F + +K ++EQ
Sbjct: 2496 ----LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2545
Score = 167 bits (422), Expect = 2e-40
Identities = 535/2512 (21%), Positives = 942/2512 (37%), Gaps = 444/2512 (17%)
Query: 1038 LQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV 1097
L+ + E L+ L + V + + + + + LQ +LL + Q R+ EV
Sbjct: 411 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQ---RAGEVER 467
Query: 1098 DVASAQRLLR---------------EHQDLLEEIHLWQERLQQLDAQS--QPMAALDCPD 1140
D+ A ++R + + + ++ ERL + + + A + P
Sbjct: 468 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 527
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHLD 1199
+Q TL Q Q L + ++LQ+ L +++ VDG W
Sbjct: 528 TQVAQVTL----QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG--------AEW---- 571
Query: 1200 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
G D+ + L HR + + + E R+ +L + A R+ L +
Sbjct: 572 --GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA---YRDCLGRLDL 626
Query: 1260 QWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG---ARRNILQT 1316
Q+ +L S+ R R L + L + + + W+ EK E G + RN T
Sbjct: 627 QYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEK----EEEEVGFDWSDRNTNMT 679
Query: 1317 LKR--HEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT 1374
K+ + A EL + ++ LQ G LL + +++ L+++W + +
Sbjct: 680 AKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC 739
Query: 1375 ERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESR 1434
L++ Q +++A+ QL++L+ AL+ + + RL+
Sbjct: 740 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLED---------- 789
Query: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
+L++ Q +L +GHL+ + +A V+L
Sbjct: 790 ---------------------LLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQL------- 821
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL-----SSGR 1549
P + G L QVEV H+G +++ S +
Sbjct: 822 --------------KPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 867
Query: 1550 SLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVT--FQQYFLDVSELEGWV 1607
L++SG A + C + E + A R + QA+ + Q +D+ L W
Sbjct: 868 VLSSSGSEAA--VPSVCFLVPPPNQEAQEAV-TRLEAQHQALVTLWHQLHVDMKSLLAWQ 924
Query: 1608 EEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
+R + R + TL+ + QAL L +++ + Q A G PE +
Sbjct: 925 SLRRDVQLIRSWSLATFRTLKPEEQRQALHS-LELHYQAFLRDSQDA----GGFGPEDRL 979
Query: 1668 VVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGED 1727
+ + Q+L + ++ + R + E +D++ L + + L D
Sbjct: 980 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1039
Query: 1728 PEHALHLCTKFAKFQH-QVEMGSQRVAACRLLAES----LLERGHSAGPMVR-------- 1774
E A + A+ Q Q E+ RL AE+ L A P +R
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
Query: 1775 --QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVAR- 1831
++ + L + E + + E LR H E L + Q +LP A
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE---EQLKEAQAVPATLPELEATK 1156
Query: 1832 -DLCGLEAQLRSHQ----GLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
L L AQ + Q L EL G + + L + G + ++R +
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-----EVERWRERVAQL 1211
Query: 1887 TQAWAVLQRRMEQRRAQLER-ARLLARFRTAVRDYASWA--ARVRQDLQVEESSQEPSSG 1943
+ W + + + R+ +LE+ R L +R + +W AR RQ+ + +
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271
Query: 1944 PLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-----------------AGTPTKE-- 1984
+L Q L E+E + ++ + +Q + A +P K+
Sbjct: 1272 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1331
Query: 1985 --------VQE---------ELRALQDQRDQ-VYQTWARKQERLQAEQQEQLFLRECGRL 2026
+QE EL L Q + + +T R +E + +Q++ RE RL
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE--RL 1389
Query: 2027 EEILAAQE-----VSLKTSALGSSVEEVEQLIRK--HEVFLKVLTAQD--KKEAALRERL 2077
E+ AA E A + E ++L ++ EV + A D +++ +++E L
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQA 2132
+ LR+ + +Q + R E AE + + + AT+ AE +QA
Sbjct: 1450 QQLRQSSEAE-----IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEV 2191
+ +E +++ + L + E++ + EV + K EA A+ RA
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA--- 1561
Query: 2192 SQRLQGLRKHWED----LRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGD 2247
Q L+ LR E+ LRQA R ++++ LE QR AEA +Q K
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVA---LETAQRS--AEAELQSKRASF---- 1612
Query: 2248 LGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQL 2307
E QL R L+E + V A +R ++ Q + + E + +R +
Sbjct: 1613 ----AEKTAQLERSLQE-------EHVAVAQLREEAERRAQ-QQAEAERAREEAERELE- 1659
Query: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSR--------ELDNVTKR--------IQEKEAL 2351
RW LR + Q E + L++ E + +R ++++E
Sbjct: 1660 --RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717
Query: 2352 IQALDCGKDLE---SVQRLLRKHE--ELEREVHPIQAQVESLEREVGRLCQRSPEAAHGL 2406
Q L+ + L + QRL + E L E + Q + LE E+ RL + + A
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 2407 RHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQA---MLQELLVSAQRLRAQM 2458
+ + E+A E L S+A+ E+ ++ Q+L+A +EL A RLRA
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1837
Query: 2459 DTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
+ + R E A R E + AE + + ++ + L + +R++
Sbjct: 1838 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1897
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG-LWDPLAP 2575
+ LE +H+ +++ L QL +S ++ER ED+L + + +
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956
Query: 2576 MEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFR 2634
++ K + +LE++ G+I S E T R Q A+ + R+EA R
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 2635 QAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAMLPAQLQKQQNFQA 2693
+ E RQ +A L++ + + A + E + L E + AQ Q+ QA
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 2694 ELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACE 2753
E A Q+ ++E Q+ LQ + ++ E E ++ A++Q E
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------ARVQAERE 2130
Query: 2754 ALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLG 2813
A + RR +EE E + E + +A QA E L + E EAA +A QA
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 2814 QAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMA 2872
QA E H A+ Q ++ Q +LR L+E ++LL DEE+
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD---HQKNLL-------DEELQ 2237
Query: 2873 WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
++ + AA Q +E E+ S
Sbjct: 2238 RLKAEATEAA---------------RQRSQVEEELFS----------------------- 2259
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDM 2992
RVQ E + R EA R L+L+ Q+FL E E +AE L
Sbjct: 2260 ----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS---- 2311
Query: 2993 GHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAH 3052
A A LR+L E L Q AL E + ++QAV+EA
Sbjct: 2312 --VAAQEAARLRQLAE------------EDLAQQRALAEK-------MLKEKMQAVQEA- 2349
Query: 3053 AELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
R +A LQ+Q +L Q + L D + E+Q + + LE +
Sbjct: 2350 ----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER------ 2399
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+++++ +A+ LR A+ SR +A E Q + + E
Sbjct: 2400 ---QRQLEMSAEAERLKLR-----------------VAEMSRAQARAEEDAQRFRKQAEE 2439
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKE 3232
+ ++H + A QEK L V+TL+ Q ++ + + E + +
Sbjct: 2440 I--GEKLHRTELAT-------QEKVTL------------VQTLEIQRQQSDHDAERLREA 2478
Query: 3233 VARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQEL- 3291
+A L+ E K+Q+ LQ K++E Q Q L Q L
Sbjct: 2479 IAELEREK--------------EKLQQEAKLLQLKSEE-----MQTVQQEQLLQETQALQ 2519
Query: 3292 LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR-ECRLQAQDLRQEGQQLV--- 3346
++ E+ L E E + A EQL Q++R E + Q Q + QE Q+LV
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579
Query: 3347 DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAE 3398
+ + E E ++ + LQ+LE+ + + AE Q+LR++L+ E
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE--NQRLREQLQLLE 2629
Score = 108 bits (269), Expect = 1e-22
Identities = 292/1352 (21%), Positives = 505/1352 (37%), Gaps = 272/1352 (20%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + +A++E + G+L
Sbjct: 550 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 609
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH-------------------- 2435
SP R + + +L + ++ R +L++LH
Sbjct: 610 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 666
Query: 2436 --------------QAQKLQAMLQELLVSAQRLRAQMDTSPAP-RSPVEARRMLEEHQEC 2480
+ + A+++EL + ++++ + R AR +E Q
Sbjct: 667 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 726
Query: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQ---------------ELSS 2525
SW + + A F SD+R+ L++ ++
Sbjct: 727 LQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTR 786
Query: 2526 LEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKM 2585
LE Q+ Q + +Q E + LS + K + + + + P+ PLL
Sbjct: 787 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH----PMRGRLPLLAVCDY 842
Query: 2586 LEWDLEVQAGKISALEATARGLH--------------------QGGHPEAQSALGRCQAM 2625
+ ++ V G L A+ H + EAQ A+ R +A
Sbjct: 843 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 902
Query: 2626 -----------------LLRKEALFRQ---------AGTRRHRLEELRQL--------QA 2651
LL ++L R A R + EE RQ QA
Sbjct: 903 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 962
Query: 2652 FLQDSQEVAAWLREKNLVA-----------------LEEGLLDTA--------------- 2679
FL+DSQ+ + E L+A LE+G + +
Sbjct: 963 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1022
Query: 2680 ------------MLP----------AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
LP ++ +QQ QAE++ L E +++L
Sbjct: 1023 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
Query: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR- 2776
P+ A R EL G+L+ L+K + R + E L E +L+
Sbjct: 1083 PSPAAPTLR-SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1141
Query: 2777 APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE- 2830
A V LP + + ++L A + + +AL + + G L Q DVE
Sbjct: 1142 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1201
Query: 2831 ----EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRD-ADEEMAWVQ---------E 2876
E+ +LL+R++++ R+ LE L+++R+ AD AW+Q +
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 2877 KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVA 2936
+PLA +Q AVR Q Q L E+ H G K+ + FA +
Sbjct: 1262 AMPLADSQ-------AVREQLRQEQALLEEIERH----------GEKVEECQRFAKQYIN 1304
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
A ++ E + +A+ L A A++ +++GS + +V
Sbjct: 1305 A-IKDYELQLVTYKAQ------LEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELT 1354
Query: 2997 EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELL 3056
T ++ + T R +E ERL + E + E L + + + EAHA+
Sbjct: 1355 TLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 3057 RRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+AE LQ+++Q + RE +DA ++ E Q Q E
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------------- 1457
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD------QAIKART 3170
A++ A + A ER R I+ R ++EA + QA++AR
Sbjct: 1458 --------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509
Query: 3171 ENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
E A + Q+ A L+ ++Q+++ K + S V+ + R +R L+A+E
Sbjct: 1510 EEAEA--QKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALE 1566
Query: 3231 KEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQ-ERGQWLAQAAQGHAFLGRC- 3288
+ RLQ E +L A +VQ A T Q A+ E A A+ A L R
Sbjct: 1567 E--LRLQAEEAE-RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 3289 -QELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQD---LRQEGQQ 3344
+E +A AQ R+E +E A+ A AE+ EE +E+ +L+A + LR + ++
Sbjct: 1624 QEEHVAVAQLREE---AERRAQQQAEAER---AREEAERELERWQLKANEALRLRLQAEE 1677
Query: 3345 LVDNSHFMSAEVTECLQEL--EGRLQELEEAWALRWQRCAESWGLQKLRQRLE-QAEAWL 3401
+ AE + +E E R + E A+R + AE L+K RQ E A+ L
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRL 1736
Query: 3402 ACWEGLL-LKPDYGHSVSDVELLLHRHQDLEKLLAA----QEEKFAQMQKTEMEQELLLQ 3456
A + L+ L+ + +LL L++ AA ++E A++ K E E+LL
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796
Query: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAE 3488
+ + S+ + R G +LAE
Sbjct: 1797 SKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Score = 105 bits (262), Expect = 8e-22
Identities = 296/1237 (23%), Positives = 485/1237 (39%), Gaps = 178/1237 (14%)
Query: 277 EQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLF 336
E+ +L RW + L R + + + L A + +E ++RG AE
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711
Query: 337 RLQTALQAQNRRPFLPHEGLGLA------ELSQCWAGLEWAEAARSQALQQRLLQLQRLE 390
R + + + + EG EL + A E E R Q L++ L +LQR
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR-QLLEEELARLQREA 1770
Query: 391 TLARRFQHKAALRESFLKDAEQVL--DQARAPPASLATVEAAVQRLGMLEAGILPQEGRF 448
A + + + + ++ +VL +ARA S +T E + QRL EA + GRF
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---EA----EAGRF 1823
Query: 449 QALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQR---KQVADMQAVLSLLQ 505
+ LAE A LR + A+ A+RQ ++ Q + +R +++A + L
Sbjct: 1824 RELAEEAARLR-----ALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKT 1877
Query: 506 EVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH-LAQQTAEL 564
E E A + E E R +LAE +R LE Q + H A + LAQ
Sbjct: 1878 EAEIALKEKEAENERLR------RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKAS 1929
Query: 565 DSSLGTSVEVLQAKARTLAQLQQSLVALV----RARRALLEQTLQRAEFLRNCEE----- 615
DS L +++ R Q+++ ++AL +A E L+ N E+
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1989
Query: 616 EEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRR--GRDLSAR 673
E+A L+ QR A R + +QK A E E R + ++ V R + AR
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2049
Query: 674 RPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSL 733
R + + E A +Q + Q R+ + A V Q E L++ +S L
Sbjct: 2050 RLRERAEQ-ESARQLQLAQEAAQKRL--QAEEKAHAFAVQQ---KEQELQQTLQQEQSVL 2103
Query: 734 E--RASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
+ R + AAE V+ ER A R++EE R + +
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREA---AQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
E LR A A + A+ + + QT +Q + L L
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL-- 2218
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
R +LEE + Q LL E+ +LK
Sbjct: 2219 --RLQLEET-----------------DHQKNLLDE--------ELQRLK----------- 2240
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL 971
AE + +A Q R + ++ Q EELS+ ++EA R A+ L FL
Sbjct: 2241 ----AEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENR--ALILRDKDNTQRFL 2293
Query: 972 QECGPTQVQLRDVLLQLE-ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
QE Q+ + +L A Q + LAQ++ L + +Q+V
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
Query: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE-TQARQSFLQ--ESQQLLLWAESVQ 1087
AE++ LQ Q E Q +++QE Q A++ AE TQ Q L+ +QL + AE+ +
Sbjct: 2354 --AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 1088 AQLRSKEVSVDVA----SAQRLLREHQDLLEEIH----LWQERL---QQLDAQSQP---- 1132
+LR E+S A AQR ++ +++ E++H QE++ Q L+ Q Q
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 1133 -------MAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK-FGREVDG 1184
+A L+ + +++ ++L + +E++ + Q++Q LQE LQ+ F E D
Sbjct: 2472 AERLREAIAELE-REKEKLQQEAKLLQLKSEEMQTV--QQEQLLQETQALQQSFLSEKDS 2528
Query: 1185 FTATCAN-HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Q L+ L +D E Q E R + + L A E+ + Q
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMA- 1302
H A VR + + LQ +QRR+Q L E Q + E +Q +EE+ A
Sbjct: 2587 HEAEEGVRRKQEE-------LQQLEQQRRQQ---EELLAEENQRLREQLQLLEEQHRAAL 2636
Query: 1303 AHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGL 1362
AH E S++ AT+ GR+ L P + + + GL
Sbjct: 2637 AHS--------------EEVTASQVAATKTLPN-----GRDALD-GPAAEAEPEHSFDGL 2676
Query: 1363 RSKWEALNRKMTERG----DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
R K A +++ E G +ELQ+ Q + +L ++ L+G +SS G L++
Sbjct: 2677 RRKVSA--QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKA 2732
Query: 1419 SQRLQKRHQQLESESRTLAAKMAAL-ASMAHGMAASP 1454
+ + L+ + + + L A A G P
Sbjct: 2733 TNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2769
Score = 67.0 bits (162), Expect = 3e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 371 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 425
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 426 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 485
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 486 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 542
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 543 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 595
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 596 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 653
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 654 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 713
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 714 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 773
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 774 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 828
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 829 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 888
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 949 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1008
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 1009 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1064
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1065 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1181
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 1182 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1233
Query: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1289
Query: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 1350 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1409
Query: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1461
Query: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 1462 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 3446 KTEMEQELL 3454
+ + E E L
Sbjct: 1518 QAQEEAERL 1526
Score = 53.5 bits (127), Expect = 4e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 305 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 365 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 420
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 477
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 478 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 537
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 538 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 597
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 598 KIERARSDEGQL 609
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 346 bits (887), Expect = 3e-94
Identities = 203/553 (36%), Positives = 310/553 (56%), Gaps = 22/553 (3%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + +G+ L+ LLE+ISGE LP P RG++R H
Sbjct: 38 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFH 95
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL ++ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 96 KIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 151
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVNI +F SW DGLG ALIH HRPDL+DY L D
Sbjct: 152 -----SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKD 206
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
P+ N+ A +AE+ L I ++LD ED+ +PDER+IMTYVS +YH + Q +T
Sbjct: 207 DPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAA 266
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L +YE+L ++LL WI LE R ++ AM++ L F +
Sbjct: 267 NRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDY 326
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R + KPP++Q++ E LQT L+ NR F+P EG +++++ W LE AE
Sbjct: 327 RRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE 386
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L + +L+RLE LA +F+ KA+ E++ EQ+L Q ASL V A +++
Sbjct: 387 EWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEA 446
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E+ + + R + +A IA L + YH +V R +++ +W RL Q +R+ +
Sbjct: 447 FESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALER 506
Query: 497 MQAVLSLLQEVEAA--------SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQV- 547
M+ +L + ++ ++ +E E + + E+ L+ H+ +A +
Sbjct: 507 MEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566
Query: 548 SAHGAHVSHLAQQ 560
A G S +A Q
Sbjct: 567 EADGERQSIMAIQ 579
Score = 56.2 bits (134), Expect = 6e-07
Identities = 68/307 (22%), Positives = 125/307 (40%), Gaps = 28/307 (9%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852
Q + + ++ Q + + AF+ + D+ +RL Q K E L E R
Sbjct: 336 QEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRR 395
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY-GQSLSAVRHLQEQHQNLESEMSSHE 2911
L KF + A W K + +DY SL+ VR L +H+ ES++++H+
Sbjct: 396 LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + + A V R Q++ L +RR L++ ++ + +
Sbjct: 456 DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
Query: 2972 EL--------LEAGSWLAERGHVLDSEDM--GHSAEATQAL----------LRRLEATKR 3011
+L +W+ G + D +DM HS E Q+L L + ++
Sbjct: 516 QLHLEFAKRAAPFNNWM--EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
Query: 3012 DLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL- 3070
+ A +E++ Q+ + S NP S + +L+ + +L+ R LQE+L
Sbjct: 574 SIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLV---PIRDQSLQEELA 630
Query: 3071 QLHQLER 3077
+ H ER
Sbjct: 631 RQHANER 637
Score = 53.9 bits (128), Expect = 3e-06
Identities = 65/280 (23%), Positives = 120/280 (42%), Gaps = 36/280 (12%)
Query: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEE-ILAAQEVSLKTSALGSSVEE 2048
+Q ++ Y+ W R+ ERL E + F ++ E +++ L+ +S+ E
Sbjct: 379 EQAEKGYEEWLLNEIRRLERL--EHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
Query: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102
V L+RKHE F L A QD+ E AA+ + L L V DR + + R+ L
Sbjct: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
Query: 2103 AESRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154
+ R AL L F + A +W++ + L++ + + +
Sbjct: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
Query: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQ----RLQGLRKHWEDLRQ 2207
H+ F+A E + + ++ + E ++ + R + + LR W+ ++Q
Sbjct: 557 AHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQ 616
Query: 2208 AMALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239
+ +R Q L++ R++ E L+R A+A WIQ K
Sbjct: 617 LVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK 656
Score = 53.1 bits (126), Expect = 5e-06
Identities = 69/294 (23%), Positives = 116/294 (39%), Gaps = 55/294 (18%)
Query: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAW--------LHLDNLGEDVR 1206
Q L+ + ++WL E L++ + F + H+ W L D +
Sbjct: 376 QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLT 435
Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
E +LL++H F L+ R E + A ++L + + A V ++ Q I QW RL G
Sbjct: 436 EVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL-G 494
Query: 1267 RSEQRRRQLLASLQ-------------------LQEWKQDVAELMQWM-------EEKGL 1300
Q+RR+ L ++ W + E +Q M E + L
Sbjct: 495 TLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSL 554
Query: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVE-ALQQVGRELLSRRPCGQEDIQTRL 1359
+ AHE A TL + ++A + VE +Q + S P +
Sbjct: 555 ITAHEQFKA------TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYS----TVTM 604
Query: 1360 QGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1413
LR+KW+ + + + R L QE+L R Q A E+L + + A Q++ G
Sbjct: 605 DELRTKWDKVKQLVPIRDQSL-----QEELAR--QHANERLRR-QFAAQANAIG 650
Score = 50.4 bits (119), Expect = 3e-05
Identities = 54/232 (23%), Positives = 98/232 (42%), Gaps = 33/232 (14%)
Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
E L+ + W++ + + + + + LE R++R V + C I+
Sbjct: 292 ELLEWIRRTIPWLENRTPEKTMQAMQKKLED-------FRDYRRKHKPPKVQEKCQLEIN 344
Query: 2284 DLSLQLKNRD-------PEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
+LQ K R P E K++ S + W Y++ L EI L R
Sbjct: 345 FNTLQTKLRISNRPAFMPSEGKMV----SDIAGAWQRLEQAEKGYEEWLLN--EIRRLER 398
Query: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384
L+++ ++ ++K + + GK+ L V+ LLRKHE E ++ Q +
Sbjct: 399 -LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
Query: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436
VE + L + A + R Q++ + W +L + QKRREAL+ + +
Sbjct: 458 VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
Score = 48.5 bits (114), Expect = 1e-04
Identities = 78/400 (19%), Positives = 163/400 (40%), Gaps = 56/400 (14%)
Query: 1013 LERRVHFLQSVVVKVEEPGYAESQ-----PLQGQVETLQGLLKQVQEQVAQRARRQAETQ 1067
LE + LQ+ + P + S+ + G + L+ K +E + RR +
Sbjct: 341 LEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE 400
Query: 1068 -ARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+ F Q++ WA + L K+ S + + LLR+H+ ++ Q+R++Q
Sbjct: 401 HLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVD-- 1183
+ A +Q + LD D+ V + + + Q L L ++R++ L+ ++K +D
Sbjct: 461 IAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQL 517
Query: 1184 --GFTATCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA 1234
F A W+ +++L + + E SL+ H +F L +++ A
Sbjct: 518 HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMA 577
Query: 1235 ---HGEKLVQ-------SQHPAAHTVREQL---------------QSIQAQWTRLQGRSE 1269
EK++Q S +P + ++L QS+Q + R Q +E
Sbjct: 578 IQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR-QHANE 636
Query: 1270 QRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLA 1329
+ RRQ A + +Q E+ ++ + +GA + + LK++ E ++
Sbjct: 637 RLRRQFAAQANA------IGPWIQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIIN 687
Query: 1330 TRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
+ +++ L+ + + + ++ +R WE L
Sbjct: 688 YKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELL 727
Score = 47.8 bits (112), Expect = 2e-04
Identities = 72/398 (18%), Positives = 146/398 (36%), Gaps = 38/398 (9%)
Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557
+ W+ P + + + L + RKHK +V+ K L + L S P
Sbjct: 301 IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQT--KLRISNRP 358
Query: 1558 QAQHIV-EQCQELEGHWAELERACEARAQCLQQAV--------TFQQYFLDVSELEGWVE 1608
+ ++ G W LE+A + + L + +++ S E W
Sbjct: 359 AFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAY 418
Query: 1609 EKRPLVSSRDYGRDEAATLR-LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQR 1667
K ++ +DY +R L+ KH+A + +LA + +E++ AQ L + +
Sbjct: 419 GKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVN 478
Query: 1668 VVQ---------ERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717
V +RL + +E ++ LE +LH EF + A W+ +
Sbjct: 479 VNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMED 538
Query: 1718 AKGGESLGEDPEHALHLCTKFAKFQ---HQVEMGSQRVAACRLLAESLLE----RGHSAG 1770
+ + E L T +F+ + + Q + A + E +++ R S+
Sbjct: 539 LQ-DMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSN 597
Query: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822
P +L+T W ++ +L R +L++ + L +Q K
Sbjct: 598 PYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM 657
Query: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
+ + + LE Q+ + E ++ + + +L
Sbjct: 658 EEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKL 695
Score = 46.2 bits (108), Expect = 6e-04
Identities = 71/322 (22%), Positives = 130/322 (40%), Gaps = 36/322 (11%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE-EWLLNEIRR 395
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
+ LE + F E W KE L + L + LL KH+ E DL
Sbjct: 396 LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL----- 2649
++ + A A+ L++ + +A + RCQ + + + L RR LE + +L
Sbjct: 456 DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
Query: 2650 QAFLQDSQEVAA---WLREKNLVALEEGLLDTAM--LPAQLQKQQNFQA---ELDASMHQ 2701
Q L+ ++ A W+ E + L++ + ++ + + + + F+A E D
Sbjct: 516 QLHLEFAKRAAPFNNWM-EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
Query: 2702 QQELQREGQRLLQ-------GGHPASEAIQERLEELGALWGE------LQDNSQKKVAKL 2748
+Q E ++++Q +P S ++EL W + ++D S ++
Sbjct: 575 IMAIQNEVEKVIQSYNIRISSSNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELAR 631
Query: 2749 QKACEALRLRRSMEELENWLEP 2770
Q A E RLRR N + P
Sbjct: 632 QHANE--RLRRQFAAQANAIGP 651
Score = 43.9 bits (102), Expect = 0.003
Identities = 61/273 (22%), Positives = 106/273 (38%), Gaps = 30/273 (10%)
Query: 3153 SRIEAAWERLDQAIKARTENL--------AAAHEVHSFQQAAA--ELQGRMQEKTALMKG 3202
S I AW+RL+QA K E L H F+Q A+ E +E+ L K
Sbjct: 369 SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428
Query: 3203 EDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQL--HPA--APGGLAKVQ 3258
+ SL+ VR L ++H E +L A + V ++ A L +L H A K+
Sbjct: 429 YESA-SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
Query: 3259 EAWATLQAKAQERGQWLAQAA-------QGH-AFLGRCQELLAWAQERQELASSEELAED 3310
+ W L Q+R + L + Q H F R W + E +
Sbjct: 488 DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
Query: 3311 VAGAEQLLGQHEELGQEIREC---RLQAQDLRQEGQQLVDNSHFMSAE----VTECLQEL 3363
+ + L+ HE+ + E R ++ E ++++ + + + T + EL
Sbjct: 548 IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607
Query: 3364 EGRLQELEEAWALRWQRCAESWGLQKLRQRLEQ 3396
+ ++++ +R Q E Q +RL +
Sbjct: 608 RTKWDKVKQLVPIRDQSLQEELARQHANERLRR 640
Score = 41.2 bits (95), Expect = 0.019
Identities = 36/131 (27%), Positives = 62/131 (47%), Gaps = 11/131 (8%)
Query: 3330 ECRLQAQ-DLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEA------WALRWQRCA 3382
+C+L+ + Q ++ + FM +E + + ++ G Q LE+A W L R
Sbjct: 338 KCQLEINFNTLQTKLRISNRPAFMPSE-GKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRL 396
Query: 3383 ESWG--LQKLRQRLEQAEAWLACWEGLLLKPDY-GHSVSDVELLLHRHQDLEKLLAAQEE 3439
E +K RQ+ E W E +LL+ DY S+++V LL +H+ E LAA ++
Sbjct: 397 ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQD 456
Query: 3440 KFAQMQKTEME 3450
+ Q+ E
Sbjct: 457 RVEQIAAIAQE 467
Score = 40.8 bits (94), Expect = 0.025
Identities = 68/353 (19%), Positives = 148/353 (41%), Gaps = 65/353 (18%)
Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
+D R +R K + QLE TL K M + M +A + LE+
Sbjct: 321 EDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQ 380
Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
+K +RRLE L+ HLA + Q ++ H+ ++ ++
Sbjct: 381 AEKGYEEWLLNEIRRLERLE-HLAEKFRQKAST---HETWAYGKEQILLQKDY----ESA 432
Query: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
S TE ++L RKH+ + ++ AHQ +V+++ + + L + A ++ ++CQ++
Sbjct: 433 SLTE----VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488
Query: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
W L + R + L++ + +D LE + + P + + ++ + +++
Sbjct: 489 QWDRLGTLTQKRREALERMEKLLE-TIDQLHLE-FAKRAAPFNNWMEGAMEDLQDMFIVH 546
Query: 1632 KHQALQEELAI---YWSSMEELDQTAQTLTGPEVPEQQRVVQ-----------------E 1671
+ +Q + + +++ E D Q++ + E ++V+Q +
Sbjct: 547 SIEEIQSLITAHEQFKATLPEADGERQSIMAIQ-NEVEKVIQSYNIRISSSNPYSTVTMD 605
Query: 1672 RLREQLRALQELAATRDRELEGTL-RLH-------EFLREAEDLQGWLASQKQ 1716
LR + +++L RD+ L+ L R H +F +A + W+ ++ +
Sbjct: 606 ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKME 658
Score = 40.4 bits (93), Expect = 0.032
Identities = 62/334 (18%), Positives = 131/334 (39%), Gaps = 45/334 (13%)
Query: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPA---RSTACGQQ-- 529
++ WQRL Q +G + + L+ ++ +E H E+ ++ A + A G++
Sbjct: 370 DIAGAWQRLEQAEKGYEEWL------LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQI 423
Query: 530 ----------LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKA 579
L EV LL++H+ E+ ++AH V +A EL+ + +
Sbjct: 424 LLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRC 483
Query: 580 RTLAQLQQSLVALVRARRALLE------QTLQR--AEFLRNCEEEEAWLKECGQRVGNAA 631
+ + L L + RR LE +T+ + EF + W++ + + +
Sbjct: 484 QKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMF 543
Query: 632 LGRDLSQIAGALQKHKAL-----EAEVHRHQAVCV--DLVRRGRDLSARRPPTQPDPGER 684
+ + +I + H+ EA+ R + + ++ + + + R + P
Sbjct: 544 IVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVT 603
Query: 685 AEAVQGGWQLLQTRVVGRGARLQTAL--------LVLQYFADAAEAASWLRERRSSLERA 736
+ ++ W ++ V R LQ L L Q+ A A W++ + + R+
Sbjct: 604 MDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARS 663
Query: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
S Q A E + + + E + + + +LE
Sbjct: 664 SI-QITGALEDQMNQLKQYEHNIINYKNNIDKLE 696
Score = 37.0 bits (84), Expect = 0.36
Identities = 80/432 (18%), Positives = 159/432 (36%), Gaps = 56/432 (12%)
Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN------ 1631
R C+ A + ++Y SEL W+ P + +R + A + +
Sbjct: 268 RICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYR 327
Query: 1632 -KHQA--LQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678
KH+ +QE +L I ++++ QT ++ +P + ++V + RL + +
Sbjct: 328 RKHKPPKVQEKCQLEINFNTL----QTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEK 383
Query: 1679 ALQELAATRDRELEGTLRLHE-FLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+E R LE L E F ++A + W ++Q + L K
Sbjct: 384 GYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRK 443
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
F+ + RV +A+ L E + V R Q + W L LTQ R A
Sbjct: 444 HEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREA 503
Query: 1798 LRDTETTLRVHRDLLEVLTQVQ---EKATSLPNN-------------VARDLCGLEAQLR 1841
L E LLE + Q+ K + NN + + +++ +
Sbjct: 504 LERME-------KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901
+H+ + L + + Q ++ V+K+ +Q ++ + M++ R
Sbjct: 557 AHEQFKATLPEADGERQSIMAIQNEVEKV--------IQSYNIRISSSNPYSTVTMDELR 608
Query: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP-LKLSAHQWLRAELEAR 1960
+ ++ + L R + L+ + ++Q + GP ++ + R+ ++
Sbjct: 609 TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT 668
Query: 1961 EKLWQQATQLGQ 1972
L Q QL Q
Sbjct: 669 GALEDQMNQLKQ 680
Score = 36.6 bits (83), Expect = 0.47
Identities = 45/238 (18%), Positives = 95/238 (39%), Gaps = 8/238 (3%)
Query: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
G Q+R L ++ L+ + L ++ + A W+ L+ S+ ++
Sbjct: 494 GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553
Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--PFLPHEGLGLAELSQCWA 366
L+ A F+ P +R + A+ ++ +Q+ N R P+ + + EL W
Sbjct: 554 LITAHEQFKAT-LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWD 612
Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
++ R Q+LQ+ L + E L R+F +A ++++ + + AR+
Sbjct: 613 KVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEI--ARSSIQITGA 670
Query: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLL 484
+E + +L E I+ + L ++++ E + V W+ LL
Sbjct: 671 LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
Score = 33.1 bits (74), Expect = 5.2
Identities = 61/336 (18%), Positives = 134/336 (39%), Gaps = 37/336 (11%)
Query: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIE-VELRAPTVGQA 2783
+RLE+ + E N +++ +L+ E R + S E W E + L+ +
Sbjct: 376 QRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHE--TWAYGKEQILLQKDYESAS 433
Query: 2784 LPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843
L V LL E+ + + E + AQ + A +V ++ +++ ++ L
Sbjct: 434 LTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRL 493
Query: 2844 REPLQERRTALEARSLLLKFFRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRH 2895
Q+RR ALE LL+ E A W++ + S+ ++
Sbjct: 494 GTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQS 553
Query: 2896 LQEQHQNL-----------ESEMSSHEALTRVVLGTGYKLVQAGHFAA---HEVAARVQQ 2941
L H+ +S M+ + +V+ ++ + ++ E+ + +
Sbjct: 554 LITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDK 613
Query: 2942 LEKAMAHLRAEAARRRLLLQQAQE--AQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EA 2998
+ K + +R ++ + L Q A E +QF + G W+ + E++ S+ +
Sbjct: 614 V-KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNK-----MEEIARSSIQI 667
Query: 2999 TQAL---LRRLEATKRDLEAFSPRIERLQQTAALLE 3031
T AL + +L+ + ++ + I++L+ L++
Sbjct: 668 TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQ 703
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 345 bits (885), Expect = 5e-94
Identities = 762/3642 (20%), Positives = 1389/3642 (38%), Gaps = 526/3642 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKW+N + I +LY +L DG +L+ LLE++SG LP +GR+R H
Sbjct: 78 RVQKKTFTKWVNKHLM--KVRKHINDLYEDLRDGHNLISLLEVLSGIKLPR-EKGRMRFH 134
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL FL+ + V + I ++I DG+ L LGLIW IIL FQIS I + E
Sbjct: 135 RLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDM 194
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
SA KE LL+W Q+ TA YT + T+FS WSDG FNALIH +RPDL+D ++
Sbjct: 195 SA-----KEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQ 249
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
NL AF VAE+ LG+ +LLD EDV PDE+S++TYVS Y ++ +G
Sbjct: 250 SNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEG-- 306
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
+ E + +Y+ V L+ WI + + + + FP + ++ L + F+
Sbjct: 307 ------ISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK 360
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
E + +++G E L L+ ++ R LP +G ++ + W L R +
Sbjct: 361 ETEILAKEREKGRIEELYKLLEVWIEF--GRIKLP-QGYHPNDVEEEWGKLIIEMLEREK 417
Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
+L+ + +L+ L +A + Q+ A E L A+ L A S V+ + +
Sbjct: 418 SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ----------- 481
+ EG + L ILR E Y+ ++A R E VT+R +
Sbjct: 478 Q----ECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT 533
Query: 482 ---------RLLQHLQGQ--------------RKQV--ADMQAVLSL-----LQEVEAAS 511
HL+ + RK + A++ A+ S L+ V
Sbjct: 534 SLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELL 593
Query: 512 HQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTS 571
+EE+Q G L V L+ + V G+ V ++ + TS
Sbjct: 594 SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS 653
Query: 572 VEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAA 631
A TL +L+ L + +F+ E WL E +
Sbjct: 654 Y------AETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707
Query: 632 LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGG 691
+ S I+ L E+ Q V L LS P + + AVQ
Sbjct: 708 WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767
Query: 692 WQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA-SCGQDQAAAETLLR 750
Q ++ + ++ Q+F+DA E S+LR + S++R SC + + +
Sbjct: 768 LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLS----- 822
Query: 751 RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP--PGESLRNPGPWSEASCH 808
RLE +L+ E +L + + ++ L P P L+N
Sbjct: 823 ---RLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKN---------- 869
Query: 809 PGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCS 868
+++ A D TI + + + +D S R ++ EAM
Sbjct: 870 -------TISVKAVCDYRQIEITICKNDECVLED-NSQRTKWKVISPTGNEAMV------ 915
Query: 869 SCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS-------- 920
+V P D +E+ +++ +A+ L S
Sbjct: 916 -----------PSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLR 964
Query: 921 ---------SAEQLRQRYPGNSTQI----QRQQEELSQRWGQLEALKREKAVQLAHSVEV 967
+ E+LR PG QI Q E+ Q ++L VE
Sbjct: 965 KDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEA 1024
Query: 968 CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKV 1027
C + + + + +++++ E+T + +++ K + L R + Q VV ++
Sbjct: 1025 C---------KARFQHL---MKSMENEDKEETVAKMYISELKNIRL-RLEEYEQRVVKRI 1071
Query: 1028 EEPGYAESQPLQGQVETLQ-GLLKQVQEQVAQ-RARRQAETQARQSFLQES--------- 1076
+ + + Q L+ + QE + Q R+ A + SFL +S
Sbjct: 1072 QSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTL 1131
Query: 1077 -QQLLLWAESVQAQLRSKEVSVD-VASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
+L L E + V ++ + + ++R QD + ++ +L Q + ++
Sbjct: 1132 RSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLS 1191
Query: 1135 ALDC---------PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDG 1184
AL+ D ++ + VL ++ + KV+ EQ + E L+L+++ + G
Sbjct: 1192 ALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY--QEKG 1249
Query: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHRE-FGRLLSTLGPRAEALRAHGEKLVQSQ 1243
H+ L+ ++ +L +R G L+ + E A E + Q
Sbjct: 1250 SQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWI----EETTAQQEMMKPGQ 1305
Query: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-----MQWMEEK 1298
+ + EQL +Q T L E+ + +L Q Q++ Q + + +Q M K
Sbjct: 1306 AEDSRVLSEQL----SQQTALFAEIERNQTKL---DQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELL-----------ATRRHVEALQQVGRELLSR 1347
+ + + S +R + L +A E + T +HV+ + R L
Sbjct: 1359 AFVESQQKSPGKRR--RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEE 1416
Query: 1348 RPCGQEDIQTRLQGLRS--------------------------------KWEALNRKMTE 1375
+E+ Q ++ ++ + + L+ ++T
Sbjct: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTT 1476
Query: 1376 RGDELQQAGQQEQLL----------RQLQDAKEQLEQLEGALQ-----SSETGQDLRSSQ 1420
+ +++ +A + Q+ ++ + EQL L A S+ Q L+S
Sbjct: 1477 KKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
Query: 1421 RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEE---TQKHLRRLELLQGHLAIR 1477
Q + L+ + T ++ L S G A + TQ+ L L+ Q L +
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWV-GQAERALAGHQGRTTQQDLSALQKNQSDL--K 1593
Query: 1478 GLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
LQ F + ++ E+ SP T +++ LQ E +
Sbjct: 1594 DLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVA 1653
Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYF 1597
Q +++ ++S A+ + E ++++ + + Q L +Q
Sbjct: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ-- 1711
Query: 1598 LDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN-------KHQAL----QEELAIYWSS 1646
L G EK L ++ Y A +L +HQ L Q + S+
Sbjct: 1712 -----LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 1766
Query: 1647 MEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELE--GTLR--LHEFLR 1702
LDQ LT PE+Q+++Q++L E A + EL+ TL+ L +FL+
Sbjct: 1767 QAFLDQHGHNLT----PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ 1822
Query: 1703 EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESL 1762
+ ++ + WL ++ + G PE L + F V + + + +
Sbjct: 1823 DHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882
Query: 1763 LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKA 1822
L D++ ++ E E ++ G+ ++D +D E T + K
Sbjct: 1883 L---------------DMENSFKEGKEPSEI-GNLVKDK------LKDATERYTALHSKC 1920
Query: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR 1882
T L +++ L S L+ + E +++LL PG V Q
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASD---PG-----VLQE 1972
Query: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
Q A T+ LQ + + + +E+ + +AR + + R V+E++
Sbjct: 1973 QLATTKQ---LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHR-----HVQETTDS--- 2021
Query: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQT 2002
LS Q L L R L Q+A Q VQE L +L +V Q
Sbjct: 2022 ---ILSHFQSLSYSLAERSSLLQKAIAQSQ-----------SVQESLESLLQSIGEVEQN 2067
Query: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS---------ALGSSVEEVEQ-- 2051
KQ + Q L +L++ +A Q+ SL+ + S+ V Q
Sbjct: 2068 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2127
Query: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALH 2111
L + F ++ Q +KE++L+ K L + + + L LQ+ M K
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLK---KLLPQAEMFEHLSGKLQQFMENK----------- 2173
Query: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVM 2170
S ++AS Q + I + QQ++E + D ++ L L E ++
Sbjct: 2174 -SRMLAS----GNQPDQDITHFFQQIQELNLEMEDQQENLDTL-------------EHLV 2215
Query: 2171 TSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-EFLQRV 2229
T ++ G AL H R+Q LRK + +L++ + R ++ + L EF + V
Sbjct: 2216 TELSSCGFALDLCQH------QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV 2269
Query: 2230 DLAEAWIQE-------KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSI 2282
+ W++E E M+ +L + +EH L+ L ++ S G V + +
Sbjct: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEH---LKSLLDDWA--SKGTLVEEINCKGT 2324
Query: 2283 SDLSLQLKNRDPEE---------------------------VKIICQRRSQLNNRWASFH 2315
S +L ++ P+ +I C S +N ++
Sbjct: 2325 SLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD-MSDVNLKYEKLG 2383
Query: 2316 GNLLRYQQQLEGAL-EIHVLSRELDNVTKRIQEKEALIQALDCGKD---LESVQRLLRKH 2371
G L Q+ L+ L + + +E ++V + ++ KE +++++D E+V+ +
Sbjct: 2384 GVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN 2443
Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSP--EAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
+ E+ +++ ++ + L P + A + Q+E+ W + R+
Sbjct: 2444 KAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR 2503
Query: 2430 ALD--ALHQA--QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELD 2485
L+ A H A Q ++ L+ L+ + + + P P ++ Q E +
Sbjct: 2504 QLEESASHLACFQAAESQLRPWLMEKELMMGVL--GPLSIDPNMLNAQKQQVQFMLKEFE 2561
Query: 2486 SWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-------HQLQLQ 2538
+ Q +LT S QV ++EL S+ W E Q+
Sbjct: 2562 ARRQQHEQLNEAAQGILTGPGDVSLSTSQV----QKELQSINQKWVELTDKLNSRSSQID 2617
Query: 2539 QAL----ELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQA 2594
QA+ + Q L + + R + S+ S P A ++ L + + DLE
Sbjct: 2618 QAIVKSTQYQELLQDLSEKVR-AVGQRLSVQSAISTQPEA-VKQQLEETSEIRSDLEQLD 2675
Query: 2595 GKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE-ELRQLQA 2651
++ + L G R + + L + L A R +RL+ L Q
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
Query: 2652 FLQDSQEVAAWLREKNLVALEEGLLDTAM--LPAQLQKQQNFQAELDASMHQQQELQREG 2709
F Q E+ WL +K + + + L +QLQ+ + FQ L+ + + EG
Sbjct: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 2795
Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKACE-ALRLRRSMEELEN 2766
+ LL P E +Q +L EL W EL + + ++L+ + A + + +E+L
Sbjct: 2796 ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 2855
Query: 2767 WLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
W+E + ++ V + L + + V+K+ E L A +
Sbjct: 2856 WIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 2915
Query: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA----DEEMAWVQEKL---- 2878
+ ++ + Q ++ E LQ + +LE + L+ F+++ ++++ + +L
Sbjct: 2916 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD 2975
Query: 2879 PLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAAR 2938
L + ++L +R QE Q LE ++ T+ ++ A H+
Sbjct: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL-LHQAEVA 3034
Query: 2939 VQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVL--------DSE 2990
Q+ + + + ++ + + QF + E S LA+ L D++
Sbjct: 3035 QQEFLEVKQRVNSGCV---MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3091
Query: 2991 DMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE 3050
+ E + L ++ K D+EA +LE + + +L+A+ +
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRH------MLEEEGTLDLLGLKRELEALNK 3145
Query: 3051 AHAELLRRAEARGHGLQEQLQLHQLERETL------LLDAWLTTKAATAESQDYGQDLEG 3104
+L R +AR QEQL+L E L DA + A A G ++E
Sbjct: 3146 QCGKLTERGKAR----QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201
Query: 3105 VKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPR--RYPHIQAQRSRIEAAWERL 3162
+ F F+KE Q K+ + L L + A + ++ I A W L
Sbjct: 3202 INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTL 3261
Query: 3163 DQAIKARTENL-AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQ-QQHR 3220
++ + R L A FQ A L + + L+ + + V Q Q+ +
Sbjct: 3262 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3321
Query: 3221 RLERELEAMEKEVARLQTEACRLGQLHPAA-----PGGLAKVQEAWATLQAKAQERGQWL 3275
L+R L+ + V LQ E R+ Q A G L ++ W L +KA R + L
Sbjct: 3322 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3381
Query: 3276 AQ----AAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
A Q H + L+ +++ LA+SE + A +Q + +H+ L ++I
Sbjct: 3382 EDILVLAKQFHETAEPISDFLSVTEKK--LANSEPVGTQTAKIQQQIIRHKALEEDIENH 3439
Query: 3332 RLQAQDLRQEGQQLVD-NSHFMSAEVTECLQELEGRLQELEE 3372
+ GQ L S ++E + L+ R E+++
Sbjct: 3440 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
Score = 219 bits (557), Expect = 5e-56
Identities = 479/2423 (19%), Positives = 963/2423 (39%), Gaps = 262/2423 (10%)
Query: 844 ESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKY- 901
+ L LA R RL+ A+A F EL+ WL+ + + P + LE +Q +
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
Query: 902 --ENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ--IQRQQEELSQRWGQLEALKREK 957
E F +L G + + + E L P + +Q Q EL W +L ++
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832
Query: 958 AVQLA-----------HSVEVCSFLQECGPTQVQLRDVL--LQLEALQPGSSEDTCHALQ 1004
+L H ++ ++++C +LR L +QLE+ S L
Sbjct: 2833 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA----MLN 2888
Query: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
+K+ +LE L S + A+ ++ + + + V E++ QA
Sbjct: 2889 EVEKRRSLLE----ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL------QA 2938
Query: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
+T + + Q ++ ++++ ++ + +++ A LE++ QE LQ
Sbjct: 2939 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 2998
Query: 1125 QLDAQSQPMAAL------DCPDSQEVPNTLR---VLGQQGQELKVLWEQRQQWLQEGLE- 1174
L+ Q + D PD + L V Q+ E+K ++ LE
Sbjct: 2999 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3058
Query: 1175 LQKFGREVDGFTATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
+ +F V + A+ L + +G D S ++ R F + L EA
Sbjct: 3059 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3118
Query: 1234 AHGEKLVQSQHPAAHT-VREQLQSIQAQWTRLQGRSEQRRRQL-------------LASL 1279
A +++ + ++ +L+++ Q +L R + R+ QL L L
Sbjct: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3178
Query: 1280 QLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
+ AE +QW+ + ++ L K + + + L + ++ +
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQ-------LADFKMFQKEQVDPLQMK--LQQVNG 3229
Query: 1340 VGRELLSR--RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA--------GQQEQL 1389
+G+ L+ + C + ++ ++ + ++W LN+K+ +R +LQ+A E L
Sbjct: 3230 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL 3289
Query: 1390 LRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHG 1449
L L D +E + + S + +++ + QK Q+L + + + A G
Sbjct: 3290 LSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG----G 3342
Query: 1450 MAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQ----ASVELHQFCHLSNMEL 1498
A A L + +K +LE L+ A R QL+ + + H+ + L
Sbjct: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402
Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
S + + + P T+ Q + R HK L+ +++ H V + + G+SL++ P
Sbjct: 3403 SVTEKKLANSEPVG-TQTAKIQQQIIR-HKALEEDIENHATDVHQAVKIGQSLSSLTSPA 3460
Query: 1559 AQHIV-EQCQELEGHWAELERACEARAQCLQQAVTFQQYF-LDVSELEGW---VEEKRPL 1613
Q ++ E+ L+ ++E++ C +A L QA++ + F D E+ W VE+K
Sbjct: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSS 3520
Query: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL 1673
V +D+ +D R H AL EE+ ++++ + Q L E+ ++QE+L
Sbjct: 3521 VFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
Query: 1674 REQLRALQELAATRD---RELEGTLRLH-EFLREAEDLQGWL--ASQKQAAKGGES-LGE 1726
++ T R LE +L +F E+L GWL ++ A GG+S GE
Sbjct: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 3638
Query: 1727 DPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD----LQT 1782
+ +FQ + + + V RL+ +++ E + +V R ++ L +
Sbjct: 3639 ----------QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 3688
Query: 1783 AWSELWEL-TQARGHALRDTETTLRVHRDL-------LEVLTQVQEKATSL-PNNVARDL 1833
+E ++L + G + + + ++ + L + + + K +L P + +D
Sbjct: 3689 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQ 3748
Query: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
AQL+ + +++ + + EL + C Q +Q++ +++ Q + +
Sbjct: 3749 T--TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806
Query: 1894 QRRMEQRRAQLERARLLA-RFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
+R A+LERA++L +F + + W +EE+ + P H+
Sbjct: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPW---------IEETRALIAQLPSPAIDHEQ 3857
Query: 1953 LRAELEAREKLWQQATQLGQQA--LLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERL 2010
LR + E +L + + LL G KE+ E + +++ Q K E +
Sbjct: 3858 LRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ-------KAENM 3910
Query: 2011 QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK-- 2068
A+ +E++ R E + + +++ + +E +E L + + + DK
Sbjct: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970
Query: 2069 ------KEAALR-ERL----------------------KTLRRPRVRDRLPILLQRRMRV 2099
K A + E+L K L ++D+L ++ +
Sbjct: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
Query: 2100 KELAESRGHALHASLLMAS---FTQAA--TQAEDWIQAWAQQLKEP-VPPGDLRDKLKPL 2153
K AE R L +A + AA T +D Q L+ P + P ++ +++
Sbjct: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-TQDIVHDLESPGIDPSIIKQQVEAA 4089
Query: 2154 LKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
+ + E HEE+ + + A EV + + + WE+L + R
Sbjct: 4090 ---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4146
Query: 2213 GQELEDRRNF-LEFLQRVDLAEAWIQEKEVKM-NVGDLGQDLEHCLQLRRRLREFRGNSA 2270
++LED +++ + W+ +K+ + +G DL ++EF+
Sbjct: 4147 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206
Query: 2271 GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL- 2329
+ + +L L+ K D + II + ++L + W + + Q +LEGAL
Sbjct: 4207 QQQIEMEKLNHQGELMLK-KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265
Query: 2330 EIHVLSRELDNVTKRIQEKEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
+ L+ + + E L+ A D + ++ L KH L+ +V QA VE++
Sbjct: 4266 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV 4325
Query: 2389 EREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAMLQE 2446
+ L + S + A LR R + + + W + + ++R + L + L QAQ + +++
Sbjct: 4326 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4385
Query: 2447 LLVSAQRLRAQMDTS-PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG 2505
L+ R+ +Q+ S P P AR L+ H E ++L + ++ + G+ +L +
Sbjct: 4386 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4445
Query: 2506 HPFSSDIR--QVLAGLEQELSSLEGAWQEHQLQLQQALELQL-FLSSVEKMERWLCSKED 2562
S + Q +A LEQ+ + +E + +L++AL L F +S+++ WL E
Sbjct: 4446 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 4505
Query: 2563 SLASEGLWDP----LAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSA 2618
SL + P L + + +HK+ ++ +I L+ T L +
Sbjct: 4506 SL---NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL 4562
Query: 2619 LGRCQAMLL-RKEALFRQAGTRRHRLEELRQ-LQAFLQDSQEVAAWLR--EKNLVALEEG 2674
+ + R E + +++ R L++ R+ + F + +++ WL E +L + E
Sbjct: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
Query: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
D + QL K + FQ L R G+ L + + E ++L
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE-----KTLLPEDSQKLDNFL 4677
Query: 2735 GELQDNSQ----KKVAKLQKACEAL----RLRRSMEELENWLEPIEVELRA--PTVGQAL 2784
GE++D K V + K EAL + +++ L +WL +E +L P G L
Sbjct: 4678 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD-L 4736
Query: 2785 PGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLR 2844
V L+ + + + K+ + L + + V+ Q + L R+ ++
Sbjct: 4737 DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 4796
Query: 2845 EPLQERRTALEARSLLLKFFRDADEEMA-WVQE-KLPLAAAQDYGQSLSAVRHLQEQHQN 2902
+ +++ LE + FRD + W+ E + L A++ L + H+
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKE 4856
Query: 2903 LESEMSSHEALTRVVLGTGYKLVQAGH-----FAAHEVAARVQQLEKAMAHLRAEAARRR 2957
++ + G ++ H H + + E+ + + R
Sbjct: 4857 FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLE 4916
Query: 2958 LLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
L + + L ELL W D E + + + +AL+ + ++
Sbjct: 4917 TALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQ 4976
Query: 3018 PRIERLQQTAALLESRKNPE---SPKVLAQLQAVREAHAE-------LLRRAEARGHGLQ 3067
P ++R+ +T RKN E +P + R++ ++ +L ++EA+ +
Sbjct: 4977 PDVDRVTKT----YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRIN 5032
Query: 3068 ------EQLQLHQLERETLLLDA 3084
+Q+ L LER+ L DA
Sbjct: 5033 QLSARWQQVWLLALERQRKLNDA 5055
Score = 209 bits (533), Expect = 3e-53
Identities = 673/3423 (19%), Positives = 1315/3423 (38%), Gaps = 451/3423 (13%)
Query: 250 HQGQTVQRRLTKILLQLQETELLQ-------TQYEQLVADLLRWIAEKQMQLEARDFPDS 302
HQG+T Q+ L+ + + + LQ T + +V D+ ++ E Q +L R+
Sbjct: 1573 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE---- 1628
Query: 303 LPAMRQLL-AAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
L A+R+ L A + ++ R+ Q+ EA+ LQ + L + L
Sbjct: 1629 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 1688
Query: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
L+W + S Q L L +E L+ K AL + D ++QA P
Sbjct: 1689 ------LDWVTSVGSSG-GQLLTNLPGMEQLSGASLEKGALDTT---DGYMGVNQA---P 1735
Query: 422 ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQEEV 476
L + + + +L Q+ F + A + H+ + ++ E+
Sbjct: 1736 EKL---DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGEL 1792
Query: 477 TVRWQRLLQHLQGQRKQVADMQAVLS-LLQEVEAASHQLEELQEPARSTACGQQLAEVV- 534
++ L + + KQV +Q L LQ+ + LE ++ + G E +
Sbjct: 1793 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLP 1852
Query: 535 ELLQRHDLLEAQVSAHGAHVSHLA---QQTAELDSSLGTSVE------VLQAKARTLAQL 585
LL+R V +H + + Q+ ++++S E +++ K + +
Sbjct: 1853 SLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATER 1912
Query: 586 QQSLVALVRARRALLEQTL-QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
+L + + L L Q +F + + +AW++ C V L ++ G LQ
Sbjct: 1913 YTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQ 1971
Query: 645 KH----KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
+ K L+ E+ HQ L + RD+ PD E
Sbjct: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS---------- 2021
Query: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
+L +F ++ S+ RSSL + + Q Q+ E+ LE +L+
Sbjct: 2022 -----------ILSHF----QSLSYSLAERSSLLQKAIAQSQSVQES-------LESLLQ 2059
Query: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
+ + LE G+ S+ +S + AL+ L+ ++S +M
Sbjct: 2060 SIGEVEQNLE--GKQVSSLSS-GVIQEALAT-NMKLKQDIARQKSSLEA----TREMVTR 2111
Query: 821 AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMA---LFGFCSSCGELQLW 876
D +LQ + +SQ +E L Q + + L++ + +F S G+LQ +
Sbjct: 2112 FMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS--GKLQQF 2169
Query: 877 LE-KQTVLLQRVQPQADT------LEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRY 929
+E K +L QP D ++ + L+ E+ L + L E+SS L
Sbjct: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---- 2225
Query: 930 PGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVE--------VCSFLQECGPTQVQL 981
+ Q Q + + L + + +L+ +E+ + E V +F + T+ +
Sbjct: 2226 --DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2283
Query: 982 RDVLLQLEALQPGSSEDTCHAL--QLAQKKTLVLERRVH--FLQSVVVKVEEP------- 1030
+ A + + +L A K TLV E L+++++++ P
Sbjct: 2284 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
Query: 1031 --------------GYAESQPLQG----------QVETLQGLLKQVQEQVAQRARRQAET 1066
GY + L + E L G+L + QE + R E
Sbjct: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403
Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL 1126
+E+ +L W ES + L+S + + + + + + ++ ++
Sbjct: 2404 H------KEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457
Query: 1127 DAQSQPMAAL--DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ-WLQEGLELQKFGREVD 1183
+ +A L P+SQE N ++ +EL WE+ + + +L++ +
Sbjct: 2458 QKVKEALAGLLVTYPNSQEAENWKKIQ----EELNSRWERATEVTVARQRQLEESASHLA 2513
Query: 1184 GFTATCANHQAWLHLDNLGEDVREALS-----LLQQHREFGRLLSTLGPRAEALRAHGEK 1238
F A + + WL L V LS L Q ++ +L EA R E+
Sbjct: 2514 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF----EARRQQHEQ 2569
Query: 1239 LVQSQHP----------AAHTVREQLQSIQAQWT----RLQGRSEQRRRQLLASLQLQEW 1284
L ++ + V+++LQSI +W +L RS Q + ++ S Q QE
Sbjct: 2570 LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 2629
Query: 1285 KQDVAELMQWMEEKGLMAAH---EPSGARRNILQTLK--------RHEAAESELLATRRH 1333
QD++E ++ + ++ + + +P ++ + +T + HE E++ L
Sbjct: 2630 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 2689
Query: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRS-KWEALNRKMTERGDELQQAGQQEQLLRQ 1392
V +Q ++ L +R E + LQGL + +NR Q ++L
Sbjct: 2690 VLIGEQYLKDELKKR---LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 2746
Query: 1393 LQDAKEQ----------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
L D + Q LE+L+ LQ +E Q +S + ++ + +E +L
Sbjct: 2747 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQ--KSLNQHSGSYEVIVAEGESL------ 2798
Query: 1443 LASMAHGMAASPAI--LEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
L S+ G L E + H L R + +Q+ H+ ++ + W
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW-HVEDL-VPW 2856
Query: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
+ + S T +S + K + EV+ + ++ + S+ L S
Sbjct: 2857 IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916
Query: 1561 HIVEQC----QELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
I ++ Q ++ EL+ + + Q+ FQ+ F ++ E VE + +
Sbjct: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEI 2973
Query: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRV 1668
D +A + + + K +A QE L ++ L Q L ++ Q V
Sbjct: 2974 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3033
Query: 1669 VQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDP 1728
Q+ E + + + +LEG + H +RE + LA G ++G D
Sbjct: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGAIGRDT 3090
Query: 1729 EHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD-LQTAWSEL 1787
+ F +++ + + A +LE + + +R+ + L +L
Sbjct: 3091 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
Query: 1788 WELTQARGHALRDTETTLRVHRDLLEVL------TQVQEKATSLPNNVARDLCGLEAQLR 1841
E +AR L E TL D L T E+A +L V ++ + QL
Sbjct: 3151 TERGKARQEQL---ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
Query: 1842 SHQGLERELVGT-ERQLQELLETA-GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQ 1899
+ ++E V + +LQ++ G +Q ++ + + W L +++ Q
Sbjct: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
Query: 1900 RRAQLERARL-LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELE 1958
R AQL+ A L +F+ A+ SW A D + ++Q+P S K+ Q +L
Sbjct: 3268 RIAQLQEALLHCGKFQDALEPLLSWLA----DTEELIANQKPPSAEYKVVKAQIQEQKLL 3323
Query: 1959 AR---------EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
R + L + ++ Q A LA +++ +L +L+ + ++ A +Q++
Sbjct: 3324 QRLLDDRKATVDMLQAEGGRIAQSAELA---DREKITGQLESLESRWTELLSKAAARQKQ 3380
Query: 2010 LQ-----AEQQEQLFLRECGRLEEILAAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVL 2063
L+ A+Q F + + L+ E L S +G+ +++Q I +H+ + +
Sbjct: 3381 LEDILVLAKQ----FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 2064 T--AQDKKEAA-LRERLKTLRRPR----VRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
A D +A + + L +L P + +++ L R +++ + A+LL
Sbjct: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRK-----AALLD 3491
Query: 2117 ASFTQAATQAEDWIQA--WAQQLKEPVPPGDLRDKLKPLLK-----HQAFEAEVQAHEEV 2169
+ + A ED ++ W ++++ + ++D + +L H A E+ ++
Sbjct: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551
Query: 2170 MTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-E 2224
+ K G+ALL Q+ GE + ++L G++ + D+ + + LE R +
Sbjct: 3552 VDQAIKNGQALLKQT---TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
Query: 2225 FLQRVDLAEAWIQEKEVKMNV-GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
F + W++E E ++ G E Q ++R +E + + + +S
Sbjct: 3609 FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVS 3668
Query: 2284 DLSLQLKNRDPEEV--KIICQRRSQ-------LNNRWASFHGNLLRYQQQLEGA------ 2328
L+L E K++ Q + R + R QQ + A
Sbjct: 3669 RALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 3728
Query: 2329 --------LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL-----E 2375
+ + + E D T ++Q ++A ++D + +S+ L E+ E
Sbjct: 3729 VAETKRKLMALGPIRLEQDQTTAQLQVQKAF--SIDIIRHKDSMDELFSHRSEIFGTCGE 3786
Query: 2376 REVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
+ +Q + ESL ++ + + E L Q V + W + E +
Sbjct: 3787 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW-------ETYEELSPWIE 3839
Query: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLAR 2495
+ + L A L + ++LR Q + E R++ E E K +D
Sbjct: 3840 ETRALIAQLPSPAIDHEQLRQQQE---------EMRQLRESIAEHKPHIDKLL------- 3883
Query: 2496 STGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMER 2555
G QL + + E + ++ ++ L L +A+ ++
Sbjct: 3884 KIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 3943
Query: 2556 WLCSKEDSLASEGLWDPLAPME-----PLLWKHKMLEWDLEVQAGKISALEATAR---GL 2607
+ ++L+S PL P E + +K +LE AL+ G
Sbjct: 3944 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGR 4003
Query: 2608 HQGGHPE--AQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLR 2664
QG + A+ + M+ E + +A R + L+ L + F D + ++
Sbjct: 4004 SQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK 4063
Query: 2665 EKNLVA--LEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQR--EGQRLLQGGHPAS 2720
+ + LE +D +++ Q++ + + E D +H++ E R + G
Sbjct: 4064 DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDG-LHEELEFIRILGADLIFACGETEK 4122
Query: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEA-LRLRRSMEELENWLEPIEVEL-RAP 2778
+++ ++E+ W L ++++ KL+ A +A ++ + +++ + +WL+ ++L P
Sbjct: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182
Query: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG--HCLAQDVEEQARRL 2836
VG L V + L +E + V ++ + E L Q + +++ + E L
Sbjct: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242
Query: 2837 LQRFKSLREPLQERRTALEARSLLLKFFRDADEE-MAWVQEKLPLAAAQDYGQSLSAVRH 2895
+++L E + R+ LE L L F+ A EE M+W+ L AQ V
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
Query: 2896 LQ-EQHQNLESEMSSHEALTRVVLGTGYKLVQ--AGHFAAH---EVAARVQQLEKAMAHL 2949
++ +H L++++ +H+A V G +L++ AG A+ + A Q E +
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 2950 RAEAARRRLLLQQAQ----EAQQFLTELLEAGSWLAERG---------------HVLDSE 2990
+ + LQQAQ E + FL EL S L+ H+
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422
Query: 2991 DMGHSAEATQALLR--RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV 3048
+ E LL RL RD + E Q+ ALLE + + S K+ + +
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKL 4479
Query: 3049 REAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVL 3108
EA L A + LQE + L ++L + + + T SQ +E KV
Sbjct: 4480 EEA----LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ-----IEEHKVF 4530
Query: 3109 EEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKA 3168
+ +A R ++ L Q L+ L+ + I+ +++ WE++ Q
Sbjct: 4531 ANEVNAHRDQIIELDQTG-NQLKFLSQKQD------VVLIKNLLVSVQSRWEKVVQRSIE 4583
Query: 3169 RTENLAAAHE-VHSFQQAAAELQGRMQEKTALMKGE-DGGHSLSSVRTLQQQHRRLEREL 3226
R +L A + F +A +L +++ + + E + + ++ +H+ ++ L
Sbjct: 4584 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 4643
Query: 3227 EAMEK------EVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ 3280
+ R E L + L +V++ W T+ K+ ER L +A
Sbjct: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Query: 3281 -GHAFLGRCQELLAWAQERQ-ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDL 3338
F+ Q L+ W + + +LA + + D+ L+ H+ +E+ + Q L
Sbjct: 4704 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 4763
Query: 3339 RQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ-KLRQRLEQA 3397
++ G++L++NS + V +G+LQEL W C S Q +L Q L+QA
Sbjct: 4764 KRSGRELIENSRDDTTWV-------KGQLQELSTRWD---TVCKLSVSKQSRLEQALKQA 4813
Query: 3398 EAW 3400
E +
Sbjct: 4814 EVF 4816
Score = 162 bits (411), Expect = 4e-39
Identities = 677/3488 (19%), Positives = 1318/3488 (37%), Gaps = 421/3488 (12%)
Query: 272 LQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLA-AFTIFR-TQEKPPR----- 324
L TQ+ + ++D LR + E++ +E + + + +++LL T+ R TQ K
Sbjct: 1398 LTTQHVKYISDALRRLEEEEKVVE-EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKE 1456
Query: 325 --------LQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAE------------LSQ 363
L+Q+ +E L + + +A + + FL G L+E L++
Sbjct: 1457 STDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNK 1516
Query: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRE---SFLKDAEQVL--DQAR 418
+ L A + Q LQ +L +TL ++ E S++ AE+ L Q R
Sbjct: 1517 AYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGR 1576
Query: 419 APPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQ 473
L+ ++ L L+ I + F + + + +E + + +
Sbjct: 1577 TTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKL 1636
Query: 474 EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARS--------TA 525
+ +++ L + + +K++ + AV S LQ+ S +EL E + T+
Sbjct: 1637 HQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 1694
Query: 526 CGQQLAEVVELLQRHDLLEAQVSAHGA-HVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
G +++ L + L GA + + L E+++A+ + L
Sbjct: 1695 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS 1754
Query: 585 LQQSLVALVRARRALLEQ-----TLQRAEFLRNC--EEEEAWLKECGQRVGNAALGRDLS 637
QQ+ + ++ +A L+Q T + + L+ E +E + Q + L
Sbjct: 1755 QQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814
Query: 638 -QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQ 696
++ LQ HK E+ + R + ++ + G P T P +R QG +
Sbjct: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSS-----PETLPSLLKR----QGSFS--- 1862
Query: 697 TRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQA--AAETLLRRHVR 754
V+ L+ + Q D + +E + E + +D+ A E H +
Sbjct: 1863 EDVISHKGDLRFVTISGQKVLDMENS---FKEGKEPSEIGNLVKDKLKDATERYTALHSK 1919
Query: 755 LERV----------LRAFAAELRRLEEQGRAASARASLFTVNSALSPPG---ESLRNPGP 801
R+ F L+ +A A ++ S PG E L
Sbjct: 1920 CTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
Query: 802 WSEASC-HPGPGDAWK------MALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRR 854
E H P + + M + EP PD + +T D + ++SL R
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERS 2037
Query: 855 ARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGL 914
+ L++A+A +Q LE + V+ + +V L ALA L
Sbjct: 2038 SLLQKAIA------QSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091
Query: 915 WAEVS---SSAEQLRQRYP-----GNSTQ---IQRQQEELSQRWGQLEALKREKAVQLAH 963
+++ SS E R+ +ST +Q + E+SQR+ QL ++EK L
Sbjct: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151
Query: 964 SVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE---RRVHFL 1020
+ + Q + ++ A +D H Q Q+ L +E + L
Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211
Query: 1021 QSVVVKVEEPGYA-ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQ 1078
+ +V ++ G+A + Q +V+ L+ ++Q+ V +R + + Q + F + +
Sbjct: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
Query: 1079 LLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL-- 1136
W + + + E S+ ++ + + LL++ +++++ + + L
Sbjct: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331
Query: 1137 --DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQA 1194
PDSQ T +L G + + G K E+ C
Sbjct: 2332 EITAPDSQG--KTGSILPSVGSSVGSV---------NGYHTCKDLTEIQ-----CDMSDV 2375
Query: 1195 WLHLDNLGEDVREALSLLQQ--------HREFGRLLSTLGPRAEALRAHGEKLVQSQHPA 1246
L + LG + E LQ H+E +L L + E L++ S
Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMD---AMSSPTK 2432
Query: 1247 AHTVREQLQSIQAQWTRLQGRSE--QRRRQLLASL--------QLQEWKQDVAELMQWME 1296
TV+ Q +S +A L+ S Q+ ++ LA L + + WK+ EL E
Sbjct: 2433 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2492
Query: 1297 EKGLMAAHEPSGARRNILQTLKRH----EAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
A E + AR+ L+ H +AAES+L E + V
Sbjct: 2493 R-----ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGV------------ 2535
Query: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
L L LN Q Q + +L++ + ++Q EQL A Q T
Sbjct: 2536 ------LGPLSIDPNMLNA----------QKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579
Query: 1413 GQD--LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
G S+ ++QK Q + + L K+ + +S AI++ TQ ELL
Sbjct: 2580 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQI-----DQAIVKSTQYQ----ELL 2630
Query: 1471 QGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKEL 1530
Q +L + LS + P + + L + ++L
Sbjct: 2631 Q--------------DLSEKVRAVGQRLS--VQSAISTQPEAVKQQLEETSEIRSDLEQL 2674
Query: 1531 QVEVKAHQGQVQR--VLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQ 1588
EVK Q VL + L + + + Q LE A+ +A Q
Sbjct: 2675 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734
Query: 1589 QAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRL-INKHQALQEELAIYWSSM 1647
Q FQQ F EL W+++K+ + + L+ + +++ Q+ L + S
Sbjct: 2735 Q---FQQMF---DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
Query: 1648 EELDQTAQTLTGPEVP-EQQRVVQERLREQLRALQELA---ATRDRELEGTL-RLHEFLR 1702
E + ++L P E++R +Q +L E +EL+ A R L+ + + ++
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848
Query: 1703 EAEDLQGWLASQKQAAKGGE-SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAES 1761
EDL W+ K AK E + DP + ++VE + A+
Sbjct: 2849 HVEDLVPWIEDCK--AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906
Query: 1762 LLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK 1821
L+ + +R + + + E QA+ +L + LR + E +++K
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR---EFQESFKNIEKK 2963
Query: 1822 ATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE---------TAGRVQKLCP 1872
+ + L +Q S++ LE+ + ++++ + LE T G V+
Sbjct: 2964 VEGAKHQL-EIFDALGSQACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD 3020
Query: 1873 GPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDL 1931
G A + + + Q + +++R+ +E + + +F VR+ S A + +L
Sbjct: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080
Query: 1932 Q--------VEESSQEPSSGPLKLSAHQWLRAELEARE-KLWQQATQLGQQALLAAGTPT 1982
+ + L L+ L+ ++EA E + + G LL
Sbjct: 3081 DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLG----- 3135
Query: 1983 KEVQEELRALQDQRDQVYQTWARKQERLQAE--QQEQLFLRECGRLEEILAAQEVSLKTS 2040
++ EL AL Q ++ + +QE+L+ + E + + G + AA+E
Sbjct: 3136 --LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193
Query: 2041 ALGSSVEEVEQLIRKHEVF---------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPI 2091
+G+ VE + Q + ++F +K+ + ++ K + +
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253
Query: 2092 LLQRRMRV-KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
+ R + K++A+ A L F A W+ + + PP +
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313
Query: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAG--EVSQRLQGLRKHWEDLRQA 2208
K ++ Q + + + + +AQS A +++ +L+ L W +L
Sbjct: 3314 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3373
Query: 2209 MALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMN----VGDLGQDLEHCLQLRRRLR 2263
A R ++LED +F + + ++ E K+ VG ++ + + L
Sbjct: 3374 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE 3433
Query: 2264 EFRGNSAGDTVGDACI-RSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
E N A D I +S+S L+ P E ++ ++ L R++ R
Sbjct: 3434 EDIENHATDVHQAVKIGQSLSSLT------SPAEQGVLSEKIDSLQARYSEIQDRCCRKA 3487
Query: 2323 QQLEGALEIHVLSRELD----NVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREV 2378
L+ AL L E + N +++K + + D +D+ + R H L E+
Sbjct: 3488 ALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV--LHRQHADHLALNEEI 3545
Query: 2379 HPIQAQVE-SLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ- 2436
+ V+ +++ L Q + E ++ + + + + + K L+ Q
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605
Query: 2437 AQKLQAMLQELLVSAQRLRAQMDTSPA--------PRSPVEARRMLEEHQECKAELDSWT 2488
A K Q+ +EL + + ++ TS P+ + + +E E + LD+
Sbjct: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 3665
Query: 2489 D-SISLARSTGQQLLTAGHPFSSDIRQ----VLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
+ S +L + SD + V + Q + ++ A Q Q Q +QA +
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ-QYEQAADA 3724
Query: 2544 QLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAG-------- 2595
+L W+ + L + G P+ + L+VQ
Sbjct: 3725 EL---------AWVAETKRKLMALG---------PIRLEQDQTTAQLQVQKAFSIDIIRH 3766
Query: 2596 KISALEATA-RGLHQGGHPEAQSAL--GRCQAMLLRKEALFRQAGTRRHRLEELRQL-QA 2651
K S E + R G E Q + + ++++ + EA+ R RLE + L
Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826
Query: 2652 FLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ----ELQR 2707
F + +E++ W+ E AL L A+ QL++QQ +L S+ + + +L +
Sbjct: 3827 FWETYEELSPWIEETR--ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLK 3884
Query: 2708 EGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELEN 2766
G +L + E ++E+ ++ ++ ++++ +++ L +A ++ ++ +++E
Sbjct: 3885 IGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 3944
Query: 2767 WLEPIE---VELRAPTVGQA-LPGVGELLGTQR-------ELEAAVDKKARQAEALLGQA 2815
LE +E LR P + A + + E + + +L+ + + R+ E L+G++
Sbjct: 3945 MLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRS 4004
Query: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA-LEARSLLLKFFRDADEEMAWV 2874
Q ++ A++++++ +++ ++ ++ +ER L+ L KF+ D + +
Sbjct: 4005 QGADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4062
Query: 2875 QEKLPLAA-AQDYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFAA 2932
++ + + G S ++ E + ++ E HE L + + + G
Sbjct: 4063 KDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4122
Query: 2933 HEVAARVQQLEKAMAHLRAEAARRRLLLQQA-QEAQQFLTELLEAGSWLAERGHVLDS-E 2990
EV + ++ A +L R L+ A Q A Q+ L WL L +
Sbjct: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182
Query: 2991 DMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQ--LQAV 3048
+G + L ++ K ++ +E+L L+ + E+ + + + L +
Sbjct: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242
Query: 3049 REAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQ-DYGQDLEGVK 3106
+ L + R H L+ L L Q + L +WLT ++Q D + ++
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
Query: 3107 VLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA---AWERLD 3163
V K + +V + QA V + K L + + RSR+EA WE +
Sbjct: 4303 VELAKHHVLKNDVLA-HQATVETVNKAGNELLESSAG--DDASSLRSRLEAMNQCWESVL 4359
Query: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTA----LMKGEDGGHSLSSVRTLQQQH 3219
Q + R + L + + Q +E++ + E T L + G + R H
Sbjct: 4360 QKTEEREQQLQST--LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
Query: 3220 RRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEA-------WATLQAKAQERG 3272
L +L+A E+ +L + RL L G +K +++ W + +K +ER
Sbjct: 4418 MELYSQLKAKEETYNQLLDKG-RLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
Query: 3273 QWLAQAAQ-GHAFLGRCQELLAW---AQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
L +A F QE + W A++ +AS L + ++ + +H+ E+
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ--IEEHKVFANEV 4534
Query: 3329 RECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
R Q +L Q G QL F+S + L ++ L ++ W QR E +
Sbjct: 4535 NAHRDQIIELDQTGNQL----KFLSQKQDVVL--IKNLLVSVQSRWEKVVQRSIERG--R 4586
Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTE 3448
L ++A+ + W+ L+ + S D EL + D KL ++ ++F QKT
Sbjct: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEF---QKTL 4643
Query: 3449 MEQELLLQPQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTPTMEGSLEFK 3508
+ QP R G +L P Q L L E RD D ++E + +
Sbjct: 4644 GGK----QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
Query: 3509 QHLLPGGR 3516
+ LL G+
Sbjct: 4700 EALLFSGQ 4707
Score = 158 bits (399), Expect = 1e-37
Identities = 338/1660 (20%), Positives = 649/1660 (39%), Gaps = 190/1660 (11%)
Query: 254 TVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAF 313
T+ +++ + + QLQE L +++ + LL W+A+ + +L A P S A +
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPPS--------AEY 3310
Query: 314 TIFRTQEKPPRLQQRGAAEALLFRLQTA--LQAQNRRPFLPHEGLGLAELSQCWAGLE-- 369
+ + Q + +L QR L R T LQA+ R E LA+ + LE
Sbjct: 3311 KVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAE---LADREKITGQLESL 3363
Query: 370 ---WAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
W E A +Q+ QL+ + LA++F A FL E+ L + A
Sbjct: 3364 ESRWTELLSKAAARQK--QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3421
Query: 427 VEAAVQRLGMLEAGI------LPQEGRF-QALAEIADILRQEQYHSWAD-VARRQEEVTV 478
++ + R LE I + Q + Q+L+ + Q D + R E+
Sbjct: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
Query: 479 RWQR----LLQHLQGQRKQVADMQAVLSLLQEVE--AASHQLEELQEPARSTACGQQLAE 532
R R L Q L R D VL+ L EVE +S +++ ++ LA
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
Query: 533 VVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVAL 592
E++ R ++ + A L + G V ++Q K + +
Sbjct: 3542 NEEIVNRKKNVDQAIK----------NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591
Query: 593 VRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV----GNAALGRDLSQIAGALQKHK 647
LEQ Q A +F EE WL+E + + G + G + Q Q+ K
Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ---QRQK 3648
Query: 648 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG--ERAEAVQGGWQLLQTRVVGRGAR 705
L+ EV H+ V +D V P + G + ++L+ + R
Sbjct: 3649 ELKKEVMEHRLV-LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
Query: 706 LQTALLVLQYFADAAEA-ASWLRERRSSLERAS---CGQDQAAAETLLRRHVRLERVLRA 761
+ A+ Q + AA+A +W+ E + L QDQ A+ +V +A
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL---------QVQKA 3758
Query: 762 FAAE-LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
F+ + +R + S R+ +F G E
Sbjct: 3759 FSIDIIRHKDSMDELFSHRSEIF----------------GTCGE---------------- 3786
Query: 821 AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLE 878
+ T+LQ + + L Q YE++ L R ARLE A L F + EL W+E
Sbjct: 3787 -------EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839
Query: 879 KQTVLLQRVQPQA---DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ 935
+ L+ ++ A + L Q + ++A K ++ QL++ P
Sbjct: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
Query: 936 IQRQQEELSQRWGQLEALKREKAVQL----AHSVEVCSFLQECGPTQVQLRDV--LLQLE 989
++ + ++ + Q++ R++A+ L + S ++ F + P L ++ L++
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 990 ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEE-PGYAESQPLQGQVETLQGL 1048
L P + + + T+ LE+ +++ + EE G ++ + +Q
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
Query: 1049 LKQV---QEQVAQRARRQA-----ETQARQSFLQESQQLLLWAESVQAQLRSKE------ 1094
L Q+ E + RA + + + F + LL + Q + E
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
Query: 1095 --VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLG 1152
+ V +A+ + E L EE+ E ++ L A + A + EV ++ +
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEEL----EFIRILGADL--IFACGETEKPEVRKSIDEMN 4133
Query: 1153 QQGQELKVLWEQRQQWLQEGLE--------LQKFGREVDGFTATCANHQAWLHLDNLGED 1204
+ L W++R + L++ ++ LQ +D + +G D
Sbjct: 4134 NAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT------MPPVGTD 4187
Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWT 1262
+ L + +EF + E L GE +++ + +RE L ++ W
Sbjct: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247
Query: 1263 RLQGRSEQRRRQLL-ASLQLQEWKQDVAELMQWM-EEKGLMAAHEP-SGARRNILQTLKR 1319
L + R+ +L A L L +++ + ELM W+ + L+ A P SG + I L +
Sbjct: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307
Query: 1320 HEAAESELLATRRHVEALQQVGRELL-SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
H ++++LA + VE + + G ELL S +++RL+ + WE++ +K ER
Sbjct: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
Query: 1379 ELQQAGQQEQ-LLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQ-----KRHQQLESE 1432
+LQ QQ Q +++D +L ++E L +S+ L + R Q + + QL+++
Sbjct: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Query: 1433 SRTLAAKM--AALASMAHGMAASPAILEETQKHL-RRLELLQGHLAIRGLQLQASVEL-H 1488
T + L ++ + S + E++ L ++ ++ + R +L+ ++ L
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487
Query: 1489 QFCHLSNMELSWVA---EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
+F + ++W+ + + SP S LN S +HK EV AH+ Q+ +
Sbjct: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
Query: 1546 SSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SEL 1603
+G L Q +++ ++ W ++ + R + L A + F + +L
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605
Query: 1604 EGWVEE-KRPLVSSRDYGRDEAATLRLINKHQALQEELA----IYWSSMEELDQTAQTLT 1658
W+E+ + L S + D ++KH+ Q+ L +Y +++ +
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 4665
Query: 1659 GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717
PE ++ +R++ + + R +LE L +F+ + L WL +
Sbjct: 4666 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 4725
Query: 1718 AKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQ 1777
+ + D + ++L FQ ++ + V + L+E V+ +
Sbjct: 4726 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
Query: 1778 QDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
Q+L T W + +L+ ++ L V RD + +L +
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Score = 157 bits (396), Expect = 2e-37
Identities = 402/1996 (20%), Positives = 771/1996 (38%), Gaps = 224/1996 (11%)
Query: 281 ADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPP---RLQQ-RGAAEALLF 336
A+ L+W+ ++++ + Q LA F +F+ ++ P +LQQ G + L+
Sbjct: 3188 AEALQWVVGTEVEI-----------INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3236
Query: 337 RLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRF 396
Q L H+ + E++ W L ++ + QR+ QLQ +F
Sbjct: 3237 SAGKDCDVQG----LEHD---MEEINARWNTL-------NKKVAQRIAQLQEALLHCGKF 3282
Query: 397 QHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQAL-AEIA 455
Q S+L D E+++ + P A V+A +Q +L+ + ++ L AE
Sbjct: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGG 3342
Query: 456 DILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLE 515
I + + + + E + RW LL ++KQ+ D+ + E
Sbjct: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402
Query: 516 ELQEP--ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
+ E A S G Q A++ + + RH LE + H V H A + + SSL + E
Sbjct: 3403 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV-HQAVKIGQSLSSLTSPAE 3461
Query: 574 --VLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNA 630
VL K +L + + ALL+Q L A E E WL E ++ +
Sbjct: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 3521
Query: 631 ALGRDLSQIAGALQK--HKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAV 688
+ +D Q Q H AL E+ + ++ G+ L + GE +
Sbjct: 3522 FV-KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL------LKQTTGEEVLLI 3574
Query: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADAA--------EAASWLRERRSSLERASCGQ 740
Q ++TR AL L+ A E WLRE L A+ G
Sbjct: 3575 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL--ATSGG 3632
Query: 741 DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
E + + + R+ E + R L TVN +L
Sbjct: 3633 QSPTGEQIPQ-------------FQQRQKELKKEVMEHRLVLDTVNEV----SRALLELV 3675
Query: 801 PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
PW K+ A +TI Q D + + + Q A L
Sbjct: 3676 PWRARE------GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
Query: 861 MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS 920
+ G ++L ++ T LQ VQ +A ++++ +++++ + L + +E+
Sbjct: 3730 AETKRKLMALGPIRLEQDQTTAQLQ-VQ-KAFSIDI--IRHKDSMDELFSHR---SEIFG 3782
Query: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHS-VEVCSF---LQECGP 976
+ + ++ T +Q + E L Q++ + L E+ +L + V V F +E P
Sbjct: 3783 TCGEEQK------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
Query: 977 TQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHF--LQSVVVKVEEPGYAE 1034
+ R ++ QL + + ++ Q + + E + H L + +++E E
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
Query: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARR--QAETQARQ--SFLQESQQLLLWAESVQAQL 1090
+ ++ + + + + Q++E+V QRA +A +Q+ Q F + + +L E++ ++L
Sbjct: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
Query: 1091 RSKE-VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM------AALDCPDSQE 1143
R + +V + + +++ E+ Q + L + + + A D ++E
Sbjct: 3957 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKE 4015
Query: 1144 VPNTLRVLGQQGQELKVLWEQRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNL 1201
+ + L + +++K E+R+ + LEL +KF ++ T + Q +H L++
Sbjct: 4016 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4075
Query: 1202 G-------------EDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
G E ++E L + EF R+L A+ + A GE ++ P
Sbjct: 4076 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG-----ADLIFACGE----TEKPE-- 4124
Query: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELM-QWMEEKGL-MAAHEP 1306
VR+ + + W L ++R +L ++Q QD + M W++ + + P
Sbjct: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
Query: 1307 SGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGL 1362
G N ++ L + + E+ + +E L G EL+ ++ + D I+ L L
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242
Query: 1363 RSKWEALNRKMTERGDELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
+ WE L K+ R +L+ A GQ + L +L E+L A Q +G
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA-QRPISGDPKVI 4301
Query: 1419 SQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAI-- 1476
L K H L+++ A + + + + S A + + R + Q ++
Sbjct: 4302 EVELAKHHV-LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360
Query: 1477 ----RGLQLQASVELHQFCH---------LSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
R QLQ++++ Q H L+ ME A G P + E L+
Sbjct: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD----- 4415
Query: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSL------AASGHPQAQHIVEQCQELEGHWAELE 1577
H EL ++KA + ++L GR + + SG Q + LE W +
Sbjct: 4416 --THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL----LEQKWHVVS 4469
Query: 1578 RACEARAQCLQQAVTFQQYFLD-VSELEGWV---EEKRPLVSSRDYGRDEAATLRLINKH 1633
E R L++A+ F + + E W+ E+ + S + L I +H
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEH 4527
Query: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL---REQLRALQELAATRDRE 1690
+ E+ + + ELDQT L + +++ L + + + + + R R
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587
Query: 1691 LEGTLRLHEFLREA-EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
L+ + + EA + L WL + + DP+ +K +FQ + G
Sbjct: 4588 LDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG-GK 4646
Query: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQ----DLQTAWSELWELTQARGHALRDTETTL 1805
Q V + L+ + P Q+ +++ W + + R H L +
Sbjct: 4647 QPVYDTTIRTGRALKE-KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFS 4705
Query: 1806 RVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE 1862
D L+ L E + V DL + + +H+ ++EL G ++L+
Sbjct: 4706 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKEL-GKRTGTVQVLK 4764
Query: 1863 TAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDYA 1921
+GR V+ + Q ++ W + + ++++LE+A A FR V
Sbjct: 4765 RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLL 4824
Query: 1922 SWAARVRQDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
W + Q L+ + + + L H+ ++E + A +G+ L
Sbjct: 4825 EWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 4884
Query: 1981 PTKEVQEELRALQDQRDQVYQTWARK-QERLQAEQQEQLFLRECGRLEEILAAQEVSLKT 2039
+ + R + TWA++ Q+RL+ E + E LEE+LA + + T
Sbjct: 4885 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL--LEELLAWIQWAETT 4942
Query: 2040 ------SALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRD-RLPIL 2092
+ +++ V+ LI +H+ F++ +T +K+ + KT +R + P +
Sbjct: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMT---RKQPDVDRVTKTYKRKNIEPTHAPFI 4999
Query: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQAWAQQLKEPVPPGDLR 2147
+ R ++ S + + S ++A + W Q W L+ D
Sbjct: 5000 EKSRSGGRK---SLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056
Query: 2148 DKLKPLLKHQAFEAEV 2163
D+L+ L + F+ +V
Sbjct: 5057 DRLEELKEFANFDFDV 5072
Score = 144 bits (363), Expect = 2e-33
Identities = 378/1897 (19%), Positives = 746/1897 (39%), Gaps = 238/1897 (12%)
Query: 826 DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLL 884
D D + + ++ + +L R A+L+EA+ G F + L WL L+
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
Query: 885 QRVQPQADTLEVM--QLKYENFLTAL-----AVGKGLWAE---VSSSAEQLRQRYPGNST 934
+P + +V+ Q++ + L L A L AE ++ SAE +
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL------ADRE 3354
Query: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCS-FLQECGPTQVQLRDVLLQLEALQP 993
+I Q E L RW +L + + QL + + F + P L +L +P
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414
Query: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQ-SVVVKVEEP-----GYAESQPLQGQVETLQG 1047
++ Q+ + K L + H VK+ + AE L ++++LQ
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474
Query: 1048 LLKQVQEQVAQRARR--QAETQARQSFLQESQQLLLWAESVQAQL--------------- 1090
++Q++ ++A QA + AR F ++ ++L W V+ +L
Sbjct: 3475 RYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
Query: 1091 --------------RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
R K V + + Q LL+ Q EE+ L QE+L + + +
Sbjct: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLK--QTTGEEVLLIQEKLDGIKTRYADITVT 3591
Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH---- 1192
S + TL Q + + +E+ WL REV+ AT
Sbjct: 3592 ----SSKALRTLEQARQLATKFQSTYEELTGWL----------REVEEELATSGGQSPTG 3637
Query: 1193 ----QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP-RAEALRAHGEKLVQSQHPAA 1247
Q L ++V E +L E R L L P RA R +KLV +
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA---REGLDKLVSDANEQY 3694
Query: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL-QEWKQDVAELMQWMEE-KGLMAAHE 1305
V + + QR ++ A++Q Q+++Q + W+ E K + A
Sbjct: 3695 KLVSDTIG--------------QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 3740
Query: 1306 PSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRP-----CGQED---IQT 1357
P ++ QT + + ++ + RH +++ EL S R CG+E +Q
Sbjct: 3741 PIRLEQD--QTTAQLQVQKAFSIDIIRHKDSMD----ELFSHRSEIFGTCGEEQKTVLQE 3794
Query: 1358 RLQGLRSKWEALNRKMTERGDELQQAG--------QQEQLLRQLQDAKEQLEQLEGALQS 1409
+ + L ++EA++ +ER L++A E+L +++ + + QL
Sbjct: 3795 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAID 3854
Query: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRL 1467
E LR Q ++ ++ +E + K+ + + + E+ QK
Sbjct: 3855 HE---QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMY 3911
Query: 1468 ELLQGHLAIRGLQLQASV-------ELHQFCH--LSNMELSWVAEHMPHGSPTSYT---E 1515
++ + R L L +V E H L +E MP P E
Sbjct: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
C++ +S + ++LQ +A + + + ++ GRS A A+ I ++ ++ W +
Sbjct: 3972 CISDNKSATVELEKLQPSFEALKRRGEELI--GRSQGADKDLAAKEIQDKLDQMVFFWED 4029
Query: 1576 LE-RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY-GRDEAATLRLINKH 1633
++ RA E + L ++++ D++ L +++ + +V + G D + + +
Sbjct: 4030 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA 4089
Query: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
+ ++EE +E + L ++ V++ + E A + L T LE
Sbjct: 4090 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE- 4148
Query: 1694 TLRLHEFLREAEDLQG-------WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
+L + ++ A Q WL + +G D + +F+ +V
Sbjct: 4149 --KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206
Query: 1747 MGSQRVAACRLLAESLLERG--HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
+ E +L++ + ++R+ +L+ W L E R H L
Sbjct: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Query: 1805 LRVHRDLLEVLTQV---QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
L + LE L E+ ++ D +E +L H L+ +++ + ++ +
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDY 1920
+ + + G A +++ R +A+ Q W + ++ E+R QL+ A+ F + + D+
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
Query: 1921 ASWAARVRQDLQVEE-SSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-- 1977
R+ L + + P + +L H L ++L+A+E+ + Q G+ LL+
Sbjct: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
Query: 1978 -AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQL-----FLRECGRLEEILA 2031
+G+ +K E+ AL +Q+ V + K E +++ +E L F L
Sbjct: 4447 DSGSGSK--TEQSVALLEQKWHVVSS---KMEERKSKLEEALNLATEFQNSLQEFINWLT 4501
Query: 2032 AQEVSLKTSALGSSV-EEVEQLIRKHEVFLKVLTAQDKKEAALRE---RLKTLRRPR--- 2084
E SL ++ S + V I +H+VF + A + L + +LK L + +
Sbjct: 4502 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 4561
Query: 2085 -VRDRLPILLQRRMRVKELAESRGHALHASLLMA-SFTQAATQAEDWIQAWAQQLKEPVP 2142
+++ L + R +V + + RG +L + A F +A + DW++ L +
Sbjct: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
Query: 2143 PGDLRDKLK-PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG---- 2197
+ DK+K L KH+ F+ + + V + + G AL + E SQ+L
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--KEKTLLPEDSQKLDNFLGE 4679
Query: 2198 LRKHWEDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMNVGD-LGQDLEHC 2255
+R W+ + R +LE+ F +F+ + W+ + E ++ + DL+
Sbjct: 4680 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 4739
Query: 2256 LQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFH 2315
+ L + F+ G G + S L +RD + + + +L+ RW +
Sbjct: 4740 MNLMDAHKVFQ-KELGKRTGTVQVLKRSGRELIENSRD--DTTWVKGQLQELSTRWDTVC 4796
Query: 2316 GNLLRYQQQLEGALE--------IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
+ Q +LE AL+ +H+L L + ++ + AL D E++Q L
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL------PDDTEALQSL 4850
Query: 2368 LRKHEELEREVHPIQAQVES---LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRA 2424
+ H+E ++V + V S + + +C P+ ++H + + ++ + A
Sbjct: 4851 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCH--PDCITTIKHWITIIRARFEEVLTWA 4908
Query: 2425 QKRREALD-ALHQAQKLQAMLQELLV---SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
++ ++ L+ AL + +L+ELL A+ Q D P P++ + ++ EHQ
Sbjct: 4909 KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 4968
Query: 2481 KAEL-------DSWTDS-------------ISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
E+ D T + I +RS G++ L+ P I
Sbjct: 4969 MEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5028
Query: 2521 QELSSLEGAWQE-HQLQLQQALELQLFLSSVEKMERW 2556
++ L WQ+ L L++ +L L +E+++ +
Sbjct: 5029 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEF 5065
Score = 79.7 bits (195), Expect = 5e-14
Identities = 264/1272 (20%), Positives = 486/1272 (38%), Gaps = 175/1272 (13%)
Query: 247 SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
S + Q + + ++ +L+ ++L Q+ + +L WI E + + P
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDH 3855
Query: 307 RQLLAAFTIFRTQEKPPRLQQRGAAEAL-----LFRLQTALQAQNRRPFLPHEGLGLAEL 361
QL R Q++ R + AE L ++ L+ N P EG + E
Sbjct: 3856 EQL-------RQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN-----PEEGEMVEEK 3903
Query: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Q E A + ++QR L L + + + E L+ E + + R PP
Sbjct: 3904 YQ---KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960
Query: 422 A---------------SLATVEA--------AVQRLGMLEAGILPQEGRFQALAEIADIL 458
ATVE A++R G G + A EI D L
Sbjct: 3961 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4020
Query: 459 RQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQ 518
Q + W D+ R EE +++ L L+ K DM A+L+ +++ + H LE
Sbjct: 4021 DQMVFF-WEDIKARAEEREIKF---LDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-- 4074
Query: 519 EPARSTACGQQLAEVVELLQR-----HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
P + +Q E E ++ H+ LE + GA + +T + +
Sbjct: 4075 -PGIDPSIIKQQVEAAETIKEETDGLHEELEF-IRILGADLIFACGETEKPE-------- 4124
Query: 574 VLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRVGNAA- 631
++ + ++L + R LE +Q A ++ + WL ++
Sbjct: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
Query: 632 LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG---ERAEAV 688
+G DL+ + L + K + EV++ Q L +G +L ++ + D E +
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242
Query: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADA-AEAASWLRERRSSL--ERASCGQDQAAA 745
+ W+ L ++ R +L+ ALL L F A E SWL L +R G +
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
Query: 746 ETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEA 805
L + HV VL + +A++ TVN A + ES S
Sbjct: 4303 VELAKHHVLKNDVL-----------------AHQATVETVNKAGNELLESSAGDDASSLR 4345
Query: 806 SCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG 865
S W+ ++LQ + Q +S AQ + +E+ F
Sbjct: 4346 SRLEAMNQCWE--------------SVLQKTEEREQQLQSTLQQAQGFHSEIED----FL 4387
Query: 866 FCSSCGELQLWLEKQT-VLLQRVQPQADT----LEVMQLKYENFLTALAVGKGLWAEVSS 920
+ E QL K T L + + Q DT ++ K E + L G+ +
Sbjct: 4388 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD 4447
Query: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
S G+ ++ ++ L Q+W + + E+ +L ++ + + Q +
Sbjct: 4448 S---------GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 4498
Query: 981 LRDVLLQ-LEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ 1039
+ Q L P S Q+ + K E H + ++++++ G Q
Sbjct: 4499 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH--RDQIIELDQTGNQLKFLSQ 4556
Query: 1040 GQ-VETLQGLLKQVQ---EQVAQRA--RRQAETQAR---QSFLQESQQLLLWAESVQAQL 1090
Q V ++ LL VQ E+V QR+ R ++ AR + F + ++L+ W E ++ L
Sbjct: 4557 KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL 4616
Query: 1091 RSK-EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM--AALDCPDSQEVPNT 1147
S+ E+S D + L +H++ + + Q + + L DSQ++ N
Sbjct: 4617 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 4676
Query: 1148 LRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL--DNLGE-- 1203
L + + + +RQ L+E L G+ +D A WL+ L E
Sbjct: 4677 LGEVRDKWDTVCGKSVERQHKLEEALLFS--GQFMDALQALV----DWLYKVEPQLAEDQ 4730
Query: 1204 ----DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
D+ ++L+ H+ F + L + L+ G +L+++ V+ QLQ +
Sbjct: 4731 PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELST 4790
Query: 1260 QWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNI 1313
+W + S ++ +L +L Q + ++ V L++W+ E + A + + A +++
Sbjct: 4791 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSL 4850
Query: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
+ T H+ ++ R V + +G +L+ C + I T W + R
Sbjct: 4851 IDT---HKEFMKKVEEKRVDVNSAVAMGEVILA--VCHPDCITT-----IKHWITIIRAR 4900
Query: 1374 TERGDELQQAGQQ--EQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK---RHQQ 1428
E + QQ E L +L E LE+L +Q +ET R + + + R +
Sbjct: 4901 FEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKA 4960
Query: 1429 LESESRTLAAKM 1440
L +E +T +M
Sbjct: 4961 LIAEHQTFMEEM 4972
Score = 51.2 bits (121), Expect = 2e-05
Identities = 301/1593 (18%), Positives = 560/1593 (35%), Gaps = 312/1593 (19%)
Query: 1947 LSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARK 2006
L + LR +E E L Q A ++ AL EE L Q
Sbjct: 413 LEREKSLRPAVERLELLLQIANKIQNGALNC---------EEKLTLAKNTLQADAAHLES 463
Query: 2007 QERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQ 2066
+ +Q E ++++EC E ++ +V L+ + E + E+ +V+ Q
Sbjct: 464 GQPVQCESDVIMYIQEC---EGLIRQLQVDLQ-------ILRDENYYQLEELAFRVMRLQ 513
Query: 2067 DKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKEL-AESRGHALHASLLMASFTQAATQ 2125
D+ LR L R L ++ + L AE A H+S + F + T+
Sbjct: 514 DEL-VTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSST-SWFRKPMTR 571
Query: 2126 AE--------------------DWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
AE W++ +L+ DL + E +++
Sbjct: 572 AELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL----------PSVELQLET 621
Query: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQR--------LQGLRKHWEDLRQAMALRGQELE 2217
+ + TSV + G ++ ++ G++SQ L L + L++ + R + L+
Sbjct: 622 QQHIHTSVEELGSSV-KEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ 680
Query: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277
+F+ R W+ EKE + D + + R E
Sbjct: 681 SLH---KFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK---QD 734
Query: 2278 CIRSISDLS--LQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVL- 2334
RS+ D + L L+N + Q +++ + L++ +QL +E HV
Sbjct: 735 VFRSLQDTAELLSLENHPAK----------QTVEAYSAAVQSQLQWMKQLCLCVEQHVKE 784
Query: 2335 ----------SRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ 2384
+REL++ + +Q+ + D L ++ LL+ + + ++ ++
Sbjct: 785 NTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSS 844
Query: 2385 VESL---EREVGRLCQRSPEAAHGLR----------HRQQEVA---ESWWQLRSRAQKRR 2428
V SL + + +L RSP+ H L+ +RQ E+ L +Q+ +
Sbjct: 845 VASLVGRSKTIVQLKPRSPD--HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
Query: 2429 ---------EAL-------------DALHQA-------QKLQAMLQEL------LVSAQR 2453
EA+ DA+ A QK+ A+ +L L+S
Sbjct: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
Query: 2454 LRAQMDT----------SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT 2503
LR +D S AP + + L+ H E L DS+ + + +L
Sbjct: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL-- 1018
Query: 2504 AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDS 2563
++ A + + S+E +E + EL+ +E+ E+ + + S
Sbjct: 1019 -----EEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQS 1073
Query: 2564 LASE----GLWDP----LAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEA 2615
LAS W +A E + L DL+ + K + LHQ P +
Sbjct: 1074 LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF------LHQS--PSS 1125
Query: 2616 QSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLR--EKNLVALEE 2673
S + L E + G L +L+ + ++ Q+ ++ E L E
Sbjct: 1126 SSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185
Query: 2674 GLLDTAMLPAQLQKQQNFQAE----------LDASMHQQQELQREGQRLLQGGHPASEAI 2723
L D + L A +++ ++ LD + + + + + RL + E
Sbjct: 1186 VLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245
Query: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME-ELENWLEPIEVELRAPTVGQ 2782
QE+ +L W + + + ++L+ E L R+ L W+E + GQ
Sbjct: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305
Query: 2783 ALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKS 2842
A +L Q + A+ + + + L Q Q F ++ + +D E Q +S
Sbjct: 1306 AEDS--RVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
Query: 2843 LREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQN 2902
++ +RR L + + + F D L Q A+R L+E+ +
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYT----ALVTLTTQHVKYISDALRRLEEEEKV 1419
Query: 2903 LESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ-QLEKAMAHLRAEAARRRLLLQ 2961
+E E H + +LG L + A + +EKA+ L + L +
Sbjct: 1420 VEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI--LEQQVLSEELTTK 1477
Query: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
+ Q ++ T + +LA+ GH L +
Sbjct: 1478 KEQVSEAIKTSQI----FLAKHGHKLSEK------------------------------- 1502
Query: 3022 RLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLL 3081
E ++ QL A+ +A+ +L + + LQ QL HQ E++TL
Sbjct: 1503 ---------------EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA-HQTEQKTL- 1545
Query: 3082 LDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGA 3141
+ Q LE + +GQA+ R LAG R
Sbjct: 1546 ----------QKQQNTCHQQLEDL-------------CSWVGQAE----RALAGHQGRTT 1578
Query: 3142 PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMK 3201
+ +Q +S ++ + + + SF +++G M+E +
Sbjct: 1579 QQDLSALQKNQSDLKDLQDDIQ-------------NRATSFATVVKDIEGFMEENQTKLS 1625
Query: 3202 GEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KV 3257
+ + ++Q+ L+ E +KE+ T A + A LA K+
Sbjct: 1626 PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKI 1685
Query: 3258 QEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQL 3317
+ + GQ L L ++L + E+ L +++ E+L
Sbjct: 1686 DALLDWVTSVGSSGGQLLTN-------LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 1738
Query: 3318 LGQHEELGQEIRECRLQAQDL---RQEGQQLVD-NSHFMSAEVTECLQELEGRLQE---- 3369
Q E + +E Q Q+ Q Q +D + H ++ E + LQ+ G L+E
Sbjct: 1739 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 1798
Query: 3370 -LEEAWALRWQRCAESWGLQKLRQRLEQAEAWL 3401
L ++ A Q LQK Q ++ E+WL
Sbjct: 1799 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831
Score = 42.4 bits (98), Expect = 0.009
Identities = 94/454 (20%), Positives = 171/454 (37%), Gaps = 70/454 (15%)
Query: 3023 LQQTAALLESRKNPESPKVLAQL--QAVREAHAELLRRAEARGHGLQEQLQLHQLERETL 3080
++Q L+ + P++P L L Q + E+L + +G ++E
Sbjct: 330 IKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG----------RIEELYK 379
Query: 3081 LLDAWLTTKAATAESQDYGQDLE---GVKVLE--EKFDAFRKEVQSLGQAKVYALRKLAG 3135
LL+ W+ + D+E G ++E E+ + R V+ L L ++A
Sbjct: 380 LLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE-----LLLQIAN 434
Query: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
++ GA + ++ ++A L+ + E+ +V + Q L ++Q
Sbjct: 435 KIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCES-----DVIMYIQECEGLIRQLQV 489
Query: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA 3255
+++ E+ + L + RL+ EL + E L + L P L
Sbjct: 490 DLQILRDEN----YYQLEELAFRVMRLQDELVTLRLECTNLYRKG-HFTSLELVPPSTLT 544
Query: 3256 KVQ-EAWATLQAKAQERGQWLAQ-----------AAQGHAFLGRCQELLAWAQERQELAS 3303
+A +A W + +++ L ELL+W +E Q
Sbjct: 545 TTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604
Query: 3304 SEELAEDVAGAEQLL--GQH-----EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEV 3356
E D+ E L QH EELG ++E RL + Q N H AE
Sbjct: 605 RAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ-------NFHTSYAET 657
Query: 3357 TECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEA---WLACWEGLLLKPDY 3413
L +LE + +L+E + R + LQ L + + +A A WL E L D+
Sbjct: 658 ---LGKLETQYCKLKETSSFRMRH------LQSLHKFVSRATAELIWLNEKEEEELAYDW 708
Query: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
+ S++ + +L L +++ F +Q T
Sbjct: 709 SDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742
Score = 37.7 bits (86), Expect = 0.21
Identities = 46/261 (17%), Positives = 103/261 (39%), Gaps = 7/261 (2%)
Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQ-L 3246
EL ++E ++ + G+ L SV + + + +E + V + ++ Q
Sbjct: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNF 650
Query: 3247 HPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEE 3306
H + L K++ + L+ + R + L H F+ R L W E++E + +
Sbjct: 651 HTSYAETLGKLETQYCKLKETSSFRMRHLQSL---HKFVSRATAELIWLNEKEEEELAYD 707
Query: 3307 LAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGR 3366
+++ + EL E+ E + + L+ + L +H V ++ +
Sbjct: 708 WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767
Query: 3367 LQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP---DYGHSVSDVELL 3423
LQ +++ Q E+ + + E++L + + + D+ S+S +E L
Sbjct: 768 LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827
Query: 3424 LHRHQDLEKLLAAQEEKFAQM 3444
L D ++ L + A +
Sbjct: 828 LQDSMDEKEQLIQSKSSVASL 848
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 345 bits (885), Expect = 5e-94
Identities = 209/564 (37%), Positives = 312/564 (55%), Gaps = 27/564 (4%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + +G+ L+ LLE+ISGE LP P +G++R H
Sbjct: 45 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFH 102
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 103 KIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEET---- 158
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVN+ +F SW DGL ALIH HRPDL+DY LR D
Sbjct: 159 -----SAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKD 213
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
P+ NL AF VAE+ L I ++LD ED+ +PDE++IMTYVS +YH + Q +T
Sbjct: 214 DPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAA 273
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L +YE+L ++LL WI LE R S+ AM++ L F +
Sbjct: 274 NRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDY 333
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R KPPR+Q++ E LQT L+ +R F+P EG +++++ W GLE E
Sbjct: 334 RRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYE 393
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
L + +LQRL+ LA +F+ KA+L E++ + E++L Q A L V A ++R
Sbjct: 394 DWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEA 453
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E+ + + R + +A +A L + YH A V R + + +W L Q +R +
Sbjct: 454 FESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER 513
Query: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR----HDLLEAQ--VSAH 550
M+ +L + ++ +L+ R+ L VE LQ H + E Q ++AH
Sbjct: 514 MEKLLETIDQL--------QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565
Query: 551 GAHVSHLAQQTAELDSSLGTSVEV 574
+ L + E + +G E+
Sbjct: 566 DQFKATLPEADRERGAIMGIQGEI 589
Score = 61.2 bits (147), Expect = 2e-08
Identities = 96/408 (23%), Positives = 166/408 (40%), Gaps = 36/408 (8%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852
Q + + ++ Q + L AF+ L D+ R L Q K + L E R
Sbjct: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
Query: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
+ L KF + A AW + K + + +DY + L VR L +H+ ES++++H+
Sbjct: 403 LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + + A V +R Q + +L +RR L++ ++ + +
Sbjct: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
Query: 2972 EL--------LEAGSWLAERGHVLDSED--MGHSAEATQALLRRLEATKRDL-EAFSPR- 3019
+L +WL G V D +D + HS E TQ+LL + K L EA R
Sbjct: 523 QLQLEFARRAAPFNNWL--DGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
Query: 3020 --------IERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL- 3070
I+++ QT L R +P + Q + + + +R LQE+L
Sbjct: 581 AIMGIQGEIQKICQTYGL---RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Query: 3071 --QLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVK-VLEEKFDAFRKEVQSLGQAKV 3127
Q+++ R A A+ ++ G+ G+ LEE+ R++ Q++ K
Sbjct: 638 RQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697
Query: 3128 YALRKLAG---TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+ +L G L+ H I WE+L +I ART N
Sbjct: 698 -NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI-ARTIN 743
Score = 57.8 bits (138), Expect = 2e-07
Identities = 91/382 (23%), Positives = 149/382 (39%), Gaps = 49/382 (12%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI GLEQ E W +++
Sbjct: 344 EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED-WLLSEIRR 402
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP-MEPLLWKHKMLEWDLEVQA 2594
Q L+ + F E W KE+ L+ L + LL +H+ E DL
Sbjct: 403 LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQ 2654
++ + A A+ L++ + EA S RCQA+ + + L RR LE +
Sbjct: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM-------- 514
Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL-----QREG 2709
EK L +++ L+ A ++ F LD ++ Q++ E
Sbjct: 515 ----------EKLLETIDQLQLEFA------RRAAPFNNWLDGAVEDLQDVWLVHSVEET 558
Query: 2710 QRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLE 2769
Q LL + E E GA+ G +Q ++QK C+ LR L
Sbjct: 559 QSLLTAHDQFKATLPEADRERGAIMG-IQ-------GEIQKICQTYGLRPCSTNPYITLS 610
Query: 2770 PIEVELRAPTVGQALPG----VGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE---- 2821
P ++ + V + +P + E L Q+ E + A QA A+ QA V E
Sbjct: 611 PQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRL 670
Query: 2822 GHCLAQDVEEQARRLLQRFKSL 2843
LA +EEQ L Q+ +++
Sbjct: 671 AAGLAGSLEEQMAGLRQQEQNI 692
Score = 53.1 bits (126), Expect = 5e-06
Identities = 60/252 (23%), Positives = 106/252 (42%), Gaps = 36/252 (14%)
Query: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
E L+ + W++ + + ++ + + LE R++R + + C I+
Sbjct: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLED-------FRDYRRLHKPPRIQEKCQLEIN 351
Query: 2284 DLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
+LQ K R P E K++ S + N W Y+ L EI L R
Sbjct: 352 FNTLQTKLRLSHRPAFMPSEGKLV----SDIANAWRGLEQVEKGYEDWLLS--EIRRLQR 405
Query: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384
L ++ ++ ++K +L +A GK+ L+ V+ LLR+HE E ++ Q +
Sbjct: 406 -LQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
Query: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML 2444
VE + L + A + R Q + + W L + QKRR DAL + +KL +
Sbjct: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRR---DALERMEKLLETI 521
Query: 2445 QELLVSAQRLRA 2456
+L + R A
Sbjct: 522 DQLQLEFARRAA 533
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/118 (25%), Positives = 55/118 (46%), Gaps = 1/118 (0%)
Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
L F Q A+ E W + + L + L +++ LL+ H+AFE+++ AH++ + +
Sbjct: 409 LAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDL 2231
A + L + A V+ R Q + W++L R LE LE + ++ L
Sbjct: 469 AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQL 526
Score = 48.1 bits (113), Expect = 2e-04
Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 45/264 (17%)
Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWLH-----LDNLGED---VREALSLLQQHR 1216
+ WL E LQ+ + F + H+AW L D ++E +LL++H
Sbjct: 393 EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHE 452
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL- 1275
F L+ R E + A ++L + + A +V + Q+I QW L +++RR L
Sbjct: 453 AFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE 512
Query: 1276 --------LASLQLQ---------EWKQDVAELMQ--WM-----EEKGLMAAHEPSGARR 1311
+ LQL+ W E +Q W+ E + L+ AH+ A
Sbjct: 513 RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA-- 570
Query: 1312 NILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED-IQTRLQGLRSKWEALN 1370
TL + ++ + ++ + Q RPC I Q + +KW+ +
Sbjct: 571 ----TLPEADRERGAIMGIQGEIQKICQT----YGLRPCSTNPYITLSPQDINTKWDMVR 622
Query: 1371 RKMTERGDELQQAGQQEQLLRQLQ 1394
+ + R LQ+ ++Q+ +L+
Sbjct: 623 KLVPSRDQTLQEELARQQVNERLR 646
Score = 47.4 bits (111), Expect = 3e-04
Identities = 78/362 (21%), Positives = 141/362 (38%), Gaps = 59/362 (16%)
Query: 442 LPQEGRFQALAEIADILR-----QEQYHSW--ADVARRQEEVTVRWQRLLQHLQGQRKQV 494
+P EG+ +++IA+ R ++ Y W +++ R Q LQHL + +Q
Sbjct: 368 MPSEGKL--VSDIANAWRGLEQVEKGYEDWLLSEIRRLQR---------LQHLAEKFRQK 416
Query: 495 ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHV 554
A + + +E E L + +A L EV LL+RH+ E+ ++AH V
Sbjct: 417 ASLHEAWTRGKE--------EMLSQRDYDSAL---LQEVRALLRRHEAFESDLAAHQDRV 465
Query: 555 SH---LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQ------ 605
H LAQ+ ELD SV ++ + + +L L + RR LE+ +
Sbjct: 466 EHIAALAQELNELDYHEAASV---NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
Query: 606 --RAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKH---KALEAEVHRHQAVC 660
+ EF R WL + + + L + + L H KA E R +
Sbjct: 523 QLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582
Query: 661 V----DLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL------ 710
+ ++ + + R T P + + W +++ V R LQ L
Sbjct: 583 MGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVN 642
Query: 711 --LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRR 768
L Q+ A A W++ + + R + G + E + + + ++ + + R
Sbjct: 643 ERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIIN-YKTNIDR 701
Query: 769 LE 770
LE
Sbjct: 702 LE 703
Score = 45.8 bits (107), Expect = 8e-04
Identities = 70/338 (20%), Positives = 128/338 (37%), Gaps = 25/338 (7%)
Query: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
G Q+R L ++ L+ + LQ ++ + A W+ L+ S+ +
Sbjct: 501 GTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQS 560
Query: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFL--PHEGLGLAELSQCWA 366
LL A F+ P ++RGA + +Q Q RP P+ L +++ W
Sbjct: 561 LLTAHDQFKAT-LPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWD 619
Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
+ +R Q LQ+ L + Q E L R+F +A +++ +V + R +
Sbjct: 620 MVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ--AKVEEVGRLAAGLAGS 677
Query: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQH 486
+E + L E I+ + L +L++ E + V W++LL
Sbjct: 678 LEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTS 737
Query: 487 LQGQRKQVADMQAVLSL-------LQEVEAASHQLEE----LQEPARSTAC----GQQLA 531
+ +V + L E A+ + + + EP AC G L
Sbjct: 738 IARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLG 797
Query: 532 EV--VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSS 567
EV ++ D A V A + + ++TAE D++
Sbjct: 798 EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTT 835
Score = 43.5 bits (101), Expect = 0.004
Identities = 92/480 (19%), Positives = 181/480 (37%), Gaps = 89/480 (18%)
Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEK---------RPLVSSRDYGRDEAATLR 1628
R C+ A + ++Y SEL W+ P +S+ ++ R
Sbjct: 275 RICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYR 334
Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678
++K +QE +L I ++++ QT L+ +P + ++V + L + +
Sbjct: 335 RLHKPPRIQEKCQLEINFNTL----QTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEK 390
Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
++ + R L+ L E R+ L + W +++ + + L +
Sbjct: 391 GYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRR 450
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
F+ + RV LA+ L E + V R Q + W L LTQ R A
Sbjct: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
Query: 1798 LRDTETTLRVHRDLLEVLTQVQ----EKATSLPN---NVARDLCGL---------EAQLR 1841
L E LLE + Q+Q +A N DL + ++ L
Sbjct: 511 LERME-------KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLT 563
Query: 1842 SHQGLERELVGTERQLQELLETAGRVQKLC------PGPQAHAVQQRQQAVTQAWAVLQR 1895
+H + L +R+ ++ G +QK+C P + Q + W ++++
Sbjct: 564 AHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK 623
Query: 1896 RMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRA 1955
+ R L+ LAR +V + L+ + ++Q + GP W++A
Sbjct: 624 LVPSRDQTLQEE--LAR------------QQVNERLRRQFAAQANAIGP-------WIQA 662
Query: 1956 ELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
++E ++G+ A AG+ ++E++ L+ Q + + +RL+ + Q
Sbjct: 663 KVE----------EVGRLAAGLAGS----LEEQMAGLRQQEQNII-NYKTNIDRLEGDHQ 707
Score = 43.1 bits (100), Expect = 0.005
Identities = 83/429 (19%), Positives = 157/429 (36%), Gaps = 49/429 (11%)
Query: 2855 EARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALT 2914
E L+ ++ + A E + W++ +P + S+SA++ E ++
Sbjct: 285 ENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQE 344
Query: 2915 RVVLGTGYKLVQAGHFAAHEVAAR----------------VQQLEKAMAHLRAEAARRRL 2958
+ L + +Q +H A ++Q+EK RR
Sbjct: 345 KCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQ 404
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EATQALLRRLEATKRDLEAFS 3017
LQ E + L EA W + +L D + + +ALLRR EA + DL A
Sbjct: 405 RLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
Query: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQ---------E 3068
R+E + A L E+ V ++ QA+ + L + R L+ +
Sbjct: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK-- 3126
QLQL + R + WL + +E + L D F+ + + +
Sbjct: 523 QLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
Query: 3127 ----VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL---AAAHEV 3179
++K+ T P+I I W+ + + + +R + L A +V
Sbjct: 582 IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641
Query: 3180 HS--FQQAAAE-------LQGRMQEKTALMKGEDGG--HSLSSVRTLQQQHRRLERELEA 3228
+ +Q AA+ +Q +++E L G G ++ +R +Q + ++
Sbjct: 642 NERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR 701
Query: 3229 MEKEVARLQ 3237
+E + LQ
Sbjct: 702 LEGDHQLLQ 710
Score = 39.3 bits (90), Expect = 0.072
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 36/199 (18%)
Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
+D R +RL K + QLE TL K M + + +A + LE+
Sbjct: 328 EDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQ 387
Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
+K +RRL+ LQ HLA +F +++ +W S
Sbjct: 388 VEKGYEDWLLSEIRRLQRLQ-HLA------------EKFRQKASLHEAWTRGKEEMLSQR 434
Query: 1512 SYTECL-NGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Y L ++L R+H+ + ++ AHQ +V+ + + + L + +A + +CQ +
Sbjct: 435 DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494
Query: 1571 GHWAELERACEARAQCLQQ 1589
W L + R L++
Sbjct: 495 DQWDNLGTLTQKRRDALER 513
Score = 39.3 bits (90), Expect = 0.072
Identities = 64/278 (23%), Positives = 112/278 (40%), Gaps = 32/278 (11%)
Query: 1994 DQRDQVYQTWARKQ-ERLQAEQQEQLFLRECGRLEEILAA--QEVSLKTSALGSSVEEVE 2050
+Q ++ Y+ W + RLQ Q R+ L E +E+ + + ++EV
Sbjct: 386 EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
Query: 2051 QLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKELAE 2104
L+R+HE F L A QD+ E AAL + L L V R + + + L +
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
Query: 2105 SRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKH 2156
R AL L F + A +W+ + L++ + + L H
Sbjct: 506 KRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565
Query: 2157 QAFEAEV-QAHEEVMTSVAKKGE-ALLAQSH-----PRAGEVSQRLQGLRKHWEDLRQAM 2209
F+A + +A E + +GE + Q++ ++ Q + W+ +R+ +
Sbjct: 566 DQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLV 625
Query: 2210 ALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239
R Q L++ R+ E L+R A+A WIQ K
Sbjct: 626 PSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
Score = 39.3 bits (90), Expect = 0.072
Identities = 67/353 (18%), Positives = 135/353 (38%), Gaps = 39/353 (11%)
Query: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEI 1116
QR + AE +++ L E+ W + L ++ S + + LLR H+ ++
Sbjct: 404 QRLQHLAEKFRQKASLHEA-----WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
Query: 1117 HLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQ 1176
Q+R++ + A +Q + LD ++ V + + + Q L L ++R+ L+ ++
Sbjct: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE---RME 515
Query: 1177 KFGREVD----GFTATCANHQAWLHLDNLGED---------VREALSLLQQHREFGRLLS 1223
K +D F A W LD ED V E SLL H +F L
Sbjct: 516 KLLETIDQLQLEFARRAAPFNNW--LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP 573
Query: 1224 TLG-PRAEALRAHGE--KLVQSQ--HPAAHT--VREQLQSIQAQW--------TRLQGRS 1268
R + GE K+ Q+ P + + Q I +W +R Q
Sbjct: 574 EADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
E+ RQ + +++ + W++ K +G ++ + + E ++
Sbjct: 634 EELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNII 693
Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQ 1381
+ +++ L+ + L + ++ +R WE L + +E++
Sbjct: 694 NYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVE 746
Score = 34.7 bits (78), Expect = 1.8
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSV-SDVELLLHRHQDLEKLLAAQEEK 3440
+K RQ+ EAW E +L + DY ++ +V LL RH+ E LAA +++
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 344 bits (882), Expect = 1e-93
Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE L P RG++RVH
Sbjct: 31 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 89 KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVNI +F SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
PL NL AF VAE+ L I ++LD ED V A+PDE++IMTYVS +YH S + +T
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L YE+L +DLL WI LE R +++ AM+Q L F +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE E
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L + +L+RL+ LA +F+ KA++ E++ E +L Q A+L+ ++A +++
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E+ + + R + +A IA L + Y+ V R +++ +W L Q +R+ +
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499
Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
+ +L + ++ AA ++ +E E + T + E+ L H+ +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556
Score = 54.3 bits (129), Expect = 2e-06
Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
+ LE+++R W++ + + + + Q LE R++R V + C
Sbjct: 285 DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334
Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
I+ +LQ K R P E +++ S +NN W Y++ L EI
Sbjct: 335 EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388
Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
L R LD++ ++ ++K ++ +A GK+ L ++ LL+KHE E ++
Sbjct: 389 LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Q +VE + L + + + R Q++ + W L + QKRREAL+ + +KL
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504
Query: 2442 AMLQEL 2447
+ +L
Sbjct: 505 ETIDQL 510
Score = 47.4 bits (111), Expect = 3e-04
Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Q + + ++ Q + L AF+ + D+ L Q K E L
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
LE L + FR A AW K + +DY + LS ++ L ++H+ ES++++H+
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + ++ + V AR Q++ +L A +RR L++ ++ + +
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508
Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
+L +W+ L + H+ E Q L E K L
Sbjct: 509 QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 45.4 bits (106), Expect = 0.001
Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)
Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
LE + LQ+ + P + S+ + + G L+QV+ E + RR +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+ F Q++ W + +A LR K+ + ++ + LL++H+ ++ Q+R++Q
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
+ A +Q + LD DS V + + Q L L ++R++ L+ +K +D
Sbjct: 454 IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510
Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
A A W+ +++L + + E L H +F L R L
Sbjct: 511 YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570
Query: 1234 AHGE--KLVQSQH 1244
H E K+VQ+ H
Sbjct: 571 IHNEVSKIVQTYH 583
Score = 43.5 bits (101), Expect = 0.004
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
L F Q A+ E W L++ ++K LLK H+AFE+++ AH++ + +
Sbjct: 395 LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
A + L + + V+ R Q + W++L R + LE LE + ++ L
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 2234 A 2234
A
Sbjct: 515 A 515
Score = 42.0 bits (97), Expect = 0.011
Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
+ L+ + F E W KE L + L+ ++ LL KH+ E DL
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
++ + A A+ L++ + ++ S RCQ + + + L RR LE +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 41.6 bits (96), Expect = 0.015
Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)
Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
AQ E A R+ + +E Q + S LL++ R + W++ ++P
Sbjct: 252 AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
Q L R + H+ + + + L T +L F E
Sbjct: 309 MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
++Q+EK RR L E + + EA W + +L +D +
Sbjct: 369 GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426
Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
+ALL++ EA + DL A R+E++ A L +SP V A+ Q + +
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
A + R A R L E + LE + + W+ + A + QD +++
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544
Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
+G+ E+F DA ++ + LG + K+ T P+ I
Sbjct: 545 QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 3158 AWERLDQAIKARTENLAAAH 3177
W+ + Q + R + L H
Sbjct: 603 KWDHVRQLVPRRDQALTEEH 622
Score = 40.8 bits (94), Expect = 0.025
Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
EQ++ +W +E RR + L L ++++Q + W + K M + +
Sbjct: 372 EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426
Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
I LK+HEA ES+L A + VE + + +EL + R Q + +W+ L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
+R + L++ + + + QL + A +EGA LQ + + Q
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 1422 LQKRHQQLES 1431
L H+Q ++
Sbjct: 547 LTTAHEQFKA 556
Score = 39.3 bits (90), Expect = 0.072
Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)
Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
L+E+ LL++H+ E+ ++AH V +A EL+ + A+ + + +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
AL + RR LE+T + E + E A W++ + + + + + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 642 ALQKHKALEA 651
H+ +A
Sbjct: 547 LTTAHEQFKA 556
Score = 38.5 bits (88), Expect = 0.12
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
CL+++E +E W L R E +K RQ+ EAW E +L + DY +
Sbjct: 370 CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425
Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
+S+++ LL +H+ E LAA +++ Q+ E
Sbjct: 426 TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460
Score = 38.1 bits (87), Expect = 0.16
Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)
Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
+D R +RL K + QLE TL K M + M + + LE+
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
+K +RRLE L HLA +F +++ +W
Sbjct: 374 VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Y T L+ ++L +KH+ + ++ AHQ +V+++ + + L + + + +CQ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
W L + R + L++ T Q +L+ ++ W+E
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526
Score = 38.1 bits (87), Expect = 0.16
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)
Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
++WL E L++ + F + H+AW D + E +LL++H
Sbjct: 379 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
F L+ R E + A ++L + + + +V + Q I QW L +++RR L
Sbjct: 439 AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+ +L E+ + A WME GA ++ T H E + L
Sbjct: 499 RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547
Query: 1329 AT 1330
T
Sbjct: 548 TT 549
Score = 37.0 bits (84), Expect = 0.36
Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)
Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
R C+ A + + Y S+L W+ P + +R ++ R
Sbjct: 261 RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
++K +QE +L I ++++ QT L+ +P + R+V + L + +
Sbjct: 321 RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376
Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+E R LE L E R+ + + W ++ + + L K
Sbjct: 377 GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
F+ + RV +A+ L E + P V R Q + W L LTQ R A
Sbjct: 437 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496
Query: 1798 LRDTETTL 1805
L TE L
Sbjct: 497 LERTEKLL 504
Score = 34.3 bits (77), Expect = 2.3
Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)
Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
+ ++D +++A+ W+R + + LE + + M Q QK ++F+ +H+ ++
Sbjct: 273 EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328
Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
Q + Q +L PA + R+ ++ WG L+ N ++
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
+ +L E R + S+ E W + E LR A L + LL E+ +
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
+ E + AQ + + V + +++ ++ +L Q+RR ALE LL+
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
E A W++ + ++ ++ L H+ ++ + +
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
+LG K+VQ H Q++ H+R RR L + Q
Sbjct: 567 AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626
Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
QF + G W+ + + S +M + E + LR+ E + + + P
Sbjct: 627 HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683
Query: 3019 RIERLQQTAALLE 3031
+I++L+ L++
Sbjct: 684 KIDQLEGDHQLIQ 696
Score = 33.9 bits (76), Expect = 3.0
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)
Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
S G MV D+ AW E W L + R L R + E T
Sbjct: 356 SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411
Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
+E + L ++A L+ H+ E +L + +++++ A + +L +
Sbjct: 412 GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470
Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
+V R Q + W L ++RR LER +LL +YA +W +
Sbjct: 471 SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530
Query: 1930 DLQ 1932
DLQ
Sbjct: 531 DLQ 533
Score = 32.3 bits (72), Expect = 8.8
Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)
Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
+LER LA +FR + +W L Q + + S L H+ ++L A
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
+ +Q + Q+ + V + + DQ D + +++E L+ ++
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
+QL+L R + L+ + + ++EE++ L HE F L DK+ A
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 2073 L 2073
+
Sbjct: 568 I 568
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 344 bits (882), Expect = 1e-93
Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE L P RG++RVH
Sbjct: 31 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 89 KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVNI +F SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
PL NL AF VAE+ L I ++LD ED V A+PDE++IMTYVS +YH S + +T
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L YE+L +DLL WI LE R +++ AM+Q L F +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE E
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L + +L+RL+ LA +F+ KA++ E++ E +L Q A+L+ ++A +++
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E+ + + R + +A IA L + Y+ V R +++ +W L Q +R+ +
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499
Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
+ +L + ++ AA ++ +E E + T + E+ L H+ +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556
Score = 54.3 bits (129), Expect = 2e-06
Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
+ LE+++R W++ + + + + Q LE R++R V + C
Sbjct: 285 DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334
Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
I+ +LQ K R P E +++ S +NN W Y++ L EI
Sbjct: 335 EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388
Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
L R LD++ ++ ++K ++ +A GK+ L ++ LL+KHE E ++
Sbjct: 389 LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Q +VE + L + + + R Q++ + W L + QKRREAL+ + +KL
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504
Query: 2442 AMLQEL 2447
+ +L
Sbjct: 505 ETIDQL 510
Score = 47.4 bits (111), Expect = 3e-04
Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Q + + ++ Q + L AF+ + D+ L Q K E L
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
LE L + FR A AW K + +DY + LS ++ L ++H+ ES++++H+
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + ++ + V AR Q++ +L A +RR L++ ++ + +
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508
Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
+L +W+ L + H+ E Q L E K L
Sbjct: 509 QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 45.4 bits (106), Expect = 0.001
Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)
Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
LE + LQ+ + P + S+ + + G L+QV+ E + RR +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+ F Q++ W + +A LR K+ + ++ + LL++H+ ++ Q+R++Q
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
+ A +Q + LD DS V + + Q L L ++R++ L+ +K +D
Sbjct: 454 IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510
Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
A A W+ +++L + + E L H +F L R L
Sbjct: 511 YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570
Query: 1234 AHGE--KLVQSQH 1244
H E K+VQ+ H
Sbjct: 571 IHNEVSKIVQTYH 583
Score = 43.5 bits (101), Expect = 0.004
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
L F Q A+ E W L++ ++K LLK H+AFE+++ AH++ + +
Sbjct: 395 LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
A + L + + V+ R Q + W++L R + LE LE + ++ L
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 2234 A 2234
A
Sbjct: 515 A 515
Score = 42.0 bits (97), Expect = 0.011
Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
+ L+ + F E W KE L + L+ ++ LL KH+ E DL
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
++ + A A+ L++ + ++ S RCQ + + + L RR LE +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 41.6 bits (96), Expect = 0.015
Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)
Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
AQ E A R+ + +E Q + S LL++ R + W++ ++P
Sbjct: 252 AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
Q L R + H+ + + + L T +L F E
Sbjct: 309 MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
++Q+EK RR L E + + EA W + +L +D +
Sbjct: 369 GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426
Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
+ALL++ EA + DL A R+E++ A L +SP V A+ Q + +
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
A + R A R L E + LE + + W+ + A + QD +++
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544
Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
+G+ E+F DA ++ + LG + K+ T P+ I
Sbjct: 545 QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 3158 AWERLDQAIKARTENLAAAH 3177
W+ + Q + R + L H
Sbjct: 603 KWDHVRQLVPRRDQALTEEH 622
Score = 40.8 bits (94), Expect = 0.025
Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
EQ++ +W +E RR + L L ++++Q + W + K M + +
Sbjct: 372 EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426
Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
I LK+HEA ES+L A + VE + + +EL + R Q + +W+ L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
+R + L++ + + + QL + A +EGA LQ + + Q
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 1422 LQKRHQQLES 1431
L H+Q ++
Sbjct: 547 LTTAHEQFKA 556
Score = 39.3 bits (90), Expect = 0.072
Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)
Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
L+E+ LL++H+ E+ ++AH V +A EL+ + A+ + + +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
AL + RR LE+T + E + E A W++ + + + + + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 642 ALQKHKALEA 651
H+ +A
Sbjct: 547 LTTAHEQFKA 556
Score = 38.5 bits (88), Expect = 0.12
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
CL+++E +E W L R E +K RQ+ EAW E +L + DY +
Sbjct: 370 CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425
Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
+S+++ LL +H+ E LAA +++ Q+ E
Sbjct: 426 TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460
Score = 38.1 bits (87), Expect = 0.16
Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)
Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
+D R +RL K + QLE TL K M + M + + LE+
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
+K +RRLE L HLA +F +++ +W
Sbjct: 374 VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Y T L+ ++L +KH+ + ++ AHQ +V+++ + + L + + + +CQ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
W L + R + L++ T Q +L+ ++ W+E
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526
Score = 38.1 bits (87), Expect = 0.16
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)
Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
++WL E L++ + F + H+AW D + E +LL++H
Sbjct: 379 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
F L+ R E + A ++L + + + +V + Q I QW L +++RR L
Sbjct: 439 AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+ +L E+ + A WME GA ++ T H E + L
Sbjct: 499 RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547
Query: 1329 AT 1330
T
Sbjct: 548 TT 549
Score = 37.0 bits (84), Expect = 0.36
Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)
Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
R C+ A + + Y S+L W+ P + +R ++ R
Sbjct: 261 RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
++K +QE +L I ++++ QT L+ +P + R+V + L + +
Sbjct: 321 RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376
Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+E R LE L E R+ + + W ++ + + L K
Sbjct: 377 GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
F+ + RV +A+ L E + P V R Q + W L LTQ R A
Sbjct: 437 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496
Query: 1798 LRDTETTL 1805
L TE L
Sbjct: 497 LERTEKLL 504
Score = 34.3 bits (77), Expect = 2.3
Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)
Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
+ ++D +++A+ W+R + + LE + + M Q QK ++F+ +H+ ++
Sbjct: 273 EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328
Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
Q + Q +L PA + R+ ++ WG L+ N ++
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
+ +L E R + S+ E W + E LR A L + LL E+ +
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
+ E + AQ + + V + +++ ++ +L Q+RR ALE LL+
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
E A W++ + ++ ++ L H+ ++ + +
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
+LG K+VQ H Q++ H+R RR L + Q
Sbjct: 567 AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626
Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
QF + G W+ + + S +M + E + LR+ E + + + P
Sbjct: 627 HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683
Query: 3019 RIERLQQTAALLE 3031
+I++L+ L++
Sbjct: 684 KIDQLEGDHQLIQ 696
Score = 33.9 bits (76), Expect = 3.0
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)
Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
S G MV D+ AW E W L + R L R + E T
Sbjct: 356 SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411
Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
+E + L ++A L+ H+ E +L + +++++ A + +L +
Sbjct: 412 GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470
Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
+V R Q + W L ++RR LER +LL +YA +W +
Sbjct: 471 SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530
Query: 1930 DLQ 1932
DLQ
Sbjct: 531 DLQ 533
Score = 32.3 bits (72), Expect = 8.8
Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)
Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
+LER LA +FR + +W L Q + + S L H+ ++L A
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
+ +Q + Q+ + V + + DQ D + +++E L+ ++
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
+QL+L R + L+ + + ++EE++ L HE F L DK+ A
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 2073 L 2073
+
Sbjct: 568 I 568
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 344 bits (882), Expect = 1e-93
Identities = 204/537 (37%), Positives = 307/537 (57%), Gaps = 21/537 (3%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE L P RG++RVH
Sbjct: 31 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVH 88
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 89 KISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET---- 144
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVNI +F SW DGLGF ALIH HRP+L+DYG LR D
Sbjct: 145 -----SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKD 199
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
PL NL AF VAE+ L I ++LD ED V A+PDE++IMTYVS +YH S + +T
Sbjct: 200 DPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAA 259
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L YE+L +DLL WI LE R +++ AM+Q L F +
Sbjct: 260 NRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY 319
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE E
Sbjct: 320 RRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L + +L+RL+ LA +F+ KA++ E++ E +L Q A+L+ ++A +++
Sbjct: 380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEA 439
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
E+ + + R + +A IA L + Y+ V R +++ +W L Q +R+ +
Sbjct: 440 FESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALER 499
Query: 497 MQAVLSLLQEV------EAA--SHQLEELQEPARSTACGQQLAEVVELLQRHDLLEA 545
+ +L + ++ AA ++ +E E + T + E+ L H+ +A
Sbjct: 500 TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKA 556
Score = 54.3 bits (129), Expect = 2e-06
Identities = 59/246 (23%), Positives = 109/246 (44%), Gaps = 39/246 (15%)
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
+ LE+++R W++ + + + + Q LE R++R V + C
Sbjct: 285 DLLEWIRRTI---PWLENRVPENTMHAMQQKLED-------FRDYRRLHKPPKVQEKCQL 334
Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
I+ +LQ K R P E +++ S +NN W Y++ L EI
Sbjct: 335 EINFNTLQTKLRLSNRPAFMPSEGRMV----SDINNAWGCLEQVEKGYEEWLLN--EIRR 388
Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
L R LD++ ++ ++K ++ +A GK+ L ++ LL+KHE E ++
Sbjct: 389 LER-LDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Q +VE + L + + + R Q++ + W L + QKRREAL+ + +KL
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLL 504
Query: 2442 AMLQEL 2447
+ +L
Sbjct: 505 ETIDQL 510
Score = 47.4 bits (111), Expect = 3e-04
Identities = 49/230 (21%), Positives = 92/230 (40%), Gaps = 10/230 (4%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Q + + ++ Q + L AF+ + D+ L Q K E L
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
LE L + FR A AW K + +DY + LS ++ L ++H+ ES++++H+
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + ++ + V AR Q++ +L A +RR L++ ++ + +
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID 508
Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
+L +W+ L + H+ E Q L E K L
Sbjct: 509 QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 45.4 bits (106), Expect = 0.001
Identities = 57/253 (22%), Positives = 107/253 (42%), Gaps = 24/253 (9%)
Query: 1013 LERRVHFLQSVVVKVEEPGYAESQP-LQGQVETLQGLLKQVQ----EQVAQRARR-QAET 1066
LE + LQ+ + P + S+ + + G L+QV+ E + RR +
Sbjct: 334 LEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLD 393
Query: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
+ F Q++ W + +A LR K+ + ++ + LL++H+ ++ Q+R++Q
Sbjct: 394 HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQ 453
Query: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
+ A +Q + LD DS V + + Q L L ++R++ L+ +K +D
Sbjct: 454 IAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE---RTEKLLETIDQL 510
Query: 1186 TATCANHQA----WLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLG-PRAEALR 1233
A A W+ +++L + + E L H +F L R L
Sbjct: 511 YLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG 570
Query: 1234 AHGE--KLVQSQH 1244
H E K+VQ+ H
Sbjct: 571 IHNEVSKIVQTYH 583
Score = 43.5 bits (101), Expect = 0.004
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
L F Q A+ E W L++ ++K LLK H+AFE+++ AH++ + +
Sbjct: 395 LAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAE 2233
A + L + + V+ R Q + W++L R + LE LE + ++ L
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 2234 A 2234
A
Sbjct: 515 A 515
Score = 42.0 bits (97), Expect = 0.011
Identities = 41/175 (23%), Positives = 73/175 (41%), Gaps = 4/175 (2%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 330 EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE-EWLLNEIRR 388
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
+ L+ + F E W KE L + L+ ++ LL KH+ E DL
Sbjct: 389 LERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
++ + A A+ L++ + ++ S RCQ + + + L RR LE +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 41.6 bits (96), Expect = 0.015
Identities = 79/380 (20%), Positives = 139/380 (36%), Gaps = 37/380 (9%)
Query: 2826 AQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQD 2885
AQ E A R+ + +E Q + S LL++ R + W++ ++P
Sbjct: 252 AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIR---RTIPWLENRVPENTMHA 308
Query: 2886 YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---------VA 2936
Q L R + H+ + + + L T +L F E
Sbjct: 309 MQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAW 368
Query: 2937 ARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA 2996
++Q+EK RR L E + + EA W + +L +D +
Sbjct: 369 GCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETAT 426
Query: 2997 -EATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE----- 3050
+ALL++ EA + DL A R+E++ A L +SP V A+ Q + +
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 3051 -AHAELLRRAEARGHGLQEQLQLHQLE--RETLLLDAWLTTKAATAESQDYG-----QDL 3102
A + R A R L E + LE + + W+ + A + QD +++
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM--EGAMEDLQDTFIVHTIEEI 544
Query: 3103 EGVKVLEEKF-----DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
+G+ E+F DA ++ + LG + K+ T P+ I
Sbjct: 545 QGLTTAHEQFKATLPDADKERLAILGIHN--EVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 3158 AWERLDQAIKARTENLAAAH 3177
W+ + Q + R + L H
Sbjct: 603 KWDHVRQLVPRRDQALTEEH 622
Score = 40.8 bits (94), Expect = 0.025
Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 15/190 (7%)
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGA 1309
EQ++ +W +E RR + L L ++++Q + W + K M + +
Sbjct: 372 EQVEKGYEEWLL----NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLRQKDYETAT 426
Query: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
I LK+HEA ES+L A + VE + + +EL + R Q + +W+ L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 1370 NRKMTERGDELQQAGQQEQLLRQL-----QDAKEQLEQLEGA---LQSSETGQDLRSSQR 1421
+R + L++ + + + QL + A +EGA LQ + + Q
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 1422 LQKRHQQLES 1431
L H+Q ++
Sbjct: 547 LTTAHEQFKA 556
Score = 39.3 bits (90), Expect = 0.072
Identities = 29/130 (22%), Positives = 58/130 (44%), Gaps = 8/130 (6%)
Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
L+E+ LL++H+ E+ ++AH V +A EL+ + A+ + + +L
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL 486
Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
AL + RR LE+T + E + E A W++ + + + + + +I G
Sbjct: 487 GALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG 546
Query: 642 ALQKHKALEA 651
H+ +A
Sbjct: 547 LTTAHEQFKA 556
Score = 38.5 bits (88), Expect = 0.12
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 3359 CLQELEGRLQELEEAWALRWQRCAESWG--LQKLRQRLEQAEAWLACWEGLLLKPDYGHS 3416
CL+++E +E W L R E +K RQ+ EAW E +L + DY +
Sbjct: 370 CLEQVEKGYEE----WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETA 425
Query: 3417 -VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
+S+++ LL +H+ E LAA +++ Q+ E
Sbjct: 426 TLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQE 460
Score = 38.1 bits (87), Expect = 0.16
Identities = 48/226 (21%), Positives = 91/226 (40%), Gaps = 44/226 (19%)
Query: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
+D R +RL K + QLE TL K M + M + + LE+
Sbjct: 314 EDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQ 373
Query: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
+K +RRLE L HLA +F +++ +W
Sbjct: 374 VEKGYEEWLLNEIRRLERLD-HLA------------EKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1512 SY-TECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Y T L+ ++L +KH+ + ++ AHQ +V+++ + + L + + + +CQ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1571 GHWAELERACEARAQCLQQA----VTFQQYFLDVSE----LEGWVE 1608
W L + R + L++ T Q +L+ ++ W+E
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 526
Score = 38.1 bits (87), Expect = 0.16
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 28/182 (15%)
Query: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHR 1216
++WL E L++ + F + H+AW D + E +LL++H
Sbjct: 379 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHE 438
Query: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL 1276
F L+ R E + A ++L + + + +V + Q I QW L +++RR L
Sbjct: 439 AFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Query: 1277 ASLQL--------QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+ +L E+ + A WME GA ++ T H E + L
Sbjct: 499 RTEKLLETIDQLYLEYAKRAAPFNNWME-----------GAMEDLQDTFIVHTIEEIQGL 547
Query: 1329 AT 1330
T
Sbjct: 548 TT 549
Score = 37.0 bits (84), Expect = 0.36
Identities = 53/248 (21%), Positives = 91/248 (36%), Gaps = 24/248 (9%)
Query: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSR---------DYGRDEAATLR 1628
R C+ A + + Y S+L W+ P + +R ++ R
Sbjct: 261 RICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYR 320
Query: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQER------LREQLR 1678
++K +QE +L I ++++ QT L+ +P + R+V + L + +
Sbjct: 321 RLHKPPKVQEKCQLEINFNTL----QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEK 376
Query: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+E R LE L E R+ + + W ++ + + L K
Sbjct: 377 GYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKK 436
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
F+ + RV +A+ L E + P V R Q + W L LTQ R A
Sbjct: 437 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREA 496
Query: 1798 LRDTETTL 1805
L TE L
Sbjct: 497 LERTEKLL 504
Score = 34.3 bits (77), Expect = 2.3
Identities = 81/433 (18%), Positives = 165/433 (38%), Gaps = 60/433 (13%)
Query: 2650 QAFLQDSQEVAA----WLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL 2705
+ ++D +++A+ W+R + + LE + + M Q QK ++F+ +H+ ++
Sbjct: 273 EQLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHAMQ-QKLEDFRDY--RRLHKPPKV 328
Query: 2706 QREGQ----------RLLQGGHPASEAIQERL-EELGALWGELQD----------NSQKK 2744
Q + Q +L PA + R+ ++ WG L+ N ++
Sbjct: 329 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRR 388
Query: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQA-LPGVGELLGTQRELEAAVDK 2803
+ +L E R + S+ E W + E LR A L + LL E+ +
Sbjct: 389 LERLDHLAEKFRQKASIHEA--WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA 446
Query: 2804 KARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKF 2863
+ E + AQ + + V + +++ ++ +L Q+RR ALE LL+
Sbjct: 447 HQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET 506
Query: 2864 FRDADEEMA--------WVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTR 2915
E A W++ + ++ ++ L H+ ++ + +
Sbjct: 507 IDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL 566
Query: 2916 VVLGTG---YKLVQAGHF----AAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQ- 2967
+LG K+VQ H Q++ H+R RR L + Q
Sbjct: 567 AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQ 626
Query: 2968 -------QFLTELLEAGSWLAERGHVLD--SEDMGHSAEATQALLRRLEATKRDLEAFSP 3018
QF + G W+ + + S +M + E + LR+ E + + + P
Sbjct: 627 HNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYE---KSIVNYKP 683
Query: 3019 RIERLQQTAALLE 3031
+I++L+ L++
Sbjct: 684 KIDQLEGDHQLIQ 696
Score = 33.9 bits (76), Expect = 3.0
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 23/183 (12%)
Query: 1768 SAGPMVRQRQQDLQTAWS---------ELWELTQARG-HALRDTETTLRVHRDLLEVLTQ 1817
S G MV D+ AW E W L + R L R + E T
Sbjct: 356 SEGRMV----SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 411
Query: 1818 VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAH 1877
+E + L ++A L+ H+ E +L + +++++ A + +L +
Sbjct: 412 GKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNEL-DYYDSP 470
Query: 1878 AVQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYA-------SWAARVRQ 1929
+V R Q + W L ++RR LER +LL +YA +W +
Sbjct: 471 SVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAME 530
Query: 1930 DLQ 1932
DLQ
Sbjct: 531 DLQ 533
Score = 32.3 bits (72), Expect = 8.8
Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 10/181 (5%)
Query: 1903 QLERARLLA-RFRTAVRDYASWAARVRQDL-QVEESSQEPSSGPLKLSAHQWLRAELEAR 1960
+LER LA +FR + +W L Q + + S L H+ ++L A
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 1961 EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ----- 2015
+ +Q + Q+ + V + + DQ D + +++E L+ ++
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI 507
Query: 2016 EQLFLRECGRLEEI---LAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAA 2072
+QL+L R + L+ + + ++EE++ L HE F L DK+ A
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA 567
Query: 2073 L 2073
+
Sbjct: 568 I 568
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 338 bits (866), Expect = 7e-92
Identities = 201/533 (37%), Positives = 302/533 (56%), Gaps = 21/533 (3%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE LP P RG++RVH
Sbjct: 50 KQQRKTFTAWCNSHLR--KAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVH 107
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 108 KINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEET---- 163
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
S KE LL+WCQRKTA Y NVN+ +F SW DGL FNALIH HRP+L++Y LR D
Sbjct: 164 -----SAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKD 218
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
P+ NL AF VAE+ L I ++LD ED+ A+PDE++IMTYVS +YH S + +T
Sbjct: 219 DPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAA 278
Query: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
R+ K+L QE E L YE+L +DLL WI LE R ++ M+Q L F +
Sbjct: 279 NRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDY 338
Query: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE AE
Sbjct: 339 RRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE 398
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L + +L+RL+ LA +F+ KA++ E++ E +L A+L+ ++A +++
Sbjct: 399 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEA 458
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL--LQH-----LQG 489
E+ + + R + +A IA L + Y+ +V R +++ +W L L H L+
Sbjct: 459 FESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEK 518
Query: 490 QRKQV-ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
KQ+ A Q L + ++ +E E + + E+ L+ HD
Sbjct: 519 TEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD 571
Score = 60.1 bits (144), Expect = 4e-08
Identities = 63/252 (25%), Positives = 114/252 (45%), Gaps = 38/252 (15%)
Query: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
+ LE+++R W++++ + + ++ Q LE R++R V + C
Sbjct: 304 DLLEWIRRTI---PWLEDRVPQKTIQEMQQKLED-------FRDYRRVHKPPKVQEKCQL 353
Query: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
I+ +LQ K R P E K++ S +NN W Y++ L EI
Sbjct: 354 EINFNTLQTKLRLSNRPAFMPSEGKMV----SDINNGWQHLEQAEKGYEEWLLN--EIRR 407
Query: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
L R LD++ ++ ++K ++ +A GK+ L ++ L+RKHE E ++
Sbjct: 408 LER-LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
Query: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Q +VE + L + +H + R Q++ + W L S RREAL+ ++L+
Sbjct: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE--KQLE 524
Query: 2442 AMLQELLVSAQR 2453
A+ Q L A+R
Sbjct: 525 AIDQLHLEYAKR 536
Score = 58.2 bits (139), Expect = 1e-07
Identities = 84/401 (20%), Positives = 160/401 (39%), Gaps = 41/401 (10%)
Query: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHK------ELQVEVKAHQGQVQRVLSSGRSL 1551
+ W+ + +P + + L + R HK + Q+E+ + Q + LS+ +
Sbjct: 313 IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAF 372
Query: 1552 AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL-EGWVEEK 1610
S I Q LE E + L++ + F + + E W + K
Sbjct: 373 MPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGK 432
Query: 1611 RPLVSSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
++ RDY E ATL LI KH+A + +LA + +E++ AQ L + +
Sbjct: 433 EAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH 489
Query: 1667 RVVQ--ERLREQLRALQELAATR-------DRELEGTLRLH-EFLREAEDLQGWLASQKQ 1716
V +++ +Q AL L +R +++LE +LH E+ + A W+ S +
Sbjct: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
Query: 1717 AAKGGESLG--EDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGH----SAG 1770
+ + E+ E + +F + + + A A+ + E H +
Sbjct: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
Query: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822
P Q + + W ++ +L R HAL + ++ + + L +Q K
Sbjct: 610 PYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM 669
Query: 1823 TSLPNNVARDLCG-LEAQLRSHQGLERELVGTERQLQELLE 1862
+ ++ ++ G LE QL + ER +V + L +LLE
Sbjct: 670 EEI-GRISIEMNGTLEDQLSHLKQYERSIVDYKPNL-DLLE 708
Score = 50.4 bits (119), Expect = 3e-05
Identities = 80/408 (19%), Positives = 154/408 (37%), Gaps = 36/408 (8%)
Query: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Q + + ++ Q + L AF+ + D+ + L Q K E L
Sbjct: 348 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRR 407
Query: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
LE L + FR A AW K + +DY + LS ++ L +H+ ES++++H+
Sbjct: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467
Query: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
+ +L + ++ +H V R Q++ L + RR L++ ++ + +
Sbjct: 468 DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527
Query: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATK-------RDLEAF 3016
+L +W+ L + H+ E + L+ + K R+ EA
Sbjct: 528 QLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAI 587
Query: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
+ Q+ A + + +P Q + ++ + R H L E+ Q Q
Sbjct: 588 LAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE-QSKQQS 646
Query: 3077 RETL---------LLDAWLTTKAATAESQDYGQ-DLEGVKVLEEKFDAFRKEVQSLGQAK 3126
E L ++ W+ TK ++ G+ +E LE++ ++ +S+ K
Sbjct: 647 NEHLRRQFASQANVVGPWIQTK-----MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYK 701
Query: 3127 --VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
+ L + ++ H I WE+L I ART N
Sbjct: 702 PNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTI-ARTIN 748
Score = 48.9 bits (115), Expect = 9e-05
Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 49/276 (17%)
Query: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVR 1206
Q L+ + ++WL E L++ + F + H+AW H D +
Sbjct: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLS 447
Query: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
+ +L+++H F L+ R E + A ++L + + +H V + Q I QW L
Sbjct: 448 DIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGS 507
Query: 1267 RSEQRR-------RQLLASLQLQ-EWKQDVAELMQWMEE-----------------KGLM 1301
+ RR +QL A QL E+ + A WME +GL+
Sbjct: 508 LTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI 567
Query: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-RLQ 1360
+AH+ TL + +LA + + + + LS G T Q
Sbjct: 568 SAHD------QFKSTLPDADREREAILAIHKEAQRIAESNHIKLS----GSNPYTTVTPQ 617
Query: 1361 GLRSKWEALNRKMTERGDEL--QQAGQQ--EQLLRQ 1392
+ SKWE + + + +R L +Q+ QQ E L RQ
Sbjct: 618 IINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653
Score = 48.1 bits (113), Expect = 2e-04
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 31/268 (11%)
Query: 1268 SEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGARRNILQTLKRHEAAES 1325
+E RR + L L ++++Q + W + K M H + +I +++HEA ES
Sbjct: 403 NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFES 461
Query: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
+L A + VE + + +EL ++ TR Q + +W+AL R + L++ +
Sbjct: 462 DLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Query: 1386 QEQLLRQL---------------QDAKEQL---------EQLEGALQSSETGQD-LRSSQ 1420
Q + + QL + A E L E++EG + + + + L +
Sbjct: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Query: 1421 RLQKRHQQLESESRTLA-AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGL 1479
R ++ + E++ +A + L+ +P I+ + +++L + H +
Sbjct: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
Query: 1480 QLQASVE--LHQFCHLSNMELSWVAEHM 1505
Q S E QF +N+ W+ M
Sbjct: 642 SKQQSNEHLRRQFASQANVVGPWIQTKM 669
Score = 46.2 bits (108), Expect = 6e-04
Identities = 63/330 (19%), Positives = 139/330 (42%), Gaps = 36/330 (10%)
Query: 1070 QSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
+ F Q++ W + +A L+ ++ + ++ + L+R+H+ ++ Q+R++Q+ A
Sbjct: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475
Query: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDGFTA 1187
+Q + LD DS V + + Q L L R++ L++ +L+ + +
Sbjct: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
Query: 1188 TCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA---HGE 1237
A W+ +++L + + E L+ H +F L EA+ A +
Sbjct: 536 RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595
Query: 1238 KLVQSQHPAAH------TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE- 1290
++ +S H TV Q+ I ++W ++Q +R LL Q+ + +
Sbjct: 596 RIAESNHIKLSGSNPYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653
Query: 1291 -----------LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
+ MEE G ++ E +G + L LK++E + ++ + +++ L+Q
Sbjct: 654 FASQANVVGPWIQTKMEEIGRISI-EMNGTLEDQLSHLKQYERS---IVDYKPNLDLLEQ 709
Query: 1340 VGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
+ + + ++ +R WE L
Sbjct: 710 QHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739
Score = 43.9 bits (102), Expect = 0.003
Identities = 67/316 (21%), Positives = 130/316 (41%), Gaps = 44/316 (13%)
Query: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS-VEE 2048
+Q ++ Y+ W R+ ERL + + F ++ E +E LK ++ + +
Sbjct: 391 EQAEKGYEEWLLNEIRRLERL--DHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD 448
Query: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102
++ LIRKHE F L A QD+ E AA+ + L L V R + + + L
Sbjct: 449 IKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSL 508
Query: 2103 AESRGHALHAS--------LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154
SR AL + L + + A +W+++ + L++ + + +
Sbjct: 509 THSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLIS 568
Query: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAG----EVSQRLQGLRKHWEDLRQ 2207
H F++ + E + ++ K+ + + +H + + Q + WE ++Q
Sbjct: 569 AHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQ 628
Query: 2208 AMALRGQEL---EDRRNFLEFLQRVDLAEA-----WIQEK-------EVKMNVGDLGQDL 2252
+ R L + ++ E L+R ++A WIQ K ++MN G L L
Sbjct: 629 LVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMN-GTLEDQL 687
Query: 2253 EHCLQLRRRLREFRGN 2268
H Q R + +++ N
Sbjct: 688 SHLKQYERSIVDYKPN 703
Score = 42.7 bits (99), Expect = 0.007
Identities = 45/187 (24%), Positives = 81/187 (43%), Gaps = 5/187 (2%)
Query: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 349 EKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE-EWLLNEIRR 407
Query: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
+ L+ + F E W KE L L+ ++ L+ KH+ E DL
Sbjct: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467
Query: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL-RQLQAFL 2653
++ + A A+ L++ + ++ + RCQ + + +AL +RR LE+ +QL+A
Sbjct: 468 DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527
Query: 2654 QDSQEVA 2660
Q E A
Sbjct: 528 QLHLEYA 534
Score = 40.4 bits (93), Expect = 0.032
Identities = 50/270 (18%), Positives = 104/270 (38%), Gaps = 32/270 (11%)
Query: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
L+++ L+++H+ E+ ++AH V +A EL+ + + + + +L
Sbjct: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505
Query: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
+L +RR LE+T ++ E + E A W++ + + + + + +I G
Sbjct: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565
Query: 642 ALQKH---KALEAEVHRHQAVCVDLVRRGR--------DLSARRPPTQPDPGERAEAVQG 690
+ H K+ + R + + + + + LS P T P + +
Sbjct: 566 LISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTP----QIINS 621
Query: 691 GWQLLQTRVVGRGARL--------QTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
W+ +Q V R L L Q+ + A W++ + + R S +
Sbjct: 622 KWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI-EMN 680
Query: 743 AAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
E L + ER + + L LE+Q
Sbjct: 681 GTLEDQLSHLKQYERSIVDYKPNLDLLEQQ 710
Score = 39.3 bits (90), Expect = 0.072
Identities = 39/169 (23%), Positives = 75/169 (44%), Gaps = 12/169 (7%)
Query: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQ-DLRQEGQQLVDNSH 3350
+ W ++R + +E+ + + H+ + +C+L+ + Q +L +
Sbjct: 313 IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQ-EKCQLEINFNTLQTKLRLSNRPA 371
Query: 3351 FMSAEVTECLQELEGRLQELEEA------WALRWQRCAESWG--LQKLRQRLEQAEAWLA 3402
FM +E + + ++ Q LE+A W L R E +K RQ+ EAW
Sbjct: 372 FMPSE-GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 430
Query: 3403 CWEGLLLKPDYGHS-VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
E +L DY + +SD++ L+ +H+ E LAA +++ Q+ E
Sbjct: 431 GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQE 479
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 269 bits (687), Expect = 4e-71
Identities = 184/643 (28%), Positives = 311/643 (48%), Gaps = 11/643 (1%)
Query: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
RH+A +EL + +E +++ G++L+ +P ++ +L +R W L +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
+L +A + +QL++ + ++L +E LQ + G DL + K+ Q +ES+
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 1439 KMAALASMAHGMAASPAILE---ETQKHL-RRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
++ L + + PA E E Q + RL L L R L AS ELHQ H
Sbjct: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
+ EL+WV E +P T L Q +K++ L+ E++AH +++ VL +LA+
Sbjct: 201 DDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL 260
Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
P+A+ + ++L+ WA L A E R Q L A +QY+ DV+E+E W+ E+ L+
Sbjct: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
Query: 1615 SSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVV--QER 1672
S D G+DE +TL+L+ KH L++ + Y S+ +L + + L P+ +++ Q +
Sbjct: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
Query: 1673 LREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHAL 1732
+ AL+EL R LE L++ R+ +L+ W+A +K+ G LG+D EH
Sbjct: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA-EKEVVAGSPELGQDFEHVS 439
Query: 1733 HLCTKFAKFQHQVEM-GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
L KF++F + M G +R+AA + + L+E GH+A + + + L AW+EL EL
Sbjct: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499
Query: 1792 QARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP--NNVARDLCGLEAQLRSHQGLERE 1849
R L + + D E+ Q++EK LP + R+ + E +
Sbjct: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHD 559
Query: 1850 LVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARL 1909
L Q+++L E A +++ + G A A+ R+Q V Q W L E R +
Sbjct: 560 LQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD 619
Query: 1910 LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
RF + VRD SW + + + + PSS L L A W
Sbjct: 620 ALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS-LLGLPASPW 661
Score = 248 bits (632), Expect = 1e-64
Identities = 177/624 (28%), Positives = 302/624 (48%), Gaps = 7/624 (1%)
Query: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736
D L + + Q F AEL + ++++REGQ+L+Q + +++++L E+ W E
Sbjct: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
Query: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRE 2796
L+ +Q K +L +A +A +L +S EL+ L +E +L+ G L V L +
Sbjct: 71 LESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS 130
Query: 2797 LEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEA 2856
+E+ V++ R+ L Q A E + V E+ + +R L EPLQERR L A
Sbjct: 131 MESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189
Query: 2857 RSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRV 2916
L + D D+E+AWVQE+LPLA + G L AV+ +++Q L E+ +H
Sbjct: 190 SKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEE 249
Query: 2917 VLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEA 2976
VL L A V ++QL+ A A LR A RR+ +L A + +Q+ ++ E
Sbjct: 250 VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
Query: 2977 GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNP 3036
+WL E+ ++ SED G ++T LL++ ++ +E + I +L + L +P
Sbjct: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
Query: 3037 ESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQ 3096
+S ++ + V + L E R L++Q L+QL R+ L+ W+ K A S
Sbjct: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
Query: 3097 DYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIE 3156
+ GQD E V VL+EKF F E G+ ++ A+ ++ L + + +
Sbjct: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
Query: 3157 AAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGEDGGHSLSSVRTL 3215
AW L + + R + LAA+ E+H F A ELQG+++EK L + S ++
Sbjct: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
Query: 3216 QQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQEAWATLQAKAQE 3270
Q+ R E +L+ + +V +LQ A +L G+ A +V + W L + ++
Sbjct: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
Query: 3271 RGQWLAQAAQGHAFLGRCQELLAW 3294
++ A F + ++LL+W
Sbjct: 610 ARLHVSSTADALRFHSQVRDLLSW 633
Score = 150 bits (379), Expect = 2e-35
Identities = 138/638 (21%), Positives = 282/638 (44%), Gaps = 22/638 (3%)
Query: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMA 2210
K L+HQAF AE+ ++E + + ++G+ L+ + A V ++L +R+ W +L
Sbjct: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76
Query: 2211 LRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSA 2270
+ ++L + + +Q + + E ++ D G DL ++L+
Sbjct: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM----- 131
Query: 2271 GDTVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGA 2328
++ + R + +L Q +P +++ +R++ + R L ++ L +
Sbjct: 132 -ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLAS 190
Query: 2329 LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
E+H ++ +LD+ +QE+ L + G L++VQ+ ++K++ L RE+ ++E +
Sbjct: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
Query: 2389 EREVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
G L RSPE A +R +++ +W LR A++R++ LDA Q ++ + E+
Sbjct: 251 LERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
Query: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
M + + ++L++H + + ++++ +SI+ + LL GHP
Sbjct: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
Query: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
S I + + +++ +L+ +E ++ L+Q L V ++E W+ KE S
Sbjct: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
Query: 2568 GLWDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQA 2624
L + L + K E+ E AG +++A+ L + GH A +
Sbjct: 430 ELGQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 487
Query: 2625 MLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTA 2679
+ L GTR L R+L F D++E+ + EK L E +
Sbjct: 488 LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 547
Query: 2680 MLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQD 2739
+ L+ ++ L + + Q QE + + + G H +EAI R +E+ W EL
Sbjct: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLS 605
Query: 2740 NSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
+ + +ALR + +L +W++ I ++ A
Sbjct: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 643
Score = 130 bits (326), Expect = 3e-29
Identities = 147/636 (23%), Positives = 268/636 (42%), Gaps = 25/636 (3%)
Query: 2359 KDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWW 2418
+D + + +H+ E+ + +E +ERE +L Q PE A +R + E+ + W
Sbjct: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69
Query: 2419 QLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ 2478
+L S Q + L +A +L EL + +Q+ L++ Q
Sbjct: 70 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129
Query: 2479 ECKAELDSWTDSISLARSTGQ-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEH 2533
+++++ W R G+ Q TA P ++++ + + L L QE
Sbjct: 130 SMESQVEEW------YREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
Query: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQ 2593
+ L + EL ++ W+ + + L ++ + K++ L +++
Sbjct: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
Query: 2594 AGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAF 2652
++ + A L PEA+ A+ R L A R+A RR + L+ Q++ +
Sbjct: 244 GPRLEEVLERAGALASLRSPEAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302
Query: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQ 2710
D EV AWL E+ L+ + E QL K ++ Q E +++ +L R+ +
Sbjct: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCR 361
Query: 2711 RLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
LL+ GHP SE I R ++ L+ L++ +++ L++ +L R + ELE+W+
Sbjct: 362 ALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAE 421
Query: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDV 2829
EV +P +GQ V L E + R+ A + Q + GH A +
Sbjct: 422 KEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
Query: 2830 EEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQD 2885
E L + + L E + R L A L KFF DA E ++EK LP L +
Sbjct: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
Query: 2886 YGQSLSAV-RHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
S S++ R L+ +L+ +S L + V AG A +A+R Q++ +
Sbjct: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQ 598
Query: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWL 2980
L + RL + +A +F +++ + SW+
Sbjct: 599 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634
Score = 125 bits (314), Expect = 8e-28
Identities = 142/647 (21%), Positives = 264/647 (40%), Gaps = 31/647 (4%)
Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQ 1258
D ED + +H+ F L+ E + G++L+Q + A +VR++L I+
Sbjct: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65
Query: 1259 AQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-MQWMEEKGLMAAHEPSGARRNILQTL 1317
W L+ ++ + RQL + + + Q AEL + + + + +P G + L
Sbjct: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125
Query: 1318 KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERG 1377
K+ ++ ES++ R V L Q L P +E + R + + L + ER
Sbjct: 126 KKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184
Query: 1378 DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLA 1437
L + + Q+ L D +++ +E G L++ Q+ K++Q L E +
Sbjct: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
Query: 1438 AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA-------IRGLQLQASVELHQF 1490
++ + A +A+ + E + R LE LQ A R L A+ ++ Q+
Sbjct: 245 PRLEEVLERAGALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302
Query: 1491 CHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRS 1550
+W+ E + L +KH +L+ V+ ++ + ++ R+
Sbjct: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRA 362
Query: 1551 LAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEK 1610
L GHP ++ I + +++ + L+ E R L+Q Q VSELE W+ EK
Sbjct: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
Query: 1611 RPLVSSRDYGRDEAATLRLINKH--------QALQEELAIYWSSMEELDQTAQTLTGPEV 1662
+ S + G+D L K A +E LA ++EL + T
Sbjct: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA--- 479
Query: 1663 PEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
++ L E L EL TR + L + LH+F +A +LQG + +++
Sbjct: 480 --TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
Query: 1723 SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE-RGHSAG---PMVRQRQQ 1778
+ E A + F+H +++ V+ R L E + R AG + R+Q
Sbjct: 538 TPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQ 594
Query: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
++ W EL + + T LR H + ++L+ + A+ +
Sbjct: 595 EVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQI 641
Score = 123 bits (309), Expect = 3e-27
Identities = 133/597 (22%), Positives = 248/597 (41%), Gaps = 40/597 (6%)
Query: 899 LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958
L+++ F+ LA K ++ +QL Q P + ++++ E+ Q W +LE+ + KA
Sbjct: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
Query: 959 VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018
QL + + +Q +L + QL+ + PG T ++ ++
Sbjct: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS-------------QLK 126
Query: 1019 FLQSVVVKVEEPGYAESQPLQGQVETL------QGLLKQVQEQVAQRARRQAET-QARQS 1071
LQS+ +VEE Y E LQ Q L + L+ + Q V +R R E Q R+
Sbjct: 127 KLQSMESQVEE-WYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 185
Query: 1072 FLQESQQL----------LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQE 1121
L S++L L W + E + + Q+ ++++Q L EI
Sbjct: 186 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 245
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGRE 1181
RL+++ ++ +A+L P+++ V L L L+ E+RQQ L +++++ +
Sbjct: 246 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 305
Query: 1182 VDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ 1241
V A + + ++ G+D + L LL++H + + + L L++
Sbjct: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 365
Query: 1242 SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLM 1301
HP + + + + + L+ E+RR L L + + V+EL W+ EK ++
Sbjct: 366 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
Query: 1302 AAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRL 1359
A G + L K E A +A R + A+ Q+ EL+ CG T
Sbjct: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIE---CGHTAAATMA 482
Query: 1360 Q---GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDL 1416
+ GL W L M R L + + + ++ + Q+E+ L T +
Sbjct: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEP 542
Query: 1417 R-SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQG 1472
R S+ +Q+ + E + + L +++ L A + A R E+LQG
Sbjct: 543 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
Score = 122 bits (307), Expect = 5e-27
Identities = 145/688 (21%), Positives = 264/688 (38%), Gaps = 85/688 (12%)
Query: 458 LRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEEL 517
L QE+ A V ++ E+ W L Q + +Q+ + L+Q +L +
Sbjct: 46 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 105
Query: 518 QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA 577
+ + G LA V L++ +E+QV V L QTA L S E++
Sbjct: 106 ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGE 164
Query: 578 KARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLS 637
+ + + L+ ++ RR LL + + + + ++E AW++E G L
Sbjct: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
Query: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQT 697
+ ++K++ L E+ H +++ R L++ R P E +Q W L+
Sbjct: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
Query: 698 RVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLER 757
R L A V QY+ D AE +WL E+ + G+D+ + LL++H++LE+
Sbjct: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
Query: 758 VLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKM 817
+ + + +L Q RA HP
Sbjct: 345 GVENYEESIAQLSRQCRALLEMG---------------------------HP-------- 369
Query: 818 ALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL 877
D I + Q + + Y +L+ L + RR LE+ L+ EL+ W+
Sbjct: 370 ----------DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
Query: 878 EKQTVLL--QRVQPQADTLEVMQLKYENFLTALAV-GKGLWAEVSSSAEQLRQRYPGNST 934
++ V+ + + + V+Q K+ F + + G+ A V+ ++L + +
Sbjct: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
Query: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL-QP 993
+ ++ L++ W +L L +A LA S E+ F + Q Q+ + +L L P
Sbjct: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
Query: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQ 1053
+ ++Q L H LQ +V +V +Q+Q
Sbjct: 540 PEPRPSASSMQ------RTLRAFEHDLQLLVSQV----------------------RQLQ 571
Query: 1054 EQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLL 1113
E AQ A A +E + L W E + A ++ + V+S LR H +
Sbjct: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA---CEDARLHVSSTADALRFHSQVR 628
Query: 1114 EEIHLWQERLQQLDAQSQPMAALDCPDS 1141
+ + Q+ A +P CP S
Sbjct: 629 DLLSWMDGIASQIGAADKPR----CPSS 652
Score = 111 bits (278), Expect = 1e-23
Identities = 124/582 (21%), Positives = 245/582 (42%), Gaps = 29/582 (4%)
Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE---EMAWVQE 2876
REG L Q+ E A + ++ +R+ E + +A++ L AD+ A + +
Sbjct: 41 REGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDK 100
Query: 2877 KLPLAAAQ----DYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFA 2931
KL +Q D G L+ V ++ Q++ES++ + + + T ++ +
Sbjct: 101 KLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--S 158
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
V R + + + L RR LL ++E Q +L + +W+ ER + +
Sbjct: 159 KELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTE 218
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
G+ +A Q +++ + +R+++A PR+E + + A L S ++PE+ V L+ ++ A
Sbjct: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSA 278
Query: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
A L AE R L Q+ Q + ++AWL + S+D G+D + L +K
Sbjct: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338
Query: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
+ V++ ++ R+ LE G P I ++S+++ + L + + R
Sbjct: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDS-EQISRRQSQVDRLYVALKELGEERRV 397
Query: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
L + ++ + +EL+ + EK + + G V LQ++ E +
Sbjct: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGR 457
Query: 3232 E-VARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWLAQAAQGHAFLG 3286
E +A + L + A +A+ + EAWA L R Q LA + + H F
Sbjct: 458 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
Query: 3287 RCQELLAWAQERQ----ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
+EL +E++ L + E + ++ L E +++ Q + L++
Sbjct: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFE---HDLQLLVSQVRQLQEGA 574
Query: 3343 QQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAES 3384
QL + E + + R QE+ + W C ++
Sbjct: 575 AQL------RTVYAGEHAEAIASREQEVLQGWKELLSACEDA 610
Score = 100 bits (250), Expect = 2e-20
Identities = 146/627 (23%), Positives = 264/627 (42%), Gaps = 35/627 (5%)
Query: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---RD 1688
+HQA ELA +E++++ Q L E PE V+++L E + EL +T +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
Query: 1689 RELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMG 1748
R+L + + ++ +L L + + + G D K + QVE
Sbjct: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEW 138
Query: 1749 SQRVAACRLLAESL-LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
+ V + +L LE ++ +V +RQ + L E Q R L ++ +V
Sbjct: 139 YREVGELQAQTAALPLEP--ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
Query: 1808 HRDLLEVLTQVQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
DL + L VQE+ ++ L ++ ++ +QGL RE+ +L+E+LE AG
Sbjct: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA 256
Query: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
+ L P+A AV++ + + AWA L+ E+R+ L+ A + ++ V + +W
Sbjct: 257 LASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315
Query: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQ--ALLAAGTPTKE 1984
+ E+ ++ S L H L +E E + QL +Q ALL G P
Sbjct: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD-- 370
Query: 1985 VQEELRALQDQRDQVYQTWAR--KQERLQAEQQEQLF--LRECGRLEEILAAQEVSLKTS 2040
E++ Q Q D++Y ++ R+ EQQ L+ R+ LE +A +EV +
Sbjct: 371 -SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
Query: 2041 ALGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTL------RRPRVRDRLPILL 2093
LG E V L K F + A ++ AA+ + + L + + L
Sbjct: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
Query: 2094 QRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
+ + EL +R L AS + F A + + I+ ++L P + R +
Sbjct: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
Query: 2154 LKH-QAFEAEVQ---AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM 2209
+ +AFE ++Q + + A + + A H A ++ R Q + + W++L A
Sbjct: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA--IASREQEVLQGWKELLSAC 607
Query: 2210 ALRGQELEDRRNFLEFLQRVDLAEAWI 2236
+ + L F +V +W+
Sbjct: 608 EDARLHVSSTADALRFHSQVRDLLSWM 634
Score = 98.6 bits (244), Expect = 1e-19
Identities = 144/651 (22%), Positives = 254/651 (39%), Gaps = 91/651 (13%)
Query: 358 LAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH---KAALRESFLKDAEQVL 414
L E+ QCWA LE + +QA ++L + + + L + F K ES L+D +
Sbjct: 61 LGEIRQCWAELE----STTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD--- 113
Query: 415 DQARAPPASLATVEAAVQRLGMLEAGI---LPQEGRFQALAEIADILRQEQYHSWADVAR 471
P LATV + +++L +E+ + + G QA + + S V
Sbjct: 114 -----PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL----EPASKELVGE 164
Query: 472 RQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLA 531
RQ V R RLL+ LQ +R+ + + + + +++ ++E A T G L
Sbjct: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
Query: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVA 591
V + ++++ L ++ AHG + + ++ L S E ++ R L QLQ +
Sbjct: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR---RGLEQLQSAWAG 281
Query: 592 LVRA---RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKA 648
L A R+ +L+ Q ++ + E EAWL E + + G+D L+KH
Sbjct: 282 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
Query: 649 LEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQT 708
LE V ++ L R+ R L P R V + L+ R L+
Sbjct: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
Query: 709 ALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVR-LERVLRAFAAELR 767
+ Q +E W+ E+ GQD HV L+ FA+E
Sbjct: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD--------FEHVSVLQEKFSEFASE-- 451
Query: 768 RLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDF 827
+ R L VN + + L G + A
Sbjct: 452 ------TGMAGRERLAAVNQMV----DELIECGHTAAA---------------------- 479
Query: 828 DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRV 887
T+ + +D L++ + L L R L + L F S ELQ +E++ L R+
Sbjct: 480 ---TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536
Query: 888 ------QPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-IQRQQ 940
+P A +++ +E+ L L ++ A QLR Y G + I ++
Sbjct: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLV---SQVRQLQEGAAQLRTVYAGEHAEAIASRE 593
Query: 941 EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL 991
+E+ Q W +L + + + ++ + + F Q+RD+L ++ +
Sbjct: 594 QEVLQGWKELLSACEDARLHVSSTADALRF-------HSQVRDLLSWMDGI 637
Score = 98.2 bits (243), Expect = 1e-19
Identities = 101/450 (22%), Positives = 191/450 (42%), Gaps = 8/450 (1%)
Query: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
R +A +L +E++++ L K + V +L +R+ AEL +A+
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
L E + QL + LD L + + D G DL V +K + +V+ +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
+V L+ L P + +++ + RL + ++ R L A+ E+H
Sbjct: 141 -EVGELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198
Query: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLG 3244
+ +QE+ L + G+ L +V+ ++++ L RE++A + + A L
Sbjct: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
Query: 3245 QLHP----AAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
L A GL ++Q AWA L+ A+ R Q L A Q + E+ AW E++
Sbjct: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318
Query: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
L SE+ +D QLL +H +L Q + L ++ + L++ H S +++
Sbjct: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378
Query: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
+++ L+E R + + L +L +++ + E W+A E + P+ G V
Sbjct: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438
Query: 3421 ELLLHRHQDL--EKLLAAQEEKFAQMQKTE 3448
+L + + E +A +E A Q +
Sbjct: 439 SVLQEKFSEFASETGMAGRERLAAVNQMVD 468
Score = 86.7 bits (213), Expect = 4e-16
Identities = 134/655 (20%), Positives = 267/655 (40%), Gaps = 46/655 (7%)
Query: 2055 KHEVFLKVLTAQDKK--EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRG 2107
+H+ F+ L AQ+K+ E RE + ++ VR +L + Q ++ +++
Sbjct: 21 RHQAFMAEL-AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
Query: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHE 2167
L + Q+ + + + QL++ P GDL L K Q+ E++V+
Sbjct: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
Query: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL---- 2223
+ + + AL + S+ L G R++ R L + L++RR L
Sbjct: 140 REVGELQAQTAALPLEP------ASKELVGERQNAVGERLVRLL--EPLQERRRLLLASK 191
Query: 2224 ---EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
+ +D AW+QE+ + G L+ +++ +++ +G +
Sbjct: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ---AVQQHIKKNQGLRREIQAHGPRLE 248
Query: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
+ + + L + E + + + QL + WA R QQ L+ A ++ ++
Sbjct: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308
Query: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
V + E+E L+ + D GKD +S +LL+KH +LE+ V + + L R+ L +
Sbjct: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368
Query: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL--LVSAQRLRAQM 2458
+ + RQ +V + L+ ++RR AL+ + +L + EL ++ + + A
Sbjct: 369 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA-- 426
Query: 2459 DTSPAPRSPVEARRMLEE-HQECKAELD-SWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
SP E +L+E E +E + + ++ +L+ GH ++ + +
Sbjct: 427 -GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
Query: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPM 2576
GL + + L L + EL F S +++ + K L L P P
Sbjct: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR--LTTPPEPR 543
Query: 2577 EPLLWKHKML---EWDLEVQAGKISALE---ATARGLHQGGHPEAQSALGRCQAMLLRKE 2630
+ L E DL++ ++ L+ A R ++ G H EA ++ R Q +L +
Sbjct: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS--REQEVLQGWK 601
Query: 2631 ALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
L R + F +++ +W+ + +A + G D P+ L
Sbjct: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWM---DGIASQIGAADKPRCPSSL 653
Score = 59.3 bits (142), Expect = 7e-08
Identities = 121/605 (20%), Positives = 233/605 (38%), Gaps = 77/605 (12%)
Query: 550 HGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-- 607
H A ++ LAQ L+ +++Q K A +++ L +R A LE T Q
Sbjct: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL-GEIRQCWAELESTTQAKAR 80
Query: 608 ---------EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
+ +++ E + L ++ + G DL+ + L+K +++E++V
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 659 VCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
+L + L P ++ GER AV L + R L + + Q D
Sbjct: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
Query: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
+ +W++ER + G A + ++++ L R ++A RLEE A A
Sbjct: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP---RLEEVLERAGA 256
Query: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
ASL SP E++R + +
Sbjct: 257 LASL------RSPEAEAVR------------------------------------RGLEQ 274
Query: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQ 898
L + LR A+ R+ L+ A + + E++ WL +Q +L+ D +Q
Sbjct: 275 LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334
Query: 899 L--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
L K+ + + A++S L + +S QI R+Q ++ + + L+ L E
Sbjct: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
Query: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------ 1010
+ V L + ++ + + + ++ A P +D H L +K +
Sbjct: 395 RRVALEQQYWLYQLSRQVSELEHWIAE--KEVVAGSPELGQDFEHVSVLQEKFSEFASET 452
Query: 1011 -LVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR 1069
+ R+ + +V ++ E G+ + + + L ++ E + RA+ A ++
Sbjct: 453 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512
Query: 1070 QSFLQESQQLLLWAESVQAQL----RSKEVSVDVASAQRLLR--EH--QDLLEEIHLWQE 1121
F ++++L E + +L E +S QR LR EH Q L+ ++ QE
Sbjct: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572
Query: 1122 RLQQL 1126
QL
Sbjct: 573 GAAQL 577
Score = 58.2 bits (139), Expect = 1e-07
Identities = 106/492 (21%), Positives = 192/492 (39%), Gaps = 46/492 (9%)
Query: 255 VQRRLTKILLQLQETE---LLQTQYEQLVADL---LRWIAEKQMQLEARDFPDSLPAMRQ 308
V RL ++L LQE L + Q+ DL L W+ E+ + + L A++Q
Sbjct: 169 VGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
Query: 309 LLAAFTIFRT--QEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366
+ R Q PRL++ L L++ RR GL +L WA
Sbjct: 229 HIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSAWA 280
Query: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPAS 423
GL A R Q L ++ A E++L + E ++ D+ + ++
Sbjct: 281 GLREAAERRQQVLDAAF--------QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQST 332
Query: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
L ++ +Q LE G+ E L+ L + + ++RRQ +V R
Sbjct: 333 LQLLKKHLQ----LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVD-RLYVA 387
Query: 484 LQHLQGQRKQVADMQAVL-SLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDL 542
L+ L +R+ + Q L L ++V H + E + A S GQ V L ++
Sbjct: 388 LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSE 447
Query: 543 LEAQVSAHG-AHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLE 601
++ G ++ + Q EL T+ + L + L+ L+ R LL
Sbjct: 448 FASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLA 507
Query: 602 QTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661
+ + +F + E + ++E +R+ + A ++Q + L A H Q + V
Sbjct: 508 ASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ--RTLRAFEHDLQ-LLV 564
Query: 662 DLVRRGRDLSARRPPTQPDPGERAEAVQG-------GWQLLQTRVVGRGARLQTALLVLQ 714
VR+ ++ +A+ GE AEA+ GW+ L + + + L+
Sbjct: 565 SQVRQLQEGAAQLRTVY--AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
Query: 715 YFADAAEAASWL 726
+ + + SW+
Sbjct: 623 FHSQVRDLLSWM 634
Score = 52.0 bits (123), Expect = 1e-05
Identities = 132/674 (19%), Positives = 236/674 (35%), Gaps = 81/674 (12%)
Query: 645 KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGA 704
+H+A AE+ +++ + R G+ L +P ++ ++ W L++ +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 705 RLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAA 764
+L A Q AE L S L+ G D A + L++ +E + +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 765 ELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPD 824
E+ L+ Q ALP EP
Sbjct: 141 EVGELQAQ-------------------------------------------TAALPLEP- 156
Query: 825 PDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL 884
+ + Q+ + + L Q RR L + L + W++++ L
Sbjct: 157 --ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLA 214
Query: 885 QRVQPQADTLEVMQ---LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQE 941
+ + + + L+ +Q K + + EV A L + ++R E
Sbjct: 215 MQTE-RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLE 273
Query: 942 ELSQRWGQLE--ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDT 999
+L W L A +R++ + A VE F + + L + L + + G E +
Sbjct: 274 QLQSAWAGLREAAERRQQVLDAAFQVEQYYF--DVAEVEAWLGEQELLMMSEDKGKDEQS 331
Query: 1000 CHALQLAQKKTLVLERRVHFLQSVVVKVE-------EPGYAESQPL---QGQVETLQGLL 1049
LQL KK L LE+ V + + ++ E G+ +S+ + Q QV+ L L
Sbjct: 332 --TLQLL-KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388
Query: 1050 KQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREH 1109
K++ E+ +R + + Q Q S +L W + S E+ D L +
Sbjct: 389 KELGEE--RRVALEQQYWLYQLSRQVS-ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 445
Query: 1110 QDLLEEIHL-WQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQW 1168
+ E + +ERL ++ + + + L + EL L R Q
Sbjct: 446 SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 505
Query: 1169 LQEGLELQKF---GREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTL 1225
L EL KF RE+ G + L E A S+ + R F L L
Sbjct: 506 LAASRELHKFFSDARELQGQIE--EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLL 563
Query: 1226 GPRAEALRAHGEKL---VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQ 1282
+ L+ +L +H A RE Q + W L E R + ++
Sbjct: 564 VSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQGWKELLSACEDARLHVSSTADAL 621
Query: 1283 EWKQDVAELMQWME 1296
+ V +L+ WM+
Sbjct: 622 RFHSQVRDLLSWMD 635
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 254 bits (648), Expect = 1e-66
Identities = 313/1256 (24%), Positives = 509/1256 (40%), Gaps = 163/1256 (12%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KT TKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 175 RVQKKTSTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 231
Query: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 232 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 291
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 292 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 347 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 406
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 407 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 459 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 514
Query: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 515 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQS----DIRLLAAGKVPQRAGE 570
Query: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 571 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 630
Query: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 631 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 689
Query: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 690 SHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 749
Query: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 750 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 809
Query: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 810 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 869
Query: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 870 QLQKLQEALRRKNSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 921
Query: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
L P P +R P + + GD ++ PA+P
Sbjct: 922 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 981
Query: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 982 AAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1041
Query: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 1042 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1098
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 1099 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1133
Query: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
T H L+L K E +R+ Q +VE EP A
Sbjct: 1134 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1192
Query: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1193 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1252
Query: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1253 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1312
Query: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+
Sbjct: 1313 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
Score = 73.6 bits (179), Expect = 3e-12
Identities = 188/885 (21%), Positives = 331/885 (37%), Gaps = 136/885 (15%)
Query: 1455 AILEETQKHLR----RLELLQGHLAIRGLQLQASV---ELHQFCHLSNMELSWVAEHMPH 1507
AILE +K LR RLE LQ + LQ++A + +LHQ L ++ +A
Sbjct: 509 AILER-EKQLRSEFERLECLQR--IVTKLQMEAGLCEEQLHQADALLQSDIRLLA----- 560
Query: 1508 GSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQ 1567
A + ++ E++ ++ ++ + + ++L HPQ + + +
Sbjct: 561 ------------AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY 608
Query: 1568 ELEGHWAELERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEK 1610
L + R AQ Q+V + D + +L WVEE
Sbjct: 609 RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN 668
Query: 1611 RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ 1670
+ V ++G D + + H+ L + + + + +E L+ P R
Sbjct: 669 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS-PATRGAYRDCL 727
Query: 1671 ERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEH 1730
RL Q L + R R LE LH F+ A WL ++K+ + G + +
Sbjct: 728 GRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTN 783
Query: 1731 ALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWEL 1790
++ ++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 784 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 843
Query: 1791 TQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD----LCGLEAQLRSHQGL 1846
L++ + D+ E Q+Q+ +L + D + LE L+ Q
Sbjct: 844 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDE 903
Query: 1847 ERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR----------QQAVT--------- 1887
+ +L + L L + A V +L P AH ++ R Q VT
Sbjct: 904 KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 963
Query: 1888 ------QAWAVL-------------------QRRMEQRRAQLER-----ARLLARFRTAV 1917
W VL + +++ +LE L + +
Sbjct: 964 VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDM 1023
Query: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLW----QQATQLGQQ 1973
+ +W + +R+D+Q+ S + LK + LE + + Q A G +
Sbjct: 1024 KSLLAWQS-LRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 1082
Query: 1974 ALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLREC-----GRLEE 2028
L A + L +Q Q +R Q + + +L L C RL
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1142
Query: 2029 IL---AAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
L A+E + + + + EVE L + + L+A+ +K AL E + P +
Sbjct: 1143 PLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEAEKVLALPE--PSPAAPTL 1196
Query: 2086 RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPG 2144
R L + L + +V+ L+ L L+ TQ AE+ ++A +QLKE P
Sbjct: 1197 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG---AEEVLRAHEEQLKEAQAVPA 1253
Query: 2145 DL--RDKLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAGEVS---QR 2194
L + K LK +AE Q A + + + GE L + R EV +R
Sbjct: 1254 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1313
Query: 2195 LQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQE 2238
+ L + W+ + +R +ELE R + + D AW+Q+
Sbjct: 1314 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
Score = 63.5 bits (153), Expect = 4e-09
Identities = 101/434 (23%), Positives = 169/434 (38%), Gaps = 33/434 (7%)
Query: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQR 1271
L +E+G+L + R + LR+ E+L E LQ I + G E++
Sbjct: 497 LDVEKEWGKLHVAILEREKQLRSEFERL------------ECLQRIVTKLQMEAGLCEEQ 544
Query: 1272 RRQLLASLQLQEWKQDVAELMQWMEE--KGLMAAHEPSGARRNILQTLK--RHEAAESEL 1327
Q A LQ ++ Q E + L A N +QTLK RH E
Sbjct: 545 LHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMY 604
Query: 1328 LATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387
R E L + E R G T++ + + +R EL+ +
Sbjct: 605 RRVYRLHERLVAIRTEYNLRLKAGVAAPATQVA-------QVTLQSVQRRPELE-----D 652
Query: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447
LR LQD +E+ + + +E G DL S + H+ L AK+ S
Sbjct: 653 STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDE 712
Query: 1448 HGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLSNMELSWVAEHMP 1506
+ SPA + L RL+L L S+E LH F + EL W+ E
Sbjct: 713 GQL--SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
Query: 1507 HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQC 1566
+++ + + L E++ + +++ + ++G L HP A+ VE
Sbjct: 771 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP-ARPTVESF 829
Query: 1567 QE-LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAA 1625
Q L+ W+ + + C L++ + Q+F DV E EG +++ + + ++ A
Sbjct: 830 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889
Query: 1626 TLRLINKHQALQEE 1639
RL + Q Q+E
Sbjct: 890 VTRLEDLLQDAQDE 903
Score = 60.8 bits (146), Expect = 2e-08
Identities = 215/1011 (21%), Positives = 362/1011 (35%), Gaps = 206/1011 (20%)
Query: 463 YHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQ-EVEAASHQLEE----L 517
YH DV + ++ V + L+ + +++ +Q +++ LQ E QL + L
Sbjct: 494 YHP-LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL 552
Query: 518 QEPARSTACG---QQLAEVVELLQRHDLL------EAQVSAHGAH---------VSHLAQ 559
Q R A G Q+ EV L + D + + Q G H V L +
Sbjct: 553 QSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 612
Query: 560 QTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAW 619
+ + + ++ A T Q+ Q + V+ R L + TL R ++ AW
Sbjct: 613 RLVAIRTEYNLRLKAGVAAPAT--QVAQVTLQSVQRRPELEDSTL------RYLQDLLAW 664
Query: 620 LKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQP 679
++E RV A G DL + L H+ L + QA + R R
Sbjct: 665 VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAK----IERARS---------- 710
Query: 680 DPGERAEAVQGGWQ-------LLQTRVVGRG-ARLQTALLVLQYFADAAEAASWLRERRS 731
D G+ + A +G ++ L +++ ARL++ + + A A + WL E+
Sbjct: 711 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK-- 768
Query: 732 SLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791
E G D + R+ + +++A +R LE + +
Sbjct: 769 --EEEEVGFDWSD------RNTNMTAKKESYSALMRELELKEKKI--------------- 805
Query: 792 PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851
+ L+N G HP A P T+ Q L + + L
Sbjct: 806 --KELQNAGDRLLREDHP-----------ARP-------TVESFQAALQTQWSWMLQLCC 845
Query: 852 LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911
A L+E A F F S E + L+K L+R + V +L
Sbjct: 846 CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRL------------ 893
Query: 912 KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL-KREKAV-QL-----AHS 964
E L Q Q ++E+L++ G L L KR KAV QL AH
Sbjct: 894 -----------EDLLQ-------DAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 935
Query: 965 VEV-CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSV 1023
+ L C QV++ + G Q + K L + SV
Sbjct: 936 MRGRLPLLAVCDYKQVEV--------TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV 987
Query: 1024 VVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ-RARRQAETQARQSFLQESQQLLLW 1082
V P ++VQE V + A+ QA + + LL W
Sbjct: 988 CFLVPPPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1029
Query: 1083 AESVQAQLRSKEV--SVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140
Q+ R ++ S +A+ + L E Q + +H + Q SQ D
Sbjct: 1030 ----QSLRRDVQLIRSWSLATFRTLKPEEQR--QALHSLELHYQAFLRDSQDAGGFGPED 1083
Query: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA------TCANHQA 1194
R G + L + +Q QE Q+ E+ T H+
Sbjct: 1084 RLMAE---REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140
Query: 1195 WLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVRE 1252
L LD E RE + + ++ + LG L A EK++ PAA T+R
Sbjct: 1141 RLPLDK--EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198
Query: 1253 QLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS----- 1307
+L+ + +++ S +L + Q E+++ EE+ A P+
Sbjct: 1199 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1258
Query: 1308 -GARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-----RLQG 1361
+ ++ + + EA + A R + Q+VG L R G+ D++ R+
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH--GERDVEVERWRERVAQ 1316
Query: 1362 LRSKWEALNRKMTERGDELQQAGQQEQLLRQ--------LQDAKEQLEQLE 1404
L +W+A+ + R EL+Q G+Q + R+ LQDA+ + EQ++
Sbjct: 1317 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
Score = 57.0 bits (136), Expect = 3e-07
Identities = 93/430 (21%), Positives = 164/430 (38%), Gaps = 48/430 (11%)
Query: 2938 RVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAE 2997
R++ L++ + L+ EA L QA Q LL AG G V D+ +
Sbjct: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEV--ERDLDKADS 580
Query: 2998 ATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLR 3057
+ L ++ K + P+ E++ + L R L A+R + L+
Sbjct: 581 MIRLLFNDVQTLK---DGRHPQGEQMYRRVYRLHER-----------LVAIRTEYNLRLK 626
Query: 3058 RAEARGHGLQEQLQLHQLERETLLLD----------AWLTTKAATAESQDYGQDLEGVKV 3107
A Q+ L ++R L D AW+ + ++G DL V+
Sbjct: 627 AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 686
Query: 3108 LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIK 3167
+ ++ QAK+ R G L Y R++ + +L + K
Sbjct: 687 QLGSHRGLHQSIEEF-QAKIERARSDEGQLSPATRGAYRDCLG---RLDLQYAKLLNSSK 742
Query: 3168 ARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELE 3227
AR +L + +HSF AA + + EK G D +++ ++ + L RELE
Sbjct: 743 ARLRSLES---LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 799
Query: 3228 AMEKEVARLQTEACR-LGQLHPAAP---GGLAKVQEAWA-------TLQAKAQERGQWLA 3276
EK++ LQ R L + HPA P A +Q W+ ++A +E +
Sbjct: 800 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 859
Query: 3277 QAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQ 3336
+ G+ Q+L QE +S + + V E LL ++ +++ E +
Sbjct: 860 FFSDVREAEGQLQKL----QEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 915
Query: 3337 DLRQEGQQLV 3346
L + + +V
Sbjct: 916 GLAKRAKAVV 925
Score = 55.1 bits (131), Expect = 1e-06
Identities = 155/748 (20%), Positives = 282/748 (37%), Gaps = 118/748 (15%)
Query: 2212 RGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ-------LRRRLRE 2264
R ELED + L +LQ DL AW++E + +++ + G DL L + + E
Sbjct: 646 RRPELED--STLRYLQ--DLL-AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEE 700
Query: 2265 F-----RGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
F R S + A + D L D + K++ +++L + S H +
Sbjct: 701 FQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSL-ESLHSFVA 756
Query: 2320 RYQQQLEGALEIHVLSRELD------NVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
++L E D N+T + + AL++ L+ + + ++ L +
Sbjct: 757 AATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE--KKIKELQNAGDR 814
Query: 2374 LEREVHPIQAQVESLEREVG-------RLC-----QRSPEAAHGLRHRQQEVAESWWQLR 2421
L RE HP + VES + + +LC AA+ AE Q
Sbjct: 815 LLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL 874
Query: 2422 SRAQKRREALDALHQAQKLQAMLQELLVSAQRL------------RAQMDTSPAPRSPVE 2469
A +R+ + D +L+ +LQ+ ++L RA+ PR P
Sbjct: 875 QEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934
Query: 2470 ARR----------------MLEEHQECKAELDSWTDSISLARSTGQQLLTAG-----HPF 2508
R + + EC+ + + S+G + P
Sbjct: 935 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994
Query: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
+ ++++ + LE + +L W + + ++ L Q V+ + W SLA+
Sbjct: 995 NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW------SLAT-- 1046
Query: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPE----AQSALGRC-- 2622
+ L P E H + +L QA + +A G PE A+ G C
Sbjct: 1047 -FRTLKPEEQRQALHSL---ELHYQAFLRDSQDAGGFG------PEDRLMAEREYGSCSH 1096
Query: 2623 --QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAM 2680
Q +L E ++ + + EL+ ++ L+ A R + + L
Sbjct: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE-----ACETRTVHRLRLPLDKEPARE 1151
Query: 2681 LPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDN 2740
++ +QQ QAE++ L E +++L P+ A R EL G+L+
Sbjct: 1152 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR-SELELTLGKLEQV 1210
Query: 2741 SQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR-APTVGQALPGVGELLGTQRELEA 2799
L+K + R + E L E +L+ A V LP + + ++L A
Sbjct: 1211 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1270
Query: 2800 AVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE-----EQARRLLQRFKSLREPLQE 2849
+ + +AL + + G L Q DVE E+ +LL+R++++
Sbjct: 1271 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1330
Query: 2850 RRTALEARSLLLKFFRD-ADEEMAWVQE 2876
R+ LE L+++R+ AD AW+Q+
Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQD 1358
Score = 52.8 bits (125), Expect = 6e-06
Identities = 185/890 (20%), Positives = 328/890 (36%), Gaps = 141/890 (15%)
Query: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 477 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 531
Query: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
+L + A Q+ + A + A ++ + E + +LD I L + Q
Sbjct: 532 TKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 591
Query: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 592 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 648
Query: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 649 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 701
Query: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
P + A C L + A + + + RL L L +F+ +
Sbjct: 702 QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 759
Query: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 760 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
Query: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 820 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
Query: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 880 RKNSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934
Query: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
+ G Q + V +G C L + ++L S
Sbjct: 935 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994
Query: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
+ +QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 995 NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1054
Query: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 1055 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1114
Query: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 1115 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1170
Query: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 1171 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1230
Query: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1287
Query: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
+++ L++ R ++ R R+ ER QA+ A+T+
Sbjct: 1288 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTD 1329
Score = 52.0 bits (123), Expect = 1e-05
Identities = 69/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
Query: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 471 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 526
Query: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 527 LQRIVTKLQMEAGLCEEQLHQADALLQSDI---RLLAAGKVPQRAGEVERDLDKADSMIR 583
Query: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
L + L HP +V A + A A + Q Q+
Sbjct: 584 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 643
Query: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Q + L Q+LLAW +E Q E D+ E LG H L Q I E +
Sbjct: 644 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQA 703
Query: 3334 QAQDLRQEGQQL 3345
+ + R + QL
Sbjct: 704 KIERARSDEGQL 715
Score = 51.6 bits (122), Expect = 1e-05
Identities = 148/781 (18%), Positives = 297/781 (38%), Gaps = 105/781 (13%)
Query: 1802 ETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
++TLR +DLL + + Q + V DL +EAQL SH+GL + + + +++
Sbjct: 652 DSTLRYLQDLLAWVEENQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFQAKIERAR 709
Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYA 1921
G++ G + + + + +A+L L F A
Sbjct: 710 SDEGQLSPATRGAYRDCLGRLDLQYAKL-------LNSSKARLRSLESLHSFVAAATKEL 762
Query: 1922 SWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTP 1981
W ++ + S ++ K ++ L ELE +EK ++ G + L
Sbjct: 763 MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPA 822
Query: 1982 TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK--- 2038
V+ ALQ Q + Q + L+ F + E L + +L+
Sbjct: 823 RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKN 882
Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL--RRPR-----VRDRLPI 2091
+ ++V +E L++ + + L + L +R K + +PR +R RLP+
Sbjct: 883 SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPL 942
Query: 2092 LLQRRMRVKELAESRG---------HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142
L + E+ +G H +L +S ++AA + ++ VP
Sbjct: 943 LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFL----------VP 992
Query: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRL--QGLRK 2200
P + Q +E +T + + +AL+ H ++ L Q LR+
Sbjct: 993 PPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRR 1034
Query: 2201 HWEDLR--QAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVG---------DLG 2249
+ +R R + E++R L L+ +A++++ + G + G
Sbjct: 1035 DVQLIRSWSLATFRTLKPEEQRQALHSLEL--HYQAFLRDSQDAGGFGPEDRLMAEREYG 1092
Query: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309
H QL + L + + ++ CI + D+ LQL + E + + + R L+
Sbjct: 1093 SCSHHYQQLLQSLEQ---GAQEESRCQRCISELKDIRLQL---EACETRTVHRLRLPLDK 1146
Query: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369
A + QQ+ + E+ L + + ++ ++ AL + L S L
Sbjct: 1147 EPARECAQRIAEQQKAQA--EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1204
Query: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
E R + I +E L + + + + + A LR ++++ E+ +
Sbjct: 1205 GKLEQVRSLSAI--YLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEA------------Q 1249
Query: 2430 ALDA-LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE-----ARRMLEEHQECKAE 2483
A+ A L + + +A L++L A+ AQ T A R + R+ + H E E
Sbjct: 1250 AVPATLPELEATKASLKKLRAQAE---AQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1306
Query: 2484 LDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE--GAWQEHQLQLQQAL 2541
++ W + ++ Q +L ++ Q+ L S + GAW + + Q+ +
Sbjct: 1307 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1366
Query: 2542 E 2542
+
Sbjct: 1367 Q 1367
Score = 48.5 bits (114), Expect = 1e-04
Identities = 148/715 (20%), Positives = 277/715 (38%), Gaps = 80/715 (11%)
Query: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395
R L ++ ++E + + + G DL SV+ L H L + + QA++E + G+L
Sbjct: 656 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL 715
Query: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR 2455
SP R + + +L + ++ R +L++LH + A +EL+ ++
Sbjct: 716 ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSF--VAAATKELMWLNEKEE 770
Query: 2456 AQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
++ + R+ + E + EL+ I ++ G +LL HP +
Sbjct: 771 EEVGFDWSDRNTNMTAKK-ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 829
Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575
A L+ + S + + L++ F S V + E L +++L + D A
Sbjct: 830 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889
Query: 2576 ---MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKE 2630
+E LL + + L G +S L A+ + Q HP A GR + +
Sbjct: 890 VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCD- 947
Query: 2631 ALFRQAGTRRHRLEELRQLQ----------------------AFL-----QDSQEVAAWL 2663
++Q H+ +E + + FL Q+ QE L
Sbjct: 948 --YKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005
Query: 2664 REKN--LVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPAS 2720
++ LV L L +D L A +++ Q S+ + L+ E QR Q H
Sbjct: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR--QALHSLE 1063
Query: 2721 ---EAIQERLEELGAL-----------WGELQDNSQKKVAKLQK-ACEALRLRRSMEELE 2765
+A ++ G +G + Q+ + L++ A E R +R + EL+
Sbjct: 1064 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1123
Query: 2766 N---WLEPIEVE----LRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAF 2818
+ LE E LR P + + + Q++ +A V+ + L +A+
Sbjct: 1124 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1183
Query: 2819 VR--EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQE 2876
+ E A + + L + + +R L+ SL+++ + A+E + +E
Sbjct: 1184 LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1243
Query: 2877 KLPLAAAQDYG-QSLSAVR-HLQEQHQNLESEMSSHEALTRVVLGT---GYKLVQAGHFA 2931
+L A A L A + L++ E++ + +AL + G G +L Q
Sbjct: 1244 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1303
Query: 2932 AHEVAA---RVQQL-EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
EV RV QL E+ A L R+R L Q ++ + + G+WL +
Sbjct: 1304 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
Score = 42.0 bits (97), Expect = 0.011
Identities = 173/785 (22%), Positives = 292/785 (37%), Gaps = 107/785 (13%)
Query: 746 ETLLRRHVRLERVLRAFAAELRRLEEQGRAASA-RASLFTVNSALSPPG------ESLRN 798
E + RR RL L A E + G AA A + + T+ S P L++
Sbjct: 601 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660
Query: 799 PGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLE 858
W E + H G W + LP+ L + L Q E +A ++ RAR +
Sbjct: 661 LLAWVEENQHRVDGAEWGVDLPSV-------EAQLGSHRGLHQSIEEFQA--KIERARSD 711
Query: 859 EAM---ALFGFCSSC-GELQLWLEKQTVLLQRVQPQADTLEVM---------QLKYENFL 905
E A G C G L L K LL + + +LE + +L + N
Sbjct: 712 EGQLSPATRGAYRDCLGRLDLQYAK---LLNSSKARLRSLESLHSFVAAATKELMWLNEK 768
Query: 906 TALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE--------K 957
VG W++ +++ ++ Y +++ +++++ + + L RE +
Sbjct: 769 EEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVE 827
Query: 958 AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017
+ Q A + LQ C + L++ + D A QK L R+
Sbjct: 828 SFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-----DVREAEGQLQKLQEALRRKN 882
Query: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQ 1077
+S V E ++Q + Q+ +G L + A+RA+ + + R
Sbjct: 883 SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL----AKRAKAVVQLKPRHPAHPMRG 938
Query: 1078 QLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALD 1137
+L L A Q+ EV+V +L+ Q H +A + L
Sbjct: 939 RLPLLAVCDYKQV---EVTVHKGDECQLVGPAQPS----HWKVLSSSGSEAAVPSVCFLV 991
Query: 1138 CPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLH 1197
P +QEV + L Q Q L LW Q ++ L Q R+V + L
Sbjct: 992 PPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK 1051
Query: 1198 LDNLGEDVREALSLLQQHREF----GRLLSTLGP--RAEALRAHG------EKLVQSQHP 1245
E+ R+AL L+ H + + GP R A R +G ++L+QS
Sbjct: 1052 ----PEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1107
Query: 1246 AAHTVR------EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298
A +L+ I+ Q + R+ R R L +E Q +AE + E +
Sbjct: 1108 GAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVE 1167
Query: 1299 GL-MAAHEPSGARRNILQTLKRHEAA---ESELLATRRHVEALQQVGRELLSRRPCGQED 1354
GL S +L + AA SEL T +E ++ + L + +
Sbjct: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK----LKT 1223
Query: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414
I ++G + E L ++L++A L +L+ K L++L ++ +
Sbjct: 1224 ISLVIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1279
Query: 1415 D-----LRSSQ----RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465
D LR +Q RLQ+RH + + E ++A L + A+L +T R
Sbjct: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTDVRQR 1333
Query: 1466 RLELL 1470
LE L
Sbjct: 1334 ELEQL 1338
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 222 bits (566), Expect = 5e-57
Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)
Query: 408 KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
K+ ++ L++ +A +++ + AV++L +L+A +LP + Q + DI+ +
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2080
Query: 461 EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
+ S V R E++ + R L G + + M V S L+E + Q P
Sbjct: 2081 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2130
Query: 521 ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
STA + +++ ++ +LE ++ + ++ + ++ + ++++ ++ LQAK
Sbjct: 2131 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2183
Query: 580 RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
+ L+ + A +E+ + E N E+ + +L+ Q + + G+D++
Sbjct: 2184 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2243
Query: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
+++ +Q+ + E +H V L++ ++S+ P+ E+ + ++ ++
Sbjct: 2244 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2300
Query: 697 TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
+ + + + L F ++ SW++E + ++ Q AE L L
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2357
Query: 753 VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
+L+ E++++ G SL + SA++ P +++ S + G G
Sbjct: 2358 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2409
Query: 813 DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
A +F N +I + +S YE L L + + A L ++ L
Sbjct: 2410 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2462
Query: 868 SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
+ WL+K + Q P E ++ + E +F L E+
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2522
Query: 923 EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
+L + P + +Q E+ +W +L L ++ +L S + L + + Q
Sbjct: 2523 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2579
Query: 981 LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
L+ L++ E L P S + Q Q + L+ E Q + G S+
Sbjct: 2580 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2638
Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
P G+ +L+G++K+ V Q+ + R ++ ++ Q LL +
Sbjct: 2639 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2696
Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
L +K VS + + L Q + +EI +++++ A + ++AL +
Sbjct: 2697 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2756
Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
E+ L + + ++++ E Q LQ + Q+ R+ + T Q H
Sbjct: 2757 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2816
Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
+ DV E SL++ H++F + L+ E A GE L+ ++Q ++ QL +
Sbjct: 2817 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2874
Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
I+ W + ++R +L SL+ ++K+ V L W+++ + + +P+
Sbjct: 2875 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 2934
Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
+I + ++ + E+ VE L LLS +E + + L K + +
Sbjct: 2935 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2990
Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
+ MT++ E Q+ ++ + RQLQ AKEQL+ + + + + L Q
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3048
Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
QK Q L+ + ++ LA + AS + G S +L+ ET Q+H + +
Sbjct: 3049 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3106
Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
+ +LQ + + + + +P A++L +K KE +
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3157
Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
KA +++ +++S + + A+ + + +QC +L E
Sbjct: 3158 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3217
Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
E + L++ + +++ + + + E E + P+ + + ++ K +
Sbjct: 3218 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3277
Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
LQ ++ + W + L Q+A T + E + + + + L + A R +L E
Sbjct: 3278 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3333
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
L F E L W+ ++ + P A K K Q Q + QR+
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3385
Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
R +++R +A P + ++ L + W L + R L
Sbjct: 3386 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3445
Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
+ + LE L + EK + LE Q+ H+ LE +++ + L + +
Sbjct: 3446 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3505
Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
+ G+ K+ + + Q + +Q W + +Q + R L++A A+ F +
Sbjct: 3506 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3564
Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
+W V L + G K + + L+ ++ R++ QA G + L
Sbjct: 3565 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624
Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
G +Q++L A++ + + + + L+ Q L C L+ E
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684
Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
+L+ + LK + ++L ++ + +L + ++ +AL E + R +
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744
Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
+ +R V + + + A++L + F QAA WI ++L + GD+R
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3801
Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
D+ L+ Q F E+ H++++ + K G ++ A S + ++L + K++
Sbjct: 3802 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3861
Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
+ + Q + R +LE ++ + +F + + W+ E + + L Q E
Sbjct: 3862 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 3921
Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
QLR + E + + I ++ QL P E I ++ + ++
Sbjct: 3922 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3971
Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
++ + L+ A+ + +D + + ++ E L Q ++E ++ + ++
Sbjct: 3972 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031
Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
+ + ++ +Q E+L++ + RS +A ++ + ++ W + + ++
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4091
Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
R + LD + A+K L+V+ + + + D P ++ E + + E+
Sbjct: 4092 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4151
Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
D + + + + G +L+ A G P +++ + L SL AW++ +L++A++
Sbjct: 4152 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4211
Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
+ + ++ + W+ LAS + L ++ + + K + + Q ++ L
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271
Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
A L + E+ + M L+ ++L + R+H+LE L L F E
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331
Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
+ AWL + E+ + D + +L K Q ++ A + + + G L++
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391
Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
G AS +Q +LE L W + + ++++ +L A +A +E+L+ WL E
Sbjct: 4392 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450
Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
L A LP E L E+ AA + K ++L+ + Q + A+ ++++
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510
Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
L ++++S+ L ER+T LE A +L ++F + + W+ Q + L A
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570
Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
L V ++H+ +E++SH + TG L +F+ + ++ L
Sbjct: 4571 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4627
Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
EK + L R R L + A+QF + WL E LDSE ++ + + +
Sbjct: 4628 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4684
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
L + + ++ L A + +T L+ + + ++ K+ L +R+ + +
Sbjct: 4685 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744
Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+ R + L+E L + L L+D + AE Q D++ V L + AF+
Sbjct: 4745 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4804
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
KE+ + V AL++ A L G+ ++ Q + WE + ++ L AA
Sbjct: 4805 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4863
Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
VH+ + AE + ++ L ED ++RTL QH+ ++LE
Sbjct: 4864 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 4917
Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
E+ + T + L P + ++ ++A+ +E W Q A A
Sbjct: 4918 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4975
Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
L QEL L WA+ E + +++ + L+ +H+ +E+
Sbjct: 4976 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026
Score = 209 bits (531), Expect = 5e-53
Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKWIN + + +LY +L DG +L+ LLE++SG+ LP +GR+R H
Sbjct: 64 KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 120
Query: 79 FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +L R +V + I ++I DG+ L LGLIW IIL FQIS I + E
Sbjct: 121 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 180
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
SA KE LL+W Q+ T Y + +F+ W DG FNA+IH +RPDL+D ++
Sbjct: 181 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 235
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE ++G+ +LLDPEDV + PDE+S++TYVS Y ++ +G
Sbjct: 236 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 292
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
+ + E+ +Y+ +V L++WI + R FP++ ++ L + F+
Sbjct: 293 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 346
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
E PP+ ++ + L L+ ++ + +G ++ + W L A R +
Sbjct: 347 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 403
Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
AL+ + +L+ L+ +A R Q + + E L A L L
Sbjct: 404 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 447
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
E+G+ +FQ AEIA + + + RQ + V Q L+ Q Q+ +
Sbjct: 448 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 492
Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
Q V L E+ A ++ + R Q + + Q + AQ + H + S L
Sbjct: 493 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 551
Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
Q T L SS TS VE + L
Sbjct: 552 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 611
Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
Q+++ L+ + +LL+Q L E ++ ++ W+ E ++ G DL +
Sbjct: 612 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 666
Query: 643 LQKHKALEAEVHR 655
L+ HK VHR
Sbjct: 667 LENHK----NVHR 675
Score = 203 bits (516), Expect = 3e-51
Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)
Query: 872 ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
+ Q WL+ + + P + D LE + +++F L ++ + + E L +
Sbjct: 2800 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2859
Query: 929 YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
G+ +Q Q + W +E+ +L S+E +E T Q
Sbjct: 2860 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2919
Query: 980 QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
L ++ L P E++ L+ QK+ +L + L SV +E
Sbjct: 2920 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2976
Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
E++ L +V+ L+ + ++ +E +V++ ++RQ + Q + +S
Sbjct: 2977 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3036
Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
++ L++++ S+ L+ DL + + AQ + A D
Sbjct: 3037 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3079
Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
+ +V + + Q+ L +++ +L+ L+ + F + + A L
Sbjct: 3080 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3137
Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
D++ R+A +L +Q L L EAL A + + P
Sbjct: 3138 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3193
Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
++ L+++ Q +L R++ R Q+ +++ L+E+ + E L+Q EE +
Sbjct: 3194 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3251
Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
P G L K + E E L ++ + + +G+ L+ + + + ++ L
Sbjct: 3252 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3309
Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
+ ++W+ LN+K+ +R +LQ+A E LL + D +E + Q + +
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369
Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
++ + LQ+ +S + + +A+ A A IL++ R E L
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3428
Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
R QL+ + + H+ N L+ + + + + P T+ + + +
Sbjct: 3429 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3486
Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
HK L+ ++ H + + +S G+SL + + +V+ + W E++ +R++
Sbjct: 3487 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3546
Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
LQQA+ + F D EL W V +K +S +DY + + + LR++ + L+
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3606
Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
++ + +E L QT TG EV ++ ++ R ++ + ++A T ++ L+
Sbjct: 3607 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662
Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
RLH E+L WL + E+ E A + + + + + +
Sbjct: 3663 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3719
Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
+ ++ +LLE MV + + + + + + A+ ++ +
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779
Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
L +T+ ++K SL ++ + AQL+ + E++ + + +L+++ ++
Sbjct: 3780 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3838
Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
C + +++++ V + + + + +R QLERA+ L+ +F + W
Sbjct: 3839 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3898
Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
+ + Q+ + E + + H+ LR ++ K Q +L
Sbjct: 3899 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3958
Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
Q+ +AA T +++E+++ D+ DQ+ ++ R ERL +Q
Sbjct: 3959 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4015
Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
E ++ E+I + VS+ L E ++Q + E + DK +A +
Sbjct: 4016 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4072
Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
K + + + + L++ R + V ELAE + H SL++ +D+I
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4124
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
+ L++P + P ++ + + + E+ +E + V G L+A P
Sbjct: 4125 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4179
Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
V + + L W+ L +A R +LE+ + +++ + W+ K+ ++ +
Sbjct: 4180 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4239
Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
G DLE Q L++F+ + + + ++L L+ K + + + +L
Sbjct: 4240 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4298
Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
W S ++ Q +LEGA L + LD + + E L+ + G D ++++
Sbjct: 4299 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358
Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
L KH L+ +V Q+ VE++ + L + S E A L+++ + + + W + + +
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418
Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
+R++ LD AL QA+ +++L L + R + + P P A+ L H E
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4476
Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
A ++ ++ GQQ+L A P S++ I Q + L+++ S+E E + +L++
Sbjct: 4477 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4535
Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
AL L + F +S++ WL E +L P ++ +L+ +HK+ + EV +
Sbjct: 4536 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4591
Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
+ +E G H + Q + ++ R E + ++ R L++ R + +
Sbjct: 4592 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4651
Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
F + ++ WL EK+L + E D + QL + + FQ L A R G
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711
Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
+ L + A + + + L EL W + S ++ KL++A + + +++ L +
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4771
Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
WL +E +L P G + V L+ + + + K+ +AL A+ +
Sbjct: 4772 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4830
Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
+ V+ Q + L R++++ ++T LEA R A+E + V L LA A
Sbjct: 4831 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 4884
Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
+ A+R L +QH+ ++ A G ++ H
Sbjct: 4885 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
H + + E+ +A + R L Q+ L LL W D E
Sbjct: 4945 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5004
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
+ E +AL+ + ++ P ++++ +T
Sbjct: 5005 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5039
Score = 150 bits (380), Expect = 2e-35
Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)
Query: 253 QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
+T+ +++ + QLQE L +++ + LL W+ + + +L A P S A
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3367
Query: 313 FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
F + + Q + +L QR L R T ++ + + E ++ + + L+
Sbjct: 3368 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3423
Query: 371 AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
A + R QL+ + +A++F +L E+ L + +E
Sbjct: 3424 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3483
Query: 431 VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
+ + LE I+ I L+ D+ + + + + W +Q
Sbjct: 3484 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3543
Query: 491 RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
R ++ + + L+ + +L +L ST + + +LQ
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3603
Query: 542 LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
LL Q +V E L + G V ++Q K + + + L L
Sbjct: 3604 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 601 EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
EQ LQ A L + EE WL + + G + SQ A + K L+ E
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3714
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
++A+ L L P + E+ A ++L+ + + + A+L Q
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3774
Query: 715 YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
F AA+A SW+ E + SL QDQ +A+ +V + F E+ R +
Sbjct: 3775 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3825
Query: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
+ + L G + +C + K L
Sbjct: 3826 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 3854
Query: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
D + ++Y+++ + R +LE A +L F + EL WL E Q+++ Q
Sbjct: 3855 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3908
Query: 889 P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
P + +TL Q ++ +A K +++ + QL + PG IQ +
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3968
Query: 947 WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
+ Q++ +++AV L ++ + F + L ++ +L S+E Q+
Sbjct: 3969 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4028
Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
++ K + ++ + LQ + +++ G ++ +Q +++ + + + +
Sbjct: 4029 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4086
Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
V +R + + + + F + L++ + Q +R ++ +D + ++ +
Sbjct: 4087 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146
Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
+ EEI QE L ++ S+ +AA PD V ++ L L W+ R L+
Sbjct: 4147 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4206
Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
E +Q + DG A W+ + +G D+ +++ ++F
Sbjct: 4207 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4260
Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
E L E L++ ++ HTV++ L ++ W L+ R R+ +L A L
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4320
Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
L +++ + EL+ W+ +GL++ +P G ++ L +H ++++LA + VEA+
Sbjct: 4321 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380
Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
+ G +L+ G+E ++Q +L+ L +W+ + K +R +L A +Q + +++
Sbjct: 4381 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4439
Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
D ++ L E L +S+ L + + Q H ++ E++ T + M M
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4499
Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
+A I ++ + E ++ L R +L+ ++ L H S + ++W+ +
Sbjct: 4500 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4559
Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
+ S L+ +HK EV +H+ Q+ + +G L Q +++
Sbjct: 4560 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4619
Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
++ W ++ + R + L A + F + S+L W+EE ++ L S + D
Sbjct: 4620 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4679
Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
+ +H+ Q+ L S + ++T ++L + + LR++
Sbjct: 4680 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4739
Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+ + R +LE L +F + L WL + + + D + ++L
Sbjct: 4740 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4799
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
FQ ++ + V A + A L+E V+ + Q+L T W + L+ ++
Sbjct: 4800 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4859
Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
ALR E V LLE L + E+ + D L + H+ ++L
Sbjct: 4860 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4918
Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
+L + V +C ++ + + AWA + Q+R A
Sbjct: 4919 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 4974
Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
L+A+ A+ + WA D E QE ++ HQ E+ ++
Sbjct: 4975 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5030
Score = 139 bits (349), Expect = 7e-32
Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)
Query: 824 DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
D + + + Q + + + L RL F EL+ + KQ L
Sbjct: 1573 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1632
Query: 884 LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
+ +Q A L + ENFL G+ L E + EQ N +I+ +Q L
Sbjct: 1633 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1685
Query: 944 SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
+ E L + + E + +++ ++ ++ ++L L + S
Sbjct: 1686 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1740
Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
+ K ++ + HF + ++ + E G + GQV T Q L Q ++V
Sbjct: 1741 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798
Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
+ ++ QA TQ+ Q L++ Q L E + Q KE+ V +A L E +
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 1855
Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
++ H QE L++ DA D E + L+ Q QEL+ L
Sbjct: 1856 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 1901
Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
L L+ QK F+ +H+ L ++ G V EA + R+ G+ + T
Sbjct: 1902 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 1953
Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
E R H +S + + + L+ + ++ + S LLA LQ E
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2007
Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
A + + E A +P +N+ + L+ +A + ++ + + VE L++ LL
Sbjct: 2008 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2057
Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
R + DIQ L + ++E L++ + ER ++LQ L R L QD +++
Sbjct: 2058 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2112
Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
G ++SS E GQ +S LQ ++ LE + + + A+
Sbjct: 2113 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2172
Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
S A + A S E + KH L ++ L S +L F L
Sbjct: 2173 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2232
Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
+ V +P T ++ + + S +HK+ ++ + S + +++ G P
Sbjct: 2233 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2280
Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
+ +V E+ L + E+E EA C +Q FQ + V L+ W++E
Sbjct: 2281 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2337
Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
+P + D G+ T +L K E+ +S L +T P
Sbjct: 2338 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2397
Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
+ + + + L++ A + +L
Sbjct: 2398 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2456
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
+L + E+ + WL + A + D E + F+ +++ +
Sbjct: 2457 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2514
Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
V + LLE P +Q ++ + W EL +LT R L ++ L +
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574
Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ L Q +E S+ ++ D L Q + Q L +E T + E L AG+
Sbjct: 2575 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2633
Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
PG V+++ AVTQ W L ++ R +++A + + ++++ +R +
Sbjct: 2634 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2693
Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
+ + L + S P + +L Q ++ E++ +K + A L + AL+
Sbjct: 2694 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2753
Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
E+ +L + V Q + LQ+ ++ R + + +E
Sbjct: 2754 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2813
Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
K+ + + ++ +E LI+ H+ F K LTAQ E + E L + + ++ + LQ
Sbjct: 2814 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2873
Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
+VKE +L +L + + WI L+E D
Sbjct: 2874 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 2930
Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
+ + K ++ + E+ H ++ + +LL+ V+ + L + + +
Sbjct: 2931 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2990
Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
+ + + LE+ + F EF + ++ +Q + ++++ D LG
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050
Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
Q L+H + L +RL + A D+ G SD+ LQ V+ I Q S
Sbjct: 3051 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3096
Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
L+ QQ E + + + + I +E Q + +L+S+
Sbjct: 3097 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3141
Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
+ R E L+++ I+A ++ LE + C + SP+ G++ +
Sbjct: 3142 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3200
Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
+++ +L RAQ R E ++ + + ++ + L+E + Q+ ++ E
Sbjct: 3201 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3260
Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
M + Q K E++ GQ L+ + +S GLE +L +
Sbjct: 3261 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3313
Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
W+ + QLQ+A L F ++E + W+ E+ +A++ P A + +
Sbjct: 3314 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3371
Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
+ + K+L+ L+ + + ++ + P + L + + R EAL +
Sbjct: 3372 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3431
Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
A TR +LE + + Q F + + + WL EK LV E + L Q+ + + +
Sbjct: 3432 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3491
Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
+ ++ + H Q + + + +Q +L+ + E+Q+ S + LQ+A
Sbjct: 3492 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3551
Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
C A EL NWL + +L +V + G+ + R L+ + + + +
Sbjct: 3552 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3611
Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
QA + L Q ++ +Q++ A++AR ++D
Sbjct: 3612 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3646
Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
KL A+ Q+L R L H+ L E E+ S+E T+V+ G
Sbjct: 3647 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3695
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
E A++ Q K L+ EA + LL E L EL+ W A
Sbjct: 3696 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3738
Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
G + +ED + + +++E +++A R ++ Q A
Sbjct: 3739 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3781
Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
A+L + E +L+ + R Q QL + T+ + +D D
Sbjct: 3782 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3830
Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
L VK + A +E + + K+ + K T+ + RY ++ +S + WE
Sbjct: 3831 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3888
Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
++ TE Q ++L E ++R Q++HR+
Sbjct: 3889 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 3925
Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
L + + + ++ +L +L P + + A TL ++ +E +
Sbjct: 3926 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3985
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
++Q+ Q H + + E L ER L ++ +V ++ + +++ + ++ + +
Sbjct: 3986 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4043
Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
+ L+Q G++++ S +++ + ++ +L ++ W
Sbjct: 4044 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4082
Score = 136 bits (342), Expect = 4e-31
Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)
Query: 469 VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
VA RQ+E + Q + L Q + + + +A + VE +Q EELQ+ + +A
Sbjct: 1581 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1640
Query: 526 CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
Q LAEVV E L + D L EA++ ++ Q ELD
Sbjct: 1641 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1697
Query: 568 LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
+ T+++ K + QL++S + + ++EQ Q
Sbjct: 1698 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1757
Query: 608 EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
+ EE+ + + +G + QK KA E + +HQAV +
Sbjct: 1758 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1817
Query: 667 GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
L + P+ E+ + ++ + + LQ + AD E
Sbjct: 1818 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 1877
Query: 722 AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
WL++ LE G D T L+R + + +LR + G A
Sbjct: 1878 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 1937
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
SC G + D + + DH +
Sbjct: 1938 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 1965
Query: 841 QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
+ SL + + L++ + + +SCG L
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2025
Query: 874 QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
Q LE+ L ++ Q +E ++ E L A ++ + + + RY S
Sbjct: 2026 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2085
Query: 934 TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
+ + E+L + L S+ V L E + L + +
Sbjct: 2086 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131
Query: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
S+ ALQ K ++LE+ + QS + + E + +LQ +K +
Sbjct: 2132 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2186
Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
+ ++ + + ET A+ L+ +L +E +Q L +K EV V L
Sbjct: 2187 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2246
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
+ Q+ E ++ L+ L + + ++ S +P+ ++ ++ L +++ +
Sbjct: 2247 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2300
Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
++E E + ++D F + ++W+ ++LG+ + + L
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2360
Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
+Q+ G L+S + A+A+ A G ++ + A +T
Sbjct: 2361 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2420
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
+ L SI+ T + E L +A L +LQ+ +++ + +MQW+++ A
Sbjct: 2421 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2480
Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
P+ ++T ++++++ E+EL V+ L+ ELL P E + +
Sbjct: 2481 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2540
Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
L + SKW+ LN+ +R +L+++ L Q Q + QL+Q +E L S G
Sbjct: 2541 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2597
Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
L + QQ++ E T + L + G+ + P + E+
Sbjct: 2598 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2657
Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
++ + L G L+ R + QA V+ Q+ L S+++ + P + +
Sbjct: 2658 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2717
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
L AQ + ++ ++ + ++K Q + + L L A Q + I++ Q+
Sbjct: 2718 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2777
Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
E H L+ AC + Q Q + FQ + LD + E + K ++ S +D+
Sbjct: 2778 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2836
Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
+ A + K A E L + E+ Q T +V E++ ++E
Sbjct: 2837 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2896
Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
L + L+ L+E+ D E E ++ +L +E + G +
Sbjct: 2897 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2956
Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
A S+ E D E H+ C KF +FQ +V
Sbjct: 2957 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3015
Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
S+R C A+ L+ S G M++ +Q+ LQ A +
Sbjct: 3016 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3072
Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
E + ++G L ET + H L + QV EK + L N R++
Sbjct: 3073 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3129
Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
+ +L S + R+ ++Q L+ L+ + K C P
Sbjct: 3130 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3189
Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
+++ +A+++ L R + R Q+E + L F + +++++ + Q +
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3245
Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
E SQ P + Q + + E+E + Q LGQ + +A T
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3300
Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
+ L+ D V W +++ Q Q Q L CGR ++ L + +E+
Sbjct: 3301 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360
Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
+ + V+ I++ ++ ++L + ++ E++ T P ++ +L +
Sbjct: 3361 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3420
Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
L R + AE+R L S++ F + +W+ ++L P G KL
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3480
Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
+ + +H+A E ++ H + + G++L S ++ Q + W
Sbjct: 3481 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3540
Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
E L+QA+ ED + +L V +K K++V D + Q
Sbjct: 3541 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3593
Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
R+ + V A + + LK +EV II + + R+
Sbjct: 3594 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3649
Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
+ LE AL+ +H EL ++ E E L K E+ Q +R +E
Sbjct: 3650 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3707
Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
L++E +A ++SL L + P A GL E E + + ++ E +D
Sbjct: 3708 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767
Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
A L Q QA EL + + M + L+ + E+ D
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827
Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
I +G +++TA +++ L + + ++ E LQL++A L F
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887
Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
+ E++ WL + ++ L P E L +H+ L + I + T
Sbjct: 3888 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3945
Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
L + E S + A + R L+E ++ L+ +
Sbjct: 3946 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4005
Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
+ LR+ ++ E + Q+ + +N +++ + L++ G+ ++ G
Sbjct: 4006 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4060
Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
G +++A+Q++L+++ +W + +++ AKL C+ + L ++++
Sbjct: 4061 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4120
Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
++++ +E P+V + E + G Q EL+ ++ + A G+ +
Sbjct: 4121 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4179
Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
V++ L + SL + ++R L EA +++ WV
Sbjct: 4180 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4230
Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
LA+ G L V+ E+ Q +E E +H+A L + V K
Sbjct: 4231 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4287
Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
H V + +L+ L R+ L+ A A QF L E +WL G
Sbjct: 4288 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4341
Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
+ + + +G +A + L + + D+ A +E + + L+ES E+ +
Sbjct: 4342 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4401
Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
+L+ + + +L + E R HG E LQ + E LL +
Sbjct: 4402 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4461
Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
+ +E E K + ++ +Q GQ + K A T +I
Sbjct: 4462 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4510
Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
+ ++ WE ++ + R E L A E H+ Q + Q + L
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4568
Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
L +V +H+ E+ + +++ L L L K VQ W
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628
Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
+ + ERG+ L A + F +L+ W +E ++ SE E+A D + L
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688
Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
QH+E + + + G+ L + + + +L+ L EL + W
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4738
Score = 132 bits (331), Expect = 8e-30
Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)
Query: 306 MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
+ Q L F +F+ +E P ++ L L + L H+ L +++ W
Sbjct: 3260 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3316
Query: 366 AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
L A R+ LQ+ LL RFQ S++ D E+++ + P A
Sbjct: 3317 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369
Query: 426 TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
V+A +Q +L+ ++ +EG + AE AD ++ + ++
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3420
Query: 476 VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
+ RW+ LL + + +Q+ + V E +E + L +++ R C G Q +
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3478
Query: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
++ E + +H LE + H H+ S+G S++VL + K ++L S
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3530
Query: 589 LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
V + +R LL+Q L A+ E E WL E ++ ++ ++
Sbjct: 3531 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3590
Query: 642 ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
Q + L+ ++ + + G +L + G+ +Q + ++
Sbjct: 3591 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3640
Query: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
AR + + A E A L R S C LL ++ +
Sbjct: 3641 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3697
Query: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
A A++R E + A + +A L ++N S E + W+
Sbjct: 3698 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3740
Query: 821 AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
E D D ++Q E + A A LR + ++A + EL W+
Sbjct: 3741 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3790
Query: 878 EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
EK+ + L ++ + D + F + K + ++ S ++ Q +
Sbjct: 3791 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3850
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
+++ +++ + + + + E+ +QL + + + +E P + + ++ QL A
Sbjct: 3851 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 3908
Query: 993 PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
P +T Q Q + L+ E + H + ++ E E +Q + L
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3968
Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
Q++E V +RA E ++ + F + Q+L E + +LR +S +V + +
Sbjct: 3969 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4028
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
E++++ ++ Q + L + + M A +++ + + + + ++ +WE
Sbjct: 4029 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4086
Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
+R+ L + +EL +KF + T + Q ++ L++ G E
Sbjct: 4087 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146
Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
+RE + LQ+ + ++ LG +E + A GE P V++ + + + W L
Sbjct: 4147 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4194
Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
+ R +L ++Q QD + + W++ G +A+ P G + Q ++ +
Sbjct: 4195 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4254
Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
+SE + +E L ELL ++ + D +Q L L+ W++L ++ R
Sbjct: 4255 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4313
Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
+L+ A GQ + L +L L EG L + G D ++ + +H L+++
Sbjct: 4314 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
+ + A+ + + S A EE +LE+L R QL ++
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429
Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
+ H +L W+ + H G P + E LN H E+ +A
Sbjct: 4430 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4482
Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
+ + ++ G+ + A A+ ++Q L+ W +E R L++A+
Sbjct: 4483 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542
Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
F + + + W+ + V+SR + + I++H+ E+ + + ELD+T
Sbjct: 4543 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4601
Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
L ++Q VV Q R + ++ L E + D + + HE +
Sbjct: 4602 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4658
Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
L WL +++ + DP+ + +FQ + SL E
Sbjct: 4659 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4716
Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
+ A ++ +L+ W + + R + L + D L+ L
Sbjct: 4717 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4776
Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
E + V D+ + + +H+ ++EL +Q L +A ++L G + +
Sbjct: 4777 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4833
Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
V+ + Q ++ W + ++ +LE A R F + V W A Q L+
Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4893
Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
+ L H+ +LE + +AT +G L + + +
Sbjct: 4894 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
R + WA++ ++ A L ++ LE +LA + + T + +EEV
Sbjct: 4954 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5012
Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
+ LI +H+ F++ +T +K+ + + KT +R R D P LQ + V + +
Sbjct: 5013 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5066
Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
AS L S +Q + ++ W Q W L+ D D+L+ L + F+
Sbjct: 5067 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5126
Query: 2161 AEV 2163
++
Sbjct: 5127 FDI 5129
Score = 110 bits (275), Expect = 3e-23
Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)
Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
++ L Q +T ++ + V +L WV+E + + ++G D + + H+ + +
Sbjct: 619 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 678
Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
+ SS++E + +T P ++ +++ RL Q L + ++R L+ LH F
Sbjct: 679 EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 733
Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
+ A + WL ++K+ + E + A+ +++ + + + + +AE
Sbjct: 734 VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 792
Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
LL H A + + +QT WS + +L Q +++ D E ++
Sbjct: 793 QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 852
Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
++ + C + + + L +E + + +ELL+ + L
Sbjct: 853 LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 896
Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
+ +A ++Q + L+ + + A+ DY Q+E + +
Sbjct: 897 -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 937
Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
L ++H RA+ W+ + G +A++ P KE + ++ Q
Sbjct: 938 DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 987
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
V W +++ + E ++ I A+ S+KT G + + L +
Sbjct: 988 YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1044
Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
E FL +D +E+ + + + + Q ++ E E +L
Sbjct: 1045 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1097
Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
++ + E+ +Q++ P+ DL + + + + + + E++ ++ + ++
Sbjct: 1098 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1157
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
K E +Q+ + + R + L +++ Q ++ ++ + L+ AEA
Sbjct: 1158 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1216
Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
++ E K+ N+ +L L+ Q R + E R ++ D + A ++I
Sbjct: 1217 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1271
Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
SD + + ++ QL RW + H Q++ L
Sbjct: 1272 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1311
Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
+DLE + + L+ + + HP+ ++ +E ++ + PE
Sbjct: 1312 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1352
Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
+ L + QQ++ S +++ QK E A + +LQ M +V +Q+
Sbjct: 1353 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1409
Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
+SPV+ RRM E +D T +L Q + AG
Sbjct: 1410 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1453
Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
L LE+E SLE +EH +++A ELQ ++S++ K ++ + S+E
Sbjct: 1454 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1510
Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
S E L + L ++ L KH KM + + ++ L+ + L + Q +
Sbjct: 1511 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1570
Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
+ K RQ + E+L+ + L + E L+ +E +
Sbjct: 1571 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1618
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
T L KQ+ Q ++ S E+ + + L + G S+ I+++L E
Sbjct: 1619 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1678
Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
+L + S+K++ K+ +K +L S ++EN WL ++ + R
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1738
Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
A T +G+ G LL TQ L K
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798
Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
Q E ++ Q QA + ++G L+ + +E+ ++ ++ K +L E ++
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858
Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
+ + L KF D E W+Q+ + L + ++ + ++ ++ ++ S
Sbjct: 1859 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1918
Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
H+ R + +G ++++A + +V ++L+ A R+ ++ +L
Sbjct: 1919 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1978
Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
++ +A L ++ H +E + L R+LE TK
Sbjct: 1979 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2038
Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
+ + +E+L++TA LL++R + P + L + + +L + R LQ
Sbjct: 2039 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2098
Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
L ++ L +LD W+ ++ + Q QD+ ++ E+ A R
Sbjct: 2099 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2153
Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
Q+ + A+ K+ +E P +QA+ + A R +A E LA E
Sbjct: 2154 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2207
Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
V F+ + +LQ ++ KT AL + + G ++ + Q +H++ L
Sbjct: 2208 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2267
Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
++ KE++ P A V E L K +E + + +
Sbjct: 2268 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2315
Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
AF + L +W +E + + GAE L E+ + + L+ +++
Sbjct: 2316 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2372
Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
+ + + +SA T + EG EE WA + GL
Sbjct: 2373 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2424
Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
+++ + D H D+ LLL + L KL AQEE A
Sbjct: 2425 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468
Query: 3444 MQ 3445
MQ
Sbjct: 2469 MQ 2470
Score = 108 bits (270), Expect = 1e-22
Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)
Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
+VAS + +L EHQ +L + Q R + SQ D ++ + V Q Q
Sbjct: 1022 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1078
Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
EL E+ +Q E + EV N + L D+L E V
Sbjct: 1079 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1135
Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
+ +E RL LG + S + T+R +L + ++ S
Sbjct: 1136 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1193
Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+L ++ L AE + + E L + NI + + SE+
Sbjct: 1194 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1252
Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
R+ AL+ EL + E +T + L +W+ ++ ++
Sbjct: 1253 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1309
Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
R +L+ G+ + R L D +Q+E + +Q ++ + +L ++ + L S
Sbjct: 1310 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1368
Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
E +KM A +A+ E R + Q ++ ++Q+S +L +
Sbjct: 1369 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1428
Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
F L + V T Y + + + L + K L+ E K H Q V
Sbjct: 1429 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1482
Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
+ + + +G P +E+ +L A + T Q +
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1527
Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
L D DE L + + LQE + +S E L Q ++ T +
Sbjct: 1528 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1573
Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
V ++++V ER +E LQ L T +R + +GT+ L ++ + E+LQ
Sbjct: 1574 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633
Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
+ QA + GE L ++ + + AK + +
Sbjct: 1634 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1693
Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
++ +++VAA + L ES + + + +D + A ++ ++ + G
Sbjct: 1694 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1752
Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
++ + V+ +LLE T V + + N+ + ++AQ + +
Sbjct: 1753 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1810
Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
+ + Q LLE G Q L P + + ++ L ++ + L
Sbjct: 1811 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1868
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
+F ++ W + Q+L+ E+ + +G + KL + ++ + + + T
Sbjct: 1869 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1928
Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
G + L AA + +K EVQ +L D+ +Y L+ ++
Sbjct: 1929 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1988
Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
+ CG L + A + + K + +V+ + L R+ E K L Q +
Sbjct: 1989 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2046
Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
E+LK + R +L +Q+ + R ++L++S R L +L + S
Sbjct: 2047 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2106
Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
+ DW+ LKE P+ L+D + K+ E ++ + + ++ +K
Sbjct: 2107 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2163
Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
+ + + P A + +++ L + + ++E+ + +E + + + +
Sbjct: 2164 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2223
Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
+++ K + D+ G+D+ Q ++ EF + V + ++ IS L
Sbjct: 2224 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2278
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
P + ++ ++ + L+ ++ + ++ + E VL + L + K +K
Sbjct: 2279 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2337
Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
++Q A D GK LE ++L K E+ + SL + + + A
Sbjct: 2338 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2397
Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
G + A E +W L+ + + L
Sbjct: 2398 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2457
Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
L +AQ+ + + + L + + +PAP + +E+++ +AEL + +
Sbjct: 2458 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2517
Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
+ +LL R +Q L+ ++ WQE +QL + QQ LE L
Sbjct: 2518 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2572
Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
F + ++++WL KE ++ G PL+ +L + ++L + + + L
Sbjct: 2573 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2629
Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
A +G+ G P + + A + +K ++L Q R +++ Q Q+ L+
Sbjct: 2630 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2689
Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
+ + L K +L AM QL+ Q + E+ Q Q L +
Sbjct: 2690 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2748
Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
L++ + +E + +LE + + +++ ++ V LQ AC + + ++ + + WL+
Sbjct: 2749 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2807
Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
E + ++ + L + L+ ++ + ++ E + + + ++
Sbjct: 2808 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2867
Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
++ Q + + + + ++ER L E+ LK+ + W+ Q L +
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927
Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
D + +++ L ++L+ EM H + ++ T L+ V + L
Sbjct: 2928 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 2983
Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
+ + + + ++ L+ Q+ ++F E+ L LD D S +
Sbjct: 2984 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3043
Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
L L+ ++ L+A +++ ++ A ++E+ + + VL Q++ + + H+ L ++ +
Sbjct: 3044 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3103
Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
+ L+ +LQ + ++ + D L + A G+D E ++ +E
Sbjct: 3104 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3157
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
AF K++++L + A + L P + + +EA + Q K
Sbjct: 3158 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3212
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
A +V + E +++E + L+ K E+ S V T+ QQ +
Sbjct: 3213 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3272
Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
E+E ++ + Q + LGQ + AA L V W TL K +R
Sbjct: 3273 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3328
Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
L +A F + LL+W + +EL ++++ + Q ++L Q + + R
Sbjct: 3329 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3388
Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
+ +++EG+++ + ++ + L L+ R + L +A Q S Q+
Sbjct: 3389 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3448
Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
+ LE WL E L+ + G S +E + +H+ LE
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3508
Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
K+L+++E+K K + Q ++ QE R+
Sbjct: 3509 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545
Score = 93.2 bits (230), Expect = 4e-18
Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)
Query: 246 CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
CS + Q+++++L K+L LQL+ + L Q+ + +L W+ E Q
Sbjct: 3842 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3900
Query: 292 MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
+ LPA L T+ + QE+ +L++ L+ + + N+
Sbjct: 3901 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 3946
Query: 349 --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
P EG + E + + + + +++R + L + + +F K +
Sbjct: 3947 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4000
Query: 407 LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
L+ E+++++ R PP+ A VE +++ + + E + Q L E +E
Sbjct: 4001 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4059
Query: 465 -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
S V + +++ W+ + ++ + ++ D+ + +SL+ ++
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4119
Query: 510 ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
+ +L++P + +Q E E ++ D L+ ++ S L E D
Sbjct: 4120 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4178
Query: 569 GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
+++ L SL + R LE+ +Q A ++ + W+ G ++
Sbjct: 4179 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4233
Query: 628 GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
+ + +G DL + +++ K ++E ++ Q + ++ + +L ++ + D +
Sbjct: 4234 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4292
Query: 687 AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
+ W L+ R++ R +L+ ALL L F A E +WL L E+ G D
Sbjct: 4293 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4352
Query: 742 QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
A E L +H L+ + A + + A++ G L
Sbjct: 4353 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4392
Query: 802 WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
EAS + + L+Q ++++ + R+ +L+ A+
Sbjct: 4393 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428
Query: 862 -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
GF +LQ WL E+ + + + +T + + A + +
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4488
Query: 918 VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
+ +Q+ R P ++ T I + L ++W +E E+ +L E + E
Sbjct: 4489 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4545
Query: 977 TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
+ + L Q E A +P DT Q+ + K E H + ++++++ G
Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4602
Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
+++ Q ++ + ++Q ++V +++ +R R + + R + F + +L+ W
Sbjct: 4603 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4662
Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
E + L S+ E++ D + L +H++ + + H + + + +L
Sbjct: 4663 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4721
Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
D+ ++ + L L + + +RQ L+E L G+ D A WL+
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4775
Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
L E D+ ++L+ H+ F + L +AL+ +L++ + V
Sbjct: 4776 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4835
Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
+ Q+Q + +W + S ++ +L A+L Q +E+ V L++W+ E + + H
Sbjct: 4836 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4895
Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
+ L+TL +H+ +L R + +G +L+ C + I T W
Sbjct: 4896 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 4948
Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
+ R E + L A Q +Q L L +E LE L LQ +ET + + +
Sbjct: 4949 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5006
Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
Q++E +A + M P + + T+ + RR LQ H+ +
Sbjct: 5007 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5056
Score = 58.5 bits (140), Expect = 1e-07
Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)
Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
Q ++E ++ +QD +++++ L +E G DL S + + H+ + E ES
Sbjct: 625 QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 684
Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
AK++ + A P L +K L RLE L + ++ LH F +
Sbjct: 685 KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 737
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
EL W+ E ++E H EL E+ + ++ V L
Sbjct: 738 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 797
Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
HP I ++ W+ + + C+ Q +++ + ++F D E ++ + +
Sbjct: 798 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 857
Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
R Y D ++++ L+ + +EEL Y S++ L A+T+
Sbjct: 858 -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 903
Score = 57.0 bits (136), Expect = 3e-07
Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)
Query: 209 VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
V E + + +LL+ P + ++T + + ++L T+ R+ +L+E
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2565
Query: 269 TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
+ TQ++ + A L +W+ EK++ + P+ L RQ + KP
Sbjct: 2566 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2625
Query: 325 LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
Q A + +L R + + R + + LA ++Q W L + R + Q ++
Sbjct: 2626 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2679
Query: 385 QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
+ + ++L R K + ++ L + V A L T + Q + + I
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739
Query: 445 EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
QAL E L +E+Y A+++R+ E + ++ + Q + + L
Sbjct: 2740 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2784
Query: 505 QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
Q A+SHQ +++ +E +S +L + L++ H ++A
Sbjct: 2785 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2842
Query: 553 HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
SH+ ++T +L G+ LQ + T+ + V+ R L+++L++A
Sbjct: 2843 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2900
Query: 608 -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
++ E W+ +C + D ++ ++ K K+L+ E+ +H
Sbjct: 2901 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 2950
Score = 40.4 bits (93), Expect = 0.032
Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)
Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
+L + E + + G L SV + + H+ + R +E E + + ++ ++
Sbjct: 639 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 693
Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
AP L +++ +A L ++ + + L H F+ R L W E++E
Sbjct: 694 MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 750
Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
+ + +E + H EL +E+ + + +++ +QL+ +H A +T
Sbjct: 751 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 804
Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
+E ++ W+ Q C Q + Q +++ A+ + DY ++ D
Sbjct: 805 -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 856
Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
+ R ++ ++ K + + ME+ E LLQ + G + T Q +P
Sbjct: 857 --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 908
Score = 40.0 bits (92), Expect = 0.042
Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)
Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
Q LL W + +Q QL E D+ S + L H+++ I ++ L++ M A
Sbjct: 638 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 696
Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
P L L + Q K+L R Q ++ + F + N WL
Sbjct: 697 --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 744
Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
+ + + D E + + + H E R L ++++ E+L+ HPA T
Sbjct: 745 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 804
Query: 1250 VREQLQSIQAQWT 1262
+ ++Q QW+
Sbjct: 805 IEAYRAAMQTQWS 817
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 222 bits (566), Expect = 5e-57
Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)
Query: 408 KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
K+ ++ L++ +A +++ + AV++L +L+A +LP + Q + DI+ +
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2091
Query: 461 EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
+ S V R E++ + R L G + + M V S L+E + Q P
Sbjct: 2092 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2141
Query: 521 ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
STA + +++ ++ +LE ++ + ++ + ++ + ++++ ++ LQAK
Sbjct: 2142 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2194
Query: 580 RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
+ L+ + A +E+ + E N E+ + +L+ Q + + G+D++
Sbjct: 2195 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2254
Query: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
+++ +Q+ + E +H V L++ ++S+ P+ E+ + ++ ++
Sbjct: 2255 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2311
Query: 697 TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
+ + + + L F ++ SW++E + ++ Q AE L L
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2368
Query: 753 VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
+L+ E++++ G SL + SA++ P +++ S + G G
Sbjct: 2369 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2420
Query: 813 DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
A +F N +I + +S YE L L + + A L ++ L
Sbjct: 2421 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2473
Query: 868 SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
+ WL+K + Q P E ++ + E +F L E+
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2533
Query: 923 EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
+L + P + +Q E+ +W +L L ++ +L S + L + + Q
Sbjct: 2534 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2590
Query: 981 LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
L+ L++ E L P S + Q Q + L+ E Q + G S+
Sbjct: 2591 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2649
Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
P G+ +L+G++K+ V Q+ + R ++ ++ Q LL +
Sbjct: 2650 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2707
Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
L +K VS + + L Q + +EI +++++ A + ++AL +
Sbjct: 2708 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2767
Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
E+ L + + ++++ E Q LQ + Q+ R+ + T Q H
Sbjct: 2768 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827
Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
+ DV E SL++ H++F + L+ E A GE L+ ++Q ++ QL +
Sbjct: 2828 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2885
Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
I+ W + ++R +L SL+ ++K+ V L W+++ + + +P+
Sbjct: 2886 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 2945
Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
+I + ++ + E+ VE L LLS +E + + L K + +
Sbjct: 2946 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001
Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
+ MT++ E Q+ ++ + RQLQ AKEQL+ + + + + L Q
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3059
Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
QK Q L+ + ++ LA + AS + G S +L+ ET Q+H + +
Sbjct: 3060 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3117
Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
+ +LQ + + + + +P A++L +K KE +
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3168
Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
KA +++ +++S + + A+ + + +QC +L E
Sbjct: 3169 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
E + L++ + +++ + + + E E + P+ + + ++ K +
Sbjct: 3229 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3288
Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
LQ ++ + W + L Q+A T + E + + + + L + A R +L E
Sbjct: 3289 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3344
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
L F E L W+ ++ + P A K K Q Q + QR+
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3396
Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
R +++R +A P + ++ L + W L + R L
Sbjct: 3397 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
+ + LE L + EK + LE Q+ H+ LE +++ + L + +
Sbjct: 3457 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3516
Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
+ G+ K+ + + Q + +Q W + +Q + R L++A A+ F +
Sbjct: 3517 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3575
Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
+W V L + G K + + L+ ++ R++ QA G + L
Sbjct: 3576 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
G +Q++L A++ + + + + L+ Q L C L+ E
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
+L+ + LK + ++L ++ + +L + ++ +AL E + R +
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
+ +R V + + + A++L + F QAA WI ++L + GD+R
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3812
Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
D+ L+ Q F E+ H++++ + K G ++ A S + ++L + K++
Sbjct: 3813 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3872
Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
+ + Q + R +LE ++ + +F + + W+ E + + L Q E
Sbjct: 3873 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 3932
Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
QLR + E + + I ++ QL P E I ++ + ++
Sbjct: 3933 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3982
Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
++ + L+ A+ + +D + + ++ E L Q ++E ++ + ++
Sbjct: 3983 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
+ + ++ +Q E+L++ + RS +A ++ + ++ W + + ++
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
R + LD + A+K L+V+ + + + D P ++ E + + E+
Sbjct: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
D + + + + G +L+ A G P +++ + L SL AW++ +L++A++
Sbjct: 4163 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
+ + ++ + W+ LAS + L ++ + + K + + Q ++ L
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
A L + E+ + M L+ ++L + R+H+LE L L F E
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
+ AWL + E+ + D + +L K Q ++ A + + + G L++
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
G AS +Q +LE L W + + ++++ +L A +A +E+L+ WL E
Sbjct: 4403 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
L A LP E L E+ AA + K ++L+ + Q + A+ ++++
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521
Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
L ++++S+ L ER+T LE A +L ++F + + W+ Q + L A
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581
Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
L V ++H+ +E++SH + TG L +F+ + ++ L
Sbjct: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4638
Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
EK + L R R L + A+QF + WL E LDSE ++ + + +
Sbjct: 4639 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4695
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
L + + ++ L A + +T L+ + + ++ K+ L +R+ + +
Sbjct: 4696 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755
Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+ R + L+E L + L L+D + AE Q D++ V L + AF+
Sbjct: 4756 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4815
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
KE+ + V AL++ A L G+ ++ Q + WE + ++ L AA
Sbjct: 4816 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4874
Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
VH+ + AE + ++ L ED ++RTL QH+ ++LE
Sbjct: 4875 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 4928
Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
E+ + T + L P + ++ ++A+ +E W Q A A
Sbjct: 4929 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4986
Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
L QEL L WA+ E + +++ + L+ +H+ +E+
Sbjct: 4987 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Score = 209 bits (531), Expect = 5e-53
Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKWIN + + +LY +L DG +L+ LLE++SG+ LP +GR+R H
Sbjct: 75 KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 131
Query: 79 FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +L R +V + I ++I DG+ L LGLIW IIL FQIS I + E
Sbjct: 132 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 191
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
SA KE LL+W Q+ T Y + +F+ W DG FNA+IH +RPDL+D ++
Sbjct: 192 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 246
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE ++G+ +LLDPEDV + PDE+S++TYVS Y ++ +G
Sbjct: 247 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 303
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
+ + E+ +Y+ +V L++WI + R FP++ ++ L + F+
Sbjct: 304 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 357
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
E PP+ ++ + L L+ ++ + +G ++ + W L A R +
Sbjct: 358 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 414
Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
AL+ + +L+ L+ +A R Q + + E L A L L
Sbjct: 415 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 458
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
E+G+ +FQ AEIA + + + RQ + V Q L+ Q Q+ +
Sbjct: 459 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 503
Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
Q V L E+ A ++ + R Q + + Q + AQ + H + S L
Sbjct: 504 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 562
Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
Q T L SS TS VE + L
Sbjct: 563 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 622
Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
Q+++ L+ + +LL+Q L E ++ ++ W+ E ++ G DL +
Sbjct: 623 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 677
Query: 643 LQKHKALEAEVHR 655
L+ HK VHR
Sbjct: 678 LENHK----NVHR 686
Score = 203 bits (516), Expect = 3e-51
Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)
Query: 872 ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
+ Q WL+ + + P + D LE + +++F L ++ + + E L +
Sbjct: 2811 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 2870
Query: 929 YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
G+ +Q Q + W +E+ +L S+E +E T Q
Sbjct: 2871 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 2930
Query: 980 QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
L ++ L P E++ L+ QK+ +L + L SV +E
Sbjct: 2931 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2987
Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
E++ L +V+ L+ + ++ +E +V++ ++RQ + Q + +S
Sbjct: 2988 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3047
Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
++ L++++ S+ L+ DL + + AQ + A D
Sbjct: 3048 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3090
Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
+ +V + + Q+ L +++ +L+ L+ + F + + A L
Sbjct: 3091 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3148
Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
D++ R+A +L +Q L L EAL A + + P
Sbjct: 3149 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3204
Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
++ L+++ Q +L R++ R Q+ +++ L+E+ + E L+Q EE +
Sbjct: 3205 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3262
Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
P G L K + E E L ++ + + +G+ L+ + + + ++ L
Sbjct: 3263 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3320
Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
+ ++W+ LN+K+ +R +LQ+A E LL + D +E + Q + +
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380
Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
++ + LQ+ +S + + +A+ A A IL++ R E L
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3439
Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
R QL+ + + H+ N L+ + + + + P T+ + + +
Sbjct: 3440 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3497
Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
HK L+ ++ H + + +S G+SL + + +V+ + W E++ +R++
Sbjct: 3498 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3557
Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
LQQA+ + F D EL W V +K +S +DY + + + LR++ + L+
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
++ + +E L QT TG EV ++ ++ R ++ + ++A T ++ L+
Sbjct: 3618 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
RLH E+L WL + E+ E A + + + + + +
Sbjct: 3674 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730
Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
+ ++ +LLE MV + + + + + + A+ ++ +
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
L +T+ ++K SL ++ + AQL+ + E++ + + +L+++ ++
Sbjct: 3791 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3849
Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
C + +++++ V + + + + +R QLERA+ L+ +F + W
Sbjct: 3850 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3909
Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
+ + Q+ + E + + H+ LR ++ K Q +L
Sbjct: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3969
Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
Q+ +AA T +++E+++ D+ DQ+ ++ R ERL +Q
Sbjct: 3970 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4026
Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
E ++ E+I + VS+ L E ++Q + E + DK +A +
Sbjct: 4027 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4083
Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
K + + + + L++ R + V ELAE + H SL++ +D+I
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4135
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
+ L++P + P ++ + + + E+ +E + V G L+A P
Sbjct: 4136 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4190
Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
V + + L W+ L +A R +LE+ + +++ + W+ K+ ++ +
Sbjct: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250
Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
G DLE Q L++F+ + + + ++L L+ K + + + +L
Sbjct: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4309
Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
W S ++ Q +LEGA L + LD + + E L+ + G D ++++
Sbjct: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
L KH L+ +V Q+ VE++ + L + S E A L+++ + + + W + + +
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
+R++ LD AL QA+ +++L L + R + + P P A+ L H E
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4487
Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
A ++ ++ GQQ+L A P S++ I Q + L+++ S+E E + +L++
Sbjct: 4488 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4546
Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
AL L + F +S++ WL E +L P ++ +L+ +HK+ + EV +
Sbjct: 4547 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4602
Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
+ +E G H + Q + ++ R E + ++ R L++ R + +
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662
Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
F + ++ WL EK+L + E D + QL + + FQ L A R G
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
+ L + A + + + L EL W + S ++ KL++A + + +++ L +
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782
Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
WL +E +L P G + V L+ + + + K+ +AL A+ +
Sbjct: 4783 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4841
Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
+ V+ Q + L R++++ ++T LEA R A+E + V L LA A
Sbjct: 4842 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 4895
Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
+ A+R L +QH+ ++ A G ++ H
Sbjct: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
H + + E+ +A + R L Q+ L LL W D E
Sbjct: 4956 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5015
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
+ E +AL+ + ++ P ++++ +T
Sbjct: 5016 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5050
Score = 150 bits (380), Expect = 2e-35
Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)
Query: 253 QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
+T+ +++ + QLQE L +++ + LL W+ + + +L A P S A
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3378
Query: 313 FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
F + + Q + +L QR L R T ++ + + E ++ + + L+
Sbjct: 3379 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3434
Query: 371 AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
A + R QL+ + +A++F +L E+ L + +E
Sbjct: 3435 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3494
Query: 431 VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
+ + LE I+ I L+ D+ + + + + W +Q
Sbjct: 3495 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3554
Query: 491 RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
R ++ + + L+ + +L +L ST + + +LQ
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614
Query: 542 LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
LL Q +V E L + G V ++Q K + + + L L
Sbjct: 3615 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 601 EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
EQ LQ A L + EE WL + + G + SQ A + K L+ E
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3725
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
++A+ L L P + E+ A ++L+ + + + A+L Q
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3785
Query: 715 YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
F AA+A SW+ E + SL QDQ +A+ +V + F E+ R +
Sbjct: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3836
Query: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
+ + L G + +C + K L
Sbjct: 3837 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 3865
Query: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
D + ++Y+++ + R +LE A +L F + EL WL E Q+++ Q
Sbjct: 3866 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919
Query: 889 P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
P + +TL Q ++ +A K +++ + QL + PG IQ +
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3979
Query: 947 WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
+ Q++ +++AV L ++ + F + L ++ +L S+E Q+
Sbjct: 3980 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4039
Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
++ K + ++ + LQ + +++ G ++ +Q +++ + + + +
Sbjct: 4040 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097
Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
V +R + + + + F + L++ + Q +R ++ +D + ++ +
Sbjct: 4098 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157
Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
+ EEI QE L ++ S+ +AA PD V ++ L L W+ R L+
Sbjct: 4158 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4217
Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
E +Q + DG A W+ + +G D+ +++ ++F
Sbjct: 4218 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
E L E L++ ++ HTV++ L ++ W L+ R R+ +L A L
Sbjct: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
L +++ + EL+ W+ +GL++ +P G ++ L +H ++++LA + VEA+
Sbjct: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
+ G +L+ G+E ++Q +L+ L +W+ + K +R +L A +Q + +++
Sbjct: 4392 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4450
Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
D ++ L E L +S+ L + + Q H ++ E++ T + M M
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4510
Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
+A I ++ + E ++ L R +L+ ++ L H S + ++W+ +
Sbjct: 4511 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4570
Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
+ S L+ +HK EV +H+ Q+ + +G L Q +++
Sbjct: 4571 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4630
Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
++ W ++ + R + L A + F + S+L W+EE ++ L S + D
Sbjct: 4631 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4690
Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
+ +H+ Q+ L S + ++T ++L + + LR++
Sbjct: 4691 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4750
Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+ + R +LE L +F + L WL + + + D + ++L
Sbjct: 4751 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4810
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
FQ ++ + V A + A L+E V+ + Q+L T W + L+ ++
Sbjct: 4811 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4870
Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
ALR E V LLE L + E+ + D L + H+ ++L
Sbjct: 4871 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4929
Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
+L + V +C ++ + + AWA + Q+R A
Sbjct: 4930 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 4985
Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
L+A+ A+ + WA D E QE ++ HQ E+ ++
Sbjct: 4986 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5041
Score = 139 bits (349), Expect = 7e-32
Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)
Query: 824 DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
D + + + Q + + + L RL F EL+ + KQ L
Sbjct: 1584 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1643
Query: 884 LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
+ +Q A L + ENFL G+ L E + EQ N +I+ +Q L
Sbjct: 1644 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1696
Query: 944 SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
+ E L + + E + +++ ++ ++ ++L L + S
Sbjct: 1697 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1751
Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
+ K ++ + HF + ++ + E G + GQV T Q L Q ++V
Sbjct: 1752 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809
Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
+ ++ QA TQ+ Q L++ Q L E + Q KE+ V +A L E +
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 1866
Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
++ H QE L++ DA D E + L+ Q QEL+ L
Sbjct: 1867 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 1912
Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
L L+ QK F+ +H+ L ++ G V EA + R+ G+ + T
Sbjct: 1913 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 1964
Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
E R H +S + + + L+ + ++ + S LLA LQ E
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2018
Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
A + + E A +P +N+ + L+ +A + ++ + + VE L++ LL
Sbjct: 2019 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2068
Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
R + DIQ L + ++E L++ + ER ++LQ L R L QD +++
Sbjct: 2069 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2123
Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
G ++SS E GQ +S LQ ++ LE + + + A+
Sbjct: 2124 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2183
Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
S A + A S E + KH L ++ L S +L F L
Sbjct: 2184 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2243
Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
+ V +P T ++ + + S +HK+ ++ + S + +++ G P
Sbjct: 2244 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2291
Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
+ +V E+ L + E+E EA C +Q FQ + V L+ W++E
Sbjct: 2292 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2348
Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
+P + D G+ T +L K E+ +S L +T P
Sbjct: 2349 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2408
Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
+ + + + L++ A + +L
Sbjct: 2409 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2467
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
+L + E+ + WL + A + D E + F+ +++ +
Sbjct: 2468 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2525
Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
V + LLE P +Q ++ + W EL +LT R L ++ L +
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2585
Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ L Q +E S+ ++ D L Q + Q L +E T + E L AG+
Sbjct: 2586 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2644
Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
PG V+++ AVTQ W L ++ R +++A + + ++++ +R +
Sbjct: 2645 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2704
Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
+ + L + S P + +L Q ++ E++ +K + A L + AL+
Sbjct: 2705 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2764
Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
E+ +L + V Q + LQ+ ++ R + + +E
Sbjct: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
K+ + + ++ +E LI+ H+ F K LTAQ E + E L + + ++ + LQ
Sbjct: 2825 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2884
Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
+VKE +L +L + + WI L+E D
Sbjct: 2885 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 2941
Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
+ + K ++ + E+ H ++ + +LL+ V+ + L + + +
Sbjct: 2942 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001
Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
+ + + LE+ + F EF + ++ +Q + ++++ D LG
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
Q L+H + L +RL + A D+ G SD+ LQ V+ I Q S
Sbjct: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3107
Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
L+ QQ E + + + + I +E Q + +L+S+
Sbjct: 3108 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3152
Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
+ R E L+++ I+A ++ LE + C + SP+ G++ +
Sbjct: 3153 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3211
Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
+++ +L RAQ R E ++ + + ++ + L+E + Q+ ++ E
Sbjct: 3212 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
M + Q K E++ GQ L+ + +S GLE +L +
Sbjct: 3272 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3324
Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
W+ + QLQ+A L F ++E + W+ E+ +A++ P A + +
Sbjct: 3325 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3382
Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
+ + K+L+ L+ + + ++ + P + L + + R EAL +
Sbjct: 3383 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3442
Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
A TR +LE + + Q F + + + WL EK LV E + L Q+ + + +
Sbjct: 3443 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3502
Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
+ ++ + H Q + + + +Q +L+ + E+Q+ S + LQ+A
Sbjct: 3503 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3562
Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
C A EL NWL + +L +V + G+ + R L+ + + + +
Sbjct: 3563 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3622
Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
QA + L Q ++ +Q++ A++AR ++D
Sbjct: 3623 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3657
Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
KL A+ Q+L R L H+ L E E+ S+E T+V+ G
Sbjct: 3658 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3706
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
E A++ Q K L+ EA + LL E L EL+ W A
Sbjct: 3707 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3749
Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
G + +ED + + +++E +++A R ++ Q A
Sbjct: 3750 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3792
Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
A+L + E +L+ + R Q QL + T+ + +D D
Sbjct: 3793 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3841
Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
L VK + A +E + + K+ + K T+ + RY ++ +S + WE
Sbjct: 3842 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3899
Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
++ TE Q ++L E ++R Q++HR+
Sbjct: 3900 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 3936
Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
L + + + ++ +L +L P + + A TL ++ +E +
Sbjct: 3937 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3996
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
++Q+ Q H + + E L ER L ++ +V ++ + +++ + ++ + +
Sbjct: 3997 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4054
Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
+ L+Q G++++ S +++ + ++ +L ++ W
Sbjct: 4055 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4093
Score = 136 bits (342), Expect = 4e-31
Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)
Query: 469 VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
VA RQ+E + Q + L Q + + + +A + VE +Q EELQ+ + +A
Sbjct: 1592 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1651
Query: 526 CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
Q LAEVV E L + D L EA++ ++ Q ELD
Sbjct: 1652 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1708
Query: 568 LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
+ T+++ K + QL++S + + ++EQ Q
Sbjct: 1709 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1768
Query: 608 EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
+ EE+ + + +G + QK KA E + +HQAV +
Sbjct: 1769 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1828
Query: 667 GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
L + P+ E+ + ++ + + LQ + AD E
Sbjct: 1829 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 1888
Query: 722 AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
WL++ LE G D T L+R + + +LR + G A
Sbjct: 1889 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 1948
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
SC G + D + + DH +
Sbjct: 1949 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 1976
Query: 841 QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
+ SL + + L++ + + +SCG L
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2036
Query: 874 QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
Q LE+ L ++ Q +E ++ E L A ++ + + + RY S
Sbjct: 2037 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2096
Query: 934 TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
+ + E+L + L S+ V L E + L + +
Sbjct: 2097 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142
Query: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
S+ ALQ K ++LE+ + QS + + E + +LQ +K +
Sbjct: 2143 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197
Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
+ ++ + + ET A+ L+ +L +E +Q L +K EV V L
Sbjct: 2198 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2257
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
+ Q+ E ++ L+ L + + ++ S +P+ ++ ++ L +++ +
Sbjct: 2258 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2311
Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
++E E + ++D F + ++W+ ++LG+ + + L
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2371
Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
+Q+ G L+S + A+A+ A G ++ + A +T
Sbjct: 2372 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2431
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
+ L SI+ T + E L +A L +LQ+ +++ + +MQW+++ A
Sbjct: 2432 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2491
Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
P+ ++T ++++++ E+EL V+ L+ ELL P E + +
Sbjct: 2492 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2551
Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
L + SKW+ LN+ +R +L+++ L Q Q + QL+Q +E L S G
Sbjct: 2552 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2608
Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
L + QQ++ E T + L + G+ + P + E+
Sbjct: 2609 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668
Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
++ + L G L+ R + QA V+ Q+ L S+++ + P + +
Sbjct: 2669 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2728
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
L AQ + ++ ++ + ++K Q + + L L A Q + I++ Q+
Sbjct: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2788
Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
E H L+ AC + Q Q + FQ + LD + E + K ++ S +D+
Sbjct: 2789 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847
Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
+ A + K A E L + E+ Q T +V E++ ++E
Sbjct: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2907
Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
L + L+ L+E+ D E E ++ +L +E + G +
Sbjct: 2908 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967
Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
A S+ E D E H+ C KF +FQ +V
Sbjct: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3026
Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
S+R C A+ L+ S G M++ +Q+ LQ A +
Sbjct: 3027 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3083
Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
E + ++G L ET + H L + QV EK + L N R++
Sbjct: 3084 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3140
Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
+ +L S + R+ ++Q L+ L+ + K C P
Sbjct: 3141 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3200
Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
+++ +A+++ L R + R Q+E + L F + +++++ + Q +
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3256
Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
E SQ P + Q + + E+E + Q LGQ + +A T
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3311
Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
+ L+ D V W +++ Q Q Q L CGR ++ L + +E+
Sbjct: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371
Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
+ + V+ I++ ++ ++L + ++ E++ T P ++ +L +
Sbjct: 3372 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3431
Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
L R + AE+R L S++ F + +W+ ++L P G KL
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3491
Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
+ + +H+A E ++ H + + G++L S ++ Q + W
Sbjct: 3492 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551
Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
E L+QA+ ED + +L V +K K++V D + Q
Sbjct: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3604
Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
R+ + V A + + LK +EV II + + R+
Sbjct: 3605 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660
Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
+ LE AL+ +H EL ++ E E L K E+ Q +R +E
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3718
Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
L++E +A ++SL L + P A GL E E + + ++ E +D
Sbjct: 3719 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
A L Q QA EL + + M + L+ + E+ D
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
I +G +++TA +++ L + + ++ E LQL++A L F
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
+ E++ WL + ++ L P E L +H+ L + I + T
Sbjct: 3899 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3956
Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
L + E S + A + R L+E ++ L+ +
Sbjct: 3957 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016
Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
+ LR+ ++ E + Q+ + +N +++ + L++ G+ ++ G
Sbjct: 4017 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4071
Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
G +++A+Q++L+++ +W + +++ AKL C+ + L ++++
Sbjct: 4072 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4131
Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
++++ +E P+V + E + G Q EL+ ++ + A G+ +
Sbjct: 4132 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4190
Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
V++ L + SL + ++R L EA +++ WV
Sbjct: 4191 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4241
Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
LA+ G L V+ E+ Q +E E +H+A L + V K
Sbjct: 4242 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4298
Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
H V + +L+ L R+ L+ A A QF L E +WL G
Sbjct: 4299 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4352
Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
+ + + +G +A + L + + D+ A +E + + L+ES E+ +
Sbjct: 4353 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412
Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
+L+ + + +L + E R HG E LQ + E LL +
Sbjct: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4472
Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
+ +E E K + ++ +Q GQ + K A T +I
Sbjct: 4473 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4521
Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
+ ++ WE ++ + R E L A E H+ Q + Q + L
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4579
Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
L +V +H+ E+ + +++ L L L K VQ W
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
+ + ERG+ L A + F +L+ W +E ++ SE E+A D + L
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
QH+E + + + G+ L + + + +L+ L EL + W
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4749
Score = 132 bits (331), Expect = 8e-30
Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)
Query: 306 MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
+ Q L F +F+ +E P ++ L L + L H+ L +++ W
Sbjct: 3271 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3327
Query: 366 AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
L A R+ LQ+ LL RFQ S++ D E+++ + P A
Sbjct: 3328 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380
Query: 426 TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
V+A +Q +L+ ++ +EG + AE AD ++ + ++
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3431
Query: 476 VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
+ RW+ LL + + +Q+ + V E +E + L +++ R C G Q +
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3489
Query: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
++ E + +H LE + H H+ S+G S++VL + K ++L S
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3541
Query: 589 LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
V + +R LL+Q L A+ E E WL E ++ ++ ++
Sbjct: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601
Query: 642 ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
Q + L+ ++ + + G +L + G+ +Q + ++
Sbjct: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3651
Query: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
AR + + A E A L R S C LL ++ +
Sbjct: 3652 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3708
Query: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
A A++R E + A + +A L ++N S E + W+
Sbjct: 3709 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3751
Query: 821 AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
E D D ++Q E + A A LR + ++A + EL W+
Sbjct: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3801
Query: 878 EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
EK+ + L ++ + D + F + K + ++ S ++ Q +
Sbjct: 3802 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3861
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
+++ +++ + + + + E+ +QL + + + +E P + + ++ QL A
Sbjct: 3862 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 3919
Query: 993 PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
P +T Q Q + L+ E + H + ++ E E +Q + L
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3979
Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
Q++E V +RA E ++ + F + Q+L E + +LR +S +V + +
Sbjct: 3980 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4039
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
E++++ ++ Q + L + + M A +++ + + + + ++ +WE
Sbjct: 4040 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4097
Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
+R+ L + +EL +KF + T + Q ++ L++ G E
Sbjct: 4098 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157
Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
+RE + LQ+ + ++ LG +E + A GE P V++ + + + W L
Sbjct: 4158 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4205
Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
+ R +L ++Q QD + + W++ G +A+ P G + Q ++ +
Sbjct: 4206 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4265
Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
+SE + +E L ELL ++ + D +Q L L+ W++L ++ R
Sbjct: 4266 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4324
Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
+L+ A GQ + L +L L EG L + G D ++ + +H L+++
Sbjct: 4325 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
+ + A+ + + S A EE +LE+L R QL ++
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
+ H +L W+ + H G P + E LN H E+ +A
Sbjct: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4493
Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
+ + ++ G+ + A A+ ++Q L+ W +E R L++A+
Sbjct: 4494 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553
Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
F + + + W+ + V+SR + + I++H+ E+ + + ELD+T
Sbjct: 4554 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4612
Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
L ++Q VV Q R + ++ L E + D + + HE +
Sbjct: 4613 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4669
Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
L WL +++ + DP+ + +FQ + SL E
Sbjct: 4670 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727
Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
+ A ++ +L+ W + + R + L + D L+ L
Sbjct: 4728 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4787
Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
E + V D+ + + +H+ ++EL +Q L +A ++L G + +
Sbjct: 4788 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4844
Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
V+ + Q ++ W + ++ +LE A R F + V W A Q L+
Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4904
Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
+ L H+ +LE + +AT +G L + + +
Sbjct: 4905 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
R + WA++ ++ A L ++ LE +LA + + T + +EEV
Sbjct: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5023
Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
+ LI +H+ F++ +T +K+ + + KT +R R D P LQ + V + +
Sbjct: 5024 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5077
Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
AS L S +Q + ++ W Q W L+ D D+L+ L + F+
Sbjct: 5078 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5137
Query: 2161 AEV 2163
++
Sbjct: 5138 FDI 5140
Score = 110 bits (275), Expect = 3e-23
Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)
Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
++ L Q +T ++ + V +L WV+E + + ++G D + + H+ + +
Sbjct: 630 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
+ SS++E + +T P ++ +++ RL Q L + ++R L+ LH F
Sbjct: 690 EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 744
Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
+ A + WL ++K+ + E + A+ +++ + + + + +AE
Sbjct: 745 VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 803
Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
LL H A + + +QT WS + +L Q +++ D E ++
Sbjct: 804 QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 863
Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
++ + C + + + L +E + + +ELL+ + L
Sbjct: 864 LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 907
Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
+ +A ++Q + L+ + + A+ DY Q+E + +
Sbjct: 908 -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 948
Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
L ++H RA+ W+ + G +A++ P KE + ++ Q
Sbjct: 949 DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 998
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
V W +++ + E ++ I A+ S+KT G + + L +
Sbjct: 999 YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1055
Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
E FL +D +E+ + + + + Q ++ E E +L
Sbjct: 1056 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1108
Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
++ + E+ +Q++ P+ DL + + + + + + E++ ++ + ++
Sbjct: 1109 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1168
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
K E +Q+ + + R + L +++ Q ++ ++ + L+ AEA
Sbjct: 1169 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1227
Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
++ E K+ N+ +L L+ Q R + E R ++ D + A ++I
Sbjct: 1228 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1282
Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
SD + + ++ QL RW + H Q++ L
Sbjct: 1283 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1322
Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
+DLE + + L+ + + HP+ ++ +E ++ + PE
Sbjct: 1323 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1363
Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
+ L + QQ++ S +++ QK E A + +LQ M +V +Q+
Sbjct: 1364 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1420
Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
+SPV+ RRM E +D T +L Q + AG
Sbjct: 1421 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1464
Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
L LE+E SLE +EH +++A ELQ ++S++ K ++ + S+E
Sbjct: 1465 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1521
Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
S E L + L ++ L KH KM + + ++ L+ + L + Q +
Sbjct: 1522 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1581
Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
+ K RQ + E+L+ + L + E L+ +E +
Sbjct: 1582 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1629
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
T L KQ+ Q ++ S E+ + + L + G S+ I+++L E
Sbjct: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689
Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
+L + S+K++ K+ +K +L S ++EN WL ++ + R
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749
Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
A T +G+ G LL TQ L K
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809
Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
Q E ++ Q QA + ++G L+ + +E+ ++ ++ K +L E ++
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869
Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
+ + L KF D E W+Q+ + L + ++ + ++ ++ ++ S
Sbjct: 1870 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929
Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
H+ R + +G ++++A + +V ++L+ A R+ ++ +L
Sbjct: 1930 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1989
Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
++ +A L ++ H +E + L R+LE TK
Sbjct: 1990 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2049
Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
+ + +E+L++TA LL++R + P + L + + +L + R LQ
Sbjct: 2050 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2109
Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
L ++ L +LD W+ ++ + Q QD+ ++ E+ A R
Sbjct: 2110 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2164
Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
Q+ + A+ K+ +E P +QA+ + A R +A E LA E
Sbjct: 2165 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2218
Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
V F+ + +LQ ++ KT AL + + G ++ + Q +H++ L
Sbjct: 2219 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2278
Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
++ KE++ P A V E L K +E + + +
Sbjct: 2279 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2326
Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
AF + L +W +E + + GAE L E+ + + L+ +++
Sbjct: 2327 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2383
Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
+ + + +SA T + EG EE WA + GL
Sbjct: 2384 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2435
Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
+++ + D H D+ LLL + L KL AQEE A
Sbjct: 2436 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479
Query: 3444 MQ 3445
MQ
Sbjct: 2480 MQ 2481
Score = 108 bits (270), Expect = 1e-22
Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)
Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
+VAS + +L EHQ +L + Q R + SQ D ++ + V Q Q
Sbjct: 1033 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1089
Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
EL E+ +Q E + EV N + L D+L E V
Sbjct: 1090 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1146
Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
+ +E RL LG + S + T+R +L + ++ S
Sbjct: 1147 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1204
Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+L ++ L AE + + E L + NI + + SE+
Sbjct: 1205 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1263
Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
R+ AL+ EL + E +T + L +W+ ++ ++
Sbjct: 1264 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1320
Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
R +L+ G+ + R L D +Q+E + +Q ++ + +L ++ + L S
Sbjct: 1321 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1379
Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
E +KM A +A+ E R + Q ++ ++Q+S +L +
Sbjct: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1439
Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
F L + V T Y + + + L + K L+ E K H Q V
Sbjct: 1440 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1493
Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
+ + + +G P +E+ +L A + T Q +
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1538
Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
L D DE L + + LQE + +S E L Q ++ T +
Sbjct: 1539 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1584
Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
V ++++V ER +E LQ L T +R + +GT+ L ++ + E+LQ
Sbjct: 1585 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644
Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
+ QA + GE L ++ + + AK + +
Sbjct: 1645 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1704
Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
++ +++VAA + L ES + + + +D + A ++ ++ + G
Sbjct: 1705 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1763
Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
++ + V+ +LLE T V + + N+ + ++AQ + +
Sbjct: 1764 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1821
Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
+ + Q LLE G Q L P + + ++ L ++ + L
Sbjct: 1822 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1879
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
+F ++ W + Q+L+ E+ + +G + KL + ++ + + + T
Sbjct: 1880 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1939
Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
G + L AA + +K EVQ +L D+ +Y L+ ++
Sbjct: 1940 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1999
Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
+ CG L + A + + K + +V+ + L R+ E K L Q +
Sbjct: 2000 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2057
Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
E+LK + R +L +Q+ + R ++L++S R L +L + S
Sbjct: 2058 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
+ DW+ LKE P+ L+D + K+ E ++ + + ++ +K
Sbjct: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2174
Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
+ + + P A + +++ L + + ++E+ + +E + + + +
Sbjct: 2175 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
+++ K + D+ G+D+ Q ++ EF + V + ++ IS L
Sbjct: 2235 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2289
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
P + ++ ++ + L+ ++ + ++ + E VL + L + K +K
Sbjct: 2290 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2348
Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
++Q A D GK LE ++L K E+ + SL + + + A
Sbjct: 2349 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2408
Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
G + A E +W L+ + + L
Sbjct: 2409 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2468
Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
L +AQ+ + + + L + + +PAP + +E+++ +AEL + +
Sbjct: 2469 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2528
Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
+ +LL R +Q L+ ++ WQE +QL + QQ LE L
Sbjct: 2529 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2583
Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
F + ++++WL KE ++ G PL+ +L + ++L + + + L
Sbjct: 2584 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640
Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
A +G+ G P + + A + +K ++L Q R +++ Q Q+ L+
Sbjct: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700
Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
+ + L K +L AM QL+ Q + E+ Q Q L +
Sbjct: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2759
Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
L++ + +E + +LE + + +++ ++ V LQ AC + + ++ + + WL+
Sbjct: 2760 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2818
Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
E + ++ + L + L+ ++ + ++ E + + + ++
Sbjct: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2878
Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
++ Q + + + + ++ER L E+ LK+ + W+ Q L +
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938
Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
D + +++ L ++L+ EM H + ++ T L+ V + L
Sbjct: 2939 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 2994
Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
+ + + + ++ L+ Q+ ++F E+ L LD D S +
Sbjct: 2995 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3054
Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
L L+ ++ L+A +++ ++ A ++E+ + + VL Q++ + + H+ L ++ +
Sbjct: 3055 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3114
Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
+ L+ +LQ + ++ + D L + A G+D E ++ +E
Sbjct: 3115 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3168
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
AF K++++L + A + L P + + +EA + Q K
Sbjct: 3169 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3223
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
A +V + E +++E + L+ K E+ S V T+ QQ +
Sbjct: 3224 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3283
Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
E+E ++ + Q + LGQ + AA L V W TL K +R
Sbjct: 3284 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3339
Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
L +A F + LL+W + +EL ++++ + Q ++L Q + + R
Sbjct: 3340 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3399
Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
+ +++EG+++ + ++ + L L+ R + L +A Q S Q+
Sbjct: 3400 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459
Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
+ LE WL E L+ + G S +E + +H+ LE
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3519
Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
K+L+++E+K K + Q ++ QE R+
Sbjct: 3520 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556
Score = 93.2 bits (230), Expect = 4e-18
Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)
Query: 246 CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
CS + Q+++++L K+L LQL+ + L Q+ + +L W+ E Q
Sbjct: 3853 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3911
Query: 292 MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
+ LPA L T+ + QE+ +L++ L+ + + N+
Sbjct: 3912 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 3957
Query: 349 --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
P EG + E + + + + +++R + L + + +F K +
Sbjct: 3958 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4011
Query: 407 LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
L+ E+++++ R PP+ A VE +++ + + E + Q L E +E
Sbjct: 4012 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4070
Query: 465 -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
S V + +++ W+ + ++ + ++ D+ + +SL+ ++
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4130
Query: 510 ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
+ +L++P + +Q E E ++ D L+ ++ S L E D
Sbjct: 4131 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4189
Query: 569 GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
+++ L SL + R LE+ +Q A ++ + W+ G ++
Sbjct: 4190 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4244
Query: 628 GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
+ + +G DL + +++ K ++E ++ Q + ++ + +L ++ + D +
Sbjct: 4245 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4303
Query: 687 AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
+ W L+ R++ R +L+ ALL L F A E +WL L E+ G D
Sbjct: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363
Query: 742 QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
A E L +H L+ + A + + A++ G L
Sbjct: 4364 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4403
Query: 802 WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
EAS + + L+Q ++++ + R+ +L+ A+
Sbjct: 4404 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
Query: 862 -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
GF +LQ WL E+ + + + +T + + A + +
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4499
Query: 918 VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
+ +Q+ R P ++ T I + L ++W +E E+ +L E + E
Sbjct: 4500 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4556
Query: 977 TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
+ + L Q E A +P DT Q+ + K E H + ++++++ G
Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4613
Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
+++ Q ++ + ++Q ++V +++ +R R + + R + F + +L+ W
Sbjct: 4614 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4673
Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
E + L S+ E++ D + L +H++ + + H + + + +L
Sbjct: 4674 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4732
Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
D+ ++ + L L + + +RQ L+E L G+ D A WL+
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4786
Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
L E D+ ++L+ H+ F + L +AL+ +L++ + V
Sbjct: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4846
Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
+ Q+Q + +W + S ++ +L A+L Q +E+ V L++W+ E + + H
Sbjct: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4906
Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
+ L+TL +H+ +L R + +G +L+ C + I T W
Sbjct: 4907 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 4959
Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
+ R E + L A Q +Q L L +E LE L LQ +ET + + +
Sbjct: 4960 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017
Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
Q++E +A + M P + + T+ + RR LQ H+ +
Sbjct: 5018 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5067
Score = 58.5 bits (140), Expect = 1e-07
Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)
Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
Q ++E ++ +QD +++++ L +E G DL S + + H+ + E ES
Sbjct: 636 QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 695
Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
AK++ + A P L +K L RLE L + ++ LH F +
Sbjct: 696 KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 748
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
EL W+ E ++E H EL E+ + ++ V L
Sbjct: 749 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 808
Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
HP I ++ W+ + + C+ Q +++ + ++F D E ++ + +
Sbjct: 809 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 868
Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
R Y D ++++ L+ + +EEL Y S++ L A+T+
Sbjct: 869 -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 914
Score = 57.0 bits (136), Expect = 3e-07
Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)
Query: 209 VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
V E + + +LL+ P + ++T + + ++L T+ R+ +L+E
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2576
Query: 269 TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
+ TQ++ + A L +W+ EK++ + P+ L RQ + KP
Sbjct: 2577 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2636
Query: 325 LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
Q A + +L R + + R + + LA ++Q W L + R + Q ++
Sbjct: 2637 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
Query: 385 QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
+ + ++L R K + ++ L + V A L T + Q + + I
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750
Query: 445 EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
QAL E L +E+Y A+++R+ E + ++ + Q + + L
Sbjct: 2751 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2795
Query: 505 QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
Q A+SHQ +++ +E +S +L + L++ H ++A
Sbjct: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2853
Query: 553 HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
SH+ ++T +L G+ LQ + T+ + V+ R L+++L++A
Sbjct: 2854 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
Query: 608 -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
++ E W+ +C + D ++ ++ K K+L+ E+ +H
Sbjct: 2912 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 2961
Score = 40.4 bits (93), Expect = 0.032
Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)
Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
+L + E + + G L SV + + H+ + R +E E + + ++ ++
Sbjct: 650 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 704
Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
AP L +++ +A L ++ + + L H F+ R L W E++E
Sbjct: 705 MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 761
Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
+ + +E + H EL +E+ + + +++ +QL+ +H A +T
Sbjct: 762 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 815
Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
+E ++ W+ Q C Q + Q +++ A+ + DY ++ D
Sbjct: 816 -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 867
Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
+ R ++ ++ K + + ME+ E LLQ + G + T Q +P
Sbjct: 868 --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 919
Score = 40.0 bits (92), Expect = 0.042
Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)
Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
Q LL W + +Q QL E D+ S + L H+++ I ++ L++ M A
Sbjct: 649 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 707
Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
P L L + Q K+L R Q ++ + F + N WL
Sbjct: 708 --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 755
Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
+ + + D E + + + H E R L ++++ E+L+ HPA T
Sbjct: 756 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 815
Query: 1250 VREQLQSIQAQWT 1262
+ ++Q QW+
Sbjct: 816 IEAYRAAMQTQWS 828
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 222 bits (566), Expect = 5e-57
Identities = 592/3111 (19%), Positives = 1250/3111 (40%), Gaps = 297/3111 (9%)
Query: 408 KDAEQVLDQARAPPASLATVEAAVQRLG-----MLEA--GILPQEGRFQALAEIADILRQ 460
K+ ++ L++ +A +++ + AV++L +L+A +LP + Q + DI+ +
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD--DIVGR 2229
Query: 461 EQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEP 520
+ S V R E++ + R L G + + M V S L+E + Q P
Sbjct: 2230 YEDLS-KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE---------QGQVP 2279
Query: 521 ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKA 579
STA + +++ ++ +LE ++ + ++ + ++ + ++++ ++ LQAK
Sbjct: 2280 LNSTA-------LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM 2332
Query: 580 RTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE-EAWLKECGQRVGNAAL-GRDLS 637
+ L+ + A +E+ + E N E+ + +L+ Q + + G+D++
Sbjct: 2333 KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT 2392
Query: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-ERAEAVQGGWQLLQ 696
+++ +Q+ + E +H V L++ ++S+ P+ E+ + ++ ++
Sbjct: 2393 ELSQYMQESTSEFLEHKKHLEVLHSLLK---EISSHGLPSDKALVLEKTNNLSKKFKEME 2449
Query: 697 TRVVGRGARLQTALLVLQYFADAAEAA-SWLRERRSSLERASCGQDQAAAETL---LRRH 752
+ + + + L F ++ SW++E + ++ Q AE L L
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE---TTKKVPIVQPSFGAEDLGKSLEDT 2506
Query: 753 VRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPG 812
+L+ E++++ G SL + SA++ P +++ S + G G
Sbjct: 2507 KKLQEKWSLKTPEIQKVNNSG------ISLCNLISAVTTPAKAIA--AVKSGGAVLNGEG 2558
Query: 813 DAWKMALPAEPDPDFDPN----TILQTQDHLSQDYESLRALAQLRRARLEEAMA-LFGFC 867
A +F N +I + +S YE L L + + A L ++ L
Sbjct: 2559 TATNTE-------EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2611
Query: 868 SSCGELQLWLEKQTVLLQRVQ--PQADTLEVMQLKYE---NFLTALAVGKGLWAEVSSSA 922
+ WL+K + Q P E ++ + E +F L E+
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2671
Query: 923 EQLRQRYPGNSTQIQRQQ--EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
+L + P + +Q E+ +W +L L ++ +L S + L + + Q
Sbjct: 2672 TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQ 2728
Query: 981 LRDVLLQLE----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQ 1036
L+ L++ E L P S + Q Q + L+ E Q + G S+
Sbjct: 2729 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SR 2787
Query: 1037 PLQGQVETLQGLLKQVQEQVAQR-ARRQAETQARQSFLQES-------QQLLLWAESVQA 1088
P G+ +L+G++K+ V Q+ + R ++ ++ Q LL +
Sbjct: 2788 P--GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2845
Query: 1089 QLRSK-----EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD--S 1141
L +K VS + + L Q + +EI +++++ A + ++AL +
Sbjct: 2846 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2905
Query: 1142 QEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCANHQAWLH 1197
E+ L + + ++++ E Q LQ + Q+ R+ + T Q H
Sbjct: 2906 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2965
Query: 1198 LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV-QSQHPAAHTVREQLQS 1256
+ DV E SL++ H++F + L+ E A GE L+ ++Q ++ QL +
Sbjct: 2966 PISAKLDVLE--SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 3023
Query: 1257 IQAQWTRLQGRSEQRRRQLLASLQLQ-EWKQDVAELMQWMEE-----KGLMAAHEPSGAR 1310
I+ W + ++R +L SL+ ++K+ V L W+++ + + +P+
Sbjct: 3024 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE 3083
Query: 1311 RNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALN 1370
+I + ++ + E+ VE L LLS +E + + L K + +
Sbjct: 3084 NSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3139
Query: 1371 RK----------MTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
+ MT++ E Q+ ++ + RQLQ AKEQL+ + + + + L Q
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESK--RQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3197
Query: 1421 RLQKRHQQLESE---SRTLAAKMAALASMAHGMAASPAILE-ET--QKHLRRLELLQGHL 1474
QK Q L+ + ++ LA + AS + G S +L+ ET Q+H + +
Sbjct: 3198 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--TSDVLLQVETIAQEHSTLSQQVDEKC 3255
Query: 1475 AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEV 1534
+ +LQ + + + + +P A++L +K KE +
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG-----RDAETL-QKQKET---I 3306
Query: 1535 KAHQGQVQRVLSSG-------RSLAASGHPQA---------QHIVEQCQELEGHWAELER 1578
KA +++ +++S + + A+ + + +QC +L E
Sbjct: 3307 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3366
Query: 1579 ACEARAQCLQQAVT-FQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA-- 1635
E + L++ + +++ + + + E E + P+ + + ++ K +
Sbjct: 3367 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3426
Query: 1636 LQ-EELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDREL-EG 1693
LQ ++ + W + L Q+A T + E + + + + L + A R +L E
Sbjct: 3427 LQGKQQDVNWLG-QGLIQSAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEA 3482
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
L F E L W+ ++ + P A K K Q Q + QR+
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVAN-----QKPPSAEF---KVVKAQIQEQKLLQRLL 3534
Query: 1754 ACRLLAESLLER-----GHSAGPM----VRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
R +++R +A P + ++ L + W L + R L
Sbjct: 3535 DDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3594
Query: 1805 LRVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
+ + LE L + EK + LE Q+ H+ LE +++ + L + +
Sbjct: 3595 AQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV 3654
Query: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAV-LQRRMEQRRAQLERARLLAR-FRTAVRD 1919
+ G+ K+ + + Q + +Q W + +Q + R L++A A+ F +
Sbjct: 3655 -SIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3713
Query: 1920 YASWAARVRQDLQVEESSQEPSSGPLKLSAH-QWLRAELEAREKLWQQATQLGQQALL-A 1977
+W V L + G K + + L+ ++ R++ QA G + L
Sbjct: 3714 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773
Query: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRE-----CGRLE----E 2028
G +Q++L A++ + + + + L+ Q L C L+ E
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833
Query: 2029 ILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDR 2088
+L+ + LK + ++L ++ + +L + ++ +AL E + R +
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893
Query: 2089 LPILLQRRMRVKELAESRGHALHASLLMAS-FTQAATQAEDWIQAWAQQLKEPVPPGDLR 2147
+ +R V + + + A++L + F QAA WI ++L + GD+R
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL---MSLGDIR 3950
Query: 2148 ---DKLKPLLKHQ-AFEAEVQAHEEVMTSVAKKGEALL-AQSHPRAGEVSQRLQGLRKHW 2202
D+ L+ Q F E+ H++++ + K G ++ A S + ++L + K++
Sbjct: 3951 LEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 4010
Query: 2203 EDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEV--------KMNVGDLGQDLE 2253
+ + Q + R +LE ++ + +F + + W+ E + + L Q E
Sbjct: 4011 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQE 4070
Query: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
QLR + E + + I ++ QL P E I ++ + ++
Sbjct: 4071 EHRQLRELIAEHKPH----------IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 4120
Query: 2314 FHGNLLRYQQQLEGALEIHVLSRE-LDNVTKRIQE-KEALIQALDCGKDLESVQRLLRKH 2371
++ + L+ A+ + +D + + ++ E L Q ++E ++ + ++
Sbjct: 4121 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180
Query: 2372 EELEREVHPIQAQVESLEREVGRLCQRSPE-----AAHGLRHRQQEVAESWWQLRSRAQK 2426
+ + ++ +Q E+L++ + RS +A ++ + ++ W + + ++
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4240
Query: 2427 RR-EALDALHQAQKLQAMLQELLVSAQRLRAQM-DTSPAPRSPVEARRMLEEHQECKAEL 2484
R + LD + A+K L+V+ + + + D P ++ E + + E+
Sbjct: 4241 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4300
Query: 2485 DSWTDSISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL 2543
D + + + + G +L+ A G P +++ + L SL AW++ +L++A++
Sbjct: 4301 DGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4360
Query: 2544 QL-FLSSVEKMERWLCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
+ + ++ + W+ LAS + L ++ + + K + + Q ++ L
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420
Query: 2602 ATARGLHQGGHPEAQSALGRCQAMLLRK--EALFRQAGTRRHRLE-ELRQLQAFLQDSQE 2658
A L + E+ + M L+ ++L + R+H+LE L L F E
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480
Query: 2659 VAAWLREKNLVALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG- 2715
+ AWL + E+ + D + +L K Q ++ A + + + G L++
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540
Query: 2716 -GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLEPIEV 2773
G AS +Q +LE L W + + ++++ +L A +A +E+L+ WL E
Sbjct: 4541 AGEEASN-LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599
Query: 2774 ELRAPTVGQALPGVG-ELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQ-DVEE 2831
L A LP E L E+ AA + K ++L+ + Q + A+ ++++
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659
Query: 2832 QARRLLQRFKSLREPLQERRTALE-ARSLLLKFFRDADEEMAWV-QEKLPLAAAQDYGQS 2889
L ++++S+ L ER+T LE A +L ++F + + W+ Q + L A
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719
Query: 2890 LSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL------- 2942
L V ++H+ +E++SH + TG L +F+ + ++ L
Sbjct: 4720 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK---YFSQKQDVVLIKNLLISVQSR 4776
Query: 2943 -EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSE-DMGHSAEATQ 3000
EK + L R R L + A+QF + WL E LDSE ++ + + +
Sbjct: 4777 WEKVVQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4833
Query: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PESPKVLAQLQAVREAHAELLRR 3058
L + + ++ L A + +T L+ + + ++ K+ L +R+ + +
Sbjct: 4834 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893
Query: 3059 AEARGHGLQEQLQLHQLERETL--LLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR 3116
+ R + L+E L + L L+D + AE Q D++ V L + AF+
Sbjct: 4894 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQ 4953
Query: 3117 KEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAA 3176
KE+ + V AL++ A L G+ ++ Q + WE + ++ L AA
Sbjct: 4954 KELGKR-TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 5012
Query: 3177 HE--------VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEA 3228
VH+ + AE + ++ L ED ++RTL QH+ ++LE
Sbjct: 5013 LRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDED------ALRTLIDQHKEFMKKLEE 5066
Query: 3229 MEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ----AAQGHAF 3284
E+ + T + L P + ++ ++A+ +E W Q A A
Sbjct: 5067 KRAELNKATTMGDTV--LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 5124
Query: 3285 LGRCQEL-------LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEI 3328
L QEL L WA+ E + +++ + L+ +H+ +E+
Sbjct: 5125 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175
Score = 209 bits (531), Expect = 5e-53
Identities = 191/673 (28%), Positives = 306/673 (45%), Gaps = 97/673 (14%)
Query: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
++Q+KTFTKWIN + + +LY +L DG +L+ LLE++SG+ LP +GR+R H
Sbjct: 213 KVQKKTFTKWINQHLM--KVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFH 269
Query: 79 FLENSSRALAFL-RAKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
L+N AL +L R +V + I ++I DG+ L LGLIW IIL FQIS I + E
Sbjct: 270 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 329
Query: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
SA KE LL+W Q+ T Y + +F+ W DG FNA+IH +RPDL+D ++
Sbjct: 330 SA-----KERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 384
Query: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
L NL AF VAE ++G+ +LLDPEDV + PDE+S++TYVS Y ++ +G
Sbjct: 385 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEG-- 441
Query: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
+ + E+ +Y+ +V L++WI + R FP++ ++ L + F+
Sbjct: 442 ------IGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 495
Query: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
E PP+ ++ + L L+ ++ + +G ++ + W L A R +
Sbjct: 496 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREK 552
Query: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
AL+ + +L+ L+ +A R Q + + E L A L L
Sbjct: 553 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK----------------RL 596
Query: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
E+G+ +FQ AEIA + + + RQ + V Q L+ Q Q+ +
Sbjct: 597 ESGV-----QFQNEAEIAGYILE------CENLLRQHVIDV--QILIDGKYYQADQL--V 641
Query: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
Q V L E+ A ++ + R Q + + Q + AQ + H + S L
Sbjct: 642 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ-TLHPSLTSGL 700
Query: 558 AQQ-TAELDSSLGTS---------------------------------VEVLQAKARTLA 583
Q T L SS TS VE + L
Sbjct: 701 TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLM 760
Query: 584 QLQQSLVALVRARRALLEQTLQRAEF-LRNCEEEEAWLKECGQRVGNAALGRDLSQIAGA 642
Q+++ L+ + +LL+Q L E ++ ++ W+ E ++ G DL +
Sbjct: 761 QIRKPLL-----KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESH 815
Query: 643 LQKHKALEAEVHR 655
L+ HK VHR
Sbjct: 816 LENHK----NVHR 824
Score = 203 bits (516), Expect = 3e-51
Identities = 447/2315 (19%), Positives = 937/2315 (40%), Gaps = 235/2315 (10%)
Query: 872 ELQLWLEKQTVLLQRVQP---QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQR 928
+ Q WL+ + + P + D LE + +++F L ++ + + E L +
Sbjct: 2949 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK 3008
Query: 929 YPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPT--------QV 979
G+ +Q Q + W +E+ +L S+E +E T Q
Sbjct: 3009 TQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQN 3068
Query: 980 QLRDVLLQLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEEPGY 1032
L ++ L P E++ L+ QK+ +L + L SV +E
Sbjct: 3069 NLEEIKF---CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 3125
Query: 1033 AESQPLQGQVET-----------LQGLLKQVQE--QVAQRARRQAETQARQSFLQESQQL 1079
E++ L +V+ L+ + ++ +E +V++ ++RQ + Q + +S
Sbjct: 3126 DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3185
Query: 1080 LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCP 1139
++ L++++ S+ L+ DL + + AQ + A D
Sbjct: 3186 QAYSNKYLTMLQTQQKSLQA------LKHQVDLAKRL-----------AQDLVVEASDSK 3228
Query: 1140 DSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLE-LQKFGREVDGFTATCANHQAWLHL 1198
+ +V + + Q+ L +++ +L+ L+ + F + + A L
Sbjct: 3229 GTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD--EL 3286
Query: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKL---------VQSQHPAAHT 1249
D++ R+A +L +Q L L EAL A + + P
Sbjct: 3287 DSMAPVGRDAETLQKQKETIKAFLKKL----EALMASNDNANKTCKMMLATEETSPDLVG 3342
Query: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQ-LQEWKQDVAE---LMQWMEEKGLMAAHE 1305
++ L+++ Q +L R++ R Q+ +++ L+E+ + E L+Q EE +
Sbjct: 3343 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE--ESQG 3400
Query: 1306 PSGARRNI----LQTLKRHEAAESELLATRRHVEALQQVGRELL--SRRPCGQEDIQTRL 1359
P G L K + E E L ++ + + +G+ L+ + + + ++ L
Sbjct: 3401 PVGMETETINQQLNMFKVFQKEEIEPLQGKQ--QDVNWLGQGLIQSAAKSTSTQGLEHDL 3458
Query: 1360 QGLRSKWEALNRKMTERGDELQQA--------GQQEQLLRQLQDAKEQL-EQLEGALQSS 1410
+ ++W+ LN+K+ +R +LQ+A E LL + D +E + Q + +
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518
Query: 1411 ETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELL 1470
++ + LQ+ +S + + +A+ A A IL++ R E L
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSRWEAL 3577
Query: 1471 QGHLAIRGLQLQ----ASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRK 1526
R QL+ + + H+ N L+ + + + + P T+ + + +
Sbjct: 3578 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG-TQASKLEEQI-AQ 3635
Query: 1527 HKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHW-AELERACEARAQ 1585
HK L+ ++ H + + +S G+SL + + +V+ + W E++ +R++
Sbjct: 3636 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3695
Query: 1586 CLQQAVTFQQYF-LDVSELEGW---VEEKRPLVSSRDYGRD----EAATLRLINKHQALQ 1637
LQQA+ + F D EL W V +K +S +DY + + + LR++ + L+
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3755
Query: 1638 EELA--IYWSSMEELDQTAQTLTGPEV---PEQQRVVQERLREQLRALQELAATRDRELE 1692
++ + +E L QT TG EV ++ ++ R ++ + ++A T ++ L+
Sbjct: 3756 KQNVDQALLNGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811
Query: 1693 GTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
RLH E+L WL + E+ E A + + + + + +
Sbjct: 3812 LARRLHS---THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3868
Query: 1753 AACRLLAESLLE-----RGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
+ ++ +LLE MV + + + + + + A+ ++ +
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928
Query: 1808 HRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
L +T+ ++K SL ++ + AQL+ + E++ + + +L+++ ++
Sbjct: 3929 ADAELSWITETEKKLMSL-GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3987
Query: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR-LLARFRTAVRDYASWAAR 1926
C + +++++ V + + + + +R QLERA+ L+ +F + W
Sbjct: 3988 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 4047
Query: 1927 VRQDL-QVEESSQEPSSGPLKLSAHQWLR-------AELEAREKLWQQATQLG------- 1971
+ + Q+ + E + + H+ LR ++ K Q +L
Sbjct: 4048 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 4107
Query: 1972 QQALLAAGTPTKEVQEELR--------------ALQDQRDQVYQTWARKQERLQAEQQEQ 2017
Q+ +AA T +++E+++ D+ DQ+ ++ R ERL +Q
Sbjct: 4108 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL---RQPP 4164
Query: 2018 LFLRECGRL-EEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRER 2076
E ++ E+I + VS+ L E ++Q + E + DK +A +
Sbjct: 4165 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQ 4221
Query: 2077 LKTLRRPRVRDRLPILLQRR----MRVKELAESRGHALHASLLMASFTQAATQAEDWIQA 2132
K + + + + L++ R + V ELAE + H SL++ +D+I
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAE-KFWCDHMSLIV-----TIKDTQDFI-- 4273
Query: 2133 WAQQLKEP-VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQ-SHPRAGE 2190
+ L++P + P ++ + + + E+ +E + V G L+A P
Sbjct: 4274 --RDLEDPGIDPSVVKQQQEAA---ETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4328
Query: 2191 VSQRLQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKM-NVGDL 2248
V + + L W+ L +A R +LE+ + +++ + W+ K+ ++ +
Sbjct: 4329 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4388
Query: 2249 GQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLN 2308
G DLE Q L++F+ + + + ++L L+ K + + + +L
Sbjct: 4389 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELK 4447
Query: 2309 NRWASFHGNLLRYQQQLEGA-LEIHVLSRELDNVTKRIQEKEALI-QALDCGKDLESVQR 2366
W S ++ Q +LEGA L + LD + + E L+ + G D ++++
Sbjct: 4448 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507
Query: 2367 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQ 2425
L KH L+ +V Q+ VE++ + L + S E A L+++ + + + W + + +
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567
Query: 2426 KRREALD-ALHQAQKLQAMLQEL---LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECK 2481
+R++ LD AL QA+ +++L L + R + + P P A+ L H E
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTE--RHLLASKPLGGLPETAKEQLNVHMEVC 4625
Query: 2482 AELDSWTDSISLARSTGQQLLTAGHPFSSD--IRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
A ++ ++ GQQ+L A P S++ I Q + L+++ S+E E + +L++
Sbjct: 4626 AAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4684
Query: 2540 ALELQL-FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAG 2595
AL L + F +S++ WL E +L P ++ +L+ +HK+ + EV +
Sbjct: 4685 ALNLAMEFHNSLQDFINWLTQAEQTLNVAS--RPSLILDTVLFQIDEHKV--FANEVNSH 4740
Query: 2596 KISALEATARGLHQGGHPEAQSAL---GRCQAMLLRKEALFRQAGTRRHRLEELR-QLQA 2651
+ +E G H + Q + ++ R E + ++ R L++ R + +
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800
Query: 2652 FLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
F + ++ WL EK+L + E D + QL + + FQ L A R G
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860
Query: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELEN 2766
+ L + A + + + L EL W + S ++ KL++A + + +++ L +
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4920
Query: 2767 WLEPIEVELR--APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
WL +E +L P G + V L+ + + + K+ +AL A+ +
Sbjct: 4921 WLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4979
Query: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLP-LAAA 2883
+ V+ Q + L R++++ ++T LEA R A+E + V L LA A
Sbjct: 4980 DSSWVKVQMQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEA 5033
Query: 2884 QD-------YGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH-----FA 2931
+ A+R L +QH+ ++ A G ++ H
Sbjct: 5034 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093
Query: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
H + + E+ +A + R L Q+ L LL W D E
Sbjct: 5094 KHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5153
Query: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQT 3026
+ E +AL+ + ++ P ++++ +T
Sbjct: 5154 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKT 5188
Score = 150 bits (380), Expect = 2e-35
Identities = 341/1796 (18%), Positives = 693/1796 (38%), Gaps = 169/1796 (9%)
Query: 253 QTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAA 312
+T+ +++ + QLQE L +++ + LL W+ + + +L A P S A
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPS--------AE 3516
Query: 313 FTIFRTQEKPPRLQQRGAAEALLFRLQT--ALQAQNRRPFLPHEGLGLAELSQCWAGLEW 370
F + + Q + +L QR L R T ++ + + E ++ + + L+
Sbjct: 3517 FKVVKAQIQEQKLLQR----LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDS 3572
Query: 371 AEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAA 430
A + R QL+ + +A++F +L E+ L + +E
Sbjct: 3573 RWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3632
Query: 431 VQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQ 490
+ + LE I+ I L+ D+ + + + + W +Q
Sbjct: 3633 IAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS 3692
Query: 491 RKQVADM---------QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
R ++ + + L+ + +L +L ST + + +LQ
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3752
Query: 542 LLEAQVSAHGAHVSHLAQQTAE-LDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALL 600
LL Q +V E L + G V ++Q K + + + L L
Sbjct: 3753 LLRKQ------NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 601 EQTLQRAEFLRNCEEEE-AWLKECGQRV----GNAALGRDLSQIAGALQKHKALEAEVHR 655
EQ LQ A L + EE WL + + G + SQ A + K L+ E
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ---AQMRPKELKKEAKN 3863
Query: 656 HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG-GWQLLQTRVVGRGARLQTALLVLQ 714
++A+ L L P + E+ A ++L+ + + + A+L Q
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3923
Query: 715 YFADAAEA-ASWLRE---RRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
F AA+A SW+ E + SL QDQ +A+ +V + F E+ R +
Sbjct: 3924 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL---------QVQKTFTMEILRHK 3974
Query: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
+ + L G + +C + K L
Sbjct: 3975 D-------------IIDDLVKSGHKIM-------TACSEEEKQSMKKKL----------- 4003
Query: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWL-EKQTVLLQRVQ 888
D + ++Y+++ + R +LE A +L F + EL WL E Q+++ Q
Sbjct: 4004 ------DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 4057
Query: 889 P--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQR 946
P + +TL Q ++ +A K +++ + QL + PG IQ +
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 4117
Query: 947 WGQLEALKREKAVQLAHSV-EVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQL 1005
+ Q++ +++AV L ++ + F + L ++ +L S+E Q+
Sbjct: 4118 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4177
Query: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGY------------AESQPLQGQVETLQGLLKQVQ 1053
++ K + ++ + LQ + +++ G ++ +Q +++ + + + +
Sbjct: 4178 SENKNVSVD--MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4235
Query: 1054 EQVAQRARRQAET-QARQSFLQESQQLLLWAESVQAQLRS-KEVSVDVASAQRLLREHQD 1111
V +R + + + + F + L++ + Q +R ++ +D + ++ +
Sbjct: 4236 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295
Query: 1112 LLEEIHLWQERLQ-QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQ 1170
+ EEI QE L ++ S+ +AA PD V ++ L L W+ R L+
Sbjct: 4296 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4355
Query: 1171 EGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVREALSLLQQHREFGRLL 1222
E +Q + DG A W+ + +G D+ +++ ++F
Sbjct: 4356 EA--MQAAVQYQDGLQAVF----DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4409
Query: 1223 STLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLL-ASL 1279
E L E L++ ++ HTV++ L ++ W L+ R R+ +L A L
Sbjct: 4410 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4469
Query: 1280 QLQEWKQDVAELMQWM-EEKGLMAAHEPSGARRNILQ-TLKRHEAAESELLATRRHVEAL 1337
L +++ + EL+ W+ +GL++ +P G ++ L +H ++++LA + VEA+
Sbjct: 4470 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529
Query: 1338 QQVGRELLSRRPCGQE--DIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLR-QLQ 1394
+ G +L+ G+E ++Q +L+ L +W+ + K +R +L A +Q + +++
Sbjct: 4530 NKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4588
Query: 1395 DAKEQLEQLEGALQSSETGQDLRSSQRLQKR-HQQL----ESESRTLAAKMAALASMAH- 1448
D ++ L E L +S+ L + + Q H ++ E++ T + M M
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4648
Query: 1449 -GMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNME-LSWVAEHMP 1506
+A I ++ + E ++ L R +L+ ++ L H S + ++W+ +
Sbjct: 4649 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQ 4708
Query: 1507 HGSPTSYTE-CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQ 1565
+ S L+ +HK EV +H+ Q+ + +G L Q +++
Sbjct: 4709 TLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN 4768
Query: 1566 CQ-ELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SELEGWVEE-KRPLVSSRDYGRD 1622
++ W ++ + R + L A + F + S+L W+EE ++ L S + D
Sbjct: 4769 LLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIAND 4828
Query: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV----VQERLREQLR 1678
+ +H+ Q+ L S + ++T ++L + + LR++
Sbjct: 4829 PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD 4888
Query: 1679 ALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
+ + R +LE L +F + L WL + + + D + ++L
Sbjct: 4889 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDN 4948
Query: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR--- 1794
FQ ++ + V A + A L+E V+ + Q+L T W + L+ ++
Sbjct: 4949 HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 5008
Query: 1795 -GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGT 1853
ALR E V LLE L + E+ + D L + H+ ++L
Sbjct: 5009 LEAALRQAEEFHSVVHALLEWLAEA-EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 5067
Query: 1854 ERQLQELLETAGRVQKLCPGPQAHAVQ------QRQQAVTQAWAVLQRRMEQRRAQLERA 1907
+L + V +C ++ + + AWA + Q+R A
Sbjct: 5068 RAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA----KQHQQRLASALA 5123
Query: 1908 RLLAR--FRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
L+A+ A+ + WA D E QE ++ HQ E+ ++
Sbjct: 5124 GLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5179
Score = 139 bits (349), Expect = 7e-32
Identities = 526/2741 (19%), Positives = 1032/2741 (37%), Gaps = 421/2741 (15%)
Query: 824 DPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVL 883
D + + + Q + + + L RL F EL+ + KQ L
Sbjct: 1722 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1781
Query: 884 LQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEEL 943
+ +Q A L + ENFL G+ L E + EQ N +I+ +Q L
Sbjct: 1782 QKDMQGSAQALAEVVKNTENFLKEN--GEKLSQEDKALIEQKL-----NEAKIKCEQLNL 1834
Query: 944 SQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL 1003
+ E L + + E + +++ ++ ++ ++L L + S
Sbjct: 1835 KAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---- 1889
Query: 1004 QLAQKKTLVLERRVHFLQ-----SVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ 1058
+ K ++ + HF + ++ + E G + GQV T Q L Q ++V
Sbjct: 1890 --TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947
Query: 1059 R-----ARRQA---ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
+ ++ QA TQ+ Q L++ Q L E + Q KE+ V +A L E +
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA---LAESE 2004
Query: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ--QW 1168
++ H QE L++ DA D E + L+ Q QEL+ L
Sbjct: 2005 KKMKLTHSLQEELEKFDA-----------DYTEFEHWLQ---QSEQELENLEAGADDING 2050
Query: 1169 LQEGLELQKFGREVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
L L+ QK F+ +H+ L ++ G V EA + R+ G+ + T
Sbjct: 2051 LMTKLKRQK------SFSEDVISHKGDLRYITISGNRVLEAAKSCSK-RDGGK-VDTSAT 2102
Query: 1228 RAEALRA--HGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWK 1285
E R H +S + + + L+ + ++ + S LLA LQ E
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS----CGLLAGLQACE-- 2156
Query: 1286 QDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELL 1345
A + + E A +P +N+ + L+ +A + ++ + + VE L++ LL
Sbjct: 2157 ---ATASKHLSEP---IAVDP----KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL 2206
Query: 1346 SRRPC---GQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQL--QDAKEQL 1400
R + DIQ L + ++E L++ + ER ++LQ L R L QD +++
Sbjct: 2207 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT-----LTRSLSVQDGLDEM 2261
Query: 1401 EQLEGALQSS--ETGQDLRSSQRLQ---KRHQQLESESRTLAAKMAAL------------ 1443
G ++SS E GQ +S LQ ++ LE + + + A+
Sbjct: 2262 LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 2321
Query: 1444 ASMAHGMAA-----SPAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMEL 1498
S A + A S E + KH L ++ L S +L F L
Sbjct: 2322 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2381
Query: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
+ V +P T ++ + + S +HK+ ++ + S + +++ G P
Sbjct: 2382 TEV--DVPGKDVTELSQYMQESTSEFLEHKK----------HLEVLHSLLKEISSHGLPS 2429
Query: 1559 AQHIV-EQCQELEGHWAELERAC----EARAQCLQQAVTFQQYFLDVSELEGWVEEK--- 1610
+ +V E+ L + E+E EA C +Q FQ + V L+ W++E
Sbjct: 2430 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQ---VLVKSLKSWIKETTKK 2486
Query: 1611 ----RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGP------ 1660
+P + D G+ T +L K E+ +S L +T P
Sbjct: 2487 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2546
Query: 1661 ---------------------------EVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
+ + + + L++ A + +L
Sbjct: 2547 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS- 2605
Query: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGES--LGEDPEHALHLCTKFAKFQHQVEMGSQR 1751
+L + E+ + WL + A + D E + F+ +++ +
Sbjct: 2606 --KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2663
Query: 1752 VAACRLLAESLLERGHSA--GPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
V + LLE P +Q ++ + W EL +LT R L ++ L +
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2723
Query: 1810 DLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
+ L Q +E S+ ++ D L Q + Q L +E T + E L AG+
Sbjct: 2724 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF-ATRKPQYEQLTAAGQ 2782
Query: 1867 VQKLCPGPQAH---AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA-RFRTAVRDYAS 1922
PG V+++ AVTQ W L ++ R +++A + + ++++ +R +
Sbjct: 2783 GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2842
Query: 1923 WAARVRQDLQVEES-SQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQ--QALLAAG 1979
+ + L + S P + +L Q ++ E++ +K + A L + AL+
Sbjct: 2843 KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE 2902
Query: 1980 TPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEE--ILAAQEVSL 2037
E+ +L + V Q + LQ+ ++ R + + +E
Sbjct: 2903 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2962
Query: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK-EAALRERLKTLRRPRVRDRLPILLQR- 2095
K+ + + ++ +E LI+ H+ F K LTAQ E + E L + + ++ + LQ
Sbjct: 2963 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 3022
Query: 2096 ---------RMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL 2146
+VKE +L +L + + WI L+E D
Sbjct: 3023 TIKTNWDTFNKQVKERENKLKESLEKAL---KYKEQVETLWPWIDKCQNNLEEIKFCLDP 3079
Query: 2147 RDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLR 2206
+ + K ++ + E+ H ++ + +LL+ V+ + L + + +
Sbjct: 3080 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3139
Query: 2207 QAMALRGQELED-RRNFLEFLQRVDLAEAWIQEKEVKMNVGD-LG--------------- 2249
+ + + LE+ + F EF + ++ +Q + ++++ D LG
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199
Query: 2250 ----QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRS 2305
Q L+H + L +RL + A D+ G SD+ LQ V+ I Q S
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKG------TSDVLLQ--------VETIAQEHS 3245
Query: 2306 QLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQ 2365
L+ QQ E + + + + I +E Q + +L+S+
Sbjct: 3246 TLS-------------QQVDEKCSFLETKLQGIGHFQNTI--REMFSQFAEFDDELDSMA 3290
Query: 2366 RLLRKHEELEREVHPIQAQVESLER------EVGRLC-------QRSPEAAHGLRHRQQE 2412
+ R E L+++ I+A ++ LE + C + SP+ G++ +
Sbjct: 3291 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEA 3349
Query: 2413 VAESWWQLRSRAQKRREALD-ALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA- 2470
+++ +L RAQ R E ++ + + ++ + L+E + Q+ ++ E
Sbjct: 3350 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3409
Query: 2471 ---RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
M + Q K E++ GQ L+ + +S GLE +L +
Sbjct: 3410 NQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAKSTS-----TQGLEHDLDDVN 3462
Query: 2528 GAWQ-------EHQLQLQQA-LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
W+ + QLQ+A L F ++E + W+ E+ +A++ P A + +
Sbjct: 3463 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK--PPSAEFKVV 3520
Query: 2580 ---LWKHKMLEWDLEVQAGKISALEATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQ 2635
+ + K+L+ L+ + + ++ + P + L + + R EAL +
Sbjct: 3521 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3580
Query: 2636 AGTRRHRLEELRQL-QAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQ 2692
A TR +LE + + Q F + + + WL EK LV E + L Q+ + + +
Sbjct: 3581 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3640
Query: 2693 AE-LDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKA 2751
+ ++ + H Q + + + +Q +L+ + E+Q+ S + LQ+A
Sbjct: 3641 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3700
Query: 2752 -CEALRLRRSMEELENWLEPIEVELRAPTV-GQALPGVGELLGTQRELEAAVDKKARQAE 2809
C A EL NWL + +L +V + G+ + R L+ + + + +
Sbjct: 3701 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVD 3760
Query: 2810 ALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE 2869
QA + L Q ++ +Q++ A++AR ++D
Sbjct: 3761 ------QALLNGLELLKQTTGDEVL-----------IIQDKLEAIKAR------YKDI-- 3795
Query: 2870 EMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNL-------ESEMSSHEALTRVVLGTGY 2922
KL A+ Q+L R L H+ L E E+ S+E T+V+ G
Sbjct: 3796 ------TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE--TQVLKG--- 3844
Query: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
E A++ Q K L+ EA + LL E L EL+ W A
Sbjct: 3845 -----------EEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELV---PWRAR 3887
Query: 2983 RG-HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
G + +ED + + +++E +++A R ++ Q A
Sbjct: 3888 EGLEKMVAEDNERYRLVSDTITQKVE----EIDAAILRSQQFDQAAD------------- 3930
Query: 3042 LAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQD 3101
A+L + E +L+ + R Q QL + T+ + +D D
Sbjct: 3931 -AELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI----------LRHKDIIDD 3979
Query: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWER 3161
L VK + A +E + + K+ + K T+ + RY ++ +S + WE
Sbjct: 3980 L--VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 4037
Query: 3162 LDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRR 3221
++ TE Q ++L E ++R Q++HR+
Sbjct: 4038 YEELWPWLTET----------QSIISQLPAPALE-------------YETLRQQQEEHRQ 4074
Query: 3222 LERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQE--------RGQ 3273
L + + + ++ +L +L P + + A TL ++ +E +
Sbjct: 4075 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 4134
Query: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
++Q+ Q H + + E L ER L ++ +V ++ + +++ + ++ + +
Sbjct: 4135 AISQSTQFHDKIDQILESLERIVER--LRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4192
Query: 3334 QAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
+ L+Q G++++ S +++ + ++ +L ++ W
Sbjct: 4193 LYETLKQRGEEMIARSGGTDKDIS--AKAVQDKLDQMVFIW 4231
Score = 136 bits (342), Expect = 4e-31
Identities = 621/3295 (18%), Positives = 1193/3295 (36%), Gaps = 526/3295 (15%)
Query: 469 VARRQEEVTVRWQRLLQHL-QGQRKQVADMQAVLSLLQEVEAASHQL--EELQEPARSTA 525
VA RQ+E + Q + L Q + + + +A + VE +Q EELQ+ + +A
Sbjct: 1730 VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSA 1789
Query: 526 CGQQLAEVV-----------ELLQRHD-------LLEAQVSAHGAHVSHLAQQTAELDSS 567
Q LAEVV E L + D L EA++ ++ Q ELD
Sbjct: 1790 --QALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLK-AEQSKKELDKV 1846
Query: 568 LGTSVEVLQAKARTLAQLQQSLVALVRA-----------------RRALLEQT---LQRA 607
+ T+++ K + QL++S + + ++EQ Q
Sbjct: 1847 VTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEG 1906
Query: 608 EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKAL-EAEVHRHQAVCVDLVRR 666
+ EE+ + + +G + QK KA E + +HQAV +
Sbjct: 1907 DGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSA 1966
Query: 667 GRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQ-----YFADAAE 721
L + P+ E+ + ++ + + LQ + AD E
Sbjct: 1967 QVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTE 2026
Query: 722 AASWLRERRSSLERASCGQDQA-AAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
WL++ LE G D T L+R + + +LR + G A
Sbjct: 2027 FEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAA 2086
Query: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
SC G + D + + DH +
Sbjct: 2087 K------------------------SCSKRDG--------GKVDTSATHREVQRKLDHAT 2114
Query: 841 QDYESLRALAQLRRARLEEAMALFGFC--SSCG-------------------------EL 873
+ SL + + L++ + + +SCG L
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2174
Query: 874 QLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNS 933
Q LE+ L ++ Q +E ++ E L A ++ + + + RY S
Sbjct: 2175 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2234
Query: 934 TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQP 993
+ + E+L + L S+ V L E + L + +
Sbjct: 2235 KSVNERNEKLQ--------------ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280
Query: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ-GQVETLQGLLKQV 1052
S+ ALQ K ++LE+ + QS + + E + +LQ +K +
Sbjct: 2281 NST-----ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2335
Query: 1053 QEQVAQRARRQAETQARQSFLQESQQLLL-WAESVQAQLRSK-----EVSVDVASAQRLL 1106
+ ++ + + ET A+ L+ +L +E +Q L +K EV V L
Sbjct: 2336 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS 2395
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
+ Q+ E ++ L+ L + + ++ S +P+ ++ ++ L +++ +
Sbjct: 2396 QYMQESTSEFLEHKKHLEVLHSLLKEIS------SHGLPSDKALVLEKTNNLSKKFKEME 2449
Query: 1167 QWLQEGLE-LQKFGREVDGFTATCANHQAWLH--------------LDNLGEDVREALSL 1211
++E E + ++D F + ++W+ ++LG+ + + L
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKL 2509
Query: 1212 ----------LQQHREFG----RLLSTLGPRAEALRA--HGEKLVQSQHPAAHT----VR 1251
+Q+ G L+S + A+A+ A G ++ + A +T
Sbjct: 2510 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2569
Query: 1252 EQLQSIQAQWTRLQGRSEQRRRQL---LASL-----QLQEWKQDVAELMQWMEEKGLMAA 1303
+ L SI+ T + E L +A L +LQ+ +++ + +MQW+++ A
Sbjct: 2570 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2629
Query: 1304 ---HEPSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTR- 1358
P+ ++T ++++++ E+EL V+ L+ ELL P E + +
Sbjct: 2630 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2689
Query: 1359 -LQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQ--LEGALQSSETGQD 1415
L + SKW+ LN+ +R +L+++ L Q Q + QL+Q +E L S G
Sbjct: 2690 MLTEIDSKWQELNQLTIDRQQKLEESSNN---LTQFQTVEAQLKQWLVEKELMVSVLGPL 2746
Query: 1416 LRSSQRLQKRHQQLE---SESRTLAAKMAALASMAHGMAASPA--------ILEETQKHL 1464
L + QQ++ E T + L + G+ + P + E+
Sbjct: 2747 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2806
Query: 1465 RRLELLQGHLAIRGLQL-QASVELHQFCHL--------SNMELSWVAEHMPHGSPTSYTE 1515
++ + L G L+ R + QA V+ Q+ L S+++ + P + +
Sbjct: 2807 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2866
Query: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRV--LSSGRSLAASGHPQAQHIVEQC----QEL 1569
L AQ + ++ ++ + ++K Q + + L L A Q + I++ Q+
Sbjct: 2867 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2926
Query: 1570 EGHWAELERACEARAQCLQQAVTFQQYFLDVSELE----GWVEEKRPLVSS-----RDYG 1620
E H L+ AC + Q Q + FQ + LD + E + K ++ S +D+
Sbjct: 2927 ENHVQHLQSACASSHQFQQMSRDFQAW-LDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2985
Query: 1621 RDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRVVQER 1672
+ A + K A E L + E+ Q T +V E++ ++E
Sbjct: 2986 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 3045
Query: 1673 LREQLR-----------------ALQELAATRD-RELEGTL-RLHEFLREAEDLQGWLAS 1713
L + L+ L+E+ D E E ++ +L +E + G +
Sbjct: 3046 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 3105
Query: 1714 QKQAAKGGESLGE-DPE--------------------HALHLC-----TKFAKFQHQVEM 1747
A S+ E D E H+ C KF +FQ +V
Sbjct: 3106 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ-EVSK 3164
Query: 1748 GSQRVAACRLLAESLLERGHSAG---------PMVRQRQQDLQT-----------AWSEL 1787
S+R C A+ L+ S G M++ +Q+ LQ A +
Sbjct: 3165 ESKRQLQC---AKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3221
Query: 1788 WELTQARG--HALRDTETTLRVHRDLLEVLTQVQEKATSLP---------NNVARDL--- 1833
E + ++G L ET + H L + QV EK + L N R++
Sbjct: 3222 VEASDSKGTSDVLLQVETIAQEHSTLSQ---QVDEKCSFLETKLQGIGHFQNTIREMFSQ 3278
Query: 1834 -CGLEAQLRSHQGLERELVGTERQ----------LQELLETAGRVQKLC--------PGP 1874
+ +L S + R+ ++Q L+ L+ + K C P
Sbjct: 3279 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3338
Query: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE-RARLLARFRTAVRDYASWAARVRQDLQV 1933
+++ +A+++ L R + R Q+E + L F + +++++ + Q +
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI----LLQKAEE 3394
Query: 1934 EESSQEPSSGPLKLSAHQ------WLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
E SQ P + Q + + E+E + Q LGQ + +A T
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST----- 3449
Query: 1988 ELRALQDQRDQVYQTWARKQERL-QAEQQEQLFLRECGRLEEILAA--------QEVSLK 2038
+ L+ D V W +++ Q Q Q L CGR ++ L + +E+
Sbjct: 3450 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3509
Query: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR---ERLKTLRRP----RVRDRLPI 2091
+ + V+ I++ ++ ++L + ++ E++ T P ++ +L +
Sbjct: 3510 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3569
Query: 2092 LLQRRMRVKELAESRGHALHA-SLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKL 2150
L R + AE+R L S++ F + +W+ ++L P G KL
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3629
Query: 2151 -KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW------- 2202
+ + +H+A E ++ H + + G++L S ++ Q + W
Sbjct: 3630 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3689
Query: 2203 -----EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
E L+QA+ ED + +L V +K K++V D + Q
Sbjct: 3690 SHSRSELLQQALCNAKIFGEDEVELMNWLNEV-------HDKLSKLSVQDYSTEGLWKQQ 3742
Query: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
R+ + V A + + LK +EV II + + R+
Sbjct: 3743 SELRVLQEDILLRKQNVDQALLNGLE----LLKQTTGDEVLIIQDKLEAIKARYKDITKL 3798
Query: 2318 LLRYQQQLEGALE----IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373
+ LE AL+ +H EL ++ E E L K E+ Q +R +E
Sbjct: 3799 STDVAKTLEQALQLARRLHSTHEELCTWLDKV-EVELLSYETQVLKGEEASQAQMRP-KE 3856
Query: 2374 LEREVHPIQAQVESLEREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALD 2432
L++E +A ++SL L + P A GL E E + + ++ E +D
Sbjct: 3857 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916
Query: 2433 A--LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
A L Q QA EL + + M + L+ + E+ D
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976
Query: 2491 ISLARSTGQQLLTA-GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL-QLFLS 2548
I +G +++TA +++ L + + ++ E LQL++A L F
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036
Query: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLW---KHKMLEWDLEVQAGKISALEATAR 2605
+ E++ WL + ++ L P E L +H+ L + I + T
Sbjct: 4037 TYEELWPWLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 4094
Query: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL--------RQLQAFLQDSQ 2657
L + E S + A + R L+E ++ L+ +
Sbjct: 4095 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4154
Query: 2658 EVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL--QG 2715
+ LR+ ++ E + Q+ + +N +++ + L++ G+ ++ G
Sbjct: 4155 RIVERLRQPPSISAE-----VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4209
Query: 2716 GHP---ASEAIQERLEELGALWGELQDNSQKKVAKLQKA--------CEALRLRRSMEEL 2764
G +++A+Q++L+++ +W + +++ AKL C+ + L ++++
Sbjct: 4210 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4269
Query: 2765 ENWLEPIEVELRAPTVGQALPGVGELL-----GTQRELEAAVDKKARQAEALLGQAQAFV 2819
++++ +E P+V + E + G Q EL+ ++ + A G+ +
Sbjct: 4270 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN-LGSELIAACGEPDKPI 4328
Query: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWVQ-EK 2877
V++ L + SL + ++R L EA +++ WV
Sbjct: 4329 ---------VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAG 4379
Query: 2878 LPLAAAQDYGQSLSAVRHLQEQ---------HQNLESEMSSHEA--LTRVVLGTGYKLVQ 2926
LA+ G L V+ E+ Q +E E +H+A L + V K
Sbjct: 4380 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK--- 4436
Query: 2927 AGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEA-QQFLTELLEAGSWLAE-RG 2984
H V + +L+ L R+ L+ A A QF L E +WL G
Sbjct: 4437 ------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4490
Query: 2985 HVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTA-ALLESRKNPESPKVLA 3043
+ + + +G +A + L + + D+ A +E + + L+ES E+ +
Sbjct: 4491 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4550
Query: 3044 QLQAVREAHAELLRRAEARG-------------HGLQEQLQLHQLERETLLLDAWLTTKA 3090
+L+ + + +L + E R HG E LQ + E LL +
Sbjct: 4551 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4610
Query: 3091 ATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQA 3150
+ +E E K + ++ +Q GQ + K A T +I
Sbjct: 4611 PETAKEQLNVHMEVCAAFEAKEETYKSLMQK-GQQMLARCPKSAET----------NIDQ 4659
Query: 3151 QRSRIEAAWERLDQAIKAR----TENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGG 3206
+ ++ WE ++ + R E L A E H+ Q + Q + L
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF--INWLTQAEQTLNVASRPS 4717
Query: 3207 HSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK-----VQEAW 3261
L +V +H+ E+ + +++ L L L K VQ W
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777
Query: 3262 ATLQAKAQERGQWLAQA-AQGHAFLGRCQELLAWAQERQELASSE-ELAEDVAGAEQLLG 3319
+ + ERG+ L A + F +L+ W +E ++ SE E+A D + L
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837
Query: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAW 3374
QH+E + + + G+ L + + + +L+ L EL + W
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-----KLDDMLSELRDKW 4887
Score = 132 bits (331), Expect = 8e-30
Identities = 377/1983 (19%), Positives = 758/1983 (38%), Gaps = 238/1983 (12%)
Query: 306 MRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCW 365
+ Q L F +F+ +E P ++ L L + L H+ L +++ W
Sbjct: 3409 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHD---LDDVNARW 3465
Query: 366 AGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLA 425
L A R+ LQ+ LL RFQ S++ D E+++ + P A
Sbjct: 3466 KTLNKKVAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518
Query: 426 TVEAAVQRLGMLE---------AGILPQEG-RFQALAEIADILRQEQYHSWADVARRQEE 475
V+A +Q +L+ ++ +EG + AE AD ++ + ++
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK---------ILKQLSL 3569
Query: 476 VTVRWQRLLQHLQGQRKQVADMQAVLSLLQE-VEAASHQLEELQEPARSTAC---GQQLA 531
+ RW+ LL + + +Q+ + V E +E + L +++ R C G Q +
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK--RLVNCEPIGTQAS 3627
Query: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA---KARTLAQLQQS 588
++ E + +H LE + H H+ S+G S++VL + K ++L S
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAV--------SIGQSLKVLSSREDKDMVQSKLDFS 3679
Query: 589 LVALVR------ARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNAALGRDLSQIAG 641
V + +R LL+Q L A+ E E WL E ++ ++ ++
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3739
Query: 642 ALQKH-KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
Q + L+ ++ + + G +L + G+ +Q + ++
Sbjct: 3740 KQQSELRVLQEDILLRKQNVDQALLNGLEL------LKQTTGDEVLIIQDKLEAIK---- 3789
Query: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
AR + + A E A L R S C LL ++ +
Sbjct: 3790 ---ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEE 3846
Query: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
A A++R E + A + +A L ++N S E + W+
Sbjct: 3847 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV-----------------PWRAREG 3889
Query: 821 AEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL--- 877
E D D ++Q E + A A LR + ++A + EL W+
Sbjct: 3890 LEKMVAEDNERYRLVSDTITQKVEEIDA-AILRSQQFDQA--------ADAELS-WITET 3939
Query: 878 EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-I 936
EK+ + L ++ + D + F + K + ++ S ++ Q +
Sbjct: 3940 EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3999
Query: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFL----QECGPTQVQLRDVLLQLEALQ 992
+++ +++ + + + + E+ +QL + + + +E P + + ++ QL A
Sbjct: 4000 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA-- 4057
Query: 993 PGSSEDTCHALQLA--QKKTLVLERRVHF--LQSVVVKVEEPGYAESQPLQGQVETLQGL 1048
P +T Q Q + L+ E + H + ++ E E +Q + L
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 4117
Query: 1049 LKQVQEQVAQRARRQAETQARQS-FLQESQQLLLWAESVQAQLRSK-EVSVDVASAQRLL 1106
Q++E V +RA E ++ + F + Q+L E + +LR +S +V + +
Sbjct: 4118 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4177
Query: 1107 REHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWE--- 1163
E++++ ++ Q + L + + M A +++ + + + + ++ +WE
Sbjct: 4178 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFIWENIH 4235
Query: 1164 ----QRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNLG-------------ED 1204
+R+ L + +EL +KF + T + Q ++ L++ G E
Sbjct: 4236 TLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295
Query: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1264
+RE + LQ+ + ++ LG +E + A GE P V++ + + + W L
Sbjct: 4296 IREEIDGLQEELD---IVINLG--SELIAACGE-------PDKPIVKKSIDELNSAWDSL 4343
Query: 1265 QGRSEQRRRQLLASLQLQEWKQD-VAELMQWME-EKGLMAAHEPSGAR-RNILQTLKRHE 1321
+ R +L ++Q QD + + W++ G +A+ P G + Q ++ +
Sbjct: 4344 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4403
Query: 1322 AAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGLRSKWEALNRKMTERGD 1378
+SE + +E L ELL ++ + D +Q L L+ W++L ++ R
Sbjct: 4404 QFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH 4462
Query: 1379 ELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSE-TGQDLRSSQRLQKRHQQLESES 1433
+L+ A GQ + L +L L EG L + G D ++ + +H L+++
Sbjct: 4463 KLEGALLALGQFQHALDELL---AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 1434 RTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQASVE 1486
+ + A+ + + S A EE +LE+L R QL ++
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAG-EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578
Query: 1487 LHQFCHLSNMELS-WVAEHMPH--------GSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
+ H +L W+ + H G P + E LN H E+ +A
Sbjct: 4579 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN-------VHMEVCAAFEAK 4631
Query: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQY 1596
+ + ++ G+ + A A+ ++Q L+ W +E R L++A+
Sbjct: 4632 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691
Query: 1597 FLD-VSELEGWVEEKRPL--VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQT 1653
F + + + W+ + V+SR + + I++H+ E+ + + ELD+T
Sbjct: 4692 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKT 4750
Query: 1654 AQTLTGPEVPEQQRVV---------QERLREQLRALQELAATRDRELEGTLRLHEFLREA 1704
L ++Q VV Q R + ++ L E + D + + HE +
Sbjct: 4751 GTHLK--YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK- 4807
Query: 1705 EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE 1764
L WL +++ + DP+ + +FQ + SL E
Sbjct: 4808 --LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4865
Query: 1765 RGHSAGPMVR--QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ--- 1819
+ A ++ +L+ W + + R + L + D L+ L
Sbjct: 4866 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4925
Query: 1820 EKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA- 1878
E + V D+ + + +H+ ++EL +Q L +A ++L G + +
Sbjct: 4926 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA---RELIEGSRDDSS 4982
Query: 1879 -VQQRQQAVTQAWAVLQRRMEQRRAQLERA-RLLARFRTAVRDYASWAARVRQDLQVEES 1936
V+ + Q ++ W + ++ +LE A R F + V W A Q L+
Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGV 5042
Query: 1937 SQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQ 1995
+ L H+ +LE + +AT +G L + + +
Sbjct: 5043 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKT------SALGSSVEEV 2049
R + WA++ ++ A L ++ LE +LA + + T + +EEV
Sbjct: 5103 RFEEVLAWAKQHQQRLASALAGLIAKQ-ELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5161
Query: 2050 EQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHA 2109
+ LI +H+ F++ +T +K+ + + KT +R R D P LQ + V + +
Sbjct: 5162 KALIAEHQTFMEEMT---RKQPDVDKVTKTYKR-RAAD--PSSLQSHIPVLDKGRAGRKR 5215
Query: 2110 LHASLLMASFTQAATQAED---------WIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
AS L S +Q + ++ W Q W L+ D D+L+ L + F+
Sbjct: 5216 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 5275
Query: 2161 AEV 2163
++
Sbjct: 5276 FDI 5278
Score = 110 bits (275), Expect = 3e-23
Identities = 371/2042 (18%), Positives = 761/2042 (37%), Gaps = 369/2042 (18%)
Query: 1583 RAQCLQQAVTFQQYFLD-VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
++ L Q +T ++ + V +L WV+E + + ++G D + + H+ + +
Sbjct: 768 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 827
Query: 1642 IYWSSMEELDQTAQTLTGP-EVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEF 1700
+ SS++E + +T P ++ +++ RL Q L + ++R L+ LH F
Sbjct: 828 EFESSLKEAKISEIQMTAPLKLTYAEKL--HRLESQYAKLLNTSRNQERHLD---TLHNF 882
Query: 1701 LREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAE 1760
+ A + WL ++K+ + E + A+ +++ + + + + +AE
Sbjct: 883 VSRATNELIWL-NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 941
Query: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
LL H A + + +QT WS + +L Q +++ D E ++
Sbjct: 942 QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 1001
Query: 1821 KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQ 1880
++ + C + + + L +E + + +ELL+ + L
Sbjct: 1002 LKDAIQRKYS---CDRSSSIHKLEDLVQE---SMEEKEELLQYKSTIANL---------- 1045
Query: 1881 QRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEP 1940
+ +A ++Q + L+ + + A+ DY Q+E + +
Sbjct: 1046 -----MGKAKTIIQLKPRNSDCPLKTSIPI----KAICDYR----------QIEITIYKD 1086
Query: 1941 SSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL-----AAGTPTKEVQEELRALQDQ 1995
L ++H RA+ W+ + G +A++ P KE + ++ Q
Sbjct: 1087 DECVLANNSH---RAK-------WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 1136
Query: 1996 RDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRK 2055
V W +++ + E ++ I A+ S+KT G + + L +
Sbjct: 1137 YQNVLTLWHESHINMKSVVSWHYLINE---IDRIRASNVASIKTMLPGEHQQVLSNLQSR 1193
Query: 2056 HEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLL 2115
E FL +D +E+ + + + + Q ++ E E +L
Sbjct: 1194 FEDFL-----EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY--NLY 1246
Query: 2116 MASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAK 2175
++ + E+ +Q++ P+ DL + + + + + + E++ ++ + ++
Sbjct: 1247 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 1306
Query: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
K E +Q+ + + R + L +++ Q ++ ++ + L+ AEA
Sbjct: 1307 KCEEFFSQAAASSSVPTLRSE-LNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1365
Query: 2236 IQEKEVKM-----------NVGDLGQDLEHCLQLRRRLREFRG--NSAGDTVGDACIRSI 2282
++ E K+ N+ +L L+ Q R + E R ++ D + A ++I
Sbjct: 1366 VKLYETKLCEEEAVIADKNNIENLISTLK---QWRSEVDEKRQVFHALEDELQKA--KAI 1420
Query: 2283 SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVT 2342
SD + + ++ QL RW + H Q++ L
Sbjct: 1421 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVH-------VQIDNRL------------- 1460
Query: 2343 KRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEA 2402
+DLE + + L+ + + HP+ ++ +E ++ + PE
Sbjct: 1461 ----------------RDLEGIGKSLKYYRD---TYHPLDDWIQQVETTQRKIQENQPEN 1501
Query: 2403 AHGL--RHRQQEVAESWWQLR----SRAQKRREALDALHQAQKLQAMLQELLVSAQRLRA 2456
+ L + QQ++ S +++ QK E A + +LQ M +V +Q+
Sbjct: 1502 SKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ--- 1558
Query: 2457 QMDTSPAPRSPVEARRMLEEHQECKAE-LDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515
+SPV+ RRM E +D T +L Q + AG
Sbjct: 1559 --------KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG--------DS 1602
Query: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEK-------------MERWLCSKED 2562
L LE+E SLE +EH +++A ELQ ++S++ K ++ + S+E
Sbjct: 1603 LKRLEEEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEI 1659
Query: 2563 SLASEGLWDPLAPMEPLLWKH--KMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALG 2620
S E L + L ++ L KH KM + + ++ L+ + L + Q +
Sbjct: 1660 STKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT 1719
Query: 2621 RCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLL---D 2677
+ K RQ + E+L+ + L + E L+ +E +
Sbjct: 1720 SGDVKVEEKIVAERQ----QEYKEKLQGICDLLTQT--------ENRLIGHQEAFMIGDG 1767
Query: 2678 TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLL-QGGHPASE----AIQERLEELGA 2732
T L KQ+ Q ++ S E+ + + L + G S+ I+++L E
Sbjct: 1768 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1827
Query: 2733 LWGELQ---DNSQKKVAKL---------QKACEALRLRRSMEELEN---WLEPIEVEL-R 2776
+L + S+K++ K+ +K +L S ++EN WL ++ + R
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1887
Query: 2777 APT---------------------VGQALPGVGELL---------GTQRELEAAVDKKAR 2806
A T +G+ G LL TQ L K
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947
Query: 2807 QAEALLGQAQAFV-----------REGHCLAQDVEEQARRLLQRFK-----SLREPLQER 2850
Q E ++ Q QA + ++G L+ + +E+ ++ ++ K +L E ++
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007
Query: 2851 RTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
+ + L KF D E W+Q+ + L + ++ + ++ ++ ++ S
Sbjct: 2008 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 2067
Query: 2910 HEALTRVVLGTGYKLVQAGHFAAHEVAARV----------QQLEKAMAHLRAEAARRRLL 2959
H+ R + +G ++++A + +V ++L+ A R+ ++ +L
Sbjct: 2068 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 2127
Query: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEA----TQALLRRLEATKR---D 3012
++ +A L ++ H +E + L R+LE TK
Sbjct: 2128 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQ 2187
Query: 3013 LEAFSPRIERLQQTA-ALLESRKN--PESPKVLAQLQAVREAHAELLRRAEARGHGLQEQ 3069
+ + +E+L++TA LL++R + P + L + + +L + R LQ
Sbjct: 2188 ISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQIT 2247
Query: 3070 LQLHQLERETL--LLDAWLTTKAATAESQDYG-------QDLEGVKVLEEKFDAFRKEVQ 3120
L ++ L +LD W+ ++ + Q QD+ ++ E+ A R
Sbjct: 2248 LTRSLSVQDGLDEMLD-WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR---- 2302
Query: 3121 SLGQAKVYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE- 3178
Q+ + A+ K+ +E P +QA+ + A R +A E LA E
Sbjct: 2303 ---QSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA---RFSEASHKHKETLAKMEEL 2356
Query: 3179 ---VHSFQQAAAELQGRMQEKT-ALMKGEDGGHSLSSVRTLQQ-------QHRRLERELE 3227
V F+ + +LQ ++ KT AL + + G ++ + Q +H++ L
Sbjct: 2357 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2416
Query: 3228 AMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQG------ 3281
++ KE++ P A V E L K +E + + +
Sbjct: 2417 SLLKEIS------------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2464
Query: 3282 --HAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLR 3339
AF + L +W +E + + GAE L E+ + + L+ +++
Sbjct: 2465 QLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2521
Query: 3340 QEGQQLVDNSHFMSAEVTE-----------CLQELEGRLQELEEAWALRWQRCAESWGLQ 3388
+ + + +SA T + EG EE WA + GL
Sbjct: 2522 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK--------GLT 2573
Query: 3389 KLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLL-----HRHQDLEKLLAAQEEKFAQ 3443
+++ + D H D+ LLL + L KL AQEE A
Sbjct: 2574 SIKKDM----------------TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617
Query: 3444 MQ 3445
MQ
Sbjct: 2618 MQ 2619
Score = 108 bits (270), Expect = 1e-22
Identities = 472/2617 (18%), Positives = 981/2617 (37%), Gaps = 342/2617 (13%)
Query: 1098 DVASAQRLLR-EHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQ 1156
+VAS + +L EHQ +L + Q R + SQ D ++ + V Q Q
Sbjct: 1171 NVASIKTMLPGEHQQVLSNL---QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 1227
Query: 1157 ELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQ--------AWLHLDNLGEDVREA 1208
EL E+ +Q E + EV N + L D+L E V
Sbjct: 1228 ELLKSAEREEQ---EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1284
Query: 1209 LSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRS 1268
+ +E RL LG + S + T+R +L + ++ S
Sbjct: 1285 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMS 1342
Query: 1269 EQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELL 1328
+L ++ L AE + + E L + NI + + SE+
Sbjct: 1343 STYIDKL-KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 1401
Query: 1329 ATRRHVEALQQVGRELLSRRPCGQEDIQT-------------RLQGLRSKWEALNRKMTE 1375
R+ AL+ EL + E +T + L +W+ ++ ++
Sbjct: 1402 EKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1458
Query: 1376 RGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLES 1431
R +L+ G+ + R L D +Q+E + +Q ++ + +L ++ + L S
Sbjct: 1459 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ-KMLVS 1517
Query: 1432 ESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVEL--HQ 1489
E +KM A +A+ E R + Q ++ ++Q+S +L +
Sbjct: 1518 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1577
Query: 1490 FCHLSNMELSWVAEHMPHGSPTSYTECLNGA-QSLHRKHKELQVEVKAH-------QGQV 1541
F L + V T Y + + + L + K L+ E K H Q V
Sbjct: 1578 FMDLRTRYTALVT------LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1631
Query: 1542 QRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVS 1601
+ + + +G P +E+ +L A + T Q +
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ----------TIQLF----- 1676
Query: 1602 ELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPE 1661
L D DE L + + LQE + +S E L Q ++ T +
Sbjct: 1677 -----------LAKHGDKMTDEERN-ELEKQVKTLQESYNLLFS--ESLKQLQESQTSGD 1722
Query: 1662 VPEQQRVVQERLREQLRALQE----LAATRDREL---------EGTLRLHEFLREAEDLQ 1708
V ++++V ER +E LQ L T +R + +GT+ L ++ + E+LQ
Sbjct: 1723 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782
Query: 1709 GWLASQKQAA------------KGGESLGEDPEHALHLCTKFAKFQHQ------------ 1744
+ QA + GE L ++ + + AK + +
Sbjct: 1783 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE 1842
Query: 1745 --------VEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
++ +++VAA + L ES + + + +D + A ++ ++ + G
Sbjct: 1843 LDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD-WLSNVDKDSERAGTKHKQVIEQNGT 1901
Query: 1797 ALRDTETTL------RVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLEREL 1850
++ + V+ +LLE T V + + N+ + ++AQ + +
Sbjct: 1902 HFQEGDGKSAIGEEDEVNGNLLE--TDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1959
Query: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
+ + Q LLE G Q L P + + ++ L ++ + L
Sbjct: 1960 IIATQSAQVLLEKQG--QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 2017
Query: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL-KLSAHQWLRAELEAREKLWQQATQ 1969
+F ++ W + Q+L+ E+ + +G + KL + ++ + + + T
Sbjct: 2018 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 2077
Query: 1970 LGQQALLAAGTPTK-------------EVQEELRALQDQRDQVYQTWARKQERLQ--AEQ 2014
G + L AA + +K EVQ +L D+ +Y L+ ++
Sbjct: 2078 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 2137
Query: 2015 QEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALR 2074
+ CG L + A + + K + +V+ + L R+ E K L Q +
Sbjct: 2138 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDP-KNLQRQLEE-TKALQGQISSQQVAV 2195
Query: 2075 ERLKTLRRPRVRDRLPIL-----LQRRM-----RVKELAES---RGHALHASLLMA-SFT 2120
E+LK + R +L +Q+ + R ++L++S R L +L + S
Sbjct: 2196 EKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2255
Query: 2121 QAATQAEDWIQAWAQQLKE----PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKK 2176
+ DW+ LKE P+ L+D + K+ E ++ + + ++ +K
Sbjct: 2256 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS---KNIMLEQDIAGRQSSINAMNEK 2312
Query: 2177 GEALLAQSHPR-AGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRV-DLAEA 2234
+ + + P A + +++ L + + ++E+ + +E + + + +
Sbjct: 2313 VKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2372
Query: 2235 WIQEKEVKMNVGDL-GQDLEHCLQ-LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
+++ K + D+ G+D+ Q ++ EF + V + ++ IS L
Sbjct: 2373 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL----- 2427
Query: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE----IHVLSRELDNVTKRIQEK 2348
P + ++ ++ + L+ ++ + ++ + E VL + L + K +K
Sbjct: 2428 -PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2486
Query: 2349 EALIQ----ALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA- 2403
++Q A D GK LE ++L K E+ + SL + + + A
Sbjct: 2487 VPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAA 2546
Query: 2404 ---HGLRHRQQEVA---ESWWQ------------------------LRSRAQKRREALDA 2433
G + A E +W L+ + + L
Sbjct: 2547 VKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSK 2606
Query: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
L +AQ+ + + + L + + +PAP + +E+++ +AEL + +
Sbjct: 2607 LQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE 2666
Query: 2494 ARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-HQLQL--QQALE-----LQL 2545
+ +LL R +Q L+ ++ WQE +QL + QQ LE L
Sbjct: 2667 LKDKLTELLEENPDTPEAPR-----WKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQ 2721
Query: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL----WKHKMLEWDLEVQAGKISALE 2601
F + ++++WL KE ++ G PL+ +L + ++L + + + L
Sbjct: 2722 FQTVEAQLKQWLVEKELMVSVLG---PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2778
Query: 2602 ATARGL--HQGGHPEAQSALGRCQAMLLRK-EALFRQAGTRRHRLEEL----RQLQAFLQ 2654
A +G+ G P + + A + +K ++L Q R +++ Q Q+ L+
Sbjct: 2779 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2838
Query: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQ---QQELQREGQR 2711
+ + L K +L AM QL+ Q + E+ Q Q L +
Sbjct: 2839 SLSDKLSDLDNKLSSSLAVSTHPDAM-NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA 2897
Query: 2712 LLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSMEELENWLE- 2769
L++ + +E + +LE + + +++ ++ V LQ AC + + ++ + + WL+
Sbjct: 2898 LVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2956
Query: 2770 PIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQ-AFVREGHCLAQD 2828
E + ++ + L + L+ ++ + ++ E + + + ++
Sbjct: 2957 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 3016
Query: 2829 VEEQARRLLQRFKSLREPLQERRTAL-EARSLLLKFFRDADEEMAWV---QEKL-PLAAA 2883
++ Q + + + + ++ER L E+ LK+ + W+ Q L +
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076
Query: 2884 QDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLE 2943
D + +++ L ++L+ EM H + ++ T L+ V + L
Sbjct: 3077 LDPAEGENSIAKL----KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI 3132
Query: 2944 KAMAHLRAEAARRRLLLQ-QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
+ + + + ++ L+ Q+ ++F E+ L LD D S +
Sbjct: 3133 QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY 3192
Query: 3003 LRRLEATKRDLEAFSPRIERLQQTA--ALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
L L+ ++ L+A +++ ++ A ++E+ + + VL Q++ + + H+ L ++ +
Sbjct: 3193 LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3252
Query: 3061 ARGHGLQEQLQ--------LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKF 3112
+ L+ +LQ + ++ + D L + A G+D E ++ +E
Sbjct: 3253 EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV------GRDAETLQKQKETI 3306
Query: 3113 DAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
AF K++++L + A + L P + + +EA + Q K
Sbjct: 3307 KAFLKKLEALMASNDNANKTCKMML--ATEETSPDLVGIKRDLEALSK---QCNKLLDRA 3361
Query: 3173 LAAAHEVHSFQQAAAELQGRMQEKTALM-KGEDGGHSLSSV----RTLQQQHRRL----E 3223
A +V + E +++E + L+ K E+ S V T+ QQ +
Sbjct: 3362 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3421
Query: 3224 RELEAMEKEVARLQTEACRLGQ--LHPAAPG--------GLAKVQEAWATLQAKAQERGQ 3273
E+E ++ + Q + LGQ + AA L V W TL K +R
Sbjct: 3422 EEIEPLQGK----QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAA 3477
Query: 3274 WLAQA-AQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
L +A F + LL+W + +EL ++++ + Q ++L Q + + R
Sbjct: 3478 QLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDR 3537
Query: 3333 LQAQD-LRQEGQQLVDNSH-FMSAEVTECLQELEGRLQE-LEEAWALRWQRCAESWGLQK 3389
+ +++EG+++ + ++ + L L+ R + L +A Q S Q+
Sbjct: 3538 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3597
Query: 3390 LRQRLEQAEAWLACWEGLLLKPD-YGHSVSDVELLLHRHQDLE----------------- 3431
+ LE WL E L+ + G S +E + +H+ LE
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3657
Query: 3432 ---KLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRA 3465
K+L+++E+K K + Q ++ QE R+
Sbjct: 3658 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694
Score = 93.2 bits (230), Expect = 4e-18
Identities = 244/1316 (18%), Positives = 516/1316 (39%), Gaps = 186/1316 (14%)
Query: 246 CSRLHQGQTVQRRLTKIL--------------LQLQETELLQTQYEQLVADLLRWIAEKQ 291
CS + Q+++++L K+L LQL+ + L Q+ + +L W+ E Q
Sbjct: 3991 CSE-EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 4049
Query: 292 MQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRR--- 348
+ LPA L T+ + QE+ +L++ L+ + + N+
Sbjct: 4050 SIIS------QLPA--PALEYETLRQQQEEHRQLRE------LIAEHKPHIDKMNKTGPQ 4095
Query: 349 --PFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESF 406
P EG + E + + + + +++R + L + + +F K +
Sbjct: 4096 LLELSPGEGFSIQEK---YVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQI 4149
Query: 407 LKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYH-- 464
L+ E+++++ R PP+ A VE +++ + + E + Q L E +E
Sbjct: 4150 LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME-KLQPLYETLKQRGEEMIARS 4208
Query: 465 -------SWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAV--------LSLLQEVEA 509
S V + +++ W+ + ++ + ++ D+ + +SL+ ++
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4268
Query: 510 ASHQLEELQEPARSTACGQQLAEVVELLQRH-DLLEAQVSAHGAHVSHLAQQTAELDSSL 568
+ +L++P + +Q E E ++ D L+ ++ S L E D
Sbjct: 4269 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP- 4327
Query: 569 GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV 627
+++ L SL + R LE+ +Q A ++ + W+ G ++
Sbjct: 4328 -----IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4382
Query: 628 GNAA-LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAE 686
+ + +G DL + +++ K ++E ++ Q + ++ + +L ++ + D +
Sbjct: 4383 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQ-IEMERLNHQAELLLKKVTEESDKHTVQD 4441
Query: 687 AVQGG---WQLLQTRVVGRGARLQTALLVLQYFADAA-EAASWLRERRSSL-ERASCGQD 741
+ W L+ R++ R +L+ ALL L F A E +WL L E+ G D
Sbjct: 4442 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4501
Query: 742 QAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGP 801
A E L +H L+ + A + + A++ G L
Sbjct: 4502 PKAIEIELAKHHVLQNDVLAHQSTV--------------------EAVNKAGNDLIESSA 4541
Query: 802 WSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAM 861
EAS + + L+Q ++++ + R+ +L+ A+
Sbjct: 4542 GEEAS------------------------NLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577
Query: 862 -ALFGFCSSCGELQLWL---EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAE 917
GF +LQ WL E+ + + + +T + + A + +
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4637
Query: 918 VSSSAEQLRQRYPGNS-TQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGP 976
+ +Q+ R P ++ T I + L ++W +E E+ +L E + E
Sbjct: 4638 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE---EALNLAMEFHN 4694
Query: 977 TQVQLRDVLLQLE-----ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPG 1031
+ + L Q E A +P DT Q+ + K E H + ++++++ G
Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLILDTV-LFQIDEHKVFANEVNSH--REQIIELDKTG 4751
Query: 1032 -----YAESQP---LQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQLLLW 1082
+++ Q ++ + ++Q ++V +++ +R R + + R + F + +L+ W
Sbjct: 4752 THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEW 4811
Query: 1083 AESVQAQLRSK-EVSVDVASAQRLLREHQDLLEEI---HLWQERLQQLDAQSQPMAALDC 1138
E + L S+ E++ D + L +H++ + + H + + + +L
Sbjct: 4812 LEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL-A 4870
Query: 1139 PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL 1198
D+ ++ + L L + + +RQ L+E L G+ D A WL+
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS--GQFTDALQALI----DWLYR 4924
Query: 1199 --DNLGE------DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTV 1250
L E D+ ++L+ H+ F + L +AL+ +L++ + V
Sbjct: 4925 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4984
Query: 1251 REQLQSIQAQWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWM-EEKGLMAAHEPSG 1308
+ Q+Q + +W + S ++ +L A+L Q +E+ V L++W+ E + + H
Sbjct: 4985 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 5044
Query: 1309 ARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWE 1367
+ L+TL +H+ +L R + +G +L+ C + I T W
Sbjct: 5045 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA--ICHPDSITT-----IKHWI 5097
Query: 1368 ALNRKMTERGDELQQAGQQEQLLRQ----LQDAKEQLEQLEGALQSSETGQDLRSSQRLQ 1423
+ R E + L A Q +Q L L +E LE L LQ +ET + + +
Sbjct: 5098 TIIRARFE--EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5155
Query: 1424 KRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRL---ELLQGHLAI 1476
Q++E +A + M P + + T+ + RR LQ H+ +
Sbjct: 5156 ---QEIEEVKALIAEHQTFMEEMTR---KQPDVDKVTKTYKRRAADPSSLQSHIPV 5205
Score = 58.5 bits (140), Expect = 1e-07
Identities = 60/287 (20%), Positives = 117/287 (40%), Gaps = 18/287 (6%)
Query: 1381 QQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL-----ESESRT 1435
Q ++E ++ +QD +++++ L +E G DL S + + H+ + E ES
Sbjct: 774 QNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL 833
Query: 1436 LAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLS 1494
AK++ + A P L +K L RLE L + ++ LH F +
Sbjct: 834 KEAKISEIQMTA------PLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 886
Query: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
EL W+ E ++E H EL E+ + ++ V L
Sbjct: 887 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 946
Query: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
HP I ++ W+ + + C+ Q +++ + ++F D E ++ + +
Sbjct: 947 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 1006
Query: 1615 SSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTL 1657
R Y D ++++ L+ + +EEL Y S++ L A+T+
Sbjct: 1007 -QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 1052
Score = 57.0 bits (136), Expect = 3e-07
Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 56/470 (11%)
Query: 209 VAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQLQE 268
V E + + +LL+ P + ++T + + ++L T+ R+ +L+E
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL----TIDRQQ-----KLEE 2714
Query: 269 TELLQTQYEQLVADLLRWIAEKQMQLEARD----FPDSLPAMRQLLAAFTIFRTQEKPPR 324
+ TQ++ + A L +W+ EK++ + P+ L RQ + KP
Sbjct: 2715 SSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY 2774
Query: 325 LQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLL 384
Q A + +L R + + R + + LA ++Q W L + R + Q ++
Sbjct: 2775 EQLTAAGQGILSR---PGEDPSLRGIVKEQ---LAAVTQKWDSLTGQLSDRCDWIDQAIV 2828
Query: 385 QLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQ 444
+ + ++L R K + ++ L + V A L T + Q + + I
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888
Query: 445 EGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLL 504
QAL E L +E+Y A+++R+ E + ++ + Q + + L
Sbjct: 2889 ----QALCEDLSALVKEEYLK-AELSRQLEGILKSFKDVEQKAENH----------VQHL 2933
Query: 505 QEVEAASHQLEEL------------QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGA 552
Q A+SHQ +++ +E +S +L + L++ H ++A
Sbjct: 2934 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-- 2991
Query: 553 HVSHLAQQTAELDSSL-----GTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA 607
SH+ ++T +L G+ LQ + T+ + V+ R L+++L++A
Sbjct: 2992 --SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 3049
Query: 608 -EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRH 656
++ E W+ +C + D ++ ++ K K+L+ E+ +H
Sbjct: 3050 LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQH 3099
Score = 40.4 bits (93), Expect = 0.032
Identities = 55/296 (18%), Positives = 119/296 (40%), Gaps = 33/296 (11%)
Query: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLH 3247
+L + E + + G L SV + + H+ + R +E E + + ++ ++
Sbjct: 788 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSL-----KEAKISEIQ 842
Query: 3248 PAAPGGLA------KVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQEL 3301
AP L +++ +A L ++ + + L H F+ R L W E++E
Sbjct: 843 MTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELIWLNEKEEE 899
Query: 3302 ASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ 3361
+ + +E + H EL +E+ + + +++ +QL+ +H A +T
Sbjct: 900 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH--PARLT---- 953
Query: 3362 ELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVE 3421
+E ++ W+ Q C Q + Q +++ A+ + DY ++ D
Sbjct: 954 -IEAYRAAMQTQWSWILQLC------QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA- 1005
Query: 3422 LLLHRHQDLEKLLAAQEEKFAQMQKTEMEQ-ELLLQPQELKPGRAGSSLTSFQWRP 3476
+ R ++ ++ K + + ME+ E LLQ + G + T Q +P
Sbjct: 1006 --IQRKYSCDR--SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKP 1057
Score = 40.0 bits (92), Expect = 0.042
Identities = 43/193 (22%), Positives = 76/193 (39%), Gaps = 20/193 (10%)
Query: 1077 QQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
Q LL W + +Q QL E D+ S + L H+++ I ++ L++ M A
Sbjct: 787 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA- 845
Query: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWL 1196
P L L + Q K+L R Q ++ + F + N WL
Sbjct: 846 --PLKLTYAEKLHRL--ESQYAKLLNTSRNQ--------ERHLDTLHNFVSRATNELIWL 893
Query: 1197 HL---DNLGEDVREALSLLQQ----HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
+ + + D E + + + H E R L ++++ E+L+ HPA T
Sbjct: 894 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT 953
Query: 1250 VREQLQSIQAQWT 1262
+ ++Q QW+
Sbjct: 954 IEAYRAAMQTQWS 966
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 132,236,185
Number of Sequences: 37866
Number of extensions: 5922558
Number of successful extensions: 44898
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 835
Number of HSP's that attempted gapping in prelim test: 25575
Number of HSP's gapped (non-prelim): 10060
length of query: 3639
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3517
effective length of database: 13,627,866
effective search space: 47929204722
effective search space used: 47929204722
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.