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Search of human proteins with 16975496
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16975496 cortactin binding protein 2 [Homo sapiens]
(1663 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16975496 cortactin binding protein 2 [Homo sapiens] 3327 0.0
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 384 e-106
gi|239750047 PREDICTED: similar to neuron navigator 2, partial [... 119 2e-26
gi|161169017 neuron navigator 2 isoform 4 [Homo sapiens] 119 2e-26
gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens] 119 2e-26
gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens] 119 2e-26
gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens] 119 2e-26
gi|169218146 PREDICTED: similar to neuron navigator 3, partial [... 115 5e-25
gi|120953251 neuron navigator 3 [Homo sapiens] 115 5e-25
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 110 9e-24
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 110 9e-24
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 110 9e-24
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 107 1e-22
gi|239747580 PREDICTED: similar to NAV1 protein [Homo sapiens] 106 2e-22
gi|27262622 neuron navigator 1 [Homo sapiens] 106 2e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 105 5e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 105 5e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 105 5e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 105 5e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 105 5e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 105 5e-22
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 103 1e-21
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 100 1e-20
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 100 1e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 100 2e-20
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 99 4e-20
gi|30348954 mindbomb homolog 1 [Homo sapiens] 98 6e-20
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 98 6e-20
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 98 8e-20
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 97 1e-19
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 3327 bits (8627), Expect = 0.0
Identities = 1663/1663 (100%), Positives = 1663/1663 (100%)
Query: 1 MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIE 60
MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIE
Sbjct: 1 MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIE 60
Query: 61 ALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKK 120
ALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKK
Sbjct: 61 ALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKK 120
Query: 121 MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ 180
MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ
Sbjct: 121 MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ 180
Query: 181 LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQ 240
LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQ
Sbjct: 181 LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQ 240
Query: 241 LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGT 300
LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGT
Sbjct: 241 LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGT 300
Query: 301 VTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQA 360
VTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQA
Sbjct: 301 VTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQA 360
Query: 361 SYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNS 420
SYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNS
Sbjct: 361 SYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNS 420
Query: 421 QAPPMHSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRD 480
QAPPMHSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRD
Sbjct: 421 QAPPMHSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRD 480
Query: 481 NLVAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRG 540
NLVAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRG
Sbjct: 481 NLVAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRG 540
Query: 541 NPPPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINE 600
NPPPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINE
Sbjct: 541 NPPPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINE 600
Query: 601 ENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPT 660
ENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPT
Sbjct: 601 ENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPT 660
Query: 661 TIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQ 720
TIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQ
Sbjct: 661 TIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQ 720
Query: 721 GNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTP 780
GNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTP
Sbjct: 721 GNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTP 780
Query: 781 LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT 840
LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT
Sbjct: 781 LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT 840
Query: 841 TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV 900
TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV
Sbjct: 841 TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV 900
Query: 901 VPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKH 960
VPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKH
Sbjct: 901 VPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKH 960
Query: 961 LLENLNALKIPLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNH 1020
LLENLNALKIPLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNH
Sbjct: 961 LLENLNALKIPLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNH 1020
Query: 1021 FQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNK 1080
FQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNK
Sbjct: 1021 FQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNK 1080
Query: 1081 AEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQL 1140
AEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQL
Sbjct: 1081 AEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQL 1140
Query: 1141 ALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENL 1200
ALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENL
Sbjct: 1141 ALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENL 1200
Query: 1201 EKSSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLL 1260
EKSSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLL
Sbjct: 1201 EKSSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLL 1260
Query: 1261 VQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNS 1320
VQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNS
Sbjct: 1261 VQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNS 1320
Query: 1321 CLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQP 1380
CLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQP
Sbjct: 1321 CLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQP 1380
Query: 1381 GFGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVS 1440
GFGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVS
Sbjct: 1381 GFGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVS 1440
Query: 1441 SYNTCNKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASL 1500
SYNTCNKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASL
Sbjct: 1441 SYNTCNKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASL 1500
Query: 1501 SKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFD 1560
SKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFD
Sbjct: 1501 SKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFD 1560
Query: 1561 SSGNNPVLSATINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKV 1620
SSGNNPVLSATINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKV
Sbjct: 1561 SSGNNPVLSATINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKV 1620
Query: 1621 TQCSQNTKRSSSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK 1663
TQCSQNTKRSSSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK
Sbjct: 1621 TQCSQNTKRSSSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK 1663
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 384 bits (985), Expect = e-106
Identities = 259/654 (39%), Positives = 347/654 (53%), Gaps = 94/654 (14%)
Query: 32 DVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDY 91
+++ LSK EL L S++EGELEARDLVIEAL+A+ ++ FI+ERYG++N++DP +ALQRD+
Sbjct: 2 NLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDF 61
Query: 92 EA--GAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKK----------- 138
E D EK+PVCTNPLSIL+ VM CK MQERM +QLAAAESR +K
Sbjct: 62 ETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQR 121
Query: 139 -------------------------LEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLM 173
LE EK Q++ E+E KKL+++LEEER ++KQ+ M
Sbjct: 122 HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSM 181
Query: 174 LVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSE 233
LV ECK+ + K EE QK ++ KLE+EK + ++LEEEL+AE++R + EAQ+EKQLSE
Sbjct: 182 LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSE 241
Query: 234 FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRG-SDSKPSLSLPRKTKDRRLVS 292
FD EREQLRAKLNREE T LKEE++ ++K+++ L+ S P+ L + VS
Sbjct: 242 FDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV----TVS 297
Query: 293 ISVGTEGTVTRSVACQTDLVTENADHMKKL-PLTMPVKPSTGSPLVSANAKGSVCTSATM 351
TE + SV CQT+ H + +T P +P S C
Sbjct: 298 KGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQ 357
Query: 352 ARPGIDRQASYGDLIGASVPAFPPPSA---NKIEENGPSTGSTPDPTSSTPPLPSNA--- 405
R+ + G+ + VP A K ENG P PL S+
Sbjct: 358 T----TRELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSL 413
Query: 406 APPTAQTPGIAPQNSQAPPM------HSLHSPCANTSLHPGLNPRIQAARFRFQGNANDP 459
+P + + + +P + S SP +S G+N R AAR +FQ A D
Sbjct: 414 SPSSTASSSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQA-DQ 472
Query: 460 DQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPSRPGVP------ 513
DQ + QSPPSRD+SPT DN AKQLARNTVTQ LSRFTS Q P +P P
Sbjct: 473 DQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQ--GPIKPVSPNSSPFG 530
Query: 514 -----------PTGDVGTHPPVGRTS---------LKTHGVARVDRGNPPPIPPKKPGLS 553
P GD P G+ S +K+ + R +RGNPPPIPPKKPGL+
Sbjct: 531 TDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLT 590
Query: 554 QTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSS 607
+PS P K S+A++ D + S+ + + G V E LP SS
Sbjct: 591 PSPSATTPLTKT---HSQAASLTTAEDLASSCSSNTVVANGKDV--ELLLPTSS 639
>gi|239750047 PREDICTED: similar to neuron navigator 2, partial [Homo
sapiens]
Length = 453
Score = 119 bits (298), Expect = 2e-26
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1043 SNIGLSARSIRSITLGNVPWS-VGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTY 1101
S +GL++ S+ ++G + S ++ P ++ I+V + G E L S+ +
Sbjct: 38 SQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTT-ISVTVKGLAENSLDSLVF 96
Query: 1102 ASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAE 1161
S+IP ++Q Y+ L+ ++ +I GP G+ + Y+ ++L+ + R+ I
Sbjct: 97 ESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN 156
Query: 1162 VDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEK-SSLSELLRDFLAPLENRS 1220
VD SKE L + A + + ++IIL+NL SSL E+
Sbjct: 157 VDHKSSKE-LRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIF----------- 204
Query: 1221 TESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGL 1280
NGL C Y H+ +++GT+ +A +L + +FRWV EP++G
Sbjct: 205 ----------NGLLNCKY-HKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGF 253
Query: 1281 LQRFLRRKVV-NKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLS 1339
L RFLRRK++ + G+ + + KI+DW VW LN L + + +GP+ FLS
Sbjct: 254 LGRFLRRKLMETEISGRVRNM--ELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLS 311
Query: 1340 CPVVPGHAQVTVKWMSKLWNGVIAPRVQEAI 1370
CP+ ++V W + LWN I P + EA+
Sbjct: 312 CPIDVDGSRV---WFTDLWNYSIIPYLLEAV 339
>gi|161169017 neuron navigator 2 isoform 4 [Homo sapiens]
Length = 1493
Score = 119 bits (298), Expect = 2e-26
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1043 SNIGLSARSIRSITLGNVPWS-VGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTY 1101
S +GL++ S+ ++G + S ++ P ++ I+V + G E L S+ +
Sbjct: 1078 SQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTT-ISVTVKGLAENSLDSLVF 1136
Query: 1102 ASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAE 1161
S+IP ++Q Y+ L+ ++ +I GP G+ + Y+ ++L+ + R+ I
Sbjct: 1137 ESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN 1196
Query: 1162 VDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEK-SSLSELLRDFLAPLENRS 1220
VD SKE L + A + + ++IIL+NL SSL E+
Sbjct: 1197 VDHKSSKE-LRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIF----------- 1244
Query: 1221 TESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGL 1280
NGL C Y H+ +++GT+ +A +L + +FRWV EP++G
Sbjct: 1245 ----------NGLLNCKY-HKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGF 1293
Query: 1281 LQRFLRRKVV-NKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLS 1339
L RFLRRK++ + G+ + + KI+DW VW LN L + + +GP+ FLS
Sbjct: 1294 LGRFLRRKLMETEISGRVRNM--ELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLS 1351
Query: 1340 CPVVPGHAQVTVKWMSKLWNGVIAPRVQEAI 1370
CP+ ++V W + LWN I P + EA+
Sbjct: 1352 CPIDVDGSRV---WFTDLWNYSIIPYLLEAV 1379
Score = 33.5 bits (75), Expect = 1.8
Identities = 78/375 (20%), Positives = 132/375 (35%), Gaps = 62/375 (16%)
Query: 376 PSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTP--GIAPQNSQAPPMHSLHS--- 430
P A++++ + PS S PLPS++ PTA G Q+ A + + +
Sbjct: 168 PKASQVKRS-PSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGV 226
Query: 431 PCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLA-- 488
+ S G P+ A R G + D Q+ ++ +SR NL + L
Sbjct: 227 TVTSRSATLGKIPKSSALVSRSAGRKSSMD----GAQNQDDGYLALSSRTNLQYRSLPRP 282
Query: 489 -----------RNTVTQALSRFTSPQAGAP--------------SRPGVPPTGDVGTHPP 523
R++ + S +S AG P S PG+ D
Sbjct: 283 SKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGIS 342
Query: 524 VGRTSLKTHGVARVDRGNPPPIPPKKPGL---SQTPSPPHPQLKVIIDSSRASN----TG 576
S+ + +V+ P P + L ++ P P L+ + T
Sbjct: 343 SDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATA 402
Query: 577 AKVDNKTVASTPSSL---------PQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCA 627
+ N V S P + P G+ V++ SSSP ++DL +P +
Sbjct: 403 ENMKNSVVISNPHATMTQQGNLDSPSGSGVLSS----GSSSPLY--SKNVDLNQSPLASS 456
Query: 628 VSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAF---CSSINPVSASSCRPGASDSL 684
S+ ++ + T + A S L + + C SI+ +S P + S
Sbjct: 457 PSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSST 516
Query: 685 LVTASGWSPSLTPLL 699
+ AS SLTP +
Sbjct: 517 GLIASSKDDSLTPFV 531
>gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens]
Length = 2365
Score = 119 bits (298), Expect = 2e-26
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1043 SNIGLSARSIRSITLGNVPWS-VGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTY 1101
S +GL++ S+ ++G + S ++ P ++ I+V + G E L S+ +
Sbjct: 1950 SQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTT-ISVTVKGLAENSLDSLVF 2008
Query: 1102 ASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAE 1161
S+IP ++Q Y+ L+ ++ +I GP G+ + Y+ ++L+ + R+ I
Sbjct: 2009 ESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN 2068
Query: 1162 VDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEK-SSLSELLRDFLAPLENRS 1220
VD SKE L + A + + ++IIL+NL SSL E+
Sbjct: 2069 VDHKSSKE-LRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIF----------- 2116
Query: 1221 TESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGL 1280
NGL C Y H+ +++GT+ +A +L + +FRWV EP++G
Sbjct: 2117 ----------NGLLNCKY-HKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGF 2165
Query: 1281 LQRFLRRKVV-NKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLS 1339
L RFLRRK++ + G+ + + KI+DW VW LN L + + +GP+ FLS
Sbjct: 2166 LGRFLRRKLMETEISGRVRNM--ELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLS 2223
Query: 1340 CPVVPGHAQVTVKWMSKLWNGVIAPRVQEAI 1370
CP+ ++V W + LWN I P + EA+
Sbjct: 2224 CPIDVDGSRV---WFTDLWNYSIIPYLLEAV 2251
Score = 34.3 bits (77), Expect = 1.0
Identities = 81/395 (20%), Positives = 137/395 (34%), Gaps = 62/395 (15%)
Query: 376 PSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTP--GIAPQNSQAPPMHSLHS--- 430
P A++++ + PS S PLPS++ PTA G Q+ A + + +
Sbjct: 1018 PKASQVKRS-PSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGV 1076
Query: 431 PCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLA-- 488
+ S G P+ A R G + D Q+ ++ +SR NL + L
Sbjct: 1077 TVTSRSATLGKIPKSSALVSRSAGRKSSMD----GAQNQDDGYLALSSRTNLQYRSLPRP 1132
Query: 489 -----------RNTVTQALSRFTSPQAGAP--------------SRPGVPPTGDVGTHPP 523
R++ + S +S AG P S PG+ D
Sbjct: 1133 SKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGIS 1192
Query: 524 VGRTSLKTHGVARVDRGNPPPIPPKKPGL---SQTPSPPHPQLKVIIDSSRASN----TG 576
S+ + +V+ P P + L ++ P P L+ + T
Sbjct: 1193 SDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATA 1252
Query: 577 AKVDNKTVASTPSSL---------PQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCA 627
+ N V S P + P G+ V++ SSSP ++DL +P +
Sbjct: 1253 ENMKNSVVISNPHATMTQQGNLDSPSGSGVLSS----GSSSPLY--SKNVDLNQSPLASS 1306
Query: 628 VSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAF---CSSINPVSASSCRPGASDSL 684
S+ ++ + T + A S L + + C SI+ +S P + S
Sbjct: 1307 PSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSST 1366
Query: 685 LVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAA 719
+ AS SLTP + + L AA+
Sbjct: 1367 GLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAAS 1401
>gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens]
Length = 2432
Score = 119 bits (298), Expect = 2e-26
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1043 SNIGLSARSIRSITLGNVPWS-VGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTY 1101
S +GL++ S+ ++G + S ++ P ++ I+V + G E L S+ +
Sbjct: 2017 SQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTT-ISVTVKGLAENSLDSLVF 2075
Query: 1102 ASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAE 1161
S+IP ++Q Y+ L+ ++ +I GP G+ + Y+ ++L+ + R+ I
Sbjct: 2076 ESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN 2135
Query: 1162 VDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEK-SSLSELLRDFLAPLENRS 1220
VD SKE L + A + + ++IIL+NL SSL E+
Sbjct: 2136 VDHKSSKE-LRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIF----------- 2183
Query: 1221 TESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGL 1280
NGL C Y H+ +++GT+ +A +L + +FRWV EP++G
Sbjct: 2184 ----------NGLLNCKY-HKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGF 2232
Query: 1281 LQRFLRRKVV-NKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLS 1339
L RFLRRK++ + G+ + + KI+DW VW LN L + + +GP+ FLS
Sbjct: 2233 LGRFLRRKLMETEISGRVRNM--ELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLS 2290
Query: 1340 CPVVPGHAQVTVKWMSKLWNGVIAPRVQEAI 1370
CP+ ++V W + LWN I P + EA+
Sbjct: 2291 CPIDVDGSRV---WFTDLWNYSIIPYLLEAV 2318
Score = 34.3 bits (77), Expect = 1.0
Identities = 81/395 (20%), Positives = 137/395 (34%), Gaps = 62/395 (15%)
Query: 376 PSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTP--GIAPQNSQAPPMHSLHS--- 430
P A++++ + PS S PLPS++ PTA G Q+ A + + +
Sbjct: 1082 PKASQVKRS-PSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGV 1140
Query: 431 PCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLA-- 488
+ S G P+ A R G + D Q+ ++ +SR NL + L
Sbjct: 1141 TVTSRSATLGKIPKSSALVSRSAGRKSSMD----GAQNQDDGYLALSSRTNLQYRSLPRP 1196
Query: 489 -----------RNTVTQALSRFTSPQAGAP--------------SRPGVPPTGDVGTHPP 523
R++ + S +S AG P S PG+ D
Sbjct: 1197 SKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGIS 1256
Query: 524 VGRTSLKTHGVARVDRGNPPPIPPKKPGL---SQTPSPPHPQLKVIIDSSRASN----TG 576
S+ + +V+ P P + L ++ P P L+ + T
Sbjct: 1257 SDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATA 1316
Query: 577 AKVDNKTVASTPSSL---------PQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCA 627
+ N V S P + P G+ V++ SSSP ++DL +P +
Sbjct: 1317 ENMKNSVVISNPHATMTQQGNLDSPSGSGVLSS----GSSSPLY--SKNVDLNQSPLASS 1370
Query: 628 VSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAF---CSSINPVSASSCRPGASDSL 684
S+ ++ + T + A S L + + C SI+ +S P + S
Sbjct: 1371 PSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSST 1430
Query: 685 LVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAA 719
+ AS SLTP + + L AA+
Sbjct: 1431 GLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAAS 1465
>gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens]
Length = 2429
Score = 119 bits (298), Expect = 2e-26
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1043 SNIGLSARSIRSITLGNVPWS-VGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTY 1101
S +GL++ S+ ++G + S ++ P ++ I+V + G E L S+ +
Sbjct: 2014 SQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTT-ISVTVKGLAENSLDSLVF 2072
Query: 1102 ASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAE 1161
S+IP ++Q Y+ L+ ++ +I GP G+ + Y+ ++L+ + R+ I
Sbjct: 2073 ESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN 2132
Query: 1162 VDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEK-SSLSELLRDFLAPLENRS 1220
VD SKE L + A + + ++IIL+NL SSL E+
Sbjct: 2133 VDHKSSKE-LRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIF----------- 2180
Query: 1221 TESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGL 1280
NGL C Y H+ +++GT+ +A +L + +FRWV EP++G
Sbjct: 2181 ----------NGLLNCKY-HKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGF 2229
Query: 1281 LQRFLRRKVV-NKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLS 1339
L RFLRRK++ + G+ + + KI+DW VW LN L + + +GP+ FLS
Sbjct: 2230 LGRFLRRKLMETEISGRVRNM--ELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLS 2287
Query: 1340 CPVVPGHAQVTVKWMSKLWNGVIAPRVQEAI 1370
CP+ ++V W + LWN I P + EA+
Sbjct: 2288 CPIDVDGSRV---WFTDLWNYSIIPYLLEAV 2315
Score = 34.3 bits (77), Expect = 1.0
Identities = 81/395 (20%), Positives = 137/395 (34%), Gaps = 62/395 (15%)
Query: 376 PSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTP--GIAPQNSQAPPMHSLHS--- 430
P A++++ + PS S PLPS++ PTA G Q+ A + + +
Sbjct: 1082 PKASQVKRS-PSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGV 1140
Query: 431 PCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLA-- 488
+ S G P+ A R G + D Q+ ++ +SR NL + L
Sbjct: 1141 TVTSRSATLGKIPKSSALVSRSAGRKSSMD----GAQNQDDGYLALSSRTNLQYRSLPRP 1196
Query: 489 -----------RNTVTQALSRFTSPQAGAP--------------SRPGVPPTGDVGTHPP 523
R++ + S +S AG P S PG+ D
Sbjct: 1197 SKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGIS 1256
Query: 524 VGRTSLKTHGVARVDRGNPPPIPPKKPGL---SQTPSPPHPQLKVIIDSSRASN----TG 576
S+ + +V+ P P + L ++ P P L+ + T
Sbjct: 1257 SDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATA 1316
Query: 577 AKVDNKTVASTPSSL---------PQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCA 627
+ N V S P + P G+ V++ SSSP ++DL +P +
Sbjct: 1317 ENMKNSVVISNPHATMTQQGNLDSPSGSGVLSS----GSSSPLY--SKNVDLNQSPLASS 1370
Query: 628 VSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAF---CSSINPVSASSCRPGASDSL 684
S+ ++ + T + A S L + + C SI+ +S P + S
Sbjct: 1371 PSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSST 1430
Query: 685 LVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAA 719
+ AS SLTP + + L AA+
Sbjct: 1431 GLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAAS 1465
>gi|169218146 PREDICTED: similar to neuron navigator 3, partial [Homo
sapiens]
Length = 733
Score = 115 bits (287), Expect = 5e-25
Identities = 107/446 (23%), Positives = 190/446 (42%), Gaps = 56/446 (12%)
Query: 952 DVATDDCKHLLENLNALKIPLRISVGEIEPSNYG--SDDLECENTICALNIRKQTSWDDF 1009
D+ DD + + + + +S+ + YG D I ++ + +T WD
Sbjct: 246 DILLDDAGDATGHKDGRSVKIIVSISK----GYGRAKDQKSQAYLIGSIGVSGKTKWDVL 301
Query: 1010 SKAVSQALTNHFQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFA 1069
+ + + I T +++GLS+ I S +G++ S
Sbjct: 302 DGVIRRLFKEYVFRID---------------TSTSLGLSSDCIASYCIGDLIRSHNLEVP 346
Query: 1070 QS-PWDFMRKNKAEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGP 1128
+ P ++ + ITV L G +E L S + ++IP + Q Y L+ ++H +I GP
Sbjct: 347 ELLPCGYLVGDN-NIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGP 405
Query: 1129 EGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSP 1188
G+ + Y+ ++LA + + I VD SKE L + A +
Sbjct: 406 SGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKE-LQQYLANLAEQCSADNNG 464
Query: 1189 SKKKIIIILENLEK-SSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMG 1247
+ ++IIL+NL SLS++ FL C + K C Y ++G
Sbjct: 465 VELPVVIILDNLHHVGSLSDIFNGFL----------NCKYNK------CPY------IIG 502
Query: 1248 TIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKI 1307
T+ + +L + +FRWV EP++G L R+LRRK++ + + + + + KI
Sbjct: 503 TMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLI-EIEIERNIRNNDLVKI 561
Query: 1308 VDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQ 1367
+DW W LNS L + + +GP+ FL CP+ ++V W LWN + P +
Sbjct: 562 IDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRV---WFMDLWNYSLVPYIL 618
Query: 1368 EAILSRASVKRQPGFGQTTAKRHPSQ 1393
EA+ + +G+ T PS+
Sbjct: 619 EAVREGLQM-----YGKRTPWEDPSK 639
>gi|120953251 neuron navigator 3 [Homo sapiens]
Length = 2363
Score = 115 bits (287), Expect = 5e-25
Identities = 107/446 (23%), Positives = 190/446 (42%), Gaps = 56/446 (12%)
Query: 952 DVATDDCKHLLENLNALKIPLRISVGEIEPSNYG--SDDLECENTICALNIRKQTSWDDF 1009
D+ DD + + + + +S+ + YG D I ++ + +T WD
Sbjct: 1876 DILLDDAGDATGHKDGRSVKIIVSISK----GYGRAKDQKSQAYLIGSIGVSGKTKWDVL 1931
Query: 1010 SKAVSQALTNHFQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFA 1069
+ + + I T +++GLS+ I S +G++ S
Sbjct: 1932 DGVIRRLFKEYVFRID---------------TSTSLGLSSDCIASYCIGDLIRSHNLEVP 1976
Query: 1070 QS-PWDFMRKNKAEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGP 1128
+ P ++ + ITV L G +E L S + ++IP + Q Y L+ ++H +I GP
Sbjct: 1977 ELLPCGYLVGDN-NIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGP 2035
Query: 1129 EGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSP 1188
G+ + Y+ ++LA + + I VD SKE L + A +
Sbjct: 2036 SGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKE-LQQYLANLAEQCSADNNG 2094
Query: 1189 SKKKIIIILENLEK-SSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMG 1247
+ ++IIL+NL SLS++ FL C + K C Y ++G
Sbjct: 2095 VELPVVIILDNLHHVGSLSDIFNGFL----------NCKYNK------CPY------IIG 2132
Query: 1248 TIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKI 1307
T+ + +L + +FRWV EP++G L R+LRRK++ + + + + + KI
Sbjct: 2133 TMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLI-EIEIERNIRNNDLVKI 2191
Query: 1308 VDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQ 1367
+DW W LNS L + + +GP+ FL CP+ ++V W LWN + P +
Sbjct: 2192 IDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRV---WFMDLWNYSLVPYIL 2248
Query: 1368 EAILSRASVKRQPGFGQTTAKRHPSQ 1393
EA+ + +G+ T PS+
Sbjct: 2249 EAVREGLQM-----YGKRTPWEDPSK 2269
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 110 bits (276), Expect = 9e-24
Identities = 73/227 (32%), Positives = 119/227 (52%), Gaps = 13/227 (5%)
Query: 716 QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK 775
+AA GN+ + L + G+DIN ++G +AL+ AAK GH V+ LL + V++A K
Sbjct: 16 RAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 776 NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN 835
G T L A+ G E V++L+ ANIN + G TPLY+A + + + +K LLE G N
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 836 RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPAHGNSFNEEESESSVFDLDGG 889
+S T DG+TP+ A+ G+ ++ +L+ + R+PA + +++++S+ L
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 194
Query: 890 EESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ V ++N G+T HIAA G N +L G
Sbjct: 195 HNA------DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235
Score = 94.7 bits (234), Expect = 6e-19
Identities = 70/226 (30%), Positives = 109/226 (48%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T + AA G++ ++ +LL + G + + G +AL+ AA+ G + VR LL A V+
Sbjct: 412 TPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + TPL A+ G E V+LL+ + A+ + A G TPL+++ + G + +LLE
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
AG S+ T G+TP+H A G++D KLL+ R A N D +
Sbjct: 531 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590
Query: 892 SPEGISKPVVPADLINHAN-REGWTAAHIAASKGFKNCLEILCRHG 936
+ + K P HA + G+T HIAA K L +G
Sbjct: 591 ALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYG 631
Score = 94.0 bits (232), Expect = 1e-18
Identities = 67/225 (29%), Positives = 110/225 (48%), Gaps = 5/225 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA GNV + ++LLN G ++++ +G + L+ A+K G+T+ V+LLL Q++
Sbjct: 214 TPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A ++G TPL AA GH + VELL+ A + G +PL++A + + EC+K LL+
Sbjct: 273 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
T D T +H A G+ KLL+ R + + N + + +
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN----GFTPLHIACKKN 388
Query: 892 SPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ + V I G T H+AA G N + +L ++G
Sbjct: 389 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 433
Score = 94.0 bits (232), Expect = 1e-18
Identities = 63/207 (30%), Positives = 101/207 (48%), Gaps = 4/207 (1%)
Query: 672 SASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSM 728
+A S L V A + + LL+ G +P A T L AA + + + S
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 626
Query: 729 LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG 788
LLN G + N + G + L+ A++ GHTD V LLL A ++ + K+G T L AA +
Sbjct: 627 LLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Query: 789 HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH 848
++L + A+ + G TPL +AC GN + + LL+ G N + KT +G+TP+H
Sbjct: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 745
Query: 849 AAVDTGNVDSLKLLMYHRIPAHGNSFN 875
A G+ + +L+ H + + N
Sbjct: 746 QAAQQGHTHIINVLLQHGAKPNATTAN 772
Score = 90.1 bits (222), Expect = 2e-17
Identities = 70/254 (27%), Positives = 113/254 (44%), Gaps = 30/254 (11%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L +A +G V + S+LL E G + + + G + L+ AAK G D +LLL A +
Sbjct: 511 TPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+A KNG TPL AA + + LL+ A+ + A G TPL++A K + LL
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNS--------FNEEESESSV 883
G ++ T G TP+H A G+ D + LL+ H ++ +E + +V
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689
Query: 884 FDL------DGGEESPEGISKPVVPADL---------------INHANREGWTAAHIAAS 922
D+ D + G + +V +N + G+T H AA
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 749
Query: 923 KGFKNCLEILCRHG 936
+G + + +L +HG
Sbjct: 750 QGHTHIINVLLQHG 763
Score = 87.4 bits (215), Expect = 1e-16
Identities = 75/275 (27%), Positives = 117/275 (42%), Gaps = 40/275 (14%)
Query: 696 TPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
T LL G R T L A+ +GN ++ +LL+ G I+ DG + L+ AA+
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAAR 287
Query: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE------------------- 794
+GH V LLL A + A KNG +PL AA H ECV+
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Query: 795 --------------LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT 840
LL+ AN N A G TPL++ACK + ++LL++ G + T
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
Query: 841 TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV 900
G TP+H A G+++ + LL+ + + E + + E + +
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE----TALHMAARAGQVEVVRCLL 463
Query: 901 VPADLINHANREGWTAAHIAASKGFKNCLEILCRH 935
L++ RE T HIA+ G +++L +H
Sbjct: 464 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 86.3 bits (212), Expect = 2e-16
Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 4/200 (2%)
Query: 737 INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL 796
+N + E G + L+ AA G+ + LLL+ A V+ +NG TPL A+ +G+ V+LL
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 797 ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV 856
+ I+ G TPL+ A ++G+ + ++LLLE G +T +G +P+H A +V
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 857 DSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTA 916
+ +K L+ H+ P + + + + + K P N G+T
Sbjct: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTP 380
Query: 917 AHIAASKGFKNCLEILCRHG 936
HIA K +E+L ++G
Sbjct: 381 LHIACKKNRIKVMELLVKYG 400
Score = 81.6 bits (200), Expect = 6e-15
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 38/194 (19%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-- 769
T L AA + ++ ++ LL E G + + + EDG + L A + GH V +LL + +
Sbjct: 111 TPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169
Query: 770 -----------------------------------VNAADKNGFTPLCAAAAQGHFECVE 794
VN ++GFTPL AA G+
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229
Query: 795 LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
LL++ A ++ A G TPL++A K GN +KLLL+ G KT DG TP+H A +G
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 289
Query: 855 NVDSLKLLMYHRIP 868
+ ++LL+ P
Sbjct: 290 HDQVVELLLERGAP 303
Score = 73.6 bits (179), Expect = 2e-12
Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 4/154 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +G+ ++++LL ++G +I+ S + G ++L+ AA+ + +L A +
Sbjct: 643 TPLHLASQEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A K G+TPL A G+ + V L+ AN+N G TPL+ A + G+ I +LL+
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL 862
G + T +G T + A G VD+LK++
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 795
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + + ++ +L+ + G I E G + ++ AA GH + V LLL A +
Sbjct: 379 TPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ G T L AA G E V L+ A ++ A QTPL++A + G E ++LLL+
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
+ TT+G+TP+H + G VD +L+
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLL 529
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 110 bits (276), Expect = 9e-24
Identities = 73/227 (32%), Positives = 119/227 (52%), Gaps = 13/227 (5%)
Query: 716 QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK 775
+AA GN+ + L + G+DIN ++G +AL+ AAK GH V+ LL + V++A K
Sbjct: 37 RAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 776 NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN 835
G T L A+ G E V++L+ ANIN + G TPLY+A + + + +K LLE G N
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 836 RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPAHGNSFNEEESESSVFDLDGG 889
+S T DG+TP+ A+ G+ ++ +L+ + R+PA + +++++S+ L
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 890 EESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ V ++N G+T HIAA G N +L G
Sbjct: 216 HNA------DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Score = 94.7 bits (234), Expect = 6e-19
Identities = 70/226 (30%), Positives = 109/226 (48%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T + AA G++ ++ +LL + G + + G +AL+ AA+ G + VR LL A V+
Sbjct: 433 TPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + TPL A+ G E V+LL+ + A+ + A G TPL+++ + G + +LLE
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
AG S+ T G+TP+H A G++D KLL+ R A N D +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 892 SPEGISKPVVPADLINHAN-REGWTAAHIAASKGFKNCLEILCRHG 936
+ + K P HA + G+T HIAA K L +G
Sbjct: 612 ALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Score = 94.0 bits (232), Expect = 1e-18
Identities = 67/225 (29%), Positives = 110/225 (48%), Gaps = 5/225 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA GNV + ++LLN G ++++ +G + L+ A+K G+T+ V+LLL Q++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A ++G TPL AA GH + VELL+ A + G +PL++A + + EC+K LL+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
T D T +H A G+ KLL+ R + + N + + +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN----GFTPLHIACKKN 409
Query: 892 SPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ + V I G T H+AA G N + +L ++G
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Score = 94.0 bits (232), Expect = 1e-18
Identities = 63/207 (30%), Positives = 101/207 (48%), Gaps = 4/207 (1%)
Query: 672 SASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSM 728
+A S L V A + + LL+ G +P A T L AA + + + S
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 729 LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG 788
LLN G + N + G + L+ A++ GHTD V LLL A ++ + K+G T L AA +
Sbjct: 648 LLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 789 HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH 848
++L + A+ + G TPL +AC GN + + LL+ G N + KT +G+TP+H
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 849 AAVDTGNVDSLKLLMYHRIPAHGNSFN 875
A G+ + +L+ H + + N
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 90.1 bits (222), Expect = 2e-17
Identities = 70/254 (27%), Positives = 113/254 (44%), Gaps = 30/254 (11%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L +A +G V + S+LL E G + + + G + L+ AAK G D +LLL A +
Sbjct: 532 TPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+A KNG TPL AA + + LL+ A+ + A G TPL++A K + LL
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNS--------FNEEESESSV 883
G ++ T G TP+H A G+ D + LL+ H ++ +E + +V
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 884 FDL------DGGEESPEGISKPVVPADL---------------INHANREGWTAAHIAAS 922
D+ D + G + +V +N + G+T H AA
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Query: 923 KGFKNCLEILCRHG 936
+G + + +L +HG
Sbjct: 771 QGHTHIINVLLQHG 784
Score = 87.4 bits (215), Expect = 1e-16
Identities = 75/275 (27%), Positives = 117/275 (42%), Gaps = 40/275 (14%)
Query: 696 TPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
T LL G R T L A+ +GN ++ +LL+ G I+ DG + L+ AA+
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAAR 308
Query: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE------------------- 794
+GH V LLL A + A KNG +PL AA H ECV+
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Query: 795 --------------LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT 840
LL+ AN N A G TPL++ACK + ++LL++ G + T
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 841 TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV 900
G TP+H A G+++ + LL+ + + E + + E + +
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE----TALHMAARAGQVEVVRCLL 484
Query: 901 VPADLINHANREGWTAAHIAASKGFKNCLEILCRH 935
L++ RE T HIA+ G +++L +H
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 86.3 bits (212), Expect = 2e-16
Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 4/200 (2%)
Query: 737 INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL 796
+N + E G + L+ AA G+ + LLL+ A V+ +NG TPL A+ +G+ V+LL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 797 ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV 856
+ I+ G TPL+ A ++G+ + ++LLLE G +T +G +P+H A +V
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 857 DSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTA 916
+ +K L+ H+ P + + + + + K P N G+T
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTP 401
Query: 917 AHIAASKGFKNCLEILCRHG 936
HIA K +E+L ++G
Sbjct: 402 LHIACKKNRIKVMELLVKYG 421
Score = 81.6 bits (200), Expect = 6e-15
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 38/194 (19%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-- 769
T L AA + ++ ++ LL E G + + + EDG + L A + GH V +LL + +
Sbjct: 132 TPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 770 -----------------------------------VNAADKNGFTPLCAAAAQGHFECVE 794
VN ++GFTPL AA G+
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 795 LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
LL++ A ++ A G TPL++A K GN +KLLL+ G KT DG TP+H A +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 855 NVDSLKLLMYHRIP 868
+ ++LL+ P
Sbjct: 311 HDQVVELLLERGAP 324
Score = 73.6 bits (179), Expect = 2e-12
Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 4/154 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +G+ ++++LL ++G +I+ S + G ++L+ AA+ + +L A +
Sbjct: 664 TPLHLASQEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A K G+TPL A G+ + V L+ AN+N G TPL+ A + G+ I +LL+
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL 862
G + T +G T + A G VD+LK++
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 816
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + + ++ +L+ + G I E G + ++ AA GH + V LLL A +
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ G T L AA G E V L+ A ++ A QTPL++A + G E ++LLL+
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
+ TT+G+TP+H + G VD +L+
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 110 bits (276), Expect = 9e-24
Identities = 73/227 (32%), Positives = 119/227 (52%), Gaps = 13/227 (5%)
Query: 716 QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK 775
+AA GN+ + L + G+DIN ++G +AL+ AAK GH V+ LL + V++A K
Sbjct: 37 RAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 776 NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN 835
G T L A+ G E V++L+ ANIN + G TPLY+A + + + +K LLE G N
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 836 RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPAHGNSFNEEESESSVFDLDGG 889
+S T DG+TP+ A+ G+ ++ +L+ + R+PA + +++++S+ L
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 890 EESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ V ++N G+T HIAA G N +L G
Sbjct: 216 HNA------DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Score = 94.7 bits (234), Expect = 6e-19
Identities = 70/226 (30%), Positives = 109/226 (48%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T + AA G++ ++ +LL + G + + G +AL+ AA+ G + VR LL A V+
Sbjct: 433 TPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + TPL A+ G E V+LL+ + A+ + A G TPL+++ + G + +LLE
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
AG S+ T G+TP+H A G++D KLL+ R A N D +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 892 SPEGISKPVVPADLINHAN-REGWTAAHIAASKGFKNCLEILCRHG 936
+ + K P HA + G+T HIAA K L +G
Sbjct: 612 ALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Score = 94.0 bits (232), Expect = 1e-18
Identities = 67/225 (29%), Positives = 110/225 (48%), Gaps = 5/225 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA GNV + ++LLN G ++++ +G + L+ A+K G+T+ V+LLL Q++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A ++G TPL AA GH + VELL+ A + G +PL++A + + EC+K LL+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
T D T +H A G+ KLL+ R + + N + + +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN----GFTPLHIACKKN 409
Query: 892 SPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ + V I G T H+AA G N + +L ++G
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Score = 94.0 bits (232), Expect = 1e-18
Identities = 63/207 (30%), Positives = 101/207 (48%), Gaps = 4/207 (1%)
Query: 672 SASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSM 728
+A S L V A + + LL+ G +P A T L AA + + + S
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 729 LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG 788
LLN G + N + G + L+ A++ GHTD V LLL A ++ + K+G T L AA +
Sbjct: 648 LLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 789 HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH 848
++L + A+ + G TPL +AC GN + + LL+ G N + KT +G+TP+H
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 849 AAVDTGNVDSLKLLMYHRIPAHGNSFN 875
A G+ + +L+ H + + N
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 90.1 bits (222), Expect = 2e-17
Identities = 70/254 (27%), Positives = 113/254 (44%), Gaps = 30/254 (11%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L +A +G V + S+LL E G + + + G + L+ AAK G D +LLL A +
Sbjct: 532 TPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+A KNG TPL AA + + LL+ A+ + A G TPL++A K + LL
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNS--------FNEEESESSV 883
G ++ T G TP+H A G+ D + LL+ H ++ +E + +V
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 884 FDL------DGGEESPEGISKPVVPADL---------------INHANREGWTAAHIAAS 922
D+ D + G + +V +N + G+T H AA
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Query: 923 KGFKNCLEILCRHG 936
+G + + +L +HG
Sbjct: 771 QGHTHIINVLLQHG 784
Score = 87.4 bits (215), Expect = 1e-16
Identities = 75/275 (27%), Positives = 117/275 (42%), Gaps = 40/275 (14%)
Query: 696 TPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
T LL G R T L A+ +GN ++ +LL+ G I+ DG + L+ AA+
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAAR 308
Query: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE------------------- 794
+GH V LLL A + A KNG +PL AA H ECV+
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Query: 795 --------------LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT 840
LL+ AN N A G TPL++ACK + ++LL++ G + T
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 841 TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPV 900
G TP+H A G+++ + LL+ + + E + + E + +
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE----TALHMAARAGQVEVVRCLL 484
Query: 901 VPADLINHANREGWTAAHIAASKGFKNCLEILCRH 935
L++ RE T HIA+ G +++L +H
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 86.3 bits (212), Expect = 2e-16
Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 4/200 (2%)
Query: 737 INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL 796
+N + E G + L+ AA G+ + LLL+ A V+ +NG TPL A+ +G+ V+LL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 797 ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV 856
+ I+ G TPL+ A ++G+ + ++LLLE G +T +G +P+H A +V
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 857 DSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTA 916
+ +K L+ H+ P + + + + + K P N G+T
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTP 401
Query: 917 AHIAASKGFKNCLEILCRHG 936
HIA K +E+L ++G
Sbjct: 402 LHIACKKNRIKVMELLVKYG 421
Score = 81.6 bits (200), Expect = 6e-15
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 38/194 (19%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-- 769
T L AA + ++ ++ LL E G + + + EDG + L A + GH V +LL + +
Sbjct: 132 TPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 770 -----------------------------------VNAADKNGFTPLCAAAAQGHFECVE 794
VN ++GFTPL AA G+
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 795 LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
LL++ A ++ A G TPL++A K GN +KLLL+ G KT DG TP+H A +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 855 NVDSLKLLMYHRIP 868
+ ++LL+ P
Sbjct: 311 HDQVVELLLERGAP 324
Score = 73.6 bits (179), Expect = 2e-12
Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 4/154 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +G+ ++++LL ++G +I+ S + G ++L+ AA+ + +L A +
Sbjct: 664 TPLHLASQEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A K G+TPL A G+ + V L+ AN+N G TPL+ A + G+ I +LL+
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL 862
G + T +G T + A G VD+LK++
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 816
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + + ++ +L+ + G I E G + ++ AA GH + V LLL A +
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ G T L AA G E V L+ A ++ A QTPL++A + G E ++LLL+
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
+ TT+G+TP+H + G VD +L+
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Score = 43.9 bits (102), Expect = 0.001
Identities = 90/401 (22%), Positives = 142/401 (35%), Gaps = 61/401 (15%)
Query: 175 VKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTN-ELEEELSAEKRRSTEMEAQMEKQ--- 230
V+ + G V EE + D ++EE ++K E+ E E R E++ ++EK
Sbjct: 1578 VQSSRSERGLVEEEWVIVSD--EEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTG 1635
Query: 231 LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS--------------- 275
L + T+ L +E+ T DK K E L G S
Sbjct: 1636 LVNYLTDDLNTCVPLPKEQLQTVQ-----DKAGKKCEALAVGRSSEKEGKDIPPDETQST 1690
Query: 276 ----KPSLSLP----RKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMP 327
KPSL + RK K+++ G + + ++ + + P +P
Sbjct: 1691 QKQHKPSLGIKKPVRRKLKEKQKQK-EEGLQASAEKAELKKGSSEESLGEDPGLAPEPLP 1749
Query: 328 VKPSTGSPLVSANAKGSVCTSATMARPGI-DRQASYGDLIGASVPAFPPPSANKIEENGP 386
+T SPL+ GS+ + + D Q L P K +E+ P
Sbjct: 1750 TVKAT-SPLIEETPIGSIKDKVKALQKRVEDEQKGRSKL----------PIRVKGKEDVP 1798
Query: 387 S-TGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPCANTSLHPGLNPRI 445
T P P +S P L S P + +P HS S A T HP ++P
Sbjct: 1799 KKTTHRPHPAAS-PSLKSERHAPGSPSP--------KTERHSTLSSSAKTERHPPVSPSS 1849
Query: 446 QAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAG 505
+ + + +++ + S + SP S + ++ SP
Sbjct: 1850 KTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGK 1909
Query: 506 APSRPGVPPTGDVGTHPPV--GRTS--LKTHGVARVDRGNP 542
RP V P+G HPPV GRT L R D+ P
Sbjct: 1910 TDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQP 1950
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 107 bits (266), Expect = 1e-22
Identities = 73/239 (30%), Positives = 127/239 (53%), Gaps = 26/239 (10%)
Query: 732 EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE 791
+ G+DIN ++G +AL+ A+K GH + V LL EA V+AA K G T L A+ G E
Sbjct: 62 KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121
Query: 792 CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV 851
V++L++ AN+N + G TPLY+A + + E +K LL+ G ++S+ T DG+TP+ A+
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 852 DTGNVDSLKLLMYH------RIPAHGNSFNEEESESSVF----DLDGGEESPEGISKPVV 901
G+ + LL+ + R+PA + +++++++ D + ES G + +
Sbjct: 182 QQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHI 241
Query: 902 PAD---------LINHANREGWTA------AHIAASKGFKNCLEILCRHGG-LEPERRD 944
A L+N A +TA H+A+ +G N +++L G ++ + RD
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
Score = 95.9 bits (237), Expect = 3e-19
Identities = 56/169 (33%), Positives = 90/169 (53%), Gaps = 4/169 (2%)
Query: 698 LLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN 754
LL+ G +P A T L AA + + + + LL E G D N G ++++ AA+
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANAVTRQGIASVHLAAQE 674
Query: 755 GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPL 814
GH D V LLL A VN ++K+G TPL AA + E+L++ A+++ G TPL
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Query: 815 YLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
++ C GN + + LL+ + KT +G+TP+H A G+ + +L+
Sbjct: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Score = 94.4 bits (233), Expect = 8e-19
Identities = 74/287 (25%), Positives = 123/287 (42%), Gaps = 63/287 (21%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GN ++ +LL + G I+ DG + L+ A++GH V +LL A +
Sbjct: 270 TPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYD------------------------------- 800
+ KNG +PL A H CV+LL+ ++
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 801 --ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDS 858
AN N A G TPL++ACK + ++LLL+ G + T G TP+H A G+V+
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 859 LKLLMYHRIPAHGNSFNEE----------ESESSVFDLDGG---------EESPEGISKP 899
+ LM+H + + E ++E + + G +++P IS
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 900 VVPADLI----------NHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ AD++ N A G+T H++A +G ++ L HG
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555
Score = 92.8 bits (229), Expect = 2e-18
Identities = 81/304 (26%), Positives = 130/304 (42%), Gaps = 18/304 (5%)
Query: 645 GLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSL----------LVTASGWSPS 694
G + A ++S L AF +N VS GAS + + SG +
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVS-QLMHHGASPNTTNVRGETALHMAARSGQAEV 481
Query: 695 LTPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAA 752
+ L+ G + T L +A G ++ LL ++G N + G++ L+ +A
Sbjct: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL-QQGASPNAATTSGYTPLHLSA 540
Query: 753 KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQT 812
+ GH D LL A ++ K GFTPL AA G E LL+ A+ + A G T
Sbjct: 541 REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT 600
Query: 813 PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGN 872
PL++A N++ LLL+ G + +G+TP+H A +D L+ + A N
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY--GADAN 658
Query: 873 SFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEIL 932
+ + S L E + +S + +N +N+ G T H+AA + N E+L
Sbjct: 659 AVTRQGIAS--VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Query: 933 CRHG 936
G
Sbjct: 717 VNQG 720
Score = 85.5 bits (210), Expect = 4e-16
Identities = 63/239 (26%), Positives = 110/239 (46%), Gaps = 13/239 (5%)
Query: 649 PACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSP----------SLTPL 698
P + +S P ++ V+A GAS S+ T G++P + L
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI-TTKKGFTPLHVAAKYGKLEVANL 583
Query: 699 LMSGGPAP-LAGRPTLLQ-QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGH 756
L+ +P AG+ L AA + +++LL ++G + + ++G++ L+ AAK
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 757 TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL 816
D LL A NA + G + AA +GH + V LL+ +AN+N + G TPL+L
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL 703
Query: 817 ACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
A + ++L+ G + +T G+TP+H GN+ + L+ H + + N
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
Score = 85.1 bits (209), Expect = 5e-16
Identities = 63/233 (27%), Positives = 107/233 (45%), Gaps = 21/233 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA GN+ + ++LLN ++++ + + L+ A+K G+ + V+LLL A+++
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A ++G TPL A GH + VE+L+ A I G +PL++A + + C++LLL+
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D T +H A G+ K+L+ + + + N +++ V
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+L G S I G T H+AA G N + L HG
Sbjct: 416 MEL----LLKHGAS--------IQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Score = 83.6 bits (205), Expect = 1e-15
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 17/268 (6%)
Query: 679 GASDSLLVTASGWSP----------SLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSM 728
GAS SL T G++P + LL+ P L AA+ + T +
Sbjct: 163 GASQSL-ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL--HIAARKDDTKAAA 219
Query: 729 LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG 788
LL + + + + G + L+ AA G+ + LLL+ A V+ +N TPL A+ +G
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279
Query: 789 HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH 848
+ V+LL+ A I+ G TPL+ ++G+++ +++LL+ KT +G +P+H
Sbjct: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339
Query: 849 AAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINH 908
A +++ ++LL+ H +P + + + + + + K P N
Sbjct: 340 MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP----NA 395
Query: 909 ANREGWTAAHIAASKGFKNCLEILCRHG 936
G+T HIA K +E+L +HG
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHG 423
Score = 82.0 bits (201), Expect = 4e-15
Identities = 69/267 (25%), Positives = 118/267 (44%), Gaps = 12/267 (4%)
Query: 669 NPVSASSCRPGASDSL-LVTASGWSPSLTPLLMSGGPAPLAGRP--TLLQQAAAQGNVTL 725
N V + C ++L L + G ++ LL A + T L A+ G +
Sbjct: 63 NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEV 122
Query: 726 LSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAA 785
+ +L+ G ++N ++G + LY AA+ H + V+ LL A + A ++GFTPL A
Sbjct: 123 VKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 786 AQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT 845
QGH + V LL+ D L++A + + + LLL+ N V++ G+T
Sbjct: 182 QQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT 237
Query: 846 PVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADL 905
P+H A GN++ LL+ +R A + + + V G + +
Sbjct: 238 PLHIAAHYGNINVATLLL-NRAAAVDFTARNDITPLHVASKRGNANM---VKLLLDRGAK 293
Query: 906 INHANREGWTAAHIAASKGFKNCLEIL 932
I+ R+G T H A G + +E+L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEML 320
Score = 80.5 bits (197), Expect = 1e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 7/173 (4%)
Query: 698 LLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL +G LA T L A QG+ ++S+LL + + AL+ AA+
Sbjct: 159 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG-----KVRLPALHIAARKD 213
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
T LLL + + K+GFTPL AA G+ LL++ A ++ A TPL+
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
+A K GN +KLLL+ G KT DG TP+H +G+ +++L+ P
Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Score = 76.3 bits (186), Expect = 2e-13
Identities = 64/254 (25%), Positives = 107/254 (42%), Gaps = 28/254 (11%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ + +LL+++ + N +G + L+ A K + LLL A +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ 427
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A ++G TP+ AA GH V L+ + A+ N G+T L++A ++G E ++ L++
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH-----------RIPAHGNSFNEEESE 880
G K D TP+H + G D ++ L+ P H S E +
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH-LSAREGHED 546
Query: 881 SSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEP 940
+ F LD G ++ ++G+T H+AA G +L + P
Sbjct: 547 VAAFLLDHGAS--------------LSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-SP 591
Query: 941 ERRDKCNRTVHDVA 954
+ K T VA
Sbjct: 592 DAAGKSGLTPLHVA 605
Score = 75.1 bits (183), Expect = 5e-13
Identities = 60/215 (27%), Positives = 102/215 (47%), Gaps = 14/215 (6%)
Query: 696 TPLLMSGGPAPLAGRPTL--LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
T LL G A R + + AA +G+V ++S+LL ++N S + G + L+ AA+
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA-NVNLSNKSGLTPLHLAAQ 706
Query: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP 813
+ +L++ A V+A K G+TPL G+ + V L+ + A +N G TP
Sbjct: 707 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766
Query: 814 LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL----MYHR 866
L+ A + G+ I +LL+ + + T +G T + A G VD+LK++ M
Sbjct: 767 LHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTT 826
Query: 867 IPAHGNSFNEEESESSVFDLDGGE----ESPEGIS 897
+ N E+ + V D+ E +PE +S
Sbjct: 827 TVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLS 861
Score = 42.7 bits (99), Expect = 0.003
Identities = 51/198 (25%), Positives = 74/198 (37%), Gaps = 34/198 (17%)
Query: 784 AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG 843
AA GH E I +IN G L+LA K G+ E + LL+ N T G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 844 WTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN----------EEESESSVFDLDGGEESP 893
T +H A G + +K+L+ + + S N E E F LD G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ- 166
Query: 894 EGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDV 953
+ A +G+T +A +G + +L LE + + K +
Sbjct: 167 -------------SLATEDGFTPLAVALQQGHDQVVSLL-----LENDTKGKVRLPALHI 208
Query: 954 AT--DDCKH---LLENLN 966
A DD K LL+N N
Sbjct: 209 AARKDDTKAAALLLQNDN 226
>gi|239747580 PREDICTED: similar to NAV1 protein [Homo sapiens]
Length = 559
Score = 106 bits (264), Expect = 2e-22
Identities = 88/332 (26%), Positives = 156/332 (46%), Gaps = 41/332 (12%)
Query: 1043 SNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTYA 1102
S +GLS SI ++ +V + + P + +I+V L G +E C+ S+ +
Sbjct: 159 STLGLSTESIHGYSISHVKRVLDAEPPEMP---PCRRGVNNISVSLKGLKEKCVDSLVFE 215
Query: 1103 SMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEV 1162
++IP MMQ+Y+ L+ ++ ++ GP G+ + Y+ ++LA L R S V +
Sbjct: 216 TLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVER------SGREVTEGI 269
Query: 1163 DAGFSKEQL----LDLFISS-ACLIPVKQSPSKKKIIIILENL-EKSSLSELLRDFLAPL 1216
+ F+ Q L L++S+ A I + ++I+L++L E S+SEL+
Sbjct: 270 VSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELV------- 322
Query: 1217 ENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEP 1276
NG C Y H+ +++GT + + + FR + + EP
Sbjct: 323 --------------NGALTCKY-HKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEP 367
Query: 1277 MQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKY 1336
G L R+LRRK+V + + + +++DW +W L++ L + T + L+GP +
Sbjct: 368 ANGFLVRYLRRKLVES-DSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCF 426
Query: 1337 FLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQE 1368
FLSCP+ + W LWN I P +QE
Sbjct: 427 FLSCPI---GIEDFRTWFIDLWNNSIIPYLQE 455
>gi|27262622 neuron navigator 1 [Homo sapiens]
Length = 1874
Score = 106 bits (264), Expect = 2e-22
Identities = 88/332 (26%), Positives = 156/332 (46%), Gaps = 41/332 (12%)
Query: 1043 SNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTYA 1102
S +GLS SI ++ +V + + P + +I+V L G +E C+ S+ +
Sbjct: 1474 STLGLSTESIHGYSISHVKRVLDAEPPEMP---PCRRGVNNISVSLKGLKEKCVDSLVFE 1530
Query: 1103 SMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEV 1162
++IP MMQ+Y+ L+ ++ ++ GP G+ + Y+ ++LA L R S V +
Sbjct: 1531 TLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVER------SGREVTEGI 1584
Query: 1163 DAGFSKEQL----LDLFISS-ACLIPVKQSPSKKKIIIILENL-EKSSLSELLRDFLAPL 1216
+ F+ Q L L++S+ A I + ++I+L++L E S+SEL+
Sbjct: 1585 VSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELV------- 1637
Query: 1217 ENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEP 1276
NG C Y H+ +++GT + + + FR + + EP
Sbjct: 1638 --------------NGALTCKY-HKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEP 1682
Query: 1277 MQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKY 1336
G L R+LRRK+V + + + +++DW +W L++ L + T + L+GP +
Sbjct: 1683 ANGFLVRYLRRKLVES-DSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCF 1741
Query: 1337 FLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQE 1368
FLSCP+ + W LWN I P +QE
Sbjct: 1742 FLSCPI---GIEDFRTWFIDLWNNSIIPYLQE 1770
Score = 33.9 bits (76), Expect = 1.4
Identities = 48/219 (21%), Positives = 88/219 (40%), Gaps = 36/219 (16%)
Query: 188 EAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNR 247
+++++ + +LE ++K L +LSA + + A E+ L + L
Sbjct: 1079 QSEQIRKLRRELESSQEKVATLTSQLSA----NANLVAAFEQSLVNMTSRLRHLAETAEE 1134
Query: 248 EEAHTTDLKEEIDKMRK-------MIEQLKRGSDSKPS-LSLPRKTKDRRLVSISVGTEG 299
++ DL+E ID ++K +I+ S++ P L + R+ + S++ T
Sbjct: 1135 KDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSH 1194
Query: 300 TVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQ 359
+ S +++AD KK S L S+ K A + G
Sbjct: 1195 SSIGS--------SKDADAKKK---------KKKSWLRSSFNK------AFSIKKGPKSA 1231
Query: 360 ASYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSST 398
+SY D+ + P PS+ K++ T S P SST
Sbjct: 1232 SSYSDIEEIATPDSSAPSSPKLQHGSTETAS-PSIKSST 1269
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 105 bits (261), Expect = 5e-22
Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ ++ +LL E + N + GH+ L+ AA+ GH + V LL EA
Sbjct: 505 TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K GFTPL AA G ELL+ DA+ N A G TPL++A + N + +KLLL
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGE 890
G + +G+TP+H A V+ + L+ +G S N E + + L E
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQE 678
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E ++ + N N+ G T H+ A +G ++L +HG
Sbjct: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 724
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/237 (32%), Positives = 118/237 (49%), Gaps = 25/237 (10%)
Query: 708 AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
A T +AA GN+ L L N G+DIN ++G + L+ A+K GH V LL
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
E + K G T L AA G E V L++Y AN+N + G TPLY+A + + E +
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPA-HGNSFNEEES 879
K LLE G N++V T DG+TP+ A+ G+ + + L+ + R+PA H + N++
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
Query: 880 ESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
++V L + +P+ +SK G+T HIAA N ++L G
Sbjct: 221 TAAV--LLQNDPNPDVLSK-------------TGFTPLHIAAHYENLNVAQLLLNRG 262
Score = 94.4 bits (233), Expect = 8e-19
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GNV ++ +LL + G I +D + L+ AA+NGH +LL A +
Sbjct: 274 TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A KNG +P+ AA H +CV LL+ YDA I+ TPL++A G+ K+LL+
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + + +G+TP+H A +V ++LL+
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLL 424
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+V + +LL + G I ++G S ++ AA+ H DCVRLLL +A+++
Sbjct: 307 TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ TPL AA GH ++L+ A N A G TPL++ACK + ++LLL+
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + T G TP+H A G++ +K L+
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 698 LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL GG +P T L AA Q V + LL G N G + L+ AA+ G
Sbjct: 621 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG 679
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H + V LLLS +A N +K+G TPL A +GH ++LI + ++ G TPL+
Sbjct: 680 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 739
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
+A GN + +K LL+ + + KT G++P+H A G+ D + LL+ +G S N
Sbjct: 740 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-----KNGASPN 794
Query: 876 EEESESS 882
E S+ +
Sbjct: 795 EVSSDGT 801
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 25/265 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N+ + +LLN G +N++ ++G + L+ A++ G+ VRLLL AQ+
Sbjct: 241 TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K+ TPL AA GH E+L+ + A I G +P+++A + + +C++LLL+
Sbjct: 300 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 359
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D TP+H A G+ K+L+ + + N +++ V
Sbjct: 360 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERR 943
+L + K D + + G T H+A+ G ++ L + G
Sbjct: 420 MEL---------LLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Query: 944 DKCNRTVHDVA----TDDCKHLLEN 964
K +H A T+ K+LL+N
Sbjct: 468 VKVETPLHMAARAGHTEVAKYLLQN 492
Score = 84.7 bits (208), Expect = 7e-16
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 21/234 (8%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + +V ++ +LL + G I+ E G + L+ A+ GH V+ LL A N
Sbjct: 406 TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
++ TPL AA GH E + L+ A +N A QTPL+ A + G+ +KLLLE
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG--- 888
N ++ TT G TP+H A G+V+++ L+ E+E+ + G
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALL------------EKEASQACMTKKGFTP 572
Query: 889 ----GEESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEILCRHGG 937
+ +++ ++ D N A + G T H+A + +++L GG
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Score = 82.0 bits (201), Expect = 4e-15
Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 30/193 (15%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS------------------------- 746
T L AA + ++ ++ LL E G + N + EDG +
Sbjct: 146 TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 204
Query: 747 ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802
AL+ AA+N T +LL + + K GFTPL AA + +LL++ A+
Sbjct: 205 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 264
Query: 803 INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
+N G TPL++A + GN ++LLL+ G KT D TP+H A G+V ++L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Query: 863 MYHRIPAHGNSFN 875
+ H P + N
Sbjct: 325 LDHGAPIQAKTKN 337
Score = 78.6 bits (192), Expect = 5e-14
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G V + +LL E N + ++G + L+ A + + D V+LLL +
Sbjct: 571 TPLHVAAKYGKVRVAELLL-ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ NG+TPL AA Q E L+ Y + N + G TPL+LA + G+ E + LLL
Sbjct: 630 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
N ++ G TP+H G+V +L+ H +
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 26/230 (11%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
AA+ + T + +L + + + + G + L+ AA + + +LLL+ A VN +NG
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL A+ +G+ V LL+ A I TPL+ A +NG+ ++LL+ G
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMY-----------HRIPAHGNSFNEEESESSVFDL 886
KT +G +P+H A ++D ++LL+ H P H + + V L
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-L 391
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
D G +KP N G+T HIA K +E+L + G
Sbjct: 392 DKG-------AKP-------NSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Score = 74.3 bits (181), Expect = 9e-13
Identities = 42/151 (27%), Positives = 83/151 (54%), Gaps = 1/151 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA +G+ ++++LL+++ + N + G + L+ A+ GH +L+ V+
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + G+TPL A+ G+ + V+ L+ + A++N G +PL+ A + G+ + + LLL+
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
G + + ++DG TP+ A G + +L
Sbjct: 789 NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 105 bits (261), Expect = 5e-22
Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ ++ +LL E + N + GH+ L+ AA+ GH + V LL EA
Sbjct: 472 TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K GFTPL AA G ELL+ DA+ N A G TPL++A + N + +KLLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGE 890
G + +G+TP+H A V+ + L+ +G S N E + + L E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQE 645
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E ++ + N N+ G T H+ A +G ++L +HG
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/237 (32%), Positives = 118/237 (49%), Gaps = 25/237 (10%)
Query: 708 AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
A T +AA GN+ L L N G+DIN ++G + L+ A+K GH V LL
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
E + K G T L AA G E V L++Y AN+N + G TPLY+A + + E +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPA-HGNSFNEEES 879
K LLE G N++V T DG+TP+ A+ G+ + + L+ + R+PA H + N++
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 880 ESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
++V L + +P+ +SK G+T HIAA N ++L G
Sbjct: 188 TAAV--LLQNDPNPDVLSK-------------TGFTPLHIAAHYENLNVAQLLLNRG 229
Score = 94.4 bits (233), Expect = 8e-19
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GNV ++ +LL + G I +D + L+ AA+NGH +LL A +
Sbjct: 241 TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A KNG +P+ AA H +CV LL+ YDA I+ TPL++A G+ K+LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + + +G+TP+H A +V ++LL+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+V + +LL + G I ++G S ++ AA+ H DCVRLLL +A+++
Sbjct: 274 TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ TPL AA GH ++L+ A N A G TPL++ACK + ++LLL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + T G TP+H A G++ +K L+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 698 LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL GG +P T L AA Q V + LL G N G + L+ AA+ G
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG 646
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H + V LLLS +A N +K+G TPL A +GH ++LI + ++ G TPL+
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
+A GN + +K LL+ + + KT G++P+H A G+ D + LL+ +G S N
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-----KNGASPN 761
Query: 876 EEESESS 882
E S+ +
Sbjct: 762 EVSSDGT 768
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 25/265 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N+ + +LLN G +N++ ++G + L+ A++ G+ VRLLL AQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K+ TPL AA GH E+L+ + A I G +P+++A + + +C++LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D TP+H A G+ K+L+ + + N +++ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERR 943
+L + K D + + G T H+A+ G ++ L + G
Sbjct: 387 MEL---------LLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 944 DKCNRTVHDVA----TDDCKHLLEN 964
K +H A T+ K+LL+N
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQN 459
Score = 84.7 bits (208), Expect = 7e-16
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 21/234 (8%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + +V ++ +LL + G I+ E G + L+ A+ GH V+ LL A N
Sbjct: 373 TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
++ TPL AA GH E + L+ A +N A QTPL+ A + G+ +KLLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG--- 888
N ++ TT G TP+H A G+V+++ L+ E+E+ + G
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL------------EKEASQACMTKKGFTP 539
Query: 889 ----GEESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEILCRHGG 937
+ +++ ++ D N A + G T H+A + +++L GG
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Score = 82.0 bits (201), Expect = 4e-15
Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 30/193 (15%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS------------------------- 746
T L AA + ++ ++ LL E G + N + EDG +
Sbjct: 113 TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 747 ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802
AL+ AA+N T +LL + + K GFTPL AA + +LL++ A+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 803 INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
+N G TPL++A + GN ++LLL+ G KT D TP+H A G+V ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 863 MYHRIPAHGNSFN 875
+ H P + N
Sbjct: 292 LDHGAPIQAKTKN 304
Score = 78.6 bits (192), Expect = 5e-14
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G V + +LL E N + ++G + L+ A + + D V+LLL +
Sbjct: 538 TPLHVAAKYGKVRVAELLL-ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ NG+TPL AA Q E L+ Y + N + G TPL+LA + G+ E + LLL
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
N ++ G TP+H G+V +L+ H +
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 26/230 (11%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
AA+ + T + +L + + + + G + L+ AA + + +LLL+ A VN +NG
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL A+ +G+ V LL+ A I TPL+ A +NG+ ++LL+ G
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMY-----------HRIPAHGNSFNEEESESSVFDL 886
KT +G +P+H A ++D ++LL+ H P H + + V L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-L 358
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
D G +KP N G+T HIA K +E+L + G
Sbjct: 359 DKG-------AKP-------NSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 75.5 bits (184), Expect = 4e-13
Identities = 53/188 (28%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA +G+ ++++LL+++ + N + G + L+ A+ GH +L+ V+
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + G+TPL A+ G+ + V+ L+ + A++N G +PL+ A + G+ + + LLL+
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNV---DSLKLLMYHR-----IPAHGNSFNEEESESSV 883
G + + ++DG TP+ A G + D LK++ H SF E E
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 884 FDLDGGEE 891
D GEE
Sbjct: 816 VSEDEGEE 823
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 105 bits (261), Expect = 5e-22
Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ ++ +LL E + N + GH+ L+ AA+ GH + V LL EA
Sbjct: 472 TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K GFTPL AA G ELL+ DA+ N A G TPL++A + N + +KLLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGE 890
G + +G+TP+H A V+ + L+ +G S N E + + L E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQE 645
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E ++ + N N+ G T H+ A +G ++L +HG
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/237 (32%), Positives = 118/237 (49%), Gaps = 25/237 (10%)
Query: 708 AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
A T +AA GN+ L L N G+DIN ++G + L+ A+K GH V LL
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
E + K G T L AA G E V L++Y AN+N + G TPLY+A + + E +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPA-HGNSFNEEES 879
K LLE G N++V T DG+TP+ A+ G+ + + L+ + R+PA H + N++
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 880 ESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
++V L + +P+ +SK G+T HIAA N ++L G
Sbjct: 188 TAAV--LLQNDPNPDVLSK-------------TGFTPLHIAAHYENLNVAQLLLNRG 229
Score = 94.4 bits (233), Expect = 8e-19
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GNV ++ +LL + G I +D + L+ AA+NGH +LL A +
Sbjct: 241 TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A KNG +P+ AA H +CV LL+ YDA I+ TPL++A G+ K+LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + + +G+TP+H A +V ++LL+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+V + +LL + G I ++G S ++ AA+ H DCVRLLL +A+++
Sbjct: 274 TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ TPL AA GH ++L+ A N A G TPL++ACK + ++LLL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + T G TP+H A G++ +K L+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 698 LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL GG +P T L AA Q V + LL G N G + L+ AA+ G
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG 646
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H + V LLLS +A N +K+G TPL A +GH ++LI + ++ G TPL+
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
+A GN + +K LL+ + + KT G++P+H A G+ D + LL+ +G S N
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-----KNGASPN 761
Query: 876 EEESESS 882
E S+ +
Sbjct: 762 EVSSDGT 768
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 25/265 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N+ + +LLN G +N++ ++G + L+ A++ G+ VRLLL AQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K+ TPL AA GH E+L+ + A I G +P+++A + + +C++LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D TP+H A G+ K+L+ + + N +++ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERR 943
+L + K D + + G T H+A+ G ++ L + G
Sbjct: 387 MEL---------LLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 944 DKCNRTVHDVA----TDDCKHLLEN 964
K +H A T+ K+LL+N
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQN 459
Score = 84.7 bits (208), Expect = 7e-16
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 21/234 (8%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + +V ++ +LL + G I+ E G + L+ A+ GH V+ LL A N
Sbjct: 373 TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
++ TPL AA GH E + L+ A +N A QTPL+ A + G+ +KLLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG--- 888
N ++ TT G TP+H A G+V+++ L+ E+E+ + G
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL------------EKEASQACMTKKGFTP 539
Query: 889 ----GEESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEILCRHGG 937
+ +++ ++ D N A + G T H+A + +++L GG
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Score = 82.0 bits (201), Expect = 4e-15
Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 30/193 (15%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS------------------------- 746
T L AA + ++ ++ LL E G + N + EDG +
Sbjct: 113 TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 747 ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802
AL+ AA+N T +LL + + K GFTPL AA + +LL++ A+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 803 INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
+N G TPL++A + GN ++LLL+ G KT D TP+H A G+V ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 863 MYHRIPAHGNSFN 875
+ H P + N
Sbjct: 292 LDHGAPIQAKTKN 304
Score = 78.6 bits (192), Expect = 5e-14
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G V + +LL E N + ++G + L+ A + + D V+LLL +
Sbjct: 538 TPLHVAAKYGKVRVAELLL-ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ NG+TPL AA Q E L+ Y + N + G TPL+LA + G+ E + LLL
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
N ++ G TP+H G+V +L+ H +
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 26/230 (11%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
AA+ + T + +L + + + + G + L+ AA + + +LLL+ A VN +NG
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL A+ +G+ V LL+ A I TPL+ A +NG+ ++LL+ G
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMY-----------HRIPAHGNSFNEEESESSVFDL 886
KT +G +P+H A ++D ++LL+ H P H + + V L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-L 358
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
D G +KP N G+T HIA K +E+L + G
Sbjct: 359 DKG-------AKP-------NSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 75.5 bits (184), Expect = 4e-13
Identities = 53/188 (28%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA +G+ ++++LL+++ + N + G + L+ A+ GH +L+ V+
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + G+TPL A+ G+ + V+ L+ + A++N G +PL+ A + G+ + + LLL+
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNV---DSLKLLMYHR-----IPAHGNSFNEEESESSV 883
G + + ++DG TP+ A G + D LK++ H SF E E
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 884 FDLDGGEE 891
D GEE
Sbjct: 816 VSEDEGEE 823
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 105 bits (261), Expect = 5e-22
Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ ++ +LL E + N + GH+ L+ AA+ GH + V LL EA
Sbjct: 472 TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K GFTPL AA G ELL+ DA+ N A G TPL++A + N + +KLLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGE 890
G + +G+TP+H A V+ + L+ +G S N E + + L E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQE 645
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E ++ + N N+ G T H+ A +G ++L +HG
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/237 (32%), Positives = 118/237 (49%), Gaps = 25/237 (10%)
Query: 708 AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
A T +AA GN+ L L N G+DIN ++G + L+ A+K GH V LL
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
E + K G T L AA G E V L++Y AN+N + G TPLY+A + + E +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPA-HGNSFNEEES 879
K LLE G N++V T DG+TP+ A+ G+ + + L+ + R+PA H + N++
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 880 ESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
++V L + +P+ +SK G+T HIAA N ++L G
Sbjct: 188 TAAV--LLQNDPNPDVLSK-------------TGFTPLHIAAHYENLNVAQLLLNRG 229
Score = 94.4 bits (233), Expect = 8e-19
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GNV ++ +LL + G I +D + L+ AA+NGH +LL A +
Sbjct: 241 TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A KNG +P+ AA H +CV LL+ YDA I+ TPL++A G+ K+LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + + +G+TP+H A +V ++LL+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+V + +LL + G I ++G S ++ AA+ H DCVRLLL +A+++
Sbjct: 274 TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ TPL AA GH ++L+ A N A G TPL++ACK + ++LLL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + T G TP+H A G++ +K L+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 698 LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL GG +P T L AA Q V + LL G N G + L+ AA+ G
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG 646
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H + V LLLS +A N +K+G TPL A +GH ++LI + ++ G TPL+
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
+A GN + +K LL+ + + KT G++P+H A G+ D + LL+ +G S N
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-----KNGASPN 761
Query: 876 EEESESS 882
E S+ +
Sbjct: 762 EVSSDGT 768
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 25/265 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N+ + +LLN G +N++ ++G + L+ A++ G+ VRLLL AQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K+ TPL AA GH E+L+ + A I G +P+++A + + +C++LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D TP+H A G+ K+L+ + + N +++ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERR 943
+L + K D + + G T H+A+ G ++ L + G
Sbjct: 387 MEL---------LLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 944 DKCNRTVHDVA----TDDCKHLLEN 964
K +H A T+ K+LL+N
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQN 459
Score = 84.7 bits (208), Expect = 7e-16
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 21/234 (8%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + +V ++ +LL + G I+ E G + L+ A+ GH V+ LL A N
Sbjct: 373 TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
++ TPL AA GH E + L+ A +N A QTPL+ A + G+ +KLLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG--- 888
N ++ TT G TP+H A G+V+++ L+ E+E+ + G
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL------------EKEASQACMTKKGFTP 539
Query: 889 ----GEESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEILCRHGG 937
+ +++ ++ D N A + G T H+A + +++L GG
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Score = 82.0 bits (201), Expect = 4e-15
Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 30/193 (15%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS------------------------- 746
T L AA + ++ ++ LL E G + N + EDG +
Sbjct: 113 TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 747 ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802
AL+ AA+N T +LL + + K GFTPL AA + +LL++ A+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 803 INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
+N G TPL++A + GN ++LLL+ G KT D TP+H A G+V ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 863 MYHRIPAHGNSFN 875
+ H P + N
Sbjct: 292 LDHGAPIQAKTKN 304
Score = 78.6 bits (192), Expect = 5e-14
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G V + +LL E N + ++G + L+ A + + D V+LLL +
Sbjct: 538 TPLHVAAKYGKVRVAELLL-ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ NG+TPL AA Q E L+ Y + N + G TPL+LA + G+ E + LLL
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
N ++ G TP+H G+V +L+ H +
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 26/230 (11%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
AA+ + T + +L + + + + G + L+ AA + + +LLL+ A VN +NG
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL A+ +G+ V LL+ A I TPL+ A +NG+ ++LL+ G
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMY-----------HRIPAHGNSFNEEESESSVFDL 886
KT +G +P+H A ++D ++LL+ H P H + + V L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-L 358
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
D G +KP N G+T HIA K +E+L + G
Sbjct: 359 DKG-------AKP-------NSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 75.5 bits (184), Expect = 4e-13
Identities = 53/188 (28%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA +G+ ++++LL+++ + N + G + L+ A+ GH +L+ V+
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + G+TPL A+ G+ + V+ L+ + A++N G +PL+ A + G+ + + LLL+
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNV---DSLKLLMYHR-----IPAHGNSFNEEESESSV 883
G + + ++DG TP+ A G + D LK++ H SF E E
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 884 FDLDGGEE 891
D GEE
Sbjct: 816 VSEDEGEE 823
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 105 bits (261), Expect = 5e-22
Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+ ++ +LL E + N + GH+ L+ AA+ GH + V LL EA
Sbjct: 472 TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K GFTPL AA G ELL+ DA+ N A G TPL++A + N + +KLLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGE 890
G + +G+TP+H A V+ + L+ +G S N E + + L E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQE 645
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E ++ + N N+ G T H+ A +G ++L +HG
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/237 (32%), Positives = 118/237 (49%), Gaps = 25/237 (10%)
Query: 708 AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
A T +AA GN+ L L N G+DIN ++G + L+ A+K GH V LL
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
E + K G T L AA G E V L++Y AN+N + G TPLY+A + + E +
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPA-HGNSFNEEES 879
K LLE G N++V T DG+TP+ A+ G+ + + L+ + R+PA H + N++
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 880 ESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
++V L + +P+ +SK G+T HIAA N ++L G
Sbjct: 188 TAAV--LLQNDPNPDVLSK-------------TGFTPLHIAAHYENLNVAQLLLNRG 229
Score = 94.4 bits (233), Expect = 8e-19
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A+ +GNV ++ +LL + G I +D + L+ AA+NGH +LL A +
Sbjct: 241 TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A KNG +P+ AA H +CV LL+ YDA I+ TPL++A G+ K+LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + + +G+TP+H A +V ++LL+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Score = 90.9 bits (224), Expect = 9e-18
Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G+V + +LL + G I ++G S ++ AA+ H DCVRLLL +A+++
Sbjct: 274 TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ TPL AA GH ++L+ A N A G TPL++ACK + ++LLL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G + T G TP+H A G++ +K L+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 698 LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
LL GG +P T L AA Q V + LL G N G + L+ AA+ G
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG 646
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H + V LLLS +A N +K+G TPL A +GH ++LI + ++ G TPL+
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN 875
+A GN + +K LL+ + + KT G++P+H A G+ D + LL+ +G S N
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-----KNGASPN 761
Query: 876 EEESESS 882
E S+ +
Sbjct: 762 EVSSDGT 768
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/265 (26%), Positives = 119/265 (44%), Gaps = 25/265 (9%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N+ + +LLN G +N++ ++G + L+ A++ G+ VRLLL AQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
K+ TPL AA GH E+L+ + A I G +P+++A + + +C++LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE--------EESESSV 883
T D TP+H A G+ K+L+ + + N +++ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERR 943
+L + K D + + G T H+A+ G ++ L + G
Sbjct: 387 MEL---------LLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 944 DKCNRTVHDVA----TDDCKHLLEN 964
K +H A T+ K+LL+N
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQN 459
Score = 84.7 bits (208), Expect = 7e-16
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 21/234 (8%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L A + +V ++ +LL + G I+ E G + L+ A+ GH V+ LL A N
Sbjct: 373 TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
++ TPL AA GH E + L+ A +N A QTPL+ A + G+ +KLLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG--- 888
N ++ TT G TP+H A G+V+++ L+ E+E+ + G
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL------------EKEASQACMTKKGFTP 539
Query: 889 ----GEESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEILCRHGG 937
+ +++ ++ D N A + G T H+A + +++L GG
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Score = 82.0 bits (201), Expect = 4e-15
Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 30/193 (15%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS------------------------- 746
T L AA + ++ ++ LL E G + N + EDG +
Sbjct: 113 TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 747 ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN 802
AL+ AA+N T +LL + + K GFTPL AA + +LL++ A+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 803 INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
+N G TPL++A + GN ++LLL+ G KT D TP+H A G+V ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 863 MYHRIPAHGNSFN 875
+ H P + N
Sbjct: 292 LDHGAPIQAKTKN 304
Score = 78.6 bits (192), Expect = 5e-14
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA G V + +LL E N + ++G + L+ A + + D V+LLL +
Sbjct: 538 TPLHVAAKYGKVRVAELLL-ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ NG+TPL AA Q E L+ Y + N + G TPL+LA + G+ E + LLL
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI 867
N ++ G TP+H G+V +L+ H +
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 26/230 (11%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
AA+ + T + +L + + + + G + L+ AA + + +LLL+ A VN +NG
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL A+ +G+ V LL+ A I TPL+ A +NG+ ++LL+ G
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMY-----------HRIPAHGNSFNEEESESSVFDL 886
KT +G +P+H A ++D ++LL+ H P H + + V L
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-L 358
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
D G +KP N G+T HIA K +E+L + G
Sbjct: 359 DKG-------AKP-------NSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 75.5 bits (184), Expect = 4e-13
Identities = 53/188 (28%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA +G+ ++++LL+++ + N + G + L+ A+ GH +L+ V+
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + G+TPL A+ G+ + V+ L+ + A++N G +PL+ A + G+ + + LLL+
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNV---DSLKLLMYHR-----IPAHGNSFNEEESESSV 883
G + + ++DG TP+ A G + D LK++ H SF E E
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 884 FDLDGGEE 891
D GEE
Sbjct: 816 VSEDEGEE 823
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 105 bits (261), Expect = 5e-22
Identities = 67/220 (30%), Positives = 115/220 (52%), Gaps = 7/220 (3%)
Query: 718 AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG 777
A++G+ +++S+L+ + G ++++ +DG + L AA GH D V LLL A V+ D NG
Sbjct: 723 ASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781
Query: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
TPL AAA+ GH V L+ + A ++ G+T L +A GN E ++ LL+ G + +
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSV-FDLDGGEESPEGI 896
+ GWTP+H A G+ L+ + G NE +++ + F L E + +
Sbjct: 842 HRDDAGWTPLHMAAFEGH-----RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896
Query: 897 SKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
+ I+ +G A +AA +G ++ +E+L HG
Sbjct: 897 QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
Score = 94.7 bits (234), Expect = 6e-19
Identities = 79/308 (25%), Positives = 136/308 (44%), Gaps = 44/308 (14%)
Query: 684 LLVTASGWSPSLTPLLMSGGPA----PLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINY 739
LL AS S+ L+ G A GR T+L A+AQGNV ++ LL + GLD N+
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIASAQGNVEVVRTLL-DRGLDENH 842
Query: 740 SCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY 799
+ G + L+ AA GH L+ A+ N D +G P A+ +GH++CV++L+
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 800 DANINHAADGGQTPLYLACKNGNKECIKLL------------------------------ 829
+NI+ G+ L +A G+++ ++LL
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 830 ---LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDL 886
LE G N +G T +H + G+++ +++L I H + + + S
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL----IAYHADVNAADNEKRSALQS 1018
Query: 887 DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKC 946
+ + + + +++H +G TA IAA +G + +++L HG +P D+
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGA-DPNHADQF 1077
Query: 947 NRTVHDVA 954
RT VA
Sbjct: 1078 GRTAMRVA 1085
Score = 90.5 bits (223), Expect = 1e-17
Identities = 77/264 (29%), Positives = 115/264 (43%), Gaps = 45/264 (17%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L+ AA G+ ++S LL G+ ++ + D +AL +AA GH D V LL A+VN
Sbjct: 613 TALRSAAWGGHTEVVSALLYA-GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADG--------------------- 809
AD G T L AAA GH E VE L+ + A +NH DG
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
Query: 810 ----------------GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDT 853
G TPL +A G+ + + LLLE G + +G TP+ AA
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASM 791
Query: 854 GNVDSLKLLMYHRIPAHGNSFNEEESES-SVFDLDGGEESPEGISKPVVPADLINHANRE 912
G+ + L++ G + + +SE +V + + + E + + NH +
Sbjct: 792 GHASVVNTLLF-----WGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA 846
Query: 913 GWTAAHIAASKGFKNCLEILCRHG 936
GWT H+AA +G + E L G
Sbjct: 847 GWTPLHMAAFEGHRLICEALIEQG 870
Score = 87.0 bits (214), Expect = 1e-16
Identities = 70/226 (30%), Positives = 101/226 (44%), Gaps = 12/226 (5%)
Query: 730 LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGH 789
L + G +N +G + L +AA +G D V LL+S A + D +G TPL AA QGH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 790 FECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHA 849
+ V LI ANINH G T L A G+ E + LL AG D T + A
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 850 AVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADL-INH 908
A G+ D + L+ HG N+ ++E + I + ++ +NH
Sbjct: 651 AAWGGHEDIVLNLL-----QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Query: 909 ANREGWTAAHIA-----ASKGFKNCLEILCRHGGLEPERRDKCNRT 949
+ +G TA +A ASKG + + +L G E + DK T
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLIDRGA-EVDHCDKDGMT 750
Score = 85.1 bits (209), Expect = 5e-16
Identities = 52/154 (33%), Positives = 86/154 (55%), Gaps = 2/154 (1%)
Query: 709 GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA 768
GRPTL A + +T+ L E G ++ S +G +AL+ + GH + V++L++ A
Sbjct: 946 GRPTLYI-LALENQLTMAEYFL-ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
Query: 769 QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL 828
VNAAD + L +AA QGH + V+LLI + A ++H + G T L +A + G+ + +++
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063
Query: 829 LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
LLE G + + G T + A G+ +KLL
Sbjct: 1064 LLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 79.3 bits (194), Expect = 3e-14
Identities = 45/124 (36%), Positives = 72/124 (58%), Gaps = 1/124 (0%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L + QG++ ++ +L+ D+N + + SAL SAA GH V+LL+ A V+
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHA-DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
G T LC AA +GH + V++L+ + A+ NHA G+T + +A KNG+ + IKLL +
Sbjct: 1040 HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Query: 832 AGTN 835
G +
Sbjct: 1100 YGAS 1103
Score = 78.6 bits (192), Expect = 5e-14
Identities = 66/226 (29%), Positives = 99/226 (43%), Gaps = 7/226 (3%)
Query: 729 LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG 788
LL + G +N ED ++ D +R LL A VN D NG T L AA G
Sbjct: 499 LLVKAGAHVN--SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSG 556
Query: 789 HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH 848
+ V LL+S A++ G TPL LA + G+ + + L+ G N + DGWT +
Sbjct: 557 SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALR 616
Query: 849 AAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINH 908
+A G+ + + L+Y + + + + + GG E + + + +N
Sbjct: 617 SAAWGGHTEVVSALLYAGVKV--DCADADSRTALRAAAWGGHE--DIVLNLLQHGAEVNK 672
Query: 909 ANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVA 954
A+ EG TA AA G + +E L HG E D RT VA
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGA-EVNHEDVDGRTALSVA 717
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 103 bits (257), Expect = 1e-21
Identities = 58/152 (38%), Positives = 89/152 (58%), Gaps = 2/152 (1%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T + +AA +G L L+ E G +N D + L++A+ G CV+LLL+A AQV+
Sbjct: 21 TPVHEAAQRGESLQLQQLI-ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
A + +G TPLC A A G ECV+LL+SY A +N +PL+ AC +G+ EC++LL++
Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
G N TP+H A ++D +K+L+
Sbjct: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLL 170
Score = 76.6 bits (187), Expect = 2e-13
Identities = 66/213 (30%), Positives = 104/213 (48%), Gaps = 10/213 (4%)
Query: 636 VGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSL 695
VG W TP +++ A SL + I + +N V+ S P + SL G + +
Sbjct: 14 VGFWVERTP-VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASL----QGQARCV 68
Query: 696 TPLLMSGGPAPLAG--RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
LL +G T L A A G++ + +LL+ G +N S L+ A
Sbjct: 69 QLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSY-GAKVNPPLYTA-SPLHEACM 126
Query: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP 813
+G ++CVRLL+ A + A D + TPL A A+ H +CV++L++ AN+N AA +T
Sbjct: 127 SGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETA 185
Query: 814 LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP 846
L+ A K N + I++L+E G N + G P
Sbjct: 186 LHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
Score = 32.7 bits (73), Expect = 3.0
Identities = 17/53 (32%), Positives = 30/53 (56%)
Query: 811 QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
+TP++ A + G ++ L+E+G + T D TP+HAA G ++LL+
Sbjct: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL 72
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 100 bits (249), Expect = 1e-20
Identities = 70/279 (25%), Positives = 138/279 (49%), Gaps = 37/279 (13%)
Query: 34 DTLSKSELRMLLSVMEGELEARDLVIEALRARRKEV-FIQERYGRFNLNDPFLALQRDYE 92
+ LS+ +L LLS++EGEL+ARD VI L+A + ++ ++ +YG ALQRD
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
Query: 93 AGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKK-------------- 138
++ + P++ L+ V+ K+ R+ QL AE +++
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 139 -----------LEMEKLQLQAL-----------EQEHKKLAARLEEERGKNKQVVLMLVK 176
LE E +L+ L EQE +K L+EE K K LM+V
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 177 ECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDT 236
E ++L+ ++ + QK++++ +E K E + E++++T +E +++ Q ++F
Sbjct: 245 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 304
Query: 237 EREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS 275
+++ + AKL E++ L++++ + + I++L+ + S
Sbjct: 305 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRS 343
Score = 56.6 bits (135), Expect = 2e-07
Identities = 93/392 (23%), Positives = 160/392 (40%), Gaps = 54/392 (13%)
Query: 123 ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS 182
+ +S ++ + + K ++ + L E E++ L R ER K + L KE + +
Sbjct: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQ----FLSKELEHVK 681
Query: 183 GKVIEE--AQKLED-----VMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFD 235
++ + A+K E + +L+EE+ K+ L E+ A K + E A E +
Sbjct: 682 MELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT-EDLICHLQ 740
Query: 236 TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS-KPSLSLPRKTKDRRLVSIS 294
+ L+ KLN++E DL EI+ + K +E+ + S S +PSL+ R+ D ++ S
Sbjct: 741 GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN-GRRISDPQVFSKE 799
Query: 295 VGTEGT----------VTRSVACQTDLVTENADHMKKLP------LTMPVKPSTGSPL-- 336
V TE + A + E +++ + P L+ ST P+
Sbjct: 800 VQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQSTPCPVNR 859
Query: 337 -----VSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPPPSANKIEENGPSTGST 391
+ +G + +P + GDL+ + P P K+ + +T
Sbjct: 860 KLWIPWMKSKEGHLQNGKMQTKPNAN-FVQPGDLVLSHTPG--QPLHIKVTPDHVQNTAT 916
Query: 392 PDPTSSTPPLP----SNAAPPTAQTPG---IAPQNSQAPPMHSLHSPCANTSLHPGLNPR 444
+ TS T P S A P TP QN+ P+ S S +L G++P
Sbjct: 917 LEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSKTSTEDLMNLEQGMSP- 975
Query: 445 IQAARFRFQGNANDPDQNGNTTQSPPSRDVSP 476
I A F A P+ G+ T P R +SP
Sbjct: 976 ITMATF---ARAQTPESCGSLT---PERTMSP 1001
Score = 49.3 bits (116), Expect = 3e-05
Identities = 49/203 (24%), Positives = 98/203 (48%), Gaps = 23/203 (11%)
Query: 133 ESRQKKLEMEKL--QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSG-KVIEEA 189
E R++ L+ME +L +E++ + L RLE E ++K L + K K++ + +E+A
Sbjct: 374 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 433
Query: 190 -----QKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEA-QMEKQLSEFDTEREQLRA 243
Q+ + LE+E+ T +L +EL + K R E+EA + + +EF + + +
Sbjct: 434 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 493
Query: 244 KLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTR 303
K T +D+ + M E+LK+ D + S + + ++ +++ R
Sbjct: 494 K--------TLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
Query: 304 SVACQTDL------VTENADHMK 320
++ +TD+ VT+ D +K
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLK 568
Score = 49.3 bits (116), Expect = 3e-05
Identities = 41/173 (23%), Positives = 76/173 (43%), Gaps = 30/173 (17%)
Query: 112 EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV 171
E C +ERM+ + + E K+ ++ +L+A+E +K L+E+ K K +
Sbjct: 440 ECYSLKCNLEKERMTTKQLSQELESLKVRIK--ELEAIESRLEKTEFTLKEDLTKLKTLT 497
Query: 172 LMLVKECKQLSGKVIEEAQKLE--------------DVMAKLEEEKKKTNELEEELSAEK 217
+M V E K +S K+ + KL+ V KL EE K
Sbjct: 498 VMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETK------------- 544
Query: 218 RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK 270
R+ + + +E+++ ER+ L+ KL EE DL ++ ++ ++ L+
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
Score = 46.2 bits (108), Expect = 3e-04
Identities = 65/285 (22%), Positives = 126/285 (44%), Gaps = 48/285 (16%)
Query: 11 DLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVF 70
+L + D G E K E L+K R L + +LE L K +
Sbjct: 374 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL--------SKRIM 425
Query: 71 IQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQL 129
E+ L D F +++ + + EK+ + T LS LE++ K++ E + ++L
Sbjct: 426 ALEK-----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL-EAIESRL 479
Query: 130 AAAESRQKK------------LEMEKLQLQALEQEHKKLAA---RLEEERGKNKQVVLML 174
E K+ ++ K + L++ KL A +L+ E+ K V L
Sbjct: 480 EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 539
Query: 175 VKECKQ-------LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQM 227
++E K+ + K+ ++ +D+ KL+ E++K N+L ++ K R +EA
Sbjct: 540 IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEA-- 597
Query: 228 EKQLSEFDTEREQLRAKLNREEA-HTTDLKEEIDKMRKMIEQLKR 271
E++ L+ KLN++ TT L +E +K++++ ++++R
Sbjct: 598 --------IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 100 bits (249), Expect = 1e-20
Identities = 70/279 (25%), Positives = 138/279 (49%), Gaps = 37/279 (13%)
Query: 34 DTLSKSELRMLLSVMEGELEARDLVIEALRARRKEV-FIQERYGRFNLNDPFLALQRDYE 92
+ LS+ +L LLS++EGEL+ARD VI L+A + ++ ++ +YG ALQRD
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
Query: 93 AGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKK-------------- 138
++ + P++ L+ V+ K+ R+ QL AE +++
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 139 -----------LEMEKLQLQAL-----------EQEHKKLAARLEEERGKNKQVVLMLVK 176
LE E +L+ L EQE +K L+EE K K LM+V
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 177 ECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDT 236
E ++L+ ++ + QK++++ +E K E + E++++T +E +++ Q ++F
Sbjct: 245 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 304
Query: 237 EREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS 275
+++ + AKL E++ L++++ + + I++L+ + S
Sbjct: 305 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRS 343
Score = 56.6 bits (135), Expect = 2e-07
Identities = 93/392 (23%), Positives = 160/392 (40%), Gaps = 54/392 (13%)
Query: 123 ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS 182
+ +S ++ + + K ++ + L E E++ L R ER K + L KE + +
Sbjct: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQ----FLSKELEHVK 681
Query: 183 GKVIEE--AQKLED-----VMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFD 235
++ + A+K E + +L+EE+ K+ L E+ A K + E A E +
Sbjct: 682 MELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT-EDLICHLQ 740
Query: 236 TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS-KPSLSLPRKTKDRRLVSIS 294
+ L+ KLN++E DL EI+ + K +E+ + S S +PSL+ R+ D ++ S
Sbjct: 741 GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN-GRRISDPQVFSKE 799
Query: 295 VGTEGT----------VTRSVACQTDLVTENADHMKKLP------LTMPVKPSTGSPL-- 336
V TE + A + E +++ + P L+ ST P+
Sbjct: 800 VQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQSTPCPVNR 859
Query: 337 -----VSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPPPSANKIEENGPSTGST 391
+ +G + +P + GDL+ + P P K+ + +T
Sbjct: 860 KLWIPWMKSKEGHLQNGKMQTKPNAN-FVQPGDLVLSHTPG--QPLHIKVTPDHVQNTAT 916
Query: 392 PDPTSSTPPLP----SNAAPPTAQTPG---IAPQNSQAPPMHSLHSPCANTSLHPGLNPR 444
+ TS T P S A P TP QN+ P+ S S +L G++P
Sbjct: 917 LEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSKTSTEDLMNLEQGMSP- 975
Query: 445 IQAARFRFQGNANDPDQNGNTTQSPPSRDVSP 476
I A F A P+ G+ T P R +SP
Sbjct: 976 ITMATF---ARAQTPESCGSLT---PERTMSP 1001
Score = 49.3 bits (116), Expect = 3e-05
Identities = 49/203 (24%), Positives = 98/203 (48%), Gaps = 23/203 (11%)
Query: 133 ESRQKKLEMEKL--QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSG-KVIEEA 189
E R++ L+ME +L +E++ + L RLE E ++K L + K K++ + +E+A
Sbjct: 374 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 433
Query: 190 -----QKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEA-QMEKQLSEFDTEREQLRA 243
Q+ + LE+E+ T +L +EL + K R E+EA + + +EF + + +
Sbjct: 434 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 493
Query: 244 KLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTR 303
K T +D+ + M E+LK+ D + S + + ++ +++ R
Sbjct: 494 K--------TLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
Query: 304 SVACQTDL------VTENADHMK 320
++ +TD+ VT+ D +K
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLK 568
Score = 49.3 bits (116), Expect = 3e-05
Identities = 41/173 (23%), Positives = 76/173 (43%), Gaps = 30/173 (17%)
Query: 112 EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV 171
E C +ERM+ + + E K+ ++ +L+A+E +K L+E+ K K +
Sbjct: 440 ECYSLKCNLEKERMTTKQLSQELESLKVRIK--ELEAIESRLEKTEFTLKEDLTKLKTLT 497
Query: 172 LMLVKECKQLSGKVIEEAQKLE--------------DVMAKLEEEKKKTNELEEELSAEK 217
+M V E K +S K+ + KL+ V KL EE K
Sbjct: 498 VMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETK------------- 544
Query: 218 RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK 270
R+ + + +E+++ ER+ L+ KL EE DL ++ ++ ++ L+
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
Score = 46.2 bits (108), Expect = 3e-04
Identities = 65/285 (22%), Positives = 126/285 (44%), Gaps = 48/285 (16%)
Query: 11 DLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVF 70
+L + D G E K E L+K R L + +LE L K +
Sbjct: 374 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL--------SKRIM 425
Query: 71 IQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQL 129
E+ L D F +++ + + EK+ + T LS LE++ K++ E + ++L
Sbjct: 426 ALEK-----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL-EAIESRL 479
Query: 130 AAAESRQKK------------LEMEKLQLQALEQEHKKLAA---RLEEERGKNKQVVLML 174
E K+ ++ K + L++ KL A +L+ E+ K V L
Sbjct: 480 EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 539
Query: 175 VKECKQ-------LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQM 227
++E K+ + K+ ++ +D+ KL+ E++K N+L ++ K R +EA
Sbjct: 540 IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEA-- 597
Query: 228 EKQLSEFDTEREQLRAKLNREEA-HTTDLKEEIDKMRKMIEQLKR 271
E++ L+ KLN++ TT L +E +K++++ ++++R
Sbjct: 598 --------IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 99.8 bits (247), Expect = 2e-20
Identities = 77/254 (30%), Positives = 121/254 (47%), Gaps = 29/254 (11%)
Query: 695 LTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN 754
+ PLL S + GR T L AA G+V ++++LL +G +IN + AL+ AA
Sbjct: 101 IIPLLSSVNVSDRGGR-TALHHAALNGHVEMVNLLL-AKGANINAFDKKDRRALHWAAYM 158
Query: 755 GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPL 814
GH D V LL++ A+V DK G+TPL AAA+ G V+ L++ I+ G T L
Sbjct: 159 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
Query: 815 YLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH-AAVDTGNVDSLKLLMYH-------- 865
++AC NG + L++ G N + +G+TP+H AA T L+LL+ +
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 866 ---RIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
+ P H + + + S +GGE I+ +++G T H+AA
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGE---------------IDCVDKDGNTPLHVAAR 323
Query: 923 KGFKNCLEILCRHG 936
G + + L G
Sbjct: 324 YGHELLINTLRTSG 337
Score = 93.2 bits (230), Expect = 2e-18
Identities = 86/279 (30%), Positives = 128/279 (45%), Gaps = 28/279 (10%)
Query: 698 LLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG 755
L+ +GG + T L AA G+ L++ L G D L+ AA N
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL-RTSGADTAKCGIHSMFPLHLAALNA 358
Query: 756 HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY 815
H+DC R LLS+ +++ DK G T L AAAA G+ EC++LL S A+ + G+TPL+
Sbjct: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418
Query: 816 LACKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAAVDTGNVDSLKLLMYHRIPAHGNS 873
A N + CI+ L+ G N V TD W T +H A ++D K ++ GN+
Sbjct: 419 YAAANCHFHCIETLVTTGAN--VNETDDWGRTALHYAA-ASDMDRNKTIL-------GNA 468
Query: 874 FNEEESESSVFDLDGGEESPEGISKPVVPADLINHAN-----REGWTAAHIAASKGFKNC 928
+ E +L+ E E + + L N AN +EG+ + H AA+ G + C
Sbjct: 469 HDNSE------ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQC 522
Query: 929 LEILCR--HGGLEPERRDKCNRTVHDVATDDCKHLLENL 965
LE+L + G E +H A + LE L
Sbjct: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVL 561
Score = 82.4 bits (202), Expect = 3e-15
Identities = 61/226 (26%), Positives = 107/226 (47%), Gaps = 6/226 (2%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L +A A + + +L+ D+N ++ + L+ AA N C +++ + VN
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSA-DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+D+ G T L AA GH E V LL++ ANIN + L+ A G+ + + LL+
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEE 891
G + K G+TP+HAA G ++ +K L+ + + N + + G++
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLL--NLGVEIDEINVYGNTALHIACYNGQD 227
Query: 892 SPEGISKPVVPADLINHANREGWTAAHI-AASKGFKNCLEILCRHG 936
+ +++ + +N N G+T H AAS CLE+L +G
Sbjct: 228 AV--VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 271
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/224 (26%), Positives = 93/224 (41%), Gaps = 37/224 (16%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-- 769
T L AA +G+ + L+N + L+++ NGHT C+RLLL
Sbjct: 577 TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPE 636
Query: 770 -VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL 828
V+ D G TPL A A GH + V LL+ +AN++ G T L+ G++EC+++
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQM 696
Query: 829 LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG 888
LLE + K + G TP+H A G+ L L+ + F +
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD------------ 744
Query: 889 GEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEIL 932
+G+T H A G +NC+E+L
Sbjct: 745 ----------------------NQGYTPLHWACYNGNENCIEVL 766
Score = 78.6 bits (192), Expect = 5e-14
Identities = 67/232 (28%), Positives = 103/232 (44%), Gaps = 50/232 (21%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCED--GHSALYSAAKNGHTDCVRLLLSAEAQ 769
T L A A G++ +S+LL +E N D G +AL+ GH +CV++LL E
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEA---NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 770 VNAADKNGFTPLCAAAAQGHF----ECVELLISYDANINHAADGGQTPLYLACKNGNKEC 825
+ D G TPL AAA+GH E +++ +S + + + G TPL+ AC NGN+ C
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALS-EEDCCFKDNQGYTPLHWACYNGNENC 762
Query: 826 IKLLLEAGTNRSVKTTDGWTPVHAAV--DTGNVDSLKLLMYHRIPAHGNSFNEEESESSV 883
I++LLE R + +TP+H A+ D GN SL L
Sbjct: 763 IEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLL---------------------- 799
Query: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRH 935
+ + +++ + +G T AA CL++L RH
Sbjct: 800 ---------------GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
Score = 77.4 bits (189), Expect = 1e-13
Identities = 60/207 (28%), Positives = 103/207 (49%), Gaps = 16/207 (7%)
Query: 736 DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL 795
D+N + + L+ AA G + + LL+ + A+VNA D TPL A A E V++
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 796 LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN 855
LI + A++N QTPL++A N +C ++++ ++ +V G T +H A G+
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 856 VDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHA------ 909
V+ + LL+ A+ N+F++++ + + G V A LINH
Sbjct: 128 VEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLD--------VVALLINHGAEVTCK 177
Query: 910 NREGWTAAHIAASKGFKNCLEILCRHG 936
+++G+T H AAS G N ++ L G
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLG 204
Score = 77.4 bits (189), Expect = 1e-13
Identities = 56/156 (35%), Positives = 81/156 (51%), Gaps = 7/156 (4%)
Query: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDG-HSALYSAAKNGHTDCVRLLLSAEAQVNA 772
+ AAA G+ L +LL S S L+ AA NGH + +LL + ++
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG--GQTPLYLACKNGNKECIKLLL 830
D+ G T L AA +GH ECVE LI+ A+I D +TPL+ + NG+ C++LLL
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASI-FVKDNVTKRTPLHASVINGHTLCLRLLL 629
Query: 831 EAGTNR---SVKTTDGWTPVHAAVDTGNVDSLKLLM 863
E N VK G TP+ AV G++D++ LL+
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Score = 75.5 bits (184), Expect = 4e-13
Identities = 77/289 (26%), Positives = 122/289 (42%), Gaps = 74/289 (25%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA+ G + ++ LLN G++I+ G++AL+ A NG V L+ A VN
Sbjct: 183 TPLHAAASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 772 AADKNGFTPLCAAAAQGHFE-CVELLISYDANIN-HAADG-------------------- 809
+ NGFTPL AAA H C+ELL++ A++N + DG
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
Query: 810 ------------GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVD 857
G TPL++A + G++ I L +G + + P+H A + D
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Query: 858 SLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAA 917
+ L+ SS F++D +P+ + G T
Sbjct: 362 CCRKLL-----------------SSGFEID----TPD----------------KFGRTCL 384
Query: 918 HIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCK-HLLENL 965
H AA+ G C+++L + G + ++DKC RT A +C H +E L
Sbjct: 385 HAAAAGGNVECIKLL-QSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Score = 71.6 bits (174), Expect = 6e-12
Identities = 56/189 (29%), Positives = 88/189 (46%), Gaps = 37/189 (19%)
Query: 712 TLLQQAAAQGNVTLLSMLL-------------NEEGLDINYSCEDGH------------- 745
T L AAA+G+ T LS LL N+ ++++C +G+
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772
Query: 746 --------SALYSAAKNGHTDCVRLLLSA--EAQVNAADKNGFTPLCAAAAQGHFECVEL 795
+ L+ A N H +C LLL A + V+ D G TPL AAA H EC++L
Sbjct: 773 RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQL 832
Query: 796 LISYDANINHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTG 854
L+ + A +N + G+T L +A +NG + +L+ A + +VK D TP+H A G
Sbjct: 833 LLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKG 892
Query: 855 NVDSLKLLM 863
+ L++
Sbjct: 893 HEKCALLIL 901
Score = 62.8 bits (151), Expect = 3e-09
Identities = 37/95 (38%), Positives = 54/95 (56%), Gaps = 3/95 (3%)
Query: 740 SCED--GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI 797
SC D G + L +AA H +C++LLL A VNA D +G T L AA G V++L+
Sbjct: 808 SCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV 867
Query: 798 -SYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
S A++ TPL+LAC G+++C L+L+
Sbjct: 868 NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 58.5 bits (140), Expect = 5e-08
Identities = 74/292 (25%), Positives = 122/292 (41%), Gaps = 24/292 (8%)
Query: 762 LLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG 821
+L+ VN D TPL AA G E +ELLI A +N + TPL+ A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 822 NKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESES 881
++E +++L++ + + + + TP+H A V +++ IP + +
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI----IPLLSSVNVSDRGGR 116
Query: 882 SVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
+ E ++ + IN +++ A H AA G + + +L HG E
Sbjct: 117 TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA-EVT 175
Query: 942 RRDKCNRT-VHDVATDDCKHLLENLNALKIPLRISVGEIEPSNYGSDDLE--CENTICAL 998
+DK T +H A++ +N +K L + V E + YG+ L C N A+
Sbjct: 176 CKDKKGYTPLHAAASNG------QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Query: 999 NIRKQTSWDDFSKAVSQALTN-----HFQAISSDGWWSLEDVTCNNTTDSNI 1045
D+ V+Q N HF A S+ G LE + NN D NI
Sbjct: 230 ----VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLE-LLVNNGADVNI 276
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 98.6 bits (244), Expect = 4e-20
Identities = 94/346 (27%), Positives = 147/346 (42%), Gaps = 60/346 (17%)
Query: 709 GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA 768
G T +Q+ A+ T +L + + L++NY DG SAL+ AA G + + LLL A+A
Sbjct: 14 GDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQA 73
Query: 769 QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL 828
V+ D NG PL AA QG E V LL+ A +N A+ GQ PL+LA + G+ E ++
Sbjct: 74 TVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEM 133
Query: 829 LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDG 888
LL+ +N + TP+ A + G + +LL+ S V L+G
Sbjct: 134 LLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL--------------NSHLCVALLEG 179
Query: 889 GEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNR 948
+ P + T H+AA G + + L R G+E R+ K
Sbjct: 180 EAKDP---------------CDPNYTTPLHLAAKNGHREVIRQLLR-AGIEINRQTKTGT 223
Query: 949 TVHDVA----TDDCKHLLENLNALKIPLRISVGEIEPSNYGSDDLECENTI--CALNIRK 1002
+H+ A T+ + LLE G D+ NT AL+I
Sbjct: 224 ALHEAALYGKTEVVRLLLE---------------------GGVDVNIRNTYNQTALDIVN 262
Query: 1003 QTSWDDFSKAVSQAL---TNHFQAISSDGWWSLEDVTCNNTTDSNI 1045
Q + S+ + Q L + + + +W+L D T N ++
Sbjct: 263 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDV 308
Score = 44.3 bits (103), Expect = 0.001
Identities = 88/372 (23%), Positives = 116/372 (31%), Gaps = 59/372 (15%)
Query: 374 PPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPCA 433
P P + + + P + P+ T P L S+ PG P PP ++ +
Sbjct: 715 PAPQPSGGDPSPPQERNLPEGTERPPKLCSSL-------PGQGP-----PPYVFMYPQGS 762
Query: 434 NTSLHPGLNPRIQAARFRFQGN-ANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTV 492
+S PG P A G A PD +S PT D A+ A V
Sbjct: 763 PSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGD---AEGEAEGPV 819
Query: 493 TQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGL 552
L + + P R + T T P T R R PPP PPK+
Sbjct: 820 GSTLGSYAT-LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSS 878
Query: 553 SQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSS--------LPQGNRVINEENLP 604
PSP P L D S GA + S P+ P G EE P
Sbjct: 879 VSGPSPEPPPL----DESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEP 934
Query: 605 -KSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAAT---PGLN-----------QP 649
+P L A G G P T PGL+ +P
Sbjct: 935 GPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRP 994
Query: 650 ACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLM--------S 701
C + + +AF +S PG + L G SP + L
Sbjct: 995 KCREREPLQTALLAF-------GVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQ 1047
Query: 702 GGPAPLAGRPTL 713
G P PLA P +
Sbjct: 1048 GVPTPLAPSPAM 1059
Score = 34.7 bits (78), Expect = 0.79
Identities = 93/417 (22%), Positives = 139/417 (33%), Gaps = 60/417 (14%)
Query: 323 PLTMPVKPSTGSPLVSANAKGSVCTSATMA--------RPGIDRQASYGD----LIGASV 370
PL +P S + A ++GS + A P +R G + +S+
Sbjct: 687 PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSL 746
Query: 371 PAFPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHS 430
P PP + G + P P P S A P A TP P+ + HSL
Sbjct: 747 PGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPA-TPPDPPRPKRR--SHSLSR 803
Query: 431 PCANTSLHPG-LNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLAR 489
P G + + + P ++ SP V+PT A+ R
Sbjct: 804 PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP---SVTPTP-----ARGTPR 855
Query: 490 NTVTQALSRFTSPQAGAPSR-------PGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNP 542
+ +R P P R PP D P G T + ++ +
Sbjct: 856 SQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSE 915
Query: 543 PPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTG---AKVDNKTVASTP---------SS 590
PP PP G + P + S +S G A+ N T+ P +
Sbjct: 916 PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETP 975
Query: 591 LPQGNRVINEENLPKSSSPQLPPK--PSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQ 648
+P G + NL +S + + PK L A V++ P+ TPG +
Sbjct: 976 VPPG----LDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESP 1031
Query: 649 PACS-----DSSLV---IPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTP 697
PA S SSL +PT +A ++ P PG S AS W+ P
Sbjct: 1032 PASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESS---AASRWNGETEP 1085
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 98.2 bits (243), Expect = 6e-20
Identities = 68/246 (27%), Positives = 119/246 (48%), Gaps = 8/246 (3%)
Query: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 773
L +AAA G+V + LL +D+N C GH+A+ +A++NGH D ++LLL V A
Sbjct: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
Query: 774 DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG 833
DK+G + AA +E+L A++N QTPL++A G+ + +K LL+ G
Sbjct: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
Query: 834 TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP---AHGNSFNEEESESSVFDLDGGE 890
+ S++ ++G TP+H A+ D L +L+ + N FN + L G
Sbjct: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAA----LRGNP 609
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTV 950
+ + + +++ +G+TA H+AA E+L G + ++ +T
Sbjct: 610 SAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTA 669
Query: 951 HDVATD 956
+A +
Sbjct: 670 LHLAVE 675
Score = 71.2 bits (173), Expect = 8e-12
Identities = 49/155 (31%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-- 769
T L A ++ +L++LL E G D+ + +G +AL+ AA G+ +R+LLS +
Sbjct: 565 TPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPW 623
Query: 770 -VNAADKNGFTPLCAAAAQGHFECVELLISY-DANINHAADGGQTPLYLACKNGNKECIK 827
V+ +G+T L AA H E ELL+ +AN++ QT L+LA + + + ++
Sbjct: 624 IVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVR 683
Query: 828 LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
LL+ AG ++ DG TP+H A+ + L+ L
Sbjct: 684 LLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 98.2 bits (243), Expect = 6e-20
Identities = 85/281 (30%), Positives = 132/281 (46%), Gaps = 50/281 (17%)
Query: 724 TLLSMLLNEE----GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFT 779
+++S L NE G DIN G + L++AA G+ +C+ LLLS+ A + DK G T
Sbjct: 399 SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458
Query: 780 PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLAC--------------------- 818
PL AAA G ++C L++ A +N A G +PL+ A
Sbjct: 459 PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEED 518
Query: 819 ----KNGNKE---CIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHG 871
++ KE C++ LL+ G + S++ G+T VH A GN +L+LL+
Sbjct: 519 EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSF---- 574
Query: 872 NSFNEEESESSVFDL-----DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFK 926
N + ES V L +G E+ + +++ +V D+ +H +G TA +A +G
Sbjct: 575 NCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH---KGRTALFLATERGST 631
Query: 927 NCLEILCRHG--GLEPERRDKCNRTVHDVATD---DCKHLL 962
C+E+L HG L ER+ K +H A D HLL
Sbjct: 632 ECVEVLTAHGASALIKERKRKWT-PLHAAAASGHTDSLHLL 671
Score = 86.3 bits (212), Expect = 2e-16
Identities = 82/290 (28%), Positives = 129/290 (44%), Gaps = 17/290 (5%)
Query: 679 GASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSMLLNE-EG 734
G + L T G + + L G A + R T L AAA G+ L +L++ E
Sbjct: 618 GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677
Query: 735 LDINYSCED-GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECV 793
DI + G + L A NGH DCV LLL + +AAD G T L A G +C+
Sbjct: 678 ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737
Query: 794 ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTT----DGWTPVHA 849
L+ +DA + G+TP++LA G+ ++ LL+A + G++P+H
Sbjct: 738 AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHW 797
Query: 850 AVDTGNVDSLKLLMYHRIPAH--GNSFNEEESESSVFDLDGGEESPEGISKPVVPADLIN 907
A TG+ D L+LL+ H ++ GN F + ++S + + A ++N
Sbjct: 798 ASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA-----VINNQDSTTEMLLGALGAKIVN 852
Query: 908 HANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDD 957
+ +G T H AA + L +L +H E D RT A ++
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQA-EVNATDHTGRTALMTAAEN 901
Score = 84.7 bits (208), Expect = 7e-16
Identities = 76/250 (30%), Positives = 123/250 (49%), Gaps = 14/250 (5%)
Query: 693 PSLTPLLMSGGPAPLAGRPTL----LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSAL 748
P L LLMSG A + + TL L +AAA N +L +LL D+N + + L
Sbjct: 55 PILQLLLMSG--ANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA-DVNARDKLWQTPL 111
Query: 749 YSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD 808
+ AA N T C L + +N AD++G + L A GH E V LL++ A++N
Sbjct: 112 HVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171
Query: 809 GGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
+ PL+ A G+ E +KLL+ G + K G+ +H A +G ++ +K L+ R+
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL--RMG 229
Query: 869 AHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADL-INHANREGWTAAHIAA-SKGFK 926
A + N + + G+++ ++ +V A +N N +G+T H+AA S
Sbjct: 230 AEIDEPNAFGNTALHIACYLGQDA---VAIELVNAGANVNQPNDKGFTPLHVAAVSTNGA 286
Query: 927 NCLEILCRHG 936
CLE+L +G
Sbjct: 287 LCLELLVNNG 296
Score = 77.4 bits (189), Expect = 1e-13
Identities = 70/256 (27%), Positives = 115/256 (44%), Gaps = 25/256 (9%)
Query: 713 LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA 772
LL AAA G + ++ LL G +I+ G++AL+ A G L++A A VN
Sbjct: 209 LLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 773 ADKNGFTPLCAAAAQGHFE-CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
+ GFTPL AA + C+ELL++ A++N+ + G++PL++A +G ++L++
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 832 AGTNRSVKTTDGWTPVHAAVDTGN-----------VDSLKLLMYHRIPAH-------GNS 873
G+ G TP+H A G+ D+ + ++ P H +
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Query: 874 FNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILC 933
+ S ++ + + +S IN + G T H AAS G CL +L
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFD----INTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 934 RHGGLEPERRDKCNRT 949
G + RRDK RT
Sbjct: 444 -SSGADLRRRDKFGRT 458
Score = 73.6 bits (179), Expect = 2e-12
Identities = 55/170 (32%), Positives = 79/170 (46%), Gaps = 18/170 (10%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AA N L LL G D+NY ++G S L+ AA +G ++L+ ++++
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333
Query: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
ADK G TPL AA GH + L++ A+ PL+LA G +C + LL
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
Query: 832 AGTNRS----------------VKTTD--GWTPVHAAVDTGNVDSLKLLM 863
+G S + T D G T +HAA GNV+ L LL+
Sbjct: 394 SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Score = 73.6 bits (179), Expect = 2e-12
Identities = 73/254 (28%), Positives = 105/254 (41%), Gaps = 58/254 (22%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS------ 765
T L AA G+ L+S L+ G D L+ A G +DC R LLS
Sbjct: 341 TPLHVAARYGHELLISTLMTN-GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS 399
Query: 766 ------------AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP 813
A +N D G T L AAA+ G+ EC+ LL+S A++ G+TP
Sbjct: 400 IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
Query: 814 LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH--AAVDTGNVDSLKLLMYHRIPAHG 871
L+ A NG+ +C L+ AG + G +P+H AA DT Y R H
Sbjct: 460 LHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT----------YRRAEPHT 509
Query: 872 NSFNEEESESSV-------------FDLDGGEESPEGISKPVVPADLINHANREGWTAAH 918
S ++ E + + F LD G + + +R+G+TA H
Sbjct: 510 PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP--------------SLRDRQGYTAVH 555
Query: 919 IAASKGFKNCLEIL 932
AA+ G + LE+L
Sbjct: 556 YAAAYGNRQNLELL 569
Score = 70.9 bits (172), Expect = 1e-11
Identities = 65/250 (26%), Positives = 117/250 (46%), Gaps = 8/250 (3%)
Query: 703 GPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRL 762
G + +P L+Q ++ + S+L +E +IN ++ + L++AA G ++L
Sbjct: 2 GILSITDQPPLVQAIFSRDVEEVRSLLSQKE--NINVLDQERRTPLHAAAYVGDVPILQL 59
Query: 763 LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGN 822
LL + A VNA D TPL AAA + + + LL+++ A++N QTPL++A N
Sbjct: 60 LLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRA 119
Query: 823 KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE-EESES 881
+C + L ++ +V G + +H AV +G+++++ LL+ G S N ++ E
Sbjct: 120 TKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL-----NKGASLNVCDKKER 174
Query: 882 SVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
E + V + +R+G+ H AA+ G ++ L R G E
Sbjct: 175 QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDE 234
Query: 942 RRDKCNRTVH 951
N +H
Sbjct: 235 PNAFGNTALH 244
Score = 70.1 bits (170), Expect = 2e-11
Identities = 66/235 (28%), Positives = 98/235 (41%), Gaps = 24/235 (10%)
Query: 730 LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFT----PLCAAA 785
L + G D + G++A++ AA G+ + LLL E N + T PL AA
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL--EMSFNCLEDVESTIPVSPLHLAA 593
Query: 786 AQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD-GW 844
GH E ++ L N++ G+T L+LA + G+ EC+++L G + +K W
Sbjct: 594 YNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKW 653
Query: 845 TPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVV--- 901
TP+HAA +G+ DSL LL+ E + V D G I V
Sbjct: 654 TPLHAAAASGHTDSLHLLI---------DSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
Query: 902 -----PADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVH 951
+ A+ G TA H A G ++CL L H R K +H
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIH 759
Score = 67.0 bits (162), Expect = 1e-10
Identities = 50/157 (31%), Positives = 78/157 (49%), Gaps = 6/157 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQV 770
T L AA NV+ L MLL + ++N + G +AL +AA+NG T V LL +A +
Sbjct: 860 TPLHAAAFADNVSGLRMLLQHQA-EVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADL 918
Query: 771 NAADKNGFTPLCAAAAQGHFECVELLISYDAN---INHAADGGQTPLYLACKNGNKECIK 827
D+N T L A ++GH +C ++++ + IN Q PL++A +NG ++
Sbjct: 919 TVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQ 978
Query: 828 LLLEAGTNRSVKTTDGWTPVHAAVDTGNV-DSLKLLM 863
LL G +G TP A +V D L L++
Sbjct: 979 ALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
Score = 65.1 bits (157), Expect = 5e-10
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 14/220 (6%)
Query: 724 TLLSMLLNEEGLD--INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPL 781
TLL L+ + LD ++YS G+S ++ A+ GH DC+ LLL + + + N FTPL
Sbjct: 772 TLLQAALSTDPLDAGVDYS---GYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPL 827
Query: 782 CAAAAQGHFECVELLI-SYDANINHAADG-GQTPLYLACKNGNKECIKLLLEAGTNRSVK 839
A E+L+ + A I ++ D G+TPL+ A N +++LL+ +
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887
Query: 840 TTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDL---DGGEESPEGI 896
G T + A + G +++ L+Y + +E++++ L G E+ I
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYR---GKADLTVLDENKNTALHLACSKGHEKCALMI 944
Query: 897 SKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
LIN N HIAA G + ++ L HG
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
Score = 39.7 bits (91), Expect = 0.025
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 683 SLLVTASGWSPSLTPLLMSGGPAPLA----GRPTLLQQAAAQGNVTLLSMLLNEE---GL 735
+L+ A + L+ G A L + T L A ++G+ M+L E GL
Sbjct: 894 ALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL 953
Query: 736 DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHF-ECVE 794
IN + L+ AA+NG V+ LLS A V A D+ G TP A A +C+
Sbjct: 954 -INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLA 1012
Query: 795 LLIS 798
L++S
Sbjct: 1013 LILS 1016
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 97.8 bits (242), Expect = 8e-20
Identities = 77/288 (26%), Positives = 130/288 (45%), Gaps = 40/288 (13%)
Query: 20 AGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARR-KEVFIQERYGRF 78
+G KK + LSK +L LLS+MEGEL+AR+ VI L+ + K ++ YG
Sbjct: 62 SGECERKTKKSLE---LSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSA 118
Query: 79 NLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKK 138
L RD + V P+S L+ + K+ RM QL AE ++
Sbjct: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRR 178
Query: 139 -------------------------LEMEKLQLQALEQEHKKLAARLEEERGKN------ 167
LE E+ +L+ L ++ K AR E+E K
Sbjct: 179 TVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRD 238
Query: 168 -----KQVVLMLVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTE 222
K LMLV E + ++ ++QK++D+ KL EE++K + + ++++ +
Sbjct: 239 ELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLK 298
Query: 223 MEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK 270
+E E + S F E E++ AKL +E+H L+ ++ + + IE+L+
Sbjct: 299 LEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 346
Score = 69.7 bits (169), Expect = 2e-11
Identities = 70/296 (23%), Positives = 136/296 (45%), Gaps = 30/296 (10%)
Query: 11 DLSRAPEDAAGAAAEAAKKEFDVDTLSKS--ELRMLLSVMEGELEARDLVIEALRARRKE 68
+L +A E+ + AK E +L LR + MEG+ E R RK+
Sbjct: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKK 410
Query: 69 VFIQERYGRF------NLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQ 122
+ +E + + L L++ EA + K + CT L + K +
Sbjct: 411 LQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE---CTQ----LHLNLEKEKNLT 463
Query: 123 ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS 182
+ + +L +SR K+LE + +L+ E L+++ K K +MLV E K +
Sbjct: 464 KDLLNELEVVKSRVKELECSESRLEKAELS-------LKDDLTKLKSFTVMLVDERKNMM 516
Query: 183 GKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLR 242
K+ +E +K++ + + E+ K ++ E+L E ++ +++++ME+++ ER++L
Sbjct: 517 EKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELI 576
Query: 243 AKLNREEAHTTDLKEEIDKMRKMIE-------QLKRGSDSKPS-LSLPRKTKDRRL 290
KL EE +++L +D ++K ++ ++ RG K S L+ P K + L
Sbjct: 577 GKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKEL 632
Score = 52.4 bits (124), Expect = 4e-06
Identities = 99/479 (20%), Positives = 188/479 (39%), Gaps = 73/479 (15%)
Query: 112 EAVMAHCKKMQERMSAQLAAAESRQKKLE-MEKLQLQALEQEHKKLAARLEEERGKNKQV 170
+ ++ K +E+ S + + +K+L+ +E+++ + +K + E K K++
Sbjct: 573 DELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKEL 632
Query: 171 VLMLVKECKQLSG-KVIE-EAQKLEDVMAKLEE----EKKKTNELEEELSAEKRRSTEME 224
L + + K+L +V+E + K ED +LE+ E+ K N L ++L K + + +
Sbjct: 633 TLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNK 692
Query: 225 AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK 284
A +EK E ++ +LR + EEA + DLK E+ +++ I +L D L +
Sbjct: 693 A-IEK--GEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYS 749
Query: 285 TKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGS------PLVS 338
+R + E +++ + +T+ + K+ + ++PS P+ S
Sbjct: 750 VLQQRFME-----EENKNKNMGQEVLNLTKELELSKR--YSRALRPSVNGRRMVDVPVTS 802
Query: 339 ANAKGSVCT--SATMARPGIDRQASYGD---------LIGASVPAFP-------PPSANK 380
+ + +A P + + S+ + +G P PP+AN+
Sbjct: 803 TGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANE 862
Query: 381 I------------EENGPSTGSTPDP-TSSTPPLPSNAA-PPTAQTP---GIAPQNSQAP 423
+ ENGPS P T+S+P P P P + P + +
Sbjct: 863 LTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENST 922
Query: 424 PMHSLHSPC-----ANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTS 478
+ SP ++T++ P L + N Q T P R +SP +
Sbjct: 923 ATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSPVT 982
Query: 479 RDNLVAKQLARNTVTQALSRFTSP-------QAGAPSRPGVPPTGDVGTHPPVGRTSLK 530
++ + R TSP + AP+ V P P+GRT LK
Sbjct: 983 ITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQ---EMPMGRTILK 1038
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 97.4 bits (241), Expect = 1e-19
Identities = 66/226 (29%), Positives = 110/226 (48%), Gaps = 7/226 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA-QV 770
T + A G ++ +LL G+D++ +D L+ AA GH V+LL V
Sbjct: 539 TPMHVACQHGQENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSV 597
Query: 771 NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL 830
NA +G TPL AA +GH+ +LI +++N + QTPL++A + G+ +LLL
Sbjct: 598 NAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657
Query: 831 EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGE 890
G + T+DG+T +H A G++ ++KLL+ + + L
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG----PLNQTALHLAAAH 713
Query: 891 ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
E + + +V AD+I+ + +G +A H+AA +E L RHG
Sbjct: 714 GHSEVVEE-LVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 77.0 bits (188), Expect = 1e-13
Identities = 41/125 (32%), Positives = 70/125 (56%)
Query: 738 NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI 797
N S G + L+ A + V LLL+ + VNA D++ +T L AA G LL+
Sbjct: 465 NLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL 524
Query: 798 SYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVD 857
+A++N G+TP+++AC++G + +++LL G + S++ D W P+H A G++
Sbjct: 525 EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLP 584
Query: 858 SLKLL 862
+KLL
Sbjct: 585 IVKLL 589
Score = 66.6 bits (161), Expect = 2e-10
Identities = 54/236 (22%), Positives = 100/236 (42%), Gaps = 39/236 (16%)
Query: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 773
L A G+ + L +L + D++ + + G S L+ A + G +C + LL A N +
Sbjct: 410 LVDAIVSGDTSKLMKILQPQ--DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLS 467
Query: 774 DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG 833
++ G TPL A + VELL++ ++N + T L+ A +NG++ +LLLE
Sbjct: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 834 TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESP 893
+ + +G TP+H A G + +++L+ G + S
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRR----------------------GVDVSL 565
Query: 894 EGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRT 949
+G ++ W H AA +G +++L + G+ + RT
Sbjct: 566 QG---------------KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Score = 62.8 bits (151), Expect = 3e-09
Identities = 48/159 (30%), Positives = 78/159 (49%), Gaps = 3/159 (1%)
Query: 707 LAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA 766
L GR T L AA +G+ + +L++ D+N + L+ AA+ GHT RLLL
Sbjct: 602 LDGR-TPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAETGHTSTARLLLHR 659
Query: 767 EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI 826
A A +G+T L AA GH V+LL+ A++ QT L+LA +G+ E +
Sbjct: 660 GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVV 719
Query: 827 KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH 865
+ L+ A + G + +H A + +++ L+ H
Sbjct: 720 EELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Score = 32.0 bits (71), Expect = 5.1
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
T L AAA G+ ++ L++ + +D+ E G SAL+ AA+ H V LL A +N
Sbjct: 705 TALHLAAAHGHSEVVEELVSADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,207,506
Number of Sequences: 37866
Number of extensions: 3549862
Number of successful extensions: 36757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 804
Number of HSP's successfully gapped in prelim test: 1757
Number of HSP's that attempted gapping in prelim test: 16808
Number of HSP's gapped (non-prelim): 12892
length of query: 1663
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1547
effective length of database: 13,855,062
effective search space: 21433780914
effective search space used: 21433780914
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.